title: Negative Effects of Total Gastrectomy on Bone Tissue Metabolism and Volumetric Bone Mineral Density (vBMD) of Lumbar Spine in 1-Year Study in Men.
abstract: Gastrectomy induces severe osteoporosis in humans but its quantitative scale within trabecular and cortical compartments was not estimated. The aim of the study was to determine changes of volumetric bone mineral density (vBMD) in lumbar vertebrae (L1-L4) and biochemical bone metabolism markers in serum of patients 1 year after total gastrectomy. The control group consisted of patients (N = 8) subjected to abdominal surgery due to cardiospasmus. Total gastrectomy was performed in the experimental group (N = 6). Volumetric bone mineral density of trabecular and cortical bone of lumbar spine was measured before (baseline) and 1 year after the gastric surgery using the quantitative computed tomography method. Serum concentrations of insulin, insulin-like growth factor-1, tyroxine, interleukin-6, C-terminal telopeptides of type II collagen and bone formation, and resorption markers were determined at baseline and 1 year later, using ELISA, EIA, and IEMA methods. Total gastrectomy induced significant decrease of vBMD values, up to 16.8% and 10.0%, within the trabecular and cortical bone compartments of lumbar spine (P < 0.05). These negative changes of vBMD were associated with significantly increased serum concentration of bone resorption markers such as deoxypyridinoline, pyridinoline, and C-terminal telopeptides of type I collagen, by 13.5%, 32.2%, and 121.5%, respectively (P < 0.05). Neither vBMD nor biochemical bone turnover markers and hormone concentrations were influenced in the control patients. Dramatic bone loss during the first year in gastrectomized patients has proven dynamic osteoporosis progress indicating an importance of treatment interventions in these patients with emphasis on inhibition of intensive bone resorption processes.
authors.affiliation: From the II Department of Radiology, Medical University of Lublin (WK, MRT); Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin (MRT); II Department of General and Gastroenterological Surgery and Surgical Oncology of the Alimentary Tract (PB, GW, AD); Department of Prosthetic Dentistry, Medical University in Lublin, Lublin (AS); Institute of Health, Faculty of Natural Science, Siedlce University of Natural Sciences and Humanities, Siedlce (AC); and Human Anatomy Department, Medical University in Lublin, Lublin, Poland (RM).
authors.forename: Witold
authors.initials: W
authors.lastname: Krupski
authors.forename: Marcin R
authors.initials: MR
authors.lastname: Tatara
authors.forename: Pawel
authors.initials: P
authors.lastname: Bury
authors.forename: Anna
authors.initials: A
authors.lastname: Szabelska
authors.forename: Anna
authors.initials: A
authors.lastname: Charuta
authors.forename: Ryszard
authors.initials: R
authors.lastname: Maciejewski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Wallner
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dabrowski
mesh_terms: D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D016022:Case-Control Studies; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000009:adverse effects*; D006728:Hormones / Q000097:blood; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000209:etiology* / Q000473:pathology; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology* / Q000473:pathology
chemical_list: D015415:Biomarkers; D006728:Hormones