title: Factors associated with treatment for latent tuberculosis in persons living with HIV/AIDS.
abstract: The aim was to identify factors associated with non-initiation of prophylactic treatment of latent tuberculosis infection (LTBi) in persons living with HIV/AIDS (PLWA), based on a prospective cohort study of PLWA ≥ 18 years of age in two referral services for HIV/AIDS. Of the 232 patients eligible for treatment of LTBi, 69.8% initiated treatment. Following multivariate logistic regression analysis, only treatment in one of the two referral services was associated with non-initiation of treatment for LTBi (p < 0.001). TB incidence in the cohort was 0.6/100 person-years. TB incidence in patients that initiated treatment of LTBi was 0.4/100 person-years, compared to 1.2/100 person-years in those that did not initiate treatment, but the difference was not statistically significant. The study's most interesting finding was that the main factor associated with the likelihood of treatment for LTBi was the health service where the patient was treated.
authors.affiliation: Universidade Federal de Pernambuco, Recife, Brasil.
authors.forename: Daniela Silva de
authors.initials: DS
authors.lastname: Aquino
authors.affiliation: Universidade Federal de Pernambuco, Recife, Brasil.
authors.forename: Líbia Cristina Rocha Vilela
authors.initials: LC
authors.lastname: Moura
authors.affiliation: Hospital Correia Picanço, Recife, Brasil.
authors.forename: Magda
authors.initials: M
authors.lastname: Maruza
authors.affiliation: Hospital Correia Picanço, Recife, Brasil.
authors.forename: Adriana Paula da
authors.initials: AP
authors.lastname: Silva
authors.affiliation: Universidade Federal de Pernambuco, Recife, Brasil.
authors.forename: Ricardo Arraes de Alencar
authors.initials: RA
authors.lastname: Ximenes
authors.affiliation: Universidade Federal de Pernambuco, Recife, Brasil.
authors.forename: Heloísa Ramos
authors.initials: HR
authors.lastname: Lacerda
authors.affiliation: Universidade Federal de Pernambuco, Recife, Brasil.
authors.forename: Demócrito de Barros
authors.initials: Dde B
authors.lastname: Miranda Filho
authors.affiliation: Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Brasil.
authors.forename: Maria de Fátima Pessoa Militão de
authors.initials: Mde F
authors.lastname: Albuquerque
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D055985:Latent Tuberculosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid