title: Is anti-Müllerian hormone associated with IVF outcomes in young patients with diminished ovarian reserve?
abstract: OBJECTIVE
  To investigate whether anti-Müllerian hormone (AMH) is associated with IVF cycle outcomes in young patients with diminished ovarian reserve.
  
  
  METHODS
  Retrospective study of patients <35 years of age undergoing fresh IVF who had at least two 8-cell, day-3 embryos transferred with grades 1, 1.5 or 2. Patients were subgrouped, a priori, based on serum AMH levels: <1 or >1 ng/ml and <0.5 or >0.5 ng/ml.
  
  
  RESULTS
  In total, 1005 patients were included. Patients in the >1 ng/ml group required lesser gonadotropins compared with the <1 ng/ml and the <0.5 ng/ml group. More oocytes were retrieved from the same group compared with the latter two (p < 0.001). Despite these differences, the overall rates of clinical pregnancy, spontaneous abortion and live birth were comparable between the two groups.
  
  
  CONCLUSIONS
  In patients with diminished ovarian reserve who have good quality embryos, AMH is not associated with clinical pregnancy, spontaneous miscarriage or live birth rates.
authors.affiliation: The Ronald O Perelman & Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, 1300 York Ave., New York, NY 10065, USA.
authors.forename: Nigel
authors.initials: N
authors.lastname: Pereira
authors.affiliation: Department of Obstetrics & Gynecology, Weill Cornell Medical College, 1300 York Ave., New York, NY 10065, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Setton
authors.affiliation: Department of Obstetrics & Gynecology, Weill Cornell Medical College, 1300 York Ave., New York, NY 10065, USA.
authors.forename: Allison C
authors.initials: AC
authors.lastname: Petrini
authors.affiliation: The Ronald O Perelman & Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, 1300 York Ave., New York, NY 10065, USA.
authors.forename: Jovana P
authors.initials: JP
authors.lastname: Lekovich
authors.affiliation: The Ronald O Perelman & Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, 1300 York Ave., New York, NY 10065, USA.
authors.forename: Rony T
authors.initials: RT
authors.lastname: Elias
authors.affiliation: The Ronald O Perelman & Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, 1300 York Ave., New York, NY 10065, USA.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Spandorfer
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood* / Q000627:therapeutic use*; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone
keywords: IVF; anti-Müllerian hormone; diminished ovarian reserve; outcomes; prediction