title: Florid reactive lymphoid hyperplasia (lymphoma-like lesion) of cervix: A diagnostically challenging case and a brief review of literature.
abstract: Large lymphoid proliferations are usually regarded as synonymous with lymphomas. However, lymphoma-like lesions. (LLLs) of the cervix are amongst the exception. We report a 46-year-old woman who complained of irregular menses and was found to have superficial erosion in cervix, which on biopsy showed clusters of large atypical appearing lymphoid cells admixed with smaller reactive lymphoid cells. On immunohistochemistry, these large cells were strongly positive for CD20 and CD30 and the background cells were reactive to CD3. Based on the superficial nature of infiltrate and absence of a mass-forming lesion, a diagnosis of LLL of cervix was made. Despite a benign diagnosis, a hysterectomy was done on patient's insistence and only a focus of lymphoid cells similar to biopsy was seen on the operated specimen. Patient is free of disease on follow-up.
authors.forename: Trupti
authors.initials: T
authors.lastname: Pai
authors.affiliation: Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Menon
authors.forename: Kedar
authors.initials: K
authors.lastname: Deodhar
authors.forename: Tanuja
authors.initials: T
authors.lastname: Shet
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002584:Cervix Uteri / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D011379:Prognosis; D019310:Pseudolymphoma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor