title: LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease.
abstract: To fulfill their multiple roles in organ development and adult tissue homeostasis, hedgehog (HH) morphogens act through their receptor Patched (PTCH) on target cells. However, HH actions also require HH binding proteins, auxiliary cell surface receptors that agonize or antagonize morphogen signaling in a context-dependent manner. Here, we discuss recent findings on the LDL receptor-related protein 2 (LRP2), an exemplary HH binding protein that modulates sonic hedgehog activities in stem and progenitor cell niches in embryonic and adult tissues. LRP2 functions are crucial for developmental processes in a number of tissues, including the brain, the eye, and the heart, and defects in this receptor pathway are the cause of devastating congenital diseases in humans. Developmental Dynamics 245:569-579, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, 13125, Berlin, Germany.
authors.forename: Annabel
authors.initials: A
authors.lastname: Christ
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, 13125, Berlin, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Herzog
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, 13125, Berlin, Germany.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Willnow
mesh_terms: D000818:Animals; D000013:Congenital Abnormalities / Q000196:embryology / Q000209:etiology; D047108:Embryonic Development; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D026561:Low Density Lipoprotein Receptor-Related Protein-2 / Q000172:deficiency / Q000502:physiology*; D009024:Morphogenesis; D015398:Signal Transduction / Q000502:physiology
chemical_list: D053823:Hedgehog Proteins; D026561:Low Density Lipoprotein Receptor-Related Protein-2
keywords: Donnai-Barrow syndrome; LDL receptor related proteins; LRP2; endocytosis; forebrain development; hedgehog binding proteins; holoprosencephaly; morphogen signaling; sonic hedgehog