title: Effects of essential oil of Satureja khuzestanica on the oxidative stress in experimental hyperthyroid male rat.
abstract: This work analyzes the effects of Satureja khuzestanica essential oil (SKEO) on the thyroid and antioxidant system, assessed by measuring levels of tri-iodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), malondialdehyde (MDA), reduced glutathione (GSH), and glutathione peroxidase (GPx) activity. Forty adult male Sprague Dawley rats (225 ± 25 g) were divided into five equal groups: one control and four hyperthyroid groups that received placebo, 200 mg kg(-1) body weight of vitamin (Vit.) E, 225 mg kg(-1) body weight of SKEO, 200 and 225 mg kg(-1) body weight of Vit. E and SKEO together, respectively. Hyperthyroidism was induced by administering of L-thyroxin in drinking water. After 30 days of L-thyroxin consumption, serum T3 and T4 levels, TSH, and oxidative stress indices were determined. Significant increase in serum T3, T4 and MDA concentrations with a simultaneous significant decrease in TSH, GSH level and GPx activity were observed in hyperthyroid group (p <0.05). In the treatment groups, SKEO and/or Vit. E can compensate serum MDA elevation and GPx activity reduction. Only, SKEO + Vit. E could compensate the decline of GSH levels in response to hyperthyroidism. Supplementation of SKEO, plus Vit. E as antioxidants is useful in attenuating lipid peroxidation and may potentially benefit hyperthyroid patients.
authors.affiliation: Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;; Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran;
authors.forename: Raheleh
authors.initials: R
authors.lastname: Assaei
authors.affiliation: Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; ; Recombinant Protein Laboratory, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Mostafavi-Pour
authors.affiliation: Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Naser
authors.initials: N
authors.lastname: Pajouhi
authors.affiliation: Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Gholam Hossein
authors.initials: GH
authors.lastname: Ranjbar Omrani
authors.affiliation: Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Masood
authors.initials: M
authors.lastname: Sepehrimanesh
authors.affiliation: Reproductive Biology Department, School of Advanced Medical Sciences and Technologies, Shiraz, Iran; ; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Zal
keywords: Essential oil; Experimental hyperthyroidism; Glutathione; Malondialdehyde; Satureja