title: Molecular processes in the streptokinase thrombolytic therapy.
abstract: The aim of this research is to evaluate the current streptokinase thrombolytic treatment and to identify or improve new techniques that will base new approaches with a higher efficiency in this area of expertise. In order to be as realistic as possible a new method was set up using magnetic vectorized nanoparticles streptokinase and human blood thrombus. The experimental data confirm the maximum 83% thrombus lyses whenever increase streptokinase concentration. It is very probable to happen because of the presence of high concentration of antiplasmin in the blood that neutralizes around half of the thrombolytic potential of the sanguine plasminogen. The experiment shows also that only free serum plasminogen are available for streptokinase action in order to generate plasmin.
authors.affiliation: a S.C. Ecodet Activ S.R.L , Fizicienilor No.22, BL.21A, Sc.1, Ap.22, Bucharest, 3 , Romania .|b National Environmental Protection Agency , Splaiul Independentei No. 294, Bucharest, 6 , Romania .
authors.forename: Cristian
authors.initials: C
authors.lastname: Capitanescu
authors.affiliation: c Carol Davila University of Medicine and Pharmacy , Dionisie Lupu No. 37, Bucharest, 1 , Romania .
authors.forename: Anca Monica
authors.initials: AM
authors.lastname: Macovei Oprescu
authors.affiliation: d Clinical Hospital Grigore Alexandrescu , Iancu De Hunedoara No. 30-32, Bucharest, 1 , Romania .
authors.forename: Dan
authors.initials: D
authors.lastname: Ionita
authors.affiliation: e University "Titu Maiorescu" , Gheorghe Petrascu No. 67A, Bucharest, 3 , Romania , and.
authors.forename: Gabi Valeriu
authors.initials: GV
authors.lastname: Dinca
authors.affiliation: c Carol Davila University of Medicine and Pharmacy , Dionisie Lupu No. 37, Bucharest, 1 , Romania .
authors.forename: Claudiu
authors.initials: C
authors.lastname: Turculet
authors.affiliation: e University "Titu Maiorescu" , Gheorghe Petrascu No. 67A, Bucharest, 3 , Romania , and.|f Clinical Hospital Colentina , Stefan Cel Mare No. 19-21, Bucharest, 2 , Romania.
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Manole
authors.affiliation: c Carol Davila University of Medicine and Pharmacy , Dionisie Lupu No. 37, Bucharest, 1 , Romania .
authors.forename: Radu Alexandru
authors.initials: RA
authors.lastname: Macovei
mesh_terms: D006801:Humans; D013300:Streptokinase / Q000627:therapeutic use*; D015912:Thrombolytic Therapy
chemical_list: D013300:Streptokinase
keywords: Antiplasmin; magnetic nanoparticle; streptokinase; thrombus