title: Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck.
abstract: Adenoid cystic carcinoma (ACC) of the head and neck is a rare but highly malignant tumor. Cancer-testis antigens (CTAs) represent an immunogenic family of cancer-specific proteins and thus represent an attractive target for immunotherapy.
  
  
  
  Eighty-four cases of ACC were identified, the CTAs pan-Melanoma antigen (pan-MAGE; M3H67) and New York esophageal squamous cell carcinoma (NY-ESO-1; E978) were detected immunohistochemically (IHC) and correlated with clinical data.
  
  
  
  Expression of NY-ESO-1 was found in 48 of 84 patients (57.1%) and of pan-MAGE in 28 of 84 patients (31.2%). Median overall survival (OS) in NY-ESO-1 positive versus negative patients was 130.8 and 282.0 months (p = .223), respectively. OS in pan-MAGE positive versus negative patients was 105.3 and 190.5 months, respectively (p = .096). Patients expressing both NY-ESO-1 and pan-MAGE simultaneously had significantly reduced OS with a median of 90.5 months compared with 282.0 months in negative patients (p = .047).
  
  
  
  A significant fraction of patients with ACC show expression of the CTAs NY-ESO-1 and/or pan-MAGE with promising immunotherapeutic implications. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1008-1016, 2016.
authors.affiliation: Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Veit
authors.affiliation: Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Heine
authors.affiliation: Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Thierauf
authors.affiliation: Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Jochen
authors.initials: J
authors.lastname: Lennerz
authors.affiliation: Department of Ear, Nose and Throat Surgery, Kensington Hospital, Whangarei, New Zealand.
authors.forename: Subasch
authors.initials: S
authors.lastname: Shetty
authors.affiliation: Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Schuler
authors.affiliation: Department of Pathology, University of Pittsburgh, Hillman Cancer Center, Pittsburgh, Pennsylvania.
authors.forename: Theresa
authors.initials: T
authors.lastname: Whiteside
authors.affiliation: Department of Otorhinolaryngology, University of Cologne, Cologne, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Beutner
authors.affiliation: Department of Otorhinolaryngology, University of Cologne, Cologne, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Meyer
authors.affiliation: Institute of Pathology, University of Cologne, Cologne, Germany.
authors.forename: Inga
authors.initials: I
authors.lastname: Grünewald
authors.affiliation: Ludwig Institute for Cancer Research and Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Gerd
authors.initials: G
authors.lastname: Ritter
authors.affiliation: Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, New York, New York.
authors.forename: Sacha
authors.initials: S
authors.lastname: Gnjatic
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Sikora
authors.affiliation: Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Hoffmann
authors.affiliation: Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
authors.forename: Simon
authors.initials: S
authors.lastname: Laban
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001707:Biopsy, Needle; D003528:Carcinoma, Adenoid Cystic / Q000097:blood / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D016009:Chi-Square Distribution; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D058950:Melanoma-Specific Antigens / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C104948:CTAG1B protein, human; C072011:MAGEA1 protein, human; D058950:Melanoma-Specific Antigens; D008565:Membrane Proteins
keywords: Melanoma antigen; New York esophageal squamous cell carcinoma (NY-ESO-1); adenoid cystic carcinoma; cancer-testis antigens; head and neck cancer