title: Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons.
abstract: Dopamine (DA) neurons in the ventral tegmental area (VTA) help mediate stress susceptibility and resilience. However, upstream mechanisms controlling these neurons remain unknown. Noradrenergic (NE) neurons in the locus coeruleus, implicated in the pathophysiology of depression, have direct connections within the VTA. Here we demonstrate that NE neurons regulate vulnerability to social defeat through inhibitory control of VTA DA neurons.
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
authors.forename: Elsa
authors.initials: E
authors.lastname: Isingrini
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
authors.forename: Léa
authors.initials: L
authors.lastname: Perret
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
authors.forename: Quentin
authors.initials: Q
authors.lastname: Rainer
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Amilhon
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
authors.forename: Elisa
authors.initials: E
authors.lastname: Guma
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Tanti
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.|Sorbonne Universités, Neuroscience Paris Seine, CNRS UMR 8246, INSERM U 1130, Université Pierre et Marie Curie, Paris, France.
authors.forename: Garance
authors.initials: G
authors.lastname: Martin
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Robinson
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
authors.forename: Luc
authors.initials: L
authors.lastname: Moquin
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.|Sorbonne Universités, Neuroscience Paris Seine, CNRS UMR 8246, INSERM U 1130, Université Pierre et Marie Curie, Paris, France.
authors.forename: Fabio
authors.initials: F
authors.lastname: Marti
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
authors.forename: Naguib
authors.initials: N
authors.lastname: Mechawar
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Williams
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
authors.forename: Alain
authors.initials: A
authors.lastname: Gratton
authors.affiliation: Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.|Sorbonne Universités, Neuroscience Paris Seine, CNRS UMR 8246, INSERM U 1130, Université Pierre et Marie Curie, Paris, France.
authors.forename: Bruno
authors.identifier: http://orcid.org/0000-0001-5876-9822
authors.initials: B
authors.lastname: Giros
mesh_terms: D059331:Adrenergic Neurons / Q000502:physiology*; D000818:Animals; D002908:Chronic Disease; D059290:Dopaminergic Neurons / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009433:Neural Inhibition / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D055500:Resilience, Psychological; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism* / Q000523:psychology; D017557:Ventral Tegmental Area / Q000378:metabolism; D050493:Vesicular Monoamine Transport Proteins / Q000172:deficiency / Q000235:genetics
chemical_list: C493453:Slc18a2 protein, mouse; D050493:Vesicular Monoamine Transport Proteins; D009638:Norepinephrine