title: Does bendamustine impact the mobilization of peripheral blood stem cells? A multicenter retrospective study of 23 cases.
abstract: Bendamustine is used in the treatment of different relapsing or refractory subtypes of lymphoma. Its impact on the yield of peripheral blood stem cells is not well known. Twenty three patients who received bendamustine followed immediately or after another chemotherapy by stem cell mobilization (SCM) were included. The patients were divided into two groups: group 1 (n=17), in whom SCM was performed immediately after bendamustine chemotherapy, and group 2 (n=6), in whom SCM was performed after another cycle of chemotherapy. The success rate of mobilization after Bendamustine+/-plerixafor was 36% (eight cytapheresis succeeded for a total number of 22 cytapheresis); and 75% after other approaches (chemotherapy based or steady state) used for patients who received bendamustine previously. Although bendamustine used alone was not an effective drug to mobilize stem cells, this agent does not seem to have detrimental effects on subsequent SCM.
authors.affiliation: a Institut D'hématologie De Basse Normandie, Centre Hospitalier Universitaire , Caen , France ;
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Gac
authors.affiliation: b Service D'hématologie Clinique, Centre Hospitalier Universitaire, La Pitié Salpetrière , Paris , France ;
authors.forename: Nabih
authors.initials: N
authors.lastname: Azar
authors.affiliation: c ervice D'hématologie Clinique, Centre Hospitalier Universitaire, Besançon, France ; Et INSERM UMR 1098, Université De Franche-Comté , Besançon , France ;
authors.forename: Etienne
authors.initials: E
authors.lastname: Daguindau
authors.affiliation: d Département D'hématologie Clinique, Centre Hospitalier Universitaire , UMR-CNRS , Montpelliers , France ;
authors.forename: Guillaume
authors.initials: G
authors.lastname: Cartron
authors.affiliation: e Service D'hématologie Clinique, Centre Hospitalier Universitaire , Strasbourg , France ;
authors.forename: Luc M
authors.initials: LM
authors.lastname: Fornecker
authors.affiliation: f Service D'hématologie Et Thérapie Cellulaire, Centre Hospitalier Universitaire , Tours , France ;
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Gyan
authors.affiliation: g Service D'hématologie Clinique, Institut Paoli Calmettes , Marseille , France ;
authors.forename: Florence
authors.initials: F
authors.lastname: Broussais-Guillaumot
authors.affiliation: h Service D'hématologie Clinique, Centre Hospitalier , Saint Quentin , France ;
authors.forename: Reda
authors.initials: R
authors.lastname: Garidi
authors.affiliation: i Service D'hématologie Clinique, Centre Hospitalier , Boulogne , France ;
authors.forename: Bachra
authors.initials: B
authors.lastname: Choufi
authors.affiliation: a Institut D'hématologie De Basse Normandie, Centre Hospitalier Universitaire , Caen , France ;
authors.forename: Sylvain P
authors.initials: SP
authors.lastname: Chantepie
authors.affiliation: j Laboratoire D'hématologie , Centre Hospitalier Universitaire , Nantes , France ;
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Béné
authors.affiliation: k Service D'hématologie Clinique Adulte Et De Thérapie Cellulaire CHU De Clermont-Ferrand, France; EA7283 - CREAT, Université D'auvergne , Clermont-Ferrand , France ;
authors.forename: Romain
authors.initials: R
authors.lastname: Guiéze
authors.affiliation: l Service D'hématologie Clinique, Institut Bergonié , Bordeaux , France ;
authors.forename: Fontanet
authors.initials: F
authors.lastname: Bijou
authors.affiliation: m Service D'hématologie Clinique, Centre Hospitalier Universitaire , Grenoble , France ;
authors.forename: Remy
authors.initials: R
authors.lastname: Gressin
authors.affiliation: n Service D'hématologie Clinique, Centre Hospitalier Universitaire , Saint Louis , Paris , France ;
authors.forename: Sandy
authors.initials: S
authors.lastname: Amorim
authors.affiliation: a Institut D'hématologie De Basse Normandie, Centre Hospitalier Universitaire , Caen , France ;|o Faculté De Médecine , Université Caen-Basse Normandie , Caen , France.
authors.forename: Gandhi
authors.initials: G
authors.lastname: Damaj
mesh_terms: D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D000069461:Bendamustine Hydrochloride / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D000072916:Peripheral Blood Stem Cells / Q000166:cytology* / Q000187:drug effects*; D019233:Retreatment; D012189:Retrospective Studies
chemical_list: D018906:Antineoplastic Agents, Alkylating; D000069461:Bendamustine Hydrochloride
keywords: Bendamustine; stem cell mobilization