title: Sasa borealis Extract Efficiently Enhanced Swimming Capacity by Improving Energy Metabolism and the Antioxidant Defense System in Mice.
abstract: This study was conducted to determine the effects of 50% ethanolic extract from Sasa borealis leaves (SBE) on swimming capacity and oxidative metabolism in mice. The mice were divided into 2 groups with similar swimming times and body weights; Ex-Control and Ex-SBE were orally administered with distilled water and 250 mg/kg body weight/d of SBE. Exhaustive swimming times were prolonged by 1.5-fold in the Ex-SBE group compared to the Ex-Control. The Ex-SBE group displayed lower lactate and higher non-esterified fatty acid levels 15 min after swimming and the hepatic and muscle glycogen levels were significantly higher than that in the Ex-Control. SBE potentially enhanced mRNA expression of citrate synthase (CS), carnitine palmitoyltransferase (CPT-1), and β-hydroxyacyl coenzyme A dehydrogenase (β-HAD) in skeletal muscle. The activities and mRNA expression of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) were elevated in the Ex-SBE compared with the Ex-Control after exhaustive swimming. These results suggest that SBE might be used as an effective agent to enhance swimming capacity by utilization of energy substrates and might ameliorate physical exhaustion by facilitating energy-generating metabolic genes and enhancing endogenous antioxidants.
authors.affiliation: Research Institute for Human Ecology, Chonnam National University.
authors.forename: Yanghee
authors.initials: Y
authors.lastname: You
authors.forename: Kyungmi
authors.initials: K
authors.lastname: Kim
authors.forename: Ho-Geun
authors.initials: HG
authors.lastname: Yoon
authors.forename: Kyung-Chul
authors.initials: KC
authors.lastname: Choi
authors.forename: Yoo-Hyun
authors.initials: YH
authors.lastname: Lee
authors.forename: Jeongmin
authors.initials: J
authors.lastname: Lee
authors.forename: Woojin
authors.initials: W
authors.lastname: Jun
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D005221:Fatigue / Q000517:prevention & control; D005227:Fatty Acids / Q000097:blood; D005979:Glutathione Peroxidase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008813:Mice, Inbred ICR; D010805:Physical Conditioning, Animal; D010807:Physical Endurance / Q000187:drug effects*; D010809:Physical Fitness; D010936:Plant Extracts / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D031787:Sasa; D013482:Superoxide Dismutase / Q000378:metabolism; D013550:Swimming / Q000502:physiology*
chemical_list: D000975:Antioxidants; D005227:Fatty Acids; D010936:Plant Extracts; D012333:RNA, Messenger; D019344:Lactic Acid; D006003:Glycogen; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase