title: GALNT14 genotype effectively predicts the therapeutic response in unresectable hepatocellular carcinoma treated with transcatheter arterial chemoembolization.
abstract: OBJECTIVE
  Transcatheter arterial chemoembolization is currently the standard treatment in hepatocellular carcinoma patients with Barcelona Clinic Liver Cancer stage B. Genomic variants of GALNT14 were recently identified as effective predictors for chemotherapy responses in Barcelona Clinic Liver Cancer stage C patients.
  
  
  METHODS
  We investigated the prognosis predictive value of GALNT14 genotypes in 327 hepatocelluar carcinoma patients treated by transcatheter arterial chemoembolization.
  
  
  RESULTS
  Cox proportional hazards model analysis showed that the genotype 'TT' was associated with shorter time-to-response (multivariate p < 0.001), time-to-complete-response (p = 0.004) and longer time-to-tumor progression (p < 0.001), compared with the genotype 'non-TT'. In patients with albumin <3.5 g/dl, genotype 'TT' was associated with longer overall survival (p = 0.027). Finally, genotype 'TT' correlated with higher cancer-to-noncancer ratios of GALNT14 protein levels, lower cancer-to-noncancer ratios of antiapoptotic cFLIP-S, and a clustered glycosylation pattern in the extracellular domain of death receptor 5.
  
  
  CONCLUSIONS
  GALNT14 genotypes were significantly associated with clinical outcomes of transcatheter arterial chemoembolization. The differential status of extrinsic apoptotic signaling between cancerous and non-cancerous tissues might underlie the clinical association.
authors.affiliation: Liver Research Center, Chang Gung Memorial Hospital, No. 5, Fu-Sing Street, Guishan Township, Taoyuan, Taiwan.|Molecular Medicine Research Center, Chang Gung University, No. 259, Wenhua 1st Rd, Guishan Dist, Taoyuan, Taiwan.
authors.forename: Kung-Hao
authors.initials: KH
authors.lastname: Liang
authors.affiliation: Liver Research Center, Chang Gung Memorial Hospital, No. 5, Fu-Sing Street, Guishan Township, Taoyuan, Taiwan.|Liver Research Unit, Keelung Chang Gung Memorial Hospital, No. 222, Maijin Road, Keelung, Taiwan.
authors.forename: Chih-Lang
authors.initials: CL
authors.lastname: Lin
authors.affiliation: Department of Chemistry, National Taiwan Normal University, No. 162, Section 1, Heping E Rd, Taipei, Taiwan.
authors.forename: Sung-Fang
authors.initials: SF
authors.lastname: Chen
authors.affiliation: Department of Chemistry, National Taiwan Normal University, No. 162, Section 1, Heping E Rd, Taipei, Taiwan.
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Chiu
authors.affiliation: Liver Research Center, Chang Gung Memorial Hospital, No. 5, Fu-Sing Street, Guishan Township, Taoyuan, Taiwan.|Molecular Medicine Research Center, Chang Gung University, No. 259, Wenhua 1st Rd, Guishan Dist, Taoyuan, Taiwan.
authors.forename: Pei-Ching
authors.initials: PC
authors.lastname: Yang
authors.affiliation: Liver Research Center, Chang Gung Memorial Hospital, No. 5, Fu-Sing Street, Guishan Township, Taoyuan, Taiwan.
authors.forename: Ming-Ling
authors.initials: ML
authors.lastname: Chang
authors.affiliation: Liver Research Center, Chang Gung Memorial Hospital, No. 5, Fu-Sing Street, Guishan Township, Taoyuan, Taiwan.
authors.forename: Chen-Chun
authors.initials: CC
authors.lastname: Lin
authors.affiliation: Liver Research Center, Chang Gung Memorial Hospital, No. 5, Fu-Sing Street, Guishan Township, Taoyuan, Taiwan.
authors.forename: Kai-Feng
authors.initials: KF
authors.lastname: Sung
authors.affiliation: Taipei American School, 800 Chung Shan North Road, Section 6, Taipei, Taiwan.
authors.forename: Cassandra
authors.initials: C
authors.lastname: Yeh
authors.affiliation: Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: Chien-Fu
authors.initials: CF
authors.lastname: Hung
authors.affiliation: Liver Research Unit, Keelung Chang Gung Memorial Hospital, No. 222, Maijin Road, Keelung, Taiwan.
authors.forename: Rong-Nan
authors.initials: RN
authors.lastname: Chien
authors.affiliation: Liver Research Center, Chang Gung Memorial Hospital, No. 5, Fu-Sing Street, Guishan Township, Taoyuan, Taiwan.|Molecular Medicine Research Center, Chang Gung University, No. 259, Wenhua 1st Rd, Guishan Dist, Taoyuan, Taiwan.
authors.forename: Chau-Ting
authors.initials: CT
authors.lastname: Yeh
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005838:Genotype; D006031:Glycosylation; D006801:Humans; D007261:Infusions, Intra-Arterial; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017350:N-Acetylgalactosaminyltransferases / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies; D059016:Tumor Microenvironment
chemical_list: D000903:Antibiotics, Antineoplastic; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D004317:Doxorubicin; D017350:N-Acetylgalactosaminyltransferases; C471038:UDP-N-acetyl-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 14, human
keywords: O-glycosylation; apoptosis; death receptor; sorafenib