title: A 3D Homochiral MOF [Cd2(d-cam)3]•2Hdma•4dma for HPLC Chromatographic Enantioseparation.
abstract: Up to now, some chiral metal-organic frameworks (MOFs) have been reported for enantioseparation in liquid chromatography. Here we report a homochiral MOF, [Cd2(d-cam)3]·2Hdma·4dma, used as a new chiral stationary phase for high-performance liquid chromatographic enantioseparation. Nine racemates of alcohol, naphthol, ketone, and base compounds were used as analytes for evaluating the separation properties of the chiral MOF packed column. Moreover, some effects such as mobile phase composition, column temperature, and analytes mass for separations on this chiral column also were investigated. The relative standard deviations for the resolution values of run-to-run and column-to-column were less than 2.1% and 3.2%, respectively. The experimental results indicate that the homochiral MOF offered good recognition ability, which promotes the application of chiral MOFs use as stationary phase for enantioseparation.
authors.affiliation: Department of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, P. R. China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Agricultural Science Research Institute of Quality Standards and Testing Technology Institute of Yunnan Province, Kunming, P. R. China.
authors.forename: Xinglian
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Chemistry, East China Normal University, Shanghai, P. R. China.
authors.forename: Junhui
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Kong
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
authors.forename: Liming
authors.initials: L
authors.lastname: Yuan
mesh_terms: D002104:Cadmium / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002853:Chromatography, Liquid; D013237:Stereoisomerism
chemical_list: D002104:Cadmium
keywords: chiral stationary phase; enantioseparation; high-performance liquid chromatography; metal-organic frameworks; racemates