title: Circulating Interferon-Gamma Levels Are Associated with Low Body Weight in Newly Diagnosed Kenyan Non-Substance Using Tuberculosis Individuals.
abstract: Although interferon-gamma, interleukin-10, and adiponectin are key immunopathogenesis mediators of tuberculosis, their association with clinical manifestations of early stage disease is inconclusive. We determined interferon-gamma, interleukin-10, and adiponectin levels in clinically and phenotypically well-characterised non-substance using new pulmonary tuberculosis patients (n = 13) and controls (n = 14) from Kenya. Interferon-gamma levels (P < 0.0001) and interferon-gamma to interleukin-10 (P < 0.001) and interferon-gamma to adiponectin (P = 0.027) ratios were elevated in tuberculosis cases. Correlation analyses in tuberculosis cases showed associations of interferon-gamma levels with body weight (ρ = -0.849; P < 0.0001), body mass index (ρ = 0.664; P = 0.013), hip girth (ρ = -0.579; P = 0.038), and plateletcrit (ρ = 0.605; P = 0.028); interferon-gamma to interleukin-10 ratio with diastolic pressure (ρ = -0.729; P = 0.005); and interferon-gamma to adiponectin ratio with body weight (ρ = -0.560; P = 0.047), body mass index (ρ = -0.604; P = 0.029), and plateletcrit (ρ = 0.793; P = 0.001). Taken together, our results suggest mild-inflammation in early stage infection characterised by upregulation of circulating interferon-gamma production in newly infected TB patients.
authors.affiliation: Department of Medical Laboratory Sciences, Masinde Muliro University of Science and Technology, P.O. Box 190, Kakamega 50100, Kenya.
authors.forename: Nathan
authors.initials: N
authors.lastname: Shaviya
authors.affiliation: Department of Environment and Health Sciences, Technical University of Mombasa, Mombasa, Kenya.
authors.forename: Valentine
authors.initials: V
authors.lastname: Budambula
authors.affiliation: Department of Medical Laboratory Sciences, Masinde Muliro University of Science and Technology, P.O. Box 190, Kakamega 50100, Kenya.
authors.forename: Mark K
authors.initials: MK
authors.lastname: Webale
authors.affiliation: Department of Medical Laboratory Sciences, Masinde Muliro University of Science and Technology, P.O. Box 190, Kakamega 50100, Kenya.
authors.forename: Tom
authors.initials: T
authors.lastname: Were