title: Molecular mechanisms underlying chemopreventive potential of curcumin: Current challenges and future perspectives.
abstract: In recent years, natural compounds have received considerable attention in preventing and curing most dreadful diseases including cancer. The reason behind the use of natural compounds in chemoprevention is associated with fewer numbers of side effects than conventional chemotherapeutics. Curcumin (diferuloylmethane, PubMed CID: 969516), a naturally occurring polyphenol, is derived from turmeric, which is used as a common Indian spice. It governs numerous intracellular targets, including proteins involved in antioxidant response, immune response, apoptosis, cell cycle regulation and tumor progression. A huge mass of available studies strongly supports the use of Curcumin as a chemopreventive drug. However, the main challenge encountered is the low bioavailability of Curcumin. This extensive review covers various therapeutic interactions of Curcumin with its recognized cellular targets involved in cancer treatment, strategies to overcome the bioavailability issue and adverse effects associated with Curcumin consumption.
authors.affiliation: Department of Biochemistry, Delhi University, South Campus, New Delhi, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kumar
authors.affiliation: School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.
authors.forename: Sonam
authors.initials: S
authors.lastname: Mittal
authors.affiliation: Department of Hematology and Oncology, University of Tartu, Estonia.
authors.forename: Katrin
authors.initials: K
authors.lastname: Sak
authors.affiliation: Department of Biotechnology, Maharishi Markandeshwar University, Mulana-Ambala, India. Electronic address: hardeep.biotech@gmail.com.
authors.forename: Hardeep Singh
authors.initials: HS
authors.lastname: Tuli
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D003474:Curcumin / Q000494:pharmacology / Q000627:therapeutic use*; D005544:Forecasting; D006801:Humans; D051336:Mitochondrial Membranes / Q000187:drug effects / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D003474:Curcumin
keywords: Angiogenesis; Anti-cancer action; Apoptosis; Curcumin; Toxicity profile