title: Model reduction of the intracellular-signaling subsystem of apoptosis.
abstract: In recent few decades numerical treatment has become a standard tool in the system analysis and investigation of complex chemical reactions networks of reacting flows. The information about certain networks of biochemical reactions constantly increases. This leads to detailed descriptions of biochemical processes as a system of differential equations of high complexity and dimension. Nowadays methods, which are able automatically reduce the system dimension and complexity, are highly desirable. Recently several methods were developed for model reduction in combustion and chemical kinetics aiming at automatic numerical treatment and constructing the reduced system. The reduced system represents reliable description reproducing the detailed system behavior accurately enough. In this work the method of qualitative ODEs system analysis and the global quasi-linearization method (GQL) for kinetic mechanism reduction of combustion models are applied to the biochemical reaction network of the apoptosis. It is shown that the original model of the apoptosis can be essentially simplified firstly by using linear system integrals (9 dimensions) of the ODEs system, secondly the results of GQL analysis reveals the possibility of a further reduction (4 dimensions). It means that the final system dimension reaches 15 compare to the original 28 without any noticeable accuracy losses.
authors.affiliation: Karlsruher Institut für Technologie (KIT), Institut für Technische Thermodynamik (ITT), Engelbert-Arndold-Straße 4, Geb. 10.91, 76131 Karlsruhe, Germany . Electronic address: Viatcheslav.Bykov@kit.edu.
authors.forename: V
authors.initials: V
authors.lastname: Bykov
authors.affiliation: Department of Mathematics, Ben Gurion University of the Negev, P.O.B. 653, Beer-Sheva 84105, Israel.
authors.forename: V
authors.initials: V
authors.lastname: Gol'dshtein
mesh_terms: D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D006801:Humans; D016014:Linear Models; D055641:Mathematical Concepts; D008954:Models, Biological; D015398:Signal Transduction; D019014:fas Receptor / Q000378:metabolism
chemical_list: C491901:FAS protein, human; D019014:fas Receptor; D020169:Caspases
keywords: Apoptosis; Biochemical reactions; GQL; Model reduction