title: Persistent Organic Nanopores Amenable to Structural and Functional Tuning.
abstract: Rigid macrocycles 2, which share a hybrid backbone and the same set of side chains while having inner cavities with different inward-pointing functional groups, undergo similar nanotubular assembly as indicated by multiple techniques including (1)H NMR, fluorescence spectroscopy, and atomic force microscopy. The formation of tubular assemblies containing subnanometer pores is also attested by the different transmembrane ion-transport behavior observed for these macrocycles. Vesicle-based stopped-flow kinetic assay and single-channel electrophysiology with planar lipid bilayers show that the presence of an inward-pointing functional (X) group in the inner cavity of a macrocyclic building block exerts a major influence on the transmembrane ion-transporting preference of the corresponding self-assembling pore. Self-assembling pores with inward-pointing amino and methyl groups possess the surprising and remarkable capability of rejecting protons but are conducive to transporting larger ions. The inward-pointing groups also resulted in transmembrane pores with a different extent of positive electrostatic potentials, leading to channels having different preferences for transporting chloride ion. Results from this work demonstrate that synthetic modification at the molecular level can profoundly impact the property of otherwise structurally persistent supramolecular assemblies, with both expected tunability and suprisingly unusual behavior.
authors.affiliation: College of Chemistry, Beijing Normal University , Beijing 100875, China.|Department of Chemistry, The State University of New York at Buffalo , Buffalo, New York 14260, United States.
authors.forename: Xiaoxi
authors.initials: X
authors.lastname: Wei
authors.affiliation: College of Chemistry, Beijing Normal University , Beijing 100875, China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University , Shanghai 200240, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shen
authors.affiliation: College of Chemistry, Beijing Normal University , Beijing 100875, China.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: College of Chemistry, Beijing Normal University , Beijing 100875, China.|Department of Chemistry, The State University of New York at Buffalo , Buffalo, New York 14260, United States.
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.affiliation: College of Chemistry, Beijing Normal University , Beijing 100875, China.
authors.forename: Na
authors.initials: N
authors.lastname: Yang
authors.affiliation: Department of Chemistry, The State University of New York at Buffalo , Buffalo, New York 14260, United States.
authors.forename: Fayez Y
authors.initials: FY
authors.lastname: Al-Mkhaizim
authors.affiliation: Department of Chemistry, The State University of New York at Buffalo , Buffalo, New York 14260, United States.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Kline
authors.affiliation: National Institute for Food and Drug Control , Beijing 100050, China.
authors.forename: Lan
authors.initials: L
authors.lastname: He
authors.affiliation: College of Chemistry, Beijing Normal University , Beijing 100875, China.
authors.forename: Minfeng
authors.initials: M
authors.lastname: Li
authors.affiliation: College of Chemistry, Beijing Normal University , Beijing 100875, China.
authors.forename: Zhong-Lin
authors.initials: ZL
authors.lastname: Lu
authors.affiliation: Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University , Shanghai 200240, China.
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Shao
authors.affiliation: College of Chemistry, Beijing Normal University , Beijing 100875, China.|Department of Chemistry, The State University of New York at Buffalo , Buffalo, New York 14260, United States.
authors.forename: Bing
authors.initials: B
authors.lastname: Gong