title: Analysis of the diagnostic efficiency of serum oxidative stress parameters in patients with breast cancer at various clinical stages.
abstract: BACKGROUND
  Reactive oxygen species (ROS) are balanced through enzymatic mechanisms and exogenous antioxidants; imbalance results in oxidative stress (OxS). It is known that OxS plays an important role in the occurrence, development, and metastasis of breast cancer. The present study aimed to assess serum total oxidant status (TOS), total antioxidant status (TAS), and oxidant stress index (OSI) in patients at different clinical stages of breast cancer and to evaluate their diagnostic accuracy.
  
  
  METHODS
  Serum TOS, TAS, and OSI were determined in 91 patients with breast cancer at different stages, 51 patients with benign breast tumors, and 35 healthy adults.
  
  
  RESULTS
  Significant differences in serum TOS (F=104.384, p=0.000), TAS (F=18.247, p=0.000), and OSI (F=62.598, p=0.000) were observed among the 3 groups (benign breast tumor patients, breast cancer patients, and healthy women). Of the enrolled breast cancer patients, significant differences were also observed among different tumor stages, with TOS and OSI gradually increasing as the disease progressed, while TAS diminished. Receiver operating characteristic curve analysis revealed that the area under the ROC curve for OSI (AUCOSI) was significantly higher than AUCTAS (z=2.344, p=0.019) in distinguishing breast cancer from control groups (including disease control and the healthy control). The AUCOSI (z=4.700, p=0.001) or AUCTOS (z=4.700, p=0.001) was significantly higher than AUCTAS in distinguishing breast cancer from the healthy control. The AUCOSI (z=5.907, p=0.000) or AUCTOS (z=5.667, p=0.000) was significantly higher than AUCTAS in distinguishing benign breast tumors from the healthy control.
  
  
  CONCLUSIONS
  Oxidative stress parameters might serve as important indexes for monitoring breast cancer occurrence and progression. The combined evaluation of TOS, TAS, and OSI could be more beneficial for clinical assessment.
authors.affiliation: Department of Laboratory Medicine, Mianyang Central Hospital, Sichuan 621000, China. Electronic address: jiafufeng@aliyun.com.
authors.forename: Jia-Fu
authors.initials: JF
authors.lastname: Feng
authors.affiliation: Department of Obstetrics and Gynecology, Mianyang Central Hospital, Sichuan 621000, China. Electronic address: linglu612@163.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Laboratory Medicine, Mianyang Central Hospital, Sichuan 621000, China. Electronic address: 313314793@qq.com.
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Dai
authors.affiliation: Department of Oncology, Mianyang Central Hospital, Sichuan 621000, China. Electronic address: mychml2007@aliyun.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Pathology, Mianyang Central Hospital, Sichuan 621000, China. Electronic address: yunhongyang625@yahoo.cn.
authors.forename: Yun-Hong
authors.initials: YH
authors.lastname: Yang
authors.affiliation: Department of Laboratory Medicine, Mianyang Central Hospital, Sichuan 621000, China. Electronic address: yyw318@vip.sian.com.
authors.forename: Yu-Wei
authors.initials: YW
authors.lastname: Yang
authors.affiliation: Department of Laboratory Medicine, Mianyang Central Hospital, Sichuan 621000, China. Electronic address: yunshuang1964@sina.cn.
authors.forename: Yun-Shuang
authors.initials: YS
authors.lastname: Liu
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000145:classification* / Q000175:diagnosis* / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009367:Neoplasm Staging; D016877:Oxidants / Q000378:metabolism*; D018384:Oxidative Stress; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D017382:Reactive Oxygen Species / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D000975:Antioxidants; D014408:Biomarkers, Tumor; D016877:Oxidants; D017382:Reactive Oxygen Species; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human
keywords: Breast neoplasms; Oxidative stress; Total antioxidant status; Total oxidant status