title: [Impact of statin therapy on recurrence of persistent atrial fibrillation after electrical cardioversion: a meta-analysis].
abstract: OBJECTIVE
  To evaluate the impact of statin therapy on the recurrence rate in patients with persistent atrial fibrillation (AF) after electrical cardioversion.
  
  
  METHODS
  PubMed, EMBbase, Cochrane central register of controlled trials were searched up to February 2015 to identify randomized controlled trials, which reported the effect of statin therapy on AF recurrence after electrical cardioversion. The data were analyzed by RevMan 5.3 and Stata 12.0 software.
  
  
  RESULTS
  Six trials with 572 patients were included. The result showed that statin therapy had no effect on the recurrence rate in patients with persistent AF after electrical cardioversion (OR=0.60, 95%CI: 0.32-1.11, P>0.05) compared with controls. Four out of the six trials investigated the effect of atorvastatin on the recurrence rate of AF after electrical cardioversion, subgroup analysis of these trials showed that compared with controls, atorvastatin had no effect on the recurrence of AF after electrical cardioversion (OR=0.59, 95%CI: 0.25-1.39, P>0.05). Three out of the six trials had high quality (Jadad score≥3), subgroup analysis of these trials also showed that statins did not affect the recurrence rate of AF after electrical cardioversion (OR=0.76, 95%CI: 0.49-1.16, P>0.05).
  
  
  CONCLUSIONS
  This analysis suggested that statin therapy had no effect on the recurrence rate in patients with persistent AF after electrical cardioversion.
authors.affiliation: Heart Center, Hebei General Hospital, Shijiazhuang 050051, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Heart Center, Hebei General Hospital, Shijiazhuang 050051, China; Email: hbghxiaoyong_q@126.com.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Qi
authors.affiliation: Heart Center, Hebei General Hospital, Shijiazhuang 050051, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dang
authors.affiliation: Heart Center, Hebei General Hospital, Shijiazhuang 050051, China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Song
authors.affiliation: Heart Center, Hebei General Hospital, Shijiazhuang 050051, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Hao
mesh_terms: D000069059:Atorvastatin; D001281:Atrial Fibrillation; D004554:Electric Countershock; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000069059:Atorvastatin