title: Genetic Testing in Hyperlipidemia.
abstract: Hereditary dyslipidemias are often underdiagnosed and undertreated, yet with significant health implications, most importantly causing preventable premature cardiovascular diseases. The commonly used clinical criteria to diagnose hereditary lipid disorders are specific but are not very sensitive. Genetic testing may be of value in making accurate diagnosis and improving cascade screening of family members, and potentially, in risk assessment and choice of therapy. This review focuses on using genetic testing in the clinical setting for lipid disorders, particularly familial hypercholesterolemia.
authors.affiliation: Department of Medicine, Baylor College of Medicine, 3131 Fannin Street, Houston, TX 77030, USA.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Bilen
authors.affiliation: Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, Suite B157, Houston, TX 77030, USA; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, 6565 Fannin Street, M.S. A-601, Houston, TX 77030, USA.
authors.forename: Yashashwi
authors.initials: Y
authors.lastname: Pokharel
authors.affiliation: Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, 6565 Fannin Street, M.S. A-601, Houston, TX 77030, USA; Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, M.S. A-601, Suite 656, Houston, TX 77030, USA; Section of Cardiology, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, M.S. A-601, Suite 656, Houston, TX 77030, USA. Electronic address: cmb@bcm.edu.
authors.forename: Christie M
authors.initials: CM
authors.lastname: Ballantyne
keywords: Dyslipidemia; Familial hypercholesterolemia; Genetic testing; Hereditary lipid disorder