title: Wnt-YAP interactions in the neural fate of human pluripotent stem cells and the implications for neural organoid formation.
abstract: Human pluripotent stem cells (hPSCs) have shown the ability to self-organize into different types of neural organoids (e.g., whole brain organoids, cortical spheroids, midbrain organoids etc.) recently. The extrinsic and intrinsic signaling elicited by Wnt pathway, Hippo/Yes-associated protein (YAP) pathway, and extracellular microenvironment plays a critical role in brain tissue morphogenesis. This article highlights recent advances in neural tissue patterning from hPSCs, in particular the role of Wnt pathway and YAP activity in this process. Understanding the Wnt-YAP interactions should provide us the guidance to predict and modulate brain-like tissue structure through the regulation of extracellular microenvironment of hPSCs.
authors.affiliation: a Department of Chemical and Biomedical Engineering , FAMU-FSU College of Engineering, Florida State University , Tallahassee , FL , USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Bejoy
authors.affiliation: a Department of Chemical and Biomedical Engineering , FAMU-FSU College of Engineering, Florida State University , Tallahassee , FL , USA.
authors.forename: Liqing
authors.initials: L
authors.lastname: Song
authors.affiliation: a Department of Chemical and Biomedical Engineering , FAMU-FSU College of Engineering, Florida State University , Tallahassee , FL , USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D006801:Humans; D055495:Neurogenesis / Q000502:physiology*; D009940:Organoids / Q000378:metabolism / Q000502:physiology; D010750:Phosphoproteins / Q000378:metabolism*; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D014157:Transcription Factors; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000502:physiology*; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D051153:Wnt Proteins; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human
keywords: Wnt; YAP; neural organoid; pluripotent stem cell; three-dimensional