title: [Analysis of the curative effect of intralesional steroid injection combined with acid-suppressive therapy for laryngeal contact granuloma].
abstract: OBJECTIVE
  To study the efficacy of intralesional steroid injection combined with acid-suppressive therapy for laryngeal contact granuloma.
  
  
  METHODS
  Eighty eight patients with laryngeal contact granuloma diagnosed from March 2010 to October 2014 were reviewed.Twenty-one patients took intralesional steroid injection combined with acid-suppressive therapy as experimental group (4 patients in initial treatment group, 17 patients in non-initial treatment group), other 67 patients only received acid-suppressive therapy as control group. The clinical data of these patients was analyzed.
  
  
  RESULTS
  In experimental group, 15 patients were cured (71.43%) and the average cure time were (3.80±0.43) months, total injection time was 2-6 times and the median was 3 times. In control group, 50 patients were cured (74.63%) and the average cure time were (5.31±0.38) months. No any systemic and local complications were found in all the patients during the follow-up period of 6-42 months. The cure rate had no significant difference between the experimental group and control group, but the cure time in the former group was shorter than that in the latter group (Z=-2.093, P=0.036). In the experimental group, the initial treatment patients had no significant difference in cure rate and cure time compared with non initial patients (χ(2)=1.112, P=0.544; Z=0.000, P=1.000).
  
  
  CONCLUSIONS
  Intralesional steroid injection combined with acid-suppressive therapy can be recommended as a safe and effective alternative therapy for laryngeal contact granuloma, especially the refractory granuloma.
authors.affiliation: Department of Otorhinolarnygology Head and Neck Surgery, Navy General Hospital, Beijing 100048, China.
authors.forename: S Y
authors.initials: SY
authors.lastname: Tian
authors.affiliation: Department of Otorhinolarnygology Head and Neck Surgery, Navy General Hospital, Beijing 100048, China.
authors.forename: J R
authors.initials: JR
authors.lastname: Li
authors.affiliation: Department of Otorhinolarnygology Head and Neck Surgery, Navy General Hospital, Beijing 100048, China.
authors.forename: P F
authors.initials: PF
authors.lastname: Guo
authors.affiliation: Department of Otorhinolarnygology Head and Neck Surgery, Navy General Hospital, Beijing 100048, China.
authors.forename: K L
authors.initials: KL
authors.lastname: Li
authors.affiliation: Department of Otorhinolarnygology Head and Neck Surgery, Navy General Hospital, Beijing 100048, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
mesh_terms: D003131:Combined Modality Therapy; D006102:Granuloma, Laryngeal / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D013256:Steroids / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013256:Steroids