title: Fecal Lipid Excretion after Consumption of a Black Tea Polyphenol Containing Beverage-Randomized, Placebo-Controlled, Double-Blind, Crossover Study.
abstract: Obesity is a serious medical condition worldwide. Inhibition of lipid absorption is very important in preventing obesity. In a previous study, we found that postprandial elevation of triacylglycerol was suppressed by the intake of black tea polyphenol (BTP). We also reported that BTP caused lipid excretion into feces in an animal study. The present study is a clinical trial that examined lipid excretion. In this randomized, placebo-controlled, double-blind, crossover study, in the first test period participants were asked to drink either a beverage containing 55 mg BTP or a control beverage without BTP 3 times a day for 10 d. After an 11-d interval, for the second test period, they then drank the alternate test beverage 3 times a day for 10 d. During the test periods, the participants were asked to eat meals standardized according to calorie and fat content. Stool samples were obtained during the last 3 d of each test period for fecal lipid measurements. Total lipid excretion increased from 5.51±1.73 to 6.87±1.91 g/3 d after BTP intake in comparison with intake of the control beverage. These results indicated that BTP increased lipid excretion.
authors.affiliation: Research Laboratories for Health Science & Food Technologies, Kirin Co., Ltd.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ashigai
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: Mihoko
authors.initials: M
authors.lastname: Suzuki
authors.forename: Emiko
authors.initials: E
authors.lastname: Ikeshima
authors.forename: Tomoka
authors.initials: T
authors.lastname: Kanaya
authors.forename: Kanako
authors.initials: K
authors.lastname: Zembutsu
authors.forename: Shimpei
authors.initials: S
authors.lastname: Tomita
authors.forename: Mika
authors.initials: M
authors.lastname: Miyake
authors.forename: Ikuo
authors.initials: I
authors.lastname: Fukuhara
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000493:pharmacokinetics*; D004311:Double-Blind Method; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D059808:Polyphenols / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*; D055815:Young Adult
chemical_list: D004041:Dietary Fats; D059808:Polyphenols; D013662:Tea