title: Multiple Sclerosis Epidemiology in East Asia, South East Asia and South Asia: A Systematic Review.
abstract: BACKGROUND
  Multiple sclerosis (MS) is one of the most common chronic immune-mediated diseases of the human central nervous system and an important cause of non-traumatic neurologic disability among young population in several countries. Recent reports from East Asia, South East Asia and South Asia have proposed a low to moderate prevalence of MS in these countries.
  
  
  METHODS
  A literature review search was carried out in December 2014 in Medline, Embase, Scopus and Cochrane library to recover original population-based studies on MS epidemiology in East Asia, South East Asia and South Asia countries published between January 1, 1950 and December 30, 2014. We intended search strategies using the key words: multiple sclerosis, prevalence, incidence and epidemiology. Based on our inclusion criteria, 68 epidemiologic studies were included in this systematic review.
  
  
  RESULTS
  The most extensively used diagnostic criteria in the studies were McDonald's criteria. Most studies were performed in a multi-center hospital setting. The female to male ratio varied and ranged from 0.7 in India to 9.0 in China. The mean age at disease onset ranged from the lowest age of 25.3 in Iran to the highest age of 46.4 in China. MS prevalence ranged from 0.77 in 100,000 populations in Hong Kong (1999) to 85.80 in 100,000 in Iran (2013).
  
  
  CONCLUSIONS
  Advances in MS registries around the globe allow nationwide population-based studies and will allow worldly comparisons between the prevalence and incidence in different regions that are provided to monitor estimation.
authors.affiliation: MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sharareh
authors.initials: S
authors.lastname: Eskandarieh
authors.forename: Pouria
authors.initials: P
authors.lastname: Heydarpour
authors.forename: Alireza
authors.initials: A
authors.lastname: Minagar
authors.forename: Shadi
authors.initials: S
authors.lastname: Pourmand
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Sahraian
mesh_terms: D001210:Asia, Southeastern / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005202:Asia, Eastern / Q000453:epidemiology; D006801:Humans; D009103:Multiple Sclerosis / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology*; D012189:Retrospective Studies