title: Clinical Abacavir Hypersensitivity Reaction among Children in India.
abstract: Abacavir is currently recommended as a part of first line regimen by National AIDS Control Organization. The objective of this study was to observe the incidence of clinically diagnosed abacavir Hypersensitivity reaction (HSR) among children on abacavir based therapy in the National program. In this observational study, all children started on abacavir were included and HSR reaction was diagnosed clinically as per National guidelines. HLA- B*5701 testing was done in children diagnosed with clinical abacavir HSR. Among 101 children started on abacavir during the study period, 8 [7.9 % (95 % CI 3.5-15.0 %)] children developed clinically diagnosed abacavir HSR. All children with concomitant illness (4/8) were HLA-B*5701 negative. Only 2 (25 %, 2/8) carried HLA-B*5701 allele. Fever with abdominal symptoms as compared to respiratory symptoms were more common in HLA-B*5701 positive cases. Overdiagnosis of clinically diagnosed abacavir HSR is common and could be decreased by treating concomitant illness before starting abacavir.
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India. tapadar@gmail.com.
authors.forename: Jaya
authors.initials: J
authors.lastname: Chakravarty
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Johri
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
authors.forename: Ankita
authors.initials: A
authors.lastname: Chourasia
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
authors.forename: Shyam
authors.initials: S
authors.lastname: Sundar
mesh_terms: D019380:Anti-HIV Agents; D002648:Child; D002675:Child, Preschool; D015224:Dideoxynucleosides / Q000009:adverse effects*; D004342:Drug Hypersensitivity; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D007194:India; D008297:Male; D000099227:Abacavir
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D000099227:Abacavir
keywords: Abacavir; Antiretroviral therapy; HIV; HLA-B*5701; Hypersensitivity reaction