title: Successful treatment of rapidly progressing severe fever with thrombocytopenia syndrome with neurological complications using intravenous immunoglobulin and corticosteroid.
abstract: Since the first report of severe fever with thrombocytopenia syndrome (SFTS) in China, diagnostic methods have evolved. Despite definitive diagnoses, SFTS management has focused on prevention and supportive care. Although conservative treatment is effective for mild cases, there is an urgent need for an effective therapeutic modality to treat severe cases because of the high mortality associated with these. In this study, we report two cases of SFTS with neurological manifestations that fully recovered after a combination treatment consisting of intravenous immunoglobulin and corticosteroid.
authors.affiliation: Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Uh Jin
authors.initials: UJ
authors.lastname: Kim
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Republic of Korea.
authors.forename: Dong-Min
authors.initials: DM
authors.lastname: Kim
authors.affiliation: Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Joon Hwan
authors.initials: JH
authors.lastname: Ahn
authors.affiliation: Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Seung-Ji
authors.initials: SJ
authors.lastname: Kang
authors.affiliation: Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Hee-Chang
authors.initials: HC
authors.lastname: Jang
authors.affiliation: Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Kyung-Hwa
authors.initials: KH
authors.lastname: Park
authors.affiliation: Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Sook In
authors.initials: SI
authors.lastname: Jung
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000368:Aged; D002044:Bunyaviridae Infections / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D016856:Phlebovirus; D013921:Thrombocytopenia / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D016756:Immunoglobulins, Intravenous