title: Construction of pH-responsive and up-conversion luminescent NaYF₄:Yb³⁺/Er³⁺@SiO₂@PMAA nanocomposite for colon targeted drug delivery.
abstract: Colon-targeted drug delivery system has attracted much interest because it can improve therapeutic efficacy and reduce the side effect in practical clinic. Herein, we constructed a multifunctional drug delivery system with colonic targeting and tracking by up-conversion (UC) luminescence based on core-shell structured NaYF4:Yb(3+)/Er(3+)@SiO2@PMAA nanocomposite. The resultant materials exhibited bright UC luminescence, pH-responsive property and excellent biocompatibility. The drug release behaviors in different pH environment were investigated using 5-aminosalicylic acid (5-ASA) as a model drug. The 5-ASA molecules release from NaYF4:Yb(3+)/Er(3+)@SiO2@PMAA nanocomposite exhibit a significant pH-responsive colon targeted property, i.e., a little amount of drug release in simulated gastric fluid (SGF, pH = 1.2) but a large amount of drug release in simulated colonic fluid (SCF, pH = 7.4) Moreover, the drug release process could be monitored by the change of UC emission intensity. These results implied that the multifunctional nanocomposite is a promising drug carrier for targeted release of 5-ASA in the colon.
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou 466001, P. R. China.
authors.forename: Boshi
authors.initials: B
authors.lastname: Tian
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou 466001, P. R. China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Liu
authors.affiliation: University Research Facility in Materials Characterization and Device Fabrication, The Hong Kong Polytechnic University, Hong Kong, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou 466001, P. R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Jin
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou 466001, P. R. China.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Li
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou 466001, P. R. China.
authors.forename: Yurong
authors.initials: Y
authors.lastname: Shi
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou 466001, P. R. China.
authors.forename: Chunyang
authors.initials: C
authors.lastname: Li
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou 466001, P. R. China.
authors.forename: Zhenling
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Frontier Institute of Science and Technology Jointly with College of Science, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Du
mesh_terms: D000636:Aminosalicylic Acids / Q000008:administration & dosage; D002470:Cell Survival; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004871:Erbium / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D049449:Luminescence; D053761:Nanocomposites / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013997:Time Factors; D015018:Ytterbium / Q000737:chemistry*
chemical_list: D000636:Aminosalicylic Acids; D004337:Drug Carriers; D012822:Silicon Dioxide; D004871:Erbium; D015018:Ytterbium