title: Biomaterials based on N,N,N-trimethyl chitosan fibers in wound dressing applications.
abstract: In the present work, N,N,N-trimethyl chitosan (TMC) fibers were synthesized successfully and the resulting quaternized materials were characterized by FTIR. The designed TMC fibers with different degree of quaternization achieved high water absorption capability. In antibacterial activity study, TMC fibers showed high antibacterial activity than chitosan fibers against the gram-negative bacteria Escherichia coli (>63%) and gram-positive bacteria Staphylococcus aureus (>99%). TMC fibers exhibited no obvious cytotoxicity to mouse embryo fibroblast cells with low extraction concentrations (<0.05g/mL). In animal wound healing test, TMC2 fibers could significantly enhance wound re-epithelialization and contraction compared with the control (chitosan fibers). In conclusion, TMC fibers have a potential to be used as wound dressing materials.
authors.affiliation: College of Marine Life Science, Ocean University of China, 5 Yushan Road, 266003 Qingdao, PR China.
authors.forename: Zhongzheng
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: College of Marine Life Science, Ocean University of China, 5 Yushan Road, 266003 Qingdao, PR China.
authors.forename: Dong
authors.initials: D
authors.lastname: Yan
authors.affiliation: College of Marine Life Science, Ocean University of China, 5 Yushan Road, 266003 Qingdao, PR China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Cheng
authors.affiliation: College of Marine Life Science, Ocean University of China, 5 Yushan Road, 266003 Qingdao, PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Kong
authors.affiliation: College of Marine Life Science, Ocean University of China, 5 Yushan Road, 266003 Qingdao, PR China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Marine Life Science, Ocean University of China, 5 Yushan Road, 266003 Qingdao, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Feng
authors.affiliation: College of Marine Life Science, Ocean University of China, 5 Yushan Road, 266003 Qingdao, PR China. Electronic address: xgchen@ouc.edu.cn.
authors.forename: Xiguang
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000627:therapeutic use; D001458:Bandages; D048271:Chitosan / Q000737:chemistry* / Q000627:therapeutic use; D004926:Escherichia coli / Q000187:drug effects / Q000472:pathogenicity; D006801:Humans; D051379:Mice; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects / Q000472:pathogenicity; D014867:Water / Q000737:chemistry; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; C118071:N-trimethyl chitosan chloride; D014867:Water; D048271:Chitosan
keywords: Antibacterial activity; N,N,N-Trimethyl chitosan fibers; Wound dressing; Wound healing