title: Postoperative administration of dienogest for suppressing recurrence of disease and relieving pain in subjects with ovarian endometriomas.
abstract: To assess the effect of dienogest on recurrence of ovarian endometriomas and severity of pain after laparoscopic surgery, a retrospective study of 81 patients was performed at three institutions in Osaka, Japan. Patients had a six-month minimum follow-up after laparoscopic surgery for ovarian endometriomas performed between June 2012 and August 2014. Patients who chose to receive 2 mg dienogest daily and those who were managed expectantly postoperatively were included. Recurrence was defined as the presence of endometriomas of more than 2 cm. A visual analog scale (VAS) was used to score the intensity of pelvic pain. The cumulative recurrence rate and absolute VAS score changes between the baseline and at 6, 12, 18 and 24 months after the start of administration were evaluated in both groups. The recurrence rate was 16.5% and 24.0% in the expectant management group at 12 and 24 months, respectively. No recurrences occurred in the dienogest treatment group. The rate of VAS score reduction was significantly higher in the dienogest than in the expectant management group. Dienogest is effective on the recurrence of ovarian endometrioma and relieving pelvic pain after laparoscopic surgery.
authors.affiliation: a Department of Obstetrics and Gynecology , Minoh City Hospital , Osaka , Japan.
authors.forename: Kazushige
authors.initials: K
authors.lastname: Adachi
authors.affiliation: a Department of Obstetrics and Gynecology , Minoh City Hospital , Osaka , Japan.
authors.forename: Kayo
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: b Department of Obstetrics and Gynecology , Osaka University Graduate School of Medicine , Osaka , Japan , and.
authors.forename: Koji
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: a Department of Obstetrics and Gynecology , Minoh City Hospital , Osaka , Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Otake
authors.affiliation: a Department of Obstetrics and Gynecology , Minoh City Hospital , Osaka , Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Sasamoto
authors.affiliation: a Department of Obstetrics and Gynecology , Minoh City Hospital , Osaka , Japan.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Miyoshi
authors.affiliation: a Department of Obstetrics and Gynecology , Minoh City Hospital , Osaka , Japan.
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Shioji
authors.affiliation: a Department of Obstetrics and Gynecology , Minoh City Hospital , Osaka , Japan.
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: c Department of Obstetrics and Gynecology , Toyonaka City Hospital , Osaka , Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Fujitani
authors.affiliation: c Department of Obstetrics and Gynecology , Toyonaka City Hospital , Osaka , Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Wakimoto
authors.affiliation: c Department of Obstetrics and Gynecology , Toyonaka City Hospital , Osaka , Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tokuhira
authors.affiliation: b Department of Obstetrics and Gynecology , Osaka University Graduate School of Medicine , Osaka , Japan , and.
authors.forename: Eiji
authors.initials: E
authors.lastname: Kobayashi
authors.affiliation: b Department of Obstetrics and Gynecology , Osaka University Graduate School of Medicine , Osaka , Japan , and.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshimura
authors.affiliation: b Department of Obstetrics and Gynecology , Osaka University Graduate School of Medicine , Osaka , Japan , and.
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Sawada
authors.affiliation: b Department of Obstetrics and Gynecology , Osaka University Graduate School of Medicine , Osaka , Japan , and.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kimura
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D004715:Endometriosis / Q000188:drug therapy* / Q000517:prevention & control / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006727:Hormone Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007564:Japan; D010535:Laparoscopy; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D017063:Outcome Assessment, Health Care; D010049:Ovarian Diseases / Q000188:drug therapy* / Q000517:prevention & control / Q000601:surgery; D010147:Pain Measurement; D017699:Pelvic Pain / Q000188:drug therapy* / Q000517:prevention & control / Q000601:surgery; D012008:Recurrence; D012189:Retrospective Studies
chemical_list: D006727:Hormone Antagonists; C023635:dienogest; D009277:Nandrolone
keywords: Dienogest; laparoscopic surgery; ovarian endometrioma