title: JCL roundtable: PCSK9 inhibitors in clinical practice.
abstract: The roundtable this month will involve a discussion of two new drugs that have been approved by the Food and Drug Administration for the reduction of low-density lipoprotein cholesterol (LDL-C). The Food and Drug Administration approved the first of these, alirocumab as an "adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease, who require additional lowering of LDL [low-density lipoprotein]-cholesterol." Evolucumab has similar indications plus an indication specifically for treatment of homozygous familial hypercholesterolemia. This sets the stage for their clinical use and in this roundtable, we will discuss with two experts, the implications of these indications for the practicing physician. Dr McKenney and Dr Moriarty have had extensive experience in the conduct of clinical trials that provided the evidence of safety and efficacy of these so called PCSK9 inhibitors.
authors.affiliation: Emory University School of Medicine, Atlanta, GA, USA. Electronic address: wbrow925@bellsouth.net.
authors.forename: W Virgil
authors.initials: WV
authors.lastname: Brown
authors.affiliation: University of Kansas Medical Center, Kansas City, KS, USA.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Moriarty
authors.affiliation: Virginia Commonwealth University and National Clinical Research, Richmond, VA, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: McKenney
mesh_terms: D000328:Adult; D000818:Animals; D006801:Humans; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases / Q000037:antagonists & inhibitors*; D012449:Safety; D012697:Serine Endopeptidases; D015842:Serine Proteinase Inhibitors / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D015842:Serine Proteinase Inhibitors; C472125:PCSK9 protein, human; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases; D012697:Serine Endopeptidases
keywords: Alirocumab; Cholesterol; Evolucumab; LDL-C; Lipoprotein