title: The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study.
abstract: MicroRNAs (miRNAs) play an important role as regulators of tumor suppressors and oncogenes in cancer-related processes. Single nucleotide polymorphisms (SNPs) in miRNAs have been shown to be relevant to various different cancers, including breast cancer (BC). The aim of this study was to estimate the associations between miRNA-related gene polymorphisms (miR-196a2, miR-499, and miR-608) and the risk of BC in a Chinese population. Gene polymorphisms were analyzed in 1143 subjects (controls = 583; BC = 560). The 3 SNPs were genotyped using the Sequenom Mass-ARRAY platform. The associations between the SNP frequencies and BC were assessed by computing odds ratios (ORs) and 95% confidence intervals (95% CIs), as well as by applying Chi-square tests. The miR-196a2 (rs11614913) T allele was associated with a decreased risk of BC based on results from dominant (OR = 0.67, 95% CI = 0.52-0.86), recessive (OR = 0.65, 95% CI = 0.48-0.86), and allele models (OR = 0.73, 95% CI = 0.62-0.86). In contrast, the miR-499 (rs3746444) AG/GG genotypes were associated with an increased risk of BC (OR = 1.45, 95% CI = 1.10-1.91), and miR-608 (rs4919510) was not significantly associated with BC risk. Our study suggested that the polymorphisms of rs11614913 and rs3746444 may be associated with BC risk in Chinese individuals.
authors.affiliation: From the Department of Anesthesiology, Department of Hematology (Z-MD), Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an; Department of Oncology (H-FK, S-QZ, X-BM, SL, MW, Y-JF, KL, X-HL, PX, Z-JD), Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an; Department of Hematology (W-GZ), Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an; Department of Physiology and Pathophysiology (H-BL), Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an, China.
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Dai
authors.forename: Hua-Feng
authors.initials: HF
authors.lastname: Kang
authors.forename: Wang-Gang
authors.initials: WG
authors.lastname: Zhang
authors.forename: Hong-Bao
authors.initials: HB
authors.lastname: Li
authors.forename: Shu-Qun
authors.initials: SQ
authors.lastname: Zhang
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Ma
authors.forename: Shuai
authors.initials: S
authors.lastname: Lin
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Yan-Jing
authors.initials: YJ
authors.lastname: Feng
authors.forename: Kang
authors.initials: K
authors.lastname: Liu
authors.forename: Xing-Han
authors.initials: XH
authors.lastname: Liu
authors.forename: Peng
authors.initials: P
authors.lastname: Xu
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Dai
mesh_terms: D000328:Adult; D044466:Asian People; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C542543:MIRN196 microRNA, human; C548683:MIRN499 microRNA, human; C000591804:MIRN608 microRNA, human; D035683:MicroRNAs