title: Development of monoclonal gammopathy under biotherapy in psoriasis: a French multicenter retrospective study.
abstract: BACKGROUND
  Biotherapies or targeted therapies are fairly new treatments indicated for moderate to severe psoriasis. The side effects appear to be mainly infectious or cancerous. The role of biotherapies in the development of a pre-cancerous condition, monoclonal gammopathy of undetermined significance (MGUS), has recently been debated in the literature.
  
  
  OBJECTIVE
  To evaluate the incidence of MGUS in psoriasis patients treated with biotherapy.
  
  
  METHODS
  This study was a French multicenter retrospective study carried out through the French multicenter study group RESOPSO. Data on the results of serum protein electrophoreses performed before and within at least six months after the start of the biotherapy were collected. Demographic data, medical history, and psoriasis treatment history were specified.
  
  
  RESULTS
  Four hundred and forty three patients were eligible for inclusion. Of these, three presented with monoclonal gammopathy for which the assessment was in favor of MGUS. The average treatment period was 19.7 months. Six patients presented with MGUS prior to the treatment. These patients' immunoglobulin levels remained stable, with an average remission of 24 months. Only psoriatic rheumatism appeared to be statistically linked to MGUS.
  
  
  CONCLUSIONS
  The incidence and frequency of MGUS in psoriasis patients treated with biotherapy do not appear to increase relative to the general population.
authors.affiliation: Dermatology department, Hôpitaux de brabois, Bâtiment des spécialités médicales Philippe Canton, Rue du Morvan, 54511 Vandoeuvre les Nancy, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Liegeon
authors.affiliation: Dermatology department, Hôpital Victor Dupouy, Argenteuil.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mahe
authors.affiliation: Dermatology department, Hôpital de Pontoise, Pontoise.
authors.forename: Edouard
authors.initials: E
authors.lastname: Begon
authors.affiliation: Dermatology department, Hôpitaux de brabois, Bâtiment des spécialités médicales Philippe Canton, Rue du Morvan, 54511 Vandoeuvre les Nancy, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Poreaux
authors.affiliation: Dermatology department, Hôpitaux de brabois, Bâtiment des spécialités médicales Philippe Canton, Rue du Morvan, 54511 Vandoeuvre les Nancy, France.
authors.forename: Annick
authors.initials: A
authors.lastname: Barbaud
authors.affiliation: Dermatology department, CHR Orléans, Orléans.
authors.forename: Eric
authors.initials: E
authors.lastname: Esteve
authors.affiliation: Dermatology department, Hôpital Saint Joseph, Marseille.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Quiles-Tsimaratos
authors.affiliation: Dermatology department, CHU Angers, Angers.
authors.forename: Martine
authors.initials: M
authors.lastname: Avenel-Audran
authors.affiliation: Dermatology department, CHR Metz-Thionville, Thionville.
authors.forename: Amélie
authors.initials: A
authors.lastname: Schoeffler
authors.affiliation: Dermatology department, Hôpital F Quesnay, Mantes la Jolie.
authors.forename: Laure
authors.initials: L
authors.lastname: Mery-Bossard
authors.affiliation: Dermatology department, CHI Saint Germains en Laye, Saint Germain en Laye.
authors.forename: Christine
authors.initials: C
authors.lastname: Pauwels
authors.affiliation: Dermatology department, CHU Montpellier, Montpellier.
authors.forename: Céline
authors.initials: C
authors.lastname: Girard
authors.affiliation: Dermatology department, CH Le Mans, Le Mans.
authors.forename: Hervé
authors.initials: H
authors.lastname: Maillard
authors.affiliation: Dermatology department, Hôpital Pau, Pau.
authors.forename: Dominique
authors.initials: D
authors.lastname: Barthelme
authors.affiliation: Dermatology department, CHU de Nantes.
authors.forename: Claire
authors.initials: C
authors.lastname: Bernier
authors.affiliation: Dermatology department, Hôpital Sud, Amiens.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Chaby
authors.affiliation: Dermatology department, CHU Reims, Reims.
authors.forename: Ziad
authors.initials: Z
authors.lastname: Reguiai
authors.affiliation: Epidemiology and clinical studies department, ESPRI, CHU Nancy.
authors.forename: Phi Linh
authors.initials: PL
authors.lastname: Nguyen-Thi
authors.affiliation: Dermatology department, Hôpital des instructions des armées Begin, Saint Mandé
authors.forename: François
authors.initials: F
authors.lastname: Maccari
authors.affiliation: Dermatology department, Hôpitaux de brabois, Bâtiment des spécialités médicales Philippe Canton, Rue du Morvan, 54511 Vandoeuvre les Nancy, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Schmutz
mesh_terms: D000328:Adult; D000368:Aged; D001685:Biological Factors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000209:etiology*; D011565:Psoriasis / Q000276:immunology / Q000628:therapy*; D012189:Retrospective Studies
chemical_list: D001685:Biological Factors
keywords: biotherapy; monoclonal gammopathy; psoriasis