title: Toward precision medicine in amyotrophic lateral sclerosis.
abstract: Precision medicine is an innovative approach that uses emerging biomedical technologies to deliver optimally targeted and timed interventions, customized to the molecular drivers of an individual's disease. This approach is only just beginning to be considered for treating amyotrophic lateral sclerosis (ALS). The clinical and biological complexities of ALS have hindered development of effective therapeutic strategies. In this review we consider applying the key elements of precision medicine to ALS: phenotypic classification, comprehensive risk assessment, presymptomatic period detection, potential molecular pathways, disease model development, biomarker discovery and molecularly tailored interventions. Together, these would embody a precision medicine approach, which may provide strategies for optimal targeting and timing of efforts to prevent, stop or slow progression of ALS.
authors.affiliation: Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors.forename: Zhang-Yu
authors.initials: ZY
authors.lastname: Zou
authors.affiliation: Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Liu
authors.affiliation: Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: Che
authors.affiliation: Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors.forename: Hua-Pin
authors.initials: HP
authors.lastname: Huang
keywords: Amyotrophic lateral sclerosis (ALS); customized therapies; precision medicine