title: Recoding a cocaine-place memory engram to a neutral engram in the hippocampus.
abstract: The hippocampus provides the brain's memory system with a subset of neurons holding a map-like representation of each environment experienced. We found in mice that optogenetic silencing those neurons active in an environment unmasked a subset of quiet neurons, enabling the emergence of an alternative map. When applied in a cocaine-paired environment, this intervention neutralized an otherwise long-lasting drug-place preference, showing that recoding a spatial memory engram can alleviate associated maladaptive behavior.
authors.affiliation: Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Trouche
authors.affiliation: Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
authors.forename: Pavel V
authors.initials: PV
authors.lastname: Perestenko
authors.affiliation: Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
authors.forename: Gido M
authors.initials: GM
authors.lastname: van de Ven
authors.affiliation: Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
authors.forename: Claire T
authors.initials: CT
authors.lastname: Bratley
authors.affiliation: Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
authors.forename: Colin G
authors.identifier: http://orcid.org/0000-0001-8266-9266
authors.initials: CG
authors.lastname: McNamara
authors.affiliation: Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
authors.forename: Natalia
authors.initials: N
authors.lastname: Campo-Urriza
authors.affiliation: Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
authors.forename: S Lucas
authors.initials: SL
authors.lastname: Black
authors.affiliation: Department of Neuroscience, School of Medicine, Tufts University, Boston, Massachusetts, USA.
authors.forename: Leon G
authors.initials: LG
authors.lastname: Reijmers
authors.affiliation: Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
authors.forename: David
authors.initials: D
authors.lastname: Dupret
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D003042:Cocaine / Q000008:administration & dosage*; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D062308:Optogenetics / Q000379:methods*
chemical_list: D003042:Cocaine