title: Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report.
abstract: The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi-step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array-comparative genomic hybridization (a-CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a-CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi-step carcinogenic process in the lung.
authors.affiliation: Cytogenetic and Medical Genetic Laboratory, Operative Unit of Clinical Investigations, Humanitas Clinical and Research Center, Milan I-20089, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Bettio
authors.affiliation: Cytogenetic and Medical Genetic Laboratory, Operative Unit of Clinical Investigations, Humanitas Clinical and Research Center, Milan I-20089, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Venci
authors.affiliation: Cytogenetic and Medical Genetic Laboratory, Operative Unit of Clinical Investigations, Humanitas Clinical and Research Center, Milan I-20089, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Achille
authors.affiliation: Department of Thoracic Surgery, Humanitas Clinical and Research Center, Milan I-20089, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Alloisio
authors.affiliation: Department of Oncology and Hematology, Humanitas Cancer Center, Humanitas Clinical and Research Center, Milan I-20089, Italy.
authors.forename: Armando
authors.initials: A
authors.lastname: Santoro
keywords: adenomatous hyperplasia; array-comparative genomic hybridization; chromosome abnormalities; lung cancer; multi-step progression