title: Innovative hybrid vs polymeric nanocapsules: The influence of the cationic lipid coating on the "4S".
abstract: Polymeric and hybrid aqueous-core nanocapsules were prepared using a low energy organic-solvent free procedure as innovative nanodevices for the ophthalmic delivery of melatonin. In order to evaluate how different cationic lipids could affect the main properties of the nanodevices, we focused our attention on mean particles size, surface charge, shape and stability (the "4S"). The results of our study confirmed the hypothesis that the coating material differently affects the overall nanoparticles properties, above all in terms of morphology: in particular, the cationic lipid dimethyldioctadecylammonium bromide allows the formation of very stable well-defined nanocapsules with non-spherical shape with sustained and prolonged drug release, thus representing a great advantage in ophthalmic application.
authors.affiliation: Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; NANO-i-Research Centre On Ocular Nanotechnology-University of Catania, Catania, Italy. Electronic address: ccarbone@unict.it.
authors.forename: C
authors.initials: C
authors.lastname: Carbone
authors.affiliation: Physics Applied to Material Science Laboratory, Department of Environmental and Biological Sciences and Technologies, University of Salento, via Provinciale Lecce-Monteroni, Lecce, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Manno
authors.affiliation: Physics Applied to Material Science Laboratory, Department of Environmental and Biological Sciences and Technologies, University of Salento, via Provinciale Lecce-Monteroni, Lecce, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Serra
authors.affiliation: Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; NANO-i-Research Centre On Ocular Nanotechnology-University of Catania, Catania, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Musumeci
authors.affiliation: Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; NANO-i-Research Centre On Ocular Nanotechnology-University of Catania, Catania, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Pepe
authors.affiliation: Formulaction SA 10, Impasse Borde Basse, 31240 L'Union, France.
authors.forename: C
authors.initials: C
authors.lastname: Tisserand
authors.affiliation: Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; NANO-i-Research Centre On Ocular Nanotechnology-University of Catania, Catania, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Puglisi
mesh_terms: D060433:Administration, Ophthalmic; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D002412:Cations / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D020285:Cryoelectron Microscopy; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004355:Drug Stability; D008055:Lipids / Q000737:chemistry*; D008550:Melatonin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D046529:Microscopy, Electron, Transmission; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D013499:Surface Properties
chemical_list: D000975:Antioxidants; D002412:Cations; D020099:Coated Materials, Biocompatible; D008055:Lipids; D053769:Nanocapsules; D011108:Polymers; D008550:Melatonin
keywords: CTAB; DDAB; Ocular; PLA; Shape; Size; Stability; Surface charge; Sustained release