title: Analysis ofXRCC2andXRCC3gene polymorphisms in pancreatic cancer.
abstract: The double-strand break DNA repair pathway, includingXRCC2andXRCC3genes, is implicated in maintaining genomic stability and therefore could affect the pancreatic cancer risk. The aim of the present study was to evaluate the clinical significance of theXRCC2andXRCC3gene polymorphisms in patients with pancreatic cancer. The present study included 203 patients: 101 with pancreatic cancer and 102 healthy controls. The Arg188HisXRCC2and the Thr241MetXRCC3gene polymorphisms have been studied in DNA isolated from blood samples. The associations of the analysed genotypes and clinical data at diagnosis have been evaluated. The frequencies of the genotypes of the Arg188HisXRCC2and Thr241MetXRCC3polymorphisms did not differ significantly between patients and controls. The study did not identify a correlation between theXRCC2andXRCC3genes polymorphisms and tumor size or localisation. Analysed polymorphisms were also not associated with the gender and age of the patient, or the presence of regional or distant metastases. In conclusion, the present study did not suggest an association between the Arg188HisXRCC2and the Thr241MetXRCC3polymorphisms and the clinical data of patients with pancreatic cancer.
authors.affiliation: Department of Digestive Tract Diseases, Medical University of Łódź, 90-153 Łódź, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Talar-Wojnarowska
authors.affiliation: Department of Digestive Tract Diseases, Medical University of Łódź, 90-153 Łódź, Poland.
authors.forename: Anita
authors.initials: A
authors.lastname: Gąsiorowska
authors.affiliation: Department of Digestive Tract Surgery, Silesian Medical University, 40-055 Katowice, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Olakowski
authors.affiliation: Department of Digestive Tract Surgery, Silesian Medical University, 40-055 Katowice, Poland.
authors.forename: Daria
authors.initials: D
authors.lastname: Dranka-Bojarowska
authors.affiliation: Department of Digestive Tract Surgery, Silesian Medical University, 40-055 Katowice, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Lampe
authors.affiliation: Laboratory of Molecular Genetics, Institute of Polish Mother's Memorial Hospital, 93-338 Łódź, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Smolarz
authors.affiliation: Department of Digestive Tract Diseases, Medical University of Łódź, 90-153 Łódź, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Małecka-Panas
keywords: DNA repair genes; XRCC2; XRCC3; pancreatic cancer; polymorphism