title: ACAID as a potential therapeutic approach to modulate inflammation in neurodegenerative diseases.
abstract: The progressive loss of neurons and inflammation characterizes neurodegenerative diseases. Although the etiology, progression and outcome of different neurodegenerative diseases are varied, they share chronic inflammation maintained largely by central nervous system (CNS)-derived antigens recognized by T cells. Inflammation can be beneficial by recruiting immune cells to kill pathogens or to clear cell debris resulting from the primary insult. However, chronic inflammation exacerbates and perpetuates tissue damage. An increasing number of therapies that attempt to modulate neuroinflammation have been developed. However, so far none has succeeded in decreasing the secondary damage associated with chronic inflammation. A potential strategy to modulate the immune system is related to the induction of tolerance to CNS antigens. In this line, it is our hypothesis that this could be accomplished by using anterior chamber associated immune deviation (ACAID) as a strategy. Thus, we review current knowledge regarding some neurodegenerative diseases and the associated immune response that causes inflammation. In addition, we discuss further our hypothesis of the possible usefulness of ACAID as a therapeutic strategy to ameliorate damage to the CNS.
authors.affiliation: Facultad de Ciencias de la Salud, Universidad Anáhuac México Norte, Av. Universidad Anáhuac 46, Huixquilucan, México, D. F. 527896, Mexico.
authors.forename: D
authors.initials: D
authors.lastname: Toscano-Tejeida
authors.affiliation: Facultad de Ciencias de la Salud, Universidad Anáhuac México Norte, Av. Universidad Anáhuac 46, Huixquilucan, México, D. F. 527896, Mexico. Electronic address: iantonio65@yahoo.com.
authors.forename: A
authors.initials: A
authors.lastname: Ibarra
authors.affiliation: Laboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Insurgentes Sur 3700C, Col. Insurgentes Cuicuilco, Del. Coyoacán, México, D. F. 04530, Mexico.
authors.forename: B V
authors.initials: BV
authors.lastname: Phillips-Farfán
authors.affiliation: Laboratorio de Ecofisiología Animal, Departamento de Zoología, Instituto de Investigaciones sobre los Recursos Naturales, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán 58337, Mexico.
authors.forename: A L
authors.initials: AL
authors.lastname: Fuentes-Farías
authors.affiliation: Laboratorio de Ecofisiología Animal, Departamento de Zoología, Instituto de Investigaciones sobre los Recursos Naturales, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán 58337, Mexico. Electronic address: oazul74@yahoo.com.mx.
authors.forename: E
authors.initials: E
authors.lastname: Meléndez-Herrera
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology; D000690:Amyotrophic Lateral Sclerosis / Q000276:immunology; D000867:Anterior Chamber / Q000276:immunology*; D000941:Antigens / Q000276:immunology; D002490:Central Nervous System / Q000276:immunology; D002493:Central Nervous System Diseases / Q000276:immunology; D005123:Eye / Q000276:immunology; D006801:Humans; D007107:Immune System; D007108:Immune Tolerance; D007249:Inflammation; D009103:Multiple Sclerosis / Q000276:immunology; D019636:Neurodegenerative Diseases / Q000276:immunology* / Q000628:therapy; D009474:Neurons / Q000378:metabolism; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
chemical_list: D000941:Antigens