title: L-Rhamnose isomerase and its use for biotechnological production of rare sugars.
abstract: L-Rhamnose isomerase (L-RI, EC 5.3.1.14), catalyzing the isomerization between L-rhamnose and L-rhamnulose, plays an important role in microbial L-rhamnose metabolism and thus occurs in a wide range of microorganisms. It attracts more and more attention because of its broad substrate specificity and its great potential in enzymatic production of various rare sugars. In this article, the enzymatic properties of various reported L-RIs were compared in detail, and their applications in the production of L-rhamnulose and various rare sugars including D-allose, D-gulose, L-lyxose, L-mannose, L-talose, and L-galactose were also reviewed.
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
authors.forename: Wenli
authors.initials: W
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China. wmmu@jiangnan.edu.cn.|Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, 214122, China. wmmu@jiangnan.edu.cn.
authors.forename: Wanmeng
authors.initials: W
authors.lastname: Mu
mesh_terms: D019747:Aldose-Ketose Isomerases / Q000235:genetics / Q000378:metabolism*; D001412:Bacillus subtilis / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001709:Biotechnology; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D005690:Galactose / Q000096:biosynthesis; D015870:Gene Expression; D005947:Glucose / Q000096:biosynthesis; D006601:Hexoses / Q000096:biosynthesis; D007783:Lactones / Q000378:metabolism; D008358:Mannose / Q000096:biosynthesis; D010429:Pentoses / Q000096:biosynthesis; D012210:Rhamnose / Q000378:metabolism*; D013237:Stereoisomerism; D020124:Thermotoga maritima / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D006601:Hexoses; C510913:L-talo-gamma-lactone; D007783:Lactones; D010429:Pentoses; C057406:gulose; C002055:allose; C043333:lyxose; D019747:Aldose-Ketose Isomerases; C062878:L-rhamnose isomerase; D005947:Glucose; D008358:Mannose; D012210:Rhamnose; D005690:Galactose
keywords: D-Allose; L-Rhamnose isomerase; Monosaccharide; Rare sugar; Substrate specificity