title: Prophylactic neck dissection for low-risk differentiated thyroid cancers: Risk-benefit analysis.
abstract: The benefit of neck dissection is the subject of debate in differentiated thyroid cancer (DTC). We analyze the risk-benefit of neck dissection for low-risk DTC without detectable lymph nodes.
  
  
  
  We conducted a retrospective study from 1983 to 2003; which included 295 patients without detectable lymph nodes who were treated by thyroidectomy with (C+) or without (C-) neck dissection. All patients had iodine131 therapy. We compared the frequency of remission, disease progression, and permanent complications between groups.
  
  
  
  Two hundred twelve patients comprised the C+ group, and 83 patients the C- group. Respectively for C+ versus C-, remission rates were 92% versus 89.2% (p = .40), and progressive disease observed was 3.3% versus 7.2% (p = .10). Permanent hypoparathyroidism occurred in 15.1% in C+ versus 3.6% in C- (p = .006).
  
  
  
  The risk-benefit analysis of neck dissection in patients with low-risk DTC shows no benefit in terms of complete remission or occurrence of progression. However, risk of complications seems to be higher in patients with neck dissection. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1091-1096, 2016.
authors.affiliation: Thyroïde Marne-Ardennes Register, CLCC Institut Jean Godinot, Reims, France.|Otolaryngology Department, Centre Hospitalier Robert Debré, Reims, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Dubernard
authors.affiliation: Thyroïde Marne-Ardennes Register, CLCC Institut Jean Godinot, Reims, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Dabakuyo
authors.affiliation: Thyroïde Marne-Ardennes Register, CLCC Institut Jean Godinot, Reims, France.
authors.forename: Samiratou
authors.initials: S
authors.lastname: Ouedraogo
authors.affiliation: General Surgery Department, CLCC Institut Jean Godinot, Reims, France.
authors.forename: Koceila
authors.initials: K
authors.lastname: Amroun
authors.affiliation: General Surgery Department, CLCC Institut Jean Godinot, Reims, France.
authors.forename: David
authors.initials: D
authors.lastname: Kere
authors.affiliation: Otolaryngology Department, Polyclinique de Courlancy, Reims, France.
authors.forename: Talal
authors.initials: T
authors.lastname: Nasser
authors.affiliation: General Surgery Department, Centre Hospitalier Robert Debré, Reims, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Deguelte
authors.affiliation: Thyroïde Marne-Ardennes Register, CLCC Institut Jean Godinot, Reims, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Pochart
authors.affiliation: Otolaryngology Department, Centre Hospitalier Robert Debré, Reims, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Merol
authors.affiliation: Otolaryngology Department, Centre Hospitalier Robert Debré, Reims, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Makeieff
authors.affiliation: Otolaryngology Department, Centre Hospitalier Robert Debré, Reims, France.
authors.forename: André
authors.initials: A
authors.lastname: Chays
authors.affiliation: Thyroïde Marne-Ardennes Register, CLCC Institut Jean Godinot, Reims, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Schvartz
mesh_terms: D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000473:pathology* / Q000601:surgery*; D016009:Chi-Square Distribution; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000009:adverse effects / Q000379:methods*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011322:Primary Prevention / Q000379:methods; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery*; D013965:Thyroidectomy / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome
keywords: cancers; dissection; low-risk; prophylactic; thyroid