title: Liver Transplantation for Non-B and Non-C Hepatocellular Carcinoma.
abstract: OBJECTIVE
  Few studies have characterized the outcomes and clinical features of patients who undergo liver transplantation (LT) for hepatocellular carcinoma (HCC) due to non-viral causes.
  
  
  METHODS
  We retrospectively analyzed 188 patients with HCC who underwent LT between February 1999 and October 2010. The clinicopathological factors and overall survival rates as well as recurrence rates of 17 patients with non-hepatitis B virus (HBV) and non-hepatitis C virus (HCV) infection (NBNC group) and 171 patients with HBV or HCV infection (HBV/ HCV group) were compared.
  
  
  RESULTS
  HCC patients in the NBNC group were significantly younger at time of transplant, had higher serum des-gamma-carboxy prothrombin levels, and had larger pathological tumor size when compared with patients in the HBV/ HCV group. Overall survival rates were lower, and recurrence rates were higher in the NBNC group than in the HBV/HCV group. However, both these rates were significantly improved in NBNC patients who met our expanded selection criteria when compared with those that did not meet these criteria.
  
  
  CONCLUSIONS
  The patients with NBNC HCC had more advanced and biologically aggressive tumors with inferior outcomes when compared with those with HBV/HCV. However, use of appropriate selection criteria for LT yields improved outcomes even in this subgroup of patients.
authors.forename: Toshimi
authors.initials: T
authors.lastname: Kaido
authors.forename: Akira
authors.initials: A
authors.lastname: Mori
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ogura
authors.forename: Koichiro
authors.initials: K
authors.lastname: Hata
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yoshizawa
authors.forename: Taku
authors.initials: T
authors.lastname: lida
authors.forename: Shintaro
authors.initials: S
authors.lastname: Yagi
authors.forename: Shinji
authors.initials: S
authors.lastname: Uemoto
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000150:complications / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018579:Patient Selection; D011498:Protein Precursors / Q000097:blood; D011516:Prothrombin; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D047368:Tumor Burden; D055815:Young Adult
chemical_list: D015415:Biomarkers; D011498:Protein Precursors; C008208:acarboxyprothrombin; D011516:Prothrombin