title: BREADTH SPREADING OF VIRAL HEPATITIS MARKERS IN THE RISK GROUPS IN THE REPUBLIC OF SAKHA (YAKUTIA).
abstract: BACKGROUND
  Republic of Sakha (Yakutia) is a hyperendemic region of Russian Federation for spreading of parenteral viral hepatitis B, C and D. In risk groups of these diseases are firstly medical personnel, who contacting with infection carriers including latent infections family and members of families of chronic viral hepatitis carriers.
  
  
  OBJECTIVE
  To reveal the breadth of spreading of viral hepatitis markers in the risk groups.
  
  
  METHODS
  The level of HBV- and HC- infection were determined in medical staff of large multi specialty hospital and family members of people with viral hepatitis B and C. Epidemiological, clinical, serological and molecular biology methods of viral hepatitis diagnostics were applied in this study.
  
  
  RESULTS
  Results of this study showed that the staff at surgery and hematology departments and all nursing staff belong to the high-risk of HBV-infection groups. Therefore, they are a priority for active immunization. Attention is paid on the fact that infectivity of medical staff is not equally distributed in dependence on type of department and position of medical staff. Rate HBV-marker detecting in "family hearths" was dependent on degree of interrelationship with infection source. According received information, in families of patientwith chronic hepatitis B spreading of infection was higher (77.6%) then in families of patients with acute hepatitis B (39.7%). At primary examination of families an anti-HCV was detected in 9.3 ± 1.8% cases, i.e. the spreading of HCV was at low-activity.
  
  
  CONCLUSIONS
  Results of our study on spreading of hepatitis B and C in Yakutia showed the high rate of appearance of HCV and HBV markers in the risk groups.
authors.forename: S S
authors.initials: SS
authors.lastname: Sleptsova
authors.forename: V K
authors.initials: VK
authors.lastname: Semenova
authors.forename: P S
authors.initials: PS
authors.lastname: Dyatchkovskaya
authors.forename: S G
authors.initials: SG
authors.lastname: Nikitina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001110:Arctic Regions / Q000453:epidemiology / Q000208:ethnology; D015415:Biomarkers / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D018562:Disease Transmission, Infectious / Q000706:statistics & numerical data*; D005190:Family; D005260:Female; D006282:Health Personnel / Q000706:statistics & numerical data*; D006505:Hepatitis / Q000175:diagnosis* / Q000453:epidemiology* / Q000208:ethnology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D044382:Population Groups; D018570:Risk Assessment; D012426:Russia / Q000453:epidemiology / Q000208:ethnology; D055815:Young Adult
chemical_list: D015415:Biomarkers