title: Pathobiology of Ischemic Heart Disease: Past, Present and Future.
abstract: This review provides a perspective on knowledge of ischemic heart disease (IHD) obtained from the contemporary era of research which began in the 1960s and has continued to the present day. Important discoveries have been made by basic and translational scientists and clinicians. Pathologists have contributed significantly to insights obtained from experimental studies and clinicopathological studies in humans. The review also provides a perspective for future directions in research in IHD aimed at increasing basic knowledge and developing additional therapeutic options for patients with IHD.
authors.affiliation: Department of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas. Electronic address: l.maximilian.buja@uth.tmc.edu.
authors.forename: L Maximilian
authors.initials: LM
authors.lastname: Buja
authors.affiliation: Department of Pathology, Louisiana State Health Science Center, New Orleans, Louisiana.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Vander Heide
mesh_terms: D002309:Cardiology / Q000379:methods / Q000639:trends*; D006801:Humans; D017202:Myocardial Ischemia
keywords: Hibernation; Mitochondria; Myocardial infarction; Myocardial ischemia; Postconditioning; Preconditioning; Stunning