title: Recombinant Patterns of Nine Novel HIV-1 Recombinant Strains Identified in Hebei Province, China.
abstract: We found cluster 1 and cluster 2 that were identified as two potential circulating recombinant forms (CRFs) by analyzing the recombinant breakpoints and phylogenetic tree. Three sequences composed of CRF01_AE, subtype C, and potential subtype B (N/A) in cluster 1 had nearly identical recombinant breakpoints, and four sequences composed of CRF01_AE and subtype B in cluster 2 possessed identical breakpoints. Demographic characteristics indicated that there were no epidemiological linkages among three subjects in cluster 1 and four subjects in cluster 2, respectively. Likewise, two unique recombinant forms (URFs) were found in this study: one URF was composed of subtype C and subtype B, and subtype B was inserted into a backbone of subtype C; another URF was composed of subtype C, subtype B, CRF01_AE, and subtype A2. It was inferred that the potential novel CRFs and URFs have spread into general populations, suggesting that the series research of novel recombinant strains will be a priority for our researches in the future.
authors.affiliation: 1 Hebei Provincial Center for Disease Control and Prevention , Shjiazhuang, People's Republic of China .
authors.forename: Xinli
authors.initials: X
authors.lastname: Lu
authors.affiliation: 2 Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing, People's Republic of China .
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Liu
authors.affiliation: 1 Hebei Provincial Center for Disease Control and Prevention , Shjiazhuang, People's Republic of China .
authors.forename: Hongru
authors.initials: H
authors.lastname: Zhao
authors.affiliation: 1 Hebei Provincial Center for Disease Control and Prevention , Shjiazhuang, People's Republic of China .
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 1 Hebei Provincial Center for Disease Control and Prevention , Shjiazhuang, People's Republic of China .
authors.forename: Cuiying
authors.initials: C
authors.lastname: Zhao
authors.affiliation: 1 Hebei Provincial Center for Disease Control and Prevention , Shjiazhuang, People's Republic of China .
authors.forename: Suliang
authors.initials: S
authors.lastname: Chen
authors.affiliation: 2 Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing, People's Republic of China .
authors.forename: Jingyun
authors.initials: J
authors.lastname: Li
authors.affiliation: 1 Hebei Provincial Center for Disease Control and Prevention , Shjiazhuang, People's Republic of China .
authors.forename: Ze
authors.initials: Z
authors.lastname: Cui
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D016679:Genome, Viral / Q000235:genetics*; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D015497:HIV-1 / Q000145:classification* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D010802:Phylogeny; D012367:RNA, Viral / Q000097:blood* / Q000235:genetics; D011995:Recombination, Genetic; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000235:genetics; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D012367:RNA, Viral; D054301:gag Gene Products, Human Immunodeficiency Virus; D054302:pol Gene Products, Human Immunodeficiency Virus