title: [Expression and prognostic value of MTDH, Bcl-2 and E-cadherin in sinonasal malignant mucosal melanoma].
abstract: OBJECTIVE
  To study the expression and predictive value of MTDH, Bcl-2 and E-cadherin in sinonasal malignant mucosal melanoma (SNM).
  
  
  METHODS
  Seventy-four formalin-fixed paraffin-embedded SNM specimens were subjected to immunohistochemical staining of MTDH, Bcl-2 and E-cadherin. Correlation between staining results and disease outcome was analyzed.SPSS 19.0 software was used to analyze the data.
  
  
  RESULTS
  Positive staining of MTDH, Bcl-2 and E-cadherin was observed in 56/74 (75.7%), 18/74 (24.3%) and 21/74 (28.4%) cases, respectively. MTDH positive patients had higher metastatic rate than MTDH negative patients (67.9% vs. 33.3%, P=0.009, OR=2.037, 95% CI: 1.034-4.016). Negative Bcl-2 was correlated with worse overall survival time (HR=2.023, P=0.025). Expression of E-cadherin was adversely associated with expression of MTDH (r=-0.315, P=0.006).
  
  
  CONCLUSIONS
  High MTDH expression and low Bcl-2 expression suggest poor prognosis of SNM, while the predictive value of E-cadherin needs further study.
authors.affiliation: Department of Pathology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.
authors.forename: Bingqing
authors.initials: B
authors.lastname: Zou
authors.affiliation: Department of Pathology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China; Email: wangshuyi@eent.shmu.edu.cn.
authors.forename: Shuyi
authors.initials: S
authors.lastname: Wang
mesh_terms: D015703:Antigens, CD; D015820:Cadherins / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008565:Membrane Proteins; D009362:Neoplasm Metastasis; D009669:Nose Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D016601:RNA-Binding Proteins; D015996:Survival Rate
chemical_list: D015703:Antigens, CD; C000595707:BCL2 protein, human; C513384:CDH1 protein, human; D015820:Cadherins; D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016601:RNA-Binding Proteins