title: Cancer and life-history traits: lessons from host-parasite interactions.
abstract: Despite important differences between infectious diseases and cancers, tumour development (neoplasia) can nonetheless be closely compared to infectious disease because of the similarity of their effects on the body. On this basis, we predict that many of the life-history (LH) responses observed in the context of host-parasite interactions should also be relevant in the context of cancer. Parasites are thought to affect LH traits of their hosts because of strong selective pressures like direct and indirect mortality effects favouring, for example, early maturation and reproduction. Cancer can similarly also affect LH traits by imposing direct costs and/or indirectly by triggering plastic adjustments and evolutionary responses. Here, we discuss how and why a LH focus is a potentially productive but under-exploited research direction for cancer research, by focusing our attention on similarities between infectious disease and cancer with respect to their effects on LH traits and their evolution. We raise the possibility that LH adjustments can occur in response to cancer via maternal/paternal effects and that these changes can be heritable to (adaptively) modify the LH traits of their offspring. We conclude that LH adjustments can potentially influence the transgenerational persistence of inherited oncogenic mutations in populations.
authors.affiliation: School of Life and Environmental Sciences,Centre for Integrative Ecology,Deakin University,Geelong,VIC, 3216,Australia.
authors.forename: Beata
authors.initials: B
authors.lastname: Ujvari
authors.affiliation: School of Life and Environmental Sciences,Centre for Integrative Ecology,Deakin University,Geelong,VIC, 3216,Australia.
authors.forename: Christa
authors.initials: C
authors.lastname: Beckmann
authors.affiliation: School of Life and Environmental Sciences,Centre for Integrative Ecology,Deakin University,Geelong,VIC, 3216,Australia.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Biro
authors.affiliation: CREEC/MIVEGEC,UMR IRD/CNRS/UM 5290,911 Avenue Agropolis,BP 64501,34394 Montpellier Cedex 5,France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Arnal
authors.affiliation: UMR CNRS 8198,Unité Evolution, Ecologie et Paléontologie,Université de Lille1,France.
authors.forename: Aurelie
authors.initials: A
authors.lastname: Tasiemski
authors.affiliation: UMR CNRS 8198,Unité Evolution, Ecologie et Paléontologie,Université de Lille1,France.
authors.forename: Francois
authors.initials: F
authors.lastname: Massol
authors.affiliation: Laboratoire Protéomique,Réponse Inflammatoire et Spectrométrie de Masse (PRISM) INSERM U1192 - Université Lille,1-FR 3688,CNRS,France.
authors.forename: Michel
authors.initials: M
authors.lastname: Salzet
authors.affiliation: Evolution, Génomes, Comportement & Ecologie,CNRS, IRD,Univ.Paris-Sud, Université Paris Saclay,91198 Gif-sur-Yvette.
authors.forename: Frederic
authors.initials: F
authors.lastname: Mery
authors.affiliation: UMR CNRS 8198,Unité Evolution, Ecologie et Paléontologie,Université de Lille1,France.
authors.forename: Celine
authors.initials: C
authors.lastname: Boidin-Wichlacz
authors.affiliation: CREEC/MIVEGEC,UMR IRD/CNRS/UM 5290,911 Avenue Agropolis,BP 64501,34394 Montpellier Cedex 5,France.
authors.forename: Dorothee
authors.initials: D
authors.lastname: Misse
authors.affiliation: CREEC/MIVEGEC,UMR IRD/CNRS/UM 5290,911 Avenue Agropolis,BP 64501,34394 Montpellier Cedex 5,France.
authors.forename: Francois
authors.initials: F
authors.lastname: Renaud
authors.affiliation: Centre de Recherche de la Tour du Valat,le Sambuc,13200 Arles,France.
authors.forename: Marion
authors.initials: M
authors.lastname: Vittecoq
authors.affiliation: CREEC/MIVEGEC,UMR IRD/CNRS/UM 5290,911 Avenue Agropolis,BP 64501,34394 Montpellier Cedex 5,France.
authors.forename: Tazzio
authors.initials: T
authors.lastname: Tissot
authors.affiliation: CREEC/MIVEGEC,UMR IRD/CNRS/UM 5290,911 Avenue Agropolis,BP 64501,34394 Montpellier Cedex 5,France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Roche
authors.affiliation: Department of Zoology,University of Otago,PO BOX 56,New-Zealand.
authors.forename: Robert
authors.initials: R
authors.lastname: Poulin
authors.affiliation: CREEC/MIVEGEC,UMR IRD/CNRS/UM 5290,911 Avenue Agropolis,BP 64501,34394 Montpellier Cedex 5,France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Thomas
mesh_terms: D000818:Animals; D005075:Biological Evolution; D006790:Host-Parasite Interactions / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D010272:Parasitic Diseases / Q000209:etiology* / Q000469:parasitology / Q000503:physiopathology
keywords: Cancer; evolutionary ecology; life-history traits; parasites; plasticity