title: Prognostic value of caveolin-1 in genitourinary cancer: a meta-analysis.
abstract: We aimed to obtain the most comprehensive picture to date of the prognostic value of caveolin-1 (Cav-1) in genitourinary carcinoma by meta-analyzing all eligible studies in PubMed and EMBASE. Data on patient clinical characteristics, cancer-specific survival (CSS) and recurrence-free survival (RFS) were extracted. The meta-analysis included 6 articles on prostate cancer, 5 on renal cancer, 1 on bladder cancer and 1 on transition cell carcinoma of the upper urinary tract. Two studies examining the association of ELISA-measured Cav-1 levels in serum with RFS in 621 patients with prostate cancer gave a combined hazard ratio (HR) of 1.25 (95% CI 0.36 to 4.36). The other 4 studies on prostate cancer examined the association of immunohistochemically determined Cav-1 levels in cancerous tissue with RFS and gave a combined HR of 1.83 (95% CI 1.36 to 2.47). Three studies on renal cancer examining the association of Cav-1 levels with CSS gave a multivariate HR of 1.98 (95% CI 1.35 to 2.90). The single studies on bladder carcinoma and upper urinary tract carcinoma gave, respectively, a multivariate HR of 2.28 (95% CI 1.09 to 4.74) for the relationship of Cav-1 levels to DFS, and a multivariate HR of 5.08 (95% CI 1.799 to 14.342) for the relationship of Cav-1 levels to CSS. This meta-analysis of available evidence suggests that elevated Cav-1 levels in serum can predict poor survival in patients with genitourinary cancer, which may help identify high-risk patients earlier and guide clinical decision-making.
authors.affiliation: Department of Urology, West China Hospital, Sichuan University Guoxuexiang 37, Chengdu 610041, Sichuan, China.
authors.forename: Jia-Ming
authors.initials: JM
authors.lastname: Liu
authors.affiliation: Department of Urology, West China Hospital, Sichuan University Guoxuexiang 37, Chengdu 610041, Sichuan, China.
authors.forename: Si-Hang
authors.initials: SH
authors.lastname: Cheng
authors.affiliation: West China School of Medicine, Sichuan University Guoxuexiang 37, Chengdu 610041, Sichuan, China.
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Liu
authors.affiliation: West China School of Medicine, Sichuan University Guoxuexiang 37, Chengdu 610041, Sichuan, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Xia
authors.affiliation: West China School of Medicine, Sichuan University Guoxuexiang 37, Chengdu 610041, Sichuan, China.
authors.forename: Wei-Wen
authors.initials: WW
authors.lastname: Wang
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu 610041, China.
authors.forename: Xue-Lei
authors.initials: XL
authors.lastname: Ma
keywords: Genitourinary cancer; caveolin-1; meta-analysis; prognosis