title: E2F1 and NF-κB: Key Mediators of Inflammation-associated Cancers and Potential Therapeutic Targets.
abstract: Inflammation is the fundamental protective response; however disordered immuno-response can cause chronic human disease, including cancer. Inflammatory cells and mediators are essential to the tumor microenvironment and dissection of this complex molecular and cellular milieu may elucidate a connection between cancer and inflammation and help to identify potential novel therapeutic targets. Thus, focusing on transcription factor NF-κB and E2F1 in inflammation-associated cancer is urgent. NF-κB activation is prevalent in carcinomas, mainly driven by inflammatory cytokines in the tumor microenvironment. E2F1 is also involved in regulating immune responses. Understanding the crosstalk between the two pathways may contribute to the development of novel anti-cancer drugs.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Dingjiaqiao 87, Nanjing, 210009, P.R. China. 101011816@seu.edu.cn.
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Molecular Cell Biology and Toxicology, School of Public Health, Nanjing Medical University, 101Longmian Avenue, Nanjing 211166, People's Republic of China. jwzhou@njmu.edu.cn.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D050687:E2F1 Transcription Factor / Q000378:metabolism*; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000150:complications / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000379:methods*; D016328:NF-kappa B / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000209:etiology*; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents; D050687:E2F1 Transcription Factor; C493753:E2F1 protein, human; D018836:Inflammation Mediators; D016328:NF-kappa B