title: Efficient MoS2 Exfoliation by Cross-β-Amyloid Nanotubes for Multistimuli-Responsive and Biodegradable Aqueous Dispersions.
abstract: Herein, we report the efficient exfoliation of MoS2 in aqueous medium by short cationic peptide nanotubes featuring the nucleating core (17) LVFFA(21) of β-amyloid (Aβ 1-42), a sequence associated with Alzheimer's disease. The role of morphology, length, and nature of the amyloid surface on exfoliation/dispersions of MoS2 were investigated through specific mutations of the amyloid sequences. Notably, owing to the properties of both the constituents, self-assembled soft nanostructures and MoS2 , the hybrid dispersions responded reversibly to various stimuli, including temperature, pH, and light. Addition of a protease resulted in loss of the dispersions, which are otherwise stable for months at ambient conditions. The design flexibility of the peptide sequences, along with the stimuli-responsiveness and biodegradability, can complement the applications of MoS2 in diverse fields.
authors.affiliation: Institute of Nano Science and Technology, Phase 10, Mohali, 160062, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Kapil
authors.affiliation: Institute of Nano Science and Technology, Phase 10, Mohali, 160062, India.
authors.forename: Ashmeet
authors.initials: A
authors.lastname: Singh
authors.affiliation: Institute of Nano Science and Technology, Phase 10, Mohali, 160062, India.
authors.forename: Manish
authors.initials: M
authors.lastname: Singh
authors.affiliation: Indian Institute of Science Education and Research (IISER) Tirupati, Andhra Pradesh, 517507, India. dasd@iisertirupati.ac.in, ddas.chem@gmail.com.
authors.forename: Dibyendu
authors.identifier: 0000-0001-6597-8454
authors.initials: D
authors.lastname: Das
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D002412:Cations / Q000737:chemistry; D004220:Disulfides / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008027:Light; D008982:Molybdenum / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010446:Peptide Fragments / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D002412:Cations; D004220:Disulfides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D014867:Water; D008982:Molybdenum; C082964:molybdenum disulfide
keywords: 2D materials; amyloid nanostructures; liquid exfoliation; molybdenum; supramolecular chemistry