title: Megastigmane Glycosides from the Leaves of Tripterygium wilfordii.
abstract: Two new megastigmane glycosides, named wilfordonisides A and B (1 and 2), and four known compounds (3-6) were isolated from the leaves of Tripterygium wilfordii, and one new aglycon, named wilfordoninol A (2a), was acquired by enzymatic hydrolysis of 2. The absolute stereostructures of the compounds were determined by Mosher's method and by CD. At a concentration of 10 μM, compounds 1, 3, and 5 inhibited STAT1 translocation by 38.1 ± 0.9%, 55.8 ± 0.8%, and 53.9 ± 1.0%, respectively.
authors.forename: Lin
authors.initials: L
authors.lastname: Ni
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Xing
authors.initials: X
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.forename: Chuang-Jun
authors.initials: CJ
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Tian-Tai
authors.initials: TT
authors.lastname: Zhang
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Zhang
mesh_terms: D002460:Cell Line; D005786:Gene Expression Regulation / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D045792:Norisoprenoids / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D050794:STAT1 Transcription Factor / Q000235:genetics / Q000378:metabolism; D029757:Tripterygium / Q000737:chemistry*
chemical_list: D006027:Glycosides; D045792:Norisoprenoids; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human