title: Association of 8q23-24 region (8q23.3 loci and 8q24.21 loci) with susceptibility to colorectal cancer: a systematic and updated meta-analysis.
abstract: BACKGROUND
  Several single nucleotide polymorphisms (SNPs), rs16892766 in the 8q23.3 region and rs6983267, rs10505477, rs7014346 and rs7837328 in the 8q24.21 region, have been identified by genome-wide association studies (GWAS) and a number of case-control studies to be closely associated with risk of colorectal cancer (CRC). In the present study, a meta-analysis was performed to confirm if these loci are risk factors for susceptibility to CRC, taking heterogeneity of population into consideration.
  
  
  METHODS
  The whole literature search was conducted via database of MEDLINE and Embase, through which 33 articles with 49 studies (141,899 cases and 157,536 controls) were finally included in this meta-analysis to evaluate the association between the 5 polymorphisms and risk of CRC under allelic model.
  
  
  RESULTS
  A meta-analysis of the pooled data showed that the G allele of rs6983267, the A allele of rs7014346, the T allele of rs10505477, the C allele of rs16892766 and the A allele of rs7837328 were associated with significantly increased risk of CRC under allelic model. Additionally, subgroup analyses of four SNPs (rs7837328 excluded) by ethnicity witnessed a notable association between the G allele of rs6983267 and increased risk of CRC among Caucasians, Asians and Africans. Furthermore, the C allele of rs16892766 was strongly linked with elevated risk of CRC among Caucasians and Africans. However, the A allele of rs7014346 and T allele of rs10505477 only heightened risk for CRC among Caucasians and showed no effects among Asians.
  
  
  CONCLUSIONS
  In summary, rs6983267 is a risk factor for CRC among Caucasians, Asians and Africans; rs7014346 and rs10505477 are risky genetic polymorphisms only among Caucasians; rs16892766 is a hazardous element among populations with Caucasian and African ancestry; and rs7837328 could elevate the susceptibility to CRC in a multinational group. However, more potential factors related with CRC risk should be investigated in further studies.
authors.affiliation: Department of Internal Medicine, Liaoning Cancer Hospital & Institute Shenyang 110042, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Pathology, Second Affiliated Hospital, Dalian Medical University Dalian 116023, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lv
authors.affiliation: Department of Internal Medicine, Liaoning Cancer Hospital & Institute Shenyang 110042, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Internal Medicine, Liaoning Cancer Hospital & Institute Shenyang 110042, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Shen
authors.affiliation: Department of Internal Medicine, Liaoning Cancer Hospital & Institute Shenyang 110042, China.
authors.forename: Shishi
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Endoscopy, Liaoning Cancer Hospital & Institute Shenyang 110042, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Internal Medicine, Liaoning Cancer Hospital & Institute Shenyang 110042, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Ma
keywords: 8q23.3; 8q24.21; Colorectal cancer (CRC); genome-wide association studies (GWAS); meta-analysis; single nucleotide polymorphism (SNP)