title: The potential of methylxanthine-based therapies in pediatric respiratory tract diseases.
abstract: Caffeine, theophylline and theobromine are the most known methylxanthines as they are present in coffee, tea and/or chocolate. In the last decades, a huge experimental effort has been devoted to get insight into the variety of actions that these compounds exert in humans. From such knowledge it is known that methylxanthines have a great potential in prevention, therapy and/or management of a variety of diseases. The benefits of methylxanthine-based therapies in the apnea of prematurity and their translational potential in pediatric affections of the respiratory tract are here presented.
authors.affiliation: Official College of Pharmacists of Gipuzkoa, 20006 San Sebastian, Spain. Electronic address: ainhoaonatibia@redfarma.org.
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Oñatibia-Astibia
authors.affiliation: Neuroscience Department, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain. Electronic address: martinezpinillaeva@gmail.com.
authors.forename: Eva
authors.initials: E
authors.lastname: Martínez-Pinilla
authors.affiliation: Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain; CIBERNED, Centro de Investigación en Red, Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, 28049 Madrid, Spain; Institute of Biomedicine of the University of Barcelona, IBUB, 08028, Barcelona, Spain. Electronic address: rfranco123@gmail.com.
authors.forename: Rafael
authors.initials: R
authors.lastname: Franco
mesh_terms: D000293:Adolescent; D001049:Apnea / Q000188:drug therapy*; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002110:Caffeine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003371:Cough / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D013805:Theobromine / Q000627:therapeutic use; D013806:Theophylline / Q000031:analogs & derivatives / Q000627:therapeutic use; D014970:Xanthines / Q000627:therapeutic use*
chemical_list: D001993:Bronchodilator Agents; D010726:Phosphodiesterase Inhibitors; D014970:Xanthines; C008514:methylxanthine; D002110:Caffeine; D013806:Theophylline; C029797:doxofylline; D013805:Theobromine
keywords: Airways; Apnea of prematurity; Asthma; Caffeine; Cough; Theobromine; Theophylline; Xanthine