title: Heme: Modulator of Plasma Systems in Hemolytic Diseases.
abstract: Hemolytic diseases such as sickle-cell disease, β-thalassemia, malaria, and autoimmune hemolytic anemia continue to present serious clinical hurdles. In these diseases, lysis of erythrocytes causes the release of hemoglobin and heme into plasma. Extracellular heme has strong proinflammatory potential and activates immune cells and endothelium, thus contributing to disease pathogenesis. Recent studies have revealed that heme can interfere with the function of plasma effector systems such as the coagulation and complement cascades, in addition to the activity of immunoglobulins. Any perturbation in such functions may have severe pathological consequences. In this review we analyze heme interactions with coagulation, complement, and immunoglobulins. Deciphering such interactions to better understand the complex pathogenesis of hemolytic diseases is pivotal.
authors.affiliation: Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Université Paris 06, Unité Mixte de Recherche en Santé (UMRS 1138), Centre de Recherche des Cordeliers, 75006 Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS 1138, Centre de Recherche des Cordeliers, 75006 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, UMRS 1138, Centre de Recherche des Cordeliers, F75006 Paris, France. Electronic address: lubka.roumenina@crc.jussieu.fr.
authors.forename: Lubka T
authors.initials: LT
authors.lastname: Roumenina
authors.affiliation: Centre for Cardiovascular Sciences, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, UK.
authors.forename: Julie
authors.initials: J
authors.lastname: Rayes
authors.affiliation: Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Université Paris 06, Unité Mixte de Recherche en Santé (UMRS 1138), Centre de Recherche des Cordeliers, 75006 Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS 1138, Centre de Recherche des Cordeliers, 75006 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, UMRS 1138, Centre de Recherche des Cordeliers, F75006 Paris, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lacroix-Desmazes
authors.affiliation: Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Université Paris 06, Unité Mixte de Recherche en Santé (UMRS 1138), Centre de Recherche des Cordeliers, 75006 Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS 1138, Centre de Recherche des Cordeliers, 75006 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, UMRS 1138, Centre de Recherche des Cordeliers, F75006 Paris, France. Electronic address: jordan.dimitrov@crc.jussieu.fr.
authors.forename: Jordan D
authors.initials: JD
authors.lastname: Dimitrov
mesh_terms: D000743:Anemia, Hemolytic / Q000097:blood* / Q000276:immunology* / Q000473:pathology; D000818:Animals; D003165:Complement System Proteins / Q000276:immunology*; D006418:Heme / Q000276:immunology*; D006487:Hemostasis; D006801:Humans; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology*
chemical_list: D007136:Immunoglobulins; D006418:Heme; D003165:Complement System Proteins
keywords: coagulation; complement; heme; hemolytic disorders; immunoglobulins