title: Neuroprotective Transcription Factors in Animal Models of Parkinson Disease.
abstract: A number of transcription factors, including En1/2, Foxa1/2, Lmx1a/b, Nurr1, Otx2, and Pitx3, with key roles in midbrain dopaminergic (mDA) neuron development, also regulate adult mDA neuron survival and physiology. Mouse models with targeted disruption of some of these genes display several features reminiscent of Parkinson disease (PD), in particular the selective and progressive loss of mDA neurons in the substantia nigra pars compacta (SNpc). The characterization of these animal models has provided valuable insights into various mechanisms of PD pathogenesis. Therefore, the dissection of the mechanisms and survival signalling pathways engaged by these transcription factors to protect mDA neuron from degeneration can suggest novel therapeutic strategies. The work on En1/2-mediated neuroprotection also highlights the potential of protein transduction technology for neuroprotective approaches in PD.
authors.affiliation: Center for Interdisciplinary Research in Biology (CIRB), Labex Memolife, CNRS UMR 7241, INSERM U1050, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France.
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Blaudin de Thé
authors.affiliation: Center for Interdisciplinary Research in Biology (CIRB), Labex Memolife, CNRS UMR 7241, INSERM U1050, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France.
authors.forename: Hocine
authors.initials: H
authors.lastname: Rekaik
authors.affiliation: Center for Interdisciplinary Research in Biology (CIRB), Labex Memolife, CNRS UMR 7241, INSERM U1050, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Prochiantz
authors.affiliation: Center for Interdisciplinary Research in Biology (CIRB), Labex Memolife, CNRS UMR 7241, INSERM U1050, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Fuchs
authors.affiliation: Center for Interdisciplinary Research in Biology (CIRB), Labex Memolife, CNRS UMR 7241, INSERM U1050, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France.
authors.forename: Rajiv L
authors.initials: RL
authors.lastname: Joshi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D059290:Dopaminergic Neurons / Q000378:metabolism*; D008636:Mesencephalon / Q000378:metabolism; D051379:Mice; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism; D065842:Pars Compacta / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D014157:Transcription Factors