title: [The role of reactive oxygen species (ROS) in arrhythmogenesis].
abstract: Reactive oxygen species (ROS) are the molecular oxygen derivatives that have at least one unpaired electron. Thus, ROS easily react with a number of cell structures causing a change in their functions. ROS produced in small quantities positively affect many cellular mechanisms, but in excess are responsible for the formation of oxidative stress. Oxidative stress is considered a major cause of many diseases, including cardiovascular disease. Abolition of the adverse effects of ROS on organisms in order to maintain redox homeostasis is possible thanks to antioxidants. The research conducted mainly in recent years shows that the formation of arrhythmias may also be related to the phenomenon of oxidative stress. Oxidative damage to cell membranes in particular are causing changes in ion channel activity, which proper functioning is the basis for the formation of normal heart rhythm. Antioxidants seem to play a protective role against the formation of arrhythmias.
authors.affiliation: Medical University of Lodz, Poland: Department of Electrocardiology;
authors.forename: Karol
authors.initials: K
authors.lastname: Tytman
authors.affiliation: Medical University of Lodz, Poland: Department of Electrocardiology.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kaczmarek
authors.affiliation: Medical University of Lodz, Poland: Department of General Physiology.
authors.forename: Stanisława
authors.initials: S
authors.lastname: Lipińska
authors.affiliation: Medical University of Lodz, Poland: Department of Electrocardiology;
authors.forename: Jerzy K
authors.initials: JK
authors.lastname: Wranicz
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D010100:Oxygen / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000009:adverse effects* / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D010100:Oxygen
keywords: free radicals; oxidative stress; ventricular tachycardia