title: Commentary: Accepting what we don't know will lead to progress.
authors.affiliation: Clinical Research Facility, NUI Galway, Galway, Ireland Population Health Research Institute, McMaster University, Hamilton, ON, Canada martin.odonnell@nuigalway.ie.
authors.forename: Martin
authors.initials: M
authors.lastname: O'Donnell
authors.affiliation: Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
authors.forename: Andrew
authors.initials: A
authors.lastname: Mente
authors.affiliation: Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
authors.forename: Salim
authors.initials: S
authors.lastname: Yusuf