title: Special considerations for the treatment of chronic kidney disease in the elderly.
abstract: Chronic kidney disease (CKD) is common in older adults, and its burden is expected to increase in older populations. Even if the knowledge on the approach to older patient with CKD is still evolving, current guidelines for pharmacological management of CKD does not include specific recommendations for older patients. Additionally, decision-making on renal replacement therapy (RRT) for older patients is far from being evidence-based, and despite the improvement in dialysis outcomes, RRT may cause more harm than benefit compared with conservative care when prognostic stratification is not carefully assessed. The use of comprehensive geriatric assessment tools could help clinicians in applying a more informed decision-making. Finally, physical exercise and rehabilitation interventions also represents a promising therapeutic strategy.
authors.affiliation: a Italian National Research Center on Aging, Unit of Geriatric Pharmacoepidemiology , Research Hospital of Cosenza , Cosenza , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Corsonello
authors.affiliation: a Italian National Research Center on Aging, Unit of Geriatric Pharmacoepidemiology , Research Hospital of Cosenza , Cosenza , Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Fusco
authors.affiliation: b Scientific Direction , Italian National Research Center on Aging , Ancona , Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bustacchini
authors.affiliation: b Scientific Direction , Italian National Research Center on Aging , Ancona , Italy.
authors.forename: Carlos
authors.initials: C
authors.lastname: Chiatti
authors.affiliation: b Scientific Direction , Italian National Research Center on Aging , Ancona , Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Moresi
authors.affiliation: b Scientific Direction , Italian National Research Center on Aging , Ancona , Italy.
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Bonfigli
authors.affiliation: b Scientific Direction , Italian National Research Center on Aging , Ancona , Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Di Stefano
authors.affiliation: b Scientific Direction , Italian National Research Center on Aging , Ancona , Italy.
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Lattanzio
mesh_terms: D000368:Aged; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000628:therapy*; D017582:Renal Replacement Therapy / Q000379:methods*
keywords: Chronic kidney disease; acidosis; albuminuria; anemia; comprehensive geriatric assessment; diabetes; hypertension; osteoporosis; rehabilitation; renal replacement therapy