title: LICHENS' B-OLIGOSACCHARIDES IN THE CORRECTION OF METABOLIC DISORDERS IN TYPE 2 DIABETES MELLITUS.
abstract: BACKGROUND
  Lichens of the genus Cladonia are used as medicinal plants in folk medicine. Biologically active food supplement (BAFS) on the basis of lichens p. Cladonia was derived by mechanical-chemical biotechnology in the Educational-Research-Engineering Laboratory "Mechanical-Chemical Biotechnology" of the North-Eastern Federal University (NEFU). As a result of biotech impact, the solid β-glycoside bonds are destructed on β-oligosaccharide molecules, and other groups of lichen BAS is mobilized. The content of hydrolysable carbohydrates in samples of lichen increased 8 times after mechanical activation.
  
  
  OBJECTIVE
  The aim of investigation was to study the effects of BAFS "Yagel-Detox" in patients with type 2 diabetes mellitus (DM 2).
  
  
  METHODS
  The 150 patients (group 1--100 patients receiving "Yagel-Detox", group 2--50 patients receiving placebo) with a diagnosis DM 2 were examined. The research included: general clinical and instrumental examination, biochemical and clinical blood tests. "Yagel-Detox" was used 1 capsule 3 times a day, the rate of admission was 3 months.
  
  
  RESULTS
  Clinical trials have shown that 3-month intake of BAFS "Yagel-Detox" reduces the concentration of blood glucose 1.3 1.6 times (in the control group--1.2 ÷ 1.4 times), glycosylated hemoglobin--from 9.8 ÷ 11.4% to 7.6% (in the control group--1.0%). The concentration of low-density lipoprotein (LDL) reduced on 1.3% through 6 months. Patients of both groups were on the similar tablet glucose-lowering therapy (randomized treatment), which have not been adjusted.
  
  
  CONCLUSIONS
  The obtained results allow us to recommend BAFS "Yagel-Detox" as an additional remedy to normalize blood glucose concentration in patients with DM 2.
authors.forename: B M
authors.initials: BM
authors.lastname: Kershengolts
authors.forename: L A
authors.initials: LA
authors.lastname: Sydykova
authors.forename: V V
authors.initials: VV
authors.lastname: Sharoyko
authors.forename: V V
authors.initials: VV
authors.lastname: Anshakova
authors.forename: A V
authors.initials: AV
authors.lastname: Stepanova
authors.forename: N A
authors.initials: NA
authors.lastname: Varfolomeeva
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008011:Lichens / Q000737:chemistry*; D008077:Lipoproteins, LDL / Q000032:analysis; D008297:Male; D008659:Metabolic Diseases / Q000188:drug therapy*; D009844:Oligosaccharides / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008077:Lipoproteins, LDL; D009844:Oligosaccharides; D010936:Plant Extracts