title: Magnetic resonance imaging-compatible circular mapping catheter: an in vivo feasibility and safety study.
abstract: OBJECTIVE
  Interventional cardiac catheter mapping is routinely guided by X-ray fluoroscopy, although radiation exposure remains a significant concern. Feasibility of catheter ablation for common flutter has recently been demonstrated under magnetic resonance imaging (MRI) guidance. The benefit of catheter ablation under MRI could be significant for complex arrhythmias such as atrial fibrillation (AF), but MRI-compatible multi-electrode catheters such as Lasso have not yet been developed. This study aimed at demonstrating the feasibility and safety of using a multi-electrode catheter [magnetic resonance (MR)-compatible Lasso] during MRI for cardiac mapping. We also aimed at measuring the level of interference between MR and electrophysiological (EP) systems.
  
  
  RESULTS
  Experiments were performed in vivo in sheep (N = 5) using a multi-electrode, circular, steerable, MR-compatible diagnostic catheter. The most common MRI sequences (1.5T) relevant for cardiac examination were run with the catheter positioned in the right atrium. High-quality electrograms were recorded while imaging with a maximal signal-to-noise ratio (peak-to-peak signal amplitude/peak-to-peak noise amplitude) ranging from 5.8 to 165. Importantly, MRI image quality was unchanged. Artefacts induced by MRI sequences during mapping were demonstrated to be compatible with clinical use. Phantom data demonstrated that this 10-pole circular catheter can be used safely with a maximum of 4°C increase in temperature.
  
  
  CONCLUSIONS
  This new MR-compatible 10-pole catheter appears to be safe and effective. Combining MR and multipolar EP in a single session offers the possibility to correlate substrate information (scar, fibrosis) and EP mapping as well as online monitoring of lesion formation and electrical endpoint.
authors.affiliation: IHU LIRYC/CRCTB, INSERM U1045, University of Bordeaux, Bordeaux, France.|Biomedical Ultrasonics, Biotherapy & Biopharmaceuticals Laboratory (BUBBL), Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus Research Building, Headington, Oxford OX3 7DQ, UK.
authors.forename: Delphine
authors.initials: D
authors.lastname: Elbes
authors.affiliation: IHU LIRYC/CRCTB, INSERM U1045, University of Bordeaux, Bordeaux, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Magat
authors.affiliation: Biosense Webster, Diamond Bar, USA.
authors.forename: Assaf
authors.initials: A
authors.lastname: Govari
authors.affiliation: Biosense Webster, Diamond Bar, USA.
authors.forename: Yaron
authors.initials: Y
authors.lastname: Ephrath
authors.affiliation: Plateforme Technologique d'Innovation Biomedical, Universite de Bordeaux, Pessac, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Vieillot
authors.affiliation: Biosense Webster, Diamond Bar, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Beeckler
authors.affiliation: University of Western Australia, Perth, Western Australia.
authors.forename: Rukshen
authors.initials: R
authors.lastname: Weerasooriya
authors.affiliation: IHU LIRYC/CRCTB, INSERM U1045, University of Bordeaux, Bordeaux, France.|Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Jais
authors.affiliation: IHU LIRYC/CRCTB, INSERM U1045, University of Bordeaux, Bordeaux, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Quesson
mesh_terms: D000818:Animals; D016477:Artifacts; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D062906:Cardiac Catheters / Q000009:adverse effects; D022062:Electrophysiologic Techniques, Cardiac / Q000009:adverse effects / Q000295:instrumentation*; D004867:Equipment Design; D004868:Equipment Failure; D005240:Feasibility Studies; D008279:Magnetic Resonance Imaging / Q000009:adverse effects / Q000295:instrumentation; D008422:Materials Testing; D023421:Models, Animal; D019047:Phantoms, Imaging; D011237:Predictive Value of Tests; D034561:Sheep, Domestic; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio
keywords: Catheter mapping electrophysiology; Magnetic resonance imaging