title: The evaluation of carotid intima-media thickness and mean platelet volume values and correlation with cardiac functions in obese children.
abstract: BACKGROUND
  Obesity is associated with many risk factors, such as hyperlipidemia, hyperinsulinemia, hypertension and leads to early atherosclerosis. The aim of this study was to investigate the relation of the mean platelet volume (MPV) and the carotid intima media thickness (CIMT) on cardiac functions among obese children.
  
  
  METHODS
  Sixty obese children, with body mass index percentile were >95% and forty eight healthy controls were enrolled in the study. Triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), thyroid function tests, hemoglobin, white blood cell, MPV and insulin resistance were evaluated. CIMT was measured by using high-resolution ultrasound and echocardiography was performed to all individuals.
  
  
  RESULTS
  MPV and CIMT values were found significantly higher in obese children than controls. There was positive correlation between CIMT and age, body surface area (BSA), systolic and diastolic blood pressure, left ventricular meridional end-systolic wall stress (ESWSm), myocardial fiber stress (MFS), stroke volume (SV) and insulin and negative correlation with left ventricle end-systolic elastance by single beat technique (Ees(sb)) and arterial elastance (Ea). There was no correlation between LVM, cardiac risk profiles and CIMT. Multiple stepwise regression analyses revealed that ESWSm (β=0.337, P=0.049) was only independent factor on CIMT. MPV values showed negative correlation with ALT, AST, Free T4, thyroid stimulating hormone and positive correlation with age and BSA.
  
  
  CONCLUSIONS
  Current study showed that obesity has an independent impact on CIMT and MPV values in children. Increased CIMT in obese children leads significant increase in ESWSm and decrease in Ea and Ees(sb).
authors.affiliation: Department of Pediatrics, Medical Faculty, Bozok University Yozgat, Turkey.
authors.forename: Esra Akyüz
authors.initials: EA
authors.lastname: Özkan
authors.affiliation: Department of Pediatric Cardiology, Medical Faculty, Bozok University Yozgat, Turkey.
authors.forename: Hashem E
authors.initials: HE
authors.lastname: Khosroshahi
authors.affiliation: Department of Radiology, Medical Faculty, Bozok University Yozgat, Turkey.
authors.forename: Halil İbrahim
authors.initials: Hİ
authors.lastname: Serin
authors.affiliation: Department of Internal Medicine, Medical Faculty, Bozok University Yozgat, Turkey.
authors.forename: Zeynep Tuba
authors.initials: ZT
authors.lastname: Özdemir
authors.affiliation: Department of Public Health, Medical Faculty, Bozok University Yozgat, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Kılıç
authors.affiliation: Department of Biochemistry, Medical Faculty, Bozok University Yozgat, Turkey.
authors.forename: Meral
authors.initials: M
authors.lastname: Ekim
authors.affiliation: Department of Pediatrics, Medical Faculty, Bozok University Yozgat, Turkey.
authors.forename: U Aliye
authors.initials: UA
authors.lastname: Geçit
authors.affiliation: Department of Pediatrics, Medical Faculty, Bozok University Yozgat, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Domur
keywords: Cardiac functions; carotid intima-media thickness; children; mean platelet volume; obese