title: Computational prediction of Mycoplasma hominis proteins targeting in nucleus of host cell and their implication in prostate cancer etiology.
abstract: Cancer has long been assumed to be a genetic disease. However, recent evidence supports the enigmatic connection of bacterial infection with the growth and development of various types of cancers. The cause and mechanism of the growth and development of prostate cancer due to Mycoplasma hominis remain unclear. Prostate cancer cells are infected and colonized by enteroinvasive M. hominis, which controls several factors that can affect prostate cancer growth in susceptible persons. We investigated M. hominis proteins targeting the nucleus of host cells and their implications in prostate cancer etiology. Many vital processes are controlled in the nucleus, where the proteins targeting M. hominis may have various potential implications. A total of 29/563 M. hominis proteins were predicted to target the nucleus of host cells. These include numerous proteins with the capability to alter normal growth activities. In conclusion, our results emphasize that various proteins of M. hominis targeted the nucleus of host cells and were involved in prostate cancer etiology through different mechanisms and strategies.
authors.affiliation: Nanomedicine & Biotechnology Research Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh, 11451, Saudi Arabia. khan.shahanavaj@gmail.com.|Department of Bioscience, Shri Ram Group of College (SRGC), Muzaffarnagar, UP, India. khan.shahanavaj@gmail.com.
authors.forename: Shahanavaj
authors.initials: S
authors.lastname: Khan
authors.affiliation: Research Center, College of Computer and Information Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Zakariah
authors.affiliation: School of Science and Engineering, Malaysia University of Science and Technology, Petaling Jaya, Malaysia.
authors.forename: Sellappan
authors.initials: S
authors.lastname: Palaniappan
mesh_terms: D017209:Apoptosis; D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology*; D059447:Cell Cycle Checkpoints; D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism; D003043:Cocarcinogenesis; D019295:Computational Biology; D004249:DNA Damage; D003663:Decision Trees; D004847:Epithelial Cells / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D008297:Male; D008970:Molecular Weight; D009175:Mycoplasma Infections / Q000382:microbiology*; D019535:Mycoplasma hominis / Q000378:metabolism* / Q000472:pathogenicity; D019913:Nuclear Localization Signals; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology; D011472:Prostatitis / Q000382:microbiology*; D020543:Proteome; D060388:Support Vector Machine
chemical_list: D001426:Bacterial Proteins; D019913:Nuclear Localization Signals; D020543:Proteome
keywords: Etiology; Host nucleus; In silico; Mycoplasma hominis; Prostate cancer; Protein targeting