title: Nonlinear Resistance Training Enhances the Lipid Profile and Reduces Inflammation Marker in People Living With HIV: A Randomized Clinical Trial.
abstract: Highly active antiretroviral therapy (HAART) is associated with high total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), triglyceride (TG), and C-reactive protein (CRP) levels. The natural course of the HIV infection reduces the high-density lipoprotein level (HDL-c). Thus, physical exercise plays a key role in reducing the effects of HAART and HIV.
  
  
  
  Thirty people living with HIV (PLHIV) were randomized to the nonlinear resistance training (NLRT) and control (CON) groups. The NLRT group underwent 12 weeks of resistance training, whereas the CON group maintained usual daily activities. All volunteers underwent anthropometric, body composition, and biochemical assessments at the beginning and end of 12 weeks.
  
  
  
  After 12 weeks, the NLRT group had increased lean body mass (P < .0001), and a reduction in body fat mass (P < .0001) and body fat percentage (P < .0001). The levels of TC (P < .0001), LDL-c (P = .049), TG (P < .0001), and CRP (P = .004) were reduced, and the HDL-c level increased (P < .0001).
  
  
  
  Twelve weeks of NLRT causes beneficial changes in the body composition, lipid profile, and inflammation markers in PLHIV, and it can be used in this patient population.
authors.affiliation: Post-Graduate Program in Physical Education, Federal University of Triângulo Mineiro, Uberaba/MG, Brazil.
authors.forename: Hugo Ribeiro
authors.initials: HR
authors.lastname: Zanetti
authors.forename: Lucas Gonçalves
authors.initials: LG
authors.lastname: da Cruz
authors.forename: Camilo Luís
authors.initials: CL
authors.lastname: Lourenço
authors.forename: Giovana Castilho
authors.initials: GC
authors.lastname: Ribeiro
authors.forename: Marco Aurélio
authors.initials: MA
authors.lastname: Ferreira de Jesus Leite
authors.forename: Fernando Freitas
authors.initials: FF
authors.lastname: Neves
authors.forename: Mário Leon
authors.initials: ML
authors.lastname: Silva-Vergara
authors.forename: Edmar Lacerda
authors.initials: EL
authors.lastname: Mendes
mesh_terms: D000293:Adolescent; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D015444:Exercise / Q000502:physiology*; D005260:Female; D015658:HIV Infections / Q000628:therapy*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D055070:Resistance Training / Q000379:methods*; D055815:Young Adult
chemical_list: D008055:Lipids