title: Adjuvant properties of water extractable arabinoxylans with different structural features from wheat flour against model antigen ovalbumin.
abstract: Despite the numerous benefits of AX on the immune system and gut bacteria, the potential adjuvant activity of WEAX on immune responses has not been adequately investigated. In the present study, three kinds of WEAX with different structural features were obtained and their adjuvant potential on the specific cellular and humoral immune responses in ovalbumin (OVA) immunized mice were assessed. Our data demonstrated that WEAX had potent effects on innate and acquired immune responses through up-regulating the NK cell activation and promoting the Th2 type immune response. Furthermore, this study also elucidated the possible relationship between the adjuvant activity of WEAX and the structure. Compared with the other characteristics of the WEAX, we found that the immunomodulatory activity may be related to their content of ferulic acid, and not to the molecular weight.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. lcao@implad.ac.cn and Xinjiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi, Xinjiang Province 830002, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Ma
authors.affiliation: Institute of Agro-food Science & Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.affiliation: Xinjiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi, Xinjiang Province 830002, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wei
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. lcao@implad.ac.cn.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Huo
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. lcao@implad.ac.cn.
authors.forename: Canhong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. lcao@implad.ac.cn.
authors.forename: Dongyu
authors.initials: D
authors.lastname: Liu
authors.affiliation: Institute of Agro-food Science & Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
authors.forename: Sumei
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. lcao@implad.ac.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Cao
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D005433:Flour / Q000032:analysis; D015847:Interleukin-4 / Q000235:genetics / Q000276:immunology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010047:Ovalbumin / Q000276:immunology*; D010936:Plant Extracts / Q000737:chemistry* / Q000276:immunology / Q000302:isolation & purification / Q000494:pharmacology*; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology; D014908:Triticum / Q000737:chemistry* / Q000276:immunology; D014990:Xylans / Q000737:chemistry* / Q000276:immunology / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D010936:Plant Extracts; D014990:Xylans; D015847:Interleukin-4; D010047:Ovalbumin; C085118:arabinoxylan