title: Management of side effects of mTOR inhibitors in tuberous sclerosis patients.
abstract: mTOR inhibitors represent a relatively new therapeutic option in the management of patients affected by tuberous sclerosis complex (TSC). Randomized clinical trials support the use of everolimus in the treatment of subependymal giant cell astrocytomas (SEGA) and renal angiomyolipomas (AML) related to TSC. Accumulating data suggest also systemic disease-modifying potential of mTOR inhibitors. Given that increasing number of patients with TSC receive mTOR inhibitors, the issue of adverse events associated with this therapy becomes practically important. In the present study we provide the overview of clinical manifestations and therapeutic options for the most common adverse events related to mTOR inhibitors in TSC patients.
authors.affiliation: Department of Neurology and Epileptology, The Children's Memorial Health Institute, Warszawa, Poland. Electronic address: sadowski.ks@gmail.com.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Sadowski
authors.affiliation: Department of Neurology and Epileptology, The Children's Memorial Health Institute, Warszawa, Poland. Electronic address: kotulska.jozwiak@gmail.com.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kotulska
authors.affiliation: Department of Neurology and Epileptology, The Children's Memorial Health Institute, Warszawa, Poland; Department of Pediatric Neurology, Warsaw Medical University, Warszawa, Poland. Electronic address: sergiusz.jozwiak@gmail.com.
authors.forename: Sergiusz
authors.initials: S
authors.lastname: Jóźwiak
mesh_terms: D019468:Disease Management; D000068338:Everolimus / Q000009:adverse effects*; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D020123:Sirolimus / Q000009:adverse effects*; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D014402:Tuberous Sclerosis / Q000188:drug therapy*
chemical_list: D047428:Protein Kinase Inhibitors; D000068338:Everolimus; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus
keywords: Everolimus; Sirolimus; Tuberous sclerosis complex; mTOR inhibitors