title: Gut Microbiota of Nonalcoholic Fatty Liver Disease.
abstract: The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on developing hepatic fatty infiltration and its progression. Current literature supports a possible role for gut microbiota in the development of liver steatosis, inflammation and fibrosis. We also review the literature on possible interventions for NAFLD that target the gut microbiota.
authors.affiliation: Digestive Diseases and Nutrition Center, Department of Pediatrics, Women and Children's Hospital of Buffalo, The State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA. rabdou@upa.chob.edu.
authors.forename: Reham M
authors.identifier: http://orcid.org/0000-0003-4942-7817
authors.initials: RM
authors.lastname: Abdou
authors.affiliation: Digestive Diseases and Nutrition Center, Department of Pediatrics, Women and Children's Hospital of Buffalo, The State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA.|, 3435 Main Street, 413 Biomedical Research Building, Buffalo, NY, 14214, USA.
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Digestive Diseases and Nutrition Center, Department of Pediatrics, Women and Children's Hospital of Buffalo, The State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Baker
authors.affiliation: Digestive Diseases and Nutrition Center, Department of Pediatrics, Women and Children's Hospital of Buffalo, The State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA.
authors.forename: Susan S
authors.initials: SS
authors.lastname: Baker
mesh_terms: D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D007249:Inflammation / Q000382:microbiology; D008103:Liver Cirrhosis / Q000382:microbiology; D065626:Non-alcoholic Fatty Liver Disease / Q000382:microbiology*
keywords: Fibrosis; Inflammation; Microbiota and intestinal permeability; NAFLD; NASH; Steatosis