title: Clinical Evaluation of a Novel and Mobile Autism Risk Assessment.
abstract: The Mobile Autism Risk Assessment (MARA) is a new, electronically administered, 7-question autism spectrum disorder (ASD) screen to triage those at highest risk for ASD. Children 16 months-17 years (N = 222) were screened during their first visit in a developmental-behavioral pediatric clinic. MARA scores were compared to diagnosis from the clinical encounter. Participant median age was 5.8 years, 76.1 % were male, and most participants had an intelligence/developmental quotient score >85; 69 of the participants (31 %) received a clinical diagnosis of ASD. The sensitivity of the MARA in detecting ASD was 89.9 % [95 % CI = 82.7-97]; the specificity was 79.7 % [95 % CI = 73.4-86.1]. In a high-risk clinical setting, the MARA shows promise as a screen to distinguish ASD from other developmental/behavioral disorders.
authors.affiliation: Division of Systems Medicine, Department of Pediatrics, Stanford University, 1265 Welch Road, Stanford, CA, 94305, USA.|Department of Biomedical Data Science, Stanford University, 1265 Welch Road, Stanford, CA, 94305, USA.
authors.forename: Marlena
authors.initials: M
authors.lastname: Duda
authors.affiliation: Division of Systems Medicine, Department of Pediatrics, Stanford University, 1265 Welch Road, Stanford, CA, 94305, USA.|Department of Biomedical Data Science, Stanford University, 1265 Welch Road, Stanford, CA, 94305, USA.
authors.forename: Jena
authors.initials: J
authors.lastname: Daniels
authors.affiliation: Division of Systems Medicine, Department of Pediatrics, Stanford University, 1265 Welch Road, Stanford, CA, 94305, USA. dpwall@stanford.edu.|Department of Biomedical Data Science, Stanford University, 1265 Welch Road, Stanford, CA, 94305, USA. dpwall@stanford.edu.
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Wall
mesh_terms: D000293:Adolescent; D000067877:Autism Spectrum Disorder / Q000175:diagnosis*; D001321:Autistic Disorder / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008403:Mass Screening; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity
keywords: Autism detection; Autism screening; Clinical validation; Machine learning