title: Mitochondrial redox status as a target for cardiovascular disease.
abstract: Mitochondria are major players in cellular energetics, oxidative stress and programmed cell death. Mitochondrial dynamics regulate and integrate these functions. Mitochondrial dysfunction is involved in cardiac hypertrophy, hypertension and myocardial ischemia/reperfusion injury. Reactive oxygen species generation is modulated by the fusion-fission pathway as well as key proteins such as sirtuins that act as metabolic sensors of cellular energetics. Mitochondrial redox status has thus become a good target for therapy against cardiovascular diseases. Recently, there is an influx of studies garnered towards assessing the beneficial effects of mitochondrial targeted antioxidants, drugs modulating the fusion-fission proteins, sirtuins, and other mitochondrial processes as potential cardio-protecting agents.
authors.affiliation: School of Arts & Sciences, Bluefield State College, Basic Science Building B213, 219 Rock Street, Bluefield, WV 24701, USA.
authors.forename: James W
authors.initials: JW
authors.lastname: Walters
authors.affiliation: Department of Pharmacology, Physiology & Toxicology, Joan C Edwards School of Medicine, Marshall University, One John Marshall Dr, Huntington, WV 25755, USA.
authors.forename: Deborah
authors.initials: D
authors.lastname: Amos
authors.affiliation: Department of Pharmacology, Physiology & Toxicology, Joan C Edwards School of Medicine, Marshall University, One John Marshall Dr, Huntington, WV 25755, USA.
authors.forename: Kristeena
authors.initials: K
authors.lastname: Ray
authors.affiliation: Department of Pharmacology, Physiology & Toxicology, Joan C Edwards School of Medicine, Marshall University, One John Marshall Dr, Huntington, WV 25755, USA. Electronic address: santanam@marshall.edu.
authors.forename: Nalini
authors.initials: N
authors.lastname: Santanam
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000187:drug effects*; D010084:Oxidation-Reduction / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D002316:Cardiotonic Agents; D017382:Reactive Oxygen Species