title: Point-of-Need bioanalytics based on planar optical interferometry.
abstract: This review brings about a comprehensive presentation of the research on interferometric transducers, which have emerged as extremely promising candidates for viable, truly-marketable solutions for PoN applications due to the attested performance that has reached down to 10(-8) in term of effective refractive index changes. The review explores the operation of the various interferometric architectures along with their design, fabrication, and analytical performance aspects. The issues of biosensor functionalization and immobilization of receptors are also addressed. As a conclusion, the comparison among them is attempted in order to delve into and acknowledge their current limitations, and define the future trends.
authors.affiliation: Optical Biosensors Lab, Institute of Nanoscience and Nanotechnology, NCSR "Demokritos", 15310 Athens, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Makarona
authors.affiliation: Immunoassay/Immunosensors Lab, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, NCSR "Demokritos", 15310 Athens, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Petrou
authors.affiliation: Immunoassay/Immunosensors Lab, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, NCSR "Demokritos", 15310 Athens, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Kakabakos
authors.affiliation: Optical Biosensors Lab, Institute of Nanoscience and Nanotechnology, NCSR "Demokritos", 15310 Athens, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Misiakos
authors.affiliation: Optical Biosensors Lab, Institute of Nanoscience and Nanotechnology, NCSR "Demokritos", 15310 Athens, Greece. Electronic address: i.raptis@inn.demokritos.gr.
authors.forename: I
authors.initials: I
authors.lastname: Raptis
mesh_terms: D004867:Equipment Design; D007368:Interferometry / Q000295:instrumentation / Q000379:methods*; D019095:Point-of-Care Systems; D018511:Systems Integration
keywords: Biofunctionalization; Biosensor; Interferometry; Label-free detection; Planar waveguide; Point-of-Need