title: Gold vs Rhodium Catalysis: Tuning Reactivity through Catalyst Control in the C-H Alkynylation of Isoquinolones.
abstract: A site-selective C-4/C-8 alkynylation of isoquinolones catalyzed by gold and rhodium complexes is reported. A broad range of synthetically useful functional groups (-F, -Cl, -Br, -CF3, -OMe, alkyl, etc.) were tolerated, providing an efficient and robust protocol for the synthesis either C-4- or C-8-alkynylated isoquinolones.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune 411008, India.|Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110025, India.
authors.forename: Aslam C
authors.initials: AC
authors.lastname: Shaikh
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune 411008, India.|Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110025, India.
authors.forename: Dinesh R
authors.initials: DR
authors.lastname: Shinde
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune 411008, India.|Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110025, India.
authors.forename: Nitin T
authors.initials: NT
authors.lastname: Patil