title: Association of long-term blood pressure variability and brachial-ankle pulse wave velocity: a retrospective study from the APAC cohort.
abstract: We investigated associations between long-term blood pressure variability (BPV) and brachial-ankle pulse wave velocity (baPWV). Within the Asymptomatic Polyvascular Abnormalities Community (APAC) study, we retrospectively collected long-term BPV and baPWV measures. Long-term BPV was calculated using the mean and standard deviation of systolic blood pressure (SBP) across 4 years based on annual values of SBP. In total, 3,994 subjects (2,284 men) were eligible for inclusion in this study. We stratified the study population into four SBP quartiles. Left and right baPWV was higher in participants with long-term SBPV in the fourth quartile compared with the first quartile (left: 1,725 ± 488 vs. 1,461 ± 340 [p < 0.001]; right: 1,722 ± 471 vs. 1,455 ± 341 [p < 0.001], respectively). We obtained the same result for total baPWV (fourth vs. first quartile: 1,772 ± 429 vs. 1,492 ± 350 [p < 0.001]). Furthermore, there was a trend for gradually increased baPWV (≥1,400 cm/s) with increased SBPV (p < 0.001). After multivariable adjustment, baPWV was positively correlated with long-term BPV (p < 0.001). In conclusion, long-term BPV is significantly associated with arterial stiffness as assessed by baPWV.
authors.affiliation: Graduate School, North China University of Science and Technology, Tangshan, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Graduate School, North China University of Science and Technology, Tangshan, China.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.|Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
authors.forename: Anxin
authors.initials: A
authors.lastname: Wang
authors.affiliation: Graduate School, North China University of Science and Technology, Tangshan, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: An
authors.affiliation: Graduate School, North China University of Science and Technology, Tangshan, China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Graduate School, North China University of Science and Technology, Tangshan, China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Graduate School, North China University of Science and Technology, Tangshan, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Liu
authors.affiliation: Graduate School, North China University of Science and Technology, Tangshan, China.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Ruan
authors.affiliation: Department of Cardiology,Tangshan People's Hospital, Tangshan, China.
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China.
authors.forename: Shouling
authors.initials: S
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D058070:Asymptomatic Diseases; D001794:Blood Pressure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D063177:Pulse Wave Analysis; D012189:Retrospective Studies; D014652:Vascular Diseases / Q000453:epidemiology* / Q000503:physiopathology*