title: Mechanism of action of brexpiprazole: comparison with aripiprazole.
abstract: Brexpiprazole is a new therapeutic agent that was recently approved for the treatment of schizophrenia and for the adjunctive treatment of major depressive disorder. Brexpiprazole has features that both overlap and contrast with a related molecule, aripiprazole, and these features are discussed here.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Stahl
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology*; D000068180:Aripiprazole / Q000494:pharmacology*; D003865:Major Depressive Disorder / Q000188:drug therapy; D018491:Dopamine Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D015363:Quinolones / Q000494:pharmacology* / Q000627:therapeutic use; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects; D044402:Receptor, Serotonin, 5-HT2A / Q000187:drug effects; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects; D017448:Receptors, Dopamine D2 / Q000819:agonists; D012559:Schizophrenia / Q000188:drug therapy; D058825:Serotonin 5-HT1 Receptor Agonists / Q000494:pharmacology; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000494:pharmacology; D018490:Serotonin Agents / Q000494:pharmacology* / Q000627:therapeutic use; D013876:Thiophenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D014150:Antipsychotic Agents; D018491:Dopamine Agonists; D015363:Quinolones; D044402:Receptor, Serotonin, 5-HT2A; D018340:Receptors, Adrenergic, alpha-1; D017448:Receptors, Dopamine D2; D058825:Serotonin 5-HT1 Receptor Agonists; D058830:Serotonin 5-HT2 Receptor Antagonists; D018490:Serotonin Agents; D013876:Thiophenes; D044282:Receptor, Serotonin, 5-HT1A; C000591922:brexpiprazole; D000068180:Aripiprazole