title: Assessment of CD-105 as an Angiogenic Modulator in Odontogenic Myxomas and Dental Follicles.
abstract: Aim Odontogenic myxoma is a benign intraosseous neoplasm of the jaws, with a locally aggressive behavior and a high recurrence rate. CD-105 is a homodimeric cell membrane glycoprotein and is a component of the TGF-β1 growth factor receptor complex that modulates angiogenesis by regulating the proliferation, differentiation and cellular migration. The aim of this study is to quantify the microvascular density of the odontogenic myxoma based on the expression of CD-105. Materials and Methods The analysis included 18 odontogenic myxoma and 18 dental follicles as controls. A standard immunohistochemical procedure was performed with the CD-105 antibody. Five representative fields (40×) of the odontogenic myxoma and the dental follicles were selected to determine the microvascular density, which was then followed by a descriptive and comparative statistical analysis. Results Dental follicles presented a significantly higher microvascular density compared with odontogenic myxoma (P = .001). The odontogenic myxoma smaller than 3 cm showed a greater microvascular density than those larger than 3 cm in size (P > .05), and the microvascular density was lower in large odontogenic myxomas as compared with the dental follicles (P = .003). Conclusion A weaker expression of CD-105 in odontogenic myxoma might indicate a lower angiogenic activity, suggesting that vascular proliferation has a limited role in the growth mechanisms and in the aggressive behavior of this neoplasm.
authors.affiliation: University of the Basque Country (UPV/EHU), Vizcaya, Spain maricarmen_galvan@hotmail.com.
authors.forename: María
authors.initials: M
authors.lastname: Del Carmen González-Galván
authors.affiliation: University of the Basque Country (UPV/EHU), Vizcaya, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Aguirre-Urizar
authors.affiliation: Universidad de la Republica (UDELAR), Montevideo, Uruguay.
authors.forename: Ronell
authors.initials: R
authors.lastname: Bologna-Molina
authors.affiliation: Hospital General "Dr Dario Fernandez Fierro" ISSSTE, Mexico City, Mexico.
authors.forename: J Eduardo
authors.initials: JE
authors.lastname: Farfán-Morales
authors.affiliation: University of Malta, Malta.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Gainza-Cirauqui
authors.affiliation: University of the Basque Country (UPV/EHU), Vizcaya, Spain.
authors.forename: Xabier
authors.initials: X
authors.lastname: Marichalar-Mendia
authors.affiliation: Universidad Autónoma Metropolitana-Xochimilco, Mexico City, Mexico.
authors.forename: Adalberto
authors.initials: A
authors.lastname: Mosqueda-Taylor
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D003795:Dental Sac / Q000378:metabolism*; D000071063:Endoglin / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D009232:Myxoma / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D009808:Odontogenic Tumors / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin
keywords: CD-105; dental follicle; microvascular density; odontogenic myxoma