title: Left Main Stenting in Comparison With Surgical Revascularization: 10-Year Outcomes of the (Left Main Coronary Artery Stenting) LE MANS Trial.
abstract: OBJECTIVE
  This study has reported 10-year clinical follow-up of patients enrolled in the prospective, randomized LE MANS (Left Main Stenting) trial.
  
  
  BACKGROUND
  The very long-term outcome after left main stenting in comparison with surgical revascularization remains unknown.
  
  
  METHODS
  In this prospective, multicenter trial, we randomly assigned 105 patients with unprotected left main coronary artery stenosis with low and medium complexity of coexisting coronary artery disease according to SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score to percutaneous coronary intervention (PCI) with stenting (n = 52) or coronary artery bypass grafting (CABG) (n = 53). Drug-eluting stents were implanted in 35%, whereas arterial grafts to the left anterior descending artery were utilized in 81%. Currently, the mean long-term follow-up was collected at 9.8 ± 1.0 years. Follow up for all-cause mortality is complete, whereas the incidence of major adverse cardiovascular and cerebral events (MACCE) was reported from 90% of patients. Ambulatory follow-up was completed in 46 (43.9%) patients.
  
  
  RESULTS
  At 10 years, there was a trend toward higher ejection fraction in stenting when compared with surgery (54.9 ± 8.3% vs. 49.8 ± 10.3%; p = 0.07). The mortality (21.6% vs. 30.2%; p = 0.41) and MACCE (51.1% vs. 64.4%; p = 0.28) were statistically not different between groups; however, numerically the difference was in favor of stenting. Similarly, there was no difference in the occurrence of myocardial infarction (8.7 vs. 10.4%; p = 0.62), stroke (4.3 vs. 6.3%; p = 0.68), and repeated revascularization rates (26.1% vs. 31.3%; p = 0.64). The probability of very long-term survival up to 14 years was comparable between PCI and CABG (74.2% vs. 67.5%; p = 0.34; hazard ratio: 1.45, 95% confidence interval: 0.67 to 3.13); however, there was a trend toward higher MACCE-free survival in the PCI group (34.7% vs. 22.1%; p = 0.06; hazard ratio: 1.71, 95% confidence interval: 0.97 to 2.99).
  
  
  CONCLUSIONS
  In patients with unprotected left main coronary artery stenosis with low and medium complexity of coexisting coronary artery disease, stenting offers numerically, but statistically nonsignificant, favorable long-term outcome up to 10 years in terms of safety and efficacy outcome measures, therefore, constitutes an alternative therapy for CABG.
authors.affiliation: American Heart of Poland, Center for Cardiovascular Research and Development, Katowice, Poland; Medical University of Silesia, Katowice, Poland.
authors.forename: Pawel E
authors.initials: PE
authors.lastname: Buszman
authors.affiliation: American Heart of Poland, Center for Cardiovascular Research and Development, Katowice, Poland; IIIrd Clinical Department of Cardiology of Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze, Poland. Electronic address: p.buszman@ahp-ccrd.org.
authors.forename: Piotr P
authors.initials: PP
authors.lastname: Buszman
authors.affiliation: American Heart of Poland, Center for Cardiovascular Research and Development, Katowice, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Banasiewicz-Szkróbka
authors.affiliation: American Heart of Poland, Center for Cardiovascular Research and Development, Katowice, Poland.
authors.forename: Krzysztof P
authors.initials: KP
authors.lastname: Milewski
authors.affiliation: American Heart of Poland, Center for Cardiovascular Research and Development, Katowice, Poland.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Żurakowski
authors.affiliation: American Heart of Poland, Center for Cardiovascular Research and Development, Katowice, Poland.
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Orlik
authors.affiliation: American Heart of Poland, Center for Cardiovascular Research and Development, Katowice, Poland.
authors.forename: Magda
authors.initials: M
authors.lastname: Konkolewska
authors.affiliation: American Heart of Poland, Center for Cardiovascular Research and Development, Katowice, Poland.
authors.forename: Błażej
authors.initials: B
authors.lastname: Trela
authors.affiliation: American Heart of Poland, Center for Cardiovascular Research and Development, Katowice, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Janas
authors.affiliation: University of Texas Health Sciences, San Antonio, Texas.
authors.forename: Jack L
authors.initials: JL
authors.lastname: Martin
authors.affiliation: Sharpe Strumia Research Foundation, Bryn Mawr, Pennsylvania.
authors.forename: R Stefan
authors.initials: RS
authors.lastname: Kiesz
authors.affiliation: American Heart of Poland, Center for Cardiovascular Research and Development, Katowice, Poland; Medical University of Silesia, Katowice, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Bochenek
mesh_terms: D000368:Aged; D002317:Cardiovascular Agents / Q000627:therapeutic use; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000401:mortality; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D018572:Disease-Free Survival; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D012307:Risk Factors; D015607:Stents; D020521:Stroke / Q000209:etiology; D013318:Stroke Volume; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left
chemical_list: D002317:Cardiovascular Agents
keywords: coronary artery bypass surgery; left main disease; stenting; ten-year outcome