title: Mechanisms of vascularization in murine models of primary and metastatic tumor growth.
abstract: Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative vascularization mechanisms, such as intussusceptive microvascular growth, vessel co-option, and glomeruloid angiogenesis. Importantly, in response to anti-angiogenic therapies, malignant tumors can switch from one vascularization mechanism to another. In this article, we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology.
authors.affiliation: 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary. bedina@korb1.sote.hu.|Department of Thoracic Surgery, Semmelweis University-National Institute of Oncology, Budapest, 1122, Hungary. bedina@korb1.sote.hu.|Hungarian Academy of Sciences Postdoctoral Research Programme, Budapest, 1051, Hungary. bedina@korb1.sote.hu.
authors.forename: Edina
authors.initials: E
authors.lastname: Bugyik
authors.affiliation: Department of Thoracic Surgery, Semmelweis University-National Institute of Oncology, Budapest, 1122, Hungary. renyi-vamos.ferenc@med.semmelweis-univ.hu.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Renyi-Vamos
authors.affiliation: 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary. szabvan@freemail.hu.
authors.forename: Vanessza
authors.initials: V
authors.lastname: Szabo
authors.affiliation: 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary. dkata@korb1.sote.hu.
authors.forename: Katalin
authors.initials: K
authors.lastname: Dezso
authors.affiliation: 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary. ecker.nora@gmail.com.
authors.forename: Nora
authors.initials: N
authors.lastname: Ecker
authors.affiliation: 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary. rokusza@hotmail.com.
authors.forename: Andras
authors.initials: A
authors.lastname: Rokusz
authors.affiliation: 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary. pdrnagy@gmail.com.
authors.forename: Peter
authors.initials: P
authors.lastname: Nagy
authors.affiliation: Department of Thoracic Surgery, Semmelweis University-National Institute of Oncology, Budapest, 1122, Hungary. balazs.dome@meduniwien.ac.at.|Department of Thoracic Surgery, Medical University of Vienna, 1090, Vienna, Austria. balazs.dome@meduniwien.ac.at.|Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, 1090, Vienna, Austria. balazs.dome@meduniwien.ac.at.
authors.forename: Balazs
authors.initials: B
authors.lastname: Dome
authors.affiliation: 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary. paku@korb1.sote.hu.|Tumor Progression Research Group, Joint Research Organization of the Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary. paku@korb1.sote.hu.
authors.forename: Sandor
authors.initials: S
authors.lastname: Paku
mesh_terms: D000818:Animals; D042783:Endothelial Cells / Q000473:pathology*; D006801:Humans; D051379:Mice; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000473:pathology*