title: New Acylated Flavonol Glycosides and a Phenolic Profile of Pritzelago alpina, a Forgotten Edible Alpine Plant.
abstract: Thirteen acylated flavonoid glycosides, 1-13, including eleven new congeners, 3-13, were isolated from the aerial parts of Pritzelago alpina (Brassicaceae) by a combination of column chromatography on Sephadex LH-20, and preparative and semi-preparative HPLC. The structures were established by extensive NMR and MS experiments in combination with acid hydrolysis and sugar analysis by GC/MS. The new compounds were shown to be kaempferol and quercetin glycosides acylated for most of them by a branched short chain fatty acid or a hydroxycinnamic acid residue on the sugar portion. As shown by a HPLC-DAD analysis of a MeOH extract, these compounds are the main phenolic constituents in the aerial parts of the plant.
authors.affiliation: University of Basel, Division of Pharmaceutical Biology, Klingelbergstrasse 50, CH-4056 Basel, (phone: +41-61-2671534; fax: +41-61-2671474).
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Corradi
authors.affiliation: University of Basel, Division of Pharmaceutical Biology, Klingelbergstrasse 50, CH-4056 Basel, (phone: +41-61-2671534; fax: +41-61-2671474).
authors.forename: Maria
authors.initials: M
authors.lastname: De Mieri
authors.affiliation: University of Basel, Division of Pharmaceutical Biology, Klingelbergstrasse 50, CH-4056 Basel, (phone: +41-61-2671534; fax: +41-61-2671474).
authors.forename: Larissa
authors.initials: L
authors.lastname: Cadisch
authors.affiliation: University of Basel, Division of Pharmaceutical Biology, Klingelbergstrasse 50, CH-4056 Basel, (phone: +41-61-2671534; fax: +41-61-2671474).
authors.forename: Christian
authors.initials: C
authors.lastname: Abbet
authors.affiliation: University of Basel, Division of Pharmaceutical Biology, Klingelbergstrasse 50, CH-4056 Basel, (phone: +41-61-2671534; fax: +41-61-2671474).
authors.forename: Matthias
authors.initials: M
authors.lastname: Hamburger
authors.affiliation: University of Basel, Division of Pharmaceutical Biology, Klingelbergstrasse 50, CH-4056 Basel, (phone: +41-61-2671534; fax: +41-61-2671474). olivier.potterat@unibas.ch.
authors.forename: Olivier
authors.initials: O
authors.lastname: Potterat
mesh_terms: D000215:Acylation; D019607:Brassicaceae / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D044948:Flavonols / Q000737:chemistry* / Q000302:isolation & purification; D008401:Gas Chromatography-Mass Spectrometry; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D044949:Kaempferols / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry; D010945:Plants, Edible / Q000737:chemistry; D011794:Quercetin / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D044948:Flavonols; D006027:Glycosides; D044949:Kaempferols; D010636:Phenols; D010936:Plant Extracts; C006552:kaempferol; D011794:Quercetin
keywords: Acylated flavonol glycosides; Hutchinsia alpina; Phenolic profile; Pritzelago alpina