title: Interventional stem cell therapy.
abstract: The ability to deliver cells in appropriate doses to their targeted site of action is a well-known obstacle to optimising stem cell therapy. Systemic administration of cells results in pulmonary "trapping," which significantly decreases the number of available circulating cells to impact underlying disorders. Directed delivery of stem cells in interventional radiology may provide an additional option for bypassing the lungs, as well as introduce novel potential avenues for decreasing doses required to effect cellular therapy, efficiently obtain local paracrine effects, and/or to simplify targeting strategies.
authors.affiliation: Division of Interventional Radiology and Image Guided Medicine, Emory University School of Medicine, 1364 Clifton Rd NE, Suite AG05, Atlanta, GA 30322, USA. Electronic address: John.david.prologo@emory.edu.
authors.forename: J D
authors.initials: JD
authors.lastname: Prologo
authors.affiliation: Division of Interventional Radiology and Image Guided Medicine, Emory University School of Medicine, 1364 Clifton Rd NE, Suite AG05, Atlanta, GA 30322, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hawkins
authors.affiliation: Division of Interventional Radiology and Image Guided Medicine, Emory University School of Medicine, 1364 Clifton Rd NE, Suite AG05, Atlanta, GA 30322, USA.
authors.forename: C
authors.initials: C
authors.lastname: Gilliland
authors.affiliation: Department of Hematology and Oncology, Emory University School of Medicine, Winship Cancer Institute, 1365B Clifton Rd NE, Suite B506, Atlanta, GA 30322, USA.
authors.forename: R
authors.initials: R
authors.lastname: Chinnadurai
authors.affiliation: Division of Musculoskeletal Radiology, Emory University School of Medicine, 1364 Clifton Rd NE, Suite AG05, Atlanta, GA 30322, USA.
authors.forename: P
authors.initials: P
authors.lastname: Harkey
authors.affiliation: Department of Surgery, Emory University School of Medicine, 1364 Clifton Rd NE, Suite H100, Atlanta, GA 30322, USA.
authors.forename: T
authors.initials: T
authors.lastname: Chadid
authors.affiliation: Department of Radiology, Case Western Reserve University College of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Lee
authors.affiliation: Department of Surgery, Emory University School of Medicine, 1364 Clifton Rd NE, Suite H100, Atlanta, GA 30322, USA; Department of Surgical and Research Services, Atlanta Veterans Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA.
authors.forename: Luke
authors.initials: L
authors.lastname: Brewster
mesh_terms: D006801:Humans; D015642:Radiology, Interventional; D033581:Stem Cell Transplantation