title: Beneficial effects of quercetin-iron complexes on serum and tissue lipids and redox status in obese rats.
abstract: Obesity is characterized by iron deficiency, carbohydrate and fat alterations as well as oxidative stress. Iron status monitoring is recommended because of the conventional oral iron preparations that frequently exacerbate the already present oxidative stress. Iron complexation by natural antioxidants can be exploited. We herein investigated the metabolic effects of quercetin (25 mg/kg/day), iron (2.5 mg Fe/kg/day) or quercetin-iron complexes (molar ratio 5:1; 25 mg/2.5 mg/kg/day) in animal models of obesity. Our results emphasized that obese rats displayed metabolic alterations that were worsened by iron supplementation. In contrast, quercetin used alone or as iron complex clearly prevented adipose fat accumulation and alleviated the hyperglycemia, hyperlipidemia, liver steatosis and oxidative stress. In addition, it induced a modulation of lipase activities in obese rats. Interestingly, quercetin-iron complexes showed enhanced beneficial effects such as a corrected iron deficiency in obese rats when compared to quercetin alone. In conclusion, antianemic, hypoglycemic, hypolipidemic and antioxidative effects of the quercetin-iron complexes shed a light on their beneficial use against obesity-related metabolic alterations.
authors.affiliation: Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria.
authors.forename: Asmahan
authors.initials: A
authors.lastname: Imessaoudene
authors.affiliation: Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria. Electronic address: hafidamerzouk_2@hotmail.com.
authors.forename: Hafida
authors.initials: H
authors.lastname: Merzouk
authors.affiliation: Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria.
authors.forename: Farid
authors.initials: F
authors.lastname: Berroukeche
authors.affiliation: Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria.
authors.forename: Nassima
authors.initials: N
authors.lastname: Mokhtari
authors.affiliation: Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria.
authors.forename: Bachir
authors.initials: B
authors.lastname: Bensenane
authors.affiliation: Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria.
authors.forename: Sabri
authors.initials: S
authors.lastname: Cherrak
authors.affiliation: Department of Technical Sciences, Faculty of Engineering, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria.
authors.forename: Sid Ahmed
authors.initials: SA
authors.lastname: Merzouk
authors.affiliation: Laboratory of Bioorganic and Medicinal Chemistry, UMR 7509 CNRS - University of Strasbourg, ECPM, 25 rue Becquerel Street, 67087 Strasbourg, Cedex 2, France.
authors.forename: Mourad
authors.initials: M
authors.lastname: Elhabiri
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007501:Iron / Q000737:chemistry / Q000494:pharmacology*; D008055:Lipids / Q000032:analysis / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008055:Lipids; D011794:Quercetin; D007501:Iron
keywords: Adipose tissue; Iron; Liver; Metabolism; Muscle; Obesity; Quercetin