title: Phytochemical Screening, Antidepressant and Analgesic Effects of Aqueous Extract of Anethum graveolens L. From Southeast of Morocco.
abstract: This study aims to investigate the antidepressant and analgesic properties of the aqueous extract of Anethum graveolens L. from South of Morocco (Rissani-Errachidia region). Extract of plant is obtained by aqueous decoction and administered to Wistar rats orally. The extract has a significant antidepressant and analgesic effects compared with the drug references (sertraline and tramadol) without any adverse effects. The dose of 250 mg/kg, body weight shows the best antidepressant and analgesic effects than 1 g/kg, body weight. Phytochemical study of the aqueous extract of the plant has to show its highlight in polyphenols, flavonoids, and tannins.
authors.affiliation: 1LPAMSN, Department of Valorization and Industrial Application, National Institute of Medicinal and Aromatic Plants, LAMEC, Faculty of Sciences Dhar El Mehraz, Sidi Mohamed Ben Abdellah University (USMBA), Fez, Morocco; 2LPAMSN, Department of Valorization and Industrial Application, National Institute of Medicinal and Aromatic Plants, Sidi Mohamed Ben Abdellah University (USMBA), Fez, Morocco; and 3Faculty of Sciences and Technics, Sidi Mohamed Ben Abdellah University (USMBA), Fez, Morocco.
authors.forename: Latifa
authors.initials: L
authors.lastname: El Mansouri
authors.forename: Dalila
authors.initials: D
authors.lastname: Bousta
authors.forename: Amal
authors.initials: A
authors.lastname: El Youbi-El Hamsas
authors.forename: Smahane
authors.initials: S
authors.lastname: Boukhira
authors.forename: Hassane
authors.initials: H
authors.lastname: Akdime
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D028524:Anethum graveolens; D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids; D008297:Male; D009018:Morocco; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D020280:Sertraline / Q000494:pharmacology; D013634:Tannins; D014147:Tramadol / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000928:Antidepressive Agents; D005419:Flavonoids; D010936:Plant Extracts; D059808:Polyphenols; D013634:Tannins; D014147:Tramadol; D020280:Sertraline