title: Interleukin-17 acts as double-edged sword in anti-tumor immunity and tumorigenesis.
abstract: Interleukin-17 (IL-17), a proinflammatory cytokine, mainly produced by Th17 cells, participates in both innate and adaptive immune responses and is involved in various diseases, including infectious diseases, autoimmune disorders and cancer. Emerging evidence indicates that IL-17 not only has an oncogenic role in tumorigenesis by regulating tumor angiogenesis and enhancing tumor immune evasion but also exerts anti-tumor functions by enhancing natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) activation and through the recruitment of neutrophils, NK cells and CD4+and CD8+T cells to tumor tissue. In this review, we provide an overview on the basic biology of IL-17 and recent findings regarding its enigmatic double-edged features in tumorigenesis, with special attention to the roles of IL-17 produced by tumor cells interacting with other factors in the tumor microenvironment.
authors.affiliation: Department of Respiratory Medicine, Taihe Hospital, Hubei University of Medicine, No. 32, South Renmin Road, Shiyan 44200, Hubei Province, China. Electronic address: xinqiantj@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Qian
authors.affiliation: Rush University Cancer Center, Chicago, IL 60612, USA. Electronic address: HANKUI_CHEN@rush.edu.
authors.forename: Hankui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, Taihe Hospital, Hubei University of Medicine, No. 32, South Renmin Road, Shiyan 44200, Hubei Province, China. Electronic address: Wu-8921324@qq.com.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wu
authors.affiliation: Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430064, China. Electronic address: 232836909@qq.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, PR China. Electronic address: huangqi66@126.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Department of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, PR China. Electronic address: whuhjy@126.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Jin
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D020381:Interleukin-17 / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology* / Q000473:pathology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology* / Q000473:pathology; D059016:Tumor Microenvironment / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: Angiogenesis; Cytokine; Interleukin (IL)-17; Tumor immunity; Tumorigenesis