title: Adder and a coarse-grained approach to cell size homeostasis in bacteria.
abstract: Cell size control and homeostasis is a long-standing subject in biology. Recent experimental work provides extensive evidence for a simple, quantitative size homeostasis principle coined adder (as opposed to sizer or timer). The adder principle provides unexpected insights into how bacteria maintain their size without employing a feedback mechanism. We review the genesis of adder and recent cell size homeostasis study on evolutionarily divergent bacterial organisms and beyond. We propose new coarse-grained approaches to understand the underlying mechanisms of cell size control at the whole cell level.
authors.affiliation: UCSD Physics and Molecular Biology, 9500 Gilman Dr., La Jolla, CA 92093, United States.
authors.forename: John T
authors.initials: JT
authors.lastname: Sauls
authors.affiliation: UCSD Physics and Molecular Biology, 9500 Gilman Dr., La Jolla, CA 92093, United States.
authors.forename: Dongyang
authors.initials: D
authors.lastname: Li
authors.affiliation: UCSD Physics and Molecular Biology, 9500 Gilman Dr., La Jolla, CA 92093, United States. Electronic address: suckjoon.jun@gmail.com.
authors.forename: Suckjoon
authors.initials: S
authors.lastname: Jun
mesh_terms: D001419:Bacteria; D005075:Biological Evolution; D006706:Homeostasis