title: Acute intermittent porphyria precipitated by atazanavir/ritonavir.
abstract: Porphyrias are a group of metabolic disorders that are relatively uncommon and underdiagnosed. Although the association between HIV infection and antiretrovirals with porphyria cutanea tarda is well established, there are fewer data linking HIV and the acute hepatic porphyrias. We report the first case of acute intermittent porphyria precipitated by the drugs atazanavir and ritonavir, presenting with unexplained abdominal pain.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY, USA sbharti@nshs.edu.
authors.forename: Sheena
authors.initials: S
authors.lastname: Bharti
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY, USA.
authors.forename: Prashant
authors.initials: P
authors.lastname: Malhotra
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY, USA.
authors.forename: Bruce
authors.initials: B
authors.lastname: Hirsch
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000069446:Atazanavir Sulfate / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D017118:Porphyria, Acute Intermittent / Q000139:chemically induced* / Q000175:diagnosis; D011480:Protease Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D019438:Ritonavir / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D011480:Protease Inhibitors; D000069446:Atazanavir Sulfate; D019438:Ritonavir
keywords: AIDS; HIV; acute porphyria; antiretrovirals and porphyria; atazanavir and porphyria; porphyria; protease inhibitors; ritonavir and porphyria