title: Selectively fluorinated cyclohexane building blocks: Derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane.
abstract: Palladium catalysed carbonylation reactions using the meta- and para-iodo derivatives of all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane (4) are illustrated as the start point for a variety of functional group interconversions. The resultant benzaldehyde and benzoic acids offer novel building blocks for further derivatisation and facilitate the incorporation of the facially polarised all-cis-1,2,4,5-tetrafluorocyclohexane motif into more advanced molecular scaffolds.
authors.affiliation: School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK; Department of Chemistry, Faculty of Science, P.B 426 Ibrahimia, Alexandria University, Egypt.
authors.forename: Mohammed Salah
authors.initials: MS
authors.lastname: Ayoup
authors.affiliation: School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK.
authors.forename: David B
authors.initials: DB
authors.lastname: Cordes
authors.affiliation: School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK.
authors.forename: Alexandra M Z
authors.initials: AM
authors.lastname: Slawin
authors.affiliation: School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK.
authors.forename: David
authors.initials: D
authors.lastname: O'Hagan
keywords: cyclohexane carbonylation; fluorine containing building blocks: organofluorine chemistry