title: A simple aptamer-functionalized gold nanorods based biosensor for the sensitive detection of MCF-7 breast cancer cells.
abstract: Herein, we describe a novel approach for the rapid diagnosis of human breast carcinoma MCF-7 cells with a detection limit of 100 cells mL(-1). In our strategy, the MCF-7 cells are specially recognized by mucin 1 protein (MUC-1) aptamer-functionalized gold nanorods (GNRs) through specific interactions, whose signals are simply read out by its unique localized surface plasmon resonance (LSPR) spectra.
authors.affiliation: Beijing Institute of Transfusion Medicine, Beijing Key Laboratory of Blood Safety and Supply Technologies, Beijing 100850, China. lszhan91@yahoo.com lovechina1980@163.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Yulong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Man
authors.initials: M
authors.lastname: Zhao
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Zhou
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.forename: Huizhong
authors.initials: H
authors.lastname: Wang
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wang
authors.forename: Linsheng
authors.initials: L
authors.lastname: Zhan
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D014408:Biomarkers, Tumor / Q000032:analysis; D015374:Biosensing Techniques; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D006046:Gold / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry*; D018396:Mucin-1 / Q000032:analysis; D020349:Surface Plasmon Resonance
chemical_list: D052157:Aptamers, Nucleotide; D014408:Biomarkers, Tumor; C060192:MUC1 protein, human; D018396:Mucin-1; D006046:Gold