title: Association between CYP1A1 2454A > G polymorphism and colorectal cancer risk: A meta-analysis.
abstract: BACKGROUND
  The aim of our study was to assess the association of CYP1A1 2454A > G polymorphism and colorectal cancer (CRC) risk.
  
  
  METHODS
  Electronic databases, including PubMed, MEDLINE Springer, Elsevier Science Direct, Cochrane Library, and Google Scholar were searched for relevant trials until December 2013. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. Subgroup analyses were conducted based on geographical region and size of the study samples.
  
  
  RESULTS
  Thirteen eligible studies were included in this meta-analysis with 3490 cases and 4076 controls. There were significant associations under the overall ORs for G-allele comparison (G vs. A, pooled OR 1.29, 95% CI 1.03-1.61, P = 0.03), GG versus AA comparison (pooled OR 1.50, 95% CI 1.17-1.91, P < 0.01), recessive model (GG vs. GA + AA, pooled OR 1.52, 95% CI 1.20-1.94, P < 0.01) between CYP1A1 2454A > G polymorphism and CRC risk. Subgroup analyses stratified by geographical region demonstrated an association in Asia and Europe, but not in America.
  
  
  CONCLUSIONS
  This meta-analysis suggests that CYP1A1 2454A > G polymorphism might be associated with susceptibility of CRC and the allele G might increase the CRC risk in Asia and Europe.
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Oncology, General Hospital of Liaohe Oil Field, Xinglongtai, Panjin City 124010, Liaoning Province, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wei
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1