title: The autologous platelet rich fibrin: A novel approach in osseous regeneration after cystic enucleation: A pilot study.
abstract: BACKGROUND
  The platelet rich fibrin (PRF) is second generation platelet concentrate that has been widely used and researched for stimulation and acceleration of soft tissue and osseous healing. Its continuous delivery of growth factors and proteins mimic the need of physiological wound healing and regenerative tissue processes.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the efficacy of PRF in osseous regeneration after enucleation of cystic lesions. The objectives of this study were: (1) To evaluate osseous regeneration radiographically with the use of PRF in intrabony defects after cystic enucleation. (2) To evaluate the degree of bone density in intrabony defects with the use of PRF postoperatively after 1 st , 3 rd , and 6 th months.
  
  
  METHODS
  10 cases of cystic lesions were treated using PRF after cystic enucleation. Follow-up radiographs (orthopantomogram) were taken 1 st , 3 rd , and 6 th months postoperatively. Bone density was measured with grayscale histogram using Adobe Photoshop 7.0 software.
  
  
  RESULTS
  The subsequent follow-up examinations revealed progressive, predictable, and significant radiographic osseous regeneration.
  
  
  CONCLUSIONS
  The use of PRF in management of cystic lesions seems to be a novel therapeutic approach promoting faster osseous regeneration within 6 months postoperatively however further study is required with larger sample size and with a control group.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur, Maharashtra, India.
authors.forename: Vikas Sukhadeo
authors.initials: VS
authors.lastname: Meshram
authors.forename: Pravin Narendra
authors.initials: PN
authors.lastname: Lambade
authors.forename: Priyatama Vikas
authors.initials: PV
authors.lastname: Meshram
authors.forename: Aishwarya
authors.initials: A
authors.lastname: Kadu
authors.forename: Manish Sevalal
authors.initials: MS
authors.lastname: Tiwari
mesh_terms: D000328:Adult; D001792:Blood Platelets; D001861:Bone Regeneration / Q000502:physiology*; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D006801:Humans; D007570:Jaw Cysts / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011862:Radiography, Panoramic; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
chemical_list: D005337:Fibrin