title: Impact of Systemic Inflammation on the Progression of Gestational Diabetes Mellitus.
abstract: With increasing rates of obesity and new diagnostic criteria for gestational diabetes mellitus (GDM), the overall prevalence of GDM is increasing worldwide. Women with GDM have an increased risk of maternal and fetal complications during pregnancy as well as long-term risks including higher prevalence of type 2 diabetes mellitus and cardiovascular disease. In recent years, the role of immune activation and inflammation in the pathogenesis of GDM has gained increasing attention. This monograph explores the current state of the literature as regards the expression of markers of inflammation in the maternal circulation, placenta, and adipose tissue of women with GDM.
authors.affiliation: Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, 0027, Oslo, Norway. tove.lekva@rr-research.no.|Mother Infant Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA, 02116, USA. tove.lekva@rr-research.no.
authors.forename: Tove
authors.initials: T
authors.lastname: Lekva
authors.affiliation: Mother Infant Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA, 02116, USA. enorwitz@tuftsmedicalcenter.org.|Department of Obstetrics & Gynecology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA. enorwitz@tuftsmedicalcenter.org.
authors.forename: Errol R
authors.initials: ER
authors.lastname: Norwitz
authors.affiliation: Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, 0027, Oslo, Norway. pal.aukrust@ous-hf.no.|Faculty of Medicine, University of Oslo, Oslo, Norway. pal.aukrust@ous-hf.no.|Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Oslo, Norway. pal.aukrust@ous-hf.no.
authors.forename: Pål
authors.initials: P
authors.lastname: Aukrust
authors.affiliation: Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, 0027, Oslo, Norway. thor.ueland@medisin.uio.no.|Faculty of Medicine, University of Oslo, Oslo, Norway. thor.ueland@medisin.uio.no.
authors.forename: Thor
authors.initials: T
authors.lastname: Ueland
mesh_terms: D000273:Adipose Tissue / Q000276:immunology / Q000378:metabolism; D000818:Animals; D016640:Diabetes, Gestational / Q000276:immunology* / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D009765:Obesity / Q000150:complications; D010920:Placenta / Q000276:immunology / Q000378:metabolism; D011247:Pregnancy
keywords: Adipose tissue; GDM; Placenta; Systemic inflammation