title: [Rapid determination of 8 urinary carbamate pesticides by liquid chromatography-tandem mass spectrometry].
abstract: OBJECTIVE
  To establish a method for simultaneously determining the urinary concentrations of 8 carbamate pesticides.
  
  
  METHODS
  After being purified by acetonitrile precipitation, urine samples were transferred to a liquid chromatography-tandem mass spectrometry system, and the concentrations of 8 carbamate pesticides were determined by external standard method. A C18 column was used for ultra-high-performance liquid chromatography; methanol/ammonium acetate solution was used as the mobile phase for gradient elution; the mass spectrometer was operated in a multi-reaction monitoring mode.
  
  
  RESULTS
  The calibration curves were linear when the urinary concentrations of these carbamate pesticides were 20~800 µg/L, and the recovery rates were 61.0%~121% at spiked levels of 20, 200 and 800 µg/L, with a relative standard deviation of 1.7%~5.5%.
  
  
  CONCLUSIONS
  This determination method meets the Guide for establishing occupational health standards-part 5: Determination methods of chemicals in biological materials, and can be used for simultaneous determination of 8 carbamate pesticides in the urine of poisoning patients.
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
authors.forename: Hualiang
authors.initials: H
authors.lastname: Liu
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China; E-mail: lhl-1@163.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhu
mesh_terms: D002138:Calibration; D002219:Carbamates / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010575:Pesticides / Q000652:urine*; D053719:Tandem Mass Spectrometry
chemical_list: D002219:Carbamates; D010575:Pesticides