title: The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer.
abstract: OBJECTIVE
  The precise role of phosphorylated heat shock protein (HSP) 27 (p-HSP27) in pancreatic cancer remains to be elucidated. The aim of this study was to investigate whether the expression of p-HSP27 predicts the prognosis of patients with pancreatic cancer.
  
  
  METHODS
  We retrospectively assessed 49 biopsied pancreatic cancer tissue samples that were obtained prior to the treatment with gemcitabine. The correlations between p-HSP27 and the clinicopathological characteristics were analyzed.
  
  
  RESULTS
  p-HSP27 was not correlated with the response to chemotherapy or histological type. However, the median survival time was significantly longer in the patients with high p-HSP27 (275 days, n = 18) than those with low p-HSP27 (205 days, n = 31) (P = 0.0158). A multivariate Cox proportional hazards regression analysis revealed that low p-HSP27 predicted a worse prognosis.
  
  
  CONCLUSIONS
  Higher p-HSP27 expression before chemotherapy was correlated with better survival, indicating that p-HSP27 expression could be used to predict the prognosis of pancreatic cancer.
authors.affiliation: Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Okuno
authors.affiliation: Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yasuda
authors.affiliation: Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Adachi
authors.affiliation: Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakashima
authors.affiliation: Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Kawaguchi
authors.affiliation: Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.
authors.forename: Shinpei
authors.initials: S
authors.lastname: Doi
authors.affiliation: Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Iwashita
authors.affiliation: Department of Pathology, Osaka Medical College, Takatsuki, Osaka, 569-8686, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Hirose
authors.affiliation: Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Kozawa
authors.affiliation: Department of Pathology and Oncology, Graduate School of Medical Science, University of the Ryukyus, Nishihara-cho, Okinawa, 903-0215, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Yoshimi
authors.affiliation: Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.
authors.forename: Masahito
authors.initials: M
authors.lastname: Shimizu
authors.affiliation: Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.
authors.forename: Hisataka
authors.initials: H
authors.lastname: Moriwaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D055551:HSP27 Heat-Shock Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D010766:Phosphorylation; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D014408:Biomarkers, Tumor; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D003841:Deoxycytidine; D000093542:Gemcitabine
keywords: HSP27; pancreatic cancer; phosphorylation; prognosis