title: Characteristics of bacterial vaginosis infection in cervical lesions with high risk human papillomavirus infection.
abstract: High risk human papillomavirus (HPV) infection is the major cause of cervical cancer. Bacterial vaginosis (BV) is considered as the most prevalent vaginal imbalance affecting women of reproductive age. However, the relationship between HPV and BV infection is unclear. This study aimed to assess the prevalence of human papillomavirus (HPV) infection combined with bacterial vaginosis (BV) infection in Shanghai suburbs and evaluate associations between bacterial vaginosis with HPV infection, cervical intraepithelial neoplasia (CIN) and cervical cancer.
  
  
  METHODS
  From October 1, 2009 to October 31, 2013, a total number of 3502 women who visited Fengxian Hospital, Southern Medical University were enrolled in this study. All participants gave informed consent and agreed to HPV, BV, chlamydia, mycoplasma and thinprepcytologic test (TCT). In addition, all women took histopathologic examination under colposcopy. Statistical analyses were done using SPSS 17.0 for windows (IBM). In present study the overall BV-positive rate was 9.25%. The top three high risk HPV types were listed as follows (in descending order): HPV16, 52, 58. Moreover, our data showed BV infection tended to occur in the HPV positive women, HPV infection also tended to occur in the BV positive women. Most of the women who present HPV with BV infection were younger than 30 years old. We also found that CIN and cervical cancer occurred mainly in HPV/BV positive and HPV with BV positive group. BV infection and HPV infection may haveconsistency or synergies. HPV with BV infection may increase the incidence of CIN and cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University Shanghai 201499, P. R. China.
authors.forename: Huan
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Obstetrics and Gynecology, Changzhou NO. 2 People's Hospital Changzhou 213003, Jiangsu, P. R. China.
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Jiang
authors.affiliation: Medical College of Nanchang University Nanchang 330000, Jiangxi, P. R. China.
authors.forename: Xiao-Dan
authors.initials: XD
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University Shanghai 201499, P. R. China.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Hou
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University Shanghai 201499, P. R. China.
authors.forename: Zhen-Hong
authors.initials: ZH
authors.lastname: Wei
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University Shanghai 200011, P. R. China.
authors.forename: Jia-Qi
authors.initials: JQ
authors.lastname: Lu
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University Shanghai 200011, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University Shanghai 201499, P. R. China.
authors.forename: Guang-Xu
authors.initials: GX
authors.lastname: Xu
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University Shanghai 201499, P. R. China.
authors.forename: Yuan-Ping
authors.initials: YP
authors.lastname: Chen
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan UniversityShanghai 200011, P. R. China; Changzhou Maternal and Child Health Care HospitalChangzhou 213003, Jiangsu, P. R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Changzhou Maternal and Child Health Care Hospital Changzhou 213003, Jiangsu, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University Shanghai 201499, P. R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University Shanghai 201499, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
keywords: Bacterial vaginosis infection; HPV types; cervical lesion