title: Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature.
abstract: Gamma heavy chain disease (gHCD) is a rare lymphoproliferative disorder characterized by the production of a truncated immunoglobulin heavy chain. Although some cases of gHCD are concurrent with other lymphoid neoplasms, few have been reported. We herein present the case of a 73-year-old woman with gHCD and T-cell large granular lymphocytic leukemia. A multiparameter flow cytometry analysis revealed neoplastic cells that were positive for CD28, a marker of T-cell activation, the anti-apoptotic antigen of neoplastic plasma cells, CD38 and CD45. The results of this multiparameter flow cytometry analysis may contribute to furthering the understanding of the clinicopathological features of gHCD.
authors.affiliation: Hematology Division, National Hospital Organization Disaster Medical Center, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Iijima
authors.forename: Naohiro
authors.initials: N
authors.lastname: Sekiguchi
authors.forename: Akihisa
authors.initials: A
authors.lastname: Nagata
authors.forename: Miyuki
authors.initials: M
authors.lastname: Wagatsuma
authors.forename: Kiyoe
authors.initials: K
authors.lastname: Midorikawa
authors.forename: Miwa
authors.initials: M
authors.lastname: Kurimoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Noto
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Yamada
authors.forename: Naoki
authors.initials: N
authors.lastname: Takezako
mesh_terms: D000368:Aged; D000740:Anemia / Q000209:etiology / Q000276:immunology*; D020732:Cytogenetic Analysis; D005221:Fatigue / Q000209:etiology / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006362:Heavy Chain Disease / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains / Q000097:blood / Q000378:metabolism*; D054066:Leukemia, Large Granular Lymphocytic / Q000150:complications / Q000276:immunology / Q000473:pathology*; D008214:Lymphocytes / Q000378:metabolism*
chemical_list: D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains