title: [Clinical Analysis of Drug-induced Liver Injury Caused by Polygonum multiflorum and its Preparations].
abstract: OBJECTIVE
  To analyze hepatotoxicity of Polygonum multiflorum and clinical character- istics of drug-induced liver injury (DILI) caused by Polygonum multiflorum and its preparations.
  
  
  METHODS
  A retrospective study was performed in 158 patients treated at 302 Military Hospital between January 2009 and January 2014. All of them had used Polygonum multiflorum and its preparations before the onset of DILI, and their clinical characteristics and prognoses were analyzed.
  
  
  RESULTS
  Of the 158 DILI patients who used Polygonum multiflorum or its preparations, 92 (58.2%) combined with Western medicine or Chinese herbal preparations without Polygonum multiflorum; 66 patients (41.8%) used Polygonum mult florum and its preparations alone. In 66 DILI patients induced by Polygonum multiflorum or its preparations alone, 51 cases (77.3%) were induced by Polygonum multiflorum compounds and 22.7% by single Po- lygonum multiflorum; 4 cases (6.1%) were caused by crude Polygonum multiflorum and 62 (93.9%) by processed Polygonum multiflorum and its preparations. Clinical injury patterns were hepatocellular 92.4% (61 cases), cholestatic 1.5% (1 case), and mixed 6.1% (4 cases). Pathological examination was per- formed by liver biopsy in 32 cases (48.15%), manifested as hepatocellular degeneration and necrosis, fibroplasia, Kupffer cells with pigment granule, and a large number of eosinophil infiltration, were ob- served. Four patients were developed into liver failure, 4 into cirrhosis, and 1 died.
  
  
  CONCLUSIONS
  Polygo- num multiflorum and its preparations could induce DILI, but clinical diagnosis of Polygonum multiflorum induced hepatotoxicity should be cautious.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhu
authors.forename: Shu-hong
authors.initials: SH
authors.lastname: Liu
authors.forename: Jia-bo
authors.initials: JB
authors.lastname: Wang
authors.forename: Hai-bo
authors.initials: HB
authors.lastname: Song
authors.forename: Yong-gang
authors.initials: YG
authors.lastname: Li
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: He
authors.forename: Xiao
authors.initials: X
authors.lastname: Ma
authors.forename: Zhong-xia
authors.initials: ZX
authors.lastname: Wang
authors.lastname: Wang-Li-ping
authors.forename: Kun
authors.initials: K
authors.lastname: Zhou
authors.forename: Yun-feng
authors.initials: YF
authors.lastname: Bai
authors.forename: Zheng-sheng
authors.initials: ZS
authors.lastname: Zou
authors.forename: Xiao-he
authors.initials: XH
authors.lastname: Xiao
mesh_terms: D044466:Asian People; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D002779:Cholestasis; D004365:Drugs, Chinese Herbal / Q000009:adverse effects; D000068676:Fallopia multiflora; D006801:Humans; D008103:Liver Cirrhosis; D017093:Liver Failure; D028321:Plant Preparations / Q000009:adverse effects*; D028502:Polygonum; D012189:Retrospective Studies
chemical_list: D004365:Drugs, Chinese Herbal; D028321:Plant Preparations