title: [Effectsof the time interval and the endocrine therapy on the prognosis and consistency of the biological indicatorsin patients with bilateral primary breast cancer].
abstract: OBJECTIVE
  The study aimed to discuss whether the time interval between bilateral primary breast cancers (BPBC)and the endocrine therapy status after thefirst primary cancer could influence the prognosis and consistency of the biological indicators.
  
  
  METHODS
  Clinical data of 133 patients with BPBC in cancer institute and hospital of Tianjin medical university from January 2005 to December 2008 were retrospectively analyzed. The patients were divided into two groups according to the time interval and the endocrine therapy. The consistency of hormone receptor and human epidermal growth factor receptor-2 (HER-2) expression between the bilateral tumors and the prognosis of BPBC in different groups were analyzed.
  
  
  RESULTS
  With the extension of time interval, the consistent rate of biological indicators between the bilateral tumorshas decreased.The consistent rate of estrogen receptor (ER)was higher than that of progestin hormone (PR) in each group. When the time interval was six or less months, ER and HER-2 had the consistency and correlation between the two primary cancers(P≤0.05). In patients who did not receiveendocrine therapyafter the first cancer, the consistent rates of the biological indicators were higher and ER had betterconsistency and correlation(P≤0.05). Time interval and endocrine therapy hadno effecton the overall survival of the patients.
  
  
  CONCLUSIONS
  With the extension of the time interval, the consistency of the biological indicators in BPBChas decreased.ER and HER-2 of the bilateral tumorshad a high similarity in patients whose time interval wasno more than 6 months.Endocrine therapy could also affect the consistency of the biological indicators.However, these two factors were not associated with prognosis in patients with BPBC.
authors.affiliation: Center of Breast Cancer, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China.
authors.forename: Haotian
authors.initials: H
authors.lastname: Wang
authors.forename: Jingjing
authors.initials: J
authors.lastname: Duan
authors.forename: Xinwei
authors.initials: X
authors.lastname: Hou
authors.forename: Beibei
authors.initials: B
authors.lastname: Ye
authors.forename: Xuchen
authors.initials: X
authors.lastname: Cao
mesh_terms: D001943:Breast Neoplasms; D004703:Endocrine System; D006801:Humans; D011379:Prognosis; D011960:Receptors, Estrogen; D012189:Retrospective Studies
chemical_list: D011960:Receptors, Estrogen