title: Pharmacological and neuroethological study of the acute and chronic effects of lamotrigine in the genetic audiogenic seizure hamster (GASH:Sal).
abstract: The present study aimed to investigate the behavioral and anticonvulsant effects of lamotrigine (LTG) on the genetic audiogenic seizure hamster (GASH:Sal), an animal model of audiogenic seizure that is in the validation process. To evaluate the efficiency of acute and chronic treatments with LTG, GASH:Sals were treated with LTG either acutely via intraperitoneal injection (5-20mg/kg) or chronically via oral administration (20-25mg/kg/day). Their behavior was assessed via neuroethological analysis, and the anticonvulsant effect of LTG was evaluated based on the appearance and the severity of seizures. The results showed that acute administration of LTG exerts an anticonvulsant effect at the lowest dose tested (5mg/kg) and that chronic oral LTG treatment exerts an anticonvulsant effect at a dose of 20-25mg/kg/day. Furthermore, LTG treatment induced a low rate of secondary adverse effects. This article is part of a Special Issue entitled "Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic".
authors.affiliation: Institute of Neurosciences of Castilla and León/IBSAL, University of Salamanca, Salamanca, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Barrera-Bailón
authors.affiliation: Physiology Department, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: J A C
authors.initials: JAC
authors.lastname: Oliveira
authors.affiliation: Institute of Neurosciences of Castilla and León/IBSAL, University of Salamanca, Salamanca, Spain; Department of Cell Biology and Pathology, School of Medicine, University of Salamanca, Salamanca, Spain.
authors.forename: D E
authors.initials: DE
authors.lastname: López
authors.affiliation: Animal Research Service, University of Salamanca, Salamanca, Spain.
authors.forename: L J
authors.initials: LJ
authors.lastname: Muñoz
authors.affiliation: Physiology Department, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil. Electronic address: ngcairas@fmrp.usp.br.
authors.forename: N
authors.initials: N
authors.lastname: Garcia-Cairasco
authors.affiliation: Institute of Neurosciences of Castilla and León/IBSAL, University of Salamanca, Salamanca, Spain; Department of Physiology and Pharmacology, School of Medicine, University of Salamanca, Salamanca, Spain. Electronic address: sanchoc@usal.es.
authors.forename: C
authors.initials: C
authors.lastname: Sancho
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D006224:Cricetinae; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D020195:Epilepsy, Reflex / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D005010:Ethology / Q000379:methods; D000077213:Lamotrigine; D008297:Male; D008647:Mesocricetus; D012640:Seizures / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D016896:Treatment Outcome; D014227:Triazines / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine
keywords: Antiepileptic drugs; Audiogenic seizures; Lamotrigine; Neuroethology; Pharmacokinetics