title: Cutaneous involvement in multiple myeloma (MM): A case series with clinicopathologic correlation.
abstract: BACKGROUND
  Disease-specific skin lesions are rare in patients with multiple myeloma (MM).
  
  
  OBJECTIVE
  We sought to further characterize the clinical and pathologic features of patients with cutaneous involvement with MM.
  
  
  METHODS
  We identified 13 patients with cutaneous lesions of MM.
  
  
  RESULTS
  Cutaneous lesions consisted of pink, red, and violaceous papules, nodules, and/or plaques that varied in size. Histopathology revealed atypical plasma cells with occasional plasmablastic features. MM had aggressive biologic features and was at an advanced stage in the majority of patients. Despite aggressive management, including chemotherapy and stem-cell transplantation, most patients died of progressive disease within a few months after the development of cutaneous lesions.
  
  
  CONCLUSIONS
  The study group was relatively small.
  
  
  CONCLUSIONS
  Cutaneous involvement with MM is associated with aggressive biologic behavior and short survival.
authors.affiliation: Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
authors.forename: Jozef
authors.initials: J
authors.lastname: Malysz
authors.affiliation: Department of Internal Medicine, Division of Hematology-Oncology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Talamo
authors.affiliation: Cancer Institute, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
authors.forename: Junjia
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Dermatology Unit, Myriad Genetics Laboratories Inc, Salt Lake City, Utah.
authors.forename: Loren E
authors.initials: LE
authors.lastname: Clarke
authors.affiliation: Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Bayerl
authors.affiliation: Department of Dermatology, Wayne State University and Pinkus Dermatopathology, Detroit, Michigan.
authors.forename: Liaqat
authors.initials: L
authors.lastname: Ali
authors.affiliation: Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania; Department of Dermatology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
authors.forename: Klaus F
authors.initials: KF
authors.lastname: Helm
authors.affiliation: Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania; Department of Dermatology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania. Electronic address: cchung1@hmc.psu.edu.
authors.forename: Catherine G
authors.initials: CG
authors.lastname: Chung
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D002423:Cause of Death; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D010950:Plasma Cells / Q000473:pathology*; D011379:Prognosis; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000401:mortality* / Q000503:physiopathology / Q000556:secondary*; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents
keywords: clinical settings; cutaneous plasma cell lesions; diagnostic algorithms; multiple myeloma