title: Comparative Study of Activities of a Diverse Set of Antimycobacterial Agents against Mycobacterium tuberculosis and Mycobacterium ulcerans.
abstract: A library of compounds covering a broad chemical space was selected from a tuberculosis drug development program and was screened in a whole-cell assay against Mycobacterium ulcerans, the causative agent of the necrotizing skin disease Buruli ulcer. While a number of potent antitubercular agents were only weakly active or inactive against M. ulcerans, five compounds showed high activity (90% inhibitory concentration [IC90], ≤1 μM), making screening of focused antitubercular libraries a good starting point for lead generation against M. ulcerans.
authors.affiliation: Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland nicole.scherr@unibas.ch.
authors.forename: Nicole
authors.initials: N
authors.lastname: Scherr
authors.affiliation: Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.
authors.forename: Gerd
authors.initials: G
authors.lastname: Pluschke
authors.affiliation: Department of Chemistry, iMED Infection, AstraZeneca India Pvt. Ltd., Hebbal, Bangalore, India.
authors.forename: Manoranjan
authors.initials: M
authors.lastname: Panda
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D019911:Mycobacterium ulcerans / Q000187:drug effects*; D011720:Pyrazoles / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology
chemical_list: D000995:Antitubercular Agents; D011720:Pyrazoles; D011743:Pyrimidines; D015363:Quinolones; D013844:Thiazoles; C000606692:pyrazolylpyrimidine