title: Environmental Exposure to Triclosan and Semen Quality.
abstract: Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether, TCS) is widely used in personal care, household, veterinary and industrial products. It was considered as a potential male reproductive toxicant in previous in vitro and in vivo studies. However, evidence from human studies is scarce. Our study aims to investigate the relationship between TCS exposure and semen quality. We measured urinary TCS concentrations in 471 men recruited from a male reproductive health clinic. TCS was detected in 96.7% of urine samples, with a median concentration of 0.97 ng (mg·creatinine)(-1) (interquartile range, 0.41-2.95 ng (mg·creatinine)(-1)). A multiple linear regression analysis showed a negative association between natural logarithm (Ln) transformed TCS concentration (Ln-TCS) and Ln transformed number of forward moving sperms (adjusted coefficient β = -0.17; 95% confidence interval (CI) (-0.32, -0.02). Furthermore, among those with the lowest tertile of TCS level, Ln-TCS was negatively associated with the number of forward moving sperms (β = -0.35; 95% CI (-0.68, -0.03)), percentage of sperms with normal morphology (β = -1.64; 95% CI (-3.05, -0.23)), as well as number of normal morphological sperms, sperm concentration and count. Our findings suggest that the adverse effect of TCS on semen quality is modest at the environment-relevant dose in humans. Further studies are needed to confirm our findings.
authors.affiliation: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. windy5490@163.com.|MOE and Shanghai Key Laboratory of Children's Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. windy5490@163.com.
authors.forename: Wenting
authors.initials: W
authors.lastname: Zhu
authors.affiliation: MOE and Shanghai Key Laboratory of Children's Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. haozhang18@foxmail.com.|Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai 200032, China. haozhang18@foxmail.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Science and Research, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China. tcl_sh@aliyun.com.
authors.forename: Chuanliang
authors.initials: C
authors.lastname: Tong
authors.affiliation: Department of Andrology, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China. philip_1981@hotmail.com.
authors.forename: Chong
authors.initials: C
authors.lastname: Xie
authors.affiliation: Department of Andrology, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China. fanyishi166@sina.com.
authors.forename: Guohua
authors.initials: G
authors.lastname: Fan
authors.affiliation: MOE and Shanghai Key Laboratory of Children's Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. zhaosha2012@126.com.
authors.forename: Shasha
authors.initials: S
authors.lastname: Zhao
authors.affiliation: MOE and Shanghai Key Laboratory of Children's Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. xiaogangrain@sina.com.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Yu
authors.affiliation: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. tianmiejp@163.com.|MOE and Shanghai Key Laboratory of Children's Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. tianmiejp@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.affiliation: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. junjimzhang@sina.com.|MOE and Shanghai Key Laboratory of Children's Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. junjimzhang@sina.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000009:adverse effects / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D052244:Endocrine Disruptors / Q000009:adverse effects* / Q000378:metabolism; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D060728:Reproductive Health; D055101:Semen Analysis; D013076:Sperm Count; D013094:Spermatozoa / Q000187:drug effects*; D014260:Triclosan / Q000009:adverse effects / Q000378:metabolism*
chemical_list: D000891:Anti-Infective Agents, Local; D052244:Endocrine Disruptors; D014260:Triclosan
keywords: cross-sectional study; endocrine disruptor; semen quality; triclosan