title: Platelet Inhibitors.
abstract: Antithrombotic medications have become standard of care for management of acute coronary syndrome. Platelet adhesion, activation, and aggregation are essential components of platelet function; platelet-inhibiting medications interfere with these components and reduce incidence of thrombosis. Active bleeding is a contraindication for administration of platelet inhibitors. There is currently no reversal agent for platelet inhibitors, although platelet transfusion may be used to correct active bleeding after administration of platelet inhibitors.
authors.affiliation: Vanderbilt University School of Nursing, 461 21st Avenue South, 382 Frist Hall, Nashville, TN 37240, USA. Electronic address: megan.m.tyser@vanderbilt.edu.
authors.forename: Megan M
authors.initials: MM
authors.lastname: Shifrin
authors.affiliation: Vanderbilt University School of Nursing, 461 21st Avenue South, 366 Frist Hall, Nashville, TN 37240, USA. Electronic address: brian.widmar@vanderbilt.edu.
authors.forename: S Brian
authors.initials: SB
authors.lastname: Widmar
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy*; D001792:Blood Platelets / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006331:Heart Diseases / Q000188:drug therapy*; D006470:Hemorrhage / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy*
chemical_list: D010975:Platelet Aggregation Inhibitors
keywords: Acute coronary syndrome; Antiplatelet; Bleeding; Nursing; Platelets; Thrombosis