title: Multiple contrast type tests for the evaluation of animal carcinogenicity studies.
abstract: The Cochran-Armitage (CA) test is frequently used for testing the dose-response relationship in tumor incidence. This test is based on a weighted linear regression of proportions. It is well known that the CA test lacks power for nonlinear tumor outcomes. For general shape of outcomes, Hothorn and Bretz (2000) proposed a multiple contrast (MC) test. This test suggests the use of the maximum over several single contrasts, where each of them is chosen appropriately to cover a specific dose-response shape. In this work, two new test procedures are proposed and they are compared to the CA and MC tests using power.
authors.affiliation: a Division of Biometrics-6, Office of Biostatistics, Office of Translational Sciences , Center for Drug Evaluation and Research, US Food and Drug Administration , Silver Spring , Maryland , USA.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rahman
authors.affiliation: b Intermediate Office, Office of Biostatistics, Office of Translational Sciences , Center for Drug Evaluation and Research, US Food and Drug Administration , Silver Spring , Maryland , USA.
authors.forename: Ram
authors.initials: R
authors.lastname: Tiwari
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016014:Linear Models; D009369:Neoplasms / Q000139:chemically induced*
keywords: Animal carcinogenicity study; Cochran–Armitage test; dose–response relationship; multiple contrast test