title: Persistent organic pollutants and pregnancy complications.
abstract: We sought to investigate the relationship between maternal preconception exposures to persistent organic pollutants (POPs) and pregnancy complications, gestational diabetes (GDM) and gestational hypertension. Data from 258 (51%) women with human chorionic gonadotropin (hCG) confirmed pregnancies reaching ≥24weeks gestation, from a prospective cohort of 501 couples who discontinued contraception to attempt pregnancy, were analyzed. Preconception concentrations of 9 organochlorine pesticides (OCPs) and 10 polybrominated diphenyl ethers (PBDEs) were quantified in serum. In separate multiple logistic regression models of self-reported physician diagnosed outcomes: GDM (11%) and gestational hypertension (10%), chemicals were natural log-transformed and rescaled by their standard deviation (SD). Models were adjusted for serum lipids, and then adjusted for age, body mass index, race, and smoking. Models were additionally adjusted for the sum of the remaining POPs in each chemical class. Women's serum concentration of PBDE congener 153 (PBDE-153) was positively associated with an increased odds of GDM per SD increase in log-transformed concentration, for unadjusted (OR=1.36, 95%CI: 1.02-1.81), a priori adjusted (OR=1.38, 95% CI: 1.03-1.86) and with the sum of remaining PBDEs (OR=1.79, 95% CI: 1.18, 2.74) models. Our findings suggest that at environmentally relevant concentrations, maternal exposure to POPs prior to conception may contribute to increased chance of developing GDM.
authors.affiliation: Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: melissa.smarr@mail.nih.gov.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Smarr
authors.affiliation: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: katherine.grantz@nih.gov.
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Grantz
authors.affiliation: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: zhangcu@mail.nih.gov.
authors.forename: Cuilin
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: sundaramr2@mail.nih.gov.
authors.forename: Rajeshwari
authors.initials: R
authors.lastname: Sundaram
authors.affiliation: Glotech, Inc., Rockville, MD 20852, USA. Electronic address: bravas02@gmail.com.
authors.forename: José M
authors.initials: JM
authors.lastname: Maisog
authors.affiliation: Department of Environmental Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA. Electronic address: dbbarr@emory.edu.
authors.forename: Dana Boyd
authors.initials: DB
authors.lastname: Barr
authors.affiliation: Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: louisg@mail.nih.gov.
authors.forename: Germaine M Buck
authors.initials: GM
authors.lastname: Louis
mesh_terms: D000328:Adult; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000097:blood; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D010575:Pesticides / Q000097:blood; D011075:Polybrominated Biphenyls / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011446:Prospective Studies
chemical_list: D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D011075:Polybrominated Biphenyls; C478854:2,2',4,4',5,5'-hexabrominated diphenyl ether
keywords: Gestational diabetes mellitus; Hypertension; Organochlorine pesticides; Polybrominated diphenyl ethers; Preconception