title: Design of nanomaterial based systems for novel vaccine development.
abstract: With lower cell toxicity and higher specificity, novel vaccines have been greatly developed and applied to emerging infectious and chronic diseases. However, due to problems associated with low immunogenicity and complicated processing steps, the development of novel vaccines has been limited. With the rapid development of bio-technologies and material sciences, nanomaterials are playing essential roles in novel vaccine design. Incorporation of nanomaterials is expected to improve delivery efficiency, to increase immunogenicity, and to reduce the administration dosage. The purpose of this review is to discuss the employment of nanomaterials, including polymeric nanoparticles, liposomes, virus-like particles, peptide amphiphiles micelles, peptide nanofibers and microneedle arrays, in vaccine design. Compared to traditional methods, vaccines made from nanomaterials display many appealing benefits, including precise stimulation of immune responses, effective targeting to certain tissue or cells, and desirable biocompatibility. Current research suggests that nanomaterials may improve our approach to the design and delivery of novel vaccines.
authors.affiliation: College of Light Industry and Food Sciences, South China University of Technology, Uangzhou 510640, China. wenzhenliao@163.com wenzhenliao@outlook.com jyren@scut.edu.cn.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.forename: Michael
authors.initials: M
authors.lastname: Kirberger
authors.forename: Wenzhen
authors.initials: W
authors.lastname: Liao
authors.forename: Jiaoyan
authors.initials: J
authors.lastname: Ren
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D000071497:Immunogenicity, Vaccine; D008081:Liposomes / Q000737:chemistry; D008823:Micelles; D057139:Nanofibers / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D014612:Vaccines / Q000737:chemistry*; D058425:Vaccines, Virus-Like Particle / Q000737:chemistry
chemical_list: D008081:Liposomes; D008823:Micelles; D014612:Vaccines; D058425:Vaccines, Virus-Like Particle