title: Neuropathic Pain: Sensory Nerve Injury or Motor Nerve Injury?
abstract: Peripheral nerve injury often induces chronic neuropathic pain. Peripheral nerve is consisted of sensory fibers and motor fibers, it is questioned injury to which type of fibers is responsible for generation of neuropathic pain? Because neuropathic pain is sensory disorder, it is generally believed that the disease should be induced by injury to sensory fibers. In recent years, however, emergent evidence shows that motor fiber injury but not sensory fiber injury is necessary and sufficient for induction of neuropathic pain. Motor fiber injury leads to neuropathic pain by upregulating pro-inflammatory cytokines and brain-derived neurotrophic factor in pain pathway.
authors.affiliation: Pain Research Center and Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, 74 Zhongshan Rd. 2, Guangzhou, 510080, People's Republic of China. liuxg@mail.sysu.edu.cn.
authors.forename: Xian-Guo
authors.initials: XG
authors.lastname: Liu
authors.affiliation: Pain Research Center and Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, 74 Zhongshan Rd. 2, Guangzhou, 510080, People's Republic of China.
authors.forename: Rui-Ping
authors.initials: RP
authors.lastname: Pang
authors.affiliation: Pain Research Center and Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, 74 Zhongshan Rd. 2, Guangzhou, 510080, People's Republic of China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Zhou
authors.affiliation: Pain Research Center and Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, 74 Zhongshan Rd. 2, Guangzhou, 510080, People's Republic of China.
authors.forename: Xu-Hong
authors.initials: XH
authors.lastname: Wei
authors.affiliation: Pain Research Center and Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, 74 Zhongshan Rd. 2, Guangzhou, 510080, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zang
mesh_terms: D000200:Action Potentials; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis / Q000502:physiology; D059333:Central Nervous System Sensitization / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis / Q000502:physiology; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D006930:Hyperalgesia / Q000209:etiology / Q000503:physiopathology; D017774:Long-Term Potentiation; D017628:Microglia / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology*; D036421:Nerve Fibers, Unmyelinated / Q000502:physiology; D009437:Neuralgia / Q000209:etiology / Q000503:physiopathology*; D059225:Nociception / Q000502:physiology; D059348:Peripheral Nerve Injuries / Q000150:complications* / Q000503:physiopathology; D011984:Sensory Receptor Cells / Q000502:physiology*; D015222:Sodium Channels / Q000502:physiology; D013116:Spinal Cord / Q000503:physiopathology; D015854:Up-Regulation
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D015222:Sodium Channels
keywords: Ectopic discharge; Long-term potentiation; Motor fiber; Neuroinflammation; Neuropathic pain