title: Early impact of rotavirus vaccination in a large paediatric hospital in the UK.
abstract: The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.
authors.affiliation: Institute of Infection and Global Health, University of Liverpool, Liverpool, UK; Field Epidemiology Services, Public Health England, Liverpool, UK. Electronic address: d.hungerford@liverpool.ac.uk.
authors.forename: D
authors.initials: D
authors.lastname: Hungerford
authors.affiliation: CHICAS Group, Lancaster Medical School, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Read
authors.affiliation: Department of Microbiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
authors.forename: R P D
authors.initials: RP
authors.lastname: Cooke
authors.affiliation: Field Epidemiology Services, Public Health England, Liverpool, UK.
authors.forename: R
authors.initials: R
authors.lastname: Vivancos
authors.affiliation: Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
authors.forename: M
authors.initials: M
authors.lastname: Iturriza-Gómara
authors.affiliation: Virus Reference Department, Public Health England, Colindale, London, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Allen
authors.affiliation: Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
authors.forename: N
authors.initials: N
authors.lastname: French
authors.affiliation: Institute of Infection and Global Health, University of Liverpool, Liverpool, UK; Department of Microbiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
authors.forename: N
authors.initials: N
authors.lastname: Cunliffe
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000517:prevention & control; D003428:Cross Infection / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000517:prevention & control; D006761:Hospitals; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology; D006113:United Kingdom / Q000453:epidemiology; D014611:Vaccination / Q000706:statistics & numerical data
chemical_list: D022243:Rotavirus Vaccines
keywords: Epidemiology; Healthcare-associated infection; Rotavirus; Vaccination