title: Structure and Noncanonical Activities of Coat Proteins of Helical Plant Viruses.
abstract: The main function of virus coat protein is formation of the capsid that protects the virus genome against degradation. However, besides the structural function, coat proteins have many additional important activities in the infection cycle of the virus and in the defense response of host plants to viral infection. This review focuses on noncanonical functions of coat proteins of helical RNA-containing plant viruses with positive genome polarity. Analysis of data on the structural organization of coat proteins of helical viruses has demonstrated that the presence of intrinsically disordered regions within the protein structure plays an important role in implementation of nonstructural functions and largely determines the multifunctionality of coat proteins.
authors.affiliation: Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Moscow, 119991, Russia. kalinina@genebee.msu.ru.
authors.forename: V V
authors.initials: VV
authors.lastname: Makarov
authors.forename: N O
authors.initials: NO
authors.lastname: Kalinina
mesh_terms: D000595:Amino Acid Sequence; D036022:Capsid Proteins / Q000378:metabolism* / Q000502:physiology; D008969:Molecular Sequence Data; D010942:Plant Viruses / Q000378:metabolism*; D011487:Protein Conformation; D012328:RNA Viruses / Q000378:metabolism*; D016415:Sequence Alignment
chemical_list: D036022:Capsid Proteins