title: Cerebral Microdialysis.
abstract: A variety of neuromonitoring techniques are available to aid in the care of neurocritically ill patients. However, traditional monitors lack the ability to measure brain biochemistry and may provide inadequate warning of potentially reversible deleterious conditions. Cerebral microdialysis (CMD) is a safe, novel method of monitoring regional brain biochemistry. Analysis of CMD analytes as part of a multimodal approach may help inform clinical decision making, guide medical treatments, and aid in prognostication of patient outcome. Its use is most frequently documented in traumatic brain injury and subarachnoid hemorrhage. Incorporating CMD into clinical practice is a multidisciplinary effort.
authors.affiliation: Department of Nursing, Hospital of the University of Pennsylvania, 3400 Spruce Street, 2nd Floor Rhoads Building, Philadelphia, PA 19104, USA. Electronic address: Bethany.young@uphs.upenn.edu.
authors.forename: Bethany
authors.initials: B
authors.lastname: Young
authors.affiliation: Department of Neurology, University of Pennsylvania, 3400 Spruce Street, 3 West Gates Building, Philadelphia, PA 19104, USA.
authors.forename: Atul
authors.initials: A
authors.lastname: Kalanuria
authors.affiliation: Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 3 West Gates Building, Philadelphia, PA 19104, USA.
authors.forename: Monisha
authors.initials: M
authors.lastname: Kumar
authors.affiliation: Penn Presbyterian Medical Center, Philadelphia, PA 19104, USA.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Burke
authors.affiliation: Department of Neurology, University of Pennsylvania, 3400 Spruce Street, 3 West Gates Building, Philadelphia, PA 19104, USA.
authors.forename: Ramani
authors.initials: R
authors.lastname: Balu
authors.affiliation: Department of Nursing, Hospital of the University of Pennsylvania, 3400 Spruce Street, 2nd Floor Rhoads Building, Philadelphia, PA 19104, USA.
authors.forename: Olivia
authors.initials: O
authors.lastname: Amendolia
authors.affiliation: Department of Nursing, Hospital of the University of Pennsylvania, 3400 Spruce Street, 2nd Floor Rhoads Building, Philadelphia, PA 19104, USA.
authors.forename: Kyle
authors.initials: K
authors.lastname: McNulty
authors.affiliation: Department of Nursing, Hospital of the University of Pennsylvania, 3400 Spruce Street, 2nd Floor Rhoads Building, Philadelphia, PA 19104, USA.
authors.forename: BethAnn
authors.initials: B
authors.lastname: Marion
authors.affiliation: Department of Nursing, Hospital of the University of Pennsylvania, 3400 Spruce Street, 2nd Floor Rhoads Building, Philadelphia, PA 19104, USA.
authors.forename: Brittany
authors.initials: B
authors.lastname: Beckmann
authors.affiliation: Department of Nursing, Hospital of the University of Pennsylvania, 3400 Spruce Street, 2nd Floor Rhoads Building, Philadelphia, PA 19104, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Ciocco
authors.affiliation: Department of Nursing, Hospital of the University of Pennsylvania, 3400 Spruce Street, 2nd Floor Rhoads Building, Philadelphia, PA 19104, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Miller
authors.affiliation: Department of Nursing, Hospital of the University of Pennsylvania, 3400 Spruce Street, 2nd Floor Rhoads Building, Philadelphia, PA 19104, USA.
authors.forename: Donnamarie
authors.initials: D
authors.lastname: Schuele
authors.affiliation: Department of Neurosurgery, University of Pennsylvania, 3400 Spruce Street, 3 West Gates Building, Philadelphia, PA 19104, USA.
authors.forename: Eileen
authors.initials: E
authors.lastname: Maloney-Wilensky
authors.affiliation: Department of Neurosurgery, University of Pennsylvania, 3400 Spruce Street, 3 West Gates Building, Philadelphia, PA 19104, USA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Frangos
authors.affiliation: Department of Nursing, Hospital of the University of Pennsylvania, 3400 Spruce Street, 2nd Floor Rhoads Building, Philadelphia, PA 19104, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Wright
mesh_terms: D001921:Brain / Q000378:metabolism; D001930:Brain Injuries / Q000378:metabolism* / Q000451:nursing; D006801:Humans; D017551:Microdialysis / Q000295:instrumentation* / Q000379:methods*; D013345:Subarachnoid Hemorrhage / Q000378:metabolism / Q000451:nursing
keywords: Brain energy crisis; Brain metabolism; Cerebral microdialysis; Lactate/pyruvate ratio; Multimodality monitoring