title: Time-dependent and independent neurophysiological indicators of prognosis in post-anoxic coma subjects treated by therapeutic hypothermia.
abstract: Evaluation of prognostic value of electroencephalography (EEG) and somatosensory evoked potentials (SEP) according to different recording times.
  
  
  
  A retrospective cohort study performed at the medical ICU of the AOU Careggi Teaching Hospital (Florence, Italy) of comatose adults (>18 years) after cardiac arrest (CA) and treated with therapeutic hypothermia (TH). We evaluated the Glasgow Coma Scale, EEG, and SEP performed at 12, 24, and 72 hrs after CA. Outcome was determined by the Glasgow Outcome Scale at 6 months after CA.
  
  
  
  We analyzed 167 patients. All patients with grade 1 EEG ("continuous") within 12 hours of CA recovered consciousness (false positive rate: 0.0%). Grade 2 EEG ("non-continuous") at 72 hours predicted a poor outcome with FPR=0.0%. Bilateral absent SEP at any time after CA predicted a poor outcome.
  
  
  
  EEG is a reliable time-dependent predictor of a good outcome (within 12 hours) and a poor outcome (after 72 hours). SEP is a time-independent predictor of a poor outcome.
authors.affiliation: SODc Neurofisiopatologia, Dipartimento Neuromuscolo-Scheletrico e degli Organi di Senso, AOU Careggi, Florence, Italy - riccardo.carrai@unifi.it.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Carrai
authors.forename: Antonello
authors.initials: A
authors.lastname: Grippo
authors.forename: Maenia
authors.initials: M
authors.lastname: Scarpino
authors.forename: Maddalena
authors.initials: M
authors.lastname: Spalletti
authors.forename: Cesarina
authors.initials: C
authors.lastname: Cossu
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lanzo
authors.forename: Adriano
authors.initials: A
authors.lastname: Peris
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cianchi
authors.forename: Stefano
authors.initials: S
authors.lastname: Batacchi
authors.forename: Serafina
authors.initials: S
authors.lastname: Valente
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Gensini
authors.forename: Aldo
authors.initials: A
authors.lastname: Amantini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003128:Coma / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory; D005260:Female; D015600:Glasgow Coma Scale; D006323:Heart Arrest / Q000150:complications*; D006801:Humans; D007036:Hypothermia, Induced; D007558:Italy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult