title: [A case of myasthenia gravis with transient taste disorders followed by aplastic anemia after thymectomy].
abstract: A 45-year-old man was admitted to our hospital because of taste disorders in March 2014. He exhibited cervical muscle weakness and left eye ptosis, which responded to Tensilon test, and was diagnosed with myasthenia gravis (MG). He developed aspiration pneumonia and myasthenic crisis, which was treated with intravenous immunoglobulin and steroid pulse therapy. All symptoms disappeared. Oral administration of prednisolone and tacrolimus was started. Chest CT revealed thymoma and extended thymectomy was performed in May 2014. In December 2014, seven months after the thymectomy, hematological examination showed pancytopenia including severe neutropenia. We diagnosed his illness as aplastic anemia (AA). Cyclosporine therapy with transfusion was administerd and led to reticulocyte count recovery. Since May 2015, hemoglobin recovery reached a blood transfusion free period. To our knowledge, this is the first case report with the patient supposed of relationship among taste disorders, AA and thymoma-associated MG.
authors.affiliation: Department of Neurology, Fukaya Red Cross Hospital.
authors.forename: Osamu
authors.initials: O
authors.lastname: Osada
authors.forename: Akira
authors.initials: A
authors.lastname: Iwasaki
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Nakahashi
authors.forename: Yoshitora
authors.initials: Y
authors.lastname: Kim
authors.forename: Kou
authors.initials: K
authors.lastname: Kaneko
mesh_terms: D000741:Anemia, Aplastic / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications* / Q000628:therapy; D013651:Taste Disorders / Q000209:etiology*; D013934:Thymectomy