title: Relationship of coronary collateral circulation with eosinophils in patients with unstable angina pectoris.
abstract: BACKGROUND
  Eosinophils (EOS) have been associated with prognosis of patients with coronary artery disease, and those who showed plenitudinous coronary collateral circulation (CCC) often have good clinical consequences. However, the relationship between EOS and CCC was seldom reported.
  
  
  OBJECTIVE
  To investigate the relationship between EOS and CCC development in patients with unstable angina pectoris (UAP).
  
  
  METHODS
  The study population consisted of 502 consecutive patients with UAP who underwent coronary angiography and coronary stenosis ≥80%. CCC was graded according to the Rentrop grading system of 0-3. Rentrop grades of 0 and 1 indicated low-grade CCC group, whereas grades 2 and 3 indicated high-grade CCC group.
  
  
  RESULTS
  The EOS was significantly higher in the high-grade CCC group compared with the low-grade CCC group. In multiple logistic regression analysis, EOS (odds ratio: 1.969; 95% confidence interval [CI]: 1.210-3.3205; P=0.006) and neutrophil count (odds ratio: 0.757; 95% CI: 0.584-0.981; P=0.035) were predictors of high-grade CCC development. EOS of >0.12×10(9)/L could independently predict high-grade CCC with 72.5% sensitivity and 58.4% specificity (area under the curve: 0.681; 95% CI: 0.632-0.729).
  
  
  CONCLUSIONS
  EOS were associated with high-grade CCC in patients with UAP with coronary stenosis ≥80%. Increased EOS count may play an important role in the development of CCC in patients with UAP.
authors.affiliation: Department of Cardiology, Beijing Mentougou District Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Cardiology, Beijing Mentougou District Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Shi-jing
authors.initials: SJ
authors.lastname: Li
authors.affiliation: Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: De-zhao
authors.initials: DZ
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Bu-xing
authors.initials: BX
authors.lastname: Chen
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000097:blood*; D002681:China; D003097:Collateral Circulation; D017023:Coronary Angiography; D003326:Coronary Circulation; D003430:Cross-Sectional Studies; D004804:Eosinophils / Q000166:cytology*; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012372:ROC Curve; D012189:Retrospective Studies
keywords: coronary artery disease; coronary collateral circulation; eosinophils; unstable angina pectoris