title: Normal values and standardization of parameters in nuclear cardiology: Japanese Society of Nuclear Medicine working group database.
abstract: As a 2-year project of the Japanese Society of Nuclear Medicine working group activity, normal myocardial imaging databases were accumulated and summarized. Stress-rest with gated and non-gated image sets were accumulated for myocardial perfusion imaging and could be used for perfusion defect scoring and normal left ventricular (LV) function analysis. For single-photon emission computed tomography (SPECT) with multi-focal collimator design, databases of supine and prone positions and computed tomography (CT)-based attenuation correction were created. The CT-based correction provided similar perfusion patterns between genders. In phase analysis of gated myocardial perfusion SPECT, a new approach for analyzing dyssynchrony, normal ranges of parameters for phase bandwidth, standard deviation and entropy were determined in four software programs. Although the results were not interchangeable, dependency on gender, ejection fraction and volumes were common characteristics of these parameters. Standardization of (123)I-MIBG sympathetic imaging was performed regarding heart-to-mediastinum ratio (HMR) using a calibration phantom method. The HMRs from any collimator types could be converted to the value with medium-energy comparable collimators. Appropriate quantification based on common normal databases and standard technology could play a pivotal role for clinical practice and researches.
authors.affiliation: Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641, Japan. nakajima@med.kanazawa-u.ac.jp.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nakajima
authors.affiliation: Department of Cardiology, Nihon University Hospital, Tokyo, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Matsumoto
authors.affiliation: Department of Cardiology, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.
authors.forename: Tokuo
authors.initials: T
authors.lastname: Kasai
authors.affiliation: Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
authors.forename: Shinro
authors.initials: S
authors.lastname: Matsuo
authors.affiliation: Department of Radiology, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kiso
authors.affiliation: Department of Physics, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Okuda
mesh_terms: D002309:Cardiology / Q000592:standards*; D016208:Databases, Factual; D006801:Humans; D007564:Japan; D009683:Nuclear Medicine / Q000592:standards*; D012015:Reference Standards; D012016:Reference Values; D012955:Societies, Medical
keywords: 123I-Metaiodobenzylguanidine (MIBG) quantification; Japanese Society of Nuclear Medicine (JSNM) working group; Myocardial perfusion imaging; Normal database