title: Angiosarcoma of the thoracic wall responded well to nanoparticle albumin-bound paclitaxel: A case report.
abstract: An 81-year-old woman visited a local clinic due to chest pain and a skin induration on the right precordia. She had a history of right breast cancer, and she had undergone a mastectomy and radiation therapy 10 years prior. Computed tomography (CT) imaging of the chest demonstrated a lobular mass that involved the right anterior thoracic wall and partially extruded from the thoracic cavity into the subcutaneous tissue. The tumor was surgically excised, and pathological analyses yielded a diagnosis of angiosarcoma. Five months after the operation, CT imaging showed multiple masses on the right pleura, indicating a local relapse and pleural dissemination of the angiosarcoma. Systemic chemotherapy composed of nanoparticle albumin-bound paclitaxel (nab-PTX) (80 mg/m(2)) was delivered weekly. After 4 courses of chemotherapy, the tumors regressed remarkably. Nab-PTX may be an effective treatment option for recurrent or metastatic angiosarcoma.
authors.affiliation: Department of Respiratory Medicine, Okayama Rosai Hospital.
authors.forename: Naofumi
authors.initials: N
authors.lastname: Hara
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Fujimoto
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yamagishi
authors.forename: Michiko
authors.initials: M
authors.lastname: Asano
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Fuchimoto
authors.forename: Sae
authors.initials: S
authors.lastname: Wada
authors.forename: Shinji
authors.initials: S
authors.lastname: Ozaki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Nishi
authors.forename: Takumi
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D000369:Aged, 80 and over; D000068196:Albumin-Bound Paclitaxel / Q000008:administration & dosage / Q000627:therapeutic use*; D000418:Albumins / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006394:Hemangiosarcoma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D010994:Pleura / Q000473:pathology; D013899:Thoracic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D035441:Thoracic Wall; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000068196:Albumin-Bound Paclitaxel; D000418:Albumins; D000972:Antineoplastic Agents, Phytogenic