title: The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems.
abstract: Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor's role in the adapted immunity and inflammation as well as the receptor's expression and function in the CNS with the focus on astrocytes. We also discuss expression and signalling of oxysterol-producing enzymes such as CH25H and CYP7B1 in the CNS and the immune system. These steps will help to elucidate a possible role for this pathway in the physiology of the central and peripheral nervous system and its possible link to human disease.
authors.affiliation: School of Medicine, Department of Physiology, Trinity College Dublin, Dublin 152 - 160 Pearse Street, Ireland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Rutkowska
authors.forename: Kumlesh K
authors.initials: KK
authors.lastname: Dev
authors.affiliation: Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Forum 1, CH-4002, Switzerland.
authors.forename: Andreas W
authors.initials: AW
authors.lastname: Sailer
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism*; D000072474:Cytochrome P450 Family 7 / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism; D000072376:Oxysterols / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D013250:Steroid Hydroxylases / Q000378:metabolism
chemical_list: C080105:GPR183 protein, human; D000072376:Oxysterols; D043562:Receptors, G-Protein-Coupled; D013250:Steroid Hydroxylases; D000072474:Cytochrome P450 Family 7; C499571:CYP7B1 protein, human