title: [HLA- haploidentical donor hematopoietic transplantation for severe aplastic anemia achieved comparable outcomes with HLA- unrelated donor transplantation].
abstract: OBJECTIVE
  To evaluate the efficacy of HLA- haploidentical donor hematopoietic transplantation (Haplo- HSCT)for severe aplastic anemia (SAA)by compared with the same period of unrelated donor transplantation (UD- HSCT).
  
  
  METHODS
  Of a cohort of 50 SAA patients between September 2012 and July 2014, 26 patients underwent UD- HSCT and 24 patients Haplo- HSCT.
  
  
  RESULTS
  OS rate was 91.3% with a median follow-up of 9 (2-26)months. According to transplant type, there was no significant difference between UD- and Haplo-HSCT (96.1%vs 86.0%,P=0.30). 3 of 50 (6%)patients had primary engraft failure. Haplo- HSCT developed higher significantly incidence of Ⅱ- Ⅳ aGVHD (37.5%vs 3.83%,P=0.003)and cGVHD (37.5%vs 15.3%,P=0.030)than UD-HSCT. Haplo-HSCT also had significantly higher incidences of CMV viremia (78.2%vs 46.1%,P=0.005)and EBV viremia (43.1%vs 16.0%,P=0.040), respectively than UD-HSCT. But the incidences of hemorrhagic cystitis were similar between two transplant types (39.1%vs 23.0%,P=0.120).
  
  
  CONCLUSIONS
  This study showed favorable outcome of Haplo-HSCT for SAA, which was comparable with UD-HSCT.
authors.affiliation: Ludaopei Hematology & Oncology Center, Yanda International Hospital, Hebei Langfang 065200, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Lu
authors.forename: Tong
authors.initials: T
authors.lastname: Wu
authors.forename: Xingyu
authors.initials: X
authors.lastname: Cao
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhao
authors.forename: Deyan
authors.initials: D
authors.lastname: Liu
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Sun
authors.forename: Min
authors.initials: M
authors.lastname: Xiong
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Wei
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhang
authors.forename: Jiarui
authors.initials: J
authors.lastname: Zhou
authors.forename: Daopei
authors.initials: D
authors.lastname: Lu
mesh_terms: D000741:Anemia, Aplastic / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015994:Incidence; D016896:Treatment Outcome; D061349:Unrelated Donors