title: [The clinical analysis of orthotopic liver transplantation for primary biliary cirrhosis].
abstract: OBJECTIVE
  To analyze the clinical outcome and complications of orthotopic liver transplantation (OLT) for patients with primary biliary cirrhosis(PBC).
  
  
  METHODS
  Clinical data of 25 patients with PBC who underwent OLT were analyzed retrospectively. The postoperative cumulative survival rate of the patients was calculated. The postoperative recurrence of PBC, de novo diseases and other complications were analyzed.
  
  
  RESULTS
  A total of 25 patients were recruited including 22 females and 3 males. The average age was 49.1 years (range from 40 to 64 years). The score of model for end-stage liver disease (MELD) was 21.80±5.49, and the Mayo score 8.01±1.38. Four patients died after liver transplantation. The 1-year, 2-year and 7-year patient cumulative survival rates were 92.0%, 87.8% and 75.3%, respectively. Eight cases (32.0%) developed recurrent PBC based on histological evidence. The median time to recurrence was 17.5 months. One of the eight patients with recurrent PBC was diagnosed with de novo auto-immune hepatitis (AIH) simultaneously, who eventually died. Acute rejection and de novo hepatitis B virus (HBV) infection developed in thirteen (52.0%) patients and five (20.0%) patients, respectively. Two cases (8.0%) of de novo AIH were diagnosed, one of which was fatal.
  
  
  CONCLUSIONS
  OLT is an effective procedure for end-stage PBC. Much attention needs to be paid to the post-transplantation complications, including recurrence of primary disease, combined de novo HBV infection, de novo AIH, etc.
authors.forename: Shuangnan
authors.initials: S
authors.lastname: Zhou
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Zhenwen
authors.initials: Z
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Yao
authors.forename: Yinjie
authors.initials: Y
authors.lastname: Gao
authors.forename: Xia
authors.initials: X
authors.lastname: Zhou
authors.forename: Dali
authors.initials: D
authors.lastname: Zhang
authors.forename: Rujia
authors.initials: R
authors.lastname: Tang
authors.forename: Hongling
authors.initials: H
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Liver Transplantation Center, 302 Hospital of PLA, Beijing 100039, China; Email: suhaibin@medmail.com.cn.
authors.forename: Haibin
authors.initials: H
authors.lastname: Su
mesh_terms: D000328:Adult; D005260:Female; D006515:Hepatitis B virus; D019693:Hepatitis, Autoimmune / Q000209:etiology*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D011184:Postoperative Period; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate