title: Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism.
abstract: In this overview, we provide an update on recent progress made in understanding the mechanisms of action, physiological functions, and roles in disease of retinoic acid related orphan receptors (RORs). We are particularly focusing on their roles in the regulation of adaptive and innate immunity, brain function, retinal development, cancer, glucose and lipid metabolism, circadian rhythm, metabolic and inflammatory diseases and neuropsychiatric disorders. We also summarize the current status of ROR agonists and inverse agonists, including their regulation of ROR activity and their therapeutic potential for management of various diseases in which RORs have been implicated.
authors.affiliation: Immunogenetics Section, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
authors.forename: Donald N
authors.initials: DN
authors.lastname: Cook
authors.affiliation: Cell Biology Section, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
authors.forename: Hong Soon
authors.initials: HS
authors.lastname: Kang
authors.affiliation: Cell Biology Section, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
authors.forename: Anton M
authors.initials: AM
authors.lastname: Jetten
keywords: RORα; RORβ; RORγ; Th17 cells; agonists; antagonist; autism; autoimmune disease; brain; cancer; cholesterol biosynthesis; circadian clock; diabetes; glucose homeostasis; immunity; innate lymphoid cells; insulin sensitivity; lipid metabolism; metabolism; retina; retinoic acid-related orphan receptor; transcription