title: [Correlation between VE/VCO2slope and echocardiographic derived systolic pulmonary artery pressure in patients with chronic heart failure].
abstract: OBJECTIVE
  To explore the relationship between ventilator efficiency of cardiopulmonary exercising test (the slope of the relation between ventilation and carbon dioxide production, VE/VCO(2)slope) and systolic pulmonary artery pressure (sPAP) measured by echocardiography in patients with chronic heart failure (HF).
  
  
  METHODS
  Data from 86 HF patients who were treated in Fuwai Hospital between December 2012 and July 2014 and performed the symptom limited maximal cardiopulmonary exercise test (CPET) and echocardiography were retrospectively analyzed.H F patients were divided into 3 groups (mild, moderate and severe) according to the maximum oxygenconsumption (peakVO(2)).
  
  
  RESULTS
  There is a significant linear correlation between VE/VCO(2)slope and sPAP (r=0.260, P=0.016). Using VE/VCO(2)slope>34.2 as a cutoff value to predict patients with sPAP>50 mmHg (1 mmHg=0.133 kPa) yielded a sensitivity of 70.0% and a specificity of 64.3%. The degree of the linear correlation between VE/VCO(2)slope and sPAP is stronger in mild HF patients (peakVO(2)>14 ml·kg(-1)·min(-1), r=0.686, P<0.001). Using VE/VCO(2) slope>34.2 as a cutoff value to predict sPAP>50 mmHg in mild HF patients, the sensitivity is 71.4% and the specificity is 93.8%.
  
  
  CONCLUSIONS
  There is a significant linear correlation between VE/VCO(2)slope and sPAP in HF patients. VE/VCO(2)slope>34.2 is linked with a high possibility of sPAP>50 mmHg in HF patients, especially for patients with mild HF. Invasive hemodynamic examination and impact of special therapy are warranted in future studies to veryfy present results.
authors.affiliation: Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Zhigao
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Email: huangjie@medmail.com.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.forename: Xingguo
authors.initials: X
authors.lastname: Sun
authors.forename: Shengshou
authors.initials: S
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zheng
authors.forename: Yunhu
authors.initials: Y
authors.lastname: Song
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
mesh_terms: D002245:Carbon Dioxide; D002908:Chronic Disease; D004452:Echocardiography; D005080:Exercise Test; D006333:Heart Failure; D006439:Hemodynamics; D006801:Humans; D011651:Pulmonary Artery; D012189:Retrospective Studies
chemical_list: D002245:Carbon Dioxide