title: Susceptibility of Multidrug-Resistant Gram-Negative Urine Isolates to Oral Antibiotics.
abstract: Increasing resistance among Gram-negative uropathogens limits treatment options, and susceptibility data for multidrug-resistant isolates are limited. We assessed the activity of five oral agents against 91 multidrug-resistant Gram-negative urine isolates that were collected from emergency department/hospitalized patients. Fosfomycin and nitrofurantoin were most active (>75% susceptibility). Susceptibilities to sulfamethoxazole-trimethoprim, ciprofloxacin, and ampicillin were ≤40%; empirical use of these agents likely provides inadequate coverage in areas with a high prevalence of multidrug-resistant uropathogens.
authors.affiliation: Northeastern University, Boston, Massachusetts, USA Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA e.hirsch@neu.edu.
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Hirsch
authors.affiliation: Northeastern University, Boston, Massachusetts, USA.
authors.forename: Paola C
authors.initials: PC
authors.lastname: Zucchi
authors.affiliation: Northeastern University, Boston, Massachusetts, USA.
authors.forename: Alice
authors.initials: A
authors.lastname: Chen
authors.affiliation: Northeastern University, Boston, Massachusetts, USA.
authors.forename: Brian R
authors.initials: BR
authors.lastname: Raux
authors.affiliation: Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Kirby
authors.affiliation: Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: McCoy
authors.affiliation: Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: George M
authors.initials: GM
authors.lastname: Eliopoulos
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005578:Fosfomycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009582:Nitrofurantoin / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology; D014552:Urinary Tract Infections / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D002939:Ciprofloxacin; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D009582:Nitrofurantoin