title: Emergence of influenza A (H1N1)pdm09 genogroup 6B and drug resistant virus, India, January to May 2015.
abstract: To investigate the aetiology of the 2015 A(H1N1)pdm09 influenza outbreak in India, 1,083 nasopharyngeal swabs from suspect patients were screened for influenza A(H1N1)pdm09 in the state of Madhya Pradesh. Of 412 positive specimens, six were further characterised by phylogenetic analysis of haemagglutinin (HA) sequences revealing that they belonged to genogroup 6B. A new mutation (E164G) was observed in HA2 of two sequences. Neuraminidase genes in two of 12 isolates from fatal cases on prior oseltamivir treatment harboured the H275Y mutation.
authors.affiliation: Division of Virology, Defence Research & Development Establishment (DRDE), Gwalior, India.
authors.forename: Manmohan
authors.initials: M
authors.lastname: Parida
authors.forename: Paban Kumar
authors.initials: PK
authors.lastname: Dash
authors.forename: Jyoti S
authors.initials: JS
authors.lastname: Kumar
authors.forename: Gaurav
authors.initials: G
authors.lastname: Joshi
authors.forename: Kundan
authors.initials: K
authors.lastname: Tandel
authors.forename: Shashi
authors.initials: S
authors.lastname: Sharma
authors.forename: Ambuj
authors.initials: A
authors.lastname: Srivastava
authors.forename: Ankita
authors.initials: A
authors.lastname: Agarwal
authors.forename: Amrita
authors.initials: A
authors.lastname: Saha
authors.forename: Shweta
authors.initials: S
authors.lastname: Saraswat
authors.forename: Divyanshi
authors.initials: D
authors.lastname: Karothia
authors.forename: Vatsala
authors.initials: V
authors.lastname: Malviya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005838:Genotype; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics*; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics* / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology*; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D009305:Nasopharynx / Q000821:virology; D009439:Neuraminidase / Q000235:genetics; D053139:Oseltamivir / Q000627:therapeutic use; D010802:Phylogeny; D011159:Population Surveillance; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D053139:Oseltamivir; D009439:Neuraminidase
keywords: H1N1; Swine Flu; drug resistance; genogroup; pandemic; phylogeny