title: Association between HTR2A T102C polymorphism and major depressive disorder: a meta-analysis in the Chinese population.
abstract: Although a number of studies have been conducted on the association between HTR2A T102C polymorphism and major depressive disorder (MDD) in Chinese, this association remains elusive and controversial. To clarify the effects of HTR2A T102C polymorphism on the risk of MDD, a meta-analysis was performed in the Chinese population. Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) till 5 May 2015. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations. Statistical analyses were conducted with Version 10.0 STATA statistical software. A total of 12 case-control studies including 1444 MDD cases and 1445 controls were involved in this meta-analysis. Overall, no significant association with MDD risk was provided in the Chinese population (C vs. T: OR=0.97, 95% CI: 0.81-1.17, 95%; CC vs. TT: OR=0.95, 95% CI: 0.65-1.37; CC+TC vs. TT: OR=0.96, 95% CI: 0.75-1.12; CC vs. TT+TC: OR=0.94, 95% CI: 0.78-1.12). In subgroup analyses stratified by geographic area and source of controls, no significant association was found in any of the subgroups. In conclusion, this meta-analysis indicate that the HTR2A T102C polymorphism is not associated with susceptibility to MDD in Chinese population.
authors.affiliation: Institute of Neurology, Guangdong Key Laboratory of Age-Related Cardiac-Cerebral Vascular Disease, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Lin
authors.affiliation: Department of Anesthesiology, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Vascular Surgery, Thyroid and Mammary Gland Surgery, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Ze-Ming
authors.initials: ZM
authors.lastname: Yan
authors.affiliation: Institute of Neurology, Guangdong Key Laboratory of Age-Related Cardiac-Cerebral Vascular Disease, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: Institute of Neurology, Guangdong Key Laboratory of Age-Related Cardiac-Cerebral Vascular Disease, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Yu-Sen
authors.initials: YS
authors.lastname: Chen
authors.affiliation: Institute of Neurology, Guangdong Key Laboratory of Age-Related Cardiac-Cerebral Vascular Disease, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Jiang-Hao
authors.initials: JH
authors.lastname: Zhao
authors.affiliation: Department of Anesthesiology, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Liang-Qing
authors.initials: LQ
authors.lastname: Zhang
authors.affiliation: Institute of Neurology, Guangdong Key Laboratory of Age-Related Cardiac-Cerebral Vascular Disease, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Institute of Neurology, Guangdong Key Laboratory of Age-Related Cardiac-Cerebral Vascular Disease, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Wang-Tao
authors.initials: WT
authors.lastname: Zhong
authors.affiliation: Institute of Neurology, Guangdong Key Laboratory of Age-Related Cardiac-Cerebral Vascular Disease, Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Du
authors.initials: D
authors.lastname: Feng
keywords: HTR2A-T102C; Meta-analysis; major depressive disorder; polymorphism