title: Oxidation of cefazolin by potassium permanganate: Transformation products and plausible pathways.
abstract: Cefazolin was demonstrated to exert high reactivity toward permanganate (Mn(VII)), a common oxidant in water pre-oxidation treatment. In this study, five transformation products were found to be classified into three categories according to the contained characteristic functional groups: three (di-)sulfoxide products, one sulfone product and one di-ketone product. Products analyses showed that two kinds of reactions including oxidation of thioether and the cleavage of unsaturated CC double bond occurred during transformation of cefazolin by Mn(VII). Subsequently, the plausible transformation pathways under different pH conditions were proposed based on the identified products and chemical reaction principles. More importantly, the simulation with real surface water matrix indicated that the proposed transformation pathways of cefazolin could be replayed in real water treatment practices.
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Liping
authors.initials: L
authors.lastname: Li
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address: weidb@rcees.ac.cn.
authors.forename: Dongbin
authors.initials: D
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Du
mesh_terms: D002437:Cefazolin / Q000032:analysis / Q000737:chemistry*; D017895:Manganese Compounds; D008956:Models, Chemical; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D010087:Oxides; D011196:Potassium Permanganate / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000737:chemistry*; D018508:Water Purification / Q000379:methods
chemical_list: D017895:Manganese Compounds; D016877:Oxidants; D010087:Oxides; D014874:Water Pollutants, Chemical; D011196:Potassium Permanganate; D014867:Water; C048856:permanganic acid; D002437:Cefazolin
keywords: Cefazolin; Formation mechanisms; Oxidative degradation; Pathway; Permanganate; Transformation products