title: RNA Processing and Genome Stability: Cause and Consequence.
abstract: It is emerging that the pathways that process newly transcribed RNA molecules also regulate the response to DNA damage at multiple levels. Here, we discuss recent insights into how RNA processing pathways participate in DNA damage recognition, signaling, and repair, selectively influence the expression of genome-stabilizing proteins, and resolve deleterious DNA/RNA hybrids (R-loops) formed during transcription and RNA processing. The importance of these pathways for the DNA damage response (DDR) is underscored by the growing appreciation that defects in these regulatory connections may be connected to the genome instability involved in several human diseases, including cancer.
authors.affiliation: Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK. Electronic address: vw222@mrc-cu.cam.ac.uk.
authors.forename: Vihandha O
authors.initials: VO
authors.lastname: Wickramasinghe
authors.affiliation: Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK. Electronic address: arv22@mrc-cu.cam.ac.uk.
authors.forename: Ashok R
authors.initials: AR
authors.lastname: Venkitaraman
mesh_terms: D004249:DNA Damage; D004260:DNA Repair; D015894:Genome, Human; D042822:Genomic Instability; D006801:Humans; D012313:RNA / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D015398:Signal Transduction
chemical_list: D012313:RNA