title: Correlation between Molecular Mobility and Physical Stability in Pharmaceutical Glasses.
abstract: We investigated a possible correlation between molecular mobility and physical stability in glassy celecoxib and indomethacin and identified the specific mobility mode responsible for physical instability (crystallization). In the glassy state, because the structural relaxation times are very long, the measurement was enabled by time domain dielectric spectroscopy. However, the local motions in the glassy state were characterized by frequency domain dielectric spectroscopy. Isothermal crystallization was monitored by powder X-ray diffractometry using either a laboratory source (supercooled state) or synchrotron source (glassy state). Structural (α) relaxation time correlated well with characteristic crystallization time in the supercooled state. On the other hand, a stronger correlation was observed between the Johari-Goldstein (β) relaxation time and physical instability in the glassy state but not with structural relaxation time. These results suggest that Johari-Goldstein relaxation is a potential predictor of physical instability in the glassy state of these model systems.
authors.affiliation: Department of Pharmaceutics, University of Minnesota , Minneapolis, Minnesota 55455, United States.
authors.forename: Mehak
authors.initials: M
authors.lastname: Mehta
authors.affiliation: Department of Pharmaceutics, University of Minnesota , Minneapolis, Minnesota 55455, United States.
authors.forename: Vishard
authors.initials: V
authors.lastname: Ragoonanan
authors.affiliation: Department of Chemical Engineering, Texas Tech University , Lubbock, Texas 79409, United States.
authors.forename: Gregory B
authors.initials: GB
authors.lastname: McKenna
authors.affiliation: Department of Pharmaceutics, University of Minnesota , Minneapolis, Minnesota 55455, United States.
authors.forename: Raj
authors.initials: R
authors.lastname: Suryanarayanan
mesh_terms: D002152:Calorimetry, Differential Scanning; D000068579:Celecoxib / Q000737:chemistry*; D003460:Crystallization; D058266:Dielectric Spectroscopy; D005898:Glass / Q000737:chemistry*; D007213:Indomethacin / Q000737:chemistry*
chemical_list: D000068579:Celecoxib; D007213:Indomethacin
keywords: Johari−Goldstein; amorphous; celecoxib; crystallization; dielectric spectroscopy; glassy; indomethacin; structural relaxation