title: Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC.
abstract: We report on a case of intoxication with a mix of new psychoactive substances. A 38-year-old male was brought to the emergency department (ED) following the ingestion of an unknown drug in a suicide attempt. During the transport, he became progressively more somnolent and unresponsive to painful stimuli. Urine and stomach content were collected on admission to be screened for drugs of abuse and medicinal drugs. After admission, the patient's next of kin presented five small grip seal plastic bags containing different powders/crystals, and they were sent for analysis along with urine and stomach content to the toxicology laboratory. An easy and rapid sample preparation technique was applied for the extraction of urine and stomach content. Samples were extracted with liquid-liquid extraction (LLE) technique and analysed using gas chromatography-mass spectrometry (GC-MS). A small amount of powder material from the bags was diluted in methanol and injected directly into the GC-MS instrument. Obtained spectra (EI) were evaluated against SWGDRUG library. Five different designer drugs were identified in the powder material, including synthetic cannabinoids (AB-CHMINACA, AB-FUBINACA) and synthetic cathinones (alpha-PHP, alpha-PVP and 4-CMC). With the exception of 4-CMC, all of these substances were also detected in the stomach content along with the prescription drugs. This is the first time that a positive identification of these five drugs has been made by a clinical laboratory in Slovenia.
authors.affiliation: Department of Laboratory Diagnostics, University Medical Centre Maribor, Slovenia. Electronic address: jani.klavz@t-2.net.
authors.forename: Janez
authors.initials: J
authors.lastname: Klavž
authors.affiliation: Department of Laboratory Diagnostics, University Medical Centre Maribor, Slovenia.
authors.forename: Maksimiljan
authors.initials: M
authors.lastname: Gorenjak
authors.affiliation: Department of Internal Intensive Medicine, University Medical Centre Maribor, Slovenia.
authors.forename: Martin
authors.initials: M
authors.lastname: Marinšek
mesh_terms: D000328:Adult; D000470:Alkaloids / Q000032:analysis / Q000506:poisoning*; D002186:Cannabinoids / Q000032:analysis / Q000506:poisoning*; D003937:Diagnosis, Differential; D053593:Forensic Toxicology; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D011041:Poisoning / Q000175:diagnosis; D011619:Psychotropic Drugs / Q000506:poisoning*; D013406:Suicide, Attempted
chemical_list: D000470:Alkaloids; D002186:Cannabinoids; D011619:Psychotropic Drugs; C023665:cathinone
keywords: Cathinone derivative; GC–MS.; Suicide; Synthetic cannabinoids