title: Perceptions of pharmacogenetic research to guide tobacco cessation by patients, providers and leaders in a tribal healthcare setting.
abstract: OBJECTIVE
  Describe patients,' providers' and healthcare system leaders' perceptions of pharmacogenetic research to guide tobacco cessation treatment in an American Indian/Alaska Native primary care setting.
  
  
  METHODS
  This qualitative study used semistructured interviews with 20 American Indian/Alaska Native current or former tobacco users, 12 healthcare providers and nine healthcare system leaders.
  
  
  RESULTS
  Participants supported pharmacogenetic research to guide tobacco cessation treatment provided that a community-based participatory research approach be employed, research closely coordinate with existing tobacco cessation services and access to pharmacogenetic test results be restricted to providers involved in tobacco cessation.
  
  
  CONCLUSIONS
  Despite a history of mistrust toward genetic research in tribal communities, participants expressed willingness to support pharmacogenetic research to guide tobacco cessation treatment.
authors.affiliation: Research Department, Southcentral Foundation, 4105 Tudor Centre Drive, Anchorage, AK 99508, USA.
authors.forename: Jaedon P
authors.initials: JP
authors.lastname: Avey
authors.affiliation: Research Department, Southcentral Foundation, 4105 Tudor Centre Drive, Anchorage, AK 99508, USA.
authors.forename: Vanessa Y
authors.initials: VY
authors.lastname: Hiratsuka
authors.affiliation: Research Department, Southcentral Foundation, 4105 Tudor Centre Drive, Anchorage, AK 99508, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Beans
authors.affiliation: Department of Bioethics & Humanities, University of Washington, Box 357120, Seattle, WA 98195-7120, USA.
authors.forename: Susan Brown
authors.initials: SB
authors.lastname: Trinidad
authors.affiliation: Campbell Family Mental Health Research Institute, Centre for Addiction & Mental Health, Departments of Psychiatry, and Pharmacology & Toxicology, University of Toronto, Medical Science Building Room 4326, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
authors.forename: Rachel F
authors.initials: RF
authors.lastname: Tyndale
authors.affiliation: Research Department, Southcentral Foundation, 4105 Tudor Centre Drive, Anchorage, AK 99508, USA.
authors.forename: Renee F
authors.initials: RF
authors.lastname: Robinson
mesh_terms: D000413:Alaska; D055812:Community-Based Participatory Research; D003159:Community-Institutional Relations; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007198:Indians, North American; D010597:Pharmacogenetics; D011320:Primary Health Care; D036301:Qualitative Research; D020340:Tobacco Use Cessation / Q000523:psychology*
keywords: American Indian/Alaska Native; academic–community partnership; community-based participatory research; genetic research; pharmacogenetics; tobacco cessation