title: The role of Notch signaling in kidney podocytes.
abstract: The Notch signaling pathway is a basic cell-to-cell communication mechanism. This pathway is activated by the interaction between Notch receptors and the ligands of adjacent cells. Once activated, Notch receptors are cleaved and the intracellular domains translocate into the nucleus, where the transcription of target genes starts. In the mammalian kidney, Notch receptors are activated during nephrogenesis. Afterwards, in the mature glomeruli, the Notch pathway becomes silent. However, many researchers have reported the activation of Notch receptors in mature podocytes under pathological conditions. In this review, we discuss the role of Notch signaling in podocytes.
authors.affiliation: Medical Innovation Center, TMK Project, Graduate School of Medicine, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. asanuma@tmk.med.kyoto-u.ac.jp.|Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan. asanuma@tmk.med.kyoto-u.ac.jp.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Asanuma
authors.affiliation: Medical Innovation Center, TMK Project, Graduate School of Medicine, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
authors.forename: Juan Alejandro
authors.initials: JA
authors.lastname: Oliva Trejo
authors.affiliation: Department of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism* / Q000473:pathology; D008024:Ligands; D050199:Podocytes / Q000378:metabolism* / Q000473:pathology; D051883:Receptor, Notch2 / Q000378:metabolism; D000071656:Receptor, Notch3 / Q000378:metabolism; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008024:Ligands; D051883:Receptor, Notch2; D000071656:Receptor, Notch3; D051880:Receptors, Notch
keywords: Apopotosis; Glomerulosclerosis; Notch; Podocyte; Proteinuria