title: Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects.
abstract: Various lines of published evidence have already demonstrated the impact of TRPV1 agonists on energetic metabolism through the stimulation of the sympathetic nervous system (SNS). This study presents a trial investigating if stimulation of the two related sensory receptors TRPA1 and TRPM8 could also stimulate the SNS and impact the energetic metabolism of healthy subjects. The trial was designed to be double-blinded, randomized, cross-over, placebo-controlled with healthy subjects and the impact on the energetic metabolism and the autonomic nervous system (ANS) of cinnamaldehyde, capsaicin and a cooling flavor was measured during the 90 min after ingestion. Energy expenditure and substrate oxidation were measured by indirect calorimetry. An exploratory method to measure ANS activity was by facial thermography and power spectral analysis of heart rate variability using ECG was also used. Following cinnamaldehyde ingestion, energy expenditure was increased as compared to placebo. Furthermore, postprandial fat oxidation was maintained higher compared to placebo after cinnamaldehyde and capsaicin ingestion. Similar peripheral thermoregulation was observed after capsaicin and cinnamaldehyde ingestion. Unlike capsaicin, the dose of cinnamaldehyde was not judged to be sensorially 'too intense' by participants suggesting that Cinnamaldehyde would be a more tolerable solution to improve thermogenesis via spicy ingredients as compared to capsaicin.
authors.affiliation: Nestlé Research Center, Vers-chez-les-Blanc, Lausanne, Switzerland.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Michlig
authors.affiliation: Nestlé Research Center, Vers-chez-les-Blanc, Lausanne, Switzerland.
authors.forename: Jenny Meylan
authors.initials: JM
authors.lastname: Merlini
authors.affiliation: Nestlé Research Center, Vers-chez-les-Blanc, Lausanne, Switzerland.
authors.forename: Maurice
authors.initials: M
authors.lastname: Beaumont
authors.affiliation: Nestlé Research Center, Vers-chez-les-Blanc, Lausanne, Switzerland.
authors.forename: Mirko
authors.initials: M
authors.lastname: Ledda
authors.affiliation: Nestlé Research Center, Vers-chez-les-Blanc, Lausanne, Switzerland.
authors.forename: Aude
authors.initials: A
authors.lastname: Tavenard
authors.affiliation: Nestlé Research Center, Vers-chez-les-Blanc, Lausanne, Switzerland.
authors.forename: Rajat
authors.initials: R
authors.lastname: Mukherjee
authors.affiliation: Nestlé Research Center, Vers-chez-les-Blanc, Lausanne, Switzerland.
authors.forename: Susana
authors.initials: S
authors.lastname: Camacho
authors.affiliation: Nestlé Research Center, Vers-chez-les-Blanc, Lausanne, Switzerland.|The University of Tokyo, Organization for Interdisciplinary Research Projects, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Johannes
authors.initials: J
authors.lastname: le Coutre
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives / Q000494:pharmacology; D000328:Adult; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D015220:Calcium Channels; D002211:Capsaicin / Q000494:pharmacology; D018592:Cross-Over Studies; D004734:Energy Metabolism / Q000187:drug effects*; D005421:Flavoring Agents / Q000494:pharmacology; D064368:Healthy Volunteers; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009419:Nerve Tissue Proteins / Q000819:agonists; D010084:Oxidation-Reduction; D015398:Signal Transduction / Q000187:drug effects; D000074025:TRPA1 Cation Channel; D050053:TRPM Cation Channels / Q000819:agonists; D050916:TRPV Cation Channels / Q000819:agonists; D013817:Thermography; D050051:Transient Receptor Potential Channels / Q000819:agonists*; D055815:Young Adult
chemical_list: D015220:Calcium Channels; D005421:Flavoring Agents; D009419:Nerve Tissue Proteins; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050053:TRPM Cation Channels; C425966:TRPM8 protein, human; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D050051:Transient Receptor Potential Channels; D000171:Acrolein; D002211:Capsaicin; C012843:cinnamaldehyde