title: A case of neonatal lupus erythematosus in a very low-birth-weight infant that suffered intraventricular hemorrhage at birth.
abstract: This report describes the case of a very low-birth-weight male infant with neonatal lupus erythematosus. His mother had Sjögren's syndrome, and her previous child had suffered a complete heart block. Accordingly, maternal steroid (betamethasone) therapy was administered to prevent a congenital heart block for 15 weeks (from 13 to 27 weeks' gestation). At 28 weeks' gestation, the mother was weaned off the steroid therapy, and an emergency cesarean section was carried out at 29 weeks and 6 days' gestation because of a nonreassuring fetal status (NRFS). At birth, the infant exhibited grade-III intraventricular hemorrhage (IVH). Although it is unclear why the infant developed a NRFS and IVH, the condition of the fetus should be carefully monitored during and after long-term maternal steroid treatment.
authors.affiliation: a Department of Neonatology , Akita Red Cross Hospital , Akita , Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Arai
authors.affiliation: a Department of Neonatology , Akita Red Cross Hospital , Akita , Japan.
authors.forename: Hatsushi
authors.initials: H
authors.lastname: Nakajima
authors.affiliation: b Department of Pediatrics , Akita University Graduate School of Medicine , Akita , Japan , and.
authors.forename: Nao
authors.initials: N
authors.lastname: Ogino
authors.affiliation: a Department of Neonatology , Akita Red Cross Hospital , Akita , Japan.
authors.forename: Tomoo
authors.initials: T
authors.lastname: Ito
authors.affiliation: a Department of Neonatology , Akita Red Cross Hospital , Akita , Japan.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Goto
authors.affiliation: c Department of Obstetrics , Akita Red Cross Hospital , Akita , Japan.
authors.forename: Yurina
authors.initials: Y
authors.lastname: Kameta
authors.affiliation: c Department of Obstetrics , Akita Red Cross Hospital , Akita , Japan.
authors.forename: Natsuki
authors.initials: N
authors.lastname: Ono
authors.affiliation: c Department of Obstetrics , Akita Red Cross Hospital , Akita , Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Hosoya
authors.affiliation: c Department of Obstetrics , Akita Red Cross Hospital , Akita , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sanada
authors.affiliation: b Department of Pediatrics , Akita University Graduate School of Medicine , Akita , Japan , and.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D002543:Cerebral Hemorrhage / Q000209:etiology / Q000473:pathology*; D005260:Female; D005315:Fetal Diseases / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000151:congenital* / Q000209:etiology / Q000473:pathology; D008297:Male; D011247:Pregnancy; D012859:Sjogren's Syndrome / Q000150:complications / Q000473:pathology*
keywords: Maternal betamethasone therapy; Preterm infant; neonatal lupus erythematosus