title: Mesomeric configuration makes polyleucine micelle an optimal nanocarrier.
abstract: Micelle with mesomeric polyleucine (PDLLeu) core demonstrated the most uniform morphology, the smallest diameter and the highest drug loading capability compared to those with dextrorotatory (PDLeu), levorotatory (PLLeu) and racemic PLeu (PD/LLeu) cores. In addition, the modification with c(RGDfC) endowed the optimal PDLLeu micelle with enhanced intracellular drug release and cytotoxicity, indicating its great potential for targeted drug delivery.
authors.affiliation: Department of Chemical Engineering, Changchun University of Technology, Changchun 130012, P. R. China. yangyanan@ccut.edu.cn.
authors.forename: Taoyuan
authors.initials: T
authors.lastname: He
authors.forename: Di
authors.initials: D
authors.lastname: Li
authors.forename: Yanan
authors.initials: Y
authors.lastname: Yang
authors.forename: Jianxun
authors.initials: J
authors.lastname: Ding
authors.forename: Feng
authors.initials: F
authors.lastname: Jin
authors.forename: Xiuli
authors.initials: X
authors.lastname: Zhuang
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D010455:Peptides; C027819:polyleucine