title: High expression of dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1) is associated with poor prognosis in acute myeloid leukemia.
abstract: The purpose of this study was to investigate the expression status of Dual-Specificity Phosphatase 5 Pseudogene 1 (DUSP5P1) and its clinical relevance in patients with acute myeloid leukemia (AML). Real-time quantitative PCR (RQ-PCR) was performed to detect the status of DUSP5P1 expression in 89 patients with de novo AML and 24 normal controls. The level of DUSP5P1 expression was significantly up-regulated in AML compared to controls (P=0.031). The patients with high expression of DUSP5P1 had higher percentage of blasts in bone marrow (BM) than those without high expression (P=0.027). The occurrence rate of DUSP5P1 high expression was significantly higher in M1 (2/8, 25%) and M2 subtypes (9/33, 27%) than in M3 subtype (0/17, 0%) (P=0.034). At the same time, the frequency of DUSP5P1 high expression in patients with intermediate (13/53, 24%) and poor karyotypes (5/11, 45%) was significantly higher than that in patients with favorable karyotype (0/21, 0%) (P=0.003). Meanwhile, DUSP5P1 high-expressed patients had significantly shorter overall survival (OS) than those with low expression (median 4.5 vs. 10.5 months, respectively, P=0.038). Our findings indicated that high expression of DUSP5P1 may identify high-risk AML patients and is associated with poor prognosis in AML.
authors.affiliation: Department of Hematology, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China; Department of Laboratory Center, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China.
authors.forename: Ling-Yu
authors.initials: LY
authors.lastname: Zhou
authors.affiliation: Department of Hematology, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China; Department of Laboratory Center, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China.
authors.forename: Jia-Yu
authors.initials: JY
authors.lastname: Yin
authors.affiliation: Department of Laboratory Center, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China; Department of Hematology, The Affiliated Jintan Hospital of Jiangsu UniversityPeople's Republic of China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Department of Hematology, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China; Department of Laboratory Center, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Zhai
authors.affiliation: Department of Hematology, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China; Department of Laboratory Center, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China.
authors.forename: Tin-Juan
authors.initials: TJ
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China; Department of Laboratory Center, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Wang
authors.affiliation: Department of Hematology, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China; Department of Laboratory Center, The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002, Jiangsu, People's Republic of China.
authors.forename: Dong-Qin
authors.initials: DQ
authors.lastname: Yang
authors.affiliation: Department of Hematology, The Affiliated People's Hospital of Jiangsu University Zhenjiang 212002, Jiangsu, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
authors.affiliation: Department of Laboratory Center, The Affiliated People's Hospital of Jiangsu University Zhenjiang 212002, Jiangsu, People's Republic of China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Laboratory Center, The Affiliated People's Hospital of Jiangsu University Zhenjiang 212002, Jiangsu, People's Republic of China.
authors.forename: Zhao-Qun
authors.initials: ZQ
authors.lastname: Deng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology* / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011544:Pseudogenes / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor
keywords: DUSP5P1; Pseudogene; acute myeloid leukemia (AML); prognostic