title: Association of Polymorphisms in Intercellular Adhesion Molecule 1 (ICAM-1) Gene with Cancer Susceptibility: A Meta-Analysis of 14 Case-Control Studies.
abstract: BACKGROUND Many epidemiology studies have indicated that polymorphisms in ICAM-1 are associated with a variety of cancers, but published data are contradictory and inconclusive. Therefore, we conducted the current meta-analysis to elaborate the effects of ICAM-1 polymorphisms (rs5491, rs3093030, rs281432, and rs1799969) on cancer susceptibility. MATERIAL AND METHODS We conducted a comprehensive literature search in PubMed, Web of Science, and Google Scholar. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between ICAM-1 polymorphisms and cancer susceptibility. RESULTS We enrolled 14 published case-control studies including 4608 cancer cases and 4913 controls. We found an increased susceptibility of cancer in polymorphism rs1799969 (C vs. T: OR=1.662, 95%CI=1.288-2.143, p=0141; CT vs. TT: OR=1.860, 95%CI=1.398-2.474, p=0.507; CC+CT vs. TT: OR=1.812, 95%CI=1.373-2.391, p=0.284) of ICAM-1 among the overall population. However, no association between polymorphisms rs5491, rs3093030, or rs281432 of ICAM-1 and cancer susceptibility was identified. In the stratification analysis by ethnicity, we identified an increased susceptibility for Asians in rs3093030 polymorphism (CC vs. TC+TT: OR=1.728, 95% CI=1.234-2.421, p=0.787). CONCLUSIONS Our results suggest that the ICAM-1 polymorphism rs1799969 is significantly associated with increased susceptibility to overall cancer. Further studies (preferably prospective) are warranted to validate these relationships.
authors.affiliation: College of Life Science, University of Chinese Academy of Sciences, Beijing, China (mainland).
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: , Shenzhen University, Shenzhen, Guangdong, China (mainland).
authors.forename: Junjie
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Urology, Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, Guangdong, China (mainland).
authors.forename: Jian
authors.initials: J
authors.lastname: Bai
authors.affiliation: Department of Urology, Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, Guangdong, China (mainland).
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Urology, Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, Guangdong, China (mainland).
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Urology, Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, Guangdong, China (mainland).
authors.forename: Hongbing
authors.initials: H
authors.lastname: Mei
mesh_terms: D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias
chemical_list: D018799:Intercellular Adhesion Molecule-1