title: Serum Collagen Type II Cleavage Epitope and Serum Hyaluronic Acid as Biomarkers for Treatment Monitoring of Dogs with Hip Osteoarthritis.
abstract: The aim of this study was to evaluate the use of serum type II collagen cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring in osteoarthritic dogs. For this purpose, a treatment model based on mesenchymal stem cells derived from adipose tissue combined with plasma rich in growth factors was used. This clinical study included 10 dogs with hip osteoarthritis. Both analytes were measured in serum at baseline, just before applying the treatment, and 1, 3, and 6 months after treatment. These results were compared with those obtained from force plate analysis using the same animals during the same study period. Levels of type II collagen cleavage epitope decreased and those of hyaluronic acid increased with clinical improvement objectively verified via force plate analysis, suggesting these two biomarkers could be effective as indicators of clinical development of joint disease in dogs.
authors.affiliation: Departamento de Patología Animal, Universidad de las Palmas de Gran Canaria, Arucas, Las Palmas, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Vilar
authors.affiliation: Departamento Medicina y Cirugía Animal, Cátedra García Cugat, Universidad CEU Cardenal Herrera, Valencia, Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: Rubio
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Spinella
authors.affiliation: Departamento Medicina y Cirugía Animal, Cátedra García Cugat, Universidad CEU Cardenal Herrera, Valencia, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Cuervo
authors.affiliation: Departamento Medicina y Cirugía Animal, Cátedra García Cugat, Universidad CEU Cardenal Herrera, Valencia, Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Sopena
authors.affiliation: Artroscopia GC, Hospital Quirón, Barcelona, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: Cugat
authors.affiliation: Artroscopia GC, Hospital Quirón, Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Garcia-Balletbó
authors.affiliation: Departamento de Medicina y Cirugía Animal, Universidad de Córdoba, Córdoba, Spain.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Dominguez
authors.affiliation: Departamento de Medicina y Cirugía Animal, Universidad de Córdoba, Córdoba, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Granados
authors.affiliation: Departamento de Medicina y cirugía animal, Universidad de Murcia, Murcia, Spain.
authors.forename: Asta
authors.initials: A
authors.lastname: Tvarijonaviciute
authors.affiliation: Departamento de Medicina y cirugía animal, Universidad de Murcia, Murcia, Spain.
authors.forename: José J
authors.initials: JJ
authors.lastname: Ceron
authors.affiliation: Departamento Medicina y Cirugía Animal, Cátedra García Cugat, Universidad CEU Cardenal Herrera, Valencia, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Carrillo
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001696:Biomechanical Phenomena; D024043:Collagen Type II / Q000097:blood*; D004285:Dogs; D000939:Epitopes / Q000097:blood*; D005500:Follow-Up Studies; D006820:Hyaluronic Acid / Q000097:blood*; D015207:Osteoarthritis, Hip / Q000097:blood* / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*
chemical_list: D015415:Biomarkers; D024043:Collagen Type II; D000939:Epitopes; D006820:Hyaluronic Acid