title: Differentiating Between Cancer and Inflammation: A Metabolic-Based Method for Functional Computed Tomography Imaging.
abstract: One of the main limitations of the highly used cancer imaging technique, PET-CT, is its inability to distinguish between cancerous lesions and post treatment inflammatory conditions. The reason for this lack of specificity is that [(18)F]FDG-PET is based on increased glucose metabolic activity, which characterizes both cancerous tissues and inflammatory cells. To overcome this limitation, we developed a nanoparticle-based approach, utilizing glucose-functionalized gold nanoparticles (GF-GNPs) as a metabolically targeted CT contrast agent. Our approach demonstrates specific tumor targeting and has successfully distinguished between cancer and inflammatory processes in a combined tumor-inflammation mouse model, due to dissimilarities in angiogenesis occurring under different pathologic conditions. This study provides a set of capabilities in cancer detection, staging and follow-up, and can be applicable to a wide range of cancers that exhibit high metabolic activity.
authors.affiliation: Faculty of Engineering and the Institutes of Nanotechnology & Advanced Materials, Bar-Ilan University , Ramat-Gan 5290002, Israel.
authors.forename: Menachem
authors.initials: M
authors.lastname: Motiei
authors.affiliation: Faculty of Engineering and the Institutes of Nanotechnology & Advanced Materials, Bar-Ilan University , Ramat-Gan 5290002, Israel.
authors.forename: Tamar
authors.initials: T
authors.lastname: Dreifuss
authors.affiliation: Faculty of Engineering and the Institutes of Nanotechnology & Advanced Materials, Bar-Ilan University , Ramat-Gan 5290002, Israel.
authors.forename: Oshra
authors.initials: O
authors.lastname: Betzer
authors.affiliation: Faculty of Engineering and the Institutes of Nanotechnology & Advanced Materials, Bar-Ilan University , Ramat-Gan 5290002, Israel.
authors.forename: Hana
authors.initials: H
authors.lastname: Panet
authors.affiliation: Davidoff Cancer Center, Rabin Medical Center , Beilinson Campus, Petah Tiqwa 4941492, Israel.
authors.forename: Aron
authors.initials: A
authors.lastname: Popovtzer
authors.affiliation: Faculty of Engineering and the Institutes of Nanotechnology & Advanced Materials, Bar-Ilan University , Ramat-Gan 5290002, Israel.
authors.forename: Jordan
authors.initials: J
authors.lastname: Santana
authors.affiliation: Cyclotron-Radiochemistry-MicroPET Unit, Hadassah-Hebrew University Hospital , Jerusalem 91120, Israel.
authors.forename: Galith
authors.initials: G
authors.lastname: Abourbeh
authors.affiliation: Cyclotron-Radiochemistry-MicroPET Unit, Hadassah-Hebrew University Hospital , Jerusalem 91120, Israel.
authors.forename: Eyal
authors.initials: E
authors.lastname: Mishani
authors.affiliation: Faculty of Engineering and the Institutes of Nanotechnology & Advanced Materials, Bar-Ilan University , Ramat-Gan 5290002, Israel.
authors.forename: Rachela
authors.initials: R
authors.lastname: Popovtzer
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry* / Q000378:metabolism; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D005947:Glucose / Q000737:chemistry* / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D019788:Fluorodeoxyglucose F18; D006046:Gold; D005947:Glucose
keywords: CT; FDG-PET; cancer; gold nanoparticles; metabolic-based imaging