title: Alkyne Difunctionalization by Dual Gold/Photoredox Catalysis.
abstract: Highly selective tandem nucleophilic addition/cross-coupling reactions of alkynes have been developed using visible-light-promoted dual gold/photoredox catalysis. The simultaneous oxidation of Au(I) and coordination of the coupling partner by photo-generated aryl radicals, and the use of catalytically inactive gold precatalysts allows for high levels of selectivity for the cross-coupled products without competing hydrofunctionalization or homocoupling. As demonstrated in representative arylative Meyer-Schuster and hydration reactions, this work expands the scope of dual gold/photoredox catalysis to the largest class of substrates for gold catalysts and benefits from the mild and environmentally attractive nature of visible-light activation.
authors.affiliation: NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany.
authors.forename: Adrian
authors.initials: A
authors.lastname: Tlahuext-Aca
authors.affiliation: NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany.
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Hopkinson
authors.affiliation: NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany.
authors.forename: R Aleyda
authors.initials: RA
authors.lastname: Garza-Sanchez
authors.affiliation: NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany. glorius@uni-muenster.de.
authors.forename: Frank
authors.identifier: http://orcid.org/0000-0002-0648-956X
authors.initials: F
authors.lastname: Glorius
keywords: alkynes; arylation; diazonium salts; gold; synthetic methods