title: The efficacy of blueberry and grape seed extract combination on triple therapy for Helicobacter pylori eradication: a randomised controlled trial.
abstract: Helicobacter pylori is a major risk factor for gastritis, gastric ulcers and gastric cancer. Traditional therapy with proton pump inhibitor and antibiotics is regarded as optimal for H. pylori eradication whereas, the eradication rate is unsatisfactory. Studies have reported that cranberry may inhibit H. pylori adhesion to the human gastric mucus but lack of other berry extracts have been evaluated in clinical study. Thus, a 9-week add-on randomised controlled trial was conducted to explore the impact of blueberry and grape seed extract (BGE) combinations traditional therapy for H. pylori eradication. In results, we found that there was no significant difference of eradication rate between the berry extract group and placebo group in the intention-to-treat analysis and in the per-protocol analysis (94.64% versus 84.62%, p = 0.085). Diarrhoea, constipation and epigastric pain were observed increasing during ingestion of the berry extract in some cases. In conclusion, this study indicated that no significant difference existed between the BGE extract group and placebo group in eradication rate under triple therapy.
authors.affiliation: a School of Nutrition and Health Sciences , Taipei Medical University , Taipei , Taiwan ;|b Division of Gastroenterology, Department of Internal Medicine , Shin Kong Wu Ho-Su Memorial Hospital , Taipei , Taiwan ;|c Graduate Institute of Biomedical Informatics, Taipei Medical University , Taipei , Taiwan ;|d Department of Gastroenterology , Hospital Lam Wah Ee , Penang , Malaysia ;
authors.forename: Chian-Sem
authors.initials: CS
authors.lastname: Chua
authors.affiliation: e School of Medicine , Taipei Medical University , Taipei , Taiwan.
authors.forename: Kuo-Ching
authors.initials: KC
authors.lastname: Yang
authors.affiliation: b Division of Gastroenterology, Department of Internal Medicine , Shin Kong Wu Ho-Su Memorial Hospital , Taipei , Taiwan ;
authors.forename: Jui-Hao
authors.initials: JH
authors.lastname: Chen
authors.affiliation: b Division of Gastroenterology, Department of Internal Medicine , Shin Kong Wu Ho-Su Memorial Hospital , Taipei , Taiwan ;
authors.forename: Yuh-Hwa
authors.initials: YH
authors.lastname: Liu
authors.affiliation: b Division of Gastroenterology, Department of Internal Medicine , Shin Kong Wu Ho-Su Memorial Hospital , Taipei , Taiwan ;
authors.forename: Yi-Hsin
authors.initials: YH
authors.lastname: Hsu
authors.affiliation: a School of Nutrition and Health Sciences , Taipei Medical University , Taipei , Taiwan ;
authors.forename: Hsiu-Chuan
authors.initials: HC
authors.lastname: Lee
authors.affiliation: a School of Nutrition and Health Sciences , Taipei Medical University , Taipei , Taiwan ;
authors.forename: Shih-Yi
authors.initials: SY
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001422:Bacterial Adhesion; D029798:Blueberry Plants / Q000737:chemistry*; D017291:Clarithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D064098:Esomeprazole / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D056604:Grape Seed Extract / Q000737:chemistry / Q000494:pharmacology*; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D056604:Grape Seed Extract; D000658:Amoxicillin; D017291:Clarithromycin; D064098:Esomeprazole
keywords: Blueberry extract; Helicobacter pylori; grape seed extracts; polyphenol