title: Oroxylin A Inhibits Allergic Airway Inflammation in Ovalbumin (OVA)-Induced Asthma Murine Model.
abstract: Oroxylin A, a natural flavonoid isolated from the medicinal herb Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory property. In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. BABL/c mice were sensitized and airway-challenged with OVA to induce asthma. Oroxylin A (15, 30, and 60 mg/kg) was administered by oral gavage 1 h before the OVA treatment on day 21 to 23. The results showed that oroxylin A attenuated OVA-induced lung histopathologic changes, airway hyperresponsiveness, and the number of inflammatory cells. Oroxylin A also inhibited the levels of IL-4, IL-5, IL-13, and OVA-specific IgE in BALF. Furthermore, oroxylin A significantly inhibited OVA-induced NF-κB activation. In conclusion, these results suggested that oroxylin A inhibited airway inflammation in OVA-induced asthma murine model by inhibiting NF-κB activation. These results suggested that oroxylin A was a potential therapeutic drug for treating allergic asthma.
authors.affiliation: Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, 252000, Shandong, China.
authors.forename: De-Gang
authors.initials: DG
authors.lastname: Zhou
authors.affiliation: Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, 252000, Shandong, China.
authors.forename: Bao-Zhong
authors.initials: BZ
authors.lastname: Diao
authors.affiliation: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Academy of Chinese Medical Sciences), Guangzhou, 510006, Guangdong, China. zhouwenyl@sina.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Liaocheng City Food and Drug Inspection and Testing Center, Liaocheng, 252000, Shandong, China.
authors.forename: Jia-Long
authors.initials: JL
authors.lastname: Feng
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D004789:Enzyme Activation / Q000187:drug effects*; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use*; D007073:Immunoglobulin E / Q000276:immunology; D007249:Inflammation / Q000188:drug therapy; D018793:Interleukin-13 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D015848:Interleukin-5 / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D016328:NF-kappa B / Q000378:metabolism*; D010047:Ovalbumin; D028321:Plant Preparations / Q000494:pharmacology; D031364:Scutellaria baicalensis / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D018793:Interleukin-13; D015848:Interleukin-5; D016328:NF-kappa B; D028321:Plant Preparations; D015847:Interleukin-4; D007073:Immunoglobulin E; C080669:5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one; D010047:Ovalbumin
keywords: NF-κB; OVA; asthma; oroxylin A