title: Postoperative plasma 8-iso-prostaglandin F2α levels are associated with delirium and cognitive dysfunction in elderly patients after hip fracture surgery.
abstract: BACKGROUND
  Oxidative stress may be involved in occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD). 8-iso-Prostaglandin F2α (8-iso-PGF2α), an isoprostane derived from arachidonic acid via lipid peroxidation, is considered a gold standard for measuring oxidative stress. The present study aimed to investigate the ability of postoperative plasma 8-iso-PGF2α levels to predict POD and POCD in elderly patients undergoing hip fracture surgery.
  
  
  METHODS
  Postoperative plasma 8-iso-PGF2α levels of 182 patients were measured by an enzyme-linked immunosorbent assay. We assessed the relationships between plasma 8-iso-PGF2α levels and the risk of POD and POCD using a multivariate analysis.
  
  
  RESULTS
  Plasma 8-iso-PGF2α levels and age were identified as the independent predictors for POD and POCD. Based on areas under receiver operating characteristic curve, the predictive values of 8-iso-PGF2α were obviously higher than those of age for POD and POCD. In a combined logistic-regression model, 8-iso-PGF2α significantly enhanced the areas under curve of age for prediction of POD and POCD.
  
  
  CONCLUSIONS
  Postoperative plasma 8-iso-PGF2α levels may have the potential to predict POD and POCD in elder patients undergoing hip fracture surgery.
authors.affiliation: Department of Orthopedics, The People's Hospital of Wenzhou City, 57 Canghou Lane, Wenzhou 325000, China.
authors.forename: Yuan-Bo
authors.initials: YB
authors.lastname: Zheng
authors.affiliation: Department of Orthopedics, The People's Hospital of Wenzhou City, 57 Canghou Lane, Wenzhou 325000, China.
authors.forename: Guo-Mo
authors.initials: GM
authors.lastname: Ruan
authors.affiliation: Department of Orthopedics, The People's Hospital of Wenzhou City, 57 Canghou Lane, Wenzhou 325000, China.
authors.forename: Jia-Xing
authors.initials: JX
authors.lastname: Fu
authors.affiliation: Department of Orthopedics, The People's Hospital of Wenzhou City, 57 Canghou Lane, Wenzhou 325000, China.
authors.forename: Zhong-Liang
authors.initials: ZL
authors.lastname: Su
authors.affiliation: Department of Orthopedics, The People's Hospital of Wenzhou City, 57 Canghou Lane, Wenzhou 325000, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Cheng
authors.affiliation: Department of Orthopedics, The People's Hospital of Wenzhou City, 57 Canghou Lane, Wenzhou 325000, China. Electronic address: jianbogaohz@163.com.
authors.forename: Jian-Zuo
authors.initials: JZ
authors.lastname: Lu
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000097:blood*; D003693:Delirium / Q000097:blood*; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006620:Hip Fractures / Q000601:surgery*; D006801:Humans; D008297:Male; D011184:Postoperative Period
chemical_list: C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost
keywords: 8-iso-Prostaglandin F2α; Cognitive dysfunction; Delirium; Elderly; Hip fracture; Postoperative