title: Injectable micellar supramolecular hydrogel for delivery of hydrophobic anticancer drugs.
abstract: In this paper, an injectable micellar supramolecular hydrogel composed of α-cyclodextrin (α-CD) and monomethoxy poly(ethylene glycol)-b-poly(ε-caplactone) (MPEG5000-PCL5000) micelles was developed by a simple method for hydrophobic anticancer drug delivery. By mixing α-CD aqueous solution and MPEG5000-PCL5000 micelles, an injectable micellar supramolecular hydrogel could be formed under mild condition due to the inclusion complexation between α-CD and MPEG segment of MPEG5000-PCL5000 micelles. The resultant supramolecular hydrogel was thereafter characterized by X-ray diffraction (XRD) and Scanning electron microscopy (SEM). The effect of α-CD amount on the gelation time, mechanical strength and thixotropic property was studied by a rheometer. Payload of hydrophobic paclitaxel (PTX) to supramolecular hydrogel was achieved by encapsulation of PTX into MPEG5000-PCL5000 micelles prior mixing with α-CD aqueous solution. In vitro release study showed that the release behavior of PTX from hydrogel could be modulated by change the α-CD amount in hydrogel. Furthermore, such supramolecular hydrogel could enhance the biological activity of encapsulated PTX compared to free PTX, as indicated by in vitro cytotoxicity assay. All these results indicated that the developed micellar supramolecular hydrogel might be a promising injectable drug delivery system for anticancer therapy.
authors.affiliation: Department of Pharmacy, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
authors.forename: CuiXiang
authors.initials: C
authors.lastname: Fu
authors.affiliation: Department of Pharmacy, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
authors.forename: XiaoXiao
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Pharmacy, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Laboratory Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
authors.forename: XiaoQun
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye hospital, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
authors.forename: XingYi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pharmacy, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
authors.forename: ZhengFeng
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Pharmacy, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China. guang91_cn@126.com.
authors.forename: GuangYong
authors.initials: G
authors.lastname: Lin
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D007267:Injections; D008175:Lung Neoplasms; D008422:Materials Testing; D008823:Micelles; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D014961:X-Ray Diffraction; D047391:alpha-Cyclodextrins / Q000737:chemistry*
chemical_list: D000277:Adjuvants, Pharmaceutic; D000970:Antineoplastic Agents; D020100:Hydrogels; D008823:Micelles; D011091:Polyesters; D047391:alpha-Cyclodextrins; C439611:methoxy poly(ethylene glycol-co-epsilon-caprolactone); D011092:Polyethylene Glycols; C032613:alpha-cyclodextrin