title: Short-Term and Long-Term Reproducibility of Hypertension Phenotypes Obtained by Office and Ambulatory Blood Pressure Measurements.
abstract: The authors aimed to assess the reproducibility of normotension and white-coat, masked, and sustained hypertension in 839 untreated patients who underwent two separate assessments (median, 3; interquartile range, 0-13 months) by both office and ambulatory blood pressure (BP) monitoring (ABPM). The proportion of patients falling into the same category in the two assessments was: 52% normotension and 55% white-coat, 47% masked, and 82% sustained hypertension. The most frequent switch was to sustained hypertension (26% of white-coat and 33% of masked hypertension). No clinical factors predicted the change in category, except for higher office diastolic BP in patients with masked hypertension who developed sustained hypertension, compared with those who remained with masked hypertension (84±4 mm Hg vs 80±5 mm Hg; P=.006). The reproducibility of hypertension phenotypes was highly dependent on the time between assessments. The authors conclude that white-coat and masked hypertension phenotypes are only reproducible in the short-term, while they frequently shift towards sustained hypertension in the long-term.
authors.affiliation: Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona, Barcelona, Spain. adelasierra@mutuaterrassa.cat.
authors.forename: Alejandro
authors.initials: A
authors.lastname: de la Sierra
authors.affiliation: CAP la Mina, University of Barcelona, Barcelona, Spain.
authors.forename: Ernest
authors.initials: E
authors.lastname: Vinyoles
authors.affiliation: Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: José R
authors.initials: JR
authors.lastname: Banegas
authors.affiliation: Istituto Auxologico Italiano, University of Milano-Bicocca, Milan, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Parati
authors.affiliation: Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: de la Cruz
authors.affiliation: Department of Nephrology, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Gorostidi
authors.affiliation: Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain.
authors.forename: Julián
authors.initials: J
authors.lastname: Segura
authors.affiliation: Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Ruilope
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000145:classification*; D008297:Male; D059468:Masked Hypertension / Q000453:epidemiology*; D008875:Middle Aged; D010641:Phenotype; D015203:Reproducibility of Results; D012307:Risk Factors; D059466:White Coat Hypertension / Q000453:epidemiology*