title: Impact of Mean Platelet Volume on Long-Term Mortality in Chinese Patients with ST-Elevation Myocardial Infarction.
abstract: We investigated the association between mean platelet volume (MPV) and risk of all-cause mortality in Chinese patients with ST-Elevation Myocardial Infarction (STEMI). We enrolled 1836 patients with STEMI in Xuanwu Hospital from January 2008 to December 2013. Based on MPV, patients were categorized into the following groups: < 9.5 fL (n = 85), 9.5-11.0 fL (n = 776), 11.1-12.5 fL (n = 811) and >12.5 fL (n = 164), respectively. Mean duration of follow-up was 56.9 months, and 197 patients (10.7%) died during follow-up. All-cause mortality rates were compared between groups. The lowest mortality occurred in patients with MPV between 9.5-11.0 fL, with a multivariable-adjusted hazard ratio (HR) of 1.15(95%CI 0.62-1.50), 1.38(95%CI 1.20-1.68), and 1.72(95%CI 1.41-1.96) in patients with MPV of <.5, 11.1-12.5 and >12.5 fL, respectively. Therefore, increased MPV was associated with all-cause mortality in Chinese patients with STEMI. MPV might be useful as a marker for risk stratification in Chinese patients with STEMI.
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 100053.
authors.forename: Xi-peng
authors.initials: XP
authors.lastname: Sun
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 100053.
authors.forename: Bo-yu
authors.initials: BY
authors.lastname: Li
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 100053.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 100053.
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 100053.
authors.forename: Qi
authors.initials: Q
authors.lastname: Hua
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000166:cytology*; D002681:China; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000208:ethnology / Q000401:mortality*; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome