title: Spontaneous Pregnancy Following Ulipristal Acetate Treatment in a Woman with a Symptomatic Uterine Fibroid.
abstract: BACKGROUND
  Uterine fibroids (UFs) may impair fertility and promote miscarriage. The optimal treatment for women with UFs who wish to conceive is uncertain.
  
  
  METHODS
  A 35-year-old woman of African ancestry with a history of recurrent miscarriage (gravida 5, para 0) had a solitary submucosal UF (volume: 102.4 cm(3)) extending into the uterine cavity. Following a three-month course of ulipristal acetate (UPA) 5 mg daily, UF volume decreased to 72.1 cm(3). The patient conceived approximately two months after discontinuing UPA. She had an uncomplicated pregnancy and underwent a planned induction of labour at 38 weeks' gestation. The patient had a normal vaginal delivery of a healthy male infant weighing 3130 g. An ultrasound performed three months post-delivery revealed further reduction in UF volume to 14.5 cm(3).
  
  
  CONCLUSIONS
  This report demonstrates the utility of UPA in the management of women with UFs who desire pregnancy but who opt for non-surgical management.
authors.affiliation: Headwaters Health Care Centre, Orangeville, ON.
authors.forename: Khulood
authors.initials: K
authors.lastname: Murad
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology; D000328:Adult; D003270:Contraceptive Agents / Q000008:administration & dosage; D036861:Delivery, Obstetric / Q000379:methods; D005260:Female; D005306:Fertilization; D006801:Humans; D007889:Leiomyoma / Q000150:complications / Q000473:pathology / Q000628:therapy; D009649:Norpregnadienes / Q000008:administration & dosage*; D011247:Pregnancy; D011256:Pregnancy Outcome; D014594:Uterine Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy
chemical_list: D003270:Contraceptive Agents; D009649:Norpregnadienes; C555622:ulipristal acetate
keywords: fertility; medical treatment; pregnancy; submucosal; ulipristal acetate; uterine fibroids