title: Kawasaki disease and cardiovascular risk: a comprehensive review of subclinical vascular changes in the longer term.
abstract: Studies of subclinical vascular changes post-Kawasaki disease indicate that, in general, individuals with a history of coronary artery aneurysms have increased carotid intima-media thickness, evidence of endothelial dysfunction, and increased arterial stiffness, possibly indicative of heightened cardiovascular risk. The results are less consistent for low-risk groups.
  
  
  CONCLUSIONS
  Until data are available from larger prospective studies, it is prudent to advise families of individuals with a history of Kawasaki disease to minimise traditional modifiable cardiovascular risk factors.
authors.affiliation: Murdoch Childrens Research Institute, The Royal Children's Hospital, Melbourne, Vic., Australia.|Department of Paediatrics, The University of Melbourne, Parkville, Vic., Australia.|Department of General Medicine, The Royal Children's Hospital, Melbourne, Vic., Australia.
authors.forename: Katherine Y H
authors.initials: KY
authors.lastname: Chen
authors.affiliation: Murdoch Childrens Research Institute, The Royal Children's Hospital, Melbourne, Vic., Australia.|Department of Paediatrics, The University of Melbourne, Parkville, Vic., Australia.|Department of General Medicine, The Royal Children's Hospital, Melbourne, Vic., Australia.
authors.forename: Nigel
authors.initials: N
authors.lastname: Curtis
authors.affiliation: Division of Pediatric Cardiology, CHU Ste-Justine, University of Montreal, Montreal, QC, Canada.
authors.forename: Nagib
authors.initials: N
authors.lastname: Dahdah
authors.affiliation: Heart Research Group, Murdoch Childrens Research Institute and Department of Cardiology, The Royal Children's Hospital, Melbourne, Vic., Australia.
authors.forename: Remi
authors.initials: R
authors.lastname: Kowalski
authors.affiliation: Department of Paediatrics, The University of Melbourne, Parkville, Vic., Australia.|Heart Research Group, Murdoch Childrens Research Institute and Department of Cardiology, The Royal Children's Hospital, Melbourne, Vic., Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Cheung
authors.affiliation: Murdoch Childrens Research Institute, The Royal Children's Hospital, Melbourne, Vic., Australia.|Department of Paediatrics, The University of Melbourne, Parkville, Vic., Australia.|Department of Paediatrics, Monash University, Clayton, Vic, Australia.
authors.forename: David P
authors.initials: DP
authors.lastname: Burgner
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology*; D059168:Carotid Intima-Media Thickness; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors
keywords: Carotid intima-media thickness; Endothelial function; Kawasaki disease; Mucocutaneous lymph node syndrome; Vascular stiffness