title: Preparation of magnetic and pH-responsive chitosan microcapsules via sonochemical method.
abstract: Magnetic and pH-responsive chitosan microcapsules (MPRCMCs) were prepared by a simple sonochemical method. Superparamagnetic oleic acid modified Fe3O4 nanoparticles (OA-Fe3O4 NPs) and hydrophobic drugs could be directly loaded into MPRCMCs during sonication. The obtained microcapsules had a well-defined spherical morphology with the average size of 2 μm. The microcapsules showed an excellent magnetic property. In addition, the pH-responsive controlled release of coumarin 6 (C6) from MPRCMCs indicated that the developed microcapsules could be a promising candidate for drugs carriers.
authors.affiliation: a College of Chemistry , Jilin University , Changchun , P. R. China ;
authors.forename: Fengzhi
authors.initials: F
authors.lastname: Xu
authors.affiliation: a College of Chemistry , Jilin University , Changchun , P. R. China ;
authors.forename: Tianqi
authors.initials: T
authors.lastname: Zhao
authors.affiliation: b Department of Ophthalmology , The Second Hospital of Jilin University , Changchun , P. R. China.
authors.forename: Shurong
authors.initials: S
authors.lastname: Wang
authors.affiliation: a College of Chemistry , Jilin University , Changchun , P. R. China ;
authors.forename: Songfeng
authors.initials: S
authors.lastname: Liu
authors.affiliation: a College of Chemistry , Jilin University , Changchun , P. R. China ;
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.affiliation: a College of Chemistry , Jilin University , Changchun , P. R. China ;
authors.forename: Zhanfeng
authors.initials: Z
authors.lastname: Li
authors.affiliation: a College of Chemistry , Jilin University , Changchun , P. R. China ;
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wang
authors.affiliation: a College of Chemistry , Jilin University , Changchun , P. R. China ;
authors.forename: Xuejun
authors.initials: X
authors.lastname: Cui
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D003374:Coumarins / Q000008:administration & dosage; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D019301:Oleic Acid / Q000737:chemistry*; D010316:Particle Size; D013010:Sonication; D013844:Thiazoles / Q000008:administration & dosage
chemical_list: D003374:Coumarins; D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles; D013844:Thiazoles; C517282:coumarin 6; D019301:Oleic Acid; D048271:Chitosan
keywords: Drug delivery; chitosan; magnetic; microcapsules; pH-responsive; sonochemistry