title: Catalytic Selenium-Promoted Intermolecular Friedel-Crafts Alkylation with Simple Alkenes.
abstract: A method for conducting selenium-promoted intermolecular Friedel-Crafts (F-C) alkylation reactions has been developed with simple alkenes using trimethylsilyl trifluoromethanesulfonate as a catalyst and N-phenylselenophthalimide as an efficient selenium source. Electron-rich arenes smoothly underwent F-C alkylation with a variety of alkenes to afford alkylated products in good yield and with high regioselectivity and diastereoselectivity. The regioselectivity and stereoselectivity of arenes and alkenes as well as a preliminary mechanism of the F-C alkylation reaction are discussed.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University) Ministry of Education and ‡School of Chemical Science and Technology, Yunnan University , 2 Green Lake North Road, Kunming 650091, China.
authors.forename: E
authors.initials: E
authors.lastname: Tang
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University) Ministry of Education and ‡School of Chemical Science and Technology, Yunnan University , 2 Green Lake North Road, Kunming 650091, China.
authors.forename: Yinjiao
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University) Ministry of Education and ‡School of Chemical Science and Technology, Yunnan University , 2 Green Lake North Road, Kunming 650091, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University) Ministry of Education and ‡School of Chemical Science and Technology, Yunnan University , 2 Green Lake North Road, Kunming 650091, China.
authors.forename: Weilin
authors.initials: W
authors.lastname: Wang
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University) Ministry of Education and ‡School of Chemical Science and Technology, Yunnan University , 2 Green Lake North Road, Kunming 650091, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University) Ministry of Education and ‡School of Chemical Science and Technology, Yunnan University , 2 Green Lake North Road, Kunming 650091, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Dai