title: Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey.
abstract: Data on 68 146 hematopoietic stem cell transplants (HSCTs) (53% autologous and 47% allogeneic) gathered by 1566 teams from 77 countries and reported through their regional transplant organizations were analyzed by main indication, donor type and stem cell source for the year 2012. With transplant rates ranging from 0.1 to 1001 per 10 million inhabitants, more HSCTs were registered from unrelated 16 433 donors than related 15 493 donors. Grafts were collected from peripheral blood (66%), bone marrow (24%; mainly non-malignant disorders) and cord blood (10%). Compared with 2006, an increase of 46% total (57% allogeneic and 38% autologous) was observed. Growth was due to an increase in reporting teams (18%) and median transplant activity/team (from 38 to 48 HSCTs/team). An increase of 167% was noted in mismatched/haploidentical family HSCT. A Strengths, Weaknesses, Opportunities, Threats (SWOT) analysis revealed the global perspective of WBMT to be its major strength and identified potential to be the key professional body for patients and authorities. The limited data collection remains its major weakness and threat. In conclusion, global HSCT grows over the years without plateauing (allogeneic>autologous) and at different rates in the four World Health Organization regions. Major increases were observed in allogeneic, haploidentical HSCT and, to a lesser extent, in cord blood transplantation.
authors.affiliation: The Worldwide Network of Blood and Marrow Transplantation (WBMT) Transplant Activity Survey Office, University Hospital Basel, Basel, Switzerland.|Department of Hematology-Oncology, University Hospital, Leipzig, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Niederwieser
authors.affiliation: The Worldwide Network of Blood and Marrow Transplantation (WBMT) Transplant Activity Survey Office, University Hospital Basel, Basel, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Baldomero
authors.affiliation: The Australasian Bone Marrow Transplant Recipient Registry (ABMTRR), Royal Melbourne Hospital, Parkville, VIC, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Szer
authors.affiliation: Institute for Operations Research and Computational Finances, University of St Gallen, St Gallen, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Gratwohl
authors.affiliation: The Eastern Mediterranean Blood and Marrow Transplant Group (EMBMT), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors.forename: M
authors.initials: M
authors.lastname: Aljurf
authors.affiliation: Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Atsuta
authors.affiliation: The Latin American Blood and Marrow Transplant Group (LABMT), Instituto Nacional de Cancer, Rio de Janeiro, Brazil.
authors.forename: L F
authors.initials: LF
authors.lastname: Bouzas
authors.affiliation: National Marrow Donor Program, Minneapolis, MN, USA.
authors.forename: D
authors.initials: D
authors.lastname: Confer
authors.affiliation: Medical University of Graz, Division of Hematology, Graz, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Greinix
authors.affiliation: The Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: M
authors.initials: M
authors.lastname: Horowitz
authors.affiliation: The Asian Pacific Blood and Marrow Transplant Group (APBMT) Data Centre, Aichi Medical University, School of Medicine, Aichi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Iida
authors.affiliation: The Canadian Blood and Marrow Transplant Group (CBMTG), Princess Margaret Hospital, Toronto, ON, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Lipton
authors.affiliation: The European Blood and Marrow Transplant Group (EBMT), Hôpital St Antoine, St Antoine, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Mohty
authors.affiliation: The African Blood and Marrow Transplant Group (AFBMT), Johannesburg, South Africa.
authors.forename: N
authors.initials: N
authors.lastname: Novitzky
authors.affiliation: The World Health Organization WHO, Geneva, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Nunez
authors.affiliation: The Worldwide Network of Blood and Marrow Transplantation (WBMT) Transplant Activity Survey Office, University Hospital Basel, Basel, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Passweg
authors.affiliation: The Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Pasquini
authors.affiliation: Aichi Medical University, School of Medicine, Aichi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kodera
authors.affiliation: Department of Hematology, Hammersmith Hospital, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Apperley
authors.affiliation: Department of Pediatric, Hospital Samaritano, Sao Paulo, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Seber
authors.affiliation: The Worldwide Network of Blood and Marrow Transplantation (WBMT) Transplant Activity Survey Office, University Hospital Basel, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Gratwohl
mesh_terms: D016026:Bone Marrow Transplantation; D036101:Cord Blood Stem Cell Transplantation; D014943:Global Health / Q000706:statistics & numerical data*; D018380:Hematopoietic Stem Cell Transplantation / Q000706:statistics & numerical data*; D006801:Humans; D036102:Peripheral Blood Stem Cell Transplantation; D011795:Surveys and Questionnaires; D014019:Tissue Donors; D000075442:Transplantation, Haploidentical; D014184:Transplantation, Homologous