title: Extensive tumoral melanosis associated with ipilimumab-treated melanoma.
abstract: Tumoral melanosis describes a pigmented lesion clinically similar to melanoma but on histology reveals dense aggregates of melanin-laden, benign macrophages without malignant cells. In the few reported cases so far, tumoral melanosis has arisen in the skin or lymph node of a patient with a regressed melanoma or an epithelioid tumour. As a marker of regressed primary melanoma, its discovery may prompt investigation and surveillance for undiagnosed local or metastatic disease. Here, we present a unique case of extensive tumoral melanosis arising during ipilimumab treatment of in-transit metastases from a previously excised melanoma.
authors.affiliation: Division of Dermatology, Washington University in St. Louis, St. Louis, MO, U.S.A.
authors.forename: K
authors.initials: K
authors.lastname: Staser
authors.affiliation: Division of Dermatology, Washington University in St. Louis, St. Louis, MO, U.S.A.
authors.forename: D
authors.initials: D
authors.lastname: Chen
authors.affiliation: Division of Dermatology, Washington University in St. Louis, St. Louis, MO, U.S.A.|Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, U.S.A.
authors.forename: J
authors.initials: J
authors.lastname: Solus
authors.affiliation: Division of Dermatology, Washington University in St. Louis, St. Louis, MO, U.S.A.|Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, U.S.A.
authors.forename: I S
authors.initials: IS
authors.lastname: Rosman
authors.affiliation: Division of Dermatology, Washington University in St. Louis, St. Louis, MO, U.S.A.|Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, U.S.A.
authors.forename: A
authors.initials: A
authors.lastname: Schaffer
authors.affiliation: Division of Dermatology, Washington University in St. Louis, St. Louis, MO, U.S.A.
authors.forename: L
authors.initials: L
authors.lastname: Cornelius
authors.affiliation: Division of Hematology and Oncology, Washington University in St. Louis, St. Louis, MO, U.S.A.
authors.forename: G P
authors.initials: GP
authors.lastname: Linette
authors.affiliation: Department of Surgery, Washington University in St. Louis, St. Louis, MO, U.S.A.
authors.forename: R C
authors.initials: RC
authors.lastname: Fields
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D006801:Humans; D000074324:Ipilimumab; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D008548:Melanosis / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D012086:Reoperation; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D000074324:Ipilimumab