title: Müllerian intra-abdominal carcinomatosis in hereditary breast ovarian cancer syndrome: implications for risk-reducing surgery.
abstract: More than 40 years ago Lynch et al. described several multigenerational breast cancer family pedigrees which demonstrated autosomal dominant inheritance of a trait(s) that increased risks for both breast and ovarian cancers. Mutation carriers in at least 90 % of these hereditary breast ovarian cancer (HBOC) syndrome families have been linked to cancer-associated mutations in the genes BRCA1 and BRCA2. This review focuses on the contributions of Lynch, colleagues and collaborators and pertinent literature, toward defining the HBOC syndrome, the cancer risks that the inherited adverse mutations convey, the gynecologic tissues and organs from which the malignancy may arise to disseminate throughout the pelvic and abdominal organs and peritoneum and how this information can be used to reduce the risk and morbidities of intra-abdominal carcinomatosis in effected individuals.
authors.affiliation: Departments of Obstetrics and Gynecology and Preventive Medicine, Creighton University School of Medicine, 601 N. 30th Street, Omaha, NE, 68131, USA. mjcasey@creighton.edu.
authors.forename: Murray Joseph
authors.initials: MJ
authors.lastname: Casey
authors.affiliation: Department of Pathology, Creighton University School of Medicine and CHI Health Creighton University Medical Center - Bergan Mercy, Omaha, NE, USA.
authors.forename: Agnes B
authors.initials: AB
authors.lastname: Colanta
mesh_terms: D000008:Abdominal Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein / Q000235:genetics; D002277:Carcinoma / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D020022:Genetic Predisposition to Disease; D061325:Hereditary Breast and Ovarian Cancer Syndrome / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D018200:Mixed Tumor, Mullerian / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D009154:Mutation; D010052:Ovariectomy; D000072036:Prophylactic Mastectomy; D065286:Prophylactic Surgical Procedures / Q000379:methods*; D058994:Salpingectomy
chemical_list: D019313:BRCA1 Protein; D024682:BRCA2 Protein; C551750:BRCA2 protein, human
keywords: Hereditary breast ovarian cancer; Intra-abdominal carcinomatosis; Risk-reducing surgery