title: Yes associated protein is a poor prognostic factor in well-differentiated lung adenocarcinoma.
abstract: The Hippo pathway is a highly conserved potent regulator of cell growth and apoptosis including large tumor suppressor (LATS) and Yes-associated protein (YAP). LATS has been regarded as a tumor suppressor gene and YAP as either of a tumor suppressor gene or an oncogene. We investigated their expression in lung adenocarcinoma. YAP and LATS protein expression was assessed in 167 surgically resected lung adenocarcinomas and compared with clinicopathologic factors. Disease free survival and overall survival were also evaluated. YAP expression was noted in cytoplasm (48 cases; 28.7%), nuclear (34; 20.4%) and both locations (4; 2.4%). The nuclear expression was typically observed in well differentiated adenocarcinoma. LATS was expressed in cytoplasm when its signal is weak. Perinuclear expression of LATS was observed when it is strongly expressed. While cytoplasmic and nuclear YAP expressions were inversely related. In well differentiated adenocarcinoma patients, YAP nuclear expression was related with more frequent relapse. Both of nuclear YAP and LATS expression were more frequently observed in well differentiated adenocarcinoma. Furthermore, YAP expression exhibited more frequent relapse in well differentiated adenocarcinoma group. We suggest that YAP may act as an oncogene and predict poorer prognosis in well differentiated lung adenocarcinoma.
authors.affiliation: Departmet of Internal Medicine, School of Medicine, Pusan National University Yangsan, Korea.
authors.forename: Mi Hyun
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Departmet of Pathology, School of Medicine, Pusan National University Yangsan, Korea.
authors.forename: Young Keum
authors.initials: YK
authors.lastname: Kim
authors.affiliation: Departmet of Pathology, School of Medicine, Pusan National University Yangsan, Korea.
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Shin
authors.affiliation: Departmet of Pathology, School of Medicine, Pusan National University Yangsan, Korea.
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Departmet of Pathology, School of Medicine, Pusan National University Yangsan, Korea.
authors.forename: Nari
authors.initials: N
authors.lastname: Shin
authors.affiliation: Departmet of Pathology, School of Medicine, Pusan National University Yangsan, Korea.
authors.forename: Arong
authors.initials: A
authors.lastname: Kim
authors.affiliation: Departmet of Pathology, School of Medicine, Pusan National University Yangsan, Korea.
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Departmet of Pathology, School of Medicine, Pusan National University Yangsan, Korea.
authors.forename: Kyung Un
authors.initials: KU
authors.lastname: Choi
authors.affiliation: Departmet of Pathology, School of Medicine, Pusan National University Yangsan, Korea.
authors.forename: Jee Yeon
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Departmet of Pathology, School of Medicine, Pusan National University Yangsan, Korea.
authors.forename: Chang Hun
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Departmet of Pathology, School of Medicine, Pusan National University Yangsan, Korea.
authors.forename: Mee Young
authors.initials: MY
authors.lastname: Sol
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000032:analysis*; D000230:Adenocarcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000737:chemistry; D003593:Cytoplasm / Q000737:chemistry; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015513:Oncogene Proteins / Q000032:analysis*; D010750:Phosphoproteins / Q000032:analysis*; D012307:Risk Factors; D013997:Time Factors; D014157:Transcription Factors; D016896:Treatment Outcome; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; D015513:Oncogene Proteins; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human
keywords: LATS; Lung; YAP; adenocarcinoma; hippo pathway