title: Therapeutic vaccines for prostate cancer: recent advances and future directions.
abstract: In recent years, therapeutic cancer vaccines have emerged as a viable and promising treatment for prostate cancer. Beyond sipuleucel-T, phase III trials are evaluating multiple vaccine platforms in men with this disease. Growing data evaluating vaccine therapies suggests that these agents are more effective in patients with more indolent and possibly also earlier stages of disease. In addition, a wealth of preclinical data has shown that traditional prostate cancer treatments including anti androgens, cytotoxic and radiation therapies may provide immunologic synergy when given in combination with vaccine platforms. Building off this data, numerous clinical trials are evaluating therapeutic cancer vaccines in early stage prostate cancer and also in combination with traditional prostate cancer therapies. In addition, in order to optimize immune responses, ongoing trials are evaluating vaccines in combination with immune checkpoint inhibitors. Preliminary data from these trials have been promising and are offering an exciting glimpse at the future of immunotherapy for this disease.
authors.affiliation: a Genitourinary Malignancies Branch, Center for Cancer Research , National Cancer Institute , Bethesda , MD , USA.
authors.forename: Julius
authors.initials: J
authors.lastname: Strauss
authors.affiliation: a Genitourinary Malignancies Branch, Center for Cancer Research , National Cancer Institute , Bethesda , MD , USA.
authors.forename: Ravi A
authors.initials: RA
authors.lastname: Madan
mesh_terms: D019496:Cancer Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D017326:Clinical Trials, Phase III as Topic; D003131:Combined Modality Therapy; D055808:Drug Discovery / Q000639:trends*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000628:therapy*; D055502:Secondary Prevention; D016896:Treatment Outcome
chemical_list: D019496:Cancer Vaccines
keywords: Immunotherapy; Prostate Cancer; Vaccines