title: Thrombopoietic status of patients on haemodialysis.
abstract: Thrombocytopenia is a potential dialysis-related treatment complication. Developments in bio-compatible dialyser membranes have decreased the occurrence of thrombocytopenia. We investigated whether thrombopoiesis is impaired in haemodialysis patients by measuring the thrombopoietin level and absolute immature platelet number (AIPN) in the blood of patients undergoing haemodialysis. Samples were collected from the dialysis tubing pre- and post- haemodialysis in a cohort of 45 well-characterized haemodialysis patients. Thrombopoietin levels and AIPN increased following haemodialysis, despite no change in platelet count. Observed increase in release of immature platelets from the bone marrow following haemodialysis indicates possible complement activation secondary to interaction between blood constituents and the dialysis membrane.
authors.affiliation: Western Reserve Health Education, Northeastern Ohio Medical University (NEOMED), Youngstown, OH, USA.
authors.forename: Taha
authors.initials: T
authors.lastname: Bat
authors.affiliation: Western Reserve Health Education, Northeastern Ohio Medical University (NEOMED), Youngstown, OH, USA.
authors.forename: Betul E
authors.initials: BE
authors.lastname: Bat
authors.affiliation: Western Reserve Health Education, Northeastern Ohio Medical University (NEOMED), Youngstown, OH, USA.
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Moghraby
authors.affiliation: Western Reserve Health Education, Northeastern Ohio Medical University (NEOMED), Youngstown, OH, USA.
authors.forename: Samir
authors.initials: S
authors.lastname: Patel
authors.affiliation: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Xingmin
authors.initials: X
authors.lastname: Feng
authors.affiliation: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Cynthia E
authors.initials: CE
authors.lastname: Dunbar
authors.affiliation: Western Reserve Health Education, Northeastern Ohio Medical University (NEOMED), Youngstown, OH, USA.
authors.forename: Erdal
authors.initials: E
authors.lastname: Sarac
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D010979:Platelet Function Tests / Q000379:methods; D006435:Renal Dialysis / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology*; D034061:Thrombopoiesis / Q000502:physiology*; D013926:Thrombopoietin / Q000097:blood
chemical_list: D013926:Thrombopoietin
keywords: IL1A (IL1α); absolute immature platelet number; haemodialysis; immature platelet fraction; thrombopoietin