title: Hydrodynamics Analysis and CFD Simulation of Portal Venous System by TIPS and LS.
abstract: In cirrhotic patients, portal hypertension is often associated with a hyperdynamic changes. Transjugular Intrahepatic Portosystemic Shunt (TIPS) and Laparoscopic splenectomy are both treatments for liver cirrhosis due to portal hypertension. While, the two different interventions have different effects on hemodynamics after operation and the possibilities of triggering PVT are different. How hemodynamics of portal vein system evolving with two different operations remain unknown. Based on ultrasound and established numerical methods, CFD technique is applied to analyze hemodynamic changes after TIPS and Laparoscopic splenectomy. In this paper, we applied two 3-D flow models to the hemodynamic analysis for two patients who received a TIPS and a laparoscopic splenectomy, both therapies for treating portal hypertension induced diseases. The current computer simulations give a quantitative analysis of the interplay between hemodynamics and TIPS or splenectomy. In conclusion, the presented computational model can be used for the theoretical analysis of TIPS and laparoscopic splenectomy, clinical decisions could be made based on the simulation results with personal properly treatment.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhou
authors.forename: Yaozhen
authors.initials: Y
authors.lastname: Huang
authors.forename: Piyun
authors.initials: P
authors.lastname: Gong
authors.forename: Bing
authors.initials: B
authors.lastname: Peng
authors.forename: Shichun
authors.initials: S
authors.lastname: Zhou
mesh_terms: D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D057446:Hydrodynamics; D006975:Hypertension, Portal / Q000209:etiology / Q000601:surgery*; D010535:Laparoscopy; D008103:Liver Cirrhosis / Q000150:complications / Q000601:surgery*; D019168:Portasystemic Shunt, Transjugular Intrahepatic; D013156:Splenectomy