title: [Evaluation of the blood flow in common hepatic tumors by multi-slice spiral CT whole-liver perfusion imaging].
abstract: OBJECTIVE
  To study the characteristics of blood flow in common hepatic tumors by 256-slice spiral CT whole-liver perfusion imaging.
  
  
  METHODS
  Seventy-one patients with hepatic tumors were examined retrospectively by 256-slice spiral CT whole-liver perfusion. Among them, twenty-seven cases were of primary hepatic cancer, twenty-four cases of hepatic hemangioma, and twenty cases of hepatic metastases.Regions of interest (ROIs) were placed in the tumor parenchyma (Area A), peritumoral hepatic parenchyma (Area B), and normal hepatic parenchyma (Area C), respectively. The time density curves (TDC) were drawn, and perfusion parameters including hepatic arterial perfusion(HAP), portal venous perfusion(PVP), total liver perfusion(TLP) and hepatic erfusion index(HPI) were obtained. The values of ROIs were measured, and the perfusion parameters in the areas A, B, C of different hepatic tumors were statistically analyzed.
  
  
  RESULTS
  The values of HAP, PVP, HPI in the tumor parenchyma of primary hepatic carcinoma were (20.00 ± 11.41)ml · min(-1) · 100 ml(-1,) (32.31 ± 21.06)ml · min(-1) · 100 ml(-1,) (52.31 ± 30.55)ml · min(-1) · 100 ml(-1,) and (39.67 ± 11.19)%, showing significant difference as compared with those in peritumoral hepatic parenchyma and in normal hepatic parenchyma(P<0.05). The values of HAP, TLP, and HPI in the tumor parenchyma of hepatic hemangioma were (40.39 ± 29.23)ml · min(-1) · 100 ml(-1,) (132.72 ± 132.65) ml · min(-1) · 100 ml(-1,) and (35.51 ± 15.12)%, were significantly different as compared with those in the peritumoral hepatic parenchyma and in normal hepatic parenchyma(P<0.05). The values of HAP, PVP, HPI in the tumor parenchyma of hepatic metastases were (17.43 ± 12.27)ml · min(-1) · 100 ml(-1,) (36.19 ± 34.99) ml · min(-1) · 100 ml(-1,) and (37.86 ± 14.49)%, significantly different as compared normal hepatic parenchyma (P<0.05). The HAP, PVP, and TLP of tumor tissue and the PVP and HPI of peritumoral tissue in different hepatic tumors were statistically significantly different (P<0.05).
  
  
  CONCLUSIONS
  The multi-slice spiral CT whole-liver perfusion has certain value in the diagnosis of common hepatic tumors. Perfusion parameters in different areas of common hepatic tumors have their own hemodynamic characteristics.
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing 210000, China.
authors.forename: Mengdi
authors.initials: M
authors.lastname: Li
authors.affiliation: Email: chenyong6981@sina.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhiling
authors.initials: Z
authors.lastname: Gao
authors.forename: Kai
authors.initials: K
authors.lastname: Zhu
authors.forename: Xin
authors.initials: X
authors.lastname: Yin
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000000981:diagnostic imaging; D006391:Hemangioma / Q000098:blood supply* / Q000000981:diagnostic imaging; D006499:Hepatic Artery / Q000000981:diagnostic imaging / Q000502:physiology; D006801:Humans; D008099:Liver / Q000098:blood supply; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000556:secondary; D055420:Perfusion Imaging; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000502:physiology; D012039:Regional Blood Flow; D012189:Retrospective Studies; D036542:Tomography, Spiral Computed