title: Transformation from atypical chronic myeloid leukemia to chronic myelomonocytic leukemia as progression of myeloid neoplasm with platelet-derived growth factor ß rearrangement.
abstract: Myeloid neoplasms associated with platelet-derived growth factor b (PDGFRB) rearrangement usually keep only one morphologic type unless blast crisis. We describe a unique case of hematological features transformation from atypical chronic myeloid leukemia to chronic myelomonocytic leukemia, and imatinib showed no clinical therapeutic effects. The phenomenon indicates that different types of myeloid neoplasms associated with PDGFRB rearrangement can transform into one another with the progression of the disease, and to some extent, this transformation suggests the aggravation of disease.
authors.forename: Xue
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Haematology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Su
authors.forename: Chunting
authors.initials: C
authors.lastname: Zhao
authors.forename: Xianqi
authors.initials: X
authors.lastname: Feng
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D018450:Disease Progression; D015321:Gene Rearrangement; D006801:Humans; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000150:complications* / Q000235:genetics / Q000473:pathology; D015477:Leukemia, Myelomonocytic, Chronic / Q000209:etiology / Q000473:pathology*; D008297:Male; D011379:Prognosis; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000235:genetics*
chemical_list: D020797:Receptor, Platelet-Derived Growth Factor beta