title: Total Synthesis of (-)-Chromodorolide B.
abstract: The first total synthesis of a chromodorolide diterpenoid is described. The synthesis features a bimolecular radical addition/cyclization/fragmentation cascade that unites butenolide and trans-hydrindane fragments while fashioning two C-C bonds and stereoselectively forming three of the ten contiguous stereocenters of chromodorolide B.
authors.affiliation: Department of Chemistry, 1102 Natural Sciences II, University of California , Irvine, California 92697-2025, United States.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Tao
authors.affiliation: Department of Chemistry, 1102 Natural Sciences II, University of California , Irvine, California 92697-2025, United States.
authors.forename: Yuriy
authors.initials: Y
authors.lastname: Slutskyy
authors.affiliation: Department of Chemistry, 1102 Natural Sciences II, University of California , Irvine, California 92697-2025, United States.
authors.forename: Larry E
authors.initials: LE
authors.lastname: Overman
mesh_terms: D003500:Cyclization; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation
chemical_list: D004224:Diterpenes; C000612622:chromodorolide B