title: Decreased Hemolysis and Improved Hemodynamic Performance of Synchronized Bileaflet Mechanical Valve.
abstract: OBJECTIVE
  This study compared the performance of a newly patented synchronized valve (SV) with that of a commercially available (CAV) bileaflet mechanical heart valve.
  
  
  METHODS
  A high-speed camera was used to record the leaflet kinematics of the SV vs the CAV along the flow channel. Transvalvular energy loss, effective orifice area, and hemolysis ratios were obtained using a mock circulatory system at two fixed pulse rates and at various cardiac outputs with a fixed aortic pressure.
  
  
  RESULTS
  The rotational radius and inertia of the SV was lower than that of the CAV during valve closure. For heart rates and at cardiac outputs of 7, 5, and 4 L/min, the ratio of total energy loss to effective energy of the SV was significantly less than the CAV, whereas the effective orifice area of the SV was significantly larger than that of CAV. The hemolysis ratio after 4 hours was significantly higher in the CAV than in the SV for both pulse rates.
  
  
  CONCLUSIONS
  The synchronized leaflet motion mitigated leaflet rebound and regurgitation during valve closure, which could decrease energy loss, increase the effective orifice area, and reduce hemolysis.
authors.affiliation: Department of Mechanical & Mechatronic Engineering, National Taiwan Ocean University, Keelung, Taiwan, Republic of China; Center for Marine Mechatronic Systems, National Taiwan Ocean University, Keelung, Taiwan, Republic of China.
authors.forename: Chau-Chang
authors.initials: CC
authors.lastname: Chou
authors.affiliation: Department of Mechanical & Mechatronic Engineering, National Taiwan Ocean University, Keelung, Taiwan, Republic of China; Division of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan, Republic of China.
authors.forename: Te-Chun
authors.initials: TC
authors.lastname: Wu
authors.affiliation: Division of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan, Republic of China.
authors.forename: Hong-Yen
authors.initials: HY
authors.lastname: Liang
authors.affiliation: Department of Systems Engineering & Naval Architecture, National Taiwan Ocean University, Keelung, Taiwan, Republic of China.
authors.forename: Yi-Chih
authors.initials: YC
authors.lastname: Chow
authors.affiliation: Division of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan, Republic of China; College of Medicine, Chang Gung University, Tao-Yuan, Taiwan, Republic of China. Electronic address: yehccl@cgmh.org.tw.
authors.forename: Chi-Hsiao
authors.initials: CH
authors.lastname: Yeh
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan, Republic of China; College of Medicine, Chang Gung University, Tao-Yuan, Taiwan, Republic of China.
authors.forename: Wen-Jin
authors.initials: WJ
authors.lastname: Cherng
mesh_terms: D001021:Aortic Valve / Q000601:surgery*; D001696:Biomechanical Phenomena; D001705:Bioprosthesis; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006439:Hemodynamics / Q000502:physiology; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D008422:Materials Testing; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012680:Sensitivity and Specificity