title: The Role of Hypothalamic Neuropeptides in Neurogenesis and Neuritogenesis.
abstract: The hypothalamus is a source of neural progenitor cells which give rise to different populations of specialized and differentiated cells during brain development. Newly formed neurons in the hypothalamus can synthesize and release various neuropeptides. Although term neuropeptide recently undergoes redefinition, small-size hypothalamic neuropeptides remain major signaling molecules mediating short- and long-term effects on brain development. They represent important factors in neurite growth and formation of neural circuits. There is evidence suggesting that the newly generated hypothalamic neurons may be involved in regulation of metabolism, energy balance, body weight, and social behavior as well. Here we review recent data on the role of hypothalamic neuropeptides in adult neurogenesis and neuritogenesis with special emphasis on the development of food intake and social behavior related brain circuits.
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia; Institute of Physiology, Faculty of Medicine, Comenius University, Sasinkova 2, 813 72 Bratislava, Slovakia.
authors.forename: Jan
authors.initials: J
authors.lastname: Bakos
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia; Institute of Physiology, Faculty of Medicine, Comenius University, Sasinkova 2, 813 72 Bratislava, Slovakia.
authors.forename: Martina
authors.initials: M
authors.lastname: Zatkova
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia; Department of Normal and Pathological Physiology, Faculty of Medicine, Slovak Medical University, Limbova 12, 833 03 Bratislava, Slovakia.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Bacova
authors.affiliation: Institute of Physiology, Faculty of Medicine, Comenius University, Sasinkova 2, 813 72 Bratislava, Slovakia.
authors.forename: Daniela
authors.initials: D
authors.lastname: Ostatnikova
mesh_terms: D000818:Animals; D004435:Eating / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000166:cytology* / Q000502:physiology*; D058953:Neural Stem Cells / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology*
chemical_list: D009479:Neuropeptides