title: Eyelid fat grafting: Indications, operative technique and complications; a systematic review.
abstract: BACKGROUND
  Many recent studies concerning autologous fat grafting in the eyelids have been published, mostly consisting of case reports and retrospective case series. However, no study on the overall complication or satisfaction rate associated with the various grafting techniques exists. We performed a comprehensive literature review to determine the outcomes and complications of eyelid fat grafting, as well as patient satisfaction.
  
  
  METHODS
  A systematic review of the literature using the PRISMA criteria was conducted. This protocol was registered at the Prospective Register of Systematic Reviews at the National Institute for Health Research.
  
  
  RESULTS
  Sixteen studies, representing 1,159 patients and published between June 2004 and December 2014, were included. Satisfactory results, judged by clinical examination, were observed in all studies. Few postoperative complications were reported.
  
  
  CONCLUSIONS
  We demonstrated that the procedures were easy to perform, and achieved satisfactory and sustainable results with few complications in both reconstructive and cosmetic surgery. However, a wide disparity exists in the various fat harvesting, fat purification, and reinjection techniques. Further studies are required to assess the long-term outcomes. Our conclusions should be accepted cautiously due to the small number of articles and the lack of evidence in published studies.
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Hospital Sud, University of Rennes 1, Rennes, France; Department of Ophthalmology, Pontchaillou Hospital, University of Rennes 1, Rennes, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Boureaux
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Rangueil Hospital, Toulouse, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Chaput
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Hospital Sud, University of Rennes 1, Rennes, France.
authors.forename: Sahar
authors.initials: S
authors.lastname: Bannani
authors.affiliation: Department of Plastic and Reconstructive Surgery, Lapeyronie Burn Center, CHU of Montpellier, Montpellier, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Herlin
authors.affiliation: Department of Maxillofacial, Plastic, Reconstructive and Cosmetic Surgery, CHU of Nancy, Nancy, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: De Runz
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Hospital Sud, University of Rennes 1, Rennes, France.
authors.forename: Raphael
authors.initials: R
authors.lastname: Carloni
authors.affiliation: Department of Ophthalmology, Pontchaillou Hospital, University of Rennes 1, Rennes, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Mortemousque
authors.affiliation: Department of Ophthalmology, Pontchaillou Hospital, University of Rennes 1, Rennes, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Mouriaux
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Hospital Sud, University of Rennes 1, Rennes, France; INSERM U917, University of Rennes 1, Rennes, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Watier
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Hospital Sud, University of Rennes 1, Rennes, France; INSERM U917, University of Rennes 1, Rennes, France; SITI Laboratory, Etablissement Français du Sang Bretagne, Rennes University Hospital, Rennes, France; Stromalab Laboratory, UMR5273 CNRS/UPS/EFS - INSERM U1031, Rangueil Hospital, Toulouse, France. Electronic address: nbertheuil@gmail.com.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bertheuil
mesh_terms: D000273:Adipose Tissue / Q000601:surgery / Q000637:transplantation*; D005143:Eyelids / Q000601:surgery*; D006801:Humans; D017060:Patient Satisfaction; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D020858:Tissue and Organ Harvesting; D014182:Transplantation, Autologous
keywords: Adipose-derived stem cell; Eyelid; Facial rejuvenation; Fat grafting; Fat transplantation; Lipofilling