title: A peptide hydrogel derived from a fragment of human cardiac troponin C.
abstract: The human cardiac troponin C peptide fragment H-V(9)EQLTEEQKNEFKAAFDIFVLGA(31)-OH, which covers helix-A in the native protein, self-assembles into β-sheet fibrils in solution. These fibrils further entangle to give a hydrogel. This peptide may therefore serve as a template for development of novel biomaterials.
authors.affiliation: School of Biological Sciences, The University of Auckland, 3 Symonds St, Auckland, New Zealand. l.deleon@auckland.ac.nz m.brimble@auckland.ac.nz.
authors.forename: Luis M
authors.initials: LM
authors.lastname: De Leon-Rodriguez
authors.affiliation: School of Chemical Sciences, The University of Auckland, 23 Symonds St, Auckland, New Zealand.
authors.forename: Meder
authors.initials: M
authors.lastname: Kamalov
authors.affiliation: School of Chemical Sciences, The University of Auckland, 23 Symonds St, Auckland, New Zealand.
authors.forename: Yacine
authors.initials: Y
authors.lastname: Hemar
authors.affiliation: School of Biological Sciences, The University of Auckland, 3 Symonds St, Auckland, New Zealand. l.deleon@auckland.ac.nz m.brimble@auckland.ac.nz.
authors.forename: Alok K
authors.initials: AK
authors.lastname: Mitra
authors.affiliation: School of Chemistry, Food Science and Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AF, UK.
authors.forename: Valeria
authors.initials: V
authors.lastname: Castelletto
authors.affiliation: European Synchrotron Radiation Laboratory (ESRF), Grenoble, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hermida-Merino
authors.affiliation: School of Chemistry, Food Science and Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AF, UK.
authors.forename: Ian W
authors.initials: IW
authors.lastname: Hamley
authors.affiliation: School of Biological Sciences, The University of Auckland, 3 Symonds St, Auckland, New Zealand. l.deleon@auckland.ac.nz m.brimble@auckland.ac.nz.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Brimble
mesh_terms: D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D017433:Protein Structure, Secondary; D019209:Troponin C / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D010446:Peptide Fragments; D010455:Peptides; D019209:Troponin C; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate