title: Anti-obesity effects of artificial planting blueberry (Vaccinium ashei) anthocyanin in high-fat diet-treated mice.
abstract: This study aimed to evaluate the anti-obesity effects of artificial planting blueberry (Vaccinium ashei) anthocyanin (BA) in high-fat diet-induced obese male C57BL/6 mice. BA at doses of 50, 100, and 200 mg/kg was supplemented in the daily food of obese C57BL/6 mice during an 8-week experiment. Our findings indicate that consumption of BA at high doses reduced body weight by 19.4%, whereas both low and middle doses did not affect the body weight. Furthermore, BA supplementation at high dose could effectively decrease serum glucose, attenuate epididymal adipocytes, improve lipid profiles, and significantly down-regulate expression levels of TNFα, IL-6 PPARγ, and FAS genes. Therefour, BA might alter bodyweight by suppressing fatty acid synthesis and alleviating inflammation.
authors.affiliation: a Key Laboratory of Food Nutrition and Safety (Tianjin University of Science and Technology), Ministry of Education , Tianjin , PR China ;|b Department of Food Science and Nutrition , Zhejiang University , Hangzhou , China ;
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.affiliation: a Key Laboratory of Food Nutrition and Safety (Tianjin University of Science and Technology), Ministry of Education , Tianjin , PR China ;
authors.forename: Zenghong
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: a Key Laboratory of Food Nutrition and Safety (Tianjin University of Science and Technology), Ministry of Education , Tianjin , PR China ;
authors.forename: Jinjin
authors.initials: J
authors.lastname: Yin
authors.affiliation: c National Engineering Laboratory of Southwest Endangered Medicinal Resources Development , Guangxi Botanical Garden of Medicinal Plants , Nanning , China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Long
authors.affiliation: b Department of Food Science and Nutrition , Zhejiang University , Hangzhou , China ;
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D029798:Blueberry Plants / Q000737:chemistry*; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000096:biosynthesis; D005786:Gene Expression Regulation / Q000187:drug effects; D007249:Inflammation / Q000378:metabolism; D007783:Lactones / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000139:chemically induced / Q000517:prevention & control*; D000077403:Orlistat; D011897:Random Allocation
chemical_list: D000872:Anthocyanins; D004041:Dietary Fats; D005227:Fatty Acids; D007783:Lactones; D000077403:Orlistat
keywords: Anthocyanin; artificial planting blueberry; high-fat diet; obesity