title: Implication of immunokine profiling for cancer staging.
abstract: Tumor may arise from the dysregulation of immune system, which plays pivotal roles in counteracting tumor colonization, late-stage tumors, and metastases. In the midst of the establishment of cancer in vivo, immune cells are activated to release a multitude of immunokines, such as cytokines, and chemokines. Thus, since cytokine levels in tumor bearing host would be differential among local (intratumoral lesion, peritumoral normal tissue), and systemic sample site (serum), these differences might be significantly correlated to prognosis and treatment outcome for cancer patients. Previously, despite small number of patients, we demonstrated the feasibility of this proposition via only cytokine profiling. Based on this, herein we propose that immunokine profiling would be used as a surrogate, predictive tool for cancer staging, and progression.
authors.affiliation: Department of Radiation Oncology, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
authors.forename: Kawngwoo
authors.initials: K
authors.lastname: Park
authors.affiliation: Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
authors.forename: Madhusmita
authors.initials: M
authors.lastname: Dhupal
authors.affiliation: Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
authors.forename: Cheol-Su
authors.initials: CS
authors.lastname: Kim
authors.affiliation: Department of Microbiology and Institute for Clinical and Translational Research, Catholic Kwandong University College of Medicine, Gangneung 25601, Republic of Korea.
authors.forename: Yoon-Sun
authors.initials: YS
authors.lastname: Park
authors.affiliation: Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea; Institute of Genomic Cohort, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea. Electronic address: kim6@yonsei.ac.kr.
authors.forename: Soo-Ki
authors.initials: SK
authors.lastname: Kim
mesh_terms: D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D007107:Immune System; D007249:Inflammation; D008962:Models, Theoretical; D009367:Neoplasm Staging / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis* / Q000276:immunology*; D011379:Prognosis; D059016:Tumor Microenvironment
chemical_list: D018925:Chemokines; D016207:Cytokines