title: Is Celiac Disease an Etiological Factor in Children With Migraine?
abstract: To determine the prevalence of celiac disease in children and adolescents with migraine, the authors investigated serum levels of tissue transglutaminase antibody immunoglobulin A and total immunoglobulin A from 81 children with migraine and in a healthy control group of 176 children. Study participants who were positive for tissue transglutaminase immunoglobulin A antibodies underwent a duodenal biopsy. Two patients in the migraine group (2.5%) and 1 in the control group (0.57%) tested positive for serum tissue transglutaminase immunoglobulin A antibodies (P > .05). Duodenal biopsy did not confirm celiac disease in both groups, and these patients were considered "potential celiac" cases. In the present study, children with migraine did not exhibit a higher prevalence rate of celiac disease compared with healthy controls. Therefore, the screening test for celiac disease is not a necessary part of the management of migraine in children.
authors.affiliation: Department of Pediatrics, Division of Pediatric Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey oyabalci@yahoo.com.
authors.forename: Oya
authors.initials: O
authors.lastname: Balcı
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, Keçiören Training and Research Hospital, Ankara, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Yılmaz
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, Baskent University Medical Faculty, Ankara, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Sezer
authors.affiliation: Department of Pediatrics, Division of Pediatric Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey.
authors.forename: Şamil
authors.initials: Ş
authors.lastname: Hızlı
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002446:Celiac Disease / Q000097:blood* / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D004386:Duodenum / Q000473:pathology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D008881:Migraine Disorders / Q000097:blood* / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D011503:Transglutaminases / Q000097:blood / Q000276:immunology
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007070:Immunoglobulin A; D011503:Transglutaminases
keywords: celiac disease; children; migraine