title: Psychotropic Activity of New Fluorinated Derivatives of Tetrahydrocarbasoles.
abstract: Psychotropic properties of CA-7043× and CA-7050×, new fluorinated derivatives of tetrahydrocarbasoles, were examined on outbred CD1 mice and transgenic 5×FAD mice with Alzheimer disease. Both agents exerted cognitive-stimulating and anxiolytic effects in a dose of 5 mg/kg. In the new cage test, they retarded extinction of orientation and exploratory behavior. CA-7043× produced an anxiolytic effect on CD1 mice assessed in the open-field test and exerted cognitive-stimulating action in the new location test. In the same tests, CA-7050× demonstrated the cognitive-stimulating and anxiolytic effects on transgenic 5×FAD mice.
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia. nikolaevans@bk.ru.
authors.forename: N S
authors.initials: NS
authors.lastname: Nikolaeva
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.
authors.forename: V B
authors.initials: VB
authors.lastname: Sokolov
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Aksinenko
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.
authors.forename: R K
authors.initials: RK
authors.lastname: Ovchinnikov
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.
authors.forename: S O
authors.initials: SO
authors.lastname: Bachurin
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Kinzirskii
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy*; D001522:Behavior, Animal / Q000187:drug effects*; D002227:Carbazoles / Q000494:pharmacology*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects*; D006845:Hydrocarbons, Fluorinated / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D008822:Mice, Transgenic; D011619:Psychotropic Drugs / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; C000612726:CA-7043; C000612727:CA-7050; D002227:Carbazoles; D006845:Hydrocarbons, Fluorinated; D011619:Psychotropic Drugs
keywords: behavioral tests; cognitive-stimulating action; fluorinated derivatives of tetrahydrocarbasoles; transgenic mice