title: Gersemiols A-C and Eunicellol A, Diterpenoids from the Arctic Soft Coral Gersemia fruticosa.
abstract: Three new diterpenes named gersemiols A-C (1-3) and a new eunicellane diterpene, eunicellol A (4), have been isolated together with the known sesquiterpene (+)-α-muurolene (5) from the Arctic soft coral Gersemia fruticosa. The name gersemiane was assigned to the rare and unnamed diterpene skeleton of compounds 1-3 corresponding to 4-isopropyl-1,5,8a-trimethyltetradecahydrophenanthrene. The chemical structures were elucidated on the basis of extensive spectroscopic analysis (HR-ESIMS, 1D and 2D NMR) as well as coupling constant calculations for the determination of the relative configurations. All compounds were tested for their antimicrobial activity against several bacteria and fungi and eunicellol A was found to exhibit moderate and selective antibacterial activity.
authors.affiliation: University of Barcelona , Department of Animal Biology (Invertebrates), Faculty of Biology, Biodiversity Research Institute (IrBIO), Av. Diagonal 643, 08028 Barcelona, Catalonia, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Angulo-Preckler
authors.affiliation: Université Paris Descartes , Laboratoire de Pharmacognosie et de Chimie des Substances Naturelle, COMETE UMR 8638 CNRS, 75270 CEDEX 06 Paris, France.
authors.forename: Grégory
authors.initials: G
authors.lastname: Genta-Jouve
authors.affiliation: National University of Ireland Galway , School of Chemistry, Marine Biodiscovery, University Road, Galway, Ireland.
authors.forename: Nipun
authors.initials: N
authors.lastname: Mahajan
authors.affiliation: Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda. del Conocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Armilla, Granada, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: de la Cruz
authors.affiliation: Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda. del Conocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Armilla, Granada, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: de Pedro
authors.affiliation: Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda. del Conocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Armilla, Granada, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Reyes
authors.affiliation: University of Alaska Fairbanks , School of Fisheries and Ocean Science, Fairbanks Alaska 99775, United States.
authors.forename: Katrin
authors.initials: K
authors.lastname: Iken
authors.affiliation: University of Barcelona , Department of Animal Biology (Invertebrates), Faculty of Biology, Biodiversity Research Institute (IrBIO), Av. Diagonal 643, 08028 Barcelona, Catalonia, Spain.
authors.forename: Conxita
authors.initials: C
authors.lastname: Avila
authors.affiliation: National University of Ireland Galway , School of Chemistry, Marine Biodiscovery, University Road, Galway, Ireland.|Geoazur, UMR Université Nice Sophia Antipolis-CNRS-IRD-OCA, 250 rue Albert Einstein, 06560 Valbonne, France.
authors.forename: Olivier P
authors.initials: OP
authors.lastname: Thomas
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D004224:Diterpenes; D012717:Sesquiterpenes; C000610558:eunicellol A; C000610555:gersemiol A; C000610556:gersemiol B; C000610557:gersemiol C