title: Bipolar Depression and Cognitive Impairment: Shared Mechanisms and New Treatment Avenues.
abstract: Depression and cognitive impairment are pervasive and highly disabling aspects of bipolar disorder. Although cognitive impairment is partially independent from mood episodes, depressive symptoms may increase the risk of cognitive impairment in bipolar disorder through inflammatory processes as well as health risks such as obesity and sedentary behavior. Novel treatment avenues at the intersection of bipolar depression and cognitive impairment target inflammation directly or indirectly health behaviors such as diet, physical activity, and sleep hygiene.
authors.affiliation: Department of Psychiatry, UC San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Desert-Pacific Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA. Electronic address: cdepp@ucsd.edu.
authors.forename: Colin A
authors.initials: CA
authors.lastname: Depp
authors.affiliation: Department of Psychiatry, UC San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; SDSU-UCSD Joint Doctoral Program, Clinical Psychology, San Diego, CA, USA.
authors.forename: Sheena
authors.initials: S
authors.lastname: Dev
authors.affiliation: Department of Psychiatry, UC San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Desert-Pacific Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.
authors.forename: Lisa T
authors.initials: LT
authors.lastname: Eyler
mesh_terms: D000375:Aging; D001714:Bipolar Disorder / Q000150:complications* / Q000188:drug therapy; D003072:Cognition Disorders / Q000523:psychology* / Q000628:therapy; D015444:Exercise; D015438:Health Behavior; D006801:Humans; D009484:Neuropsychology
keywords: Aging; Brain function; Health behavior; Mood disorders; Neuropsychology