title: Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study.
abstract: BACKGROUND
  There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects.
  
  
  RESULTS
  Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile birth weight subgroups revealed markers associated with birth weight (ETs, MMP-9, VEGF, and 8-isoPGF-2α) and gestational age (ET-1, MMP-2, and VEGF).
  
  
  CONCLUSIONS
  Mechanistic insights into adverse birth outcome pathways can be achieved by integrating information on multiple biomarkers, physiology using systems biology approach.
authors.affiliation: a Analytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
authors.forename: Premkumari
authors.initials: P
authors.lastname: Kumarathasan
authors.affiliation: b Inhalation Toxicology Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
authors.forename: Renaud
authors.initials: R
authors.lastname: Vincent
authors.affiliation: a Analytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Bielecki
authors.affiliation: a Analytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
authors.forename: Erica
authors.initials: E
authors.lastname: Blais
authors.affiliation: a Analytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
authors.forename: Katrin
authors.initials: K
authors.lastname: Blank
authors.affiliation: a Analytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
authors.forename: Dharani
authors.initials: D
authors.lastname: Das
authors.affiliation: b Inhalation Toxicology Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
authors.forename: Subramanian
authors.initials: S
authors.lastname: Karthikeyan
authors.affiliation: c Population Studies Division, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada , and.
authors.forename: Sabit
authors.initials: S
authors.lastname: Cakmak
authors.affiliation: c Population Studies Division, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada , and.
authors.forename: Mandy
authors.initials: M
authors.lastname: Fisher
authors.affiliation: c Population Studies Division, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada , and.
authors.forename: Tye
authors.initials: T
authors.lastname: Arbuckle
authors.affiliation: d Department of Obstetrics and Gynecology , University of Sherbrooke , Sherbrooke , QC , Canada.
authors.forename: William
authors.initials: W
authors.lastname: Fraser
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001724:Birth Weight; D028441:F2-Isoprostanes / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D018384:Oxidative Stress; D011247:Pregnancy; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D015415:Biomarkers; D028441:F2-Isoprostanes; D042461:Vascular Endothelial Growth Factor A; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9
keywords: Gestational age; infant birth weight; maternal plasma biomarkers; oxidative stress; vascular function