title: Maintenance of the Cardiovascular Function in a Deeply Cooled Homeothermic Organism by Physiological Methods without External Rewarming.
abstract: Gradual cooling of homeothermic organisms is followed by slowing and arrest of breathing and heart contractions. During deep cooling, even relatively slight artificial ventilation decreases the lower temperature limit of life (by 4.5-5°C) and provides minimum oxygen supply to the heart and whole body. This allows us to restore cardiovascular function and prevent animal death after lethal cooling without eternal warming.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. kpivanov@nc2490.spb.edu.
authors.forename: K P
authors.initials: KP
authors.lastname: Ivanov
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: N K
authors.initials: NK
authors.lastname: Arokina
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D001833:Body Temperature Regulation; D002320:Cardiovascular Physiological Phenomena; D003080:Cold Temperature; D007036:Hypothermia, Induced / Q000379:methods*; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D051381:Rats; D012121:Respiration, Artificial / Q000379:methods*
keywords: breathing; heart contractions; hypothermia; hypoxia