title: Advances in the Treatment of Neuropathic Pain.
abstract: Neuropathic pain is pain that arises as a direct consequence of a lesion or diseases affecting the somatosensory system. Treatments for neuropathic pain include pharmacological, nonpharmacological, and interventional therapies. Currently recommended first-line pharmacological treatments include antidepressants and anticonvulsants (gabapentin and pregabalin). However, in some cases, pharmacological therapy alone fails to give adequate control of the chronic pain. New techniques have been invented and have been proved effective on neuropathic pain, such as behavioral, cognitive, integrative, and physical therapies. In this review, we focused on the advances in the treatment of central neuropathic pain, diabetic peripheral neuropathy, postherpetic neuralgia, and cancer pain.
authors.affiliation: Department of Anesthesiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yuguan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. garybeijing@163.com.
authors.forename: Yuguang
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D000072716:Cancer Pain / Q000503:physiopathology / Q000628:therapy; D059333:Central Nervous System Sensitization / Q000502:physiology; D059350:Chronic Pain / Q000188:drug therapy / Q000628:therapy; D015928:Cognitive Behavioral Therapy; D003929:Diabetic Neuropathies / Q000503:physiopathology / Q000628:therapy; D004599:Electric Stimulation Therapy; D005544:Forecasting; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy / Q000628:therapy*; D051474:Neuralgia, Postherpetic / Q000503:physiopathology / Q000628:therapy; D015213:Neuroimmunomodulation / Q000502:physiology; D026741:Physical Therapy Modalities; D061208:Pulsed Radiofrequency Treatment; D035703:Therapies, Investigational
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D000928:Antidepressive Agents
keywords: Anticonvulsant; Antidepressant; Neural stimulation; Neuropathic pain; Radio frequency