title: Light-Harvesting Photosensitizers for Photodynamic Inactivation of Bacteria under Both Visible and Near-Infrared Excitations.
abstract: We report a hybrid singlet oxygen production system, where strong resonance coupling between plasmonic nanoparticles and photosensitizing molecules results in exceptionally high singlet oxygen production under both visible light and near-infrared light excitation, even for the photosensitizing molecules without near-infrared absorption. The light-harvesting property of the plasmon-photosensitizer hybrids leads to an enhanced, broad-spectrum photodynamic inactivation of bacteria under a wide range of excitations, including that with near-infrared light.
authors.affiliation: Department of Chemistry, University of Cincinnati, Cincinnati, OH, 45221, USA.|School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Hu
authors.affiliation: Department of Chemistry, University of Cincinnati, Cincinnati, OH, 45221, USA.
authors.forename: Xian
authors.initials: X
authors.lastname: Cao
authors.affiliation: Department of Chemistry, University of Cincinnati, Cincinnati, OH, 45221, USA.
authors.forename: Ms Tevhide Ozkaya
authors.initials: MT
authors.lastname: Ahmadov
authors.affiliation: Department of Chemistry, University of Cincinnati, Cincinnati, OH, 45221, USA.
authors.forename: Rui
authors.initials: R
authors.lastname: Ding
authors.affiliation: Drug Discovery Center, University of Cincinnati, Cincinnati, OH, 45237, USA. tangho@ucmail.uc.edu.
authors.forename: Hong
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Chemistry, University of Cincinnati, Cincinnati, OH, 45221, USA. zhangph@ucmail.uc.edu.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D007259:Infrared Rays; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects*; D012256:Riboflavin / Q000737:chemistry / Q000494:pharmacology*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000737:chemistry; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D012834:Silver; D012256:Riboflavin
keywords: light-harvesting; photodynamic inactivation; riboflavin; silver nanoparticles; singlet oxygen