title: Intrajejunal infusion of 2-monoacylglycerol reduced food intake without inducing diarrhea in rats.
abstract: Some nutrients, such as carbohydrate, fat and protein, are known to stimulate satiety. However, the effect of sn-2-monoacylglycerol (2-MG), one of the digestive products of triglycerides, on food intake is still unclear. In the present study, the effects of 2-MG on food intake and diarrhea were evaluated and compared with long-chain fatty acid (LCFA) in rats by intrajejunal infusion. Intrajejunal infusion of 2-MG reduced food intake. In addition, 2-MG did not induce diarrhea at the condition that it comparably reduced food intake as compared with LCFA. These results suggest that 2-MG stimulates satiety without inducing diarrhea, different from LCFA.
authors.affiliation: Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan. Electronic address: Chihiro.okuma@jt.com.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Okuma
authors.affiliation: Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohta
authors.affiliation: Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ito
authors.affiliation: Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Tadaki
authors.affiliation: Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Oda
authors.affiliation: Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kume
authors.affiliation: Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Nishiu
authors.affiliation: Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kakutani
mesh_terms: D000818:Animals; D003864:Depression, Chemical; D003967:Diarrhea / Q000209:etiology*; D004435:Eating / Q000187:drug effects*; D005227:Fatty Acids / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology; D007583:Jejunum; D008297:Male; D050178:Monoglycerides / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D017207:Rats, Sprague-Dawley; D012527:Satiation / Q000187:drug effects*; D013268:Stimulation, Chemical
chemical_list: D005227:Fatty Acids; D050178:Monoglycerides
keywords: Diarrhea; Food intake; Monoacylglycerol