title: The impact of diabetes mellitus on the survival of patients with acromegaly.
abstract: BACKGROUND
  An increased risk of mortality in patients with uncontrolled acromegaly has been reported in several studies. We aimed to assess the impact of co-morbidities on the survival of patients with acromegaly after long-term treatment and follow-up.
  
  
  METHODS
  A retrospective analysis was performed for 285 patients with active acromegaly, who were admitted to the Chang Gung Memorial Hospital, Taiwan between 1978 and 2012. Of these patients, 106 (37.2%) were diagnosed with diabetes mellitus (DM). During the follow-up period, 21 cases of histological proved malignant in acromegalic patients, and DM with acromegaly had a higher incidence of malignancy (13.2% vs. 3.8%; p < 0.01). The 5-, 10-, and 20-year survival rates were 93.1%, 86.9%, and 84.7% for the DM group, respectively, and 96.5%, 96.5%, and 96.5% for the non-DM group, respectively. After a mean follow-up of 15.1 ± 0.6 years, age, DM, coronary heart disease, and malignancy were found to be significant factors of mortality. Control of growth hormone and IGF-1 levels also conferred a marginal survival benefit.
  
  
  CONCLUSIONS
  DM and malignancy significantly influence the survival of patients with acromegaly; thus, these patients need close follow-up and appropriate therapy. (Endokrynol Pol 2016; 67 (5): 501-506).
authors.forename: Chiou
authors.initials: C
authors.lastname: Wen-Ko
authors.forename: Chen
authors.initials: C
authors.lastname: Szu-Tah
authors.forename: Liu
authors.initials: L
authors.lastname: Feng-Hsuan
authors.forename: Chang
authors.initials: C
authors.lastname: Chen-Nen
authors.forename: Wang
authors.initials: W
authors.lastname: Ming-Hsu
authors.affiliation: Department of Industrial Design, Healthy Aging Research Centre, Chang Gung University, Taiwan. einjd@adm.cgmh.org.tw.
authors.forename: Lin
authors.initials: L
authors.lastname: Jen-Der
mesh_terms: D000172:Acromegaly / Q000453:epidemiology* / Q000401:mortality; D000328:Adult; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000401:mortality; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality; D012189:Retrospective Studies
keywords: IGF-1; co-morbidities; malignancy