title: Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature.
abstract: A stable and isolable difluoromethyl zinc reagent has been prepared through the reaction of ICF2H with diethyl zinc and DMPU. This new zinc reagent is a free-flowing solid and can be used in combination with a nickel catalyst to difluoromethylate aryl iodides, bromides, and triflates at room temperature. Such mild conditions for the catalytic difluoromethylation of these substrates are unprecedented.
authors.affiliation: Department of Chemistry, Lehigh University , 6 East Packer Avenue, Bethlehem, Pennsylvania 18015, United States.
authors.forename: Long
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Chemistry, Lehigh University , 6 East Packer Avenue, Bethlehem, Pennsylvania 18015, United States.
authors.forename: David A
authors.initials: DA
authors.lastname: Vicic