title: Impact of Elevated Hemoglobin and Serum Protein on Vasovagal Reaction from Blood Donation.
abstract: We conducted a cross-sectional study to elucidate factors contributing to vasovagal reaction (VVR), the most frequent side effect following whole blood and apheresis donations. Complications recorded at the collection sites after voluntary donations by the Japanese Red Cross Tokyo Blood Center (JRC), in the 2006 and 2007 fiscal years, were analyzed by both univariate analysis and the multivariate conditional logistic regression model. Of 1,119,716 blood donations over the full two years, complications were recorded for 13,320 donations (1.18%), among which 67% were VVR. There were 4,303 VVR cases which had sufficient information and could be used for this study. For each VVR case, two sex- and age-matched controls (n = 8,606) were randomly selected from the donors without complications. Age, sex, body mass index (BMI), predonation blood pressure, pulse and blood test results, including total protein, albumin, and hemoglobin, were compared between the VVR group and the control group. In univariate analysis, the VVR group was significantly younger, with a lower BMI, higher blood pressure and higher blood protein and hemoglobin levels than the control group (p<0.001). Furthermore, blood protein and hemoglobin levels showed dose-dependent relationships with VVR incidences by the Cochran-Armitage trend test (p<0.01). For both sexes, after adjusting for confounders with the multivariate conditional logistic regression model, the higher than median groups for total protein (male: OR 1.97; 95%CI 1.76,-2.21; female: OR 2.29; 95%CI 2.05-2.56), albumin (male: 1.75; 1.55-1.96; female: 1.76; 1.57-1.97) and hemoglobin (male: 1.98; 1.76-2.22; female: 1.62; 1.45-1.81) had statistically significant higher risk of VVR compared to the lower than median groups. These elevated serum protein and hemoglobin levels might offer new indicators to help understand VVR occurrence.
authors.affiliation: Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Koto-ku, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Odajima
authors.affiliation: The Japanese Red Cross Society, Minato-ku, Tokyo, Japan.
authors.forename: Minoko
authors.initials: M
authors.lastname: Takanashi
authors.affiliation: Department of Sports and Health Science, Daito Bunka University, Higashimatsuyama, Saitama, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sugimori
authors.affiliation: Department of Sports and Health Science, Daito Bunka University, Higashimatsuyama, Saitama, Japan.
authors.forename: Taiko
authors.initials: T
authors.lastname: Tanba
authors.affiliation: Department of Haematology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yoshinaga
authors.affiliation: Department of Haematology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.
authors.forename: Toshiko
authors.initials: T
authors.lastname: Motoji
authors.affiliation: Department of Sports and Health Science, Daito Bunka University, Higashimatsuyama, Saitama, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Munakata
authors.affiliation: Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Koto-ku, Tokyo, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nakajima
authors.affiliation: Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Koto-ku, Tokyo, Japan.
authors.forename: Mutsuhiko
authors.initials: M
authors.lastname: Minami
mesh_terms: D000328:Adult; D001782:Blood Donors; D001794:Blood Pressure; D001798:Blood Proteins; D016022:Case-Control Studies; D005260:Female; D006454:Hemoglobins; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012737:Sex Factors; D019462:Syncope, Vasovagal / Q000097:blood* / Q000209:etiology*; D055815:Young Adult
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins