title: Improved sensitivity via layered-double-hydroxide-uniformity-dependent chemiluminescence.
abstract: In the last two decades nanoparticles have been widely applied to enhance chemiluminescence (CL). The morphology of nanoparticles has an important influence on nanoparticle-amplified CL. However, studies of nanoparticle-amplified CL focus mainly on the size and shape effects, and no attempt has been made to explore the influence of uniformity in nanoparticle-amplified CL processes. In this study we have investigated nanoparticle uniformity in the luminol-H2O2CL system using layered double hydroxides (LDHs) as a model material. The results demonstrated that the uniformity of LDHs played a key role in CL amplification. A possible mechanism is that LDHs with high uniformity possess abundant catalytic active sites, which results in high CL intensity. Meanwhile, the sensitivity for H2O2detection was increased by one order of magnitude (1.0 nM). Moreover, the uniform-LDH-amplified luminol CL could be applied to selective detection of glucose in human plasma samples. Furthermore, such a uniformity-dependent CL enhancement effect could adapted to other redox CL systems-for example, the peroxynitrous acid (ONOOH) CL system.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, `100029, China.
authors.forename: Zenghe
authors.initials: Z
authors.lastname: Li
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, `100029, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, `100029, China.
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, `100029, China. luchao@mail.buct.edu.cn.
authors.forename: Chao
authors.initials: C
authors.lastname: Lu
mesh_terms: D001681:Biological Assay; D001786:Blood Glucose / Q000032:analysis*; D002384:Catalysis; D005949:Glucose Oxidase / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis*; D006878:Hydroxides / Q000737:chemistry*; D008163:Luminescent Measurements; D008165:Luminol / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010316:Particle Size; D030421:Peroxynitrous Acid / Q000737:chemistry; D012680:Sensitivity and Specificity; D012996:Solutions
chemical_list: D001786:Blood Glucose; D006878:Hydroxides; D012996:Solutions; D030421:Peroxynitrous Acid; D008165:Luminol; D006861:Hydrogen Peroxide; D005949:Glucose Oxidase
keywords: Chemiluminescence; Layered double hydroxides; Nanoparticle; Uniformity