title: Age and total and free prostate-specific antigen levels for predicting prostate volume in patients with benign prostatic hyperplasia.
abstract: OBJECTIVE
  To investigate the predictive values of free prostate-specific antigen (fPSA), total PSA (tPSA) and age on the prostate volume.
  
  
  METHODS
  The data of 2148 patients with lower urinary tract symptoms were analyzed retrospectively. The patients who had transrectal ultrasonography guided 10 core biopsies owing to the findings obtained on digital rectal examination and presence of high PSA levels (PSA = 2.5-10 ng/dl), and proven to have BPH histopathologically were included in the study. Age, tPSA, fPSA and the prostate volumes (PV) of the patients were noted.
  
  
  RESULTS
  One thousand patients that fulfilled the inclusion criteria were included in the study. The PV of the patients were significantly correlated with age, tPSA and fPSA (p < 0.001 and r = 0.307, p < 0.001 and r = 0.382, p < 0.001 and r = 0.296, respectively). On linear regression model, fPSA was found as a stronger predictive for PV (AUC = 0.75, p < 0.001) when compared to age (AUC = 0.64, p < 0.001), and tPSA (AUC = 0.69, p = 0.013).
  
  
  CONCLUSIONS
  Although tPSA is an important prognostic factor for predicting PV, the predictive value of fPSA is higher. PV can easily be predicted by using age, and serum tPSA and fPSA levels.
authors.affiliation: a Department of Urology , Bursa Yuksek Ihtisas Training and Research Hospital , Bursa , Turkey .
authors.forename: Soner
authors.initials: S
authors.lastname: Coban
authors.affiliation: b Department of Urology , Ankara Training and Research Hospital , Ankara , Turkey .
authors.forename: Omer Gokhan
authors.initials: OG
authors.lastname: Doluoglu
authors.affiliation: c Department of Urology , Faculty of Medicine, University of Afyon Kocatepe , Afyon , Turkey , and.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Keles
authors.affiliation: d Department of Family Medicine , Bursa Yuksek Ihtisas Training and Research Hospital , Bursa , Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Demirci
authors.affiliation: a Department of Urology , Bursa Yuksek Ihtisas Training and Research Hospital , Bursa , Turkey .
authors.forename: Ali Riza
authors.initials: AR
authors.lastname: Turkoglu
authors.affiliation: a Department of Urology , Bursa Yuksek Ihtisas Training and Research Hospital , Bursa , Turkey .
authors.forename: Muhammet
authors.initials: M
authors.lastname: Guzelsoy
authors.affiliation: c Department of Urology , Faculty of Medicine, University of Afyon Kocatepe , Afyon , Turkey , and.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karalar
authors.affiliation: a Department of Urology , Bursa Yuksek Ihtisas Training and Research Hospital , Bursa , Turkey .
authors.forename: Murat
authors.initials: M
authors.lastname: Demirbas
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000097:blood / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000150:complications / Q000473:pathology
chemical_list: D017430:Prostate-Specific Antigen
keywords: Benign prostatic hyperplasia; estimation; free prostate-specific antigen; prostate volume; prostate-specific antigen