title: Synthesis of magnetofluorescence Gd-doped CuInS2/ZnS quantum dots with enhanced longitudinal relaxivity.
abstract: In this paper, we describe the rapid microwave-assisted synthesis of Gd(3+)-doped CuInS2 (Gd:CIS) quaternary quantum dots (q-dots), which integrate the functions of optical fluorescence and magnetic resonance imaging. Through passivation of ZnS shells around Gd:CIS cores, high-quality and robust photostable Gd:CIS/ZnS core/shell q-dots with enhanced quantum yields were obtained. The intensity and peak-to-peak linewidth of the electron spin resonance (EPR) signal were found to vary depending on the Gd(3+) concentration of Gd:CIS/ZnS. Benefiting from the incorporation of paramagnetic Gd(3+) ions, the formed q-dots exhibited well-resolved and strong signals of electron paramagnetic resonance and provided significant contrast enhancement in T1-weighted images owing to the remarkably high longitudinal relaxivity (r1 = 55.90 mM(-1) s(-1)) and low r2/r1 ratio (1.42), which are significantly higher than those of commercially available T1 contrast agents. We expect that this facile one-pot synthetic strategy can be extended to the preparation of other Cu-based sulfide quaternary nanomaterials.
authors.affiliation: Department of Chemical Engineering, National Taiwan University of Science and Technology, 43, Section 4, Keelung Road, Taipei, 10607, Taiwan, Republic of China. jychang@mail.ntust.edu.tw.
authors.forename: Jia-Yaw
authors.initials: JY
authors.lastname: Chang
authors.affiliation: Department of Chemical Engineering, National Taiwan University of Science and Technology, 43, Section 4, Keelung Road, Taipei, 10607, Taiwan, Republic of China. jychang@mail.ntust.edu.tw.
authors.forename: Guan-Rong
authors.initials: GR
authors.lastname: Chen
authors.affiliation: Department of Chemical Engineering, National Taiwan University of Science and Technology, 43, Section 4, Keelung Road, Taipei, 10607, Taiwan, Republic of China. jychang@mail.ntust.edu.tw.
authors.forename: Jyun-Dong
authors.initials: JD
authors.lastname: Li