title: Interaction of EGFR to δ-catenin leads to δ-catenin phosphorylation and enhances EGFR signaling.
abstract: Expression of δ-catenin reportedly increases during late stage prostate cancer. Furthermore, it has been demonstrated that expression of EGFR is enhanced in hormone refractory prostate cancer. In this study, we investigated the possible correlation between EGFR and δ-catenin in prostate cancer cells. We found that EGFR interacted with δ-catenin and the interaction decreased in the presence of EGF. We also demonstrated that, on one hand, EGFR phosphorylated δ-catenin in a Src independent manner in the presence of EGF and on the other hand, δ-catenin enhanced protein stability of EGFR and strengthened the EGFR/Erk1/2 signaling pathway. Our findings added a new perspective to the interaction of EGFR to the E-cadherin complex. They also provided novel insights to the roles of δ-catenin in prostate cancer cells.
authors.affiliation: College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju 500-757, Korea.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: He
authors.affiliation: College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju 500-757, Korea.
authors.forename: Taeyong
authors.initials: T
authors.lastname: Ryu
authors.affiliation: College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju 500-757, Korea.
authors.forename: Nensi
authors.initials: N
authors.lastname: Shrestha
authors.affiliation: College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju 500-757, Korea.
authors.forename: Tingting
authors.initials: T
authors.lastname: Yuan
authors.affiliation: College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Sunchon 540-742, Korea.
authors.forename: Hangun
authors.initials: H
authors.lastname: Kim
authors.affiliation: College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju 500-757, Korea.
authors.forename: Hridaya
authors.initials: H
authors.lastname: Shrestha
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Young-Chang
authors.initials: YC
authors.lastname: Cho
authors.affiliation: Korea Basic Science Institute, Gwangju Center, Gwangju 500-757, Korea.
authors.forename: Young-Woo
authors.initials: YW
authors.lastname: Seo
authors.affiliation: Department of Life Science, Bio Imaging and Cell Dynamics Research Center, Gwangju Institute of Science and Technology, Gwangju, Korea.
authors.forename: Woo Keun
authors.initials: WK
authors.lastname: Song
authors.affiliation: College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju 500-757, Korea.
authors.forename: Kwonseop
authors.initials: K
authors.lastname: Kim
mesh_terms: D000818:Animals; D015820:Cadherins / Q000378:metabolism; D051177:Catenins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004705:Endocytosis; D004815:Epidermal Growth Factor / Q000494:pharmacology; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D020935:MAP Kinase Signaling System; D010766:Phosphorylation / Q000187:drug effects; D011485:Protein Binding; D055550:Protein Stability; D021381:Protein Transport; D015398:Signal Transduction; D019061:src-Family Kinases / Q000378:metabolism; D000095002:Delta Catenin
chemical_list: D015820:Cadherins; D051177:Catenins; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D019061:src-Family Kinases; D000095002:Delta Catenin