title: A Concept for the analysis of repeatability and precision of corneal shape measurements.
abstract: We propose a framework for the analysis of the repeatability and precision of corneal elevation and the repeatability of corneal thickness data measured by clinically used topographers and tomographers. The repeatability is given by the standard deviation of different measurements of the same eye for each data point. The differences between measurements can partially be explained by different positions of the eye at each measurement. The precision is given by the standard deviation of the data after correction for displacements (decentration, tilts, rotations). The applicability is demonstrated using measurements of the Pentacam HR [1] (Oculus Optikgeräte GmbH, Wetzlar, Germany) Scheimpflug tomographer. It provides anterior corneal elevation data with a precision that was almost limited by the axial resolution of 1μm in the central 6mm zone. This is approximately five times better than the precision of the posterior elevation. The results can be applied to surface approximation of the exported corneal elevation data and give a measure for the goodness of the fit.
authors.affiliation: Experimental Ophthalmology, Saarland University, Kirrberger Str. 100, Bldg. 22, 66421 Homburg, Germany. Electronic address: Simon.Schroeder@uks.eu.
authors.forename: Simon
authors.initials: S
authors.lastname: Schröder
authors.affiliation: Experimental Ophthalmology, Saarland University, Kirrberger Str. 100, Bldg. 22, 66421 Homburg, Germany.
authors.forename: Timo
authors.initials: T
authors.lastname: Eppig
authors.affiliation: Experimental Ophthalmology, Saarland University, Kirrberger Str. 100, Bldg. 22, 66421 Homburg, Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Langenbucher
mesh_terms: D000328:Adult; D000465:Algorithms; D003198:Computer Simulation; D003315:Cornea / Q000033:anatomy & histology*; D063171:Corneal Pachymetry / Q000379:methods*; D019781:Corneal Topography / Q000379:methods*; D003627:Data Interpretation, Statistical; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D015233:Models, Statistical; D015588:Observer Variation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Corneal topography; Hornhaut-Topographie; Pachymetrie; Pentacam HR; Präzision; Wiederholbarkeit; pachymetry; precision; repeatability