title: Cystic Adverse Local Tissue Reactions in Asymptomatic Modular Metal-on-Metal Total Hips May Decrease Over Time.
abstract: The presence of pain as a harbinger of bearing-related problems has recently been challenged. Adverse local tissue reactions (ALTRs) have been noted on cross-sectional imaging even in asymptomatic patients. The purpose of this study was to determine the natural history of such lesions in asymptomatic patients.
  
  
  
  Eighty-three asymptomatic patients with modular metal-on-metal total hip arthroplasties underwent metal ion reports and metal artifact reduction sequence magnetic resonance imaging (MARS MRI). MARS MRI images were reviewed and evaluated for the presence or absence of an ALTR lesion by a musculoskeletal radiologist and the senior author. We defined an ALTR lesion as abnormal fluid collections, solid or semisolid pseudotumors, or muscle or bone damage and was classified according to the MRI Classification System of Hart et al. In addition, serum cobalt and chromium levels were measured and analyzed at the time of MRI.
  
  
  
  Twenty-six of 83 (31%) asymptomatic patients had cystic lesions identified. All patients with positive MRIs were contacted to have repeat studies a year later. Nineteen of 26 were available for follow-up. Three patients who became symptomatic were revised. Most ALTRs in asymptomatic patients with modular metal-on-metal total hip arthroplasties that underwent repeat MARS MRI decreased in size (15 of 19 [79%]); 3 lesions increased, whereas 1 remained the same. All patients in the series had Co and Cr ion levels below the threshold of 7 ppb.
  
  
  
  Although most cystic lesions decreased in size, vigilance is still required as 3 patients became symptomatic requiring revision.
authors.affiliation: Illinois Bone & Joint Institute-Morton Grove, Morton Grove, Illinois.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Goldstein
authors.affiliation: OrthoCarolina Hip & Knee Center, Charlotte, North Carolina.
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Fehring
authors.affiliation: OrthoCarolina Hip & Knee Center, Charlotte, North Carolina.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Fehring
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D016477:Artifacts; D002857:Chromium / Q000097:blood; D003035:Cobalt / Q000097:blood; D005260:Female; D006615:Hip / Q000601:surgery*; D006621:Hip Joint / Q000601:surgery*; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D061825:Metal-on-Metal Joint Prostheses / Q000009:adverse effects*; D008875:Middle Aged; D011475:Prosthesis Failure; D012086:Reoperation / Q000706:statistics & numerical data
chemical_list: D002857:Chromium; D003035:Cobalt
keywords: adverse local tissue reactions; cross-sectional imaging; magnetic resonance imaging; metal-on-metal; natural history of disease; total hip arthroplasty