title: The Association Between Circulating Levels of miRNA-181a and Pancreatic Beta Cells Dysfunction via SMAD7 in Type 1 Diabetic Children and Adolescents.
abstract: BACKGROUND
  miRNA-181a has been implicated in autoimmunity and apoptosis. Therefore, this study was conducted to explore its possible role in pancreatic beta-cells dysfunction.
  
  
  METHODS
  miRNA-181a expression was evaluated by real-time PCR in serum of 40 type 1 diabetic children and adolescents and 40 age- and gender-matched healthy controls.
  
  
  RESULTS
  miRNA-181a expression was significantly higher in diabetic children and adolescents and it was negatively correlated to fasting C-peptide and SMAD7 levels.
  
  
  CONCLUSIONS
  miRNA-181a appears to play a potential role in pancreatic beta-cells dysfunction via SMAD7.
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Ain Shams University, Cairo, Egypt. enassamer@hotmail.com.
authors.forename: Enas Samir
authors.initials: ES
authors.lastname: Nabih
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Nevine Gamal
authors.initials: NG
authors.lastname: Andrawes
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000235:genetics*; D005260:Female; D006801:Humans; D050417:Insulin-Secreting Cells / Q000473:pathology*; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D051906:Smad7 Protein / Q000378:metabolism*; D055986:Vital Signs
chemical_list: C000608460:MIRN-181 microRNA, human; D035683:MicroRNAs; C497806:SMAD7 protein, human; D051906:Smad7 Protein
keywords: C-peptide; SMAD7; T1DM; miRNA; miRNA-181a