title: High-flow nasal cannula oxygen therapy for acute exacerbation of interstitial pneumonia: A case series.
abstract: We report 3 cases (all men, age: 69-81 years) of acute exacerbation of interstitial pneumonia (AEIP) that were successfully treated with a high-flow nasal cannula (HFNC), which delivers heated, humidified gas at a fraction of inspired oxygen (FIO2) up to 1.0 (100%). Oxygenation was insufficient under non-rebreathing face masks; however, the introduction of HFNC with an FIO2 of 0.7-1.0 (flow rate: 40 L/min) improved oxygenation and was well-tolerated until the partial pressure of oxygen in blood/FIO2 ratio increased (between 21 and 26 days). Thus, HFNC might be an effective and well-tolerated therapeutic addition to the management of AEIP.
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: h_5amm1218@yahoo.co.jp.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Horio
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: ttakihara@gmail.com.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Takihara
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: niimi_k1002@yahoo.co.jp.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Niimi
authors.affiliation: Division of General Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: im_little_pea@hotmail.com.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Komatsu
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: satomasa@tokai-u.jp.
authors.forename: Masako
authors.initials: M
authors.lastname: Sato
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: jntnk723@gmail.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Tanaka
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: takihiroto@gmail.com.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Takiguchi
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: hiromiogur@gmail.com.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Tomomatsu
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: k.tomomatu@gmail.com.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Tomomatsu
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: hayama@is.icc.u-tokai.ac.jp.
authors.forename: Naoki
authors.initials: N
authors.lastname: Hayama
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: tyoguma@db4.so-net.ne.jp.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Oguma
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: aokitaku@is.icc.u-tokai.ac.jp.
authors.forename: Takuya
authors.initials: T
authors.lastname: Aoki
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: urantets@is.icc.u-tokai.ac.jp.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Urano
authors.affiliation: Division of General Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: takagia@is.icc.u-tokai.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takagi
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: ko-asano@tokai-u.jp.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Asano
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000072601:Cannula; D018450:Disease Progression; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000628:therapy*; D008297:Male; D010102:Oxygen Inhalation Therapy / Q000295:instrumentation* / Q000379:methods*; D016896:Treatment Outcome
keywords: Acute exacerbation; Acute respiratory failure; High-flow nasal cannula; Interstitial pneumonia; Oxygen therapy