title: Gliosarcoma with leiomyomatous differentiation: A case report with an emphasis on histogenesis.
abstract: Gliosarcoma is an uncommon high-grade tumor which constitutes about 2% of all glioblastomas. These tumors have the histological hallmark of a biphasic pattern of high-grade glial and sarcomatous components. The histogenesis of these tumors is controversial. We report a case of primary gliosarcoma in an adult male with leiomyomatous differentiation and discuss the histogenesis as it appears in our case. Primary gliosarcomas of the brain are clinically challenging with a poor clinical outcome.
authors.affiliation: Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Saumya
authors.initials: S
authors.lastname: Shukla
authors.forename: Namrata Punit
authors.initials: NP
authors.lastname: Awasthi
authors.forename: Pradyumn
authors.initials: P
authors.lastname: Singh
authors.forename: Nuzhat
authors.initials: N
authors.lastname: Husain
authors.forename: Bal Krishna
authors.initials: BK
authors.lastname: Ojha
mesh_terms: D000328:Adult; D002454:Cell Differentiation; D018316:Gliosarcoma / Q000150:complications / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged