title: Association study of BUD13-ZNF259 gene rs964184 polymorphism and hemorrhagic stroke risk.
abstract: We aimed to evaluate the association of rs964184 of BUD13-ZNF259 gene with the risk of hemorrhagic stroke (HS). A total of 138 HS cases and 587 controls were recruited for the association of rs964184 of BUD13-ZNF259 gene with the risk of HS. Tm shift PCR was used for genotyping. We were unable to find the association of rs964184 of BUD13-ZNF259 gene with the risk of HS (P>0.05). Significant difference was found in the TG level among the three genotypes (CC: 1.51±1.02; CG: 1.68±1.10; GG: 1.90±1.11, P=0.036). The TG level showed strong correlation with rs964184 genotypes (P=0.010, correlation=0.101). Significantly higher TC, HDL-C, and LDL-C levels were observed in the case group. And no difference was found in the TG, ApoA-I, ApoB. Our case-control study supported the significant association between rs964184 genotype and the blood TG concentration, although we were unable to find association between BUD13-ZNF259 rs964184 and the risk of HS in Han Chinese.
authors.affiliation: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University Ningbo 315010, Zhejiang, China.
authors.forename: Shengjun
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University Ningbo 315010, Zhejiang, China.
authors.forename: Jikuang
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University Ningbo 315010, Zhejiang, China.
authors.forename: Zhepei
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University Ningbo 315010, Zhejiang, China.
authors.forename: Keqin
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University Ningbo 315010, Zhejiang, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Nie
authors.affiliation: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University Ningbo 315010, Zhejiang, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University Ningbo 315010, Zhejiang, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University Ningbo 315010, Zhejiang, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University Ningbo 315010, Zhejiang, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
keywords: BUD13-ZNF259; Hemorrhagic stroke; SNP; TG; rs964184