title: Osteogenesis effect of guided bone regeneration combined with alveolar cleft grafting: assessment by cone beam computed tomography.
abstract: Cone beam computed tomography (CBCT) allows for a significantly lower radiation dose than conventional computed tomography (CT) scans and provides accurate images of the alveolar cleft area. The osteogenic effect of guided bone regeneration (GBR) vs. conventional alveolar bone grafting alone for alveolar cleft defects was evaluated in this study. Sixty alveolar cleft patients were divided randomly into two groups. One group underwent GBR using acellular dermal matrix film combined with alveolar bone grafting using iliac crest bone grafts (GBR group), while the other group underwent alveolar bone grafting only (non-GBR group). CBCT images were obtained at 1 week and at 3 months following the procedure. Using Simplant 11.04 software, the bone resorption rate was calculated and compared between the two groups. The bone resorption rate from 1 week to 3 months following bone grafting without the GBR technique was 36.50±5.04%, whereas the bone resorption rate using the GBR technique was 31.69±5.50% (P=0.017). The application of autogenous iliac bone combined with the GBR technique for alveolar bone grafting of alveolar cleft patients can reduce bone resorption and result in better osteogenesis.
authors.affiliation: Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, China; The Key Laboratory of Oral Clinical Medicine of Shandong Province, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: wenlinxiao@sina.com.
authors.forename: W-L
authors.initials: WL
authors.lastname: Xiao
authors.affiliation: Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, China; The Key Laboratory of Oral Clinical Medicine of Shandong Province, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: D-Z
authors.initials: DZ
authors.lastname: Zhang
authors.affiliation: Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, China; The Key Laboratory of Oral Clinical Medicine of Shandong Province, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: X-J
authors.initials: XJ
authors.lastname: Chen
authors.affiliation: Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, China; The Key Laboratory of Oral Clinical Medicine of Shandong Province, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: C
authors.initials: C
authors.lastname: Yuan
authors.affiliation: Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, China; The Key Laboratory of Oral Clinical Medicine of Shandong Province, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: L-F
authors.initials: LF
authors.lastname: Xue
mesh_terms: D064728:Alveolar Bone Grafting; D000539:Alveolar Process / Q000002:abnormalities / Q000000981:diagnostic imaging*; D001861:Bone Regeneration; D002972:Cleft Palate / Q000000981:diagnostic imaging / Q000601:surgery*; D054893:Cone-Beam Computed Tomography; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D010012:Osteogenesis; D011446:Prospective Studies
keywords: CBCT; alveolar bone grafting; bone resorption rate; guided bone regeneration