title: Combinational enhancing effects of formulation and encapsulation on digestive stability and intestinal transport of green tea catechins.
abstract: The hypothesis was that green tea catechins (GTCs) formulated with vitamin C and xylitol followed by enteric coating with hydroxypropyl methyl cellulose phthalate (HPMCP) or encapsulated into γ-cyclodextrin (γ-CD) could enhance intestinal absorption of GTCs. Surface morphology and size obtained by SEM were different. Digestive stability of GTCs encapsulated into γ-CD or coated with HPMCP was enhanced up to 65.56% or 57.63%, respectively. When GTCs were formulated, the digestive stability was greater than the one not formulated. Formulated GTCs followed by encapsulation into γ-CD significantly increased intestinal transport. Absorption of GTCs was 2.8%, 9.64%, 11.97%, 8.41% and 14.36% for only GTCs, GTCs encapsulated into γ-CD, formulated GTCs encapsulated into γ-CD, GTCs coated with HPMCP and formulated GTCs coated with HPMCP, respectively. This study suggests that GTCs, formulated with vitamin C and xylitol followed by γ-CD encapsulation or HPMCP enteric coating, provide combinational effect to increase bioavailability of GTCs.
authors.affiliation: a Department of Food Science & Technology , Sejong University , Seoul , Republic of Korea.
authors.forename: Yu-Ra
authors.initials: YR
authors.lastname: Son
authors.affiliation: a Department of Food Science & Technology , Sejong University , Seoul , Republic of Korea.
authors.forename: Jae-Hwan
authors.initials: JH
authors.lastname: Chung
authors.affiliation: a Department of Food Science & Technology , Sejong University , Seoul , Republic of Korea.
authors.forename: Sanghoon
authors.initials: S
authors.lastname: Ko
authors.affiliation: a Department of Food Science & Technology , Sejong University , Seoul , Republic of Korea.
authors.forename: Soon-Mi
authors.initials: SM
authors.lastname: Shim
mesh_terms: D018938:Caco-2 Cells; D002392:Catechin / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D004063:Digestion; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D007408:Intestinal Absorption; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D013608:Tablets, Enteric-Coated; D013662:Tea / Q000737:chemistry; D047408:gamma-Cyclodextrins / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D013608:Tablets, Enteric-Coated; D013662:Tea; D047408:gamma-Cyclodextrins; D002392:Catechin; D008747:Methylcellulose; C053309:hydroxypropyl methylcellulose phthalate
keywords: Green tea catechins; HPMCP enteric coating; absorption; digestive stability; formulation; intestinal absorption; γ-CD encapsulation