title: Association between Bethesda Categories and Ultrasound Features of Conventional Papillary Thyroid Carcinoma.
abstract: The association between categories 3, 5 and 6 of the Bethesda System for Reporting Thyroid Cytopathology and the clinical and ultrasonography (US) features of conventional papillary thyroid carcinoma (PTC) was evaluated. We included 2005 patients diagnosed with conventional PTC at surgery and Bethesda categories 3, 5 and 6 at pre-operative US-guided fine-needle aspiration. Multinomial regression analysis was performed to determine the odds ratio (ORs) of each US feature associated with category 3 or 5, with category 6 as reference. Category 3 and 5 PTCs were smaller (ORs = 0.925 and 0.937) and did not exhibit marked hypo-echogenicity (ORs = 0.341 and 0.268) compared with category 6 PTCs. Category 3 and 5 PTCs exhibited significant macrocalcification (ORs = 2.372 and 1.594) and heterogeneous parenchyma (OR = 1.265 in category 5). In conclusion, conventional PTCs pre-operatively aspirated as Bethesda category 3, 5 or 6 significantly differ in size, macrocalcification, underlying thyroid parenchymal echogenicity and final assessment of US features.
authors.affiliation: Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Ga Ram
authors.initials: GR
authors.lastname: Kim
authors.affiliation: Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Kim
authors.affiliation: Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Kwak
authors.affiliation: Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Electronic address: artemis4u@yuhs.ac.
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Moon
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology*; D002291:Carcinoma, Papillary; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D060787:Neoplasm Grading; D015995:Prevalence; D015203:Reproducibility of Results; D056910:Republic of Korea / Q000453:epidemiology; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology*; D014463:Ultrasonography / Q000379:methods*
keywords: Bethesda category; Conventional subtype; Fine-needle aspiration; Papillary thyroid carcinoma; Ultrasonography