title: Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis.
abstract: Hidradenocarcinoma (HAC) is a rare adenexal tumor with a propensity for the head and neck region and extremities. We report a case of hidradenocarcinnoma in a 56-year-old woman with a mass on her right palm sampled by fine-needle aspiration and later confirmed on histological examination. Fine-needle aspiration cytology revealed a dual population of cells including polyhedral eosinophilic cells and glycogen containing cells with pale/clear cytoplasm. The nuclei were pleomorphic with prominent nucleoli. Occassional papillary structures were identified on the cell block material. A series of immunohistochemical stains were performed and an adnexal neoplasm was suggested. The mass was resected. On histologic sections, infiltration into the adjacent soft tissue was identified. After an additional series of immunohistochemical stains, the diagnosis was confirmed as a HAC. Herein, we present our findings and discuss the differential diagnoses.
authors.affiliation: Department of Orthopaedic Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors.forename: Alexander H
authors.initials: AH
authors.lastname: Jinnah
authors.affiliation: Department of Orthopaedic Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Emory
authors.affiliation: Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: Mai
authors.affiliation: Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors.forename: Simon
authors.initials: S
authors.lastname: Bergman
authors.affiliation: Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors.forename: Ziyan T
authors.initials: ZT
authors.lastname: Salih
mesh_terms: D018250:Acrospiroma / Q000473:pathology*; D044963:Biopsy, Fine-Needle; D002277:Carcinoma / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000473:pathology*
keywords: cutaneous adnexal tumors; cytology; eccrine neoplasms; fine-needle aspiration; hidradenocarcinoma