title: The BRAF V600E mutation predicts poor survival outcome in patients with papillary thyroid carcinoma: a meta analysis.
abstract: BACKGROUND
  There have been contradictory data on whether or not BRAF V600E mutation should be regard as a poor prognosis predictor of papillary thyroid carcinoma (PTC). To settle down the conflict, this metaanalysis is prepared to clarify the present prognostic role of BRAF V600E mutation in patients with PTC.
  
  
  METHODS
  The relevant published researches were incorporated according to the defined inclusion/exclusion criteria from PubMed. The effect sizes of outcome parameters were estimated by hazard ratios (HRs).
  
  
  RESULTS
  The current meta-analysis included 19 researches with a total of 6087 patients. We have found that patients with BRAF V600E mutation have a poor overall survival (the pooled HR=2.91, 95% confidence interval (CI): 1.35-6.29). Furthermore, subgroup analysis of the recurrence-free survival (RFS) of PTC patients by races indicated that BRAF V600E mutation predicts poor RFS of patients (the pooled HR=1.63, 95% CI: 1.37-1.93), both Caucasian (the pooled HR=1.57, 95% CI: 1.30-1.90) and Asian (the pooled HR=1.91, 95% CI: 1.28-2.87).
  
  
  CONCLUSIONS
  The poor prognosis predicted role of BRAF V600E mutation in PTC was certified from the current meta-analysis. The BRAF V600E mutation may be used as a prognostic predictor of patients with PTC.
authors.affiliation: Department of The Thyroid Surgery 2, The First Affiliated Hospital of Zhengzhou University Jianshedong Road, No. 1, Zhengzhou 450052, Henan, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of The Thyroid Surgery 2, The First Affiliated Hospital of Zhengzhou University Jianshedong Road, No. 1, Zhengzhou 450052, Henan, China.
authors.forename: Shuijun
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of The Thyroid Surgery 2, The First Affiliated Hospital of Zhengzhou University Jianshedong Road, No. 1, Zhengzhou 450052, Henan, China.
authors.forename: Shouhua
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Department of The Thyroid Surgery 2, The First Affiliated Hospital of Zhengzhou University Jianshedong Road, No. 1, Zhengzhou 450052, Henan, China.
authors.forename: Danhua
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of The Thyroid Surgery 2, The First Affiliated Hospital of Zhengzhou University Jianshedong Road, No. 1, Zhengzhou 450052, Henan, China.
authors.forename: Xinguang
authors.initials: X
authors.lastname: Qiu
keywords: BRAF V600E mutation; Thyroid; meta-analysis; thyroid papillary carcinoma (PTC)