title: Invasive Aspergillosis: Current Strategies for Diagnosis and Management.
abstract: Aspergillosis remains a significant cause of morbidity and mortality in the immunocompromised population. The spectrum of disease is broad, ranging from severe and rapidly fatal infection to noninvasive disease. The diversity of patients and risk factors complicates diagnostic and therapeutic decision-making. Invasive procedures are often precluded by host status; noninvasive diagnostic tests vary in their sensitivity and specificity. Advancements in understanding the pathophysiology of invasive aspergillosis and host genetics in differential risk have also occurred. Future work may assist in therapeutic decision-making and patient prognosis. Voriconazole remains the preferred agent for treatment. Additional alternatives have emerged.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center and South Texas Veterans Health Care System, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
authors.forename: Jose
authors.initials: J
authors.lastname: Cadena
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, University of California - Davis, 1 Shields Avenue, Tupper Hall, Room 3146, Davis, CA, USA.
authors.forename: George R
authors.initials: GR
authors.lastname: Thompson
authors.affiliation: Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center and South Texas Veterans Health Care System, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. Electronic address: patterson@uthscsa.edu.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Patterson
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D006801:Humans; D016867:Immunocompromised Host; D012307:Risk Factors
chemical_list: D000935:Antifungal Agents
keywords: Aspergilloma; Aspergillosis; Chronic cavitary aspergillosis; Invasive pulmonary aspergillosis; Resistance