title: [Acquired Pelger-Huët anomaly/abnormal chromatin clumping of granulocytes after allogeneic hematopoietic stem cell transplantation for acute myeloid leukaemia: medication or relapse? ].
abstract: An acute myeloid leukemia was diagnosed in a 53-year-old female patient. She received an allogeneic stem cell transplant. After this transplant, some neutrophils with hyposegmented nucleus and abnormal chromatin clumping appeared in the peripheral blood, and their number gradually increased. The hypothesis of early relapse after transplant was ruled out and drug-related anomaly was suspected. The authors discuss about morphological features of constitutional and acquired Pelger-Huët anomaly. In the patient reported here, ciclosporine seemed to be involved in the phenomenon, as the morphological anomaly of the neutrophils gradually decreased after the drug was discontinued.
authors.affiliation: Laboratoire d'hématologie, Institut de biologie en santé, CHU Angers, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Daufresne
authors.affiliation: Laboratoire d'hématologie, Institut de biologie en santé, CHU Angers, France.
authors.forename: Laurane
authors.initials: L
authors.lastname: Cottin
authors.affiliation: Laboratoire d'hématologie, Institut de biologie en santé, CHU Angers, France.
authors.forename: Jean-Maxime
authors.initials: JM
authors.lastname: Girard
authors.affiliation: Laboratoire d'hématologie, Institut de biologie en santé, CHU Angers, France.
authors.forename: Iris
authors.initials: I
authors.lastname: Henriot
authors.affiliation: Laboratoire d'hématologie, Institut de biologie en santé, CHU Angers, France.
authors.forename: Anna
authors.initials: A
authors.lastname: Zharkova
authors.affiliation: Service des maladies du sang, CHU Angers, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Sutra Del Galy
authors.affiliation: Service des maladies du sang, CHU Angers, France.
authors.forename: Aline
authors.initials: A
authors.lastname: Schmidt
authors.affiliation: Laboratoire d'hématologie, Institut de biologie en santé, CHU Angers, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Ribourtout
authors.affiliation: Laboratoire d'hématologie, Institut de biologie en santé, CHU Angers, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Zandecki
mesh_terms: D002843:Chromatin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D016572:Cyclosporine / Q000009:adverse effects*; D003937:Diagnosis, Differential; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis*; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000628:therapy*; D008875:Middle Aged; D010381:Pelger-Huet Anomaly / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*; D012008:Recurrence; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods; D014184:Transplantation, Homologous / Q000009:adverse effects
chemical_list: D002843:Chromatin; D016572:Cyclosporine
keywords: Pelger-Huët anomaly; TP53; abnormal chromatin clumping; drug; dysgranulopoiesis; granulocyte; neutrophil; polymorphonuclear neutrophil