title: Post-Transcriptional Mechanisms Regulating Epidermal Stem and Progenitor Cell Self-Renewal and Differentiation.
abstract: Epidermal stem and progenitor cells exist within the basal layer of the epidermis and serve to replenish the loss of differentiated cells because of normal turnover or injury. Current efforts have focused on elucidating the transcriptional regulation of epidermal stem cell self-renewal and differentiation. However, recent studies have pointed to an emerging and prominent role for post-transcriptional regulation of epidermal cell fate decisions. In this review, we will focus on post-transcriptional mechanisms including noncoding RNAs, RNA binding proteins, and mRNA decay-mediated control of epidermal stem and progenitor cell function in the skin.
authors.affiliation: Department of Dermatology, University of California, San Diego, La Jolla, California, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA; UCSD Stem Cell Program, University of California, San Diego, La Jolla, California, USA.
authors.forename: Jingting
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Dermatology, University of California, San Diego, La Jolla, California, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA; UCSD Stem Cell Program, University of California, San Diego, La Jolla, California, USA. Electronic address: gsen@ucsd.edu.
authors.forename: George L
authors.initials: GL
authors.lastname: Sen
mesh_terms: D020413:3' Untranslated Regions; D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D000066673:Cell Self Renewal; D053487:DEAD-box RNA Helicases / Q000378:metabolism; D000078404:Epidermal Cells; D055354:Exosomes / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics; D009154:Mutation; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D062085:RNA, Long Noncoding / Q000235:genetics; D013234:Stem Cells / Q000166:cytology*
chemical_list: D020413:3' Untranslated Regions; D035683:MicroRNAs; D011518:Proto-Oncogene Proteins; D062085:RNA, Long Noncoding; C094683:DDX6 protein, human; D053487:DEAD-box RNA Helicases