title: CLINICAL SIGNIFICANCE LEVELS OF C-REACTIVE PROTEIN AND CERULOPLASMIN IN PATIENTS WITH ISCHEMIC HEART DISEASE.
abstract: BACKGROUND
  The study examined the relationship of levels of ceruloplasmin and CRP in patients with coronary heart disease and assessed the possibility of their use for diagnosis and prediction of developing complications.
  
  
  OBJECTIVE
  The study investigated the relationship of levels of ceruloplasmin and CRP in patients with coronary heart disease and their potential use in the diagnosis and prediction of complications.
  
  
  METHODS
  Examined 117 patients with ischemic heart disease at the age of 39 to 80 years (median age + 13.9 61.7 years), among them 56 were women and 61 men. Assessment of prognosis in patients with ischemic heart disease was conducted based on the two-year observation.
  
  
  RESULTS
  The reverse relationship between the levels of ceruloplasmin and CRP was identified. When comparing the survival curves without adverse events using the log-rank analysis in patients with levels of CPU of more than 0.2 grams per liter and CRP of less than 6.0 mg/l, the prognosis was significantly better than in patients with simultaneously detected low levels of the CPU (less than 0.2 g/l) and high levels of CRP (more than 6.0 mg/l) in the blood (p < 0.05), CONCLUSIONS: Highly sensitive measurement method of levels of c-reactive protein in patients with coronary heart disease combined with measurement of levels of ceruloplasmin, gives an opportunity to assess the activity of vascular inflammation that can be used to predict the development of acute coronary events.
authors.forename: L V
authors.initials: LV
authors.lastname: Daybanyrova
authors.forename: O P
authors.initials: OP
authors.lastname: Shevchenko
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D002570:Ceruloplasmin / Q000032:analysis*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D002570:Ceruloplasmin