title: Association between radiation dose to the heart and myocardial fatty acid metabolic impairment due to chemoradiation-therapy: Prospective study using I-123 BMIPP SPECT/CT.
abstract: To investigate long term changes in myocardial fatty acid metabolic impairment caused by chemoradiation-therapy (CRT).
  
  
  
  We investigated 12 esophageal cancer patients who underwent SPECT/CT using I-123-labeled fatty acid analog (BMIPP) at pre-CRT, pre-boost irradiation, 3-month post-CRT, and 1-year post-CRT. The myocardial uptake was measured using the defect score and the total percentage of uptake (%uptake), which were defined as the sum of the visual scores and that of %uptake in each of 17 segments in the left ventricle (LV), respectively. The correlations between radiation dose to the heart (mean dose, V20, V40, and V60 of the LV and the whole heart (WH)) and the change of myocardial BMIPP uptake from pre-CRT (Δmyocardial BMIPP uptake) were assessed.
  
  
  
  At pre-boost, Δmyocardial BMIPP uptake was significantly correlated with LV-V40 and WH-V60. At 3-month post-CRT, Δmyocardial BMIPP uptake was significantly correlated with LV-V40, WH-V40, and WH-V60. However, there were no statistically significant correlations at 1-year post-CRT. Neither mean dose nor V20 of the LV/WH was significantly correlated with Δmyocardial BMIPP uptake at any time.
  
  
  
  In the long term after CRT, myocardial metabolism might be affected by factors other than the radiation dose to the heart.
authors.affiliation: Department of Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: takanami@rad.med.tohoku.ac.jp.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takanami
authors.affiliation: Department of Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Arai
authors.affiliation: Department of Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Rei
authors.initials: R
authors.lastname: Umezawa
authors.affiliation: Division of Radiology, Tohoku University Hospital, Sendai, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Takeuchi
authors.affiliation: Department of Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kadoya
authors.affiliation: Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Taki
authors.affiliation: Department of Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Jingu
authors.affiliation: Department of Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Takase
mesh_terms: D000368:Aged; D059248:Chemoradiotherapy / Q000009:adverse effects*; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D011446:Prospective Studies; D000072098:Single Photon Emission Computed Tomography Computed Tomography
chemical_list: D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C049338:iodofiltic acid
keywords: Esophageal cancer; Fatty acid metabolism; I-123 BMIPP; Radiation-induced heart disease; Radiotherapy