title: Assessment of clinicopathologic features in patients with pituitary adenomas in Northeast of Iran: A 13-year retrospective study.
abstract: BACKGROUND
  Intracranial lesions of the pituitary gland are common pituitary adenomas, accounting for 6-10% of all symptomatic intracranial tumors. In this retrospective study, the clinicopathologic features and survival rate of pituitary adenomas were evaluated.
  
  
  METHODS
  The present retrospective study was conducted on 83 patients with pituitary adenomas, referring to radiation oncology departments of Ghaem and Omid Hospitals, Mashhad, Iran, over a period of 13 years (1999-2012). Data obtained from clinical records including clinical features, type of surgery (if performed), treatment modality, overall survival rate, and progression-free survival rate were analyzed.
  
  
  RESULTS
  Eighty-three patients including 44 males (53%) and 39 females (47%) participated in this study. The median age was 40 years (age range: 10-69 years). Chiasm compression was reported in 62 patients (74.4%), and 45.78% of the subjects suffered from headaches. Functional and non-functional adenomas were reported in 44 (53.01%) and 39 (46.99%) patients, respectively. In cases with functional and non-functional adenomas, the disease was controlled in 95 and 84.5% of the subjects for 3 years, respectively. Furthermore, 1- and 3-year survival rates for functional adenoma were 84.6 and 23%, respectively; the corresponding values were 90.9 and 22.7% in non-functional adenomas, respectively.
  
  
  CONCLUSIONS
  In this study, a significant correlation between headache severity and type of adenoma was observed. So, application of surgery and radiotherapy together could be a highly effective approach for treating functional adenomas, although it is less efficient for the non-functional type.
authors.affiliation: Cancer Research Center AND Department of Radiation Oncology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Kazem
authors.initials: K
authors.lastname: Anvari
authors.affiliation: Department of Pathology, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mahmoud Reza
authors.initials: MR
authors.lastname: Kalantari
authors.affiliation: Department of Neurosurgery, School of Medicine, Shahid Kamiab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Fariborz
authors.initials: F
authors.lastname: Samini
authors.affiliation: Cancer Research Center AND Department of Radiation Oncology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Shahidsales
authors.affiliation: Cancer Research Center AND Department of Radiation Oncology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Seilanian-Toussi
authors.affiliation: Department of Radiation Oncology, School of Medicine, Omid Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Zakiyeh
authors.initials: Z
authors.lastname: Ghorbanpour
keywords: Functional Adenoma; Pituitary Adenoma; Survival Rate