title: Prepubertal Vulvar Fibroma: Neoplasm or Physiological Condition?
abstract: BACKGROUND
  Several authors have previously reconsidered vulvar fibroma, a rare prepubertal neoplasm, as a physiological labial asymmetry of early puberty, recommending a conservative approach for all cases, although some required further clarification.
  
  
  METHODS
  A fibrous mass found in the left labium majus of a 4-year-old girl was surgically removed. Imaging confirmed a relapse after 10 months and a second surgery was performed due to extremely rapid growth. No subsequent relapse occurred after 2 years of follow-up. Diagnosis confirmed prepubertal vulvar fibroma, with positive CD34 and lack of actin, desmin, S100, and estrogen receptors.
  
  
  CONCLUSIONS
  A diagnosis of prepubertal labial asymmetry should prompt careful consideration of several variables, such as age, and radiologic and histologic features, in order to differentiate between a physiological condition and a neoplasm.
authors.affiliation: Department of Obstetrics and Gynecology, Université Libre de Bruxelles, Erasme Hospital, Brussels, Belgium. Electronic address: oranite.goldrat@erasme.ulb.ac.be.
authors.forename: Oranite
authors.initials: O
authors.lastname: Goldrat
authors.affiliation: Department of Pediatric Surgery, Université Libre de Bruxelles, Erasme Hospital, Brussels, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lingier
authors.affiliation: Department of Radiology, Université Libre de Bruxelles, Erasme Hospital, Brussels, Belgium.
authors.forename: Anne
authors.initials: A
authors.lastname: Massez
authors.affiliation: Department of Pathology, Université Libre de Bruxelles, Erasme Hospital, Brussels, Belgium.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Noël
mesh_terms: D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000601:surgery
keywords: Hamartoma; Labial enlargement; Neoplasm; Physiological labium asymmetry; Prepubertal vulvar mass