title: Pericarditis with anaemia as a herald syndrome in a fatal presentation of cardiac lymphoma.
abstract: Primary cardiac lymphoma (PCL) is rare, accounting for 2% of all primary cardiac malignancies. Diagnosis is sometimes slow due to the non-specific nature of symptoms, causing a delay to treatment with potentially curative anthracycline chemotherapy. We report an unusual presentation of primary cardiac lymphoma in an immunocompetent man presenting with subacute isolated right-sided heart failure with pericarditis on a background of chronic anaemia and constitutional upset. Echocardiography demonstrated a pericardial mass invading the right atrium and compressing the tricuspid annulus. Diffuse large B-cell lymphoma was diagnosed after biopsy. This case highlights the importance of early imaging and hospitalisation in pericarditis with high-risk features such as high inflammatory markers, myocardial involvement (with troponin elevation), fever, immunosuppression or evidence of heart failure. The differential and diagnostic pathway of an intracardiac mass, and the treatment and prognosis of PCL, are discussed.
authors.affiliation: Department of Cardiology, King's College Hospital, London, UK.
authors.forename: Aish
authors.initials: A
authors.lastname: Sinha
authors.affiliation: Department of Cardiology, Wycombe General Hospital, High Wycombe, UK.
authors.forename: Timothy
authors.initials: T
authors.lastname: Davies
authors.affiliation: Department of Cardiology, Wycombe General Hospital, High Wycombe, UK.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Saif
authors.affiliation: Department of Cardiology, John Radcliffe Hospital, Headley Way, Oxford, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Apps
mesh_terms: D000368:Aged; D000740:Anemia / Q000150:complications*; D001706:Biopsy; D004452:Echocardiography; D017809:Fatal Outcome; D006325:Heart Atria / Q000473:pathology*; D006333:Heart Failure / Q000175:diagnosis* / Q000209:etiology; D006338:Heart Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D010493:Pericarditis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D010496:Pericardium / Q000473:pathology*; D011379:Prognosis; D012307:Risk Factors; D013577:Syndrome