title: Spatially divergent clonal evolution in multiple myeloma: overcoming resistance to BRAF inhibition.
authors.affiliation: Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany; German Cancer Research Center, Heidelberg, Germany;
authors.forename: Marc S
authors.identifier: 0000-0003-4181-6922
authors.initials: MS
authors.lastname: Raab
authors.affiliation: Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany; German Cancer Research Center, Heidelberg, Germany;
authors.forename: Nicola
authors.initials: N
authors.lastname: Lehners
authors.affiliation: Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany; German Cancer Research Center, Heidelberg, Germany;
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany;
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Ho
authors.affiliation: Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; and.
authors.forename: Peter
authors.initials: P
authors.lastname: Schirmacher
authors.affiliation: Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases, Heidelberg, Germany.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Goldschmidt
authors.affiliation: Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; and.
authors.forename: Mindaugas
authors.initials: M
authors.lastname: Andrulis
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D060965:Clonal Evolution / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D017354:Point Mutation; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors* / Q000235:genetics; D013449:Sulfonamides / Q000627:therapeutic use*; D000077484:Vemurafenib
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D047428:Protein Kinase Inhibitors; D013449:Sulfonamides; D000077484:Vemurafenib; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf