title: Conformational switch-mediated accelerated release of drug from cytosine-rich nucleic acid-capped magnetic nanovehicles.
abstract: A novel concept that the conformational switch of cytosine-rich DNA can accelerate the release of drug from DNA-capped nanovehicles is rationally devised. Our present strategy can greatly extend the potential usages of DNA molecules with specific sequences as conformational switch-controlled devices.
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of the Chinese Academy of Sciences, Beijing, 100039, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Fang
authors.initials: F
authors.lastname: Pu
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D003596:Cytosine / Q000737:chemistry*; D004337:Drug Carriers; D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D009696:Nucleic Acids; D004364:Pharmaceutical Preparations; D003596:Cytosine