title: Replication of Han Chinese GWAS loci for schizophrenia via meta-analysis of four independent samples.
abstract: Schizophrenia is a highly heritable psychiatric disorder with unclear aetiology. Recent genome-wide association studies (GWAS) in European populations have reported numerous susceptibility variants, while GWAS in East Asians also identified several risk loci but with fewer independent replications. Here we focus on nine single nucleotide polymorphisms (SNPs) which have shown genome-wide significant associations with schizophrenia in previous Han Chinese GWAS, and we tend to replicate the associations in four independent samples of East Asian origin including a total of 3977 cases and 5589 controls. The results showed that rs10489202 in MPC2 (BRP44) is significantly associated with schizophrenia in these East Asian replication samples (one-tailed P=5.75×10(-3), OR=1.12), and further meta-analysis after including previous GWAS data yielded a genome-wide significant association (two-tailed P=1.11×10(-10), OR=1.19), adding further support for the involvement of this locus in the genetic risk of schizophrenia, and future studies regarding the underlying molecular mechanisms of the risk association are necessary.
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: xiaoxiao.whu05@gmail.com.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, MD, United States.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D027321:Anion Transport Proteins / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D002681:China; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D033681:Mitochondrial Membrane Transport Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D027321:Anion Transport Proteins; C000595572:MPC2 protein, human; D033681:Mitochondrial Membrane Transport Proteins
keywords: East Asians; GWAS; MPC2; Replication; Schizophrenia; rs10489202