title: Clinical manifestations of IgA nephropathy combined with thin glomerular basement membrane nephropathy in children.
abstract: BACKGROUND
  Immunoglobulin A nephropathy (IgAN) and thin glomerular basement membrane nephropathy (TBMN) are the most common causes of persistent hematuria during childhood. The objective of this study is to determine the difference in clinical features and laboratory findings between pediatric patients with IgA deposited TBMN and IgAN alone.
  
  
  METHODS
  Between January 2000 and March 2009, 95 children were diagnosed with IgAN by renal biopsy. Clinical features and laboratory findings of patients with isolated IgAN and with IgAN plus TBMN were compared; the children diagnosed with IgAN were compared to 127 children who had been diagnosed with TBMN alone during the same period.
  
  
  RESULTS
  There were 71 (74.7%) of a total 95 patients that were diagnosed with isolated IgAN (Group1); in 24 (25.3%) of the 95 patients IgAN was combined with TBMN (Group 2). There was marked difference in the gender distribution between Group 2 and isolated TBMN patients. The degree of proteinuria and pathologic severity was higher in Group 1 compared with Group 2. Gross hematuria was present in both groups. There were no distinguishing features in the other laboratory parameters.
  
  
  CONCLUSIONS
  Patients with both IgAN and TBMN seem to have similar clinical features to patients with isolated IgAN; however, the latter tend to have better pathologic and laboratory findings, compared to the patients with IgAN alone.
authors.affiliation: Department of Pediatrics, Kyungpook National University, School of Medicine, Daegu, Korea.
authors.forename: Young
authors.initials: Y
authors.lastname: Ju Hwang
authors.affiliation: Department of Pediatrics, Kyungpook National University, School of Medicine, Daegu, Korea.
authors.forename: Dong
authors.initials: D
authors.lastname: Sub Kim
authors.affiliation: Department of Pediatrics, Kyungpook National University, School of Medicine, Daegu, Korea.
authors.forename: Cheol
authors.initials: C
authors.lastname: Woo Ko
authors.affiliation: Department of Pediatrics, Kyungpook National University, School of Medicine, Daegu, Korea.
authors.forename: Min
authors.initials: M
authors.lastname: Hyun Cho
authors.affiliation: Department of Pathology, Kyungpook National University, School of Medicine, Daegu, Korea.
authors.forename: Tae
authors.initials: T
authors.lastname: In Park
keywords: Children; Immunoglobulin A nephropathy; Thin glomerular basement membrane nephropathy