title: A Biological Tissue Adhesive and Dissolvent System for Intraocular Tumor Plaque Brachytherapy.
abstract: OBJECTIVE
  To examine a novel technique for simplified placement and removal of plaque brachytherapy by fibrin glue and urokinase (medac Gmbh, Hamburg, Germany).
  
  
  METHODS
  In six enucleated porcine eyes, plaques were placed on the episclera and fibrin glue was applied to cover it. Urokinase was used to dissolve the glue in three eyes and saline was used in three eyes. Adhesion strength was measured further on 15 plaques affixed to porcine eyes (glued in five with intact conjunctiva, glued in five with removed conjunctiva, and sutured in five).
  
  
  RESULTS
  Saline had no effect on the glue-plaque-eye complex, whereas the urokinase (0.38 mL ± 0.08 mL) easily dissolved the adhesion between the glue layer and surrounding tissues. The weight required to detach the plaques was 0.349 kg ± 0.173 kg for glued eyes with intact conjunctiva, 0.405 kg ± 0.083 kg for sutured eyes (P = .59), and 0.032 kg ± 0.004 kg for glued eyes without intact conjunctiva (P ≤ .015).
  
  
  CONCLUSIONS
  The usage of the biological adhesive and dissolvent system was applicable for plaque surgery in an ex vivo animal model.
authors.forename: Ofira
authors.initials: O
authors.lastname: Zloto
authors.forename: Vicktoria
authors.initials: V
authors.lastname: Vishnevskia-Dai
authors.forename: Joseph
authors.initials: J
authors.lastname: Moisseiev
authors.forename: Michael
authors.initials: M
authors.lastname: Belkin
authors.forename: Ido Didi
authors.initials: ID
authors.lastname: Fabian
mesh_terms: D000268:Adhesiveness; D000818:Animals; D001918:Brachytherapy / Q000379:methods*; D015353:Eye Enucleation; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D008545:Melanoma / Q000532:radiotherapy*; D012590:Sclera / Q000187:drug effects; D034421:Sus scrofa; D014014:Tissue Adhesives / Q000494:pharmacology*; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*; D014604:Uveal Neoplasms / Q000532:radiotherapy*; D000098943:Uveal Melanoma
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D014568:Urokinase-Type Plasminogen Activator