title: Treatment of Gastric Metaplasia or Dysplasia by Endoscopic Radiofrequency Ablation: A Pilot Study.
abstract: OBJECTIVE
  Patients with gastric intestinal metaplasia and dysplasia are at increased risk of gastric cancer development. We tested the feasibility of using endoscopic radiofrequency ablation for the treatment of dysplasia and metaplasia in the stomach.
  
  
  METHODS
  Patients who had histologically confirmed low-grade gastric dysplasia or IM were recruited. Endoscopic RFA was performed at 8 week-intervals for a maximum of 3 sessions. All patients were followed up by endoscopy until 12 months post-RFA. The primary outcome was the complete eradication of dysplasia or IM on follow-up. Secondary outcome was adverse events related to RFA.
  
  
  RESULTS
  A total of 12 patients were recruited. Four patients had low-grade dysplasia and the remaining 8 patients had non-dysplastic IM at baseline. At one year after RFA, complete eradication of dysplasia was noted in four patients with low-grade dysplasia (100%). Gastric IM persisted in all patients with baseline metaplasia but the severity of IM improved in 6 (75%) patients. Endoscopic RFA was safe with minimal complications encountered.
  
  
  CONCLUSIONS
  RFA successfully eradicated low-grade dysplasia of the stomach. Gastric IM however persisted after RFA but most patients had evidence of histological improvement on follow up.
authors.forename: Wai K
authors.initials: WK
authors.lastname: Leung
authors.forename: Daniel K H
authors.initials: DK
authors.lastname: Tong
authors.forename: Suet Yi
authors.initials: SY
authors.lastname: Leung
authors.forename: Fion S Y
authors.initials: FS
authors.lastname: Chan
authors.forename: Teresa S M
authors.initials: TS
authors.lastname: Tong
authors.forename: Ronnie S L
authors.initials: RS
authors.lastname: Ho
authors.forename: Kent Man
authors.initials: KM
authors.lastname: Chu
authors.forename: Simon Y K
authors.initials: SY
authors.lastname: Law
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D005773:Gastroscopy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D010865:Pilot Projects; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D012307:Risk Factors; D013270:Stomach / Q000473:pathology / Q000601:surgery*; D013272:Stomach Diseases / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome