title: Histopathological and Immunohistochemical Evaluation of Meningiomas with Reference to Proliferative Markers p53 and Ki-67.
abstract: BACKGROUND
  Meningiomas are slow growing primary central nervous system (CNS) tumours attached to the duramater, which arise from the meningothelial cells of the arachnoid. Grading of meningioma based on histological findings assisted with supplementary immunohistochemical studies, predicts the prognosis of meningioma with good precision.
  
  
  OBJECTIVE
  To evaluate proliferative markers and correlate with various histological subtypes and grade.
  
  
  METHODS
  A total of 224 meningiomas, diagnosed between January1995 and October 2011were graded according to WHO 2007 criteria. Immunostaining for p53 and Ki-67 markers were performed on 100 cases.
  
  
  RESULTS
  There was female predominance. There were 194 Grade I, 24 Grade II and 6 Grade III meningiomas. Brain invasion noted in 18(8%) meningiomas predominantly in grade III followed by grade II. Recurrence was seen in 7 (3.1%) cases, most common in psammomatous followed by angiomatous meningioma. Immunostaining showed p53 positivity in 72.5% of grade I, 83.3% of grade II and all the cases of grade III tumours. Ki-67 Labelling Index (LI) consistently increased from grade I to grade III tumours.
  
  
  CONCLUSIONS
  p53 and Ki-67 LI correlated well with increasing histological grade and biological behaviour of meningioma.
authors.affiliation: Assistant Professor, Department of Pathology, Christian Medical College Hospital , Vellore, Tamilnadu, India .
authors.forename: Ramesh Babu
authors.initials: RB
authors.lastname: Telugu
authors.affiliation: Associate Professor, Department of Pathology, SVIMS , Tirupati, Andhra Pradesh, India .
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Chowhan
authors.affiliation: Associate Professor, Department of Pathology, SVIMS , Tirupati, Andhra Pradesh, India .
authors.forename: Nandyala
authors.initials: N
authors.lastname: Rukmangadha
authors.affiliation: Associate Professor, Department of Pathology, SVIMS , Tirupati, Andhra Pradesh, India .
authors.forename: Rashmi
authors.initials: R
authors.lastname: Patnayak
authors.affiliation: Professor, Department of Pathology, SVIMS , Tirupati, Andhra Pradesh, India .
authors.forename: Bobbidi Venkata
authors.initials: BV
authors.lastname: Phaneendra
authors.affiliation: Professor, Department of Neurosurgery, SVIMS , Tirupati, Andhra Pradesh, India .
authors.forename: Bodapati Chandra Mowliswara
authors.initials: BC
authors.lastname: Prasad
authors.affiliation: Professor, Department of Pathology, SVIMS , Tirupati, Andhra Pradesh, India .
authors.forename: Mandyam Kumaraswamy
authors.initials: MK
authors.lastname: Reddy
keywords: Antigen; Central nervous system neoplasms; Primary intracranial tumours