title: 3-Acylated tetramic and tetronic acids as natural metal binders: myth or reality?
abstract: Covering: up to 20153-Acylated tetramic and tetronic acids are characterized by a low pKa and are likely to be deprotonated under physiological conditions. In addition, their structure makes them excellent chelators of metallic cations. We will discuss the significance of these chemical properties with regard to the biological properties and mechanisms of action of these compounds, highlighting the importance of considering them as salts or chelates for biological purposes, rather than acids.
authors.affiliation: Muséum National d'Histoire Naturelle, CNRS, UMR 7245 Molécules de Communication et Adaptation des Micro-organismes, 57 rue Cuvier (CP 54), 75005 Paris, France. bnay@mnhn.fr.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Zaghouani
authors.forename: Bastien
authors.initials: B
authors.lastname: Nay
mesh_terms: D000215:Acylation; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001688:Biological Products; D005663:Furans; D011760:Pyrrolidinones; C009435:tetramic acid; C003422:tetronic acid