title: Changes in Oxidative Stress and Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetes Mellitus in Rats: Role of Alhagi maurorum Extracts.
abstract: Alhagi maurorum (camel thorn plant) is a promising medicinal plant due to the presence of flavonoids and phenolic compounds as major contents of its constituents. No previous study has been conducted before on A. maurorum extracts as an antioxidative stress and/or antidiabetic herb in STZ-induced DM in rats. Therefore, four groups of rats were allocated as control (C), STZ-induced DM (D), and STZ-induced DM supplemented with 300 mg/kg BW of either aqueous extract (WE) or ethanolic extract (EE) of A. maurorum. The plasma levels of glucose, TG, TC, LDL-C and VLDL-C, MDA, and bilirubin and the activities of transaminases and GR were significantly increased in the diabetic group. Also, diabetic rats showed severe glucose intolerance and histopathological changes in their livers. In addition, levels of insulin, total proteins, GSH, and HDL-C and the activities of SOD, GPx, and GST were significantly decreased in the diabetic rats compared to those of the control group. The ingestion of A. maurorum extracts lowered the blood glucose levels during the OGTT compared to the diabetic rats and restored all tested parameters to their normal levels with the exception of insulin level that could not be restored. It is concluded that A. maurorum extracts decreased elevated blood glucose levels and hyperlipidemia and suppressed oxidative stress caused by diabetes mellitus in rats.
authors.affiliation: Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Egypt.
authors.forename: S A
authors.initials: SA
authors.lastname: Sheweita
authors.affiliation: Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Egypt.
authors.forename: S
authors.initials: S
authors.lastname: Mashaly
authors.affiliation: Department of Biochemistry, Faculty of Science, Alexandria University, Egypt.
authors.forename: A A
authors.initials: AA
authors.lastname: Newairy
authors.affiliation: Department of Zoology, Faculty of Science, Alexandria University, Egypt.
authors.forename: H M
authors.initials: HM
authors.lastname: Abdou
authors.affiliation: Department of Biochemistry, Faculty of Science, Alexandria University, Egypt.
authors.forename: S M
authors.initials: SM
authors.lastname: Eweda
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000473:pathology*; D007887:Fabaceae / Q000737:chemistry*; D005215:Fasting / Q000097:blood; D005419:Flavonoids / Q000032:analysis; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000032:analysis; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013311:Streptozocin
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D005419:Flavonoids; D007328:Insulin; D010636:Phenols; D010936:Plant Extracts; D013311:Streptozocin