title: Kinetic analysis of nanoparticle-protein interactions using a plasmon waveguide resonance.
abstract: A plasmon waveguide resonance (PWR) sensor is proposed for studying the interaction between gold nanoparticles and proteins. The ability of the PWR sensor to operate in both TM and TE Polarizations, i.e. its polarization diversity, facilitates the simultaneous spectroscopy of the nanoparticles surface reactions using both polarizations. The response of each polarization to streptavidin-biotin binding at the surface of gold nanoparticles is investigated in real time. Finally, using the principles of multimode spectroscopy, the nanoparticle's surface reactions are decoupled from the bulk solution refractive index variations. Schematic diagram of the NP-modified PWR sensor.
authors.affiliation: Department of Electrical and Computer Engineering, University of Toronto, Ontario, M5S 3G4, Canada.
authors.forename: Farshid
authors.initials: F
authors.lastname: Bahrami
authors.affiliation: Department of Engineering Physics, EcolePolytechnique de Montreal, Montreal, H3C 3A7, Canada.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Maisonneuve
authors.affiliation: Department of Engineering Physics, EcolePolytechnique de Montreal, Montreal, H3C 3A7, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: Meunier
authors.affiliation: Department of Electrical and Computer Engineering, University of Toronto, Ontario, M5S 3G4, Canada.
authors.forename: Arthur O
authors.initials: AO
authors.lastname: Montazeri
authors.affiliation: Department of Electrical and Computer Engineering, University of Toronto, Ontario, M5S 3G4, Canada.
authors.forename: Yujin
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Electrical and Computer Engineering, University of Toronto, Ontario, M5S 3G4, Canada.
authors.forename: Nazir P
authors.initials: NP
authors.lastname: Kherani
authors.affiliation: Department of Electrical and Computer Engineering, University of Toronto, Ontario, M5S 3G4, Canada.
authors.forename: J Stewart
authors.initials: JS
authors.lastname: Aitchison
authors.affiliation: Department of Electrical and Computer Engineering, University of Toronto, Ontario, M5S 3G4, Canada.
authors.forename: Mo
authors.initials: M
authors.lastname: Mojahedi
mesh_terms: D006046:Gold; D007700:Kinetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D012031:Refractometry; D020349:Surface Plasmon Resonance
chemical_list: D011506:Proteins; D006046:Gold
keywords: Biosensing; Plasmon waveguide resonance; Protein-nanoparticle interactions; SPR sensor