title: Endophthalmitis of probable endogenous origin caused by Scedosporium boydii: A case report.
abstract: BACKGROUND
  Mycotic ocular infections caused by the Scedosporium apiospermum species complex are challenging to treat because of the delayed diagnoses and poor responses to antifungal drugs and surgical treatment.
  
  
  METHODS
  A case of a 69-year-old male patient with a history of diabetes mellitus type 2 and prior surgery on the right femur is described. In the 10 days prior to the ophthalmic consultation he started with ocular pain, adding to a previous and progressive loss of visual acuity in his right eye. The diagnosis of endophthalmitis of probable endogenous origin was established. Despite medical treatment, the patient's condition worsened and, due to the imminent risks, an enucleation was performed. Smears of the enucleation tissue revealed fungal cells, and the cultures yielded a fungus belonging to the S. apiospermum species complex, which was identified as Scedosporium boydii by morphological characteristics and sequencing of a PCR amplicon.
  
  
  CONCLUSIONS
  A diagnosis of endophthalmitis of probable endogenous origin in the right eye was based on a previous right femur surgery. Potential risk to the patient led to enucleation.
authors.affiliation: Laboratorio de Microbiología del Hospital Asociación para evitar la Ceguera en México, Mexico. Electronic address: vivanzzini@yahoo.com.
authors.forename: Virginia
authors.initials: V
authors.lastname: Vanzzini-Zago
authors.affiliation: Ophthalmic Pathology Chief, Instituto Mexicano de Oftalmología IAP Querétaro - Querétaro, Mexico.
authors.forename: Sonia
authors.initials: S
authors.lastname: Corredor-Casas
authors.affiliation: Laboratorio de Patología del Hospital Asociación para Evitar la Ceguera en México, Mexico.
authors.forename: Abelardo
authors.initials: A
authors.lastname: Rodríguez-Reyes
authors.affiliation: Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., Mexico.
authors.forename: Francisca
authors.initials: F
authors.lastname: Hernández-Hernández
authors.affiliation: Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., Mexico.
authors.forename: Patricia
authors.initials: P
authors.lastname: Manzano-Gayosso
authors.affiliation: Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., Mexico.
authors.forename: Rubén López
authors.initials: RL
authors.lastname: Martínez
authors.affiliation: Becario del Servicio de Retina del Hospital Asociación para evitar la Ceguera en México, Mexico.
authors.forename: Alan Ricardo Alba
authors.initials: AR
authors.lastname: Orozco
mesh_terms: D000368:Aged; D057210:Delayed Diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004198:Disease Susceptibility; D009877:Endophthalmitis / Q000175:diagnosis / Q000382:microbiology* / Q000601:surgery; D015353:Eye Enucleation; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000382:microbiology* / Q000601:surgery; D005269:Femur / Q000601:surgery; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis / Q000382:microbiology* / Q000601:surgery; D021681:Scedosporium / Q000302:isolation & purification*
keywords: Complejo de especies de Scedosporium apiospermum; Endoftalmitis fúngica; Enucleación; Enucleation; Fungal endophthalmitis; Micosis; Mycosis; Scedosporium apiospermum species complex