title: Chordoma in children: Case-report and review of literature.
abstract: We report an exceptional case of a very late local failure in a 9-year-old boy presenting with a chordoma of the cranio-cervical junction. The child was initially treated with a combination of surgical resection followed by high dose photon-proton radiation therapy. This aggressive therapy allowed a 9-year remission with minimal side-effects. Unfortunately, he subsequently presented with a local failure managed with a second full-dose course of protons. The child died one year later from local bleeding of unclear etiology.
authors.affiliation: Department of Radiation Oncology, Centre François Baclesse, 3 rue du Général Harris, 14076 Caen, France; Department of Radiation Oncology, Institut Curie Protontherapy Center, Campus universitaire, 91406 Orsay, France; Department of Radiation Oncology, Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94805 Villejuif, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Habrand
authors.affiliation: Department of Radiation Oncology, Centre François Baclesse, 3 rue du Général Harris, 14076 Caen, France; Department of Radiation Oncology, Institut Curie Protontherapy Center, Campus universitaire, 91406 Orsay, France; Department of Radiation Oncology, Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94805 Villejuif, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Datchary
authors.affiliation: Department of Radiation Oncology, Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94805 Villejuif, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Bolle
authors.affiliation: Department of Radiation Oncology, Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94805 Villejuif, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Beaudré
authors.affiliation: Department of Radiation Oncology, Institut Curie Protontherapy Center, Campus universitaire, 91406 Orsay, France.
authors.forename: Ludovic
authors.initials: L
authors.lastname: de Marzi
authors.affiliation: Department of Pediatric Neurosurgery, Centre Hospitalier Necker-Enfants Malades, 149 rue de Sèvres, 75015 Paris, France.
authors.forename: Kévin
authors.initials: K
authors.lastname: Beccaria
authors.affiliation: Department of Radiation Oncology, Centre François Baclesse, 3 rue du Général Harris, 14076 Caen, France.
authors.forename: Dinu
authors.initials: D
authors.lastname: Stefan
authors.affiliation: Department of Pediatric Oncology, Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94805 Villejuif, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Grill
authors.affiliation: Department of Radiation Oncology, Institut Curie Protontherapy Center, Campus universitaire, 91406 Orsay, France.
authors.forename: Rémi
authors.initials: R
authors.lastname: Dendale
keywords: Children; Chordoma; Protontherapy; Sarcoma