title: Risk Factors for Steatorrhea in Chronic Pancreatitis: A Cohort of 2,153 Patients.
abstract: This study aimed to investigate the occurrence of and determine the risk factors for steatorrhea in chronic pancreatitis (CP). It was based on analysis of both retrospectively and prospectively acquired database for CP patients admitted to our center from January 2000 to December 2013. Demographic data, course of disease, medical history, and follow-up evaluations of patients were documented in detail. Cumulative rate of steatorrhea was calculated by using the Kaplan-Meier method. For risk factor analysis, multivariate analysis by Cox proportional hazards regression model was performed. A total of 2,153 CP patients were included with a mean follow-up duration of 9.3 years. Approximately 14% (291/2,153) of CP patients presented with steatorrhea at diagnosis of CP. Cumulative rates of steatorrhea at 1, 5, 10, and 20 years after diagnosis of CP were 4.27% (95% CI: 3.42%-5.34%), 12.53% (95% CI: 10.74%-14.59%), 20.44% (95% CI: 17.37%-23.98%) and 30.82% (95% CI: 20.20%-45.21%), respectively. Male gender (HR = 1.771, p = 0.004), diabetes (HR = 1.923, p < .001), alcohol abuse (HR = 1.503, p = 0.025) and pancreaticoduodenectomy (HR = 2.901, p < 0.001) were independent risk factors for steatorrhea while CP in adolescents (HR = 0.433, p = 0.009) was a protective factor. In conclusion, male gender, adult, diabetes, alcohol abuse and pancreaticoduodenectomy lead to increased risk of steatorrhea in CP patients.
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.|Department of Gastroenterology, Air Force General Hospital, Beijing, China.
authors.forename: Bai-Rong
authors.initials: BR
authors.lastname: Li
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Du
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Zhuan
authors.initials: Z
authors.lastname: Liao
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Ye
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Zou
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Jun-Tao
authors.initials: JT
authors.lastname: Ji
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Zhao-Hong
authors.initials: ZH
authors.lastname: Zheng
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Jin-Huan
authors.initials: JH
authors.lastname: Lin
authors.affiliation: Department of Gastroenterology, Air Force General Hospital, Beijing, China.
authors.forename: Shou-Bin
authors.initials: SB
authors.lastname: Ning
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Liang-Hao
authors.initials: LH
authors.lastname: Hu
authors.affiliation: Department of Gastroenterology &Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Zhao-Shen
authors.initials: ZS
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000437:Alcoholism / Q000150:complications / Q000473:pathology; D015331:Cohort Studies; D048909:Diabetes Complications / Q000453:epidemiology* / Q000473:pathology; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050500:Pancreatitis, Chronic / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D045602:Steatorrhea / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology