title: Comparison of clinicopathological features of gastric carcinoma, between 2 times periods, at a single institute in China.
abstract: OBJECTIVE
  This study aims to compare the clinicopathological features of gastric carcinoma between two different time periods, and to investigate the prognostic factors for gastric carcinoma.
  
  
  METHODS
  One thousand sixteen consecutive gastric cancer patients were divided into two groups according to the operation date, period I (1994-1999) and period II (2000-2006). The clinicopathological features and prognosis were compared between the two periods.
  
  
  RESULTS
  There were significant differences in the proportions of early gastric carcinoma, different tumor node metastasis (TNM) staged patients, specialized operation and adjuvant chemotherapy between the two periods. The 5-year survival rate after curative resection within period II, were significantly higher than those within period I. Stratification analysis revealed that the survival rates of the patients with curative resection, lymph node metastasis, advanced disease, different TNM stages, specialized operations, without adjuvant chemotherapy within period II, were significantly higher than those within period I. Multivariate regression analysis revealed that Borrmann type, histologic type, depth of invasion, lymph node metastasis, curative resection, adjuvant chemotherapy, and different time periods were independent prognostic factors for gastric carcinoma.
  
  
  CONCLUSIONS
  The treatment efficacy of gastric carcinoma within the recent period improved highly when compared with that within the early period. It was the elevated diagnostic rate of early gastric cancer, standardized radical operation, and adjuvant chemotherapy that contributed to such improvement.
authors.forename: Chen
authors.initials: C
authors.lastname: Jianhui
authors.forename: He
authors.initials: H
authors.lastname: Yulong
authors.forename: Chen
authors.initials: C
authors.lastname: Chuangqi
authors.forename: Wu
authors.initials: W
authors.lastname: Kaiming
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xinhua
authors.affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China.
authors.forename: Cai
authors.initials: C
authors.lastname: Shirong
mesh_terms: D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000556:secondary* / Q000628:therapy; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology* / Q000628:therapy; D015996:Survival Rate; D013997:Time Factors