title: New theory of uterovaginal embryogenesis.
abstract: The explanation of uterine and vaginal embryogenesis in humans still poses many controversies, because it is difficult to assess early stages of an embryo. The literature review revealed many disagreements in Mullerian theory, inciting some authors to propose new embryological hypotheses. In the original Mullerian theory: the paramesonephral ducts form the Fallopian tubes, uterus and vagina; the mesonephral ducts regress in female embryos.
  
  
  
  The aim of this article is to investigate the development of Mullerian ducts in humans, using comparative analysis of fundamental embryological theory and various utero-vaginal anomalies.
  
  
  
  Between 1998 and 2015, 434 patients with various uterovaginal malformations had been operated on at the Scientific Centre of Obstetrics Gynaecology and Perynatology in Moscow. The anatomies of the uterovaginal malformations in these patients were diagnosed with ultrasound and MRI and then verified during surgical correction by laparoscopy.
  
  
  
  A systematic comparison of uterovaginal malformations to those in the literature has allowed us to formulate a new theory of embryonic morphogenesis. The new theory is significantly different: ovary, ovarian ligamentum proprium, and ligamentum teres uteri derive from gonadal ridges; Fallopian tubes and vagina completely develop from mesonephral ducts. The uterus develops in the area of intersection between the mesonephral ducts with gonadal ridges by the fusion of the two.
  
  
  
  The new theory may to induce future embryological studies. The hypothetic possibility that the ovary and endometrium derive from the gonadal ridges could be the key to understanding the enigmatic aetiologies of extragenital and ovarian endometriosis.
authors.affiliation: a Department of Operative Gynecology , Federal State Scientific Center of Obstetrics , Gynecology and Perynatology after V.I.Kulakov, Moscow , Russia.
authors.forename: Zograb
authors.initials: Z
authors.lastname: Makiyan
mesh_terms: D047108:Embryonic Development / Q000502:physiology*; D004715:Endometriosis; D005260:Female; D006801:Humans; D014599:Uterus / Q000196:embryology*; D014621:Vagina / Q000196:embryology*
keywords: Mullerian theory; embryogenesis research, endometriosis aetiology, extra genital endometriosis; new theory about uterovaginal organogenesis; uterovaginal anomalies; uterovaginal organogenesis