title: [Clinical significance of the preoperative neutrophil lymphocyte ratio in the evaluation of the prognosis of laryngeal carcinoma].
abstract: OBJECTIVE
  To explore the effect of preoperative neutrophil lymphocyte ratio (NLR) on the prognosis of patients with laryngeal carcinoma.
  
  
  METHODS
  Clinical data of 202 patients with laryngeal carcinoma treated from January 2004 to October 2009 were retrospective analyzed to determine the optimal critical value of NLR. To study whether NLR is an independent factor affecting the recurrence and 5-year survival rate of patients with laryngeal cancer after surgery, single factor and multivariate analyses were performed. The factors included age, gender, T stage, pathological differentiation, lymph node metastasis, primary tumor site and NLR value. The relationship between NLR and cervical lymph node metastasis was analyzed.
  
  
  RESULTS
  The optimal critical value of NLR was 2.85, by which cases were divided into high NLR group (NLR≥2.85) and low NLR group (NLR<2.85). Single factor and multivariate analyses indicated that T staging, lymph node metastasis, primary tumor location, and NLR were the independent factors affecting the recurrence of laryngeal carcinoma. T stage and lymph node metastasis were the independent factors affecting 5-year survival rate of laryngeal carcinoma. The increase of NLR value increased the rate of cervical lymph node metastasis.
  
  
  CONCLUSIONS
  Preoperative NLR level influences the recurrence and cervical lymph node metastasis of laryngeal carcinoma and can be considered a prognosis factor of laryngeal cancer.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Tangshan Xiehe Hospital, Tangshan 063000, China.
authors.forename: G F
authors.initials: GF
authors.lastname: Zhao
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Tangshan Xiehe Hospital, Tangshan 063000, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Hu
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, North China University of Science and Technology Hospital, Tangshan 063000, China.
authors.forename: R L
authors.initials: RL
authors.lastname: Liu
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Tangshan Xiehe Hospital, Tangshan 063000, China.
authors.forename: F
authors.initials: F
authors.lastname: Shi
authors.affiliation: Department of Ultrasonography, Tangshan Xiehe Hospital, Tangshan 063000, China.
authors.forename: H P
authors.initials: HP
authors.lastname: Li
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Tangshan Xiehe Hospital, Tangshan 063000, China.
authors.forename: D H
authors.initials: DH
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology, People's Hospital of Zunhua City, Tangshan 064200, China.
authors.forename: B C
authors.initials: BC
authors.lastname: Wang
mesh_terms: D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008214:Lymphocytes / Q000166:cytology*; D009333:Neck; D009364:Neoplasm Recurrence, Local; D009504:Neutrophils / Q000166:cytology*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate