title: Pim-1 kinase as cancer drug target: An update.
abstract: Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine kinase that regulates multiple cellular functions such as cell cycle, cell survival, drug resistance. Aberrant elevation of Pim-1 kinase is associated with numerous types of cancer. Two distinct isoforms of Pim-1 (Pim-1S and Pim-1L) show distinct cellular functions. Pim-1S predominately localizes to the nucleus and Pim-1L localizes to plasma membrane for drug resistance. Recent studies show that mitochondrial Pim-1 maintains mitochondrial integrity. Pim-1 is emerging as a cancer drug target, particularly in prostate cancer. Recently the potent new functions of Pim-1 in immunotherapy, senescence bypass, metastasis and epigenetic dynamics have been found. The aim of the present updated review is to provide brief information regarding networks of Pim-1 kinase and focus on its recent advances as a novel drug target.
authors.affiliation: Department of Biology, Nazarbayev University School of Science and Technology, Astana 010000, Republic of Kazakhstan.
authors.forename: Yernar
authors.initials: Y
authors.lastname: Tursynbay
authors.affiliation: Institute of International Medical Research, Department of Urology and Andrology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, P.R. China.
authors.forename: Jinfu
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Sun Yat-sen University, Guangzhou 510080, P.R. China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.affiliation: Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana 010000, Republic of Kazakhstan.
authors.forename: Tursonjan
authors.initials: T
authors.lastname: Tokay
authors.affiliation: Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana 010000, Republic of Kazakhstan.
authors.forename: Zhaxybay
authors.initials: Z
authors.lastname: Zhumadilov
authors.affiliation: Department of Urology, Tong Ji Hospital, Tong Ji University, Shanghai 200065, P.R. China.
authors.forename: Denglong
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Biology, Nazarbayev University School of Science and Technology, Astana 010000, Republic of Kazakhstan.
authors.forename: Yingqiu
authors.initials: Y
authors.lastname: Xie
keywords: Pim-1; drug target; mitochondrial Pim1; update