title: Anticonvulsant Effects of Combined Treatment with Citicoline and Valproate on the Model of Acute Generalized Convulsions Induced by Pentylenetetrazole in Wistar Rats.
abstract: We studied anticonvulsant effects of combined treatment with citicoline, a nootropic substance with neuroregenerative and neuroprotective activities, and valproate, an antiepileptic agent widely used in the treatment of epilepsy, on the model of pentylenetetrazole-induced (75 mg/kg, intraperitoneally) acute generalized convulsions in male Wistar rats. Combined treatment with citicoline and valproate in minimum effective doses (70 and 300 mg/kg, respectively) potentiated the anticonvulsant properties of both agents.
authors.affiliation: Research Institute of General Pathology and Pathophysiology, Moscow, Russia. karpovamn@gmail.com.
authors.forename: M N
authors.initials: MN
authors.lastname: Karpova
authors.affiliation: Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Kuznetsova
authors.affiliation: Department of Psychiatry, Addiction Medicine, and Medical Psychology, Tver' State Medical Academy, Ministry of Health of the Russian Federation, Tver', Russia.
authors.forename: K A
authors.initials: KA
authors.lastname: Zin'kovskii
authors.affiliation: Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Klishina
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D008297:Male; D018697:Nootropic Agents / Q000627:therapeutic use*; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D018697:Nootropic Agents; D003566:Cytidine Diphosphate Choline; D014635:Valproic Acid; D010433:Pentylenetetrazole
keywords: citicoline; convulsions; epilepsy; nootropic substances; valproate