title: Hip Fracture Surgery and Survival in Centenarians.
abstract: Hip fracture (HF) is increasingly frequent with advancing age. Studies describing the HF incidence rate and survival after surgery in centenarians are scanty. To fill this gap, we performed a large population-based investigation on Lombardy centenarians (Italy).
  
  
  
  Retrospective observational cohort study based on information from the Healthcare Utilization Database. Among the cohort of 7,830 residents that reached 100 years of age between 2004 and 2011, incidence rate of HF was calculated. Two hundred fifty-nine patients were discharged alive from a hospital after HF and surgical repair (HF cohort). For each HF cohort member, a control was randomly selected from the initial cohort to be matched for gender and date of birth, and who did not experience HF from the date of their hundredth birthday until the date of hospital discharge of the corresponding HF cohort member. The survival curves and the hazard functions of HF and control cohort were calculated within 2 years.
  
  
  
  Over a mean follow-up of 1.85 years, HF incidence rate was 23.1 per 1,000 centenarians per year. Survival probability was significantly lower in HF cohort than in control cohort (31.5 vs 48.1%, p < .001). Hazard functions showed an increased risk of death in HF cohort than in control cohort, especially in the 3 months after surgery.
  
  
  
  Survival analysis exhibited an excess mortality in the first 3 months among HF cohort members, but not beyond this period. Every effort to counteract HF is warranted, including prevention of falls and high quality of care, especially in the early postsurgical time.
authors.affiliation: School of Medicine and Surgery, University of Milano-Bicocca, Italy. paolo.mazzola@unimib.it.|Geriatric Clinic, San Gerardo University Hospital, Monza, Italy.|Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York.|NeuroMI - Milan Center for Neuroscience, Clinical Neurosciences Research Area, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Mazzola
authors.affiliation: Division of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Rea
authors.affiliation: Operative Unit of Territorial Health Services, Region Lombardia, Milano, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Merlino
authors.affiliation: School of Medicine and Surgery, University of Milano-Bicocca, Italy.|Geriatric Clinic, San Gerardo University Hospital, Monza, Italy.|NeuroMI - Milan Center for Neuroscience, Clinical Neurosciences Research Area, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bellelli
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Lauren
authors.initials: L
authors.lastname: Dubner
authors.affiliation: Division of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Corrao
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York.|Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, New York.
authors.forename: Giulio M
authors.initials: GM
authors.lastname: Pasinetti
authors.affiliation: School of Medicine and Surgery, University of Milano-Bicocca, Italy.|NeuroMI - Milan Center for Neuroscience, Clinical Neurosciences Research Area, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Annoni
mesh_terms: D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006620:Hip Fractures / Q000453:epidemiology / Q000401:mortality* / Q000601:surgery*; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: Centenarians; Hip fracture; Hip fracture surgery; Orthogeriatric; Survival