title: The risk of bradykinin B2 receptor-58T/C gene polymorphism on hypertension: a meta-analysis.
abstract: BACKGROUND
  The risk of bradykinin B2 receptor (BDKRB2) -58T/C gene polymorphism on hypertension remains controversial.
  
  
  METHODS
  The Cochrane Library, Chinese Biomedical Database, EBSCO, Embase, ISI, MEDLINE, and PubMed were retrieved, and relevant articles were selected.
  
  
  RESULTS
  The significant association between BDKRB2-58T/C gene polymorphism and risk of hypertension were found under C-allele comparison [odds ratio (OR): 1.22, 95% confidential intervals (CI): 1.05-1.42, recessive model (OR: 1.32, 95% CI: 1.07-1.64), dominant model (OR: 0.74, 95% CI: 0.58-0.94), homozygote model (OR: 1.66, 95% CI: 1.11-2.47) and heterozygote model (OR: 1.23, 95% CI: 1.06-1.43). The magnitude of the association between the BDKRB2-58T/C gene polymorphism and risk of hypertension was substantiated in Asians under C-allele comparison (OR: 1.24, 95% CI: 1.04-1.49), recessive model (OR: 1.39, 95% CI: 1.04-1.86), dominant model (OR: 0.72, 95% CI: 0.56-0.93), homozygote model (OR: 1.78, 95% CI: 1.09-2.90) and heterozygote model (OR: 1.26, 95% CI: 1.07-1.49). No publication bias was found in the meta-analysis.
  
  
  CONCLUSIONS
  The meta-analysis suggested -58C allele and -58CC genotype increase the risk of hypertension. Inversely, -58TT genotype decreases the risk of hypertension.
authors.affiliation: Medical Center of The Graduate School, Nanchang University China.
authors.forename: Kaiping
authors.initials: K
authors.lastname: Luo
authors.affiliation: Medical Center of The Graduate School, Nanchang University China.
authors.forename: Wenling
authors.initials: W
authors.lastname: Kang
authors.affiliation: Department of Nephrology, Second Affiliated Hospital, Nanchang University China.
authors.forename: Gaosi
authors.initials: G
authors.lastname: Xu
keywords: Bradykinin B2 receptor; hypertension; meta-analysis; polymorphism