title: [Complete atrioventricular septal defect: a clinicopathologic study of 35 cases].
abstract: OBJECTIVE
  To investigate the autopsy characteristics, pathologic type, malfomation and genetic characteristics of complete atrioventricular septal defect (CAVSD).
  
  
  METHODS
  Thirty five cases of CAVSD were collected from Maternal and Child Hospital of Haidian District during Jan.2003 to Jan.2015. Autoptic material, clinical history and chromosome examination were reviewed.
  
  
  RESULTS
  Among 35 cases of CAVSD between 18-38 gestational weeks, there were 26 cases with CAVSD A (74.3%, 26/35), 1 case with CAVSD B (2.8%, 1/35) and 8 cases with CAVSD C (22.8%, 8/35). Only CAVSD malformation was seen in 4 cases (11.4%, 4/35). Multiple malformations were seen in 31 cases (88.6%, 31/35). Combined malformations most frequently occurred in cardiovascular, respiratory and locomotor system. Among 15 cases with chromosome examination, chromosome aberrations was found in 13 cases (13/15) and trisomy-21 was found in 11 cases (11/15).
  
  
  CONCLUSIONS
  CAVSD is a rare disease and CAVSD A is the most common type. CAVSD is usually combined with other malformations and chromosome aberrations.
authors.affiliation: Department of Pathology, Maternal and Child Hospital of Haidian District, Beijing 100080, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Zhong
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Gu
authors.forename: Aichun
authors.initials: A
authors.lastname: Wang
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Sun
authors.forename: Yingnan
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhang
authors.forename: Junling
authors.initials: J
authors.lastname: Xie
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics / Q000473:pathology; D001344:Autopsy; D002869:Chromosome Aberrations; D005865:Gestational Age; D006343:Heart Septal Defects; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000235:genetics / Q000473:pathology*