title: Characterization of tau positron emission tomography tracer [18F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias.
abstract: Aggregation of tau is a hallmark of many neurodegenerative diseases, and tau imaging with positron emission tomography (PET) may allow early diagnosis and treatment monitoring. We assessed binding of the PET tracer [18F]AV-1451 in a range of dementias.
  
  
  
  Phosphorimaging was used to quantify binding to postmortem brain tissue from 33 patients with different, histopathologically characterized, neurodegenerative dementias.
  
  
  
  [18F]AV-1451 showed high specific binding in cases with Alzheimer's disease (AD), moderate binding in Pick's disease and frontotemporal dementia with parkinsonism-17, and low but displaceable binding in corticobasal degeneration, progressive supranuclear palsy, non-tau proteinopathies, and in controls without pathology. Tracer binding did not correlate with tau load within disease groups.
  
  
  
  [18F]AV-1451 binds to tau in AD, and some other tauopathies. However, evidence for a non-tau binding site and lack of correlation between tracer binding and antibody staining suggest that reliable quantification of tau load with this tracer is problematic.
authors.affiliation: Institute of Nuclear Medicine and Department of Chemistry, University College London, London, UK.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Sander
authors.affiliation: Institute of Neurology, Department of Molecular Neuroscience, Queen Square Brain Bank, University College London, London, UK.
authors.forename: Tammaryn
authors.initials: T
authors.lastname: Lashley
authors.affiliation: Institute of Neurology, Department of Molecular Neuroscience, Queen Square Brain Bank, University College London, London, UK.
authors.forename: Priya
authors.initials: P
authors.lastname: Gami
authors.affiliation: Institute of Nuclear Medicine and Department of Chemistry, University College London, London, UK.
authors.forename: Thibault
authors.initials: T
authors.lastname: Gendron
authors.affiliation: Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
authors.forename: Mark F
authors.initials: MF
authors.lastname: Lythgoe
authors.affiliation: Institute of Neurology, Department of Neurodegenerative Disease, Dementia Research Centre, University College London, London, UK.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Rohrer
authors.affiliation: Institute of Neurology, Department of Neurodegenerative Disease, Dementia Research Centre, University College London, London, UK.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Schott
authors.affiliation: Institute of Neurology, Department of Molecular Neuroscience, Queen Square Brain Bank, University College London, London, UK.
authors.forename: Tamas
authors.initials: T
authors.lastname: Revesz
authors.affiliation: Institute of Neurology, Department of Neurodegenerative Disease, Dementia Research Centre, University College London, London, UK.
authors.forename: Nick C
authors.initials: NC
authors.lastname: Fox
authors.affiliation: Institute of Nuclear Medicine and Department of Chemistry, University College London, London, UK. Electronic address: e.arstad@ucl.ac.uk.
authors.forename: Erik
authors.initials: E
authors.lastname: Årstad
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D002243:Carbolines; D003704:Dementia / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography; D020033:Protein Isoforms; D019275:Radiopharmaceuticals; D016875:tau Proteins / Q000378:metabolism
chemical_list: D002243:Carbolines; C054369:MAPT protein, human; D020033:Protein Isoforms; D019275:Radiopharmaceuticals; D016875:tau Proteins; C000591008:7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole
keywords: Dementia; Immunohistochemistry; Neurodegeneration; PET; Phosphorimaging; Tau; [(18)F]AV-1451