title: NEW APPLICATIONS OF ADAPTOGENS TO REDUCE RADIATION SIDE EFFECTS.
abstract: One of the live medical issues today is to find medication to prevent adverse effects of ionizing radiation on the immune and hematopoietic systems. In Yakutia where in most of its regions the overall environmental situation is getting worse due to the development of natural deposits including radioactive deposits, this problem remains vital. The purpose of this work is to study radioprotective properties of adaptogens in the case of the hematopoietic system under irradiation. The studies were conducted on certain groups of hybrid mice. We used the methods of radiation exposure by a radiological apparatus RUM-25 on hybrid mice followed by studying the cellularity of bone marrow, spleen and thymus. The functional activity of all compartments of early hematopoiesis (bone marrow hematopoiesis) was identified by the exogenous colony forming method. The study found that the extracts of reindeer and moose antlers have a stimulating effect on the functional activity of the hematopoietic precursors in response to radiation. The study medication stimulates regeneration processes in the thymus and bone marrow after irradiation. Further, the adaptogens stimulatory effect on CFU functional activity was identified. The most pronounced effect has the extracts of reindeer antlers "Epsorin".
authors.forename: S N
authors.initials: SN
authors.lastname: Alekseeva
authors.forename: U D
authors.initials: UD
authors.lastname: Antipina
authors.forename: L I
authors.initials: LI
authors.lastname: Arzhakova
authors.forename: S V
authors.initials: SV
authors.lastname: Protodyakonov
mesh_terms: D000818:Animals; D000999:Antlers; D001110:Arctic Regions; D001853:Bone Marrow / Q000528:radiation effects*; D006410:Hematopoiesis / Q000528:radiation effects*; D006801:Humans; D007107:Immune System / Q000528:radiation effects*; D051379:Mice; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D044382:Population Groups; D000069079:Radiation Exposure / Q000009:adverse effects*; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology; D012053:Reindeer; D012426:Russia
chemical_list: D010936:Plant Extracts