title: Nasal NK/T cell lymphoma presents with long-term nasal blockage and fever: a rare case report and literature review.
abstract: NK/T cell lymphoma (NKTCL) is a common disease which is a threat to human health. Nasal NKTCL is a rare but serious type of systemic lymphoma because of its high mortality rate and serious complications. In this case report, we describe a male who presented with nasal blockage in the right side, a fever of one month duration and a soy-like, painless and gradually increasing mass in the right submandibular region due to nasal NKTCL. The patient had no significant medical history and the initial clinical symptoms were nasal blockage. Contrast computed tomography showed that the nasopharyngeal mucosa was thickened and that the celiac and retroperitoneal lymphaden was intumescent. Finally a biopsy, guided by nasal endoscopy and examined using flow cytometry confirmed a diagnosis of NKTCL. Nasal NKTCL is rare and has no unique characteristics at first presentation, such as epidemiology and obvious clinical manifestation. As no effective therapy is currently available for this disease, early diagnosis and therapy of nasal NKTCL remains challenging.
authors.affiliation: Department of Infection Diseases, Zhejiang Provincial People's Hospital, Hangzhou, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Zou
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Ke-Hua
authors.initials: KH
authors.lastname: Pan
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Infection Diseases, Zhejiang Provincial People's Hospital, Hangzhou, China.
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Pan
authors.affiliation: Department of Cardiovascular Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China.
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Ding
authors.affiliation: Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.|Institute of Hepatology, Wenzhou Medical University, Wenzhou, China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D016399:Lymphoma, T-Cell / Q000473:pathology* / Q000628:therapy; D008297:Male; D009297:Nasal Mucosa / Q000473:pathology*; D015508:Nasal Obstruction / Q000000981:diagnostic imaging / Q000473:pathology*; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D055611:Natural Killer T-Cells / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: NK/T cell lymphoma; clinical manifestation; fever of unknown origin