title: Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction.
abstract: Patients with severe aortic stenosis (AS) and left ventricular systolic dysfunction pose a significant challenge to the managing physician. Conventional pharmacological therapy for systolic heart failure has not been proven beneficial in this setting. Ivabradine, a selective current inhibitor, decreases the spontaneous firing rate of sinoatrial nodal cells, thereby reducing the heart rate, and has been shown to reduce a composite end-point of heart failure hospitalization and mortality in patients with impaired left ventricular function. Herein are reported details of the hemodynamic effects and clinical outcome of ivabradine treatment in an 86-year-old man with severe AS and severe left ventricular systolic function.
authors.forename: Duo
authors.initials: D
authors.lastname: Huang
authors.forename: Pak-Hei
authors.initials: PH
authors.lastname: Chan
authors.forename: Chi-Cheung
authors.initials: CC
authors.lastname: Lam
authors.forename: Puigi Catherine
authors.initials: PC
authors.lastname: Shea
authors.forename: Kai-Hang
authors.initials: KH
authors.lastname: Yiu
authors.forename: Hung-Fat
authors.initials: HF
authors.lastname: Tse
authors.forename: Chung-Wah
authors.initials: CW
authors.lastname: Siu
mesh_terms: D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D001552:Benzazepines / Q000627:therapeutic use*; D006328:Cardiac Catheterization / Q000379:methods; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D004562:Electrocardiography; D054143:Heart Failure, Systolic / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D000077550:Ivabradine; D008297:Male; D020127:Recovery of Function; D012720:Severity of Illness Index; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000503:physiopathology*; D016277:Ventricular Function, Left
chemical_list: D001552:Benzazepines; D002317:Cardiovascular Agents; D000077550:Ivabradine