title: Hyperresistinemia and metabolic dysregulation: a risky crosstalk in obese breast cancer.
abstract: Breast cancer is the most common malignancy among women worldwide. There is extensive literature on the relationship between body weight and breast cancer risk but some doubts still remain about the role of adipokines per se, the role of insulin and glucose regardless of obesity, as well as the crosstalk between these players. Thus, in this study, we intend to determine the relation between body mass index (BMI), glycaemia, insulinemia, insulin-resistance, blood adipokine levels and tumour characteristics in a Portuguese group of pre- and postmenopausal overweight/obese women with breast cancer. We evaluated clinical and biochemical data in 154 participants, divided in 4 groups: (1) control with BMI <25 kg/m(2), n = 29 (CT); (2) control with BMI >25 kg/m(2), n = 48 (CTOb); (3) breast cancer with BMI <25 kg/m(2), n = 30 (BC); and (4) breast cancer with BMI >25 kg/m(2), n = 47 (BCOb). In women with breast cancer, we also performed tumour characterization. We found that BCOb present increased fasting blood glucose, insulin, resistin and monocyte chemoattractant protein 1, insulin resistance and more aggressive tumours. Notably, this profile is not correlated with BMI, proposing the involvement of other processes than adiposity. Altogether, our results suggest that glucose dysmetabolism, insulin resistance and changes in adipokine secretion, in particular resistin, may be involved in the development and progression of breast cancer in overweight/obese pre- and postmenopausal women.
authors.affiliation: Laboratory of Physiology, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine of University of Coimbra, Coimbra, Portugal. joanacrisostomo@hotmail.com.
authors.forename: Joana
authors.initials: J
authors.lastname: Crisóstomo
authors.affiliation: Laboratory of Physiology, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine of University of Coimbra, Coimbra, Portugal.|Department of Complementary Sciences, Coimbra Health School, Instituto Politécnico de Coimbra, Coimbra, Portugal.
authors.forename: Paulo
authors.initials: P
authors.lastname: Matafome
authors.affiliation: Laboratory of Physiology, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine of University of Coimbra, Coimbra, Portugal.
authors.forename: Daniela
authors.initials: D
authors.lastname: Santos-Silva
authors.affiliation: Laboratory of Physiology, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine of University of Coimbra, Coimbra, Portugal.
authors.forename: Ana L
authors.initials: AL
authors.lastname: Gomes
authors.affiliation: Department of Internal Medicine, University Hospital Centre of Coimbra, Coimbra, Portugal.
authors.forename: Manuel
authors.initials: M
authors.lastname: Gomes
authors.affiliation: Laboratory of Biostatistics and Medical Informatics, IBILI, Faculty of Medicine of University of Coimbra, Coimbra, Portugal.
authors.forename: Miguel
authors.initials: M
authors.lastname: Patrício
authors.affiliation: Laboratory of Physiology, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine of University of Coimbra, Coimbra, Portugal.|Department of Neurology, University Hospital Centre of Coimbra, Coimbra, Portugal.
authors.forename: Liliana
authors.initials: L
authors.lastname: Letra
authors.affiliation: Laboratory of Oncology and Hematology, Applied Molecular Biology and University Clinic of Hematology, Faculty of Medicine of University of Coimbra, Coimbra, Portugal.|Center of Investigation in Environment, Genetic and Oncobiology, Faculty of Medicine of University of Coimbra, Coimbra, Portugal.|Department of Hematology, University Hospital Centre of Coimbra, Coimbra, Portugal.|CNC-IBILI, Faculty of Medicine of University of Coimbra, Coimbra, Portugal.
authors.forename: Ana B
authors.initials: AB
authors.lastname: Sarmento-Ribeiro
authors.affiliation: Department of Internal Medicine, University Hospital Centre of Coimbra, Coimbra, Portugal.
authors.forename: Lelita
authors.initials: L
authors.lastname: Santos
authors.affiliation: Laboratory of Physiology, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine of University of Coimbra, Coimbra, Portugal.
authors.forename: Raquel
authors.initials: R
authors.lastname: Seiça
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001943:Breast Neoplasms / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D052243:Resistin / Q000378:metabolism*
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin
keywords: Breast cancer; Glucose; Insulin; Resistin