title: Obesity Reduces Cognitive and Motor Functions across the Lifespan.
abstract: Due to a sedentary lifestyle, more and more people are becoming obese nowadays. In addition to health-related problems, obesity can also impair cognition and motor performance. Previous results have shown that obesity mainly affects cognition and motor behaviors through altering brain functions and musculoskeletal system, respectively. Many factors, such as insulin/leptin dysregulation and inflammation, mediate the effect of obesity and cognition and motor behaviors. Substantial evidence has suggested exercise to be an effective way to improve obesity and related cognitive and motor dysfunctions. This paper aims to discuss the association of obesity with cognition and motor behaviors and its underlying mechanisms. Following this, mechanisms of exercise to improve obesity-related dysfunctions are described. Finally, implications and future research direction are raised.
authors.affiliation: Department of Neurology, The Affiliated Shenzhen Nanshan Hospital, Shenzhen University, Shenzhen 518000, China.
authors.forename: Chuanming
authors.initials: C
authors.lastname: Wang
authors.affiliation: Center for Brain Disorders and Cognitive Neuroscience, Shenzhen University, Shenzhen 518060, China; Department of Psychology, The Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: John S Y
authors.initials: JS
authors.lastname: Chan
authors.affiliation: Department of Neurology, Shenzhen Second People's Hospital, Shenzhen University, Shenzhen 518035, China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Ren
authors.affiliation: Center for Brain Disorders and Cognitive Neuroscience, Shenzhen University, Shenzhen 518060, China.
authors.forename: Jin H
authors.initials: JH
authors.lastname: Yan
mesh_terms: D003071:Cognition / Q000502:physiology*; D006801:Humans; D008136:Longevity / Q000502:physiology*; D009048:Motor Skills / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009765:Obesity / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D057185:Sedentary Behavior