title: Endocytic control of signaling at the plasma membrane.
abstract: Signaling is regulated by endocytosis at multiple levels along endocytic routes. Endocytic control of signaling starts already at the plasma membrane, where cells employ different mechanisms to finely tune the type and strength of signals emanating from the cell surface. Here, we will review some of the most recently described endocytic mechanisms controlling signaling at the plasma membrane, through the regulation of internalization dynamics and through the integration of different internalization pathways triggered by canonical chemical stimuli or physical forces.
authors.affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Barbieri
authors.affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Via di Rudinì 8, 20122 Milan, Italy; Istituto Europeo di Oncologia, Via Ripamonti 435, 20141 Milan, Italy. Electronic address: pierpaolo.difiore@ifom.eu.
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Di Fiore
authors.affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy. Electronic address: sara.sigismund@ifom.eu.
authors.forename: Sara
authors.initials: S
authors.lastname: Sigismund
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002966:Clathrin / Q000378:metabolism; D004705:Endocytosis; D015398:Signal Transduction
chemical_list: D002966:Clathrin