title: 3DBIONOTES: A unified, enriched and interactive view of macromolecular information.
abstract: With the advent of high throughput techniques like Next Generation Sequencing, the amount of biological information for genes and proteins is growing faster than ever. Structural information is also rapidly growing, especially in the cryo Electron Microscopy area. However, in many cases, the proteomic and genomic data are spread in multiple databases and with no simple connection to structural information. In this work we present a new web platform that integrates EMDB/PDB structures and UniProt sequences with different sources of protein annotations. The application provides an interactive interface linking sequence and structure, including EM maps, presenting the different sources of information at sequence and structural level. The web application is available at http://3dbionotes.cnb.csic.es.
authors.affiliation: GN7 of the Spanish National Institute for Bioinformatics (INB) and Biocomputing Unit, National Center of Biotechnology (CSIC)/Instruct Image Processing Center, C/Darwin n° 3, Campus of Cantoblanco, 28049 Madrid, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Tabas-Madrid
authors.affiliation: GN7 of the Spanish National Institute for Bioinformatics (INB) and Biocomputing Unit, National Center of Biotechnology (CSIC)/Instruct Image Processing Center, C/Darwin n° 3, Campus of Cantoblanco, 28049 Madrid, Spain. Electronic address: jsegura@cnb.csic.es.
authors.forename: J
authors.initials: J
authors.lastname: Segura
authors.affiliation: GN7 of the Spanish National Institute for Bioinformatics (INB) and Biocomputing Unit, National Center of Biotechnology (CSIC)/Instruct Image Processing Center, C/Darwin n° 3, Campus of Cantoblanco, 28049 Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Sanchez-Garcia
authors.affiliation: GN7 of the Spanish National Institute for Bioinformatics (INB) and Biocomputing Unit, National Center of Biotechnology (CSIC)/Instruct Image Processing Center, C/Darwin n° 3, Campus of Cantoblanco, 28049 Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Cuenca-Alba
authors.affiliation: GN7 of the Spanish National Institute for Bioinformatics (INB) and Biocomputing Unit, National Center of Biotechnology (CSIC)/Instruct Image Processing Center, C/Darwin n° 3, Campus of Cantoblanco, 28049 Madrid, Spain.
authors.forename: C O S
authors.initials: CO
authors.lastname: Sorzano
authors.affiliation: GN7 of the Spanish National Institute for Bioinformatics (INB) and Biocomputing Unit, National Center of Biotechnology (CSIC)/Instruct Image Processing Center, C/Darwin n° 3, Campus of Cantoblanco, 28049 Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Carazo
mesh_terms: D025601:Adenomatous Polyposis Coli Protein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000595:Amino Acid Sequence; D015703:Antigens, CD; D001483:Base Sequence; D015820:Cadherins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D030562:Databases, Protein; D044783:F-Box Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D020407:Internet; D008958:Models, Molecular; D011487:Protein Conformation; D040901:Proteomics / Q000706:statistics & numerical data*; D016283:Proto-Oncogene Proteins p21(ras) / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012984:Software; D013329:Structure-Activity Relationship
chemical_list: C555337:APC protein, human; D025601:Adenomatous Polyposis Coli Protein; D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; D018797:Cell Cycle Proteins; D044783:F-Box Proteins; C498960:FBXO5 protein, human; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)
keywords: Database integration; Protein annotations; Protein sequence; Protein structure