title: Endocrine autoimmunity in patients  with Latent Autoimmune Diabetes in Adults (LADA)  — association with HLA genotype.
abstract: BACKGROUND
  Latent autoimmune diabetes in adults (LADA) is a slow-developing form of autoimmune diabetes, characterised by the presence of type 1 diabetes-associated autoantibody and presentation at diagnosis similar to patients with type 2 diabetes. The aim of this study was to determine the prevalence of auto-antibodies related to endocrine autoimmune diseases in patients with LADA and to assess their association with HLA genotype.
  
  
  METHODS
  We evaluated the presence of anti-thyroglobulin (ATG), anti-thyroid peroxidase (ATPO), anti-tissue transglutaminase IgA (ATTA), and anti 21 hydroxylase (A21H) in 70 patients with LADA, 69 with Type 2 diabetes, and in 50 healthy controls HLA genotype was assed in subpopulation of sluclied subjects.
  
  
  RESULTS
  The presence of ATPO (28.6 vs. 10%); ATG (28.6 vs. 14%) was higher in patients with LADA in comparison to healthy controls and ATPO in comparison to patients with type 2 diabetes (38.6 vs. 17.4 %). In patients with LADA the presence of autoimmune thyroid autoantibodies was associated with newly diagnosed subclinical hypothyroidism; almost 7% of patients presented with high TSH. The presence of A21H (2.86 vs. 5.8 vs. 6.1%) and ATTA (2.86 vs. 4.3 vs. 6.0%) was not different between groups. Patients with high TSH level were positive for DQA1*0301 and DRB1*04 HLA genotype: DQB1*0201 and DQB1*02 were higher in patients positive for ATTA.
  
  
  CONCLUSIONS
  Patients with LADA have higher prevalence of thyroid autoimmune diseases. In patients with LADA similarly to type 1 genotype DQA1*0301 seems to CONFER susceptibility to thyroid autoimmunity, and DQB1*0201 to celiac disease.
authors.forename: Barbara
authors.initials: B
authors.lastname: Szepietowska
authors.forename: Natalia
authors.initials: N
authors.lastname: Wawrusiewicz-Kurylonek
authors.forename: Adam
authors.initials: A
authors.lastname: Krętowski
authors.forename: Maria
authors.initials: M
authors.lastname: Górska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Szelachowska
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D004700:Endocrine System Diseases / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D005260:Female; D005838:Genotype; D059848:HLA-DQ alpha-Chains / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D033862:Iron-Binding Proteins / Q000276:immunology; D000071698:Latent Autoimmune Diabetes in Adults / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013255:Steroid 21-Hydroxylase / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D059848:HLA-DQ alpha-Chains; D059811:HLA-DRB1 Chains; D033862:Iron-Binding Proteins; D013954:Thyroglobulin; C056658:TPO protein, human; D007453:Iodide Peroxidase; D013255:Steroid 21-Hydroxylase