title: Magnetic Nanoparticles with High Specific Absorption Rate at Low Alternating Magnetic Field.
abstract: This paper describes the synthesis and properties of a new type of magnetic nanoparticle (MNP) for use in the hyperthermia treatment of tumors. These particles consist of 2-4 nm crystals of gamma-Fe2O3gathered in 20-40 nm aggregates with a coating of carboxymethyl-dextran, producing a zetasize of 110-120 nm. Despite their very low saturation magnetization (1.5-6.5 emu/g), the specific absorption rate (SAR) of the nanoparticles is 22-200 W/g at applied alternating magnetic field (AMF) with strengths of 100-500 Oe at a frequency of 160 kHz.
authors.affiliation: Thayer School of Engineering, 14 Engineering Drive, Dartmouth College, Hanover, NH 03755.
authors.forename: K
authors.initials: K
authors.lastname: Kekalo
authors.affiliation: Thayer School of Engineering, 14 Engineering Drive, Dartmouth College, Hanover, NH 03755.
authors.forename: I
authors.initials: I
authors.lastname: Baker
authors.affiliation: Thayer School of Engineering, 14 Engineering Drive, Dartmouth College, Hanover, NH 03755.
authors.forename: R
authors.initials: R
authors.lastname: Meyers
authors.affiliation: Thayer School of Engineering, 14 Engineering Drive, Dartmouth College, Hanover, NH 03755.
authors.forename: J
authors.initials: J
authors.lastname: Shyong
keywords: Magnetic nanoparticles; hyperthermia treatment; specific absorption rate