title: The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty.
abstract: Aseptic loosening is a major cause of revision surgery of total hip arthroplasty (THA). Only few host factors affecting aseptic loosening have been identified until now, although they are urgently needed to identify and possibly treat those patients at higher risk for aseptic loosening. To determine whether the functional single nucleotide polymorphism (SNP) c.-938C>A (rs2279115), located in the promoter region of the BCL2 gene has an impact on aseptic loosening of THA we genotyped and analyzed 234 patients suffering from aseptic loosening and 231 patients after primary THA. The polymorphism is associated with risk for aseptic loosening with the CC genotype at highest risk for aseptic loosening, Odds Ratio CC vs. AA 1.93, 95%CI 1.15-3.25, p = 0.013. In contrast, low risk AA genotype carriers that still developed aseptic loosening showed a significantly shorter time to aseptic loosening than patients carrying the C allele (p = 0.004). These results indicate that the BCL2 -938C>A polymorphism influences the occurrence and course of aseptic loosening and suggests this polymorphism as an interesting candidate for prospective studies and analyses in THA registers.
authors.affiliation: Institute of Pharmacogenetics, University Hospital Essen, Essen, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Stelmach
authors.affiliation: Department of Orthopaedics and Trauma Surgery, University Hospital Essen, Essen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Wedemeyer
authors.affiliation: Institute of Pharmacogenetics, University Hospital Essen, Essen, Germany.|Department of Orthopaedics and Trauma Surgery, University Hospital Essen, Essen, Germany.
authors.forename: Lena
authors.initials: L
authors.lastname: Fuest
authors.affiliation: Institute of Pharmacogenetics, University Hospital Essen, Essen, Germany.|Department of Orthopaedics and Trauma Surgery, University Hospital Essen, Essen, Germany.
authors.forename: Gina
authors.initials: G
authors.lastname: Kurscheid
authors.affiliation: Department of Joint Surgery, Helios ENDO-Klinik, Hamburg, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Gehrke
authors.affiliation: Institute of Pharmacogenetics, University Hospital Essen, Essen, Germany.|Department of Anaesthesiology and Intensive Care, University Hospital Essen, Essen, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Klenke
authors.affiliation: Department of Orthopaedics and Trauma Surgery, University Hospital Essen, Essen, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Jäger
authors.affiliation: Department of Orthopaedics and Trauma Surgery, University Hospital Essen, Essen, Germany.
authors.forename: Max D
authors.initials: MD
authors.lastname: Kauther
authors.affiliation: Institute of Pharmacogenetics, University Hospital Essen, Essen, Germany.
authors.forename: Hagen S
authors.initials: HS
authors.lastname: Bachmann
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic; D016016:Proportional Hazards Models; D011475:Prosthesis Failure; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2