title: S100A7: A rAMPing up AMP molecule in psoriasis.
abstract: S100A7 (psoriasin), an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. An S100A7 overexpression may occur in response to inflammatory stimuli, such in psoriasis, a chronic inflammatory autoimmune-mediated skin disease. Increasing evidence suggests that S100A7 plays critical roles in amplifying the inflammatory process in psoriatic skin, perpetuating the disease phenotype. This review will discuss the interactions between S100A7 and cytokines in psoriatic skin. Furthermore, we will focus our discussion on regulation and functions of S100A7 in psoriasis. Finally, we will discuss the possible use of S100A7 as therapeutic target in psoriasis.
authors.affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Italy. Electronic address: f.damico@unict.it.
authors.forename: Fabio
authors.initials: F
authors.lastname: D'Amico
authors.affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Italy. Electronic address: eskarmoutsou@gmail.com.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Skarmoutsou
authors.affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Italy. Electronic address: m_granata@live.it.
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Granata
authors.affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Italy. Electronic address: chiara.trovato@yahoo.it.
authors.forename: Chiara
authors.initials: C
authors.lastname: Trovato
authors.affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Italy. Electronic address: g.rossi8817@gmail.com.
authors.forename: Giulio Antonino
authors.initials: GA
authors.lastname: Rossi
authors.affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Italy. Electronic address: clomazza@unict.it.
authors.forename: Maria Clorinda
authors.initials: MC
authors.lastname: Mazzarino
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D011565:Psoriasis / Q000276:immunology*; D000075023:S100 Calcium Binding Protein A7 / Q000276:immunology*
chemical_list: D023181:Antimicrobial Cationic Peptides; D016207:Cytokines; D000075023:S100 Calcium Binding Protein A7
keywords: Keratinocyte; Psoriasin; Psoriasis; S100A7