title: The intersection of obstructive lung disease and sleep apnea.
abstract: Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) have synergistic detrimental effects. Their comorbid association leads to compromised gas exchange (hypoxia and hypercapnia) and higher rates of morbidity and death. As our understanding of the pathophysiologic processes of sleep evolves, the relationship between OSA and obstructive lung diseases such as COPD ("overlap syndrome") or asthma ("alternative overlap syndrome") has become more apparent. The pathophysiology of the combined conditions and optimal management are still being defined, but the effect on quality of life and morbidity underscore the importance of proper diagnosis and appropriately tailored management in these patients.
authors.affiliation: Co-Director, Asthma Center, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA. E-mail: khatris@ccf.org.|Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Sumita B
authors.initials: SB
authors.lastname: Khatri
authors.affiliation: Medical Director, Sleep Medicine Center, and Chief, Sleep Medicine Section, Atlanta VA Medical Center, Atlanta, GA, USA. E-mail: oioac@yahoo.com.|Associate Professor of Medicine, Emory University, Atlanta, GA, USA.
authors.forename: Octavian C
authors.initials: OC
authors.lastname: Ioachimescu
mesh_terms: D001249:Asthma / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D045422:Continuous Positive Airway Pressure; D006801:Humans; D006935:Hypercapnia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D000860:Hypoxia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D010102:Oxygen Inhalation Therapy; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology* / Q000628:therapy