title: Case-control study on peroxisome proliferator-activated receptor gamma polymorphism and interaction with HDL on essential hypertension in Chinese Han.
abstract: OBJECTIVE
  To investigate the association of single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptors gamma (PPARG) with essential hypertension (EH) and additional role of gene- high-density lipoprotein cholesterol (HDL) interaction.
  
  
  METHODS
  A total of 1640 patients with EH (806 males, 834 females), with a mean age of 52.5±12.6 years, were selected, including 816 EH patients and 824 controls, who were enrolled from the community. Three SNPs were selected for genotyping in the case-control study: rs10865710, rs709158, rs1805192. Logistic regression model was used to examine the interaction between SNP and HDL on EH, odds ratio (OR) and 95% confidence interval (95% CI) were also calculated.
  
  
  RESULTS
  All genotypes were distributed according to Hardy-Weinberg equilibrium in controls. Logistic regression analysis showed an association between genotypes of variants in rs1805192 and decreased EH risk, EH risk was significantly lower in carriers of Ala allele of the rs1805192 polymorphism than those with Pro/Pro (Pro/Ala+ Ala/Ala versus Pro/Pro, adjusted OR (95% CI) =0.65 (0.53-0.83), after covariate adjustment. In addition, the Ala allele of the rs1805192 polymorphism was also associated with diastolic blood pressure (DBP), but not systolic blood pressure (SBP), we also found, by interaction analysis, combined effect of rs1805192 and HDL on EH risk after covariate adjustment.
  
  
  CONCLUSIONS
  Our results support an important association between rs1805192 minor allele (Ala allele) of PPARG and lower EH risk, the interaction analysis showed a combined effect of Ala- HDL on lower EH risk.
authors.affiliation: Department of Cardiac Surgery, The affiliated Hospital of Qingdao University, Qingdao 266003, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Cardiac Surgery, The affiliated Hospital of Qingdao University, Qingdao 266003, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Cardiac Surgery, Beijing Fuwai Hospital, Beijing 100037, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.affiliation: Department of Cardiac Surgery, Qingdao Fuwai Hospital, Qingdao 266034, China.
authors.forename: Xianyan
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Cardiac Surgery, Qingdao Fuwai Hospital, Qingdao 266034, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Cardiac Surgery, Qingdao Fuwai Hospital, Qingdao 266034, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
keywords: Essential hypertension; HDL; Interaction; PPAR-γ; Single nucleotide poly-; morphisms