title: Effect of Curcumin in Experimental Peritonitis.
abstract: Despite medical advancements, the inflammatory cascade and oxidative stress worsen the prognosis in most cases of peritonitis. Curcumin has emerged as a potential antioxidant and anti-inflammatory agent in few of the acute inflammatory and infective conditions. We examined the effect of intraperitoneal injection of curcumin in endotoxin-induced peritonitis in rats. The blood and peritoneal fluid samples were collected at 3 and 24 h following the induction of peritonitis. Animals were sacrificed at 24 h and the organs preserved. The histopathological report of lung, liver, and intestines in the curcumin-treated rats showed maintenance of tissue architecture to a large extent compared to the control group which showed massive congestion, hemorrhage, and necrosis. The blood and peritoneal fluid total count and differential neutrophil counts were significantly higher at 24 h of induction of peritonitis. Serum amyloid assay and lipid peroxidation were significantly lower, and myeloperoxidase assay was higher in the curcumin-treated group at the end of 24 h; thus, curcumin probably demonstrated a neutrophil-mediated immunopotentiation and anti-inflammatory action thereby protecting the animal from endotoxemia-induced multi-organ damage.
authors.affiliation: Department of Physiology, St. John's Medical College, John Nagar, Bangalore, 560034 Karnataka India.
authors.forename: Savitha
authors.initials: S
authors.lastname: D
authors.affiliation: St Johns Research Institute, Karnataka, India.
authors.forename: Indu
authors.initials: I
authors.lastname: Mani
authors.affiliation: Department of Pathology, St. John's Medical College, Karnataka, India.
authors.forename: Gayatri
authors.initials: G
authors.lastname: Ravikumar
authors.affiliation: Department of Physiology, St. John's Medical College, Karnataka, India.
authors.forename: Sandhya T
authors.initials: ST
authors.lastname: Avadhany
keywords: Anti-inflammatory; Curcumin; Immunopotentiation; Peritonitis