title: Inter-Strain Differences in Default Mode Network: A Resting State fMRI Study on Spontaneously Hypertensive Rat and Wistar Kyoto Rat.
abstract: Genetic divergences among mammalian strains are presented phenotypically in various aspects of physical appearance such as body shape and facial features. Yet how genetic diversity is expressed in brain function still remains unclear. Functional connectivity has been shown to be a valuable approach in characterizing the relationship between brain functions and behaviors. Alterations in the brain default mode network (DMN) have been found in human neuropsychological disorders. In this study we selected the spontaneously hypertensive rat (SHR) and the Wistar Kyoto rat (WKY), two inbred rat strains with close genetic origins, to investigate variations in the DMN. Our results showed that the major DMN differences are the activities in hippocampal area and caudate putamen region. This may be correlated to the hyperactive behavior of the SHR strain. Advanced animal model studies on variations in the DMN may have potential to shed new light on translational medicine, especially with regard to neuropsychological disorders.
authors.affiliation: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300, Taiwan.
authors.forename: Sheng-Min
authors.initials: SM
authors.lastname: Huang
authors.affiliation: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300, Taiwan.
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Wu
authors.affiliation: Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 404, Taiwan.
authors.forename: Shin-Lei
authors.initials: SL
authors.lastname: Peng
authors.affiliation: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300, Taiwan.
authors.forename: Hsu-Hsia
authors.initials: HH
authors.lastname: Peng
authors.affiliation: Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan.
authors.forename: Teng-Yi
authors.initials: TY
authors.lastname: Huang
authors.affiliation: Department of Nuclear Medicine, Chang Gung Memorial Hospital and University, Taoyuan 333, Taiwan.|Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital and University, Taoyuan 333, Taiwan.
authors.forename: Kung-Chu
authors.initials: KC
authors.lastname: Ho
authors.affiliation: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300, Taiwan.
authors.forename: Fu-Nien
authors.initials: FN
authors.lastname: Wang
mesh_terms: D000818:Animals; D002421:Caudate Nucleus / Q000502:physiology* / Q000503:physiopathology; D006624:Hippocampus / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000502:physiology* / Q000503:physiopathology; D011699:Putamen / Q000502:physiology* / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012146:Rest / Q000502:physiology; D013045:Species Specificity