title: A ventral salience network in the macaque brain.
abstract: Successful navigation of the environment requires attending and responding efficiently to objects and conspecifics with the potential to benefit or harm (i.e., that have value). In humans, this function is subserved by a distributed large-scale neural network called the "salience network". We have recently demonstrated that there are two anatomically and functionally dissociable salience networks anchored in the dorsal and ventral portions of the human anterior insula (Touroutoglou et al., 2012). In this paper, we test the hypothesis that these two subnetworks exist in rhesus macaques (Macaca mulatta). We provide evidence that a homologous ventral salience network exists in macaques, but that the connectivity of the dorsal anterior insula in macaques is not sufficiently developed as a dorsal salience network. The evolutionary implications of these finding are considered.
authors.affiliation: Department of Neurology, Massachusetts General Hospital/Harvard Medical School 02114.|Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, MA 02129.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Touroutoglou
authors.affiliation: California National Primate Research Center, Davis, California 95616.|University of California at Davis, Davis, California 95616.
authors.forename: Eliza
authors.initials: E
authors.lastname: Bliss-Moreau
authors.affiliation: Northeastern University, Boston, Massachusetts 02115.
authors.forename: Jiahe
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Laboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium.|Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, UK.|Neural Control of Movement Laboratory, Department of Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland.
authors.forename: Dante
authors.initials: D
authors.lastname: Mantini
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, MA 02129.|Laboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium.|Department of Radiology, Massachusetts General Hospital/Harvard Medical School 02114.
authors.forename: Wim
authors.initials: W
authors.lastname: Vanduffel
authors.affiliation: Department of Neurology, Massachusetts General Hospital/Harvard Medical School 02114.|Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, MA 02129.
authors.forename: Bradford C
authors.initials: BC
authors.lastname: Dickerson
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, MA 02129.|Northeastern University, Boston, Massachusetts 02115.|Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School 02129.
authors.forename: Lisa Feldman
authors.initials: LF
authors.lastname: Barrett
mesh_terms: D000818:Animals; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D008253:Macaca mulatta / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D013045:Species Specificity
keywords: Intrinsic functional connectivity; Resting state fMRI; Rhesus macaques; Salience network