title: [Early detection of sporadic pancreatic cancer].
abstract: Pancreatic cancer (PC) behaves very differently in comparison with other malignancies. Its prevalence continuously increases, mortality does not decrease, diagnosis is frequently late, radical surgery is limited to 15-20 % of patients, postoperative relapses are frequent, and chemotherapy has a palliative character. Preventive programs are the only possibility of improvement. In familial pancreatic cancer (FPC) the knowledge of the genetic mutation enables earlier entry of specialists into the surveillance program. The repeated use of high resolution imaging methods (including endoscopy and pancreatic cytology) may be followed by more frequent detection of the precursors and earlier stages of FPC. The identification of sporadic pancreatic cancer (SPC) depends fully on the construction of a multi-step and multi-disciplinary preventive program.
authors.forename: Přemysl
authors.initials: P
authors.lastname: Frič
authors.forename: Aleksi
authors.initials: A
authors.lastname: Šedo
authors.forename: Jan
authors.initials: J
authors.lastname: Škrha
authors.forename: Tomáš
authors.initials: T
authors.lastname: Zima
authors.forename: Petr
authors.initials: P
authors.lastname: Bušek
authors.forename: Pavel
authors.initials: P
authors.lastname: Škrha
authors.forename: Klára
authors.initials: K
authors.lastname: Kmochová
authors.forename: Martin
authors.initials: M
authors.lastname: Laclav
authors.forename: Bohuš
authors.initials: B
authors.lastname: Bunganič
authors.forename: Miroslav
authors.initials: M
authors.lastname: Zavoral
mesh_terms: D002277:Carcinoma / Q000175:diagnosis* / Q000235:genetics* / Q000517:prevention & control; D055088:Early Detection of Cancer; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000517:prevention & control; D018570:Risk Assessment; D012307:Risk Factors
keywords: early detection; early symptoms; pancreatogenic diabetes; risk factors; risk groups.; sporadic pancreatic cancer