title: Quality of life in patients with food allergy.
abstract: Food allergy has increased in developed countries and can have a dramatic effect on quality of life, so as to provoke fatal reactions. We aimed to outline the socioeconomic impact that food allergy exerts in this kind of patients by performing a complete review of the literature and also describing the factors that may influence, to a greater extent, the quality of life of patients with food allergy and analyzing the different questionnaires available. Hitherto, strict avoidance of the culprit food(s) and use of emergency medications are the pillars to manage this condition. Promising approaches such as specific oral or epicutaneous immunotherapy and the use of monoclonal antibodies are progressively being investigated worldwide. However, even that an increasing number of centers fulfill those approaches, they are not fully implemented enough in clinical practice. The mean annual cost of health care has been estimated in international dollars (I$) 2016 for food-allergic adults and I$1089 for controls, a difference of I$927 (95 % confidence interval I$324-I$1530). A similar result was found for adults in each country, and for children, and interestingly, it was not sensitive to baseline demographic differences. Cost was significantly related to severity of illness in cases in nine countries. The constant threat of exposure, need for vigilance and expectation of outcome can have a tremendous impact on quality of life. Several studies have analyzed the impact of food allergy on health-related quality of life (HRQL) in adults and children in different countries. There have been described different factors that could modify HRQL in food allergic patients, the most important of them are perceived disease severity, age of the patient, peanut or soy allergy, country of origin and having allergy to two or more foods. Over the last few years, several different specific Quality of Life questionnaires for food allergic patients have been developed and translated to different languages and cultures. It is important to perform lingual and cultural translations of existent questionnaires in order to ensure its suitability in a specific region or country with its own socioeconomic reality and culture. Tools aimed at assessing the impact of food allergy on HRQL should be always part of the diagnostic work up, in order to provide a complete basal assessment, to highlight target of intervention as well as to evaluate the effectiveness of interventions designed to cure food allergy. HRQL may be the only meaningful outcome measure available for food allergy measuring this continuous burden.
authors.affiliation: Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias. Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, Carretera de Alcalá-Meco s/n, 28085 Alcalá de Henares, Madrid, Spain.
authors.forename: Darío
authors.initials: D
authors.lastname: Antolín-Amérigo
authors.affiliation: Hospital del Sureste. Arganda del Rey, Unidad de Alergia, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Manso
authors.affiliation: Allergy Unit, Verona University and General Hospital, Verona, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Caminati
authors.affiliation: Servicio de Alergia, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: de la Hoz Caballer
authors.affiliation: Servicio de Alergia, Hospital Universitario Clínico San Carlos, Madrid, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Cerecedo
authors.affiliation: Unidad de Bioestadística Clínica, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Muriel
authors.affiliation: Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias. Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, Carretera de Alcalá-Meco s/n, 28085 Alcalá de Henares, Madrid, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Rodríguez-Rodríguez
authors.affiliation: Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias. Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, Carretera de Alcalá-Meco s/n, 28085 Alcalá de Henares, Madrid, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Barbarroja-Escudero
authors.affiliation: Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias. Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, Carretera de Alcalá-Meco s/n, 28085 Alcalá de Henares, Madrid, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Sánchez-González
authors.affiliation: Hospital del Sureste. Arganda del Rey, Unidad de Alergia, Madrid, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Huertas-Barbudo
authors.affiliation: Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias. Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, Carretera de Alcalá-Meco s/n, 28085 Alcalá de Henares, Madrid, Spain.
authors.forename: Melchor
authors.initials: M
authors.lastname: Alvarez-Mon
keywords: Anaphylaxis; Food allergy; Health-related quality of life (HRQL); Quality of life; Questionnaire; Specific questionnaire