title: Prognostic value of diffusion-weighted magnetic resonance imaging and18F-fluorodeoxyglucose-positron emission tomography/computed tomography after concurrent chemoradiotherapy in uterine cervical cancer.
abstract: To evaluate the prognostic value of diffusion-weighted imaging (DWI) and positron emission tomography/computed tomography (PET/CT) for predicting disease progression after concurrent chemoradiotherapy (CCRT) in cervical cancer.
  
  
  
  A total of 67 locally advanced cervical cancer patients who received CCRT underwent both DWI and PET/CT before and during (at 1month) treatment. The mean apparent diffusion coefficient (ADCmean) and maximum standardized uptake value (SUVmax) were measured on the tumor and the percentage changes between 2 time points (ΔADCmeanand ΔSUVmax) were calculated. The ΔADCmeanand ΔSUVmaxwere compared in terms of predicting disease progression after CCRT.
  
  
  
  During a mean follow-up of 2.7years, disease progression was identified in 16 patients (23.9%). The ΔADCmeanand ΔSUVmaxwere significantly correlated (Spearman correlation coefficient, 0.38; P=0.002). For predicting disease progression, the integrated area under the curves of ΔADCmean(0.791) and ΔSUVmax(0.781) were not significantly different (P=0.88). On multivariate analysis, both ΔADCmeanand ΔSUVmaxwere the independent predictors of disease progression (hazard ratio, 7.9 and 8.7; P, 0.001 and <0.001, respectively).
  
  
  
  The percentage changes of ADCmeanand SUVmaxduring CCRT have a similar prognostic value for predicting disease progression after CCRT in cervical cancers.
authors.affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Jung Jae
authors.initials: JJ
authors.lastname: Park
authors.affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Medical Device Management & Research, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Electronic address: chankyokim@skku.edu.
authors.forename: Chan Kyo
authors.initials: CK
authors.lastname: Kim
authors.affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Byung Kwan
authors.initials: BK
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D059248:Chemoradiotherapy / Q000379:methods; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D018450:Disease Progression; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Cervical cancer; Concurrent chemoradiotherapy; Diffusion-weighted imaging; Disease progression; PET/CT