title: Pregnancy outcomes following the use of thiocolchicoside.
abstract: Thiocolchicoside is a commonly used muscle relaxant in orthopedic, rheumatologic or musculoskeletal disorders to treat painful muscle spasms. It is contraindicated in pregnancy and lactation. There is no previously published experience with thiocolchicoside exposure during pregnancy. In this observational study, we collected and evaluated 18 pregnancy outcomes of the women referred to our prenatal consultation service for thiocolchicoside exposure between 2007-2012, and offspring were followed up until 2 years of age. There were 16 live births, 1 spontaneous abortion and 1 elective termination of pregnancy. No major birth defect was observed. The mothers and their babies were free of perinatal complications. No growth or developmental abnormalities were found during follow-up period. Our findings add information on inadvertent use of thiocolchicoside in pregnancy. Further large prospective cohort studies are required to investigate this issue.
authors.affiliation: Department of Clinical Pharmacology and Toxicology, Izmir Ataturk Research Hospital, Izmir, Turkey. Electronic address: dr.zeyneb@hotmail.com.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ozturk
authors.affiliation: Department of Medical Pharmacology, Celal Bayar University, Manisa, Turkey.
authors.forename: Ercument
authors.initials: E
authors.lastname: Olmez
authors.affiliation: Department of Medical Pharmacology, Celal Bayar University, Manisa, Turkey.
authors.forename: Tugba
authors.initials: T
authors.lastname: Gurpinar
authors.affiliation: Department of Medical Pharmacology, Celal Bayar University, Manisa, Turkey.
authors.forename: Kamil
authors.initials: K
authors.lastname: Vural
mesh_terms: D000328:Adult; D003078:Colchicine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D009465:Neuromuscular Agents; D003078:Colchicine; C004280:thiocolchicoside
keywords: Contraindications; Fetus; Newborn; Pregnancy; Thiocolchicoside