title: Pharmacological agents used for treatment and prevention in noise-induced hearing loss.
abstract: Noise is a stress factor that causes auditory, psychological and physiological effects. The realization that sudden loud noises or chronic exposure to noise in social and working environments can cause hearing loss has led to increased interest in noise-induced hearing loss (NIHL). The best means of preventing primary damage is protection against noise. Since this protection is not always possible for various reasons, the use of pharmacological agents to prevent or treat NIHL should also be considered. The purpose of this study is to discuss current pharmacological protection and treatment options in the light of the literature, since no such extensive reviews have been performed to date, including agents used for protection against and treatment of NIHL. We reviewed both animal and clinical studies, and these are discussed separately for ease of comprehension. For each agent, first animal studies, then clinical studies, if available, are discussed. We also performed a two-step search of the literature. In the first step, we searched the terms "noise induced hearing loss", "treatment" and "protection" in Pubmed. Based on the results obtained, we identified the agents used for the treatment of and protection against NIHL. In the second step, we searched the names of the agents identified in the first step, together with the term "noise induced hearing loss," and reviewed the results.
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Muhammed Sedat
authors.initials: MS
authors.lastname: Sakat
authors.affiliation: Palandoken State Hospital, Otolaryngology Clinics, Erzurum, Turkey. korhankilic@gmail.com.
authors.forename: Korhan
authors.identifier: http://orcid.org/0000-0001-6048-034X
authors.initials: K
authors.lastname: Kilic
authors.affiliation: Department of Otolaryngology, School of Medicine, University of Yildirim Beyazit, Ankara, Turkey.
authors.forename: Sami
authors.initials: S
authors.lastname: Bercin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D016291:Dizocilpine Maleate; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy* / Q000517:prevention & control*; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use; D008715:Methionine / Q000627:therapeutic use; D009414:Nerve Growth Factors / Q000627:therapeutic use; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D002121:Calcium Channel Blockers; D018691:Excitatory Amino Acid Antagonists; D005938:Glucocorticoids; D009414:Nerve Growth Factors; D014815:Vitamins; D014451:Ubiquinone; D016291:Dizocilpine Maleate; D008715:Methionine; C024989:coenzyme Q10; D008274:Magnesium; C030571:ubiquinone 9
keywords: Noise-induced hearing loss; Pharmacological agents; Treatment and prevention