title: Brain Network Organization and Social Executive Performance in Frontotemporal Dementia.
abstract: OBJECTIVE
  Behavioral variant frontotemporal dementia (bvFTD) is characterized by early atrophy in the frontotemporoinsular regions. These regions overlap with networks that are engaged in social cognition-executive functions, two hallmarks deficits of bvFTD. We examine (i) whether Network Centrality (a graph theory metric that measures how important a node is in a brain network) in the frontotemporoinsular network is disrupted in bvFTD, and (ii) the level of involvement of this network in social-executive performance.
  
  
  METHODS
  Patients with probable bvFTD, healthy controls, and frontoinsular stroke patients underwent functional MRI resting-state recordings and completed social-executive behavioral measures.
  
  
  RESULTS
  Relative to the controls and the stroke group, the bvFTD patients presented decreased Network Centrality. In addition, this measure was associated with social cognition and executive functions. To test the specificity of these results for the Network Centrality of the frontotemporoinsular network, we assessed the main areas from six resting-state networks. No group differences or behavioral associations were found in these networks. Finally, Network Centrality and behavior distinguished bvFTD patients from the other groups with a high classification rate.
  
  
  CONCLUSIONS
  bvFTD selectively affects Network Centrality in the frontotemporoinsular network, which is associated with high-level social and executive profile.
authors.affiliation: 1Laboratory of Experimental Psychology and Neuroscience (LPEN),INECO (Institute of Cognitive Neurology) and Institute of Neuroscience,Favaloro University,Buenos Aires,Argentina.
authors.forename: Lucas
authors.initials: L
authors.lastname: Sedeño
authors.affiliation: 1Laboratory of Experimental Psychology and Neuroscience (LPEN),INECO (Institute of Cognitive Neurology) and Institute of Neuroscience,Favaloro University,Buenos Aires,Argentina.
authors.forename: Blas
authors.initials: B
authors.lastname: Couto
authors.affiliation: 1Laboratory of Experimental Psychology and Neuroscience (LPEN),INECO (Institute of Cognitive Neurology) and Institute of Neuroscience,Favaloro University,Buenos Aires,Argentina.
authors.forename: Indira
authors.initials: I
authors.lastname: García-Cordero
authors.affiliation: 1Laboratory of Experimental Psychology and Neuroscience (LPEN),INECO (Institute of Cognitive Neurology) and Institute of Neuroscience,Favaloro University,Buenos Aires,Argentina.
authors.forename: Margherita
authors.initials: M
authors.lastname: Melloni
authors.affiliation: 1Laboratory of Experimental Psychology and Neuroscience (LPEN),INECO (Institute of Cognitive Neurology) and Institute of Neuroscience,Favaloro University,Buenos Aires,Argentina.
authors.forename: Sandra
authors.initials: S
authors.lastname: Baez
authors.affiliation: 2UDP-INECO Foundation Core on Neuroscience (UIFCoN),Faculty of Psychology, Diego Portales University,Santiago,Chile.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Morales Sepúlveda
authors.affiliation: 3National Scientific and Technical Research Council (CONICET),Buenos Aires,Argentina.
authors.forename: Daniel
authors.initials: D
authors.lastname: Fraiman
authors.affiliation: 2UDP-INECO Foundation Core on Neuroscience (UIFCoN),Faculty of Psychology, Diego Portales University,Santiago,Chile.
authors.forename: David
authors.initials: D
authors.lastname: Huepe
authors.affiliation: 2UDP-INECO Foundation Core on Neuroscience (UIFCoN),Faculty of Psychology, Diego Portales University,Santiago,Chile.
authors.forename: Esteban
authors.initials: E
authors.lastname: Hurtado
authors.affiliation: 6Intellectus Memory and Cognition Center,Mental Health and Psychiatry Department,San Ignacio Hospital,Aging Institute,Pontifical Javeriana University,Bogotá,Colombia.
authors.forename: Diana
authors.initials: D
authors.lastname: Matallana
authors.affiliation: 2UDP-INECO Foundation Core on Neuroscience (UIFCoN),Faculty of Psychology, Diego Portales University,Santiago,Chile.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Kuljis
authors.affiliation: 1Laboratory of Experimental Psychology and Neuroscience (LPEN),INECO (Institute of Cognitive Neurology) and Institute of Neuroscience,Favaloro University,Buenos Aires,Argentina.
authors.forename: Teresa
authors.initials: T
authors.lastname: Torralva
authors.affiliation: 3National Scientific and Technical Research Council (CONICET),Buenos Aires,Argentina.
authors.forename: Dante
authors.initials: D
authors.lastname: Chialvo
authors.affiliation: 8Universidad Torcuato Di Tella,Buenos Aires,Argentina.
authors.forename: Mariano
authors.initials: M
authors.lastname: Sigman
authors.affiliation: 9Neuroscience Research Australia,Sydney, Australia and School of Medical Sciences,The University of New South Wales,Sydney,Australia.
authors.forename: Olivier
authors.initials: O
authors.lastname: Piguet
authors.affiliation: 1Laboratory of Experimental Psychology and Neuroscience (LPEN),INECO (Institute of Cognitive Neurology) and Institute of Neuroscience,Favaloro University,Buenos Aires,Argentina.
authors.forename: Facundo
authors.initials: F
authors.lastname: Manes
authors.affiliation: 1Laboratory of Experimental Psychology and Neuroscience (LPEN),INECO (Institute of Cognitive Neurology) and Institute of Neuroscience,Favaloro University,Buenos Aires,Argentina.
authors.forename: Agustin
authors.initials: A
authors.lastname: Ibanez
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001921:Brain / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology*; D004644:Emotions; D005260:Female; D057180:Frontotemporal Dementia / Q000150:complications / Q000000981:diagnostic imaging / Q000523:psychology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000187:drug effects*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012919:Social Behavior; D013223:Statistics as Topic; D020521:Stroke / Q000150:complications / Q000000981:diagnostic imaging / Q000523:psychology
chemical_list: D010100:Oxygen
keywords: Frontoinsular stroke; Functional connectivity; Graph theory analysis; Neurodegenerative disease; Node centrality; fMRI resting-state