title: Comparison between myocardial infarction and diabetes mellitus damage caused angiogenesis or energy metabolism.
abstract: This study aims to compare and analyze lactate dehydrogenase (LDH), succinic dehydrogenase (SDH) and differences in capillary density level in the model of myocardial damage which caused by rats diabetes. The Wistar rats were divided into 4 groups, including control, diabetic, myocardial infarction and two diseases combined group. Ligate descending branch of left coronary artery on 1/3 position or inject streptozotocin into abdominal cavity to establish two kinds of disease models. After 6 w, obtain the myocardial tissues to do the vascular density analysis of tissue sections which are stained and cell tissue enzyme. Explore change of relevant index and differences among groups. Results indicated that degree of LDH and SDH decrease in two kinds of disease model. Compared with control group, level of myocardial vascular of myocardial injury group is higher, and diabetic group is higher than non diabetic group. Quantitative result of FFA in mitochondrial suspension of single disease group is higher than that of control group and two diseases combined group. Level of FFA and LDH of two diseases combined group is consistent with control group. In conclusion, after myocardial damage, which is caused by diabetes mellitus or myocardial infarction, degree of local vascularization increases, diabetes mellitus is more obvious. After myocardial damage, process of myocardial mitochondrial glycolysis and oxidative phosphorylation has some obstacles. But these two kinds of diseases all have cardiac muscle cell which can keep generated procedure of aerobic and anaerobic energy to instead the normal function of cardiac muscle.
authors.affiliation: Department of Cardiology, Tianjin First Central Hospital Tianjin 300382, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Cardiology, Tianjin First Central Hospital Tianjin 300382, China.
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Lu
authors.affiliation: Department of Cardiology, Tianjin First Central Hospital Tianjin 300382, China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Tianjin First Central Hospital Tianjin 300382, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
keywords: Myocardial infarction; comparative analysis; diabetes mellitus; energy metabolism; myocardial damage; revascularization