title: Tip110: Physical properties, primary structure, and biological functions.
abstract: HIV-1 Tat-interacting protein of 110kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110(nrb), was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.
authors.affiliation: Department of Cell Biology and Immunology, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, United States.
authors.forename: Amanda
authors.initials: A
authors.lastname: Whitmill
authors.affiliation: Department of Cell Biology and Immunology, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, United States.
authors.forename: Khalid Amine
authors.initials: KA
authors.lastname: Timani
authors.affiliation: Department of Cell Biology and Immunology, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, United States.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cell Biology and Immunology, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, United States. Electronic address: johnny.he@unthsc.edu.
authors.forename: Johnny J
authors.initials: JJ
authors.lastname: He
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000951:Antigens, Neoplasm / Q000737:chemistry* / Q000502:physiology*; D017209:Apoptosis / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D009474:Neurons / Q000502:physiology; D012326:RNA Splicing / Q000502:physiology; D012333:RNA, Messenger / Q000502:physiology; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000502:physiology*
chemical_list: D000951:Antigens, Neoplasm; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C416530:SART3 protein, human
keywords: Development; Gene transcription; HIV replication; Post-translational modifications; Pre-mRNA splicing; Stem cell biology; Tip110