title: Sepsis following cancer surgery: the need for early recognition and standardised clinical care.
abstract: Despite the implementation of multimodal bundles of care in hospitalised patients, post-operative sepsis in patients with cancer still accounts for a significant burden of illness and substantial healthcare costs. Patients undergoing surgery for cancer are at particular risk of sepsis due to underlying malignancy, being immunocompromised associated with cancer management and the complexity of surgical procedures performed. In this review, we evaluate the burden of illness and risks for sepsis following surgery for cancer. Current evidence supporting standardised strategies for sepsis management (including early recognition and resuscitation) is examined together with challenges in implementing quality improvement programs.
authors.affiliation: a Department of Infectious Diseases and Infection Prevention , Peter MacCallum Cancer Centre , Melbourne , Victoria , Australia.
authors.forename: A
authors.initials: A
authors.lastname: Hiong
authors.affiliation: a Department of Infectious Diseases and Infection Prevention , Peter MacCallum Cancer Centre , Melbourne , Victoria , Australia.|b Department of Medicine , University of Melbourne , Melbourne , Victoria , Australia.|d National Centre for Antimicrobial Stewardship , Royal Melbourne Hospital at the Doherty Institute , Melbourne , Victoria , Australia.
authors.forename: K A
authors.initials: KA
authors.lastname: Thursky
authors.affiliation: a Department of Infectious Diseases and Infection Prevention , Peter MacCallum Cancer Centre , Melbourne , Victoria , Australia.
authors.forename: B W
authors.initials: BW
authors.lastname: Teh
authors.affiliation: a Department of Infectious Diseases and Infection Prevention , Peter MacCallum Cancer Centre , Melbourne , Victoria , Australia.
authors.forename: G M
authors.initials: GM
authors.lastname: Haeusler
authors.affiliation: a Department of Infectious Diseases and Infection Prevention , Peter MacCallum Cancer Centre , Melbourne , Victoria , Australia.|b Department of Medicine , University of Melbourne , Melbourne , Victoria , Australia.|d National Centre for Antimicrobial Stewardship , Royal Melbourne Hospital at the Doherty Institute , Melbourne , Victoria , Australia.
authors.forename: M A
authors.initials: MA
authors.lastname: Slavin
authors.affiliation: a Department of Infectious Diseases and Infection Prevention , Peter MacCallum Cancer Centre , Melbourne , Victoria , Australia.|b Department of Medicine , University of Melbourne , Melbourne , Victoria , Australia.|c Victorian Healthcare Associated Infection Surveillance System (VICNISS) Coordinating Centre , Melbourne , Victoria , Australia.
authors.forename: L J
authors.initials: LJ
authors.lastname: Worth
mesh_terms: D006801:Humans; D016867:Immunocompromised Host; D009369:Neoplasms / Q000601:surgery*; D011183:Postoperative Complications; D012307:Risk Factors; D018805:Sepsis / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy
keywords: Sepsis; cancer; surgery; surgical site infection; systemic inflammatory response syndrome (SIRS)