title: Cryoablation in fibro-adipose vascular anomaly (FAVA): a minimally invasive treatment option.
abstract: BACKGROUND
  Fibro-adipose vascular anomaly (FAVA) is a complex vascular malformation that typically presents with persistent pain, discomfort, contracture and other disabling symptoms. There are no minimally invasive treatment options to effectively control these symptoms. Image-guided percutaneous cryoablation, which has been used to control pain in people with cancer, could be used for similar indications in FAVA.
  
  
  OBJECTIVE
  To assess the role of image-guided percutaneous cryoablation for control of symptoms in FAVA lesions.
  
  
  METHODS
  We conducted a retrospective cohort study of 20 children and young adults with FAVA who underwent percutaneous cryoablation at 26 sites, from September 2013 to August 2015. The outcome was based on the brief pain inventory scoring (BPI), concurrent symptoms, clinical response and patient satisfaction.
  
  
  RESULTS
  After cryoablation there was significant improvement in pain, which dropped by 3 points (pain now) to 3.7 points (pain in the last 24 h). Most patients indicated that pain interfered less in their everyday social life. Concurrent symptoms like swelling, physical limitations and skin hyperesthesia also improved. Clinical response was greatest at 2-5 months follow-up after cryoablation, with acceptable patient satisfaction thereafter. Technical response was 100%. There were no major complications.
  
  
  CONCLUSIONS
  Image-guided percutaneous cryoablation is a safe and effective option for treatment of symptomatic FAVA lesions.
authors.affiliation: Department of Radiology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA. Raja.Shaikh@childrens.harvard.edu.
authors.forename: Raja
authors.initials: R
authors.lastname: Shaikh
authors.affiliation: Department of Radiology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.
authors.forename: Ahmad I
authors.initials: AI
authors.lastname: Alomari
authors.affiliation: Department of Radiology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Kerr
authors.affiliation: Department of Orthopedics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Miller
authors.affiliation: Department of Orthopedics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Samantha A
authors.initials: SA
authors.lastname: Spencer
mesh_terms: D000273:Adipose Tissue / Q000601:surgery; D000293:Adolescent; D015331:Cohort Studies; D003452:Cryosurgery; D003952:Diagnostic Imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010146:Pain / Q000209:etiology; D015641:Radiography, Interventional; D012189:Retrospective Studies; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional; D054079:Vascular Malformations / Q000150:complications / Q000601:surgery*
keywords: Adolescents; Children; Cryoablation; Fibro-adipose vascular anomaly; Interventional radiology