title: Detection of base-pair mismatches in DNA using graphene-based nanopore device.
abstract: We present a unique way to detect base-pair mismatches in DNA, leading to a different epigenetic disorder by the method of nanopore sequencing. Based on a tight-binding formulation of a graphene-based nanopore device, using the Green's function approach we study the changes in the electronic transport properties of the device as we translocate a double-stranded DNA through the nanopore embedded in a zigzag graphene nanoribbon. In the present work we are not only successful in detecting the usual AT and GC pairs but also a set of possible mismatches in the complementary base pairing.
authors.affiliation: Condensed Matter Physics Division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Kolkata 700 064, India.
authors.forename: Sourav
authors.initials: S
authors.lastname: Kundu
authors.forename: S N
authors.initials: SN
authors.lastname: Karmakar
mesh_terms: D000465:Algorithms; D020137:Base Pair Mismatch; D020029:Base Pairing; D004247:DNA / Q000032:analysis; D044127:Epigenesis, Genetic; D006108:Graphite / Q000737:chemistry*; D058608:Nanopores; D017422:Sequence Analysis, DNA / Q000295:instrumentation*
chemical_list: D006108:Graphite; D004247:DNA