title: Scaling up of renewable chemicals.
abstract: The transition of promising technologies for production of renewable chemicals from a laboratory scale to commercial scale is often difficult and expensive. As a result the timeframe estimated for commercialization is typically underestimated resulting in much slower penetration of these promising new methods and products into the chemical industries. The theme of 'sugar is the next oil' connects biological, chemical, and thermochemical conversions of renewable feedstocks to products that are drop-in replacements for petroleum derived chemicals or are new to market chemicals/materials. The latter typically offer a functionality advantage and can command higher prices that result in less severe scale-up challenges. However, for drop-in replacements, price is of paramount importance and competitive capital and operating expenditures are a prerequisite for success. Hence, scale-up of relevant technologies must be interfaced with effective and efficient management of both cell and steel factories. Details involved in all aspects of manufacturing, such as utilities, sterility, product recovery and purification, regulatory requirements, and emissions must be managed successfully.
authors.affiliation: DuPont Industrial Biosciences, 925 Page Mill Road, Palo Alto, CA 94304, USA. Electronic address: karl.sanford@dupont.com.
authors.forename: Karl
authors.initials: K
authors.lastname: Sanford
authors.affiliation: DuPont Industrial Biosciences, 925 Page Mill Road, Palo Alto, CA 94304, USA.
authors.forename: Gopal
authors.initials: G
authors.lastname: Chotani
authors.affiliation: DuPont Industrial Biosciences, 925 Page Mill Road, Palo Alto, CA 94304, USA.
authors.forename: Nathan
authors.initials: N
authors.lastname: Danielson
authors.affiliation: DuPont Industrial Biosciences, 198 Blair Bend Drive, Loudon, TN 37774, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: Zahn
mesh_terms: D000818:Animals; D055162:Biocatalysis; D001709:Biotechnology / Q000379:methods; D002617:Chemical Industry / Q000379:methods*; D006801:Humans; D059027:Recycling