title: Risk of hospitalization due to pneumococcal disease in adults in Spain. The CORIENNE study.
abstract: Pneumococcal disease causes a high burden of disease in adults, leading to high rates of hospitalization, especially in the elderly. All hospital discharges for pneumococcal disease and pneumococcal pneumonia among adults over 18 y of age reported in first diagnostic position in 2011 (January 1, 2011 through December 31, 2011) were obtained. A total of 10,861 hospital discharges due to pneumococcal disease were reported in adults in Spain in 2011 with an annual incidence of hospitalization of 0.285 (CI 95%: 0.280-0.291) per 1,000 population over 18 y old. Case-fatality rate was 8%. Estimated cost of these hospitalisations in 2011 was more than 57 million €. Pneumococcal pneumonia accounted for the 92% of the hospital discharges All the chronic condition studied: asplenia, chronic respiratory disease, chronic heart disease, chronic renal disease, Diabetes Mellitus and immunosuppression, increased the risk of hospitalization in patients with pneumococcal pneumonia, especially in those aged 18-64 y old. Case-fatality rate among adult patients hospitalized with at least one underlying condition was significantly higher than among patients without comorbidities. Our results identified asplenia, chronic respiratory disease, chronic heart disease, chronic renal disease, chronic liver disease, Diabetes Mellitus and immunosuppression as risk groups for hospitalization. Older adults, immunocompromised patients and immunocompetent patients with underlying conditions could benefit from vaccination.
authors.affiliation: a Area of Preventive Medicine & Public Health, Rey Juan Carlos University , Madrid , Spain.
authors.forename: Ruth
authors.initials: R
authors.lastname: Gil-Prieto
authors.affiliation: a Area of Preventive Medicine & Public Health, Rey Juan Carlos University , Madrid , Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Pascual-Garcia
authors.affiliation: b Department of Epidemiology and Biostatistics , University of California , San Francisco, San Francisco , CA , USA.
authors.forename: Stefan
authors.initials: S
authors.lastname: Walter
authors.affiliation: a Area of Preventive Medicine & Public Health, Rey Juan Carlos University , Madrid , Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Álvaro-Meca
authors.affiliation: a Area of Preventive Medicine & Public Health, Rey Juan Carlos University , Madrid , Spain.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Gil-De-Miguel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D017048:Health Care Costs; D006760:Hospitalization / Q000191:economics*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D012189:Retrospective Studies; D018570:Risk Assessment; D013030:Spain; D016019:Survival Analysis; D055815:Young Adult
keywords: Spain; epidemiology; hospitalizations; pneumococcal disease; pneumococcal pneumonia