title: Copper-catalyzed intermolecular oxyamination of olefins using carboxylic acids and O-benzoylhydroxylamines.
abstract: This paper reports a novel approach for the direct and facile synthesis of 1,2-oxyamino moieties via an intermolecular copper-catalyzed oxyamination of olefins. This strategy utilizes O-benzoylhydroxylamines as an electrophilic amine source and carboxylic acids as a nucleophilic oxygen source to achieve a modular difunctionalization of olefins. The reaction proceeded in a regioselective manner with moderate to good yields, exhibiting a broad scope of carboxylic acid, amine, and olefin substrates.
authors.affiliation: Department of Chemistry, Duke University, Durham, NC, USA.
authors.forename: Brett N
authors.initials: BN
authors.lastname: Hemric
authors.affiliation: Department of Chemistry, Duke University, Durham, NC, USA.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Wang
keywords: copper; electrophilic amination; olefin oxyamination