title: Effects of NO Donors and Inhibitors of NO Synthase and Guanylate Cyclase on the Acquisition of a Conditioned Defense Food Aversion Response in Edible Snails.
abstract: Experiments on edible snails revealed that NO synthase blockade with a nonspecific neuronal NO synthase inhibitor L-NAME before defense food aversion conditioning is followed by a decrease in the rate of learning. Exogenous NO donors, sodium nitroprusside and dinitrosyl iron complex, were shown to improve learning. Chronic administration of a specific soluble guanylate cyclase inhibitor ODQ also increased the rate of learning. Our results indicate that NO has a modulatory effect on the formation of a conditioned response in this type of learning.
authors.affiliation: Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Muranova
authors.affiliation: Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: T Kh
authors.initials: TKh
authors.lastname: Bogodvid
authors.affiliation: Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Andrianov
authors.affiliation: Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Russia. kh_gainotdinov@mail.ru.
authors.forename: Kh L
authors.initials: KhL
authors.lastname: Gainutdinov
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors*; D007501:Iron / Q000737:chemistry; D007858:Learning / Q000187:drug effects*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D009569:Nitric Oxide / Q000737:chemistry*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D009589:Nitrogen Oxides / Q000737:chemistry; D009599:Nitroprusside / Q000737:chemistry; D010069:Oxadiazoles / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology; D012758:Shellfish; D012908:Snails
chemical_list: C494582:1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one; D004791:Enzyme Inhibitors; D009589:Nitrogen Oxides; D010069:Oxadiazoles; D011810:Quinoxalines; D009599:Nitroprusside; D009569:Nitric Oxide; C073661:dinitrosyl iron complex; D007501:Iron; D019001:Nitric Oxide Synthase; D006162:Guanylate Cyclase; D019331:NG-Nitroarginine Methyl Ester
keywords: L-NAME; dinitrosyl iron complex; food aversion; nitric oxide; sodium nitroprusside