title: Inefficient DMN Suppression in Schizophrenia Patients with Impaired Cognitive Function but not Patients with Preserved Cognitive Function.
abstract: Previous studies have observed reduced suppression of the default mode network (DMN) during cognitive tasks in schizophrenia, suggesting inefficient DMN suppression is critical for the cognitive deficits of schizophrenia. Cognitive function in schizophrenia patients, however, varies from relatively intact to severely impaired. This study, which compared the DMN suppression patterns between first-episode schizophrenia patients with (SZ-Imp) and without (SZ-Pre) impaired cognitive function, may provide further insight into the role of DMN dysfunction in cognitive deficits of schizophrenia. Independent component analysis (ICA) was applied to resting-state fMRI data to identify the DMN in each subject, and then general linear modeling based on the task-fMRI data was used to examine the different DMN activation patterns between groups. We observed that the SZ-Imp group, but not the SZ-Pre group, showed reduced suppression in the medial prefrontal cortex and posterior cingulated cortex when compared to the healthy controls (HC) group. Moreover, less DMN suppression was associated with poorer task performance in both HC and patient groups. Our findings provide the first direct evidence that disrupted DMN activity only exists in schizophrenia patients with impaired cognitive function, supporting the specific neuro-pathological role of inefficient DMN suppression in cognitive deficits of first-episode schizophrenia.
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.|The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.
authors.forename: Weidan
authors.initials: W
authors.lastname: Pu
authors.affiliation: Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Jingjuan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Mental Heath Centre, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Haihong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Wu
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|College of Health Sciences, University of Dodoma, P.O. Box 395, Dodoma, Tanzania.
authors.forename: Tumbwene E
authors.initials: TE
authors.lastname: Mwansisya
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.
authors.forename: Haojuan
authors.initials: H
authors.lastname: Tao
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Huang
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Lv
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Xue
authors.affiliation: Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, People's Republic of China.|Beijing Engineering Research Center of Radio-graphic Techniques and Equipment, Beijing, People's Republic of China.
authors.forename: Baoci
authors.initials: B
authors.lastname: Shan
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.|State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Zhening
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000473:pathology; D003072:Cognition Disorders / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging*; D017397:Prefrontal Cortex / Q000473:pathology; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology; D055815:Young Adult