title: Selective Aromatic C-H Hydroxylation Enabled byη6-Coordination to Iridium(III).
abstract: We report an aromatic C-H hydroxylation protocol in which the arene is activated throughη6-coordination to an iridium(III) complex.η6-Coordination of the arene increases its electrophilicity and allows for high positional selectivity of hydroxylation at the site of least electron density. Through investigation of intermediateη5-cyclohexadienyl adducts and arene exchange reactions, we evaluate incorporation of areneπ-activation into a catalytic cycle for C-H functionalization.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
authors.forename: Erica M
authors.initials: EM
authors.lastname: D'Amato
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
authors.forename: Constanze N
authors.initials: CN
authors.lastname: Neumann
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
authors.forename: Tobias
authors.initials: T
authors.lastname: Ritter