title: Costimulation Engages the Gear in Driving CARs.
abstract: In this issue of Immunity,Kawalekar et al. (2016) find that costimulation by a chimeric antigen receptor (CAR) can control T cell metabolism and balance the response toward long-lived memory or short-lived effector cells. The results provide a rationale of how to tune cancer immunotherapy more effectively in a hostile tumor environment.
authors.affiliation: Center for Molecular Medicine Cologne, University of Cologne, and Department I of Internal Medicine, University Hospital Cologne, Robert-Koch-Str. 21, 50931 Cologne, Germany. Electronic address: hinrich.abken@uk-koeln.de.
authors.forename: Hinrich
authors.initials: H
authors.lastname: Abken
mesh_terms: D018106:CD28 Antigens / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D019496:Cancer Vaccines / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000628:therapy*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9 / Q000378:metabolism*
chemical_list: D018106:CD28 Antigens; D019496:Cancer Vaccines; D011948:Receptors, Antigen, T-Cell; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9