title: Is yolk sac tumor related to the pathophysiology of low birthweight?
abstract: An 8-year-old Japanese girl was admitted with an ovarian yolk sac tumor. Regarding birth history, the patient had been delivered by cesarean section at 25 weeks of gestation with a birthweight of 711g. She had required neonatal intensive care including oxygenation, various medications, and tests. After surgery and chemotherapy, there was no recurrence for 2 years, at the time of writing. Yolk sac tumor, which is a malignant germ cell tumor, is rare in children. Although the cause and risk factors are unclear, it has been reported that malignant germ cell tumors in childhood have been associated with pathophysiology at birth. Given that premature infants are more likely to survive due to advances in perinatal care, it is expected that such cases will increase in the near future. We suggest that children born prematurely require careful follow up.
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kubo
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Shimono
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Fuke
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Okada
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwase
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kusaka
authors.affiliation: Department of Perinatology and Gynecology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Uiko
authors.initials: U
authors.lastname: Hanaoka
authors.affiliation: Department of Perinatology and Gynecology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kanenishi
authors.affiliation: Department of Perinatology and Gynecology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hata
authors.affiliation: Department of Pediatrics, Takamatsu Red Cross Hospital, Kagawa, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kozan
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Fujii
authors.affiliation: Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Katsuki
authors.affiliation: Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kushida
authors.affiliation: Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Reiji
authors.initials: R
authors.lastname: Haba
keywords: children; germ cell tumor; low birthweight; yolk sac tumor