title: Therapeutic effects of cytoprotective agent on breast reconstruction after breast cancer surgery.
abstract: Most patients will choose breast reconstruction after breast cancer surgery, while radiotherapy will damage skin and soft tissue so that will have adverse effect on reconstruction. In this study, we assume that the usage of Amifostine can reduce the incidence of complications after breast reconstruction so that provides more choices of reconstruction operation. Dividing SD rats into surgical placement expansion material group (include 15 ml normal saline) and simple operation group. Then further divide the former into non intervention group , radiation group and Radiation therapy combined with Amie amifostine treatment group. The decubation is 45 days after operation. Macroscopic evaluate the complications of skin and soft tissue by ImageJ. There is no obvious complications of skin and soft tissue for control group, radiotherapy alone group and radiotherapy with application of Amifostine group by macroscopic evaluation. The animals that are in expanded object group, damage probability of skin and soft tissue when use Amifostine is lower than that of radiotherapy alone group (30% vs. 69%, P=0.041). ImageJ shows the necrosis probability of skin and soft tissue when use Amifostine is obvious lower than radiotherapy alone group (6.96% vs. 12.94%, P=0.019). In conclusion, prevention and treatment of Amifostine can significantly reduce the complications of skin and soft tissue which is helpful to breast reconstruction after breast cancer surgery.
authors.affiliation: Department of Oncology, Affiliated Hospital of Qingdao University Qingdao 266001, China.
authors.forename: Xinjia
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Medical Imaging, Qingdao Women and Children's Hospital Qingdao 266003, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Oncology, Affiliated Hospital of Qingdao University Qingdao 266001, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Oncology, Affiliated Hospital of Qingdao University Qingdao 266001, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Breast Surgery Affiliated Hospital of Qingdao University Qingdao 266001, China.
authors.forename: Xingang
authors.initials: X
authors.lastname: Wang
keywords: Amifostine; Mammary cancer; breast reconstruction; cytoprotective agent