title: Termination of pregnancy after prenatal diagnosis of spina bifida: a German perspective.
abstract: To analyze fetal cases with spina bifida undergoing termination of pregnancy according to chromosomal analysis and further diagnosed sonographic findings.
  
  
  
  Retrospective analysis of cases with spina bifida leading to termination of pregnancy in a tertiary referral center from 2002 to 2011.
  
  
  
  In the study period, 246 cases of spina bifida were diagnosed in our center and 157 parents chose termination of pregnancy. The time of diagnosis was on average 2 days before the first presentation at our department (22 + 3, range: 12 + 3 - 33 + 3 weeks of gestation). Among 157 pregnancies with spina bifida and termination of pregnancy, further malformations could be detected in 46 (29.3 %) cases. An abnormal karyotype could be found in 13 (18.1 %). Severe ventriculomegaly or mild/moderate ventriculomegaly was present in 109 (69.4 %) and 29 (18.5 %) of the cases, respectively, while banana sign was detectable in 153 cases (97.5 %). In the majority, the upper lesion level was lumbar (71.3 %). In 67 cases (42.7 %), termination of pregnancy took place in or after the 24th week of gestation.
  
  
  
  Direct and indirect signs of spina bifida were detectable in nearly all cases independent of the gestational age. Therefore, the diagnosis could have been made in all cases with late termination. Implementation of a uniform prenatal care including first-trimester scan with potential signs for open spina bifida and second-trimester anomaly scan with indirect intracranial findings and direct detection of spinal lesion could lead to an earlier diagnosis and help to reduce late termination of pregnancy in neural tube defects.
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, 53105, Bonn, Germany. Christian.Domroese@ukb.uni-bonn.de.
authors.forename: Christian M
authors.identifier: 0000-0001-8084-8893
authors.initials: CM
authors.lastname: Domröse
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, 53105, Bonn, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Bremer
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, 53105, Bonn, Germany.
authors.forename: Caroline
authors.initials: C
authors.lastname: Buczek
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, 53105, Bonn, Germany.
authors.forename: Annegret
authors.initials: A
authors.lastname: Geipel
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, 53105, Bonn, Germany.|Department of Obstetrics and Gynecology, University of Cologne, 50931, Cologne, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Berg
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, 53105, Bonn, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Gembruch
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, 53105, Bonn, Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Willruth
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011295:Prenatal Care; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D016135:Spinal Dysraphism / Q000175:diagnosis*; D016216:Ultrasonography, Prenatal / Q000379:methods*; D055815:Young Adult
keywords: Neural tube defect; Spina bifida; Termination of pregnancy; Ultrasound