title: Neuroprotection by combination of resveratrol and enriched environment against ischemic brain injury in rats.
abstract: OBJECTIVE
  Both resveratrol (RV) and enriched environment (EE) exert beneficial effects on neurological functional recovery after an ischemic brain injury.
  
  
  METHODS
  The neuroprotective effect of combined treatment of RV and EE was examined in a rat model of middle cerebral artery occlusion (MCAO), aiming to further promote neurological functional recovery.
  
  
  RESULTS
  The combined therapy of RV and EE clearly improved locomotor activity and behaviour examination, compared to the monotherapy of RV or EE alone. Stroke severity was also markedly ameliorated by the co-treatment. Mechanistic study revealed that the combined treatment reduced oxidative stress. Moreover, the detrimental ERK1/2 signalling upregulated by MCAO injury was markedly suppressed by the co-treatment, compared to RV or EE monotherapy.
  
  
  CONCLUSIONS
  Altogether, the combined therapy of RV and EE showed a clearly enhanced neuroprotective effect, compared to RV or EE monotherapy, which might be a new strategy for the treatment of ischemic brain injury.
authors.affiliation: a Department of Rehabilitation Medicine , Nanjing Medical University Affiliated Wuxi Second Hospital , 68 Zhongshan Road, Wuxi 214002 , China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Su
authors.affiliation: b Department of Neurology , Nanjing Medical University Affiliated Wuxi Second Hospital , 68 Zhongshan Road, Wuxi 214002 , China.
authors.forename: Huaifang
authors.initials: H
authors.lastname: Pu
authors.affiliation: c Department of Pediatrics , Nanjing Medical University Affiliated Wuxi Second Hospital , 68 Zhongshan Road, Wuxi 214002 , China.
authors.forename: Cailian
authors.initials: C
authors.lastname: Hu
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001929:Brain Edema / Q000209:etiology; D020520:Brain Infarction / Q000188:drug therapy / Q000209:etiology / Q000451:nursing; D001930:Brain Injuries / Q000188:drug therapy / Q000209:etiology / Q000451:nursing; D004195:Disease Models, Animal; D004777:Environment; D006861:Hydrogen Peroxide / Q000378:metabolism; D020244:Infarction, Middle Cerebral Artery / Q000150:complications*; D008124:Locomotion / Q000187:drug effects; D020935:MAP Kinase Signaling System / Q000187:drug effects; D008297:Male; D009460:Neurologic Examination; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
chemical_list: D018696:Neuroprotective Agents; D013267:Stilbenes; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; D000077185:Resveratrol
keywords: Brain injury; Enriched environment; Ischemia; Neuroprotection; Resveratrol