title: Diffusion-weighted multiparametric MRI for monitoring longitudinal changes of parameters in rabbit VX2 liver tumors.
abstract: To investigate the value of different quantitative models of diffusion-weighted multiparametric imaging (DW-MPI) including traditional as well as several advanced models for monitoring the longitudinal parameter changes in rabbit liver VX2 carcinoma and for correlating the perfusion-related imaging parameters to vascularity of tumor tissue.
  
  
  
  Rabbit liver VX2 carcinoma was imaged by DW-MPI at the 2nd, 3rd, and 4th weeks after tumor implantation at 1.5T using two sets of b values ranging from 0 to 2000 s/mm(2) . Serial parameter changes of each model at three timepoints were compared. Univariate and multivariate regression analyses were carried out to analyze the ability of perfusion-related parameters, including apparent diffusion coefficient (ADC), perfusion fraction (f), and pseudodiffusion coefficient (D*), to predict mean microvessel density (MVD) as determined by quantitative histopathology.
  
  
  
  For the period from Week 2 to Week 4, the measurements of ADC, f, and KDKI illustrated a statistical difference (P = 0.000, P = 0.000, and P = 0.002, respectively), whereas the comparison of D, D*, DDKI , DSEM , and αSEM demonstrated no statistical significance. ADC and f showed highest correlation with MVD at Week 4 (r(2)  = 0.307, P = 0.017, and r(2)  = 0.402, P < 0.01, respectively). Multivariate analyses confirmed highest correlation of f and ADC with MVD at Week 4 (P = 0.001 and P = 0.002).
  
  
  
  ADC, f, and KDKI were identified as the most promising parameters for monitoring changes in rabbit liver VX2 carcinoma and f and ADC showed highest correlation with MVD. J. Magn. Reson. Imaging 2016;44:707-714.
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China.|Graduate College, Southern Medical University, Guangzhou, Guangdong Province, PR China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China.
authors.forename: Changhong
authors.initials: C
authors.lastname: Liang
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China.
authors.forename: Shuixing
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China.
authors.forename: Zaiyi
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China.
authors.forename: Chunling
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China.
authors.forename: Yubao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China.|Graduate College, Southern Medical University, Guangzhou, Guangdong Province, PR China.
authors.forename: Maoqing
authors.initials: M
authors.lastname: Hu
authors.affiliation: Graduate College, Southern Medical University, Guangzhou, Guangdong Province, PR China.
authors.forename: Chuanzi
authors.initials: C
authors.lastname: Li
authors.affiliation: Philips Healthcare, Guangzhou, PR China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Mei
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D045744:Cell Line, Tumor; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D008137:Longitudinal Studies; D008297:Male; D064847:Multimodal Imaging / Q000379:methods*; D011817:Rabbits; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
keywords: apparent diffusion coefficient; diffusion-weighted MRI; liver carcinoma