title: Pancreatitis in hand-foot-and-mouth disease caused by enterovirus 71.
abstract: Some viruses, including certain members of the enterovirus genus, have been reported to cause pancreatitis, especially Coxsackie virus. However, no case of human enterovirus 71 (EV71) associated with pancreatitis has been reported so far. We here report a case of EV71-induced hand-foot-and-mouth disease (HFMD) presenting with pancreatitis in a 2-year-old girl. This is the first report of a patient with acute pancreatitis in HFMD caused by EV71. We treated the patient conservatively with nasogastric suction, intravenous fluid and antivirals. The patient's symptoms improved after 8 d, and recovered without complications. We conclude that EV71 can cause acute pancreatitis in HFMD, which should be considered in differential diagnosis, especially in cases of idiopathic pancreatitis.
authors.affiliation: Yu-Feng Zhang, Hui-Ling Deng, Jia Fu, Yu Zhang, Department Second of Infectious Diseases, Xi'an Children's Hospital, Xi'an 710003, Shaanxi Province, China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zhang
authors.affiliation: Yu-Feng Zhang, Hui-Ling Deng, Jia Fu, Yu Zhang, Department Second of Infectious Diseases, Xi'an Children's Hospital, Xi'an 710003, Shaanxi Province, China.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Deng
authors.affiliation: Yu-Feng Zhang, Hui-Ling Deng, Jia Fu, Yu Zhang, Department Second of Infectious Diseases, Xi'an Children's Hospital, Xi'an 710003, Shaanxi Province, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Fu
authors.affiliation: Yu-Feng Zhang, Hui-Ling Deng, Jia Fu, Yu Zhang, Department Second of Infectious Diseases, Xi'an Children's Hospital, Xi'an 710003, Shaanxi Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Yu-Feng Zhang, Hui-Ling Deng, Jia Fu, Yu Zhang, Department Second of Infectious Diseases, Xi'an Children's Hospital, Xi'an 710003, Shaanxi Province, China.
authors.forename: Jian-Qiang
authors.initials: JQ
authors.lastname: Wei
mesh_terms: D000208:Acute Disease; D000998:Antiviral Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004322:Drainage / Q000379:methods; D029821:Enterovirus A, Human / Q000302:isolation & purification*; D005260:Female; D005440:Fluid Therapy; D006232:Hand, Foot and Mouth Disease / Q000150:complications / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D006801:Humans; D007441:Intubation, Gastrointestinal; D010195:Pancreatitis / Q000000981:diagnostic imaging / Q000628:therapy / Q000821:virology*; D012074:Remission Induction; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents
keywords: Enterovirus 71; Hand, foot and mouth disease; Pancreatitis