title: A new anti-proliferative acylated flavonol glycoside from Fuzhuan brick-tea.
abstract: Fuzhuan brick-tea (FBT) is unique for a fungal fermentation stage in its manufacture process and is classified in dark tea. A new acylated flavonol glycoside, kaempferol 3-O-[E-p-coumaroyl-(→2)][α-l-arabinopyranosyl-(1→3)][α-l-rhamnopyranosyl(1→6)]-β-d-glucopyranoside, which was trivially named as camellikaempferoside A (1), was isolated from FBT along with camelliquercetiside C (2). Their structures were unambiguously elucidated by combination of spectroscopic and chemical methods. Compound 1 showed anti-proliferative activity against MCF-7 and MDA-MB-231 cells with IC50values of 7.83 and 19.16 μM, respectively.
authors.affiliation: a State Key Laboratory of Tea Plant Biology and Utilization , Anhui Agricultural University , Hefei , P.R. China.
authors.forename: Yong-Zhen
authors.initials: YZ
authors.lastname: Tian
authors.affiliation: a State Key Laboratory of Tea Plant Biology and Utilization , Anhui Agricultural University , Hefei , P.R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: b School of Life Sciences , Anhui Agricultural University , Hefei , P.R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
authors.affiliation: b School of Life Sciences , Anhui Agricultural University , Hefei , P.R. China.
authors.forename: Wei-Yun
authors.initials: WY
authors.lastname: Wang
authors.affiliation: b School of Life Sciences , Anhui Agricultural University , Hefei , P.R. China.
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Long
authors.affiliation: a State Key Laboratory of Tea Plant Biology and Utilization , Anhui Agricultural University , Hefei , P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a State Key Laboratory of Tea Plant Biology and Utilization , Anhui Agricultural University , Hefei , P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: a State Key Laboratory of Tea Plant Biology and Utilization , Anhui Agricultural University , Hefei , P.R. China.
authors.forename: Guan-Hu
authors.initials: GH
authors.lastname: Bao
authors.affiliation: a State Key Laboratory of Tea Plant Biology and Utilization , Anhui Agricultural University , Hefei , P.R. China.
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Wan
authors.affiliation: a State Key Laboratory of Tea Plant Biology and Utilization , Anhui Agricultural University , Hefei , P.R. China.
authors.forename: Tie-Jun
authors.initials: TJ
authors.lastname: Ling
keywords: Fuzhuan brick-tea; MCF-7 cells; MDA–MB-231 cells; anti-proliferative activity; camellikaempferoside A; dark tea