title: Schizophrenia as a prodromal symptom in a patient harboring SNCA duplication.
abstract: We present the case of a patient who developed delusions and auditory hallucinations and was clinically diagnosed as having schizophrenia. Ten years after the onset of schizophrenia, the disease progressed to mild parkinsonism. SNCA duplication was confirmed. This case expands the spectrum of clinical features in carriers of SNCA duplication.
authors.affiliation: Department of Neuropsychiatry, Kochi Medical School Hospital, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi-ken 783-8505, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Takamura
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Ikeda
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Kenya
authors.initials: K
authors.lastname: Nishioka
authors.affiliation: Department of Neurology, Kochi Medical School Hospital, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi-ken 783-8505, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Furuya
authors.affiliation: Department of Clinical Genetics, Kochi Medical School Hospital, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi-ken 783-8505, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Tashiro
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsushima
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Yuanzhe
authors.initials: Y
authors.lastname: Li
authors.affiliation: Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Hiroyo
authors.initials: H
authors.lastname: Yoshino
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Funayama
authors.affiliation: Department of Neuropsychiatry, Kochi Medical School Hospital, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi-ken 783-8505, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Morinobu
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address: nhattori@juntendo.ac.jp.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000235:genetics* / Q000523:psychology; D010375:Pedigree; D062706:Prodromal Symptoms; D012559:Schizophrenia / Q000235:genetics*; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: C497604:SNCA protein, human; D051844:alpha-Synuclein
keywords: Dementia with Lewy bodies; Parkinson's disease; Psychosis; SNCA duplication; Schizophrenia