title: Prevalence of Airflow Limitation Defined by Pre- and Post-Bronchodilator Spirometry in a Community-Based Health Checkup: The Hisayama Study.
abstract: Spirometry in health checkup may contribute to early diagnosis of chronic obstructive pulmonary disease (COPD) and asthma. Although post-bronchodilator airflow limitation is essential for definite diagnosis of COPD and post-bronchodilator normalization of airflow is suggestive of asthma, this test has not been prevailed in health checkup. The objective of this study was to estimate the prevalence of airflow limitation defined by pre- and post-bronchodilator spirometry in health checkup. Post-bronchodilator spirometry was conducted for participants with airflow limitation in a town-wide health checkup for residents aged 40 years and older in Hisayama, a town in the western part of Japan. The prevalence of pre- and post-bronchodilator airway limitation defined by FEV1/FVC < 70% were estimated. A total of 2,232 participants underwent pre-bronchodilator spirometry. In males, the age of current smokers was significantly younger than those of never smokers and former smokers. In females, the ages of current- and former smokers were significantly younger than never smokers. The values of %FEV1 and %FVC in current smokers were significantly lower than those in former smokers and never smokers. Two hundred sixty nine subjects, 85% of total subjects with a pre-bronchodilator FEV1/FVC < 70%, completed post-bronchodilator spirometry. The prevalence of pre-bronchodilator airflow limitation was 14.6% in males and 13.7% in females, and the prevalence of post-bronchodilator airway limitation was 8.7% and 8.7%, respectively. Post-bronchodilator spirometry in health checkup would reduce the number of subjects with probable COPD to two-third. Recommendation for those examinees to take further evaluations may pave the way for early intervention.
authors.affiliation: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Satoru
authors.initials: S
authors.lastname: Fukuyama
authors.forename: Koichiro
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Keiko
authors.initials: K
authors.lastname: Kan-o
authors.forename: Naotaka
authors.initials: N
authors.lastname: Noda
authors.forename: Yukari
authors.initials: Y
authors.lastname: Tajiri-Asai
authors.forename: Takako
authors.initials: T
authors.lastname: Nakano
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Ishii
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kiyohara
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Inoue
mesh_terms: D000368:Aged; D001993:Bronchodilator Agents / Q000494:pharmacology*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006262:Health; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012123:Pulmonary Ventilation / Q000187:drug effects*; D012111:Residence Characteristics; D013147:Spirometry
chemical_list: D001993:Bronchodilator Agents