title: Variability of the Phenotype and Proliferation and Migration Characteristics of Human Mesenchymal Stromal Cells Derived from the Deciduous Teeth Pulp of Different Donors.
abstract: We performed a comparative study of cell phenotype and proliferation and migration activities in vitro of mesenchymal stromal cells from human exfoliated deciduous teeth (SHED cells) from three donors. In the primary cultures, the cells of different donors had the same morphology and cytophenotype, but differed by proliferative and migration capacities. The results indicate that individual mesenchymal stromal cells cultures can differ considerably by important cell properties, and this should be considered when evaluating their potential therapeutic efficacy and in experimental studies.
authors.affiliation: V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia. vakhrunya@gmail.com.
authors.forename: I V
authors.initials: IV
authors.lastname: Vakhrushev
authors.affiliation: V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Vdovin
authors.affiliation: Qvadros-Bio Company, Moscow, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Strukova
authors.affiliation: V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: K N
authors.initials: KN
authors.lastname: Yarygin
mesh_terms: D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation / Q000502:physiology*; D064987:Cell- and Tissue-Based Therapy; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D003782:Dental Pulp / Q000166:cytology*; D005260:Female; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010641:Phenotype; D014094:Tooth, Deciduous / Q000166:cytology*
keywords: SHED cells; dental pulp; mesenchymal stromal cells; tissue engineering