title: 4E-BP1, a multifactor regulated multifunctional protein.
abstract: Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway. Phosphorylation of 4E-BP1 causes its release from eIF4E to allow cap-dependent translation to proceed. Recently, 4E-BP1 was shown to be phosphorylated by other kinases besides mTOR, and overexpression of 4E-BP1 was found in different human carcinomas. In this review, we summarize the novel findings on mTOR independent 4E-BP1 phosphorylation in carcinomas. The implications of overexpression and possible multi-function of 4E-BP1 are also discussed.
authors.affiliation: a Department of Oncology , Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Qin
authors.affiliation: a Department of Oncology , Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
authors.forename: Bin
authors.initials: B
authors.lastname: Jiang
authors.affiliation: a Department of Oncology , Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000378:metabolism; D018797:Cell Cycle Proteins; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / Q000235:genetics / Q000378:metabolism; D000076222:Mechanistic Target of Rapamycin Complex 1; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics* / Q000378:metabolism; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010442:Peptide Chain Initiation, Translational; D010750:Phosphoproteins / Q000235:genetics* / Q000378:metabolism; D010766:Phosphorylation; D000076223:Regulatory-Associated Protein of mTOR; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; C087000:EIF4EBP1 protein, human; D046912:Multiprotein Complexes; D010750:Phosphoproteins; C463659:RPTOR protein, human; D000076223:Regulatory-Associated Protein of mTOR; C546842:MTOR protein, human; C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases; D020928:Mitogen-Activated Protein Kinases
keywords: cancer; eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1; kinase; mTOR; overexpression; phosphorylation