title: Clinical significance of urothelial carcinoma associated 1 in colon cancer.
abstract: This study aimed to investigate the expression levels of urothelial carcinoma associated 1 (UCA1) in cancer tissues and plasma of colon cancer patients, and evaluate its clinical significance. Quantitative real-time PCR was used to determine the expression levels of UCA1 in 80 pairs of colon cancer and adjacent normal tissues, plasma samples from 20 healthy controls, 20 colon cancer patients before and after tumor removal. The relationships between UCA1 expression and clinical features and overall survival were analyzed. Compared with adjacent normal tissues, UCA1 was significantly upregulated in colon cancer tissues, especially in cases with LNM and advanced TNM stages (P < 0.05). High UCA1 expression was associated with LMN, higher pT category, and advanced TNM stages (P < 0.05). Patients with high UCA1 expression had worse survival time than those with low UCA1 expression (adjusted HR = 2.002, 95% CI 1.007-3.981, P = 0.048). Furthermore, plasma levels of UCA1 in colon cancer patients were significantly higher than those of controls (P = 0.016). There was significant difference in plasma level of UCA1 between samples taken before and after surgery (P = 0.048). In conclusion, tissue expression of UCA1 is related to prognosis in colon cancer. Plasma UCA1 may serve as a potential biomarker for early diagnosis and disease monitoring of colon cancer patients.
authors.affiliation: Department of Pathology, Tongren Hospital, Shanghai Jiao Tong University School of MedicineShanghai 200336, China; Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical UniversityShanghai 200433, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Tao
authors.affiliation: Department of Pathology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200336, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Pathology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200336, China.
authors.forename: Yuemei
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Pathology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200336, China.
authors.forename: Yaohua
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Pathology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200336, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Tan
authors.affiliation: Department of Pathology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200336, China.
authors.forename: Jinglin
authors.initials: J
authors.lastname: Duan
authors.affiliation: Department of Pathology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200336, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University Shanghai 200433, China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University Shanghai 200433, China.
authors.forename: Anmei
authors.initials: A
authors.lastname: Deng
keywords: Long non-coding RNA; UCA1; colon cancer; metastasis; prognosis