title: Emerging Histopathological and Genetic Parameters of Pituitary Adenomas: Clinical Impact and Recommendation for Future WHO Classification.
abstract: The review assesses immunohistochemical findings of somatostatin receptors and of metalloproteinases in different pituitary adenoma types and the significance of molecular genetic data. Current evidence does not support routine immunohistochemical assessment of somatostatin or dopamine receptor subtype expression on hormone-secreting or nonfunctioning pituitary adenomas. Further prospective studies are needed to define its role for clinical decision making. Until then we suggest to restrict membrane receptor profiling to individual cases or for study purposes. The problems of adenoma expansion and invasion are discussed. Despite partially contradictory publications, proteases clearly play a major role in permission of infiltrative growth of pituitary adenomas. Therefore, detection of at least MMP-2, MMP-9, TIMP-2, and uPA seems to be justified. Molecular characterization is important for familial adenomas, adenomas in MEN, Carney complex, and McCune-Albright syndrome and can gain insight into pathogenesis of sporadic adenomas.
authors.affiliation: Institutes of Pathology and Neuropathology, University of Hamburg, UKE, Martinistraße 52, 20246, Hamburg, Germany. w.saeger@uke.de.
authors.forename: W
authors.initials: W
authors.lastname: Saeger
authors.affiliation: ENDOC Center for Endocrinology, 22587 Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Petersenn
authors.affiliation: Division of Endocrinology and Diabetes, Department of Medicine I, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Schöfl
authors.affiliation: Department of Neurosurgery, Johannes-Wesling-Klinikum Minden, 32429, Minden, Germany.
authors.forename: U J
authors.initials: UJ
authors.lastname: Knappe
authors.affiliation: Department of Endocrinology, Max Planck Institute of Psychiatry, 80804, Munich, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Theodoropoulou
authors.affiliation: Department of Neuropathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054, Erlangen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Buslei
authors.affiliation: Clinic of Neurosurgery, University of Tübingen, 72076, Tübingen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Honegger
mesh_terms: D000236:Adenoma / Q000145:classification* / Q000235:genetics* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000235:genetics; D006801:Humans; D010911:Pituitary Neoplasms / Q000145:classification* / Q000235:genetics* / Q000473:pathology; D014944:World Health Organization
chemical_list: D014408:Biomarkers, Tumor
keywords: Adenoma; Classification; Genetics; Invasion; Pituitary; Receptors