title: Cardiac troponin-I, brain natriuretic peptide and endothelin-1 levels in a rat model of doxorubicin-induced cardiac injury.
abstract: BACKGROUND
  Cardiotoxicity, during or after therapy, is the most serious side effect of doxorubicin (DXR). The risk of developing cardiac impairment increases concomitantly with an increase in the cumulative dose of DXR.
  
  
  OBJECTIVE
  The aim was to evaluate the levels of cardiac troponin-I (cTnI), brain natriuretic peptide (BNP) and endothelin-1 (ET-1) in DXR induced cardiac injury.
  
  
  METHODS
  Thirty-nine Wistar albino rats were divided into three groups; a control group and two-study groups that received low-dose DXR (LDD) and high-dose DXR (HDD) in a weekly schedule for reaching a cumulative dose.
  
  
  RESULTS
  Serum cTnI level was significantly increased in both LDD and HDD-treated groups. Although serum BNP was not significantly increased either LDD or HDD-treated groups, ET-1 levels was significantly increased in only HDD-treated groups. Histopathologic injury was more evident in HDD-treated group.
  
  
  CONCLUSIONS
  Serum cTnI was increased even in LDD and parallel to it low cardiac injury induced by DXR. In the low-dose group, BNP and ET-1 levels were not elevated significant as cTnI despite cardiac injury. Thus, cTnI may be a predictive marker in of DXR-induced cardiotoxicity.
authors.affiliation: Department of Pediatric Oncology, Gulhane Military Medical Academy, Etlik, 06018, Turkey.
authors.forename: Erman
authors.initials: E
authors.lastname: Atas
authors.forename: Erol
authors.initials: E
authors.lastname: Kismet
authors.forename: Vural
authors.initials: V
authors.lastname: Kesik
authors.forename: Baki
authors.initials: B
authors.lastname: Karaoglu
authors.forename: Gokhan
authors.initials: G
authors.lastname: Aydemir
authors.forename: Nadir
authors.initials: N
authors.lastname: Korkmazer
authors.forename: Erkan
authors.initials: E
authors.lastname: Demirkaya
authors.forename: Yıldirim
authors.initials: Y
authors.lastname: Karslioglu
authors.forename: Neval
authors.initials: N
authors.lastname: Yurttutan
authors.forename: Bulent
authors.initials: B
authors.lastname: Unay
authors.forename: Vedat
authors.initials: V
authors.lastname: Koseoglu
authors.forename: Erdal
authors.initials: E
authors.lastname: Gokcay
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D015415:Biomarkers / Q000378:metabolism*; D004317:Doxorubicin / Q000633:toxicity*; D019332:Endothelin-1 / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006331:Heart Diseases / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D019210:Troponin I / Q000378:metabolism*
chemical_list: D000903:Antibiotics, Antineoplastic; D015415:Biomarkers; D019332:Endothelin-1; D019210:Troponin I; D020097:Natriuretic Peptide, Brain; D004317:Doxorubicin