title: In extremely preterm infants, do the Movement Assessment of Infants and the Alberta Infant Motor Scale predict 18-month outcomes using the Bayley-III?
abstract: BACKGROUND
  Extremely preterm infants are at high-risk for neurodevelopmental disabilities. The Movement Assessment of Infants (MAI) and the Alberta Infant Motor Scale (AIMS) have been designed to predict outcome with modest accuracy with the Bayley-I or Bayley-II.
  
  
  OBJECTIVE
  To examine and compare the predictive validity of the MAI and AIMS in determining neurodevelopmental outcome with the Bayley-III.
  
  
  METHODS
  Retrospective cohort study of 160 infants born at ≤ 28 weeks gestation.
  
  
  METHODS
  At their corrected age, infants underwent the MAI at 4 months, the AIMS at 4 and 10-12 months, and the Bayley-III and neurological examination at 18 months. Sensitivity and specificity were calculated.
  
  
  RESULTS
  Infants had a mean gestation of 26.3 ± 1.4 weeks and birth weight of 906 ± 207 g. A high-risk score (≥ 14) for adverse outcome was obtained by 57% of infants on the MAI. On the AIMS, a high-risk score (<5th percentile) was obtained by 56% at 4 months and 30% at 10-12 months. At 18 months, infants with low-risk scores on either the MAI or AIMS had higher cognitive, language, and motor Bayley-III scores than those with high-risk scores. They were less likely to have severe neurodevelopmental impairment. To predict Bayley-III scores <70, sensitivity and specificity were 91% and 49%, respectively, for the MAI and 78% and 48%, respectively, for the AIMS.
  
  
  CONCLUSIONS
  Extremely preterm infants with low-risk MAI at 4 months or AIMS scores at 4 or 10-12 months had better outcomes than those with high-risk scores. However, both tests lack specificity to predict individual neurodevelopmental status at 18 months.
authors.affiliation: Neonatal Follow-Up Clinic, Department of Pediatrics, CHU Sainte-Justine, University of Montreal, Montréal, Québec, Canada. Electronic address: francine.lefebvre.2@umontreal.ca.
authors.forename: Francine
authors.initials: F
authors.lastname: Lefebvre
authors.affiliation: Neonatal Follow-Up Clinic, Department of Pediatrics, CHU Sainte-Justine, University of Montreal, Montréal, Québec, Canada. Electronic address: marie-michele.gagnon.hsj@ssss.gouv.qc.ca.
authors.forename: Marie-Michèle
authors.initials: MM
authors.lastname: Gagnon
authors.affiliation: Neonatal Follow-Up Clinic, Department of Pediatrics, CHU Sainte-Justine, University of Montreal, Montréal, Québec, Canada. Electronic address: thuy.mai.luu@umontreal.ca.
authors.forename: Thuy Mai
authors.initials: TM
authors.lastname: Luu
authors.affiliation: Neonatal Follow-Up Clinic, Department of Pediatrics, CHU Sainte-Justine, University of Montreal, Montréal, Québec, Canada. Electronic address: genevieve.lupien.hsj@ssss.gouv.qc.ca.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Lupien
authors.affiliation: Neonatal Follow-Up Clinic, Department of Pediatrics, CHU Sainte-Justine, University of Montreal, Montréal, Québec, Canada. Electronic address: vdorval@gmail.com.
authors.forename: Véronique
authors.initials: V
authors.lastname: Dorval
mesh_terms: D000328:Adult; D002657:Child Development; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D062071:Infant, Extremely Premature / Q000254:growth & development / Q000502:physiology*; D007231:Infant, Newborn; D009068:Movement; D009460:Neurologic Examination / Q000379:methods*; D012720:Severity of Illness Index
keywords: Alberta Infant Motor Scale; Bayley Scales of Infant and Toddler Development; Extremely preterm infant; Infant outcome; Movement Assessment of Infants