title: The effect of sleeve gastrectomy on serum irisin levels in patients with morbid obesity.
abstract: BACKGROUND
  Irisin, a recently identified myokine, is associated with increased energy expenditure and has a potential role in obesity. Therefore, we investigated circulating irisin levels in morbidly obese patients undergoing sleeve gastrectomy (SG).
  
  
  METHODS
  Thirty morbidly obese patients undergoing SG and 30 healthy subjects were included. All participants were evaluated at baseline and again at three months post-SG. Body weight and height, the lipid profile, and plasma glucose, HbA1c, insulin, and irisin levels were measured at each visit.
  
  
  RESULTS
  The two groups had similar mean age and sex distribution. Serum irisin was significantly lower in the morbidly obese subjects compared with the controls (p = 0.003) and negatively correlated with BMI, body weight, insulin levels, and HOMA-IR (p = 0.006, p = 0.011, p = 0.046, p = 0.048, respectively). When the morbidly obese patients were re-evaluated three months post-SG, their weight and BMI had significantly decreased (both p = 0.001). Similarly, the insulin, HbA1c, HDL-cholesterol, and HOMA-IR values significantly decreased (p = 0.001, p = 0.028, p = 0.006, and p = 0.001, respectively). However, irisin levels remained unchanged (p = 0,267).
  
  
  CONCLUSIONS
  Although the irisin levels were significantly lower in the morbidly obese subjects, they did not change after SG-induced weight loss. (Endokrynol Pol 2016; 67 (5): 481-486).
authors.affiliation: Department of Endocrinology and Metabolism, Tepecik Education and Research Hospital, Izmir,. dr.mustafa.demirpence@gmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Demirpence
authors.forename: Hamiyet
authors.initials: H
authors.lastname: Yilmaz
authors.forename: Ayfer
authors.initials: A
authors.lastname: Colak
authors.forename: Hulya
authors.initials: H
authors.lastname: Yalcin
authors.forename: Burak
authors.initials: B
authors.lastname: Toprak
authors.forename: Hakan
authors.initials: H
authors.lastname: Turkon
authors.forename: Levent
authors.initials: L
authors.lastname: Ugurlu
authors.forename: Cengiz
authors.initials: C
authors.lastname: Aydin
mesh_terms: D000328:Adult; D001786:Blood Glucose; D005260:Female; D005353:Fibronectins / Q000097:blood*; D005743:Gastrectomy; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery
chemical_list: D001786:Blood Glucose; C577593:FNDC5 protein, human; D005353:Fibronectins; D007328:Insulin; D008055:Lipids
keywords: Irisin; bariatric surgery; insulin; obesity; sleeve gastrectomy