title: Managing Metastatic Castration-Resistant Prostate Cancer in the Pre-chemotherapy Setting: A Changing Approach in the Era of New Targeted Agents.
abstract: In recent years, the therapeutic options for treating men with metastatic castration-resistant prostate cancer have increased substantially. The hormonal treatments abiraterone acetate and enzalutamide, the chemotherapeutics docetaxel and cabazitaxel, the radiopharmaceutical alpharadin and the immunotherapeutic Sipuleucel-T have entered the field. Additionally, corticosteroids, which are used extensively, have documented activity but no documented survival benefit. Physicians treating patients with metastatic prostate cancer immediately after castration resistance develops currently have at least four different options to choose from for the first treatment. These therapeutic choices and their several possible ways of sequential use have not yet been compared to each other head-to-head and may never be. Therefore, there is an unmet need to inform their use with prospective clinical data. Additionally, the new indications of docetaxel for hormone naïve prostate cancer is changing the landscape of prostate cancer treatment and questions the traditional classifications 'pre-chemotherapy' and 'post-chemotherapy'. In this work we attempt to address these challenges in the treatment of metastatic castration-resistant prostate cancer with the focus mainly on the non-cytotoxic agents. We try to integrate available clinical and preclinical information to suggest optimal ways of treatment.
authors.affiliation: Division of Clinical Studies, The Institute of Cancer Research, Downs Rd, Sutton, London, Surrey, SM2 5PT, UK.|Drug Development Unit, The Royal Marsden NHS Foundation Trust, London, UK.
authors.forename: Zafeiris
authors.initials: Z
authors.lastname: Zafeiriou
authors.affiliation: Division of Clinical Studies, The Institute of Cancer Research, Downs Rd, Sutton, London, Surrey, SM2 5PT, UK.|Drug Development Unit, The Royal Marsden NHS Foundation Trust, London, UK.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Jayaram
authors.affiliation: Division of Clinical Studies, The Institute of Cancer Research, Downs Rd, Sutton, London, Surrey, SM2 5PT, UK.|Drug Development Unit, The Royal Marsden NHS Foundation Trust, London, UK.
authors.forename: Adam
authors.initials: A
authors.lastname: Sharp
authors.affiliation: Division of Clinical Studies, The Institute of Cancer Research, Downs Rd, Sutton, London, Surrey, SM2 5PT, UK. johann.de-Bono@icr.ac.uk.|Drug Development Unit, The Royal Marsden NHS Foundation Trust, London, UK. johann.de-Bono@icr.ac.uk.
authors.forename: Johann S
authors.initials: JS
authors.lastname: de Bono
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000077143:Docetaxel; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy / Q000379:methods; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy*; D043823:Taxoids / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel