title: [Expression levels of miR-181c-3p and miR-5692b in esophageal cancer and their clinical significance].
abstract: OBJECTIVE
  To study the expression level and clinical significance of miR-181c-3p and miR-5692b in esophageal cancer.
  
  
  METHODS
  The microRNA (miRNA) profiles of esophageal squamous cell carcinoma were analyzed by miRNA microarray in 55 cases of esophageal cancer. The expression levels of miR-181c-3p and miR-5692b from 55 pairs of tumor tissues and adjacent non-neoplastic tissues were determined by qRT-PCR analysis.
  
  
  RESULTS
  Both miR-181c-3p and miR-5692b were significantly up-regulated in tumor tissues compared with adjacent non-neoplastic tissues. Their expression was also significantly associated with tumor size, depth of invasion and clinical tumor stage (P<0.05). High expression of miR-181c-3p and miR-5692b were significantly associated with poor prognosis (P<0.05). Multivariate Cox regression analysis confirmed that high expression of miR-181c-3p and miR-5692b was poor prognostic indicators in esophageal cancer.
  
  
  CONCLUSIONS
  There are significant correlation between miR-181c-3p/miR-5692b expression, clinicopathologic parameters and prognosis. They represent potential prognostic biomarkers in esophageal squamous cell carcinoma.
authors.affiliation: Department of Pathology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Chen
authors.forename: Babayi
authors.initials: B
authors.lastname: Ainiwaer
authors.forename: Song
authors.initials: S
authors.lastname: Qing
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Ma
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
authors.forename: Xuelian
authors.initials: X
authors.lastname: Pang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: E-mail: lxx-patho@163.com.
authors.forename: Xinxia
authors.initials: X
authors.lastname: Li
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D011379:Prognosis; D015854:Up-Regulation
chemical_list: C000608460:MIRN-181 microRNA, human; C540193:MIrn181 microRNA, human; D035683:MicroRNAs