title: Relationship between depressive symptoms, alcohol use, and antiretroviral therapy adherence among HIV-infected, clinic-attending patients in South Africa.
abstract: Despite the prevalence of depression and alcohol use among HIV-infected individuals, few studies have examined their association together in relation to nonadherence to antiretroviral therapy in sub-Saharan Africa. This study examined depressive symptoms, alcohol use, and other psychosocial factors (stigma, demographic characteristics) in relation to nonadherence to antiretroviral therapy among clinic-attending, HIV-infected individuals in South Africa ( n = 101). Nonadherence was assessed using event-level measurement (missed doses over the past weekend). Multivariable logistic regression analyses revealed that only alcohol use, over and above depressive symptoms and education level, was associated with antiretroviral therapy nonadherence(AOR = 1.15; 95%CI = 1.02-1.29; p < .05). Findings point to the independent association of alcohol use and nonadherence to antiretroviral therapy above and beyond depressive symptoms.
authors.affiliation: 1 Massachusetts General Hospital/Harvard Medical School, USA.
authors.forename: Jessica F
authors.initials: JF
authors.lastname: Magidson
authors.affiliation: 2 Stellenbosch University, South Africa.
authors.forename: Wylene
authors.initials: W
authors.lastname: Saal
authors.affiliation: 2 Stellenbosch University, South Africa.
authors.forename: Adriaan
authors.initials: A
authors.lastname: Nel
authors.affiliation: 1 Massachusetts General Hospital/Harvard Medical School, USA.
authors.forename: Jocelyn E
authors.initials: JE
authors.lastname: Remmert
authors.affiliation: 2 Stellenbosch University, South Africa.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Kagee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000523:psychology*; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D003863:Depression / Q000523:psychology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D016015:Logistic Models; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D013019:South Africa; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents
keywords: HIV/AIDS; adherence; alcohol; depression; drinking