title: Iron-catalyzed Cross-Coupling of Propargyl Carboxylates and Grignard Reagents: Synthesis of Substituted Allenes.
abstract: Presented herein is a mild, facile, and efficient iron-catalyzed synthesis of substituted allenes from propargyl carboxylates and Grignard reagents. Only 1-5 mol % of the inexpensive and environmentally benign [Fe(acac)3 ] at -20 °C was sufficient to afford a broad range of substituted allenes in excellent yields. The method tolerates a variety of functional groups.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, SE-10691, Sweden.
authors.forename: Simon N
authors.initials: SN
authors.lastname: Kessler
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, SE-10691, Sweden. jeb@organ.su.se.
authors.forename: Jan-E
authors.initials: JE
authors.lastname: Bäckvall
keywords: Grignard reagents; allenes; chirality; cross-coupling; iron