title: Neurotrophic growth factor responses to lower body resistance training in older adults.
abstract: Resistance exercise is an efficacious stimulus for improving cognitive function in older adults, which may be mediated by the upregulation of blood-borne neurotrophic growth factors (NTFs) like brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1). However, the NTF response to resistance exercise and training in older adults is poorly understood. Therefore, the purpose of this study was to characterize the timing and magnitude of the NTF response following an acute bout of resistance exercise before and after 8 weeks of resistance training. Ten cognitively normal, older adults (ages 60-77 years, five men) were examined. The acute NTF response to resistance exercise was assessed via serum samples drawn at designated time points following exercise. This procedure was then repeated following 8 weeks of resistance training. BDNF increased immediately post-exercise (Δ9% pre-training, Δ11% post-training) then returned to resting levels while IGF-1 remained stable following resistance exercise before and after 8 weeks of resistance training. Basal levels of both NTFs were unaffected by the 8 week training period. We report a transient increase in serum BDNF following a bout of resistance exercise in older adults, which could have implications for the design of interventions seeking to maximize cognitive function in older adults.
authors.affiliation: a School of Kinesiology and Health Studies, Queen's University, 28 Division St., Kingston, ON K7L 3N6, Canada.
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Walsh
authors.affiliation: a School of Kinesiology and Health Studies, Queen's University, 28 Division St., Kingston, ON K7L 3N6, Canada.
authors.forename: Trisha D
authors.initials: TD
authors.lastname: Scribbans
authors.affiliation: a School of Kinesiology and Health Studies, Queen's University, 28 Division St., Kingston, ON K7L 3N6, Canada.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Bentley
authors.affiliation: b Department of Kinesiology, University of Wisconsin, Madison, WI, USA.
authors.forename: J Mikhail
authors.initials: JM
authors.lastname: Kellawan
authors.affiliation: a School of Kinesiology and Health Studies, Queen's University, 28 Division St., Kingston, ON K7L 3N6, Canada.
authors.forename: Brendon
authors.initials: B
authors.lastname: Gurd
authors.affiliation: a School of Kinesiology and Health Studies, Queen's University, 28 Division St., Kingston, ON K7L 3N6, Canada.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Tschakovsky
mesh_terms: D000367:Age Factors; D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D035002:Lower Extremity; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000502:physiology*; D055070:Resistance Training; D013997:Time Factors
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C583557:IGF1 protein, human; D007334:Insulin-Like Growth Factor I; C579455:BDNF protein, human
keywords: BDNF; IGF-1; aging; cognitive function; fonction cognitive; neuroplasticity; neuroplasticité; vieillissement