title: Lamellar Macular Holes Associated with End-Stage Exudative Age-Related Macular Degeneration.
abstract: BACKGROUND
  Reports of lamellar macular holes (LMHs) with underlying age-related macular degeneration (AMD) are rare, and the specific definition, pathogenesis and surgical recommendations for this macular condition remain unclear.
  
  
  OBJECTIVE
  To present a series of LMHs in eyes with underlying end-stage AMD, and describe optical coherence tomography (OCT) detection of associated morphologic abnormalities.
  
  
  METHODS
  We reviewed the files of consecutive patients diagnosed with LMH and underlying end-stage AMD between September 2007 and September 2011.
  
  
  RESULTS
  Sixteen eyes of 14 patients were included in this study. The average follow-up after the OCT-established diagnosis of LMH was 19.8 months (range 4-48). The average visual acuity (VA) at last follow-up visit was 20/400 (20/60-20/1200). The best-corrected VA was stable in 10 eyes (62.5%) and deteriorated in 6 (37.5%). There was a statistically significant correlation between VA and minimal foveal thickness (r = -0.598, P = 0.014).
  
  
  CONCLUSIONS
  In this series of LMHs with underlying AMD the OCT findings were intraretinal fluid, cystic spaces and window defect.
authors.forename: Ori
authors.initials: O
authors.lastname: Segal
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Ferencz
authors.forename: Michael
authors.initials: M
authors.lastname: Mimouni
authors.forename: Ronit
authors.initials: R
authors.lastname: Nesher
authors.forename: Perri
authors.initials: P
authors.lastname: Cohen
authors.forename: Arie Y
authors.initials: AY
authors.lastname: Nemet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008268:Macular Degeneration / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012167:Retinal Perforations / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity