title: Personalizing supportive care in oncology patients using pharmacogenetic-driven treatment pathways.
abstract: Cancer patients frequently suffer from disease- and treatment-related pain, nausea and depression, which severely reduces patients' quality of life. It is critical that clinicians are aware of drug-gene interactions and recognize the utility of applying pharmacogenetic information to personalize and improve supportive care. Pharmacogenetic-based algorithms may enhance clinical outcomes by allowing the clinician to select the 'least genetically vulnerable' drug. This review summarizes clinically relevant drug-gene interactions and presents pharmacogenetic-driven treatment pathways for depression, nausea/vomiting and pain. Ideally, this review provides a resource for clinicians to consult when selecting pharmacotherapy for a patient who presents with limited pharmacogenetic test results, with the hope of better controlling burdensome symptoms and improving the quality of life for cancer patients.
authors.affiliation: Wingate University School of Pharmacy, 515 N Main St, Wingate, NC 28174, USA.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Andersen
authors.affiliation: University of North Carolina Eshelman School of Pharmacy, CB #7355, Chapel Hill, NC 27599, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Johnson
authors.affiliation: University of North Carolina Eshelman School of Pharmacy, CB #7355, Chapel Hill, NC 27599, USA.|Levine Cancer Institute, Carolinas HealthCare System, 1021 Morehead Medical Drive, Charlotte, NC 28204, USA.
authors.forename: Jai N
authors.initials: JN
authors.lastname: Patel
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D003863:Depression / Q000188:drug therapy / Q000235:genetics / Q000523:psychology; D004347:Drug Interactions; D006801:Humans; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D010146:Pain / Q000188:drug therapy / Q000235:genetics; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D057285:Precision Medicine; D011788:Quality of Life; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents
keywords: analgesics; antidepressants; antiemetics; cancer; oncology; personalize; pharmacogenetics; supportive care