title: The UniProtKB guide to the human proteome.
abstract: Advances in high-throughput and advanced technologies allow researchers to routinely perform whole genome and proteome analysis. For this purpose, they need high-quality resources providing comprehensive gene and protein sets for their organisms of interest. Using the example of the human proteome, we will describe the content of a complete proteome in the UniProt Knowledgebase (UniProtKB). We will show how manual expert curation of UniProtKB/Swiss-Prot is complemented by expert-driven automatic annotation to build a comprehensive, high-quality and traceable resource. We will also illustrate how the complexity of the human proteome is captured and structured in UniProtKB. Database URL: www.uniprot.org.
authors.affiliation: SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 Rue Michel Servet, Geneva 4, 1211, Switzerland lionel.breuza@isb-sib.ch.
authors.forename: Lionel
authors.initials: L
authors.lastname: Breuza
authors.affiliation: SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 Rue Michel Servet, Geneva 4, 1211, Switzerland.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Poux
authors.affiliation: SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 Rue Michel Servet, Geneva 4, 1211, Switzerland.
authors.forename: Anne
authors.initials: A
authors.lastname: Estreicher
authors.affiliation: SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 Rue Michel Servet, Geneva 4, 1211, Switzerland.
authors.forename: Maria Livia
authors.initials: ML
authors.lastname: Famiglietti
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Michele
authors.initials: M
authors.lastname: Magrane
authors.affiliation: SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 Rue Michel Servet, Geneva 4, 1211, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Tognolli
authors.affiliation: SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 Rue Michel Servet, Geneva 4, 1211, Switzerland.
authors.forename: Alan
authors.initials: A
authors.lastname: Bridge
authors.affiliation: SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 Rue Michel Servet, Geneva 4, 1211, Switzerland.
authors.forename: Delphine
authors.initials: D
authors.lastname: Baratin
authors.affiliation: SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 Rue Michel Servet, Geneva 4, 1211, Switzerland.
authors.forename: Nicole
authors.initials: N
authors.lastname: Redaschi
mesh_terms: D001331:Automation; D030562:Databases, Protein; D016678:Genome; D006801:Humans; D051188:Knowledge Bases; D010641:Phenotype; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry; D020543:Proteome / Q000235:genetics*; D040901:Proteomics / Q000379:methods*; D017393:RNA Editing; D012984:Software
chemical_list: D011506:Proteins; D020543:Proteome