title: Anacardic acid sensitizes prostate cancer cells to radiation therapy by regulating H2AX expression.
abstract: Anacardic acid (6-pentadecylsalicylic acid, AA), a natural compound isolated from the traditional medicine Amphipterygiumadstringens, has been reported as potential antitumor agents in various cancers including prostate cancer (PC). However, the effects and mechanism of AA on the radiosensitivity of prostate cancer remains unknown. The results indicated that AA exhibited strong antitumor activity in PC cell lines, either as a single agentor in combination with radiation. AA significantly induced the downregulation of H2AX and p-H2AX expression, increase of cell apoptosis and decreasing of cell invasion, which were reversed by overexpressed H2AX. These results suggest that AA sensitize prostate cancer cells to radiation therapy by repressing H2AX expression.
authors.affiliation: Department of Urology, The Third Hospital of Central South University Changsha 410013, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Yao
authors.affiliation: Department of Urology, The Third Hospital of Central South University Changsha 410013, China.
authors.forename: Xianzhen
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Urology, The Third Hospital of Central South University Changsha 410013, China.
authors.forename: Leye
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Urology, The Third Hospital of Central South University Changsha 410013, China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Urology, The Third Hospital of Central South University Changsha 410013, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Yin
authors.affiliation: Department of Urology, The Third Hospital of Central South University Changsha 410013, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zeng
authors.affiliation: Department of Urology, The Third Hospital of Central South University Changsha 410013, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Urology, The Third Hospital of Central South University Changsha 410013, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Tan
mesh_terms: D048729:Anacardic Acids / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D015536:Down-Regulation; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D010766:Phosphorylation; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
chemical_list: D048729:Anacardic Acids; C468783:H2AX protein, human; D006657:Histones; D011838:Radiation-Sensitizing Agents; C088115:anacardic acid
keywords: Anacardic acid; H2AX; prostate cancer; radio therapy