title: Epidemiological and clinical characteristics of neurobrucellosis case patients in Tunisia.
abstract: OBJECTIVE
  We aimed to identify epidemiological, clinical, therapeutic, diagnostic, and outcome characteristics of neurobrucellosis case patients in Tunisia.
  
  
  METHODS
  We conducted a retrospective and descriptive study over a 17-year period (January 1997-December 2013). We included all neurobrucellosis patients hospitalized in the infectious disease department of La Rabta Hospital of Tunis during the study period.
  
  
  RESULTS
  A total of 13 patients were included in the study: 9 men and 4 women. Mean age was 31.6 years. Six patients presented with meningitis, three with encephalitis, two with meningoencephalitis, and two with meningo-myeloradiculitis. All patients had a lumbar puncture performed. Eleven patients had an abnormal cerebrospinal fluid (CSF) (84.6%): lymphocytic pleocytosis in seven patients, high level of CSF proteins in 11, and low level of CSF glucose in seven. All patients had a positive Brucella serological test in blood. A Brucella serological test was also performed in CSF and was positive for 10 patients (77%). A total of nine patients had a cerebral CT scan and/or MRI performed and abnormalities were observed in six patients. Antibiotic therapy was prescribed to all patients: a combination of rifampicin and co-trimoxazole (n=9) or doxycycline (n=4) for an average duration of eight months. Two patients also received steroids. A positive outcome was observed in 10 patients. Three patients were lost to follow up.
  
  
  CONCLUSIONS
  Brucellosis may be severe when neurological involvement occurs. Brucellosis should be considered in the event of any neurological involvement associated with suggestive epidemiological features.
authors.affiliation: Service des maladies infectieuses, hôpital la Rabta, Tunis, Tunisie; Université Tunis El Manar - faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: I
authors.initials: I
authors.lastname: Oueslati
authors.affiliation: Service des maladies infectieuses, hôpital la Rabta, Tunis, Tunisie; Université Tunis El Manar - faculté de médecine de Tunis, Tunis, Tunisie. Electronic address: aida.berricheg@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Berriche
authors.affiliation: Service des maladies infectieuses, hôpital la Rabta, Tunis, Tunisie; Université Tunis El Manar - faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: L
authors.initials: L
authors.lastname: Ammari
authors.affiliation: Service des maladies infectieuses, hôpital la Rabta, Tunis, Tunisie; Université Tunis El Manar - faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: R
authors.initials: R
authors.lastname: Abdelmalek
authors.affiliation: Service des maladies infectieuses, hôpital la Rabta, Tunis, Tunisie; Université Tunis El Manar - faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: F
authors.initials: F
authors.lastname: Kanoun
authors.affiliation: Service des maladies infectieuses, hôpital la Rabta, Tunis, Tunisie; Université Tunis El Manar - faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: B
authors.initials: B
authors.lastname: Kilani
authors.affiliation: Service des maladies infectieuses, hôpital la Rabta, Tunis, Tunisie; Université Tunis El Manar - faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: H
authors.initials: H
authors.lastname: Tiouiri Benaissa
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000822:Animal Husbandry; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D002002:Brucella / Q000276:immunology; D002006:Brucellosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology*; D020806:Central Nervous System Bacterial Infections / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D003611:Dairy Products / Q000009:adverse effects / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D005516:Food Microbiology; D006801:Humans; D008297:Male; D059906:Neuroimaging; D009784:Occupational Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D012189:Retrospective Studies; D016896:Treatment Outcome; D014416:Tunisia / Q000453:epidemiology
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D002556:Cerebrospinal Fluid Proteins
keywords: Co-trimoxazole; Neurobrucellose; Neurobrucellosis; Rifampicin; Rifampicine