title: Relationship between vitamin D deficiency and visually evoked potentials in multiple sclerosis.
abstract: OBJECTIVE
  To evaluate the possible relationship between serum 25-OH vitamin D levels and visually evoked potentials (VEP) in patients with multiple sclerosis (MS), residents in the south zone of Gran Canaria.
  
  
  METHODS
  The study included 49 patients with MS, on whom 25-OH-vitamin D was determined, along with VEP, and a neurological examination to determine incapacity. Clinical variables, such as a history of optic neuritis were recorded.
  
  
  RESULTS
  The mean value of 25-OH-vitamin D of the patients was 28.1±9.5ng/ml. The VEP latency was 119.1±23.2ms and the amplitude, 8.5±4.4 μV. Patients with a higher 25-OH-vitamin D had a greater number of outbreaks in the year prior to the study (P=.049), and those with vitamin D deficiency and previous optic neuritis showed no reduction in the amplitude of the VEP (P=.006).
  
  
  CONCLUSIONS
  Patients with vitamin D deficiency have lower clinical activity of the MS and show no axonal involvement in VEP after having suffered optic neuritis. These relationships, although statistically significant, do not seem clinically plausible, thus new studies are needed to try and confirm this possible relationship.
authors.affiliation: Unidad de Neurooftalmología, Servicio de Neurología, Hospital Universitario Insular de Gran Canaria, Complejo Hospitalario Insular Materno-Infantil, Las Palmas de Gran Canaria, España. Electronic address: plm_mf@hotmail.com.
authors.forename: P
authors.initials: P
authors.lastname: López-Méndez
authors.affiliation: Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, España; Hospital Universitario Insular de Gran Canaria. Unidad Metabólica Ósea. Complejo Hospitalario Insular Materno-Infantil, Las Palmas de Gran Canaria, España.
authors.forename: M
authors.initials: M
authors.lastname: Sosa-Henríquez
authors.affiliation: Unidad de Neurooftalmología, Servicio de Oftalmología, Hospital Universitario Insular de Gran Canaria, Complejo Hospitalario Insular Materno-Infantil, Las Palmas de Gran Canaria, España.
authors.forename: Á
authors.initials: Á
authors.lastname: Ruiz-Pérez
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D009902:Optic Neuritis; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000503:physiopathology*
chemical_list: D014807:Vitamin D
keywords: Axonal damage; Brote; Daño axonal; Demyelination; Desmielinización; Esclerosis múltiple; Multiple sclerosis; Outbreak; Potenciales evocados visuales; Visually evoked potentials; Vitamin D; Vitamina D