title: Reactive Oxygen Species and Targeted Therapy for Pancreatic Cancer.
abstract: Pancreatic cancer is the fourth leading cause of cancer-related death in the United States. Reactive oxygen species (ROS) are generally increased in pancreatic cancer cells compared with normal cells. ROS plays a vital role in various cellular biological activities including proliferation, growth, apoptosis, and invasion. Besides, ROS participates in tumor microenvironment orchestration. The role of ROS is a doubled-edged sword in pancreatic cancer. The dual roles of ROS depend on the concentration. ROS facilitates carcinogenesis and cancer progression with mild-to-moderate elevated levels, while excessive ROS damages cancer cells dramatically and leads to cell death. Based on the recent knowledge, either promoting ROS generation to increase the concentration of ROS with extremely high levels or enhancing ROS scavenging ability to decrease ROS levels may benefit the treatment of pancreatic cancer. However, when faced with oxidative stress, the antioxidant programs of cancer cells have been activated to help cancer cells to survive in the adverse condition. Furthermore, ROS signaling and antioxidant programs play the vital roles in the progression of pancreatic cancer and in the response to cancer treatment. Eventually, it may be the novel target for various strategies and drugs to modulate ROS levels in pancreatic cancer therapy.
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Lun
authors.identifier: 0000-0003-1936-3971
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Jiahui
authors.identifier: 0000-0003-1845-9234
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Liang
authors.identifier: 0000-0002-3330-4735
authors.initials: L
authors.lastname: Zong
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Xin
authors.identifier: 0000-0003-0509-7510
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Ke
authors.identifier: 0000-0003-3148-9921
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Zhengdong
authors.identifier: 0000-0003-0234-5478
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Ligang
authors.identifier: 0000-0002-4140-9158
authors.initials: L
authors.lastname: Nan
authors.affiliation: Department of General Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Xuqi
authors.identifier: 0000-0002-2497-020X
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Wei
authors.identifier: 0000-0001-5701-3230
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of General Surgery, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Tao
authors.identifier: 0000-0001-6680-9302
authors.initials: T
authors.lastname: Shan
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Qingyong
authors.identifier: 0000-0001-8977-320X
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Zhenhua
authors.identifier: 0000-0003-2203-0991
authors.initials: Z
authors.lastname: Ma
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D000975:Antioxidants / Q000378:metabolism*; D017209:Apoptosis; D063646:Carcinogenesis; D004249:DNA Damage; D018450:Disease Progression; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D017382:Reactive Oxygen Species