title: Arterial Spin Labeling Perfusion Study in the Patients with Subacute Mild Traumatic Brain Injury.
abstract: BACKGROUND
  This study uses a MRI technique, three-dimension pulse continuous arterial spin labeling (3D-PCASL), to measure the patient's cerebral blood flow (CBF) at the subacute stage of mild traumatic brain injury (MTBI) in order to analyze the relationship between cerebral blood flow and neurocognitive deficits.
  
  
  OBJECTIVE
  To provide the relationship between cortical CBF and neuropsychological dysfunction for the subacute MTBI patients.
  
  
  METHODS
  After MTBI, perfusion MR imaging technique (3D-PCASL) measures the CBF of MTBI patients (n = 23) within 1 month and that of normal controls (n = 22) to determine the quantity and location of perfusion defect. The correlation between CBF abnormalities and cognitive deficits was elucidated by combining the results of the neuropsychological tests of the patients.
  
  
  RESULTS
  We observed a substantial reduction in CBF in the bilateral frontal and left occipital cortex as compared with the normal persons. In addition, there were correlation between post concussive symptoms (including dizziness and simulator sickness) and CBF in the hypoperfused areas. The more severe symptom was correlated with higher CBF in bilateral frontal and left occipital lobes.
  
  
  CONCLUSIONS
  First, this study determined that despite no significant abnormality detected on conventional CT and MRI studies, hypoperfusion was observed in MTBI group using 3D-PCASL technique in subacute stage, which suggested that this approach may increase sensitivity to MTBI. Second, the correlation between CBF and the severity of post concussive symptoms suggested that changes in cerebral hemodynamics may play a role in pathophysiology underlies the symptoms.
authors.affiliation: Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, New Taipei City, Taiwan.|Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, New Taipei City, Taiwan.
authors.forename: Che-Ming
authors.initials: CM
authors.lastname: Lin
authors.affiliation: Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, New Taipei City, Taiwan.|Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, New Taipei City, Taiwan.
authors.forename: Ying-Chi
authors.initials: YC
authors.lastname: Tseng
authors.affiliation: Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, New Taipei City, Taiwan.|Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, New Taipei City, Taiwan.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Hsu
authors.affiliation: Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, New Taipei City, Taiwan.|Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, New Taipei City, Taiwan.|Chia-Yi Hospital, Ministry of Health and Welfare, Chiayi City, Taiwan.
authors.forename: Chi-Jen
authors.initials: CJ
authors.lastname: Chen
authors.affiliation: Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, New Taipei City, Taiwan.|Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, New Taipei City, Taiwan.
authors.forename: David Yen-Ting
authors.initials: DY
authors.lastname: Chen
authors.affiliation: Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, New Taipei City, Taiwan.|Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, New Taipei City, Taiwan.
authors.forename: Feng-Xian
authors.initials: FX
authors.lastname: Yan
authors.affiliation: Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, New Taipei City, Taiwan.|Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, Taiwan.
authors.forename: Wen-Ta
authors.initials: WT
authors.lastname: Chiu
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009778:Occipital Lobe / Q000098:blood supply*; D012039:Regional Blood Flow; D013113:Spin Labels
chemical_list: D013113:Spin Labels