title: Effect of Topical Estrogen in the Mangement of Traumatic Facial Wounds.
abstract: BACKGROUND
  Acute skin wound healing is a complicated process comprising various phases. Recent animal studies have shown that steroid sex hormones such as estrogen maybe helpful in the regulation of several pathophysiologic stages that are involved in wound healing. In this study we examined the effects of topical estrogen in the treatment of traumatic facial wounds.
  
  
  METHODS
  Patients referred to Luqman Hospital, Tehran with traumatic wounds were enrolled in this case-control study into two groups of equal size. From the second week of the study, topical estrogen (0.625 mg conjugated topical estrogen ointment) was administered in the case group, while the control group received a Eucerin dressing only. The two groups were then compared in terms of wound healing rate on Day 7,14, and 30.
  
  
  RESULTS
  Thirty patients with mean age of 16.02+36.23 years were compared in the control and estrogen-treated groups. After treatment, no scars or keloids were observed in either group. The wound area in the estrogen group was lower than that in the control group on Day 14 and 30, but the difference was not significant (P>0.05). Healing rates in the control group on Day 14 (7.1+42.3 vs.50.3+4.9 mm2) and Day 30 (1.9+93.5 vs. + 97.3+0.6 mm2) (were lower than those in the estrogen group, but the differences were not significant (P>0.05). Findings show that the required time for wound healing in the estrogen-treated group was lower than that in the control group, but the difference was not significant (P>0.05).
  
  
  CONCLUSIONS
  Based on this study, topical estrogen has no effect on the rate of wound healing or the rate of wound area.
authors.affiliation: Department of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Amirhosein
authors.initials: SA
authors.lastname: Ghazizadeh Hashemi
authors.affiliation: Department of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Behrooz
authors.initials: B
authors.lastname: Barati
authors.affiliation: Department of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hosein
authors.initials: H
authors.lastname: Mohammadi
authors.affiliation: Students Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Masumeh
authors.initials: M
authors.lastname: Saeidi
authors.affiliation: Students Research Committee, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Bahreini
authors.affiliation: Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Kiani
keywords: Effect; Estrogen; Traumatic Wounds; Treatment