title: [Hypercalcemia related to PTH-rP revealing malignant hepatic epithelioid hemangioendothelioma].
abstract: Hypercalcemia caused by tumor production of PTH-rp occurs most often in cases of squamous cell carcinoma of the lung, aerodigestive tract cancer, gynecological cancer and lymphoma. We report an exceptional case of PTH-rp related to a hepatic hemangioendothelioma. A 70 years-old male admitted for deterioration of the general state. The laboratory investigations revealed hypercalcemia, related to tumor production of PTH-rp. Imaging revealed tumoral hepatic lesions. Histopathological study and immunohistochemistry showed diffuse response for CD31 marker, CK20 (+) with CK7 (-) and hepatocyt antigen (-). The diagnosis of PTH-rp related to hepatic hemangioendothelioma was make. The patient died with recurrence of fatal hypercalcemia. Management of patients presenting with humoral hypercalcemia includes a vigorous search for tumor lesions. Elevated PTH-rp can be a bad prognostic factor. In front of tumoral liver lesions, a hepatic epithelioid hemangioendothelioma must be considered. Immunohistochemistry is necessary to make diagnosis.
authors.affiliation: Service de médecine interne, Hôpital Charles Nicolle, Faculté de médecine, Université El Manar, Tunis, Tunisie.
authors.forename: Imène
authors.initials: I
authors.lastname: Boukhris
authors.affiliation: Service de médecine interne, Hôpital Charles Nicolle, Faculté de médecine, Université El Manar, Tunis, Tunisie.
authors.forename: Samira
authors.initials: S
authors.lastname: Azzabi
authors.affiliation: Service de médecine interne, Hôpital Charles Nicolle, Faculté de médecine, Université El Manar, Tunis, Tunisie.
authors.forename: Ines
authors.initials: I
authors.lastname: Kéchaou
authors.affiliation: Service de médecine interne, Hôpital Charles Nicolle, Faculté de médecine, Université El Manar, Tunis, Tunisie.
authors.forename: Eya
authors.initials: E
authors.lastname: Chérif
authors.affiliation: Service de médecine interne, Hôpital Charles Nicolle, Faculté de médecine, Université El Manar, Tunis, Tunisie.
authors.forename: Chékib
authors.initials: C
authors.lastname: Kooli
authors.affiliation: Laboratoire d'anatomopathologie, Institut Salah Azaiez, Tunis, Tunisie.
authors.forename: Khaled Ben
authors.initials: KB
authors.lastname: Romdhane
authors.affiliation: Laboratoire de biochimie, Hôpital La Rabta, Tunis, Tunisie.
authors.forename: Souheil
authors.initials: S
authors.lastname: Omar
authors.affiliation: Service de médecine interne, Hôpital Charles Nicolle, Faculté de médecine, Université El Manar, Tunis, Tunisie.
authors.forename: Narjes
authors.initials: N
authors.lastname: Khalfallah
mesh_terms: D000368:Aged; D018323:Hemangioendothelioma, Epithelioid / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009384:Paraneoplastic Endocrine Syndromes / Q000209:etiology / Q000473:pathology; D044162:Parathyroid Hormone-Related Protein / Q000378:metabolism / Q000502:physiology*
chemical_list: C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein
keywords: PTH-rp; hemangioendothelioma; hypercalcemia; liver