title: Myocardial T1 rho mapping of patients with end-stage renal disease and its comparison with T1 mapping and T2 mapping: A feasibility and reproducibility study.
abstract: To evaluate the feasibility of T1 rho mapping in myocardium at 3T and to determine whether T1 rho mapping could better characterize myocardial injury in end-stage renal disease (ESRD) patients compared to T1 and T2 mapping.
  
  
  
  T1 rho mapping, T1 mapping, and T2 mapping were performed at 3T on 35 healthy volunteers (15 males, 20 females, 40.7 ± 13.6 years) and 32 ESRD patients (16 males, 16 females, 48.6 ± 11.9 years). The mean T1 rho, T1 , and T2 values were compared using Student's t-test and correlated with cardiac function parameters, including peak ejection rate (PER), short-axis percent thickening (SAPT), peak filling rate (PFR), and time to peak filling (TTPF).
  
  
  
  The mean T1 rho values (49.4 ± 2.6 msec vs. 52.2 ± 4.0 msec, P = 0.001) and T2 values (50.5 ± 2.5 msec vs. 54.1 ± 4.0 msec, P < 0.001) were significantly different between the volunteers and patients, but there were no significant differences between the two groups in the T1 values (1253.1 ± 71.6 msec vs. 1273.4 ± 41.7 msec, P = 0.157). The mean T1 rho values were negatively correlated with the PER (r = -0.397; P = 0.03), SAPT (r = -0.688; P < 0.001), and PFR (r = -0.537; P = 0.002), whereas positively correlated with the TTPF (r = 0.677; P < 0.001). The mean T2 values were negatively correlated only with the SAPT (r = -0.427; P = 0.019) in the ESRD patients.
  
  
  
  T1 rho mapping of the myocardium is feasible at 3T. T1 rho values are higher in ESRD patients and relate to cardiac function, which may better characterize myocardial injury than can T1 and T2 . J. Magn. Reson. Imaging 2016;44:723-731.
authors.affiliation: Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong SAR, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Zhang
authors.affiliation: Department of Nephology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.affiliation: Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.
authors.forename: Yuan-Cheng
authors.initials: YC
authors.lastname: Wang
authors.affiliation: Department of Imaging and Interventional Radiology, Prince of Wales Hospital, the Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
authors.forename: Yi-Xiang
authors.initials: YX
authors.lastname: Wang
authors.affiliation: Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.
authors.forename: Shenghong
authors.initials: S
authors.lastname: Ju
mesh_terms: D000328:Adult; D000368:Aged; D057791:Cardiac Imaging Techniques / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging* / Q000209:etiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000000981:diagnostic imaging* / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: T1 mapping; T1rho; T2 mapping; cardiac function; endstage renal disease; myocardial injury