title: Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil.
abstract: Drug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and trypanosomiasis, has led to the search and development of alternative drugs from plant origins. In this context, the essential oil extracted by hydro-distillation from Lantana camara leaves was tested against Leishmania braziliensis and Trypanosoma cruzi. The results demonstrated that L. camara essential oil inhibited T. cruzi and L. braziliensis with IC50 of 201.94 μg/mL and 72.31 μg/mL, respectively. L. camara essential oil was found to be toxic to NCTC929 fibroblasts at 500 μg/mL (IC50 = 301.42 μg/mL). The composition of L. camara essential oil analyzed by gas chromatography-mass spectrometry (GC/MS) revealed large amounts of (E)-caryophyllene (23.75%), biciclogermacrene (15.80%), germacrene D (11.73%), terpinolene (6.1%), and sabinene (5.92%), which might be, at least in part, responsible for its activity. Taken together, our results suggest that L. camara essential oil may be an important source of therapeutic agents for the development of alternative drugs against parasitic diseases.
authors.affiliation: Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil. lmarivando@hotmail.com.|Post-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, Brazil. lmarivando@hotmail.com.
authors.forename: Luiz Marivando
authors.initials: LM
authors.lastname: Barros
authors.affiliation: Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil. duarte105@yahoo.com.br.|Post-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, Brazil. duarte105@yahoo.com.br.
authors.forename: Antonia Eliene
authors.initials: AE
authors.lastname: Duarte
authors.affiliation: Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil.
authors.forename: Maria Flaviana Bezerra
authors.initials: MF
authors.lastname: Morais-Braga
authors.affiliation: Post-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, Brazil. memypw@yahoo.com.br.
authors.forename: Emily Pansera
authors.initials: EP
authors.lastname: Waczuk
authors.affiliation: Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil. mcvegagomez@gmail.com.
authors.forename: Celeste
authors.initials: C
authors.lastname: Vega
authors.affiliation: Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil. nadghia.fl@gmail.com.
authors.forename: Nadghia Figueiredo
authors.initials: NF
authors.lastname: Leite
authors.affiliation: Program of Post-Graduation in Molecular Bioprospection, Laboratory of Pharmacology and Molecular Chemistry, Chemistry Biology Department, Regional University of Cariri, Crato, CEP 63105-000, Brazil. irwin.alencar@urca.br.
authors.forename: Irwin Rose Alencar
authors.initials: IR
authors.lastname: de Menezes
authors.affiliation: Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil. hdmcoutinho@gmail.com.
authors.forename: Henrique Douglas Melo
authors.initials: HD
authors.lastname: Coutinho
authors.affiliation: Post-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, Brazil. jbtrocha@yahoo.com.br.
authors.forename: João Batista Teixeira
authors.initials: JB
authors.lastname: Rocha
authors.affiliation: Post-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, Brazil. kamdemjeanpaul2005@yahoo.fr.|Departamenro de Bioquímica, Instituto de Ciências Básica da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre-RS, CEP 90035-003, Brazil. kamdemjeanpaul2005@yahoo.fr.
authors.forename: Jean Paul
authors.initials: JP
authors.lastname: Kamdem
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D054697:Cytostatic Agents / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D032410:Lantana / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D051379:Mice; D009822:Oils, Volatile / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D054697:Cytostatic Agents; D009822:Oils, Volatile
keywords: Lantana camara; Leishmania braziliensis; Trypanosoma cruzi; essential oil