title: Substrate-Dependent Mechanistic Divergence in Decarboxylative Heck Reaction at Room Temperature.
abstract: We report herein a Pd(II)-catalyzed Heck-type coupling between arene carboxylic acids and alkenes at room temperature. Mechanistically, the reaction proceeds in two distinct pathways where electron-rich substrates undergo a palladium(II)-catalyzed decarboxylation and electron-deficient substrates proceed through silver(I)-assisted decarboxylation. Dimethyl sulfoxide (DMSO) or sulfide ligands have positive and negative roles in the reaction outcome, respectively. The present protocol is combined for the peptide modification under mild reaction conditions.
authors.affiliation: Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India.|Academy of Scientific and Innovative Research , Kolkata-700032, West Bengal, India.
authors.forename: Asik
authors.initials: A
authors.lastname: Hossian
authors.affiliation: Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India.|Academy of Scientific and Innovative Research , Kolkata-700032, West Bengal, India.
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Bhunia
authors.affiliation: Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India.|Academy of Scientific and Innovative Research , Kolkata-700032, West Bengal, India.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Jana