title: IGF-I CA19 repeat polymorphisms and cancer risk: a meta-analysis.
abstract: IGF-I CA repeat polymorphisms, especially the allele containing CA19 repeats, have been reported to be associated with the risk for various types of cancers. However, the results still remain controversial and ambiguous. This meta-analysis was performed to evaluate the association between IGF-I CA19 repeat polymorphisms and the risk of cancer. Total 18 studies with IGF-I CA19 repeat genotyping on 9,873 patients and 15,607 controls were analyzed. We used random-effects model with a pooled OR of 0.69 (95% CI = 0.60-0.79) for the recessive genetic model, 0.97 (95% CI = 0.86-1.10) for the dominant genetic model, 0.99 (95% CI = 0.86-1.14) for the homozygote comparison and 1.06 (95% CI = 0.91-1.23) for the heterozygote comparison. In the subgroup analysis of recessive model, OR (95% CI) was 0.65 (0.52-0.80) in breast cancer, 0.68 (0.53-0.86) in prostate cancer, and 0.71 (0.52-0.96) in Caucasian. In conclusion, IGF-1 CA19 repeat polymorphisms are unlikely to be a major determinant of susceptibility to cancer. However, the subgroup analysis of recessive model indicates that IGF-I CA19 repeat polymorphisms may reduce the risk of certain types of cancer or in a specific population.
authors.affiliation: Department of Radiotherapy, Taizhou People's Hospital Taizhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Taizhou People's Hospital Taizhou, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Shen
authors.affiliation: Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Chi
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Hong-Cheng
authors.initials: HC
authors.lastname: Zhu
authors.affiliation: Department of Radiotherapy, Second People's Hospital of Lian Yungang Lian Yungang, China.
authors.forename: Qu
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Nanjing Medical University Nanjing, China.
authors.forename: Shu-Tong
authors.initials: ST
authors.lastname: Shen
authors.affiliation: Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Xin-Chen
authors.initials: XC
authors.lastname: Sun
authors.affiliation: Department of Radiotherapy, Taizhou People's Hospital Taizhou, China.
authors.forename: Sheng-Bin
authors.initials: SB
authors.lastname: Dai
keywords: CA19 repeat; IGF-I; cancer; meta-analysis; polymorphism