title: Autonomic nervous system-mediated effects of galanin-like peptide on lipid metabolism in liver and adipose tissue.
abstract: Galanin-like peptide (GALP) is a neuropeptide involved in the regulation of feeding behavior and energy metabolism in mammals. While a weight loss effect of GALP has been reported, its effects on lipid metabolism have not been investigated. The aim of this study was to determine if GALP regulates lipid metabolism in liver and adipose tissue via an action on the sympathetic nervous system. The respiratory exchange ratio of mice administered GALP intracerebroventricularly was lower than that of saline-treated animals, and fatty acid oxidation-related gene mRNA levels were increased in the liver. Even though the respiratory exchange ratio was reduced by GALP, this change was not significant when mice were treated with the sympatholytic drug, guanethidine. Lipolysis-related gene mRNA levels were increased in the adipose tissue of GALP-treated mice compared with saline-treated animals. These results show that GALP stimulates fatty acid β-oxidation in liver and lipolysis in adipose tissue, and suggest that the anti-obesity effect of GALP may be due to anorexigenic actions and improvement of lipid metabolism in peripheral tissues via the sympathetic nervous system.
authors.affiliation: Department of Health and Nutrition, University of Human Arts and Sciences, Saitama, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirako
authors.affiliation: Department of Internal Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Wada
authors.affiliation: Faculty of Health Care, Kiryu University, Gunma, Japan.
authors.forename: Haruaki
authors.initials: H
authors.lastname: Kageyama
authors.affiliation: Department of Exercise and Sports Physiology, Hoshi University School of Pharmacy and Pharmaceutical Science, Tokyo, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Takenoya
authors.affiliation: Department of Internal Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Izumida
authors.affiliation: Department of Clinical Dietetics &Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
authors.forename: Hyounju
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Clinical Dietetics &Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Iizuka
authors.affiliation: Department of Clinical Dietetics &Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
authors.forename: Akiyo
authors.initials: A
authors.lastname: Matsumoto
authors.affiliation: Tokyo Shokuryo Dietitian Academy, Tokyo, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Okabe
authors.affiliation: Hoshi University School of Pharmacy and Pharmaceutical Sciences Global Research Center for Innovative Life Science Peptide Drug Innovation, Tokyo, Japan.
authors.forename: Ai
authors.initials: A
authors.lastname: Kimura
authors.affiliation: Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan.
authors.forename: Mamiko
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamanaka
authors.affiliation: Hoshi University School of Pharmacy and Pharmaceutical Sciences Global Research Center for Innovative Life Science Peptide Drug Innovation, Tokyo, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Shioda
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000294:innervation* / Q000378:metabolism*; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D005215:Fasting; D044089:Galanin-Like Peptide / Q000378:metabolism* / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000294:innervation* / Q000378:metabolism*; D008297:Male; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D044089:Galanin-Like Peptide; D012333:RNA, Messenger