title: Sensory Gating Capacity and Attentional Function in Adults With ADHD: A Preliminary Neurophysiological and Neuropsychological Study.
abstract: Objective:The inability to filter sensory input correctly may impair higher cognitive function in ADHD. However, this relationship remains largely elusive. The objectives of the present study is to investigate the relationship between sensory input processing and cognitive function in adult patients with ADHD.Method:This study investigated the relationship between deficit in sensory gating capacity (P50 amplitude changes in a double-click conditioning-testing paradigm and perceptual abnormalities related to sensory gating deficit with the Sensory Gating Inventory [SGI]) and attentional and executive function (P300 amplitude in an oddball paradigm and attentional and executive performances with a neuropsychological test) in 24 adult patients with ADHD.Results:The lower the sensory gating capacity of the brain and the higher the distractibility related to sensory gating inability that the patients reported, the lower the P300 amplitude.Conclusion:The capacity of the brain to gate the response to irrelevant incoming sensory input may be a fundamental protective mechanism that prevents the flooding of higher brain structures with irrelevant information in adult patients with ADHD.
authors.affiliation: 1 Clinique du sommeil, CHU de Bordeaux, France.|2 USR CNRS 3113 SANPSY / Université de Bordeaux, France.
authors.forename: Jean-Arthur
authors.initials: JA
authors.lastname: Micoulaud-Franchi
authors.affiliation: 3 Unités des troubles du sommeil, Hôpital Gui-de-Chauliac Montpellier, France.|4 Inserm U1061, Montpellier, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Lopez
authors.affiliation: 5 Département de Psychiatrie, CHU de Marseille, France.|6 UMR CNRS 729 / Aix-Marseille Université, Marseille, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Cermolacce
authors.affiliation: 5 Département de Psychiatrie, CHU de Marseille, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Vaillant
authors.affiliation: 5 Département de Psychiatrie, CHU de Marseille, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Péri
authors.affiliation: 5 Département de Psychiatrie, CHU de Marseille, France.|7 EA 3279 / Aix-Marseille Université, Marseille, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Boyer
authors.affiliation: 5 Département de Psychiatrie, CHU de Marseille, France.|7 EA 3279 / Aix-Marseille Université, Marseille, France.
authors.forename: Raphaëlle
authors.initials: R
authors.lastname: Richieri
authors.affiliation: 2 USR CNRS 3113 SANPSY / Université de Bordeaux, France.|8 Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Bordeaux, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Bioulac
authors.affiliation: 2 USR CNRS 3113 SANPSY / Université de Bordeaux, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Sagaspe
authors.affiliation: 1 Clinique du sommeil, CHU de Bordeaux, France.|2 USR CNRS 3113 SANPSY / Université de Bordeaux, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Philip
authors.affiliation: 5 Département de Psychiatrie, CHU de Marseille, France.|6 UMR CNRS 729 / Aix-Marseille Université, Marseille, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Vion-Dury
authors.affiliation: 5 Département de Psychiatrie, CHU de Marseille, France.|7 EA 3279 / Aix-Marseille Université, Marseille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Lancon
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity; D004569:Electroencephalography; D006801:Humans; D009483:Neuropsychological Tests; D012559:Schizophrenia; D055139:Sensory Gating
keywords: ADHD; P300; P50 suppression; adult; attentional function; sensory gating