title: Efficacy and persistent activity of moxidectin against natural Muellerius capillaris infection in goats and pathological consequences of muelleriosis.
abstract: The effect of moxidectin against natural Muellerius capillaris infection in goats was evaluated in this study. Long-acting moxidectin at a single dose of 1 mg kg(-1) body weight was administered to an entire flock (n=10) of goats. The individual faecal larval count reduction was applied as an indicator of treatment efficacy. A significant reduction (>98%) in larval counts was observed in all surveyed animals 14 days after drug administration. Moxidectin demonstrated persistent activity in this study; the mean faecal larval count reduction was 99.1% ± 1.8 on day 77 of the treatment. Macroscopic abnormalities and histological changes in the lungs of two infected goats were evident during the post-mortem examination. The pathological consequences of M. capillaris infection were observed even three months after parasite elimination. The results of this study indicate that moxidectin is a highly effective anthelmintic agent for the control of muelleriosis in goats. This drug provides animals with fifteen weeks of protections against M. capillaris reinfection.
authors.affiliation: Department of Zoology and Fisheries, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 957, 165 21 Prague 6-Suchdol, Czech Republic. Electronic address: vadlejch@af.czu.cz.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Vadlejch
authors.affiliation: Department of Biology, Pedagogical Faculty, Selye János University, Bratislavska 3322, 945 01 Komarno, Slovak Republic.
authors.forename: Pavol
authors.initials: P
authors.lastname: Makovický
authors.affiliation: Department of Zoology and Fisheries, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 957, 165 21 Prague 6-Suchdol, Czech Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Čadková
authors.affiliation: Department of Zoology and Fisheries, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 957, 165 21 Prague 6-Suchdol, Czech Republic.
authors.forename: Iva
authors.initials: I
authors.lastname: Langrová
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D005243:Feces / Q000469:parasitology; D015511:Goat Diseases / Q000188:drug therapy* / Q000473:pathology; D006041:Goats; D007814:Larva; D008168:Lung / Q000473:pathology; D018942:Macrolides / Q000627:therapeutic use*; D008681:Metastrongyloidea / Q000502:physiology; D009349:Nematode Infections / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D059208:Parasite Load / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D018942:Macrolides; C027837:moxidectin
keywords: Goat; Moxidectin; Muellerius capillaris; Pathology