title: Islet Cell Tumors of the Pancreas.
abstract: Islet cell tumors of the pancreas, also known as pancreatic neuroendocrine tumors, constitute less than 5% of pancreatic tumors, and 7% of all neuroendocrine tumors. Most are non-functional, and patients often present with metastatic disease. Functional tumors present with distinct clinical syndromes. Accurate staging is critical as surgery is both the cornerstone of treatment, and the only hope for cure. Medical management involves treating the manifestations of hormonal excess, and using somatastatin analogues when appropriate. Systemic chemotherapy, targeted molecular therapy, and peptide receptor radiotherapy may be used for refractory disease in lieu of or as an adjunct to surgery.
authors.affiliation: Division of Gastroenterology, Department of Medicine Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1069, New York, NY 10029, USA.
authors.forename: Sunil
authors.initials: S
authors.lastname: Amin
authors.affiliation: Division of Gastroenterology, Department of Medicine Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1069, New York, NY 10029, USA. Electronic address: Michelle.Kim@mountsinai.org.
authors.forename: Michelle Kang
authors.initials: MK
authors.lastname: Kim
mesh_terms: D007516:Adenoma, Islet Cell / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D019160:Endosonography; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D058990:Molecular Targeted Therapy; D018761:Multiple Endocrine Neoplasia Type 1; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy*; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D016577:Pancreaticoduodenectomy; D049268:Positron-Emission Tomography; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin; D013004:Somatostatin / Q000031:analogs & derivatives; D014057:Tomography, X-Ray Computed; D006623:von Hippel-Lindau Disease
chemical_list: D006728:Hormones; D017481:Receptors, Somatostatin; D013004:Somatostatin
keywords: Islet cell tumor; Pancreas; Pancreas cancer; Pancreatic neuroendocrine tumors (PNET); Targeted molecular therapy