title: A case of congenital prothrombin deficiency and idiopathic thrombocytopenic purpura in a pregnant female.
abstract: Hereditary prothrombin deficiency is an autosomal recessive disorder with an estimated incidence of 1 in 2 million . Presentation of the disease is variable; however, it is usually associated with moderate to severe bleeding tendencies including muscle hematomas, hemarthrosis, intracranial, mucosal, and postoperative bleeding. Here we report a case of a 35-year-old pregnant woman with congenital hypoprothrombinemia and idiopathic thrombocytopenic purpura, review the literature, and discuss its epidemiology, presentation, diagnosis, and treatment.
authors.affiliation: Hematology/Oncology Faculty, NSLIJ/Lenox Hill Hospital, New York, USA.
authors.forename: Ronen
authors.initials: R
authors.lastname: Harel
authors.forename: Dana
authors.initials: D
authors.lastname: Shani
authors.forename: Kelsey
authors.initials: K
authors.lastname: Donohoe
mesh_terms: D000328:Adult; D005260:Female; D006474:Hemorrhagic Disorders / Q000150:complications*; D006801:Humans; D007020:Hypoprothrombinemias / Q000150:complications*; D011247:Pregnancy; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*