title: Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver.
abstract: This study investigated the effect of tucum-do-cerrado consumption in the oxidative status of iron-supplemented rats. Four groups of rats were treated: Control (AIN-93G), Tuc (AIN-93G added of tucum-do-cerrado), Fe (AIN-93G iron-enriched), or TucFe (AIN-93G with tucum-do-cerrado and iron-enriched) diet, for 30 days. Iron-enriched diet increased serum, liver, spleen, and intestine iron levels; transferrin saturation; liver lipid oxidation; mRNA levels of hepatic Hamp and Bmp6, and Nrf2 in the intestine. Tucum-do-cerrado consumption reduced spleen lipid and protein oxidation; mRNA levels of hepatic Hamp and Ftl, and increased serum antioxidant capacity and hepatic mRNA levels of Bmp6, Hmox1, Nqo1, and Nrf2. TucFe diet consumption abrogated the liver Hamp iron-induced up-regulation, prevented intestinal iron accumulation; hepatic lipid peroxidation; splenic protein damage, and the increase of catalase, glutathione reductase, and glutathione peroxidase activity in some tissues. These results suggest that tucum-do-cerrado protects tissues against oxidative damage, by reducing iron availability in liver and consequently inhibiting liver Hamp expression.
authors.affiliation: Department of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, Brazil. adriana.fustinoni3@gmail.com.
authors.forename: Adriana M
authors.initials: AM
authors.lastname: Fustinoni-Reis
authors.affiliation: Department of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, Brazil. sandrafarruda@gmail.com.
authors.forename: Sandra F
authors.initials: SF
authors.lastname: Arruda
authors.affiliation: Department of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, Brazil. liviapsdourado@gmail.com.
authors.forename: Lívia P S
authors.initials: LP
authors.lastname: Dourado
authors.affiliation: Department of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, Brazil. desa.marcela@gmail.com.
authors.forename: Marcela S B
authors.initials: MS
authors.lastname: da Cunha
authors.affiliation: Department of Cell Biology, Biological Sciences Institute, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, Brazil. eglemasi@gmail.com.
authors.forename: Egle M A
authors.initials: EM
authors.lastname: Siqueira
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D028023:Arecaceae; D002374:Catalase / Q000378:metabolism; D004032:Diet; D005527:Food, Fortified; D005978:Glutathione / Q000378:metabolism; D064451:Hepcidins / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D007501:Iron / Q000097:blood / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D050050:Protein Carbonylation / Q000187:drug effects; D012333:RNA, Messenger / Q000378:metabolism; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D000975:Antioxidants; C578703:Hamp protein, rat; D064451:Hepcidins; D010936:Plant Extracts; D012333:RNA, Messenger; D007501:Iron; D002374:Catalase; D005978:Glutathione
keywords: Hamp; Nfr2; oxidative stress; tucum-do-cerrado (Bactris setosa Mart.)