title: Histoplasmosis.
abstract: Although histoplasmosis is highly endemic in certain regions of the Americas, disease may be seen globally and should not be overlooked in patients with unexplained pulmonary or systemic illnesses. Most patients exhibit pulmonary signs and symptoms, accompanied by radiographic abnormalities, which often are mistaken for community-acquired pneumonia caused by bacterial or viral agents. Once a diagnosis is considered, a panel of mycologic and non-culture-based assays is adequate to establish a diagnosis in a few days to a week in most patients. Once diagnosed, the treatment is highly effective even in immunocompromised patients.
authors.affiliation: MiraVista Diagnostics, 4705 Decatur Boulevard, Indianapolis, IN 46241, USA. Electronic address: jwheat@miravistalabs.com.
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Wheat
authors.affiliation: Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Marwan M
authors.initials: MM
authors.lastname: Azar
authors.affiliation: Division of Infectious Diseases, University of Kansas, 3901 Rainbow Boulevard, Mailstop 1028, Kansas City, KS 66160, USA.
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Bahr
authors.affiliation: Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, Saint Louis, MO 63110, USA.
authors.forename: Andrej
authors.initials: A
authors.lastname: Spec
authors.affiliation: Division of Clinical Microbiology, Department of Pathology and Laboratory Medicine, IU Health Pathology Laboratory, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA.
authors.forename: Ryan F
authors.initials: RF
authors.lastname: Relich
authors.affiliation: Methodist Professional Center-1, Suite 230, 1801 N Senate Boulevard, Indianapolis, IN 46202, USA.
authors.forename: Chadi
authors.initials: C
authors.lastname: Hage
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host
chemical_list: D000935:Antifungal Agents
keywords: Antibody; Antigen; Central nervous system; Disseminated; Histoplasma; Histoplasmosis; Pulmonary; Serology