title: Benefits of the Nephros Dual Stage Ultrafilter in Chronic Hemodialysis Patients: Evidence for Improved ESA Responsiveness.
abstract: Installation of the Nephros Dual Stage Ultrafilter (DSU) added to a conventional hemodialysis unit to achieve ultrapure dialysate was tested in a group of 23 stable outpatients on chronic hemodialysis. Comparing the 6-month period prior to the installation of the filters (as baseline) to the 6-month period after the installation of the filters, we found a significant 40% reduction in the darbepoetin dose needed to maintain a stable hemoglobin level (p < 0.001). In addition, surrogate inflammatory markers, WBC count and serum albumin level, showed small but statistically significant improvements (p = 0.008 and p = 0.042, respectively). In conclusion, the use of the Nephros DSU to further reduce endotoxin exposure in chronic hemodialysis patients can result in improved erythropoiesis-stimulating agent (ESA) responsiveness and a lower ESA dose.
authors.affiliation: Department of Medicine, New York-Presbyterian Hospital/Columbia University Medical Center, New York, N.Y., USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Valeri
authors.affiliation: Department of Pharmacy, New York-Presbyterian Hospital/Columbia University Medical Center, New York, N.Y., USA.
authors.forename: Bobby
authors.initials: B
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, New York-Presbyterian Hospital/Columbia University Medical Center, New York, N.Y., USA.
authors.forename: John
authors.initials: J
authors.lastname: Duffy
authors.affiliation: Department of Nursing, New York-Presbyterian Hospital/Columbia University Medical Center, New York, N.Y., USA.
authors.forename: Robin
authors.initials: R
authors.lastname: Ferrer
authors.affiliation: Department of Nursing, New York-Presbyterian Hospital/Columbia University Medical Center, New York, N.Y., USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Vilotta
keywords: Dual Stage Ultrafilter; ESA; Erythropoiesis-stimulating agent; Hemodialysis