title: Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers.
abstract: Nasopharyngeal carcinoma-associated gene 6 (NGX6) is a membrane protein primarily located in the nuclear membrane and cell membrane. Several groups reported that NGX6 gene was down-regulated in nasopharyngeal carcinoma (NPC), gastric cancer, lung cancer, liver cancer, and colorectal cancer and even less in the carcinomas with metastasis. Current studies have demonstrated that NGX6 possesses various biological functions, such as regulating protein expression of related genes, involving cell signal transduction pathways, negatively controlling cell cycle progression, inhibiting angiogenesis, and increasing the sensitivity of patients to anti-cancer drugs. Some factors regulating the expression level of NGX6 gene also have been studied. The methylation of promoter of NGX6 and histone H3K9 negatively regulates its expression, similar to the function of transcription factor special protein-1 (Sp1). However, the regulatory factor early growth response gene 1 (Egr-1) is provided with positive regulation function. This review will summarize the progress of those studies on NGX6 and elucidate the potential application of NGX6 for some malignant diseases.
authors.affiliation: Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China.|Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, China.
authors.forename: Shiwei
authors.initials: S
authors.lastname: He
authors.affiliation: Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China.|Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, China.
authors.forename: Yancheng
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Orthopedic Biomedical Materials Institute, Central South University, Changsha, 410083, China.
authors.forename: Cijun
authors.initials: C
authors.lastname: Shuai
authors.affiliation: Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China.|Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Gao
authors.affiliation: Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China.|Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, China.
authors.forename: Pingpin
authors.initials: P
authors.lastname: Wei
authors.affiliation: Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China.|Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, China.
authors.forename: Guiyuan
authors.initials: G
authors.lastname: Li
authors.affiliation: Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China. shuping@csu.edu.cn.|Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, China. shuping@csu.edu.cn.
authors.forename: Shuping
authors.initials: S
authors.lastname: Peng
mesh_terms: D002453:Cell Cycle; D019175:DNA Methylation; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D051766:Early Growth Response Protein 1 / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D042421:Histone Code; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: C497325:EGR1 protein, human; D051766:Early Growth Response Protein 1; D008565:Membrane Proteins; C477325:TMEM8B protein, human; D025521:Tumor Suppressor Proteins
keywords: Growth; Metastasis; NGX6; Tumor suppressor