title: Association of risk of non-Hodgkin's lymphoma with hepatitis B virus infection: a meta-analysis.
abstract: OBJECTIVE
  A meta-analysis was carried out to systematically evaluate the correlation between hepatitis B virus (hepatitis B virus, HBV) infection and risk of non-Hodgkin's lymphoma (non-Hodgkin lymphoma, NHL).
  
  
  METHODS
  We searched Medline, EMBASE, PubMed, Cochrane Library, Chinese Biomedical Literature Database, Chinese Journal Full-text Database, Chinese scientific journals full text databases and collected information about HBV infection and risk of NHL associated case-control studies. Two reviewers extracted useful information which were included in the study independently, and Revman 5.2 was used for meta-analysis.
  
  
  RESULTS
  A total of 24 studies were included in this research. Meta-analysis showed that among all of the included studies the heterogeneity were existed (I(2) = 76%, P<0.05). With random effects model the OR was 2.39 (95% CI, 1.93-3.96), indicating infection rate in NHL patients with HBV was higher than that in the control group. Subgroup analysis according to ethnicity suggested that HBV infection were associated with NHL risk both in Asian (OR = 2.46, 95% CI: 2.01, 3.00, P<0.001) and Caucasian (OR = 2.15, 95% CI: 1.37, 3.37, P<0.001) population.
  
  
  CONCLUSIONS
  HBV infection may increase the risk of NHL, but it still need a large number of experiments and epidemiological studies to verify.
authors.affiliation: Department of Hematolopy, No. 4 Centyal Hospital of Tianjin Tianjin 300140, China.
authors.forename: Zhenjia
authors.initials: Z
authors.lastname: Qi
authors.affiliation: Department of Hematology, Xi'an Central Hospital 710003, Shanxi, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Hematology, Xijing Hospital, Fourth Military Medical University Xi'an 710032, Shaanxi, China.
authors.forename: Guangxun
authors.initials: G
authors.lastname: Gao
keywords: Hepatitis B virus; Non-Hodgkin’s lymphoma; meta-analysis; risk