title: [Relationship between hyperhomocysteine and long-term outcome of coronary artery disease patients after drug-eluting stent implantation].
abstract: OBJECTIVE
  To explore the relationship between hyperhomocysteinemia (H-Hcy) and long-term outcome of coronary artery disease (CAD) patients after drug-eluting stent (DES) implantation in a single centre.
  
  
  METHODS
  A total of 1 408 consecutive patients implanted with DES in our department between March 2011 and January 2013 were enrolled in this prospective study. Patients were stratified into H-Hcy (Hcy≥10 µmol/L, n=798, 56.7%) and non-H-Hcy group (Hcy<10 µmol/L, n=610, 43.3%). The clinical characteristics, coronary artery lesions, SYNTAX score and 1-year major adverse cardiac and cerebrovascular events (MACCE) were compared between the two groups.
  
  
  RESULTS
  Compared with non-H-Hcy group, coronary artery stenosis was severer as shown by higher diseased arteries (2.11±0.87 vs. 1.91±0.82, P<0.001), higher incidence of three diseased arteries (39.7% vs. 29.5%, P<0.001) and higher SYNTAX score (36.99±29.66 vs. 27.39±22.70, P=0.001) in H-Hcy group. The 1-year incidence of MACCE was also higher in H-Hcy group compared with non-H-Hcy group(18.4% vs. 8.9%, P<0.001). Multivariate Cox analysis showed that diabetes mellitus (OR=1.530, 95%CI 1.142-2.050, P=0.004), age (OR=1.065, 95%CI 1.038-1.093; P<0.001), and Hcy (OR=1.019, 95%CI 1.005-1.033, P=0.009) are the independent predictors for 1-year MACCE.
  
  
  CONCLUSIONS
  High Hcy level is correlated with the severity of coronary artery stenosis, and serves as an independent predictor of MACCE after stenting in CAD patients.
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Gaoliang
authors.initials: G
authors.lastname: Yan
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Kong
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Sha
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Tianyu
authors.initials: T
authors.lastname: Cheng
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Jiantong
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China; Email: tangchengchun@medmail.com.cn.
authors.forename: Chengchun
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Genshan
authors.initials: G
authors.lastname: Ma
mesh_terms: D003324:Coronary Artery Disease; D054855:Drug-Eluting Stents; D006710:Homocysteine; D006801:Humans; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D006710:Homocysteine