title: Acidity-Activated Shielding Strategies of Cationic Gene Delivery for Cancer Therapy.
abstract: Cationic gene vectors increased attractive for gene therapy. However, unstable systemic circulation due to the interaction of gene delivery system with blood cells limited the further application. Therefore, pH sensitive shielding systems were exploited, by which, the positive surface charge density of polyplexes was reduced, circulation time was improved and pH-triggered targeting delivery was promised. This mini review mainly focuses on the development of solid tumors pH environment activated shielding systems for cationic gene vectors. This shielding strategy shows great potential for enhancing efficient gene transporting and achieving better therapeutic effects in acidic tumor treatment.
authors.affiliation: School of Chemistry and Chemical Engineering, Lingnan Normal University, 29 Cunjin Road, Zhanjiang, Guangdong 524048, PR China. xiajl105@126.com.
authors.forename: Jialiang
authors.initials: J
authors.lastname: Xia
authors.forename: Zongcai
authors.initials: Z
authors.lastname: Feng
authors.forename: Hongyan
authors.initials: H
authors.lastname: Yang
authors.forename: Sanqing
authors.initials: S
authors.lastname: Lin
authors.forename: Bing
authors.initials: B
authors.lastname: Han
mesh_terms: D002412:Cations / Q000737:chemistry; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*
chemical_list: D002412:Cations