title: Experimental Models of Vaginal Candidiasis and Their Relevance to Human Candidiasis.
abstract: Vulvovaginal candidiasis (VVC) is a high-incidence disease seriously affecting the quality of life of women worldwide, particularly in its chronic, recurrent forms (RVVC), and with no definitive cure or preventive measure. Experimental studies in currently used rat and mouse models of vaginal candidiasis have generated a large mass of data on pathogenicity determinants and inflammation and immune responses of potential importance for the control of human pathology. However, reflection is necessary about the relevance of these rodent models to RVVC. Here we examine the chemical, biochemical, and biological factors that determine or contrast the forms of the disease in rodent models and in women and highlight the differences between them. We also appeal for approaches to improve or replace the current models in order to enhance their relevance to human infection.
authors.affiliation: Polo d'innovazione della genomica, genetica e biologia, Università di Perugia, Perugia, Italy a.cassone@pologgb.com.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cassone
authors.affiliation: Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA.
authors.forename: Jack D
authors.initials: JD
authors.lastname: Sobel
mesh_terms: D000818:Animals; D002175:Candida / Q000472:pathogenicity*; D002181:Candidiasis, Vulvovaginal / Q000382:microbiology* / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D051379:Mice; D051381:Rats