title: Basic Genetics and Immunology of Candida Infections.
abstract: Candida infections can cause superficial and invasive disease. Several essential mechanisms underlying the pathogenesis of these infections were known for some time, such as neutropenia predisposing to invasive disease, and CD4 lymphopenia causing increased susceptibility to mucosal candidiasis. However, the development of novel genetic screening techniques has led to several new insights in the genetics and immunology of candida infections. This article highlights novel insights in the pathogenesis of mucocutaneous and invasive candidiasis that have been identified in recent years.
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, Nijmegen, 6525 GA, The Netherlands; Department of Dermatology, Peking University First Hospital, Xishiku Street 8, Xicheng District, Beijing 10034, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, Nijmegen, 6525 GA, The Netherlands; Radboud Center for Infectious Diseases (RCI), Geert Grooteplein Zuid 8, Nijmegen, 6525 GA, The Netherlands.
authors.forename: Frank L
authors.initials: FL
authors.lastname: van de Veerdonk
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, Nijmegen, 6525 GA, The Netherlands; Radboud Center for Infectious Diseases (RCI), Geert Grooteplein Zuid 8, Nijmegen, 6525 GA, The Netherlands. Electronic address: mihai.netea@radboudumc.nl.
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
mesh_terms: D002175:Candida / Q000235:genetics / Q000276:immunology; D002177:Candidiasis / Q000235:genetics* / Q000276:immunology*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans
keywords: Candida; Candidiasis; Genetics; Immunology