title: [Acupuncture Intervention Reduced Weight Gain Induced by Hypoglycemic Agents through Food Intake-related Targets in Central Nervous System].
abstract: Clinical practice shows that thiazolidinediones (TZDs) induce weight gain in patients with type-II diabetes mellitus during treatment, which restrains its application and generalization clinically. It has been demonstrated that acupuncture therapy is useful in easing obesity in clinical trials. In the present paper, we summarize the underlying mechanism of weight gain induced by TZDs through food intake-related targets in the central nervous system and analyze the possible effects of acupuncture therapy. Acupuncture therapy is expected to reduce weight gain side effect of TZDs through 1) lowering permeability of blood brain barrier to reduce TZDs concentration in the brain, 2) upregulating the expression of hypothalamic leptin and inhibiting hypothalamic neuropiptide Y expression, and 3) down-regulating activities of peroxisome proliferator-activated receptor to reduce energy intake and fat syntheses.
authors.forename: Xin-yue
authors.initials: XY
authors.lastname: Jing
authors.forename: Chen
authors.initials: C
authors.lastname: Ou
authors.forename: Sheng-feng
authors.initials: SF
authors.lastname: Lu
authors.forename: Bing-mei
authors.initials: BM
authors.lastname: Zhu
mesh_terms: D015670:Acupuncture Therapy; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D004435:Eating; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D020738:Leptin / Q000235:genetics / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics / Q000378:metabolism; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000009:adverse effects*; D015430:Weight Gain
chemical_list: D007004:Hypoglycemic Agents; D020738:Leptin; D047492:Peroxisome Proliferator-Activated Receptors; D045162:Thiazolidinediones