title: The potential role of CacyBP/SIP in tumorigenesis.
abstract: Calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) was initially described as a binding partner of S100A6 in the Ehrlich ascites tumor cells and later as a Siah-1-interacting protein. This 30 kDa protein includes three domains and is involved in cell proliferation, differentiation, cytoskeletal rearrangement, and transcriptional regulation via binding to various proteins. Studies have also shown that the CacyBP/SIP is a critical protein in tumorigenesis. But, its promotion or suppression of cancer progression may depend on the cell type. In this review, the biological characteristics and target proteins of CacyBP/SIP have been described. Moreover, the exact role of CacyBP/SIP in various cancers is discussed.
authors.affiliation: Department of Geriatrics, Xi Jing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. ningxx01@fmmu.edu.cn.
authors.forename: Xiaoxuan
authors.initials: X
authors.lastname: Ning
authors.affiliation: Department of Geriatrics, Xi Jing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Geriatrics, Xi Jing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
authors.forename: Xiaosu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Geriatrics, Xi Jing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
authors.forename: Qiaoneng
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Nephrology, Xi Jing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. ningsun@fmmu.edu.cn.
authors.forename: Shiren
authors.initials: S
authors.lastname: Sun
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000502:physiology*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D003598:Cytoskeletal Proteins / Q000378:metabolism; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism
chemical_list: C491778:CACYBP protein, human; C111922:Cacybp protein, mouse; D002135:Calcium-Binding Proteins; D003598:Cytoskeletal Proteins; D009363:Neoplasm Proteins; D009418:S100 Proteins; D051176:beta Catenin; D043743:Ubiquitin-Protein Ligase Complexes; D048049:Extracellular Signal-Regulated MAP Kinases
keywords: CacyBP/SIP; Multidrug resistance; Tumorigenesis; β-Catenin