title: Perfusion information extracted from resting state functional magnetic resonance imaging.
abstract: It is widely known that blood oxygenation level dependent (BOLD) contrast in functional magnetic resonance imaging (fMRI) is an indirect measure for neuronal activations through neurovascular coupling. The BOLD signal is also influenced by many non-neuronal physiological fluctuations. In previous resting state (RS) fMRI studies, we have identified a moving systemic low frequency oscillation (sLFO) in BOLD signal and were able to track its passage through the brain. We hypothesized that this seemingly intrinsic signal moves with the blood, and therefore, its dynamic patterns represent cerebral blood flow. In this study, we tested this hypothesis by performing Dynamic Susceptibility Contrast (DSC) MRI scans (i.e. bolus tracking) following the RS scans on eight healthy subjects. The dynamic patterns of sLFO derived from RS data were compared with the bolus flow visually and quantitatively. We found that the flow of sLFO derived from RS fMRI does to a large extent represent the blood flow measured with DSC. The small differences, we hypothesize, are largely due to the difference between the methods in their sensitivity to different vessel types. We conclude that the flow of sLFO in RS visualized by our time delay method represents the blood flow in the capillaries and veins in the brain.
authors.affiliation: 1 McLean Imaging Center, McLean Hospital, Belmont, MA, USA.|2 Department of Psychiatry, Harvard University Medical School, Boston, MA, USA.
authors.forename: Yunjie
authors.initials: Y
authors.lastname: Tong
authors.affiliation: 1 McLean Imaging Center, McLean Hospital, Belmont, MA, USA.|2 Department of Psychiatry, Harvard University Medical School, Boston, MA, USA.
authors.forename: Kimberly P
authors.initials: KP
authors.lastname: Lindsey
authors.affiliation: 1 McLean Imaging Center, McLean Hospital, Belmont, MA, USA.|3 Department of Radiology, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Lia M
authors.initials: LM
authors.lastname: Hocke
authors.affiliation: 1 McLean Imaging Center, McLean Hospital, Belmont, MA, USA.|2 Department of Psychiatry, Harvard University Medical School, Boston, MA, USA.
authors.forename: Gordana
authors.initials: G
authors.lastname: Vitaliano
authors.affiliation: 1 McLean Imaging Center, McLean Hospital, Belmont, MA, USA.|2 Department of Psychiatry, Harvard University Medical School, Boston, MA, USA.
authors.forename: Dionyssios
authors.initials: D
authors.lastname: Mintzopoulos
authors.affiliation: 1 McLean Imaging Center, McLean Hospital, Belmont, MA, USA.|2 Department of Psychiatry, Harvard University Medical School, Boston, MA, USA.
authors.forename: Blaise deB
authors.initials: BD
authors.lastname: Frederick
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping / Q000379:methods; D002560:Cerebrovascular Circulation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010477:Perfusion / Q000379:methods
chemical_list: D010100:Oxygen
keywords: Blood oxygenation level dependent contrast; cerebral blood flow; cerebral blood flow measurement; functional magnetic resonance imaging; perfusion weighted magnetic resonance imaging