title: ST-segment abnormalities are associated with long-term prognosis in non-ST-segment elevation acute coronary syndromes: The ERICO-ECG study.
abstract: We aimed to identify whether ST-segment abnormalities, in the admission or during in-hospital stay, are associated with survival and/or new incident myocardial infarction (MI) in 623 non-ST-elevation acute coronary syndrome participants of the Strategy of Registry of Acute Coronary Syndrome (ERICO) study.
  
  
  
  ERICO is conducted in a community-based hospital. ST-segment analysis was based on the Minnesota Code. We built Cox regression models to study whether ECG was an independent predictor for clinical outcomes.
  
  
  
  Median follow-up was 3years. We found higher risk of death due to MI in individuals with ST-segment abnormalities in the final ECG (adjusted hazard ratio: 2.68; 95% confidence interval: 1.14-6.28). Individuals with ST-segment abnormalities in any tracing had a non-significant trend toward a higher risk of fatal or new non-fatal MI (p=0.088).
  
  
  
  ST-segment abnormalities after the initial tracing added long-term prognostic information.
authors.affiliation: Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil.
authors.forename: Rodrigo M
authors.initials: RM
authors.lastname: Brandão
authors.affiliation: Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil.
authors.forename: Nelson
authors.initials: N
authors.lastname: Samesima
authors.affiliation: Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Pastore
authors.affiliation: Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil.
authors.forename: Henrique L
authors.initials: HL
authors.lastname: Staniak
authors.affiliation: Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil; Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo, Brazil.
authors.forename: Paulo A
authors.initials: PA
authors.lastname: Lotufo
authors.affiliation: Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil; Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo, Brazil.
authors.forename: Isabela M
authors.initials: IM
authors.lastname: Bensenor
authors.affiliation: Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil.
authors.forename: Alessandra C
authors.initials: AC
authors.lastname: Goulart
authors.affiliation: Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil; Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo, Brazil. Electronic address: itamarss@usp.br.
authors.forename: Itamar S
authors.initials: IS
authors.lastname: Santos
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D000368:Aged; D000465:Algorithms; D001938:Brazil / Q000453:epidemiology; D015331:Cohort Studies; D015897:Comorbidity; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004562:Electrocardiography / Q000379:methods* / Q000706:statistics & numerical data*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D000072658:Non-ST Elevated Myocardial Infarction / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D015995:Prevalence; D011379:Prognosis; D016016:Proportional Hazards Models; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D016019:Survival Analysis
keywords: Cohort; Coronary heart disease; Electrocardiography; Prognosis