title: Clinical Severity and Rotavirus Vaccination among Children Hospitalized for Acute Gastroenteritis in Belém, Northern Brazil.
abstract: In March 2006, Brazil introduced the monovalent rotavirus (RV) vaccine (Rotarix™) into the public sector. This study assessed the severity of rotavirus gastroenteritis (RVGE) according to the vaccination status among hospitalized children. We identified 1023 RVGE episodes among not vaccinated (n = 252), partially vaccinated (n = 156) and fully vaccinated (n = 615) children. Very severe gastroenteritis (scored ≥ 15) was reported in 16.7, 17.9 and 13.5% of not vaccinated, partially vaccinated and fully vaccinated children, respectively. There was a trend for a shorter duration of RV diarrhoea among vaccinated children than in not vaccinated children (p = 0.07). A protective effect of vaccination was noted when mean duration of symptoms and hospital stay are analysed, comparing unvaccinated, partially vaccinated and fully vaccinated children (p < 0.05). We showed a vaccination dose effect trend, with fully vaccinated children having less-severe RVGE than not vaccinated and partially vaccinated children.
authors.affiliation: Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua, Pará, Brazil.
authors.forename: Maria Cleonice A
authors.initials: MC
authors.lastname: Justino
authors.affiliation: Instituto de Pesquisa Clínica, Fundação Oswaldo Cruz, 21.040-900 Rio de Janeiro, Brazil.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Brasil
authors.affiliation: Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua, Pará, Brazil.
authors.forename: Erika
authors.initials: E
authors.lastname: Abreu
authors.affiliation: Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua, Pará, Brazil.
authors.forename: Yllen
authors.initials: Y
authors.lastname: Miranda
authors.affiliation: Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua, Pará, Brazil.
authors.forename: Joana D'Arc P
authors.initials: JD
authors.lastname: Mascarenhas
authors.affiliation: Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua, Pará, Brazil.
authors.forename: Sylvia F S
authors.initials: SF
authors.lastname: Guerra
authors.affiliation: Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua, Pará, Brazil alexandrelinhares@iec.pa.gov.br.
authors.forename: Alexandre C
authors.initials: AC
authors.lastname: Linhares
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D006801:Humans; D017589:Immunization Programs; D015994:Incidence; D008297:Male; D011159:Population Surveillance; D011446:Prospective Studies; D012401:Rotavirus / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000453:epidemiology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology; D012720:Severity of Illness Index; D014611:Vaccination / Q000706:statistics & numerical data*
chemical_list: D022243:Rotavirus Vaccines
keywords: gastroenteritis; rotavirus; severity; vaccination status