title: Glandular epithelial abnormalities on thinprep® pap tests: Clinical and cytohistologic correlation.
abstract: BACKGROUND
  Although the incidence of glandular epithelial abnormalities on cervical cytology is low, the clinical and histologic findings are often significant. The laboratory's 12-year experience is reported.
  
  
  METHODS
  from January 1, 2003 to December 31, 2014, the Cytopathology Laboratory of the University of Wisconsin Hospital and Clinics processed 191,087 ThinPrep(®) Pap Tests of which 184 (0.1%) were reported as glandular epithelial abnormalities. One hundred forty-three (78%) of these cases had histologic follow-up and form the basis of this study. Of the 143 women (mean age, 52; median, 50), 45% presented with vaginal bleeding and 55% were asymptomatic. The cytologic groups included atypical glandular cells, atypical glandular cells; favor a neoplastic process, atypical endocervical cells, atypical endocervical cells; favor a neoplastic process, endocervical adenocarcinoma in situ, atypical endometrial cells and adenocarcinoma, NOS.
  
  
  RESULTS
  Overall, the histologic follow-up showed epithelial abnormalities including endometrial and endocervical carcinoma, endocervical adenocarcinoma in situ, CIN 3 involving endocervical glands and metastatic carcinoma in 78% of the cases. The diagnoses were age-dependent and influenced by clinical symptomatology.
  
  
  CONCLUSIONS
  Glandular epithelial abnormalities on Pap tests warrant further clinical investigation.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Selvaggi
mesh_terms: D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology*; D065006:Papanicolaou Test / Q000592:standards / Q000706:statistics & numerical data*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
keywords: ThinPrep® Pap test; clinical findings; cytohistologic correlation; glandular epithelial abnormalities