title: A novel analytical ultracentrifugation based approach to the low resolution structure of gum arabic.
abstract: Under investigation are the structural properties of gum arabic, an industrially important biopolymer for use as a stabilizer or in drug delivery, using Analytical Ultracentrifugation-a well-established, matrix-free probe for macromolecular size and shape. These results are combined with chromatographically-coupled methods (multi-angle light scattering, differential press imbalance viscometry) to provide a global analysis of its structure in varying ionic strength conditions. This analysis indicates that gum Arabic may have a compact, elliptical structure in solution, the significance of which for biotechnological use is indicated. This modelling method can be applied to other biopolymers and synthetic polymers. © 2016 Wiley Periodicals, Inc. Biopolymers 105: 618-625, 2016.
authors.affiliation: University of Nottingham, Faculty of Medicine and Health Science, School of Health Sciences, Queens Medical Centre, NG7 2RD, UK.|University of Nottingham, National Centre for Macromolecular Hydrodynamics, School of Biosciences, Sutton Bonington Campus, Loughborough, LE12 5RD, UK.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Gillis
authors.affiliation: University of Nottingham, Faculty of Medicine and Health Science, School of Health Sciences, Queens Medical Centre, NG7 2RD, UK.|University of Nottingham, National Centre for Macromolecular Hydrodynamics, School of Biosciences, Sutton Bonington Campus, Loughborough, LE12 5RD, UK.
authors.forename: Gary G
authors.initials: GG
authors.lastname: Adams
authors.affiliation: University of Nottingham, Faculty of Medicine and Health Science, School of Health Sciences, Queens Medical Centre, NG7 2RD, UK.|University of Nottingham, National Centre for Macromolecular Hydrodynamics, School of Biosciences, Sutton Bonington Campus, Loughborough, LE12 5RD, UK.
authors.forename: Qushmua
authors.initials: Q
authors.lastname: Alzahrani
authors.affiliation: University of Nottingham, National Centre for Macromolecular Hydrodynamics, School of Biosciences, Sutton Bonington Campus, Loughborough, LE12 5RD, UK.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Harding
mesh_terms: D006170:Gum Arabic / Q000737:chemistry*; D014461:Ultracentrifugation
chemical_list: D006170:Gum Arabic
keywords: AUC; acacia; characterization; conformation; gum arabic; hydrodynamic; sedimentation velocity; ultracentrifugation