title: Accurate Lipophilicity (log P) Measurements Inform on Subtle Stereoelectronic Effects in Fluorine Chemistry.
abstract: Polar exploration: Recently, Linclau and co-workers disclosed a straightforward (19)F-NMR method for determining the log P values of fluorocarbons. The method is particularly useful for most polar compounds and provides a quantitative way to rationalize the more subtle stereoelectronic consequences of fluorine introduction.
authors.affiliation: School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK. do1@st-andrews.ac.uk.
authors.forename: David
authors.initials: D
authors.lastname: O'Hagan
authors.affiliation: Medicinal Chemistry, GlaxoSmithKline R&D, Stevenage, Hertfordshire, SG1 2NY, UK. rob.j.young@gsk.com.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Young
keywords: NMR spectroscopy; fluorine; fluorocarbons; lipophilicity