title: Differences in homeostatic model assessment (HOMA) values and insulin levels after vitamin D supplementation in healthy men: a double-blind randomized controlled trial.
abstract: Vitamin D is thought to play a role in glucose metabolism. The aim of the present study was to determine the effect of vitamin D supplementation on markers of insulin sensitivity and inflammation in men without diabetes with vitamin D deficiency/insufficiency. In this 1-year double-blind randomized controlled trial, 130 men aged 20-65 years (mean age 47.52 ± 11.84 years) with serum 25-hydroxyvitamin D levels <50 nmol/l (mean 38.89 ± 8.64 nmol/l) were randomized to treatment (100 000 IU vitamin D bimonthly) or placebo. Anthropometric measurements, demographic questionnaires, and blood indices (fasting glucose, insulin, high-sensitivity C-reactive protein, lipids) were collected and repeated after 6 and 12 months. The compliance rate was 98.5%. Multivariate models, adjusted for baseline levels, age, body mass index, sun exposure, physical activity and LDL, showed significant differences in insulin and homeostatic model assessment of insulin resistance (HOMA-IR) values between groups. Levels of insulin and HOMA-IR values remained steady during the study period in the treatment group but increased by 16% in the control group (p = 0.038 and p = 0.048, respectively). Vitamin D supplementation administered for 12 months in healthy men maintained insulin levels and HOMA-IR values relative to the increase in the control group. Further studies are needed to establish the long-term effect of vitamin D supplementation on the risk of diabetes.
authors.affiliation: S. Daniel Abraham International Center for Health and Disease, Department of Public Health, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Tepper
authors.affiliation: S. Daniel Abraham International Center for Health and Disease, Department of Public Health, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel.
authors.forename: D R
authors.initials: DR
authors.lastname: Shahar
authors.affiliation: S. Daniel Abraham International Center for Health and Disease, Department of Public Health, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Geva
authors.affiliation: Elisha Medical Center, Department of Endocrinology & Diabetes, Haifa, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Ish-Shalom
mesh_terms: D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000097:blood; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D014807:Vitamin D / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000178:diet therapy*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007328:Insulin; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: clinical trial; dietary intervention; insulin; vitamin D