title: Adoptive Autophagy Activation: a Much-Needed Remedy Against Chemical Induced Neurotoxicity/Developmental Neurotoxicity.
abstract: The profound significance of autophagy as a cell survival mechanism under conditions of metabolic stress is a well-proven fact. Nearly a decade-long research in this area has led scientists to unearth various roles played by autophagy other than just being an auto cell death mechanism. It is implicated as a vital cell survival pathway for clearance of all the aberrant cellular materials in case of cellular injury, metastasis, disease states, cellular stress, neurodegeneration and so on. In this review, we emphasise the critical role of autophagy in the environmental stressors-induced neurotoxicity and its therapeutic implications for the same. We also attempt to shed some light on the possible protective role of autophagy in developmental neurotoxicity (DNT) which is a rapidly growing health issue of the human population at large and hence a point of rising concern amongst researchers. The intimate association between DNT and neurodegenerative disorders strongly indicates towards adopting autophagy activation as a much-needed remedy for DNT.
authors.affiliation: System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India.|BBD College of Dental Sciences, BBD University, Faizabad Road, Lucknow, Uttar Pradesh, 227015, India.
authors.forename: A
authors.initials: A
authors.lastname: Srivastava
authors.affiliation: System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India.
authors.forename: V
authors.initials: V
authors.lastname: Kumar
authors.affiliation: System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India.
authors.forename: A
authors.initials: A
authors.lastname: Pandey
authors.affiliation: System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India.|Academy of Scientific & Innovative Research, CSIR-IITR Campus, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Jahan
authors.affiliation: System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India.|Academy of Scientific & Innovative Research, CSIR-IITR Campus, Lucknow, India.
authors.forename: D
authors.initials: D
authors.lastname: Kumar
authors.affiliation: System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India.|Academy of Scientific & Innovative Research, CSIR-IITR Campus, Lucknow, India.
authors.forename: C S
authors.initials: CS
authors.lastname: Rajpurohit
authors.affiliation: System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India.|Academy of Scientific & Innovative Research, CSIR-IITR Campus, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.affiliation: System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India.|Academy of Scientific & Innovative Research, CSIR-IITR Campus, Lucknow, India.
authors.forename: V K
authors.initials: VK
authors.lastname: Khanna
authors.affiliation: System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India. abpant@iitr.res.in.|Academy of Scientific & Innovative Research, CSIR-IITR Campus, Lucknow, India. abpant@iitr.res.in.
authors.forename: A B
authors.initials: AB
authors.lastname: Pant
mesh_terms: D000818:Animals; D001343:Autophagy / Q000187:drug effects / Q000502:physiology*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000139:chemically induced* / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D020258:Neurotoxicity Syndromes / Q000378:metabolism* / Q000473:pathology
keywords: Autophagy; Developmental neurotoxicity (DNT); Neurodegeneration; Neuroprotection; Neurotoxicity