title: Averting a malaria disaster: will insecticide resistance derail malaria control?
abstract: World Malaria Day 2015 highlighted the progress made in the development of new methods of prevention (vaccines and insecticides) and treatment (single dose drugs) of the disease. However, increasing drug and insecticide resistance threatens the successes made with existing methods. Insecticide resistance has decreased the efficacy of the most commonly used insecticide class of pyrethroids. This decreased efficacy has increased mosquito survival, which is a prelude to rising incidence of malaria and fatalities. Despite intensive research efforts, new insecticides will not reach the market for at least 5 years. Elimination of malaria is not possible without effective mosquito control. Therefore, to combat the threat of resistance, key stakeholders need to rapidly embrace a multifaceted approach including a reduction in the cost of bringing new resistance management methods to market and the streamlining of associated development, policy, and implementation pathways to counter this looming public health catastrophe.
authors.affiliation: Liverpool School of Tropical Medicine, Liverpool, UK. Electronic address: Janet.Hemingway@lstmed.ac.uk.
authors.forename: Janet
authors.initials: J
authors.lastname: Hemingway
authors.affiliation: Liverpool School of Tropical Medicine, Liverpool, UK.
authors.forename: Hilary
authors.initials: H
authors.lastname: Ranson
authors.affiliation: Bill & Melinda Gates Foundation, Seattle, WA, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Magill
authors.affiliation: The Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland.
authors.forename: Jan
authors.initials: J
authors.lastname: Kolaczinski
authors.affiliation: President's Malaria Initiative, US Agency for International Development, Washington, DC, USA.
authors.forename: Christen
authors.initials: C
authors.lastname: Fornadel
authors.affiliation: Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria, Atlanta, GA, USA.
authors.forename: John
authors.initials: J
authors.lastname: Gimnig
authors.affiliation: Wits Research Institute for Malaria, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
authors.forename: Maureen
authors.initials: M
authors.lastname: Coetzee
authors.affiliation: Maladies Infectieuses et Vecteurs: Ecologie, Genetique, Evolution et Contrôle (MIVEGEC), Université de Montpellier, Institut de Recherche pour le Développement, Montpellier, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Simard
authors.affiliation: Centre Muraz, Bobo Dioulasso, Burkina Faso.
authors.forename: Dabiré K
authors.initials: DK
authors.lastname: Roch
authors.affiliation: National Malaria Control Program, N'Djaména, Chad.
authors.forename: Clément Kerah
authors.initials: CK
authors.lastname: Hinzoumbe
authors.affiliation: Rothamsted Research, Harpenden, UK.
authors.forename: John
authors.initials: J
authors.lastname: Pickett
authors.affiliation: University of Oxford, Oxford, UK.
authors.forename: David
authors.initials: D
authors.lastname: Schellenberg
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Gething
authors.affiliation: Insecticide Resistance Action Committee, Crop Life International AISBL, Brussels, Belgium.
authors.forename: Mark
authors.initials: M
authors.lastname: Hoppé
authors.affiliation: Innovative Vector Control Consortium, Liverpool, UK.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Hamon
mesh_terms: D017954:Africa South of the Sahara; D000818:Animals; D000852:Anopheles / Q000502:physiology*; D003140:Communicable Disease Control; D006801:Humans; D007303:Insect Vectors; D007305:Insecticide Resistance; D057148:Insecticide-Treated Bednets; D008288:Malaria / Q000517:prevention & control*; D009032:Mosquito Control; D011722:Pyrethrins
chemical_list: D011722:Pyrethrins