title: [Analysis of the follow-up results concerning pregnancy, delivery and infants after assisted reproductive technique with GnRH-a for luteal support].
abstract: OBJECTIVE
  To investigate the results of follow-up visits of pregnancy course, delivery and infants of women who got clinically pregnant by assisted reproductive technique after gonadotropin-releasing hormone agonist (GnRH-a) added for luteal support, and to analyse the influence of adding GnRH-a in luteal support on the safety of mother and infant.
  
  
  METHODS
  A retrospective analysis was carried out on the medical record from 215 patients who got clinically pregnant after luteal phase long regimen fresh-cycle transfer was operated. According to the differences in luteal support methods, the patients were assigned to Group A (124 patients, progesterone+dydrogesterone group), Group B (91 patients, GnRH-a added group). The patients' pregnancy course, delivery time, and the growth and development of infants within 1-2 years were followed up.
  
  
  RESULTS
  (1) There was no obvious difference between Group A and Group B in terms of the abortion ratio during the early pregnancy (8.1%, 12.1%), the rate of abortion villous deformity (50.0%, 9.1%), the rate of heterotopic pregnancy (10.5%, 5.5%) and rate of twin pregnancy (19.4%, 28.6%; all P>0.05). (2) Compared to group A, during the middle and late pregnancy of single or twin pregnancy in Group B , there was no obvious difference in the rate of fetal chromosomal abnormality, organ malformation incidence, late abortion rate and stillbirth rate (all P>0.05). (3) As to childbirth, in the case of twin pregnancy, there was a higher rate of premature delivery (60.0%, 39.1%; P=0.041), as well as rate of lower birth weight of newborn (56.0%, 34.8%; P=0.037) in group B. (4) The statistics on general growth and development as well as infantile common diseases within 2 years after birth indicated that there was no obvious difference between the two groups in single birth and twin birth subgroup (all P>0.05).
  
  
  CONCLUSIONS
  On the basis of controlling of implanted embryos and reducing the occurrence of twins, GnRH-a luteal support maybe relatively safe and effective.
authors.affiliation: Reproductive Medicine Center, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors.forename: Weiqin
authors.initials: W
authors.lastname: Zhou
authors.forename: Yanping
authors.initials: Y
authors.lastname: Pan
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhuang
authors.forename: Fei
authors.initials: F
authors.lastname: Xia
authors.forename: Caiping
authors.initials: C
authors.lastname: Mao
mesh_terms: D010064:Embryo Implantation; D005260:Female; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D008183:Luteal Phase / Q000502:physiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies
chemical_list: D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone