title: Ion activated in situ gel of gellan gum containing salbutamol sulphate for nasal administration.
abstract: Nasal delivery is the promising approach for rapid onset of action and avoids the first pass metabolism. The main aim of present study was to develop a novel mucoadhesive in situ gel of salbutamol sulphate using gellan gum and hydroxylpropyl methyl cellulose (HPMC) for nasal administration. The formulations were prepared so as to have gelation at physiological ion content after nasal administration. Developed formulations were evaluated for gelation, viscosity, drug content, in vitro mucoadhesion, in vitro drug release study, ex vivo permeation, and histopathology. Formulations showed pH in the range of nasal cavity and optimum viscosity for nasal administration. The mucoadhesive force depends upon concentration of HPMC and drug release was found to be 97.34% in 11h. The histopathology did not detect any damage during ex vivo permeation studies. Hence, in situ gel system of gellan gum may be a promising approach for nasal delivery of salbutamol sulphate for therapeutic improvement.
authors.affiliation: Shri Neminath Jain Brahmacharyashram's Shriman Sureshdada Jain College of Pharmacy, Neminagar, Chandwad, Dist. Nashik 423 101, Maharashtra, India.
authors.forename: Sneha R
authors.initials: SR
authors.lastname: Salunke
authors.affiliation: Shri Neminath Jain Brahmacharyashram's Shriman Sureshdada Jain College of Pharmacy, Neminagar, Chandwad, Dist. Nashik 423 101, Maharashtra, India. Electronic address: sbpatil_99@rediffmail.com.
authors.forename: Sanjay B
authors.initials: SB
authors.lastname: Patil
mesh_terms: D000268:Adhesiveness; D000281:Administration, Intranasal; D000420:Albuterol / Q000008:administration & dosage* / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D065546:Drug Liberation; D004355:Drug Stability; D005782:Gels; D006863:Hydrogen-Ion Concentration; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism; D010539:Permeability; D011135:Polysaccharides, Bacterial / Q000737:chemistry* / Q000633:toxicity; D012449:Safety; D012756:Sheep; D014783:Viscosity
chemical_list: D004337:Drug Carriers; D005782:Gels; D011135:Polysaccharides, Bacterial; C048288:gellan gum; D000420:Albuterol
keywords: Gellan gum; In situ gel; Mucoadhesion