title: Doxorubicin-conjugated CuS nanoparticles for efficient synergistic therapy triggered by near-infrared light.
abstract: To integrate photothermal therapy (PTT) with chemotherapy for improving anticancer efficiency, we developed a novel and multifunctional doxorubicin (DOX) conjugated copper sulfide nanoparticle (CuS-DOX NP) drug delivery system using hydrazone bonds to conjugate carboxyl-functionalized copper sulfide nanoparticles (CuS NPs) and DOX. On the other hand, the hydrazone bonds could be used for improving the DOX release rate (88.0%) by cleavage in a mildly acidic environment irradiated by 808 nm laser light, which could greatly promote chemo-therapeutic efficacy. Simultaneously, CuS NPs which can absorb near infrared (NIR) light produce a clear thermal effect, giving rise to a synergistic therapeutic effect combined with enhanced chemo-therapy. The DOX-conjugated CuS NPs display an evident in vitro cytotoxicity to HeLa cancer cells under 808 nm light irradiation. High tumor inhibition efficacy has been achieved after 14 day in vivo treatment, performed with intravenous administration of CuS-DOX NPs with 808 nm laser irradiation on H22 tumor-bearing mice. The multifunctional system which was achieved by a facile route should be a potential candidate in the anti-cancer field due to the synergistic therapeutic effect, which is superior to any single approach.
authors.affiliation: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China. yangpiaoping@hrbeu.edu.cn daiyunlu58@163.com.
authors.forename: Huiting
authors.initials: H
authors.lastname: Bi
authors.affiliation: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China. yangpiaoping@hrbeu.edu.cn daiyunlu58@163.com.
authors.forename: Yunlu
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China. yangpiaoping@hrbeu.edu.cn daiyunlu58@163.com.
authors.forename: Ruichan
authors.initials: R
authors.lastname: Lv
authors.affiliation: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China. yangpiaoping@hrbeu.edu.cn daiyunlu58@163.com.
authors.forename: Chongna
authors.initials: C
authors.lastname: Zhong
authors.affiliation: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China. yangpiaoping@hrbeu.edu.cn daiyunlu58@163.com.
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.affiliation: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China. yangpiaoping@hrbeu.edu.cn daiyunlu58@163.com.
authors.forename: Shili
authors.initials: S
authors.lastname: Gai
authors.affiliation: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China. yangpiaoping@hrbeu.edu.cn daiyunlu58@163.com.
authors.forename: Arif
authors.initials: A
authors.lastname: Gulzar
authors.affiliation: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China. yangpiaoping@hrbeu.edu.cn daiyunlu58@163.com.
authors.forename: Guixin
authors.initials: G
authors.lastname: Yang
authors.affiliation: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China. yangpiaoping@hrbeu.edu.cn daiyunlu58@163.com.
authors.forename: Piaoping
authors.initials: P
authors.lastname: Yang
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003300:Copper / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D018613:Microscopy, Confocal; D064347:Microscopy, Electrochemical, Scanning; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D017550:Spectroscopy, Fourier Transform Infrared; D014018:Tissue Distribution; D014183:Transplantation, Heterologous; D014961:X-Ray Diffraction
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D003300:Copper; D004317:Doxorubicin; C017846:cupric sulfide