title: Chronic tophaceous gout with unusual large tophi: case report.
abstract: Gout is a metabolic disease, which is characterized by acute or chronic arthritis, and deposition of monosodium urate crystals in joint, bones, soft tissues, and kidneys. But large tophi are unusual in chronic gout. We report the case of a 67-year-oldArabman presenting chronic tophaceous gout with unusual large tophi involving multiple joints: hands, feet, elbows, and knees. Laboratory workup revealed elevated serum uric acid (96 mg/l, normal: 20-74 mg/l), with normal renal function test. In untreated patients, chronic tophaceous gout may develop, which is characterized by chronic destructive polyarticular involvement and tophi. The treatment consists to decrease serum uric acid level which eventually allows the regression of tophi.
authors.affiliation: Rheumatology Department, Medical School, Sidi Mohammed Ibn Abdellah University, Hassan II University Hospital, Fez, Morocco.
authors.forename: Nassira
authors.initials: N
authors.lastname: Aradoini
authors.affiliation: Rheumatology Department, Medical School, Sidi Mohammed Ibn Abdellah University, Hassan II University Hospital, Fez, Morocco.
authors.forename: Sofia
authors.initials: S
authors.lastname: Talbi
authors.affiliation: Rheumatology Department, Medical School, Sidi Mohammed Ibn Abdellah University, Hassan II University Hospital, Fez, Morocco.
authors.forename: Khadija
authors.initials: K
authors.lastname: Berrada
authors.affiliation: Rheumatology Department, Medical School, Sidi Mohammed Ibn Abdellah University, Hassan II University Hospital, Fez, Morocco.
authors.forename: Fatima Zahra
authors.initials: FZ
authors.lastname: Abourazzak
authors.affiliation: Rheumatology Department, Medical School, Sidi Mohammed Ibn Abdellah University, Hassan II University Hospital, Fez, Morocco.
authors.forename: Taoufik
authors.initials: T
authors.lastname: Harzy
mesh_terms: D000368:Aged; D002908:Chronic Disease; D006073:Gout / Q000473:pathology*; D006801:Humans; D007596:Joints / Q000473:pathology*; D008297:Male; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Gout; tophi; urate crystals