title: Pigmented Porokeratosis. A Further Variant?
abstract: Porokeratosis is a clonal disorder of keratinization characterized by the presence of the cornoid lamella. A number of variants of porokeratosis have been described, based on the clinical features and histologic features of the lesions. The authors present a case of porokeratosis with prominent melanocytic hyperplasia, which was biopsied to clinically exclude melanoma. The authors retrospectively studied cases of porokeratosis to look for the presence of melanocytic hyperplasia. Melanocytic hyperplasia was identified in 8 of 31 cases (25.8%). All of the cases except the index case were clinically nonpigmented but arose in solar damaged skin. This case represents a distinct variant of porokeratosis, and the authors propose the designation pigmented porokeratosis. Melanocytic hyperplasia is a benign condition, and it is important that this is not histologically confused with melanoma in situ, particularly in a context of clinically pigmented lesion. Increased recognition of pigmented porokeratosis is essential to avoid an erroneous diagnosis of melanoma in situ.
authors.affiliation: *Pathlab Tauranga, Tauranga, New Zealand; and †DaVinci Clinic, Tauranga, New Zealand.
authors.forename: Tracy S P
authors.initials: TS
authors.lastname: Tan
authors.forename: Ben
authors.initials: B
authors.lastname: Tallon
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008543:Melanins / Q000378:metabolism; D008545:Melanoma / Q000175:diagnosis; D008875:Middle Aged; D017499:Porokeratosis / Q000473:pathology*; D012878:Skin Neoplasms / Q000175:diagnosis
chemical_list: D008543:Melanins