title: Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration.
abstract: To determine whether angiography with swept-source (SS) optical coherence tomography (OCT) identifies subclinical type 1 neovascularization in asymptomatic eyes with intermediate age-related macular degeneration (iAMD).
  
  
  
  Prospective, observational, consecutive case series.
  
  
  
  Patients with asymptomatic iAMD in one eye and neovascular age-related macular degeneration (AMD) in their fellow eye.
  
  
  
  The patients underwent SS OCT angiography (OCTA), fluorescein angiography (FA), and indocyanine green angiography (ICGA), and the images from these 3 angiographic techniques were compared.
  
  
  
  Identification of subclinical type 1 neovascularization with SS OCTA in asymptomatic eyes with iAMD.
  
  
  
  Eleven consecutive patients with iAMD in one eye and neovascular AMD in their fellow eye were imaged with FA, ICGA, and SS OCTA between August 2014 and September 2015. Clinical examination of the 11 eyes revealed drusen and pigmentary abnormalities in the central macula and no evidence of macular fluid on routine OCT imaging. Ten of the 11 eyes had no evidence of leakage on FA and 1 eye had questionable fluorescein leakage. Indocyanine green angiography revealed the presence of central macular plaques in 3 of the 11 asymptomatic eyes with iAMD, and SS OCTA revealed unambiguous type 1 neovascularization corresponding to the plaques in all 3 eyes. Optical coherence tomography angiography did not identify neovascularization in the remaining 8 eyes.
  
  
  
  Swept-source OCTA identified type 1 neovascularization corresponding to ICGA plaques in asymptomatic eyes with iAMD. The ability of OCTA to provide noninvasive, fast, detailed, depth-resolved identification of nonexudative neovascular lesions in eyes with iAMD suggests the need for a new classification system that distinguishes between neovascular and nonneovascular iAMD.
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Luiz
authors.initials: L
authors.lastname: Roisman
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington.
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gregori
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington.
authors.forename: Anqi
authors.initials: A
authors.lastname: Zhang
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington.
authors.forename: Chieh-Li
authors.initials: CL
authors.lastname: Chen
authors.affiliation: Advanced Development, Carl Zeiss Meditec, Inc., Dublin, California.
authors.forename: Mary K
authors.initials: MK
authors.lastname: Durbin
authors.affiliation: Advanced Development, Carl Zeiss Meditec, Inc., Dublin, California.
authors.forename: Lin
authors.initials: L
authors.lastname: An
authors.affiliation: Advanced Development, Carl Zeiss Meditec, Inc., Dublin, California.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Stetson
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Gillian
authors.initials: G
authors.lastname: Robbins
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Andrew
authors.initials: A
authors.lastname: Miller
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Fang
authors.initials: F
authors.lastname: Zheng
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address: prosenfeld@miami.edu.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenfeld
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D058070:Asymptomatic Diseases; D020256:Choroidal Neovascularization / Q000175:diagnosis*; D004396:Coloring Agents / Q000008:administration & dosage; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage; D008297:Male; D011446:Prospective Studies; D012171:Retinal Vessels / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D057135:Wet Macular Degeneration / Q000175:diagnosis*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green