title: Renal Light Chain Deposition Associated with the Formation of Intracellular Crystalline Inclusion Bodies in Podocytes: A Rare Case Report.
abstract: We herein report the case of an elderly woman with bone pain and proteinuria as the main clinical manifestations. The patient was diagnosed with the IgG κ type of multiple myeloma. Her renal pathology consisted of widespread κ light chain protein deposition associated with the formation of large quantities of rod-like crystals in podocytes. This phenomenon is very rare. We explored the significance of this crystal formation via a detailed and descriptive analysis and also performed a literature review, thus providing data to increase the available information about this type of disease.
authors.affiliation: Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, China.
authors.forename: Yuan-da
authors.initials: YD
authors.lastname: Wang
authors.forename: Zhe-yi
authors.initials: ZY
authors.lastname: Dong
authors.forename: Xue-guang
authors.initials: XG
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Yin
authors.forename: Qiang
authors.initials: Q
authors.lastname: Qiu
authors.forename: Xiang-mei
authors.initials: XM
authors.lastname: Chen
mesh_terms: D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D001847:Bone Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D003404:Creatinine / Q000378:metabolism; D003460:Crystallization; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism*; D002479:Inclusion Bodies / Q000378:metabolism*; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D050199:Podocytes / Q000473:pathology; D011507:Proteinuria / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007145:Immunoglobulin kappa-Chains; D003404:Creatinine