title: HSPB1 polymorphisms might be associated with radiation-induced damage risk in lung cancer patients treated with radiotherapy.
abstract: Several studies investigating the association between heat shock protein beta-1 (HSPB1) polymorphisms and radiation-induced damage in lung cancer patients administrated with radiotherapy have derived conflicting results. This meta-analysis aimed to assess the association between the HSPB1 genes' (rs2868370 and rs2868371) polymorphisms and the risk of radiation-induced damage in lung cancer patients. After an electronic literature search, four articles including six studies were found to be eligible for this meta-analysis. No association was observed between rs2868370 genotypes and radiation-induced damage risk. However, rs2868371 showed a statistically increased risk of radiation-induced damage under CC vs. CG/GG model (OR = 1.59, 95 % CI = 1.10-2.29). Subgroup analysis by ethnicity showed that the genotypes of rs2868371 were also associated with a significantly increased risk of radiation-induced damage in CC vs. CG/GG model (OR = 1.86, 95 % CI = 1.21-2.83) among mixed ethnicities which are mainly comprised of white people. When the data was stratified by organ-damaged, a significant association was only observed in the esophagus group (OR = 2.94, 95 % CI = 1.35-6.37, for CC vs. CG/GG model). In conclusion, the present study demonstrated that the rs2868371 genotypes of HSPB1 might be associated with radiation-induced esophagus damage risk, especially in Caucasians but not in the Asian population.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine and Geriatrics, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Li
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine and Geriatrics, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Xu
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine and Geriatrics, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine and Geriatrics, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China. medicalworker001@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Shu
mesh_terms: D044466:Asian People / Q000235:genetics; D016207:Cytokines / Q000378:metabolism; D004947:Esophagus / Q000528:radiation effects; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008168:Lung / Q000528:radiation effects; D008175:Lung Neoplasms / Q000235:genetics* / Q000532:radiotherapy; D009363:Neoplasm Proteins / Q000235:genetics* / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D011832:Radiation Injuries / Q000209:etiology / Q000235:genetics*; D011878:Radiotherapy / Q000009:adverse effects*; D012306:Risk; D044465:White People / Q000235:genetics
chemical_list: D016207:Cytokines; C113285:HSBP1 protein, human; D006360:Heat-Shock Proteins; D009363:Neoplasm Proteins
keywords: Damage; HSPB1; Lung cancer; Polymorphism; Radiotherapy