title: Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress.
abstract: This paper studied the chronic fatigue induced by excessive exercise and the restoration effects of Astragalus polysaccharides (APS) on mitochondria. In vivo, we found that excessive exercise could cause oxidative stress statue which led to morphological and functional changes of mitochondria. The changes, including imbalance between mitochondria fusion-fission processes, activation of mitophagy, and decrease of PGC-1α expression, could be restored by APS. We further confirmed in vitro, and what is more, we found that APS may ameliorate mitochondrial dysfunction through Sirt1 pathway. Based on the results, we may figure out part of the molecular mechanism of mitochondrial amelioration by APS.
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Department of Gastrointestinal Surgery, Shunde First People's Hospital, Southern Medical University, Guangdong 528300, China; Department of Traditional Chinese Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou 510280, China; Department of Nephrology, Southern Medical University TCM-Integrated Hospital, Guangzhou 510515, China.
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Huang
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Gastrointestinal Surgery, Shunde First People's Hospital, Southern Medical University, Guangdong 528300, China.
authors.forename: Da-Jian
authors.initials: DJ
authors.lastname: Zhu
authors.affiliation: Department of Traditional Chinese Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou 510280, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Department of Nephrology, Southern Medical University TCM-Integrated Hospital, Guangzhou 510515, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yin
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
authors.forename: De-Xiu
authors.initials: DX
authors.lastname: Chen
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Department of Traditional Chinese Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou 510280, China; Department of Nephrology, Southern Medical University TCM-Integrated Hospital, Guangzhou 510515, China.
authors.forename: Lian-Bo
authors.initials: LB
authors.lastname: Wei
mesh_terms: D000818:Animals; D027883:Astragalus Plant / Q000737:chemistry*; D001343:Autophagy / Q000187:drug effects / Q000235:genetics; D019587:Dietary Supplements; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D008807:Mice, Inbred BALB C; D008856:Microscopy, Fluorescence; D063154:Mitochondrial Dynamics / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects* / Q000235:genetics; D010805:Physical Conditioning, Animal; D010807:Physical Endurance; D011134:Polysaccharides / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D011134:Polysaccharides; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53