title: Superior Efficacy of an Herbal-based Cosmeceutical Compared With Common Prescription and Cosmetic Antiaging Therapies.
abstract: BACKGROUND
  Research has shown that a disrupted stratum corneum permeability barrier coupled with chronic inflammation induce signs of extrinsic aging (photoaging). An novel herbal-based three product cosmeceutical regimen used to reverse these two anomalies that does not contain retinol, soy, niacinamide, tea, L-ascorbic acid or esters, hydroxy acids, tocopherol, or growth factors was tested in six human clinical trials to determine effectiveness and safety in reversing photoaging.
  
  
  METHODS
  Six randomized split face, double blind, prospective, controlled clinical trials involving a total of 110 subjects compared a cosmeceutical blend of novel herbs in regimens consisting of one to three products to several common antiaging topical treatments. These comparative products include prescription tretinoin, physician strength idebenone, kinetin, polyhydroxy, lactic and glycolic acids in reversing signs of photoaging.
  
  
  RESULTS
  The novel cosmeceutical blend regimen showed superior efficacy and safety in all six trials.
  
  
  CONCLUSIONS
  These trials substantiate that herbs not used in common antiaging products effectively and safely mitigate and reverse photoaging signs and symptoms. The novel concept of treating photoaging and preventing its progression by repairing and optimizing the stratum corneum barrier, while reversing and inhibiting chronic cutaneous inflammation, has now been proven.
authors.forename: Carl R
authors.initials: CR
authors.lastname: Thornfeldt
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Rizer
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000068937:Cosmeceuticals / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D028321:Plant Preparations / Q000008:administration & dosage*; D011446:Prospective Studies; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage; D014801:Vitamin A / Q000008:administration & dosage
chemical_list: D000068937:Cosmeceuticals; D003879:Dermatologic Agents; D028321:Plant Preparations; D014801:Vitamin A; D014212:Tretinoin