title: Multimodality Imaging of Cardiac Transthyretin Amyloidosis 16 Years After a Domino Liver Transplantation.
abstract: We report the case of a 62-year-old man hospitalized in May 2015 for symptomatic heart failure. His medical history included two liver transplantations. The first liver transplantation was performed in 1999 for a mixed alcoholic and hepatitis C-related cirrhosis and the patient received the liver of another patient with Val30Met transthyretin amyloidosis using the domino technique. In 2008, he complained of neuropathic pains and an iatrogenic-acquired transthyretin amyloidosis was diagnosed. On cardiac evaluation, amyloidosis was suspected. In March 2010, a second liver transplantation was performed with a deceased donor without complication. In May 2015, a first episode of symptomatic heart failure occurred and cardiac amyloidosis was investigated by a multimodality evaluation. Electrocardiogram, cardiac biomarkers, echocardiography, and cardiac MRI were in favor of the diagnosis of amyloidosis, whereas99mTc-dicarboxypropane diphosphonate scintigraphy was not. Endomyocardial biopsy finally confirmed the positive diagnosis of iatrogenic-acquired cardiac amyloidosis. This case is, to the best of our knowledge, the first to report biopsy-proven cardiac amyloidosis induced by domino liver transplantation and progressing heart failure in spite of retransplantation. The diagnostic modalities are discussed. This case should alert physicians to the cardiac risk in domino liver transplanted patients.
authors.affiliation: AP-HP, Service de Cardiologie, Hôpital Béclère, Clamart, France.
authors.forename: M Y
authors.initials: MY
authors.lastname: Bechiri
authors.affiliation: AP-HP, Service de Cardiologie, Hôpital Béclère, Clamart, France.
authors.forename: L
authors.initials: L
authors.lastname: Eliahou
authors.affiliation: AP-HP, Service de Médecine Nucléaire, Hôpital Bichat Claude Bernard, Paris, France.|INSERM U1148, Université Denis Diderot Paris 7, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Rouzet
authors.affiliation: AP-HP, Service d'Anatomie Pathologique, Hôpital Pitié Salpêtrière, Paris, France.
authors.forename: P-J
authors.initials: PJ
authors.lastname: Fouret
authors.affiliation: AP-HP, Centre Hépato-biliaire, Hôpital Paul Brousse, Villejuif, France.|INSERM U1193, Villejuif, France.
authors.forename: T
authors.initials: T
authors.lastname: Antonini
authors.affiliation: AP-HP, Centre Hépato-biliaire, Hôpital Paul Brousse, Villejuif, France.|INSERM U1193, Villejuif, France.|Université Paris-Sud, Villejuif Le Kremlin-Bicêtre, France.
authors.forename: D
authors.initials: D
authors.lastname: Samuel
authors.affiliation: AP-HP, Centre Hépato-biliaire, Hôpital Paul Brousse, Villejuif, France.|INSERM U935, Villejuif, France.|Université Paris-Sud, Villejuif Le Kremlin-Bicêtre, France.
authors.forename: R
authors.initials: R
authors.lastname: Adam
authors.affiliation: AP-HP, FILNEMUS, INSERM U1191, Service de Neurologie, Hôpital Bicêtre, le Kremlin Bicêtre, France.|Université Paris-Sud, Villejuif Le Kremlin-Bicêtre, France.
authors.forename: D
authors.initials: D
authors.lastname: Adams
authors.affiliation: AP-HP, Service de Cardiologie, Hôpital Béclère, Clamart, France.|Université Paris-Sud, Villejuif Le Kremlin-Bicêtre, France.
authors.forename: M S
authors.initials: MS
authors.lastname: Slama
authors.affiliation: AP-HP, Service de Cardiologie, Hôpital Béclère, Clamart, France.|Université Paris-Sud, Villejuif Le Kremlin-Bicêtre, France.|INSERM U1180, Université Paris-Saclay, Chatenay Malabry, France.
authors.forename: V
authors.identifier: http://orcid.org/0000-0001-5971-1235
authors.initials: V
authors.lastname: Algalarrondo
keywords: clinical research/practice; domino transplantation; heart disease: metabolic; liver transplantation/hepatology; retransplantation