title: Diagnostic and therapeutic features associated with modification of quality-of-life's outcomes between one and six months after major surgery for head and neck cancer.
abstract: BACKGROUND
  Treatments used in head and neck cancer greatly impact the physical, psychological and functional state of patients. Evaluation of quality of life has become an integral part of the treatment.
  
  
  OBJECTIVE
  This retrospective study evaluates features involved in changes in quality of life after major surgery for head and neck cancer within six months, according to self-reported outcomes.
  
  
  METHODS
  One hundred and thirty patients completed the University of Washington Quality of Life questionnaire one and six months after major surgery for head and neck cancer. A multivariate model was used to evaluate which diagnostic and therapeutic features were related to improvement of quality of life within a six-month period.
  
  
  RESULTS
  Significant improvement in most features related to quality of life was already recognizable at six months. Patients submitted to more invasive treatment had the biggest improvement in quality of life between time-points, as well as those patients with bigger tumors.
  
  
  CONCLUSIONS
  After major surgery, patients may undergo fast recovery, with overall quality of life likely to improve in the short-term. Clinicians must be aware of the importance of dealing with treatment-related issues immediately after surgery, with hopeful possibility of on-the-upgrade results.
authors.affiliation: Dental Science Department, Division of Oral Medicine and Pathology, Trieste, Italy. Electronic address: marghe87gobbo@gmail.com.
authors.forename: Margherita
authors.initials: M
authors.lastname: Gobbo
authors.affiliation: University of Trieste, Hospital of Cattinara, ENT Clinic, Head and Neck Department, Trieste, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Bullo
authors.affiliation: Dental Science Department, Division of Oral Medicine and Pathology, Trieste, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Perinetti
authors.affiliation: University of Trieste, Hospital of Cattinara, ENT Clinic, Head and Neck Department, Trieste, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Gatto
authors.affiliation: Dental Science Department, Division of Oral Medicine and Pathology, Trieste, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Ottaviani
authors.affiliation: Dental Science Department, Division of Oral Medicine and Pathology, Trieste, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Biasotto
authors.affiliation: University of Trieste, Hospital of Cattinara, ENT Clinic, Head and Neck Department, Trieste, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Tirelli
mesh_terms: D000368:Aged; D005260:Female; D006258:Head and Neck Neoplasms / Q000523:psychology* / Q000601:surgery*; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011788:Quality of Life / Q000523:psychology*; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors
keywords: Cirurgia; Câncer de cabeça e pescoço; Head and neck cancer; Qualidade de vida; Quality of life; Surgery