title: Primary signet ring cell carcinoma of the cervix: A case report and review of the literature.
abstract: BACKGROUND
  Primary signet cell carcinoma of the cervix has been reported only in 18 cases to date.
  
  
  METHODS
  A 48-year-old woman was seen at our Gynecologic Oncology Unit, because she complained postcoital bleeding during the last three months. She had 1-2 cm cervical mass, originating from the endocervical canal. A biopsy revealed a signet ring cell-type adenocarcinoma. Suspected primary sites were excluded after gastroscopy, colonoscopy and mammography. The patient underwent a laparoscopic type-3 radical hysterectomy with bilateral salpingo-oophorectomy, pelvic lymph node dissection and paraaortic lymph node dissection with a presumed diagnosis of primary signet ring cell carcinoma of the cervix. Microscopically, the tumour consisted of 70% signet ring cell type and 30% endocervical adenocarcinoma. She did not receive any adjuvant treatment. Follow-up at 18 months after surgery showed no evidence of recurrence.
  
  
  CONCLUSIONS
  Nineteenth case of a primary signet ring cell carcinoma of the cervix was presented. Immunohistochemical studies and HPV DNA positivity may help in diagnosis.
  
  
  CONCLUSIONS
  It is crucial to differentiate primary tumour from metastatic signet cell carcinoma, while treatment and prognosis differ significantly.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
authors.forename: Veysel
authors.initials: V
authors.lastname: Sal
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Medical Faculty, Istanbul University, Turkey. Electronic address: ilkerkahramanoglu@hotmail.com.
authors.forename: Ilker
authors.initials: I
authors.lastname: Kahramanoglu
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Turan
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
authors.forename: Nedim
authors.initials: N
authors.lastname: Tokgozoglu
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
authors.forename: Tugan
authors.initials: T
authors.lastname: Bese
authors.affiliation: Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
authors.forename: Ovgu
authors.initials: O
authors.lastname: Aydin
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
authors.forename: Fuat
authors.initials: F
authors.lastname: Demirkiran
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
authors.forename: Macit
authors.initials: M
authors.lastname: Arvas
keywords: Cervical; Cytokeratin; Immunohistochemical; Primary; Signet cell