title: Differences in expression of gut-homing receptors on CD4+ T cells in black and white HIV-negative men who have sex with men.
abstract: HIV incidence rates are higher among black men who have sex with men (BMSM) as compared with MSM of other race/ethnicities in the USA. We found that blood memory CD4 cells from BMSM express higher levels of α4β7, the gut-homing integrin, compared with white MSM. Higher expression of α4β7 on blood CD4 cells correlated with higher percentage of proliferating CD4α4β7 cells in rectal tissue suggesting increased trafficking of potential HIV target cells to rectal mucosa could increase HIV susceptibility among BMSM.
authors.affiliation: aDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine bDepartment of Epidemiology, Rollins School of Public Health, Emory University cYerkes National Primate Research Center and the Emory Vaccine Center, Emory University dHubert Department of Global Health, Rollins School of Public Health, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Colleen F
authors.initials: CF
authors.lastname: Kelley
authors.forename: Lilin
authors.initials: L
authors.lastname: Lai
authors.forename: Chris
authors.initials: C
authors.lastname: Ibegbu
authors.forename: Eli S
authors.initials: ES
authors.lastname: Rosenberg
authors.forename: Surinder
authors.initials: S
authors.lastname: Kaur
authors.forename: Kalpana
authors.initials: K
authors.lastname: Patel
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Mulligan
authors.forename: Vincent C
authors.initials: VC
authors.lastname: Marconi
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Sullivan
authors.forename: Rama R
authors.initials: RR
authors.lastname: Amara
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry* / Q000276:immunology*; D018451:Homosexuality, Male; D006801:Humans; D016023:Integrins / Q000032:analysis*; D007413:Intestinal Mucosa / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016201:Receptors, Lymphocyte Homing / Q000032:analysis*; D012007:Rectum / Q000276:immunology*; D014481:United States; D044465:White People; D055815:Young Adult
chemical_list: D016023:Integrins; D016201:Receptors, Lymphocyte Homing