title: Biomaterials-based strategies for salivary gland tissue regeneration.
abstract: The salivary gland is a complex, secretory tissue that produces saliva and maintains oral homeostasis. Radiation induced salivary gland atrophy, manifested as "dry mouth" or xerostomia, poses a significant clinical challenge. Tissue engineering recently has emerged as an alternative, long-term treatment strategy for xerostomia. In this review, we summarize recent efforts towards the development of functional and implantable salivary glands utilizing designed polymeric substrates or synthetic matrices/scaffolds. Although the in vitro engineering of a complex implantable salivary gland is technically challenging, opportunities exist for multidisciplinary teams to assemble implantable and secretory tissue modules by combining stem/progenitor cells found in the adult glands with biomimetic and cell-instructive materials.
authors.affiliation: Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.
authors.forename: Tugba
authors.initials: T
authors.lastname: Ozdemir
authors.forename: Eric W
authors.initials: EW
authors.lastname: Fowler
authors.forename: Ying
authors.initials: Y
authors.lastname: Hao
authors.forename: Anitha
authors.initials: A
authors.lastname: Ravikrishnan
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Harrington
authors.forename: Robert L
authors.initials: RL
authors.lastname: Witt
authors.forename: Mary C
authors.initials: MC
authors.lastname: Farach-Carson
authors.forename: Swati
authors.initials: S
authors.lastname: Pradhan-Bhatt
authors.forename: Xinqiao
authors.initials: X
authors.lastname: Jia
mesh_terms: D000328:Adult; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D012466:Salivary Gland Diseases / Q000628:therapy*; D012469:Salivary Glands / Q000737:chemistry / Q000254:growth & development / Q000503:physiopathology*; D013234:Stem Cells / Q000737:chemistry / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*; D014987:Xerostomia / Q000503:physiopathology
chemical_list: D001672:Biocompatible Materials