title: Sclerosing bone dysplasias: genetic, clinical and radiology update of hereditary and non-hereditary disorders.
abstract: There is a wide variety of hereditary and non-hereditary bone dysplasias, many with unique radiographic findings. Hereditary bony dysplasias include osteopoikilosis, osteopathia striata, osteopetrosis, progressive diaphyseal dysplasia, hereditary multiple diaphyseal sclerosis and pyknodysostosis. Non-hereditary dysplasias include melorheostosis, intramedullary osteosclerosis and overlap syndromes. Although many of these dysplasias are uncommon, radiologists should be familiar with their genetic, clinical and imaging findings to allow for differentiation from acquired causes of bony sclerosis. We present an overview of hereditary and non-hereditary bony dysplasias with focus on the pathogenesis, clinical and radiographic findings of each disorder.
authors.affiliation: 1 Department of Radiology, Universitair Ziekenhuis Brussel, Brussel, Belgium.
authors.forename: Cedric
authors.initials: C
authors.lastname: Boulet
authors.affiliation: 2 Department of Radiology, Royal Free Hospital, London, UK.
authors.forename: Hardi
authors.initials: H
authors.lastname: Madani
authors.affiliation: 3 Department of Radiology, Wake Forest University, Winston Salem, NC, USA.
authors.forename: Leon
authors.initials: L
authors.lastname: Lenchik
authors.affiliation: 4 Department of Radiology, Universitair Ziekenhuis Anwerpen, Antwerpen, Belgium.
authors.forename: Filip
authors.initials: F
authors.lastname: Vanhoenacker
authors.affiliation: 5 Department of Medicine, Indira Gandhi Medical College and Research Institute, Pondicherry, India.
authors.forename: Deepak S
authors.initials: DS
authors.lastname: Amalnath
authors.affiliation: 1 Department of Radiology, Universitair Ziekenhuis Brussel, Brussel, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: de Mey
authors.affiliation: 1 Department of Radiology, Universitair Ziekenhuis Brussel, Brussel, Belgium.
authors.forename: Michel
authors.initials: M
authors.lastname: De Maeseneer
mesh_terms: D001848:Bone Diseases, Developmental / Q000000981:diagnostic imaging* / Q000235:genetics*; D003937:Diagnosis, Differential; D019317:Evidence-Based Medicine; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D010026:Osteosclerosis / Q000000981:diagnostic imaging* / Q000235:genetics*