title: Adenocarcinoma arising from chronic perianal crohn's disease: a case report.
abstract: Malignant transformation of perineal fistula in Crohn's disease has rarely been reported. We report a case of Crohn's disease with recurrent perineal fistulas. A 36-year-old male, diagnosed with Crohn's disease at the age of 24, developed adenocarcinoma in an anorectal fistula that had existed for years. He was treated with adjuvant chemoradiotherapy but died. A high index of suspicion and regular surveillance is recommended in chronic anorectal fistulas in Crohn's disease. The shorter duration of Crohn's fistulas prior to malignant degeneration necessitates an aggressive approach to rule out cancer.
authors.affiliation: Department of Gastroenterology II, Mohamed V Teaching Military Hospital, Mohamed V-Souissi University, Rabat, Morocco.
authors.forename: Hanane
authors.initials: H
authors.lastname: Massit
authors.affiliation: Department of Radiology, Mohamed V Teaching Military Hospital, Mohamed V-Souissi University, Rabat, Morocco.
authors.forename: Meryem
authors.initials: M
authors.lastname: Edderai
authors.affiliation: Department of Radiology, Mohamed V Teaching Military Hospital, Mohamed V-Souissi University, Rabat, Morocco.
authors.forename: Rachida
authors.initials: R
authors.lastname: Saouab
authors.affiliation: Department of Gastroenterology II, Mohamed V Teaching Military Hospital, Mohamed V-Souissi University, Rabat, Morocco.
authors.forename: Hassan
authors.initials: H
authors.lastname: Seddik
authors.affiliation: Department of Radiology, Mohamed V Teaching Military Hospital, Mohamed V-Souissi University, Rabat, Morocco.
authors.forename: Jamal
authors.initials: J
authors.lastname: El Fenni
authors.affiliation: Department of Gastroenterology II, Mohamed V Teaching Military Hospital, Mohamed V-Souissi University, Rabat, Morocco.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Benkirane
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D000328:Adult; D059186:Chemoradiotherapy, Adjuvant / Q000379:methods; D003424:Crohn Disease / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D012003:Rectal Fistula / Q000209:etiology* / Q000473:pathology; D012004:Rectal Neoplasms / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D012008:Recurrence; D013997:Time Factors
keywords: Crohn′s disease; perianal disease; perineal adenocarcinoma