title: Serum Metabolomic Profiling of Rats by Intervention of Aconitum soongaricum.
abstract: To understand the toxic mechanism and to find the changes in the endogenous metabolites of Aconitum soongaricum Stapf for clinical detection, a combination of 1H NMR spectroscopy and multivariate statistical analysis was applied to examine the metabolic profiles of the blood serum samples collected from the rat model. In total, thirteen biomarkers of A. soongaricum were found and identified. It turned out that A. soongaricum treatment may partially disorder the metabolism. The study has shown the potential application of NMR-based metabolomic analysis in providing further insights into the toxicity caused by A. soongaricum.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Jiao
authors.initials: J
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Lei
authors.forename: Wenjing
authors.initials: W
authors.lastname: He
authors.forename: Yun
authors.initials: Y
authors.lastname: Sun
mesh_terms: D031841:Aconitum; D000818:Animals; D005786:Gene Expression Regulation; D055442:Metabolome / Q000502:physiology*; D018517:Plant Roots; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013047:Specific Pathogen-Free Organisms