title: A Comparative Study of Intravenous Immunoglobulin and Subcutaneous Immunoglobulin in Adult Patients with Primary Immunodeficiency Diseases: A Systematic Review and Meta-Analysis.
abstract: Subcutaneous immunoglobulin (SCIG) is a new therapeutic procedure for patients with primary immunodeficiency (PI). This research is a systematic review of studies on the efficacy and safety of intravenous immunoglobulin (IVIG) and SCIG in adult patients with PI. This study includes a systematic review of cohorts and randomized clinical trials (24 articles) from 5 databases with no time limits. Random effects meta-analysis was performed for outcomes such as efficacy and safety. Standard mean difference (SMD) of serum immunoglobulin level was equal to 0.336 (P <0.01; 0.205-0.467) and the odds ratio (OR) of side effects was 0.497 (P=0.1; 0.180-1.371). The results indicate that SCIG leads to a higher level of immunoglobulin and a reduction in side effects but shows the same infection rate as IVIG. Our analysis shows that shifting from IVIG to SCIG therapy can have clinical benefits for PI patients.
authors.affiliation: a Department of Health Management, School of Health Management & Information Sciences , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Hosein
authors.initials: H
authors.lastname: Shabaninejad
authors.affiliation: b School of Health Management & Information Sciences , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Asra
authors.initials: A
authors.lastname: Asgharzadeh
authors.affiliation: c Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
authors.affiliation: d Health management and economics research center , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Aziz
authors.initials: A
authors.lastname: Rezapoor
mesh_terms: D000328:Adult; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage* / Q000592:standards; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*; D055104:Infusions, Subcutaneous / Q000592:standards
chemical_list: D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous
keywords: Intravenous immunoglobulin; Subcutaneous immunoglobulin; efficacy; primary immunodeficiency; safety