title: [Experimental study of metabonomics in the diagnosis of allergic rhinitis in mice].
abstract: OBJECTIVE
  To investigate the application of metabonomics in the diagnosis of allergic rhinitis.
  
  
  METHODS
  Eighty male Kunming mice were randomly divided into two groups, control group (30 mice) and allergic rhinitis (AR) group (50 mice). After modeling, removal behavior score more than 6 and retain 30 mice behavior score equal to 6.Collect the mice peripheral blood and preparate blood serum, using UPLC-MS chromatographic separation and detection. The data were pretreated by SPSS and Excel, after chromatographic peak matching by MZmine. Firstly , delete interference data in accordance with the 80% rule .Then, the investigate data were analyzed by PLS-DA and PCA-X.
  
  
  RESULTS
  Three-dimensional view of the control group (30 mice) and AR group (30 mice) blood serum data was drawn using PCA-X and PLS-DA method. The two groups of samples could be completely separated through views, which showed that there was a significant difference between the two groups of data. There were some differences in the blood metabolites between the control group and AR group .
  
  
  CONCLUSIONS
  The study showed that it was scientific and feasible to diagnose AR using the metabonomics.
authors.affiliation: Department of Otorhinolaryngology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: A
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Q F
authors.initials: QF
authors.lastname: Li
authors.affiliation: Department of Otorhinolaryngology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: G Q
authors.initials: GQ
authors.lastname: Zhang
authors.affiliation: Physcial Testing and Chemical Analysis Laboratory, Police Security Bureau of Shanxi Province, Taiyuan 030001, China.
authors.forename: C Q
authors.initials: CQ
authors.lastname: Zhao
mesh_terms: D000818:Animals; D008297:Male; D055432:Metabolomics; D051379:Mice; D065631:Rhinitis, Allergic / Q000175:diagnosis* / Q000378:metabolism*