title: Intrahepatic biliary papillomatosis associated with malignant transformation: report of two cases and review of the literature.
abstract: Biliary papillomatosis (BP) is a rare disease characterized by multiple numerous papillary adenomas in both the intrahepatic and extrahepatic biliary tree. Due to its high recurrence rate and frequent transformation to malignancy, BP should not be considered a benign disease, and a radical resection with an adequate resection margin is advocated in cases of localized intrahepatic biliary papillomatosis. Since BP is a rare disease and its clinical features and outcomes are not well known, it's really difficult to diagnose the disease before operation. We encountered two cases diagnosed as intrahepatic biliary papillomatosis postoperatively, and herein present the diagnostic difficulties and therapeutic options for this rare disease.
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University Jinan 250012, Shandong, China.
authors.forename: Zequn
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University Jinan 250012, Shandong, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Gao
authors.affiliation: Department of Pathology, Qilu Hospital of Shandong University Jinan 250012, Shandong, China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University Jinan 250012, Shandong, China.
authors.forename: Zhaobin
authors.initials: Z
authors.lastname: He
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University Jinan 250012, Shandong, China.
authors.forename: Kaiser
authors.initials: K
authors.lastname: Abm
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University Jinan 250012, Shandong, China.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Biswas
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University Jinan 250012, Shandong, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Niu
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University Jinan 250012, Shandong, China.
authors.forename: Weibo
authors.initials: W
authors.lastname: Niu
keywords: Biliary papillomatosis; cholangiocarcinoma; malignant transformation