title: Understanding the nanoparticle-protein corona complexes using computational and experimental methods.
abstract: Nanoparticles (NP) have capability to adsorb proteins from biological fluids and form protein layer, which is called protein corona. As the cell sees corona coated NPs, the protein corona can dictate biological response to NPs. The composition of protein corona is varied by physicochemical properties of NPs including size, shape, surface chemistry. Processing of protein adsorption is dynamic phenomena; to that end, a protein may desorb or leave a surface vacancy that is rapidly filled by another protein and cause changes in the corona composition mainly by the Vroman effect. In this review, we discuss the interaction between NP and proteins and the available techniques for identification of NP-bound proteins. Also we review current developed computational methods for understanding the NP-protein complex interactions.
authors.affiliation: Department of Chemistry, Tarbiat Modares University, Tehran, Iran.
authors.forename: B
authors.initials: B
authors.lastname: Kharazian
authors.affiliation: Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran. Electronic address: hadipour@modares.ac.ir.
authors.forename: N L
authors.initials: NL
authors.lastname: Hadipour
authors.affiliation: Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran; Center of Excellence in Complex Systems and Condensed Matter (CSCM), Sharif University of Technology, Tehran 1458889694, Iran.
authors.forename: M R
authors.initials: MR
authors.lastname: Ejtehadi
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods*; D006801:Humans; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*; D011487:Protein Conformation; D000066970:Protein Corona / Q000737:chemistry*
chemical_list: D000066970:Protein Corona
keywords: Interaction; Nanoparticle; Protein corona; Simulation