title: [The assessment of symptomatic burden among Ph/BCR- ABL negative myeloproliferative neoplasm patients].
abstract: OBJECTIVE
  To investigate the value of myeloproliferative neoplasms Symptom Assessment Form total symptom score (MPN-SAF-TSS)in assessing constitutional symptoms among Ph/BCR- ABL negative myeloproliferative neoplasm (MPN)patients.
  
  
  METHODS
  A cohort of 628 MPN patients were evaluated by MPN- SAF- TSS.
  
  
  RESULTS
  Fatigue was the most common symptom (76.0%, 76.2%vs 89.9%)and the highest average severity of all the symptoms (3.46±2.97, 3.47±2.99vs 4.74±3.04 scores)among polycythemia vera (PV), essential thrombocythemia (ET)and primary myelofibrosis (PMF)patients. Using the MPN- SAF- TSS analysis, PMF patients showed highest burden of symptoms (28.9 ± 19.1), followed by PV patients (19.2 ± 16.8), and finally ET patients (17.1 ± 15.3). Instinct differences were observed between PMF and PV patients (χ(2)=6.371,P=0.021), PMF and ET patients (χ(2)= 14.020,P<0.001). No significant difference was found between PV and ET patients (χ(2)=2.281,P=0.191).
  
  
  CONCLUSIONS
  MPN- SAF- TSS was effective in evaluating the symptomatic burden among Ph/BCRABL negative MPN patients and could be used for serial assessment in this clinical setting.
authors.affiliation: Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC. The State Key Laboratory of Experimental Hematology, Tianjin 300020, China.
authors.forename: Junqing
authors.initials: J
authors.lastname: Xu
authors.forename: Zefeng
authors.initials: Z
authors.lastname: Xu
authors.forename: Jingya
authors.initials: J
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Sun
authors.forename: Tiejun
authors.initials: T
authors.lastname: Qin
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hongli
authors.initials: H
authors.lastname: Zhang
authors.forename: Liwei
authors.initials: L
authors.lastname: Fang
authors.forename: Lijuan
authors.initials: L
authors.lastname: Pan
authors.forename: Naibo
authors.initials: N
authors.lastname: Hu
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Qu
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Xiao
mesh_terms: D006801:Humans; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000175:diagnosis* / Q000503:physiopathology; D011087:Polycythemia Vera / Q000150:complications*; D055728:Primary Myelofibrosis / Q000150:complications*; D013920:Thrombocythemia, Essential / Q000150:complications*