title: Endometrial stem cells: clinical application and pathological roles.
abstract: Adult stem cells occur in human endometrium. Menstrual-blood derived stem cells (MenSCs) are mesenchymal stem cells that can be obtained in a non-invasive manner. Due to their rapid proliferation rate, low immunogenicity, and low tumorigenicity, MenSCs are used extensively in tissue engineering. They can be induced into multiple cell lineages under certain conditions. MenSCs contribute to tissue repair via several different mechanisms, highlighting their great promise in clinical applications. Endometrial stem cells may also be used to shed light on the pathogenesis of endometriosis and endometrial carcinoma. This review will cover recent progress in this field.
authors.affiliation: Department of Obstetrics and Gynecology, Reproductive Medical Center, Shengjing Hospital Affiliated to China Medical University Shenyang 110004, Liaoning, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Obstetrics and Gynecology, Reproductive Medical Center, Shengjing Hospital Affiliated to China Medical University Shenyang 110004, Liaoning, China.
authors.forename: Huiting
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Obstetrics and Gynecology, Reproductive Medical Center, Shengjing Hospital Affiliated to China Medical University Shenyang 110004, Liaoning, China.
authors.forename: Dongni
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of Obstetrics and Gynecology, Reproductive Medical Center, Shengjing Hospital Affiliated to China Medical University Shenyang 110004, Liaoning, China.
authors.forename: Jichun
authors.initials: J
authors.lastname: Tan
keywords: Endometrial stem cells; cancer stem cells; endometrial carcinoma; endometriosis; menstrual blood-derived stem cells; molecular mechanisms