title: A New Triterpenoid from the Aerial Parts of Agrimonia pilosa.
abstract: (1S,3R,17R,18R,19R,20R,22R)-1,3,19,22-tetrahydroxy-28-norurs-12-en-2-one (1), along with 5 known triterpenoids (2-6), were isolated from the aerial parts of Agrimonia pilosa Ledeb. Their structures were established based on extensive spectroscopic and MS analysis. The absolute configuration of compound 1 was deduced by circular dichroism (CD). Compound 1 was the first example of a 28-norursene backbone isolated from the genus Agrimonia. Compounds 2-6 were tested for anti-inflammatory activities against RAW 264.7 macrophages. A plausible biosynthetic pathway for compound 1 in A. pilosa was also proposed.
authors.forename: Jiang-Hao
authors.initials: JH
authors.lastname: Ma
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Jiang
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiu-Fang
authors.initials: XF
authors.lastname: Nie
authors.forename: Tie
authors.initials: T
authors.lastname: Yao
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Ding
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Chen
authors.forename: Qiu
authors.initials: Q
authors.lastname: Feng
mesh_terms: D031981:Agrimonia / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D014315:Triterpenes