title: The contribution of SIPA1 and RRP1B germline polymorphisms to breast cancer phenotype, lymph node status and survival in a group of Lithuanian young breast cancer patients.
abstract: The germline polymorphisms in signal-inducing proliferation-associated protein 1 (SIPA1) and ribosomal RNR processing 1B (RRP1B) might be involved in breast cancer metastasis. The aim of this study was to analyze how SIPA1 and RRP1B polymorphisms contribute to breast cancer phenotype, lymph node status and survival. A group of 100 young, I-II stage breast cancer patients were analyzed for SIPA1 and RRP1B polymorphisms with PCR-RFLP assay. SIPA1 c.2760G > A, c.545C > T and RRP1B c.436T > C polymorphisms were associated with lymph node status, survival and tumor grade, respectively. Our results suggest that SIPA1 and RRP1B germline polymorphisms are important for breast cancer prognosis.
authors.affiliation: a Oncology Research Laboratory, Oncology Institute, Lithuanian University of Health Sciences , Kaunas , Lithuania .
authors.forename: Rasa
authors.initials: R
authors.lastname: Ugenskienė
authors.affiliation: b Oncology Institute, Lithuanian University of Health Sciences , Kaunas , Lithuania , and.
authors.forename: Dana
authors.initials: D
authors.lastname: Myrzaliyeva
authors.affiliation: a Oncology Research Laboratory, Oncology Institute, Lithuanian University of Health Sciences , Kaunas , Lithuania .
authors.forename: Roberta
authors.initials: R
authors.lastname: Jankauskaitė
authors.affiliation: b Oncology Institute, Lithuanian University of Health Sciences , Kaunas , Lithuania , and.
authors.forename: Jurgita
authors.initials: J
authors.lastname: Gedminaitė
authors.affiliation: b Oncology Institute, Lithuanian University of Health Sciences , Kaunas , Lithuania , and.
authors.forename: Rasa
authors.initials: R
authors.lastname: Jančiauskienė
authors.affiliation: c Center of Informatics Technologies, Lithuanian University of Health Sciences , Kaunas , Lithuania.
authors.forename: Eglė
authors.initials: E
authors.lastname: Šepetauskienė
authors.affiliation: b Oncology Institute, Lithuanian University of Health Sciences , Kaunas , Lithuania , and.
authors.forename: Elona
authors.initials: E
authors.lastname: Juozaitytė
mesh_terms: D000328:Adult; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D005260:Female; D020690:GTPase-Activating Proteins / Q000235:genetics*; D018095:Germ-Line Mutation; D006801:Humans; D008097:Lithuania; D008207:Lymphatic Metastasis / Q000235:genetics*; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D016019:Survival Analysis
chemical_list: D051017:Apoptosis Regulatory Proteins; D002868:Chromosomal Proteins, Non-Histone; D020690:GTPase-Activating Proteins; D009687:Nuclear Proteins; C574722:RRP1B protein, human; C490403:SIPA1 protein, human
keywords: Breast cancer; genes; genetic polymorphisms; metastasis