title: Aldosterone and type 2 diabetes mellitus.
abstract: Primary hyperaldosteronism (PA) has recently been demonstrated to be strictly associated to metabolic syndrome as compared with essential hypertension (EH). Besides, the characteristics of metabolic syndrome are different in PA compared to EH, as high fasting glucose is more frequent in the former condition. The adverse effect of excess aldosterone on insulin metabolic signaling has generated increasing interest in the role of hyperaldosteronism in the pathogenesis of insulin resistance and resistant hypertension. Moreover, aldosterone receptor antagonist therapy in diabetic and cardiopathic patients improved coronary flow. The aim of this review is to present recent knowledge about the relationship between aldosterone, insulin resistance and diabetes.
authors.forename: Guido
authors.initials: G
authors.lastname: Zavatta
authors.forename: Elena
authors.initials: E
authors.lastname: Casadio
authors.forename: Eleonora
authors.initials: E
authors.lastname: Rinaldi
authors.forename: Uberto
authors.initials: U
authors.lastname: Pagotto
authors.forename: Renato
authors.initials: R
authors.lastname: Pasquali
authors.forename: Valentina
authors.initials: V
authors.lastname: Vicennati
mesh_terms: D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D012084:Renin-Angiotensin System
chemical_list: D001786:Blood Glucose; D007328:Insulin; D000450:Aldosterone; D011188:Potassium