title: Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy.
abstract: The founding member of the Mas-related G-protein-coupled receptor (Mrgpr) family was discovered in 1986. Since then, many more members of this receptor family have been identified in multiple species, and their physiologic functions have been investigated widely. Because they are expressed exclusively in small-diameter primary sensory neurons, the roles of Mrgpr proteins in pain and itch have been best studied. This review will focus specifically on the current knowledge of their roles in pathological pain and the potential development of new pharmacotherapies targeted at some Mrgprs for the treatment of chronic pain. We will also discuss the limitations and future scope of this receptor family in pain treatment.
authors.affiliation: Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
authors.forename: Vineeta
authors.initials: V
authors.lastname: Tiwari
authors.affiliation: Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
authors.forename: Vinod
authors.initials: V
authors.lastname: Tiwari
authors.affiliation: Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
authors.forename: Shaoqiu
authors.initials: S
authors.lastname: He
authors.affiliation: Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
authors.forename: Srinivasa N
authors.initials: SN
authors.lastname: Raja
authors.affiliation: Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
authors.forename: Xinzhong
authors.initials: X
authors.lastname: Dong
authors.affiliation: Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA. yguan1@jhmi.edu.
authors.forename: Yun
authors.initials: Y
authors.lastname: Guan
mesh_terms: D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D005727:Ganglia, Spinal / Q000502:physiology; D006801:Humans; D005810:Multigene Family; D059225:Nociception / Q000187:drug effects / Q000502:physiology*; D009928:Organ Specificity; D010146:Pain / Q000503:physiopathology* / Q000523:psychology; D059408:Pain Management / Q000379:methods*; D011323:Primates; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D012377:Rodentia; D011984:Sensory Receptor Cells / Q000502:physiology; D013045:Species Specificity
chemical_list: D000700:Analgesics; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D043562:Receptors, G-Protein-Coupled
keywords: Dorsal root ganglion; Mas-related G-protein-coupled receptors; Mrgpr; Nerve injury; Pain