title: Polycyclic Spiro Lignans and Biphenyl Tetrahydrofuranone Lignans from Gymnotheca involucrata.
abstract: Four rare polycyclic spiro lignans (1-4) and four new biphenyl tetrahydrofuranone lignans (5-8) were isolated from the whole plant of Gymnotheca involucrata. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis and the absolute configuration of 1 was confirmed by single crystal X-ray diffraction. Bioassay results showed that compounds 2 and 6 exhibited weak antifungal activity against Uromyces viciae-fabae at 100 ppm in leaf-disc assays, while compound 3 demonstrated moderate insecticidal activity against Diabrotica balteata at 500 ppm in an artificial diet assay.
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China.
authors.forename: Shi-Ji
authors.initials: SJ
authors.lastname: Xiao
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China.
authors.forename: Da-Le
authors.initials: DL
authors.lastname: Guo
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xia
authors.affiliation: Syngenta Jealott's Hill International Research Centre, Berkshire, United Kingdom.
authors.forename: Sarah
authors.initials: S
authors.lastname: Allen
authors.affiliation: Syngenta Jealott's Hill International Research Centre, Berkshire, United Kingdom.
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Gu
authors.affiliation: College of Life Sciences, Sichuan University, Chengdu, P. R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China.
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Ding
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001517:Coleoptera / Q000187:drug effects; D018360:Crystallography, X-Ray; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D011083:Polycyclic Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D032134:Saururaceae / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D005663:Furans; D007306:Insecticides; D017705:Lignans; D011083:Polycyclic Compounds