title: Legal and ethical issues of uterus transplantation.
abstract: The clinically detailed report of a successful uterus transplantation and live birth in Sweden, in which a family friend donated her uterus, provides a basis for expanded practice. Family members and friends can serve as living donors without offending legal or ethical prohibitions of paid organ donation, even though family members and friends often engage in reciprocal gift exchanges. Donations from living unrelated sources are more problematic, and there is a need to monitor donors' genuine altruism and motivation. Donation by deceased women-i.e. cadaveric donation-raises issues of uterus suitability for transplantation, and how death is diagnosed. Organs' suitability for donation is often achieved by ventilation to maintain cardiac function for blood circulation, but laws and cultures could deem that a heartbeat indicates donors' live status. Issues could arise concerning ownership and control of organs between recovery from donors and implantation into recipients, and on removal following childbirth, that require legal resolution.
authors.affiliation: Faculty of Law, Faculty of Medicine and Joint Centre for Bioethics, University of Toronto, Toronto, ON, Canada. Electronic address: bernard.dickens@utoronto.ca.
authors.forename: Bernard M
authors.initials: BM
authors.lastname: Dickens
mesh_terms: D058489:46, XX Disorders of Sex Development / Q000601:surgery*; D000013:Congenital Abnormalities / Q000601:surgery*; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006084:Graft Rejection / Q000517:prevention & control*; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D050498:Live Birth; D019520:Living Donors; D008297:Male; D009095:Mullerian Ducts / Q000002:abnormalities*; D011247:Pregnancy; D014599:Uterus / Q000637:transplantation*
chemical_list: D007166:Immunosuppressive Agents
keywords: Altruistic uterus donation; Brain death; Cadaveric uterus donation; Ethics in uterus donation; Legality of uterus donation; Organ transplantation; Uterus donation