title: Cytology of low-grade cribriform cystadenocarcinoma in salivary glands: Cytological and immunohistochemical distinctions from other salivary gland neoplasms.
abstract: Low-grade cribriform cystadenocarcinoma of the parotid gland is rare malignancy that is classified as a variant of cystadenocarcinoma. In routine cytologic slides from fine-needle aspiration of a parotid gland, we found several pseudopapillary clusters comprising mucus-producing cells. They included a few tumor cells having three-dimensional nuclear atypia and slight hyperchromatism, although most of the tumor cells showed bland nuclei. Our initial cytological diagnosis was: "Indeterminate. Uncertain whether cystadenocarcinoma or cystadenoma." The subsequent histological diagnosis was low-grade cribriform cystadenocarcinoma. Immunohistochemical staining showed diffuse and strong reactivity for S-100; tumor nests that were rimmed by p63(+) cells, which suggests intraductal proliferation. Here, we report cytomorphological findings of this case, and discuss cytological and immunohistochemical distinctions between low-grade cribriform cystadenocarcinoma and other salivary gland tumors, including a review of the literature.
authors.affiliation: Department of Clinico-Diagnostic Pathology, Showa University Fujigaoka Hospital, Kanagawa, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Ohta
authors.affiliation: Department of Clinico-Diagnostic Pathology, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hirota
authors.affiliation: Division of Pathology, Department of Oral Diagnostic Sciences, Showa University School of Dentistry, Tokyo, Japan.
authors.forename: Yohko
authors.initials: Y
authors.lastname: Kohno
authors.affiliation: Department of Clinico-Diagnostic Pathology, Showa University Fujigaoka Hospital, Kanagawa, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Kishimoto
authors.affiliation: Department of Clinico-Diagnostic Pathology, Showa University Fujigaoka Hospital, Kanagawa, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Norose
authors.affiliation: Department of Clinico-Diagnostic Pathology, Showa University Fujigaoka Hospital, Kanagawa, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohike
authors.affiliation: Department of Pathology, Clinico-Diagnostic Pathology, Showa University School of Medicine, Tokyo, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Takimoto
authors.affiliation: Department of Pathology, Clinico-Diagnostic Pathology, Showa University School of Medicine, Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Shiokawa
authors.affiliation: Department of Pathology, Clinico-Diagnostic Pathology, Showa University School of Medicine, Tokyo, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Ota
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D002467:Cell Nucleus / Q000473:pathology; D003537:Cystadenoma / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D012468:Salivary Gland Neoplasms / Q000473:pathology*
keywords: cystadenocarcinoma; cytology; fine-needle aspiration (FNA); low-grade cribriform cystadenocarcinoma (LGCCC); parotid gland