title: [Correlations between constipation and the axial symptoms, related motor symptoms in Parkinson's disease].
abstract: OBJECTIVE
  To investigate the clinical characteristics of Parkinson's Disease (PD) patients with constipation and explore the correlation between constipation and motor symptoms.
  
  
  METHODS
  The demographic data of outpatients with PD in our hospital was collected. According to Rome Ⅲ criteria, we evaluated the status of constipation in PD patients. Unified Parkinson's disease rating scale part Ⅲ (UPDRSⅢ), mini-mental state examination (MMSE) were performed in all the included patients.
  
  
  RESULTS
  Among the 158 recruited PD patients, 96 (60.8%) patients had constipation. Among these patients, 41(42.7%) patients experienced constipation before motor symptoms. Compared to those without constipation, PD patients with constipation had higher axial scores (6.8±3.4 vs 4.3±2.5, t=-4.887, P=0.000) and gait/postural stability scores (3.9±2.4 vs 2.4±1.5, t=-4.529, P=0.000), higher proportion of axial and gait/postural stability scores in UPDRSⅢ (32%±11% vs 25%±12%, t=-3.485, P=0.001; 18%±9% vs 15%±10%, t=-2.278, P=0.024), more rapid progression of axial and gait/postural stability symptoms (P<0.05). However, there were no differences in other sub-scores and progression of motor symptoms between the two groups (P>0.05). The PD patients with constipation preceding motor symptoms had higher proportion of axial and gait/postural stability scores in UPDRSⅢ (35%±11% vs 30%±10%, t=2.167, P=0.033; 21%±9% vs 16%±8%, t=2.733, P=0.008), indicating these patients may progress more rapidly, meanwhile, they had later onset age, shorter disease duration (P<0.05). Unconditioned Logistic regression showed that axial score was major influencing factor of constipation in PD patients (P=0.000, OR=1.330).
  
  
  CONCLUSIONS
  PD patients with constipation have severer axial symptoms, indicating the progression of these patients is relatively rapid, especially those with constipation preceding motor symptoms. It is suggested that axial symptoms and constipation are acted as interactional factors in PD.
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Dai
authors.forename: Chengjie
authors.initials: C
authors.lastname: Mao
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Ding
authors.forename: Lijing
authors.initials: L
authors.lastname: Ma
authors.forename: Yunting
authors.initials: Y
authors.lastname: Fu
authors.forename: Huijun
authors.initials: H
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Liu
mesh_terms: D017668:Age of Onset; D003248:Constipation; D018450:Disease Progression; D006801:Humans; D009483:Neuropsychological Tests; D010300:Parkinson Disease