title: Butyrate production from high-fiber diet protects against lymphoma tumor.
abstract: Gut microbiota and dietary fiber are critical for protecting body from obesity, diabetes and cancer. Butyrate, produced in the gut by bacterial fermentation of dietary fibers, is demonstrated to be protective against the development of colorectal cancer as a histone deacetylase (HDAC) inhibitor. We report that high-fiber diet and butyrate significantly inhibited the growth lymphoma tumors. Butyrate induced apoptosis of lymphoma tumor cells and significantly up-regulated histone 3 acetylation (H3ac) level and target genes such as Fas, P21, P27. Our results unravel an instrumental role of fiber diet and their metabolites on lymphoma tumor and demonstrate an intervention potential on the prevention and therapy of lymphoma.
authors.affiliation: a Department of Hematology , The First Affiliated Hospital of Liaoning Medical University , Jinzhou , Liaoning Province , PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: a Department of Hematology , The First Affiliated Hospital of Liaoning Medical University , Jinzhou , Liaoning Province , PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: a Department of Hematology , The First Affiliated Hospital of Liaoning Medical University , Jinzhou , Liaoning Province , PR China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Yu
authors.affiliation: a Department of Hematology , The First Affiliated Hospital of Liaoning Medical University , Jinzhou , Liaoning Province , PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: a Department of Hematology , The First Affiliated Hospital of Liaoning Medical University , Jinzhou , Liaoning Province , PR China.
authors.forename: Limei
authors.initials: L
authors.lastname: Ai
mesh_terms: D000107:Acetylation; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002087:Butyrates / Q000378:metabolism* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004032:Diet; D004043:Dietary Fiber; D004195:Disease Models, Animal; D015870:Gene Expression; D006657:Histones / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000178:diet therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D051379:Mice; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D002087:Butyrates; D004043:Dietary Fiber; D006657:Histones
keywords: Apoptosis; butyrate; fiber diet; lymphoma; microbiota