title: The chemokine CXCL9 expression is associated with better prognosis for colorectal carcinoma patients.
abstract: The chemokine CXCL9 has been demonstrated to play an important role in the development of human malignancies. However, its prognostic significance in cancer patients remains unclear and less is known about its role in colonrectal carcinoma (CRC) patients. In this study, we found that the relative mRNA expression level of CXCL9 in primary colorectal tumor tissues was significantly higher than that in corresponding normal colon tissues. CXCL9 protein expression was also detected in 102 of 130 primary CRC patients by immunochemistry. Thus, CXCL9 might play a vital role in the progression of colorectal cancer. By analyzing the correlation between clinicopathological factors of patients and expression of CXCL9 protein, we showed that the expression of CXCL9 was significantly associated with tumor differentiation, tumor invasion, lymph node metastasis, distant metastasis, and vascular invasion, but not with other factors of CRC patients including age, gender, tumor location and tumor size. Furthermore, by performing Kaplan-Meier method as well as Cox's univariate and multivariate hazard regression model, we found that the higher the CXCL9 expression, the higher overall survival rate was observed, and CXCL9 expression was a significant independent prognostic factor for CRC patients. Therefore, CXCL9 is a useful predictor of better clinical outcome in CRC patients.
authors.affiliation: Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, 200233 Shanghai, China.
authors.forename: Zhenqian
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, 200233 Shanghai, China.
authors.forename: Xiuyan
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, 200233 Shanghai, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, 200233 Shanghai, China.
authors.forename: Zhongnan
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, 200233 Shanghai, China.
authors.forename: Qinchao
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, 200233 Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, 200233 Shanghai, China.
authors.forename: Song
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, 200233 Shanghai, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, 200233 Shanghai, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, 200233 Shanghai, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, 200233 Shanghai, China. Electronic address: wangyu11122@sina.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
mesh_terms: D015153:Blotting, Western; D054370:Chemokine CXCL9 / Q000235:genetics* / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D054370:Chemokine CXCL9; D012333:RNA, Messenger
keywords: CXCL9; Chemokine; Colorectal carcinoma; Prognosis