title: Delayed graft function and chronic allograft nephropathy: diagnostic and prognostic role of neutrophil gelatinase-associated lipocalin.
abstract: BACKGROUND
  Available markers are not reliable parameters to early detect kidney injury in transplanted patients.
  
  
  OBJECTIVE
  Examine neutrophil gelatinase associated lipocalin (NGAL) in early detection of delayed graft function (DGF) and as a long-term predictor of graft outcome.
  
  
  METHODS
  NGAL was evaluated in 124 transplanted patients.
  
  
  RESULTS
  Urinary NGAL levels were associated to a 10% (HR: 1.10; 95% CI: 1.04-1.25; p < 0.001) and 15% (HR: 1.15; 95% CI: 1.09-1.26; p < 0.001) increased risk of DGF and allograft nephropathy progression, respectively.
  
  
  CONCLUSIONS
  NGAL reflects the entity of renal impairment in transplanted patients, representing a biomarker and an independent risk factor for DGF and chronic allograft nephropathy progression.
authors.affiliation: a Department of Internal Medicine , University Hospital of Messina , Messina , Italy .
authors.forename: Antonio
authors.initials: A
authors.lastname: Lacquaniti
authors.affiliation: b Department of Internal Medicine , Mediterranean Institute for Transplantation and Advanced Specialized Therapies, ISMETT, University of Pittsburgh Medical Center , Palermo , Italy .
authors.forename: Chiara
authors.initials: C
authors.lastname: Caccamo
authors.affiliation: b Department of Internal Medicine , Mediterranean Institute for Transplantation and Advanced Specialized Therapies, ISMETT, University of Pittsburgh Medical Center , Palermo , Italy .
authors.forename: Paola
authors.initials: P
authors.lastname: Salis
authors.affiliation: c Department of Pediatric Science , University Hospital of Messina , Messina , Italy .
authors.forename: Valeria
authors.initials: V
authors.lastname: Chirico
authors.affiliation: d Surgery and Abdominal Transplantation Division, Cliniques Universitaires Saint-Luc, Université Catholique De Louvain , Brussels , Belgium , and.
authors.forename: Antoine
authors.initials: A
authors.lastname: Buemi
authors.affiliation: a Department of Internal Medicine , University Hospital of Messina , Messina , Italy .
authors.forename: Valeria
authors.initials: V
authors.lastname: Cernaro
authors.affiliation: e Department of Neuroscience , University Hospital of Messina , Messina , Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Noto
authors.affiliation: a Department of Internal Medicine , University Hospital of Messina , Messina , Italy .
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Pettinato
authors.affiliation: a Department of Internal Medicine , University Hospital of Messina , Messina , Italy .
authors.forename: Domenico
authors.initials: D
authors.lastname: Santoro
authors.affiliation: a Department of Internal Medicine , University Hospital of Messina , Messina , Italy .
authors.forename: Tullio
authors.initials: T
authors.lastname: Bertani
authors.affiliation: a Department of Internal Medicine , University Hospital of Messina , Messina , Italy .
authors.forename: Michele
authors.initials: M
authors.lastname: Buemi
authors.affiliation: e Department of Neuroscience , University Hospital of Messina , Messina , Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: David
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D002908:Chronic Disease; D051799:Delayed Graft Function; D005260:Female; D006801:Humans; D007674:Kidney Diseases; D016030:Kidney Transplantation / Q000009:adverse effects*; D000071068:Lipocalin-2 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve
chemical_list: D015415:Biomarkers; C489506:LCN2 protein, human; D000071068:Lipocalin-2
keywords: Biomarker; chronic allograft nephropathy; delayed graft function; kidney transplantation; long-term graft failure; neutrophil gelatinase associated lipocalin