title: Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral Cochleostomy.
abstract: Dizziness and vertigo frequently occur after cochlear implantation (CI) surgery, particularly during the early stages. It could recover over time but some of the patients suffered from delayed or sustained vestibular symptoms after CI. This study used rat animal models to investigate the effect of unilateral cochleostomy on the vestibular organs over time. Twenty-seven Sprague Dawley rats underwent cochleostomy to evaluate the postoperative changes in hearing threshold, gain and symmetry of the vestibular ocular response, overall balance function, number of hair cells in the crista, and the c-Fos activity in the brainstem vestibular nucleus. Loss of vestibular function was observed during the early stages, but function recovered partially over time. Histopathological findings demonstrated a mild decrease in vestibular hair cells numbers. Increased c-Fos immunoreactivity in the vestibular nucleus, observed in the early stages after cochleostomy, decreased over time. Cochleostomy is a risk factor for peripheral vestibular organ damage that can cause functional impairment in the peripheral vestibular organs. Altered vestibular nucleus activity may be associated with vestibular compensation and plasticity after unilateral cochleostomy.
authors.affiliation: Department of Otorhinolaryngology, Seoul National University Hospital, Seoul 03080, Republic of Korea.
authors.forename: Myung-Whan
authors.initials: MW
authors.lastname: Suh
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Dankook University Hospital, Cheonan 31116, Republic of Korea.
authors.forename: Jaihwan
authors.initials: J
authors.lastname: Hyun
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.
authors.forename: Ah-Ra
authors.initials: AR
authors.lastname: Lyu
authors.affiliation: Department of Anatomy, College of Medicine, Chungnam National University, Daejeon 34134, Republic of Korea; Brain Research Institute, College of Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.
authors.forename: Dong Woon
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.
authors.forename: Sung Jae
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.
authors.forename: Jin Woong
authors.initials: JW
authors.lastname: Choi
authors.affiliation: Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.
authors.forename: Gang Min
authors.initials: GM
authors.lastname: Hur
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon 34134, Republic of Korea; Brain Research Institute, College of Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.
authors.forename: Yong-Ho
authors.identifier: 0000-0003-2106-3791
authors.initials: YH
authors.lastname: Park
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D003051:Cochlea / Q000601:surgery*; D016057:Evoked Potentials, Auditory, Brain Stem; D018069:Hair Cells, Vestibular / Q000473:pathology; D008297:Male; D009473:Neuronal Plasticity; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D045442:Rotarod Performance Test; D014726:Vestibular Nuclei / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D016760:Proto-Oncogene Proteins c-fos