title: Association of the p53 orGSTM1polymorphism with the risk of nasopharyngeal carcinoma: A meta-analysis.
abstract: p53 and glutathione S-transferase M1 (GSTM1) are the most popular suppressor genes. Several previous studies demonstrated positive associations of these gene polymorphisms with numerous cancer types, including hepatocellular cancer, while the association between p53/GSTM1polymorphisms and the nasopharyngeal carcinoma (NPC) risk was inconsistent and underpowered. However, no studies investigating the combinational effect of these two genes on NPC risk were performed. To confirm the effects of p53 andGSTM1polymorphisms on the risk of NPC, a meta-analysis of all the available previous studies associating p53 andGSTM1with the risk of NPC was performed. A comprehensive search of PubMed, Web of Science and SD database until November 2014 was performed to identify the relevant studies. The data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Meta-regression and subgroup analyses were performed to identify the source of heterogeneity. Finally, five studies with 1,419 cases and 1,707 controls were included for the p53 polymorphism and three studies with 837 cases and 1,299 controls were included for theGSTM1polymorphism. Regarding p53, a significantly increased NPC risk was observed in the overall population (C vs. G, OR, 1.245; 95% CI, 1.045-1.483; P=0.014; additive models: CC vs. GG, OR, 1.579; 95% CI, 1.100-2.265; P=0.013 and CG vs. GG, OR, 1.230; 95% CI, 1.039-1.456; P=0.016; dominant model, OR, 1.321; 95% CI, 1.127-1.549; P=0.001; recessive model, OR, 1.429; 95% CI, 1.017-2.009; P=0.040). ConcerningGSTM1, a significantly increased NPC risk was observed in the overall population (null versus non-null, OR, 1.282; 95% CI, 1.075-1.530; P=0.006). In the subgroup analyses stratified by the source of controls, a significant association of p53 with NPC risk was also demonstrated, while no association withGSTM1was observed. Therefore, the p53 G72C polymorphism may have a susceptible role in the carcinogenesis of NPC, while genetic deletion ofGSTM1may contribute to increased susceptibility to NPC. Further large and well-designed studies are required to confirm this association.
authors.affiliation: Department of Oncology, The Fifth People's Hospital of Wuhu, Wuhu, Anhui 241000, P.R. China.
authors.forename: Muyun
authors.initials: M
authors.lastname: Wu
authors.affiliation: Department of Oncology, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Shujing
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Internal Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Oncology, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Miao
authors.initials: M
authors.lastname: Peng
authors.affiliation: Department of Oncology, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Oncology, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Xicheng
authors.initials: X
authors.lastname: Wang
keywords: GSTM1; meta-analysis; nasopharyngeal carcinoma; p53; polymorphism