title: Klotho connects intermedin1-53 to suppression of vascular calcification in chronic kidney disease.
abstract: Vascular calcification is one of the leading causes of death in chronic kidney disease (CKD) patients. Klotho protein encoded by the anti-aging gene, Klotho, and intermedin1-53 have both been shown to protect the vasculature from calcification in CKD. The study by Chang and colleagues links Klotho and intermedin1-53 in prevention of vascular calcification in CKD by showing that intermedin1-53 increased renal, vascular, and plasma Klotho, and reduced vascular calcification in CKD rats. Intermedin1-53 may be a novel therapeutic agent for CKD.
authors.affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address: ming-chang.hu@utsouthwestern.edu.
authors.forename: Ming Chang
authors.initials: MC
authors.lastname: Hu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood*; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000628:therapy; D061205:Vascular Calcification / Q000378:metabolism
chemical_list: D015415:Biomarkers; D005346:Fibroblast Growth Factors