title: Modulation of Toll-like receptor signaling in innate immunity by natural products.
abstract: For centuries, natural products and their derivatives have provided a rich source of compounds for the development of new immunotherapies in the treatment of human disease. Many of these compounds are currently undergoing clinical trials, particularly as anti-oxidative, anti-microbial, and anti-cancer agents. However, the function and mechanism of natural products in how they interact with our immune system has yet to be extensively explored. Natural immune modulators may provide the key to control and ultimately defeat disorders affecting the immune system. They can either up- or down-regulate the immune response with few undesired adverse effects. In this review, we summarize the recent advancements made in utilizing natural products for immunomodulation and their important molecular targets, members of the Toll-like receptor (TLR) family, in the innate immune system.
authors.affiliation: Medical Scientist Training Program, The Ohio State University, Columbus, OH, USA.
authors.forename: Luxi
authors.initials: L
authors.lastname: Chen
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA; The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital & Solove Research Center, Columbus, OH, USA. Electronic address: jianhua.yu@osumc.edu.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yu
mesh_terms: D001688:Biological Products / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D005227:Fatty Acids / Q000494:pharmacology; D006801:Humans; D007107:Immune System / Q000187:drug effects* / Q000378:metabolism; D007113:Immunity, Innate / Q000187:drug effects*; D007155:Immunologic Factors / Q000494:pharmacology*; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D008519:Medicine, Traditional / Q000379:methods; D028321:Plant Preparations / Q000494:pharmacology; D019936:Probiotics / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects*; D051193:Toll-Like Receptors / Q000378:metabolism*
chemical_list: D001688:Biological Products; D005227:Fatty Acids; D007155:Immunologic Factors; D028321:Plant Preparations; D051193:Toll-Like Receptors
keywords: Immunomodulation; Innate immunity; Natural products; TLRs