title: Prospective evaluation of Peristeen® transanal irrigation system with the validated neurogenic bowel dysfunction score sheet in the pediatric population.
abstract: To determine the ability of Peristeen® transanal irrigation system to reduce symptoms of neurogenic bowel dysfunction (NBD) in patients using the validated neurogenic bowel dysfunction scoring system for the pediatric population.
  
  
  
  Patients 3-21 years with NBD whose current bowel program was unsuccessful were given the Neurogenic Bowel Dysfunction (NBoDS) score sheet before initiating Peristeen®, and at 2 weeks, 2 months, and 6 months after. All patients were started on Peristeen® with tap water (20 ml/kg) per daily irrigation. Mean and paired t-tests were completed.
  
  
  
  24 patients were enrolled and had follow-up. Mean age was 10.5 years (range 3-21 years), 25%, 50%, 25% had thoracic, lumbar and sacral level lesions respectively. Mean NBoDS score at initiation of Peristeen® was 20.21 (±5.56), n = 24. The mean score after two weeks of use was 12.75 (±4.40), n = 24. There was a statistically significant decrease of 7.46 (95%CI, 5.07-9.84) points, t(23) = 6.47, P < 0.0005 after two weeks. There was a statistically significant decrease in their scores from initiation to the 2 month time period of 7.00 (95%CI, 2.18-11.82) points, t(9) = 3.29, P = 0.009. By the sixth month of daily use the mean NBoDS score was 9.67 (n = 12). This was an average decrease of 8.83 (95%CI, 5.39-12.28) points from initiation score, t(11) = 5.641, P < 0.005.
  
  
  
  The Peristeen® transanal irrigation system provides a significant reduction in NBoDS scores in pediatric patients with NBD. Peristeen® should be considered when other conservative bowel management options have been unsuccessful. Neurourol. Urodynam. 36:632-635, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Urology, Duke University Medical Center, Durham, North Carolina.
authors.forename: Maryellen S
authors.initials: MS
authors.lastname: Kelly
authors.affiliation: Children's Hospital of Orange County, Pediatric Urology Center, Orange, California.
authors.forename: Crystal
authors.initials: C
authors.lastname: Dorgalli
authors.affiliation: Children's Hospital of Orange County, Pediatric Urology Center, Orange, California.
authors.forename: Gordon
authors.initials: G
authors.lastname: McLorie
authors.affiliation: Children's Hospital of Orange County, Pediatric Urology Center, Orange, California.
authors.forename: Antoine E
authors.initials: AE
authors.lastname: Khoury
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007422:Intestines / Q000503:physiopathology*; D008297:Male; D055496:Neurogenic Bowel / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D007507:Therapeutic Irrigation; D016896:Treatment Outcome; D055815:Young Adult
keywords: neurogenic bowel; neurogenic bowel dysfunction score; peristeen; spina bifida; transanal irrigation