title: Myricetin: A Dietary Molecule with Diverse Biological Activities.
abstract: Myricetin is a common plant-derived flavonoid and is well recognised for its nutraceuticals value. It is one of the key ingredients of various foods and beverages. The compound exhibits a wide range of activities that include strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities. It displays several activities that are related to the central nervous system and numerous studies have suggested that the compound may be beneficial to protect against diseases such as Parkinson's and Alzheimer's. The use of myricetin as a preserving agent to extend the shelf life of foods containing oils and fats is attributed to the compound's ability to protect lipids against oxidation. A detailed search of existing literature revealed that there is currently no comprehensive review available on this important molecule. Hence, the present work includes the history, synthesis, pharmaceutical applications and toxicity studies of myricetin. This report also highlights structure-activity relationships and mechanisms of action for various biological activities.
authors.affiliation: Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria 0001, South Africa. SemwalDK@tut.ac.za.
authors.forename: Deepak Kumar
authors.initials: DK
authors.lastname: Semwal
authors.affiliation: Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria 0001, South Africa. SemwalRB@tut.ac.za.
authors.forename: Ruchi Badoni
authors.initials: RB
authors.lastname: Semwal
authors.affiliation: Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria 0001, South Africa. CombrinckS@tut.ac.za.|SAMRC Herbal Drugs Research Unit, Faculty of Science, Tshwane University of Technology, Pretoria 0001, South Africa. CombrinckS@tut.ac.za.
authors.forename: Sandra
authors.initials: S
authors.lastname: Combrinck
authors.affiliation: Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria 0001, South Africa. viljoenam@tut.ac.za.|SAMRC Herbal Drugs Research Unit, Faculty of Science, Tshwane University of Technology, Pretoria 0001, South Africa. viljoenam@tut.ac.za.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Viljoen
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D004032:Diet; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D009422:Nervous System Diseases / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010945:Plants, Edible / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D005419:Flavonoids; D018696:Neuroprotective Agents; D010936:Plant Extracts; C040015:myricetin
keywords: anti-HIV activity; anti-alzheimer activity; anti-oxidant activity; cytotoxicity; myricetin; polyphenol