title: Granuloma Due to Oxidized Regenerated Cellulose in an Aged Rhesus Macaque (Macaca mulatta).
abstract: Bioabsorbable hemostatic agents such as oxidized regenerated cellulose are widely used to control intraoperative diffuse capillary bleeding. Compared with electrocautery or ligation, oxidized regenerated cellulose has the advantage of controlling bleeding without occluding the vessel lumen or causing thermal injuries to adjacent tissue. Although the manufacturer recommends removal of the material once hemostasis is achieved, oxidized regenerated cellulose is a bioabsorbable hemostatic agent and is often left in the surgical bed to prevent subsequent bleeding after surgical closure. However, noninvasive imaging techniques have revealed granulomatous foreign-body reactions that mimic infection or tumor recurrence. We present a case report of sterile peritonitis and granuloma formation secondary to the presence of oxidized regenerated cellulose after intestinal resection to excise a colonic adenocarcinoma in an aged rhesus macaque.
authors.affiliation: Department of Primate Medicine, California National Primate Research Center, University of California, Davis, California, USA. mjlemoy@primate.ucdavis.edu.
authors.forename: Marie-Josee Mf
authors.initials: MJ
authors.lastname: Lemoy
authors.affiliation: Department of Primate Medicine, California National Primate Research Center, University of California, Davis, California, USA.
authors.forename: Angela Colagross
authors.initials: AC
authors.lastname: Schouten
authors.affiliation: Department of Pathology, California National Primate Research Center, University of California, Davis, California, USA.
authors.forename: Don R
authors.initials: DR
authors.lastname: Canfield
mesh_terms: D000367:Age Factors; D000818:Animals; D001706:Biopsy / Q000662:veterinary; D002482:Cellulose / Q000009:adverse effects*; D003082:Colectomy / Q000662:veterinary*; D015745:Granuloma, Foreign-Body / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D006489:Hemostatic Techniques / Q000009:adverse effects*; D008253:Macaca mulatta; D008992:Monkey Diseases / Q000175:diagnosis / Q000209:etiology*; D010084:Oxidation-Reduction; D010538:Peritonitis / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D011860:Radiography, Abdominal / Q000662:veterinary
chemical_list: D002482:Cellulose; C012024:rayon, purified