title: Evaluation of lipid profiles in patients with metabolic syndrome according to cardiovascular risk calculated on the basis of the SCORE chart.
abstract: BACKGROUND
  Metabolic syndrome predicts the development of CVD. Lipid abnormalities probably have an important influence on the increase of cardiovascular death risk. The SCORE chart includes only total cholesterol level, which may be inadequate. The aim of our study was to evaluate the lipid profile in patients with metabolic syndrome according to the cardiovascular risk calculated on the basis of the SCORE chart.
  
  
  METHODS
  The study participants comprised 974 patients with metabolic syndrome. The 10-year death risk of cardiovascular disease was calculated on the basis of SCORE chart in all patients. The study group was divided in three subgroups depending on the risk level calculated by SCORE scale.
  
  
  RESULTS
  There was a significantly higher level of LDL-C fraction in the subgroup of very high CV risk in comparison to the group of medium and high CV risk. The level of non-HDL-C was also significantly higher in the group with SCORE ≥ 10 compared to the remaining subgroups of medium and high CV risk.
  
  
  CONCLUSIONS
  Increased CV risk in this group of patients may be associated not only with higher TC level, but also the other lipid fractions. The assessment of the CV risk on the basis of the SCORE chart, which includes only TC level, may be inadequate. A modification of the SCORE chart for the European population should be considered (inclusion of LDL-C level, or in selected cases non-HDL-C level instead of TC level). (Endokrynol Pol 2016; 67 (3): 265-270).
authors.affiliation: Department of Endocrinology and Diabetology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland Internal Ward, Hospital in Wąbrzeźno, Poland. marcin_gierach@wp.pl.
authors.forename: Marcin
authors.initials: M
authors.lastname: Gierach
authors.forename: Joanna
authors.initials: J
authors.lastname: Gierach
authors.forename: Roman
authors.initials: R
authors.lastname: Junik
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology* / Q000401:mortality; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D008055:Lipids
keywords: SCORE chart; cardiovascular risk; metabolic syndrome