title: Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease.
abstract: Genome-wide association studies and candidate gene studies have informed our understanding of factors contributing to the well-recognized interindividual variation in the progression and outcomes of alcoholic liver disease and nonalcoholic fatty liver disease. We discuss the mounting evidence for shared modifiers and common pathophysiological processes that contribute to development of both diseases. We discuss the functions of proteins encoded by risk variants of genes including patatin-like phospholipase domain-containing 3 and transmembrane 6 superfamily member 2, as well as epigenetic factors that contribute to the pathogenesis of alcoholic liver disease and nonalcoholic fatty liver disease. We also discuss important areas of future genetic research and their potential to affect clinical management of patients.
authors.affiliation: Liver Research Group, Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom. Electronic address: quentin.anstee@ncl.ac.uk.
authors.forename: Quentin M
authors.initials: QM
authors.lastname: Anstee
authors.affiliation: Centenary Institute of Cancer Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; Drug Health Services, Royal Prince Alfred Hospital, Camperdown, Australia; Central Clinical School, The University of Sydney, Camperdown, Australia.
authors.forename: Devanshi
authors.initials: D
authors.lastname: Seth
authors.affiliation: Liver Research Group, Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom.
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Day
mesh_terms: D005235:Fatty Liver, Alcoholic / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000235:genetics*; D012307:Risk Factors
keywords: ALD; Cirrhosis; Gene; NAFLD; PNPLA3; TM6SF2