title: Synthesis and Anti-Inflammatory Activity of Some O-Propargylated-N-acetylpyrazole Derived from 1,3-Diarylpropenones.
abstract: In search of novel effective potent therapeutic agents delivered by oral route for inflammation treatment, some novel O-propargylated-N-acetylpyrazole analogs (5a-j) were prepared by treating N-acetylpyrazole (4a-j) derived from 1,3-diarylpropenones (3a-j) with propargyl bromide. Claisen-Schmidt condensation of a series of substituted aryl ketones 1 and benzaldehydes 2 in glacial acetic acid afforded 1,3-diarylpropenones which on further treatment with hydrazine hydrate in acetic acid under reflux conditions afforded 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles (4a-j). The products were characterized by using spectroscopic techniques such as IR and NMR. In addition, the in vivo anti-inflammatory activity of the synthesized compounds was determined using the carrageenan-induced paw oedema method in rats.
authors.affiliation: Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana 135001, India; Department of Pharmacy, IK Gujral Punjab Technical University, Jalandhar, Punjab 144601, India.
authors.forename: Ashwani Kumar
authors.initials: AK
authors.lastname: Dhingra
authors.affiliation: Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana 135001, India; Department of Pharmacy, IK Gujral Punjab Technical University, Jalandhar, Punjab 144601, India.
authors.forename: Bhawna
authors.initials: B
authors.lastname: Chopra
authors.affiliation: Department of Industrial Chemistry, Guru Nanak Khalsa College, Yamuna Nagar, Haryana 135001, India.
authors.forename: Rameshwar
authors.initials: R
authors.lastname: Dass
authors.affiliation: IEC School of Pharmacy, IEC University, Baddi, Himachal Pradesh 173205, India.
authors.forename: Sanjeev K
authors.initials: SK
authors.lastname: Mittal