title: Plasma pentraxin-3 levels in patients with Takayasu's arteritis during routine follow-up.
abstract: OBJECTIVE
  To date, no biomarker is universally accepted to be a surrogate for active disease being one of major difficulties in follow-up of Takayasu's arteritis (TAK). In this study, we aimed to investigate plasma pentraxin-3 (PTX-3) levels and its correlation with activity in patients with TAK.
  
  
  METHODS
  This cross-sectional study included 94 patients (age: 43.3±13.6 years, F/M: 80/14) with TAK, 40 age-sex matched control donors (age: 41.5±9.3 years, F/M: 28/12). TAK patients were evaluated by physician's global assessment (PGA; active/inactive), as well as with the activity definition by Kerr et al. and with a new composite index of ITAS2010 (Indian Takayasu Clinical Activity Score). Plasma PTX-3 levels are measured with an enzyme linked immunosorbent assay kit.
  
  
  RESULTS
  Thirty-three (35.5%) patients were clinically active with PGA, while 25 (31.6%) patients and 28 (31.8%) patients were accepted to have active disease according to Kerr activity criteria and ITAS2010, respectively. Plasma PTX-3 levels were significantly higher in TAK patients compared to healthy controls (3.5±2.5 ng/ml vs. 2.5±1.6 ng/ ml, p=0.029). However, PTX-3 levels were similar among active and inactive patients according to all three assessment tools. PTX-3 levels significantly correlated only with serum CRP levels.
  
  
  CONCLUSIONS
  Although plasma PTX- 3 levels were higher in patients with TAK compared to healthy controls, we observed no association with disease activity, limiting the role of PTX-3 level as a biomarker for active disease in TAK.
authors.affiliation: Marmara University, School of Medicine, Division of Rheumatology, Istanbul, Turkey. falibaz@gmail.com.
authors.forename: Fatma
authors.initials: F
authors.lastname: Alibaz-Oner
authors.affiliation: Ege University, School of Medicine, Division of Rheumatology, Izmir, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Aksu
authors.affiliation: Istanbul University, Istanbul Medical Faculty, Department of Physiology, Istanbul, Turkey.
authors.forename: Sibel P
authors.initials: SP
authors.lastname: Yentur
authors.affiliation: Ege University, School of Medicine, Division of Rheumatology, Izmir, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Keser
authors.affiliation: Istanbul University, Istanbul Medical Faculty, Department of Physiology, Istanbul, Turkey.
authors.forename: Güher
authors.initials: G
authors.lastname: Saruhan-Direskeneli
authors.affiliation: Marmara University, School of Medicine, Division of Rheumatology, Istanbul, Turkey.
authors.forename: Haner
authors.initials: H
authors.lastname: Direskeneli
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D000683:Serum Amyloid P-Component / Q000032:analysis*; D013625:Takayasu Arteritis / Q000097:blood*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins