title: Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies.
abstract: The field of mitochondrial epigenetics has received increased attention in recent years and changes in mitochondrial DNA (mtDNA) methylation has been implicated in a number of diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis. However, current publications have been limited by the use of global or targeted methods of measuring DNA methylation. In this review, we discuss current findings in mitochondrial epigenetics as well as its potential role as a regulator of mitochondria within the brain. Finally, we summarize the current technologies best suited to capturing mtDNA methylation, and how a move towards whole epigenome sequencing of mtDNA may help to advance our current understanding of the field.
authors.affiliation: Institute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Devon, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Devall
authors.affiliation: Institute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Devon, UK; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHENS), Maastricht University, Maastricht, The Netherlands.
authors.forename: Janou
authors.initials: J
authors.lastname: Roubroeks
authors.affiliation: Institute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Devon, UK; Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, De Crespigny Park, London, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Mill
authors.affiliation: Institute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Devon, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Weedon
authors.affiliation: Institute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Devon, UK. Electronic address: k.lunnon@exeter.ac.uk.
authors.forename: Katie
authors.initials: K
authors.lastname: Lunnon
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D019175:DNA Methylation; D004272:DNA, Mitochondrial / Q000235:genetics*; D044127:Epigenesis, Genetic; D057890:Epigenomics / Q000379:methods*; D005786:Gene Expression Regulation; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D004272:DNA, Mitochondrial
keywords: AD; Alzheimer's disease; DNA methylation; Epigenetics; Mitochondria; mtDNA