title: Pancreatic neuroendocrine tumors in twelve baboons (Papio spp.).
abstract: BACKGROUND
  Pancreatic neuroendocrine tumors (PNETs) are rare in nonhuman primates and in humans.
  
  
  METHODS
  Twenty-one PNETs from twelve female baboons (Papio spp.) from the Southwest National Primate Research Center were evaluated using histopathology and immunohistochemistry.
  
  
  RESULTS
  Histologically, all tumors were benign and had neuroendocrine packeting. Immunohistochemical staining for synaptophysin and chromogranin was positive in all tumors evaluated (17/17). Insulin was positive in 16 of 21 tumors. Somatostatin was positive in 9 of 20 tumors. Multifocal staining for glucagon and pancreatic polypeptide was evident in a minority of tumors (6/20 and 2/17, respectively). Gastrin and vasoactive intestinal peptide were negative in all tumors evaluated. Nine tumors expressed more than one hormone marker.
  
  
  CONCLUSIONS
  This is the first detailed pathologic study of pancreatic endocrine tumors in the baboon. The findings suggest that these tumors are generally benign and have similar morphologic and immunohistochemical features as those described in people, including the ability to express multiple hormones.
authors.affiliation: Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Owston
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: LaRue
authors.affiliation: Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Dick
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: A
authors.initials: A
authors.lastname: Ambrus
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: B F
authors.initials: BF
authors.lastname: Porter
mesh_terms: D000818:Animals; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008992:Monkey Diseases / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D010215:Papio
keywords: chromogranin; endocrine; glucagon; immunohistochemistry; insulin; neoplasia; nonhuman-primate; pancreas; somatostatin; synaptophysin