title: Improved delivery of poorly soluble compounds using nanoparticle technology: a review.
abstract: Although a large number of new drug molecules with varied therapeutic potentials have been discovered in the recent decade, yet most of them are still in developmental process. This can be attributed to the limited aqueous solubility which governs the bioavailability of such drug molecules. Hence, there is a requisite for a technology-based product (formulation) in order to overcome such issues without compromising on the therapeutic response. The purpose of this review is to provide an insight to the formulation of drug nanoparticles for enhancing solubility and dissolution velocity with concomitant enhancement in bioavailability. In the recent decade, nanonization has evolved from a concept to reality owing to its versatile applications, especially in the development of drugs having poor solubility. In this review, a relatively simple and scalable approach for the manufacture of drug nanoparticles and latest characterization techniques utilized to evaluate the drug nanoparticles are discussed. The drug nanoparticulate approach described herein provides a general applicability of the platform technology in designing a formulation for drugs associated with poor aqueous solubility.
authors.affiliation: Department of Pharmaceutical Technology, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh, India. kalepu_sandeep3@yahoo.co.in.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Kalepu
authors.affiliation: College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA.
authors.forename: Vijaykumar
authors.initials: V
authors.lastname: Nekkanti
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D053758:Nanoparticles; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
keywords: Dissolution rate; Drug nanoparticles; Homogenization; Particle size; Solid intermediate