title: Hemorheological parameters better classify metabolic syndrome than novel cardiovascular risk factors and peripheral vascular disease marker.
abstract: The present study compares the association of Metabolic Syndrome (MetS) with hemorheological parameters, oxidative stress, inflammation and peripheral arterial disease markers. 100 participants were recruited and participants were divided into three groups on the basis of absence or presence of MetS and its components. Odds ratio for correctly predicting MetS was highest for erythrocyte aggregation followed by erythrocyte deformability. ROC curve analysis demonstrated that all the hemorheological components significantly classified MetS participants. Area Under Curve was higher for the hemorheological parameters (erythrocyte aggregation and erythrocyte deformability) than for the oxidative stress, inflammation and peripheral arterial disease markers. The possibilities of the hemorheological components to be identified as better cardiovascular risk markers due to their strong association with MetS cannot be precluded from the present findings.
authors.affiliation: Biomedical Sciences, School of Community Health, Charles Sturt University, NSW, Australia.
authors.forename: Prajwal
authors.initials: P
authors.lastname: Gyawali
authors.affiliation: Biomedical Sciences, School of Community Health, Charles Sturt University, NSW, Australia.
authors.forename: Ross S
authors.initials: RS
authors.lastname: Richards
authors.affiliation: Podiatry, Charles Sturt University, NSW, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Tinley
authors.affiliation: School of Community Health, Charles Sturt University, NSW, Australia.
authors.forename: Ezekiel Uba
authors.initials: EU
authors.lastname: Nwose
authors.affiliation: School of Biomedical Sciences, Charles Sturt University, NSW, Australia.
authors.forename: Phillip T
authors.initials: PT
authors.lastname: Bwititi
mesh_terms: D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases; D018056:Hemorheology; D006801:Humans; D007249:Inflammation; D024821:Metabolic Syndrome / Q000097:blood*; D018384:Oxidative Stress; D058729:Peripheral Arterial Disease / Q000097:blood*; D012307:Risk Factors
chemical_list: D015415:Biomarkers
keywords: Hemorheology; ROC curve; inflammation; oxidative stress