title: Stem Cell Therapy for Treatment of Stress Urinary Incontinence: The Current Status and Challenges.
abstract: Stress urinary incontinence (SUI) is a common urinary system disease that mostly affects women. Current treatments still do not solve the critical problem of urethral sphincter dysfunction. In recent years, there have been major developments in techniques to obtain, culture, and characterize autologous stem cells as well as many studies describing their applications for the treatment of SUI. In this paper, we review recent publications and clinical trials investigating the applications of several stem cell types as potential treatments for SUI and the underlying challenges of such therapy.
authors.affiliation: Department of Urology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Shukui
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Urology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Kaile
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Atala
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA.
authors.forename: Oula
authors.initials: O
authors.lastname: Khoury
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA.
authors.forename: Sean V
authors.initials: SV
authors.lastname: Murphy
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA.
authors.forename: Weixin
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Urology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu