title: Fluorescent supramolecular micelles for imaging-guided cancer therapy.
abstract: A novel smart fluorescent drug delivery system composed of a perylene diimide (PDI) core and block copolymer poly(d,l-lactide)-b-poly(ethyl ethylene phosphate) is developed and named as PDI-star-(PLA-b-PEEP)8. The biodegradable PDI-star-(PLA-b-PEEP)8 is a unimolecular micelle and can self-assemble into supramolecular micelles, called as fluorescent supramolecular micelles (FSMs), in aqueous media. An insoluble drug camptothecin (CPT) can be effectively loaded into the FSMs and exhibits pH-responsive release. Moreover, the FSMs with good biocompatibility can also be employed as a remarkable fluorescent probe for cell labelling because the maximum emission of PDI is beneficial for bio-imaging. The flow cytometry and confocal laser scanning microscopy analysis demonstrate that the micelles are easily endocytosed by cancer cells. In vitro and in vivo tumor growth-inhibitory studies reveal a better therapeutic effect of FSMs after CPT encapsulation when compared with the free CPT drug. The multifunctional FSM nanomedicine platform as a nanovehicle has great potential for fluorescence imaging-guided cancer therapy.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 100029, Beijing, China. yinmz@mail.buct.edu.cn.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Sun
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics, Chinese Academy of Sciences, 100049, Beijing, China. yinwy@ihep.ac.cn.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Yin
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics, Chinese Academy of Sciences, 100049, Beijing, China. yinwy@ihep.ac.cn.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Dong
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 100029, Beijing, China. yinmz@mail.buct.edu.cn.
authors.forename: Wantai
authors.initials: W
authors.lastname: Yang
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics, Chinese Academy of Sciences, 100049, Beijing, China. yinwy@ihep.ac.cn.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 100029, Beijing, China. yinmz@mail.buct.edu.cn.
authors.forename: Meizhen
authors.initials: M
authors.lastname: Yin
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007094:Imides / Q000737:chemistry / Q000494:pharmacology; D008807:Mice, Inbred BALB C; D008823:Micelles; D050997:Nanomedicine; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000628:therapy*; D061848:Optical Imaging / Q000379:methods*; D010569:Perylene / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology
chemical_list: D005456:Fluorescent Dyes; D007094:Imides; D008823:Micelles; D011091:Polyesters; C521332:perylenediimide; C033616:poly(lactide); D010569:Perylene