title: Elimination and Concentration Correlations between Edible Tissues and Biological Fluids and Hair of Ractopamine in Pigs and Goats Fed with Ractopamine-Medicated Feed.
abstract: Ractopamine (RAC), a β-adrenergic leanness-enhancing agent, endangers the food safety of animal products because of overdosing and illegal use in food animals. Excretion and residue depletion of RAC in pigs and goats were investigated to determine a representative biological fluid or surface tissue for preslaughter monitoring. After a single oral gavage of RAC, 64-67% of the dose was excreted from the urine of pigs and goats within 12-24 h. RAC persisted the longest in the hair of pigs and goats but depleted rapidly in the plasma, muscle, and fat. Urine and hair were excellent for predicting RAC residues in edible tissues of pigs, whereas plasma and urine were satisfactory body fluids for the prediction of RAC concentrations in edible tissues of goats. These data provided a simple and economical preslaughter living monitoring method for the illegal use and violative residue of RAC in food animals.
authors.affiliation: MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, ‡National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, and §Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University , Wuhan, Hubei 430070, China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Huang
authors.affiliation: MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, ‡National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, and §Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University , Wuhan, Hubei 430070, China.
authors.forename: Jingfei
authors.initials: J
authors.lastname: Shi
authors.affiliation: MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, ‡National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, and §Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University , Wuhan, Hubei 430070, China.
authors.forename: Yuanhu
authors.initials: Y
authors.lastname: Pan
authors.affiliation: MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, ‡National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, and §Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University , Wuhan, Hubei 430070, China.
authors.forename: Liye
authors.initials: L
authors.lastname: Wang
authors.affiliation: MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, ‡National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, and §Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University , Wuhan, Hubei 430070, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Chen
authors.affiliation: MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, ‡National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, and §Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University , Wuhan, Hubei 430070, China.
authors.forename: Shuyu
authors.initials: S
authors.lastname: Xie
authors.affiliation: MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, ‡National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, and §Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University , Wuhan, Hubei 430070, China.
authors.forename: Zhenli
authors.initials: Z
authors.lastname: Liu
authors.affiliation: MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, ‡National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, and §Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University , Wuhan, Hubei 430070, China.
authors.forename: Zonghui
authors.initials: Z
authors.lastname: Yuan
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000318:Adrenergic beta-Agonists; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001826:Body Fluids / Q000737:chemistry*; D004032:Diet / Q000662:veterinary; D005243:Feces / Q000737:chemistry; D005506:Food Contamination; D006041:Goats; D006197:Hair / Q000737:chemistry*; D008460:Meat / Q000032:analysis*; D009132:Muscles / Q000737:chemistry; D010627:Phenethylamines / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D015203:Reproducibility of Results; D034421:Sus scrofa; D019155:Veterinary Drugs / Q000008:administration & dosage / Q000032:analysis
chemical_list: D000318:Adrenergic beta-Agonists; D010627:Phenethylamines; D019155:Veterinary Drugs; C060897:ractopamine
keywords: correlation; goat; pig; preslaughter monitoring; ractopamine; residue depletion