title: Structure and functions of angiotensinogen.
abstract: Angiotensinogen (AGT) is the sole precursor of all angiotensin peptides. Although AGT is generally considered as a passive substrate of the renin-angiotensin system, there is accumulating evidence that the regulation and functions of AGT are intricate. Understanding the diversity of AGT properties has been enhanced by protein structural analysis and animal studies. In addition to whole-body genetic deletion, AGT can be regulated in vivo by cell-specific procedures, adeno-associated viral approaches and antisense oligonucleotides. Indeed, the availability of these multiple manipulations of AGT in vivo has provided new insights into the multifaceted roles of AGT. In this review, the combination of structural and functional studies is highlighted to focus on the increasing recognition that AGT exerts effects beyond being a sole provider of angiotensin peptides.
authors.affiliation: Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA.|Department of Physiology, University of Kentucky, Lexington, KY, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Cassis
authors.affiliation: Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.
authors.forename: Craig W Vander
authors.initials: CW
authors.lastname: Kooi
authors.affiliation: Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA.|Department of Physiology, University of Kentucky, Lexington, KY, USA.|Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Daugherty
mesh_terms: D000808:Angiotensinogen / Q000737:chemistry / Q000235:genetics / Q000493:pharmacokinetics; D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism; D001794:Blood Pressure; D017124:Conserved Sequence; D005234:Fatty Liver / Q000378:metabolism; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009765:Obesity / Q000378:metabolism; D012083:Renin / Q000235:genetics / Q000493:pharmacokinetics; D012084:Renin-Angiotensin System / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D000808:Angiotensinogen; D012083:Renin