title: Mesothelioma with superior vena cava obstruction in young female following short latency of asbestos exposure.
abstract: An 18 years female was admitted with right-sided chest pain, dry cough, and low-grade fever and weight loss for last 1 month. On examination, patient had features of superior vena cava (SVC) syndrome with right-sided pleural effusion. Chest X-ray showed mediastinal widening with nonhomogenous opacity mainly in the periphery of right upper and mid zone with right-sided pleural effusion. Ultrasonography thorax confirmed mild pleural effusion. Pleural fluid analysis showed lymphocytic, exudative, low adenosine deaminase with negative for Pap smear. Contrast-enhanced computed tomography (CT) thorax revealed large extensive nodular soft tissue lesion along right mediastinum as well as costal pleura, with enlarged pretracheal lymphadenopathy and SVC obstruction. CT guided Tru-cut biopsy report came as malignant epithelial tumor with polygonal shape, abundant eosinophilic cytoplasm and nuclei with prominent nucleoli suggestive of mesothelioma of epithelioid type. The tumor cell expressed calretinin, WT-1, and immunonegative for thyroid transcription factor-1.
authors.affiliation: Department of Pulmonary Medicine, R. G. Kar Medical College, Kolkata, West Bengal, India.
authors.forename: Anupam
authors.initials: A
authors.lastname: Patra
authors.forename: Susmita
authors.initials: S
authors.lastname: Kundu
authors.forename: Amitava
authors.initials: A
authors.lastname: Pal
authors.forename: Sayantan
authors.initials: S
authors.lastname: Saha
mesh_terms: D000293:Adolescent; D001194:Asbestos / Q000009:adverse effects*; D002273:Carcinogens / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008654:Mesothelioma / Q000139:chemically induced / Q000473:pathology*; D010996:Pleural Effusion; D010997:Pleural Neoplasms / Q000139:chemically induced / Q000473:pathology*; D013479:Superior Vena Cava Syndrome / Q000139:chemically induced / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D002273:Carcinogens; D001194:Asbestos