title: L1CAM Expression is Related to Non-Endometrioid Histology, and Prognostic for Poor Outcome in Endometrioid Endometrial Carcinoma.
abstract: The majority of endometrial carcinomas are classified as Type I endometrioid endometrial carcinomas (EECs) and have a good prognosis. Type II non-endometrioid endometrial carcinomas (NEECs) have a significant worse outcome. Yet, 20 % of the EECs are associated with an unexplained poor outcome. The aim of this study was to determine if L1CAM expression, a recently reported biomarker for aggressive tumor behavior in endometrial carcinoma, was associated with clinicopathological features of EECs. A total of 103 patients diagnosed as EEC at the Radboud University Medical Centre, based on the pathology report were selected. L1CAM status of these tumors was determined, and histologic slides were reviewed by two expert pathologists. L1CAM-positivity was observed in 17 % (18/103). Review of the diagnostic slides revealed that 11 out of these 18 L1CAM-positive tumors (61 %) contained a serous- or mixed carcinoma component that was not initially mentioned in the pathology report. L1CAM-expression was associated with advanced age, poor tumor grade, and lymphovascular space invasion. A worse five year progression free survival rate was observed for patients with L1CAM-positive tumors (55.6 % for the L1CAM-positive group, compared to 83.3 % for the L1CAM-negative group P = 0.01). L1CAM expression carries prognostic value for histologically classified EEC and supports the identification of tumors with a NEEC component.
authors.affiliation: Department of Obstetrics and Gynaecology, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands.
authors.forename: Yvette P
authors.initials: YP
authors.lastname: Geels
authors.affiliation: Department of Obstetrics and Gynaecology, Elisabeth-TweeSteden Hospital, P.O. Box 90107, 5000 LA, Tilburg, The Netherlands. H.Pijnenborg@planet.nl.
authors.forename: Johanna M A
authors.initials: JM
authors.lastname: Pijnenborg
authors.affiliation: Department of Obstetrics and Gynaecology, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands.
authors.forename: Bart B M
authors.initials: BB
authors.lastname: Gordon
authors.affiliation: Department of Pathology, Kaplan Medical Centre, Rehovot, Israel.
authors.forename: Mina
authors.initials: M
authors.lastname: Fogel
authors.affiliation: Tumour Immunology Program, D015, German Cancer Research Centre, 69120, Heidelberg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Altevogt
authors.affiliation: Department of Pathology, Hasanuddin University Hospital, Makassar, Indonesia.
authors.forename: Rina
authors.initials: R
authors.lastname: Masadah
authors.affiliation: Department of Pathology, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands.
authors.forename: Johan
authors.initials: J
authors.lastname: Bulten
authors.affiliation: Department of Pathology, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands.|Department of Pathology, McGill University, Montreal, QC, Canada.|Jewish General Hospital, Montreal, QC, Canada.
authors.forename: Léon C
authors.initials: LC
authors.lastname: van Kempen
authors.affiliation: Department of Obstetrics and Gynaecology, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands.
authors.forename: Leon F A G
authors.initials: LF
authors.lastname: Massuger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D018269:Carcinoma, Endometrioid / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D018450:Disease Progression; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D039842:Neural Cell Adhesion Molecule L1 / Q000378:metabolism*; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D039842:Neural Cell Adhesion Molecule L1
keywords: Endometrial carcinoma; Histopathological diagnosis; Immunohistochemistry; L1CAM; Non-endometrioid; Prognostic value