title: Blood Transfusion Strategies for Hemostatic Resuscitation in Massive Trauma.
abstract: Massive transfusion practices were transformed during the 1970s without solid evidence supporting the use of component therapy. A manual literature search was performed for all references to the lethal triad, acute or early coagulopathy of trauma, fresh whole blood, and component transfusion therapy in massive trauma, and damage control resuscitation. Data from recent wars suggest traditional component therapy causes a nonhemostatic resuscitation worsening the propagation of the lethal triad hastening death. These same studies also indicate the advantage of fresh whole blood over component therapy even when administered in a 1:1:1 replacement ratio.
authors.affiliation: School of Nursing, Vanderbilt University, Nashville, TN, USA. Electronic address: caroline.mcgrath@vanderbilt.edu.
authors.forename: Caroline
authors.initials: C
authors.lastname: McGrath
mesh_terms: D016913:Blood Component Transfusion / Q000592:standards*; D006470:Hemorrhage / Q000628:therapy*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D017410:Practice Guidelines as Topic; D012151:Resuscitation / Q000592:standards*; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D006490:Hemostatics
keywords: 1:1:1 component therapy; Hemorrhage; Hemostatic resuscitation; Lethal triad; Massive transfusion protocol; Trauma; Whole blood