title: Discontinuation of antidepressant medication after mindfulness-based cognitive therapy for recurrent depression: randomised controlled non-inferiority trial.
abstract: BACKGROUND
  Mindfulness-based cognitive therapy (MBCT) and maintenance antidepressant medication (mADM) both reduce the risk of relapse in recurrent depression, but their combination has not been studied.
  
  
  OBJECTIVE
  To investigate whether MBCT with discontinuation of mADM is non-inferior to MBCT+mADM.
  
  
  METHODS
  A multicentre randomised controlled non-inferiority trial (ClinicalTrials.gov:NCT00928980). Adults with recurrent depression in remission, using mADM for 6 months or longer (n= 249), were randomly allocated to either discontinue (n= 128) or continue (n= 121) mADM after MBCT. The primary outcome was depressive relapse/recurrence within 15 months. A confidence interval approach with a margin of 25% was used to test non-inferiority. Key secondary outcomes were time to relapse/recurrence and depression severity.
  
  
  RESULTS
  The difference in relapse/recurrence rates exceeded the non-inferiority margin and time to relapse/recurrence was significantly shorter after discontinuation of mADM. There were only minor differences in depression severity.
  
  
  CONCLUSIONS
  Our findings suggest an increased risk of relapse/recurrence in patients withdrawing from mADM after MBCT.
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands marloes.huijbers@radboudumc.nl.
authors.forename: Marloes J
authors.initials: MJ
authors.lastname: Huijbers
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Philip
authors.initials: P
authors.lastname: Spinhoven
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: Spijker
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Henricus G
authors.initials: HG
authors.lastname: Ruhé
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Digna J F
authors.initials: DJ
authors.lastname: van Schaik
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Patricia
authors.initials: P
authors.lastname: van Oppen
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Willem A
authors.initials: WA
authors.lastname: Nolen
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Johan
authors.initials: J
authors.lastname: Ormel
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Willem
authors.initials: W
authors.lastname: Kuyken
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Gert Jan
authors.initials: GJ
authors.lastname: van der Wilt
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Marc B J
authors.initials: MB
authors.lastname: Blom
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Aart H
authors.initials: AH
authors.lastname: Schene
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Rogier
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Donders
authors.affiliation: Marloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Anne E M
authors.initials: AE
authors.lastname: Speckens
mesh_terms: D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D064866:Mindfulness; D012008:Recurrence; D055502:Secondary Prevention / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents