title: Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait.
abstract: Adolescent exposure to cannabinoids enhances the behavioural effects of cocaine, and high novelty-seeking trait predicts greater sensitivity to the conditioned place preference (CPP) induced by this drug. Our aim was to evaluate the influence of novelty-seeking on the effects of adolescent cannabinoid exposure. Adolescent male mice were classified as high or low novelty seekers (HNS and LNS) in the hole-board test. First, we evaluated the CPP induced by the cannabinoid agonist WIN 55212-2 (0.05 and 0.075 mg/kg, i.p.) in HNS and LNS mice. Then, HNS and LNS mice were pretreated i.p. with vehicle, WIN 55212-2 (0.1 mg/kg), or cannabinoid antagonist rimonabant (1 mg/kg) and were subsequently conditioned with WIN 55212-2 (0.05 mg/kg, i.p.) or cocaine (1 or 6 mg/kg, i.p.). Only HNS mice conditioned with the 0.075 mg/kg dose acquired CPP with WIN 55212-2. Adolescent exposure to this cannabinoid agonist increased the rewarding effects of 1 mg/kg of cocaine in both HNS and LNS mice, and in HNS mice it also increased the reinstating effect of a low dose of cocaine. Our results endorse a role for individual differences such as a higher propensity for sensation-seeking in the development of addiction.
authors.affiliation: Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiologia, Facultad de Psicología, Universidad de Valencia, 46010 Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez-Arias
authors.affiliation: Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiologia, Facultad de Psicología, Universidad de Valencia, 46010 Valencia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Roger-Sánchez
authors.affiliation: Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiologia, Facultad de Psicología, Universidad de Valencia, 46010 Valencia, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Vilanova
authors.affiliation: Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiologia, Facultad de Psicología, Universidad de Valencia, 46010 Valencia, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Revert
authors.affiliation: Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiologia, Facultad de Psicología, Universidad de Valencia, 46010 Valencia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Manzanedo
authors.affiliation: Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiologia, Facultad de Psicología, Universidad de Valencia, 46010 Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Miñarro
authors.affiliation: Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiologia, Facultad de Psicología, Universidad de Valencia, 46010 Valencia, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Aguilar
mesh_terms: D000818:Animals; D048588:Benzoxazines / Q000008:administration & dosage*; D063386:Cannabinoid Receptor Agonists / Q000008:administration & dosage*; D003042:Cocaine / Q000008:administration & dosage*; D003214:Conditioning, Classical / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D051379:Mice; D009025:Morpholines / Q000008:administration & dosage*; D009281:Naphthalenes / Q000008:administration & dosage*; D012201:Reward
chemical_list: D048588:Benzoxazines; D063386:Cannabinoid Receptor Agonists; D009025:Morpholines; D009281:Naphthalenes; C070417:(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone; D003042:Cocaine