title: Allomyrina Dichotoma Larvae Regulate Food Intake and Body Weight in High Fat Diet-Induced Obese Mice Through mTOR and Mapk Signaling Pathways.
abstract: Recent evidence has suggested that the Korean horn beetle (Allomyrina dichotoma) has anti-hepatofibrotic, anti-neoplastic, and antibiotic effects and is recognized as a traditional medicine. In our previous works, Allomyrina dichotoma larvae (ADL) inhibited differentiation of adipocytes both in vitro and in vivo. However, the anorexigenic and endoplasmic reticulum(ER) stress-reducing effects of ADL in obesity has not been examined. In this study, we investigated the anorexigenic and ER stress-reducing effects of ADL in the hypothalamus of diet-induced obese (DIO) mice. Intracerebroventricular (ICV) administration of ethanol extract of ADL (ADE) suggested that an antagonizing effect on ghrelin-induced feeding behavior through the mTOR and MAPK signaling pathways. Especially, ADE resulted in strong reduction of ER stress both in vitro and in vivo. These findings strongly suggest that ADE and its constituent bioactive compounds are available and valuable to use for treatment of various diseases driven by prolonged ER stress.
authors.affiliation: Department of Anatomy, Graduate School of Dongguk University College of Medicine, Gyeongju 38066, Korea. kimjw3189@naver.com.
authors.forename: Jongwan
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Agricultural Biology, National Academy of Agricultural Science, RDA, Wanju-gun 55365, Korea. yuney@korea.kr.
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Yun
authors.affiliation: Department of Biotechnology, Catholic University of Daegu, Daegu 38430, Korea. microsw@cu.ac.kr.
authors.forename: Seong-Won
authors.initials: SW
authors.lastname: Park
authors.affiliation: Department of Biochemistry, Dongguk University College of Medicine, Gyeongju 38066, Korea. gootw@dongguk.ac.kr.
authors.forename: Tae-Won
authors.initials: TW
authors.lastname: Goo
authors.affiliation: Department of Agricultural Biology, National Academy of Agricultural Science, RDA, Wanju-gun 55365, Korea. nansmc@hanmail.net.
authors.forename: Minchul
authors.initials: M
authors.lastname: Seo
mesh_terms: D000818:Animals; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects*; D001517:Coleoptera; D059305:Diet, High-Fat; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D007814:Larva; D020935:MAP Kinase Signaling System / Q000187:drug effects*; D008297:Male; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D001688:Biological Products; C546843:mTOR protein, mouse; D058570:TOR Serine-Threonine Kinases
keywords: Allomyrina dichotoma larvae; ER stress; appetite; diet-induced obesity; hypothalamus