title: The effects of Gilles de la Tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review.
abstract: Gilles de la Tourette syndrome (GTS) and other chronic tic disorders are neurodevelopmental conditions characterized by the presence of tics and associated behavioral problems. Whilst converging evidence indicates that these conditions can affect patients' quality of life (QoL), the extent of this impairment across the lifespan is not well understood. We conducted a systematic literature review of published QoL studies in GTS and other chronic tic disorders to comprehensively assess the effects of these conditions on QoL in different age groups. We found that QoL can be perceived differently by child and adult patients, especially with regard to the reciprocal contributions of tics and behavioral problems to the different domains of QoL. Specifically, QoL profiles in children often reflect the impact of co-morbid attention-deficit and hyperactivity symptoms, which tend to improve with age, whereas adults' perception of QoL seems to be more strongly affected by the presence of depression and anxiety. Management strategies should take into account differences in age-related QoL needs between children and adults with GTS or other chronic tic disorders.
authors.affiliation: Department of Neuropsychiatry, BSMHFT and University of Birmingham Medical School, Birmingham, UK.
authors.forename: Joel
authors.initials: J
authors.lastname: Evans
authors.affiliation: School of Life and Health Sciences, Aston University, Birmingham, UK.
authors.forename: Stefano
authors.initials: S
authors.lastname: Seri
authors.affiliation: Department of Neuropsychiatry, BSMHFT and University of Birmingham Medical School, Birmingham, UK. a.cavanna@ion.ucl.ac.uk.|School of Life and Health Sciences, Aston University, Birmingham, UK. a.cavanna@ion.ucl.ac.uk.|Sobell Department of Motor Neuroscience and Movement Disorders, UCL and Institute of Neurology, London, UK. a.cavanna@ion.ucl.ac.uk.
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Cavanna
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000150:complications / Q000523:psychology; D002648:Child; D003863:Depression / Q000150:complications / Q000523:psychology; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000150:complications / Q000523:psychology; D008297:Male; D011788:Quality of Life / Q000523:psychology*; D013981:Tic Disorders / Q000150:complications / Q000175:diagnosis / Q000523:psychology*; D020323:Tics / Q000150:complications / Q000175:diagnosis / Q000523:psychology*; D005879:Tourette Syndrome / Q000150:complications / Q000175:diagnosis / Q000523:psychology*
keywords: Adults; Behavior; Children; Gilles de la Tourette syndrome; Quality of life; Tics