title: Pericocins A-D, New Bioactive Compounds from Periconia sp.
abstract: One new dihydroisocoumarin, pericocin A (1), one new chromone, pericocin B (2), and two new α-pyrone derivatives, pericocins C-D (3-4), together with two known compounds, 3-(2-oxo-2H-pyran-6-yl)propanoic acid (5) and (E)-3-(2-oxo-2H-pyran-6-yl)acrylic acid (6), were isolated from the culture of the endolichenic fungus Periconia sp.. Their structures were elucidated by spectroscopic methods. All these compounds are derived from the polyketone biosynthetic pathway. Compound 1 was obtained as a mixture of enantiomers. The antimicrobial activity of compounds 1-5 was tested against Escherichia coli, Staphylococcus aureus, Aspergillus niger, and Candida albicans. Compounds 1-5 showed moderate antimicrobial activity against A. niger and weak activity against C. albicans.
authors.forename: Yue-Hua
authors.initials: YH
authors.lastname: Wu
authors.forename: Gao-Keng
authors.initials: GK
authors.lastname: Xiao
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.forename: Chuan-Xi
authors.initials: CX
authors.lastname: Wang
authors.forename: Dan
authors.initials: D
authors.lastname: Hu
authors.forename: Yun-Yang
authors.initials: YY
authors.lastname: Lian
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.forename: Liang-Dong
authors.initials: LD
authors.lastname: Guo
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000737:chemistry*; D006844:Hydrocarbons, Cyclic / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006844:Hydrocarbons, Cyclic