title: Fabrication of an integrated cartilage/bone joint prosthesis and its potential application in joint replacement.
abstract: An integrated cartilage/bone joint prosthesis was designed and fabricated using a two-step molding injection method, in which ethylene-vinyl acetate copolymer (EVA) was used as the upper cartilage layer, and hydroxyapatite/polyamide66 (HA/PA66) composites as the underlying bone layer. Holes punched in the underlying layer improved the interfacial bonding strength between the two layers by means of the mechanical interlocking obviously. Then, the physicochemical properties and in vivo behaviors of the integrated joint prosthesis were investigated. The results showed that the upper layer displayed good bio-tribological properties which were suitable for the articular cartilage replacement, while the underlying layer demonstrated good mechanical performance, excellent biocompatibility and high bioactivity, and could accelerate bone regeneration and the early bio-fixation of the prosthesis. Therefore, the prosthesis prepared here will have a wide prospect to be used in joint replacement.
authors.affiliation: Analytical & Testing Center, Research Center for Nanobiomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Analytical & Testing Center, Research Center for Nanobiomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: School of Materials Science and Engineering, Southwest Petroleum University, Chengdu 610500, China.
authors.forename: Song
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Analytical & Testing Center, Research Center for Nanobiomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Yubao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Electronic address: danqingwang@163.com.
authors.forename: Danqing
authors.initials: D
authors.lastname: Wang
authors.affiliation: Analytical & Testing Center, Research Center for Nanobiomaterials, Sichuan University, Chengdu 610064, China. Electronic address: zhangli9111@126.com.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D019643:Arthroplasty, Replacement; D001861:Bone Regeneration; D002358:Cartilage, Articular; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D007595:Joint Prosthesis; D009757:Nylons / Q000737:chemistry*; D011817:Rabbits
chemical_list: D009757:Nylons; D017886:Durapatite
keywords: EVA; Joint prosthesis; Joint replacement; PA66