title: Germicide wound pad with active, in situ, electrolytically produced hypochlorous acid.
abstract: We describe a new wound dressing technology that can actively generate an inorganic germicide agent, in situ, within the wound pad. The technology provides real time control over the quantitative, spatial and temporal delivery of the germicide. The identity of the germicide is hypochlorous acid (HClO). The HClO is produced in a flexible wound pad, made of a composite of thin (micrometer scale) layers of various materials, with different electrochemical properties that enhance HClO production. Active control over the production of HClO is achieved by control of the pH and of the electric potential across the layers. The effectiveness of the Active HClO Pad (AHClOP) concept is demonstrated in a study on sterilization of E. coli in a deep wound contamination simulating gel. The performance of the AHClOP is compared with that of four commercial wound dressings. Results show that the AHClOP can sterilize throughout the gel, while the commercial dressings cannot.
authors.affiliation: RM2 Technologies LTD., 31 Pegasus Drive, Coto De Caza, CA, 92679, USA.
authors.forename: L
authors.initials: L
authors.lastname: Rubinsky
authors.affiliation: RM2 Technologies LTD., 31 Pegasus Drive, Coto De Caza, CA, 92679, USA.|Exponent, Inc., 149 Commonwealth Dr., Menlo Park, CA, 94025, USA.
authors.forename: B
authors.initials: B
authors.lastname: Patrick
authors.affiliation: RM2 Technologies LTD., 31 Pegasus Drive, Coto De Caza, CA, 92679, USA.
authors.forename: P
authors.initials: P
authors.lastname: Mikus
authors.affiliation: RM2 Technologies LTD., 31 Pegasus Drive, Coto De Caza, CA, 92679, USA. brubinsky@gmail.com.|Department of Mechanical Engineering, University of California Berkeley, Berkeley, CA, 94720, USA. brubinsky@gmail.com.
authors.forename: B
authors.identifier: http://orcid.org/0000-0002-2794-1543
authors.initials: B
authors.lastname: Rubinsky
mesh_terms: D000891:Anti-Infective Agents, Local / Q000737:chemistry* / Q000494:pharmacology; D001458:Bandages / Q000382:microbiology*; D004572:Electrolysis; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D006997:Hypochlorous Acid / Q000737:chemistry* / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000891:Anti-Infective Agents, Local; D006997:Hypochlorous Acid
keywords: Hypochlorous acid; In situ sterilization microdevice; Wound sterilization pad