title: Naproxen, a Nonsteroidal Anti-Inflammatory Drug, Can Affect Daily Hypobaric Hypoxia-Induced Alterations of Monoamine Levels in Different Areas of the Brain in Male Rats.
abstract: Goswami, Ananda Raj, Goutam Dutta, and Tusharkanti Ghosh. Naproxen, a nonsteroidal anti-inflammatory drug can affect daily hypobaric hypoxia-induced alterations of monoamine levels in different areas of the brain in male rats. High Alt Med Biol. 17:133-140, 2016.-The oxidative stress (OS)-induced prostaglandin (PG) release, in hypobaric hypoxic (HHc) condition, may be linked with the changes of brain monoamines. The present study intends to explore the changes of monoamines in hypothalamus (H), cerebral cortex (CC), and cerebellum (CB) along with the motor activity in rats after exposing them to simulated hypobaric condition and the role of PGs on the daily hypobaric hypoxia (DHH)-induced alteration of brain monoamines by administering, an inhibitor of PG synthesis, naproxen. The rats were exposed to a decompression chamber at 18,000 ft for 8 hours per day for 6 days after administration of vehicle or naproxen (18 mg/kg body wt.). The monoamine levels (epinephrine, E; norepinephrine, NE; dopamine, DA; and 5-hydroxytryptamine, 5-HT) in CC, CB, and H were assayed by high-performance liquid chromatography (HPLC) with electrochemical detection, and the locomotor behavior was measured by open field test. The NE and DA levels were decreased in CC, CB, and H of the rat brain in HHc condition. The E and 5-HT levels were decreased in CC, but in H and CB, they remained unaltered in HHc condition. These DHH-induced changes of monoamines in brain areas were prevented after administration of naproxen in HHc condition. The locomotor behavior remained unaltered in HHc condition and after administration of naproxen in HHc condition. The DHH-induced changes of monoamines in the brain in HHc condition are probably linked with PGs that may be induced by OS.
authors.affiliation: Department of Physiology, University College of Science and Technology, University of Calcutta , Kolkata, India .
authors.forename: Ananda Raj
authors.initials: AR
authors.lastname: Goswami
authors.affiliation: Department of Physiology, University College of Science and Technology, University of Calcutta , Kolkata, India .
authors.forename: Goutam
authors.initials: G
authors.lastname: Dutta
authors.affiliation: Department of Physiology, University College of Science and Technology, University of Calcutta , Kolkata, India .
authors.forename: Tusharkanti
authors.initials: T
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001274:Atmospheric Pressure; D015306:Biogenic Monoamines / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects*; D000860:Hypoxia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008297:Male; D009288:Naproxen / Q000494:pharmacology*; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015306:Biogenic Monoamines; D009288:Naproxen
keywords: brain monoamines; dopamine; hypobaric hypoxia; norepinephrine