title: Use of Ulipristal Acetate for the Management of Fibroid-Related Acute Abnormal Uterine Bleeding.
abstract: BACKGROUND
  Episodes of acute abnormal uterine bleeding related to uterine fibroids can cause significant morbidity. Traditional management with high-dose hormonal regimens may not be as effective when used in women with fibroids.
  
  
  METHODS
  A 32-year-old woman with a 12 cm uterine fibroid presented with an episode of acute abnormal uterine bleeding requiring blood transfusion. In lieu of using a hormonal maintenance regimen after the bleeding had stabilized, the patient was treated with ulipristal acetate 5 mg daily for three months. Amenorrhea was induced rapidly and the patient had no further episodes of acute excessive uterine bleeding. She subsequently underwent a laparoscopic myomectomy with a satisfactory outcome.
  
  
  CONCLUSIONS
  Ulipristal acetate has been shown to induce amenorrhea rapidly in women with uterine fibroids, and it can be a useful treatment in the emergency management of fibroid-related acute abnormal uterine bleeding.
authors.affiliation: Department of Obstetrics, Gynecology and Newborn Care, The Ottawa Hospital, University of Ottawa, Ottawa, ON.
authors.forename: Kristina
authors.initials: K
authors.lastname: Arendas
authors.affiliation: Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Leyland
mesh_terms: D000328:Adult; D001803:Blood Transfusion / Q000379:methods; D003270:Contraceptive Agents / Q000008:administration & dosage; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods; D007889:Leiomyoma / Q000150:complications / Q000473:pathology / Q000628:therapy; D009649:Norpregnadienes / Q000008:administration & dosage*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014592:Uterine Hemorrhage / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D063186:Uterine Myomectomy / Q000379:methods*; D014594:Uterine Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy
chemical_list: D003270:Contraceptive Agents; D009649:Norpregnadienes; C555622:ulipristal acetate
keywords: Ulipristal acetate; acute uterine bleeding; fibroids; leiomyoma