title: Protective effects of patchouli alcohol isolated fromPogostemon cablinon lipopolysaccharide-induced acute lung injury in mice.
abstract: Patchouli alcohol (PA) is a tricyclic sesquiterpene isolated from Pogostemon cablin, which exerts anti-inflammatory, anti-influenza and cognitive-enhancing bioactivities. The present study aimed to investigate the protective effects of PA on acute lung injury (ALI) induced by intratracheal instillation of lipopolysaccharide (LPS) in mice. Dexamethasone was used as a positive drug for protection against LPS-induced ALI. The results of the present study demonstrated that pretreatment with PA significantly increased survival rate, attenuated histopathologic damage and lung edema, and decreased the protein content in the bronchoalveolar lavage fluid (BALF) of mice with ALI. Furthermore, PA significantly inhibited the expression levels of proinflammatory cytokines, including tumor necrosis factor (TNF)-α and interleukin (IL)-6 in the BALF, downregulated the levels of myeloperoxidase and malondialdehyde, and upregulated the activity levels of superoxide dismutase and glutathione peroxidase in lung tissue. These results indicated that PA may exert potent protective effects against LPS-induced ALI in mice, the mechanisms of which are possibly associated with the anti-inflammatory and antioxidative activities of PA.
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China; Guangdong Provincal Hospital of Chinese Medicine, Guangzhou, Guangdong 510120, P.R. China.
authors.forename: Zuqing
authors.initials: Z
authors.lastname: Su
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China; Pharmaceutical Department, Guangdong Second Province Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510095, P.R. China.
authors.forename: Jinbin
authors.initials: J
authors.lastname: Liao
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.
authors.forename: Yongzhuo
authors.initials: Y
authors.lastname: Liang
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.
authors.forename: Haiming
authors.initials: H
authors.lastname: Chen
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Chen
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China; Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan, Guangdong 523808, P.R. China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Lai
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.
authors.forename: Xuexuan
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Pharmacy, Shantou Hospital of Traditional Chinese Medicine, Shantou, Guangdong 515031, P.R. China.
authors.forename: Dianwei
authors.initials: D
authors.lastname: Wu
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.
authors.forename: Yucui
authors.initials: Y
authors.lastname: Li
keywords: acute lung injury; anti-inflammatory activity; antioxidative activity; lipopolysaccharide; patchouli alcohol