title: Aerobic oxidative cyclization of benzamides via meta-selective C-H tert-alkylation: rapid entry to 7-alkylated isoquinolinediones.
abstract: A novel copper-catalyzed aerobic oxidative cyclization of benzamides via meta-selective C-H tert-alkylation using AIBN and analogues as radical precursors was described. This strategy provides an elusive and rapid means to 7-tert-alkylated isoquinolinediones, as well as the construction of tertiary alkyl-aryl C(sp(3))-C(sp(2)) bonds with positional selectivity.
authors.affiliation: College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China. stang@jsu.edu.cn.
authors.forename: Shi
authors.initials: S
authors.lastname: Tang
authors.affiliation: College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China. stang@jsu.edu.cn.
authors.forename: You-Lin
authors.initials: YL
authors.lastname: Deng
authors.affiliation: College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China. stang@jsu.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China. stang@jsu.edu.cn.
authors.forename: Wen-Xin
authors.initials: WX
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China. stang@jsu.edu.cn.
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China. stang@jsu.edu.cn.
authors.forename: Zeng-Zeng
authors.initials: ZZ
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China. stang@jsu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Key Laboratory of Cluster Science of Ministry of Education, School of Chemistry, Beijing Institute of Technology, Beijing 100081, China.
authors.forename: Shi-Lu
authors.initials: SL
authors.lastname: Chen
authors.affiliation: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
authors.forename: Rui-Long
authors.initials: RL
authors.lastname: Sheng
mesh_terms: D000478:Alkylation; D001549:Benzamides / Q000737:chemistry*; D003500:Cyclization; D007546:Isoquinolines / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D001549:Benzamides; D007546:Isoquinolines