title: Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies.
abstract: Dysregulated metabolism is an emerging hallmark of cancer, and there is abundant interest in developing therapies to selectively target these aberrant metabolic phenotypes. Sitting at the decision-point between mitochondrial carbohydrate oxidation and aerobic glycolysis (i.e., the 'Warburg effect'), the synthesis and consumption of pyruvate is tightly controlled and is often differentially regulated in cancer cells. This review examines recent efforts toward understanding and targeting mitochondrial pyruvate metabolism, and addresses some of the successes, pitfalls, and significant challenges of metabolic therapy to date.
authors.affiliation: Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112-5650, USA.
authors.forename: Kristofor A
authors.initials: KA
authors.lastname: Olson
authors.affiliation: Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112-5650, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Schell
authors.affiliation: Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112-5650, USA; Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84112-5650, USA. Electronic address: rutter@biochem.utah.edu.
authors.forename: Jared
authors.initials: J
authors.lastname: Rutter
mesh_terms: D006019:Glycolysis; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D010084:Oxidation-Reduction; D019289:Pyruvic Acid / Q000378:metabolism*
chemical_list: D019289:Pyruvic Acid
keywords: cancer; metabolic flexibility; metabolic heterogeneity; metabolism; pyruvate; stem cells