title: The role of leptin in central nervous system diseases.
abstract: Leptin is a peptide hormone produced by adipose tissue and acts in brain centers to control critical physiological functions. Leptin receptors are especially abundant in the hypothalamus and trigger specific neuronal subpopulations, and activate several intracellular signaling events, including the JAK/STAT, MAPK, PI3K, and mTOR pathway. Although most studies focus on its role in energy intake and expenditure, leptin also plays a critical role in many central nervous system diseases.
authors.affiliation: aDepartment of Cardiology, Affiliated Hospital of Binzhou Medical College bInstitute for Metabolic and Neuropsychiatric Disorders, Binzhou Medical University Hospital, Binzhou, China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.forename: Hai-Jing
authors.initials: HJ
authors.lastname: Yan
authors.forename: Yi-Shan
authors.initials: YS
authors.lastname: Guo
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
mesh_terms: D000818:Animals; D002493:Central Nervous System Diseases / Q000378:metabolism*; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D020738:Leptin