title: Steroid-resistant protein-losing gastroenteropathy complicated with Sjögren's syndrome successfully treated with mizoribine.
abstract: A 64-year-old woman with leg edema was diagnosed with protein-losing gastroenteropathy and Sjögren's syndrome. Central venous nutrition led to infection of her catheter, ascites, and deep vein thrombosis. Following successful treatment of these conditions with antibiotics and anticoagulants, she was treated unsuccessfully with prednisolone and steroid pulse therapy. Mizoribine add-on markedly reduced edema and normalized serum albumin. This is the first report of a steroid-resistant protein-losing gastroenteropathy patient with Sjögren's syndrome successfully treated with mizoribine.
authors.affiliation: a Department of Rheumatology.|b General Internal Medicine , and.
authors.forename: Yasumori
authors.initials: Y
authors.lastname: Izumi
authors.affiliation: a Department of Rheumatology.|b General Internal Medicine , and.
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Nakaoka
authors.affiliation: b General Internal Medicine , and.
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Kamata
authors.affiliation: a Department of Rheumatology.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Iwanaga
authors.affiliation: b General Internal Medicine , and.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Imadachi
authors.affiliation: c Pathology , NHO Nagasaki Medical Center , Omura , Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kurohama
authors.affiliation: c Pathology , NHO Nagasaki Medical Center , Omura , Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ito
authors.affiliation: b General Internal Medicine , and.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
mesh_terms: D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D011504:Protein-Losing Enteropathies / Q000150:complications / Q000188:drug therapy*; D012263:Ribonucleosides / Q000008:administration & dosage / Q000627:therapeutic use*; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy*
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine; D011239:Prednisolone
keywords: Mizoribine; Sjögren’s syndrome; Steroid-resistant PLGE