title: Repurposing Drugs to Target the Diabetes Epidemic.
abstract: Despite major investment by pharmaceutical companies in conventional drug discovery pipelines, development of new drugs has failed to keep up with the increasing incidence of many diseases, including type 2 diabetes (T2D). Drug repurposing, where existing drugs are applied to a new indication, is gaining momentum as a successful approach to overcome the bottlenecks commonly encountered with conventional approaches. Repurposing takes advantage of available information on the molecular pharmacology of clinical agents to drastically shorten drug development timelines. This review discusses recent advances in the discovery of new antidiabetic agents using repurposing strategies.
authors.affiliation: Department of Pharmacology, School of Medical Sciences, UNSW Australia, Sydney, Australia.
authors.forename: Nigel
authors.initials: N
authors.lastname: Turner
authors.affiliation: Molecular Pharmacology for Diabetes Group, School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Zeng
authors.affiliation: Department of Pharmacology, School of Medical Sciences, UNSW Australia, Sydney, Australia.
authors.forename: Brenna
authors.initials: B
authors.lastname: Osborne
authors.affiliation: Molecular Pharmacology for Diabetes Group, School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia; La Trobe University, Bundoora, Australia.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Rogers
authors.affiliation: Molecular Pharmacology for Diabetes Group, School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia. Electronic address: jiming.ye@rmit.edu.au.
authors.forename: Ji-Ming
authors.initials: JM
authors.lastname: Ye
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000453:epidemiology; D058492:Drug Repositioning / Q000379:methods*; D058872:Epidemics; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D007004:Hypoglycemic Agents
keywords: alternative strategies; diabetes; drug discovery