title: Plasma microRNA-21 is a potential diagnostic biomarker of acute myocardial infarction.
abstract: OBJECTIVE
  Previous studies have demonstrated that microRNA-21 (miR-21) is involved in the pathogenesis of myocardium infarction and cardiac fibrosis; the present study aimed to investigate its potential role in the diagnosis of acute myocardium infarction (AMI).
  
  
  METHODS
  A cohort of patients with AMI and angina pectoris (AP) were studied, plasma miR-21 level was determined by Realtime-PCR.
  
  
  RESULTS
  We found that the plasma miR-21 level was significantly elevated in patients with AMI compared with those with AP or healthy people. Further studies demonstrated the correlation of miR-21 and several traditional markers such as creatine kinase (CK), creatine kinase-MB (CK-MB) and troponin I (cTnI) in study subjects. Finally, receiver-operator characteristic curve (ROC) analysis showed that miR-21 has similar diagnostic ability compared with CK, CK-MB and cTnI.
  
  
  CONCLUSIONS
  Plasma miR-21 may be a novel biomarker for the diagnosis of AMI. Our study may also provide implications for the development of new biomarkers.
authors.affiliation: Department of Cardiology, Tianjin Chest Hospital, Tianjin, China. yujieliu2012@126.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Liu
authors.forename: T
authors.initials: T
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: S-J
authors.initials: SJ
authors.lastname: Yang
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000787:Angina Pectoris; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D012372:ROC Curve; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; C524940:MIRN21 microRNA, human; D035683:MicroRNAs; D019210:Troponin I; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form