title: Platelet to Lymphocyte Percentage Ratio Is Associated With Brachial-Ankle Pulse Wave Velocity in Hemodialysis.
abstract: Increased arterial stiffness in patients receiving hemodialysis (HD) is highly prevalent and is associated with cardiovascular morbidity and mortality. In HD, inflammation is one of the major causes of increased arterial stiffness. Activation of platelets and decreased lymphocyte percentage (LYMPH%) may exhibit inflammation. The aim of this study is to examine the relationship between platelet to LYMPH% ratio and arterial stiffness in HD patients.A total of 220 patients receiving HD were enrolled in this study. The brachial-ankle pulse wave velocity (baPWV) was measured using an ankle-brachial index form device. Multivariate linear regression analysis was performed to investigate the relations of the platelet to LYMPH% ratio and baPWV. The value of the platelet to LYMPH% ratio was 59.2 ± 33.3 (10 cells/L/%). After multivariate stepwise analysis, diabetes (β: 163.973, P = 0.02), high systolic blood pressure (per 1 mm Hg, β: 9.010, P < 0.001), high platelet to LYMPH% ratio (per 10 cells/L/%, β: 3.334, P < 0.01), and low albumin (per 0.1 mg/dL, β: -55.912, P < 0.001) were independently associated with an increased baPWV. Furthermore, high white blood cells (per 10 cells/L, β: 3.941, P < 0.001), high neutrophil percentage (per 1%, β: 1.144, P < 0.001), and high CRP (per 1 mg/L, β: 9.161, P = 0.03) were independently associated with an increased platelet to LYMPH% ratio.An increased platelet to LYMPH% ratio is associated with an increased baPWV in HD patients. An easy and inexpensive laboratory measure of platelet to LYMPH% ratio may provide an important information regarding arterial stiffness in patients with HD.
authors.affiliation: From the Graduate Institute of Clinical Medicine, College of Medicine (S-CC, M-YL, J-CH, Y-CT); Division of Nephrology (S-CC, J-CH, Y-CT, J-MC, H-CC); Division of Cardiology (H-MS); Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital (M-YL); Department of Internal Medicine (S-CC, M-YL, J-CH, H-MS); Department of Nursing, Kaohsiung Municipal Hsiao-Kang Hospital (H-CM); and Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (S-CC, Y-CT, H-MS, J-MC, H-CC).
authors.forename: Szu-Chia
authors.initials: SC
authors.lastname: Chen
authors.forename: Mei-Yueh
authors.initials: MY
authors.lastname: Lee
authors.forename: Jiun-Chi
authors.initials: JC
authors.lastname: Huang
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Tsai
authors.forename: Hsiu-Chin
authors.initials: HC
authors.lastname: Mai
authors.forename: Ho-Ming
authors.initials: HM
authors.lastname: Su
authors.forename: Jer-Ming
authors.initials: JM
authors.lastname: Chang
authors.forename: Hung-Chun
authors.initials: HC
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D016014:Linear Models; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D063177:Pulse Wave Analysis; D006435:Renal Dialysis; D059289:Vascular Stiffness / Q000502:physiology*