title: Lasting Differential Effects on Plasticity Induced by Prenatal Stress in Dorsal and Ventral Hippocampus.
abstract: Early life adversaries have a profound impact on the developing brain structure and functions that persist long after the original traumatic experience has vanished. One of the extensively studied brain structures in relation to early life stress has been the hippocampus because of its unique association with cognitive processes of the brain. While the entire hippocampus shares the same intrinsic organization, it assumes different functions in its dorsal and ventral sectors (DH and VH, resp.), based on different connectivity with other brain structures. In the present review, we summarize the differences between DH and VH and discuss functional and structural effects of prenatal stress in the two sectors, with the realization that much is yet to be explored in understanding the opposite reactivity of the DH and VH to stressful stimulation.
authors.affiliation: Division of Cellular Neurobiology, Zoological Institute, Technische Universität Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany.
authors.forename: Gayane
authors.initials: G
authors.lastname: Grigoryan
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel.
authors.forename: Menahem
authors.initials: M
authors.lastname: Segal
mesh_terms: D000818:Animals; D005260:Female; D006624:Hippocampus / Q000254:growth & development / Q000503:physiopathology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology* / Q000523:psychology