title: Dual pH-responsive 5-aminolevulinic acid pseudopolyrotaxane prodrug micelles for enhanced photodynamic therapy.
abstract: Novel 5-aminolevulinic acid (ALA) pseudopolyrotaxane prodrug micelles with dual pH-responsive properties were prepared by the host-guest interaction of α-cyclodextrin (α-CD) and poly(ethylene glycol) (PEG). The micelles exhibited pH dependent cellular uptake and pH-sensitive ALA release, enabling enhanced photodynamic therapy.
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis, Functionalization, Department of Polymer Science, Engineering, Zhejiang University, Hangzhou 310027, China. jinqiao@zju.edu.cn jijian@zju.edu.cn.
authors.forename: Hongxin
authors.initials: H
authors.lastname: Tong
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.forename: Huan
authors.initials: H
authors.lastname: Li
authors.forename: Qiao
authors.initials: Q
authors.lastname: Jin
authors.forename: Jian
authors.initials: J
authors.lastname: Ji
mesh_terms: D000622:Aminolevulinic Acid / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D003505:Cyclodextrins / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D015394:Molecular Structure; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D020442:Poloxamer / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry*; D043862:Rotaxanes / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D003505:Cyclodextrins; D008823:Micelles; D017319:Photosensitizing Agents; D011355:Prodrugs; D043862:Rotaxanes; C475674:pseudopolyrotaxane; D020442:Poloxamer; D000622:Aminolevulinic Acid