title: PLK-1: Angel or devil for cell cycle progression.
abstract: PLK-1 is a key player in the eukaryotic cell cycle. Cell cycle progression is precisely controlled by cell cycle regulatory kinases. PLK-1 is a mitotic kinase that actively regulates the G2/M transition, mitosis, mitotic exit, and cytokinesis. During cell cycle progression, PLK-1 controls various events related to the cell cycle maturation, directly and/or indirectly. On the contrary, aberrant expression of PLK-1 is strongly associated with tumorigenesis and its poor prognosis. The misexpression of PLK-1 causes the abnormalities including aneuploidy, mitotic defects, leading to tumorigenesis through inhibiting the p53 and pRB genes. Therefore, we reviewed the role of PLK-1 in the cell cycle progression and in the tumorigenesis either as a cell cycle regulator or on an attractive anti-cancer drug target.
authors.affiliation: Department of Biochemistry, Institute of Cell Differentiation and Aging, Hallym University, College of Medicine, Chucheonsi, Gangwondo 200-704, Republic of Korea. Electronic address: ars198922@gmail.com.
authors.forename: Shiv
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Institute For Skeletal Aging & Orthopedic Surgery, Hallym University, College of Medicine, Chucheonsi, Gangwondo 200-704, Republic of Korea. Electronic address: boneresearch@hallym.ac.kr.
authors.forename: Ashish Ranjan
authors.initials: AR
authors.lastname: Sharma
authors.affiliation: Institute For Skeletal Aging & Orthopedic Surgery, Hallym University, College of Medicine, Chucheonsi, Gangwondo 200-704, Republic of Korea. Electronic address: microbio.garima@gmail.com.
authors.forename: Garima
authors.initials: G
authors.lastname: Sharma
authors.affiliation: Department of Bio-informatics, School of Computer and Information Sciences, Galgotias University, Greater Noida 203201, India. Electronic address: drchiranjib@yahoo.com.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
authors.affiliation: Department of Biochemistry, Institute of Cell Differentiation and Aging, Hallym University, College of Medicine, Chucheonsi, Gangwondo 200-704, Republic of Korea. Electronic address: jbkim@hallym.ac.kr.
authors.forename: Jaebong
authors.initials: J
authors.lastname: Kim
mesh_terms: D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D018385:Centrosome / Q000502:physiology; D048749:Cytokinesis; D004249:DNA Damage; D006801:Humans; D008870:Microtubules / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D000097869:Polo-Like Kinase 1
chemical_list: D018797:Cell Cycle Proteins; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1
keywords: Cell cycle progression; Mitosis; Mitotic kinase; Polo-like kinase-1; Tumorigenesis