title: Identification of Novel Zoonotic Activity of Bartonella spp., France.
abstract: Certain Bartonella species are known to cause afebrile bacteremia in humans and other mammals, including B. quintana, the agent of trench fever, and B. henselae, the agent of cat scratch disease. Reports have indicated that animal-associated Bartonella species may cause paucisymptomatic bacteremia and endocarditis in humans. We identified potentially zoonotic strains from 6 Bartonella species in samples from patients who had chronic, subjective symptoms and who reported tick bites. Three strains were B. henselae and 3 were from other animal-associated Bartonella spp. (B. doshiae, B. schoenbuchensis, and B. tribocorum). Genomic analysis of the isolated strains revealed differences from previously sequenced Bartonella strains. Our investigation identifed 3 novel Bartonella spp. strains with human pathogenic potential and showed that Bartonella spp. may be the cause of undifferentiated chronic illness in humans who have been bitten by ticks.
authors.forename: Muriel
authors.initials: M
authors.lastname: Vayssier-Taussat
authors.forename: Sara
authors.initials: S
authors.lastname: Moutailler
authors.forename: Françoise
authors.initials: F
authors.lastname: Féménia
authors.forename: Philippe
authors.initials: P
authors.lastname: Raymond
authors.forename: Olivier
authors.initials: O
authors.lastname: Croce
authors.forename: Bernard
authors.initials: B
authors.lastname: La Scola
authors.forename: Pierre-Edouard
authors.initials: PE
authors.lastname: Fournier
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
mesh_terms: D000818:Animals; D001473:Bartonella / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D001474:Bartonella Infections / Q000382:microbiology* / Q000635:transmission; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010297:Paris; D064927:Tick Bites; D015047:Zoonoses / Q000382:microbiology*
keywords: Bartonella; France; bacteremia; bacteria; tickborne infections; ticks; vector; vector-borne infections; zoonoses