title: Association between alpha-1 antichymotrypsin gene A/T polymorphism and primary intracerebral hemorrhage: a meta-analysis.
abstract: The present study is to use meta-analysis to explain the association between alpha-1 antichymotrypsin (ACT) gene A/T polymorphism and the risk of primary intracerebral hemorrhage (PICH). Relevant studies before 1 June 2015 were identified by searching PubMed, Cochrane database and Science Citation Index Expanded (SCIE), and the references of retrieved articles. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) were used to assess the strength of the association. Five independent publications, with 774 PICH cases and 940 controls, were included. There was no statistical evidence of association between ACT polymorphism and PICH risk under all genetic models in overall estimates (allele model: OR = 1.01, 95% CI = 0.80-1.28; heterozygote model: OR = 0.93, 95% CI = 0.60-1.45; homozygote model: OR = 1.03, 95% CI = 0.59-1.80; dominant model: OR = 0.97, 95% CI = 0.65-1.46; recessive model: OR = 1.06, 95% CI = 0.72-1.57). No association was found in subgroup analysis based on ethnicity, Hardy-Weinberg equilibrium, location of hematoma and blood pressure. Sensitivity analysis suggested that the combined results were stable and reliable. No significant publication bias was found by Begg's test and Egger's regression test. The results of our meta-analysis indicate that ACT polymorphism is unlikely to contribute to PICH susceptibility.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, P. R. China.
authors.forename: Zusen
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, P. R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ye
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, P. R. China.
authors.forename: Bei
authors.initials: B
authors.lastname: Shao
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, P. R. China.
authors.forename: Jincai
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, P. R. China.
authors.forename: Zhenguo
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, P. R. China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, P. R. China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, P. R. China.
authors.forename: Siyan
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Neurology, Wenzhou Central Hospital & Dingli Clinical Institute of Wenzhou Medical University Wenzhou 325000, P. R. China.
authors.forename: Xiaoya
authors.initials: X
authors.lastname: Huang
keywords: Alpha-1 antichymotrypsin gene; meta-analysis; polymorphism; primary intracerebral hemorrhage