title: Preliminary Favorable Outcome for Medically and Surgically Managed Extensively Drug-Resistant Tuberculosis, France, 2009-2014.
abstract: We report 20 cases of extensively drug-resistant tuberculosis managed in France. Treatment was individualized and included bedaquiline and linezolid for most patients and surgery in 8 patients. At last follow-up (22 months), 19 patients had achieved conversion from positive to negative on culture testing. These promising results of comprehensive management obtained in a small series deserve confirmation.
authors.forename: Benoît
authors.initials: B
authors.lastname: Henry
authors.forename: Matthieu
authors.initials: M
authors.lastname: Revest
authors.forename: Nathalie
authors.initials: N
authors.lastname: Dournon
authors.forename: Loïc
authors.initials: L
authors.lastname: Epelboin
authors.forename: Guillaume
authors.initials: G
authors.lastname: Mellon
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bellaud
authors.forename: Pierre
authors.initials: P
authors.lastname: Mordant
authors.forename: Damien
authors.initials: D
authors.lastname: Le Dû
authors.forename: Nicolas
authors.initials: N
authors.lastname: Véziris
authors.forename: Christine
authors.initials: C
authors.lastname: Bernard
authors.forename: Sébastien
authors.initials: S
authors.lastname: Morel
authors.forename: Stéphane
authors.initials: S
authors.lastname: Jauréguiberry
authors.forename: Christian
authors.initials: C
authors.lastname: Michelet
authors.forename: Françcois
authors.initials: F
authors.lastname: Bricaire
authors.forename: Pierre
authors.initials: P
authors.lastname: Tattevin
authors.forename: Éric
authors.initials: É
authors.lastname: Caumes
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use; D003131:Combined Modality Therapy; D054908:Extensively Drug-Resistant Tuberculosis / Q000453:epidemiology* / Q000266:history / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D049674:History, 21st Century; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000995:Antitubercular Agents
keywords: France; MDR TB; TB; XDR TB; antimicrobial resistance; bacteria; bedaquiline; extensively drug-resistant tuberculosis; multidrug-resistant tuberculosis; outcome; thoracic surgery; tuberculosis; tuberculosis and other mycobacteria