title: CLINICAL CASE OF CONDUCTING PREGNANCY AND CHILDBIRTH AT THE WOMAN WITH CHRONIC VIRAL HEPATITIS B IN THE REPLICATIVE FORM.
abstract: BACKGROUND
  Because of a wide circulation of the hepatitis B (HB) among persons of young age, so-called vertical transmission of a virus from mother to the child is of particular importance. Relevance of this problem of HB increases in connection with a set of ways of infection, failures are more often observed at infection by natural ways: sexual and from mother to a fetus that demands development of effective measures of prevention of transfer from mother to a fetus.
  
  
  OBJECTIVE
  To develop algorithm of maintaining pregnant women with the chronic hepatitis B (HBV) for prevention of perinatal transfer of a HBV infection in the Republic of Sakha (Yakutia) (RS (Y)).
  
  
  METHODS
  Materials of official statistics of Territorial administration of Rospotrebnadzor of RS (Y) are studied, incidence of chronicviral hepatitises B, C and D in RS (Y) from 2003-2013 was analyzed. Clinical, laboratory and tool, serological, molecular and biological methods of research were carried out.
  
  
  RESULTS
  The high incidence of CHV, considerable frequency of delectability of markers of a HB infection at pregnant women, feasibility of a vertical way of a transmission of infection cause interest of doctors of different specialties in this problem. In this scientific publication we analyzed an example of maintaining the pregnant woman, woman in childbirth period with chronic viral hepatitis B, with long "experience" of an illness, with existence of replication of HBV-DNA.
  
  
  CONCLUSIONS
  To decrease the risk of perinatal transfer of a HBV infection it is recommended a quantitative PCR-research among pregnant women with HBsAg which will provide decrease in transmission frequency of HB by carrying out in need of antiviral therapy to the woman and the individualized schedule of vaccinal prevention with introduction of specific immunoglobulin to the newborn.
authors.forename: S
authors.initials: S
authors.lastname: Sleptsova
authors.forename: N
authors.initials: N
authors.lastname: Duglas
authors.forename: L
authors.initials: L
authors.lastname: Shek
mesh_terms: D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006509:Hepatitis B / Q000188:drug therapy* / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control* / Q000706:statistics & numerical data; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology*; D012426:Russia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000998:Antiviral Agents