title: Evidence of Fasciola spp. resistance to albendazole, triclabendazole and bromofenofos in water buffaloes (Bubalus bubalis).
abstract: Fasciolosis caused by Fasciola spp. is considered the most important helminth infection of ruminants in tropical countries. Anthelmintic resistance has become a global concern. This study compared the efficacy of the commonly used anthelmintics, determined the toxicity level and any indication of resistance. Thirty two water buffaloes naturally-infected with Fasciola spp. were used to determine the efficacy of triclabendazole (TBZ), albendazole (ABZ), and bromofenofos (BRO) using Fecal Egg Count Reduction Test (FECRT). To test the toxicity of the drugs given, serum glutamic-pyruvic transaminase (SGPT) was evaluated before and within one week after treatment. One dose administration of ABZ registered an efficacy of 79.17%, 73.33% for TBZ and 70.83% for BRO. Efficacy in two dose- treatment group was 83.33% for both BRO and ABZ, and 90.00% for TBZ. Two dose-treatment was effective for TBZ (90%), ineffective for BRO and ABZ. SGPT levels were not significantly different between pre-treatment and post- treatment across all treatments. Giving one or two doses of anthelmintics, at one month interval, does not increase the efficacy of the three drugs tested. The study also implies that anthelmintic resistance may have developed in the animals.
authors.affiliation: College of Veterinary Science and Medicine, Central Luzon State University, Science City of Muñoz 3120, Nueva Ecija, Philippines.
authors.forename: Virginia M
authors.initials: VM
authors.lastname: Venturina
authors.affiliation: College of Veterinary Science and Medicine, Central Luzon State University, Science City of Muñoz 3120, Nueva Ecija, Philippines.
authors.forename: Ma Antonette F
authors.initials: MA
authors.lastname: Alejandro
authors.affiliation: Animal Health Unit, Philippine Carabao Center National Headquarters and Gene Pool, Science City of Muñoz 3120, Nueva Ecija, Philippines.
authors.forename: Cyril P
authors.initials: CP
authors.lastname: Baltazar
authors.affiliation: Animal Health Unit, Philippine Carabao Center National Headquarters and Gene Pool, Science City of Muñoz 3120, Nueva Ecija, Philippines.
authors.forename: Nancy S
authors.initials: NS
authors.lastname: Abes
authors.affiliation: Animal Health Unit, Philippine Carabao Center National Headquarters and Gene Pool, Science City of Muñoz 3120, Nueva Ecija, Philippines.|Affiliate Faculty, Department of Animal Science, College of Agriculture, Central Luzon State University, Science City of Muñoz 3120, Nueva Ecija, Philippines.
authors.forename: Claro N
authors.initials: CN
authors.lastname: Mingala
mesh_terms: D015766:Albendazole / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D002020:Buffaloes; D004351:Drug Resistance; D005209:Fasciola / Q000187:drug effects*; D005211:Fascioliasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D011075:Polybrominated Biphenyls / Q000494:pharmacology / Q000627:therapeutic use*; D000077682:Triclabendazole
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D011075:Polybrominated Biphenyls; D000077682:Triclabendazole; D015766:Albendazole; C018474:bromophenophos