title: SOD1 gene polymorphisms in sudden sensorineural hearing loss.
abstract: CONCLUSIONS
  The results suggest that SOD1 rs4998557 could be associated with susceptibility to SSNHL in the Japanese population.
  
  
  OBJECTIVE
  To assess the gene association with sudden sensorineural hearing loss (SSNHL).
  
  
  METHODS
  A two-stage case control study was conducted to explore the relationship of the candidate genes to SSNHL. The 192 gene samples from SSNHL patients registered in the intractable inner ear disease gene bank were enrolled. As the candidate genes, 39 SNPs from 31 genes were selected for the first stage study. The second stage study examined whether the SOD1 gene polymorphisms, defined by significant differences between cases and controls in the first stage study, are associated with SSNHL.
  
  
  RESULTS
  Significant differences were observed in four SNPs from three genes, Glutathione-S-transferase pai 1 (GSTP1), proteine kinase C heta (PRKCH), and superoxide dismutase 1 (SOD1), in terms of allele frequency between SSNHL patients and HapMap controls. In the SOD1 gene, a significant difference was observed in the dominant model study of the SNP rs4998557 in the second stage study. Furthermore, as a result of dividing SSNHL patients based on the clinical data, the difference was more apparent in the case of the over 60 dB group and the tinnitus-positive group.
authors.affiliation: a Department of Otorhinolaryngology , Shinshu University School of Medicine , Matsumoto , Nagano , Japan ;
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kitoh
authors.affiliation: a Department of Otorhinolaryngology , Shinshu University School of Medicine , Matsumoto , Nagano , Japan ;
authors.forename: Shin-Ya
authors.initials: SY
authors.lastname: Nishio
authors.affiliation: b Department of Otorhinolaryngology Head and Neck Surgery , Keio University School of Medicine , Tokyo , Japan ;
authors.forename: Kaoru
authors.initials: K
authors.lastname: Ogawa
authors.affiliation: c Department of Otolaryngology , Kitasato University School of Medicine , Sagamihara , Kanagawa , Japan ;
authors.forename: Makito
authors.initials: M
authors.lastname: Okamoto
authors.affiliation: d Department of Otolaryngology , Tokyo Metropolitan Geriatric Hospital , Itabashi-Ku , Tokyo , Japan ;
authors.forename: Ken
authors.initials: K
authors.lastname: Kitamura
authors.affiliation: e Department of Otolaryngology , Ehime University School of Medicine , Shigenobu-Cho , Toon City , Ehime , Japan ;
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Gyo
authors.affiliation: f Department of Otorhinolaryngology , Iwate Medical University , Morioka , Iwate , Japan ;
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sato
authors.affiliation: g Department of Otorhinolaryngology , Nagoya University, Graduate School of Medicine , Showa-Ku , Nagoya , Japan ;
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakashima
authors.affiliation: h Department of Otolaryngology-Head and Neck Surgery , Hokkaido University Graduate School of Medicine , Sapporo , Kita-Ku , Japan ;
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukuda
authors.affiliation: i Department of Otolaryngology-Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmacy , Okayama , Japan ;
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Fukushima
authors.affiliation: j Department of Otolaryngology , Faculty of Medicine, University of Tsukuba , Tsukuba , Japan ;
authors.forename: Akira
authors.initials: A
authors.lastname: Hara
authors.affiliation: k Department of Otolaryngology, Faculty of Medicine , University of Tokyo , Bunkyo-Ku , Tokyo , Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yamasoba
authors.affiliation: a Department of Otorhinolaryngology , Shinshu University School of Medicine , Matsumoto , Nagano , Japan ;
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Usami
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D003639:Hearing Loss, Sudden / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000072105:Superoxide Dismutase-1 / Q000235:genetics*
chemical_list: C000606290:SOD1 protein, human; D000072105:Superoxide Dismutase-1; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi
keywords: Allele frequency; candidate gene; clinical data; dominant model; gene bank