title: Current therapeutic role and medicinal potential of Scutellaria barbata in Traditional Chinese Medicine and Western research.
abstract: BACKGROUND
  Scutellaria barbata is a common herb in Traditional Chinese Medicine (TCM) most often used to treat cancer. S. barbata has been found to exhibit efficacy both in vitro and in vivo on a variety of cancer types. Similarly encouraging results have been shown in patients with metastatic breast cancer from Phase Ia and Ib clinical trials. This study aims to elucidate the current use of S. barbata by TCM practitioners and in current Western research.
  
  
  METHODS
  Semi-structured interviews were conducted with fifteen TCM practitioners in Beijing and Nanjing, China to understand their clinical use of S. barbata. Practitioners were also asked to comment on the future development of TCM using Western research methods and the potential for integration of the two types of medicine in clinical therapy. Statistical analyses were conducted to compare use of S. barbata by disease and in conjunction with other herbs.
  
  
  RESULTS
  Current Western research related to S. barbata is focused on cancer treatment, which corresponds to the most common use of S. barbata by TCM practitioners. Other common uses that practitioners reported included infection and inflammation, for which Beijing practitioners reported use of S. barbata more often than Nanjing practitioners (p<0.05). Hedyotis diffusa was found to be the most commonly cited herb to pair with S. barbata for cancer treatment (p<0.05). When compared to Western clinical trials of BZL101, an S. barbata extract, TCM practitioners reported using smaller doses of S. barbata in shorter durations, in combination with numerous other herbs with the goal to potentiate therapeutic efficacy and mitigate side effects. In addition, TCM practitioners repeatedly emphasized symptom differentiating as the key to achieving maximum therapeutic potential of S. barbata, a factor typically overlooked in Western research.
  
  
  CONCLUSIONS
  Similarities and differences in diagnosis and treatment regimens between TCM practitioners and Western research have the potential to shed light on possible new avenues of research. Additional research may prove beneficial on possible synergistic effects of herbs commonly used with S. barbata, such as Hedyotis diffusa and Lobelia chinensis.
authors.affiliation: Division of Medicinal Chemistry, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
authors.forename: Geyang
authors.initials: G
authors.lastname: Tao
authors.affiliation: Division of Medicinal Chemistry, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA. Electronic address: marcy.balunas@uconn.edu.
authors.forename: Marcy J
authors.initials: MJ
authors.lastname: Balunas
mesh_terms: D035843:Biomedical Research; D006801:Humans; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D031363:Scutellaria; D011795:Surveys and Questionnaires
chemical_list: D010936:Plant Extracts; C524947:Scutellaria barbata extract
keywords: Cancer; Ethnopharmacology; Scutellaria barbata; Traditional Chinese Medicine; Western medicine