title: Synthesis and Biological Properties of Porphyrin-Containing Polymeric Micelles with Different Sizes.
abstract: To understand the size effect of polymeric micelles on their biological properties, such as cellular uptake, biodistribution, tumor accumulation, and so on, we prepared a series of doxorubicin (DOX)-loaded protoporphyrin (PP)-poly(ε-caprolactone) (PCL)-poly(ethylene glycol) (PEG) micelles with different diameters (40, 70, 100, and 130 nm). The incorporation of the protoporphyrin moiety enhanced the stability of the micelles and provided luminescent capability that is useful in the investigation of the cellular uptake of the micelles by fluorescence imaging. The biodistributions of the micelles in mice bearing tumors were evaluated by near-infrared fluorescence imaging and DOX concentration measurements in different tissues. The in vitro and in vivo investigations demonstrated the pronounced dependence of the cellular uptake, biodistribution, and antitumor effectiveness of the micelles on their size.
authors.affiliation: MOE Key Laboratory of High Performance Polymer Materials and Technology, Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, and Jiangsu Key Laboratory for Nanotechnology, Nanjing University , Nanjing, 210093, People's Republic of China.
authors.forename: Jialiang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: MOE Key Laboratory of High Performance Polymer Materials and Technology, Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, and Jiangsu Key Laboratory for Nanotechnology, Nanjing University , Nanjing, 210093, People's Republic of China.
authors.forename: Zhengkui
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: MOE Key Laboratory of High Performance Polymer Materials and Technology, Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, and Jiangsu Key Laboratory for Nanotechnology, Nanjing University , Nanjing, 210093, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.affiliation: MOE Key Laboratory of High Performance Polymer Materials and Technology, Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, and Jiangsu Key Laboratory for Nanotechnology, Nanjing University , Nanjing, 210093, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: MOE Key Laboratory of High Performance Polymer Materials and Technology, Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, and Jiangsu Key Laboratory for Nanotechnology, Nanjing University , Nanjing, 210093, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: MOE Key Laboratory of High Performance Polymer Materials and Technology, Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, and Jiangsu Key Laboratory for Nanotechnology, Nanjing University , Nanjing, 210093, People's Republic of China.
authors.forename: Xiqun
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D065546:Drug Liberation; D000067493:Dynamic Light Scattering; D005027:Ethylene Oxide / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D051379:Mice; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D061848:Optical Imaging; D010316:Particle Size; D011524:Protoporphyrins / Q000737:chemistry*; D014018:Tissue Distribution
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D007783:Lactones; D008823:Micelles; C400421:PLC(20)-b-PEO(44); D011524:Protoporphyrins; D004317:Doxorubicin; C028025:protoporphyrin IX; D005027:Ethylene Oxide
keywords: biodistribution; cellular uptake; polymeric micelles; protoporphyrin; size dependence