title: [Pathological characteristics of coronary artery disease in elderly patients aged 80 years and over].
abstract: OBJECTIVE
  To define the pathological changes of coronary artery and compare the clinical diagnosis and pathological diagnosis differences in elderly patients aged 80 and over.
  
  
  METHODS
  A total of 909 autopsy cases aged 60-100 years in our hospital from April 1st 1969 to October 31th 2013 were analyzed. The prevalence and pathological features of coronary artery disease (CAD) in cases aged 80 years and over were compared with those aged 60-79 years old. The misdiagnosis and missed diagnosis rate were calculated.
  
  
  RESULTS
  The prevalence of CAD by autopsy (63.8% (289/453) vs. 39.9% (182/456), P<0.01), old myocardial infarction (OMI) by autopsy (63.0% (182/289) vs. 51.6% (94/182), P<0.05) and chronic myocardial ischemia by autopsy (22.5% (65/289) vs. 7.1% (13/182), P<0.01) were significantly higher while the prevalence of acute myocardial infarction (AMI) by autopsy was significantly lower (22.1% (64/289) vs. 42.9% (78/182), P<0.01) in aged 80 and over group compared to 60-79 years old group. The misdiagnosis rate of CAD was 65.2% (107/164), the missed diagnosis rate of OMI was 62.1% (113/182) and the missed diagnosis rate of AMI was 37.5% (24/64) in the aged 80 and over group.
  
  
  CONCLUSIONS
  The prevalence of CAD and misdiagnosis and missed diagnosis rate are high in dead inpatients aged 80 years and over. OMI is more common but often missed in this group. Thus, the diagnosis and evaluation of CAD should be enhanced in this patient group.
authors.affiliation: Department of Cardiology, Beijing Hospital, Beijing 100730, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Fang
authors.forename: Ke
authors.initials: K
authors.lastname: Chai
authors.forename: Yao
authors.initials: Y
authors.lastname: Luo
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Dongge
authors.initials: D
authors.lastname: Liu
authors.forename: Shu rong
authors.initials: Sr
authors.lastname: He
authors.forename: Deping
authors.initials: D
authors.lastname: Liu
authors.affiliation: Email: yangjiefu2011@126.com.
authors.forename: Jiefu
authors.initials: J
authors.lastname: Yang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D003324:Coronary Artery Disease / Q000473:pathology*; D003951:Diagnostic Errors; D006801:Humans; D007297:Inpatients; D008875:Middle Aged; D009203:Myocardial Infarction; D017202:Myocardial Ischemia; D015995:Prevalence