title: The factors affecting early death after the initial therapy of acute myeloid leukemia.
abstract: There are some improvements in management of acute myeloid leukemia (AML). However, induction-induced deaths still remain as a major problem. The aim of this study is to assess clinical parameters affecting early death in patients with AML. 199 AML patients, who were treated with intensive, non-intensive or supportive treatment between 2002 and 2014 in Hacettepe Hematology Department, were analyzed retrospectively. In our study early death rate for elderly was found to be lower than previous reports whereas it was similar for those who were under age of 60. Better ECOG performance (ECOG performance score 0 and 1) and non-intensive treatment associated with lower early death rates, however APL-type disease associated with higher early death rates. ECOG performance score at diagnosis was found to be the most related independent factor with higher rate of early death in 15 days after treatment (P<0.001). Therefore we decided to understand the factors which were related with ECOG. WBC count at diagnosis was found to be the only related parameter with ECOG performance score. Leucocyte count at diagnosis appears like to have an indirect effect on early death in AML patients. It maybe suggested that in recent years there is an improvement in early death rates of elderly AML patients. The currently reported findings require prospective validation and would encourage the incorporation of other next generation genomics for the prediction of early death and overall risk status of AML.
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Umit Yavuz
authors.initials: UY
authors.lastname: Malkan
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Gursel
authors.initials: G
authors.lastname: Gunes
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Eylem
authors.initials: E
authors.lastname: Eliacik
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Ibrahim Celalettin
authors.initials: IC
authors.lastname: Haznedaroglu
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Sezgin
authors.initials: S
authors.lastname: Etgul
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Aslan
authors.affiliation: Department of Hematology, Diskapi Research and Training Hospital TR-0100 Ankara, Turkey.
authors.forename: Okan
authors.initials: O
authors.lastname: Yayar
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Aydin
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Haluk
authors.initials: H
authors.lastname: Demiroglu
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Osman Ilhami
authors.initials: OI
authors.lastname: Ozcebe
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Nilgun
authors.initials: N
authors.lastname: Sayinalp
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Goker
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Aksu
authors.affiliation: Department of Hematology, Hacettepe University, School of Medicine TR-0100 Ankara, Turkey.
authors.forename: Yahya
authors.initials: Y
authors.lastname: Buyukasik
keywords: Acute myeloid leukemia; early death