title: Low Response of Renin-Angiotensin System to Sodium Intake Intervention in Chinese Hypertensive Patients.
abstract: The interactions of sodium balance and response of renin-angiotensin-aldosterone system are important for maintaining the hemodynamic stability in physiological conditions. However, the influence of short-term sodium intake intervention in the response of renin-angiotensin system (RAS) on hypertensive patients is still unclear. Thus, we conducted a clinical trial to investigate the effects of short-term sodium intake intervention on the response of RAS in hypertensive patients.One hundred twenty-five primary Chinese hypertensive patients were divided into high, moderate, and low sodium groups by 24-hour urinary sodium excretion (UNa). All the patients received a 10-day dietary sodium intake intervention with standardized sodium (173.91mmol/day) and potassium (61.53mmol/day). Blood pressure, urinary sodium, urinary potassium, plasma sodium, potassium, creatinine, the levels of plasma renin activity, plasma angiotensin II concentrations (AT-II), and plasma aldosterone concentrations were detected before and after the intervention.Before the intervention, no differences were found in blood pressure and RAS among 3 groups. After standardized dietary sodium intake intervention, both UNa excretion and systolic pressure decreased in high-sodium group, while they increased in moderate and low-sodium groups. Intriguingly, there were no changes in the levels of plasma renin activity, AT-II, and plasma aldosterone concentrations among 3 groups during the intervention.The present study demonstrated that the influenced sodium excretion and blood pressure by short-term sodium intake intervention were independent of RAS quick response in Chinese hypertensive patients.
authors.affiliation: From the Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology (WF, WY, ASAB, JW, JC, HH); Department of Cardiology (WF, WY, JW, HH), Sun Yat-sen Memorial Hospital of Sun Yat-sen University; Department of Medical Oncology (QC), Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou; Department of Cardiology (YL), The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning; and Department of Radiation Oncology (JC), Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Weijing
authors.initials: W
authors.lastname: Feng
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Cai
authors.forename: Woliang
authors.initials: W
authors.lastname: Yuan
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Adham Sameer A
authors.initials: ASA
authors.lastname: Bardeesi
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001795:Blood Pressure Determination; D002681:China; D004039:Diet, Sodium-Restricted; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis / Q000178:diet therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin