title: [Effect of human papilloma virus infection status on the prognosis of localized stage head and neck squamous cell carcinomas in different ethnic groups of Xinjiang].
abstract: OBJECTIVE
  To discuss the effect of limited head and neck squamous cell carcinomas human papillomavirus(HPV) infection status on the prognosis in different nationalities of Xinjiang.
  
  
  METHODS
  The clinical data of 149 cases of head and neck squamous cell carcinoma from Uighur, Han and Kazak was analyzed. The HPV16/18 infection and viral load was examined.The prognosis was analyzed by cox multiIvar-Iate model. The effect of HPV infection status on prognosis was evaluated.
  
  
  RESULTS
  In this study, Oropharyngeal HPV infection rate was 35.0%, followed by hypopharynx 30.0%, oropharyx was 16.0%. The overall survival rate of 3 years and 5 years was 66.4%, and 39.2% respectively. The clinical stage,N stage and HPV were influencing factors for the prognosis of patients with head and neck squamous cell carcinoma (P< 0.05). N stage and HPV were independent prognostic factors for the prognosis of patients with head and neck squamous cell carcinoma (P< 0.05).
  
  
  CONCLUSIONS
  There is a high rate of HPV infection in oropharynx in head and neck cancer. HPV positive is a protective factor for the prognosis of head and neck cancer, and the risk of death in patients with HPV was 3/5 lower than that of HPV negative patients. HPV viral load may be positively related to the total survival rate. N stage is a risk factor for the prognosis of head and neck cancer. Different nationalities have little influence on prognosis.
authors.affiliation: Department of Oncology , The First Affiliated Hospital, Xinjiang Medical University, Urumqi Xinjiang 830011, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Songan
authors.initials: S
authors.lastname: Zhang
authors.forename: Tu-er-xun
authors.initials: TE
authors.lastname: A Er-Zi-Gi
authors.affiliation: Email: xydyfyzhr@163.com.
authors.forename: Huarong
authors.initials: H
authors.lastname: Zhao
authors.forename: Ni-ya-zi
authors.initials: NY
authors.lastname: Hu Er-Xidan
authors.forename: Yongxing
authors.initials: Y
authors.lastname: Bao
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000208:ethnology / Q000401:mortality / Q000473:pathology / Q000821:virology*; D002681:China; D005006:Ethnicity; D006258:Head and Neck Neoplasms / Q000208:ethnology / Q000401:mortality / Q000473:pathology / Q000821:virology*; D052162:Human papillomavirus 16; D052161:Human papillomavirus 18; D006801:Humans; D009367:Neoplasm Staging; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000401:mortality / Q000821:virology; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate; D013997:Time Factors; D019562:Viral Load