title: Copper-Catalyzed Insertion into Heteroatom-Hydrogen Bonds with Trifluorodiazoalkanes.
abstract: Copper-catalyzed Si-H, B-H, P-H, S-H, and N-H insertion reactions of 2,2,2-trifluoro-1-diazoethane and 1-aryl 2,2,2-trifluorodiazoethanes generated a large number of new fluorine-containing chemical entities for medicinal chemists. With selected Si-H and B-H insertion reactions, we demonstrate successful extension to asymmetric catalysis.
authors.affiliation: University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Hyde
authors.affiliation: University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
authors.forename: Janis
authors.initials: J
authors.lastname: Veliks
authors.affiliation: University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.|Institut Charles Gerhardt Montpellier, UMR-CNRS 5253, AM2N, ENSCM, 8 rue de l'Ecole Normale, 34296, Montpellier Cedex 5, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Liégault
authors.affiliation: University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
authors.forename: David
authors.initials: D
authors.lastname: Grassi
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR-CNRS 5253, AM2N, ENSCM, 8 rue de l'Ecole Normale, 34296, Montpellier Cedex 5, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Taillefer
authors.affiliation: University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK. veronique.gouverneur@chem.ox.ac.uk.
authors.forename: Véronique
authors.initials: V
authors.lastname: Gouverneur
keywords: asymmetric catalysis; carbenes; copper catalysis; diazo compounds; heteroatom-hydrogen insertion