title: Fluorescent Bioactive Corrole Grafted-Chitosan Films.
abstract: Transparent corrole grafted-chitosan films were prepared by chemical modification of chitosan with a corrole macrocycle, namely, 5,10,15-tris(pentafluorophenyl)corrole (TPFC), followed by solvent casting. The obtained films were characterized in terms of absorption spectra (UV-vis), FLIM (fluorescence lifetime imaging microscopy), structure (FTIR, XPS), thermal stability (TGA), thermomechanical properties (DMA), and antibacterial activity. The results showed that the chemical grafting of chitosan with corrole units did not affect its film-forming ability and that the grafting yield increased with the reaction time. The obtained transparent films presented fluorescence which increases with the amount of grafted corrole units. Additionally, all films showed bacteriostatic effect against S. aureus, as well as good thermomechanical properties and thermal stability. Considering these features, promising applications may be envisaged for these corrole-chitosan films, such as biosensors, bioimaging agents, and bioactive optical devices.
authors.forename: Joana F B
authors.initials: JF
authors.lastname: Barata
authors.forename: Ricardo J B
authors.initials: RJ
authors.lastname: Pinto
authors.affiliation: Centro Química Estrutural, Complexo I, Instituto Superior Técnico , 1049-001 Lisboa, Portugal.
authors.forename: Vanda I R C
authors.initials: VI
authors.lastname: Vaz Serra
authors.forename: Armando J D
authors.initials: AJ
authors.lastname: Silvestre
authors.forename: Tito
authors.initials: T
authors.lastname: Trindade
authors.forename: Maria Graça P M S
authors.initials: MG
authors.lastname: Neves
authors.forename: José A S
authors.initials: JA
authors.lastname: Cavaleiro
authors.affiliation: INNOVHUB - Divisione Carta, Piazza Leonardo Da Vinci, 16, 20133 Milan, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Daina
authors.affiliation: INNOVHUB - Divisione Carta, Piazza Leonardo Da Vinci, 16, 20133 Milan, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Sadocco
authors.forename: Carmen S R
authors.initials: CS
authors.lastname: Freire
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D048271:Chitosan / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D011166:Porphyrins; D048271:Chitosan