title: Factors Associated with Loss to Follow-up during Treatment for Multidrug-Resistant Tuberculosis, the Philippines, 2012-2014.
abstract: To identify factors associated with loss to follow-up during treatment for multidrug-resistant (MDR) tuberculosis (TB) in the Philippines, we conducted a case-control study of adult patients who began receiving treatment for rifampin-resistant TB during July 1-December 31, 2012. Among 91 case-patients (those lost to follow-up) and 182 control-patients (those who adhered to treatment), independent factors associated with loss to follow-up included patients' higher self-rating of the severity of vomiting as an adverse drug reaction and alcohol abuse. Protective factors included receiving any type of assistance from the TB program, better TB knowledge, and higher levels of trust in and support from physicians and nurses. These results provide insights for designing interventions aimed at reducing patient loss to follow-up during treatment for MDR TB.
authors.forename: Thelma E
authors.initials: TE
authors.lastname: Tupasi
authors.forename: Anna Marie Celina G
authors.initials: AM
authors.lastname: Garfin
authors.forename: Ekaterina V
authors.initials: EV
authors.lastname: Kurbatova
authors.forename: Joan M
authors.initials: JM
authors.lastname: Mangan
authors.forename: Ruth
authors.initials: R
authors.lastname: Orillaza-Chi
authors.forename: Leilani C
authors.initials: LC
authors.lastname: Naval
authors.forename: Glenn I
authors.initials: GI
authors.lastname: Balane
authors.forename: Ramon
authors.initials: R
authors.lastname: Basilio
authors.forename: Alexander
authors.initials: A
authors.lastname: Golubkov
authors.forename: Evelyn S
authors.initials: ES
authors.lastname: Joson
authors.forename: Woo-Jin
authors.initials: WJ
authors.lastname: Lew
authors.forename: Vivian
authors.initials: V
authors.lastname: Lofranco
authors.forename: Mariquita
authors.initials: M
authors.lastname: Mantala
authors.forename: Stuart
authors.initials: S
authors.lastname: Pancho
authors.forename: Jesus N
authors.initials: JN
authors.lastname: Sarol
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D049674:History, 21st Century; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010679:Philippines / Q000453:epidemiology; D012307:Risk Factors; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology* / Q000266:history; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents
keywords: MDR TB; TB; follow-up; multidrug-resistant tuberculosis; patient compliance; risk factors; side effects; the Philippines; treatment; tuberculosis and other mycobacteria