title: Nanoscale Polymersomes as Anti-Cancer Drug Carriers Applied for Pharmaceutical Delivery.
abstract: Polymersomes are self-assembled nano-vesicles composed of amphiphilic block copolymers. These building blocks can be selected from a large number of hydrophilic and hydrophobic polymers in order to achieve required properties of the final system, such as biodegradability, sustainable and multiple stimuli-response drug release, long blood circulation, and low toxicity. Moreover, the surface of polymersomes can be functionalized to induce targeting character. Polymersomes are able to encapsulate a broad range of hydrophilic or/and hydrophobic molecules either in the aqueous core or membrane bilayer, respectively. In addition, colloidal stability and low membrane fluidity make polymersomes attractive nano-sized drug carriers. The review describes polymersomes compositions, their applications in pharmaceutical delivery, and preparation methods.
authors.forename: Ruslan G
authors.initials: RG
authors.lastname: Tuguntaev
authors.forename: Chukwunweike Ikechukwu
authors.initials: CI
authors.lastname: Okeke
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Chan
authors.initials: C
authors.lastname: Li
authors.forename: Paul C
authors.initials: PC
authors.lastname: Wang
authors.affiliation: Laboratory of Controllable Nanopharmaceuticals, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China. liangxj@nanoctr.cn.
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011108:Polymers