title: New Alkaloids from Green Vegetable Soybeans and Their Inhibitory Activities on the Proliferation of Concanavalin A-Activated Lymphocytes.
abstract: A comprehensive phytochemical study of the chemical constituents of green vegetable soybeans resulted in the isolation of two new alkaloids, soyalkaloid A, 1, and isoginsenine, 2, together with four known ones, ginsenine, 3, (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, 4, (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, 5, and indole-3-carboxylic acid, 6. The structures of compounds 1-6 were elucidated on the basis of spectroscopic and chemical analyses. All of the alkaloids were isolated from soybeans for the first time, and compound 1 was a new indole-type alkaloid with a novel carbocyclic skeleton. Their inhibitory activities on the proliferation of concanalin A-activated lymphocytes were assessed by CCK8 assay.
authors.forename: Taoyun
authors.initials: T
authors.lastname: Wang
authors.affiliation: National Center for Natural Products Research, and Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi , University, Mississippi 38677, United States.
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhao
authors.forename: Xiaoran
authors.initials: X
authors.lastname: Li
authors.forename: Qiongming
authors.initials: Q
authors.lastname: Xu
authors.forename: Yanli
authors.initials: Y
authors.lastname: Liu
authors.affiliation: National Center for Natural Products Research, and Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi , University, Mississippi 38677, United States.
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
authors.forename: Shilin
authors.initials: S
authors.lastname: Yang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000378:metabolism*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013025:Glycine max / Q000737:chemistry*; D014675:Vegetables / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D010936:Plant Extracts; D003208:Concanavalin A
keywords: Glycine max; alkaloids; immunosuppression; soybean; structure identification