title: Serum Type IV Collagen Concentration Correlates with Indocyanine Green Retention Rate and is an Indicator Of Hepatotoxicity In Patients Receiving FOLFOX for Colorectal Cancer.
abstract: BACKGROUND
  Assessment of oxaliplatin-associated hepatotoxicity in patients receiving oxaliplatin, fluorouracil and leucovorin chemotherapy (FOLFOX) for colorectal cancer remains controversial. The aims of this study were to clarify which variables are indicators of such hepatotoxicity.
  
  
  METHODS
  Twenty-seven patients who were to receive FOLFOX for colorectal cancer were included in this study. A range of liver function tests, including serum hyaluronic acid (HA) and type IV collagen concentrations, indocyanine green (ICG) retention rate at 15 min (ICGR15) and splenic volume were assessed before commencement of chemotherapy and after four cycles of FOLFOX.
  
  
  RESULTS
  No significant changes were found in conventional liver function tests or splenic volume. Significant changes pre- and post-FOLFOX were found in type IV collagen concentrations and ICGR15. Correlation analyses showed that the following two factors were associated with significant changes in ICGR15 after four cycles of FOLFOX: platelet count (p = 0.028, correlation coefficient 0.423), and type IV collagen concentration (p < 0.001, correlation coefficient 0.830). The regression line between type IV collagen concentration and ICGR15 was Y = 2.70 + 0.84 x X.
  
  
  CONCLUSIONS
  Serum type IV collagen concentration is an indicator of oxaliplatin-associated hepatotoxicity and correlates with significant changes in ICGR15 in patients receiving FOLFOX.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hosokawa
authors.forename: Masato
authors.initials: M
authors.lastname: Watanabe
authors.forename: Hirochika
authors.initials: H
authors.lastname: Makino
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mushiake
authors.forename: Kenji
authors.initials: K
authors.lastname: Katsumata
authors.forename: Kaname
authors.initials: K
authors.lastname: Maruno
authors.forename: Shozo
authors.initials: S
authors.lastname: Fujino
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Sugiyama
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D024141:Collagen Type IV / Q000097:blood*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005456:Fluorescent Dyes; D005472:Fluorouracil / Q000009:adverse effects; D006801:Humans; D007208:Indocyanine Green; D002955:Leucovorin / Q000009:adverse effects; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D024141:Collagen Type IV; D005456:Fluorescent Dyes; D009944:Organoplatinum Compounds; D007208:Indocyanine Green; D002955:Leucovorin; D005472:Fluorouracil