title: Concentrations of adipokines in children before and after hematopoietic stem cell transplantation.
abstract: Adipokines have multiple effects, including regulation of glucose metabolism, cell proliferation, inflammation, and angiogenesis. The aim of the study was to determine plasma concentrations of adiponectin, apelin, leptin, and resistin as well as soluble leptin receptor in pediatric hematopoietic stem cell transplantation (HSCT). The expression of genes encoding the studied peptides was measured using microarray technique. Plasma concentrations of tested peptides were measured before and after oral glucose tolerance test in children treated with HSCT (n = 38) and in healthy controls (n = 26). The peptides were measured before HSCT (pre-HSCT group; n = 38) and after a median of 6 months after HSCT (post-HSCT group; n = 27 of 38 children treated with HSCT). In addition, measurements of fasting plasma glucose, insulin, lipids, and high-sensitivity C-reactive protein (hsCRP) were performed. In both HSCT groups, atherogenic lipid profile, low-grade systemic inflammation was observed. Leptin, adiponectin, and resistin also appear to be good markers of disease burden and low-grade systemic inflammation. Adipokines may be good markers of disease burden and may influence metabolic complications of HSCT. Future studies on larger groups of patients will explain if changes of the concentrations of leptin, adiponectin, and apelin observed in our study and confirmed by expression levels influence engraftment and reconstitution of cell lines.
authors.affiliation: a Department of Clinical Immunology, Chair of Clinical Immunology and Transplantation , Institute of Pediatrics, Jagiellonian University Medical College , Krakow , Poland.
authors.forename: Szymon
authors.initials: S
authors.lastname: Skoczen
authors.affiliation: b Department of Clinical Biochemistry , Institute of Pediatrics, Jagiellonian University Medical College , Krakow , Poland.
authors.forename: Przemyslaw J
authors.initials: PJ
authors.lastname: Tomasik
authors.affiliation: c Department of Statistics , Cracow University of Economics , Krakow , Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Fijorek
authors.affiliation: d Department of Oncology and Hematology , Institute of Pediatrics, Jagiellonian University Medical College , Krakow , Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Strojny
authors.affiliation: d Department of Oncology and Hematology , Institute of Pediatrics, Jagiellonian University Medical College , Krakow , Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Wieczorek
authors.affiliation: d Department of Oncology and Hematology , Institute of Pediatrics, Jagiellonian University Medical College , Krakow , Poland.
authors.forename: Walentyna
authors.initials: W
authors.lastname: Balwierz
authors.affiliation: b Department of Clinical Biochemistry , Institute of Pediatrics, Jagiellonian University Medical College , Krakow , Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Sztefko
authors.affiliation: a Department of Clinical Immunology, Chair of Clinical Immunology and Transplantation , Institute of Pediatrics, Jagiellonian University Medical College , Krakow , Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Siedlar
mesh_terms: D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D000328:Adult; D064591:Allografts; D014408:Biomarkers, Tumor / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D019337:Hematologic Neoplasms / Q000097:blood* / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D011184:Postoperative Period; D057234:Preoperative Period
chemical_list: D054392:Adipokines; D014408:Biomarkers, Tumor
keywords: Adipokines; children; stem cell transplantation