title: Antibacterial electrospun chitosan-polyethylene oxide nanocomposite mats containing bioactive silver nanoparticles.
abstract: The antimicrobial chitosan-polyethylene oxide (CS-PEO) nanofibrous mats were developed by electrospinning technique for wound dressing applications. Indeed, a green route was introduced for fabrication of antibacterial mats loaded with 0.25% and 0.50% (w/w) of bioactive silver nanoparticles (Ag NPs, ∼70nm diameter) reduced by Falcaria vulgaris herbal extract. The mats were characterized by FE-SEM, EDAX, elemental mapping, FT-IR, contact angle, TGA/DSC as well as tensile strength analysis. All of the nanofibers had an average ∼200nm diameter. Interestingly, both of the CS-PEO mats containing 0.25% and 0.50% bioactive F. vulgaris-Ag NPs revealed 100% bactericidal activities against both Staphylococcus aureus and Escherichia coli bacteria. The silver release from nanofiber mats was sharply increased within first eight hours for both CS-PEO mats including 0.25% and 0.50% F. vulgaris-Ag NPs but after that the Ag nanoparticles were released very slowly (almost constant). The improved hydrophilicity, higher tensile strength and much greater silver release for CS-PEO-0.50% F. vulgaris-Ag NPs relative to those of the CS-PEO 0.25% F. vulgaris-Ag NPs suggested that the former was superior for biomedical applications.
authors.affiliation: Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), PO Box 15875-4413, Tehran, Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Kohsari
authors.affiliation: Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), PO Box 15875-4413, Tehran, Iran. Electronic address: shariati@aut.ac.ir.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Shariatinia
authors.affiliation: Faculty of Material and Manufacturing Technologies, Malek Ashtar University of Technology, PO Box 16765-3454, Tehran, Iran.
authors.forename: Seied Mahdi
authors.initials: SM
authors.lastname: Pourmortazavi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry*; D004560:Electricity; D004926:Escherichia coli / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D036103:Nanotechnology; D011092:Polyethylene Glycols / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013718:Tensile Strength; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D014867:Water; D012834:Silver; D011092:Polyethylene Glycols; D048271:Chitosan
keywords: Antimicrobial activity; Chitosan–polyethylene oxide nanofibrous mats; Electrospinning; Falcaria vulgaris herbal extract; Silver nanoparticles