title: Analgesic use and the risk of primary adult brain tumor.
abstract: Glioma and meningioma are uncommon tumors of the brain with few known risk factors. Regular use of aspirin has been linked to a lower risk of gastrointestinal and other cancers, though evidence for an association with brain tumors is mixed. We examined the association of aspirin and other analgesics with the risk of glioma and meningioma in a large US case-control study. Cases were persons recently diagnosed with glioma or meningioma and treated at medical centers in the southeastern US. Controls were persons sampled from the same communities as the cases combined with friends and other associates of the cases. Information on past use of analgesics (aspirin, other anti-inflammatory agents, and acetaminophen) was collected in structured interviews. Logistic regression was used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) for analgesic use adjusted for potential confounders. All associations were considered according to indication for use. A total of 1123 glioma cases, 310 meningioma cases and 1296 controls were included in the analysis. For indications other than headache, glioma cases were less likely than controls to report regular use of aspirin (OR 0.69; CI 0.56, 0.87), in a dose-dependent manner (P trend < 0.001). No significant associations were observed with other analgesics for glioma, or any class of pain reliever for meningioma. Results suggest that regular aspirin use may reduce incidence of glioma.
authors.affiliation: Division of Population Sciences, Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC-CANCONT, Tampa, FL, 33612-9416, USA. Kathleen.Egan@moffitt.org.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Egan
authors.affiliation: Neuro-Oncology Program, University of Alabama at Birmingham, FOT 1020, 510 20th St. South, Birmingham, AL, 35294, USA.
authors.forename: Louis B
authors.initials: LB
authors.lastname: Nabors
authors.affiliation: Division of Population Sciences, Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC-CANCONT, Tampa, FL, 33612-9416, USA.
authors.forename: Zachary J
authors.initials: ZJ
authors.lastname: Thompson
authors.affiliation: Division of Population Sciences, Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC-CANCONT, Tampa, FL, 33612-9416, USA.
authors.forename: Carrie M
authors.initials: CM
authors.lastname: Rozmeski
authors.affiliation: Division of Population Sciences, Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC-CANCONT, Tampa, FL, 33612-9416, USA.
authors.forename: Gabriella A
authors.initials: GA
authors.lastname: Anic
authors.affiliation: Department of Neurosurgery, Emory University School of Medicine, 1365-B Clifton Rd., NE, Ste. 2200, Atlanta, GA, 30322, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Olson
authors.affiliation: Department of Hematology-Oncology, Norton Cancer Institute, 315 E. Broadway, Louisville, KY, 40202, USA.
authors.forename: Renato V
authors.initials: RV
authors.lastname: LaRocca
authors.affiliation: Neuro-Oncology Program, Lynn Cancer Institute and the Boca Raton Regional Hospital, 701 NW 13th Street, Boca Raton, FL, 33486, USA.
authors.forename: Sajeel A
authors.initials: SA
authors.lastname: Chowdhary
authors.affiliation: Department of Neuro-Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Forsyth
authors.affiliation: Department of Neurological Surgery, Vanderbilt University Medical Center, 691 Preston Building, Nashville, TN, 37232, USA.
authors.forename: Reid C
authors.initials: RC
authors.lastname: Thompson
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D016022:Case-Control Studies; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D005260:Female; D005910:Glioma / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008579:Meningioma / Q000453:epidemiology / Q000517:prevention & control; D008875:Middle Aged; D012306:Risk; D055815:Young Adult
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D000082:Acetaminophen; D001241:Aspirin
keywords: Aspirin; Case–control study; Epidemiology; Glioblastoma; Glioma; Nonsteroidal anti-inflammatory agents; Prevention; Risk