title: Chromosomal analyses of 1510 couples who have experienced recurrent spontaneous abortions.
abstract: In this retrospective study, karyotype results of 1510 couples with a history of recurrent spontaneous abortion were evaluated. The study was conducted at Balcalı Hospital in Adana region of Turkey. For all cases, peripheral blood lymphocytes were cultured for chromosome study using the standard method. Chromosome aberrations were detected in 62 couples (4.1% of all couples). At an individual level, chromosome aberrations were found in a total of 65 cases (41 females and 24 male cases), with structural chromosomal aberrations in 58 cases including balanced translocations in 30 cases, Robertsonian translocations in 12 cases, deletions in seven cases, inversions in nine cases and numerical chromosome aberrations in seven cases. The results of the study indicated that structural aberrations, particularly translocations, were the most common type of aberration observed among couples who had experienced recurrent spontaneous abortions and that these couples might benefit from cytogenetic analyses.
authors.affiliation: Medical Biology and Genetics Department, Çukurova University, 01330, Adana, Turkey.
authors.forename: Erdal
authors.initials: E
authors.lastname: Tunç
authors.affiliation: Medical Biology and Genetics Department, Çukurova University, 01330, Adana, Turkey.
authors.forename: Nilgün
authors.initials: N
authors.lastname: Tanrıverdi
authors.affiliation: Medical Biology and Genetics Department, Çukurova University, 01330, Adana, Turkey. Electronic address: osdemir@cu.edu.tr.
authors.forename: Osman
authors.initials: O
authors.lastname: Demirhan
authors.affiliation: Medical Biology and Genetics Department, Çukurova University, 01330, Adana, Turkey.
authors.forename: Dilara
authors.initials: D
authors.lastname: Süleymanova
authors.affiliation: Medical Biology and Genetics Department, Çukurova University, 01330, Adana, Turkey.
authors.forename: Nesrin
authors.initials: N
authors.lastname: Çetinel
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D007446:Chromosome Inversion; D020732:Cytogenetic Analysis; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D059785:Karyotype; D008297:Male; D012189:Retrospective Studies; D014178:Translocation, Genetic
keywords: aberrations; chromosome; lymphocytes; recurrent miscarriages; translocations