title: LincRNA-ROR promotes invasion, metastasis and tumor growth in pancreatic cancer through activating ZEB1 pathway.
abstract: Pancreatic cancer (PC) remains one of the most lethal malignant tumors; early distant metastasis commonly results in poor prognosis. Recent studies confirmed the pivotal role of the long non-coding RNAs (lncRNAs) in tumorigenesis and metastasis of malignant tumors, including PC. However, little is known about the role of LincRNA-ROR (linc-ROR) in PC. In the present study, we found that linc-ROR was upregulated in PC tissues. Overexpression of linc-ROR promoted cells proliferation, migration, invasion and metastasis both in vitro and in a mouse model. Contrarily, knockdown of linc-ROR attenuated proliferation, invasion and distant metastasis. Mechanistically, we confirmed that linc-ROR up-regulates ZEB1 and then induces epithelial-mesenchymal transition (EMT), which promotes the aggressive biological behaviors of PC. Together, these results indicate that linc-ROR acts as an important regulator of ZEB1, can promote invasion and metastasis in PC, and may represent a novel therapeutic target.
authors.affiliation: Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong Province 250012, China.
authors.forename: Han-Xiang
authors.initials: HX
authors.lastname: Zhan
authors.affiliation: International Biotechnology R&D Center, Shandong University School of Ocean, Weihai, Shandong Province 264209, China; School of Pharmaceutical Sciences, Shandong University, Shandong Province 250012, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: International Biotechnology R&D Center, Shandong University School of Ocean, Weihai, Shandong Province 264209, China; School of Pharmaceutical Sciences, Shandong University, Shandong Province 250012, China.
authors.forename: Ce
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong Province 250012, China.
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Xu
authors.affiliation: Department of Hepatobiliary Surgery, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong Province 250012, China.
authors.forename: Jian-Kang
authors.initials: JK
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong Province 250012, China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Han
authors.affiliation: Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong Province 250012, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: International Biotechnology R&D Center, Shandong University School of Ocean, Weihai, Shandong Province 264209, China. Electronic address: wangyunshan135@126.com.
authors.forename: Yun-Shan
authors.initials: YS
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong Province 250012, China. Electronic address: husanyuan1962@hotmail.com.
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Hu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D055785:Gene Knockdown Techniques; D064593:Heterografts; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation; D000071799:Zinc Finger E-box-Binding Homeobox 1
chemical_list: D018398:Homeodomain Proteins; C000588825:Linc-RNA-RoR, human; D062085:RNA, Long Noncoding; D014157:Transcription Factors; C486307:ZEB1 protein, human; D000071799:Zinc Finger E-box-Binding Homeobox 1
keywords: Epithelial-mesenchymal transition; LincRNA-ROR; Metastasis; Pancreatic cancer; ZEB1