title: Biodegradable Peptide-Silica Nanodonuts.
abstract: We report hybrid organosilica toroidal particles containing a short peptide sequence as the organic component of the hybrid systems. Once internalised in cancer cells, the presence of the peptide allows for interaction with peptidase enzymes, which attack the nanocarrier effectively triggering its structural breakdown. Moreover, these biodegradable nanovectors are characterised by high cellular uptake and exocytosis, showing great potential as biodegradable drug carriers. To demonstrate this feature, doxorubicin was employed and its delivery in HeLa cells investigated.
authors.affiliation: Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, 8 allée Gaspard Monge, 67000, Strasbourg, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Maggini
authors.affiliation: Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, 8 allée Gaspard Monge, 67000, Strasbourg, France.
authors.forename: Leana
authors.initials: L
authors.lastname: Travaglini
authors.affiliation: Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, 8 allée Gaspard Monge, 67000, Strasbourg, France.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Cabrera
authors.affiliation: Servei de Microscòpia, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Castro-Hartmann
authors.affiliation: Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, 8 allée Gaspard Monge, 67000, Strasbourg, France. decola@unistra.fr.|Institut für Nanotechnologie (INT), Karlsruhe Institute of Technology, Campus Nord, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany. decola@unistra.fr.
authors.forename: Luisa
authors.initials: L
authors.lastname: De Cola
mesh_terms: D000626:Aminopeptidases / Q000737:chemistry* / Q000378:metabolism; D004317:Doxorubicin / Q000737:chemistry*; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D010455:Peptides; D012822:Silicon Dioxide; D004317:Doxorubicin; D000626:Aminopeptidases
keywords: biodegradability; breakable particles; drug delivery; hybrid organosilica particles; materials science