title: Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats.
abstract: Alzheimer's disease is a progressive neurodegenerative disorder with decline in memory. The role of oxidative stress is well known in the pathogenesis of the disease. The purpose of this study was to evaluate pretreatment effects of oleuropein on oxidative status and cognitive dysfunction induced by colchicine in the hippocampal CA1 area. Male Wistar rats were pretreated orally once daily for 10 days with oleuropein at doses of 10, 15 and 20 mg/kg. Thereafter, colchicine (15 μg/rat) was administered into the CA1 area of the hippocampus to induce cognitive dysfunction. The Morris water maze was used to assess learning and memory. Biochemical parameters such as glutathione peroxidase and catalase activities, nitric oxide and malondialdehyde concentrations were measured to evaluate the antioxidant status in the rat hippocampus. Our results indicated that colchicine significantly impaired spatial memory and induced oxidative stress; in contrast, oleuropein pretreatment significantly improved learning and memory retention, and attenuated the oxidative damage. The results clearly indicate that oleuropein has neuroprotective effects against colchicine-induced cognitive dysfunction and oxidative damage in rats.
authors.affiliation: Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. s.porkhodadad@yahoo.com.
authors.forename: Soheila
authors.initials: S
authors.lastname: Pourkhodadad
authors.affiliation: Division of Biochemistry, School of Veterinary Medicine, Lorestan University, P.O. Box 465, Khorramabad, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Alirezaei
authors.affiliation: Department of Physiology and Pharmacology, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Mehrnoush
authors.initials: M
authors.lastname: Moghaddasi
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Ahmadvand
authors.affiliation: Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran.
authors.forename: Manizheh
authors.initials: M
authors.lastname: Karami
authors.affiliation: Department of Physiology and Pharmacology, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Bahram
authors.initials: B
authors.lastname: Delfan
authors.affiliation: Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Khanipour
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D056547:CA1 Region, Hippocampal / Q000187:drug effects* / Q000378:metabolism; D053148:Caspase 3 / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D060825:Cognitive Dysfunction / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D003078:Colchicine; D005979:Glutathione Peroxidase / Q000378:metabolism; D057888:Iridoid Glucosides; D039823:Iridoids / Q000494:pharmacology / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D065853:Spatial Learning / Q000187:drug effects*; D065852:Spatial Memory / Q000187:drug effects*
chemical_list: D057888:Iridoid Glucosides; D039823:Iridoids; D018696:Neuroprotective Agents; C002769:oleuropein; D009569:Nitric Oxide; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D053148:Caspase 3; D003078:Colchicine
keywords: Alzheimer’s disease; Colchicine; Hippocampus; Oleuropein; Oxidative stress