title: Nephrotic syndrome complicated with portal, splenic, and superior mesenteric vein thrombosis.
abstract: Thromboembolism is a major complication of nephrotic syndrome. Renal vein thrombosis and deep vein thrombosis are relatively common, especially in membranous nephropathy. However, the incidence of portal vein and superior mesenteric vein (SMV) thrombosis in patients with nephrotic syndrome is very rare. To date, several cases of portal vein thrombosis treated by anticoagulation therapy, not by thrombolytic therapy, have been reported as a complication of nephrotic syndrome. Here, we report a case of portal, splenic, and SMV thrombosis in a patient with a relapsed steroid dependent minimal change disease who was treated successfully with anticoagulation and thrombolytic therapy using urokinase. Radiologic findings and his clinical conditions gradually improved. Six months later, a complete remission of the nephrotic syndrome was observed and the follow-up computed tomography scan showed the disappearance of all portal vein, splenic vein, and SMV thrombi.
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Sihyung
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Kyubok
authors.initials: K
authors.lastname: Jin
authors.affiliation: Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Gibok
authors.initials: G
authors.lastname: Choi
authors.affiliation: Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Kang Min
authors.initials: KM
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Kyeong Min
authors.initials: KM
authors.lastname: Jo
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Yang Wook
authors.initials: YW
authors.lastname: Kim
keywords: Complications; Nephrotic syndrome; Thrombolytic therapy; Venous thrombosis