title: Clinical research of percutaneous bilateral splanchnic nerve lesion for pain relief in patients with pancreatic cancer under X-ray guidance.
abstract: OBJECTIVE
  to observe the therapeutic effects of percutaneous bilateral splanchnic nerves block in patients with intractable pain due to pancreatic cancer.
  
  
  METHODS
  twenty-fourpatients (advanced pancreatic cancer) with intractable pain were enrolled in the research. Through approach of the edge of T11 vertebral body with double-needle technique, the researchers carried out the bilateral lesion of the greater and the lesser splanchnic nerve with absolute ethyl alcohol under X-ray guidance. Follow-up was six months. Numerical rating scale (NRS) and quality of life (QOL) were all assessed pre- and post-procedure (1 d, 1 w, 2 w, 1 m, 2 m, 3 m, 4 m, 5 m, 6 m). The daily morphine consumption was recorded.
  
  
  RESULTS
  NRS and daily morphine consumption decreased when compared to pre-procedure while QOL increased. These differences were found to be statistically significant (P<0.05). 9 patients suffered from diarrhea temporally and recoveredin one week.
  
  
  CONCLUSIONS
  Percutaneous bilateral splanchnic nerves lesion under X-ray guidancecan treat intractable pain caused by pancreatic cancer and improve patients'life quality with minor complication.
authors.affiliation: Department of Anaesthesiology, Shanghai Tenth People's Hospital, Tongji University Shanghai 200072, China.
authors.forename: Minghui
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Anaesthesiology, Shanghai Tenth People's Hospital, Tongji University Shanghai 200072, China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Anaesthesiology, Shanghai Tenth People's Hospital, Tongji University Shanghai 200072, China.
authors.forename: Shiyu
authors.initials: S
authors.lastname: Sun
authors.affiliation: Department of Anaesthesiology, Shanghai Tenth People's Hospital, Tongji University Shanghai 200072, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Pan
authors.affiliation: Department of Anaesthesiology, Shanghai Tenth People's Hospital, Tongji University Shanghai 200072, China.
authors.forename: Zhengping
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Anaesthesiology, Shanghai Tenth People's Hospital, Tongji University Shanghai 200072, China.
authors.forename: Shukun
authors.initials: S
authors.lastname: Fu
authors.affiliation: Department of Anaesthesiology, Shanghai Tenth People's Hospital, Tongji University Shanghai 200072, China.
authors.forename: Fuqing
authors.initials: F
authors.lastname: Lin
keywords: The greater splanchnic nerve; absolute ethyl alcohol; cancer pain; pancreatic cancer; the lesser splanchnic nerve