title: The influence of common free radicals and antioxidants on development of Alzheimer's Disease.
abstract: Alzheimer's Disease (AD) is one of the most important neurodegenerative disorders in the 21st century for the continually aging population. Despite an increasing number of patients, there are only few drugs to treat the disease. Numerous studies have shown several causes of the disorder, one of the most important being oxidative stress. Oxidative stress is connected with a disturbance between the levels of free radicals and antioxidants in organisms. Solutions to this problem are antioxidants, which counteract the negative impact of the reactive molecules. Unfortunately, the currently available drugs against AD do not exhibit activity toward these structures. Due to the fact that natural substances are extremely significant in new drug development, numerous studies are focused on substances which exhibit a few activities including antioxidants and other anti-AD behaviors. This review article presents the most important studies connected with the influence of free radicals on development of AD and antioxidants as potential drugs toward AD.
authors.affiliation: Department of Inorganic Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland. Electronic address: k.wojtunik@o2.pl.
authors.forename: Karolina A
authors.initials: KA
authors.lastname: Wojtunik-Kulesza
authors.affiliation: Department of Inorganic Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland. Electronic address: anoniszczuk@o2.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Oniszczuk
authors.affiliation: Department of Food Process Engineering, Lublin University of Life Sciences, 44 Doświadczalna Street, 20-236 Lublin, Poland. Electronic address: tomasz.oniszczuk@up.lublin.pl.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Oniszczuk
authors.affiliation: Department of Inorganic Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland. Electronic address: monika.hajnos@am.lublin.pl.
authors.forename: Monika
authors.initials: M
authors.lastname: Waksmundzka-Hajnos
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D000975:Antioxidants / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species
keywords: Alzheimer’s Disease; Natural substances; Oxidative stress; Scavenging of free radicals