title: Vitamin D status in a Brazilian cohort of adolescents and young adults with perinatally acquired human immunodeficiency virus infection.
abstract: The purpose was to determine the prevalence and related factors of vitamin D (VitD) insufficiency in adolescents and young adults with perinatally acquired human immunodeficiency virus. A cohort of 65 patients (17.6 ± 2 years) at the Federal University of Rio de Janeiro, Brazil, were examined for pubertal development, nutrition, serum parathormone and serum 25-hydroxyvitamin D [s25(OH)D]. s25(OH)D levels < 30 ng/mL (< 75 nmol/L) were defined as VitD insufficiency. CD4+ T-cell counts and viral load, history of worst clinical status, immunologic status as nadir, current immunologic status, and antiretroviral (ART) regimen were also evaluated as risk factors for VitD insufficiency. Mean s25(OH)D was 37.7 ± 13.9 ng/mL and 29.2% had VitD insufficiency. There was no difference between VitD status and gender, age, nutritional status, clinical and immunological classification, and type of ART. Only VitD consumption showed tendency of association with s25(OH)D (p = 0.064). Individuals analysed in summer/autumn season had a higher s25(OH)D compared to the ones analysed in winter/spring (42.6 ± 14.9 vs. 34.0 ± 11.9, p = 0.011). Although, the frequency of VitD insufficiency did not differ statistically between the groups (summer/autumn 17.9% vs. winter/spring 37.8%, p = 0.102), we suggest to monitor s25(OH)D in seropositive adolescents and young adults, especially during winter/spring months, even in sunny regions.
authors.affiliation: Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Annie
authors.initials: A
authors.lastname: Schtscherbyna
authors.affiliation: Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Carla
authors.initials: C
authors.lastname: Gouveia
authors.affiliation: Laboratório Sérgio Franco, Rio de Janeiro, RJ, Brasil.
authors.forename: Maria Fernanda Miguens Castelar
authors.initials: MF
authors.lastname: Pinheiro
authors.affiliation: Instituto de Estudos em Saúde Coletiva, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Ronir Raggio
authors.initials: RR
authors.lastname: Luiz
authors.affiliation: Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Maria Lucia Fleiuss
authors.initials: ML
authors.lastname: Farias
authors.affiliation: Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Elizabeth Stankiewicz
authors.initials: ES
authors.lastname: Machado
mesh_terms: D000293:Adolescent; D044966:Anti-Retroviral Agents / Q000009:adverse effects*; D023241:Antiretroviral Therapy, Highly Active / Q000706:statistics & numerical data; D001938:Brazil / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005260:Female; D006679:HIV Seropositivity / Q000151:congenital* / Q000188:drug therapy; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D009752:Nutritional Status / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood; D015995:Prevalence; D012307:Risk Factors; D012621:Seasons; D018709:Statistics, Nonparametric; D013472:Sunlight; D019562:Viral Load; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000453:epidemiology* / Q000209:etiology; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents; D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D