title: Does plasma membrane lipid composition impact the miRNA-mediated regulation of vascular inflammation?
abstract: BACKGROUND
  Both PUFA and miRNAs are believed to be of importance in vascular diseases. On the one hand diverse nutrition societies recommend PUFA consumption to dampen inflammatory processes. On the other hand scientists intensify efforts to use miRNAs for diagnostics or therapy in context of vascular disorders.
  
  
  OBJECTIVE
  There might be is a causal link between the plasma membrane lipid composition and the miRNA expression of monocytes and endothelial cells. PUFA enrichment of cells may affect the type and the amount of particular miRNAs produced. In this way dietary fatty acids are supposed to impact the miRNA-mediated regulation of vascular inflammatory processes.
  PUFA-supplemented monocytes and endothelial cells are analyzed with respect to membrane fatty acid patterns, typical markers of vascular inflammation and miRNA expression. Experiments are performed both for undifferentiated/unstimulated as well as for differentiated/stimulated cells. Verification of identified miRNA targets is performed by means of mimics/antagomirs.
  
  
  CONCLUSIONS
  Innovative mechanism of action, which could point the way to a new understanding of the PUFA-mediated modulation of cellular signal transduction. If confirmed experimentally, it might stimulate vascular inflammation research and immunologic lipid science, hence, acting as source of inspiration for future therapeutic interventions in vascular diseases.
authors.affiliation: Clinic for Anesthesiology and Surgical Intensive Care, University Hospital Halle (Saale), Franzosenweg 1a, 06112 Halle (Saale), Germany. Electronic address: julia.schumann@uk-halle.de.
authors.forename: Julia
authors.initials: J
authors.lastname: Schumann
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008563:Membrane Lipids / Q000737:chemistry*; D035683:MicroRNAs / Q000378:metabolism*; D008962:Models, Theoretical; D009000:Monocytes / Q000166:cytology; D051381:Rats; D015398:Signal Transduction; D014652:Vascular Diseases / Q000276:immunology*
chemical_list: D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008563:Membrane Lipids; D035683:MicroRNAs