title: Mitochondrial Dysfunction Meets Senescence.
abstract: Cellular senescence and mitochondrial dysfunction are hallmarks of ageing, but until now their relationship has not been clear. Recent work by Wiley et al. shows that mitochondrial defects can cause a distinct senescence phenotype termed MiDAS (mitochondrial dysfunction-associated senescence). MiDAS has a specific secretome that is able to drive some of the aging phenotypes. These findings suggest novel therapeutic opportunities for treating age-related pathologies.
authors.affiliation: Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London W12 0NN, UK.
authors.forename: Suchira
authors.initials: S
authors.lastname: Gallage
authors.affiliation: Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London W12 0NN, UK. Electronic address: jesus.gil@csc.mrc.ac.uk.
authors.forename: Jesús
authors.initials: J
authors.lastname: Gil
mesh_terms: D000375:Aging; D016922:Cellular Senescence; D006801:Humans; D008928:Mitochondria; D010641:Phenotype
keywords: SASP; Senescence; Sirtuins; ageing; mitochondria; secretome