title: Therapeutic Effects of Erythroid Differentiation Regulator 1 on Imiquimod-Induced Psoriasis-Like Skin Inflammation.
abstract: Psoriasis is a common skin disease accompanied by chronic inflammation. In previous studies, erythroid differentiation regulator 1 (ERDR1) was shown to have a negative correlation with proinflammatory cytokine IL-18. However, the role of ERDR1 in the inflammatory skin disease psoriasis has not been evaluated. In this study, to investigate the role of ERDR1 in psoriasis, recombinant ERDR1 was injected intraperitoneally into a psoriasis mouse model. Recombinant ERDR1 (rERDR1) significantly alleviated the symptoms of psoriasis-like skin inflammation and reduced the mRNA of various psoriasis-related markers, including keratin 14, S100A8, and Th17-related cytokines IL-17 and IL-22, suggesting that rERDR1 exerts therapeutic effects on psoriasis via the regulation of Th17 functions. Additionally, the expression of CCL20, a well-known Th17 attracting chemokine, was determined. CCL20 expression significantly decreased in the rERDR1-injected group compared with the vehicle (PBS)-injected group. CCR6 expression in the psoriatic lesional skin was also decreased by rERDR1 administration, implying the inhibition of CCR6-expressing Th17 cell chemotaxis via the downregulation of CCL20. Taken together, this study provides the first evidence that ERDR1 may be a potential therapeutic target for psoriasis.
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Chungpa-Dong 2-Ka, Yongsan-ku, Seoul 140-742, Korea. kyungeun@sookmyung.ac.kr.
authors.forename: Kyung Eun
authors.initials: KE
authors.lastname: Kim
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Chungpa-Dong 2-Ka, Yongsan-ku, Seoul 140-742, Korea. hyk-602@daum.net.
authors.forename: Younkyung
authors.initials: Y
authors.lastname: Houh
authors.affiliation: Department of Dermatology, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul 150-713, Korea. hjpark@catholic.ac.kr.
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Chungpa-Dong 2-Ka, Yongsan-ku, Seoul 140-742, Korea. cdhkor@sookmyung.ac.kr.
authors.forename: Daeho
authors.initials: D
authors.lastname: Cho
mesh_terms: D000634:Aminoquinolines / Q000009:adverse effects*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000494:pharmacology; D040501:Calgranulin A / Q000235:genetics; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000187:drug effects; D000077271:Imiquimod; D020381:Interleukin-17 / Q000235:genetics; D007378:Interleukins / Q000235:genetics; D008565:Membrane Proteins / Q000008:administration & dosage* / Q000235:genetics / Q000494:pharmacology; D051379:Mice; D011565:Psoriasis / Q000139:chemically induced / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000235:genetics / Q000494:pharmacology; D058504:Th17 Cells / Q000187:drug effects / Q000276:immunology; D025521:Tumor Suppressor Proteins / Q000008:administration & dosage* / Q000235:genetics / Q000494:pharmacology; D000097043:Interleukin-22
chemical_list: D000634:Aminoquinolines; D000893:Anti-Inflammatory Agents; D040501:Calgranulin A; D000077271:Imiquimod; D020381:Interleukin-17; D007378:Interleukins; D008565:Membrane Proteins; D011994:Recombinant Proteins; D025521:Tumor Suppressor Proteins; D000097043:Interleukin-22; C086145:S100a8 protein, mouse; C583413:erythroid differentiation regulator 1, human
keywords: CCL20; CCR6; ERDR1; Th17; inflammatory skin diseases; psoriasis