title: Association between Functional MICA-TM and Behcet's Disease: A Systematic Review and Meta-analysis.
abstract: The relationships between polymorphisms of the trans-membrane(TM) region located in the major histocompatibility complex (MHC) class I chain-related gene A (MICA) and Behcet's disease (BD) have been discussed previously, however, the results were contradictory. In this study, we thoroughly assess whether MICA-TM gene variants are associated with BD by means of a systematic review and meta-analysis. Our study focused on the effects of polymorphisms of MICA-A4, A5, A5.1, A6, and A9 from the included articles. Sixteen previous original publications representing 1,555 BD patients and 2,086 unrelated healthy controls analyzed the association of BD with MICA-TM gene polymorphisms. For the five alleles, MICA-A6 showed a strongly positive correlation with BD patients and could be viewed as an increased risk factor of BD (OR = 2.34, 95%CI: 2.02-2.70). Furthermore, MICA-A4, A5, A5.1, and A9 exhibited negative associations with BD (OR = 0.71, 95%CI: 0.58-0.86; OR = 0.75, 95%CI: 0.63-0.90; OR = 0.63, 95%CI: 0.44-0.91; OR = 0.70, 95%CI: 0.58-0.84, respectively). Our meta-analysis confirmed MICA-A6 could be responsible for BD in three ethnic regions and should probably be treated as a risk factor for BD. MICA-A4, A5, A5.1, and A9 could be regarded as protective factors, especially in the Middle East and East Asia.
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.|Chongqing Eye Institute and Chongqing Key Laboratory of Ophthalmology, Chongqing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.|Chongqing Eye Institute and Chongqing Key Laboratory of Ophthalmology, Chongqing, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liao
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.|Chongqing Eye Institute and Chongqing Key Laboratory of Ophthalmology, Chongqing, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.|Chongqing Eye Institute and Chongqing Key Laboratory of Ophthalmology, Chongqing, China.
authors.forename: Shengping
authors.initials: S
authors.lastname: Hou
mesh_terms: D000483:Alleles; D001528:Behcet Syndrome / Q000235:genetics* / Q000473:pathology; D005006:Ethnicity / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A