title: Schizocalyx cuspidatus (A. St.-Hil.) Kainul. & B. Bremer extract improves antioxidant defenses and accelerates the regression of hepatic fibrosis after exposure to carbon tetrachloride in rats.
abstract: The aim of this study was to investigate the effect of leaves extract of Schizocalyx cuspidatus (A. St.-Hil.) Kainul. & B. Bremer on hepatic morphofunctional dysfunction induced by carbon tetrachloride (CCl4). Liver lesions were induced via intraperitoneal administration of CCl4every 48 h for 12 days. Forty-nine rats were randomised into seven groups: G1: CCl4; G2: CCl4(animals euthanised 24 h after last CCl4application); G3: CCl4+ DMSO; G4: SCE 400 mg/kg; G5: DMSO (700 μl); G6: CCl4+ SCE 200 mg/kg and G7: CCl4+ SCE 400 mg/kg. SCE administration resulted in reduction in hydroperoxide levels, lipidic droplets and necrosis compared to G1, G2 and G3. There was an increase in the amount of collagen fibres in G1, G2 and G3 compared to the groups. These results show that the extract of SCE leaves has great potential for the recovery of liver damage after the application of CCl4.
authors.affiliation: a Department of Animal Biology , Federal University of Viçosa , Viçosa , Brazil.
authors.forename: Reggiani Vilela
authors.initials: RV
authors.lastname: Gonçalves
authors.affiliation: b Department of Structural Biology, Institute of Biomedical Sciences , Federal University of Alfenas , Alfenas , Brazil.
authors.forename: Rômulo Dias
authors.initials: RD
authors.lastname: Novaes
authors.affiliation: c Department of General Biology , Federal University of Viçosa , Viçosa , Brazil.
authors.forename: Mariáurea Matias
authors.initials: MM
authors.lastname: Sarandy
authors.affiliation: d Department of Biochemistry and Molecular Biology , Federal University of Viçosa , Viçosa , Brazil.
authors.forename: João Paulo Viana
authors.initials: JPV
authors.lastname: Leite
authors.affiliation: e Department of Fitotecnia , Federal University of Viçosa , Viçosa , Brazil.
authors.forename: Emerson Ferreira
authors.initials: EF
authors.lastname: Vilela
authors.affiliation: c Department of General Biology , Federal University of Viçosa , Viçosa , Brazil.
authors.forename: Marli do Carmo
authors.initials: MDC
authors.lastname: Cupertino
authors.affiliation: c Department of General Biology , Federal University of Viçosa , Viçosa , Brazil.
authors.forename: Sérgio Luis Pinto
authors.initials: SLP
authors.lastname: da Matta
keywords: Fibrosis; antioxidant activity; carbon tetrachloride; hepatotoxicity