title: Osteosarcoma of larynx: A rare case report with review of literature.
abstract: Laryngeal osteosarcoma is an extremely rare and aggressive malignancy. Only very few cases of primary laryngeal osteosarcomas are reported in literature, and all have a dismal prognosis. A 50-year-old male presented with recurrent hoarseness of voice and was evaluated and diagnosed as sarcoma larynx. Detailed histopathology report of laryngectomy specimen revealed presence of osteoid, which confirmed the diagnosis of osteosarcoma larynx. He was further treated with adjuvant chemotherapy and radiation and is disease free after 9 months. Surgery remains the mainstay of treatment in this disease and role of adjuvant chemotherapy and radiotherapy is still evolving.
authors.forename: Amit
authors.initials: A
authors.lastname: Bahl
authors.forename: Philip
authors.initials: P
authors.lastname: George
authors.affiliation: Department of Radiotherapy and Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Tapesh
authors.initials: T
authors.lastname: Bhattacharyya
authors.forename: Sushmita
authors.initials: S
authors.lastname: Ghoshal
authors.forename: Jaymanti
authors.initials: J
authors.lastname: Bakshi
authors.forename: Ashim
authors.initials: A
authors.lastname: Das
mesh_terms: D001859:Bone Neoplasms / Q000473:pathology* / Q000628:therapy; D059248:Chemoradiotherapy; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000473:pathology* / Q000628:therapy; D011379:Prognosis