title: The Intensive Care Global Study on Severe Acute Respiratory Infection (IC-GLOSSARI): a multicenter, multinational, 14-day inception cohort study.
abstract: OBJECTIVE
  In this prospective, multicenter, 14-day inception cohort study, we investigated the epidemiology, patterns of infections, and outcome in patients admitted to the intensive care unit (ICU) as a result of severe acute respiratory infections (SARIs).
  
  
  METHODS
  All patients admitted to one of 206 participating ICUs during two study weeks, one in November 2013 and the other in January 2014, were screened. SARI was defined as possible, probable, or microbiologically confirmed respiratory tract infection with recent onset dyspnea and/or fever. The primary outcome parameter was in-hospital mortality within 60 days of admission to the ICU.
  
  
  RESULTS
  Among the 5550 patients admitted during the study periods, 663 (11.9 %) had SARI. On admission to the ICU, Gram-positive and Gram-negative bacteria were found in 29.6 and 26.2 % of SARI patients but rarely atypical bacteria (1.0 %); viruses were present in 7.7 % of patients. Organ failure occurred in 74.7 % of patients in the ICU, mostly respiratory (53.8 %), cardiovascular (44.5 %), and renal (44.6 %). ICU and in-hospital mortality rates in patients with SARI were 20.2 and 27.2 %, respectively. In multivariable analysis, older age, greater severity scores at ICU admission, and hematologic malignancy or liver disease were independently associated with an increased risk of in-hospital death, whereas influenza vaccination prior to ICU admission and adequate antibiotic administration on ICU admission were associated with a lower risk.
  
  
  CONCLUSIONS
  Admission to the ICU for SARI is common and associated with high morbidity and mortality rates. We identified several risk factors for in-hospital death that may be useful for risk stratification in these patients.
authors.affiliation: Department of Anesthesiology and Intensive Care, Uniklinikum Jena, Erlanger Allee 103, 07743, Jena, Germany. yasser.sakr@med.uni-jena.de.
authors.forename: Yasser
authors.initials: Y
authors.lastname: Sakr
authors.affiliation: Intensive Care Department, Hospital Universitari Vall d'Hebron, CIBER Enfermedades Respiratorias, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain.
authors.forename: Ricard
authors.initials: R
authors.lastname: Ferrer
authors.affiliation: Department of Anesthesiology and Intensive Care, Uniklinikum Jena, Erlanger Allee 103, 07743, Jena, Germany.
authors.forename: Konrad
authors.initials: K
authors.lastname: Reinhart
authors.affiliation: King's Health Partners, Westminster Bridge Road, London, SE1 7EH, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Beale
authors.affiliation: Critical Care Directorate, St George's University Hospitals NHS Foundation Trust, London, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Rhodes
authors.affiliation: Intensive Care Unit, Hospital de São Jos, Unidade de Cuidados Intensivos Neurocríticos, Centro Hospitalar de Lisboa Central, EPE, Rua José António Serrano, s, 1150-199, Lisbon, Portugal.
authors.forename: Rui
authors.initials: R
authors.lastname: Moreno
authors.affiliation: Medical ICU, Paris Diderot University/Bichat Teaching Hospital Medical and Infectious Diseases ICU, 46 rue Henri Huchard, Paris, 75018, France.
authors.forename: Jean Francois
authors.initials: JF
authors.lastname: Timsit
authors.affiliation: Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.|Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.
authors.forename: Laurent
authors.initials: L
authors.lastname: Brochard
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, USA.|Harvard Medical School, 55 Fruit St, Boston, MA, 02114, USA.
authors.forename: B Taylor
authors.initials: BT
authors.lastname: Thompson
authors.affiliation: Serviço de Terapia intensiva na IAMSPE-Instituto de Assistência Médica ao Servidor Público Estadual, Av. Ibirapuera, 981, São Paulo, SP, 04028-000, Brazil.
authors.forename: Ederlon
authors.initials: E
authors.lastname: Rezende
authors.affiliation: Medical Intensive Care Unit, Paris Descartes University, Paris, France.|Hôpital Cochin, Paris, France.|Department of Cell Biology and Host-Pathogen Interaction, Cochin Institute, 27 Rue du Faubourg St Jacques, 75679, Paris Cedex 14, France.
authors.forename: Jean Daniel
authors.initials: JD
authors.lastname: Chiche
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis / Q000382:microbiology / Q000401:mortality / Q000628:therapy*; D012720:Severity of Illness Index
keywords: Intensive care; Outcome; Pneumonia; Severe acute respiratory infections