title: Effect of single-dose albendazole and vitamin A supplementation on the iron status of pre-school children in Sichuan, China.
abstract: The aim of this study was to explore the effect of single-dose albendazole and vitamin A intervention on the anaemic status and Fe metabolism of pre-school children. This study was a randomised, placebo-controlled and double-blinded intervention trial. All eligible anaemic pre-school children were randomly divided into three groups: group 1 received no intervention, which served as the control group, group 2 received 400 mg single-dose albendazole administration and group 3 received a 60000 μg vitamin A capsule combined with 400 mg single-dose albendazole at the beginning of the study. The follow-up period was for 6 months. Anthropometry and biochemical index about Fe metabolism were measured before and after intervention. A total of 209 pre-school anaemic children were randomly divided into three intervention groups (sixty-four, sixty-two and sixty for groups 1, 2 and 3, respectively). The mean age of the children in the study was 4·4 (sd 0·7) years and 50·5 % of the children were female (94/186). After a follow-up period of 6 months, the levels of serum retinol, ferritin, transferrin receptor-ferritin index and body total Fe content of children in group 3 were significantly higher compared with children in groups 1 and 2 (P<0·05). Moreover, the proportion of vitamin A deficiency, marginal vitamin A deficiency and Fe deficiency among children in group 3 were markedly lower compared with children in groups 1 and 2 (P<0·05). Albendazole plus vitamin A administration showed more efficacy on the improvement of serum retinol and Fe metabolic status.
authors.affiliation: Department of Nutrition,Chengdu Women & Children's Central Hospital,No. 1617,Riyue Street,Qingyang District,Chengdu,Sichuan 610091,People's Republic of China.
authors.forename: Ke
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Nutrition,Chengdu Women & Children's Central Hospital,No. 1617,Riyue Street,Qingyang District,Chengdu,Sichuan 610091,People's Republic of China.
authors.forename: Hu Mina
authors.initials: HM
authors.lastname: Xie
authors.affiliation: Department of Nutrition,Chengdu Women & Children's Central Hospital,No. 1617,Riyue Street,Qingyang District,Chengdu,Sichuan 610091,People's Republic of China.
authors.forename: Weizheng
authors.initials: W
authors.lastname: Tian
authors.affiliation: Department of Nutrition,Chengdu Women & Children's Central Hospital,No. 1617,Riyue Street,Qingyang District,Chengdu,Sichuan 610091,People's Republic of China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Department of Nutrition,Chengdu Women & Children's Central Hospital,No. 1617,Riyue Street,Qingyang District,Chengdu,Sichuan 610091,People's Republic of China.
authors.forename: Alice C
authors.initials: AC
authors.lastname: Jiang
mesh_terms: D015766:Albendazole / Q000008:administration & dosage*; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology / Q000469:parasitology; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy; D000871:Anthelmintics; D000886:Anthropometry; D002648:Child; D002675:Child, Preschool; D002681:China; D004311:Double-Blind Method; D005260:Female; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006725:Hookworm Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008297:Male; D010919:Placebos; D011990:Receptors, Transferrin / Q000097:blood; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014801:Vitamin A / Q000008:administration & dosage* / Q000097:blood; D014802:Vitamin A Deficiency / Q000150:complications / Q000188:drug therapy
chemical_list: D000871:Anthelmintics; D006454:Hemoglobins; D010919:Placebos; D011990:Receptors, Transferrin; D014801:Vitamin A; D005293:Ferritins; D015766:Albendazole
keywords: Albendazole; Anaemia; CRP C-reaction protein; Children; ID Fe deficiency; Iron metabolism; MVAD marginal vitamin A deficiency; SF serum ferritin; SNK Student–Newman–Keuls; TBIC total body Fe content; TFR-F index transferrin receptor-ferritin index; VAD vitamin A deficiency; Vitamin A; sTfR serum soluble transferrin receptor