title: Cesarean section delivery and development of food allergy and atopic dermatitis in early childhood.
abstract: Delivery by Cesarean section (CS) may predispose to allergic disorders, presumably due to alterations in the establishment of normal gut microbiota in early infancy. In this study, we sought to investigate the association between CS and physician-diagnosed food allergy and atopic dermatitis during the first 3 years of life, using data from a homogeneous, population-based, birth cohort.
  
  
  
  A total of 459 children born and cared for in the same tertiary maternity unit were examined at birth and followed up at 1, 6, 12, 18, 24, 30 and 36 months of age. Participants with symptoms suggestive of food allergy or atopic dermatitis were evaluated by a pediatric allergy specialist to confirm the diagnosis based on well-defined criteria.
  
  
  
  The rate of CS was 50.8% (n = 233). Food allergy was diagnosed in 24 participants (5.2%) while atopic dermatitis was diagnosed in 62 children (13.5%). Cesarean section (OR 3.15; 95% CI 1.14-8.70), atopic dermatitis of the child (OR 3.01; 95% CI 1.18-7.80), parental atopy (OR 4.33; 95% CI 1.73-12.1), and gestational age (OR 1.57; 95% CI 1.07-2.37) were significant and independent predictors of food allergy. Children with at least one allergic parent delivered by CS had higher probability of developing food allergy compared with vaginally delivered children of non-allergic parents (OR 10.0; 95% CI 3.06-32.7). Conversely, the effect of CS on atopic dermatitis was not significant (OR 1.35; 95% CI 0.74-2.47).
  
  
  
  Delivery by CS predisposes to the development of food allergy but not atopic dermatitis in early childhood. Cesarean section delivery seems to upregulate the immune response to food allergens, especially in children with allergic predisposition.
authors.affiliation: Department of Pediatrics, University of Patras Medical School, Patras, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Papathoma
authors.affiliation: Department of Pediatrics, University of Patras Medical School, Patras, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Triga
authors.affiliation: Department of Pediatrics, University of Patras Medical School, Patras, Greece.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Fouzas
authors.affiliation: Department of Pediatrics, University of Patras Medical School, Patras, Greece.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Dimitriou
mesh_terms: D000328:Adult; D000367:Age Factors; D002585:Cesarean Section / Q000009:adverse effects*; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D006115:Greece / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D011247:Pregnancy; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
keywords: Cesarean section; atopic dermatitis; food allergy