title: Predictive potential role of GSTs gene polymorphisms in the treatment outcome of advanced non-small cell lung cancer patients.
abstract: This study aimed to investigate the possible association between GSTP1, GSTM1, and GSTT1 polymorphisms and treatment outcome of advanced NSCLC. Between October 2009 and October 2011, a total of 308 patients of NSCLC on stage IIIA, IIIB or IV, treated with cisplatin-based chemotherapy were included. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype the GSTP1 and GSTM1, and GSTT1 polymorphisms. We found that the IIe/Val and Val/Val genotypes of GSTP1 showed more CR+PR to chemotherapy in advanced NSCLC when compared with IIe/IIe genotype, and the Ors (95% CI) were 0.37 (0.18-0.71) and 0.15 (0.07-0.38). The IIe/Val and Val/Val genotypes of GSTP1 were associated with longer overall survival of advanced NSCLC when compared with the IIe/IIe genotype (For IIe/Val vs IIe/IIe, 37.63 ± 2.01 months vs 30.25 ± 2.06 months; for Val/Val vs IIe/IIe, 39.84 ± 3.36 months vs 30.25 ± 2.06 months). In the Cox proportional hazards model, the IIe/Val and Val/Val genotypes significantly decreased risk of death from all causes in patients with advanced NSCLC, and the HRs (95% CIs) were 0.51 (0.28-0.94) and 0.35 (0.16-0.78), respectively. We found that the GSTP1 polymorphisms might affect the clinical outcome of patients with advanced NSCLC, and our results could help us to facilitate therapeutic decision for individualized therapy.
authors.affiliation: Department of Respiratory Disease, The First Affiliated Hospital, Fujian Medical University Fuzhou 350005, China.
authors.forename: Kaixiong
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Respiratory Disease, The First Affiliated Hospital, Fujian Medical University Fuzhou 350005, China.
authors.forename: Qichang
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Department of Respiratory Disease, The First Affiliated Hospital, Fujian Medical University Fuzhou 350005, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Ding
authors.affiliation: Department of Respiratory Disease, The First Affiliated Hospital, Fujian Medical University Fuzhou 350005, China.
authors.forename: Yongxu
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Department of Respiratory Disease, The First Affiliated Hospital, Fujian Medical University Fuzhou 350005, China.
authors.forename: Gongping
authors.initials: G
authors.lastname: Chen
keywords: GSTM1; GSTP1; GSTT1; NSCLC; polymorphism