title: Pregnancy outcomes in women with endometriosis: a national record linkage study.
abstract: OBJECTIVE
  To determine pregnancy outcomes in women with endometriosis.
  
  
  METHODS
  A national population based cohort study using record linkage.
  
  
  METHODS
  Scotland.
  
  
  METHODS
  A cohort of 14 655 women followed up over a 30-year period (1981-2010).
  
  
  METHODS
  In a nationwide Scottish study, we compared pregnancy outcomes in 5375 women with surgically confirmed endometriosis with outcomes in 8710 women without endometriosis who were pregnant during the same time period. Data were analysed using univariable and multivariable logistic regression after adjusting for confounding factors.
  
  
  METHODS
  Outcome measures evaluated included miscarriage, ectopic pregnancy, stillbirths and other pregnancy complications such as hypertensive disorders of pregnancy, antepartum and postpartum haemorrhage, operative delivery and preterm births. The outcomes were presented as adjusted odds ratios (OR) with 95% confidence intervals (CI).
  
  
  RESULTS
  On multivariable analysis, after adjusting for age, parity, socio-economic status and year of delivery, women with endometriosis when compared to women without endometriosis, had a significantly higher risk of early pregnancy complications with adjusted OR (95% CI) of 1.76 (1.44, 2.15) and 2.70 (1.09, 6.72) for miscarriage and ectopic pregnancy, respectively. A previous diagnosis of endometriosis was associated with a significantly increased risk of [adjusted OR (95% CI)] placenta praevia [2.24 (1.52, 3.31)], unexplained antepartum haemorrhage [1.67 (1.39, 2.00)], postpartum haemorrhage [1.30 (1.61, 1.46)] and preterm births [1.26 (1.07, 1.49)] in pregnancies progressing beyond 24 weeks.
  
  
  CONCLUSIONS
  Endometriosis predisposes women to an increased risk of early pregnancy loss and later pregnancy complications.
  
  
  CONCLUSIONS
  Endometriosis predisposes women to an increased risk of early pregnancy loss and later pregnancy complications.
authors.affiliation: Ward 315, Department of Gynaecology, Aberdeen Royal Infirmary, Aberdeen, UK.
authors.forename: L
authors.initials: L
authors.lastname: Saraswat
authors.affiliation: Medical Statistics Team, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
authors.forename: D T
authors.initials: DT
authors.lastname: Ayansina
authors.affiliation: Ward 315, Department of Gynaecology, Aberdeen Royal Infirmary, Aberdeen, UK.
authors.forename: K G
authors.initials: KG
authors.lastname: Cooper
authors.affiliation: Dugald Baird Centre, Aberdeen Maternity Hospital, Aberdeen, UK.
authors.forename: S
authors.initials: S
authors.lastname: Bhattacharya
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospitals of Southampton, Southampton, UK.
authors.forename: D
authors.initials: D
authors.lastname: Miligkos
authors.affiliation: MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
authors.forename: A W
authors.initials: AW
authors.lastname: Horne
authors.affiliation: Head of Division of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK.
authors.forename: S
authors.initials: S
authors.lastname: Bhattacharya
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004715:Endometriosis / Q000150:complications*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012606:Scotland / Q000453:epidemiology; D055815:Young Adult
keywords: Endometriosis; early pregnancy outcomes; late pregnancy complications