title: Effect of Cigarette Smoke on Salivary Total Antioxidant Capacity.
abstract: Background and aims. Cigarette smoke can induce oral cancer by its free radicals and oxidative damage. Salivary anti-oxidants system is believed to have an important role in defense mechanisms against oxidative stress. This study was compared total antioxidant capacity (TAoC) of saliva in smokers and nonsmokers. Materials and methods . In this cross-sectional study, 30 male smokers with mean age of 45.23 years and 30 nonsmokers with mean age of 45.30 years participated. Unstimulated whole saliva samples were collected in the morning in two groups by spitting method. TAoC of saliva was measured with the special kit in two groups at the same time. Statistical analysis was performed by covariance test. Results. The mean salivary TAoC in nonsmokers (0.741±0.123 U/ml) was higher than that in smokers (0.529±0.167 U/ml). This difference was statistically significant (P<0.001). Conclusion. Smoking can alter salivary antioxidant capacity.
authors.affiliation: Associate Professor, Department of Oral medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Bakhtiari
authors.affiliation: Assistant Professor, Department of Oral medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Honorary Research Fellow, University of Western Australia, Perth, Australia.
authors.forename: Somayyeh
authors.initials: S
authors.lastname: Azimi
authors.affiliation: Associate Professor, Department of Oral medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Mehdipour
authors.affiliation: Dentist, Private Practice, Tehran, Iran.
authors.forename: Somayyeh
authors.initials: S
authors.lastname: Amini
authors.affiliation: Post-graduate Student, Department of Oral medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Elmi
authors.affiliation: PHD Student, Department of Dental Materials, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Namazi
keywords: Antioxidant; saliva; smoking