title: Potential mechanisms underlying the Runx2 induced osteogenesis of bone marrow mesenchymal stem cells.
abstract: Bone marrow derived mesenchymal stem cells (BM-MSCs) belong a type of pluripotent stem cells and can be induced to differentiate into osteoblasts (OB). Runt-related transcription factor 2 (Runx2) is an osteogenesis specific transcription factor and plays an important role in osteogenesis of BM-MSCs. It can promote the expression of osteogenesis related genes, regulate cell cycle progression, improve bone microenvironment and affect functions of chondrocytes and osteoclasts, which have involvement of a large amount of signal molecules including TGF-β, BMP, Notch, Wnt, Hedgehog, FGF and microRNA. In this paper, we summarize the mechanisms underlying the Runx2 induced osteogenesis of BM-MSCs.
authors.affiliation: Deapartment of Orthopedics, Renmin Hospital of Wuhan University Wuhan 430060, China.
authors.forename: Jiahai
authors.initials: J
authors.lastname: Xu
authors.affiliation: Deapartment of Orthopedics, Renmin Hospital of Wuhan University Wuhan 430060, China.
authors.forename: Zhanghua
authors.initials: Z
authors.lastname: Li
authors.affiliation: Deapartment of Orthopedics, Renmin Hospital of Wuhan University Wuhan 430060, China.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Deapartment of Orthopedics, Renmin Hospital of Wuhan University Wuhan 430060, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Fang
keywords: Bone marrow derived mesenchymal stem cells; Runx2; osteogenic differentiation