title: Aptamer-based 'point-of-care testing'.
abstract: Aptamers are single-stranded oligonucleotides that can be artificially generated by a method called Systematic evolution of ligands by exponential enrichment (SELEX). The generated aptamers have been assessed for high-performance sensing applications due to their appealing characteristics. With either aptamers alone or complementing with antibodies, several high sensitive and portable sensors have been demonstrated for use in 'point-of-care testing'. Due to their high suitability and flexibility, aptamers are conjugated with nanostructures and utilized in field applications. Moreover, aptamers are more amenable to chemical modifications, making them capable of utilization with most developed sensors. In this overview, we discuss novel, portable, and aptamer-based sensing strategies that are suitable for 'point-of-care testing'.
authors.affiliation: Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis, 01000 Kangar, Perlis, Malaysia; School of Bioprocess Engineering, Universiti Malaysia Perlis, 02600 Arau, Perlis, Malaysia. Electronic address: subash@unimap.edu.my.
authors.forename: Subash C B
authors.initials: SC
authors.lastname: Gopinath
authors.affiliation: Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis, 01000 Kangar, Perlis, Malaysia.
authors.forename: Thangavel
authors.initials: T
authors.lastname: Lakshmipriya
authors.affiliation: Department of Oral Biology & Biomedical Sciences and OCRCC, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Yeng
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Oral Biology & Biomedical Sciences and OCRCC, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Wai-Mei
authors.initials: WM
authors.lastname: Phang
authors.affiliation: Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis, 01000 Kangar, Perlis, Malaysia.
authors.forename: Uda
authors.initials: U
authors.lastname: Hashim
mesh_terms: D052157:Aptamers, Nucleotide; D001419:Bacteria / Q000302:isolation & purification; D006801:Humans; D008567:Membranes, Artificial; D019095:Point-of-Care Systems; D052156:SELEX Aptamer Technique; D000068997:Smartphone; D020349:Surface Plasmon Resonance; D014780:Viruses / Q000302:isolation & purification
chemical_list: D052157:Aptamers, Nucleotide; D008567:Membranes, Artificial
keywords: Antibody; Aptamer; Portable; SELEX; Sensor