title: Intratympanic corticosteroid for sudden hearing loss: does it really work?
abstract: BACKGROUND
  Sudden deafness is characterized by an abrupt hearing loss of at least 30dB in three sequential frequencies in the standard pure tone audiogram over three days or less. Treatment is based on its etiology, and oral corticosteroids are widely used. Intratympanic corticosteroids are included as primary or secondary treatment when there is no improvement with the use of oral corticosteroids.
  
  
  OBJECTIVE
  To determine the effectiveness of therapy with intratympanic steroids in sudden deafness.
  
  
  METHODS
  A systematic review was performed of publications on the topic in the databases of PubMed/MEDLINE, with the keywords: sudden deafness, sudden hearing loss, and corticosteroids.
  
  
  RESULTS
  Thirty scientific studies were analyzed. As to the objectives of the study analyzed, 76.7% sought to evaluate the use of intratympanic therapy salvage after failure to conventional treatment, and intratympanic therapy was used as the primary treatment 23.3% of the studies.
  
  
  CONCLUSIONS
  Intratympanic corticosteroid therapy is prescribed primarily when there is failure of conventional therapy and when it is limited to use systemic corticosteroids, such as the diabetic patient.
authors.affiliation: Postgraduate Speech and Hearing, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil; Educational Psychology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Audiology and Neurotology, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil; Universidade de Brasília (UnB), Brasília, DF, Brazil.
authors.forename: Monique Antunes de Souza Chelminski
authors.initials: MA
authors.lastname: Barreto
authors.affiliation: Universidade de Brasília (UnB), Brasília, DF, Brazil.
authors.forename: Aleluia Lima Losno
authors.initials: AL
authors.lastname: Ledesma
authors.affiliation: Universidade de Brasília (UnB), Brasília, DF, Brazil.
authors.forename: Carlos Augusto Costa Pires
authors.initials: CA
authors.lastname: de Oliveira
authors.affiliation: Otology and Neurotology, Harvard Medical School, Boston, USA. Electronic address: fayez@gmail.com.
authors.forename: Fayez
authors.initials: F
authors.lastname: Bahmad
mesh_terms: D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D003639:Hearing Loss, Sudden / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D000069555:Injection, Intratympanic; D008775:Methylprednisolone / Q000008:administration & dosage*; D016896:Treatment Outcome; D014432:Tympanic Membrane
chemical_list: D000305:Adrenal Cortex Hormones; D003907:Dexamethasone; D008775:Methylprednisolone
keywords: Corticosteroides; Corticosteroids; Perda súbita da audição; Sudden deafness; Sudden hearing loss; Surdez súbita