title: The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people.
abstract: BACKGROUND
  To investigate the possible association of the Klotho G-395A polymorphism and metabolic syndrome (MetS) among a population of Chinese nonagenarians and centenarians.
  
  
  METHODS
  Subjects were from the Project of Longevity and Aging in Dujiangyan (PLAD). The genotyping of G-395A (rs1207568) in the promoter region of the Klotho gene was performed using the TaqMan allelic discrimination assay. MetS was diagnosed according to the International Diabetes Federation criteria.
  
  
  RESULTS
  We included 695 subjects aged 93.5 ± 3.2 years. G and A allele frequencies were 0.852 and 0.148, respectively. In the whole population, the frequency of MetS was 10.8% and 5.9% in the GG and GA + AA genotype group, respectively (p = 0.004). The -395A allele carriers had significantly lower risk of MetS in the whole population (odd ratio [OR] 0.50, 95% confidential interval [CI] 0.25 to 0.98) and in women (OR 0.51, 95% CI 0.24 to 0.97), but not in men (OR 0.42, 95% CI 0.05 to 3.85). In the whole population and women, the relationship between the Klotho G-395A SNP and MetS might due to its influence on high blood pressure (OR 0.48, 95% CI 0.34 to 0.67; OR 0.47, 95% CI 0.31 to 0.71, respectively) and hypertriglyceridemia (OR 0.66, 95% CI 0.39 to 0.95; OR 0.54, 95% CI 0.31 to 0.98, respectively). In men, this relationship might due to its influence on high blood pressure (OR 0.47, 95% CI 0.25 to 0.90) and low HDL-C (OR 0.69, 95% CI 0.27 to 0.93).
  
  
  CONCLUSIONS
  The -395A allele carriers of the Klotho gene were correlated with lower risk of MetS among Chinese nonagenarians and centenarians, especially in women.
authors.affiliation: The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, No.37 Guoxue Lane, Chengdu, Sichuan, China. 78847017@qq.com.
authors.forename: Li
authors.initials: L
authors.lastname: Luo
authors.affiliation: The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, No.37 Guoxue Lane, Chengdu, Sichuan, China. haoqiukui@126.com.
authors.forename: Qiukui
authors.initials: Q
authors.lastname: Hao
authors.affiliation: The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, No.37 Guoxue Lane, Chengdu, Sichuan, China. birongdong@163.com.
authors.forename: Birong
authors.initials: B
authors.lastname: Dong
authors.affiliation: The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, No.37 Guoxue Lane, Chengdu, Sichuan, China. yangmier@126.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D005966:Glucuronidase / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D000090265:Klotho Proteins; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D005966:Glucuronidase; D000090265:Klotho Proteins