title: Atypical skin reaction in a patient treated with gefitinib for advanced lung cancer: A case report and review of the literature.
abstract: Gefitinib is a selective epidermal growth factor receptor tyrosine kinase inhibitor utilized for the treatment of advanced non-small cell lung carcinoma. The most commonly reported adverse event during gefitinib therapy is skin rash, particularly a papulopustular acne-like eruption. Cutaneous toxicities can affect treatment compliance and the quality of life of the patient. The present study reports a case of gefitinib-induced atypical skin reaction in a 73-year-old woman with advanced non-small cell lung cancer, who developed a squamous-crusted eruption on her face after 4 weeks of oral treatment with gefitinib at a dose of 250 mg/day. The patient was treated with 100 mg minocyclin (2 tablets/day, orally) and with ryfamicin topically. A complete resolution of the lesions was observed 2 weeks later. The present case report explored the pathogenesis of this skin manifestation, focusing on the underlying immunological mechanisms. A review of the literature concerning skin reactions to gefitinib was also conducted.
authors.affiliation: Dermatology Unit, Department of Medicine, University of Padua, Padua I-35121, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Ferrazzi
authors.affiliation: Dermatology Unit, Department of Medicine, University of Padua, Padua I-35121, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Russo
authors.affiliation: Unit of Medical Oncology, Veneto Institute of Oncology IOV-IRCCS, Padua I-35128, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Pasello
authors.affiliation: Dermatology Unit, Department of Medicine, University of Padua, Padua I-35121, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Alaibac
keywords: epidermal growth factor receptor; gefitinib; skin immune system