title: Risk factors for long-term mortality of Staphylococcus aureus bacteremia.
abstract: Staphylococcus aureus bacteremia (SAB) is a fatal disease. We aimed to describe risk factors for long-term mortality with SAB. We analyzed data from a retrospectively collected database including 1,692 patients with SAB. We considered variables of infection and background conditions for the analysis of long-term survival. The Kaplan-Meier procedure was used for analysis of long-term survival. Variables significantly associated with mortality were analyzed using a Cox regression model. We included 1,692 patients in the analysis. Patients were followed for up to 22 years. Within one year, 62% of patients died and within 5 years 72% died. A total of 82% of patients aged 65 years and older died within 5 years. Independent predictors of long-term mortality were older age (Hazard ratio 1.029, 95% confidence interval 1.022-1.036), female gender (HR 1.302, 95% CI 1.118-1.517), pneumonia or primary/ unknown source of infection (HR 1.441, 95% CI 1.230-1.689), dementia (HR 1.234, 95% CI 1.004-1.516), higher Charlson score (HR 1.155, 95% CI 1.115-1.196), shock at onset (HR 1.776, 95% CI 1.430-2.207) and arrival to hospitalization from an institution (HR 1.319, 95% CI 1.095-1.563). Long-term survival of patients older than 65 years and of women with SAB is severely curtailed.
authors.affiliation: Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, 39 Jabotinsky Road, Petah-Tikva, 49100, Israel. dafna.yahav@gmail.com.|Sackler Faculty of Medicine, Tel Aviv University, Ramat-Aviv, Israel. dafna.yahav@gmail.com.
authors.forename: D
authors.initials: D
authors.lastname: Yahav
authors.affiliation: Department of Medicine D, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Yassin
authors.affiliation: Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, 39 Jabotinsky Road, Petah-Tikva, 49100, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Shaked
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Ramat-Aviv, Israel.|Department of Medicine F, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Goldberg
authors.affiliation: Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, 39 Jabotinsky Road, Petah-Tikva, 49100, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Ramat-Aviv, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Bishara
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Ramat-Aviv, Israel.|Unit of Infectious Diseases, Rambam Hospital, Haifa, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Paul
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Ramat-Aviv, Israel.|Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Leibovici
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology* / Q000401:mortality*; D013211:Staphylococcus aureus