title: Effects of Hypobaric Hypoxia in Various Modes on Expression of Neurogenesis Marker NeuroD2 in the Dentate Gyrus of Rats Hippocampus.
abstract: The expression of neurogenesis marker--NeuroD2 transcription factor--in the hippocampal dentate gyrus was studied in rats exposed to severe destructive hypoxia, a single or three episodes of moderate hypobaric hypoxia, preconditioned severe hypoxia, and severe hypoxia followed by 3 sessions of postconditioning by moderate hypobaric hypoxia. All the studied hypoxic exposure modes led to an increase of NeuroD2 level. Three-fold moderate hypoxia per se and in the preconditioning mode (followed by exposure to severe hypoxia) produced most pronounced up-regulatory effect on NeuroD2 expression. The results indicated that stimulation of neurogenesis processes seemed to be one of the aspects of the neuroprotective effect of three-fold preconditioning moderate hypoxia, but not of hypoxic postconditioning.
authors.affiliation: Laboratory of Regulation of Cerebral Neuron Functions, St. Petersburg, Russia. vov210292@yandex.ru.
authors.forename: O V
authors.initials: OV
authors.lastname: Vetrovoi
authors.affiliation: Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Rybnikova
authors.affiliation: Laboratory of Regulation of Cerebral Neuron Functions, St. Petersburg, Russia.
authors.forename: T S
authors.initials: TS
authors.lastname: Glushchenko
authors.affiliation: Laboratory of Regulation of Cerebral Neuron Functions, St. Petersburg, Russia.
authors.forename: M O
authors.initials: MO
authors.lastname: Samoilov
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D015687:Cell Hypoxia / Q000502:physiology*; D018891:Dentate Gyrus / Q000378:metabolism*; D019194:Ischemic Preconditioning; D008297:Male; D055495:Neurogenesis / Q000502:physiology; D009479:Neuropeptides / Q000378:metabolism*; D018696:Neuroprotective Agents; D051381:Rats; D017208:Rats, Wistar
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D009479:Neuropeptides; D018696:Neuroprotective Agents; C490924:Neurod2 protein, rat
keywords: NeuroD2; dentate gyrus; hypobaric hypoxia; neurogenesis