title: Continuous manufacturing of tablets with PROMIS-line - Introduction and case studies from continuous feeding, blending and tableting.
abstract: Drug manufacturing technology is in the midst of modernization and continuous manufacturing of drug products is especially the focus of great interest. The adoption of new manufacturing approaches requires extensive cooperation between industry, regulatory bodies, academics and equipment manufacturers. In this paper we introduce PROMIS-line which is a continuous tableting line built at the University of Eastern Finland, School of Pharmacy, PROMIS-centre. PROMIS-line is modular and tablets can be produced via dry granulation or direct compression. In three case studies, continuous feeding, blending and tablet performance is studied to illustrate some basic features of PROMIS-line. In conclusion, the PROMIS-line is an excellent tool for studying the fundamentals of continuous manufacturing of tablets.
authors.affiliation: University of Eastern Finland, School of Pharmacy, PROMIS-Centre, FI-70211 Kuopio, Finland.
authors.forename: Simo-Pekka
authors.initials: SP
authors.lastname: Simonaho
authors.affiliation: University of Eastern Finland, School of Pharmacy, PROMIS-Centre, FI-70211 Kuopio, Finland.
authors.forename: Jarkko
authors.initials: J
authors.lastname: Ketolainen
authors.affiliation: University of Eastern Finland, School of Pharmacy, PROMIS-Centre, FI-70211 Kuopio, Finland.
authors.forename: Tuomas
authors.initials: T
authors.lastname: Ervasti
authors.affiliation: VTT Technical Research Center of Finland, Photon Devices & Measurement Solutions, P.O. Box 1199, FI-70211 Kuopio, Finland.
authors.forename: Maunu
authors.initials: M
authors.lastname: Toiviainen
authors.affiliation: University of Eastern Finland, School of Pharmacy, PROMIS-Centre, FI-70211 Kuopio, Finland. Electronic address: ossi.korhonen@uef.fi.
authors.forename: Ossi
authors.initials: O
authors.lastname: Korhonen
mesh_terms: D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods; D004345:Drug Industry / Q000295:instrumentation* / Q000379:methods*; D011208:Powders / Q000737:chemistry; D013607:Tablets / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000295:instrumentation* / Q000379:methods*
chemical_list: D011208:Powders; D013607:Tablets
keywords: Blending; Continuous manufacturing; Feeding; Tableting