title: Alteration of Duration Mismatch Negativity Induced by Transcranial Magnetic Stimulation Over the Left Parietal Lobe.
abstract: Mismatch negativity (MMN) is generated by a comparison between an incoming sound and the memory trace of preceding sounds stored in sensory memory without any attention to the sound. N100 (N1) is associated with the afferent response to sound onset and reflects early analysis of stimulus characteristics. MMN generators are present in the temporal and frontal lobe, and N1 generators are present in the temporal lobe. The parietal lobe is involved in MMN generation elicited by a change in duration. The anatomical network connecting these areas, lateralization, and the effect of the side of ear stimulation on MMN remain unknown. Thus, we studied the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) over the left parietal lobe on MMN and N1 in 10 healthy subjects. Low-frequency rTMS over the left parietal lobe decreased the amplitude of MMN following right ear sound stimulation, but the amplitude was unaffected with left ear sound stimulation. We observed no significant changes in the amplitude of N1 or the latency of MMN or N1. These results suggest that low-frequency rTMS over the left parietal lobe modulates the detection of early auditory changes in duration in healthy subjects. Stimulation that is contralateral to the side of the ear experiencing sound may affect the generation of duration MMN more than ipsilateral stimulation.
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan hirokazu@fmu.ac.jp.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Oshima
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shiga
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
authors.forename: Shin-Ichi
authors.initials: SI
authors.lastname: Niwa
authors.affiliation: Department of Neurology, Fukushima Medical University, Fukushima, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Enomoto
authors.affiliation: Department of Neurology, Fukushima Medical University, Fukushima, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ugawa
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
authors.forename: Hirooki
authors.initials: H
authors.lastname: Yabe
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
keywords: event-related potential (ERP); mismatch negativity (MMN); transcranial magnetic stimulation (TMS)