title: A review on ethnobotany, pharmacology and phytochemistry of Tabernaemontana corymbosa.
abstract: OBJECTIVE
  Tabernaemontana is a genus from the plant family, Apocynaceae with vast medicinal application and widespread distribution in the tropics and subtropics of Africa, Americas and Asia. The objective of this study is to critically evaluate the ethnobotany, medicinal uses, pharmacology and phytochemistry of the species, Tabernaemontana corymbosa (Roxb. ex Wall.) and provide information on the potential future application of alkaloids isolated from different parts of the plant.
  
  
  RESULTS
  T. corymbosa (Roxb. ex Wall.) parts are used as poultice, boiled juice, decoctions and infusions for treatment against ulceration, fracture, post-natal recovery, syphilis, fever, tumours and orchitis in Malaysia, China, Thailand and Bangladesh. Studies recorded alkaloids as the predominant phytochemicals in addition to phenols, saponins and sterols with vast bioactivities such as antimicrobial, analgesic, anthelmintic, vasorelaxation, antiviral and cytotoxicity.
  
  
  CONCLUSIONS
  An evaluation of scientific data and traditional medicine revealed the medicinal uses of different parts of T. corymbosa (Roxb. ex Wall.) across Asia. Future studies exploring the structure-bioactivity relationship of alkaloids such as jerantinine and vincamajicine among others could potentially improve the future application towards reversing anticancer drug resistance.
authors.affiliation: School of Biosciences, Faculty of Science, The University of Nottingham Malaysia Campus, Semenyih, Selangor, Malaysia.
authors.forename: Ibrahim Babangida
authors.initials: IB
authors.lastname: Abubakar
authors.affiliation: School of Biosciences, Faculty of Science, The University of Nottingham Malaysia Campus, Semenyih, Selangor, Malaysia.|Biotechnology Research Centre, The University of Nottingham Malaysia Campus, Semenyih, Selangor, Malaysia.
authors.forename: Hwei-San
authors.initials: HS
authors.lastname: Loh
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D019448:Ethnobotany; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D064209:Phytochemicals / Q000302:isolation & purification / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D030014:Tabernaemontana / Q000737:chemistry*; D014750:Vincristine / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D064209:Phytochemicals; D010936:Plant Extracts; D014750:Vincristine
keywords: T. corymbosa; alkaloids; anticancer; ethnomedicine; phytochemistry