title: Correlation between PON1 gene polymorphisms and breast cancer risk: a Meta-analysis.
abstract: OBJECTIVE
  A number of studies have investigated the relationship between the PON1 gene polymorphisms and breast cancer risk, but the conclusions are not consistent. In this paper, a meta-analysis was conducted to explore the possible reasons for these inconsistencies, expecting to further clarify the correlation between PON1 gene polymorphisms and breast cancer risk.
  
  
  METHODS
  After searches in the database such as MEDLINE, EBSCO, ProQuest, Google Scholar, High-Wire, SID (Scientific Information Database) and PubMed, 7 literatures were collected. RevMan 5.2 software was used to perform the meta-analysis. Random-effects or fixed-effects model was used to analyze the odds ratio (OR) and 95% confidence intervals.
  
  
  RESULTS
  The analysis of L55M single nucleotide polymorphisms (SNPs) showed that M allele frequency was positively correlated with the incidence risk of breast cancer (OR=1.34, 95% CI: 1.03-1.74). While we did not found Q192R polymorphism associated with the risk of breast cancer (OR=1.0, 95% CI: 0.71-1.42).
  
  
  CONCLUSIONS
  For PON1 gene, the frequencies of M allele were associated with the incidence risk of breast cancer.
authors.affiliation: Department of General Surgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University Chongqing 400042, P. R. China.
authors.forename: Yayuan
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Chinese Astronaut Research and Training Center Beijing 100094, P. R. China.
authors.forename: Zemin
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of General Surgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University Chongqing 400042, P. R. China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University Chongqing 400042, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Gao
authors.affiliation: Department of General Surgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University Chongqing 400042, P. R. China.
authors.forename: Yujun
authors.initials: Y
authors.lastname: He
keywords: Paraoxonase; genetics; meta-analysis