title: Skull Optical Clearing Solution for Enhancing Ultrasonic and Photoacoustic Imaging.
abstract: The performance of photoacoustic microscopy (PAM) degrades due to the turbidity of the skull that introduces attenuation and distortion of both laser and stimulated ultrasound. In this manuscript, we demonstrated that a newly developed skull optical clearing solution (SOCS) could enhance not only the transmittance of light, but also that of ultrasound in the skull in vitro. Thus the photoacoustic signal was effectively elevated, and the relative strength of the artifacts induced by the skull could be suppressed. Furthermore in vivo studies demonstrated that SOCS could drastically enhance the performance of photoacoustic microscopy for cerebral microvasculature imaging.
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Yang
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Kai
authors.initials: K
authors.lastname: Zhao
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Gong
authors.forename: Qingming
authors.initials: Q
authors.lastname: Luo
authors.forename: Dan
authors.initials: D
authors.lastname: Zhu
mesh_terms: D008853:Microscopy; D061088:Photoacoustic Techniques; D012886:Skull; D013057:Spectrum Analysis; D014463:Ultrasonography