title: Diastereoselective Ugi reaction of chiral 1,3-aminoalcohols derived from an organocatalytic Mannich reaction.
abstract: Enantiomerically pure β-aminoalcohols, produced through an organocatalytic Mannich reaction, were subjected to an Ugi multicomponent reaction under classical or Lewis acid-promoted conditions with diastereoselectivities ranging from moderate to good. This approach represents a step-economical path to enantiomerically pure, polyfunctionalized peptidomimetics endowed with three stereogenic centers, allowing the introduction of five diversity inputs.
authors.affiliation: Department of Chemistry and Industrial Chemistry, University of Genova, I-16146 Genova, Italy.
authors.forename: Samantha
authors.initials: S
authors.lastname: Caputo
authors.affiliation: Department of Chemistry and Industrial Chemistry, University of Genova, I-16146 Genova, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Basso
authors.affiliation: Department of Chemistry and Industrial Chemistry, University of Genova, I-16146 Genova, Italy.
authors.forename: Lisa
authors.initials: L
authors.lastname: Moni
authors.affiliation: Department of Chemistry and Industrial Chemistry, University of Genova, I-16146 Genova, Italy.
authors.forename: Renata
authors.initials: R
authors.lastname: Riva
authors.affiliation: Department of Chemistry and Industrial Chemistry, University of Genova, I-16146 Genova, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Rocca
authors.affiliation: Department of Chemistry and Industrial Chemistry, University of Genova, I-16146 Genova, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Banfi
keywords: Ugi reaction; aminoalcohols; isocyanides; multicomponent reactions; peptidomimetics