title: A LRSAM1 mutation links Charcot-Marie-Tooth type 2 to Parkinson's disease.
abstract: LRSAM1 mutations have been found in recessive and dominant forms of Charcot-Marie-Tooth disease. Within one generation of the original Dutch family in which the dominant LRSAM1 mutation was identified, three of the five affected family members have developed Parkinson's disease between ages 50 and 65 years, many years after neuropathy onset. We speculate that this late-onset parkinsonism is part of the LRSAM1 phenotype, thus associating a hitherto peripheral nerve disease with a central nervous system phenotype. How the mutated Lrsam1 protein, which normally has E3 ubiquitin ligase activity and is expressed in the nervous system, impacts on substantia nigra neurons is unclear.
authors.affiliation: Department of Neurology Donders Institute for Brain, Cognition, and Behaviour Radboud University Medical Center Nijmegen The Netherlands.
authors.forename: Marjolein B
authors.initials: MB
authors.lastname: Aerts
authors.affiliation: Department of Genome Analysis Academic Medical Center Amsterdam The Netherlands.
authors.forename: Marian A J
authors.initials: MA
authors.lastname: Weterman
authors.affiliation: Department of Clinical Genetics Erasmus MC Rotterdam The Netherlands.
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Quadri
authors.affiliation: Epilepsy Centre Kempenhaeghe Heeze The Netherlands.
authors.forename: H Jurgen
authors.initials: HJ
authors.lastname: Schelhaas
authors.affiliation: Department of Neurology Donders Institute for Brain, Cognition, and Behaviour Radboud University Medical Center Nijmegen The Netherlands.
authors.forename: Bastiaan R
authors.initials: BR
authors.lastname: Bloem
authors.affiliation: Department of Neurology Donders Institute for Brain, Cognition, and Behaviour Radboud University Medical Center Nijmegen The Netherlands.
authors.forename: Rianne A
authors.initials: RA
authors.lastname: Esselink
authors.affiliation: Department of Genome Analysis Academic Medical Center Amsterdam The Netherlands.
authors.forename: Frank
authors.initials: F
authors.lastname: Baas
authors.affiliation: Department of Clinical Genetics Erasmus MC Rotterdam The Netherlands.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Bonifati
authors.affiliation: Department of Neurology Donders Institute for Brain, Cognition, and Behaviour Radboud University Medical Center Nijmegen The Netherlands.
authors.forename: Bart P
authors.initials: BP
authors.lastname: van de Warrenburg