title: [Ocular syndromes in patients with neurobrucellosis].
abstract: OBJECTIVE
  To investigate the clinical features of ocular syndromes in patients with neurobrucellosis.
  
  
  METHODS
  This is a retrospective series case study. The clinical data of 5 patients with neurobrucellosis, who were treated in Department of Neurology, Beijing Tongren Hospital, Captical Medical Uinversity, from May 2009 to January 2015, were collected. Their epidemiological information, clinical manifestation, laboratory and radiologic examination, therapy and prognosis were analyzed.
  
  
  RESULTS
  Among the five patients, there were 3 males and 2 females, and their ages ranged from 20 to 67 years. The median age was 25 years. All patients had ever exposed to sheep. 1 patient lived close to a slaughterhouse and 2 patients lived in epidemic areas of brucellosis. 5 patients presented with binocular vision loss, 8 eyes with fundus edema, 3 patients with ophthalmoplegia;4 patients with fever,4 patients with headache,3 patients with neck stiffness,1 patient with movement and sensation disorders. Cerebrospinal fluid (CSF) pressure elevated, white cell number and protein increased with glucose reduction were detected respectively in 3 cases. While, CSF chloride decreased in 2 cases. Serum agglutination test for brucella was positive in 5 patients. Serum brucella culture was positive in 1 patient and CSF brucella culture was positive in 1 patient. Brain magnetic resonance imaging (MRI) showed that the optic nerve was involved in 3 patients,the meninges were involved in 1 patient and the brain white matter was involved in 1 patient. The combination of rifamycin, tetracycline, ceftriaxone sodium or quinolone were given to all patients and showed appreciated effects.
  
  
  CONCLUSIONS
  The clinical features of ocular syndromes are atypical in patients with neurobrucellosis. Vision loss and ophthalmoplegia are more common to be seen. Neurobrucellosis should be considered when patients with ocular signs and other system symptoms without a definite diagnosis.
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Qingchen
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Dai
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Email: yun_jing@yahoo.com.
authors.forename: Yun
authors.initials: Y
authors.lastname: Jing
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002006:Brucellosis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D020806:Central Nervous System Bacterial Infections / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D015818:Eye Infections, Bacterial / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012294:Rifamycins; D012756:Sheep; D013577:Syndrome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D012294:Rifamycins; C023808:rifamycin SV