title: Getting lost: Topographic skills in acquired and developmental prosopagnosia.
abstract: Previous studies report that acquired prosopagnosia is frequently associated with topographic disorientation. Whether this is associated with a specific anatomic subtype of prosopagnosia, how frequently it is seen with the developmental variant, and what specific topographic function is impaired to account for this problem are not known. We studied ten subjects with acquired prosopagnosia from either occipitotemporal or anterior temporal (AT) lesions and seven with developmental prosopagnosia. Subjects were given a battery of topographic tests, including house and scene recognition, the road map test, a test of cognitive map formation, and a standardized self-report questionnaire. House and/or scene recognition were frequently impaired after either occipitotemporal or AT lesions in acquired prosopagnosia. Subjects with occipitotemporal lesions were also impaired in cognitive map formation: an overlap analysis identified right fusiform and parahippocampal gyri as a likely correlate. Only one subject with acquired prosopagnosia had mild difficulty with directional orientation on the road map test. Only one subject with developmental prosopagnosia had difficulty with cognitive map formation, and none were impaired on the other tests. Scores for house and scene recognition correlated most strongly with the results of the questionnaire. We conclude that topographic disorientation in acquired prosopagnosia reflects impaired place recognition, with a contribution from poor cognitive map formation when there is occipitotemporal damage. Topographic impairments are less frequent in developmental prosopagnosia.
authors.affiliation: Human Vision and Eye Movement Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Science, University of British Columbia, Vancouver, Canada.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Corrow
authors.affiliation: Human Vision and Eye Movement Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Science, University of British Columbia, Vancouver, Canada.
authors.forename: Sherryse L
authors.initials: SL
authors.lastname: Corrow
authors.affiliation: Human Vision and Eye Movement Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Science, University of British Columbia, Vancouver, Canada.|College of Osteopathic Medicine, University of New England, Biddeford USA.
authors.forename: Edison
authors.initials: E
authors.lastname: Lee
authors.affiliation: Human Vision and Eye Movement Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Science, University of British Columbia, Vancouver, Canada.
authors.forename: Raika
authors.initials: R
authors.lastname: Pancaroglu
authors.affiliation: NeuroLab, Department of Psychology, Hotchkiss Brain Institute, and Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.
authors.forename: Ford
authors.initials: F
authors.lastname: Burles
authors.affiliation: Department of Psychology, Dartmouth University, Dartmouth USA.
authors.forename: Brad
authors.initials: B
authors.lastname: Duchaine
authors.affiliation: NeuroLab, Department of Psychology, Hotchkiss Brain Institute, and Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Iaria
authors.affiliation: Human Vision and Eye Movement Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Science, University of British Columbia, Vancouver, Canada.
authors.forename: Jason J S
authors.initials: JJS
authors.lastname: Barton
mesh_terms: D000328:Adult; D000368:Aged; D004192:Discrimination, Psychological; D005145:Face / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology / Q000503:physiopathology*; D009949:Orientation / Q000502:physiology*; D020238:Prosopagnosia / Q000503:physiopathology*; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology*; D055815:Young Adult
keywords: Face recognition; Landmark; Navigation; Orientation; Places