title: Parvovirus infection in early arthritis.
abstract: OBJECTIVE
  To analyse the subgroup of early arthritis patients with new onset parvovirus infections for details that may help narrow the population tested.
  
  
  METHODS
  From their routine patient charts, patient histories and clinical and serological data were obtained for all 130 patients of the Rheumatology division with parvovirus serology performed. 11 patients had acute parvovirus infections, defined by specific IgM antibodies. 95 patients had a previous infection, 16 were never infected, together forming the n=111 control group, and 8 patients had to be excluded.
  
  
  RESULTS
  Most patients with acute parvovirus infection had an acute onset, highly symmetrical polyarthritis of small joints, which was preceded by prodromal symptoms. Positive ANA were frequently found, whereas C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were only mildly elevated. No frank synovitis was found longer than two weeks after disease onset. Most patients were free of symptoms within three months, and no patient in the parvovirus group developed rheumatoid arthritis or a connective tissue disease.
  
  
  CONCLUSIONS
  Parvovirus serology may be helpful in patients with acute polyarthritis of very recent onset, and if they give a history of prodromal symptoms, in particular. In most instances, parvovirus arthritis is an acute disease, which is rapidly self-limiting.
authors.affiliation: Division of Rheumatology, Department of Medicine III, University Medical Center and Faculty of Medicine Carl Gustav Carus at the TU Dresden, Dresden, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Mauermann
authors.affiliation: Institute of Virology, Faculty of Medicine Carl Gustav Carus at the TU Dresden, Dresden, Germany.
authors.forename: Kristina
authors.initials: K
authors.lastname: Hochauf-Stange
authors.affiliation: Division of Rheumatology, Department of Medicine III, University Medical Center and Faculty of Medicine Carl Gustav Carus at the TU Dresden, Dresden, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kleymann
authors.affiliation: Institute of Immunology, Faculty of Medicine Carl Gustav Carus at the TU Dresden, Dresden, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Conrad
authors.affiliation: Division of Rheumatology, Department of Medicine III, University Medical Center and Faculty of Medicine Carl Gustav Carus at the TU Dresden, Dresden, Germany. martin.aringer@uniklinikum-dresden.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Aringer
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000150:complications*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M