title: [Correlation Study on Chinese Medical Syndrome Types of Chronic Atrophic Gastritis Patients, Hp, and IL-1β Polymorphism].
abstract: OBJECTIVE
  To explore the correlation between Chinese medical (CM) syndrome types of chronic atrophic gastritis (CAG) patients and Helicobacter pylori (Hp) infection, polymorphisms of IL-1B, and IL-1β.
  
  
  METHODS
  Totally 192 CAG patients and 202 healthy subjects (as the healthy control group) were recruited in this case-control study. The Hp infection was tested by 13C-urea breath test and colloidal gold-labeled assay (GICA). The concentration of peripheral blood IL-1β was measured by ELISA. The polymorphisms of IL-1B gene in the promoter region were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  Pi-Wei weakness syndrome (PWWS) was dominant in CAG patients (31.77%, 61/192 cases). The Hp infection ratio in CAG patients was 53.65% (103/192 cases), of which, Pi-Wei damp-heat syndrome(PWDHS, 64.86%, 24/37 cases) and Gan-Wei disharmony syndrome (GWDS, 66.67%, 24/36 cases) were dominant. Compared with the health control group, the plasma concentration of IL-1β was obviously elevated in CAG patients with PWDHS, GWDS, and static blood obstructing collaterals syndrome (SBOCS) (all P < 0.05). Additionally, there was no difference in the distribution of polymorphisms in the promoter region of IL-1 B gene between the CAG patients and the healthy control group (P > 0.05).
  
  
  CONCLUSIONS
  The incidence risk of CAG was not associated with IL-1B polymorphism. But CM syndrome types of CAG patients was associated with Hp infection and peripheral blood IL-1β levels.
authors.forename: Jian-zhi
authors.initials: JZ
authors.lastname: Zhang
authors.forename: Quan-lin
authors.initials: QL
authors.lastname: Feng
authors.forename: Yi-lu
authors.initials: YL
authors.lastname: Hu
authors.forename: Ti
authors.initials: T
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D005756:Gastritis; D005757:Gastritis, Atrophic / Q000235:genetics*; D016481:Helicobacter Infections / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D015994:Incidence; D053583:Interleukin-1beta / Q000235:genetics*; D008516:Medicine, Chinese Traditional; D011110:Polymorphism, Genetic
chemical_list: D053583:Interleukin-1beta