title: Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases.
abstract: Oxidative stress results from a disturbed balance between oxidation and antioxidant systems. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) may be either harmful or beneficial to the cells. Ion channels are transmembrane proteins that participate in a large variety of cellular functions and have been implicated in the development of a variety of diseases. A significant amount of the available drugs in the market targets ion channels. These proteins have sulfhydryl groups of cysteine and methionine residues in their structure that can be targeted by ROS and RNS altering channel function including gating and conducting properties, as well as the corresponding signaling pathways associated. The regulation of ion channels by ROS has been suggested to be associated with some pathological conditions including liver diseases. This review focuses on understanding the role and the potential association of ion channels and oxidative stress in liver diseases including fibrosis, alcoholic liver disease, and cancer. The potential association between ion channels and oxidative stress conditions could be used to develop new treatments for major liver diseases.
authors.affiliation: Department of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, 07360 Mexico City, DF, Mexico.
authors.forename: Ana
authors.initials: A
authors.lastname: Ramírez
authors.affiliation: Department of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, 07360 Mexico City, DF, Mexico.
authors.forename: Alma Yolanda
authors.initials: AY
authors.lastname: Vázquez-Sánchez
authors.affiliation: Department of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, 07360 Mexico City, DF, Mexico; Departamento de Ciencias de la Vida, Universidad de las Fuerzas Armadas, ESPE, Avenida General Rumiñahui, 171-5-231-B Sangolquí, Ecuador.
authors.forename: Natalia
authors.initials: N
authors.lastname: Carrión-Robalino
authors.affiliation: Department of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, 07360 Mexico City, DF, Mexico.
authors.forename: Javier
authors.initials: J
authors.lastname: Camacho
mesh_terms: D000437:Alcoholism / Q000150:complications; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D018118:Chloride Channels / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects; D006526:Hepatitis C / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism*; D008108:Liver Diseases, Alcoholic / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D011983:Receptors, Purinergic / Q000378:metabolism; D015398:Signal Transduction; D050053:TRPM Cation Channels / Q000378:metabolism; D050916:TRPV Cation Channels / Q000378:metabolism
chemical_list: D000975:Antioxidants; D018118:Chloride Channels; D007473:Ion Channels; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D011983:Receptors, Purinergic; D050053:TRPM Cation Channels; D050916:TRPV Cation Channels; C416986:TRPV4 protein, human; D000431:Ethanol; D017346:Protein Serine-Threonine Kinases; C486583:TRPM7 protein, human