title: LPL gene mutation as the cause of severe hypertriglyceridemia in the course of ketoacidosis in a patient with newly diagnosed type 1 diabetes mellitus.
abstract: BACKGROUND
  Severe hypertriglyceridemia is a condition associated with extremely high triglycerides (TG) plasma concentrations exceeding 1000mg/dl. This condition may result in mutations in genes encoding lipoprotein lipase (LPL), apolipoprotein C2 (APOC2) and apolipoprotein A5 (APOA5) characterized by an autosomal recessive inheritance pattern.
  
  
  OBJECTIVE
  A case report of a patient in which clinical picture of type 1 diabetes mellitus (T1DM) was accompanied by diabetic ketoacidosis (DKA) and severe hypertriglyceridemia.
  
  
  METHODS
  A 2.5-year-old boy was admitted to the hospital with ketoacidosis (pH - 7.0, BE - 20mmol/l, HCO3 10mmol/l), glucose level of 850mg%, hyponatremia (Na 100mmol/l) and hyperlipidemia (TG 13493 mg/dl, TC 734 mg/dl). The administered treatment resulted in nearly normal glycemic values and lipid disturbances normalization. This child was diagnosed with a heterozygous mutation of the LPL gene. Currently with an intensive insulin therapy and correct metabolic control of type 1 diabetes mellitus (T1DM), this patient maintains a normal lipid profile.
  
  
  CONCLUSIONS
  In patient with T1DM the diagnosis of severe hypertriglyceridemia in the course of ketoacidosis should be based on careful interpretation of laboratory tests results. Moreover genetic tests of the patient and his/her immediate relatives blood samples should be performed.
authors.affiliation: Department of Endocrinology and Diabetology for Children and Adolescents, Wroclaw Medical University.
authors.forename: Julita
authors.initials: J
authors.lastname: Nocoń-Bohusz
authors.affiliation: Department of Endocrinology and Diabetology for Children and Adolescents, Wroclaw Medical University.
authors.forename: Beata
authors.initials: B
authors.lastname: Wikiera
authors.affiliation: Department of Endocrinology and Diabetology for Children and Adolescents, Wroclaw Medical University.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Basiak
authors.affiliation: Department of Genetics, Wroclaw Medical University.
authors.forename: Robert
authors.initials: R
authors.lastname: Śmigiel
authors.affiliation: Department of Endocrinology and Diabetology for Children and Adolescents, Wroclaw Medical University.
authors.forename: Anna
authors.initials: A
authors.lastname: Noczyńska
mesh_terms: D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy / Q000235:genetics*; D016883:Diabetic Ketoacidosis / Q000150:complications* / Q000188:drug therapy / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D009154:Mutation; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents; D008071:Lipoprotein Lipase