title: Association between DCHS2 gene and mild cognitive impairment and Alzheimer's disease in an elderly Brazilian sample.
abstract: In 2012, Kamboh and colleagues published a genome-wide association study that identified the DCHS2 gene (rs1466662 T/A) influencing the age at onset of Alzheimer's disease (AD). We aimed to investigate if there is association between the DCHS2 gene and amnestic mild cognitive impairment (aMCI) and AD in a sample of the Brazilian population.
  
  
  
  143 controls, 79 aMCI and 299 AD patients were selected and submitted to the same protocol of tests. Genotyping was performed using the Real Time PCR RESULTS: Amnestic MCI patients showed a higher prevalence of AA than controls and a lower frequency of TT when compared with controls. We also stratified the sample according to the APOE ε4 status. No difference in DCHS2 genotype or allelic frequency occurred in the APOE ε4 allele carrier subgroup. Amnestic MCI patients showed a higher frequency of AA genotype and a lower frequency of TA and TT when compared with controls in APOE ε4 allele non-carrier subgroup. The allelic distribution followed the same pattern. In AD group, we observed a significant difference with a higher A allelic frequency in AD in this subgroup. A multiple logistic regression demonstrated that in APOE ε4 non-carriers, allele rs1466662 was associated to aMCI group. Different variables were associated with aMCI and AD according to APOE ε4 status in our sample. Low level of education was associated with AD, while diabetes mellitus type 2 was associated with aMCI. Copyright © 2016 John Wiley & Sons, Ltd.
  
  
  
  Our findings suggest a possible role for DCHS2 gene in aMCI and AD.
authors.affiliation: INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Renalice Neves
authors.initials: RN
authors.lastname: Vieira
authors.affiliation: INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.|Reference Center for Geriatrics Instituto Jenny de Andrade Faria de Atenção à Saúde do Idoso, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Rafaela
authors.initials: R
authors.lastname: Ávila
authors.affiliation: INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.|Reference Center for Geriatrics Instituto Jenny de Andrade Faria de Atenção à Saúde do Idoso, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Jonas Jardim
authors.initials: JJ
authors.lastname: de Paula
authors.affiliation: Reference Center for Geriatrics Instituto Jenny de Andrade Faria de Atenção à Saúde do Idoso, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Marco Túlio Gualberto
authors.initials: MT
authors.lastname: Cintra
authors.affiliation: INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Renan Pedra
authors.initials: RP
authors.lastname: de Souza
authors.affiliation: INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.|Department of Mental Health, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Nicolato
authors.affiliation: INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.|Reference Center for Geriatrics Instituto Jenny de Andrade Faria de Atenção à Saúde do Idoso, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Leandro
authors.initials: L
authors.lastname: Malloy-Diniz
authors.affiliation: INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.|Department of Pediatrics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Débora Marques
authors.initials: DM
authors.lastname: de Miranda
authors.affiliation: INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.|Reference Center for Geriatrics Instituto Jenny de Andrade Faria de Atenção à Saúde do Idoso, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.|Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Edgar Nunes
authors.initials: EN
authors.lastname: de Moraes
authors.affiliation: INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.|Department of Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Luiz Armando
authors.initials: LA
authors.lastname: de Marco
authors.affiliation: INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.|Department of Mental Health, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Marco Aurélio
authors.initials: MA
authors.lastname: Romano-Silva
authors.affiliation: INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. macbicalho@gmail.com.|Reference Center for Geriatrics Instituto Jenny de Andrade Faria de Atenção à Saúde do Idoso, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. macbicalho@gmail.com.|Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. macbicalho@gmail.com.
authors.forename: Maria Aparecida Camargos
authors.initials: MA
authors.lastname: Bicalho
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D001938:Brazil / Q000453:epidemiology; D015820:Cadherins / Q000235:genetics*; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000235:genetics*; D004522:Educational Status; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D012307:Risk Factors
chemical_list: D015820:Cadherins
keywords: Alzheimer's disease; DCHS2; mild cognitive impairment; rs1466662