title: Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation.
abstract: Efficient protocols enabling the rapid installation of trifluoromethyl, as well as further functionalized fluoroalkyl groups by an electrophilic perfluoroalkylation of lactam-derived ketene silyl amides (KSAs) using hypervalent iodine reagents 1 and 2 have been developed.
authors.affiliation: Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland. atogni@ethz.ch.
authors.forename: D
authors.initials: D
authors.lastname: Katayev
authors.affiliation: Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland. atogni@ethz.ch and Institute of Organic Chemistry and Biochemistry, v.v.i. Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Václavík
authors.affiliation: Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland. atogni@ethz.ch.
authors.forename: F
authors.initials: F
authors.lastname: Brüning
authors.affiliation: Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland. atogni@ethz.ch.
authors.forename: B
authors.initials: B
authors.lastname: Commare
authors.affiliation: Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland. atogni@ethz.ch.
authors.forename: A
authors.initials: A
authors.lastname: Togni
mesh_terms: D002384:Catalysis; D005030:Ethylenes / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D005030:Ethylenes; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D007659:Ketones; D007769:Lactams; D007455:Iodine; C008223:ketene