title: Two Case Reports of Nodular Fasciitis: A Newly Recognized Placental Lesion.
abstract: We describe two occurrences of nontrophoblastic mesenchymal tumors of the placenta. The first placental tumor was found along the placental margin, and the second was identified close to the insertion of the fetal membranes along the placental disc. Microscopically both lesions demonstrated bland fibroblastic cells with intricate vasculature and inflammatory cells. Both lesions were negative for estrogen receptor (ER), progesterone receptor (PR), beta-HCG, PLAP, CD34, desmin, h-caldesmin, and smooth muscle actin by immunohistochemistry. Some cells were weakly positive for CD10, a nonspecific finding. The morphologic and immunohistochemical characteristics of these lesions were most consistent with nodular fasciitis, a tumor most commonly found in the soft tissues. FISH positive for USP6 gene rearrangement in our two patients confirmed the molecular similarity of these lesions to nodular fasciitis of soft tissue. Such lesions can be easily dismissed on gross placental examination as infarcts or thrombi, thus these rare entities are likely underreported.
authors.affiliation: a Department of Pathology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: Brian C
authors.initials: BC
authors.lastname: Willis
authors.affiliation: a Department of Pathology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: Sydney R
authors.initials: SR
authors.lastname: Archer
authors.affiliation: a Department of Pathology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: Rida
authors.initials: R
authors.lastname: Shahid
authors.affiliation: a Department of Pathology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: Nasim
authors.initials: N
authors.lastname: Khoshnam
authors.affiliation: a Department of Pathology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: Julia
authors.initials: J
authors.lastname: Shinnick
authors.affiliation: a Department of Pathology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: L H
authors.initials: LH
authors.lastname: Lou
authors.affiliation: a Department of Pathology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Hearn
authors.affiliation: a Department of Pathology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Ilse
authors.affiliation: a Department of Pathology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Rizk
authors.affiliation: a Department of Pathology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Thompson
authors.affiliation: b University of South Florida School of Medicine , Tampa , Florida , USA.
authors.forename: Enid
authors.initials: E
authors.lastname: Gilbert-Barness
authors.affiliation: a Department of Pathology , Emory University School of Medicine , Atlanta , Georgia , USA.
authors.forename: Bahig M
authors.initials: BM
authors.lastname: Shehata
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: FISH; nodular fasciitis; placental tumor