title: Calcium phosphate nanocoatings and nanocomposites, part 2: thin films for slow drug delivery and osteomyelitis.
abstract: During the last two decades although many calcium phosphate based nanomaterials have been proposed for both drug delivery, and bone regeneration, their coating applications have been somehow slow due to the problems related to their complicated synthesis methods. In order to control the efficiency of local drug delivery of a biomaterial the critical pore sizes as well as good control of the chemical composition is pertinent. A variety of calcium phosphate based nanocoated composite drug delivery systems are currently being investigated. This review aims to give an update into the advancements of calcium phosphate nanocoatings and thin film nanolaminates. In particular recent research on PLA/hydroxyapatite composite thin films and coatings into the slow drug delivery for the possible treatment of osteomyelitis is covered.
authors.affiliation: Faculty of Science, University of Technology Sydney, 15 Broadway, Ultimo NSW 2007, Australia.
authors.forename: Besim
authors.initials: B
authors.lastname: Ben-Nissan
authors.affiliation: Faculty of Science, University of Technology Sydney, 15 Broadway, Ultimo NSW 2007, Australia.
authors.forename: Innocent
authors.initials: I
authors.lastname: Macha
authors.affiliation: Université de Toulouse, CIRIMAT, UMR 5085 UPS-INPT-CNRS, faculté de pharmacie, Toulouse, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Cazalbou
authors.affiliation: Faculty of Science, University of Technology Sydney, 15 Broadway, Ultimo NSW 2007, Australia.
authors.forename: Andy H
authors.initials: AH
authors.lastname: Choi
mesh_terms: D001861:Bone Regeneration / Q000187:drug effects*; D002130:Calcium Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems; D017886:Durapatite / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use*; D010019:Osteomyelitis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D017886:Durapatite; C020243:calcium phosphate
keywords: antibiotics; biofilm; drug delivery; hydroxyapatite; nanocoatings; nanocomposites; nanolaminates; osteomyelitis; thin films