title: Cell cycle aberration in ameloblastoma and adenomatoid odontogenic tumor: As evidenced by the expression of p53 and survivin.
abstract: BACKGROUND
  p53 and survivin are involved in cell cycle progression and inhibition of apoptosis, respectively. Survivin is a unique protein which functions in progression of cell division and inhibits apoptosis leading to cell proliferation and cell survival. According to the literature, mutation of p53 leads to promotion of survivin function. Thus, the importance of cell cycle aberration and uncontrolled proliferation resulting from mutation of p53 and up-regulation of survivin is discussed.
  
  
  OBJECTIVE
  To assess the role of p53 and survivin in ameloblastoma and adenomatoid odontogenic tumor (AOT).
  
  
  METHODS
  The percentages of positive tumor cells were considered for statistical evaluation. Nuclear labeling index for p53 and nuclear, cytoplasmic and combined labeling index for survivin was obtained from the stained slides.
  
  
  METHODS
  Immunohistochemical expression of p53 and survivin was done qualitatively and quantitatively in 25 cases each of ameloblastoma and AOT.
  
  
  METHODS
  Mann-Whitney U-test, Wilcoxon signed ranks test and Pearson's correlation test.
  
  
  RESULTS
  Quantitatively, p53 and survivin expression was statistically significant in AOT (P = 0.003) and qualitatively, in ameloblastoma (P = 0.004). Survivin expression was significant (P = 0.002) between the study groups unlike that of p53 (P = 0.554).
  
  
  CONCLUSIONS
  There was no much difference in p53 expression in ameloblastoma and AOT suggestive of cell cycle aberration in both the odontogenic tumors, but significant difference in survivin expression in ameloblastoma and AOT with higher percentage of positive cells in ameloblastoma may be indicative of an aggressive behavior of ameloblastoma.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Al-Badar Dental College and Hospital, Gulbarga, Karnataka, India.
authors.forename: Zulfin
authors.initials: Z
authors.lastname: Shaikh
authors.forename: K C
authors.initials: KC
authors.lastname: Niranjan
mesh_terms: D000564:Ameloblastoma / Q000378:metabolism*; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002453:Cell Cycle; D049109:Cell Proliferation; D002470:Cell Survival; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D009808:Odontogenic Tumors / Q000378:metabolism*; D012189:Retrospective Studies; D000077022:Survivin; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin; D016159:Tumor Suppressor Protein p53