title: Anti-norovirus therapeutics: a patent review (2010-2015).
abstract: BACKGROUND
  Human noroviruses are the primary causative agents of acute gastroenteritis and are a pressing public health burden worldwide. There are currently no vaccines or small molecule therapeutics available for the treatment or prophylaxis of norovirus infections. An improved understanding of norovirus biology, as well as the pathogenic mechanisms underlying the disease, has provided the impetus for a range of intense exploratory drug discovery efforts targeting viral and host factors.
  
  
  METHODS
  An overview of norovirus inhibitors disclosed in the patent literature (2010-present) and Clinicaltrials.gov is presented. The review is further enriched and supplemented by recent literature reports.
  
  
  CONCLUSIONS
  Seminal discoveries made in recent years, including a better understanding of the pathobiology and life cycle of norovirus, the identification and targeting of multiple viral and host factors, the advent of a replicon system and a small animal model for the preclinical evaluation of lead compounds, and the availability of high resolution X-ray crystal structures that can be utilized in structure-based drug design and lead optimization campaigns, collectively suggest that a small molecule therapeutic and prophylactic for norovirus infection is likely to emerge in the not too distant future.
authors.affiliation: a Department of Chemistry , Wichita State University , Wichita , KS , USA.
authors.forename: Anushka C
authors.initials: AC
authors.lastname: Galasiti Kankanamalage
authors.affiliation: a Department of Chemistry , Wichita State University , Wichita , KS , USA.
authors.forename: Pathum M
authors.initials: PM
authors.lastname: Weerawarna
authors.affiliation: b Department of Diagnostic Medicine & Pathobiology , Kansas State University , Manhattan , KS , USA.
authors.forename: Yunjeong
authors.initials: Y
authors.lastname: Kim
authors.affiliation: b Department of Diagnostic Medicine & Pathobiology , Kansas State University , Manhattan , KS , USA.
authors.forename: Kyeong-Ok
authors.initials: KO
authors.lastname: Chang
authors.affiliation: a Department of Chemistry , Wichita State University , Wichita , KS , USA.
authors.forename: William C
authors.initials: WC
authors.lastname: Groutas
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D017250:Caliciviridae Infections / Q000188:drug therapy* / Q000821:virology; D015195:Drug Design; D005759:Gastroenteritis / Q000188:drug therapy / Q000821:virology; D006801:Humans; D029322:Norovirus / Q000187:drug effects*; D010330:Patents as Topic
chemical_list: D000998:Antiviral Agents
keywords: 3CL protease inhibitors; Norovirus infection; RdRp inhibitors; attachment and entry inhibitors; host factors