title: Effectiveness of Anise Oil for Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome: A Randomized Active and Placebo-Controlled Clinical Trial.
abstract: Depression is a prevalent disorder among patients suffering from irritable bowel syndrome. The current study was performed to evaluate the effect of a traditional Persian medicine product, anise oil, in removing the symptoms of mild to moderate depression in patients with irritable bowel syndrome. In a randomized double-blinded active and placebo controlled clinical trial, 120 participants with mild to moderate depression according to the Beck Depression Inventory-II total scores were categorized into 3 equal groups and received anise oil, Colpermin, and placebo. The results at the end of trial (week 4) and follow-up (week 6) demonstrated significant priority against active and placebo groups. Although the mechanism is unknown yet, anise oil could be a promising choice of treatment for depressed patients with irritable bowel syndrome.
authors.affiliation: Department of Traditional Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.|Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Mosaffa-Jahromi
authors.affiliation: Center for Nanotechnology in Drug Delivery and Department of Pharmaceutics, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Ali-Mohammad
authors.initials: AM
authors.lastname: Tamaddon
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Suleiman
authors.initials: S
authors.lastname: Afsharypuor
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Salehi
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Seyed Hassan
authors.initials: SH
authors.lastname: Seradj
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Pasalar@sums.ac.ir tamaddon@sums.ac.ir.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Pasalar
authors.affiliation: Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Jafari
authors.affiliation: Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Kamran Bagheri
authors.initials: KB
authors.lastname: Lankarani
mesh_terms: D000328:Adult; D003863:Depression / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications*; D008297:Male; D008514:Medicine, Arabic; D008875:Middle Aged; D009822:Oils, Volatile / Q000627:therapeutic use*; D028042:Pimpinella; D010938:Plant Oils / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D009822:Oils, Volatile; D010938:Plant Oils
keywords: anise; depression; irritable bowel syndrome; traditional Persian medicine