title: Food Proteins as Source of Opioid Peptides-A Review.
abstract: Traditional opioids, mainly alkaloids, have been used in the clinical management of pain for a number of years but are often associated with numerous side-effects including sedation, dizziness, physical dependence, tolerance, addiction, nausea, vomiting, constipation and respiratory depression which prevent their effective use. Opioid peptides derived from food provide significant advantages as safe and natural alternative due to the possibility of their production using animal and plant proteins as well as comparatively less side-effects. This review aims to discuss the current literature on food-derived opioid peptides focusing on their production, methods of detection, isolation and purification. The need for screening more dietary proteins as a source of novel opioid peptides is emphasized in order to fully understand their potential in pain management either as a drug or as part of diet complementing therapeutic prescription.
authors.forename: Swati
authors.initials: S
authors.lastname: Garg
authors.forename: Kulmira
authors.initials: K
authors.lastname: Nurgali
authors.affiliation: College of Health and Biomedicine, Victoria University, PO Box 14428, Melbourne, Victoria 8001, Australia. Vijay.Mishra@vu.edu.au.
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Mishra
mesh_terms: D000818:Animals; D005502:Food; D006801:Humans; D018847:Opioid Peptides / Q000032:analysis* / Q000302:isolation & purification / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D059408:Pain Management
chemical_list: D018847:Opioid Peptides