title: Protein-energy malnutrition is frequent and precocious in children with cri du chat syndrome.
abstract: Protein-energy malnutrition (PEM) is poorly reported in cri du chat syndrome (CDCS) (OMIM #123450), a genetic disease that causes developmental delay and global growth retardation. The objective was to determine the nutritional status at different ages in children with CDCS and factors associated with PEM. A questionnaire focused on growth and nutritional care was sent to 190 families. Among 36 analyzable questionnaires, growth and nutritional indices compatible with PEM occurred in 47% of patients: 19% before 6 months of age, 24% between 6-12 months and 34% after 12 months. Eight patients received enteral feeding. Speech therapy for swallowing education was performed more often in malnourished children (63% vs. 22%, P < 0.02). PEM is frequent and occurs early in this disease, requiring closed nutritional monitoring.
authors.affiliation: Pédiatrie Multidisciplinaire-Nutrition de l'Enfant, CHU Poitiers, Poitiers, France.
authors.forename: Violaine
authors.initials: V
authors.lastname: Lefranc
authors.affiliation: Pédiatrie Multidisciplinaire-Nutrition de l'Enfant, CHU Poitiers, Poitiers, France.|Inserm, CIC1402, Poitiers, France.|University of Poitiers, Poitiers, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: de Luca
authors.affiliation: Inserm U 1069, Tours, France.|University of Tours, Tours, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Hankard
mesh_terms: D002675:Child, Preschool; D003410:Cri-du-Chat Syndrome / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009752:Nutritional Status; D011502:Protein-Energy Malnutrition / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D011795:Surveys and Questionnaires
keywords: child: patient-reported outcomes; cri du chat syndrome; growth; protein-energy malnutrition