title: CONTRIBUTION OF CEREBRAL VASCULAR ANOMALIES IN HEMORRHAGIC STROKE STRUCTURE IN DIFFERENT RACIAL GROUPS OF YAKUTIA.
abstract: BACKGROUND
  Hemorrhagic stroke (HS) has higher incidence in Asian population compared to Caucasian. The reason for this phenomenon is not clearly understood.
  
  
  OBJECTIVE
  To investigate the contribution of cerebral vascular anomalies in hemorrhagic stroke structurein different racial groups of Yakutia.
  
  
  METHODS
  The study group included 1078 consecutively hospitalized patients with acute HS. A comparative analysis of demographic data and frequency of CVA, which were identified as a cause of HS, was carried out between the group of indigenous patients of Asian race and the group of Caucasian patients.
  
  
  RESULTS
  The proportion of hemorrhage due to rupture of cerebralarterial aneurysms (CAA) in the hospital HS structure was higher in Asians, compared to Caucasians (p = 0.001; OR = 1.7; 95% CL: 1.2-2.4). No difference in the arteriovenous malformations' (AVM) frequency was found between groups (p = 0.345), as well as in age and gender distribution (p = 0.052 and p = 0.759, respectively). The CAA frequency was higher among female patients compared to male in both racial groups (p < 0.0001; OR = 1.71; CI 95% 1.3-2.3).
  
  
  CONCLUSIONS
  In Yakutia, the proportion of hemorrhage due to rupture of cerebral arterial aneurysmsin hemorrhagic stroke structure is higher among indigenous ethnic group of Asian race, compared to Caucasians. No difference in the arteriovenous malformations' frequency was found between racial groups, as well as in age and gender distribution. The cerebral aneurisms' frequency was higher among female patients compared to male in both racial groups. Further studies of cerebral vascular anomalies and stroke risk factors using a population-based data in different racial groups are needed.
authors.forename: S A
authors.initials: SA
authors.lastname: Chugunova
authors.forename: T Y
authors.initials: TY
authors.lastname: Nikolaeva
authors.forename: A
authors.initials: A
authors.lastname: Semenov
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001110:Arctic Regions / Q000453:epidemiology / Q000208:ethnology; D044466:Asian People / Q000208:ethnology / Q000706:statistics & numerical data*; D002543:Cerebral Hemorrhage / Q000453:epidemiology* / Q000208:ethnology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D044382:Population Groups / Q000208:ethnology / Q000706:statistics & numerical data*; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology / Q000208:ethnology; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology* / Q000208:ethnology*; D044465:White People / Q000208:ethnology / Q000706:statistics & numerical data*