title: Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies.
abstract: A continuous process for the synthesis and inline separation of anhydrous trifluoromethyl diazomethane in a single continuous flow process is presented. The diazo building block is generated from the corresponding amine and NaNO2 under acidic, aqueous conditions and subsequently diffuses through a gas-permeable membrane into an organic stream. To avoid storage and transportation of the hazardous compound, a representative downstream process in a packed-bed reactor yielding highly functionalized building blocks was developed.
authors.affiliation: Institute of Chemistry, University of Graz , NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
authors.forename: Bartholomäus
authors.initials: B
authors.lastname: Pieber
authors.affiliation: Institute of Chemistry, University of Graz , NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
authors.forename: C Oliver
authors.initials: CO
authors.lastname: Kappe