title: In vivo evaluation of a simvastatin-loaded nanostructured lipid carrier for bone tissue regeneration.
abstract: Alveolar bone loss has long been a challenge in clinical dental implant therapy. Simvastatin (SV) has been demonstrated to exert excellent anabolic effects on bone. However, the successful use of SV to increase bone formation in vivo largely depends on the local concentration of SV at the site of action, and there have been continuing efforts to develop an appropriate delivery system. Specifically, nanostructured lipid carrier (NLC) systems have become a popular type of encapsulation carrier system. Therefore, SV-loaded NLCs (SNs) (179.4 nm in diameter) were fabricated in this study, and the osteogenic effect of the SNs was evaluated in a critical-sized rabbit calvarial defect. Our results revealed that the SNs significantly enhanced bone formation in vivo, as evaluated by hematoxylin and eosin (HE) staining, immunohistochemistry, and a fluorescence analysis. Thus, this novel nanostructured carrier system could be a potential encapsulation carrier system for SV in bone regeneration applications.
authors.affiliation: Center of Oral Implantology, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, People's Republic of China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Yue
authors.forename: Mao
authors.initials: M
authors.lastname: Niu
authors.forename: Te
authors.initials: T
authors.lastname: Zhang
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.forename: Zhonglei
authors.initials: Z
authors.lastname: Wang
authors.forename: Wangxi
authors.initials: W
authors.lastname: Wu
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Chunhua
authors.initials: C
authors.lastname: Lai
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000473:pathology / Q000628:therapy*; D001861:Bone Regeneration / Q000187:drug effects; D004195:Disease Models, Animal; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000627:therapeutic use; D011817:Rabbits; D019821:Simvastatin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D012886:Skull / Q000293:injuries* / Q000473:pathology
chemical_list: D008055:Lipids; D019821:Simvastatin