title: Correlation between mimecan expression and coronary artery stenosis in patients with coronary heart disease.
abstract: OBJECTIVE
  This study aimed to investigate the correlation between coronary artery stenosis and Mimecan expression in patients with coronary heart disease (CHD).
  
  
  METHODS
  Seventy eight patients with CHD and 80 controls without vascular lesions were recruited into present study. CHD patients were divided into one-vessel CHD subgroup, 2-vessel CHD subgroup and multivessel CHD subgroup. ELISA was performed to detect the expressions of serum Mimecan and nuclear factor kappaB (NF-κB).
  
  
  RESULTS
  When compared with control group, the expressions of serum mimecan gene and NF-κB significantly increased in CHD groups (P < 0.05); When compared with one-vessel and two-vessel CHD subgroups, the expressions of serum mimecan and NF-κB significantly increased in multivessel CHD subgroup (P < 0.05), significant difference was observed among three subgroups (P < 0.05). The expressions of serum mimecan and NF-κB were positively related to the severity of coronary lesions (rmimecan=0.79, rNF-κB=0.83, P < 0.05).
  
  
  CONCLUSIONS
  Increased expressions of serum mimecan and NF-κB in CHD patients are related to cardiac insufficiency, which may be ascribed to the binding of NF-κB to mimecan gene.
authors.affiliation: Department of Geriatrics, Affiliated Huai'ai Hospital of Xuzhou Medical Collage Huai'an, China.
authors.forename: Youdong
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Geriatrics, Affiliated Huai'ai Hospital of Xuzhou Medical Collage Huai'an, China.
authors.forename: Junying
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Geriatrics, Affiliated Huai'ai Hospital of Xuzhou Medical Collage Huai'an, China.
authors.forename: Qingna
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Geriatrics, Affiliated Huai'ai Hospital of Xuzhou Medical Collage Huai'an, China.
authors.forename: Peijing
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Geriatrics, Affiliated Huai'ai Hospital of Xuzhou Medical Collage Huai'an, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Geriatrics, Affiliated Huai'ai Hospital of Xuzhou Medical Collage Huai'an, China.
authors.forename: Hualan
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Geriatrics, Affiliated Huai'ai Hospital of Xuzhou Medical Collage Huai'an, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
keywords: Mimecan gene; coronary artery stenosis; coronary heart disease; nuclear factor κB