title: Expression of Beclin1 in the colonic mucosa tissues of patients with ulcerative colitis.
abstract: To investigate the expression of Beclin1 in the colonic mucosa tissue of patients with ulcerative colitis (UC), which acts as a regulator of autophagy and might play a part in the disease progression potentially. A total of 112 patients were selected from September 2013 to November 2014, and their colonic mucosal tissues were collected as the subject of study. Among them, 75 cases were diagnosed with ulcerative colitis (UC), 37 cases were diagnosed with irritable bowel syndrome (IRS) during the same time, which was set as the control group. The mucosal tissues were processed with ELISA and IHCA to measure the expression level of Beclin1, and correlation analysis was performed to demonstrate its role in the disease progression. The expression level pf Beclin1 was significantly higher in the UC patients compared with the control group (P<0.05). Meanwhile, it's positively correlated with the severity of disease, the endoscopic classification and the pathologic staging results, which has statistical significance (P<0.05). Beclin1 was expressed at a higher level in UC patients, and correlated with the severity of the disease, indicating the abnormal regulation of autophagy in the disease progression.
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Qingdao UniversityQingdao 266003, China; Department of Gastroenterology, Weifang Traditional Chinese HospitalWeifang 261041, China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Hao
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Weifang Medical University Weifang 261031, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Weifang Traditional Chinese Hospital Weifang 261041, China.
authors.forename: Xingshan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Weifang Traditional Chinese Hospital Weifang 261041, China.
authors.forename: Huixiang
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Qingdao University Qingdao 266003, China.
authors.forename: Xishuang
authors.initials: X
authors.lastname: Liu
keywords: Beclin1; autophagy; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis