title: Asymmetric Synthesis of Monofluorinated 1-Amino-1,2-dihydronaphthalene and 1,3-Amino Alcohol Derivatives.
abstract: Enantioenriched 1-amino-4-fluoro-1,2-dihydronaphthalene derivatives are accessed via two complementary synthetic strategies. The careful optimization of the reaction conditions required for the elimination step in one route has allowed both the identification of an anchimerically assisted reaction pathway and, more importantly, access to a divergent reaction pathway toward fluorinated 1,3-amino alcohols from a common intermediate just by adjusting the number of equivalents of base used.
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia , E-46100 Burjassot, Spain.|Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe , E-46012 Valencia, Spain.
authors.forename: Rubén
authors.initials: R
authors.lastname: Lázaro
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia , E-46100 Burjassot, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Román
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia , E-46100 Burjassot, Spain.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Sedgwick
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität , Corrensstrasse 40, D-48149 Münster, Germany.
authors.forename: Günter
authors.initials: G
authors.lastname: Haufe
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia , E-46100 Burjassot, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Barrio
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia , E-46100 Burjassot, Spain.|Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe , E-46012 Valencia, Spain.
authors.forename: Santos
authors.initials: S
authors.lastname: Fustero