title: A New Bithiophene from the Root of Echinops grijsii.
abstract: A new bithiophene, 5-(4-hydroxy-3-methoxy-1-butyny)-2,2'-bithiophene (1), and sixteen known thiophenes: 2-(3,4-dihydroxybut-1-ynyl)-5-(penta-1,3-diynyl)thiophene (2), α-terthienyl (3), 5-(3,4-dihydroxybut-1-ynyl)-2,2'-bithiophene (4), 5-acetyl-2,2'-bithiophene (5), 5-formyl-2,2'-bithiophene (6), methyl 2,2'-bithiophene-5-carboxylate (7), 5-(but-3-en-1-ynyl)-2,2'-bithiophene (8), 5-(4-isovaleroyloxybut-1-ynyl)-2,2'-bithiophene (9), cardopatine (10), isocardopatine (11), 5-(3-hydroxy-4-isovaleroyloxybut-1-ynyl)-2,2'-bithiophene (12), 5-(3-hydroxymethyl-3-isovaleroyloxyprop-1-ynyl)-2,2'-bithiophene (13), 5-(4-hydroxy-1-butynyl)-2,2'-bithiophene (14), 5-(4-acetoxy-1-butynl)-2,2'-bithiophene (15), 2,2'-bithiophene-5-carboxylic acid (16) and 2-(4-hydroxybut-1-ynyl)-5-(penta-1,3-diynyl)thiophene (17) were isolated from the roots of Echinops grjisii Hance. Among them, compounds 6, 7 and 16 were isolated from a natural source for the first time. Compounds 2, 4 and 14 exhibited significant anti-inflammatory activity against nitrite of LPS-stimulated production in the RAW 264.7 cell line.
authors.forename: Fang-Pin
authors.initials: FP
authors.lastname: Chang
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Chen
authors.forename: Hui-Chi
authors.initials: HC
authors.lastname: Huang
authors.forename: Sheng-Yang
authors.initials: SY
authors.lastname: Wang
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Chang-Syun
authors.initials: CS
authors.lastname: Yang
authors.forename: Chung-Yi
authors.initials: CY
authors.lastname: Ou
authors.forename: Jin-Bin
authors.initials: JB
authors.lastname: Wu
authors.forename: Guan-Jhong
authors.initials: GJ
authors.lastname: Huang
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D031182:Echinops Plant / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D000067996:RAW 264.7 Cells; D013876:Thiophenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D013876:Thiophenes