title: Side-gated ultrathin-channel nanopore FET sensors.
abstract: A side-gated, ultrathin-channel nanopore FET (SGNAFET) is proposed for fast and label-free DNA sequencing. The concept of the SGNAFET comprises the detection of changes in the channel current during DNA translocation through a nanopore and identifying the four types of nucleotides as a result of these changes. To achieve this goal, both p- and n-type SGNAFETs with a channel thicknesses of 2 or 4 nm were fabricated, and the stable transistor operation of both SGNAFETs in air, water, and a KCl buffer solution were confirmed. In addition, synchronized current changes were observed between the ionic current through the nanopore and the SGNAFET's drain current during DNA translocation through the nanopore.
authors.affiliation: Hitachi Ltd, Research & Development Group, Center for Technology Innovation-Healthcare, 1-280, Higashi-Koigakubo, Kokubunji, Tokyo, 185-8603, Japan.
authors.forename: Itaru
authors.initials: I
authors.lastname: Yanagi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Oura
authors.forename: Takanobu
authors.initials: T
authors.lastname: Haga
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ando
authors.forename: Jiro
authors.initials: J
authors.lastname: Yamamoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Mine
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishida
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hatano
authors.forename: Rena
authors.initials: R
authors.lastname: Akahori
authors.forename: Takahide
authors.initials: T
authors.lastname: Yokoi
authors.forename: Takashi
authors.initials: T
authors.lastname: Anazawa
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D058608:Nanopores; D009711:Nucleotides / Q000032:analysis; D017422:Sequence Analysis, DNA / Q000295:instrumentation*
chemical_list: D009711:Nucleotides