title: 4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior.
abstract: Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological and optogenetic manipulations, we found that freezing, a behavioral expression of fear, temporally coincided with the development of sustained, internally generated 4-Hz oscillations in prefrontal-amygdala circuits. 4-Hz oscillations predict freezing onset and offset and synchronize prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4-Hz oscillations coordinates prefrontal-amygdala activity and elicits fear behavior. These results unravel a sustained oscillatory mechanism mediating prefrontal-amygdala coupling during fear behavior.
authors.affiliation: INSERM, Neurocentre Magendie, U862, Bordeaux, France.|Univ. Bordeaux, Neurocentre Magendie, U862, Bordeaux, France.|Bernstein Center for Computational Neuroscience Munich, Munich Cluster of Systems Neurology (SyNergy), Faculty of Medicine, Ludwig-Maximilians Universität München, Planegg-Martinsried, Germany.
authors.forename: Nikolaos
authors.identifier: http://orcid.org/0000-0002-1804-9756
authors.initials: N
authors.lastname: Karalis
authors.affiliation: INSERM, Neurocentre Magendie, U862, Bordeaux, France.|Univ. Bordeaux, Neurocentre Magendie, U862, Bordeaux, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Dejean
authors.affiliation: INSERM, Neurocentre Magendie, U862, Bordeaux, France.|Univ. Bordeaux, Neurocentre Magendie, U862, Bordeaux, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Chaudun
authors.affiliation: INSERM, Neurocentre Magendie, U862, Bordeaux, France.|Univ. Bordeaux, Neurocentre Magendie, U862, Bordeaux, France.
authors.forename: Suzana
authors.initials: S
authors.lastname: Khoder
authors.affiliation: INSERM, Neurocentre Magendie, U862, Bordeaux, France.|Univ. Bordeaux, Neurocentre Magendie, U862, Bordeaux, France.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Rozeske
authors.affiliation: INSERM, Neurocentre Magendie, U862, Bordeaux, France.|Univ. Bordeaux, Neurocentre Magendie, U862, Bordeaux, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Wurtz
authors.affiliation: Team Memory, Oscillations and Brain states (MOBs), Brain Plasticity Unit, CNRS UMR 8249, ESPCI ParisTech, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, Paris, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Bagur
authors.affiliation: Team Memory, Oscillations and Brain states (MOBs), Brain Plasticity Unit, CNRS UMR 8249, ESPCI ParisTech, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, Paris, France.
authors.forename: Karim
authors.initials: K
authors.lastname: Benchenane
authors.affiliation: Bernstein Center for Computational Neuroscience Munich, Munich Cluster of Systems Neurology (SyNergy), Faculty of Medicine, Ludwig-Maximilians Universität München, Planegg-Martinsried, Germany.
authors.forename: Anton
authors.initials: A
authors.lastname: Sirota
authors.affiliation: INSERM, Neurocentre Magendie, U862, Bordeaux, France.|Univ. Bordeaux, Neurocentre Magendie, U862, Bordeaux, France.|Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
authors.forename: Julien
authors.initials: J
authors.lastname: Courtin
authors.affiliation: INSERM, Neurocentre Magendie, U862, Bordeaux, France.|Univ. Bordeaux, Neurocentre Magendie, U862, Bordeaux, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Herry
mesh_terms: D000161:Acoustic Stimulation / Q000009:adverse effects; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology; D005108:Extinction, Psychological / Q000502:physiology; D005239:Fear / Q000502:physiology* / Q000523:psychology*; D008297:Male; D051379:Mice; D057507:Mice, 129 Strain; D008810:Mice, Inbred C57BL; D009434:Neural Pathways / Q000502:physiology; D062308:Optogenetics / Q000379:methods*; D017397:Prefrontal Cortex / Q000502:physiology*