title: Polymer Drug Conjugates: Recent Advancements in Various Diseases.
abstract: During the past decade, the arena of polymer therapeutics has acquired considerable interest and accompanied by advanced designs and chemical properties of polymer-drug conjugates. Various polymers, such as poly (ethylene glycol) (PEG), N-(2-hydroxypropyl) methacrylamide (HPMA), poly(glycolic acid) (PGA) and poly(lactide-co-glycolide) (PLGA) have been used successfully for clinical utilization from decades. These polymers are used in combination of drugs in such a manner that they target the specific tissues and thus the toxicity of drugs to other tissues is reduced. Presently, numerous polymer drug conjugates are under clinical trial for treatment of various diseases including cancer, diabetes, AIDS, rheumatoid arthritis etc. Many protein-polymer conjugates have been approved by FDA for clinical use but till date, no polymer-synthetic drug conjugate is approved by FDA, although many of them are undergoing final phase of clinical trials. This review highlights the recent advancements in the polymer-drug conjugates for treatment of various diseases and their preclinical and clinical status.
authors.forename: Jasbir
authors.initials: J
authors.lastname: Singh
authors.forename: Sapna
authors.initials: S
authors.lastname: Desai
authors.forename: Snehlata
authors.initials: S
authors.lastname: Yadav
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Narasimhan
authors.affiliation: Department of Pharmaceutical Sciences, M.D. University, Rohtak-124001, India. bawideepi@yahoo.co.in.
authors.forename: Harmeet
authors.initials: H
authors.lastname: Kaur
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D003920:Diabetes Mellitus / Q000188:drug therapy; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D004364:Pharmaceutical Preparations; D011108:Polymers