title: Overexpression of STAT3/pSTAT3 was associated with poor prognosis in gastric cancer: a meta-analysis.
abstract: Signal transducer and activator of transcription 3 (STAT3) and phospho-STAT3 (pSTAT3) play important roles in the development of gastric cancer. STAT3 is often associated with cell survival, proliferation, and transformation. The prognostic value of STAT3/pSTAT3 in patients with gastric cancer remains controversial in numerous published studies. The aim of this study was to summarize recent findings relevant to the prognostic role of STAT3 and pSTAT3 in patients with gastric cancer. A meta-analysis was performed by searching Web of Knowledge, EMBASE, and PubMed to identify studies on the prognostic impact of STAT3/pSTAT3 in gastric cancers in August 2014. In all, 10 studies were included in the analysis. Data were collected for comparing survival rates in patients with high STAT3 levels compared to those with low levels. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. Sensitivity analysis was conducted, and publication bias was evaluated. Eventually, 1667 cases of gastric cancer were subjected to the final analysis. Among patients with gastric cancer, poor survival was predicted by higher expressions of STAT3 (HR=2.30; 95% CI=1.13-4.68; P=0.02) and pSTAT3 (HR=1.75; 95% CI=1.17-2.61; P=0.006). Moreover, overexpression of STAT3 was associated with poor tumor stage. Additionally, our analysis did not show any statistically significant effect of publication bias regarding STAT3 or pSTAT3. The results of this meta-analysis demonstrated that overexpression of STAT3 and pSTAT3 was associated with poor prognosis in gastric cancer.
authors.affiliation: Department of Oncology, The People's Hospital of GanzhouGanzhou, China; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University1838 North Guangzhou Avenue, Guangzhou, China; Department of Oncology, The Affiliated Hospital of Guilin Medical College GuilinChina.
authors.forename: Shaozhong
authors.initials: S
authors.lastname: He
authors.affiliation: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University1838 North Guangzhou Avenue, Guangzhou, China; Department of Radiation Oncology, The People's Hospital of Shen Zhen, Jinan UniversityChina.
authors.forename: Guixiang
authors.initials: G
authors.lastname: Liao
authors.affiliation: Department of Oncology, The People's Hospital of Ganzhou Ganzhou, China.
authors.forename: Yungen
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome Largo F. Vito, Rome, Italy.
authors.forename: Liling
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Oncology, The Affiliated Hospital of Guilin Medical College Guilin China.
authors.forename: Mafei
authors.initials: M
authors.lastname: Kang
authors.affiliation: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University 1838 North Guangzhou Avenue, Guangzhou, China.
authors.forename: Longhua
authors.initials: L
authors.lastname: Chen
keywords: Gastric cancer; meta-analysisjr; prognosis; signal transducer and activator of transcription 3