title: A Ten-Year Review of Antenatal Complications and Pregnancy Outcomes Among HIV-Positive Pregnant Women.
abstract: OBJECTIVE
  To review the incidence of antenatal complications among a cohort of HIV-positive pregnant women over a 10-year period.
  
  
  METHODS
  A retrospective review was performed of all HIV-positive pregnant women receiving multidisciplinary prenatal care at an urban tertiary care centre from March 2000 to March 2010. Collected data included the presence of additional infectious or medical conditions, genetic screening information, and the presence or absence of antenatal complications.
  
  
  RESULTS
  One hundred and forty-two singleton pregnancies during the study period were identified. Almost 95% of women were taking combination antiretroviral therapy during pregnancy, and greater than 90% had viral loads less than 1000 copies/ml at delivery. The presence of co-infections was low. Forty-one women (29%) had other medical comorbidities. Genetic screening occurred in 104 pregnancies (73%); 4% were abnormal screens. Rates of any hypertension, gestational diabetes, and fetal growth restriction were all low. Thirty-two percent of women were colonized with group B streptococcus.
  
  
  CONCLUSIONS
  This study adds strength to the argument that good outcomes can be achieved for HIV-positive pregnant women with good access to both prenatal and HIV care, and appropriate management. Women with HIV should be optimally cared for in advance of and during pregnancy in order to maximize the likelihood of good pregnancy outcomes.
authors.affiliation: Department of Obstetrics and Gynecology, St. Michael's Hospital, University of Toronto, Toronto, ON.
authors.forename: Mark H
authors.initials: MH
authors.lastname: Yudin
authors.affiliation: Department of Obstetrics and Gynecology, St. Michael's Hospital, University of Toronto, Toronto, ON.
authors.forename: Daniela
authors.initials: D
authors.lastname: Caprara
authors.affiliation: Department of Obstetrics and Gynecology, St. Michael's Hospital, University of Toronto, Toronto, ON.
authors.forename: S Jay
authors.initials: SJ
authors.lastname: MacGillivray
authors.affiliation: Keenan Research Centre, Li Ka Shing Knowledge Institute, University of Toronto, Toronto, ON.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Urquia
authors.affiliation: Department of Obstetrics and Gynecology, St. Michael's Hospital, University of Toronto, Toronto, ON.
authors.forename: Rajiv R
authors.initials: RR
authors.lastname: Shah
mesh_terms: D000328:Adult; D000416:Alberta / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011295:Prenatal Care / Q000379:methods / Q000592:standards; D011296:Prenatal Diagnosis / Q000379:methods; D058996:Quality Improvement; D012189:Retrospective Studies; D019562:Viral Load / Q000379:methods
keywords: HIV; pregnancy; pregnancy complications; pregnancy outcomes