title: Basic Principles of Lyophilization, Part 1.
abstract: The achievement of a high-quality lyophilized (freeze-dried) dosage form involves the combination of optimal formulation design and optimal freeze-dry cycle design. This 2-part article describes how this can be done. Part 1 discusses the basic principles and procedures of lyophilization up to a discussion on the different stages of lyophilization. The stages of lyophilization are discussed in part 2.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Akers
mesh_terms: D002626:Chemistry, Pharmaceutical; D003080:Cold Temperature; D004304:Dosage Forms; D004339:Drug Compounding; D004355:Drug Stability; D004356:Drug Storage; D005612:Freeze Drying; D005615:Freezing; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors; D014867:Water / Q000737:chemistry*
chemical_list: D004304:Dosage Forms; D004364:Pharmaceutical Preparations; D014867:Water