title: Correlation of polymorphism of APOE and LRP genes to cognitive impairment and behavioral and psychological symptoms of dementia in Alzheimer's disease and vascular dementia.
abstract: OBJECTIVE
  To discuss the correlation of polymorphism of APOE and LRP genes to cognitive impairment and behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) and vascular dementia (VD).
  
  
  METHODS
  AD cases, VD cases and healthy control cases totaling 237, 255 and 234 were recruited, respectively. The mini-mental state examination (MMSE) was performed to evaluate cognitive impairment. Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were adopted to evaluate BPSD. Apolipoprotein E (APOE) and Low-density lipoprotein receptor-related protein gene (LRP) genotyping was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  (1) Frequencies of APOEε4 allele in AD group and VD group were significantly higher than that of the control (P<0.05); (2) MMSE scores of APOEε4 carriers in AD group and VD group were lower than that of non-APOEε4 carriers in the same group (P<0.05); (3) The proportion of APOEε4 carriers presenting with BPSD in AD group was considerably higher that of non-APOEε4 carriers (P<0.05).
  
  
  CONCLUSIONS
  APOEε4 may be the common risk factor for cognitive impairment in AD and VD and the risk factor for BPSD in AD.
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University No. 9677, Jingshi Road, Jinan 250021, Shandong, China.
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Mou
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University No. 9677, Jingshi Road, Jinan 250021, Shandong, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Han
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University No. 9677, Jingshi Road, Jinan 250021, Shandong, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University No. 9677, Jingshi Road, Jinan 250021, Shandong, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University No. 9677, Jingshi Road, Jinan 250021, Shandong, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Yantaishan Hospital No. 91, Jiefang Road, Zhifu, Yantai 264000, Shandong, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Hu
keywords: APOE gene; Alzheimer’s disease (AD); LRP gene; vascular dementia (VD)