title: A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage.
abstract: Association of a high-serum ferritin with poor outcome showed that iron might play a detrimental role in the brain after intracerebral hemorrhage (ICH). Here, we investigated changes in serum iron, ferritin, transferrin (Tf) and ceruloplasmin (CP) in patients with ICH (n = 100) at day 1 (admission), 3, 7, 14 and 21 and those in control subjects (n = 75). The hematoma and edema volumes were also determined in ICH-patients on admission and at day 3. The Modified Rankin Scale (mRS) of 59 patients was ≥3 (poor outcome) and 41 < 3 (good outcome) at day 90. Serum ferritin was significantly higher and serum iron and Tf markedly lower in patients with poor-outcome than the corresponding values in patients with good-outcome at day 1 to 7 and those in the controls. There was a significant positive correlation between serum ferritin and relative edema volume or ratio at day 1 and 3 and hematoma volume at day 1 (n = 28), and a negative correlation between serum iron or Tf and hematoma volume at day 1 (n = 100). We concluded that not only increased serum ferritin but also reduced serum iron and Tf are associated with outcome as well as hematoma volume.
authors.affiliation: Department of Neurosurgery, South-west Hospital, The Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China.|Laboratory of Neuropharmacology, Fudan University School of Pharmacy, Shanghai 201203, PRC.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, South-west Hospital, The Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
authors.affiliation: Department of Neurosurgery, South-west Hospital, The Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.
authors.forename: Christopher
authors.initials: C
authors.lastname: Qian
authors.affiliation: Laboratory of Neuropharmacology, Fudan University School of Pharmacy, Shanghai 201203, PRC.
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Luo
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.
authors.forename: Wing-Ho
authors.initials: WH
authors.lastname: Yung
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Ke
authors.affiliation: Department of Neurosurgery, South-west Hospital, The Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Feng
authors.affiliation: Department of Neurosurgery, South-west Hospital, The Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China.|Laboratory of Neuropharmacology, Fudan University School of Pharmacy, Shanghai 201203, PRC.
authors.forename: Zhong-Ming
authors.initials: ZM
authors.lastname: Qian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D002570:Ceruloplasmin / Q000378:metabolism; D005260:Female; D005293:Ferritins / Q000097:blood*; D006406:Hematoma / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014168:Transferrin / Q000378:metabolism*
chemical_list: D014168:Transferrin; D005293:Ferritins; D007501:Iron; D002570:Ceruloplasmin