title: Anti-VEGF and its impact on the outer retina: retinal pigment epithelium tear after an injection of aflibercept in contralateral eye.
abstract: METHODS
  A 62-year-old woman with a history of bilateral retinal pigment epithelium detachment (PED), secondary of age-related macular degeneration (AMD), who presented with a retinal pigment epithelium (RPE) tear on her left eye after an aflibercept injection in the contralateral eye one month earlier.
  
  
  CONCLUSIONS
  A RPE tear is the main complication when the anti-VEGF therapy is used for the management of the PED. Furthermore, it should be noted that systemic absorption of the drug can induce an effect on the untreated eye.
authors.affiliation: Servicio de Oftalmología, Hospital Virgen del Puerto, Plasencia, Cáceres, España. Electronic address: rafacampospolo@hotmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Campos Polo
authors.affiliation: Servicio de Oftalmología, Hospital Virgen del Puerto, Plasencia, Cáceres, España.
authors.forename: C
authors.initials: C
authors.lastname: Rubio Sánchez
mesh_terms: D005260:Female; D006801:Humans; D056965:Injections, Intraocular; D008875:Middle Aged; D040262:Receptors, Vascular Endothelial Growth Factor / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage / Q000009:adverse effects*; D055213:Retinal Pigment Epithelium / Q000293:injuries*
chemical_list: D011993:Recombinant Fusion Proteins; C533178:aflibercept; D040262:Receptors, Vascular Endothelial Growth Factor
keywords: Aflibercept; Age-related macular degeneration; Anti-VEGF; Degeneración macular asociada a la edad; Desprendimiento del epitelio pigmentario de la retina; Retinal pigment epithelium detachment; Retinal pigment epithelium tear; Rotura del epitelio pigmentario de la retina