title: The Chinese Herbal Medicine Formula mKG Suppresses Pulmonary Fibrosis of Mice Induced by Bleomycin.
abstract: Pulmonary fibrosis (PF) is a serious progressive lung disease and it originates from inflammation-induced parenchymal injury with excessive extracellular matrix deposition to result in the destruction of the normal lung architecture. Modified Kushen Gancao Formula (mKG), derived from traditional Chinese herbal medicine, has a prominent anti-inflammatory effect. The present study is to explore the inhibitory effects of mKG on bleomycin (BLM)-induced pulmonary fibrosis in mice. mKG significantly decreased pulmonary alveolitis, fibrosis scores, and interleukin-6 (IL-6), interleukin-17 (IL-17), transforming growth factor-β (TGF-β) and hydroxyproline (HYP) levels in lung tissue of mice compared with BLM treatment. It markedly alleviated the increase of HYP content in the lung tissues and pathologic changes of pulmonary fibrosis caused by BLM instillation. In conclusion, mKG has an anti-fibrotic effect and might be employed as a therapeutic candidate agent for attenuating pulmonary fibrosis.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. gying77@163.com.|Department of Pharmacy, Logistics College of Chinese People's Armed Police Force, Tianjin 300309, China. gying77@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Pharmacy, Logistics College of Chinese People's Armed Police Force, Tianjin 300309, China. leaf_yao@126.com.
authors.forename: Li-Fu
authors.initials: LF
authors.lastname: Yao
authors.affiliation: Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. youngzhao91@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. weilim13311035797@163.com.
authors.forename: Li-Man
authors.initials: LM
authors.lastname: Wei
authors.affiliation: Department of Pharmacy, Logistics College of Chinese People's Armed Police Force, Tianjin 300309, China. guopengtj@163.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Guo
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. yumeng.5555@163.com.
authors.forename: Meng
authors.initials: M
authors.lastname: Yu
authors.affiliation: Department of Pharmacy, Logistics College of Chinese People's Armed Police Force, Tianjin 300309, China. caobo19814@126.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Cao
authors.affiliation: Department of Pharmacy, Logistics College of Chinese People's Armed Police Force, Tianjin 300309, China. tanli20042001@163.com.
authors.forename: Tan
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Pharmacy, Logistics College of Chinese People's Armed Police Force, Tianjin 300309, China. chenhongtian06@163.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. zmzou@implad.ac.cn.
authors.forename: Zhong-Mei
authors.initials: ZM
authors.lastname: Zou
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015870:Gene Expression; D007150:Immunohistochemistry; D018836:Inflammation Mediators; D008297:Male; D051379:Mice; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D000199:Actins; D000903:Antibiotics, Antineoplastic; D016207:Cytokines; D004365:Drugs, Chinese Herbal; D018836:Inflammation Mediators; D012333:RNA, Messenger; D001761:Bleomycin; C494416:kushen
keywords: bleomycin; mKG (Modified Kushen Gancao Formula); mice; pulmonary fibrosis