title: Programmable DNA Hydrogels Assembled from Multidomain DNA Strands.
abstract: Hydrogels are important in biological and medical applications, such as drug delivery and tissue engineering. DNA hydrogels have attracted significant attention due to the programmability and biocompatibility of the material. We developed a series of low-cost one-strand DNA hydrogels self-assembled from single-stranded DNA monomers containing multiple palindromic domains. This new hydrogel design is simple and programmable. Thermal stability, mechanical properties, and loading capacity of these one-strand DNA hydrogels can be readily regulated by simply adjusting the DNA domains.
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Emory School of Medicine, 1760 Haygood Drive, Atlanta, Georgia, 30322, USA.
authors.forename: Huiling
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Emory School of Medicine, 1760 Haygood Drive, Atlanta, Georgia, 30322, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Pan
authors.affiliation: Emory University, Department of Physics, 400 Dowman Drive, Atlanta, GA, 30322-2430, USA.
authors.forename: Skanda
authors.initials: S
authors.lastname: Vivek
authors.affiliation: Emory University, Department of Physics, 400 Dowman Drive, Atlanta, GA, 30322-2430, USA.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Weeks
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Emory School of Medicine, 1760 Haygood Drive, Atlanta, Georgia, 30322, USA. yonggang.ke@emory.edu.
authors.forename: Yonggang
authors.identifier: 0000-0003-1673-2153
authors.initials: Y
authors.lastname: Ke
mesh_terms: D004247:DNA / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D005456:Fluorescent Dyes / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D012212:Rheology; D044366:Transition Temperature
chemical_list: D005456:Fluorescent Dyes; D020100:Hydrogels; D004247:DNA
keywords: DNA nanotechnology; hydrogel; programmable nanomaterials