title: Decompressive craniectomy in neurocritical care.
abstract: Recently, several randomized controlled trials (RCT) investigating the effectiveness of decompressive craniectomy in the context of neurocritical illnesses have been completed. Thus, a meta-analysis to update the current evidence regarding the effects of decompressive craniectomy is necessary. We searched PUBMED, EMBASE and the Cochrane Central Register of Controlled Trials. Other sources, including internet-based clinical trial registries and grey literature, were also searched. After searching the literature, two investigators independently performed literature screening, assessing the quality of the included trials and extracting the data. The outcome measures included the composite outcome of death or dependence and the risk of death. Ten RCT were included: seven RCT were on malignant middle cerebral artery infarction (MCAI) and three were on severe traumatic brain injury (TBI). Decompressive craniectomy significantly reduced the risk of death for patients suffering malignant MCAI (risk ratio [RR] 0.46, 95% confidence interval [CI]: 0.36-0.59, P<0.00001) in comparison with no reduction in the risk of death for patients with severe TBI (RR: 0.83, 95% CI: 0.48-1.42, P=0.49). However, there was no significant difference in the composite risk of death or dependence at the final follow-up between the decompressive craniectomy group and the conservative treatment group for either malignant MCAI or severe TBI. The present meta-analysis indicates that decompressive craniectomy can significantly reduce the risk of death for patients with malignant MCAI, although no evidence demonstrates that decompressive craniectomy is associated with a reduced risk of death or dependence for TBI patients.
authors.affiliation: Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical University, 8 South Gongti Road, Beijing 100020, PR China.
authors.forename: Jia-Wei
authors.initials: JW
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical University, 8 South Gongti Road, Beijing 100020, PR China.
authors.forename: Jin-Ping
authors.initials: JP
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical University, 8 South Gongti Road, Beijing 100020, PR China.
authors.forename: Ying-Lun
authors.initials: YL
authors.lastname: Song
authors.affiliation: Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical University, 8 South Gongti Road, Beijing 100020, PR China.
authors.forename: Ke
authors.initials: K
authors.lastname: Tan
authors.affiliation: Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical University, 8 South Gongti Road, Beijing 100020, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical University, 8 South Gongti Road, Beijing 100020, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical University, 8 South Gongti Road, Beijing 100020, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Guo
authors.affiliation: Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical University, 8 South Gongti Road, Beijing 100020, PR China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical University, 8 South Gongti Road, Beijing 100020, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical University, 8 South Gongti Road, Beijing 100020, PR China. Electronic address: chaoyanghospital@126.com.
authors.forename: Qi-Huang
authors.initials: QH
authors.lastname: Zhao
mesh_terms: D000070642:Brain Injuries, Traumatic / Q000601:surgery*; D056424:Decompressive Craniectomy / Q000379:methods*; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000601:surgery*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
keywords: Decompressive craniectomy; Meta-analysis; Neurocritical illness; Randomized controlled trial; Stroke; Traumatic brain injury