title: Synthesis and Multibromination of Nanosized Helical Aromatic Amide Foldamers via Segment-Doubling Condensation.
abstract: The synthesis of very long helical aromatic amide foldamers was thought to be limited by steric hindrance associated with stable folded conformations. This difficulty may be overcome by using pure reagents, relatively high concentrations, and long reaction times. Bromine substituents and careful identification and elimination of anhydride byproducts both greatly improve chromatographic purification, giving access to pure products amenable to a segment-doubling synthesis of sequences composed of up to 96 monomers. An efficient one-pot multibromination of helical oligomers is also reported.
authors.affiliation: Department of Chemistry, University of Liège , B6a Sart-Tilman, 4000 Liège, Belgium.
authors.forename: Xuesong
authors.initials: X
authors.lastname: Li
authors.affiliation: CBMN (UMR 5248), CNRS , 33600 Pessac, France.
authors.forename: Ting
authors.initials: T
authors.lastname: Qi
authors.affiliation: CBMN (UMR 5248), CNRS , 33600 Pessac, France.
authors.forename: Kolupula
authors.initials: K
authors.lastname: Srinivas
authors.affiliation: IECB (UMS 3033), CNRS , 33600 Pessac, France.|IECB (US001), INSERM , 33600 Pessac, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Massip
authors.affiliation: CBMN (UMR 5248), CNRS , 33600 Pessac, France.
authors.forename: Victor
authors.initials: V
authors.lastname: Maurizot
authors.affiliation: CBMN (UMR 5248), CNRS , 33600 Pessac, France.
authors.forename: Ivan
authors.initials: I
authors.lastname: Huc