title: Profile of Free Fatty Acids and Fractions of Phospholipids, Cholesterol Esters and Triglycerides in Serum of Obese Youth with and without Metabolic Syndrome.
abstract: The study evaluated the profile of circulating fatty acids (FA) in obese youth with and without metabolic syndrome (MetS) to determine its association with nutritional status, lifestyle and metabolic variables. A cross-sectional study was conducted in 96 young people, divided into three groups: obese with MetS (OBMS), obese (OB) and appropriate weight (AW). FA profiles were quantified by gas chromatography; waist circumference (WC), fat folds, lipid profile, high-sensitivity C-reactive protein, glucose, insulin, the homeostasis model assessment (HOMA index), food intake and physical activity (PA) were assessed. The OBMS group had significantly greater total free fatty acids (FFAs), palmitic-16:0 in triglyceride (TG), palmitoleic-16:1n-7 in TG and phospholipid (PL); in the OB group, these FAs were higher than in the AW group. Dihomo-gamma-linolenic (DHGL-20:3n-6) was higher in the OBMS than the AW in PL and FFAs. Linoleic-18:2n-6 in TG and PL had the lowest proportion in the OBMS group. WC, PA, total FFA, linoleic-18:2n-6 in TG and DHGL-20:3n-6 in FFAs explained 62% of the HOMA value. The OB group presented some higher proportions of FA and biochemical values than the AW group. The OBMS had proportions of some FA in the TG, PL and FFA fractions that correlated with disturbances of MetS.
authors.affiliation: Research Group in Food and Human Nutrition, Universidad de Antioquia (UdeA), Calle 70 No. 52-21 Medellín 050010238, Colombia. juliana.bermudez@udea.edu.co.
authors.forename: Juliana
authors.initials: J
authors.lastname: Bermúdez-Cardona
authors.affiliation: Research Group in Food and Human Nutrition, Universidad de Antioquia (UdeA), Calle 70 No. 52-21 Medellín 050010238, Colombia. claudia.velasquez@udea.edu.co.
authors.forename: Claudia
authors.initials: C
authors.lastname: Velásquez-Rodríguez
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002788:Cholesterol Esters / Q000097:blood*; D003430:Cross-Sectional Studies; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D063766:Pediatric Obesity / Q000097:blood*; D010743:Phospholipids / Q000097:blood*; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D002788:Cholesterol Esters; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D010743:Phospholipids; D014280:Triglycerides; D002097:C-Reactive Protein
keywords: fatty acids; metabolic syndrome; obesity; serum; youth