title: A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population.
abstract: Prostate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated Chinese population, we performed single-nucleotide polymorphism (SNP) array analysis on a cohort of Chinese cases and controls and then meta-analysis with data from the existing Chinese prostate cancer genome-wide association study (GWAS). Genotyping 211,155 SNPs in 495 cases and 640 controls of Chinese ancestry identified several new suggestive Chinese prostate cancer predisposition loci. However, none of them reached genome-wide significance level either by meta-analysis or replication study. The meta-analysis with the Chinese GWAS data revealed that four 8q24 loci are the main contributors to Chinese prostate cancer risk and the risk alleles from three of them exist at much higher frequencies in Chinese than European populations. We also found that several predisposition loci reported in Western populations have different effect on Chinese men. Therefore, this first extensive single-nucleotide polymorphism study of Chinese prostate cancer in comparison with European population indicates that four loci on 8q24 contribute to a great risk of prostate cancer in a considerable large proportion of Chinese men. Based on those four loci, the top 10% of the population have six- or two-fold prostate cancer risk compared with men of the bottom 10% or median risk respectively, which may facilitate the design of prostate cancer genetic risk screening and prevention in Chinese men. These findings also provide additional insights into the etiology and pathogenesis of prostate cancer.
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
authors.forename: Jacek
authors.initials: J
authors.lastname: Marzec
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
authors.forename: Xueying
authors.initials: X
authors.lastname: Mao
authors.affiliation: Department of Epidemiology, Second Military Medical University, Shanghai, 200433, China.
authors.forename: Meiling
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Molecular and Genetic Toxicology, The Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Urology, Wuxi Second People's Hospital, Nanjing Medical University, Wuxi, 214002, China.|Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Ninghan
authors.initials: N
authors.lastname: Feng
authors.affiliation: Department of Urology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Gou
authors.affiliation: Department of Urology, Zhongshan Hospital, Fudan University Medical College, Shanghai, 200032, China.
authors.forename: Guomin
authors.initials: G
authors.lastname: Wang
authors.affiliation: Liaoning People's Hospital and Center of Experiment and Technology, China Medical University, Shenyang, 110001, China.
authors.forename: Zan
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Program for Personalized Cancer Care, North Shore University Health System, Evanston, IL 60201, U.S.A.|Fudan Institute of Urology, Huashang Hospital, Fudan University, Shanghai, 200040, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Urology, Tongji Hospital, Huazhong Science and Technology University, Wuhan, 430030, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Urology, Xiehe Hospital, Huazhong Science and Technology University, Wuhan, 430022, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Shan-Chao
authors.initials: SC
authors.lastname: Zhao
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Zhejiang University Medical College, Hangzhou, 310009, China.
authors.forename: Guoping
authors.initials: G
authors.lastname: Ren
authors.affiliation: Department of Pathology, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, China.
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Urology, First Affiliated Hospital, Medical College, Zhengzhou University, Zhengzhou, 450003, China.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Urology, North Sichuan Medical College, Nanchong, 637000, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Molecular and Genetic Toxicology, The Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Nutrition Science, Shenyang Medical College, Shenyang, 110034, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Zhejiang University Medical College, Hangzhou, 310009, China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, Second Military Medical University, Shanghai, 200433, China.
authors.forename: Xingxing
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Urology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Urology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Weiyang
authors.initials: W
authors.lastname: He
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge-Strangeways Research Laboratory, Cambridge, CB1 8RN, UK.
authors.forename: Sara
authors.initials: S
authors.lastname: Benlloch
authors.affiliation: Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.
authors.forename: Helen
authors.initials: H
authors.lastname: Ross-Adams
authors.affiliation: Department of Urology, Xiehe Hospital, Huazhong Science and Technology University, Wuhan, 430022, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Jucong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Yingqia
authors.initials: Y
authors.lastname: Hong
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK.
authors.forename: Zsofia
authors.initials: Z
authors.lastname: Kote-Jarai
authors.affiliation: Department of Urology, Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, China.
authors.forename: Xingang
authors.initials: X
authors.lastname: Cui
authors.affiliation: Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Urology, Zhongshan Hospital, Fudan University Medical College, Shanghai, 200032, China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Urology, Zhongshan Hospital, Fudan University Medical College, Shanghai, 200032, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Changjun
authors.initials: C
authors.lastname: Yin
authors.affiliation: Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Yuanping
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.
authors.forename: David E
authors.initials: DE
authors.lastname: Neal
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
authors.forename: Tim
authors.initials: T
authors.lastname: Oliver
authors.affiliation: Department of Epidemiology, Second Military Medical University, Shanghai, 200433, China.
authors.forename: Guangwen
authors.initials: G
authors.lastname: Cao
authors.affiliation: Department of Molecular and Genetic Toxicology, The Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge-Strangeways Research Laboratory, Cambridge, CB1 8RN, UK.
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
authors.forename: Claude
authors.initials: C
authors.lastname: Chelala
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge-Strangeways Research Laboratory, Cambridge, CB1 8RN, UK.
authors.forename: Ali Amin
authors.initials: AA
authors.lastname: Al Olama
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK.|The Royal Marsden NHS Foundation Trust, London and Surrey, SM2 5NG, UK.
authors.forename: Rosalind A
authors.initials: RA
authors.lastname: Eeles
authors.affiliation: Department of Epidemiology, Second Military Medical University, Shanghai, 200433, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
authors.forename: Yong-Jie
authors.initials: YJ
authors.lastname: Lu
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005787:Gene Frequency; D056426:Genetic Loci / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
keywords: Chinese prostate cancer; genetic risk; population difference; predisposition; single-nucleotide polymorphism