title: Postoperative Early Major and Minor Complications in Laparoscopic Vertical Sleeve Gastrectomy (LVSG) Versus Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) Procedures: A Meta-Analysis and Systematic Review.
abstract: Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic vertical sleeve gastrectomy (LVSG) have been proposed as cost-effective strategies to manage obesity-related chronic disease. The aim of this meta-analysis and systematic review was to compare the "early postoperative complication rate i.e. within 30-days" reported from randomized control trials (RCTs) comparing these two procedures.
  
  
  
  RCTs comparing the early complication rates following LVSG and LRYGB between 2000 and 2015 were selected from PubMed, Medline, Embase, Science Citation Index, Current Contents, and the Cochrane database. The outcome variables analyzed included 30-day mortality, major and minor complications and interventions required for their management, length of hospital stay, readmission rates, operating time, and conversions from laparoscopic to open procedures.
  
  
  
  Six RCTs involving a total of 695 patients (LVSG n = 347, LRYGB n = 348) reported on early major complications. A statistically significant reduction in relative odds of early major complications favoring the LVSG procedure was noted (p = 0.05). Five RCTs representing 633 patients (LVSG n = 317, LRYGB n = 316) reported early minor complications. A non-statically significant reduction in relative odds of 29 % favoring the LVSG procedure was observed for early minor complications (p = 0.4). However, other outcomes directly related to complications which included reoperation rates, readmission rate, and 30-day mortality rate showed comparable effect size for both surgical procedures.
  
  
  
  This meta-analysis and systematic review of RCTs suggests that fewer early major and minor complications are associated with LVSG compared with LRYGB procedure. However, this does not translate into higher readmission rate, reoperation rate, or 30-day mortality for either procedure.
authors.affiliation: Department of Nutrition and Dietetics, Royal Brisbane and Women's Hospital, Herston, QLD, 4029, Australia.
authors.forename: Emma
authors.initials: E
authors.lastname: Osland
authors.affiliation: Institute of Mathematical Sciences, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Rossita Mohamad
authors.initials: RM
authors.lastname: Yunus
authors.affiliation: School of Agricultural, Computational and Environmental Sciences, International Centre for Applied Climate Sciences and Centre for Health Sciences Research, University of Southern Queensland, Toowoomba, QLD, Australia.
authors.forename: Shahjahan
authors.initials: S
authors.lastname: Khan
authors.affiliation: Department of Basic Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Tareq
authors.initials: T
authors.lastname: Alodat
authors.affiliation: Sunnybank Obesity Centre and South East Queensland Surgery (SEQS), Suite 9, McCullough Centre, 259 McCullough Street, Sunnybank, QLD, Australia.
authors.forename: Breda
authors.initials: B
authors.lastname: Memon
authors.affiliation: School of Agricultural, Computational and Environmental Sciences, International Centre for Applied Climate Sciences and Centre for Health Sciences Research, University of Southern Queensland, Toowoomba, QLD, Australia. mmemon@yahoo.com.|Sunnybank Obesity Centre and South East Queensland Surgery (SEQS), Suite 9, McCullough Centre, 259 McCullough Street, Sunnybank, QLD, Australia. mmemon@yahoo.com.|Mayne Medical School, School of Medicine, University of Queensland, Brisbane, QLD, Australia. mmemon@yahoo.com.|Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, Australia. mmemon@yahoo.com.|Faculty of Health and Social Science, Bolton University, Bolton, Lancashire, UK. mmemon@yahoo.com.
authors.forename: Muhammed Ashraf
authors.initials: MA
authors.lastname: Memon
mesh_terms: D002908:Chronic Disease / Q000628:therapy; D005743:Gastrectomy / Q000009:adverse effects*; D015390:Gastric Bypass / Q000009:adverse effects*; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D009765:Obesity / Q000150:complications / Q000601:surgery*; D011183:Postoperative Complications / Q000628:therapy; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors
keywords: Bariatric surgery; Laparoscopic; Meta-analysis; Roux-en-Y gastric bypass; Sleeve gastrectomy; Systematic review