title: Is galectin-3 associated with urinary albumin excretion in type 2 diabetes?
abstract: BACKGROUND
  The relationship between galectin-3 and diabetes mellitus or renal function has recently been investigated. In this study, we tried to evaluate the association of galectin-3 in urinary albumin excretion levels in type 2 diabetic patients.
  
  
  METHODS
  In a group of 137 type 2 diabetes patients, the mean of the last three urinary microalbumin/creatinine ratios and galectin-3 levels were evaluated. The patient group was divided into three subgroups according to their level of albuminuria calculated with urine microalbumin/creatinine ratio.
  
  
  RESULTS
  There was no significant difference between the galectin values of the three subgroups. Significant differences were observed between GFR results of group 1 vs. 3 (p < 0.0001) and group 2 vs. 3 (p = 0.0006), and serum creatinine results of group 1 vs. 3 (p = 0.0003) and group 2 vs. 3 (p < 0.0001). The three subgroups did not reveal any significant difference concerning the age, BMI, duration of DM, FPG, and HbA1c levels.
  
  
  CONCLUSIONS
  We concluded that serum galectin-3 values are not affected by the levels of urinary albumin excretion in DM patients. We could not find any relation between galectin-3 and the parameters of DM such as FPG, HbA1c, and duration of the disease. (Endokrynol Pol 2016; 67 (6): 580-584).
authors.affiliation: Dr. Lütfi Kırdar Kartal EAH, Biochemistry Department, Turkey. yucel.nihal@yahoo.com.
authors.forename: Nihal
authors.initials: N
authors.lastname: Yücel
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Çakır Madenci
authors.forename: Aycan
authors.initials: A
authors.lastname: Bölük
authors.forename: Lale
authors.initials: L
authors.lastname: Köroğlu Dağdelen
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Temel
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sargın
authors.forename: Asuman
authors.initials: A
authors.lastname: Orçun
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000097:blood* / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003928:Diabetic Nephropathies / Q000097:blood* / Q000209:etiology; D005260:Female; D037502:Galectin 3 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D037502:Galectin 3
keywords: galectin-3; nephropathy; type 2 diabetes mellitus