title: Reactive Oxygen Species (ROS) Responsive Polymers for Biomedical Applications.
abstract: Reactive oxygen species (ROS) play important roles in cell signaling pathways, while increased production of ROS may disrupt cellular homeostasis, giving rise to oxidative stress and a series of diseases. Utilizing these cell-generated species as triggers for selective tuning polymer structures and properties represents a promising methodology for disease diagnosis and treatment. Recently, significant progress has been made in fabricating biomaterials including nanoparticles and macroscopic networks to interact with this dynamic physiological condition. These ROS-responsive platforms have shown potential in a range of biomedical applications, such as cancer targeted drug delivery systems, cell therapy platforms for inflammation related disease, and so on.
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.|University of Chinese Academy of Sciences, Beijing, 100039, P. R. China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
authors.forename: Chaoliang
authors.initials: C
authors.lastname: He
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy*; D018384:Oxidative Stress; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000737:chemistry*; D015398:Signal Transduction
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D017382:Reactive Oxygen Species
keywords: ROS responsive polymer; biomedical application; oxidation-responsive material; stimuli-responsive polymer