title: [Clinical study of the influence of laryngopharyngeal reflux on quality of life in patients with dysphonia].
abstract: OBJECTIVE
  To explore the morbidity of laryngopharyngeal reflux in patients with dysphonic diseases and to investigate the influence of LPR on the patients.
  
  
  METHODS
  One hundred and twenty-seven patients with dysphonic diseases were encountered in Peking University of the People Hospital. Under the agreement, the patients were asked to fill in the scales of RSI, RFS, VHI and SF-36.24-hour ambulatory double pH monitoring was applied to diagnose LPR definitely. 2643 volunteers were recruited to fill in the RSI scale through physical examination, outpatient, the ward and web survey.
  
  
  RESULTS
  46.46% (59/127) patients were diagnosed with LPR definitely. 1241 of 2643 volunteer, who filled in the RSI, score more than zero in the first entry of hoarseness or dysphonia, 65.0% (807/1241) of them, scoring 13 points or higher, were diagnosed with clinically suspected LPR. Based on the 24-hour ambulatory double pH monitoring, VHI total scores and subscores in the emotional domains were higher in positive group than in negative group. There was no statistical difference (P>0.05) in functional and physical domains. The SF-36 scale was used to evaluate the quality of life of the patients. The difference of 6 dimensionality, scores had statistical significance (P<0.05), including role-physical, general health, validity, social function, role-emotional and mental health. There was no statistical difference in dimensionalities of role-physical and bodily pain.
  
  
  CONCLUSIONS
  The volunteers who were diagnosed with hoarseness or dysphonia had the higher morbidity rate of LPR. At the time of treatment, more attention should be paid to the quality of life.
authors.affiliation: Department of Otorhinolaryngology, Peking University People Hospital, Beijing 100044, China.
authors.forename: Yuguang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Email: lihongzhang@vip.sina.com.
authors.forename: Lihong
authors.initials: L
authors.lastname: Zhang
authors.forename: Lisheng
authors.initials: L
authors.lastname: Yu
authors.forename: Jingjing
authors.initials: J
authors.lastname: Li
authors.forename: Jinrang
authors.initials: J
authors.lastname: Li
authors.forename: Yixin
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Cao
mesh_terms: D055154:Dysphonia / Q000503:physiopathology*; D050782:Esophageal pH Monitoring; D006685:Hoarseness / Q000503:physiopathology; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000503:physiopathology*; D011788:Quality of Life; D011795:Surveys and Questionnaires