title: A new immunohistochemistry prognostic score (IPS) for recurrence and survival in resected pancreatic neuroendocrine tumors (PanNET).
abstract: Pancreatic neuroendocrine tumor (PanNET) is a neoplastic entity in which few prognostic factors are well-known. Here, we aimed to evaluate the prognostic significance of N-myc downstream-regulated gen-1 (NDRG-1), O6-methylguanine DNA methyltransferase (MGMT) and Pleckstrin homology-like domain family A member 3 (PHLDA-3) by immunohistochemistry (IHC) and methylation analysis in 92 patients with resected PanNET and follow-up longer than 24 months. In multivariate analyses, ki-67 and our immunohistochemistry prognostic score (IPS-based on MGMT, NDRG-1 and PHLDA-3 IHC expression) were independent prognostic factors for disease-free-survival (DFS), while age and IPS were independent prognostic factors for overall survival (OS). Our IPS could be a useful prognostic biomarker for recurrence and survival in patients following resection for PanNET.
authors.affiliation: Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.|Department of Medical Oncology, Complejo Hospitalario de Navarra-Instituto de Investigaciones Sanitarias de Navarra-IDISNA, Pamplona, Navarra, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Viúdez
authors.affiliation: Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: Filipe L F
authors.initials: FL
authors.lastname: Carvalho
authors.affiliation: Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Maleki
authors.affiliation: The Division of Biostatistics and Bioinformatics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Marianna
authors.initials: M
authors.lastname: Zahurak
authors.affiliation: Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Laheru
authors.affiliation: Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Stark
authors.affiliation: Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: Nilofer S
authors.initials: NS
authors.lastname: Azad
authors.affiliation: Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Wolfgang
authors.affiliation: Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Baylin
authors.affiliation: Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: James G
authors.initials: JG
authors.lastname: Herman
authors.affiliation: Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: Ana
authors.initials: A
authors.lastname: De Jesus-Acosta
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D018797:Cell Cycle Proteins / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D045643:DNA Repair Enzymes / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D047908:Intracellular Signaling Peptides and Proteins / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000401:mortality / Q000473:pathology*; D009687:Nuclear Proteins / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D025521:Tumor Suppressor Proteins / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D000099259:N-myc Downstream-Regulated Gene 1 Protein
chemical_list: D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D015254:DNA Modification Methylases; D045643:DNA Repair Enzymes; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D025521:Tumor Suppressor Proteins; D000099259:N-myc Downstream-Regulated Gene 1 Protein; C109277:TSSC3 protein; C515491:MGMT protein, human
keywords: MGMT; NDRG-1; PHLDA-3; Pathology Section; immunohistochemistry; pancreatic neuroendocrine tumor