title: [Expression and significance of HGAL and LMO2 in follicular lymphoma].
abstract: OBJECTIVE
  To evaluate the diagnostic value of HGAL and LMO2 expression and compare with CD10 and bcl-6 in follicular lymphoma (FL).
  
  
  METHODS
  63 cases of FL were collected from Guangdong General Hospital. The expression of HGAL, LMO2, CD10 and bcl-6 was assessed by immunohistochemistry.
  
  
  RESULTS
  The expression rates of HGAL, LMO2, CD10 and bcl-6 were 98.4% (62/63), 82.5% (52/63), 82.5% (52/63) and 87.3% (55/63), respectively. The expression rate of HGAL was higher than those of LMO2, CD10 and bcl-6, but the differences were not significant (P>0.05). There was no significant difference in HGAL, LMO2 and bcl-6 expression among FL1, FL2 and FL3 cases. The CD10 expression rate of FL1-3A cases was significantly higher than that of FL3B cases(P<0.01).
  
  
  CONCLUSIONS
  HGAL and LMO2, especially HGAL, can be used in FL particularly high grade FL as useful germinal center marker.
authors.affiliation: Department of Pathology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Zhang
authors.forename: Donglan
authors.initials: D
authors.lastname: Luo
authors.forename: Xinlan
authors.initials: X
authors.lastname: Luo
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Hengguo
authors.initials: H
authors.lastname: Zhuang
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Liu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018858:Germinal Center; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins / Q000378:metabolism*; D008224:Lymphoma, Follicular / Q000378:metabolism*; D008840:Microfilament Proteins; D009363:Neoplasm Proteins / Q000378:metabolism*; D015260:Neprilysin / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; C476824:GCSAM protein, human; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; C085117:LMO2 protein, human; D008840:Microfilament Proteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; D015260:Neprilysin