title: Iridoid Glucosides and Diterpenoids from Caryopteris glutinosa.
abstract: Five new iridoid glucoside derivatives (1-5), three new diterpenoids (7, 12, and 15), and 11 known compounds were isolated from the aqueous EtOH extract of Caryopteris glutinosa. Cell-based estrogen biosynthesis assays indicated that caryopteriside C (3) and caryopterisoid B (12) promote the biosynthesis of estrogen E2, with EC50 values of 11.1 and 8.0 μM, respectively, in human ovarian granulosa-like KGN cells via upregulating the expression of aromatase.
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, People's Republic of China.|University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.|Guiyang College of Traditional Chinese Medicine , Guiyang 550025, People's Republic of China.
authors.forename: Guoyong
authors.initials: G
authors.lastname: Luo
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Ye
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, People's Republic of China.
authors.forename: Baowen
authors.initials: B
authors.lastname: Du
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, People's Republic of China.
authors.forename: Guo-Lin
authors.initials: GL
authors.lastname: Zhang
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, People's Republic of China.
authors.forename: Yinggang
authors.initials: Y
authors.lastname: Luo
mesh_terms: D001141:Aromatase; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D057888:Iridoid Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D004224:Diterpenes; D004967:Estrogens; D057888:Iridoid Glucosides; D001141:Aromatase; C561410:CYP19A1 protein, human