title: tRNA fragments: novel players in intergenerational inheritance.
abstract: Non-genetic inheritance is an evocative topic; in the past few years, the debate around potential inheritance of life-time experiences independent of social factors in mammals has become highly prominent due to increasing evidence for phenotypes in the offspring after paternal environmental exposures. Strikingly, two independent studies published in Science newly implicate a special class of RNA, transfer RNA fragments, in the intergenerational effects of paternal dietary intervention.
authors.affiliation: The Gurdon Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.|The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
authors.forename: Katharina
authors.initials: K
authors.lastname: Gapp
authors.affiliation: The Gurdon Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.|The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Miska
mesh_terms: D000818:Animals; D059305:Diet, High-Fat; D018753:Diet, Protein-Restricted; D044127:Epigenesis, Genetic; D051379:Mice; D000072740:Paternal Inheritance; D010641:Phenotype; D012343:RNA, Transfer / Q000502:physiology*; D018626:Retroelements
chemical_list: D018626:Retroelements; D012343:RNA, Transfer