title: Multifunctional Antioxidants: Regenerable Radical-Trapping and Hydroperoxide-Decomposing Ebselenols.
abstract: Regenerable, multifunctional ebselenol antioxidants were prepared that could quench peroxyl radicals more efficiently than α-tocopherol. These compounds act as better mimics of the glutathione peroxidase enzymes than ebselen. Production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in human mononuclear cells was considerably decreased upon exposure to the organoselenium compounds. At a concentration of 25 μm, the ebselenol derivatives showed minimal toxicity in pre-osteoblast MC3T3 cells.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research (IISER), Bhopal-, 462066, India.
authors.forename: Shailesh
authors.identifier: http://orcid.org/0000-0001-6221-4512
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Chemistry-BMC, Uppsala University, Box-576, 75123, Uppsala, Sweden.
authors.forename: Jiajie
authors.identifier: http://orcid.org/0000-0003-0689-3180
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Chemistry-BMC, Uppsala University, Box-576, 75123, Uppsala, Sweden.
authors.forename: Jia-Fei
authors.identifier: http://orcid.org/0000-0002-5568-7415
authors.initials: JF
authors.lastname: Poon
authors.affiliation: Department of Chemistry-BMC, Uppsala University, Box-576, 75123, Uppsala, Sweden.
authors.forename: Vijay P
authors.identifier: http://orcid.org/0000-0002-5584-2067
authors.initials: VP
authors.lastname: Singh
authors.affiliation: Division of Applied Materials Science, Department of Engineering Sciences, Uppsala University, Sweden.
authors.forename: Xi
authors.initials: X
authors.lastname: Lu
authors.affiliation: Division of Applied Materials Science, Department of Engineering Sciences, Uppsala University, Sweden.
authors.forename: Marjam
authors.initials: M
authors.lastname: Karlsson Ott
authors.affiliation: Department of Chemistry-BMC, Uppsala University, Box-576, 75123, Uppsala, Sweden. lars.engman@kemi.uu.se.
authors.forename: Lars
authors.identifier: http://orcid.org/0000-0001-7751-629X
authors.initials: L
authors.lastname: Engman
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research (IISER), Bhopal-, 462066, India. sangitkumar@iiserb.ac.in.
authors.forename: Sangit
authors.identifier: http://orcid.org/0000-0003-0658-8709
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D001393:Azoles / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry*; D054833:Isoindoles; D016566:Organoselenium Compounds / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001393:Azoles; D005609:Free Radicals; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen; D006861:Hydrogen Peroxide
keywords: antioxidants; ascorbic acid; cytotoxicity; ebselen; selenium