title: Intraoperative aberrometry-based aphakia refraction in patients with cataract: status and options.
abstract: To explore the application of intraoperative wavefront aberrometry (IWA) for aphakia-based biometry using three existing formulae derived from autorefractive retinoscopy and introducing new improved formulae.
  
  
  
  In 74 patients undergoing cataract surgery, three repeated measurements of aphakic spherical equivalent (SE) were taken. All measurements were objectively graded for their quality and evaluated with the 'limits of agreement' approach. ORs were calculated and analysis of variance was applied. The intraocular lens (IOL) power that would have given the target refraction was back-calculated from manifest refraction at 3 months postoperatively. Regression analysis was performed to generate two aphakic SE-based formulae for predicting this IOL. The accuracy of the formulae was determined by comparing them to conventional biometry and published aphakia formulae.
  
  
  
  In 32 eyes, three consecutive aphakic measurements were successful. Objective parameters of IWA map quality significantly impacted measurement variability (p<0.05). The limits of agreement of repeated aphakic SE readings were +0.66 dioptre (D) and -0.69 D. Intraoperative biometry by our formula resulted in 25% and 53% of all cases ±0.50D and ±1.00 D within SE target, respectively. A second formula that took axial length (AL) into account resulted in improved ratios of 41% and 70%, respectively.
  
  
  
  A reliable application of IWA to calculate IOL power during routine cataract surgery may not be feasible given the high rate of measurement failures and the large variations of the readings. To enable reliable IOL calculation from IWA, measurement precision must be improved and aphakic IOL formulae need to be fine-tuned.
authors.affiliation: Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.|Ophthalmology Residency Rotation, South West Peninsula Postgraduate Medical Education, Plymouth, UK.
authors.forename: Jan O
authors.initials: JO
authors.lastname: Huelle
authors.affiliation: Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
authors.forename: Vasyl
authors.initials: V
authors.lastname: Druchkiv
authors.affiliation: Ophthalmology Residency Rotation, South West Peninsula Postgraduate Medical Education, Plymouth, UK.
authors.forename: Nabil E
authors.initials: NE
authors.lastname: Habib
authors.affiliation: Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
authors.forename: Gisbert
authors.initials: G
authors.lastname: Richard
authors.affiliation: Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.|Care Vision, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Toam
authors.initials: T
authors.lastname: Katz
authors.affiliation: Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.|Care Vision, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.|zentrumsehstärke, Hamburg, Germany.
authors.forename: Stephan J
authors.initials: SJ
authors.lastname: Linke
mesh_terms: D057128:Aberrometry / Q000379:methods*; D000328:Adult; D000368:Aged; D001035:Aphakia / Q000503:physiopathology*; D001699:Biometry / Q000379:methods*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology*; D012044:Regression Analysis
keywords: Clinical Trial; Optics and Refraction