title: The effect of teicoplanin on fracture healing: an experimental study.
abstract: OBJECTIVE
  This study aims to investigate the effect of teicoplanin on fracture healing stereologically and histopatologically.
  
  
  METHODS
  Twenty male Wistar albino rats were separated into two as the study (teicoplanin) and control groups. After intramedullary fixation of the right tibia of all the rats with 0.5 mm Kirschner wire under general anesthesia, standard closed shaft fractures were created using fracture formation apparatus. Teicoplanin (10 mg/kg) and saline were administered intraperitoneally to the study and control groups, respectively. Control radiographs were taken at the end of the procedure and the rats were sacrificed after 28 days. New bone and connective tissue volumes were calculated on obtained tissue samples using unbiased stereological and histopathological techniques.
  
  
  RESULTS
  It was observed that teicoplanin increased the formation of bone, vascularization, and connective tissue. There was a statistically significant difference between the two groups in respect of bone and vascular total volume (p<0.05). Although an increase was observed in connective tissue total volume, no statistically significant difference was detected between the two groups (p>0.05).
  
  
  CONCLUSIONS
  In addition to its antibacterial effect, teicoplanin may increase new bone formation; thus, it may be used safely in the treatment of bone defects accompanied with infection.
authors.affiliation: Department of Orthopedics and Traumatology, Medical Faculty of Ondokuz Mayıs University, 55139 Kurupelit, Samsun, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Göçer
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Önger
authors.forename: Numan
authors.initials: N
authors.lastname: Kuyubaşı
authors.forename: Alper
authors.initials: A
authors.lastname: Çıraklı
authors.forename: Mustafa Çağlar
authors.initials: MÇ
authors.lastname: Kır
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects; D005594:Fracture Fixation, Intramedullary / Q000379:methods*; D017102:Fracture Healing / Q000187:drug effects*; D005596:Fractures, Closed / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D008297:Male; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D017334:Teicoplanin / Q000494:pharmacology*; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin