title: Role of proton receptor OGR1 in bone response to metabolic acidosis?
abstract: Chronic metabolic acidosis stimulates bone resorption, resulting in loss of calcium and bicarbonate from bone. Both osteoblasts and osteoclasts sense extracellular H(+) by the G-protein coupled receptor, OGR1, whose activation leads to increased bone resorption as well as decreased bone formation. Krieger et al. examined the effect of OGR1 knockout in mice. They found an unexpected increase in bone resorption, but nevertheless an increase in bone volume linked to enhanced bone formation. This discovery opens a window of opportunity to explore potential new anabolic treatments for patients with low bone mass.
authors.affiliation: Department of Internal Medicine, Nephrology Division, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Vanda
authors.initials: V
authors.lastname: Jorgetti
authors.affiliation: Inserm Unit 1018, Team 5, Centre de Recherche en Épidémiologie et Santé des Populations (CESP), Hôpital Paul Brousse, Paris-Sud University and Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University), Villejuif, France. Electronic address: tilman.drueke@inserm.fr.
authors.forename: Tilman B
authors.initials: TB
authors.lastname: Drüeke
authors.affiliation: Department of Medicine, University of Washington, Seattle, Washington, USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Ott
mesh_terms: D000138:Acidosis / Q000378:metabolism; D000818:Animals; D001862:Bone Resorption / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts; D011522:Protons
chemical_list: D011522:Protons