title: Too Much, Too Little or Just Enough: A Goldilocks Effect for IL-13 and Skin Barrier Regulation?
abstract: The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Hönzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.
authors.affiliation: Division of Immunology and Inflammation, Department of Medicine, Imperial College London, London, UK. Electronic address: j.strid@imperial.ac.uk.
authors.forename: Jessica
authors.initials: J
authors.lastname: Strid
authors.affiliation: Department of Dermatology and Genetic Medicine, School of Life Sciences, University of Dundee, Dundee, UK.
authors.forename: W H Irwin
authors.initials: WHI
authors.lastname: McLean
authors.affiliation: National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin, Ireland; Department of Paediatric Dermatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland; Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland. Electronic address: irvinea@tcd.ie.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Irvine
mesh_terms: D016207:Cytokines / Q000378:metabolism*; D003876:Dermatitis, Atopic / Q000276:immunology*; D000091344:Filaggrin Proteins; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D062725:Tight Junction Proteins / Q000378:metabolism*; D023083:beta-Defensins / Q000378:metabolism*
chemical_list: D016207:Cytokines; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D062725:Tight Junction Proteins; D023083:beta-Defensins