title: Paraoxonase-1 and arylesterase activities in patients with colorectal cancer.
abstract: BACKGROUND
  The aim of this study was to evaluate paraoxonase-1 (PON1) and arylesterase (ARE) activities and oxidative stress status in patients with colorectal carcinomas (CRC).
  
  
  METHODS
  Thirty-three patients (20 male, 13 female) with CRC and 30 healthy controls were enrolled in the study. Blood samples were obtained from the CRC patients before adjuvant therapy. Serum samples from CRC patients and healthy controls were analyzed for PON1 and ARE activities.
  
  
  RESULTS
  The PON1 and ARE activities of the patients with CRC were significantly higher compared to those of the control group (PON1 activity is 125.35±20.07 U/L for CRC patients and 1.22±0.48 U/L for control group, P<0.001; ARE activity is 160.76±10.79 U/L for CRC patients). ARE levels showed a positive correlation with smoking status (P=0.04). PON1 activity was higher in colon carcinoma patients (135.95±19.3 U/L) rather than rectal carcinoma patients (97.08±5.24 U/L) but it was not statistically significant (P=0.72).
  
  
  CONCLUSIONS
  Serum PON1 activity is increased in patients with CRC, and serum ARE levels showed a positive correlation with smoking status. PON1 activity was higher in colon carcinoma patients. There is no other study in literature investigating these activities for CRC patients. It should be reevaluated by larger clinical trials.
authors.affiliation: Department of Medical Oncology, Istanbul Education and Research Hospital Istanbul, Turkey.
authors.forename: Cigdem Usul
authors.initials: CU
authors.lastname: Afsar
authors.affiliation: Department of Medical Oncology, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
authors.forename: Meral
authors.initials: M
authors.lastname: Gunaldı
authors.affiliation: Department of Internal Medicine, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
authors.forename: Yıldız
authors.initials: Y
authors.lastname: Okuturlar
authors.affiliation: Department of Biochemistry, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
authors.forename: Asuman
authors.initials: A
authors.lastname: Gedikbası
authors.affiliation: Department of Radiation Oncology, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
authors.forename: Elif Eda
authors.initials: EE
authors.lastname: Tiken
authors.affiliation: Department of Pathology, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Kahraman
authors.affiliation: Department of Radiation Oncology, Adana Numune Training and Research Hospital Adana, Turkey.
authors.forename: Feryal
authors.initials: F
authors.lastname: Karaca
authors.affiliation: Department of Medical Oncology, Mersin Government Hospital Mersin, Turkey.
authors.forename: Vehbi
authors.initials: V
authors.lastname: Ercolak
authors.affiliation: Department of General Surgery, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karabulut
keywords: Colorectal cancer; arylesterase; paraoxonase