title: Influence of Thoracic Aortic Inflammation and Calcifications on Arterial Stiffness and Cardiac Function in Older Subjects.
abstract: BACKGROUND
  Vascular aging is accompanied by gradual remodeling affecting both arterial and cardiac structure and mechanical properties. Hypertension is suggested to exert pro-inflammatory actions enhancing arterial stiffness.
  
  
  OBJECTIVE
  To determine the influence of thoracic aortic inflammation and calcifications on arterial stiffness and cardiac function in hypertensive and normotensive older subjects.
  
  
  METHODS
  A prospective study.
  
  
  METHODS
  An acute geriatrics ward of the University Hospital of Nancy in France.
  
  
  METHODS
  Thirty individuals ≥ 65 years were examined, including 15 hypertensive subjects and 15 controls well-matched for age and sex.
  
  
  METHODS
  Applanation tonometry was used to measure aortic pulse wave velocity (AoPWV) and carotid/brachial pulse pressure amplification (PPA). Left ventricular parameters were measured with magnetic resonance imaging. Local thoracic aortic inflammation and calcification were measured by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography imaging. Biomarkers of low-grade inflammation were also quantified.
  
  
  RESULTS
  AoPWV was higher in elderly hypertensive subjects comparatively to normotensive controls (15.5±5.3 vs. 11.9±2.5, p=0.046), and hypertensives had a higher calcification volume. In the overall population, calcifications of the thoracic descending aorta and inflammation of the ascending aorta accounted for respectively 18.1% (p=0.01) and 9.6% (p=0.07) of AoPWV variation. Individuals with high levels of calcifications and/or inflammation had higher AoPWV (p=0.003). Inflammation had a negative effect on PPA explaining 13.8% of its variation (p<0.05).
  
  
  CONCLUSIONS
  This study highlights the importance of local ascending aortic inflammation as a potential major actor in the determination of PPA while calcifications and hypertension are more linked to AoPWV. Assessment of PPA in the very elderly could provide complementary information to improve diagnostic and therapeutic strategies targeting ascending aortic inflammation.
authors.affiliation: Laure Joly, MD, PhD; Department of Geriatrics; CHU-Nancy, 54511 Vandoeuvre les Nancy, France, Tel: +(33) 383 15 33 22; fax: +(33) 383 15 76 68; E-mail: l.joly@chu-nancy.fr.
authors.forename: L
authors.initials: L
authors.lastname: Joly
authors.forename: D
authors.initials: D
authors.lastname: Mandry
authors.forename: A
authors.initials: A
authors.lastname: Verger
authors.forename: C
authors.initials: C
authors.lastname: Labat
authors.forename: G
authors.initials: G
authors.lastname: Watfa
authors.forename: V
authors.initials: V
authors.lastname: Roux
authors.forename: G
authors.initials: G
authors.lastname: Karcher
authors.forename: P-Y
authors.initials: PY
authors.lastname: Marie
authors.forename: A
authors.initials: A
authors.lastname: Benetos
mesh_terms: D000368:Aged; D001011:Aorta / Q000473:pathology / Q000503:physiopathology; D001013:Aorta, Thoracic / Q000473:pathology* / Q000503:physiopathology*; D015415:Biomarkers; D001794:Blood Pressure; D002114:Calcinosis / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005602:France; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D007249:Inflammation / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers