title: Real-Time Hypoxia Prediction Using Decision Fusion.
abstract: Humans who operate in high altitudes for prolonged durations often suffer from hypoxia. The commencement of physiological and cognitive changes due to the onset of hypoxia may not be immediately apparent to the exposed individual. These changes can go unrecognized for minutes and even hours and may lead to serious performance degradation or complete incapacitation. A dynamic system capable of monitoring and detecting decreased physiologic states due to the onset of hypoxia has the potential to prevent adverse outcomes. In this study, we develop a real-time hypoxia monitoring system based on a parallel M -ary decision fusion architecture. Blood oxygen saturation levels and altitude readings are the inputs and estimates of the level of hypoxia are the outputs. We develop new temporal evolution models for blood oxygen saturation and functional impairment with respect to varying altitude. The proposed models enable accurate tracking of various hypoxia levels based on the duration of stay of the subject at an altitude. Using a Bayesian decision-making formulation, the system generates global estimates of the degree of hypoxia. The detection system is tested against synthetic and real datasets to demonstrate applicability and accuracy.
authors.forename: Sayandeep
authors.initials: S
authors.lastname: Acharya
authors.forename: Arjun
authors.initials: A
authors.lastname: Rajasekar
authors.forename: Barry S
authors.initials: BS
authors.lastname: Shender
authors.forename: Leonid
authors.initials: L
authors.lastname: Hrebien
authors.forename: Moshe
authors.initials: M
authors.lastname: Kam
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis*; D008297:Male; D008954:Models, Biological; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000097:blood*
chemical_list: D010100:Oxygen