title: Prediction of Certain Well-Characterized Domains of Known Functions within the PE and PPE Proteins of Mycobacteria.
abstract: The PE and PPE protein family are unique to mycobacteria. Though the complete genome sequences for over 500 M. tuberculosis strains and mycobacterial species are available, few PE and PPE proteins have been structurally and functionally characterized. We have therefore used bioinformatics tools to characterize the structure and function of these proteins. We selected representative members of the PE and PPE protein family by phylogeny analysis and using structure-based sequence annotation identified ten well-characterized protein domains of known function. Some of these domains were observed to be common to all mycobacterial species and some were species specific.
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad, 500046, India.
authors.forename: Rafiya
authors.initials: R
authors.lastname: Sultana
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad, 500046, India.
authors.forename: Karunakar
authors.initials: K
authors.lastname: Tanneeru
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad, 500046, India.
authors.forename: Ashwin B R
authors.initials: AB
authors.lastname: Kumar
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad, 500046, India.
authors.forename: Lalitha
authors.initials: L
authors.lastname: Guruprasad
mesh_terms: D020816:Amino Acid Motifs; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics*; D019295:Computational Biology; D016680:Genome, Bacterial; D008958:Models, Molecular; D008969:Molecular Sequence Data; D005810:Multigene Family; D009161:Mycobacterium / Q000145:classification / Q000235:genetics*; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D037521:Virulence Factors / Q000737:chemistry / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors