title: Structure Elucidation of Nigricanoside A Through Enantioselective Total Synthesis.
abstract: Nigricanoside A was isolated from green alga, and its dimethyl ester was found to display potent cytotoxicity. Its scarcity prevented a full structure elucidation, leaving total synthesis as the only means to determine its relative and absolute stereochemistry and to explore its biological activity. Here we assign the stereochemistry of the natural product through enantioselective total synthesis and provide initial studies of its cytotoxicity.
authors.affiliation: Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd. Dallas, TX USA 75390-9038.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd. Dallas, TX USA 75390-9038.
authors.forename: Panduka
authors.initials: P
authors.lastname: Koswatta
authors.affiliation: Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd. Dallas, TX USA 75390-9038.
authors.forename: J Robb
authors.initials: JR
authors.lastname: DeBergh
authors.affiliation: Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd. Dallas, TX USA 75390-9038.
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.affiliation: Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd. Dallas, TX USA 75390-9038.
authors.forename: Ende
authors.initials: E
authors.lastname: Pan
authors.affiliation: Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd. Dallas, TX USA 75390-9038.
authors.forename: John B
authors.initials: JB
authors.lastname: MacMillan
authors.affiliation: Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd. Dallas, TX USA 75390-9038.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Ready