title: The Spectrum of Recovery From Fracture-Induced Vertebral Deformity in Pediatric Leukemia.
abstract: Vertebral fractures (VF) are a frequent complication of acute lymphoblastic leukemia. Some children with VF undergo vertebral body reshaping to the point of complete restoration of normal vertebral dimensions. Others are left with permanent vertebral deformity if the degree of reshaping has been incomplete by the time of final adult height attainment. In this report, we describe three children with painful VF at leukemia diagnosis or during chemotherapy. Each patient highlights different clinical trajectories in their recovery from VF and underscores the need for osteoporosis intervention trials with the goal to prevent permanent vertebral deformity in selected patients.
authors.affiliation: Pediatric Bone Health Clinical Research Program, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.|Department of Clinical Medicine, Health Sciences Center, Federal University of Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Leo C
authors.initials: LC
authors.lastname: Dal Osto
authors.affiliation: Pediatric Bone Health Clinical Research Program, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Victor N
authors.initials: VN
authors.lastname: Konji
authors.affiliation: Department of Pediatrics, Division of Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Halton
authors.affiliation: Department of Medical Imaging, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Matzinger
authors.affiliation: Department of Pediatrics, Division of Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
authors.forename: Mylène
authors.initials: M
authors.lastname: Bassal
authors.affiliation: Shriners Hospital for Children and McGill University, Montreal, Quebec, Canada.
authors.forename: Frank
authors.initials: F
authors.lastname: Rauch
authors.affiliation: Pediatric Bone Health Clinical Research Program, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.|Department of Pediatrics, Division of Endocrinology and Metabolism, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
authors.forename: Leanne M
authors.initials: LM
authors.lastname: Ward
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010012:Osteogenesis / Q000502:physiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D011859:Radiography; D016103:Spinal Fractures / Q000000981:diagnostic imaging* / Q000209:etiology*
keywords: children; leukemia; vertebral body reshaping; vertebral fractures