title: Synchronous clear cell renal cell carcinoma and multilocular cystic renal cell neoplasia of low malignant potential: A clinico-pathologic and molecular study.
abstract: We report a rare case of synchronous clear cell renal cell carcinoma and multilocular cystic renal cell neoplasia of low malignant potential in the same kidney. The tumors were seen incidentally in a 45-year-old man. Pathologic study revealed that the former tumor was nucleolar grade 2, and the multilocular cystic renal cell neoplasia of low malignant potential was nucleolar grade 1. At immunohistochemistry, the clear cells in both tumors were positive for CD10 and CA IX. Interestingly, these uncommon synchronous tumors showed a different KRAS/NRAS mutation analysis that was characterized by KRAS mutation at codon p.G12C in the clear cell renal cell carcinoma, while this mutation was not present in the case of multilocular cystic renal cell neoplasia of low malignant potential. NRAS mutation was not seen in any of the tumors.
authors.affiliation: Histopathology and Molecular Diagnostics, Universital Hospital Careggi, Florence, Italy. Electronic address: mariarosaria.raspollini@aouc.unifi.it.
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Raspollini
authors.affiliation: Histopathology and Molecular Diagnostics, Universital Hospital Careggi, Florence, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Castiglione
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Section of Pathological Anatomy, Department of Biomedical Sciences and Public Health, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
authors.affiliation: Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain; Champalimaud Clinical Center, Lisbon, Portugal.
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez-Beltran
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism; D000071231:Carbonic Anhydrase IX / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D004252:DNA Mutational Analysis; D006801:Humans; D007150:Immunohistochemistry; D052177:Kidney Diseases, Cystic / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D007680:Kidney Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D015260:Neprilysin / Q000378:metabolism; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; C117307:KRAS protein, human; D015260:Neprilysin; D016283:Proto-Oncogene Proteins p21(ras); C089226:CA9 protein, human; D000071231:Carbonic Anhydrase IX
keywords: Clear cell renal cell carcinoma; KRAS; Kidney; Multilocular cystic clear cell renal cell neoplasm of low malignant potential; Synchronous