title: Liver Transplantation in Adults with Acute Liver Failure: A Single Center Experience over A Period of 15 Years.
abstract: OBJECTIVE
  Liver transplantation (LT) is an effective treatment modality for acute liver failure (ALF). However, no reports have examined a large number of patients who underwent adult living donor LT (LDLT) for ALF.
  
  
  METHODS
  Seventy-four adult patients who underwent LT including 72 LDLT in a single center over a period of 15 years were reviewed.
  
  
  RESULTS
  Of 74 cases, there were 17 cases with acute type ALF and 57 cases with subacute type of ALF. Etiologies of hepatitis were hepatitis B virus in 31 cases, drug exposure in 11 cases, autoimmune hepatitis in two cases, and unknown in 30 cases. Patient survival was 65%, 65%, and 61% at 1, 3, and 5 years, respectively. The overall survival rates did not differ among patients divided by etiology of ALE (p = 0.693), type of ALE (p 0.745), ABD compatibility (p a, 0.912), total scores for predictive variables (p = 0.975), or graft-to-recipient weight ratio greater or less than 0.8% (p = 0.063). The most frequent cause of death within 1 month aftet LT was infection.
  
  
  CONCLUSIONS
  LT produces favorable outcomes in adult patients with ALE irrespective of etiology, type of ALE, or pre-transpiant liver conditions.
authors.forename: Toshimi
authors.initials: T
authors.lastname: Kaido
authors.forename: Kohei
authors.initials: K
authors.lastname: Ogawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ogura
authors.forename: Koichiro
authors.initials: K
authors.lastname: Hata
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yoshizawa
authors.forename: Shintaro
authors.initials: S
authors.lastname: Yagi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ito
authors.forename: Shinji
authors.initials: S
authors.lastname: Uemoto
mesh_terms: D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications*; D015331:Cohort Studies; D005260:Female; D006509:Hepatitis B / Q000150:complications*; D019693:Hepatitis, Autoimmune / Q000150:complications; D006801:Humans; D017114:Liver Failure, Acute / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult