title: Cross-validation of oxygen uptake prediction during walking in ambulatory persons with multiple sclerosis.
abstract: BACKGROUND
  An equation for predicting the gross oxygen uptake (gross-VO2) during walking for persons with multiple sclerosis (MS) has been developed. Predictors included walking speed and total score from the 12-Item Multiple Sclerosis Walking Scale (MSWS-12).
  
  
  OBJECTIVE
  This study examined the validity of this prediction equation in another sample of persons with MS.
  
  
  METHODS
  Participants were 18 persons with MS with limited mobility problems (42 ± 13 years; 14 women). Participants completed the MSWS-12. Gross-VO2 was measured with open-circuit spirometry during treadmill walking at 2.0, 3.0, and 4.0 mph (0.89, 1.34, and 1.79 m·s(-1)).
  
  
  RESULTS
  Absolute percent error was small: 8.3 ± 6.1% , 8.0 ± 5.6% , and 12.2 ± 9.0% at 2.0, 3.0, and 4.0 mph, respectively. Actual gross-VO2 did not differ significantly from predicted gross-VO2 at 2.0 and 3.0 mph, but was significantly higher than predicted gross-VO2 at 4.0 mph (p <  0.001). Bland-Altman plots indicated nearly zero mean difference between actual and predicted gross-VO2 with modest 95% confidence intervals at 2.0 and 3.0 mph, but there was some underestimation at 4.0 mph.
  
  
  CONCLUSIONS
  Speed and MSWS-12 score provide valid prediction of gross-VO2 during treadmill walking at slow and moderate speeds in ambulatory persons with MS. However, there is a possibility of small underestimation for walking at 4.0 mph.
authors.affiliation: Department of Kinesiology, Mississippi State University, Mississippi State, MS, USA.
authors.forename: Stamatis
authors.initials: S
authors.lastname: Agiovlasitis
authors.affiliation: Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Motl
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D015308:Anaerobic Threshold; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D009103:Multiple Sclerosis / Q000378:metabolism*; D010101:Oxygen Consumption; D012044:Regression Analysis; D015203:Reproducibility of Results; D013147:Spirometry; D016138:Walking; D055815:Young Adult
keywords: Energy expenditure; MSWS-12; disability; gait