title: [Association between oxytocin augmentation intervals and the risk of postpartum haemorrhage].
abstract: OBJECTIVE
  To study the association between the duration of oxytocin augmentation intervals and the risk of postpartum haemorrhage (PPH) among primiparous women in spontaneous labour.
  
  
  METHODS
  Retrospective cohort including primiparous women in spontaneous labour who received oxytocin during labour (n=454). Oxytocin augmentation intervals were dichotomized in intervals<20minutes and≥20minutes. Obstetrical and neonatal issues were analyzed according to the duration oxytocin augmentation intervals. The association between oxytocin augmentation intervals and PPH was analyzed using univariate and multivariate analysis.
  
  
  RESULTS
  Oxytocin augmentation intervals were shorter than 20minutes for 43.8% of the study population. The rate of PPH was higher (9.1% vs 3.5%; P=0.014), and the use of sulprostone was more frequent (6.5% vs 3.5%; P=0.013) if oxytocin augmentation intervals were shorter than 20minutes in comparison with intervals≥20minutes. The association between oxytocin augmentation intervals and PPH remains significant after adjustment on other PPH risk factors (adjusted OR=3.48, 95% CI [1.45-8.34]). The rate of adverse neonatal issue, defined by arterial pH at birth≤7.10 and/or 5minutes score d'Apgar≤7, was higher if oxytocin augmentation intervals were<20minutes (12.1% vs 4.3%; P=0.002).
  
  
  CONCLUSIONS
  Our study demonstrated an increased risk of PPH for primiparous women in spontaneous labour who received oxytocin with augmentation intervals shorter than 20minutes.
authors.affiliation: Maternité Port-Royal, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 53, avenue de l'Observatoire, 75014 Paris, France; École de sages-femmes Baudelocque, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 75014 Paris, France. Electronic address: clemence.loscul@cch.aphp.fr.
authors.forename: C
authors.initials: C
authors.lastname: Loscul
authors.affiliation: École de sages-femmes Baudelocque, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 75014 Paris, France; Inserm UMR 1153, équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), centre de recherche épidémiologie et statistique Sorbonne Paris Cité, DHU risques et grossesse, université Paris Descartes, 75014 Paris, France.
authors.forename: A-A
authors.initials: AA
authors.lastname: Chantry
authors.affiliation: Maternité Port-Royal, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 53, avenue de l'Observatoire, 75014 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Caubit
authors.affiliation: Inserm UMR 1153, équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), centre de recherche épidémiologie et statistique Sorbonne Paris Cité, DHU risques et grossesse, université Paris Descartes, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Deneux-Tharaux
authors.affiliation: Maternité Port-Royal, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 53, avenue de l'Observatoire, 75014 Paris, France; Inserm UMR 1153, équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), centre de recherche épidémiologie et statistique Sorbonne Paris Cité, DHU risques et grossesse, université Paris Descartes, 75014 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Goffinet
authors.affiliation: Maternité Port-Royal, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 53, avenue de l'Observatoire, 75014 Paris, France; Inserm UMR 1153, équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), centre de recherche épidémiologie et statistique Sorbonne Paris Cité, DHU risques et grossesse, université Paris Descartes, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Le Ray
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000187:drug effects*; D008875:Middle Aged; D010120:Oxytocics / Q000008:administration & dosage* / Q000009:adverse effects*; D010121:Oxytocin / Q000008:administration & dosage* / Q000009:adverse effects*; D006473:Postpartum Hemorrhage / Q000139:chemically induced*; D011247:Pregnancy; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D010120:Oxytocics; D010121:Oxytocin
keywords: Augmentation intervals; Hémorragie du post-partum; Intervalles d’augmentation; Oxytocin; Oxytocine; Postpartum haemorrhage