title: Placental Transfer of Perfluoroalkyl Substances and Associations with Thyroid Hormones: Beijing Prenatal Exposure Study.
abstract: Perfluoroalkyl substances (PFASs) have been detected in wildlife and human samples worldwide. Toxicology research showed that PFASs could interfere with thyroid hormone homeostasis. In this study, eight PFASs, fifteen PFAS precursors and five thyroid hormones were analyzed in 157 paired maternal and cord serum samples collected in Beijing around delivery. Seven PFASs and two precursors were detected in both maternal and cord sera with significant maternal-fetal correlations (r = 0.336 to 0.806, all P < 0.001). The median ratios of major PFASs concentrations in fetal versus maternal serum were from 0.25:1 (perfluorodecanoic acid, PFDA) to 0.65:1 (perfluorooctanoic acid, PFOA). Spearman partial correlation test showed that maternal thyroid stimulating hormone (TSH) was negatively correlated with most maternal PFASs (r = -0.261 to -0.170, all P < 0.05). Maternal triiodothyronin (T3) and free T3 (FT3) showed negative correlations with most fetal PFASs (r = -0.229 to -0.165 for T3; r = -0.293 to -0.169 for FT3, all P < 0.05). Our results suggest prenatal exposure of fetus to PFASs and potential associations between PFASs and thyroid hormone homeostasis in humans.
authors.affiliation: Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment, No. 7, Panjiayuannanli, 100021, Beijing, China.|State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment, No. 7, Panjiayuannanli, 100021, Beijing, China.
authors.forename: Jingguang
authors.initials: J
authors.lastname: Li
authors.affiliation: National Institute of Nutrition and Health, Chinese Centre for Disease Control and Prevention, China.
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Lai
authors.affiliation: State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.
authors.forename: Hemi
authors.initials: H
authors.lastname: Luan
authors.affiliation: State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.
authors.forename: Zongwei
authors.initials: Z
authors.lastname: Cai
authors.affiliation: Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment, No. 7, Panjiayuannanli, 100021, Beijing, China.
authors.forename: Yibaina
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment, No. 7, Panjiayuannanli, 100021, Beijing, China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment, No. 7, Panjiayuannanli, 100021, Beijing, China.
authors.forename: Yongning
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000328:Adult; D000068476:Beijing; D002210:Caprylates / Q000097:blood; D003652:Decanoic Acids / Q000097:blood; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005333:Fetus; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood* / Q000175:diagnosis; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D002210:Caprylates; D003652:Decanoic Acids; D004785:Environmental Pollutants; D005466:Fluorocarbons; D014284:Triiodothyronine; C036567:perfluorodecanoic acid; D013972:Thyrotropin; C023036:perfluorooctanoic acid; D013974:Thyroxine