title: Leptomeningeal transthyretin-type amyloidosis presenting as acute hydrocephalus and subarachnoid hemorrhage.
abstract: We present a report of a 47-year-old woman with developmental delay who presented with subarachnoid hemorrhage and acute hydrocephalus. She did not have an aneurysm, but there was symmetric calcification and gadolinium-enhancement of the meninges within the Sylvian fissure. Biopsy and genetic testing confirmed transthyretin-type amyloidosis. It is important to consider such rare causes in atypical presentations of non-aneurysmal subarachnoid hemorrhage.
authors.affiliation: Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, WACC 835, Boston, MA 02118, USA. Electronic address: mbevers@partners.org.
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Bevers
authors.affiliation: Department of Neuropathology, Massachusetts General Hospital, Boston, MA, USA; Office of the Chief Medical Examiner, New York, NY, USA.
authors.forename: Declan
authors.initials: D
authors.lastname: McGuone
authors.affiliation: Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, WACC 835, Boston, MA 02118, USA; Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
authors.forename: Nivedita U
authors.initials: NU
authors.lastname: Jerath
authors.affiliation: Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, WACC 835, Boston, MA 02118, USA.
authors.forename: Patricia L
authors.initials: PL
authors.lastname: Musolino
mesh_terms: D028227:Amyloid Neuropathies, Familial / Q000150:complications*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology*; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000209:etiology*
keywords: Amyloidosis; Subarachnoid hemorrhage; Transthyretin