title: Polycatechol nanosheet: a superior nanocarrier for highly effective chemo-photothermal synergistic therapy in vivo.
abstract: The integration of phototherapy and chemotherapy in a single system holds great promise to improve the therapeutic efficacy of tumor treatment, but it remains a key challenge. In this study, we describe our recent finding that polycatechol nanosheet (PCCNS) can be facilely prepared on a large scale via chemical polymerization at 4 °C, as an effective nanocarrier for loading high-density CuS nanocrystals as a photothermal agent. The resulting CuS/PCCNS nanocomposites exhibit good biocompatibility, strong stability, and a high photothermal conversion efficiency of ∼45.7%. The subsequent loading of anticancer drug doxorubicin (Dox) creates a superior theranostic agent with pH- and heat-responsive drug release, leading to almost complete destruction of mouse cervical tumor under NIR laser irradiation. This development offers an attractive theranostic agent for in vivo chemo-photothermal synergistic therapy toward biomedical applications.
authors.affiliation: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China. jiangxiue@ciac.ac.cn.
authors.forename: J
authors.initials: J
authors.lastname: Bai
authors.affiliation: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China. jiangxiue@ciac.ac.cn.
authors.forename: X D
authors.initials: XD
authors.lastname: Jia
authors.affiliation: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China. jiangxiue@ciac.ac.cn and Graduate School of the Chinese Academy of Sciences, Beijing 100039, China.
authors.forename: Z F
authors.initials: ZF
authors.lastname: Ma
authors.affiliation: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China. jiangxiue@ciac.ac.cn.
authors.forename: X E
authors.initials: XE
authors.lastname: Jiang
authors.affiliation: College of Chemistry, Sichuan University, Chengdu 610064, Sichuan, China. sunxp@ciac.ac.cn and Chemistry Department & Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: X P
authors.initials: XP
authors.lastname: Sun
mesh_terms: D000818:Animals; D002396:Catechols / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010789:Phototherapy / Q000379:methods*; D013440:Sulfides / Q000737:chemistry / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays
chemical_list: D002396:Catechols; D004337:Drug Carriers; D013440:Sulfides; D003300:Copper; D004317:Doxorubicin