title: [Research advances of K-ras mutation in the prognosis and targeted therapy of gastric cancer].
abstract: K-ras mutations have been described in 30% of human cancers with significantly different mutation frequencies. High K-ras mutation frequency is found in many cancers such as pancreas and lung cancers, whereas, gastric cancer has a relatively low K-ras mutation frequency. In recent years, numerous researches have focused on the K-ras mutation in gastric cancer. This review summarizes the K-ras mutation frequency in gastric cancer, the relationship of K-ras mutation with clinicopathologic features and prognosis of gastric cancer patients, targeted therapy for K-ras mutated gastric cancer, some small-molecular inhibitors of K-ras, and development of targeted therapy drugs for K-ras signaling pathway in gastric cancer.
authors.affiliation: Department of Oncology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University School of Medicine, Nanjing 210008, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Wei
authors.forename: B R
authors.initials: BR
authors.lastname: Liu
mesh_terms: D011905:Genes, ras; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics; D058990:Molecular Targeted Therapy; D009154:Mutation; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy