title: Enhanced anti-immobility effects of Sanggenon G isolated from the root bark of Morus alba combined with the α2-antagonist yohimbine in the rat forced swim test.
abstract: In this study, we aimed to determine whether Sanggenon G, an active compound isolated from the root bark of Morus alba, exhibited enhanced anti-immobility activity with the addition of the α2-antagonist yohimbine in rats subjected to forced swim test (FST)-induced depression. Fluoxetine (a selective serotonin reuptake inhibitor) treatment in rats reduced the immobility time, and pretreatment with yohimbine significantly enhanced the antidepressant-like behavior of fluoxetine at 5, 10 and 20 mg/kg. Similarly, Sanggenon G significantly decreased the immobility time, reducing immobility by a maximum of 43.9 % when treated at a dose of 20 mg/kg. Furthermore, pretreatment with yohimbine significantly enhanced the antidepressant-like behavior of Sanggenon G at 5 and 10 mg/kg. Our findings suggest that the antidepressant-like effect of Sanggenon G could be facilitated by concomitant use of the α2-antagonist. Further studies are needed to evaluate the potential of Sanggenon G as an alternative therapeutic approach for the treatment of depression.
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam, 463-746, Korea.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Lim
authors.affiliation: Graduate School of Biotechnology and Research Institute of Life Sciences and Resources, Kyung Hee University, Yongin, 446-701, Korea.
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam, 463-746, Korea.|Department of Food Biotechnology, Korea University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon, 305-333, Republic of Korea.
authors.forename: Yun Tai
authors.initials: YT
authors.lastname: Kim
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam, 463-746, Korea.
authors.forename: Changho
authors.initials: C
authors.lastname: Lee
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam, 463-746, Korea.
authors.forename: In-Ho
authors.initials: IH
authors.lastname: Kim
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam, 463-746, Korea. imissu@kfri.re.kr.
authors.forename: Daeseok
authors.initials: D
authors.lastname: Han
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000737:chemistry*; D002867:Chromones / Q000737:chemistry*; D003863:Depression / Q000188:drug therapy; D008297:Male; D031625:Morus / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013550:Swimming; D015016:Yohimbine / Q000627:therapeutic use*
chemical_list: D001572:Benzofurans; D002867:Chromones; C579694:sanggenon G; D015016:Yohimbine
keywords: Fluoxetine; Forced swim test; Sanggenon G; Yohimbine