title: Bentall Operation in a Patient With Severe Hemophilia A and Marfan Syndrome by Use of a Biologic Composite Graft.
abstract: We describe a patient with severe hemophilia A and Marfan syndrome who underwent an elective Bentall operation. Because of the severe hemophilia, anticoagulation could not be given postoperatively; thus, a biologic Valsalva conduit graft was used. During the procedure, factor VIII was given as a bolus dose just before incision, then by continous infusion intraoperatively to maintain the factor VIII activity level between 200% and 300%. Minimal postoperative bleeding occurred. The infusion was continued postoperatively at a lower dose until all chest tubes, pacing wires, and invasive catheters were removed. The patient was discharged on postoperative day 7 without adverse events.
authors.affiliation: Department of Cardiovascular Surgery, Celal Bayar University, Manisa, Turkey. Electronic address: fundanizamoglu@yahoo.com.
authors.forename: Funda
authors.initials: F
authors.lastname: Yildirim
authors.affiliation: Department of Cardiovascular Surgery, Celal Bayar University, Manisa, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Ozbakkaloglu
authors.affiliation: Department of Anesthesia and Reanimation, Celal Bayar University, Manisa, Turkey.
authors.forename: Tulun
authors.initials: T
authors.lastname: Ozturk
authors.affiliation: Department of Cardiovascular Surgery, Celal Bayar University, Manisa, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Tetik
mesh_terms: D000328:Adult; D001027:Aortography; D001688:Biological Products; D001807:Blood Vessel Prosthesis; D013504:Cardiovascular Surgical Procedures / Q000379:methods*; D017558:Elective Surgical Procedures / Q000379:methods*; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000150:complications / Q000601:surgery*; D011474:Prosthesis Design
chemical_list: D001688:Biological Products