title: Vemurafenib and concomitant stereotactic radiation for the treatment of melanoma with spinal metastases: A case report.
abstract: A 56-year-old man with BRAFV600E melanoma and spinal metastases treated with vemurafenib and stereotactic radiation showed a partial response without neurological, skin or mucosal toxicity, 8 months after completion of this combination. This case suggests that stereotactic radiation spares normal tissues and might be safer than conventional fractionated radiation with vemurafenib.
authors.affiliation: Department of Radiotherapy, François Baclesse Cancer Center, 3 Avenue General Harris, F-14000 Caen, France.
authors.forename: Dinu
authors.initials: D
authors.lastname: Stefan
authors.affiliation: Department of Radiotherapy, François Baclesse Cancer Center, 3 Avenue General Harris, F-14000 Caen, France.
authors.forename: Hosni
authors.initials: H
authors.lastname: Popotte
authors.affiliation: CHU-Caen, Dermatology, F-14033 Caen, France; Université-Caen-Basse-Normandie, Medical-School-Caen, F-14000, France.
authors.forename: Andreea Raluca
authors.initials: AR
authors.lastname: Stefan
authors.affiliation: CHU-Caen, Dermatology, F-14033 Caen, France; Université-Caen-Basse-Normandie, Medical-School-Caen, F-14000, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Tesniere
authors.affiliation: Department of Radiotherapy, François Baclesse Cancer Center, 3 Avenue General Harris, F-14000 Caen, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Tomaszewski
authors.affiliation: Department of Radiotherapy, François Baclesse Cancer Center, 3 Avenue General Harris, F-14000 Caen, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Lesueur
authors.affiliation: Department of Radiotherapy, François Baclesse Cancer Center, 3 Avenue General Harris, F-14000 Caen, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Habrand
authors.affiliation: CHU-Caen, Dermatology, F-14033 Caen, France; Université-Caen-Basse-Normandie, Medical-School-Caen, F-14000, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Verneuil
keywords: Melanoma metastasis; Stereotactic radiation; Vemurafenib