title: Association of systolic blood pressure levels with cardiovascular and cerebrovascular events and all-cause mortality: a result from the Kailuan study.
abstract: OBJECTIVE
  We aimed to examine the impact of different levels of systolic blood pressure (SBP) on the incidence of cardiovascular and cerebrovascular events and all-cause death in Chinese adults.
  
  
  METHODS
  A total of 97 013 Chinese men and women from the Kailuan study were followed up with the incidence of cardiovascular and cerebrovascular events and all-cause death. The participants were categorized into nine groups on the basis of the different SBP levels (mmHg) (groups 1-9): SBP<110, 110≤SBP<120, 120≤SBP<130, 130≤SBP<140, 140≤SBP<150, 150≤SBP<160, 160≤SBP<170, 170≤SBP<180, and SBP≥180. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated from Cox regression models.
  
  
  RESULTS
  During a mean follow-up of 4.02 years, a total of 2043 cardiovascular and cerebrovascular events and 1686 of all-cause deaths occurred. After adjustments for potential confounding factors and using group 1 as a reference, HRs (95% CIs) of total cardiovascular and cerebrovascular events for groups 2-9 were 1.35 (1.00-1.82), 1.61 (1.22-2.12), 1.54 (1.16-2.04), 2.05 (1.55-2.72), 2.47 (1.86-3.29), 3.04 (2.28-4.06), 3.93 (2.89-5.36), and 4.56 (3.39-6.15), respectively. HRs (95% CIs) of all-cause death for groups 2-9 were 0.92 (0.71-1.20), 0.95 (0.75-1.20), 1.06 (0.83-1.34), 1.18 (0.93-1.50), 1.16 (0.90-1.49), 1.39 (1.07-1.81), 1.74 (1.29-2.33), and 2.06 (1.56-2.72), respectively.
  
  
  CONCLUSIONS
  An increase in the SBP levels is significantly associated with an increased risk of cardiovascular and cerebrovascular events and all-cause death.
authors.affiliation: aGraduate School, Hebei Medical University, Shijiazhuang bDepartment of Cardiology, Kailuan Hospital, Hebei United University cDepartment of Cardiology, Tangshan People's Hospital, Tangshan, China.
authors.forename: Yuexia
authors.initials: Y
authors.lastname: Song
authors.forename: Shouling
authors.initials: S
authors.lastname: Wu
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Qi
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000401:mortality* / Q000503:physiopathology*; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged