title: Surface dynamics of voltage-gated ion channels.
abstract: Neurons encode information in fast changes of the membrane potential, and thus electrical membrane properties are critically important for the integration and processing of synaptic inputs by a neuron. These electrical properties are largely determined by ion channels embedded in the membrane. The distribution of most ion channels in the membrane is not spatially uniform: they undergo activity-driven changes in the range of minutes to days. Even in the range of milliseconds, the composition and topology of ion channels are not static but engage in highly dynamic processes including stochastic or activity-dependent transient association of the pore-forming and auxiliary subunits, lateral diffusion, as well as clustering of different channels. In this review we briefly discuss the potential impact of mobile sodium, calcium and potassium ion channels and the functional significance of this for individual neurons and neuronal networks.
authors.affiliation: a RG Molecular Physiology, Leibniz Institute for Neurobiology, Center for Behavioral Brain Science, Otto-von-Guericke-University of Magdeburg , Magdeburg , Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Heine
authors.affiliation: a RG Molecular Physiology, Leibniz Institute for Neurobiology, Center for Behavioral Brain Science, Otto-von-Guericke-University of Magdeburg , Magdeburg , Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Ciuraszkiewicz
authors.affiliation: b Lehrstuhl Systemverfahrenstechnik, Otto-von-Guericke-University of Magdeburg , Magdeburg , Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Voigt
authors.affiliation: a RG Molecular Physiology, Leibniz Institute for Neurobiology, Center for Behavioral Brain Science, Otto-von-Guericke-University of Magdeburg , Magdeburg , Germany.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Heck
authors.affiliation: a RG Molecular Physiology, Leibniz Institute for Neurobiology, Center for Behavioral Brain Science, Otto-von-Guericke-University of Magdeburg , Magdeburg , Germany.
authors.forename: Arthur
authors.initials: A
authors.lastname: Bikbaev
mesh_terms: D015220:Calcium Channels / Q000502:physiology*; D008564:Membrane Potentials; D009474:Neurons / Q000737:chemistry / Q000502:physiology*; D024642:Potassium Channels, Voltage-Gated / Q000502:physiology*; D013499:Surface Properties; D061566:Voltage-Gated Sodium Channels / Q000502:physiology*
chemical_list: D015220:Calcium Channels; D024642:Potassium Channels, Voltage-Gated; D061566:Voltage-Gated Sodium Channels
keywords: lateral diffusion; mobility; surface dynamics; voltage gated ion channels