title: Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1.
abstract: In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms.
authors.affiliation: Department of Infectious Diseases , Inselspital, Bern University Hospital, University of Bern.
authors.forename: C
authors.initials: C
authors.lastname: Béguelin
authors.affiliation: Department of Infectious Diseases , Inselspital, Bern University Hospital, University of Bern.
authors.forename: M
authors.initials: M
authors.lastname: Vázquez
authors.affiliation: Department of Neurology , Bern University Hospital and University of Bern.
authors.forename: M
authors.initials: M
authors.lastname: Bertschi
authors.affiliation: Laboratory of Virology , Geneva University Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Yerly
authors.affiliation: Department of Neurology , Bern University Hospital and University of Bern.
authors.forename: D
authors.initials: D
authors.lastname: de Jong
authors.affiliation: Department of Neurology , Bern University Hospital and University of Bern.
authors.forename: K
authors.initials: K
authors.lastname: Gutbrod
authors.affiliation: Department of Infectious Diseases , Inselspital, Bern University Hospital, University of Bern.
authors.forename: A
authors.initials: A
authors.lastname: Rauch
authors.affiliation: Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern; Infectious Diseases Unit, Cantonal Hospital, Chur, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Cusini
keywords: HIV; K65R; central nervous system; multidrug-resistant; viral escape