title: Charcot-marie-tooth disease type 1X in women: Electrodiagnostic findings.
abstract: Symptoms and signs in women with Charcot-Marie-Tooth disease type 1X (CMT1X) are often milder from those in men, but the available electrophysiologic evidence regarding CMT1X in women has been characterized in some patients as non-uniform or asymmetric.
  
  
  
  We retrospectively reviewed electrodiagnostic findings from 45 women and 31 men with CMT1X.
  
  
  
  Motor nerve conduction parameters in CMT1X women were less abnormal (P < 0.05), and a wider range of motor conduction velocities (CVs) were seen in women (P < 0.001) compared with men. In women, nerve conduction studies showed lack of conduction block without temporal dispersion. Motor CVs were more frequently in the normal range in women compared with men. There was no significant relationship to age of presentation and motor CV or compound muscle action potential in women.
  
  
  
  NCS parameters in CMT1X women did not demonstrate features suggestive of an acquired demyelinating neuropathy. Muscle Nerve, 2016 Muscle Nerve 54: -, 2016 Muscle Nerve 54: 728-732, 2016.
authors.affiliation: Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa, 52242, USA. nivedita-jerath@uiowa.edu.
authors.forename: Nivedita U
authors.initials: NU
authors.lastname: Jerath
authors.affiliation: Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa, 52242, USA.
authors.forename: Laurie
authors.initials: L
authors.lastname: Gutmann
authors.affiliation: Department of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
authors.forename: Chandan G
authors.initials: CG
authors.lastname: Reddy
authors.affiliation: Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa, 52242, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Shy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002607:Charcot-Marie-Tooth Disease / Q000175:diagnosis* / Q000503:physiopathology*; D002648:Child; D015331:Cohort Studies; D004568:Electrodiagnosis / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D012189:Retrospective Studies; D012737:Sex Factors; D055815:Young Adult
keywords: CMT1X; EDx; X-inactivation; nerve conduction studies; women