title: The relationship between erectile dysfunction and paroxysmal lone atrial fibrillation.
abstract: OBJECTIVE
  Endothelial dysfunction plays a major role in erectile dysfunction (ED). Atrial fibrillation (AF), regardless of subtype, is associated with a prothrombotic state, which is related to endothelial dysfunction. In this study, we aimed to determine whether AF is an independent risk factor for ED.
  
  
  METHODS
  A total of 50 patients diagnosed with paroxysmal lone AF and 80 age-, gender-, and body mass index-matched controls without AF who admitted to outpatient clinics at a tertiary center were enrolled. Diagnosis of ED was performed by using Sexual Health Inventory for Men (SHIM) questionnaire. Patients with a SHIM score ≤21 were defined as having ED.
  
  
  RESULTS
  Mean age of patients were 51.8 ± 7.7 and all of the study population were male. Twenty-nine of 50 patients in lone AF group and 25 of 80 patients in control group were diagnosed with ED (58 vs 31.2 %, p = 0.002). Mean SHIM score was significantly lower in lone AF group compared with controls (20.74 ± 2.67 vs 22.39 ± 2.21, p < 0.001). The multivariate stepwise logistic regression analyses showed that lone AF (OR 1.94 (1.44-2.46), p < 0.001), smoking (OR 1.92 (1.35-2.44), p = 0.003), fasting blood glucose (OR 1.51 (1.10-1.85), p = 0.012), and uric acid levels (OR 1.56 (1.13-1.92), p = 0.009) were independent predictors of ED.
  
  
  CONCLUSIONS
  Beat-to-beat variation may lead to ED in patients with paroxysmal lone AF and questioning erectile function in patients with lone AF may be recommended.
authors.affiliation: Cardiology Clinic, Yozgat State Hospital, Tekke Mah. Camlik Cad, 66200, Yozgat, Turkey. sametyilmazmd@gmail.com.
authors.forename: Samet
authors.initials: S
authors.lastname: Yılmaz
authors.affiliation: Cardiology Clinic, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, 06100, Turkey.
authors.forename: Mevlüt Serdar
authors.initials: MS
authors.lastname: Kuyumcu
authors.affiliation: Cardiology Clinic, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, 06100, Turkey.
authors.forename: Mehmet Kadri
authors.initials: MK
authors.lastname: Akboga
authors.affiliation: Cardiology Clinic, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, 06100, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Sen
authors.affiliation: Cardiology Clinic, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, 06100, Turkey.
authors.forename: Kevser Gülcihan
authors.initials: KG
authors.lastname: Balcı
authors.affiliation: Cardiology Clinic, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, 06100, Turkey.
authors.forename: Mustafa Mücahit
authors.initials: MM
authors.lastname: Balcı
authors.affiliation: Cardiology Clinic, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, 06100, Turkey.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Özeke
authors.affiliation: Cardiology Clinic, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, 06100, Turkey.
authors.forename: Dursun
authors.initials: D
authors.lastname: Aras
authors.affiliation: Cardiology Clinic, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, 06100, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Aydoğdu
mesh_terms: D001281:Atrial Fibrillation / Q000453:epidemiology*; D015984:Causality; D015897:Comorbidity; D007172:Erectile Dysfunction / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
keywords: Endothelial dysfunction; Erectile dysfunction; Paroxysmal atrial fibrillation