title: Socket Preservation Therapy with Acellular Dermal Matrix and Mineralized Bone Allograft After Tooth Extraction in Humans: A Clinical and Histomorphometric Study.
abstract: The aim of this study was to analyze through clinical and histomorphometric parameters the use of acellular dermal matrix (ADM) with or without mineralized bone allograft (AB) on bone formation in human alveoli after a 6- to 8-month healing period. A total of 19 patients in need of extraction of the maxillary anterior teeth were selected and randomly assigned to the test group (ADM plus AB) or to the control group (ADM only). Clinical and histomorphometric measurements and histologic analysis were recorded 6 to 8 months after ridge preservation procedures. Clinical parameters and amount of mineralized and nonmineralized tissue were measured and analyzed. In the clinical measurements, the test group showed reduced bone loss in the buccopalatal dimension after 6 to 8 months (intragroup analysis P < .01). Histologic findings showed higher percentages of mineralized tissue and lower percentages of nonmineralized tissue in the test group when compared with the control group (P < .05). In this randomized controlled clinical and histomorphometric study in humans, acellular dermal matrix in association with mineralized bone allograft reduced alveolar bone loss in the anterior maxillae both in height and width after a follow-up period of 6 to 8 months.
authors.forename: Patricia Garani
authors.initials: PG
authors.lastname: Fernandes
authors.forename: Valdir Antonio
authors.initials: VA
authors.lastname: Muglia
authors.forename: Danilo Maeda
authors.initials: DM
authors.lastname: Reino
authors.forename: Luciana Prado
authors.initials: LP
authors.lastname: Maia
authors.forename: Marcio Fernando
authors.initials: MF
authors.lastname: de Moraes Grisi
authors.forename: Sergio Luís
authors.initials: SL
authors.lastname: de Souza
authors.forename: Mario
authors.initials: M
authors.lastname: Taba
authors.forename: Daniela Bazan
authors.initials: DB
authors.lastname: Palioto
authors.forename: Adriana G
authors.initials: AG
authors.lastname: de Almeida
authors.forename: Arthur Belém
authors.initials: AB
authors.lastname: Novaes
mesh_terms: D062088:Acellular Dermis; D000328:Adult; D000368:Aged; D064591:Allografts; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D003094:Collagen; D005260:Female; D006801:Humans; D008297:Male; D008437:Maxilla; D008875:Middle Aged; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery*
chemical_list: C440568:Alloderm; D018786:Bone Substitutes; C000621423:MinerOss; D003094:Collagen