title: Differential Resting State Connectivity Patterns and Impaired Semantically Cued List Learning Test Performance in Early Course Remitted Major Depressive Disorder.
abstract: OBJECTIVE
  There is a well-known association between memory impairment and major depressive disorder (MDD). Additionally, recent studies are also showing resting-state functional magnetic resonance imaging (rsMRI) abnormalities in active and remitted MDD. However, no studies to date have examined both rs connectivity and memory performance in early course remitted MDD, nor the relationship between connectivity and semantically cued episodic memory.
  
  
  METHODS
  The rsMRI data from two 3.0 Tesla GE scanners were collected from 34 unmedicated young adults with remitted MDD (rMDD) and 23 healthy controls (HCs) between 18 and 23 years of age using bilateral seeds in the hippocampus. Participants also completed a semantically cued list-learning test, and their performance was correlated with hippocampal seed-based rsMRI. Regression models were also used to predict connectivity patterns from memory performance.
  
  
  RESULTS
  After correcting for sex, rMDD subjects performed worse than HCs on the total number of words recalled and recognized. rMDD demonstrated significant in-network hypoactivation between the hippocampus and multiple fronto-temporal regions, and multiple extra-network hyperconnectivities between the hippocampus and fronto-parietal regions when compared to HCs. Memory performance negatively predicted connectivity in HCs and positively predicted connectivity in rMDD. Conclusions Even when individuals with a history of MDD are no longer displaying active depressive symptoms, they continue to demonstrate worse memory performance, disruptions in hippocampal connectivity, and a differential relationship between episodic memory and hippocampal connectivity.
authors.affiliation: 1University of Illinois at Chicago,Department of Psychiatry,Chicago,Illinois.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Rao
authors.affiliation: 1University of Illinois at Chicago,Department of Psychiatry,Chicago,Illinois.
authors.forename: Lisanne M
authors.initials: LM
authors.lastname: Jenkins
authors.affiliation: 1University of Illinois at Chicago,Department of Psychiatry,Chicago,Illinois.
authors.forename: Erica
authors.initials: E
authors.lastname: Hymen
authors.affiliation: 1University of Illinois at Chicago,Department of Psychiatry,Chicago,Illinois.
authors.forename: Maia
authors.initials: M
authors.lastname: Feigon
authors.affiliation: 1University of Illinois at Chicago,Department of Psychiatry,Chicago,Illinois.
authors.forename: Sara L
authors.initials: SL
authors.lastname: Weisenbach
authors.affiliation: 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan.
authors.forename: Jon-Kar
authors.initials: JK
authors.lastname: Zubieta
authors.affiliation: 1University of Illinois at Chicago,Department of Psychiatry,Chicago,Illinois.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Langenecker
mesh_terms: D000293:Adolescent; D001245:Association Learning / Q000502:physiology; D003463:Cues; D003865:Major Depressive Disorder / Q000150:complications*; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007859:Learning Disabilities / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012146:Rest; D012660:Semantics; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Episodic memory; Functional connectivity; Hippocampus; Remitted MDD; Resting-state; fMRI