title: Ammonium tetrathiomolybdate as a water-soluble and slow-release hydrogen sulfide donor.
abstract: Ammonium tetrathiomolybdate (TTM) was found to be a slow hydrogen sulfide (H2S) releasing agent. Its H2S generation capability in aqueous solutions was confirmed by UV-vis and fluorescence assays. TTM also showed H2S-like cytoprotective effects in hydrogen peroxide (H2O2)-induced oxidative damage in HaCaT cells.
authors.affiliation: Department of Chemistry, Washington State University, Pullman, WA 99164, United States.
authors.forename: Shi
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Physiology, Guangzhou Medical University, Guangzhou 511436, China.
authors.forename: Chun-Tao
authors.initials: CT
authors.lastname: Yang
authors.affiliation: Department of Physiology, Guangzhou Medical University, Guangzhou 511436, China.
authors.forename: Fu-Hui
authors.initials: FH
authors.lastname: Meng
authors.affiliation: Department of Chemistry, Washington State University, Pullman, WA 99164, United States.
authors.forename: Armando
authors.initials: A
authors.lastname: Pacheco
authors.affiliation: Department of Physiology, Guangzhou Medical University, Guangzhou 511436, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Washington State University, Pullman, WA 99164, United States. Electronic address: mxian@wsu.edu.
authors.forename: Ming
authors.initials: M
authors.lastname: Xian
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D006862:Hydrogen Sulfide / Q000737:chemistry*; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry* / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D012995:Solubility / Q000187:drug effects; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water; D008982:Molybdenum; C020809:tetrathiomolybdate; D006861:Hydrogen Peroxide; D006862:Hydrogen Sulfide
keywords: Ammonium tetrathiomolybdate; Donor; Hydrogen sulfide; Oxidative damage