title: Antidiabetic Potential of Kefir Combination from Goat Milk and Soy Milk in Rats Induced with Streptozotocin-Nicotinamide.
abstract: The study aimed to evaluate the effect of kefir combination from goat milk and soy milk on lipid profile, plasma glucose, glutathione peroxidase (GPx) activity and the improvement of pancreatic β-cell in diabetic rats. Male rats were divided into five treatments: normal control, diabetic control, goat milk kefir, combination of goat milk-soy milk kefir and soy milk kefir. All rats were induced by streptooztocin-nicotinamide (STZ-NA), except for normal control. After 35 d experiment, the rats were sampled for blood, sacrificed and sampled for pancreatic tissues. Results showed that diabetic rats fed kefir combination had higher (p<0.05) triglyceride than the rats fed goat milk or soy milk kefir. Decreasing of plasma glucose in diabetic rats fed kefir combination was higher (p<0.05) than rats fed goat millk kefir. The activity of GPx in diabetic rats fed three kinds of kefir were higher (p<0.01) than untreated diabetic rats. The average number of Langerhans and β-cells in diabetic rats fed kefir combination was the same as the normal control, but it was higher than diabetic control. It was concluded that kefir combination can be used as antidiabetic through maintaining in serum triglyceride, decreasing in plasma glucose, increasing in GPx activity and improving in pancreatic β-cells.
authors.affiliation: Department of Animal Product Technology, Faculty of Animal Science,Universitas Gadjah Mada, Jl. Fauna 3, Kampus UGM, Bulaksumur, Yogyakarta 55281, Indonesia.
authors.lastname: Nurliyani
authors.affiliation: Faculty of Agricultural Technology, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
authors.forename: Eni
authors.initials: E
authors.lastname: Harmayani
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
authors.lastname: Sunarti
keywords: glutathione peroxidase; kefir combination; lipid profile; plasma glucose; β-cells