title: Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors.
abstract: Carboxy-terminal telopeptide of type I collagen (ICTP) is generated through matrix metalloproteinase (MMP)-dependent type I collagen digestion, and has been widely utilized as a biomarker for bone turnover. The fact that atherosclerotic lesions are rich in both type I collagen and MMP-producing macrophages led to the hypothesis that serum ICTP concentrations may serve as a non-invasive clinical biomarker for atherosclerosis. Therefore, the association of serum ICTP concentrations with the maximum intima-media thickness (IMT) of carotid arteries, a surrogate index of systemic atherosclerosis, or brachial-ankle pulse wave velocity (baPWV) in patients with atherosclerotic risk factors was evaluated. A total of 52 male and 65 female (mean age: 62.8 yrs) patients without renal failure, malignancies or bone diseases known to affect serum ICTP concentrations were recruited. Patients with max IMTs ≥1.1 mm showed significantly higher serum ICTP concentrations compared with patients with max IMTs <1.1 mm (3.33 ± 0.97 vs 2.82 ± 0.65 ng/mL, p<0.05). Serum ICTP concentration was also positively correlated with max IMT (p<0.001) or baPWV values (p<0.05). Multivariate analyses also revealed that serum ICTP concentrations were correlated with max IMT (p<0.001; 95% CI 0.200 to 0.454). These results suggest that serum ICTP concentrations can be used as a non-invasive biomarker for systemic atherosclerosis.
authors.affiliation: Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Itsuro
authors.initials: I
authors.lastname: Endo
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Aihara
authors.forename: Yukiyo
authors.initials: Y
authors.lastname: Onishi
authors.forename: Bingzi
authors.initials: B
authors.lastname: Dong
authors.forename: Yukari
authors.initials: Y
authors.lastname: Ohguro
authors.forename: Kiyoe
authors.initials: K
authors.lastname: Kurahashi
authors.forename: Sumiko
authors.initials: S
authors.lastname: Yoshida
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Fujinaka
authors.forename: Akio
authors.initials: A
authors.lastname: Kuroda
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Seiji
authors.initials: S
authors.lastname: Fukumoto
authors.forename: Toshio
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Abe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000097:blood* / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D024042:Collagen Type I / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D063177:Pulse Wave Analysis; D012307:Risk Factors
chemical_list: D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide