title: Learning intervention-induced deformations for non-rigid MR-CT registration and electrode localization in epilepsy patients.
abstract: This paper describes a framework for learning a statistical model of non-rigid deformations induced by interventional procedures. We make use of this learned model to perform constrained non-rigid registration of pre-procedural and post-procedural imaging. We demonstrate results applying this framework to non-rigidly register post-surgical computed tomography (CT) brain images to pre-surgical magnetic resonance images (MRIs) of epilepsy patients who had intra-cranial electroencephalography electrodes surgically implanted. Deformations caused by this surgical procedure, imaging artifacts caused by the electrodes, and the use of multi-modal imaging data make non-rigid registration challenging. Our results show that the use of our proposed framework to constrain the non-rigid registration process results in significantly improved and more robust registration performance compared to using standard rigid and non-rigid registration methods.
authors.affiliation: Department of Radiology & Biomedical Imaging, Yale University, New Haven, CT, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Onofrey
authors.affiliation: Department of Radiology & Biomedical Imaging, Yale University, New Haven, CT, USA; Department of Electrical Engineering, Yale University, New Haven, CT, USA; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Staib
authors.affiliation: Department of Radiology & Biomedical Imaging, Yale University, New Haven, CT, USA; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
authors.forename: Xenophon
authors.initials: X
authors.lastname: Papademetris
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001696:Biomechanical Phenomena; D001921:Brain / Q000473:pathology*; D003627:Data Interpretation, Statistical; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Computed tomography (CT); Epilepsy; Magnetic resonance imaging (MRI); Non-rigid registration; Statistical deformation model; Surgical navigation