title: Serum anti-lysozyme is associated with disease activity of Behçet's disease.
abstract: OBJECTIVE
  We investigated the association between autoantibodies against non-myeloperoxidase (MPO) neutrophil granule antigens and activity of Behçet's disease (BD).
  
  
  METHODS
  We consecutively enrolled 51 BD patients. We assessed clinical data and BD activity using patients' index scores from the Behçet's Disease Current Activity Form and we performed tests for antibodies against proteinase 3 (PR3), MPO, bactericidal permeability increasing protein (BPI), cathepsin G, elastase, lactoferrin and lysozyme.
  
  
  RESULTS
  The median patient index score was 2.0, and 56.9% of patients had active BD. In multivariate analysis of variables with significant correlations, only anti-lysozyme showed a significant correlation with BD activity (P = 0.002). In multivariate logistic regression analyses of variables, when patients were classified into groups according to the optimal cutoff levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and anti-lysozyme (ESR > 42.5 mm/h, CRP > 1.35 mg/L and anti-lysozyme > 2.95 IU/mL), the variable with independent predictive value was anti-lysozyme (odds ratio 8.384, P = 0.015).
  
  
  CONCLUSIONS
  Anti-lysozyme was significantly correlated with disease activity score and it was the only independent value to predict active disease in patients with BD. Furthermore, patients having anti-lysozyme levels ≥ 2.95 IU/mL had a significantly higher risk of having active BD than those who did not.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, NHIS Ilsan Hospital, Goyang-si, South Korea.
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Park
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Dankook University Hospital, Cheonan, South Korea.
authors.forename: Mi-Il
authors.initials: MI
authors.lastname: Kang
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
authors.forename: You-Jung
authors.initials: YJ
authors.lastname: Ha
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Jason Jungsik
authors.initials: JJ
authors.lastname: Song
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Yong-Beom
authors.initials: YB
authors.lastname: Park
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Soo-Kon
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001528:Behcet Syndrome / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009113:Muramidase / Q000276:immunology*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D009113:Muramidase
keywords: 
  BDCAF
  ; Behçet's disease; anti-lysozyme; disease activity