title: Determination of 3,4-methylenedioxypyrovalerone (MDPV) in oral and nasal fluids by ion mobility spectrometry.
abstract: A fast and sensitive methodology has been developed for the evaluation of the 3,4-methylenedioxypyrovalerone (MDPV) consumed. Based on ion mobility spectrometry (IMS), MDPV was directly determined in nasal fluids with a limit of detection (LOD) in the order of 22 ng mL(-1), which corresponds to an absolute amount of 33 ng of MDPV per swab. MDPV was also determined after liquid-liquid microextraction (LLME) in oral fluids to avoid matrix effects, obtaining a LOD value of 4.4 ng mL(-1) in oral fluid samples. The IMS spectrum for MDPV exhibited a peak with K0 = 1.210 ± 0.005 cm(2)V(-1) s(-1) at a drift time of 14.62 ms, the total analysis time being 4.5 min per oral fluid and 1.5 min per nasal fluid sample. Samples must be analyzed within 24 h following collection and dissolution in 2-propanol, based on the complementary stability studies.
authors.affiliation: Department of Analytical Chemistry, Research Building, University of Valencia, Dr Moliner 50, 46100, Burjassot, Valencia, Spain.
authors.forename: Maria de las Nieves
authors.initials: Mde L
authors.lastname: Peiró
authors.affiliation: Department of Analytical Chemistry, Research Building, University of Valencia, Dr Moliner 50, 46100, Burjassot, Valencia, Spain. sergio.armenta@uv.es.
authors.forename: Sergio
authors.initials: S
authors.lastname: Armenta
authors.affiliation: Department of Analytical Chemistry, Research Building, University of Valencia, Dr Moliner 50, 46100, Burjassot, Valencia, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Garrigues
authors.affiliation: Department of Analytical Chemistry, Research Building, University of Valencia, Dr Moliner 50, 46100, Burjassot, Valencia, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: de la Guardia
mesh_terms: D052117:Benzodioxoles / Q000032:analysis*; D001826:Body Fluids / Q000737:chemistry*; D005260:Female; D006801:Humans; D057230:Limit of Detection; D008297:Male; D009055:Mouth / Q000737:chemistry*; D009296:Nasal Cavity / Q000737:chemistry*; D011759:Pyrrolidines / Q000032:analysis*; D013057:Spectrum Analysis / Q000379:methods*; D000094982:Synthetic Cathinone
chemical_list: D052117:Benzodioxoles; D011759:Pyrrolidines; D000094982:Synthetic Cathinone
keywords: 3,4-Methylenedioxypyrovalerone; Ion mobility spectrometry; MDPV; Nasal fluid; Oral fluid