title: Lifor Solution: An Alternative Preservation Solution in Small Bowel Transplantation.
abstract: Background and Objectives. The intestinal mucosa is extremely sensitive to ischemia. Better intestinal preservation is the first step to improve the results of intestinal transplantation. The aim of the study is to investigate the effect of cold Lifor solution on preservation of swine small bowel. Methods. Swine ileum segments (200 cm) were allotransplanted heterotopically after 9-hour cold storage with UW solution (group 1, n = 6), with Lifor solution (group 2, n = 6), or without storage (group 3, n = 6), respectively. After cold storage, mucosal adenosine triphosphate (ATP) concentrations and histopathologic analysis after preservation were performed. At day 7 after the transplantation, intestinal absorptive function was also observed. Results. After 9 h cold preservation, pathological changes, the content of ATP in the intestinal mucosa, and the intestinal absorptive function after transplantation in group 2 were similar to those of group 1. Conclusion. The effect of cold storage of swine small bowel with Lifor solution is similar to that of UW solution. It may provide additional rationale for further exploration of Lifor as an alternative preservation solution in small bowel transplantation.
authors.affiliation: Department of Laparoscopic Surgery Center, Linyi People's Hospital, Shandong University, Linyi 276000, China.
authors.forename: Mingxiao
authors.initials: M
authors.lastname: Guo
authors.affiliation: Department of Laparoscopic Surgery Center, Linyi People's Hospital, Shandong University, Linyi 276000, China.
authors.forename: Chunlei
authors.initials: C
authors.lastname: Lu
authors.affiliation: Department of Laparoscopic Surgery Center, Linyi People's Hospital, Shandong University, Linyi 276000, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Laparoscopic Surgery Center, Linyi People's Hospital, Shandong University, Linyi 276000, China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Laparoscopic Surgery Center, Linyi People's Hospital, Shandong University, Linyi 276000, China.
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Yousheng
authors.initials: Y
authors.lastname: Li