title: Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice.
abstract: Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans. In this report, we provide converging evidence indicating that a splice variant isoform of the Acbd7 mRNA is expressed and translated by some POMC and GABAergic-neurons in the hypothalamic arcuate nucleus (ARC). We have demonstrated that the ARC ACBD7 isoform was produced and processed into a bioactive peptide referred to as nonadecaneuropeptide (NDN) in response to catabolic signals. We have characterized NDN as a potent anorexigenic signal acting through an uncharacterized endozepine G protein-coupled receptor and subsequently via the melanocortin system. Our results suggest that ACBD7-producing neurons participate in the hypothalamic leptin signalling pathway. Taken together, these data suggest that ACBD7-producing neurons are involved in the hypothalamic control exerted on food intake and energy expenditure by the leptin-melanocortin pathway.
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada.
authors.forename: Damien
authors.identifier: http://orcid.org/0000-0002-3326-9896
authors.initials: D
authors.lastname: Lanfray
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada.
authors.forename: Alexandre
authors.identifier: http://orcid.org/0000-0001-6939-6136
authors.initials: A
authors.lastname: Caron
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Roy
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Laplante
authors.affiliation: Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institut National de la Santé et de la Recherche Médicale, Mont-Saint-Aignan, France.|Institute for Research and Innovation in Biomedicine, Normandy University, Mont-Saint-Aignan, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Morin
authors.affiliation: Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institut National de la Santé et de la Recherche Médicale, Mont-Saint-Aignan, France.|Institute for Research and Innovation in Biomedicine, Normandy University, Mont-Saint-Aignan, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Leprince
authors.affiliation: Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institut National de la Santé et de la Recherche Médicale, Mont-Saint-Aignan, France.|Institute for Research and Innovation in Biomedicine, Normandy University, Mont-Saint-Aignan, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Tonon
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada.
authors.forename: Denis
authors.initials: D
authors.lastname: Richard
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000378:metabolism; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D004435:Eating; D004734:Energy Metabolism; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism
chemical_list: C000612603:ACBD7 protein, mouse; D001067:Appetite Depressants; D002352:Carrier Proteins; D009479:Neuropeptides
keywords: arcuate nucleus; cell biology; hypothalamus; leptin signaling; melanocortin system; mouse; neuroscience