title: Let It Go and Open Up, an Ensemble of Ion Channel Active States.
abstract: Ligand binding usually moves the target protein from an ensemble of inactive states to a well-defined active conformation. Matthies et al. flip this scheme around, finding that, for the magnesium channel CorA, loss of ligand binding induces an ensemble of conformations that turn the channel on.
authors.affiliation: Cardiovascular Research Institute, Departments of Biochemistry and Biophysics and Cellular and Molecular Pharmacology, and California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, California 94158 USA; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 USA. Electronic address: daniel.minor@ucsf.edu.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Minor
mesh_terms: D001426:Bacterial Proteins / Q000648:ultrastructure*; D027682:Cation Transport Proteins / Q000648:ultrastructure*; D008274:Magnesium / Q000378:metabolism*; D020124:Thermotoga maritima / Q000737:chemistry*
chemical_list: D001426:Bacterial Proteins; D027682:Cation Transport Proteins; D008274:Magnesium