title: Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer.
abstract: Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore 138673, Singapore; Yale-NUS Liberal Arts College, Singapore 138527, Singapore. Electronic address: melissa.fullwood@nus.edu.sg.
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Fullwood
mesh_terms: D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000473:pathology*; D016376:Oligonucleotides, Antisense / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D002843:Chromatin; D035683:MicroRNAs; D016376:Oligonucleotides, Antisense; D062085:RNA, Long Noncoding
keywords: Antisense oligonucleotides; Cancer; Chromatin; Transcription regulation; lncRNAs