title: Molecular surveillance of antimalarial drug resistance related genes in Plasmodium falciparum isolates from Eritrea.
abstract: The introduction of artemisinin-based combination therapy has led to extraordinary results in malaria control, however the recent emergence of partial resistance to artemisinin therapy in Southeast Asia jeopardizes these successes. This study aimed at investigating resistance to the antimalarial drugs by evaluating the polymorphisms in the PfK13, Pfcrt and Pfmdr1 genes in Plasmodium falciparum isolates obtained from patients in Eritrea.
authors.affiliation: Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. Electronic address: michela.menegon@iss.it.
authors.forename: Michela
authors.initials: M
authors.lastname: Menegon
authors.affiliation: Faculty of Medical Laboratory Sciences, University of Gezira, P.O. Box 20, Wad Medani, Sudan. Electronic address: peace.abdu@gmail.com.
authors.forename: Abduselam M
authors.initials: AM
authors.lastname: Nurahmed
authors.affiliation: Faculty of Medical Laboratory Sciences, University of Gezira, P.O. Box 20, Wad Medani, Sudan. Electronic address: badawiat@yahoo.com.
authors.forename: Albadawi A
authors.initials: AA
authors.lastname: Talha
authors.affiliation: Blue Nile Research National Institute for Communicable Diseases, University of Gezira, P.O. Box 20, Wad Medani, Sudan. Electronic address: bakrinour@gmail.com.
authors.forename: Bakri Y M
authors.initials: BY
authors.lastname: Nour
authors.affiliation: Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. Electronic address: carlo.severini@iss.it.
authors.forename: Carlo
authors.initials: C
authors.lastname: Severini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance / Q000235:genetics*; D019017:Eritrea / Q000453:epidemiology; D005260:Female; D017125:Genes, Protozoan; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000235:genetics*; D011110:Polymorphism, Genetic; D015995:Prevalence; D055815:Young Adult
chemical_list: D000962:Antimalarials; D037621:Artemisinins; C031327:artemisinin
keywords: Drug resistance; Eritrea; Kelch 13 propeller; Pfcrt; Pfmdr1; Plasmodium falciparum