title: Nanoemulsion: A Novel Eon in Cancer Chemotherapy.
abstract: Cancer refers to an assemblage of lethal diseases characterized by abnormal growth of cells. The most celebrated adverse effects accredited to the cytotoxic class of anticancer agents are constructed owing to their inability to differentiate between the abnormally multiplying cancerous cell mass and the rapidly dividing healthy cells of the human body. Consequently, unknown targets chemotherapy for cancer play host to a multitude of adverse effects ranging from nausea, alopecia to torturous ages associated with the current treatment etiquette. Nano-pharmaceuticals constitute the advanced scale drug targeting technologies. Nanoemulsion is an important tool in the nano-technological arena designed for clinical and therapeutic application. Currently among different nano-carriers, nanoemulsions are extensively envisaged as efficient drug delivery systems for the targeted delivery of lipophilic cytotoxic antineoplastic agents. Beauties of nanoemulsion include optical clarity, biocompatibility, non-immunogenic, biodegradable, drug encapsulation, sustained and controlled release, nanometric size, large surface area, ease of preparation and thermodynamic stability. After excessive delving, the research fraternity has acknowledged nanoemulsions as proficient nanocarriers capable of effectively addressing the low bioavailability and noncompliance issues associated with the conventional anticancerous chemotherapeutic dosage forms. This review attempts to shed new light on the current status of nanoemulsion in the cancer therapeutics, and commercial field on the basis of morphology, formulation, characteristics and characterization parameters.
authors.affiliation: Department of Pharmaceutical Sciences, Dr. H.S. Gour Central University, Sagar, MP. India.
authors.forename: Prashant
authors.initials: P
authors.lastname: Sahu
authors.affiliation: Department of Pharmaceutical Sciences, Dr. H.S. Gour Central University, Sagar, MP. India.
authors.forename: Debashree
authors.initials: D
authors.lastname: Das
authors.affiliation: Department of Pharmaceutical Sciences, Dr. H.S. Gour Central University, Sagar, MP. India.
authors.forename: Vikash K
authors.initials: VK
authors.lastname: Mishra
authors.affiliation: Sagar Institute of Pharmaceutical Sciences, Sagar, MP. India.
authors.forename: Varsha
authors.initials: V
authors.lastname: Kashaw
authors.affiliation: Department of Pharmaceutical Sciences, Dr. H.S. Gour Central University, Sagar, MP. India.
authors.forename: Sushil Kumar
authors.initials: SK
authors.lastname: Kashaw
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D004655:Emulsions / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D004655:Emulsions
keywords: Characterization; commercial brands cancer chemotherapy; drug delivery; nanoemulsion; patents; preparation