title: Sub-diffuse optical biomarkers characterize localized microstructure and function of cortex and malignant tumor.
abstract: This study uses a sub-diffusive light transport model to analyze fiber-optic measurements of reflectance spectra to recover endogenous tissue biomarkers and to correct raw fluorescence emissions for distortions from background optical properties. Measurements in tissue-simulating phantoms validated accurate recovery of the reduced scattering coefficient [(0.3-3.4  mm-1), error 10%], blood volume fraction [(1-3 vol%), error 7%], and a dimensionless metric of anisotropic scattering, γ, that is sensitive to submillimeter tissue ultrastructure [(1.29-2.06), error 11%]. In vivo sub-diffusive optical data acquired during clinical neurosurgeries characterize differences in microstructure (γ), perfusion (blood volume), and metabolism (PpIX fluorescence) between normal cortex and malignant tumor.
authors.forename: Jaime J
authors.initials: JJ
authors.lastname: Bravo
authors.forename: Keith D
authors.initials: KD
authors.lastname: Paulsen
authors.forename: David W
authors.initials: DW
authors.lastname: Roberts
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Kanick
mesh_terms: D001921:Brain / Q000166:cytology / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D004058:Diffusion; D006801:Humans; D008027:Light; D009010:Monte Carlo Method; D055495:Neurogenesis; D055620:Optical Phenomena; D019047:Phantoms, Imaging