title: Efficacy of covered and bare stent in TIPS for cirrhotic portal hypertension: A single-center randomized trial.
abstract: We conducted a single-center randomized trial to compare the efficacy of 8 mm Fluency covered stent and bare stent in transjugular intrahepatic portosystemic shunt (TIPS) for cirrhotic portal hypertension. From January 2006 to December 2010, the covered (experimental group) or bare stent (control group) was used in 131 and 127 patients, respectively. The recurrence rates of gastrointestinal bleeding (18.3% vs. 33.9%, P = 0.004) and refractory hydrothorax/ascites (6.9% vs. 16.5%, P = 0.019) in the experimental group were significantly lower than those in the control group. The cumulative restenosis rates in 1, 2, 3, 4, and 5-years in the experimental group (6.9%, 11.5%, 19.1%, 26.0%, and 35.9%, respectively) were significantly lower (P < 0.001) than those in the control group (27.6%, 37.0%, 49.6%, 59.8%, 74.8%, respectively). Importantly, the 4 and 5-year survival rates in the experimental group (83.2% and 76.3%, respectively) were significantly higher (P = 0.001 and 0.02) than those in the control group (71.7% and 62.2%, respectively). The rate of secondary interventional therapy in the experimental group was significantly lower than that in the control group (20.6% vs. 49.6%; P < 0.001). Therefore, Fluency covered stent has advantages over the bare stent in terms of reducing the restenosis, recurrence, and secondary interventional therapy, whereas improving the long-term survival for post-TIPS patients.
authors.affiliation: Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, P.R., China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Plastic Surgery, The Second Affiliated Hospital of Harbin Medical University, P.R., China.
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Xiao
authors.affiliation: Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, P.R., China.
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Yue
authors.affiliation: Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, P.R., China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, P.R., China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Fan
authors.affiliation: Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, P.R., China.
authors.forename: Mengfei
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, P.R., China.
authors.forename: Fuliang
authors.initials: F
authors.lastname: He
authors.affiliation: Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, P.R., China.
authors.forename: Shan
authors.initials: S
authors.lastname: Dai
authors.affiliation: Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, P.R., China.
authors.forename: Bin
authors.initials: B
authors.lastname: Qiu
authors.affiliation: Chaoyang Hospital, Capital Medical University, P.R., China.
authors.forename: Jiannan
authors.initials: J
authors.lastname: Yao
authors.affiliation: Department of Gastroenterology, Stephenson Cancer Center, Department of Internal Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, USA.
authors.forename: Qiushi
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, P.R., China.|Department of Gastroenterology, Stephenson Cancer Center, Department of Internal Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, USA.
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Dong
authors.affiliation: Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, P.R., China.
authors.forename: Fuquan
authors.initials: F
authors.lastname: Liu
mesh_terms: D000328:Adult; D054855:Drug-Eluting Stents; D005260:Female; D041981:Gastrointestinal Tract / Q000473:pathology; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000009:adverse effects / Q000379:methods*