title: Aza-Conjugate Addition Methodology for the Synthesis of N-Hydroxy-isoindolin-1-ones.
abstract: Aryl-aldehydes containing ortho-substituted propiolate fragments react with hydroxylamine to afford carbinolamine intermediates that undergo intramolecular aza-conjugate addition reactions to afford N-hydroxy-2.3-dihydro-isoindolin-1-ones that can be reduced to their corresponding isoindolin-1-ones and isoindoles.
authors.affiliation: Departament de Química Inorgànica i Orgànica, Universitat Jaume I , Castelló, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Royo
authors.affiliation: Department of Chemistry, University of Bath , Bath, BA2 7AY, U.K.
authors.forename: Robert S L
authors.initials: RS
authors.lastname: Chapman
authors.affiliation: Department of Chemistry, University of Bath , Bath, BA2 7AY, U.K.
authors.forename: Alisia M
authors.initials: AM
authors.lastname: Sim
authors.affiliation: Department of Chemistry, University of Bath , Bath, BA2 7AY, U.K.
authors.forename: Lucy R
authors.initials: LR
authors.lastname: Peacock
authors.affiliation: Department of Chemistry, University of Bath , Bath, BA2 7AY, U.K.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Bull