title: Seroepidemiology of HTLV-1 and HTLV-2 Infection in Neyshabur City, North-Eastern Iran, during 2010-2014.
abstract: BACKGROUND
  Retroviruses of human T-lymphotropic viruses (HTLV-1 and HTLV-2) have been demonstrated to be endemic in the north-eastern region of Iran. This study was aimed to determine the HTLV-1 and HTLV-2 prevalence among healthy individuals in Neyshabur City during 2010-2014.
  
  
  METHODS
  A total of 8054 blood samples were collected from healthy participants in Neyshabur, North-Eastern Iran. The blood samples were screened for the presence of specific antibodies against HTLV-1 and HTLV-2 by using ELISA according to the manufacturer's instructions.
  
  
  RESULTS
  The overall seropositivity rate for HTLV-1 and HTLV-2 was found to be 6.55% (528 out of 8054) among participants.
  
  
  CONCLUSIONS
  Both HTLV-1 and HTLV-2 were demonstrated to be at a high rate in healthy individuals. However, a smaller number of asymptomatic carriers were found in this study, as compared to those identified in previous investigations in the city.
authors.affiliation: Medical Diagnostic Laboratory of Neyshabour, Center of Medical, Pathological and Genetic Diagnostic Services, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Salehi
authors.affiliation: Department of Microbiology, Islamic Azad University, Tehran Medical Science Branch, Tehran, Iran.
authors.forename: Seyyed Khalil
authors.initials: SK
authors.lastname: Shokouhi Mostafavi
authors.affiliation: Department of Microbiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.
authors.forename: Abdolmajid
authors.initials: A
authors.lastname: Ghasemian
authors.affiliation: Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Gholami
authors.affiliation: Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Abdolrahim
authors.initials: A
authors.lastname: Kazemi-Vardanjani
authors.affiliation: Department of Microbiology, Islamic Azad University, Tehran Medical Science Branch, Tehran, Iran.
authors.forename: Mohammad Karim
authors.initials: MK
authors.lastname: Rahimi
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood*; D015490:HTLV-I Infections / Q000453:epidemiology* / Q000821:virology; D015482:HTLV-II Antibodies / Q000097:blood*; D015491:HTLV-II Infections / Q000453:epidemiology* / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D015367:Human T-lymphotropic virus 2 / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007492:Iran / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D015481:HTLV-I Antibodies; D015482:HTLV-II Antibodies
keywords: Enzyme-linked immunosorbent assay; Human T-lymphotropic viruse; Iran; Seroepidemiology