title: Electroacupuncture Produces the Sustained Motor Improvement in 6-Hydroxydopamine-Lesioned Mice.
abstract: Clinical and research evidence has shown that electroacupuncture (EA) promotes recovery of motor function in patients with Parkinson's disease (PD). However, the "efficacy span" of EA treatment, especially the long-term effect of EA that is thought to last after the cessation of EA treatment, has not been investigated. The present study thus investigated and compared the effect of EA during and after chronic EA application on motor activity and dopamine lesions in a 6-hydroxydopamine (6-OHDA)-lesioned mouse model of PD. Chronic EA treatment (30 min a day, 6 days a week for 2 or 4 weeks) significantly attenuated motor deficiency and reduced dopamine neuron degeneration. Remarkably, EA showed a long-lasting effect after the cessation of EA stimulation. At 2 and 4 weeks after the termination of EA, EA continued to improve motor function in 6-OHDA-lesioned mice. Consistent with sustained behavioral effects, EA induced an enduring increase in the dopamine turnover ratio in the striatum 2 weeks after the cessation of EA treatment. Here we demonstrated that the therapeutic effect of EA outlasted the duration of EA application. During a relatively long period of time after the completion of EA treatment, EA is able to continue to improve motor function and enhance dopamine availability in 6-OHDA-lesioned PD mice.
authors.affiliation: Departments of Neurobiology and Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Capital Medical University, Beijing Institute for Brain Disorders, Beijing, 100069, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Departments of Neurobiology and Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Capital Medical University, Beijing Institute for Brain Disorders, Beijing, 100069, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.affiliation: Departments of Neurobiology and Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Capital Medical University, Beijing Institute for Brain Disorders, Beijing, 100069, China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Deng
authors.affiliation: Departments of Neurobiology and Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Capital Medical University, Beijing Institute for Brain Disorders, Beijing, 100069, China.
authors.forename: Min
authors.initials: M
authors.lastname: Sun
authors.affiliation: Departments of Neurobiology and Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Capital Medical University, Beijing Institute for Brain Disorders, Beijing, 100069, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jia
authors.affiliation: Departments of Neurobiology and Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Capital Medical University, Beijing Institute for Brain Disorders, Beijing, 100069, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D059290:Dopaminergic Neurons / Q000378:metabolism / Q000473:pathology; D015671:Electroacupuncture / Q000379:methods; D008297:Male; D051379:Mice; D016627:Oxidopamine / Q000008:administration & dosage / Q000009:adverse effects; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D005082:Physical Exertion
chemical_list: D016627:Oxidopamine; D004298:Dopamine