title: Effects of low-dose niacin on dyslipidemia and serum phosphorus in patients with chronic kidney disease.
abstract: BACKGROUND
  Niacin supplementation improves dyslipidemia and lowers serum phosphorus levels in patients with chronic kidney disease (CKD). We evaluated whether low-dose niacin supplementation can improve dyslipidemia, lower serum phosphorus levels, and be administered with a low frequency of adverse effects in patients with CKD.
  
  
  METHODS
  We retrospectively analyzed the clinical records of patients with CKD who had taken niacin from January 2009 to June 2011. We excluded patients with CKD stage 1 and 5. We then enrolled 31 patients with CKD who had taken niacin at a fixed dose of 500 mg/day for 6 months. We also randomly selected 30 patients with CKD who had been taking statin for 9 months as a control group.
  
  
  RESULTS
  Among the 34 patients with CKD who were prescribed niacin, five (14%) complained of adverse effects, and three (8%) discontinued niacin. The proportion of patients in the niacin group who had been taking a statin or omega-3 fatty acids was 67.7% and 48.8%, respectively. In the niacin group, high-density lipoprotein cholesterol level was significantly increased and triglyceride level was significantly decreased at 12 and 24 weeks compared with baseline levels (P<0.05). In the niacin group, phosphorous level (P<0.05) was significantly decreased, and glomerular filtration rate (GFR) was significantly increased (P<0.05) at 24 weeks compared with baseline values.
  
  
  CONCLUSIONS
  Low-dose niacin had a low frequency of adverse effects and also improved dyslipidemia, lowered serum phosphorus level, and increased GFR in patients with CKD. Further studies are needed to evaluate the long-term effects of low-dose niacin for renal progression of CKD.
authors.affiliation: Department of Internal Medicine, Dong-A University Medical School, Busan, Korea.
authors.forename: Hyo
authors.initials: H
authors.lastname: Jin Kang
authors.affiliation: Department of Internal Medicine, Dong-A University Medical School, Busan, Korea.
authors.forename: Do Kyong
authors.initials: DK
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Dong-A University Medical School, Busan, Korea.
authors.forename: Su
authors.initials: S
authors.lastname: Mi Lee
authors.affiliation: Department of Internal Medicine, Dong-A University Medical School, Busan, Korea.
authors.forename: Kyung
authors.initials: K
authors.lastname: Han Kim
authors.affiliation: Department of Internal Medicine, Dong-A University Medical School, Busan, Korea.
authors.forename: Seung
authors.initials: S
authors.lastname: Hee Han
authors.affiliation: Department of Internal Medicine, Dong-A University Medical School, Busan, Korea.
authors.forename: Ki
authors.initials: K
authors.lastname: Hyun Kim
authors.affiliation: Department of Internal Medicine, Dong-A University Medical School, Busan, Korea.
authors.forename: Seong
authors.initials: S
authors.lastname: Eun Kim
authors.affiliation: Department of Internal Medicine, Dong-A University Medical School, Busan, Korea.
authors.forename: Young
authors.initials: Y
authors.lastname: Ki Son
authors.affiliation: Department of Internal Medicine, Dong-A University Medical School, Busan, Korea.
authors.forename: Won Suk
authors.initials: WS
authors.lastname: An
keywords: Adverse effects; Dyslipidemia; Glomerular filtration rate; Niacin; Phosphorus