title: Human pegivirus detected in a patient with severe encephalitis using a metagenomic pan-virus array.
abstract: We have used a metagenomic microarray to detect genomic RNA from human pegivirus in serum and cerebrospinal fluid from a patient suffering from severe encephalitis. No other pathogen was detected. HPgV in cerebrospinal fluid during encephalitis has never been reported before and its prevalence in cerebrospinal fluid needs further investigation.
authors.affiliation: Virus Research and Development, Department of Microbiological Diagnostics and Virology, Statens Serum Institut, Copenhagen, Denmark. Electronic address: HEFR@ssi.dk.
authors.forename: Helena
authors.initials: H
authors.lastname: Fridholm
authors.affiliation: Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Line
authors.initials: L
authors.lastname: Østergaard Sørensen
authors.affiliation: Virus Research and Development, Department of Microbiological Diagnostics and Virology, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Maiken W
authors.initials: MW
authors.lastname: Rosenstierne
authors.affiliation: Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Nielsen
authors.affiliation: Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Finn
authors.initials: F
authors.lastname: Sellebjerg
authors.affiliation: Infectious Disease Research Unit, Clinical Institute, University of Southern Denmark, Denmark.
authors.forename: Åse
authors.initials: Å
authors.lastname: Bengård Andersen
authors.affiliation: Virus Research and Development, Department of Microbiological Diagnostics and Virology, Statens Serum Institut, Copenhagen, Denmark; Infectious Disease Research Unit, Clinical Institute, University of Southern Denmark, Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Fomsgaard
mesh_terms: D000328:Adult; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000821:virology*; D005260:Female; D018067:Flaviviridae / Q000145:classification / Q000235:genetics*; D006801:Humans; D056186:Metagenomics / Q000379:methods; D060888:Real-Time Polymerase Chain Reaction; D012698:Serologic Tests
keywords: Encephalitis; HPgV; Metagenomics; Microarray