title: Left ventricular wall thickness in patients with hypertrophic cardiomyopathy: a comparison between cardiac magnetic resonance imaging and echocardiography.
abstract: We assessed whether cardiac MRI (CMR) and echocardiography (echo) have significant differences measuring left ventricular (LV) wall thickness (WT) in hypertrophic cardiomyopathy (HCM) as performed in the clinical routine. Retrospectively identified, clinically diagnosed HCM patients with interventricular-septal (IVS) pattern hypertrophy who underwent CMR and echo within the same day were included. Left Ventricular WT was measured by CMR in two planes and compared to both echo and contrast echo (cecho). 72 subjects, mean age 50.7 ± 16.2 years, 68 % males. Interventricular septal WT by echo and CMR planes showed good to excellent correlation. However, measurements of the postero-lateral wall showed poor correlation. Bland-Altman plots showed greater maximal IVS WT by echo compared to CMR measurement [SAX = 1.7 mm (-5.8, 9.3); LVOT = 1.1 mm (-5.6, 7.8)]. Differences were smaller between cecho and CMR [SAX = 0.8 mm (-9.2, 10.8); LVOT = -0.2 mm (-10.0, 9.6)]. Severity of WT by quartiles showed greater differences between echo and SAX CMR WT compared to cecho. Echocardiography typically measures greater WT than CMR, with the largest differences in moderate to severe hypertrophy. Contrast echocardiography more closely approximates CMR measurements of WT. These findings have potential clinical implications for risk stratification of subjects with HCM.
authors.affiliation: The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 601 North Caroline Street; JHOC 3142, Box 0818, Baltimore, MD, 21287, USA.
authors.forename: Celia P
authors.initials: CP
authors.lastname: Corona-Villalobos
authors.affiliation: Division of Cardiology, Johns Hopkins University School of Medicine, Harvey 611, Baltimore, MD, 21287, USA.
authors.forename: Lars L
authors.initials: LL
authors.lastname: Sorensen
authors.affiliation: Division of Cardiology, Johns Hopkins University School of Medicine, Harvey 611, Baltimore, MD, 21287, USA.
authors.forename: Iraklis
authors.initials: I
authors.lastname: Pozios
authors.affiliation: The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 601 North Caroline Street; JHOC 3142, Box 0818, Baltimore, MD, 21287, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Chu
authors.affiliation: The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 601 North Caroline Street; JHOC 3142, Box 0818, Baltimore, MD, 21287, USA.
authors.forename: John
authors.initials: J
authors.lastname: Eng
authors.affiliation: Division of Cardiology, Johns Hopkins University School of Medicine, Harvey 611, Baltimore, MD, 21287, USA.
authors.forename: Maria Roselle
authors.initials: MR
authors.lastname: Abraham
authors.affiliation: Division of Cardiology, Johns Hopkins University School of Medicine, Harvey 611, Baltimore, MD, 21287, USA.
authors.forename: Theodore P
authors.initials: TP
authors.lastname: Abraham
authors.affiliation: The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 601 North Caroline Street; JHOC 3142, Box 0818, Baltimore, MD, 21287, USA.
authors.forename: Ihab R
authors.initials: IR
authors.lastname: Kamel
authors.affiliation: The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 601 North Caroline Street; JHOC 3142, Box 0818, Baltimore, MD, 21287, USA. stefan.zimmerman@jhmi.edu.
authors.forename: Stefan L
authors.initials: SL
authors.lastname: Zimmerman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling; D055815:Young Adult
keywords: Cardiac magnetic resonance imaging; Echocardiography; Hypertrophic cardiomyopathy; Inter-study variability; Wall thickness