title: Efficiency of Cell Therapy in Liver Cirrhosis.
abstract: We studied safety and clinical efficacy of transplantation of autologous bone marrow cell in complex therapy of 158 patients with chronic hepatitis and cirrhosis of the liver. The efficiency of cell therapy was assessed in 12 months after single injection of the cells. The positive response (alleviation of liver cirrhosis or stabilization of the pathological process) was observed in 70% cases. The efficacy of therapy correlated with the severity and etiology of the disease and was maximum in patients with Child-Pugh class A (in 82.5% cases) and class B liver cirrhosis (in 79% cases); in patients with class C liver cirrhosis, the positive response was achieved in 42.5% cases. In 39 patients, ultrasonic examination performed in 3 years after transplantation revealed no focal lesions or ectopic ossification foci.
authors.affiliation: Research Institute of Clinical Immunology, Novosibirsk, Russia. ct_lab@mail.ru.
authors.forename: E Ya
authors.initials: EY
authors.lastname: Shevela
authors.affiliation: Research Institute of Clinical Immunology, Novosibirsk, Russia.
authors.forename: N M
authors.initials: NM
authors.lastname: Starostina
authors.affiliation: Research Institute of Clinical Immunology, Novosibirsk, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Pal'tsev
authors.affiliation: Research Institute of Clinical Immunology, Novosibirsk, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Shipunov
authors.affiliation: Research Institute of Clinical Immunology, Novosibirsk, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Zheltova
authors.affiliation: Research Institute of Clinical Immunology, Novosibirsk, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Meledina
authors.affiliation: Research Institute of Clinical Immunology, Novosibirsk, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Khvan
authors.affiliation: Research Institute of Clinical Immunology, Novosibirsk, Russia.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Leplina
authors.affiliation: Research Institute of Clinical Immunology, Novosibirsk, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Ostanin
authors.affiliation: Research Institute of Clinical Immunology, Novosibirsk, Russia.
authors.forename: E R
authors.initials: ER
authors.lastname: Chernykh
authors.affiliation: Research Institute of Clinical Immunology, Novosibirsk, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Kozlov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells / Q000166:cytology; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D005260:Female; D006521:Hepatitis, Chronic / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D055815:Young Adult
keywords: bone marrow; cirrhosis of the liver; stem cells; transplantation