title: Thirty years old lady with nephrotic syndrome: a case of biopsy proven lupus nephritis in Tanzania.
abstract: We describe a case of a 30 years old female patient who presented with nephrotic syndrome and impaired renal function diagnosed to have systemic lupus erythematosus (SLE). This is the first biopsy proven lupus nephritis in Tanzania. SLE is common among females and is reported be more common among Africans as compared to other races. This patient presented with nephrotic syndrome, pleural effusion and pericardial effusion which depicts the multisystem effects of SLE. This patient was treated with cyclophosphamide in combination with steroid as induction therapy and attained remission after a month of treatment. Systemic lupus erythematosus should be considered in patients with nephrotic syndrome and these patients should have renal biopsy to determine renal involvement.
authors.forename: Francis
authors.initials: F
authors.lastname: Fredrick
authors.forename: Paschal J
authors.initials: PJ
authors.lastname: Ruggajo
authors.forename: Gyaviira
authors.initials: G
authors.lastname: Makanga
authors.forename: Charles K
authors.initials: CK
authors.lastname: Shija
authors.forename: Mikael
authors.initials: M
authors.lastname: Amdemariam
authors.forename: Belson
authors.initials: B
authors.lastname: Rugwizagonga
authors.forename: James N
authors.initials: JN
authors.lastname: Kitinya
mesh_terms: D000328:Adult; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007677:Kidney Function Tests; D008181:Lupus Nephritis / Q000150:complications* / Q000188:drug therapy*; D009404:Nephrotic Syndrome / Q000209:etiology; D010490:Pericardial Effusion / Q000209:etiology; D010996:Pleural Effusion / Q000209:etiology; D013256:Steroids / Q000627:therapeutic use; D013636:Tanzania
chemical_list: D007166:Immunosuppressive Agents; D013256:Steroids; D003520:Cyclophosphamide