title: Phenotypic Characterization of Juvenile Idiopathic Arthritis in African American Children.
abstract: OBJECTIVE
  Juvenile idiopathic arthritis (JIA) affects children of all races. Prior studies suggest that phenotypic features of JIA in African American (AA) children differ from those of non-Hispanic white (NHW) children. We evaluated the phenotypic differences at presentation between AA and NHW children enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry, and replicated the findings in a JIA cohort from a large center in the southeastern United States.
  
  
  METHODS
  Children with JIA enrolled in the multicenter CARRA Registry and from Emory University formed the study and replication cohorts. Phenotypic data on non-Hispanic AA children were compared with NHW children with JIA using the chi-square test, Fisher's exact test, and the Wilcoxon signed-rank test.
  
  
  RESULTS
  In all, 4177 NHW and 292 AA JIA cases from the CARRA Registry and 212 NHW and 71 AA cases from Emory were analyzed. AA subjects more often had rheumatoid factor (RF)-positive polyarthritis in both the CARRA (13.4% vs 4.7%, p = 5.3 × 10(-7)) and the Emory (26.8% vs 6.1%, p = 1.1 × 10(-5)) cohorts. AA children had positive tests for RF and cyclic citrullinated peptide antibodies (CCP) more frequently, but oligoarticular or early onset antinuclear antibody (ANA)-positive JIA less frequently in both cohorts. AA children were older at onset in both cohorts and this difference persisted after excluding RF-positive polyarthritis in the CARRA Registry (median age 8.5 vs 5.0 yrs, p = 1.4 × 10(-8)).
  
  
  CONCLUSIONS
  Compared with NHW children, AA children with JIA are more likely to have RF/CCP-positive polyarthritis, are older at disease onset, and less likely to have oligoarticular or ANA-positive, early-onset JIA, suggesting that the JIA phenotype is different in AA children.
authors.forename: Lauren
authors.initials: L
authors.lastname: Fitzpatrick
authors.forename: K Alaine
authors.initials: KA
authors.lastname: Broadaway
authors.forename: Lori
authors.initials: L
authors.lastname: Ponder
authors.forename: Sheila T
authors.initials: ST
authors.lastname: Angeles-Han
authors.forename: Kirsten
authors.initials: K
authors.lastname: Jenkins
authors.forename: Kelly
authors.initials: K
authors.lastname: Rouster-Stevens
authors.forename: Christina F
authors.initials: CF
authors.lastname: Pelajo
authors.forename: Karen
authors.initials: K
authors.lastname: Conneely
authors.forename: Michael P
authors.initials: MP
authors.lastname: Epstein
authors.forename: Jorge
authors.initials: J
authors.lastname: Lopez-Benitez
authors.forename: Larry B
authors.initials: LB
authors.lastname: Vogler
authors.forename: Sampath
authors.initials: S
authors.lastname: Prahalad
mesh_terms: D001741:Black or African American; D001171:Arthritis, Juvenile / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010456:Peptides, Cyclic / Q000276:immunology*; D010641:Phenotype; D012042:Registries; D012217:Rheumatoid Factor / Q000097:blood; D063189:Symptom Assessment
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor
keywords: AFRICAN AMERICAN; JUVENILE IDIOPATHIC ARTHRITIS; PHENOTYPE; REGISTRIES