title: Excitotoxic Mechanisms in Non-Motor Dysfunctions and Levodopa- Induced Dyskinesia in Parkinson's Disease: The Role of the Interaction Between the Dopaminergic and the Kynurenine System.
abstract: Parkinson's disease is a common progressive neurodegenerative disorder presenting with characteristic motor symptoms. Non-motor dysfunctions and therapyrelated complications frequently develop, but are often underdiagnosed and undertreated. Levodopa- induced dyskinesia and impulse control disorders are suggested to share pathophysiological processes and m a y be related to alterations of the glutamatergic neurotransmission. Anti- glutamatergic interventions are therefore worth considering: several lines of evidence already indicate their beneficial effect. The kynurenine pathway offers the endogenous glutamate receptor antagonist kynurenic acid, which may act as a promising candidate for future drug development with the aim of assessment of the motor symptoms and therapy-related complications of Parkinson's disease.
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Majláth
authors.forename: József
authors.initials: J
authors.lastname: Toldi
authors.forename: Ferenc
authors.initials: F
authors.lastname: Fülöp
authors.affiliation: Department of Neurology, University of Szeged, Semmelweis u.6, H-6725, Szeged Hungary; and MTA-SZTE Neuroscience Research Group of the Hungarian Academy of Sciences and University of Szeged, Semmelweis u.6, H-6725 Szeged, Hungary. vecsei.laszlo@med.u-szeged.hu.
authors.forename: László
authors.initials: L
authors.lastname: Vécsei
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015259:Dopamine Agents / Q000378:metabolism*; D004409:Dyskinesia, Drug-Induced / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007737:Kynurenine / Q000378:metabolism*; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D015394:Molecular Structure; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000978:Antiparkinson Agents; D015259:Dopamine Agents; D007737:Kynurenine; D007980:Levodopa