title: Kinetic Diversity of Striatal Dopamine: Evidence from a Novel Protocol for Voltammetry.
abstract: In vivo voltammetry reveals substantial diversity of dopamine kinetics in the rat striatum. To substantiate this kinetic diversity, we evaluate the temporal distortion of dopamine measurements arising from the diffusion-limited adsorption of dopamine to voltammetric microelectrodes. We validate two mathematical procedures for correcting adsorptive distortion, both of which substantiate that dopamine's apparent kinetic diversity is not an adsorption artifact.
authors.affiliation: Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
authors.forename: Seth H
authors.initials: SH
authors.lastname: Walters
authors.affiliation: Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Robbins
authors.affiliation: Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
authors.forename: Adrian C
authors.initials: AC
authors.lastname: Michael
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D055664:Electrochemical Techniques / Q000379:methods*; D008297:Male; D010599:Pharmacokinetics; D011355:Prodrugs / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D011355:Prodrugs; D004298:Dopamine
keywords: Dopamine; kinetic diversity; modeling; restricted diffusion; voltammetry