title: Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces.
abstract: Complex sphingolipids are essential structural components of intestinal membranes, providing protection and integrity to the intestinal mucosa and regulating intestinal absorption processes. The role of sphingolipid signaling has been established in numerous cellular events, including intestinal cell survival, growth, differentiation, and apoptosis. A significant body of knowledge demonstrates that intestinal sphingolipids play a crucial role, as such and through their signaling pathways, in immunity and inflammatory disorders. In this review, we report on and discuss the current knowledge on the metabolism, signaling, and functional implications of sphingolipids in inflammatory bowel disease (IBD), focusing on the different aspects of sphingolipid actions on inflammatory responses and on the potential of sphingolipid-targeted molecules as anti-IBD therapeutic agents.
authors.affiliation: Department of Medical Biotechnology and Translational Medicine, LITA-Segrate, University of Milan, 20090 Milan, Italy.
authors.forename: Loubna
authors.initials: L
authors.lastname: Abdel Hadi
authors.affiliation: Department of Medical Biotechnology and Translational Medicine, LITA-Segrate, University of Milan, 20090 Milan, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Di Vito
authors.affiliation: Department of Medical Biotechnology and Translational Medicine, LITA-Segrate, University of Milan, 20090 Milan, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Riboni
mesh_terms: D000818:Animals; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000378:metabolism*; D013107:Sphingolipids / Q000378:metabolism*
chemical_list: D013107:Sphingolipids