title: Chemical fragment arrays for rapid druggability assessment.
abstract: Incorporation of early druggability assessment in the drug discovery process provides a means to prioritize target proteins for high-throughput screening. We present chemical fragment arrays as a method that is capable of determining the druggability of a given target with low protein and compound consumption, enabling rapid decision making during early phases of drug discovery.
authors.affiliation: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany. Christoph.Rademacher@mpikg.mpg.de and Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Aretz
authors.affiliation: Antibiotics Laboratory, RIKEN, Wako, Japan and Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kondoh
authors.affiliation: Antibiotics Laboratory, RIKEN, Wako, Japan and Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Honda
authors.affiliation: Leibniz Institut für Molekulare Pharmakologie (FMP), Berlin, Germany.
authors.forename: U R
authors.initials: UR
authors.lastname: Anumala
authors.affiliation: Leibniz Institut für Molekulare Pharmakologie (FMP), Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Nazaré
authors.affiliation: Antibiotics Laboratory, RIKEN, Wako, Japan and Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan and Bioprobe Research Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.affiliation: Antibiotics Laboratory, RIKEN, Wako, Japan and Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan and Bioprobe Research Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Osada
authors.affiliation: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany. Christoph.Rademacher@mpikg.mpg.de and Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Rademacher