title: Strength in Numbers: Visualizing CTL-Mediated Killing In Vivo.
abstract: Cytotoxic CD8+ T lymphocytes (CTLs) have long been believed to be extremely efficient killers. Forster and colleagues (Halle et al., 2016) used in vivo imaging to tell a different story, in which each CTL killed only 2-16 targets a day, and several CTLs per target were needed to get the job done.
authors.affiliation: Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Nolz
authors.affiliation: Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA. Electronic address: hillan@ohsu.edu.
authors.forename: Ann B
authors.initials: AB
authors.lastname: Hill
mesh_terms: D000818:Animals; D006566:Herpesviridae Infections / Q000276:immunology*; D006801:Humans; D018146:Muromegalovirus / Q000276:immunology*; D054353:Perforin / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014615:Vaccinia / Q000276:immunology*; D014616:Vaccinia virus / Q000276:immunology*
chemical_list: D054353:Perforin