title: Fuzhuan tea consumption imparts hepatoprotective effects and alters intestinal microbiota in high saturated fat diet-fed rats.
abstract: Nonalcoholic fatty liver disease is an obesity-related disorder characterized by lipid infiltration of the liver. Management is limited to lifestyle modifications, highlighting the need for alternative therapeutic options. The objective of this study was to examine if fermented Fuzhuan tea prevents metabolic impairments associated with development of hepatic steatosis.
  
  
  
  Rats consumed control (CON) or high saturated fat (SAT) diets with or without Fuzhuan tea for 8 weeks. Outcomes included enzymatic and gene expression measures of metabolic dysregulation in liver and adipose tissue. Pyrosequencing was used to assess intestinal microbiota adaptations. Fuzhuan tea prevented diet-induced inflammation in the liver. Liver triglycerides of ∼18 mg/g were observed in SAT-fed animals, but remained similar to CON diet levels (∼12 mg/g) when supplemented with Fuzhuan tea. In adipose tissue, tea treatment prevented SAT-induced inflammation and reduced plasma leptin approximately twofold. Fuzhuan tea also altered intestinal function and was associated with a threefold increase in two Lactobacillus spp.
  
  
  
  These data suggest that Fuzhuan tea protects against liver and adipose tissue stress induced by a high SAT diet and positively influences intestinal function. Further investigation of the molecular targets of Fuzhuan tea is warranted.
authors.affiliation: Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
authors.forename: Michelle T
authors.initials: MT
authors.lastname: Foster
authors.affiliation: Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Gentile
authors.affiliation: Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Cox-York
authors.affiliation: Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
authors.forename: Yuren
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Estrada
authors.affiliation: Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Reese
authors.affiliation: Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
authors.forename: Tirrel
authors.initials: T
authors.lastname: Miller
authors.affiliation: Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Pagliassotti
authors.affiliation: Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
authors.forename: Tiffany L
authors.initials: TL
authors.lastname: Weir
mesh_terms: D054392:Adipokines / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004269:DNA, Bacterial / Q000302:isolation & purification; D059305:Diet, High-Fat / Q000009:adverse effects; D004731:Endotoxins / Q000097:blood; D005227:Fatty Acids / Q000008:administration & dosage; D005285:Fermentation; D005511:Food Handling; D000069196:Gastrointestinal Microbiome; D007422:Intestines / Q000382:microbiology; D007778:Lactobacillus / Q000302:isolation & purification; D020738:Leptin / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000178:diet therapy*; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D054392:Adipokines; D004269:DNA, Bacterial; D004731:Endotoxins; D005227:Fatty Acids; D020738:Leptin; D013662:Tea; D014280:Triglycerides; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase
keywords: Fuzhuan tea; Inflammation; Lactobacillus; Nonalcoholic fatty liver disease; Saturated fat