title: Whole-Body Vibration Partially Reverses Aging-Induced Increases in Visceral Adiposity and Hepatic Lipid Storage in Mice.
abstract: At old age, humans generally have declining muscle mass and increased fat deposition, which can increase the risk of developing cardiometabolic diseases. While regular physical activity postpones these age-related derangements, this is not always possible in the elderly because of disabilities or risk of injury. Whole-body vibration (WBV) training may be considered as an alternative to physical activity particularly in the frail population. To explore this possibility, we characterized whole-body and organ-specific metabolic processes in 6-month and 25-month old mice, over a period of 14 weeks of WBV versus sham training. WBV training tended to increase blood glucose turnover rates and stimulated hepatic glycogen utilization during fasting irrespective of age. WBV was effective in reducing white fat mass and hepatic triglyceride content only in old but not in young mice and these reductions were related to upregulation of hepatic mitochondrial uncoupling of metabolism (assessed by high-resolution respirometry) and increased expression of uncoupling protein 2. Because these changes occurred independent of changes in food intake and whole-body metabolic rate (assessed by indirect calorimetry), the liver-specific effects of WBV may be a primary mechanism to improve metabolic health during aging, rather than that it is a consequence of alterations in energy balance.
authors.affiliation: Groningen Institute for Evolutionary Life Sciences, Neurobiology, Unit of Behavioral Neurosciences, University of Groningen, Nijenborgh 7, NL-9747AG Groningen, The Netherlands.|Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9713GZ Groningen, The Netherlands.|Systems Biology Centre for Energy Metabolism and Ageing, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, NL-9713AV Groningen, The Netherlands.
authors.forename: Aaffien C
authors.initials: AC
authors.lastname: Reijne
authors.affiliation: Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9713GZ Groningen, The Netherlands.|Systems Biology Centre for Energy Metabolism and Ageing, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, NL-9713AV Groningen, The Netherlands.
authors.forename: Jolita
authors.initials: J
authors.lastname: Ciapaite
authors.affiliation: Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9700RB Groningen, The Netherlands.
authors.forename: Theo H
authors.initials: TH
authors.lastname: van Dijk
authors.affiliation: Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9713GZ Groningen, The Netherlands.
authors.forename: Rick
authors.initials: R
authors.lastname: Havinga
authors.affiliation: Groningen Institute for Evolutionary Life Sciences, Neurobiology, Unit of Molecular Neurobiology, University of Groningen, Nijenborgh 7, NL-9747AG Groningen, The Netherlands.
authors.forename: Eddy A
authors.initials: EA
authors.lastname: van der Zee
authors.affiliation: Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9713GZ Groningen, The Netherlands.|Systems Biology Centre for Energy Metabolism and Ageing, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, NL-9713AV Groningen, The Netherlands.
authors.forename: Albert K
authors.initials: AK
authors.lastname: Groen
authors.affiliation: Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9713GZ Groningen, The Netherlands.|Systems Biology Centre for Energy Metabolism and Ageing, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, NL-9713AV Groningen, The Netherlands.
authors.forename: Dirk-Jan
authors.initials: DJ
authors.lastname: Reijngoud
authors.affiliation: Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9713GZ Groningen, The Netherlands.|Systems Biology Centre for Energy Metabolism and Ageing, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, NL-9713AV Groningen, The Netherlands.
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Bakker
authors.affiliation: Groningen Institute for Evolutionary Life Sciences, Neurobiology, Unit of Behavioral Neurosciences, University of Groningen, Nijenborgh 7, NL-9747AG Groningen, The Netherlands.|ESRIG Center for Isotope Research, University of Groningen, Nijenborgh 4, NL-9747AG Groningen, The Netherlands.
authors.forename: Gertjan
authors.initials: G
authors.lastname: van Dijk
mesh_terms: D050154:Adiposity; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D002153:Calorimetry, Indirect; D050260:Carbohydrate Metabolism; D004734:Energy Metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008810:Mice, Inbred C57BL; D008930:Mitochondria, Liver / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D014732:Vibration; D014781:Viscera / Q000378:metabolism*
chemical_list: D001786:Blood Glucose