title: [Changes of brain pain center and default mode network an electro acupuncture in Weizhong and Dachangshu acupoints: a task-fMRI study].
abstract: OBJECTIVE
  To investigate the functional brain pain center and default mode network response to electro acupuncture stimulate in weizhong acupoints(BL40) and dachangshu acupoints(BL25).
  
  
  METHODS
  During January to February 2015, volunteers were enrolled in this study from the staff and student interns of Gansu Province Traditional Chinese Medicine Hospital. A total of 20 healthy, right-handed subjects, male 9, female 11, age (23±3) years, participated in this study. Block design task functional magnetic resonance imaging(fMRI) 3.0 T was performed in all subjects by electro acupuncture stimulating at BL40 and BL25 from the same experienced acupuncturist.The needle connected electric acupuncture apparatus through tow long coaxial-cable. A block design with five 120 s blocks of rest time (OFF block, electric acupuncture turn off ) interspersed between five 60 s blocks of stimulation (ON block, electric acupuncture turn on) fMRI scan. Magnetic resonance data of brain function was collected and FSL(fMRI Software Library) software was used to analyze the data.
  
  
  RESULTS
  All subjects' data were analyzed except 2 cases whose head movement were more than 2 mm. Activated brain function regions by electro acupuncture stimulate included temporal lobe lateral sulcus, lobus insularis, thalamus, supramarginal gyrus, prefrontal medial frontal gyrus. Negative activated brain regions included middle frontal gyrus, parahippocampal gyrus, cingulate cortex abdominal segment, parietal cortex.The functional pain central and default mode network were changed when electro acupuncture stimulate in(BL40) and(BL25).
  
  
  CONCLUSIONS
  There are several brain activation regions and negative activated brain regions when administering electro acupuncture stimulation at BL40 and BL25.
authors.affiliation: Department of Radiology, Gansu Province Hospital of Traditional Chinese Medicine, Lanzhou 730050, China.
authors.forename: S
authors.initials: S
authors.lastname: Zhou
authors.forename: H X
authors.initials: HX
authors.lastname: Cao
authors.forename: L C
authors.initials: LC
authors.lastname: Yu
authors.forename: Y J
authors.initials: YJ
authors.lastname: Jin
authors.forename: R H
authors.initials: RH
authors.lastname: Jia
authors.forename: Y R
authors.initials: YR
authors.lastname: Wen
authors.forename: X F
authors.initials: XF
authors.lastname: Chen
mesh_terms: D015669:Acupuncture Points; D001921:Brain; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010146:Pain; D018710:Pain Clinics; D010147:Pain Measurement; D055815:Young Adult