title: The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases.
abstract: The Na/K-ATPase has been extensively studied, but it is only recently that its role as a scaffolding and signaling protein has been identified. It has been identified that cardiotonic steroids (CTS) such as digitalis mediate signal transduction through the Na/K-ATPase in a process found to result in the generation of reactive oxygen species (ROS). As these ROS also appear capable of initiating this signal cascade, a feed forward amplification process has been postulated and subsequently implicated in some disease pathways including uremic cardiomyopathy.
authors.affiliation: Joan C. Edwards School of Medicine, Marshall University, Department of Medicine, USA.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Joan C. Edwards School of Medicine, Marshall University, Department of Medicine, USA. Electronic address: shapiroj@marshall.edu.
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Shapiro
mesh_terms: D000818:Animals; D002301:Cardiac Glycosides / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism*; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D002301:Cardiac Glycosides; D017382:Reactive Oxygen Species; D000254:Sodium-Potassium-Exchanging ATPase