title: Occurrence of Donor Cell-derived Lymphoid Blast Crisis 24 Years Following Related Bone Marrow Transplantation for Chronic Myeloid Leukemia.
abstract: We herein report a unique case of donor cell leukemia (DCL), as donor cell-derived lymphoid blast crisis of chronic myeloid leukemia (CML) was observed 24 years after related bone marrow transplantation for CML in the chronic phase. Short tandem repeat testing of the leukemic blast sample revealed full donor chimerism, strongly indicative of DCL. The original donor is healthy with a normal complete blood cell count for the past 24 years. This rare case may provide a precious opportunity to consider not only the underlying mechanism of DCL, but also the pathogenesis of CML.
authors.affiliation: Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Kurosawa
authors.forename: Noriko
authors.initials: N
authors.lastname: Doki
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Hino
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Fukushima
authors.forename: Naoki
authors.initials: N
authors.lastname: Shingai
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Hattori
authors.forename: Ken
authors.initials: K
authors.lastname: Watanabe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hagino
authors.forename: Aiko
authors.initials: A
authors.lastname: Igarashi
authors.forename: Yuho
authors.initials: Y
authors.lastname: Najima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kakihana
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sakamaki
authors.forename: Kazuteru
authors.initials: K
authors.lastname: Ohashi
mesh_terms: D000328:Adult; D001416:Back Pain / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D001752:Blast Crisis / Q000276:immunology / Q000473:pathology*; D001854:Bone Marrow Cells / Q000276:immunology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D020732:Cytogenetic Analysis; D005500:Follow-Up Studies; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D008297:Male; D013997:Time Factors