title: Endocannabinoids as Guardians of Metastasis.
abstract: Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and cancer pain. Recently we showed that the endocannabinoid profiles are deranged during cancer to an extent that this manifests in alterations of plasma endocannabinoids in cancer patients, which was mimicked by similar changes in rodent models of local and metastatic cancer. The present topical review summarizes the complexity of endocannabinoid signaling in the context of tumor growth and metastasis.
authors.affiliation: Institute of Clinical Pharmacology, University Hospital Frankfurt, Germany. tegeder@em.uni-frankfurt.de.
authors.forename: Irmgard
authors.initials: I
authors.lastname: Tegeder
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001095:Arachidonic Acids / Q000097:blood / Q000378:metabolism; D002186:Cannabinoids / Q000494:pharmacology / Q000627:therapeutic use; D063388:Endocannabinoids / Q000097:blood / Q000378:metabolism*; D019856:Ethanolamine / Q000378:metabolism; D005989:Glycerides / Q000097:blood / Q000378:metabolism; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D009829:Oleic Acids / Q000097:blood / Q000378:metabolism; D043882:Receptors, Cannabinoid / Q000378:metabolism; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents; D001095:Arachidonic Acids; D002186:Cannabinoids; D063388:Endocannabinoids; D005989:Glycerides; D009829:Oleic Acids; C440229:Oleylethanolamide; D043882:Receptors, Cannabinoid; D019856:Ethanolamine; C094503:glyceryl 2-arachidonate
keywords: 2-arachidonoylglycerol; anandamide; angiogenesis; endocannabinoids; immune cells; orphan G-protein coupled receptor