title: [Clinical analysis of grand glass opacity on CT as the first change of lung infection accompanied by hematologic malignancies].
abstract: OBJECTIVE
  To evaluate the value of grand glass opacity(GGO) on CT as a diagnostic sign of pulmonary fungal infection.
  
  
  METHODS
  The clinical data of 143 patients treated in department of hematology from January 2007 to June 2015 were analyzed retrospectively, and GGO or other attendant signs were observed.
  
  
  RESULTS
  The cases of fungal infection secondary to acute leukemia(AL), myelodysplastic syndromes(MDS), non-Hodgkin's lymphoma(NHL), multiple myeloma(MM), Hodgkin's lymphoma(HL) were 83, 23, 18, 10, 9, respectively, including 23 patients with hematopoietic stem cell transplantation.Ninety percent(128/143) of patients with GGO changes was accompanied with the presence of neutropenia.GGO was mostly accompanied by funicular inflammatory infiltrating shadows or nodules.The cases of possible invasive pulmonary fungal infections(IPFI), probable IPFI, proven IPFI, undefined IPFI were 56, 15, 4, 26, respectively.The total effective cases after anti-fungal therapy was 92.
  
  
  CONCLUSIONS
  Ground glass opacity as sign of pulmonary infection of CT mostly occurred in neutropenia and is more common in patients with acute leukemia or hematopoietic stem cell transplantation.GGO is a diagnostic sign of pulmonary fungal infection and it's indicating that anti-fungal medicine should be considered.
authors.affiliation: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450000, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Ruihua
authors.initials: R
authors.lastname: Mi
authors.forename: Xudong
authors.initials: X
authors.lastname: Wei
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Hao
authors.initials: H
authors.lastname: Ai
authors.forename: Fangfang
authors.initials: F
authors.lastname: Yuan
authors.forename: Qingsong
authors.initials: Q
authors.lastname: Yin
authors.forename: Yongping
authors.initials: Y
authors.lastname: Song
mesh_terms: D000208:Acute Disease; D019337:Hematologic Neoplasms; D006801:Humans; D008172:Lung Diseases, Fungal; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed