title: Photoacoustic elastography.
abstract: Elastography can noninvasively map the elasticity distribution in biological tissue, which can potentially be used to reveal disease conditions. In this Letter, we have demonstrated photoacoustic elastography by using a linear-array photoacoustic computed tomography system. The feasibility of photoacoustic elastography was first demonstrated by imaging the strains of single-layer and bilayer gelatin phantoms with various stiffness values. The measured strains agreed well with theoretical values, with an average error of less than 5.2%. Next, in vivo photoacoustic elastography was demonstrated on a mouse leg, where the fat and muscle distribution was mapped based on the elasticity contrast. We confirmed the photoacoustic elastography results by ultrasound elastography performed simultaneously.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Hai
authors.forename: Junjie
authors.initials: J
authors.lastname: Yao
authors.forename: Guo
authors.initials: G
authors.lastname: Li
authors.forename: Chiye
authors.initials: C
authors.lastname: Li
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
mesh_terms: D000818:Animals; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005780:Gelatin; D035002:Lower Extremity; D051379:Mice; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods*
chemical_list: D005780:Gelatin