title: Adverse effects of a 10-day course of ibuprofen in Holstein calves.
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended for various conditions in cattle. Ibuprofen is an inexpensive short-acting NSAID and is readily available in liquid formulation for administration to bottle-fed calves. We compared the adverse effects of a 10-day course of ibuprofen and placebo in 16 five- to six-week-old Holstein bull calves that were being treated for experimentally induced bovine respiratory syncytial virus infection. Ibuprofen was administered as a liquid in milk replacer at 30 mg/kg divided three times daily. We found an increased prevalence of abomasal ulceration 5 of 8 in the ibuprofen compared to placebo group 2 of 6 (P = NS). There was one (1 of 8) case of mild interstitial nephritis in the ibuprofen and none (0 of 8) in the placebo group (P = NS). Renal function as measured by serum BUN and creatinine levels was not different between groups; no animal demonstrated an increase in creatinine.
authors.affiliation: Pediatric Emergency Medicine, Sutter Medical Center, Sacramento, CA, USA.|Department of Emergency Medicine, University of California Davis, Sacramento, CA, USA.|Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
authors.forename: P
authors.initials: P
authors.lastname: Walsh
authors.affiliation: San Bernardino Branch, California Animal Health and Food Safety Laboratory, San Bernardino, CA, USA.
authors.forename: F R
authors.initials: FR
authors.lastname: Carvallo Chaigneau
authors.affiliation: California Animal Health and Food Safety Laboratory, Davis, CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Anderson
authors.affiliation: Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
authors.forename: N
authors.initials: N
authors.lastname: Behrens
authors.affiliation: Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
authors.forename: H
authors.initials: H
authors.lastname: McEligot
authors.affiliation: Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
authors.forename: B
authors.initials: B
authors.lastname: Gunnarson
authors.affiliation: Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Gershwin
mesh_terms: D000018:Abomasum / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001806:Blood Urea Nitrogen; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy; D003404:Creatinine / Q000097:blood; D004334:Drug Administration Schedule / Q000662:veterinary; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000662:veterinary; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy / Q000662:veterinary; D012136:Respiratory Syncytial Viruses; D013276:Stomach Ulcer / Q000139:chemically induced / Q000662:veterinary
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003404:Creatinine; D007052:Ibuprofen