title: Comparison of myocardial T1 and T2 values in 3 T with T2* in 1.5 T in patients with iron overload and controls.
abstract: Myocardial iron quantification remains limited to 1.5 T systems with T2* measurement. The present study aimed at comparing myocardial T2* values at 1.5 T to T1 and T2 mapping at 3.0 T in patients with iron overload and healthy controls. A total of 17 normal volunteers and seven patients with a history of myocardial iron overload were prospectively enrolled. Mid-interventricular septum T2*, native T1 and T2 times were quantified on the same day, using a multi-echo gradient-echo sequence at 1.5 T and T1 and T2 mapping sequences at 3.0 T, respectively. Subjects with myocardial iron overload (T2* < 20 ms) in comparison with those without had significantly lower mean myocardial T1 times (868.9 ± 120.2 vs. 1170.3 ± 25.0 ms P = 0.005 respectively) and T2 times (34.9 ± 4.7 vs. 45.1 ± 2.0 ms P = 0.007 respectively). 3 T T1 and T2 times strongly correlated with 1.5 T, T2* times (Pearson's r = 0.95 and 0.91 respectively). T1 and T2 measures presented less variability than T2* in inter- and intra-observer analysis. Native myocardial T1 and T2 times at 3 T correlate closely with T2* times at 1.5 T and may be useful for myocardial iron overload quantification.
authors.affiliation: Casa de Saúde São José, Rio de Janeiro, Brazil.|Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Gabriel C
authors.initials: GC
authors.lastname: Camargo
authors.affiliation: CDPI, Clinica de Diagnóstico por Imagem, Rio de Janeiro, Brazil.
authors.forename: Tamara
authors.initials: T
authors.lastname: Rothstein
authors.affiliation: CDPI, Clinica de Diagnóstico por Imagem, Rio de Janeiro, Brazil.|Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Flavia P
authors.initials: FP
authors.lastname: Junqueira
authors.affiliation: CDPI, Clinica de Diagnóstico por Imagem, Rio de Janeiro, Brazil.
authors.forename: Elsa
authors.initials: E
authors.lastname: Fernandes
authors.affiliation: Siemens AG, Healthcare Sector, Erlangen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Greiser
authors.affiliation: Siemens LTDA, São Paulo, Brazil.
authors.forename: Ralph
authors.initials: R
authors.lastname: Strecker
authors.affiliation: Hemorio, State Institute of Hematology, Rio de Janeiro, Brazil.
authors.forename: Viviani
authors.initials: V
authors.lastname: Pessoa
authors.affiliation: CDPI, Clinica de Diagnóstico por Imagem, Rio de Janeiro, Brazil.|Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Ronaldo S L
authors.initials: RS
authors.lastname: Lima
authors.affiliation: Casa de Saúde São José, Rio de Janeiro, Brazil. ilangottlieb@gmail.com.|National Institute of Cardiology, Rio de Janeiro, Brazil. ilangottlieb@gmail.com.
authors.forename: Ilan
authors.initials: I
authors.lastname: Gottlieb
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis*; D019190:Iron Overload / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results
chemical_list: D007501:Iron
keywords: 3 Tesla; Iron overload; Magnetic resonance; Parametric mapping