title: Efficacy and Safety of Therapeutic Endoscopic Retrograde Cholangiopancreatography in the Elderly Over 80 Years.
abstract: Concern regarding the safety and efficacy of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in elderly patients is increasing as a result of the aging society. However, there are limited data, especially in the super-aged elderly. This study aimed to evaluate the efficacy and safety of therapeutic ERCP in patients ≥80 years of age.
  
  
  
  Patients 80 years of age or older (n = 312) and younger than 65 years (n = 312) who underwent therapeutic ERCP from June 2006 to April 2014 were randomly selected and analyzed retrospectively. The main outcome measurements were therapeutic ERCP-related complications and clinical outcomes in the two groups.
  
  
  
  Choledocholithiasis combined with gallbladder stone was the most common indication for ERCP in both groups. Comorbid diseases (70.5 and 29.8 %, p < 0.001) and the use of anti-thrombotic drugs (18.6 and 1.6 %, p < 0.001) were more frequent in the super-aged group. The mean procedure time was longer, and the frequency of second ERCP was more common in the super-aged group. However, the technical success rate (94.9 and 97.4 %, p = 0.096) and the procedure-related complication rate (4.8 and 5.8 %, p = 0.592) were not different between the two groups. Post-ERCP pancreatitis occurred in 1.3 % of the super-aged group and in 2.9 % of the control group (p = 0.262). Cardiopulmonary complications occurred in 1.9 % of patients in each group (p = 1.0).
  
  
  
  Therapeutic ERCP is comparable in terms of efficacy and safety between patients ≥80 years and those <65 years of age, although the elderly group had a higher rate of comorbid diseases and used anti-thrombotic drugs more frequently.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Cheonan Hospital, Soonchunhyang University College of Medicine, 23-20 Bongmyung-Dong, Cheonan, Choongnam, 330-721, Republic of Korea.
authors.forename: Su Jung
authors.initials: SJ
authors.lastname: Han
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Cheonan Hospital, Soonchunhyang University College of Medicine, 23-20 Bongmyung-Dong, Cheonan, Choongnam, 330-721, Republic of Korea. thlee9@schmc.ac.kr.
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Lee
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Cheonan Hospital, Soonchunhyang University College of Medicine, 23-20 Bongmyung-Dong, Cheonan, Choongnam, 330-721, Republic of Korea.
authors.forename: Byong Il
authors.initials: BI
authors.lastname: Kang
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 14584, Republic of Korea.
authors.forename: Hyun Jong
authors.initials: HJ
authors.lastname: Choi
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 14584, Republic of Korea.
authors.forename: Yun Nah
authors.initials: YN
authors.lastname: Lee
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Seoul Hospital, Soonchunhyang University College of Medicine, 59, Daesagwan-ro, Yongsan-gu, Seoul, 140-887, Republic of Korea.
authors.forename: Sang-Woo
authors.initials: SW
authors.lastname: Cha
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 14584, Republic of Korea.
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Moon
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Seoul Hospital, Soonchunhyang University College of Medicine, 59, Daesagwan-ro, Yongsan-gu, Seoul, 140-887, Republic of Korea.
authors.forename: Young Deok
authors.initials: YD
authors.lastname: Cho
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Cheonan Hospital, Soonchunhyang University College of Medicine, 23-20 Bongmyung-Dong, Cheonan, Choongnam, 330-721, Republic of Korea.
authors.forename: Sang Hum
authors.initials: SH
authors.lastname: Park
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Cheonan Hospital, Soonchunhyang University College of Medicine, 23-20 Bongmyung-Dong, Cheonan, Choongnam, 330-721, Republic of Korea.
authors.forename: Sun-Joo
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000369:Aged, 80 and over; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects* / Q000379:methods*; D002764:Cholecystitis / Q000628:therapy; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000628:therapy; D012189:Retrospective Studies
keywords: Complications; Efficacy; Elderly; Endoscopic retrograde cholangiopancreatography; Safety