title: Enhanced-Resolution Optical Coherence Tomography Imaging.
abstract: OBJECTIVE
  The effect of the enhanced-resolution imaging (ERI) technique on optical coherence tomography (OCT) images was evaluated.
  
  
  METHODS
  A total of 5 healthy subjects and 20 patients diagnosed with various eye diseases were recruited into the study. ERI, a novel image processing technique, was accomplished by using super-resolution technology, and was assessed by objectively and subjectively comparing the image quality among three different image groups: images enlarged without bicubic interpolation (NONE), with bicubic interpolation (IP), and with ERI.
  
  
  RESULTS
  ERI showed a higher ratio of the detailed variance to the background variance than NONE, whereas no significant difference was detected between NONE and IP. The mean opinion score of 5 experienced retinal specialists for ERI was significantly higher than that for IP.
  
  
  CONCLUSIONS
  ERI generated a sharper image and clearly visualized small objects. Additionally, it is effective in enhancing OCT image quality.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Akihito
authors.initials: A
authors.lastname: Uji
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Murakami
authors.forename: Shigeta
authors.initials: S
authors.lastname: Arichika
authors.forename: Yuki
authors.initials: Y
authors.lastname: Muraoka
authors.forename: Shin
authors.initials: S
authors.lastname: Yoshitake
authors.forename: Yoko
authors.initials: Y
authors.lastname: Dodo
authors.forename: Nagahisa
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D003930:Diabetic Retinopathy / Q000000981:diagnostic imaging*; D003941:Diagnostic Techniques, Ophthalmological; D019773:Epiretinal Membrane / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008269:Macular Edema / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014607:Uveomeningoencephalitic Syndrome / Q000000981:diagnostic imaging*