title: The Evaluation of Serum Copeptin Levels and Some Commonly Seen Thrombophilic Mutation Prevalence in Acute Pulmonary Embolism.
abstract: Acute pulmonary embolism (PE) is a common, emergent condition and may affect a large number of patients. Copeptin has been indicated to be a sensitive biomarker of arginine vasopressin release, and has diagnostic and prognostic value in various clinical conditions. Genetic mutations are considerable components of thrombophilic diseases, and factor II gene G20210A, (FII20210A), factor V Leiden (FVL, G1691A) and methylenetetrahydrofolate reductase gene C677T (MTHFR677T) single nucleotide polymorphisms are the most common mutations of thrombophilic diseases. In this study, serum copeptin levels were determined in patients with PE and healthy controls, and the results were discussed. The prevalence of some commonly seen thrombophilic mutations was also evaluated in patients with PE. The study included 32 patients (18 male, 14 female) with PE and 24 (13 male, 11 female) age- and gender-matched healthy controls. A significant difference in serum copeptin levels was determined between the patient and control groups (8.58 ± 4.42 and 4.07 ± 1.02 pmol/L, respectively). Heterozygous mutant genotype for FII20210A and heterozygous mutant genotype for FVL were observed in 3.1 and 9.4% of patients, respectively. Mutant genotype of 49% was determined for MTHFR677T mutations. It was concluded that copeptin may have diagnostic value for PE.
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Ataturk University Research Hospital, Ataturk University Medical School, Ataturk University, 25070, Erzurum, Turkey. nurinnisa.ozturk@gmail.com.
authors.forename: Nurinnisa
authors.initials: N
authors.lastname: Ozturk
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Ataturk University Research Hospital, Ataturk University Medical School, Ataturk University, 25070, Erzurum, Turkey.
authors.forename: Nurcan Kilic
authors.initials: NK
authors.lastname: Baygutalp
authors.affiliation: Department of Emergency, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Atif
authors.initials: A
authors.lastname: Bayramoglu
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Ataturk University Research Hospital, Ataturk University Medical School, Ataturk University, 25070, Erzurum, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Polat
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Ataturk University Research Hospital, Ataturk University Medical School, Ataturk University, 25070, Erzurum, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Gul
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Ataturk University Research Hospital, Ataturk University Medical School, Ataturk University, 25070, Erzurum, Turkey.
authors.forename: Ebubekir
authors.initials: E
authors.lastname: Bakan
authors.affiliation: Department of Emergency, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Sahin
authors.initials: S
authors.lastname: Aslan
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Ataturk University Research Hospital, Ataturk University Medical School, Ataturk University, 25070, Erzurum, Turkey.
authors.forename: Ozge Nur
authors.initials: ON
authors.lastname: Gunes
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005165:Factor V / Q000235:genetics*; D005260:Female; D006020:Glycopeptides / Q000097:blood*; D006579:Heterozygote; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D015995:Prevalence; D011516:Prothrombin / Q000235:genetics*; D011655:Pulmonary Embolism / Q000097:blood / Q000235:genetics*
chemical_list: D006020:Glycopeptides; C048197:copeptins; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Acute pulmonary embolism; Biomarker; Copeptin; Thrombophilic mutations