title: Three New Cytotoxic Withanolides from the Chinese Folk Medicine Physalis angulata.
abstract: Physagulides M-O, three new withanolides (1-3), were isolated from the aerial parts of Physalis angulata L. Their structures were elucidated through extensive spectroscopic techniques, including 1D and 2D NMR, and HRESIMS. The absolute configurations (22-R) of these new compounds were determined by CD analysis. Compounds 1 and 3 showed significant selective cytotoxic activities on the MG-63 cell line, with IC50 values of 4.28 and 5.44 μM, respectively.
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Gao
authors.forename: Ting
authors.initials: T
authors.lastname: Ma
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D004365:Drugs, Chinese Herbal; D008958:Models, Molecular; D015394:Molecular Structure; D032321:Physalis / Q000737:chemistry*; D054358:Withanolides / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D054358:Withanolides