title: Higher plasma level of STIM1, OPG are correlated with stent restenosis after PCI.
abstract: OBJECTIVE
  Percutaneous Coronary Intervention (PCI) is one of the most effective treatments for Coronary Heart Disease (CHD), but the high rate of In Stent Restenosis (ISR) has plagued clinicians after PCI. We aim to investigate the correlation of plasma Stromal Interaction Molecular 1 (STIM1) and Osteoprotegerin (OPG) level with stent restenosis after PCI.
  
  
  METHODS
  A total of 100 consecutive patients with Coronary Heart Disease (CHD) received PCI procedure were recruited. Coronary angiography was performed 8 months after their PCI. Then patients were divided into 2 groups: observation group was composed by patients who existing postoperative stenosis after intervention; Control group was composed by patients with no postoperative stenosis. The plasma levels of STIM, OPG in all patients were tested before and after intervention. Pearson correlation and multiple linear regression analysis were performed to analysis the correlation between STIM, OPG level and postoperative stenosis.
  
  
  RESULTS
  35 cases were divided into observation group and other 65 were divided into control group. The plasma levels of STIM, OPG have no statistical difference before their PCI procedure, but we observed higher level of High-sensitivity C-reactive protein (Hs-CRP) existed in observation group. We observed higher level of plasma STIM, OPG in observation group when compared with control group after PCI procedure (P < 0.05). Regression analysis demonstrated that Hs-CRP, STIM1, OPG are independent risk factors for ISR.
  
  
  CONCLUSIONS
  Elevated levels of plasma STIM1, OPG are independent risk factors for ISR in patients received PCI, which could provide useful information for the restenosis control after PCI.
authors.affiliation: Department of Cardiology, Third Affiliated Hospital of Hebei Medical University Hebei, China.
authors.forename: Haibin
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Cardiology, Third Affiliated Hospital of Hebei Medical University Hebei, China.
authors.forename: Zhian
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of International Radiology, Third Affiliated Hospital of Hebei Medical University Hebei, China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Third Affiliated Hospital of Hebei Medical University Hebei, China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Yang
keywords: Percutaneous coronary intervention (PCI); high-sensitivity C-reactive protein (Hs-CRP); in stent restenosis (ISR); osteoprotegerin (OPG); stromal interaction molecular 1 (STIM1)