title: Study of the major essential oil compounds of Coriandrum sativum against Acinetobacter baumannii and the effect of linalool on adhesion, biofilms and quorum sensing.
abstract: Acinetobacter baumannii is a pathogen that has the ability to adhere to surfaces in the hospital environment and to form biofilms which are increasingly resistant to antimicrobial agents. The aim of this work was to study the antimicrobial activity of the major oil compounds of Coriandrum sativum against A. baumannii. The effect of linalool on planktonic cells and biofilms of A. baumannii on different surfaces, as well as its effect on adhesion and quorum sensing was evaluated. From all the compounds evaluated, linalool was the compound with the best antibacterial activity, with minimum inhibitory concentration values between 2 and 8 μl ml(-1). Linalool also inhibited biofilm formation and dispersed established biofilms of A. baumannii, changed the adhesion of A. baumannii to surfaces and interfered with the quorum- sensing system. Thus, linalool could be a promising antimicrobial agent for controlling planktonic cells and biofilms of A. baumannii.
authors.affiliation: a CICS-UBI - Health Sciences Research Centre , University of Beira Interior , Covilhã , Portugal.
authors.forename: Susana
authors.initials: S
authors.lastname: Alves
authors.affiliation: a CICS-UBI - Health Sciences Research Centre , University of Beira Interior , Covilhã , Portugal.
authors.forename: Andreia
authors.initials: A
authors.lastname: Duarte
authors.affiliation: b Fiber Materials and Environmental Technologies Research Unit , University of Beira Interior , Covilhã , Portugal.
authors.forename: Sónia
authors.initials: S
authors.lastname: Sousa
authors.affiliation: a CICS-UBI - Health Sciences Research Centre , University of Beira Interior , Covilhã , Portugal.
authors.forename: Fernanda C
authors.initials: FC
authors.lastname: Domingues
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology; D000080462:Acyclic Monoterpenes; D000268:Adhesiveness / Q000187:drug effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D028526:Coriandrum; D006801:Humans; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000494:pharmacology*; D009822:Oils, Volatile / Q000494:pharmacology; D010933:Plankton / Q000187:drug effects / Q000502:physiology; D053038:Quorum Sensing / Q000187:drug effects*
chemical_list: D000080462:Acyclic Monoterpenes; D000900:Anti-Bacterial Agents; D039821:Monoterpenes; D009822:Oils, Volatile; C018584:linalool
keywords: Acinetobacter baumannii; adhesion; biofilm; essential oil of Coriandrum sativum; linalool; quorum sensing