title: A hypothetical model of host-pathogen interaction of Streptococcus suis in the gastro-intestinal tract.
abstract: Streptococcus suis (SS) is a zoonotic pathogen that can cause systemic infection in pigs and humans. The ingestion of contaminated pig meat is a well-established risk factor for zoonotic S. suis disease. In our studies, we provide experimental evidence that S. suis is capable to translocate across the host gastro-intestinal tract (GIT) using in vivo and in vitro models. Hence, S. suis should be considered an emerging foodborne pathogen. In this addendum, we give an overview of the complex interactions between S. suis and host-intestinal mucosa which depends on the host origin, the serotype and genotype of S. suis, as well as the presence and expression of virulence factors involved in host-pathogen interaction. Finally, we propose a hypothetical model of S. suis interaction with the host-GIT taking in account differences in conditions between the porcine and human host.
authors.affiliation: a Department of Medical Microbiology ; Center for Infection and Immunity.|b Department of Global Health-Amsterdam Institute for Global Health and Development ; Academic Medical Center; University of Amsterdam , Amsterdam ( NL ).
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Ferrando
authors.affiliation: a Department of Medical Microbiology ; Center for Infection and Immunity.|b Department of Global Health-Amsterdam Institute for Global Health and Development ; Academic Medical Center; University of Amsterdam , Amsterdam ( NL ).
authors.forename: Constance
authors.initials: C
authors.lastname: Schultsz
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D013290:Streptococcal Infections / Q000382:microbiology*; D017011:Streptococcus suis / Q000235:genetics / Q000502:physiology*; D013552:Swine; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors
keywords: Streptococcus suis; zoonotic infection; gastro-intestinal infection; food-borne pathogen; intestinal translocation