title: Extranodal NK/T-cell lymphoma, nasal type of the uterine cervix: A case report.
abstract: We report a rare case of extranodal NK/T-cell lymphoma, nasal type of the uterine cervix that showed cytologic features mimicking cervical cancer. A 65-year-old woman presented with vaginal bleeding. Gynecological examination revealed a bulky tumor of the cervix. A conventional Papanicolaou-stained cervical smear showed hypercellularity consisting of numerous variably sized cohesive clusters that mimicked epithelial tumors, with a necrotic and inflammatory background. A small number of individually scattered cells were also identified. These scattered cells showed pleomorphic, often cleaved, or horseshoe-shaped nuclei and pale cytoplasm. Biopsy specimens revealed a diffuse growth of atypical cells with an angiocentric pattern. Extensive necrosis and infiltration of inflammatory cells were present. There were numerous mitotic figures. The tumor cells were positive for CD45RO, CD3ε, CD56, granzyme B, TIA-1, CD7, and Epstein-Barr virus (EBV)-encoded small RNA (EBER) by in situ hybridization, and negative for cytokeratin, chromogranin A, synaptophysin, CD4, CD5, CD8, CD20, and CD30. Based on these findings, this tumor was diagnosed as extranodal NK/T-cell lymphoma, nasal type of the uterine cervix.
authors.affiliation: Department of Obstetrics and Gynecology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Omori
authors.affiliation: Department of Pathology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Oishi
authors.affiliation: Department of Pathology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Tadao
authors.initials: T
authors.lastname: Nakazawa
authors.affiliation: Department of Pathology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nakazawa
authors.affiliation: Department of Hematology/Oncology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Mitsumori
authors.affiliation: Department of Pathology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yuminamochi
authors.affiliation: Department of Hematology/Oncology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Kirito
authors.affiliation: Department of Obstetrics and Gynecology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Hirata
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000378:metabolism / Q000473:pathology*; D065006:Papanicolaou Test; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology*; D014626:Vaginal Smears
chemical_list: D014408:Biomarkers, Tumor
keywords: T-cell and natural killer (NK) cell lymphoma; cytology; extranodal NK/T-cell lymphoma; female genital tract; malignant lymphoma; nasal type; uterine cervix