title: [66-year old female patient with vitreous and mucosal bleeding].
abstract: METHODS
  We report on a 66-year-old female patient, who presented with a new occurrence of mucosal bleeding and also developed a vitreous hemorrhage.
  
  
  METHODS
  The bleeding symptoms were caused by an acquired von Willebrand disease (VWD) associated with Waldenström macroglobulinemia. In this context, acquired VWD disease results from a dysfunction of the von Willebrand factor (VWF) caused by monoclonal immunoglobulin of type IgM.
  
  
  METHODS
  Chemotherapy led to normalization of VWF levels and activity, and a complete remission of the bleeding symptoms.
  
  
  CONCLUSIONS
  Acquired VWD should be considered in patients with acquired bleeding tendency. Vitreous hemorrhage as observed in our patient is an unusual bleeding symptom induced by hemorrhagic disorders and has to our knowledge not yet been reported in association with this entity.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Ackerstaff
authors.forename: Rita
authors.initials: R
authors.lastname: Dittmer
authors.forename: Christoph
authors.initials: C
authors.lastname: Sucker
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000009:adverse effects / Q000627:therapeutic use; D014823:Vitreous Hemorrhage; D014842:von Willebrand Diseases / Q000188:drug therapy*; D014841:von Willebrand Factor / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D014841:von Willebrand Factor