title: Global Progress and Challenges in Implementing New Medications for Treating Multidrug-Resistant Tuberculosis.
abstract: Two new drugs-bedaquiline and delamanid-have recently been approved by stringent regulatory authorities to treat multidrug-resistant tuberculosis (TB) and recommended by the World Health Organization for use under defined programmatic conditions. Introducing the medications in TB programs worldwide has not kept pace with the need for these drugs. In response, the DR-TB STAT (Drug-Resistant TB Scale-up Treatment Action Team) task force was formed in April 2015 to monitor progress and help overcome challenges. Information was collected from multiple sources and assessed monthly. Some progress has been made in introducing bedaquiline: as of October 2015, a total of 1,258 persons were on the medication under programmatic conditions. For delamanid, >100 patients, but few under programmatic conditions, have received the medication. Coordinated global action might help assist making these medications accessible for persons who need them most.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Furin
authors.forename: Grania
authors.initials: G
authors.lastname: Brigden
authors.forename: Erica
authors.initials: E
authors.lastname: Lessem
authors.forename: Michael
authors.initials: M
authors.lastname: Rich
authors.forename: Laura
authors.initials: L
authors.lastname: Vaughan
authors.forename: Sharonann
authors.initials: S
authors.lastname: Lynch
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D064687:Diarylquinolines / Q000627:therapeutic use*; D017277:Drug Approval; D006801:Humans; D009593:Nitroimidazoles / Q000627:therapeutic use*; D010080:Oxazoles / Q000627:therapeutic use*; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D064687:Diarylquinolines; D009593:Nitroimidazoles; C516022:OPC-67683; D010080:Oxazoles; C493870:bedaquiline
keywords: Mycobacterium tuberculosis and other mycobacteria; antimicrobial resistance; bacteria; bedaquiline; delamanid; drug-resistant TB; global progress