title: Satisfactory therapy results of combining nimustine with nicardipine against glioma at advanced stage.
abstract: Glioblastoma multiforme (GBM) is one of the most frequent brain cancers with a very poor prognosis. According to cancer stem cell (CSC) theory, therapies that are more specifically directed against CSCs might result in much more durable responses. Recently, we treated a case of GBM basing on the conception of CSC and gained a better clinic outcome. A 37-year-old male patient complained weakness of left limbs for 1 month. Magnetic resonance imaging (MRI) showed extensive lesions in the right hemisphere. We performed an intracranial tumor partial resection and the postoperative pathological diagnose was GBM. 1 month later, he received monthly chemotherapies with the combination of nimustine and nicardipine for totally 4 times. At the last chemotherapy, MRI scan showed the cancer almost completely disappeared with significantly improved clinic condition. The combination therapy of chemotherapeutics and nicardipine may be a promising treatment for patients of GBM at advanced stage.
authors.forename: Meiqing
authors.initials: M
authors.lastname: Lou
authors.affiliation: Department of Neurosurgery, Shanghai General Hospital, Shanghai; Department of Neurosurgery, Shang 10th People's Hospital, Shanghai, China.
authors.forename: Yaodong
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D009529:Nicardipine / Q000627:therapeutic use*; D015376:Nimustine / Q000627:therapeutic use*; D011379:Prognosis
chemical_list: D000959:Antihypertensive Agents; D000970:Antineoplastic Agents; D015376:Nimustine; D009529:Nicardipine