title: [Early Detection of Manganese Intoxication Based on Occupational History and T1-weighted MRI].
abstract: Manganese regulates many enzymes and is essential for normal cell function. Chronic manganese intoxication has an insidious and progressive course terminating to atypical parkinsonism with little therapeutic efficacy. For subjects with chronic manganese exposure such as welders, manganese intoxication can be detected early based on the presence of hyperintensity in the globus pallidus on T(1)-weighted MRI and abnormally high urinary excretion of manganese with a chelating agent even in cases of normal serum/urine level of manganese.
authors.affiliation: Department of Neurology, Kameda Medical Center.
authors.forename: Toshio
authors.initials: T
authors.lastname: Fukutake
authors.forename: Hajime
authors.initials: H
authors.lastname: Yano
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Kushida
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Sunada
mesh_terms: D001921:Brain / Q000473:pathology*; D042241:Early Diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008345:Manganese / Q000494:pharmacology*; D020149:Manganese Poisoning / Q000175:diagnosis / Q000473:pathology; D020734:Parkinsonian Disorders / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*
chemical_list: D008345:Manganese