title: Clinical Practices and Outcomes on Chemotherapy-Induced Nausea and Vomiting Management in South Korea: Comparison with Asia-Pacific Data of the Pan Australasian Chemotherapy Induced Emesis Burden of Illness Study.
abstract: OBJECTIVE
  This study reported patient outcomes of chemotherapy-induced nausea and vomiting (CINV) prophylaxis for highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC) regimens and evaluated its adherence to acute-phase CINV prophylaxis in the Korean population subset of the Pan Australasian Chemotherapy Induced Emesis burden of illness (PrACTICE) study.
  
  
  METHODS
  This subgroup analysis evaluated 158 Korean patients receiving HEC or MEC and compared the data (wherever possible) with that of 648 patients from the Asia-Pacific (AP) region. Study endpoints included evaluation of primary CINV prophylaxis and adherence to acute-phase CINV prophylaxis in cycle 1 (American Society of Clinical Oncology [ASCO] Quality Oncology Practice Initiative [QOPI]).
  
  
  RESULTS
  In South Korea and the AP, a 5-hydroxytryptamine-3 receptor antagonist (5HT3-RA) prophylaxis for the acute phase was administered to 79/80 patients (98.8%) for HEC and 70/71 patients (98.6%) for MEC regimens (QOPI-1). Triple regimen (corticosteroid-5HT3-RA-neurokinin 1-RA) was initiated in 46/80 patients (57.5%) for prophylaxis of acute CINV in cycle 1 of HEC (QOPI-3). Double regimen (corticosteroid-5HT3-RA, with or within NK1-RA) was initiated in 61/71 patients (83.1%) for control of acute CINV in cycle 1 of MEC a(QOPI-2).
  
  
  CONCLUSIONS
  Active management of CINV is necessary in cycle 1 of HEC in South Korea, despite higher rates than the AP region. Adherence to the international guidelines for CINV prophylaxis requires attention in the acute phase in cycle 1 of the HEC regimen.
authors.affiliation: Department of Internal Medicine, Seoul St. Mary's Hospital, Cancer Research Institution, The Catholic University of Korea, Seoul, Korea.
authors.forename: Myung Ah
authors.initials: MA
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Dong-A University Hospital, Busan, Korea.
authors.forename: Sung Yong
authors.initials: SY
authors.lastname: Oh
authors.affiliation: Department of Internal Medicine, Severance Hospital, Yonsei University, Seoul, Korea.
authors.forename: Joong Bae
authors.initials: JB
authors.lastname: Ahn
authors.affiliation: Merck Sharp and Dohme, Subsidiary of Merck and Co., Inc., Seoul, Korea.
authors.forename: Ji Yun
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Merck Sharp and Dohme, Subsidiary of Merck and Co., Inc., Seoul, Korea.
authors.forename: Burke
authors.initials: B
authors.lastname: Thomas
authors.affiliation: Merck Sharp and Dohme, Subsidiary of Merck and Co., Inc., Seoul, Korea.
authors.forename: Hun
authors.initials: H
authors.lastname: Jung
authors.affiliation: Department of Oncology/Hematology, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Jong Gwang
authors.initials: JG
authors.lastname: Kim
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use; D001208:Asia / Q000453:epidemiology; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D009325:Nausea / Q000139:chemically induced / Q000453:epidemiology* / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D056910:Republic of Korea / Q000453:epidemiology; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced / Q000453:epidemiology* / Q000473:pathology
chemical_list: D000932:Antiemetics; D058831:Serotonin 5-HT3 Receptor Antagonists
keywords: Antiemetics; Drug therapy; Nausea; Vomiting