title: Perinatal vitamin D levels are not associated with later risk of developing pediatric-onset inflammatory bowel disease: a Danish case-cohort study.
abstract: Objective Basic and epidemiologic studies on inflammatory bowel disease (IBD) have suggested an association between vitamin D and IBD risk. Though, the literature on IBD - especially pediatric-onset IBD - and vitamin D is still in its cradle. We therefore wanted to examine if levels of 25(OH)D at birth were associated with increased risk of developing pediatric-onset IBD. Material and methods A case-cohort study composed of cases diagnosed with Crohn's disease, ulcerative colitis or indeterminate/unclassified colitis and healthy controls. Cases and controls were matched on date of birth and were born in the period 1981-2004. Cases were diagnosed before the age of 18 years. The concentration of 25(OH)D was assessed from neonatal dried blood spots using a highly sensitive liquid chromatography tandem mass spectrometry. Odds ratios (OR) were calculated using conditional logistic regression and two-way ANOVA were used to test for season and birth year 25(OH)D variations. A total of 384 matched pairs were included in the statistical analyses. Results No significant association were found between levels of 25(OH)D and IBD risk in the adjusted model (OR [95% CI] (per 25 nmol/L increase), 1.12 [0.88; 1.42], p = 0.35). 25(OH)D levels were found to fluctuate significantly with season (p < 0.001) and year (p < 0.001). Median/Q1-Q3 values for 25(OH)D were 27.1/16.5-39.5 nmol/L for cases and 25.7/16.1-39.4 nmol/L for controls. Conclusion Our study do not suggest that a window of vulnerability exist around time of birth in regards to 25(OH)D levels and later pediatric-onset IBD risk.
authors.affiliation: a Department of Paediatrics, Copenhagen Diabetes Research Center (CPH-DIRECT) , Herlev University Hospital , Herlev , Denmark ;|b Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Steffen U
authors.initials: SU
authors.lastname: Thorsen
authors.affiliation: c Department of Paediatrics , Hvidovre University Hospital , Hvidovre , Denmark ;
authors.forename: Christian
authors.initials: C
authors.lastname: Jakobsen
authors.affiliation: d Department of Congenital Disorders , Statens Serum Institute , Copenhagen S , Denmark ;
authors.forename: Arieh
authors.initials: A
authors.lastname: Cohen
authors.affiliation: d Department of Congenital Disorders , Statens Serum Institute , Copenhagen S , Denmark ;
authors.forename: Marika
authors.initials: M
authors.lastname: Lundqvist
authors.affiliation: e National Institute of Public Health , University of Southern Denmark , Copenhagen K , Denmark ;
authors.forename: Lau C
authors.initials: LC
authors.lastname: Thygesen
authors.affiliation: f Department of Public Health, Section of Biostatistics , University of Copenhagen , Copenhagen K , Denmark ;
authors.forename: Christian
authors.initials: C
authors.lastname: Pipper
authors.affiliation: g Department of Nutrition , Harvard T.H. Chan School of Public Health , Boston , MA , USA.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ascherio
authors.affiliation: a Department of Paediatrics, Copenhagen Diabetes Research Center (CPH-DIRECT) , Herlev University Hospital , Herlev , Denmark ;
authors.forename: Jannet
authors.initials: J
authors.lastname: Svensson
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000097:blood; D003424:Crohn Disease / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015212:Inflammatory Bowel Diseases / Q000209:etiology*; D008297:Male; D053719:Tandem Mass Spectrometry; D014807:Vitamin D / Q000097:blood*
chemical_list: D014807:Vitamin D
keywords: Autoimmunity; epidemiology; inflammatory bowel diseases; vitamin D