title: An MRI-based classification scheme to predict passive access of 5 to 50-nm large nanoparticles to tumors.
abstract: Nanoparticles are useful tools in oncology because of their capacity to passively accumulate in tumors in particular via the enhanced permeability and retention (EPR) effect. However, the importance and reliability of this effect remains controversial and quite often unpredictable. In this preclinical study, we used optical imaging to detect the accumulation of three types of fluorescent nanoparticles in eight different subcutaneous and orthotopic tumor models, and dynamic contrast-enhanced and vessel size index Magnetic Resonance Imaging (MRI) to measure the functional parameters of these tumors. The results demonstrate that the permeability and blood volume fraction determined by MRI are useful parameters for predicting the capacity of a tumor to accumulate nanoparticles. Translated to a clinical situation, this strategy could help anticipate the EPR effect of a particular tumor and thus its accessibility to nanomedicines.
authors.affiliation: INSERM U823, Institut Albert Bonniot, Grenoble, France.|Université Joseph Fourier UJF, Grenoble, France.
authors.forename: Anastassia
authors.initials: A
authors.lastname: Karageorgis
authors.affiliation: INSERM U823, Institut Albert Bonniot, Grenoble, France.|Université Joseph Fourier UJF, Grenoble, France.|Nano-H S.A.S., Saint Quentin - Fallavier, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Dufort
authors.affiliation: INSERM U823, Institut Albert Bonniot, Grenoble, France.|Université Joseph Fourier UJF, Grenoble, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Sancey
authors.affiliation: INSERM U823, Institut Albert Bonniot, Grenoble, France.|Université Joseph Fourier UJF, Grenoble, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Henry
authors.affiliation: INSERM U1066, IBS-CHU, Angers, France.
authors.forename: Samuli
authors.initials: S
authors.lastname: Hirsjärvi
authors.affiliation: INSERM U1066, IBS-CHU, Angers, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Passirani
authors.affiliation: INSERM U1066, IBS-CHU, Angers, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Benoit
authors.affiliation: CEA-LETI MINATEC/DTBS, Grenoble, France.|Université Grenoble Alpes, Grenoble, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Gravier
authors.affiliation: CEA-LETI MINATEC/DTBS, Grenoble, France.|Université Grenoble Alpes, Grenoble, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Texier
authors.affiliation: Université Joseph Fourier UJF, Grenoble, France.|INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Montigon
authors.affiliation: INSERM U823, Institut Albert Bonniot, Grenoble, France.|Université Joseph Fourier UJF, Grenoble, France.
authors.forename: Mériem
authors.initials: M
authors.lastname: Benmerad
authors.affiliation: INSERM U823, Institut Albert Bonniot, Grenoble, France.|Université Joseph Fourier UJF, Grenoble, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Siroux
authors.affiliation: Université Joseph Fourier UJF, Grenoble, France.|INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France.
authors.forename: Emmanuel L
authors.initials: EL
authors.lastname: Barbier
authors.affiliation: INSERM U823, Institut Albert Bonniot, Grenoble, France.|Université Joseph Fourier UJF, Grenoble, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Coll
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media; D004195:Disease Models, Animal; D064593:Heterografts; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D010316:Particle Size; D010539:Permeability
chemical_list: D003287:Contrast Media; D008055:Lipids