title: Recurrent rhabdoid meningioma with lymph node, pulmonary and bone metastases: a diagnostic and therapeutic challenge.
abstract: Rhabdoid meningioma is a rare meningioma variant, classified as WHO grade III. Although this tumor is known for its aggressive behavior and poor prognosis, extracranial metastasis is rare. We report the rare case of a 31-year-old patient with rhabdoid meningioma which recurred several times despite gross total resection, radiation therapy, and gamma knife radiosurgery, and the last recurrence was associated with metastases to lungs, lymph node and bone. The patient showed no response to paclitaxel-carboplatin, or vincristine-cyclophosphamide-adriamycin chemotherapy, and succumbed to the disease. Metastases from rhabdoid meningioma prove to be a diagnostic challenge, and treatment for metastatic meningiomas is not optimized, thus necessitating documentation and interdisciplinary consensus on management protocols.
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Aanchal
authors.initials: A
authors.lastname: Kakkar
authors.affiliation: Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Saphalta
authors.initials: S
authors.lastname: Baghmar
authors.affiliation: Department of Neuroradiology, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Garg
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Vaishali
authors.initials: V
authors.lastname: Suri
authors.affiliation: Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Vinod
authors.initials: V
authors.lastname: Raina
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Chitra
authors.initials: C
authors.lastname: Sarkar
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India. sharmamehar@yahoo.co.in.
authors.forename: Mehar Chand
authors.initials: MC
authors.lastname: Sharma
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008579:Meningioma / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D009364:Neoplasm Recurrence, Local; D019635:Neurosurgical Procedures; D016634:Radiosurgery; D018714:Radiotherapy, Adjuvant
keywords: Immunohistochemistry; Lymph node; Meningioma; Metastases; Rhabdoid