title: DNA-Binding, Photocleavage, and Photodynamic Anti-cancer Activities of Pyridyl Corroles.
abstract: The DNA-binding, photocleavage, and antitumor activity of three free base pyridyl corroles 1, 2, and 3 have been investigated. The binding affinity toward CT-DNA decreases with increasing number of pentafluorophenyl, whereas the photocleavage activity toward pBR322 DNA becomes more efficient. Singlet oxygen was demonstrated as active species responsible for DNA cleavage. These corroles exhibited high cytotoxicity against three tested cancer cells (Hela, HapG2, and A549) and the cytotoxicity could be further enhanced under irradiation. Intracellular reactive oxygen species level was also monitored using HeLa Cells upon the combined treatment of corroles and light. These corroles could be absorbed by HeLa cells at low concentration. They can induce the decrease of mitochondrial membrane potential and apoptosis of tumor cells under irradiation.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China.
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Liang
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China. chhyliu@scut.edu.cn.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China.|Department of Chemistry and Bioengineering, Yichun University, Yichun, 336000, People's Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhou
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China.
authors.forename: Zao
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China.
authors.forename: Atif
authors.initials: A
authors.lastname: Ali
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China.
authors.forename: Bing-Jie
authors.initials: BJ
authors.lastname: Han
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China. lyjche@163.com.
authors.forename: Yun-Jun
authors.initials: YJ
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China. cexyxiao@scut.edu.cn.
authors.forename: Xin-Yan
authors.initials: XY
authors.lastname: Xiao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects* / Q000528:radiation effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008027:Light; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D015394:Molecular Structure; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D011166:Porphyrins; D017382:Reactive Oxygen Species; C431863:corrole; D004247:DNA
keywords: Apoptosis; Corrole; DNA; Photocytotoxicity; Reactive oxygen species