title: Abdominal obesity is strongly associated with Cardiovascular Disease and its Risk Factors in Elderly and very Elderly Community-dwelling Chinese.
abstract: Obesity is usually considered to predispose to atherosclerotic cardiovascular disease (ASCVD) but milder degrees of obesity or overweight may be protective in some elderly populations. We examined the relationships between general and abdominal obesity indices with ASCVD and its risk factors in elderly (aged ≥ 65 years) Shanghai community residents Among the 3950 participants, 21.5% had ASCVD, 56.2% had body mass index (BMI) ≥ 24 kg/m2, 50.1% had high waist circumference (WC) and 77.1% had waist-to-height ratio (WHtR) ≥ 0.50. WHtR increased with age in both men and women whereas WC increased with age only in women and BMI decreased with age only in men. The optimal WHtR cut-off value to predict the risk of ASCVD determined by receiver operating characteristic analysis was WHtR ≥ 0.53 with a prevalence of 55.8%. Having abdominal obesity was significantly associated with prevalent ASCVD with WHtR ≥ 0.53 having a higher value for the odds ratio than high WC, whereas high BMI was not associated. All three indices predicted high glucose, triglycerides and hsCRP levels but only the WHtR ≥ 0.53 showed a significant association with physical activity. Abdominal obesity indices, but not BMI, predicted prevalent ASCVD and its risk factors in this elderly Chinese population.
authors.affiliation: Research Center for Translational Medicine, Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Fan
authors.affiliation: Research Center for Translational Medicine, Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Li
authors.affiliation: Research Center for Translational Medicine, Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Research Center for Translational Medicine, Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Chen
authors.affiliation: Research Center for Translational Medicine, Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Lan
authors.affiliation: Gaohang Community Medical Center, 180 Gingao Road, Pudong New area, Shanghai, 200120, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.affiliation: Gaohang Community Medical Center, 180 Gingao Road, Pudong New area, Shanghai, 200120, China.
authors.forename: Xugang
authors.initials: X
authors.lastname: Ding
authors.affiliation: Gaohang Community Medical Center, 180 Gingao Road, Pudong New area, Shanghai, 200120, China.
authors.forename: Dingguang
authors.initials: D
authors.lastname: Qian
authors.affiliation: Research Center for Translational Medicine, Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Research Center for Translational Medicine, Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Zuoren
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Research Center for Translational Medicine, Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Lieying
authors.initials: L
authors.lastname: Fan
authors.affiliation: Research Center for Translational Medicine, Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Brian
authors.initials: B
authors.lastname: Tomlinson
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Paul
authors.initials: P
authors.lastname: Chan
authors.affiliation: Research Center for Translational Medicine, Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Research Center for Translational Medicine, Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000150:complications* / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D056128:Obesity, Abdominal / Q000150:complications* / Q000453:epidemiology*; D050177:Overweight / Q000150:complications / Q000453:epidemiology; D015995:Prevalence; D012372:ROC Curve; D018570:Risk Assessment; D012307:Risk Factors