title: The neutrophil-to-lymphocyte ratio in patients with obstructive sleep apnoea syndrome and its relationship with cardiovascular disease.
abstract: OBJECTIVE
  To investigate the association between the neutrophil-to-lymphocyte ratio (NLR) and obstructive sleep apnoea syndrome (OSAS) severity and whether the NLR predicts cardiovascular disease (CVD) in patients with OSAS.
  
  
  BACKGROUND
  OSAS is known as a risk factor for CVD. An increased NLR was strongly correlated with cardiovascular outcomes in several studies.
  
  
  METHODS
  We retrospectively examined the laboratory data for 289 patients with suspected OSAS evaluated using polysomnography.
  
  
  RESULTS
  The study included 171 OSAS patients and 118 controls. The NLR was higher in OSAS group than control group. The NLR was significantly higher in patients with CVD than in those without (3.31 ± 1.1 vs. 1.93 ± 0.8, p = 0.002). There were also significant correlations between the NLR and apnoea-hypopnoea index, mean SaO2, and oxygen desaturation index.
  
  
  CONCLUSIONS
  There was a significant correlation between the NLR and OSAS severity and the NLR was independently associated with CVD in patients with OSAS.
authors.affiliation: Bulent Ecevit University, Faculty of Medicine, Department of Pulmonary Medicine, Zonguldak, Turkey. Electronic address: dr.fuygur@hotmail.com.
authors.forename: Firat
authors.initials: F
authors.lastname: Uygur
authors.affiliation: Bulent Ecevit University, Faculty of Medicine, Department of Pulmonary Medicine, Zonguldak, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Tanriverdi
authors.affiliation: Bulent Ecevit University, Faculty of Medicine, Department of Cardiology, Zonguldak, Turkey.
authors.forename: Ziyaeddin
authors.initials: Z
authors.lastname: Aktop
authors.affiliation: Bulent Ecevit University, Faculty of Medicine, Department of Pulmonary Medicine, Zonguldak, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Erboy
authors.affiliation: Bulent Ecevit University, Faculty of Medicine, Department of Pulmonary Medicine, Zonguldak, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Altinsoy
authors.affiliation: Bulent Ecevit University, Faculty of Medicine, Department of Otolaryngology, Zonguldak, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Damar
authors.affiliation: Bulent Ecevit University, Faculty of Medicine, Department of Pulmonary Medicine, Zonguldak, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Atalay
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D017286:Polysomnography; D012189:Retrospective Studies; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications*
keywords: Apnoea-hypopnoea index; Cardiovascular disease; Inflammation; Neutrophil-to-lymphocyte ratio; Obstructive sleep apnoea syndrome