title: Preventing ventriculostomy-related infections with antibiotic-impregnated drains in hospitals: a two-centre Dutch study.
abstract: This observational cohort study assessed the effect of the introduction of antibiotic-impregnated external ventricular drains (AI-EVDs), as opposed to plain silicone EVDs, on the occurrence of ventriculostomy-related infections (VRIs) in two Dutch hospitals, with no other changes to their clinical practice. VRI was defined using the criteria of the Centers for Disease Control and Prevention, and with a culture-based definition. A propensity-score-adjusted competing risks survival analysis showed that introduction of AI-EVDs did not significantly decrease the risk of VRIs in routine care, nor affect the bacterial aetiology, even after adjustment for confounding and competing events.
authors.affiliation: Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: J D M
authors.initials: JDM
authors.lastname: Verberk
authors.affiliation: Department of Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Berkelbach van der Sprenkel
authors.affiliation: Department of Neurosurgery, Medisch Centrum Haaglanden, The Hague, The Netherlands.
authors.forename: M P
authors.initials: MP
authors.lastname: Arts
authors.affiliation: Department of Intensive Care, Medisch Centrum Haaglanden, The Hague, The Netherlands.
authors.forename: P J W
authors.initials: PJ
authors.lastname: Dennesen
authors.affiliation: Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands; Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: M J M
authors.initials: MJ
authors.lastname: Bonten
authors.affiliation: Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands. Electronic address: M.S.M.vanMourik-2@umcutrecht.nl.
authors.forename: M S M
authors.initials: MSM
authors.lastname: van Mourik
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D004322:Drainage / Q000379:methods*; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000517:prevention & control*; D016896:Treatment Outcome; D014696:Ventriculostomy / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotic-impregnated; Competing risks; External ventricular drains; Neurosurgery; Survival; Ventriculostomy-related infection