title: High-resolution manometry in patients with eosinophilic esophagitis under topical steroid therapy-a prospective observational study (HIMEOS-study).
abstract: BACKGROUND
  In eosinophilic esophagitis (EoE), dysphagia, which might reflect esophageal dysmotility, is the most common symptom. High-resolution manometry (HRM) has become widely accepted for evaluating esophageal motility disorders, but to date has been sparsely examined in EoE patients, particularly under therapy. The aim of this study was to evaluate HRM in symptomatic EoE-patients under topical steroid treatment.
  
  
  METHODS
  In this prospective observational study, symptomatic EoE patients received HRM-examinations before and after 8 weeks of topical steroid treatment with budesonide. All HRM-abnormalities were assessed and interpreted according to the Chicago classification. The primary endpoint was the influence of topical steroid treatment on the intrabolus pressure (IBP). Clinical symptoms, endoscopic findings and histological esophageal eosinophilic load were also reported.
  
  
  RESULTS
  Twenty symptomatic EoE patients were included. Overall success of budesonide therapy was 85% regarding complete histologic remission and 80% regarding complete clinical remission. High-resolution manometry showed abnormal esophageal motility in 35% of patients at baseline, which was resolved after therapy in 86% of these patients. Most frequent HRM-findings were early pan-esophageal pressurizations and weak persitalsis. There was no significant reduction of the IBP under therapy (before: 12.5 ± 4.9 mmHg, after: 10.9 ± 2.9 mmHg; p = 0.119).
  
  
  CONCLUSIONS
  Although dysphagia is the leading symptom of EoE, HRM is able to identify esophageal motility disorders in only some EoE patients. Observed motility disorders resolve after successful treatment in almost all of these patients. Intrabolus pressure does not seem an optimal parameter for the monitoring of successful treatment response in EoE patients.
authors.affiliation: II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Nennstiel
authors.affiliation: II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Bajbouj
authors.affiliation: II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Becker
authors.affiliation: Institut für Allgemeine Pathologie und Pathologische Anatomie der Technischen Universität München, München, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Slotta-Huspenina
authors.affiliation: Medizinische Fakultät der Universität des Saarlandes, Institut für Medizinische Biometrie, Epidemiologie und Medizinische Informatik (IMBEI), Homburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Wagenpfeil
authors.affiliation: II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
authors.forename: R M
authors.initials: RM
authors.lastname: Schmid
authors.affiliation: II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Schlag
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D019819:Budesonide / Q000627:therapeutic use; D057765:Eosinophilic Esophagitis / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods*; D011446:Prospective Studies
chemical_list: D000893:Anti-Inflammatory Agents; D019819:Budesonide
keywords: eosinophilic esophagitis; esophageal motility; high-resolution manometry