title: Outcomes of Bleomycin-based electrochemotherapy in patients with repeated loco-regional recurrences of vulvar cancer.
abstract: Objective To evaluate the safety, local tumor efficacy and relief of symptoms of electrochemotherapy (ECT) treatment in patients affected by recurrence of vulvar cancer (VC), unsuitable for standard treatments. Methods Ten patients were recruited with histological diagnosis of recurrence of VC. Intravenous bleomycin was injected, after an accurate mapping of all lesions and ECT was performed. Response to therapy was evaluated and quality of life (QoL) was evaluated via questionnaires. Results Diagnosis stage of primary tumors, according to the FIGO system, was: four patients respectively at stage IB (40%), and at stage II (40%), one patient at stage IIIA (10%), one patient with Paget cancer (10%). Mean age was 76 years (SD ± 7) at time of enrollment. Eight patients (80%) were previously submitted to surgery and/or radio-chemotherapy. Mean treatment time was 20 (range 10-20) min. After a median follow-up of 12 (3-22) months, six patients (60%) were alive. Conclusions Objective responses (ORs) with local control of the tumor were obtained in 80%. After a mean follow-up of 12 (3-22) months six patients (60%) were alive. The favorable outcome of this study, indicates that ECT is a reliable treatment option that may improve their functioning, thus enhancing the care provided in the palliative setting.
authors.affiliation: a Department of Obstetrics and Gynecology , Alessandro Manzoni Hospital , Lecco , Italy ;
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellegrino
authors.affiliation: a Department of Obstetrics and Gynecology , Alessandro Manzoni Hospital , Lecco , Italy ;|b Department of Obstetrics and Gynecology , Azienda Ospedaliera Di Lodi , Milan , Italy ;|c Department of dermatology , Alessandro Manzoni Hospital , Lecco , Italy ;|e Alessandro Manzoni Hospital , Lecco , Italy ;
authors.forename: Gianluca Raffaello
authors.initials: GR
authors.lastname: Damiani
authors.affiliation: a Department of Obstetrics and Gynecology , Alessandro Manzoni Hospital , Lecco , Italy ;
authors.forename: Costantino
authors.initials: C
authors.lastname: Mangioni
authors.affiliation: c Department of dermatology , Alessandro Manzoni Hospital , Lecco , Italy ;
authors.forename: Davide
authors.initials: D
authors.lastname: Strippoli
authors.affiliation: f Department of Obstetrics and Gynecology , University of Bari , Italy ;
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Loverro
authors.affiliation: d Department of Radiology, Alessandro Manzoni Hospital , Lecco , Italy ;
authors.forename: Antonio
authors.initials: A
authors.lastname: Cappello
authors.affiliation: e Alessandro Manzoni Hospital , Lecco , Italy ;
authors.forename: Daniela
authors.initials: D
authors.lastname: Turoli Scd
authors.affiliation: a Department of Obstetrics and Gynecology , Alessandro Manzoni Hospital , Lecco , Italy ;
authors.forename: Silvia
authors.initials: S
authors.lastname: Corso
authors.affiliation: f Department of Obstetrics and Gynecology , University of Bari , Italy ;
authors.forename: Massimo
authors.initials: M
authors.lastname: Tartagni
authors.affiliation: g Department of Pathology , Alessandro Manzoni Hospital , Lecco , Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Pezzotta
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D053672:Electrochemotherapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010166:Palliative Care / Q000379:methods*; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014846:Vulvar Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin