title: Management of Multiple Myeloma Complicated by Hepatitis C Virus Reactivation: The Role of New Antiviral Therapy.
abstract: Reactivation of chronic hepatitis C virus (HCV) infection has been reported in cancer patients receiving chemotherapy. In this study, we report the first case, to our knowledge, of thalidomide-induced acute exacerbation and reactivation of chronic HCV infection complicating management of multiple myeloma. Sofosbuvir-based antiviral therapy helped achieve viral clearance and normalization of liver enzymes, thus allowing access to future potentially life-saving chemotherapy agents.
authors.affiliation: Departments of Infectious Diseases, Infection Control, and Employee Health.
authors.forename: Parag
authors.initials: P
authors.lastname: Mahale
authors.affiliation: Lymphoma/Myeloma , The University of Texas MD Anderson Cancer Center , Houston, Texas.
authors.forename: Sheeba K
authors.initials: SK
authors.lastname: Thomas
authors.affiliation: Departments of Infectious Diseases, Infection Control, and Employee Health.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kyvernitakis
authors.affiliation: Departments of Infectious Diseases, Infection Control, and Employee Health.
authors.forename: Harrys A
authors.initials: HA
authors.lastname: Torres
keywords: hepatitis C virus; multiple myeloma; thalidomide; viral reactivation