title: Genetic association between hOGG1 C8069G polymorphism and colorectal cancer risk.
abstract: BACKGROUND
  hOGG1 C8069G polymorphism has been extensively investigated in single studies as well as meta-analyses in terms of the association with colorectal cancer (CRC). But the results remain contradictory. This study was undertaken to comprehensively evaluate the association of the commonly studied hOGG1 C8069G polymorphism and the susceptibility to CRC.
  
  
  METHODS
  By searching the electronic databases of PubMed, Embase, and Web of science, 16 available publications consisting of 4,866 cases and 7,363 controls were finally included in our meta-analysis. Stratified analyses by ethnicity and source of control were also carried out to further assess the association between hOGG1 C8069G polymorphism and CRC risk.
  
  
  RESULTS
  hOGG1 C8069G polymorphism was not observed to have statistical significance with the susceptibility to CRC (ORCC vs. GG = 0.97, 95% CI = 0.91-1.05; P = 0.995; ORCC + CG vs. GG = 0.98, 95% CI = 0.93-1.04; P = 0.993; ORCC vs. CG + GG = 0.96, 95% CI = 0.90-1.02; P = 0.339; ORallele C vs. allele G = 0.98, 95% CI = 0.94-1.02; P = 0.912; ORCG vs. GG = 0.95, 95% CI = 0.88-1.03; P = 0.526). Similarly, no association was found in the subgroup analysis by ethnicity or the source of control.
  
  
  CONCLUSIONS
  The results of our meta-analysis did not demonstrate any evidence for significant association between hOGG1 C8069G polymorphism and CRC risk. Future large-scale studies are expected to be conducted to further confirm our findings.
authors.affiliation: Department of Radiation Oncology, The Affiliated Hospital of Inner Mongolia Medical University Tongdao Road, Hohhot 10050, Inner Mongolia, P.R. China.
authors.forename: Xiaoge
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Radiation Oncology, Inner Mongolia Cancer Hospital & The Affiliated People's Hospital of Inner Mongolia Medical University Hohhot, Inner Mongolia, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Radiation Oncology, The Affiliated Hospital of Inner Mongolia Medical University Tongdao Road, Hohhot 10050, Inner Mongolia, P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Radiation Oncology, The Affiliated Hospital of Inner Mongolia Medical University Tongdao Road, Hohhot 10050, Inner Mongolia, P.R. China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Radiation Oncology, The Affiliated Hospital of Inner Mongolia Medical University Tongdao Road, Hohhot 10050, Inner Mongolia, P.R. China.
authors.forename: Yinna
authors.initials: Y
authors.lastname: Bao
authors.affiliation: Department of Radiation Oncology, The Affiliated Hospital of Inner Mongolia Medical University Tongdao Road, Hohhot 10050, Inner Mongolia, P.R. China.
authors.forename: Xiulan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, The Affiliated Hospital of Inner Mongolia Medical University Tongdao Road, Hohhot 10050, Inner Mongolia, P.R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Qi
authors.affiliation: Department of Radiation Oncology, The Affiliated Hospital of Inner Mongolia Medical University Tongdao Road, Hohhot 10050, Inner Mongolia, P.R. China.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, The Affiliated Hospital of Inner Mongolia Medical University Tongdao Road, Hohhot 10050, Inner Mongolia, P.R. China.
authors.forename: Congxiu
authors.initials: C
authors.lastname: Huang
authors.affiliation: Department of Radiation Oncology, The Affiliated Hospital of Inner Mongolia Medical University Tongdao Road, Hohhot 10050, Inner Mongolia, P.R. China.
authors.forename: Zhilong
authors.initials: Z
authors.lastname: Yu
keywords: C8069G; CRC; hOGG1; polymorphism; susceptibility