title: Quantitative agreement between [(15)O]H2O PET and model free QUASAR MRI-derived cerebral blood flow and arterial blood volume.
abstract: The purpose of this study was to assess whether there was an agreement between quantitative cerebral blood flow (CBF) and arterial cerebral blood volume (CBVA) measurements by [(15)O]H2O positron emission tomography (PET) and model-free QUASAR MRI. Twelve healthy subjects were scanned within a week in separate MRI and PET imaging sessions, after which quantitative and qualitative agreement between both modalities was assessed for gray matter, white matter and whole brain region of interests (ROI). The correlation between CBF measurements obtained with both modalities was moderate to high (r(2): 0.28-0.60, P < 0.05), although QUASAR significantly underestimated CBF by 30% (P < 0.001). CBVA was moderately correlated (r(2): 0.28-0.43, P < 0.05), with QUASAR yielding values that were only 27% of the [(15)O]H2O-derived values (P < 0.001). Group-wise voxel statistics identified minor areas with significant contrast differences between [(15)O]H2O PET and QUASAR MRI, indicating similar qualitative CBVA and CBF information by both modalities. In conclusion, the results of this study demonstrate that QUASAR MRI and [(15)O]H2O PET provide similar CBF and CBVA information, but with systematic quantitative discrepancies.
authors.affiliation: Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: D F R
authors.initials: DF
authors.lastname: Heijtel
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: E T
authors.initials: ET
authors.lastname: Petersen
authors.affiliation: Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: H J M M
authors.initials: HJ
authors.lastname: Mutsaerts
authors.affiliation: Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Bakker
authors.affiliation: Department of Anesthesiology, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Schober
authors.affiliation: Department of Anesthesiology, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: M F
authors.initials: MF
authors.lastname: Stevens
authors.affiliation: Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: B N M
authors.initials: BN
authors.lastname: van Berckel
authors.affiliation: Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: C B L M
authors.initials: CB
authors.lastname: Majoie
authors.affiliation: Department of Nuclear Medicine, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Booij
authors.affiliation: C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
authors.forename: M J P
authors.initials: MJ
authors.lastname: van Osch
authors.affiliation: Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: E T
authors.initials: ET
authors.lastname: van Bavel
authors.affiliation: Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Boellaard
authors.affiliation: Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: A A
authors.initials: AA
authors.lastname: Lammertsma
authors.affiliation: Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Nederveen
mesh_terms: D000328:Adult; D001158:Arteries / Q000502:physiology*; D001810:Blood Volume / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010103:Oxygen Isotopes; D049268:Positron-Emission Tomography / Q000379:methods*; D014867:Water / Q000378:metabolism*; D055815:Young Adult
chemical_list: D010103:Oxygen Isotopes; D014867:Water
keywords: ASL; PET; arterial blood volume; cerebral blood flow; quasar