title: Marine cytotoxic jaspine B and its stereoisomers: biological activity and syntheses.
abstract: Conformationally constrained sphingolipids such as anhydrophytosphingosines represented by jaspine B (also known as pachastrissamine) and its stereoisomers have become an attractive and timely target for total synthesis due to their significant biological activity as well as the unique structures. This review article describes the biological activity and chemistry of the natural jaspine B and its seven stereoisomers.
authors.affiliation: Institute of Chemical Sciences, Department of Organic Chemistry, P. J. Šafárik University, Moyzesova 11, Sk-040 01 Košice, Slovak Republic. Electronic address: miroslava.martinkova@upjs.sk.
authors.forename: Miroslava
authors.initials: M
authors.lastname: Martinková
authors.affiliation: Institute of Chemical Sciences, Department of Organic Chemistry, P. J. Šafárik University, Moyzesova 11, Sk-040 01 Košice, Slovak Republic.
authors.forename: Jozef
authors.initials: J
authors.lastname: Gonda
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D003603:Cytotoxins; C468594:pachastrissamine; D013110:Sphingosine
keywords: Anhydrophytosphingosines; Asymmetric synthesis; Cytotoxic activity; Jaspine B; Sphingolipids; Stereoselective synthesis