title: Enoxaparin has no significant anticoagulation activity in healthy Beagles at a dose of 0.8 mg/kg four times daily.
abstract: Enoxaparin at 0.8 mg/kg every 6 h is used in dogs to prevent prothrombotic events, but has only been validated in healthy Greyhounds, a breed with documented hypocoagulable haemostatic profiles in vitro and bleeding tendencies in vivo. This study investigated the effects of enoxaparin at this dose rate on the coagulation parameters of eight healthy adult Beagles over a 48 h period. Anti-Xa activity was significantly increased 3 h after the second and third of nine injections, and target anti-Xa activity was only reached transiently in 3/8 dogs. Paradoxically, a transient increase in endogenous thrombin potential was observed 6 h after the third injection. Other haematologic, biochemical and coagulation parameters were not significantly altered from the baseline values during enoxaparin treatment (P > 0.05). This study suggests that assumptions regarding the pharmacodynamic effects of enoxaparin are not generalisable across breeds.
authors.affiliation: Intensive Care Unit (SIAMU), VetAgro Sup campus vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France; EA4174 Sepsis, Inflammation, Hémostase, VetAgro Sup campus vétérinaire de Lyon, Université de Lyon, France; APCSe Agressions Pulmonaires et Circulatoires dans le Sepsis, Marcy l'Etoile, France. Electronic address: celine.pouzotnevoret@vetagro-sup.fr.
authors.forename: Céline
authors.initials: C
authors.lastname: Pouzot-Nevoret
authors.affiliation: Intensive Care Unit (SIAMU), VetAgro Sup campus vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France; EA4174 Sepsis, Inflammation, Hémostase, VetAgro Sup campus vétérinaire de Lyon, Université de Lyon, France; APCSe Agressions Pulmonaires et Circulatoires dans le Sepsis, Marcy l'Etoile, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Barthélemy
authors.affiliation: Intensive Care Unit (SIAMU), VetAgro Sup campus vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France; EA4174 Sepsis, Inflammation, Hémostase, VetAgro Sup campus vétérinaire de Lyon, Université de Lyon, France.
authors.forename: Marianne
authors.initials: M
authors.lastname: Cluzel
authors.affiliation: Intensive Care Unit (SIAMU), VetAgro Sup campus vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France; Critical and Intensive Care and Anaesthesia, Veterinary School of Toulouse, Toulouse, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Verwaerde
authors.affiliation: EA4174 Sepsis, Inflammation, Hémostase, VetAgro Sup campus vétérinaire de Lyon, Université de Lyon, France; APCSe Agressions Pulmonaires et Circulatoires dans le Sepsis, Marcy l'Etoile, France.
authors.forename: Jeanne-Marie
authors.initials: JM
authors.lastname: Bonnet-Garin
authors.affiliation: Intensive Care Unit (SIAMU), VetAgro Sup campus vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France; EA4174 Sepsis, Inflammation, Hémostase, VetAgro Sup campus vétérinaire de Lyon, Université de Lyon, France; APCSe Agressions Pulmonaires et Circulatoires dans le Sepsis, Marcy l'Etoile, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Goy-Thollot
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D017984:Enoxaparin / Q000494:pharmacology*; D008297:Male
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin
keywords: Anticoagulation; Dog; Enoxaparin; Low-molecular-weight heparin; Thromboelastometry