title: Antioxidant and hyaluronidase inhibitory activities of diverse phenolics in Phyllanthus emblica.
abstract: Fifty-eight phenolic compounds isolated from Phyllanthus emblica were screened and compared for their in vitro and in vivo antioxidant properties, as well as hyaluronidase (HAase) inhibitory activities. Among them, 20 compounds showed to be promising antioxidants due to the stronger scavenging activity in both DPPH radical and Danio rerio reactive oxygen species assays, while nine compounds were potential HAase inhibitors with 100-fold stronger activities than that of the positive control, DSCG. The structure activity relationship was discussed.
authors.affiliation: a State Key Laboratory of Phytochemistry & Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: a State Key Laboratory of Phytochemistry & Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , People's Republic of China.
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Zhu
authors.affiliation: a State Key Laboratory of Phytochemistry & Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , People's Republic of China.
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: Cheng
authors.affiliation: a State Key Laboratory of Phytochemistry & Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , People's Republic of China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Phytochemistry & Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , People's Republic of China.
authors.forename: Chong-Ren
authors.initials: CR
authors.lastname: Yang
authors.affiliation: b Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: b Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Kouno
authors.affiliation: a State Key Laboratory of Phytochemistry & Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , People's Republic of China.
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Zhang
keywords:  ROS-scavenging activity; DPPH radical; HAase inhibition; antioxidant; phenolics