title: Construction and analysis of cardiac hypertrophy-associated lncRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in cardiac hypertrophy.
abstract: Cardiac hypertrophy (CH) could increase cardiac after-load and lead to heart failure. Recent studies have suggested that long non-coding RNA (lncRNA) played a crucial role in the process of the cardiac hypertrophy, such as Mhrt, TERMINATOR. Some studies have further found a new interacting mechanism, competitive endogenous RNA (ceRNA), of which lncRNA could interact with micro-RNAs (miRNA) and indirectly interact with mRNAs through competing interactions. However, the mechanism of ceRNA regulated by lncRNA in the CH remained unclear. In our study, we generated a global triple network containing mRNA, miRNA and lncRNA, and extracted a CH related lncRNA-mRNA network (CHLMN) through integrating the data from starbase, miRanda database and gene expression profile. Based on the ceRNA mechanism, we analyzed the characters of CHLMN and found that 3 lncRNAs (SLC26A4-AS1, RP11-344E13.3 and MAGI1-IT1) were high related to CH. We further performed cluster module analysis and random walk with restart for the CHLMN, finally 14 lncRNAs had been discovered as the potential CH related disease genes. Our results showed that lncRNA played an important role in the CH and could shed new light to the understanding underlying mechanisms of the CH.
authors.affiliation: Department of Pharmacology, Harbin Medical University-Daqing, Daqing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Song
authors.affiliation: Department of Medical Informatics, Harbin Medical University-Daqing, Daqing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, Harbin Medical University-Daqing, Daqing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Pharmacology, Harbin Medical University-Daqing, Daqing, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Pan
authors.affiliation: Department of Pharmacology, Harbin Medical University-Daqing, Daqing, China.
authors.forename: Han-Ping
authors.initials: HP
authors.lastname: Qi
authors.affiliation: Department of Pharmacology, Harbin Medical University-Daqing, Daqing, China.
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Cao
authors.affiliation: Department of Medical Informatics, Harbin Medical University-Daqing, Daqing, China.
authors.forename: Jian-Mei
authors.initials: JM
authors.lastname: Zhao
authors.affiliation: Department of Medical Informatics, Harbin Medical University-Daqing, Daqing, China.
authors.forename: Shang
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Pharmacology, Harbin Medical University-Daqing, Daqing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Pharmacology, Harbin Medical University-Daqing, Daqing, China.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Sun
authors.affiliation: Department of Medical Informatics, Harbin Medical University-Daqing, Daqing, China.
authors.forename: Chun-Quan
authors.initials: CQ
authors.lastname: Li
mesh_terms: D006332:Cardiomegaly / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D006801:Humans; D008957:Models, Genetic; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism
chemical_list: D062085:RNA, Long Noncoding; D012333:RNA, Messenger
keywords: Pathology Section; cardiac hypertrophy; ceRNA; gene expression profile; lncRNA; network analysis