title: Synthesis of 9-Substituted Triptycene Building Blocks for Solid-Phase Diversification and Nucleic Acid Junction Targeting.
abstract: Triptycenes have been shown to bind nucleic acid three-way junctions, but rapid and efficient methods to diversify the triptycene core are lacking. An efficient synthesis of a 9-substituted triptycene scaffold is reported that can be used as a building block for solid-phase peptide synthesis and rapid diversification. The triptycene building block was diversified to produce a new class of tripeptide-triptycenes, and their binding abilities toward d(CAG)·(CTG) repeat junctions were investigated.
authors.affiliation: Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Ina
authors.initials: I
authors.lastname: Yoon
authors.affiliation: Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Sung-Eun
authors.initials: SE
authors.lastname: Suh
authors.affiliation: Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Barros
authors.affiliation: Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States.
authors.forename: David M
authors.initials: DM
authors.lastname: Chenoweth
mesh_terms: D000873:Anthracenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009696:Nucleic Acids / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques
chemical_list: D000873:Anthracenes; D009696:Nucleic Acids; D009838:Oligodeoxyribonucleotides; C520712:triptycene