title: Calcification around the Struts of a Sirolimus-eluting Stent Approximately 16 Months after Implantation in an Autopsy Case.
abstract: Drug-eluting stents (DES) are widely used for the treatment of coronary artery disease, and a sirolimus-eluting stent (SES; Cypher) was the first DES introduced into clinical practice. Although pathological reactions of coronary arteries to SES have been described in autopsy cases, there are few reports regarding calcification of the coronary arteries after SES implantation. The present report describes the findings of an autopsy conducted 16 months after SES implantation that showed remarkable persistent calcification. In addition, previously reported pertinent pathological findings are also described.
authors.affiliation: Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawano
authors.forename: Katsumi
authors.initials: K
authors.lastname: Inoue
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Osami
authors.initials: O
authors.lastname: Sato
authors.forename: Shuji
authors.initials: S
authors.lastname: Arakawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakatomi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yamasa
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Aoki
authors.forename: Koji
authors.initials: K
authors.lastname: Maemura
mesh_terms: D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D001344:Autopsy; D002114:Calcinosis / Q000150:complications / Q000473:pathology*; D003324:Coronary Artery Disease / Q000473:pathology* / Q000628:therapy; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006323:Heart Arrest / Q000209:etiology / Q000473:pathology*; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D020123:Sirolimus / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D020123:Sirolimus