title: Setting up an outpatient parenteral antimicrobial therapy (OPAT) unit in Switzerland: review of the first 18 months of activity.
abstract: Outpatient parenteral antimicrobial therapy (OPAT) has been recognised as a useful, cost-effective and safe alternative to inpatient treatment, but no formal OPAT unit existed in Switzerland until recently. In December 2013 an OPAT unit was established at Lausanne University Hospital. We review here the experience of this new OPAT unit after 18 months of activity. Patient characteristics, clinical activities and outcomes were recorded prospectively. Need and acceptance was evaluated as number of OPAT courses administered and number of patients refusing OPAT. Safety and efficacy were evaluated as: (1) adverse events linked to antimicrobials and catheters, (2) re-admission to hospital, (3) rate of treatment failures and (4) mortality. Over 18 months, 179 courses of OPAT were administered. Acceptance was high with only four patients refusing OPAT. Urinary tract infections with resistant bacteria and musculoskeletal infections were the most common diagnoses. Self-administration of antibiotics using elastomeric pumps became rapidly the most frequently used approach. Sixteen patients presented with adverse events linked to antimicrobials and catheters. OPAT-related readmissions occurred in nine patients. The overall cure rate was 94 %. This study shows that OPAT is very well accepted by patients and medical staff, even in a setting which has not used this type of treatment approach until now. Self-administration using elastomeric pumps proved to be particularly useful, safe and efficient. OPAT offers a good alternative to hospitalisation for patients presenting with infections due to resistant bacteria that cannot be treated orally anymore and for difficult to treat infections.
authors.affiliation: Service of Infectious Diseases, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, 1011, Lausanne, Switzerland. celine.gardiol@chuv.ch.
authors.forename: C
authors.initials: C
authors.lastname: Gardiol
authors.affiliation: Service of Internal Medicine, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Voumard
authors.affiliation: Department of Outpatient Care and Community Medicine, Rue du Bugnon 44, 1011, Lausanne, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Cochet
authors.affiliation: Service of Infectious Diseases, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, 1011, Lausanne, Switzerland.|Department of Outpatient Care and Community Medicine, Rue du Bugnon 44, 1011, Lausanne, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: de Vallière
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013557:Switzerland / Q000453:epidemiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents