title: Potentiation ofFrancisellaResistance to Conventional Antibiotics through Small Molecule Adjuvants.
abstract: A screen of 20 compounds identified small molecule adjuvants capable of potentiating anitbiotic activty againstFrancisella philomiragia. Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containg an indole core. The lead compound was able to lower the MIC of colistin by 32-fold against intrinsically resistantF. philomiragia.
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Stephens
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
authors.forename: Veroncia B
authors.initials: VB
authors.lastname: Hubble
authors.affiliation: Department of Microbial Pathogenesis, University of Maryland - Baltimore, Baltimore, MD 21201, United States.
authors.forename: Robert K
authors.initials: RK
authors.lastname: Ernst
authors.affiliation: School of Systems Biology & National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, United States.
authors.forename: Monique L
authors.initials: ML
authors.lastname: van Hoek
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
authors.forename: Roberta J
authors.initials: RJ
authors.lastname: Melander
authors.affiliation: Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
authors.forename: John
authors.initials: J
authors.lastname: Cavanagh
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
authors.forename: Christian
authors.initials: C
authors.lastname: Melander