title: Preparation of aqueous alpha-lipoic acid dispersions with octenylsuccinylated high amylose starch.
abstract: Aqueous dispersions prepared with OSA-modified high amylose starch were investigated in comparison with native high amylose starch and beta-cyclodextrin using alpha-lipoic acid as a model substance. Alpha-lipoic acid (ALA), a lipophilic antioxidant essential for energy metabolism in human, was dispersed in gelatinized starch solutions (1.0% w/v) at different temperatures (50-90°C) and times (3-12h). High amylose starch modified with 3% OSA (dry starch base) was most favored in maximizing the dispersibility of ALA (84% recovery) under mild heating (70°C for 3h). The optimally prepared dispersion was milky white and contained particles with a narrow size distribution (200-300nm). The precipitate isolated from the dispersion contained crystalline V-complexes of ALA and amylose while the supernatant contained free ALA accounting for 1/3 of total ALA, indicating OSA-modified high amylose starch stabilized ALA either by complexing with amylose or by retarding aggregation of ALA.
authors.affiliation: Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea.
authors.forename: Yi-Xuan
authors.initials: YX
authors.lastname: Li
authors.affiliation: Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea. Electronic address: limst@korea.ac.kr.
authors.forename: Seung-Taik
authors.initials: ST
authors.lastname: Lim
mesh_terms: D000688:Amylose / Q000737:chemistry*; D004355:Drug Stability; D013386:Succinates / Q000737:chemistry*; D013696:Temperature; D008063:Thioctic Acid / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D013386:Succinates; D047392:beta-Cyclodextrins; C028480:octenyl succinate; D008063:Thioctic Acid; D000688:Amylose
keywords: Alpha-lipoic acid; High amylose starch; Nano-dispersion; Octenylsuccinylated starch; V-complex