title: Estrogen repression of microRNA as a potential cause of cancer.
abstract: MicroRNAs (miRNAs) are endogenous small molecules that regulate gene expression and have been implicated in the pathogenesis of many human diseases, including cancer. This review describes the results that show a global repression in miRNA expression in various tumors and cancer cell lines. Intriguingly, recent discoveries have shown a widespread downregulation of miRNA after exposure to the steroid hormone estrogen. The integration of the results suggests that estrogen-dependent repression of miRNA is a potential cause of cancer.
authors.affiliation: Genomic Data Analysis Unit, The Hebrew University of Jerusalem-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel.
authors.forename: Amit
authors.initials: A
authors.lastname: Cohen
authors.affiliation: Centro de Investigaciones Biolόgicas del Noroeste, S.C. Mar Bermejo 195, Col. Playa Palo de Sta. Rita, La Paz, BCS, 23090, México. Electronic address: marioburgos21@hotmail.com.
authors.forename: Mario Alberto
authors.initials: MA
authors.lastname: Burgos-Aceves
authors.affiliation: Genomic Data Analysis Unit, The Hebrew University of Jerusalem-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel.
authors.forename: Yoav
authors.initials: Y
authors.lastname: Smith
mesh_terms: D004967:Estrogens / Q000378:metabolism* / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics*; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
chemical_list: D004967:Estrogens; D035683:MicroRNAs
keywords: Cancer; Estrogen; microRNA