title: Head-To-Head Comparison of Two Years Efficacy of Entecavir and Tenofovir in Patients with Treatment-Naïve Chronic Hepatitis B--The Real Life Data.
abstract: OBJECTIVE
  Entecavir and tenofovir are generally accepted as first-line therapeutic options in chronic hepatitis B. Both of them are potent and have high genetic barrier to viral resistance. Aim of this study was to compare the two-year efficacy of entecavir and tenofovir in treatment-naive chronic hepatitis B patients.
  
  
  METHODS
  Study was comprised 164 patients with treatment naïve chronic hepatitis or compensated liver cirrhosis. At least twenty four mouths of entecavir or tenofovir were given to all patients.
  
  
  RESULTS
  Mean ALT levels, ALT normalization rates, mean HBV DNA levels, HBV DNA negativity rates and HBeAg negativity rates were not different in entecavir and tenofovir groups throughout the study. Mean serum creatinine levels were also similar between groups.
  
  
  CONCLUSIONS
  Two-years of antiviral treatment of treatment-naïve patients with chronic hepatitis B or cirrhosis with entecavir or tenofovir were equally effective.
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D000068698:Tenofovir / Q000627:therapeutic use*; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D006513:Hepatitis B e Antigens; C413685:entecavir; D006147:Guanine; D000068698:Tenofovir; D000410:Alanine Transaminase