title: Back to the future: bacteriophages as promising therapeutic tools.
abstract: Bacteriophages (phages), natural predators of bacteria, are becoming increasingly attractive in medical and pharmaceutical applications. After their discovery almost a century ago, they have been particularly instrumental in the comprehension of basic molecular biology and genetics processes. The more recent emergence of multi-drug-resistant bacteria requires novel therapeutic strategies, and phages are being (re)considered as promising potential antibacterial tools. Furthermore, phages are also used for other purposes, e.g. vaccine production, gene/drug carriers, bacterial detection and typing. These new alternative approaches using phages are of major interest and have allowed unexpected developments, from the decipherment of fundamental biological processes to potential clinical applications.
authors.affiliation: Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx Transplantex, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.|Fédération Hospitalo-Universitaire OMICARE, Centre de Recherche d'Immunologie et d'Hématologie, Strasbourg, France.
authors.forename: P
authors.initials: P
authors.lastname: Domingo-Calap
authors.affiliation: Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx Transplantex, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.|Fédération Hospitalo-Universitaire OMICARE, Centre de Recherche d'Immunologie et d'Hématologie, Strasbourg, France.
authors.forename: P
authors.initials: P
authors.lastname: Georgel
authors.affiliation: Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx Transplantex, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.|Fédération Hospitalo-Universitaire OMICARE, Centre de Recherche d'Immunologie et d'Hématologie, Strasbourg, France.
authors.forename: S
authors.initials: S
authors.lastname: Bahram
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000254:growth & development / Q000472:pathogenicity / Q000821:virology*; D001424:Bacterial Infections / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D015373:Bacterial Typing Techniques / Q000379:methods; D001428:Bacterial Vaccines / Q000096:biosynthesis; D001435:Bacteriophages / Q000502:physiology*; D061505:Cell Surface Display Techniques; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D000071059:Phage Therapy / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents; D001428:Bacterial Vaccines; D004337:Drug Carriers
keywords: antibiotics; bacteriophage; drug delivery; gene therapy; phage display; phage therapy; recombinant antibodies