title: Electrochemically oxidized multiwalled carbon nanotube/glassy carbon electrode as a probe for simultaneous determination of dopamine and doxorubicin in biological samples.
abstract: A facile and effective approach of fabricating oxidized multiwalled carbon nanotube/glassy carbon electrode (OMWCNT/GCE) is herein reported. The OMWCNT/GCE was prepared by electrochemical oxidation method in basic media (0.5 mol L(-1) NaOH solution) and used as a sensor for simultaneous determination of dopamine (DA) and doxorubicin (DOX). Scanning electron microscopy, energy dispersive X-ray spectroscopy and cyclic voltammetry were used for characterization and performance study of the OMWCNT/GCE. The modified electrode exhibited good electrocatalytic properties toward the oxidation of DA and DOX. Peaks potential difference of 240 mV between DA and DOX was large enough to determine DA and DOX individually and simultaneously. Square wave voltammetry (SWV) was used for the simultaneous determination of DA and DOX in their binary mixture. Under the optimum conditions, the linear concentration dependences of SW peak current responses were observed for DA and DOX in the concentration ranges of 0.03-55 μmol L(-1) and 0.04-90 μmol L(-1), respectively. The detection limits (S/N = 3) were 8.5 × 10(-3) μmol L(-1), and 9.4 × 10(-3) μmol L(-1) for DA and DOX, respectively. The analytical utility of OMWCNT/GCE was also successfully demonstrated for the simultaneous determination of DA and DOX in human blood serum and urine samples. Graphical Abstract Fabrication of new oxidized multiwalled carbon nanotube/glassy carbon electrode for simultaneous determination of dopamine and doxorubicin.
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 65174, Iran.
authors.forename: Esmaeel
authors.initials: E
authors.lastname: Haghshenas
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 65174, Iran. madrakian@basu.ac.ir.
authors.forename: Tayyebeh
authors.initials: T
authors.lastname: Madrakian
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 65174, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Afkhami
mesh_terms: D002244:Carbon / Q000737:chemistry*; D004298:Dopamine / Q000032:analysis*; D004317:Doxorubicin / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon; D010084:Oxidation-Reduction; D015203:Reproducibility of Results
chemical_list: D037742:Nanotubes, Carbon; D002244:Carbon; D004317:Doxorubicin; D004298:Dopamine
keywords: Dopamine; Doxorubicin; Multiwalled carbon nanotube; Simultaneous determination; Square wave voltammetry