title: Can we find a possible structural explanation for antibody-dependent enhancement of dengue virus infection resulting in hemorrhagic fever?
abstract: Dengue virus infection is one of the most prevalent mosquito-borne illnesses worldwide, affecting as many as 400 million persons annually. Most people experience a self-limited viral illness, but some experience life-threatening disease. Subsequent infection with other dengue virus serotypes increases the risk of development of severe dengue disease with plasma leakage with or without hemorrhage and end organ impairment. Antibody-dependent enhancement of dengue virus infection has been implicated in the development of severe dengue disease, previously referred to as dengue hemorrhagic fever and dengue shock syndrome. We propose a structural explanation for the role of non-neutralizing antibodies in the development of antibody-dependent enhancement of dengue virus infection via complement fixation or binding to Fcγ receptors facilitating entry into target cells.
authors.affiliation: Walter Reed National Military Medical Center, Department of Medicine, Allergy/Immunology/Immunizations Service, 4954 North Palmer Road, Bethesda, MD 20889-5600, USA. Electronic address: cecilia.p.mikita.civ@mail.mil.
authors.forename: Cecilia P
authors.initials: CP
authors.lastname: Mikita
authors.affiliation: 4006 Simms Drive, Kensington, MD 20895-1336, USA.
authors.forename: Eduardo A
authors.initials: EA
authors.lastname: Padlan
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology*; D019067:Antibody-Dependent Enhancement; D003165:Complement System Proteins / Q000276:immunology; D003715:Dengue / Q000150:complications / Q000276:immunology* / Q000821:virology; D003716:Dengue Virus / Q000276:immunology*; D000939:Epitopes / Q000737:chemistry; D006482:Hemorrhagic Fevers, Viral / Q000150:complications / Q000276:immunology* / Q000821:virology; D006801:Humans; D008962:Models, Theoretical; D000072417:Protein Domains; D017452:Receptors, IgG / Q000378:metabolism; D065288:Serogroup; D012769:Shock / Q000150:complications / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D000939:Epitopes; D017452:Receptors, IgG; D003165:Complement System Proteins