title: Resveratrol is equipotent to perindopril in attenuating post-infarct cardiac remodeling and contractile dysfunction in rats.
abstract: BACKGROUND
  Angiotensin-converting enzyme (ACE) inhibitors improve prognosis in patients with post-myocardial infarction (MI) related cardiac dysfunction. Resveratrol is a polyphenol that has been reported to be beneficial in hypertension, ischemic heart disease, and cardiotoxicity in preclinical studies. Accordingly, we investigated the comparative and combinatorial efficacy of resveratrol and perindopril (ACE inhibitor) treatment on MI-related cardiac remodeling and contractile dysfunction.
  
  
  METHODS
  Left anterior descending artery-ligated and sham-operated male Sprague-Dawley rats were gavaged with vehicle, resveratrol, perindopril, and combination of resveratrol+perindopril (2.5 mg/kg bodyweight/day) for 8 weeks (starting immediately after acute MI). Echocardiography was performed to assess cardiac structure and function at baseline and 8 weeks.
  
  
  RESULTS
  At 8 weeks, vehicle-MI rats had a significantly lower left ventricular ejection fraction (LVEF) and increased LV dilatation compared to vehicle-sham rats. MI rats treated with resveratrol, perindopril and a combination of both had significantly improved LVEF and reduced LV dilatation. Vehicle-treated MI rats also had increased level of lipid peroxidation product- malondialdehyde (MDA), proinflammatory protein- tumor necrosis factor-alpha (TNF-α) and cardiac fibrosis marker- collagen and decreased enzymatic activity of superoxide dismutase and catalase compared to vehicle-sham rats. Resveratrol, perindopril and combination of both significantly prevented the /ed to determine systolic functional parameter increase in MDA, TNF-α and collagen and improved the activity of superoxide dismutase and catalase in MI rats compared to vehicle-MI rats.
  
  
  CONCLUSIONS
  Treatment with resveratrol or perindopril was equivalent in significantly improving remodeling and attenuation of contractile dysfunction in MI rats. Combination treatment also attenuated the cardiac abnormalities. The improvement in cardiac abnormalities may partly be through reducing oxidative stress by preventing the decrease in the activity of superoxide dismutase and catalase, and decreasing cardiac inflammation and fibrosis.
authors.affiliation: Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg; Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg.
authors.forename: Pema
authors.initials: P
authors.lastname: Raj
authors.affiliation: Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg; Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg.
authors.forename: Basma Milad
authors.initials: BM
authors.lastname: Aloud
authors.affiliation: Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg; Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg.
authors.forename: Xavier Lieben
authors.initials: XL
authors.lastname: Louis
authors.affiliation: Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg; Agriculture and Agri-Food Canada.
authors.forename: Liping
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg; Section of Cardiology, Department of Medicine, University of Manitoba, Winnipeg. Electronic address: szieroth@sbgh.mb.ca.
authors.forename: Shelley
authors.initials: S
authors.lastname: Zieroth
authors.affiliation: Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg; Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg; Agriculture and Agri-Food Canada. Electronic address: tnetticadan@sbrc.ca.
authors.forename: Thomas
authors.initials: T
authors.lastname: Netticadan
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D020913:Perindopril / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D013267:Stilbenes; D000077185:Resveratrol; D020913:Perindopril
keywords: Acute myocardial infarction; Cardiac dysfunction; Cardiac remodeling; Perindopril; Resveratrol