title: IMMUNOHISTOCHEMICAL ANALYSIS OF MAMMARY EPITHELIAL CELLS AT TUMORAL GROWTH IN REPUBLIC OF SAKHA (YAKUTIA).
abstract: The analysis of results histological examination of surgical material of breast cancer from 294 women with subsequent immunohistochemical determination of estrogen (ER)--and progesterone (PgR)--receptors, proliferative activity (Ki-67), expression of the mutant suppressor gene (p53) and gene-inhibitor apoptosis (bcl-2) was carried out. The obtained data testify that IHC-research of the tumor progression markers is a defining part in the forecast of course, optimization of therapeutic approaches with an individualization of chemo-, hormonal and beam therapy of mammary cancer, the decision of a question of medicamentous and/or surgical shutdown of the ovaries, based on the research results of the biological activity markers of the tumor.
authors.forename: M P
authors.initials: MP
authors.lastname: Kirillina
authors.forename: K S
authors.initials: KS
authors.lastname: Loskutova
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.forename: L M
authors.initials: LM
authors.lastname: Nepomnyaschih
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D001110:Arctic Regions; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000648:ultrastructure; D004847:Epithelial Cells / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008875:Middle Aged; D044382:Population Groups; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D012426:Russia
chemical_list: D051017:Apoptosis Regulatory Proteins; D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone