title: Hematopoietic stem cells: multiparameter regulation.
abstract: Hematopoietic stem cells (HSCs) are capable to self-renew with multi-potency which generated much excitement in clinical therapy. However, the main obstacle of HSCs in clinical application was insufficient number of HSCs which were derived from either bone marrow, peripheral blood or umbilical cord blood. This review briefly discusses the indispensable utility of growth factors and cytokines, stromal cells, extracellular matrix, bionic scaffold and microenvironment aiming to control the hematopoiesis in all directions and provide a better and comprehensive understanding for in vitro expansion of hematopoietic stem cells.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, 116024, China. kedongsong@dlut.edu.cn.
authors.forename: Kedong
authors.initials: K
authors.lastname: Song
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, 116024, China.
authors.forename: Liying
authors.initials: L
authors.lastname: Li
authors.affiliation: Burns Research Group, ANZAC Research Institute, University of Sydney, Concord, NSW, 2139, Australia.
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, 116024, China.
authors.forename: Tianqing
authors.initials: T
authors.lastname: Liu
mesh_terms: D001773:Blood Cells / Q000166:cytology*; D001854:Bone Marrow Cells / Q000166:cytology*; D002454:Cell Differentiation; D016207:Cytokines; D005109:Extracellular Matrix; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D055153:Stem Cell Niche; D017154:Stromal Cells / Q000166:cytology
chemical_list: D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins
keywords: Ex vivo expansion; Hematopoietic stem cells (HSCs); Multiparameter regulation