title: Nanoparticulate Drug Delivery to Colorectal Cancer: Formulation Strategies and Surface Engineering.
abstract: The evolution of polymer-based nanoparticle as a drug delivery carrier has greatly contributed to the development of advanced nano and micro-medicine in the past few decades. The polymer-based nanoparticles of biodegradable and biocompatible polymers such as poly (lactide-co-glycolide) and chitosan which have been approved by Food & Drug Administration and/or European Medicine Agency can particularly facilitate the maintaining of specific properties for a real transition from laboratory to the clinical oral and parental administration. This review presents an overview of the strategies of preparing polymeric nanoparticles and using them for targeting colorectal cancer. Theranostics and surface engineering aspects of nanoparticle design in colonic cancer delivery are also highlighted.
authors.forename: Thao Truong-Dinh
authors.initials: TT
authors.lastname: Tran
authors.forename: Phuong Ha-Lien
authors.initials: PH
authors.lastname: Tran
authors.forename: Yichao
authors.initials: Y
authors.lastname: Wang
authors.forename: Puwang
authors.initials: P
authors.lastname: Li
authors.affiliation: Institute for Frontier Materials, Deakin University, Waurn Ponds, Victoria, 3217, Australia. lingxue.kong@deakin.edu.au.
authors.forename: Lingxue
authors.initials: L
authors.lastname: Kong
mesh_terms: D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000188:drug therapy; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D011108:Polymers