title: Hepatitis C virus relies on lipoproteins for its life cycle.
abstract: Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.
authors.affiliation: Germana Grassi, Giorgia Di Caprio, Gian Maria Fimia, Giuseppe Ippolito, Marco Tripodi, Tonino Alonzi, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.
authors.forename: Germana
authors.initials: G
authors.lastname: Grassi
authors.affiliation: Germana Grassi, Giorgia Di Caprio, Gian Maria Fimia, Giuseppe Ippolito, Marco Tripodi, Tonino Alonzi, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Di Caprio
authors.affiliation: Germana Grassi, Giorgia Di Caprio, Gian Maria Fimia, Giuseppe Ippolito, Marco Tripodi, Tonino Alonzi, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Fimia
authors.affiliation: Germana Grassi, Giorgia Di Caprio, Gian Maria Fimia, Giuseppe Ippolito, Marco Tripodi, Tonino Alonzi, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ippolito
authors.affiliation: Germana Grassi, Giorgia Di Caprio, Gian Maria Fimia, Giuseppe Ippolito, Marco Tripodi, Tonino Alonzi, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Tripodi
authors.affiliation: Germana Grassi, Giorgia Di Caprio, Gian Maria Fimia, Giuseppe Ippolito, Marco Tripodi, Tonino Alonzi, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.
authors.forename: Tonino
authors.initials: T
authors.lastname: Alonzi
mesh_terms: D000818:Animals; D016174:Hepacivirus / Q000254:growth & development* / Q000378:metabolism*; D006526:Hepatitis C / Q000175:diagnosis / Q000378:metabolism* / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D008018:Life Cycle Stages; D008074:Lipoproteins / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000821:virology; D015398:Signal Transduction; D014771:Virion / Q000378:metabolism; D053586:Virus Internalization; D014779:Virus Replication
chemical_list: D008074:Lipoproteins
keywords: Apolipoproteins; Hepatitis C virus; Lipid metabolism; Lipoproteins; Review