title: Study of Transposable Elements and Their Genomic Impact.
abstract: Transposable elements (TEs) have been considered traditionally as junk DNA, i.e., DNA sequences that despite representing a high proportion of genomes had no evident cellular functions. However, over the last decades, it has become undeniable that not only TE-derived DNA sequences have (and had) a fundamental role during genome evolution, but also TEs have important implications in the origin and evolution of many genomic disorders. This concise review provides a brief overview of the different types of TEs that can be found in genomes, as well as a list of techniques and methods used to study their impact and mobilization. Some of these techniques will be covered in detail in this Method Book.
authors.affiliation: Department of Human DNA Variability, Pfizer/University of Granada and Andalusian Regional Government Center for Genomics and Oncology (GENYO), Avda Ilustracion 114, PTS Granada, 18016, Granada, Spain. martin.munoz@genyo.es.
authors.forename: Martin
authors.initials: M
authors.lastname: Muñoz-Lopez
authors.affiliation: Department of Human DNA Variability, Pfizer/University of Granada and Andalusian Regional Government Center for Genomics and Oncology (GENYO), Avda Ilustracion 114, PTS Granada, 18016, Granada, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Vilar-Astasio
authors.affiliation: Department of Human DNA Variability, Pfizer/University of Granada and Andalusian Regional Government Center for Genomics and Oncology (GENYO), Avda Ilustracion 114, PTS Granada, 18016, Granada, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Tristan-Ramos
authors.affiliation: Department of Human DNA Variability, Pfizer/University of Granada and Andalusian Regional Government Center for Genomics and Oncology (GENYO), Avda Ilustracion 114, PTS Granada, 18016, Granada, Spain.
authors.forename: Cesar
authors.initials: C
authors.lastname: Lopez-Ruiz
authors.affiliation: -Genyo (Center for Genomics and Oncological Research), Pfizer/Universidad de Granada/Junta de Andalucia. PTS Granada, Spain-Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh,, Edinburgh, UK.
authors.forename: Jose L
authors.initials: JL
authors.lastname: Garcia-Pérez
mesh_terms: D004251:DNA Transposable Elements; D005786:Gene Expression Regulation; D015894:Genome, Human; D023281:Genomics / Q000379:methods; D006801:Humans; D020084:Long Interspersed Nucleotide Elements; D018626:Retroelements
chemical_list: D004251:DNA Transposable Elements; D018626:Retroelements
keywords: DNA transposon; LINE-1; Retrotransposition; Retrotransposon; SINE; Transposable element; Transposition