title: A Systems Biology Approach to the Coordination of Defensive and Offensive Molecular Mechanisms in the Innate and Adaptive Host-Pathogen Interaction Networks.
abstract: Infected zebrafish coordinates defensive and offensive molecular mechanisms in response to Candida albicans infections, and invasive C. albicans coordinates corresponding molecular mechanisms to interact with the host. However, knowledge of the ensuing infection-activated signaling networks in both host and pathogen and their interspecific crosstalk during the innate and adaptive phases of the infection processes remains incomplete. In the present study, dynamic network modeling, protein interaction databases, and dual transcriptome data from zebrafish and C. albicans during infection were used to infer infection-activated host-pathogen dynamic interaction networks. The consideration of host-pathogen dynamic interaction systems as innate and adaptive loops and subsequent comparisons of inferred innate and adaptive networks indicated previously unrecognized crosstalk between known pathways and suggested roles of immunological memory in the coordination of host defensive and offensive molecular mechanisms to achieve specific and powerful defense against pathogens. Moreover, pathogens enhance intraspecific crosstalk and abrogate host apoptosis to accommodate enhanced host defense mechanisms during the adaptive phase. Accordingly, links between physiological phenomena and changes in the coordination of defensive and offensive molecular mechanisms highlight the importance of host-pathogen molecular interaction networks, and consequent inferences of the host-pathogen relationship could be translated into biomedical applications.
authors.affiliation: Automatic control, Signal processing, and Systems Biology Lab, National Tsing Hua University, Hsinchu, 30013, Taiwan.
authors.forename: Chia-Chou
authors.initials: CC
authors.lastname: Wu
authors.affiliation: Automatic control, Signal processing, and Systems Biology Lab, National Tsing Hua University, Hsinchu, 30013, Taiwan.
authors.forename: Bor-Sen
authors.initials: BS
authors.lastname: Chen
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000502:physiology*; D015536:Down-Regulation; D054884:Host-Pathogen Interactions / Q000276:immunology*; D007113:Immunity, Innate; D007156:Immunologic Memory; D013045:Species Specificity; D049490:Systems Biology / Q000379:methods*; D015854:Up-Regulation; D015027:Zebrafish / Q000382:microbiology*