title: Extraction and antioxidant activity of flavonoids of Morus nigra.
abstract: Morus nigra has a long history of medicinal use in Chinese medicine, but the study on it is limited, the flavonoids are one of the main biological active substances. In this study, the Morus nigra flavonoids were extracted by ultrasonic and antioxidant activities both in vitro and in vivo were measured. The results showed that hydroxyl radicals clearance rate and superoxide radical anion clearance rate in vitro increased with the concentration of the total flavonoids in the range of 0-1.05 mg/mL and the maximum clearance rate was 80.33% and 87.69%, respectively. After mice were treated with flavonoids, the content of malonaldehyde (MDA) in serum and liver decreased; the activities of superoxide dismutase (SOD) in serum and liver, catalase (CAT) in liver and glutathione peroxidase (GSH-PX) in blood and liver increased; Langhans cells increased in spleen. These results revealed that the Morus nigra flavonoids possessed strong antioxidant activity.
authors.affiliation: Key Lab of Aromatic Plant Resources Exploitation and Utilization in Sichuan Higher Education, Yibin University Yibin, 644000, China.
authors.forename: Rui-Zhang
authors.initials: RZ
authors.lastname: Feng
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Wen-Zhi
authors.initials: WZ
authors.lastname: Tong
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xiong
authors.affiliation: Key Lab of Aromatic Plant Resources Exploitation and Utilization in Sichuan Higher Education, Yibin University Yibin, 644000, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Key Lab of Aromatic Plant Resources Exploitation and Utilization in Sichuan Higher Education, Yibin University Yibin, 644000, China.
authors.forename: Wan-Hai
authors.initials: WH
authors.lastname: Zhou
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Zhong-Qiong
authors.initials: ZQ
authors.lastname: Yin
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Xiao-Ya
authors.initials: XY
authors.lastname: Yin
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Wang
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Ya-Qin
authors.initials: YQ
authors.lastname: Chen
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Lai
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Huang
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Qiao-Li
authors.initials: QL
authors.lastname: Luo
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Ren-Yong
authors.initials: RY
authors.lastname: Jia
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Song
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Yuan-Feng
authors.initials: YF
authors.lastname: Zou
authors.affiliation: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Li
keywords: Morus nigra; antioxidant activity; total flavonoids