title: Comparison of recovery parameters for xenon versus other inhalation anesthetics: systematic review and meta-analysis.
abstract: OBJECTIVE
  To summarize and evaluate the available data describing the recovery parameters of xenon anesthesia.
  
  
  METHODS
  Systematic review and meta-analysis.
  
  
  METHODS
  Anesthesia for elective surgeries.
  
  
  METHODS
  Systematic review of randomized controlled trials (RCTs) from databases including Medline (1964-2013), the Cochrane Central Register of Controlled Trials (CENTRAL, 1990-2012), and Google Scholar (1966-2013).
  
  
  METHODS
  Inhalation of xenon or other anesthetics was administered in elective surgery.
  
  
  METHODS
  Recovery parameters (time to recovery, alertness/sedation scale scores at "eye opening," bispectral index at "reaction on demand," time to extubation, and time to orientation).
  
  
  RESULTS
  Eleven RCTs (N = 661 patients) met the inclusion criteria. Recovery from xenon anesthesia was significantly faster in terms of the time to eye opening (mean difference [MD], -4.18 minutes; 95% confidence interval [CI], -5.03 to -3.32 minutes; P < .00001), the time to reaction on demand (MD, -5.35 minutes; 95% CI, -6.59 to -4.11 minutes; P < .00001), the time to extubation (MD, -4.49 minutes; 95% CI, -5.40 to -3.58 minutes; P < .00001), and the time to orientation (MD, -4.99 minutes; 95% CI, -6.45 to -3.52 minutes; P < .00001).
  
  
  CONCLUSIONS
  This meta-analysis confirmed that recovery from xenon anesthesia is faster than other inhalation anesthesia.
authors.affiliation: Department of General Surgery, Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52 East Meihua Road, Zhuhai, Guangdong 519000, China.
authors.forename: Bingzong
authors.initials: B
authors.lastname: Hou
authors.affiliation: Department of Anaesthesiology, Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52 East Meihua Road, Zhuhai, Guangdong 519000, China.
authors.forename: Fujing
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Anaesthesiology, Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52 East Meihua Road, Zhuhai, Guangdong 519000, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Ou
authors.affiliation: Department of Anaesthesiology, Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52 East Meihua Road, Zhuhai, Guangdong 519000, China. Electronic address: 1404081473@qq.com.
authors.forename: Lukun
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Anaesthesiology, Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52 East Meihua Road, Zhuhai, Guangdong 519000, China. Electronic address: zsp005@163.com.
authors.forename: Shaopeng
authors.initials: S
authors.lastname: Zhou
mesh_terms: D060666:Airway Extubation; D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation / Q000379:methods; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D003243:Consciousness / Q000187:drug effects*; D017558:Elective Surgical Procedures; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors; D014978:Xenon / Q000494:pharmacology*
chemical_list: D018685:Anesthetics, Inhalation; D014978:Xenon
keywords: Anesthesia; Inhalation; Postoperative; Recovery; Xenon