title: The role of cardiac biochemical markers in aortic stenosis.
abstract: Calcified aortic stenosis is one of the most common causes of heart failure in the elderly. Current guidelines recommend aortic valve replacement in patients with severe disease and evidence of decompensation based on either symptoms or impaired systolic ejection fraction. However, symptoms are often subjective whilst impaired ejection fraction is not a sensitive marker of ventricular decompensation. Interest has surrounded the use of cardiac biochemical markers as objective measures of left ventricular decompensation in aortic stenosis. We will first examine mechanisms of release of biochemical markers associated with myocardial wall stress (BNP/NT-proBNP), myocardial fibrosis (markers of collagen metabolism, galectin-3, soluble ST2) and myocyte death/myocardial ischemia (high-sensitivity cardiac troponins, heart-type fatty acid binding protein, myosin-binding protein C); and discuss future directions of these markers.
authors.affiliation: a Department of Cardiovascular Medicine , National Heart Center Singapore , Singapore .|b Duke-NUS Graduate Medical School , Singapore .
authors.forename: Calvin W L
authors.initials: CW
authors.lastname: Chin
authors.affiliation: c Barts and the London School of Medicine & Dentistry, Queen Mary, University of London , London , UK , and.
authors.forename: Andie H
authors.initials: AH
authors.lastname: Djohan
authors.affiliation: d Division of Cardiovascular and Diabetes Medicine , University of Dundee , Dundee , UK.
authors.forename: Chim C
authors.initials: CC
authors.lastname: Lang
mesh_terms: D001024:Aortic Valve Stenosis / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D002114:Calcinosis; D006801:Humans
chemical_list: D015415:Biomarkers
keywords: Aortic stenosis; cardiac biochemical markers; left ventricular hypertrophy; myocardial fibrosis