title: There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases.
abstract: Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis with associated frontotemporal dementia (ALS/FTD) are major neurodegenerative diseases for which there are no cures. All are characterised by damage to several seemingly disparate cellular processes. The broad nature of this damage makes understanding pathogenic mechanisms and devising new treatments difficult. Can the different damaged functions be linked together in a common disease pathway and which damaged function should be targeted for therapy? Many functions damaged in neurodegenerative diseases are regulated by communications that mitochondria make with a specialised region of the endoplasmic reticulum (ER; mitochondria-associated ER membranes or 'MAM'). Moreover, several recent studies have shown that disturbances to ER-mitochondria contacts occur in neurodegenerative diseases. Here, we review these findings.
authors.affiliation: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Paillusson
authors.affiliation: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.
authors.forename: Radu
authors.initials: R
authors.lastname: Stoica
authors.affiliation: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.
authors.forename: Patricia
authors.initials: P
authors.lastname: Gomez-Suaga
authors.affiliation: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.
authors.forename: Dawn H W
authors.initials: DHW
authors.lastname: Lau
authors.affiliation: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Mueller
authors.affiliation: Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, UK. Electronic address: tanya.miller1@nhs.net.
authors.forename: Tanya
authors.initials: T
authors.lastname: Miller
authors.affiliation: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK. Electronic address: chris.miller@kcl.ac.uk.
authors.forename: Christopher C J
authors.initials: CCJ
authors.lastname: Miller
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000648:ultrastructure; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy
keywords: Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis/fronto-temporal dementia; endoplasmic reticulum; mitochondria; mitochondria associated ER membranes