title: Herbal Medicine in Mexico: A Cause of Hepatotoxicity. A Critical Review.
abstract: In Mexico, herbal products are commonly used as therapeutic tools. The analysis of several publications reveals that there are dozens of different herbs and herbal products used for different reasons, some of which have been implicated in causing toxic liver disease. However, methodological aspects limit the attribution of causality, and the precise incidence and clinical manifestations of herb-induced liver injury have not been well characterized. This review outlines the history of traditional herbal medicine in Mexico, critically summarizes the mechanisms and adverse effects of commonly used herbal plants, and examines the regulatory issues regarding the legal use of these products.
authors.affiliation: Liver Research Unit, Medica Sur Clinic &amp; Foundation, 14050 Mexico City, Mexico. bisba100@hotmail.com.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Valdivia-Correa
authors.affiliation: Liver Research Unit, Medica Sur Clinic &amp; Foundation, 14050 Mexico City, Mexico. cristinacgg@hotmail.com.
authors.forename: Cristina
authors.initials: C
authors.lastname: Gómez-Gutiérrez
authors.affiliation: Liver Research Unit, Medica Sur Clinic &amp; Foundation, 14050 Mexico City, Mexico. muribe@medicasur.org.mx.
authors.forename: Misael
authors.initials: M
authors.lastname: Uribe
authors.affiliation: Liver Research Unit, Medica Sur Clinic &amp; Foundation, 14050 Mexico City, Mexico. nmendez@medicasur.org.mx.
authors.forename: Nahum
authors.initials: N
authors.lastname: Méndez-Sánchez
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D064420:Drug-Related Side Effects and Adverse Reactions; D029001:Herbal Medicine / Q000331:legislation & jurisprudence / Q000379:methods; D006801:Humans; D007880:Legislation, Drug; D008800:Mexico / Q000453:epidemiology; D028321:Plant Preparations / Q000009:adverse effects / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D028321:Plant Preparations
keywords: adverse events; drug-induced liver injury (DILI); hepatotoxicity; herb-induced liver injury (HILI); herbal drug supplements (HDS); herbal medicine; regulation