title: Near Full-Length Genomic Characterization of a Novel HIV Type 1 CRF01_AE/CRF07_BC Recombinant Form Transmitted Between a Heterosexual Couple in Guangxi, China.
abstract: In this research, we reported a new second generation recombinant form (GXDY460B) between circulating recombinant form (CRF)01_AE and CRF07_BC in a seroconversion couple who obtained the virus from her husband by heterosexual behavior. The analysis result of the near full-length genomic characterization showed that the genome comprises at least 12 interlaced segments, including six CRF07_BC and six CRF01_AE segments, with CRF07_BC as the main framework. Cocirculation of multiple virus subtypes and multiple infection routes have existed for a long time in Guangxi, but the recombinant strain was rarely reported among heterosexual transmission population because of its lower crowd confounding degree than men who have sex with men and injecting drug user population. It is the first time that the unique recombinant form (URF) between CRF01_AE and CRF07_BC was identified among heterosexual transmission in Guangxi. The emergence of the novel recombinant helps to understand the pattern of the URF virus.
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .|2 School of Public Health, Peking Union Medical College , Beijing, People's Republic of China .
authors.forename: Zhe
authors.initials: Z
authors.lastname: Dong
authors.affiliation: 3 Guangxi Center for Disease Prevention and Control , Nanning, People's Republic of China .
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Shen
authors.affiliation: 3 Guangxi Center for Disease Prevention and Control , Nanning, People's Republic of China .
authors.forename: Runsong
authors.initials: R
authors.lastname: Xiong
authors.affiliation: 3 Guangxi Center for Disease Prevention and Control , Nanning, People's Republic of China .
authors.forename: Fuxiong
authors.initials: F
authors.lastname: Liang
authors.affiliation: 3 Guangxi Center for Disease Prevention and Control , Nanning, People's Republic of China .
authors.forename: Shujia
authors.initials: S
authors.lastname: Liang
authors.affiliation: 3 Guangxi Center for Disease Prevention and Control , Nanning, People's Republic of China .
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
authors.affiliation: 3 Guangxi Center for Disease Prevention and Control , Nanning, People's Republic of China .
authors.forename: Guangjie
authors.initials: G
authors.lastname: Tan
authors.affiliation: 3 Guangxi Center for Disease Prevention and Control , Nanning, People's Republic of China .
authors.forename: He
authors.initials: H
authors.lastname: Jiang
authors.affiliation: 3 Guangxi Center for Disease Prevention and Control , Nanning, People's Republic of China .
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Yang
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Fan
authors.initials: F
authors.lastname: Li
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Lingjie
authors.initials: L
authors.lastname: Liao
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .|4 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Hangzhou, People's Republic of China .
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: 3 Guangxi Center for Disease Prevention and Control , Nanning, People's Republic of China .
authors.forename: Qiuying
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D002681:China; D005191:Family Characteristics; D005260:Female; D016679:Genome, Viral; D005838:Genotype; D015658:HIV Infections / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D020010:Heterosexuality; D006801:Humans; D008297:Male; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA