title: The Aldosterone Renin Ratio (ARR) APP as Tool to Enhance the Detection Rate of Primary Aldosteronism.
abstract: Primary aldosteronism is one of the most common forms of secondary hypertension, but it is often under diagnosed, which leads to the development of cardiovascular damage, and excess costs for long-term drug treatment and management of complications. The aldosterone to renin ratio (ARR) is a key step for early detection of primary aldosteronism, but unfortunately is not easily estimated. This is because plasma aldosterone and renin are measured with different assays, which provide results in different units of measure, with ensuing difficulty of obtaining the calculation of the ARR in the proper units and impossibility of interpreting results with reference to established cut off values. Therefore, doctors are often unable to draw unambiguous conclusions to be used for the clinical decision-making. To the aim of making the diagnostic work-up easier, we have developed an Application that provide a swift calculation of the ARR regardless of the units of measure used for plasma aldosterone and renin values. If the concomitant serum potassium level is available the App also provides the patient's probability of having an aldosterone-producing adenoma based on a validated logistic discriminant analysis.
authors.affiliation: Clinica dell'Ipertensione Arteriosa, Department of Medicine-DIMED, University Hospital, Via Giustiniani, 2, 35126, Padova, Italy. gianpaolo.rossi@unipd.it.
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Rossi
authors.affiliation: Clinica dell'Ipertensione Arteriosa, Department of Medicine-DIMED, University Hospital, Via Giustiniani, 2, 35126, Padova, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Bisogni
mesh_terms: D000450:Aldosterone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003936:Diagnosis, Computer-Assisted; D016002:Discriminant Analysis; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006973:Hypertension / Q000209:etiology; D016015:Logistic Models; D063731:Mobile Applications; D011188:Potassium / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D000450:Aldosterone; D012083:Renin; D011188:Potassium
keywords: Aldosterone; Arterial hypertension; Primary aldosteronism; Ratio; Renin