title: Prognostic significance of INF-induced transmembrane protein 1 in colorectal cancer.
abstract: Interferon-induced transmembrane protein 1 (IFITM1) has recently been implicated in tumorigenesis. However, the prognostic value of IFITM1 in colorectal cancer remains unknown. The present study aimed to examine the expression and prognostic significance of IFITM1 in human colorectal cancer. IFITM1 expression was analyzed in 144 archived, paraffin-embedded colorectal cancer tissues and corresponding normal colorectal mucosa by immunohistochemistry. The correlation of IFITM1 with clinic-pathological features and overall survival of colorectal cancer patients was evaluated. IFITM1 was overexpressed in colonic cancer tissues but not in rectal cancer tissues, compared to control normal tissues. The expression of IFITM1 was significantly higher in patients with poor differentiation (P=0.031). The patients with higher IFITM1 expression had worse overall survival outcomes than those with lower IFITM1 expression in rectal cancer (P=0.037). Univariate Cox regression suggested that older age and poorly differentiation status predict shorter overall survival in colorectal cancer (P<0.05). However, IFITM1 expression was not a significant prognostic factor for survival by univariate or multivariate analyses. In conclusion, high expression of IFITM1 is associated with poor prognosis of rectal cancer. IFITM1 may serve as an independent prognostic biomarker for colorectal cancer.
authors.affiliation: Department of Oncology, Huai'an First People's Hospital, Nanjing Medical University Huai'an, Jiangsu, China.
authors.forename: Jingdong
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Oncology, Huai'an First People's Hospital, Nanjing Medical University Huai'an, Jiangsu, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Oncology, Huai'an First People's Hospital, Nanjing Medical University Huai'an, Jiangsu, China.
authors.forename: Wanting
authors.initials: W
authors.lastname: Feng
authors.affiliation: Department of Oncology, Jinling Hospital, Nanjing University Nanjing, Jiangsu, China.
authors.forename: Longbang
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, Huai'an First People's Hospital, Nanjing Medical University Huai'an, Jiangsu, China.
authors.forename: Kangqun
authors.initials: K
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000943:Antigens, Differentiation / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002454:Cell Differentiation; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D000943:Antigens, Differentiation; D014408:Biomarkers, Tumor; C062010:leu-13 antigen
keywords: IFITM1; colorectal cancer; immunohistochemistry; prognosis