title: Clinical relevance of antigen spreading pattern induced by CHP-MAGE-A4 cancer vaccination.
abstract: To investigate the antigen spreading pattern in the CHP-MAGE-A4-vaccinated patients and analyze the clinical relevance of antigen spreading pattern as a surrogate marker of patient survival.
  
  
  
  12 patients who had been injected with 300 μg of CHP-MAGE-A4 and 0.5 Klinische Einheit of OK-432 in more than five vaccinations were analyzed.
  
  
  
  Increases in the anti-MAGE-A4-specific antibody response were observed in eight patients (66.7%), compared with six patients (50%) for anti-NY-ESO-1 and five patients (41.7%) for anti-MAGE-A3 after five vaccinations. We identified frequent antigen spreading following MAGE-A4 vaccinations without associations with the clinical response or patient prognosis.
  
  
  
  Antigen spreading pattern might reflect tumor shrinkage as a response to treatment and treatment history (clinical trial registration number: UMIN000001999).
authors.affiliation: Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Miyauchi
authors.affiliation: Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsuchikawa
authors.affiliation: Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Wada
authors.affiliation: Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Abiko
authors.affiliation: Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kyogoku
authors.affiliation: Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shichinohe
authors.affiliation: Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyahara
authors.affiliation: Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kageyama
authors.affiliation: Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ikeda
authors.affiliation: Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiku
authors.affiliation: Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirano
mesh_terms: D000368:Aged; D000906:Antibodies / Q000097:blood; D000951:Antigens, Neoplasm / Q000276:immunology*; D054316:Biomarkers, Pharmacological / Q000378:metabolism; D019496:Cancer Vaccines / Q000276:immunology*; D003110:Colonic Neoplasms / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D000939:Epitopes; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000276:immunology*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000276:immunology*; D016019:Survival Analysis; D047368:Tumor Burden
chemical_list: D000906:Antibodies; D000951:Antigens, Neoplasm; D054316:Biomarkers, Pharmacological; C104948:CTAG1B protein, human; D019496:Cancer Vaccines; D000939:Epitopes; C072013:MAGEA3 protein, human; C095204:MAGEA4 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins
keywords: IgG subtypes; MAGE-A4; antigen spreading; cancer vaccine; immunomonitoring