title: Serotonin transporter gene polymorphism in eating disorders: Data from a new biobank and META-analysis of previous studies.
abstract: Objectives Growing interest focuses on the association between 5-HTTLPR polymorphism and eating disorders (ED), but published findings have been conflicting. Methods The Italian BIO.VE.D.A. biobank provided 976 samples (735 ED patients and 241 controls) for genotyping. We conducted a literature search of studies published up to 1 April 2015, including studies reporting on 5HTTLPR genotype and allele frequencies in obesity and/or ED. We ran a meta-analysis, including data from BIO.VE.D.A. - comparing low and high-functioning genotype and allele frequencies in ED vs.
  
  
  METHODS
  Results Data from 21 studies, plus BIO.VE.D.A., were extracted providing information from 3,736 patients and 2,707 controls. Neither low- nor high-functioning genotype frequencies in ED patients, with both bi- and tri-allelic models, differed from controls. Furthermore, neither low- nor high-functioning allele frequencies in ED or in BN, in both bi- and triallelic models, differed from control groups. After sensitivity analysis, results were the same in AN vs.
  
  
  METHODS
  Results remained unaltered when investigating recessive and dominant models. Conclusions 5HTTLPR does not seem to be associated with ED in general, or with AN or BN in particular. Future studies in ED should explore the role of ethnicity and psychiatric comorbidity as a possible source of bias.
authors.affiliation: a BIO.VE.D.A. Group (BIObanca VEneta per I Disturbi Dell'alimentazione: Biobank of the Veneto Region Eating Disorders Units) , Veneto Region , Italy ;|g Department of Neuroscience , University of Padova , Italy ;
authors.forename: M
authors.initials: M
authors.lastname: Solmi
authors.affiliation: a BIO.VE.D.A. Group (BIObanca VEneta per I Disturbi Dell'alimentazione: Biobank of the Veneto Region Eating Disorders Units) , Veneto Region , Italy ;|g Department of Neuroscience , University of Padova , Italy ;
authors.forename: D
authors.initials: D
authors.lastname: Gallicchio
authors.affiliation: a BIO.VE.D.A. Group (BIObanca VEneta per I Disturbi Dell'alimentazione: Biobank of the Veneto Region Eating Disorders Units) , Veneto Region , Italy ;|g Department of Neuroscience , University of Padova , Italy ;
authors.forename: E
authors.initials: E
authors.lastname: Collantoni
authors.affiliation: c The Zucker Hillside Hospital, Psychiatry Research, NorthShore - Long Island Jewish Health System , Glen Oaks , New York , USA ;|d Hofstra North Shore LIJ School of Medicine , Hempstead , New York , USA ;|e The Feinstein Institute for Medical Research , Manhasset , New York , USA ;|f Albert Einstein College of Medicine , Bronx , New York , USA ;
authors.forename: C U
authors.initials: CU
authors.lastname: Correll
authors.affiliation: h Clinical Genetics Unit, Department of Woman and Child Health , University of Padova ;
authors.forename: M
authors.initials: M
authors.lastname: Clementi
authors.affiliation: h Clinical Genetics Unit, Department of Woman and Child Health , University of Padova ;
authors.forename: C
authors.initials: C
authors.lastname: Pinato
authors.affiliation: h Clinical Genetics Unit, Department of Woman and Child Health , University of Padova ;
authors.forename: M
authors.initials: M
authors.lastname: Forzan
authors.affiliation: h Clinical Genetics Unit, Department of Woman and Child Health , University of Padova ;
authors.forename: M
authors.initials: M
authors.lastname: Cassina
authors.affiliation: a BIO.VE.D.A. Group (BIObanca VEneta per I Disturbi Dell'alimentazione: Biobank of the Veneto Region Eating Disorders Units) , Veneto Region , Italy ;
authors.forename: F
authors.initials: F
authors.lastname: Fontana
authors.affiliation: a BIO.VE.D.A. Group (BIObanca VEneta per I Disturbi Dell'alimentazione: Biobank of the Veneto Region Eating Disorders Units) , Veneto Region , Italy ;|g Department of Neuroscience , University of Padova , Italy ;
authors.forename: V
authors.initials: V
authors.lastname: Giannunzio
authors.affiliation: a BIO.VE.D.A. Group (BIObanca VEneta per I Disturbi Dell'alimentazione: Biobank of the Veneto Region Eating Disorders Units) , Veneto Region , Italy ;
authors.forename: I
authors.initials: I
authors.lastname: Piva
authors.affiliation: a BIO.VE.D.A. Group (BIObanca VEneta per I Disturbi Dell'alimentazione: Biobank of the Veneto Region Eating Disorders Units) , Veneto Region , Italy ;
authors.forename: R
authors.initials: R
authors.lastname: Siani
authors.affiliation: a BIO.VE.D.A. Group (BIObanca VEneta per I Disturbi Dell'alimentazione: Biobank of the Veneto Region Eating Disorders Units) , Veneto Region , Italy ;
authors.forename: P
authors.initials: P
authors.lastname: Salvo
authors.affiliation: a BIO.VE.D.A. Group (BIObanca VEneta per I Disturbi Dell'alimentazione: Biobank of the Veneto Region Eating Disorders Units) , Veneto Region , Italy ;|g Department of Neuroscience , University of Padova , Italy ;|i Centro Neuroscience Cognitive (CNC), University of Padova , Italy.
authors.forename: P
authors.initials: P
authors.lastname: Santonastaso
authors.affiliation: a BIO.VE.D.A. Group (BIObanca VEneta per I Disturbi Dell'alimentazione: Biobank of the Veneto Region Eating Disorders Units) , Veneto Region , Italy ;|g Department of Neuroscience , University of Padova , Italy ;|i Centro Neuroscience Cognitive (CNC), University of Padova , Italy.
authors.forename: E
authors.initials: E
authors.lastname: Tenconi
authors.affiliation: b Department of Medicine- DIMED , Geriatrics Section, University of Padova , Italy ;
authors.forename: N
authors.initials: N
authors.lastname: Veronese
authors.affiliation: a BIO.VE.D.A. Group (BIObanca VEneta per I Disturbi Dell'alimentazione: Biobank of the Veneto Region Eating Disorders Units) , Veneto Region , Italy ;|g Department of Neuroscience , University of Padova , Italy ;|i Centro Neuroscience Cognitive (CNC), University of Padova , Italy.
authors.forename: A
authors.initials: A
authors.lastname: Favaro
mesh_terms: D000856:Anorexia Nervosa / Q000235:genetics*; D018070:Biological Specimen Banks; D052018:Bulimia Nervosa / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D009765:Obesity; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
keywords: 5-HTTLPR; Eating disorders; anorexia nervosa; binge eating; bulimia nervosa