title: Universal Molecular Scaffold for Facile Construction of Multivalent and Multimodal Imaging Probes.
abstract: Multivalent and multimodal imaging probes are rapidly emerging as powerful chemical tools for visualizing various biochemical processes. Herein, we described a bifunctional chelator (BFC)-based scaffold that can be used to construct such promising probes concisely. Compared to other reported similar scaffolds, this new BFC scaffold demonstrated two major advantages: (1) significantly simplified synthesis due to the use of this new BFC that can serve as chelator and linker simultaneously; (2) highly efficient synthesis rendered by using either click chemistry and/or total solid-phase synthesis. In addition, the versatile utility of this molecular scaffold has been demonstrated by constructing several multivalent/multimodal imaging probes labeled with various radioisotopes, and the resulting radiotracers demonstrated substantially improved in vivo performance compared to the two individual monomeric counterparts.
authors.affiliation: School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China.|Department of Radiology, University of Pittsburgh , 100 Technology Drive, Suite 452D, Pittsburgh, Pennsylvania 15219, United States.
authors.forename: Yongkang
authors.initials: Y
authors.lastname: Gai
authors.affiliation: School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China.
authors.forename: Guangya
authors.initials: G
authors.lastname: Xiang
authors.affiliation: School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.affiliation: College of Pharmacy, Third Military Medical University , Chongqing 400038, China.
authors.forename: Wenqi
authors.initials: W
authors.lastname: Hui
authors.affiliation: College of Pharmacy, Third Military Medical University , Chongqing 400038, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Ouyang
authors.affiliation: Department of Radiology, University of Pittsburgh , 100 Technology Drive, Suite 452D, Pittsburgh, Pennsylvania 15219, United States.
authors.forename: Lingyi
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Radiology, University of Pittsburgh , 100 Technology Drive, Suite 452D, Pittsburgh, Pennsylvania 15219, United States.
authors.forename: Jiule
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of Radiology, University of Pittsburgh , 100 Technology Drive, Suite 452D, Pittsburgh, Pennsylvania 15219, United States.
authors.forename: Jing
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Department of Radiology, University of Pittsburgh , 100 Technology Drive, Suite 452D, Pittsburgh, Pennsylvania 15219, United States.
authors.forename: Dexing
authors.initials: D
authors.lastname: Zeng
mesh_terms: D000818:Animals; D005453:Fluorescence; D051379:Mice; D008958:Models, Molecular; D015335:Molecular Probes; D064847:Multimodal Imaging / Q000295:instrumentation*
chemical_list: D015335:Molecular Probes