title: Clinicopathological associations of acquired erythroblastopenia.
abstract: BACKGROUND
  Acquired erythroblastopenia (AE) is a rare clinical situation. It is characterized by the reduction of erythroid precursors in the bone marrow together with the low reticulocyte counts in the peripheral blood.
  
  
  BACKGROUND
  Main secondary causes of AE are drugs, Parvovirus B19 and other infectious reasons, lymphoid and myeloid neoplasia, autoimmune diseases, thymoma and pregnancy. The aim of this study is to assess the frequencies and clinical associations of AE via analyzing 12340 bone marrow samples in a retrospective manner.
  
  
  METHODS
  Bone marrow aspirations which were obtained from patients who applied to Hacettepe University Hematology Clinic between 2002 and 2013, were analyzed retrospectively.
  
  
  RESULTS
  Thirty four erythroblastopenia cases were found. Patients ranged in age from 16 to 80 years with a median of 38 years. Fifteen patients were men (44%) and nineteen were women (56%). In these patients, detected causes of erythroblastopenia were MDS, idiopathic pure red cell aplasia (PRCA), parvovirus infection, post chemotherapy aplasia, plasma proliferative diseases, copper deficiency due to secondary amyloidosis, fever of unknown origin, hemophagocytic syndrome, enteric fever and legionella pneumonia. We found that between those reasons the most common causes of erythroblastopenia are MDS (17.7%) and idiopathic PRCA (17.7%).
  
  
  CONCLUSIONS
  As a result, erythroblastopenia in the bone marrow may be an early sign of MDS. In those AE cases possibility of being MDS must be kept in mind as it can be mistaken for PRCA.
  
  
  CONCLUSIONS
  To conclude, in adults MDS without excess blast is one of the most common causes of erythroblastopenia in clinical practice and in case of erythroblastopenia the presence of MDS should be investigated.
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Gursel
authors.initials: G
authors.lastname: Gunes
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Umit Yavuz
authors.initials: UY
authors.lastname: Malkan
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Hatime Arzu
authors.initials: HA
authors.lastname: Yasar
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Eylem
authors.initials: E
authors.lastname: Eliacik
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Ibrahim Celalettin
authors.initials: IC
authors.lastname: Haznedaroglu
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Haluk
authors.initials: H
authors.lastname: Demiroglu
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Nilgun
authors.initials: N
authors.lastname: Sayinalp
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Aksu
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Sezgin
authors.initials: S
authors.lastname: Etgul
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Aslan
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Goker
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Osman Ilhami
authors.initials: OI
authors.lastname: Ozcebe
authors.affiliation: Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
authors.forename: Yahya
authors.initials: Y
authors.lastname: Buyukasik
keywords: Erythroblastopenia; myelodisplastic syndrome; pure red cell aplasia