title: Level of Oxidative Stress Markers in Peri-Implant Crevicular Fluid and Their Correlation with Clinical Parameters.
abstract: OBJECTIVE
  Increased levels of oxidative stress markers in periodontitis have been reported by recent studies. Malondialdehyde (MDA) and superoxide dismutase (SOD) are both increased during oxidative stress. The aim of this study was to detect and measure the level of oxidative stress markers in peri-implant crevicular fluid (PICF). Their correlation with peri-implant clinical parameters was investigated as well.
  
  
  METHODS
  PICF samples of 50 dental implants were collected in 31 patients. Peri-implant clinical parameters including probing pocket depth (PPD), gingival index (GI) and bleeding on probing (BOP) were recorded. Levels of oxidative stress markers including MDA, SOD and total antioxidant capacity (TAC) in PICF were determined.
  
  
  RESULTS
  Twenty four implants showed signs of inflammation and 26 implants had healthy peri-implant tissues. MDA and TAC were detected in all samples, but SOD was not detected around 31 implants. The differences between the two groups with respect to the levels of MDA, TAC and SOD in PICF were not statistically significant (P> 0.05). In addition, significant correlations were observed between PPD and TAC and MDA level (P<0.05).
  
  
  CONCLUSIONS
  Significant correlations exist between PPD and level of MDA and TAC. Moreover, level of oxidative stress markers (MDA, SOD and TAC) in PICF does not significantly change in peri-implantitis compared to healthy implants. Measuring these markers in PICF does not seem to be helpful for discrimination of peri-implant health and disease status.
authors.affiliation: Assistant Professor, Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahvash
authors.initials: M
authors.lastname: Mousavi Jazi
authors.affiliation: Professor, Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Sadeghi Pour Rodsari
authors.affiliation: Assistant Professor, Department of Periodontics, School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Faezeh
authors.initials: F
authors.lastname: Mirmiran
keywords: Antioxidants; Dental Implants; Oxidative Stress