title: [Diagnostic value of STAT6 immunohistochemistry in solitary fibrous tumor/meningeal hemangiopericytoma].
abstract: OBJECTIVE
  To investigate the diagnostic role of STAT6 immunohistochemistry in solitary fibrous tumors (SFT)/meningeal hemangiopericytomas (HPC).
  
  
  METHODS
  Evaluated the expression of STAT6, vimentin, CD34, EMA, PR, S-100, CD56, GFAP and Ki-67 in a cohort of 37 SFT/meningeal HPC, 30 meningiomas and 30 schwannomas by immunohistochemistry staining.
  
  
  RESULTS
  All SFT/meningeal HPC demonstrated nuclear positivity for STAT6, and the proportion of positive tumor cells ranged from 60% to 95%, with no significant difference cases.Vimentin was strongly positive in all cases. CD34, EMA and PR positivity was found in 32 cases, 1 case and 4 cases, respectively.S-100 protein, CD56 and GFAP were negative; Ki-67 labeling index was 1%-8%. However, the meningiomas and schwannomas were negative for STAT6.
  
  
  CONCLUSIONS
  STAT6 is a relatively specific biomarker for SFT/meningeal HPC, and may be used in the diagnosis and differential diagnosis of SFT/meningeal HPC, especially for the atypical cases, and allows the precise pathologic diagnosis of SFT/meningeal HPC.
authors.affiliation: Department of Pathology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Xialing
authors.initials: X
authors.lastname: Zhang
authors.forename: Haixia
authors.initials: H
authors.lastname: Cheng
authors.forename: Yun
authors.initials: Y
authors.lastname: Bao
authors.forename: Feng
authors.initials: F
authors.lastname: Tang
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D003937:Diagnosis, Differential; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006393:Hemangiopericytoma / Q000737:chemistry / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D008579:Meningioma / Q000737:chemistry / Q000175:diagnosis*; D009442:Neurilemmoma / Q000737:chemistry / Q000175:diagnosis*; D009418:S100 Proteins / Q000032:analysis; D050800:STAT6 Transcription Factor / Q000032:analysis*; D054364:Solitary Fibrous Tumors / Q000737:chemistry / Q000175:diagnosis*; D014746:Vimentin / Q000032:analysis
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34; D000945:Antigens, Differentiation, T-Lymphocyte; D014408:Biomarkers, Tumor; C062279:CD6 antigen; D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D009418:S100 Proteins; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human; D014746:Vimentin