title: FibroScan, aspartate aminotransferase and alanine aminotransferase ratio (AAR), aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the 4 factor (FIB-4), and their combinations in the assessment of liver fibrosis in patients with hepatitis B.
abstract: OBJECTIVE
  The aim of this study was to assess the effects of FibroScan, aspartate aminotransferase and alanine aminotransferase ratio (AAR), aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the 4 factor (FIB-4) and their combinations on liver fibrosis in patients with hepatitis B.
  
  
  METHODS
  406 hospitalized patients with chronic hepatitis B (CHB) and cirrhosis in our hospital were analyzed retrospectively and collected patients clinical indicators, including liver stiffness (LS), AAR, APRI and FIB-4, and then compared the differences of these indicators between CHB group and hepatitis B with cirrhosis group. Receiver operating curve (ROC) was used to evaluate the differentiating capacity of these indicators on CHB and liver cirrhosis.
  
  
  RESULTS
  Four indicators related to liver cirrhosis had a statistical significance between two groups (P < 0.01); the under ROC curve areas of LS, AAR, APRI and FIB-4 for differential diagnosis of CHB and liver cirrhosis were 0.866, 0.772, 0.632 and 0.885, respectively. The under ROC curve areas of LS, AAR, APRI and FIB-4 for differential diagnosis of liver cirrhosis at compensatory stage and de-compensatory stage were 0.627, 0.666, 0.795 and 0.820, respectively.
  
  
  CONCLUSIONS
  LS, AAR, APRI and FIB-4 were good indicators as clinical diagnosis and differential diagnosis on hepatitis B related cirrhosis.
authors.affiliation: Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China.
authors.forename: Deping
authors.initials: D
authors.lastname: Ding
authors.affiliation: Department of Infectious Disease, Weinan Central Hospital Weinan 714000, China.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Kang
authors.affiliation: Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China.
authors.forename: Yinhua
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China.
authors.forename: Deqiang
authors.initials: D
authors.lastname: Ma
authors.affiliation: Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Infectious Diseases, Taihe Hospital, Hubei University of MedicineShiyan 442000, China; Institute of Biomedical Research, Taihe Hospital, Hubei University of MedicineShiyan 442000, China.
authors.forename: Zhongji
authors.initials: Z
authors.lastname: Meng
keywords: Chronic hepatitis B; cirrhosis; liver fibrosis; transient elastography