title: Chronic fatigue syndrome and sleep disorders: clinical associations and diagnostic difficulties.
abstract: BACKGROUND
  Chronic fatigue syndrome (CFS) is characterised by the presence of intractable fatigue and non-restorative sleep, symptoms which are also very prevalent in multiple diseases and appear as side effects of different drugs. Numerous studies have shown a high prevalence of sleep disorders in patients with CFS. However, non-restorative sleep and fatigue are frequently symptoms of the sleep disorders themselves, so primary sleep disorders have to be ruled out in many cases of CFS.
  
  
  METHODS
  This review was performed using a structured search of the MeSH terms ([Sleep]+[Chronic fatigue syndrome]) in the PubMed database.
  
  
  CONCLUSIONS
  Identifying primary sleep disorders in patients meeting diagnostic criteria for CFS will allow for a more comprehensive treatment approach involving new diagnostic and therapeutic strategies that may improve quality of life for these patients.
authors.affiliation: Unidad del Sueño, Servicio Neurofisiología Clínica, Hospital Quirón, Barcelona, España. Electronic address: doctorferre@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Ferré
keywords: Apnea del sueño; Chronic fatigue syndrome; Fatiga; Fatigue; Fibromialgia; Fibromyalgia; Non-restorative sleep; Sleep apnoea; Sleep disorders; Somnolence; Somnolencia; Sueño no reparador; Síndrome de fatiga crónica; Trastornos del sueño