title: Post-Transplant Membranous Nephropathy Associated with Chronic Active Antibody-Mediated Rejection and Hepatitis C Infection after Deceased Donor Renal Transplantation.
abstract: A 53-year-old woman who had undergone deceased donor kidney transplantation twice, at 35 and 43 years of age, presented with renal impairment. She was infected with hepatitis C virus (HCV). The histology of the graft kidney revealed post-transplant membranous nephropathy (MN) with podocytic infolding and antibody-mediated rejection (AMR). IgG subclass staining showed fine granular deposits of IgG1 and IgG3, but not IgG4, in the glomerular capillary walls. Panel reactive antibody scores for human leukocyte antigen class I and class II were 92.67% and 66.68%, respectively. Thus, this case of post-transplanted MN was considered to be associated with AMR and HCV infection.
authors.affiliation: Department of Nephrology, Fujita Health University School of Medicine, Japan.
authors.forename: Tomohito
authors.initials: T
authors.lastname: Doke
authors.forename: Waichi
authors.initials: W
authors.lastname: Sato
authors.forename: Kazuo
authors.initials: K
authors.lastname: Takahashi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Sigehisa
authors.initials: S
authors.lastname: Koide
authors.forename: Hitomi
authors.initials: H
authors.lastname: Sasaki
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kusaka
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Shiroki
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Hoshinaga
authors.forename: Asami
authors.initials: A
authors.lastname: Takeda
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yuzawa
authors.forename: Midori
authors.initials: M
authors.lastname: Hasegawa
mesh_terms: D005260:Female; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D006084:Graft Rejection / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007668:Kidney / Q000276:immunology / Q000473:pathology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D012086:Reoperation; D016559:Tacrolimus / Q000008:administration & dosage; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015395:Histocompatibility Antigens Class I; D007166:Immunosuppressive Agents; D011239:Prednisolone; D016559:Tacrolimus; D008775:Methylprednisolone