title: Association of lipid profile with serum PON1 concentration in patients with chronic kidney disease.
abstract: Patients with chronic kidney disease (CKD) are at high risk of atherosclerotic events; dyslipoproteinemia and the decrease of the HDL-linked enzyme paraoxonase 1 (PON1), might have a major role. This study intends to compare the association between lipid profile and serum PON1 levels in renal failure (RF) and hemodialysis (HD) patients. Serum lipids, HDL-subclasses and PON1 concentration were evaluated in 90 patients with CKD, divided into groups: RF (n = 46) and HD (n = 44), and in 30 normal individuals (control group). The results showed that PON1 was significantly lower in HD patients than in RF and controls (p < 0.001). In RF patients under statin therapy, PON1 did not differ from that of patients without statins. In HD patients without statins, PON1 was considerably low, whereas in HD with statins (30.42 ± 12.62 μg/mL) was lower than RF with statins (49.31 ± 14.94, p < 0.001). PON1 concentration was significantly and positively associated with HDL-C, HDL3-C and Apo A1 in all groups. Additionally, in HD patients PON1 was negatively associated with LDL-C. Multiple regression analysis revealed that LDL-C and statin treatment were independently related to PON1 concentration in HD patients (β =  -0.331, p = 0.026 and β = 0.344, p = 0.020, respectively). In RF patients, HDL3-C and Apo A1 are strong determinants of PON1 levels. It is concluded that different parameters of lipid profile seem to affect serum PON1 concentration of RF and HD patients and probably contribute to the delay of atherosclerosis.
authors.affiliation: a Biochemical Department , "Alexandra" Hospital , Athens , Greece.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Samouilidou
authors.affiliation: a Biochemical Department , "Alexandra" Hospital , Athens , Greece.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Kostopoulos
authors.affiliation: a Biochemical Department , "Alexandra" Hospital , Athens , Greece.
authors.forename: Augustina
authors.initials: A
authors.lastname: Liaouri
authors.affiliation: b Nephrology Department , "Aretaeio" University Hospital , Athens , Greece.
authors.forename: Eva
authors.initials: E
authors.lastname: Kioussi
authors.affiliation: c Hemodialysis Unit , "Hippokrateio" General Hospital , Athens , Greece.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Vassiliou
authors.affiliation: b Nephrology Department , "Aretaeio" University Hospital , Athens , Greece.
authors.forename: Eirini
authors.initials: E
authors.lastname: Bountou
authors.affiliation: b Nephrology Department , "Aretaeio" University Hospital , Athens , Greece.
authors.forename: Eirini
authors.initials: E
authors.lastname: Grapsa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D043303:Aryldialkylphosphatase / Q000097:blood*; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006115:Greece; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: HDL-C subclasses; hemodialysis; paraoxonase 1 concentration