title: Relationship between uric acid and blood pressure in different age groups.
abstract: BACKGROUND
  Serum uric acid (UA) has been known to have a positive association with blood pressure (BP). However, the relationship between serum UA and BP in different age groups is unclear.
  
  
  METHODS
  A total of 45,098 Koreans who underwent health examinations at Korea Association of Health Promotion with no history of taking drugs related with UA and/or BP were analyzed for determining the relationship between serum UA and BP.
  
  
  RESULTS
  In men <40, serum UA was significantly associated with systolic (β = 0.25, p = 0.002) and diastolic BP (β = 0.41, p < 0.001) after adjustment for age, diabetes, dyslipidemia, body mass index, and estimated glomerular filtration rate. Men between ages 40 and 59 showed similar results regarding diastolic BP. The association between serum UA and BP was stronger in women <40 (β = 0.54, p < 0.001 for systolic BP; β = 0.65, p < 0.001 for diastolic BP) and in between 40 and 59 (β = 0.51, p < 0.001 for diastolic BP). The association was not significant in men and women ≥60. The odds ratios (ORs) of hyperuricemia for hypertension were 1.25 (95% confidence interval [CI], 1.08 to 1.45; p = 0.003) and 1.33 (95% CI, 1.11 to 1.60; p = 0.002) in men <40 and in between 40 and 59, respectively, in the multivariate analysis. The OR was 2.60 (95% CI, 1.37 to 4.94; p = 0.0034) in women <40. The relationship between hyperuricemia and hypertension was not significant in other age/gender groups.
  
  
  CONCLUSIONS
  In contrast to the elderly of 60 and over, the non-elderly showed significant associations between serum UA and BP.
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, 152-703 Seoul, South Korea.
authors.forename: Jae Joong
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: National Evidence-based Healthcare Collaborating Agency, Seoul, South Korea.
authors.forename: Jeonghoon
authors.initials: J
authors.lastname: Ahn
authors.affiliation: National Evidence-based Healthcare Collaborating Agency, Seoul, South Korea.
authors.forename: Jinseub
authors.initials: J
authors.lastname: Hwang
authors.affiliation: Department of Cardiology, Dongtan Sacred Heart Hospital, Hallym University Medical Center, Hwaseong, South Korea.
authors.forename: Seong Woo
authors.initials: SW
authors.lastname: Han
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, 152-703 Seoul, South Korea.
authors.forename: Kwang No
authors.initials: KN
authors.lastname: Lee
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, 152-703 Seoul, South Korea.
authors.forename: Ji Bak
authors.initials: JB
authors.lastname: Kim
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, 152-703 Seoul, South Korea.
authors.forename: Sunki
authors.initials: S
authors.lastname: Lee
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, 152-703 Seoul, South Korea.
authors.forename: Jin Oh
authors.initials: JO
authors.lastname: Na
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, 152-703 Seoul, South Korea.
authors.forename: Hong Euy
authors.initials: HE
authors.lastname: Lim
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, 152-703 Seoul, South Korea.
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, 152-703 Seoul, South Korea.
authors.forename: Seung-Woon
authors.initials: SW
authors.lastname: Rha
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, 152-703 Seoul, South Korea.
authors.forename: Chang Gyu
authors.initials: CG
authors.lastname: Park
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, 152-703 Seoul, South Korea.
authors.forename: Hong Seog
authors.initials: HS
authors.lastname: Seo
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, 152-703 Seoul, South Korea.
authors.forename: Dong Joo
authors.initials: DJ
authors.lastname: Oh
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, 152-703 Seoul, South Korea.
authors.forename: Eung Ju
authors.initials: EJ
authors.lastname: Kim
keywords: Blood pressure; Hypertension; Hyperuricemia; Uric acid