title: Functional evaluation of an iridotomy in primary angle closure eyes.
abstract: OBJECTIVE
  To evaluate the functional efficacy of an iridotomy in primary angle closure (PAC) eyes by measuring IOP responses to provocative tests before and after iridotomy.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  50 consecutive adult patients, 40-60 years of age, having primary angle closure.
  
  
  METHODS
  Clinical examination, perimetry, biometry and ultrasound biomicroscopy of the angle were done. A darkroom prone provocative test (DRPPT), a mydriatic test and a Valsalva maneuver were performed before and after the iridotomy.
  
  
  METHODS
  IOP change in response to the provocative tests before and after iridotomy, and correlation with baseline parameters.
  
  
  RESULTS
  IOP at baseline and after iridotomy was 14.4 ± 2.7 mmHg and 14.3 ± 2.6 mmHg, respectively (p = 0.)83. There was no significant change on diurnal phasing before and after an iridotomy (p = 0.)11. The mean IOP rise was 5.9 ± 3.7 mmHg on the DRPPT, 4.3 ± 3.5 mmHg on the Mydriatic test and 9.1 ± 4.9 mmHg on the Valsalva maneuver, and was reduced significantly to 3.2 ± 2.1 mmHg, 2.3 ± 1.8 and 6.4 ± 3.5, respectively(p < 0.001 for all tests). The decrease in pupillary block component for all 50 eyes was 46.5 % for the mydriatic test, 45.8 % for the DRPPT and 29.7 % for the Valsalva maneuver. PAC eyes positive on the DRPPT and mydriatic test prior to an iridotomy became negative after laser iridotomy in 75.9 and 84.6 % eyes, respectively, but on the Valsalva maneuver, only 23.8 % became negative. After iridotomy, eyes that continued to be positive on the mydriatic test had a significantly thicker lens (p = 0.02), decreased TCPD (p = 0.014) and narrower trabecular-iris angle (p = 0.048). On the DRPPT, they had a thicker lens (p = 0.03), shorter iris thickness (p = 0.025) and TCPD (p = 0.032), and on the Valsalva maneuver, they had a narrower scleral-ciliary process angle (SCPA; p = 0.019) and shorter TCPD (p = 0.015).
  
  
  CONCLUSIONS
  This comprehensive functional evaluation of laser iridotomy in early PAC eyes showed a significant reduction in the pupillary block component of IOP response to provocative testing, possibly decreasing IOP fluctuations over time. An iridotomy does not, however, significantly change mean IOP or diurnal phasing of IOP in PAC eyes. Eyes with a very narrow angle or a thick lens may continue to have angle closure due to other pathomechanisms for angle closure.
authors.affiliation: Glaucoma Research Facility & Clinical Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India. rjsihota@gmail.com.
authors.forename: Ramanjit
authors.identifier: http://orcid.org/0000-0002-0986-5954
authors.initials: R
authors.lastname: Sihota
authors.affiliation: Glaucoma Research Facility & Clinical Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Karandeep
authors.initials: K
authors.lastname: Rishi
authors.affiliation: Glaucoma Research Facility & Clinical Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Geetha
authors.initials: G
authors.lastname: Srinivasan
authors.affiliation: Glaucoma Research Facility & Clinical Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Viney
authors.initials: V
authors.lastname: Gupta
authors.affiliation: Glaucoma Research Facility & Clinical Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Tanuj
authors.initials: T
authors.lastname: Dada
authors.affiliation: Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Kulwant
authors.initials: K
authors.lastname: Singh
mesh_terms: D000328:Adult; D001699:Biometry; D015331:Cohort Studies; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000503:physiopathology / Q000601:surgery*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D032801:Iridectomy; D007498:Iris / Q000601:surgery*; D053685:Laser Therapy; D053844:Lasers, Solid-State / Q000627:therapeutic use; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D011446:Prospective Studies; D011681:Pupil Disorders / Q000503:physiopathology; D014065:Tonometry, Ocular; D014636:Valsalva Maneuver / Q000502:physiology; D058609:Visual Field Tests
keywords: Functional evaluation; Laser iridotomy; PAC; Pupillary block component