title: A Proposal for the Optimal Management Target for Serum Non-High-Density Lipoprotein Cholesterol Level in Low-Risk Japanese Workers.
abstract: OBJECTIVE
  The Japan Atherosclerosis Society Guidelines for the Diagnosis and Prevention of Atherosclerotic Cardiovascular Diseases 2012 (JAS Guidelines 2012) indicate that the management target for serum non-high-density lipoprotein cholesterol (non-HDLC) level is 30 mg/dL higher than that for low-density lipoprotein cholesterol (LDLC) level. However, it remains unclear whether this value is applicable to subjects at a low risk of cardiovascular disease. This study aimed to propose the optimal management target for serum non-HDLC level in low-risk Japanese subjects.
  
  
  METHODS
  Among 20,909 subjects who underwent annual medical checkup at a Japanese company in 2008, we analyzed the data of 17,023 subjects (14,352 men, mean age 37.8±8.6 years) in risk category I according to the JAS Guidelines 2012. The correlation between LDLC and non-HDLC levels was examined.
  
  
  RESULTS
  A strong correlation was found between LDLC and non-HDLC levels (r=0.95, p<0.001). The following regression equation for calculation of non-HDLC was obtained from linear regression analysis: non-HDLC (mg/dL)=1.09×LDLC (mg/dL)＋7.79. According to this equation, the optimal management target for non-HDLC level corresponding to that for LDLC level (160 mg/dL) was 180 mg/dL. A multiple logistic regression analysis revealed that age, obesity, habitual alcohol intake, and current smoking were significantly associated with non-HDLC ≥180 mg/dL.
  
  
  CONCLUSIONS
  The management target for non-HDLC level is recommended to be set at 20 mg/dL higher than that for the LDLC level (i.e., 180 mg/dL) in low-risk Japanese subjects.
authors.affiliation: Department of Hygiene and Public Health, Graduate School of Medicine, Nippon Medical School.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Saiki
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Otsuka
authors.forename: Katsuhito
authors.initials: K
authors.lastname: Kato
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kawada
mesh_terms: D000293:Adolescent; D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000517:prevention & control*; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D019468:Disease Management; D005260:Female; D006293:Health Promotion / Q000379:methods; D006801:Humans; D007564:Japan; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D016272:Occupational Health; D012044:Regression Analysis; D012307:Risk Factors; D055815:Young Adult
chemical_list: D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; D002784:Cholesterol