title: Familial Hypercholesterolemia.
abstract: Familial hypercholesterolemia is a common, inherited disorder of cholesterol metabolism that leads to early cardiovascular morbidity and mortality. It is underdiagnosed and undertreated. Statins, ezetimibe, bile acid sequestrants, niacin, lomitapide, mipomersen, and low-density lipoprotein (LDL) apheresis are treatments that can lower LDL cholesterol levels. Early treatment can lead to substantial reduction of cardiovascular events and death in patients with familial hypercholesterolemia. It is important to increase awareness of this disorder in physicians and patients to reduce the burden of this disorder.
authors.affiliation: Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, Campus Box 8127, 660 South Euclid, St Louis, MO 63110, USA.
authors.forename: Victoria Enchia
authors.initials: VE
authors.lastname: Bouhairie
authors.affiliation: Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, Campus Box 8127, 660 South Euclid, St Louis, MO 63110, USA. Electronic address: agoldber@dom.wustl.edu.
authors.forename: Anne Carol
authors.initials: AC
authors.lastname: Goldberg
keywords: Bile acid sequestrants; Ezetimibe; Familial hypercholesterolemia; LDL apheresis; Lomitapide; Mipomersen; Statins