title: Chromosome Aberrations and Fertility Disorders in Domestic Animals.
abstract: The association between chromosomal abnormalities and reduced fertility in domestic animals is well recorded and has been studied for decades. Chromosome aberrations directly affect meiosis, gametogenesis, and the viability of zygotes and embryos. In some instances, balanced structural rearrangements can be transmitted, causing fertility problems in subsequent generations. Here, we aim to give a comprehensive overview of the current status and future prospects of clinical cytogenetics of animal reproduction by focusing on the advances in molecular cytogenetics during the genomics era. We describe how advancing knowledge about animal genomes has improved our understanding of connections between gross structural or molecular chromosome variations and reproductive disorders. Further, we expand on a key area of reproduction genetics: cytogenetics of animal gametes and embryos. Finally, we describe how traditional cytogenetics is interfacing with advanced genomics approaches, such as array technologies and next-generation sequencing, and speculate about the future prospects.
authors.affiliation: Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas 77843-4458; email: traudsepp@cvm.tamu.edu.
authors.forename: Terje
authors.initials: T
authors.lastname: Raudsepp
authors.affiliation: New Research Complex, Qatar University, Al Tarfa, Doha 2713, Qatar; email: bchowdhary@qu.edu.qa.
authors.forename: Bhanu P
authors.initials: BP
authors.lastname: Chowdhary
mesh_terms: D000818:Animals; D000829:Animals, Domestic; D002415:Cats; D002417:Cattle; D002869:Chromosome Aberrations / Q000196:embryology / Q000662:veterinary*; D055028:Comparative Genomic Hybridization; D003582:Cytogenetics; D004285:Dogs; D005298:Fertility / Q000235:genetics; D005718:Gametogenesis / Q000235:genetics; D023281:Genomics; D006041:Goats; D059014:High-Throughput Nucleotide Sequencing; D006736:Horses; D007246:Infertility / Q000235:genetics / Q000662:veterinary*; D008540:Meiosis / Q000235:genetics; D012098:Reproduction / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012756:Sheep
keywords: CGH; NGS; comparative genomic hybridization; cytogenetics; embryos; gametes; next-generation sequencing; reproduction