title: [Management and Outcome of Surgery in Patients with Severe Pulmonary Hypertension--A Single-Center Experience].
abstract: BACKGROUND
  Patients with pulmonary hypertension (PH) are at high risk when undergoing surgery. Up to one-third of patients suffer complications; recent studies report a mortality rate of 1 to 7%. Frequent events are deterioration of right heart function and infectious or bleeding complications.
  
  
  METHODS
  Data of patients (age ≥ 18) with precapillary PH who need to undergo elective surgery between January 2006 and March 2015 were included in this retrospective analysis. All patients who were planned for surgery underwent the same procedure. First, patients were evaluated in the PH center. Thereafter, PH-relevant data were discussed with the surgeon/anesthesiologist team for risk-adapted planning of anesthesia and intervention. The present analysis comprises patient characteristics and information about surgery and post-interventional course.
  
  
  RESULTS
  This study analyzes 31 surgical procedures carried out in PH patients (male: n = 8; PH-group I: n = 23, group III: n = 3, group IV: n = 5, mean age: 59.5 ± 15.3 years). Patients were characterized by compromised hemodynamics and exercise capacity: pulmonary vascular resistance: 805.4 ± 328.5 dyn*s*cm(-5), mean pulmonary arterial pressure: 46.3 ± 9.3 mmHg, 6-minute walking distance: 350.3 ± 123.3 m.The majority of interventions were performed under general anesthesia (n = 24). In 25 cases, the intraoperative monitoring was complemented with right heart catheterization.Eight interventions were associated with complications, three of which were serious. One patient died postoperatively owing to sepsis and right heart failure.
  
  
  CONCLUSIONS
  A careful and structured planning of surgical interventions in patients with PH and the choice of surgical procedure and anesthesia adapted to the conditions of PH might help avoid complications. Further multicentric studies are needed.
authors.affiliation: Abteilung Pneumologie; Department Innere Medizin, Neurologie und Dermatologie; Universitätsklinikum Leipzig AöR.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Seyfarth
authors.affiliation: Abteilung Pneumologie; Department Innere Medizin, Neurologie und Dermatologie; Universitätsklinikum Leipzig AöR.
authors.forename: H
authors.initials: H
authors.lastname: Wirtz
authors.affiliation: Klinik für Anästhesiologie, Intensiv- und Schmerztherapie; Klinikum St. Georg Leipzig gGmbH.
authors.forename: J
authors.initials: J
authors.lastname: Gille
authors.affiliation: Klinik für Anästhesiologie, Intensiv- und Schmerztherapie; Klinikum St. Georg Leipzig gGmbH.
authors.forename: S
authors.initials: S
authors.lastname: Gerlach
authors.affiliation: Abteilung Pneumologie; Department Innere Medizin, Neurologie und Dermatologie; Universitätsklinikum Leipzig AöR.
authors.forename: S
authors.initials: S
authors.lastname: Grachtrup
authors.affiliation: Praxis für Pneumologie/Allergologie Leipzig.
authors.forename: J
authors.initials: J
authors.lastname: Winkler
authors.affiliation: Klinik für Anästhesiologie, Intensiv- und Schmerztherapie; Klinikum St. Georg Leipzig gGmbH.
authors.forename: A
authors.initials: A
authors.lastname: Sablotzki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005858:Germany; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000401:mortality* / Q000517:prevention & control*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000401:mortality* / Q000706:statistics & numerical data*