title: Association of genetic polymorphisms in PTEN and additional interaction with alcohol consumption and smoking on colorectal cancer in Chinese population.
abstract: OBJECTIVE
  To investigate the association of phosphatase and tensin homologue deleted on chromosome ten (PTEN) gene rs3830675, and additional interaction with drinking and smoking on colorectal cancer (CRC), based on a hospital based Chinese case-control study.
  
  
  METHODS
  A total of 850 subjects (413 males and 437 females) were studied, including 422 colorectal cancer cases and 428 controls. Rs3830675 was selected for genotyping in the case-control study. Logistic regression model was used to examine the association between rs3830675 and colorectal cancer, and additional interaction with alcohol consumption and smoking.
  
  
  RESULTS
  The frequencies for rs3830675 (-) alleles was higher in cases than that in controls, (-) allele of rs3830675 was 24.4% in controls and 29.4% in CRC subjects (p=0.005). Logistic analysis showed that the carriers of (-) allele of rs3830675 revealed increased CRC risk than those with (+/+) genotype, adjusted OR (95% CI) was 1.35(1.12-1.98). We found a significant interaction between alcohol consumption and rs3830675, drinkers with (-/-) or (-/+) of rs3830675 genotype have highest colorectal cancer risk, compared to never drinking subjects with (+/+) genotype, OR (95% CI) was 2.57 (1.66-3.33), after covariates adjustment. In addition, we also found that smokers with (-/-) or (-/+) of rs3830675 genotype have highest colorectal cancer risk, compared to never smokers with (+/+) genotype, OR (95% CI) was 3.01 (1.58-6.05).
  
  
  CONCLUSIONS
  The (-) allele of rs3830675 was positively with colorectal cancer risk. There was a significant role of interaction of rs3830675 with alcohol consumption and smoking on colorectal cancer.
authors.affiliation: Department of General Surgery, Henan Provincial People's Hospital Zhengzhou 450000, China.
authors.forename: Mingyang
authors.initials: M
authors.lastname: Han
authors.affiliation: Department of General Surgery, Henan Provincial People's Hospital Zhengzhou 450000, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.affiliation: Department of General Surgery, Henan Provincial People's Hospital Zhengzhou 450000, China.
authors.forename: Peichun
authors.initials: P
authors.lastname: Sun
authors.affiliation: Department of General Surgery, Henan Provincial People's Hospital Zhengzhou 450000, China.
authors.forename: Jiewei
authors.initials: J
authors.lastname: Nie
authors.affiliation: Department of General Surgery, Henan Provincial People's Hospital Zhengzhou 450000, China.
authors.forename: Jiancheng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Reproductive Institute, Henan Provincial People's Hospital Zhengzhou 450000, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
keywords: Colorectal cancer; PTEN gene; SNP; drinking; interaction