title: Anamnestic responses in pigs to the Taenia solium TSOL18 vaccine and implications for control strategies.
abstract: Specific antibody responses were assessed in pigs immunized with the Taenia solium vaccine TSOL18. Anti-TSOL18 responses were compared 2 weeks after secondary immunization, where the interval between primary and secondary immunization was 4, 8, 12, 16 or 20 weeks. All animals responded to the vaccine and there was no diminution in antibody responses in animals receiving their second injection after an interval up to 20 weeks. Pigs receiving vaccinations at an interval of 12 weeks developed significantly increased antibody responses compared with animals receiving immunizations 4 weeks apart (P = 0.046). The ability to deliver TSOL18 vaccination effectively where the revaccination schedule can be delayed for up to 12-16 weeks in pigs increases the options available for designing T. solium control interventions that incorporate TSOL18 vaccination.
authors.affiliation: Faculty of Veterinary and Agricultural Sciences,The University of Melbourne,Veterinary Clinical Centre,250 Princes Highway,Werribee,Victoria 3030,Australia.
authors.forename: Marshall W
authors.initials: MW
authors.lastname: Lightowlers
authors.affiliation: Faculty of Veterinary and Agricultural Sciences,The University of Melbourne,Veterinary Clinical Centre,250 Princes Highway,Werribee,Victoria 3030,Australia.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Donadeu
authors.affiliation: Indian Immunologicals Limited,'Rakshapuram',Gachibowli Post,Hyderabad - 500 032,Telangana,India.
authors.forename: M
authors.initials: M
authors.lastname: Elaiyaraja
authors.affiliation: Indian Immunologicals Limited,'Rakshapuram',Gachibowli Post,Hyderabad - 500 032,Telangana,India.
authors.forename: Kapil
authors.initials: K
authors.lastname: Maithal
authors.affiliation: Indian Immunologicals Limited,'Rakshapuram',Gachibowli Post,Hyderabad - 500 032,Telangana,India.
authors.forename: K Anand
authors.initials: KA
authors.lastname: Kumar
authors.affiliation: Faculty of Veterinary and Agricultural Sciences,The University of Melbourne,Veterinary Clinical Centre,250 Princes Highway,Werribee,Victoria 3030,Australia.
authors.forename: Charles G
authors.initials: CG
authors.lastname: Gauci
authors.affiliation: Faculty of Veterinary and Agricultural Sciences,Asia-Pacific Centre for Animal Health,The University of Melbourne,Parkville,Victoria 3010,Australia.
authors.forename: Simon M
authors.initials: SM
authors.lastname: Firestone
authors.affiliation: Ondax Scientific SL,Aptdo. 336,20280 Hondarribia,Spain.
authors.forename: Patxi
authors.initials: P
authors.lastname: Sarasola
authors.affiliation: GALVmed,Doherty Building,Pentlands Science Park,Bush Loan,Edinburgh EH26 0PZ,Scotland,UK.
authors.forename: Tim G
authors.initials: TG
authors.lastname: Rowan
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis / Q000097:blood*; D005260:Female; D007115:Immunization Schedule; D007117:Immunization, Secondary / Q000592:standards / Q000662:veterinary*; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control*; D041201:Taenia solium / Q000276:immunology*; D013622:Taeniasis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D013997:Time Factors; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D014612:Vaccines
keywords: TSOL18; Taenia solium; anamnestic response; pig; vaccine