title: Treatment of severe thyroid function disorders and changes in body composition.
abstract: BACKGROUND
  Hyper- and hypothyroidism are accompanied by altered metabolic rate, thermogenesis, and body weight. The aim of this study was to estimate the relation between treatment-induced changes in thyroid function, and the accompanying body composition in patients with either severe hypo- or hyperthyroidism.
  
  
  METHODS
  Body composition analysis and hormonal assessment were measured at the initial diagnosis of thyroid disorder, after three-month treatment, and finally after complete recovery from hyperthyroidism (n = 18) or hypothyroidism (n = 27). Nonparametric Spearman correlation was used to analyse the relation between thyroid hormones and body composition as well as their respective changes.
  
  
  RESULTS
  In hypothyroid patients applied treatment significantly reduced (p < 0.05) total body weight, mainly due to a decrease in fat mass, whereas in hyperthyroid patients it caused a weight gain, with a simultaneous increase in muscle, water and fat mass. Total body weight and fat mass were significantly correlated with thyroid hormones' concentrations in all patients. Changes of fat, water, or muscle mass were strongly correlated with the changes in the patients' hormonal status.
  
  
  CONCLUSIONS
  Body composition is related to the concentration of thyroid hormones in thyroid dysfunction. Treatment-induced changes in thyroid hormones concentrations are correlated with the magnitude of the change of body weight, including muscle, water, and fat amount. (Endokrynol Pol 2016; 67 (4): 359-366).
authors.forename: Adam
authors.initials: A
authors.lastname: Stangierski
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences. mruchala@ump.edu.pl.
authors.forename: Marek
authors.initials: M
authors.lastname: Ruchała
authors.forename: Tomasz
authors.initials: T
authors.lastname: Krauze
authors.forename: Jerzy
authors.initials: J
authors.lastname: Moczko
authors.forename: Przemysław
authors.initials: P
authors.lastname: Guzik
mesh_terms: D000328:Adult; D001823:Body Composition; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D007037:Hypothyroidism / Q000097:blood / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000378:metabolism* / Q000503:physiopathology; D013963:Thyroid Hormones / Q000097:blood*
chemical_list: D013963:Thyroid Hormones
keywords: body composition; body mass; hyperthyroidism; hypothyroidism