title: Expression of SKA1 and MMP-9 in primary salivary adenoid cystic carcinoma: Correlation with tumor progression and patient prognosis.
abstract: Conclusion The spindle and kinetochore-associated complex sub unit 1(SKA1) and matrix metalloproteinase-9 (MMP-9) are highly expressed in salivary adenoid cystic carcinoma (SACC), and SKA1 may be the novel, promising prognostic factor for clinical outcomes in head and neck adenoid cystic carcinoma patients. Objectives This study aimed to investigate the expression of SKA1 and MMP-9 in SACC tissues and the clinical significance. Methods SKA1 and MMP-9 expression in samples from 42 cases of SACC and 20 subjects with the normal tissue adjacent to carcinoma were detected by immunohistochemical analysis. Results The positive rate of SKA1 and MMP-9 staining was 78.6% and 66.7% in SACC, respectively, significantly higher than in normal salivary gland tissues (p < 0.001). Chi-square test showed that there was no significant correlation between SKA1 expression and MMP-9 expression in SACC tissues. However, SKA1 and MMP-9 expression was positively associated with advanced stage and solid histological pattern of SACC (p < 0.05). In addition, SKA1 and MMP-9 expression was positively associated with recurrence and perineural invasion, and survival time, respectively.
authors.affiliation: a School of Stomatology , Shandong University , Jinan , PR China ;|b Yantai Stomatological Hospital Affiliated to Binzhou Medical College , Yantai , PR China ;
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhao
authors.affiliation: c Department of Oral and Maxillofacial Surgery , Liaocheng People's Hospital , Liaocheng , PR China.
authors.forename: Licheng
authors.initials: L
authors.lastname: Jiang
authors.affiliation: b Yantai Stomatological Hospital Affiliated to Binzhou Medical College , Yantai , PR China ;
authors.forename: Pinggong
authors.initials: P
authors.lastname: Du
authors.affiliation: c Department of Oral and Maxillofacial Surgery , Liaocheng People's Hospital , Liaocheng , PR China.
authors.forename: Dongyan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: b Yantai Stomatological Hospital Affiliated to Binzhou Medical College , Yantai , PR China ;
authors.forename: Zhonghao
authors.initials: Z
authors.lastname: Liu
authors.affiliation: c Department of Oral and Maxillofacial Surgery , Liaocheng People's Hospital , Liaocheng , PR China.
authors.forename: Keyi
authors.initials: K
authors.lastname: Li
authors.affiliation: a School of Stomatology , Shandong University , Jinan , PR China ;|c Department of Oral and Maxillofacial Surgery , Liaocheng People's Hospital , Liaocheng , PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
mesh_terms: D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D002868:Chromosomal Proteins, Non-Histone; C516427:SKA1 protein, human; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
keywords: SACC; Spindle and kinetochore-associated complex sub-unit 1; matrix metalloproteinase-9; metastasis