title: Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae.
abstract: Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in children and vulnerable populations such as the elderly and those with chronic obstructive pulmonary disease (COPD). One NTHi protein is included in a pneumococcal conjugate vaccine and has been shown to provide efficacy. Our lab has been interested in understanding the immunogenicity of NTHi vaccine candidates P6, protein D and OMP26 for preventing acute otitis media in young children. We expect that continued investigation and progress in the development of an efficacious protein based vaccine against NTHi infections is achievable in the near future.
authors.affiliation: a Center for Infectious Disease and Immunology , Rochester General Hospital Research Institute , Rochester , NY , USA.
authors.forename: M Nadeem
authors.initials: MN
authors.lastname: Khan
authors.affiliation: a Center for Infectious Disease and Immunology , Rochester General Hospital Research Institute , Rochester , NY , USA.
authors.forename: Dabin
authors.initials: D
authors.lastname: Ren
authors.affiliation: a Center for Infectious Disease and Immunology , Rochester General Hospital Research Institute , Rochester , NY , USA.
authors.forename: Ravinder
authors.initials: R
authors.lastname: Kaur
authors.affiliation: a Center for Infectious Disease and Immunology , Rochester General Hospital Research Institute , Rochester , NY , USA.
authors.forename: Saleem
authors.initials: S
authors.lastname: Basha
authors.affiliation: a Center for Infectious Disease and Immunology , Rochester General Hospital Research Institute , Rochester , NY , USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Zagursky
authors.affiliation: a Center for Infectious Disease and Immunology , Rochester General Hospital Research Institute , Rochester , NY , USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Pichichero
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology; D055808:Drug Discovery / Q000639:trends; D006192:Haemophilus Infections / Q000517:prevention & control*; D018073:Haemophilus Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D010033:Otitis Media / Q000517:prevention & control*; D022223:Vaccines, Subunit / Q000276:immunology / Q000302:isolation & purification
chemical_list: D000942:Antigens, Bacterial; D018073:Haemophilus Vaccines; D022223:Vaccines, Subunit
keywords: Haemophilus influenzae; Nontypeable Haemophilus influenzae; Streptococcus pneumoniae; conjugate vaccine; otitis media