title: [Intravitreal dexamethasone implant for treatment of persistent postoperative macular edema after vitrectomy].
abstract: BACKGROUND
  To date, there is no consensus about the management of persistent cystoid macular edema (CME) following vitrectomy. The aim of this study was to evaluate the efficacy and safety of intravitreal dexamethasone implants for the treatment of postoperative CME following vitrectomy.
  
  
  METHODS
  In this multicenter study we retrospectively reviewed the data of 24 patients (25 eyes) who had been treated with intravitreal dexamethasone (Ozurdex®) for the management of persistent postoperative CME following pars plana vitrectomy. The main outcome measure was central retinal thickness (CRT in µm) as assessed by spectral domain optical coherence tomography (SD-OCT). Secondary outcome measures included change in best corrected visual acuity (BCVA) and the presence of metamorphopsia.
  
  
  RESULTS
  All 19 eyes which were postoperatively examined within 4-8 weeks after implantation showed a significant decrease in CRT (mean 564 µm to 315 µm) and a reduction of metamorphopsias. Within the same period of time the BCVA improved in 15 out of 19 eyes (79%) which corresponds to an average visual improvement from 0.69 logMAR to 0.46 logMAR (P <0.0001). In eyes examined after 10-16 weeks a slight increase in the average CRT of 351 µm was observed, whereas the BCVA improved to 0.28 logMAR. After 4 months a decrease in average BCVA was noted. Out of 25 eyes 12 required further dexamethasone implantations between 1 and 4 times within the investigation period. The first repeat injections were performed an average of 7.3 months after the initial treatment.
  
  
  CONCLUSIONS
  Our results suggest that intravitreal dexamethasone is a safe and effective treatment option for persistent CME following vitrectomy.
authors.affiliation: Augenklinik des Klinikums Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Deutschland. hattenbach.lo@klilu.de.
authors.forename: L-O
authors.initials: LO
authors.lastname: Hattenbach
authors.affiliation: Klinik für Augenheilkunde, Goethe-Universität, Frankfurt am Main, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Kuhli-Hattenbach
authors.affiliation: Augenklinik des Klinikums Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Springer
authors.affiliation: Klinik für Augenheilkunde, Universitätsmedizin Göttingen, Göttingen, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Callizo
authors.affiliation: Klinik für Augenheilkunde, Universitätsmedizin Göttingen, Göttingen, Deutschland.
authors.forename: H
authors.initials: H
authors.lastname: Hoerauf
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy*; D012160:Retina / Q000187:drug effects; D019233:Retreatment; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014786:Vision Disorders / Q000175:diagnosis / Q000188:drug therapy; D014792:Visual Acuity / Q000187:drug effects; D014821:Vitrectomy
chemical_list: D004343:Drug Implants; D003907:Dexamethasone
keywords: Central retinal thickness; Metamorphopsias; Optical coherence tomography; Vision; Visual acuity