title: The amygdalo-nigrostriatal network is critical for an optimal temporal performance.
abstract: The amygdalo-nigrostriatal (ANS) network plays an essential role in enhanced attention to significant events. Interval timing requires attention to temporal cues. We assessed rats having a disconnected ANS network, due to contralateral lesions of the medial central nucleus of the amygdala (CEm) and dopaminergic afferents to the lateral striatum, as compared to controls (sham and ipsilateral lesions of CEm and dopaminergic afferents to LS) in a temporal bisection task. ANS disconnection induced poorer temporal precision and increased response latencies to a short duration. The present results reveal a role of the ANS network in temporal processing.
authors.affiliation: Université Paris-Saclay, Univ Paris-Sud, CNRS, UMR9197, Institut des Neurosciences Paris-Saclay, F 91405, Orsay, France CNRS, Orsay, F-91405 UMR 9197, Orsay, France.
authors.forename: Mouna
authors.initials: M
authors.lastname: Es-seddiqi
authors.affiliation: Université Paris-Saclay, Univ Paris-Sud, CNRS, UMR9197, Institut des Neurosciences Paris-Saclay, F 91405, Orsay, France CNRS, Orsay, F-91405 UMR 9197, Orsay, France.
authors.forename: Nicole
authors.initials: N
authors.lastname: El Massioui
authors.affiliation: Université Paris-Saclay, Univ Paris-Sud, CNRS, UMR9197, Institut des Neurosciences Paris-Saclay, F 91405, Orsay, France CNRS, Orsay, F-91405 UMR 9197, Orsay, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Samson
authors.affiliation: Department of Psychology, Queens College, Flushing, New York 11367, USA Graduate Center, City University of New York, New York, New York 10016, USA.
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Brown
authors.affiliation: Université Paris-Saclay, Univ Paris-Sud, CNRS, UMR9197, Institut des Neurosciences Paris-Saclay, F 91405, Orsay, France CNRS, Orsay, F-91405 UMR 9197, Orsay, France valerie.doyere@u-psud.fr.
authors.forename: Valérie
authors.initials: V
authors.lastname: Doyère
mesh_terms: D000818:Animals; D066274:Central Amygdaloid Nucleus / Q000502:physiology*; D002755:Choice Behavior / Q000502:physiology; D003342:Corpus Striatum / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology; D059290:Dopaminergic Neurons / Q000502:physiology*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012054:Reinforcement, Psychology; D013997:Time Factors; D013998:Time Perception / Q000502:physiology*