title: OCT-based label-free in vivo lymphangiography within human skin and areola.
abstract: Due to the limitations of current imaging techniques, visualization of lymphatic capillaries within tissue in vivo has been challenging. Here, we present a label-free high resolution optical coherence tomography (OCT) based lymphangiography (OLAG) within human skin in vivo. OLAG enables rapid (~seconds) mapping of lymphatic networks, along with blood vessel networks, over 8 mm x 8 mm of human skin and 5 mm x 5 mm of human areola. Moreover, lymphatic system's response to inflammation within human skin is monitored throughout an acne lesion development over 7 days. The demonstrated results promise OLAG as a revolutionary tool in the clinical research and treatment of patients with pathologic conditions such as cancer, diabetes, and autoimmune diseases.
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA, USA.|Department of Electrical Engineering, University of Washington, Seattle, WA, USA.
authors.forename: Utku
authors.initials: U
authors.lastname: Baran
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA, USA.
authors.forename: Wan
authors.initials: W
authors.lastname: Qin
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA, USA.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of Dermatology, Yıldırım Beyazıt University, Ankara, Turkey.
authors.forename: Goknur
authors.initials: G
authors.lastname: Kalkan
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA, USA.
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
mesh_terms: D006801:Humans; D008220:Lymphography / Q000379:methods; D009558:Nipples; D012867:Skin; D041623:Tomography, Optical Coherence / Q000379:methods