title: Bayesian reclassification statistics for assessing improvements in diagnostic accuracy.
abstract: We propose a Bayesian approach to the estimation of the net reclassification improvement (NRI) and three versions of the integrated discrimination improvement (IDI) under the logistic regression model. Both NRI and IDI were proposed as numerical characterizations of accuracy improvement for diagnostic tests and were shown to retain certain practical advantage over analysis based on ROC curves and offer complementary information to the changes in area under the curve. Our development is a new contribution towards Bayesian solution for the estimation of NRI and IDI, which eases computational burden and increases flexibility. Our simulation results indicate that Bayesian estimation enjoys satisfactory performance comparable with frequentist estimation and achieves point estimation and credible interval construction simultaneously. We adopt the methodology to analyze a real data from the Singapore Malay Eye Study. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, 75390, TX, U.S.A.|Department of Statistics and Applied Probability, National University of Singapore, Singapore.|Singapore Eye Research Institute, Singapore.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Statistics and Applied Probability, National University of Singapore, Singapore.|Singapore Eye Research Institute, Singapore.|Duke-NUS Graduate Medical School, Singapore.
authors.forename: Jialiang
authors.identifier: 0000-0002-9704-4135
authors.initials: J
authors.lastname: Li
authors.affiliation: Singapore Eye Research Institute, Singapore.|Duke-NUS Graduate Medical School, Singapore.
authors.forename: Ching-Yu
authors.initials: CY
authors.lastname: Cheng
authors.affiliation: Singapore Eye Research Institute, Singapore.|Duke-NUS Graduate Medical School, Singapore.|Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Carol
authors.initials: C
authors.lastname: Cheung
authors.affiliation: Singapore Eye Research Institute, Singapore.|Duke-NUS Graduate Medical School, Singapore.
authors.forename: Tien-Yin
authors.initials: TY
authors.lastname: Wong
mesh_terms: D001499:Bayes Theorem; D003955:Diagnostic Tests, Routine; D016015:Logistic Models; D012372:ROC Curve
keywords: Bayesian estimation; biomarker evaluation; integrated discrimination improvement; logistic regression; net reclassification improvement