title: In vivo deep tissue imaging using wavefront shaping optical coherence tomography.
abstract: Multiple light scattering in tissue limits the penetration of optical coherence tomography (OCT) imaging. Here, we present in vivo OCT imaging of a live mouse using wavefront shaping (WS) to enhance the penetration depth. A digital micromirror device was used in a spectral-domain OCT system for complex WS of an incident beam which resulted in the optimal delivery of light energy into deep tissue. Ex vivo imaging of chicken breasts and mouse ear tissues showed enhancements in the strength of the image signals and the penetration depth, and in vivo imaging of the tail of a live mouse provided a multilayered structure inside the tissue.
authors.affiliation: Korea Advanced Institute of Science and Technology, Department of Physics, Daejeon 34141, Republic of KoreabKI for optical Science and Technology, Daejeon 34141, Republic of Korea.
authors.forename: Hyeonseung
authors.initials: H
authors.lastname: Yu
authors.affiliation: KI for optical Science and Technology, Daejeon 34141, Republic of KoreacKorea Advanced Institute of Science and Technology, Department of Bio and Brain Engineering, Daejeon 34141, Republic of Korea.
authors.forename: Peter
authors.initials: P
authors.lastname: Lee
authors.affiliation: Korea Advanced Institute of Science and Technology, Department of Physics, Daejeon 34141, Republic of KoreabKI for optical Science and Technology, Daejeon 34141, Republic of Korea.
authors.forename: KyeoReh
authors.initials: K
authors.lastname: Lee
authors.affiliation: Samsung Advanced Institute of Technology, Suwon, Gyeonggi 16678, Republic of Korea.
authors.forename: Jaeduck
authors.initials: J
authors.lastname: Jang
authors.affiliation: Samsung Electronics, Suwon, Gyeonggi 16677, Republic of Korea.
authors.forename: Jaeguyn
authors.initials: J
authors.lastname: Lim
authors.affiliation: Samsung Electronics, Suwon, Gyeonggi 16677, Republic of Korea.
authors.forename: Wooyoung
authors.initials: W
authors.lastname: Jang
authors.affiliation: KI for optical Science and Technology, Daejeon 34141, Republic of KoreacKorea Advanced Institute of Science and Technology, Department of Bio and Brain Engineering, Daejeon 34141, Republic of Korea.
authors.forename: Yong
authors.initials: Y
authors.lastname: Jeong
authors.affiliation: Korea Advanced Institute of Science and Technology, Department of Physics, Daejeon 34141, Republic of KoreabKI for optical Science and Technology, Daejeon 34141, Republic of KoreafTomocube, Inc., Daejeon 34051, Republic of Korea.
authors.forename: YongKeun
authors.initials: Y
authors.lastname: Park
mesh_terms: D000818:Animals; D002645:Chickens; D004423:Ear / Q000502:physiology; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D051379:Mice; D009132:Muscles / Q000502:physiology; D012542:Scattering, Radiation; D012815:Signal Processing, Computer-Assisted; D041623:Tomography, Optical Coherence / Q000379:methods*