title: Factors Associated with the Success of In Vitro Fertilization in Women with Inflammatory Bowel Disease.
abstract: It is unknown whether certain factors are associated with the success of in vitro fertilization (IVF) in women with inflammatory bowel disease (IBD).
  
  
  
  This study assessed whether certain characteristics are associated with greater success of live birth following IVF.
  
  
  
  In a cohort study of 8684 women with IBD seen at two tertiary care centers, we identified 121 women with IBD who underwent IVF. We assessed the effect of numerous factors on likelihood of achieving live birth after IVF.
  
  
  
  Seventy-one patients with ulcerative colitis (UC) and 49 patients with Crohn's disease (CD) were analyzed. Patients with UC who achieved a live birth were younger (p = 0.03), had a shorter duration of disease (p = 0.01), and were more likely to be in remission (p = 0.03) versus those who did not achieve live birth. Patients with CD who achieved live birth were younger (p < 0.001), had lower body mass index (BMI) (p = 0.02), and had lower cycle day 3 follicle-stimulating hormone levels (p = 0.02). There was no difference in likelihood of achieving live birth among patients in remission and those with mild or unknown disease status (p = 0.69), though most CD patients (79.5 %) were in remission. Prior surgery was not associated with live birth in patients with UC (p = 0.31) or CD (p = 0.62).
  
  
  
  As in the general infertility population, younger patients and those with lower BMI were more likely to achieve live birth. History of surgery was not associated with live birth among IBD patients. This is important information for practitioners counseling IBD patients.
authors.affiliation: Department of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, MA, USA.|Harvard Medical School, Boston, MA, USA.
authors.forename: Sveta Shah
authors.initials: SS
authors.lastname: Oza
authors.affiliation: Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Pabby
authors.affiliation: Harvard Medical School, Boston, MA, USA.|Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Dodge
authors.affiliation: Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.|Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA.
authors.forename: Michele R
authors.initials: MR
authors.lastname: Hacker
authors.affiliation: Harvard Medical School, Boston, MA, USA.|Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Janis H
authors.initials: JH
authors.lastname: Fox
authors.affiliation: Harvard Medical School, Boston, MA, USA.|Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Vasiliki A
authors.initials: VA
authors.lastname: Moragianni
authors.affiliation: Harvard Medical School, Boston, MA, USA.|Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA.|Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Katharine
authors.initials: K
authors.lastname: Correia
authors.affiliation: Harvard Medical School, Boston, MA, USA.|Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA.|Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.|Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Stacey A
authors.initials: SA
authors.lastname: Missmer
authors.affiliation: Harvard Medical School, Boston, MA, USA.|Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Yetunde
authors.initials: Y
authors.lastname: Ibrahim
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA.|Division of Reproductive Endocrinology and Infertility, Beth Israel Deaconess Medical Center and Boston IVF, Boston, MA, USA.
authors.forename: Alan S
authors.initials: AS
authors.lastname: Penzias
authors.affiliation: Harvard Medical School, Boston, MA, USA.|Gastroenterology Division, Brigham and Women's Hospital, Boston, AM, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Burakoff
authors.affiliation: Harvard Medical School, Boston, MA, USA.|Gastroenterology Division, Brigham and Women's Hospital, Boston, AM, USA.
authors.forename: Sonia
authors.initials: S
authors.lastname: Friedman
authors.affiliation: Harvard Medical School, Boston, MA, USA. acheifet@bidmc.harvard.edu.|Center for Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center, Boston, MA, USA. acheifet@bidmc.harvard.edu.
authors.forename: Adam S
authors.identifier: http://orcid.org/0000-0002-6010-1896
authors.initials: AS
authors.lastname: Cheifetz
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D003424:Crohn Disease / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007246:Infertility / Q000628:therapy; D007247:Infertility, Female / Q000097:blood / Q000150:complications / Q000628:therapy*; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000628:therapy; D050498:Live Birth; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005640:Follicle Stimulating Hormone
keywords: Crohn’s disease; In vitro fertilization; Infertility; Outcomes; Ulcerative colitis