title: Factors Predicting Subsequent Hospitalization in Patients with Ulcerative Colitis: Total Colonoscopic Findings are the Strongest Predictor.
abstract: OBJECTIVE
  Patients with ulcerative colitis suffer from long term impairment of quality of life, especially when subjected to repeated hospitalization. We aimed to identify factors that may predict future hospitalization.
  
  
  METHODS
  We followed 139 consecutive patients with ulcerative colitis for average of 11.2 years (2.8 to 49.5 years) from the onset. Clinical and endoscopic stagings were determined by Japanese staging system, the extent of colitis by Montreal classification and endoscopic grading by Matts' grade.
  
  
  RESULTS
  Overall hospitalization rate was 37% at 5 years, 47% at 10 years and 60% at 20 years from the onset. Of 5 parameters including demographic and staging scores, univariate analysis revealed clinical severity at onset (p = 0.003), total colonoscopic findings on severity (Matts' grade, p = 0.003), and total colonoscopic findings on sites of abnormality (p = 0.012) were significantly correlated with hospitalization. By multivariate analysis, total colonoscopic findings on sites of abnormality was the only baseline character significantly related to the need of hospitalization (p = 0.0007). In fact, 5/10/20 years hospitalization rates were only 18/26/33 percent for proctitis type, whereas those were 61/72/90 for total colitis type.
  
  
  CONCLUSIONS
  The total colonoscopic finding on sites of abnormality at the onset is the only predictdr of hospitalization in patients with ulcerative colitis.
authors.forename: Toru
authors.initials: T
authors.lastname: Kuno
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kojima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Mochizuki
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Fukasawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawakami
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Iwamoto
authors.forename: Sumio
authors.initials: S
authors.lastname: Hirose
authors.forename: Yuya
authors.initials: Y
authors.lastname: Tsukui
authors.forename: Kenji
authors.initials: K
authors.lastname: Hosoda
authors.forename: Yoji
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hirose
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohtsuka
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Enomoto
authors.forename: Masao
authors.initials: M
authors.lastname: Omata
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult