title: [Establishment of transbronchoscope whole lung lavage and its comparison with bronchoalveolar lavage and whole lung lavage].
abstract: OBJECTIVE
  To establish the technical specifications of transbronchoscope whole lung lavage (TBWLL) and to compare the clinical efficacy between TBWLL and bronchoalveolar lavage (BAL) or whole lung lavage (WLL).
  
  
  METHODS
  A total of 133 patients with pneumoconiosis admitted to Hunan Prevention and Treatment Institute for Occupational Diseases from 2009 to 2014 were divided into TBWLL group (n=43), BAL group (n=45), and WLL group (n=45). Patients in the TBWLL group received conventional BAL of both lungs under a fiber bronchoscope, as well as sedation and anesthesia; lavage was performed twice in each course. TBWLL was compared with the BAL and WLL in terms of lavage volume. The clinical symptoms, pulmonary function, and blood gas before and after treatment and the safety were evaluated.
  
  
  RESULTS
  The TBWLL group had significantly relieved cough and limitation of activity after lavage (P<0.05). Compared with the BAL group, the TBWLL group had significantly increased single lavage volumes and total lavage volume and a significantly shortened length of hospital stay (P<0.05). The three groups showed no significant short-term changes in clinical symptoms and pulmonary function after lavage. The TBWLL and WLL groups had a significantly lower incidence of postoperative complications than the BAL group (P<0.05).
  
  
  CONCLUSIONS
  TBWLL has good clinical efficacy, with the advantages of BAL and WLL, and is highly feasible, safe, and effective.
authors.affiliation: Hunan Provincial Institute for Labor Hygiene and Occupational Diseases, Changsha 410007, China.
authors.forename: Xiongbin
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Hunan Provincial Institute for Labor Hygiene and Occupational Diseases, Changsha 410007, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Hunan Provincial Institute for Labor Hygiene and Occupational Diseases, Changsha 410007, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Hunan Provincial Institute for Labor Hygiene and Occupational Diseases, Changsha 410007, China.
authors.forename: Weirong
authors.initials: W
authors.lastname: Dai
authors.affiliation: Hunan Provincial Institute for Labor Hygiene and Occupational Diseases, Changsha 410007, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Hunan Provincial Institute for Labor Hygiene and Occupational Diseases, Changsha 410007, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.affiliation: Hunan Provincial Institute for Labor Hygiene and Occupational Diseases, Changsha 410007, China.
authors.forename: Meian
authors.initials: M
authors.lastname: Tang
authors.affiliation: Hunan Provincial Institute for Labor Hygiene and Occupational Diseases, Changsha 410007, China; E-mail: TangXiLiang1962@163.com.
authors.forename: Xiliang
authors.initials: X
authors.lastname: Tang
mesh_terms: D018893:Bronchoalveolar Lavage; D020680:Bronchoscopes; D006801:Humans; D008168:Lung / Q000503:physiopathology; D011009:Pneumoconiosis / Q000628:therapy*; D007507:Therapeutic Irrigation / Q000379:methods*