title: Serum Calcium Concentration Is Inversely Associated With Radiographic Knee Osteoarthritis: A Cross-Sectional Study.
abstract: To examine the relationship between serum calcium (Ca) concentration and radiographic knee osteoarthritis (OA).This study covered a total of 2855 subjects. The serum Ca concentration was detected by the Arsenazo III method. The radiographic OA of the knee was defined as changes equivalent to Kellgren-Lawrence grade 2 on 1 side at least. The serum Ca concentration was categorized into 4 quartiles, which are ≤2.27, 2.28-2.34, 2.35-2.41, and ≥2.42 mmol/L, respectively. The relationship between serum Ca and radiographic knee OA was examined using the multivariable logistic analysis after adjusting a series of potential confounding factors. For each quartile of the relationship between serum Ca concentration and radiographic knee OA, the OR with 95% CI was calculated, and the one with the lowest value was considered to be the reference.An inverse association existed between serum Ca concentration and radiographic OA of the knee in the multivariable model and the model where the factors of age, sex, and BMI were adjusted. The multivariable-adjusted OR (95% CI) for radiographic knee OA in the second, third, and fourth quartiles of serum Ca concentration were 1.05 (95% CI: 0.83-1.31), 1.01 (95% CI: 0.80-1.27), and 0.79 (95% CI: 0.62-1.00), respectively, in comparison with the reference (first) quartile. A trend approaching to statistical significant (P = 0.06) was observed. Meanwhile, the relative odds of radiographic OA of the knee were decreased by 0.79 times in the fourth quartile in comparison with the reference.There is likely to be an inverse association between serum Ca concentration and radiographic OA of the knee.
authors.affiliation: From the Department of Orthopaedics (HL, CZ, TY, S-GG, Y-SL, WL, W-FX, Y-LX, G-HL); Health Management Center (JW), Xiangya Hospital; and Department of Epidemiology and Health Statistics (JW), School of Public Health, Central South University, Changsha, Hunan Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Zeng
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.forename: Tuo
authors.initials: T
authors.lastname: Yang
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Gao
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Luo
authors.forename: Wen-Feng
authors.initials: WF
authors.lastname: Xiao
authors.forename: Yi-Lin
authors.initials: YL
authors.lastname: Xiong
authors.forename: Guang-Hua
authors.initials: GH
authors.lastname: Lei
mesh_terms: D002118:Calcium / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000000981:diagnostic imaging*; D011859:Radiography
chemical_list: D002118:Calcium