title: Anthocyanins in Strawberry Polyphenolic Extract Enhance the Beneficial Effects of Diets with Fructooligosaccharides in the Rat Cecal Environment.
abstract: The administration of fructooligosaccharides (FOS) beneficially modulates gastrointestinal functions and may enhance the metabolism of polyphenols. However, different polyphenolic components in the diet may have different influences on the activities of the digestive enzymes and microbiota in the gastrointestinal tract. Therefore, a 4-week study of forty-eight male Wistar rats was conducted to investigate the physiological response of the rat cecal environment to diets without and with FOS that contained two different strawberry polyphenolic extracts, specifically EP (polyphenolic profile 60, 35, 5, and 0% ellagitannins, proanthocyanidins, flavonols, anthocyanins, respectively) and EPA (polyphenolic profile: 50, 35, 6, and 9%, respectively). When combined with FOS, both extracts beneficially enhanced the acidification of the cecal digesta (P≤0.05 vs the groups without extracts), but the dietary combination of EPA and FOS elicited the greatest reduction in putrefactive short-chain fatty acid production and the lowest fecal β-glucuronidase activity in the cecum (P≤0.05 vs group EP). Moreover, the addition of dietary FOS elevated the metabolism of the examined strawberry extracts in the cecum and thereby increased the concentrations of the metabolites in the cecal digesta and urine (P≤0.05 vs the group with cellulose). Overall, both strawberry extracts modulated the effects of FOS in the gastrointestinal tract; however, the combination with EPA extract that contained anthocyanins exhibited greater beneficial effects in the lower gut environment than the EP extract.
authors.affiliation: Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Fotschki
authors.affiliation: Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Juśkiewicz
authors.affiliation: Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Jurgoński
authors.affiliation: Institute of Food Technology and Analysis, Łódź University of Technology, Łódź, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kołodziejczyk
authors.affiliation: Institute of Food Technology and Analysis, Łódź University of Technology, Łódź, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Milala
authors.affiliation: Institute of Food Technology and Analysis, Łódź University of Technology, Łódź, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Kosmala
authors.affiliation: Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
authors.forename: Zenon
authors.initials: Z
authors.lastname: Zduńczyk
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000302:isolation & purification / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002432:Cecum / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D004032:Diet / Q000379:methods; D004063:Digestion / Q000187:drug effects / Q000502:physiology; D005232:Fatty Acids, Volatile / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism; D044948:Flavonols / Q000302:isolation & purification / Q000494:pharmacology*; D031985:Fragaria / Q000737:chemistry; D005966:Glucuronidase / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism; D047348:Hydrolyzable Tannins / Q000302:isolation & purification / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D008297:Male; D009844:Oligosaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols / Q000302:isolation & purification / Q000494:pharmacology*; D044945:Proanthocyanidins / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000872:Anthocyanins; D005232:Fatty Acids, Volatile; D044948:Flavonols; D047348:Hydrolyzable Tannins; D009844:Oligosaccharides; D010936:Plant Extracts; D059808:Polyphenols; D044945:Proanthocyanidins; C116580:fructooligosaccharide; D005966:Glucuronidase