title: Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?
abstract: Among the human copper-containing monooxygenases, Tyrosinase (Ty) is an important enzyme involved in the determinant step of the biosynthetic pathway of melanin pigment. In this pathway, Ty catalyzes the tyrosine monooxygenation into L-DOPA-quinone, which is the precursor of the skin pigment melanin. Ty inhibitors/activators are a well-established approach for controlling in vivo melanin production, so their development has a huge economical and industrial impact. Moreover, recent publications highlight that targeting tyrosinase with inhibitors/activators to treat melanogenesis disorders is one of many possible approaches, due to the complex biochemical reaction involved in the melanin synthesis.
authors.forename: Elina
authors.initials: E
authors.lastname: Buitrago
authors.forename: Renaud
authors.initials: R
authors.lastname: Hardré
authors.forename: Romain
authors.initials: R
authors.lastname: Haudecoeur
authors.forename: Hélène
authors.initials: H
authors.lastname: Jamet
authors.forename: Catherine
authors.initials: C
authors.lastname: Belle
authors.forename: Ahcène
authors.initials: A
authors.lastname: Boumendjel
authors.forename: Luigi
authors.initials: L
authors.lastname: Bubacco
authors.affiliation: ISM2 UMR CNRS 7313, Centre Scientifique de Saint Jérôme, Aix Marseille Université, 13397, Marseille cedex 20, France. marius.reglier@univ-amu.fr.
authors.forename: Marius
authors.initials: M
authors.lastname: Réglier
mesh_terms: D000595:Amino Acid Sequence; D055162:Biocatalysis; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D008958:Models, Molecular; D014442:Monophenol Monooxygenase / Q000737:chemistry / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000737:chemistry / Q000187:drug effects; D017386:Sequence Homology, Amino Acid
chemical_list: D009363:Neoplasm Proteins; D014442:Monophenol Monooxygenase