title: Intersubunit Bridges of the Bacterial Ribosome.
abstract: The ribosome is a large two-subunit ribonucleoprotein machine that translates the genetic code in all cells, synthesizing proteins according to the sequence of the mRNA template. During translation, the primary substrates, transfer RNAs, pass through binding sites formed between the two subunits. Multiple interactions between the ribosomal subunits, termed intersubunit bridges, keep the ribosome intact and at the same time govern dynamics that facilitate the various steps of translation such as transfer RNA-mRNA movement. Here, we review the molecular nature of these intersubunit bridges, how they change conformation during translation, and their functional roles in the process.
authors.affiliation: Ohio State Biochemistry Program, Department of Microbiology, and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Ohio State Biochemistry Program, Department of Microbiology, and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA. Electronic address: fredrick.5@osu.edu.
authors.forename: Kurt
authors.initials: K
authors.lastname: Fredrick
mesh_terms: D014176:Protein Biosynthesis / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics / Q000378:metabolism; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D012333:RNA, Messenger; D012343:RNA, Transfer
keywords: protein synthesis; rRNA; tRNA; translation