title: [A case-control study of correlation between serum adiponectin levels and polycystic ovary syndrome].
abstract: OBJECTIVE
  To compare the difference of serum adiponectin levels between polycystic ovary syndrome (PCOS) patients and age, boby mass index (BMI) and insulin-resistance index matched controls, and explore its influence factors.
  
  
  METHODS
  Case-control study, involving 97 women with PCOS and 116 age, BMI, fasting plasma glucose and insulin levels, homeostasis model assessment-insulin resistance index (HOMA-IR) matched controls. Hormone profiles, and serum adiponectin levels were measured and compared. Hormone profiles and serum adiponectin levels were compared among the four PCOS phenotypes. Multiple regression analysis was used to evaluate the factors affecting serum adiponectin levels.
  
  
  RESULTS
  (1) Serum adiponectin level was significantly lower in PCOS group [(21±16) mg/L] than controls [(25±13) mg/L, P=0.038], and the same result in stratified analysis on weight height ratio (WHR, ≥0.8 and <0.8). (2) There was statistical differences in testosterone among different four PCOS phenotypes (P=0.001), there were no statistical differences in FSH, LH, WHR and serum adiponectin levels among four PCOS phenotypes (P>0.05). (3) WHR and PCOS status were independent determinants of serum adiponectin levels (P<0.05).
  
  
  CONCLUSIONS
  Low serum adiponectin levels in the women with PCOS is correlated with PCOS per se, independent of insulin resistance and obese. This fact supports the further study of the effect of adiponection in the pathophysiology of PCOS and its log-term impact.
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.
authors.forename: Yaxiao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.
authors.forename: Xiaomiao
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China; Email: yangdz@mail.sysu.edu.cn.
authors.forename: Dongzi
authors.initials: D
authors.lastname: Yang
mesh_terms: D052242:Adiponectin / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007328:Insulin; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000503:physiopathology*; D012044:Regression Analysis; D013739:Testosterone / Q000097:blood
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone