title: STK38 at the crossroad between autophagy and apoptosis.
abstract: We describe the STK38 protein kinase as a conserved regulator of autophagy. We discovered STK38 as a novel binding partner of Beclin1, a key regulator of autophagy. By combining molecular, cell biological and genetic approaches, we show that STK38 promotes autophagosome formation in human cells and in Drosophila. Furthermore, we also provide evidence demonstrating that STK38 with the small GTPase RalB, assist the co-ordination between autophagic and apoptotic events upon autophagy induction, hence proposing a role for STK38 in determining cellular fate in response to autophagic conditions.
authors.affiliation: a Cancer Research Center of Toulouse , UMR1037 , Toulouse , France.
authors.forename: Carine
authors.initials: C
authors.lastname: Joffre
authors.affiliation: b INSERM U1151-CNRS UMR 8253, Institut Necker Enfants-Malades , Paris , France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Codogno
authors.affiliation: c Department of Basic and Clinical Neuroscience , Kings College London , London , UK.
authors.forename: Manolis
authors.initials: M
authors.lastname: Fanto
authors.affiliation: d University College London, Cancer Institute , London , UK.
authors.forename: Alexander
authors.initials: A
authors.lastname: Hergovich
authors.affiliation: e INSERM U830, Institut Curie , Paris , France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Camonis
mesh_terms: D000818:Animals; D017209:Apoptosis; D000071182:Autophagosomes / Q000378:metabolism; D001343:Autophagy; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D017346:Protein Serine-Threonine Kinases
keywords: Beclin1; Hippo pathway; NDR protein kinase; apoptosis; autophagy