title: Acute Exacerbation of Idiopathic Pulmonary Fibrosis Following Treatment for Cushing's Syndrome.
abstract: A 64-year-old Japanese man with mild reticular shadows in both lungs developed a lung tumor causing ectopic Cushing's syndrome. He was prescribed an adrenal inhibitor, which controlled his hypercortisolemia. However, he developed acute exacerbation of idiopathic pulmonary fibrosis (IPF) and died within weeks. Previous studies have suggested a dosage reduction of corticosteroids for IPF as a triggering event for acute exacerbation. The present case suggests that IPF coexisting with Cushing's syndrome may have been exacerbated after the correction of hypercortisolemia. Therefore, close monitoring of cortisol levels along with the clinical course of IPF is required in similar cases that require the correction of hypercortisolemia.
authors.affiliation: Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Japan.
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Ohara
authors.forename: Masanori
authors.initials: M
authors.lastname: Kaneko
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Usuda
authors.forename: Junta
authors.initials: J
authors.lastname: Tanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Maekawa
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
authors.forename: Hideki
authors.initials: H
authors.lastname: Katakami
authors.forename: Kenzo
authors.initials: K
authors.lastname: Kaneko
authors.forename: Kyuzi
authors.initials: K
authors.lastname: Kamoi
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D001344:Autopsy; D003480:Cushing Syndrome / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
chemical_list: D000324:Adrenocorticotropic Hormone