title: Pelvic organ prolapse repair using the Uphold™ Vaginal Support System: a 1-year multicenter study.
abstract: OBJECTIVE
  The objective was to assess safety and clinical outcomes in women operated on using the Uphold™ Lite Vaginal Support System.
  
  
  METHODS
  We carried out a 1-year, multicenter, prospective, single cohort study of 207 women with symptomatic Pelvic Organ Prolapse Quantification (POP-Q) stage ≥2 apical pelvic organ prolapse, with or without concomitant anterior vaginal wall prolapse. Safety data were collected using a standardized questionnaire. Anatomical outcome was assessed by the POP-Q and subjective outcomes by the Pelvic Floor Distress Inventory after 2 months and 1 year using a one-way repeated measures analysis of variance. Pain was evaluated using a visual analog scale.
  
  
  RESULTS
  The overall rate of serious complications was 4.3 % (9 out of 207 patients), including 3 patients with bladder perforations, 1 with bleeding >1,000 ml, 2 who had undergone re-operations with complete mesh removal because of pain, and 3 surgical interventions during follow-up because of mesh exposure. POP-Q stage ≤1 after 1 year was 94 % and subjective symptom relief was reported by 91 % of patients (p < 0.001). Pain after 2 months and 1 year was 60 % lower compared with the preoperative mean (p < 0.001). Minor complications occurred in 20 women (9.7 %) and were dominated by lower urinary tract dysfunction. No predisposing risk factors for complications were found.
  
  
  CONCLUSIONS
  The Uphold™ Lite procedure in women with apical pelvic organ prolapse provided satisfactory restoration of vaginal topography and symptom relief. However, serious complication rates were largely comparable with those of other transvaginal mesh kits.
authors.affiliation: Stockholm Urogynecological Clinic, Kommendörsgatan 5, 114 48, Stockholm, Sweden. daniel.altman@ki.se.|Department of Obstetrics and Gynecology, Danderyd Hospital, Danderyd, Sweden. daniel.altman@ki.se.
authors.forename: Daniel
authors.initials: D
authors.lastname: Altman
authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.|Folkhälsan Research center, Helsinki, Finland.
authors.forename: Tomi S
authors.initials: TS
authors.lastname: Mikkola
authors.affiliation: Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Karl Möller
authors.initials: KM
authors.lastname: Bek
authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Päivi
authors.initials: P
authors.lastname: Rahkola-Soisalo
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Göteborg, Sweden.
authors.forename: Jonas
authors.initials: J
authors.lastname: Gunnarsson
authors.affiliation: Department of Obstetrics and Gynaecology, Akershus University Hospital, Lørenskog, Norway.
authors.forename: Marie Ellström
authors.initials: ME
authors.lastname: Engh
authors.affiliation: Department of Obstetrics and Gynecology, Danderyd Hospital, Danderyd, Sweden.
authors.forename: Christian
authors.initials: C
authors.lastname: Falconer
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D017773:Pelvic Floor / Q000601:surgery; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D011446:Prospective Studies; D019919:Prosthesis Implantation / Q000379:methods*; D053825:Suburethral Slings / Q000009:adverse effects*; D013526:Surgical Mesh / Q000009:adverse effects*; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014621:Vagina / Q000601:surgery
keywords: Complications; Mesh; Pelvic organ prolapse