title: Clinical significance of serum protease activated receptor1 levels in patients with lung cancer.
abstract: OBJECTIVE
  Protease-activated receptors (PAR) are G protein coupled receptors and they regulate many biological processes, including coagulation and cell survival and they might be good markers in some types of malignant tumors, providing useful information in diagnosis and prognosis. The objective of this study was to determine the clinical significance of the serum levels of PAR1 in lung cancer patients.
  
  
  METHODS
  Eighty patients with lung cancer were enrolled into this study. Serum PAR1 levels were determined by the solid-phase sandwich ELISA method. Median age was 58.5-years old, range 36 to 80 years.
  
  
  RESULTS
  The majority of the patients had NSCLC (85%) and stage IV disease (56%). The baseline serum PAR1 concentrations of the lung cancer patients were significantly higher than control group (median values 26.45 ng/mL v 0.07 ng/mL, p < 0.001). However, clinical variables including age, gender, histology, stage of disease, and response to chemotherapy were not found to be correlated with serum PAR1 levels (p > 0.05). Moreover, it failed to show any prognostic value on the survival of the lung cancer patients.
  
  
  CONCLUSIONS
  The serum levels of PAR1 might have a diagnostic value in lung cancer patients. However, its predictive and prognostic values were not determined.
authors.affiliation: Institute of Oncology, University of Istanbul, Istanbul, Turkey. kayhanerturk@gmail.com.
authors.forename: K
authors.initials: K
authors.lastname: Erturk
authors.forename: D
authors.initials: D
authors.lastname: Tastekin
authors.forename: E
authors.initials: E
authors.lastname: Bilgin
authors.forename: F
authors.initials: F
authors.lastname: Tas
authors.forename: R
authors.initials: R
authors.lastname: Disci
authors.forename: D
authors.initials: D
authors.lastname: Duranyildiz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000175:diagnosis; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D044463:Receptor, PAR-1 / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D044463:Receptor, PAR-1