title: Energy sensing and cancer: LKB1 function and lessons learnt from Peutz-Jeghers syndrome.
abstract: We describe in this review increasing evidence that loss of LKB1 kinase in Peutz-Jeghers syndrome (PJS) derails the existing natural balance between cell survival and tumour growth suppression. LKB1 deletion can plunge cells into an energy/oxidative stress-induced crisis which leads to the activation of alternative and often carcinogenic pathways to maintain cellular energy levels. It therefore appears that although LKB1 deficiency can suppress oncogenic transformation in the short term, it can ultimately lead to more progressed and malignant phenotypes by driving abnormal cell differentiation, genomic instability and increased tumour heterogeneity.
authors.affiliation: European Cancer Stem Cell Research Institute, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, United Kingdom. Electronic address: ShorningB@cf.ac.uk.
authors.forename: Boris Y
authors.initials: BY
authors.lastname: Shorning
authors.affiliation: European Cancer Stem Cell Research Institute, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, United Kingdom.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Clarke
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D000818:Animals; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D010580:Peutz-Jeghers Syndrome / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism
chemical_list: D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases
keywords: LKB1 kinase; Metabolism; Peutz–Jeghers syndrome; Tumourigenesis