title: ILC You Later: Early and Irreparable Loss of Innate Lymphocytes in HIV Infection.
abstract: Loss of IL-17-producing cells in the gut during HIV infection is linked to GI barrier damage. Kløverpris et al. (2016) find that circulating ILCs are lost early and irreversibly during HIV infection. Early ART administration protects against the ILC loss, and this might be clinically beneficial to HIV-infected individuals.
authors.affiliation: Immunopathogenesis Section, Lab of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20874, USA.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Mudd
authors.affiliation: Immunopathogenesis Section, Lab of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20874, USA. Electronic address: jbrenchl@niaid.nih.gov.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Brenchley
mesh_terms: D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D007422:Intestines / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology*
chemical_list: D007371:Interferon-gamma