title: Oxidation of cholesterol and O-protected derivatives by the environmental pollutant NO₂.
abstract: Exposure of O-protected and free cholesterol to NO2˙ under exclusion of water leads to nitroimine nitrates through a non-radical mechanism, which reveals the high susceptibility of the π system to oxidative damage. In the presence of moisture the reaction leads to 6-nitrocholesterols , which result from hydrolysis and oxidation of 2.
authors.affiliation: School of Chemistry, Bio21 Institute, The University of Melbourne, Parkville, Victoria 3010, Australia. uwille@unimelb.edu.au.
authors.forename: A N
authors.initials: AN
authors.lastname: Zalewski
authors.affiliation: School of Chemistry, Bio21 Institute, The University of Melbourne, Parkville, Victoria 3010, Australia. uwille@unimelb.edu.au.
authors.forename: J G
authors.initials: JG
authors.lastname: Nathanael
authors.affiliation: School of Chemistry, Bio21 Institute, The University of Melbourne, Parkville, Victoria 3010, Australia. uwille@unimelb.edu.au.
authors.forename: J M
authors.initials: JM
authors.lastname: White
authors.affiliation: School of Chemistry, Bio21 Institute, The University of Melbourne, Parkville, Victoria 3010, Australia. uwille@unimelb.edu.au.
authors.forename: U
authors.initials: U
authors.lastname: Wille
mesh_terms: D002784:Cholesterol / Q000031:analogs & derivatives / Q000737:chemistry*; D004785:Environmental Pollutants / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry*; D009566:Nitrates / Q000737:chemistry*; D009585:Nitrogen Dioxide / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D004785:Environmental Pollutants; D005609:Free Radicals; D009566:Nitrates; D016877:Oxidants; C056245:6-nitrocholesterol; D002784:Cholesterol; D009585:Nitrogen Dioxide