title: Increased risk of hepatic complications in kidney transplantation with chronic virus hepatitis infection: A nationwide population-based cohort study.
abstract: Data regarding the risk of various liver diseases among different hepatitis viruses in kidney transplantation have not yet been identified.We selected individuals with kidney transplantation (ICD-9-CM V420 or 996.81) from 2000-2009 from the catastrophic illness registry of National Health Insurance Research Database (NHIRD)as the study cohort. The two end-points in the study included overall death, and post-transplant occurrence of hepatic disease. After adjustment for other risk factors, the risk of mortality was increased in patients with HBV infection (N = 352) and with HCV infection (N = 275) compared to those with neither HBV nor HCV infection (N = 3485). In addition,renal transplant recipients with HBV alone,HCV alone, and both with HBV and HCVinfectionrespectively had an approximately 10-fold hazard ratio (HR) = 9.84, 95% confidence interval (CI): 4.61-21.0, 4-fold increased risk (HR = 4.40, 95% CI: 1.85-10.5)and 5-fold increased risk (HR = 4.63, 95% CI: 1.06-20.2)of hepatocellular carcinoma (HCC)compared to those with neither HBV nor HCV infection. Our findings showed a significant risk of de novo liver disease in recipients with hepatitis virus infection. Based on our findings, we reinforce the importance and impact of hepatitis virus in renal transplantation.
authors.affiliation: Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.|Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Tung-Min
authors.initials: TM
authors.lastname: Yu
authors.affiliation: Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.|Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Che-Chen
authors.initials: CC
authors.lastname: Lin
authors.affiliation: Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Shu
authors.affiliation: Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Chuang
authors.affiliation: Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Shih-Ting
authors.initials: ST
authors.lastname: Huang
authors.affiliation: Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Cheng-Hsu
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Ming-Ju
authors.initials: MJ
authors.lastname: Wu
authors.affiliation: Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Mu-Chi
authors.initials: MC
authors.lastname: Chung
authors.affiliation: Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.|Department of Urology, China Medical University and Hospital, Taichung, Taiwan.
authors.forename: Chao-Hsiang
authors.initials: CH
authors.lastname: Chang
authors.affiliation: Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.|Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Chi-Yuan
authors.initials: CY
authors.lastname: Li
authors.affiliation: Department of Health Risk Management, College of Public Health, China Medical University, Taichung, Taiwan.|Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Chi-Jung
authors.initials: CJ
authors.lastname: Chung
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006521:Hepatitis, Chronic / Q000453:epidemiology* / Q000209:etiology*; D006525:Hepatitis, Viral, Human / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents