title: Prostate Cancer Imaging with Novel PET Tracers.
abstract: Molecular imaging of prostate cancer is in a dynamic phase of development. Currently approved techniques are limited and researchers have been working on novel agents to improve accuracy in targeting and detecting prostate tumors. In addition, the complexity of various prostate cancer states also contributes to the challenges in evaluating suitable radiotracer candidates. We have highlighted nuclear medicine tracers that focus on mechanisms involved in bone metastasis, prostate cancer cell membrane synthesis, amino acid analogs, androgen analogs, and the prostate specific membrane antigen. Encouraging results with many of these innovative radiotracer compounds will not only advance diagnostic capabilities for prostate cancer but open opportunities for theranostic applications to treat this worldwide malignancy.
authors.affiliation: Center for Cancer Research, National Cancer Institute, BG 10-CRC RM 3-2571 MSC 1206, 10 Center Dr, Bethesda, MD, 20892-1206, USA. liza.lindenberg@mail.nih.gov.|Molecular Imaging Program, National Cancer Institute, BG 10 RM B3B69F MS 1002, 10 Center Dr, Bethesda, MD, 20814, USA. liza.lindenberg@mail.nih.gov.
authors.forename: Liza
authors.initials: L
authors.lastname: Lindenberg
authors.affiliation: Center for Cancer Research, National Cancer Institute, BG 10-CRC RM 3-2571 MSC 1206, 10 Center Dr, Bethesda, MD, 20892-1206, USA. pchoyke@mail.nih.gov.|Molecular Imaging Program, National Cancer Institute, BG 10 RM B3B69F MS 1002, 10 Center Dr, Bethesda, MD, 20814, USA. pchoyke@mail.nih.gov.
authors.forename: Peter
authors.initials: P
authors.lastname: Choyke
authors.affiliation: Center for Cancer Research, National Cancer Institute, BG 10-CRC RM 3-2571 MSC 1206, 10 Center Dr, Bethesda, MD, 20892-1206, USA. dahutw@mail.nih.gov.|Genitourinary Malignancies Branch, National Cancer Institute, BG 10 RM B3B402 MS 1088, 10 CENTER DR, Bethesda, MD, 20814, USA. dahutw@mail.nih.gov.
authors.forename: William
authors.initials: W
authors.lastname: Dahut
mesh_terms: D000954:Antigens, Surface / Q000378:metabolism; D043425:Glutamate Carboxypeptidase II / Q000378:metabolism; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000201:enzymology; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D000954:Antigens, Surface; D019275:Radiopharmaceuticals; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II
keywords: 11C acetate; 11C/18F choline; 18F DCFBC; 18F DHT; 18F FACBC; 18F NaF; 68Ga PSMA