title: Neuromagnetic correlates of adaptive plasticity across the hand-face border in human primary somatosensory cortex.
abstract: It is well established that permanent or transient reduction of somatosensory inputs, following hand deafferentation or anesthesia, induces plastic changes across the hand-face border, supposedly responsible for some altered perceptual phenomena such as tactile sensations being referred from the face to the phantom hand. It is also known that transient increase of hand somatosensory inputs, via repetitive somatosensory stimulation (RSS) at a fingertip, induces local somatosensory discriminative improvement accompanied by cortical representational changes in the primary somatosensory cortex (SI). We recently demonstrated that RSS at the tip of the right index finger induces similar training-independent perceptual learning across the hand-face border, improving somatosensory perception at the lips (Muret D, Dinse HR, Macchione S, Urquizar C, Farnè A, Reilly KT.Curr Biol24: R736-R737, 2014). Whether neural plastic changes across the hand-face border accompany such remote and adaptive perceptual plasticity remains unknown. Here we used magnetoencephalography to investigate the electrophysiological correlates underlying RSS-induced behavioral changes across the hand-face border. The results highlight significant changes in dipole location after RSS both for the stimulated finger and for the lips. These findings reveal plastic changes that cross the hand-face border after an increase, instead of a decrease, in somatosensory inputs.
authors.affiliation: ImpAct Team, Lyon Neuroscience Research Centre, INSERM U1028, CNRS UMR5292, Lyon, France; University Claude Bernard Lyon I, Lyon, France; dollyane.muret@gmail.com.
authors.forename: Dollyane
authors.initials: D
authors.lastname: Muret
authors.affiliation: CERMEP, MEG Department, Bron, France;
authors.forename: Sébastien
authors.initials: S
authors.lastname: Daligault
authors.affiliation: Neural Plasticity Laboratory, Institute of Neuroinformatics, Ruhr University, Bochum, Germany; Clinic of Neurology, BG University Hospital Bergmannsheil, Bochum, Germany; and.
authors.forename: Hubert R
authors.initials: HR
authors.lastname: Dinse
authors.affiliation: CERMEP, MEG Department, Bron, France;
authors.forename: Claude
authors.initials: C
authors.lastname: Delpuech
authors.affiliation: University Claude Bernard Lyon I, Lyon, France; Dycog Team, Lyon Neuroscience Research Centre, INSERM U1028, CNRS UMR5292, Lyon, France.
authors.forename: Jérémie
authors.initials: J
authors.lastname: Mattout
authors.affiliation: ImpAct Team, Lyon Neuroscience Research Centre, INSERM U1028, CNRS UMR5292, Lyon, France; University Claude Bernard Lyon I, Lyon, France;
authors.forename: Karen T
authors.initials: KT
authors.lastname: Reilly
authors.affiliation: ImpAct Team, Lyon Neuroscience Research Centre, INSERM U1028, CNRS UMR5292, Lyon, France; University Claude Bernard Lyon I, Lyon, France;
authors.forename: Alessandro
authors.initials: A
authors.lastname: Farnè
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D005073:Evoked Potentials, Somatosensory; D005145:Face / Q000294:innervation*; D005260:Female; D006225:Hand / Q000294:innervation*; D006801:Humans; D007858:Learning; D015225:Magnetoencephalography; D008297:Male; D009473:Neuronal Plasticity; D011597:Psychomotor Performance; D013003:Somatosensory Cortex / Q000502:physiology*
keywords: MEG; cortical plasticity; dipole; learning; somatosensory input; spatial discrimination