title: Effects of topical corticosteroid administration on intraocular pressure in normal and glaucomatous cats.
abstract: OBJECTIVE
  The objective of this study was to determine the effect of topical corticosteroid (CCS) therapy on intraocular pressure (IOP) in normal cats and cats with primary feline congenital glaucoma (FCG).
  
  
  METHODS
  Five normal and 11 FCG cats were studied in two cohorts.
  
  
  METHODS
  IOP was measured by a single, masked observer, once daily, 3-5 days/week throughout the course of CCS treatment and for up to 11 days after treatment discontinuation. One eye per cat was randomly assigned for treatment twice daily with CCS; balanced salt solution (BSS) applied to the contralateral eye served as a control. Differences between eyes and between weeks of the study period were calculated for each cat. A positive response to CCS was defined as a consistent >15% or >25% higher IOP in the treated relative to control eye in normal and FCG cats, respectively.
  
  
  RESULTS
  A total of 8 of 11 FCG cats responded to topical CCS after 1-5 weeks of treatment with an increase in IOP relative to the untreated eye (maximum IOP discrepancy of 56 mmHg). Two of five normal cats responded to topical CCS with an appreciable, but clinically unimportant increase in IOP in the treated eye (maximum IOP discrepancy of 6.4 mmHg).
  
  
  CONCLUSIONS
  Our data indicate that the incidence of steroid-induced IOP elevation in cats is lower than that of previously published feline studies. Cats with preexisting compromise in aqueous humor outflow may show a greater, clinically relevant response to topical CCS than normal cats.
authors.affiliation: Department of Surgical Sciences, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: Allyson A
authors.initials: AA
authors.lastname: Gosling
authors.affiliation: Department of Ophthalmology & Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Kiland
authors.affiliation: Department of Ophthalmology & Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Rutkowski
authors.affiliation: Department of Ophthalmology & Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Hoefs
authors.affiliation: Department of Animal Science, Iowa State University, Ames, IA, USA.
authors.forename: Norman Matthew
authors.initials: NM
authors.lastname: Ellinwood
authors.affiliation: Department of Surgical Sciences, University of Wisconsin-Madison, Madison, WI, USA.|Department of Ophthalmology & Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.|McPherson Eye Research Institute, Madison, WI, USA.
authors.forename: Gillian J
authors.initials: GJ
authors.lastname: McLellan
mesh_terms: D060433:Administration, Ophthalmic; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D015331:Cohort Studies; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005901:Glaucoma / Q000188:drug therapy / Q000662:veterinary*; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D009883:Ophthalmic Solutions; D003907:Dexamethasone; D011239:Prednisolone
keywords: cat; corticosteroid; glaucoma; intraocular pressure; steroid-induced ocular hypertension