title: Mild Cobalt-Catalyzed Negishi Cross-Couplings of (Hetero)arylzinc Reagents with (Hetero)aryl Halides.
abstract: A catalytic system consisting of CoCl2 ⋅2 LiCl (5 mol %) and HCO2 Na (50 mol %) enables the cross-coupling of various N-heterocyclic chlorides and bromides as well as aromatic halogenated ketones with various electron-rich and -poor arylzinc reagents. The reactions reached full conversion within a few hours at 25 °C.
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, Munich, Germany.
authors.forename: Diana
authors.initials: D
authors.lastname: Haas
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, Munich, Germany.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Hammann
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, Munich, Germany.
authors.forename: Ferdinand H
authors.initials: FH
authors.lastname: Lutter
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, Munich, Germany. paul.knochel@cup.uni-muenchen.de.
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
keywords: Negishi coupling; cobalt; cross-coupling; heteroarenes; heterocycles