title: Novel targets for mitochondrial medicine.
abstract: Mitochondria-classically viewed as the powerhouses of the cell-have taken center stage in disease pathogenesis and resolution. Mitochondrial dysfunction, which originates from primary defects within the organelle or is induced by environmental stresses, plays a critical role in human disease. Despite their central role in human health and disease, there are no approved drugs that directly target mitochondria. We present possible new druggable targets in mitochondrial biology, including protein modification, calcium ion (Ca(2+)) transport, and dynamics, as we move into a new era of mitochondrial medicine.
authors.affiliation: Mitochondria and Metabolism Center, Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98109, USA. wangwang@uw.edu rongtian@uw.edu.
authors.forename: Wang
authors.initials: W
authors.lastname: Wang
authors.affiliation: Pfizer Global Research and Development CVMED (Cardiovascular and Metabolic Diseases), Cambridge, MA 02139, USA.
authors.forename: Georgios
authors.initials: G
authors.lastname: Karamanlidis
authors.affiliation: Mitochondria and Metabolism Center, Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98109, USA. wangwang@uw.edu rongtian@uw.edu.
authors.forename: Rong
authors.initials: R
authors.lastname: Tian
mesh_terms: D002118:Calcium / Q000378:metabolism; D006801:Humans; D008511:Medicine; D008928:Mitochondria / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D024101:Mitochondrial Proteins / Q000378:metabolism; D058990:Molecular Targeted Therapy
chemical_list: D024101:Mitochondrial Proteins; D002118:Calcium