title: The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity.
abstract: Pathogens attack host cells by deploying toxins that perturb core host processes. Recent findings from the nematode C. elegans and other metazoans indicate that surveillance or "effector-triggered" pathways monitor functioning of these core processes and mount protective responses when they are perturbed. Despite a growing number of examples of surveillance immunity, the signaling components remain poorly defined. Here, we show that CEBP-2, the C. elegans ortholog of mammalian CCAAT-enhancer-binding protein gamma, is a key player in surveillance immunity. We show that CEBP-2 acts together with the bZIP transcription factor ZIP-2 in the protective response to translational block by P. aeruginosa Exotoxin A as well as perturbations of other processes. CEBP-2 serves to limit pathogen burden, promote survival upon P. aeruginosa infection, and also promote survival upon Exotoxin A exposure. These findings may have broad implications for the mechanisms by which animals sense pathogenic attack and mount protective responses.
authors.affiliation: Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
authors.forename: Kirthi C
authors.initials: KC
authors.lastname: Reddy
authors.affiliation: Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
authors.forename: Tiffany L
authors.initials: TL
authors.lastname: Dunbar
authors.affiliation: Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; BCMB Allied Program, Weill Cornell Medical College, New York, NY 10065, USA.
authors.forename: Amrita M
authors.initials: AM
authors.lastname: Nargund
authors.affiliation: Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; BCMB Allied Program, Weill Cornell Medical College, New York, NY 10065, USA.
authors.forename: Cole M
authors.initials: CM
authors.lastname: Haynes
authors.affiliation: Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: etroemel@ucsd.edu.
authors.forename: Emily R
authors.initials: ER
authors.lastname: Troemel
mesh_terms: D036002:ADP Ribose Transferases / Q000096:biosynthesis / Q000276:immunology; D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis / Q000276:immunology; D022762:CCAAT-Enhancer-Binding Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*; D017173:Caenorhabditis elegans / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D029742:Caenorhabditis elegans Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*; D064550:Death-Associated Protein Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*; D005098:Exotoxins / Q000096:biosynthesis / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D007157:Immunologic Surveillance; D011550:Pseudomonas aeruginosa / Q000254:growth & development* / Q000276:immunology; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D015996:Survival Rate; D037521:Virulence Factors / Q000096:biosynthesis / Q000276:immunology; D000097668:Pseudomonas aeruginosa Exotoxin A
chemical_list: D036002:ADP Ribose Transferases; D001427:Bacterial Toxins; D022762:CCAAT-Enhancer-Binding Proteins; D029742:Caenorhabditis elegans Proteins; D064550:Death-Associated Protein Kinases; D005098:Exotoxins; D034741:RNA, Small Interfering; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A; C000605818:CEBP-2 protein, C elegans