title: The association of TGFB1 genetic polymorphisms with high myopia: a systematic review and meta-analysis.
abstract: OBJECTIVE
  The TGFB1 gene is among the most studied genes in high myopia due to its role in scleral remodeling. But reported findings of association on TGFB1 and high myopia are inconsistent. This present study is to evaluate the association of TGFB1 polymorphisms and high myopia.
  
  
  METHODS
  A comprehensive literature search was conducted on studies published up to April 5, 2015. Summary odds ratios (ORs) and 95% confidence intervals were analyzed. Heterogeneity across studies was evaluated by Cochran Q statistic test and the I(2) index. Sensitivity analyses were conducted by the approach of one-study remove to assess the influence of single study on the combined effect.
  
  
  RESULTS
  Eight studies were included in this study for meta-analysis. Rs1982073 was associated with high myopia in dominant model (OR=1.64; 95% CI=1.04~2.58; P<0.05), heterozygous model (OR=1.54; 95% CI=1.02~2.33; P<0.05), homozygous model (OR=1.90; 95% CI=1.01~3.55; P=0.05) and allelic model (OR=1.36; 95% CI=1.01~1.84; P=0.05). However, there was no statistical significance when Bonferroni correction was considered. Rs4803455 was associated with high myopia in recessive model (OR=0.40; 95% CI=0.25~0.64; P<0.01) and homozygous model (OR=0.42; 95% CI=0.26~0.68; P<0.01). Rs1800469 was associated with high myopia in allelic model (OR=0.78; 95% CI=0.64~0.96; P<0.05). And the associations can withstand Bonferroni correction in models mentioned above when referring to rs4803455 (P<0.01) and rs1800469 (P<0.05).
  
  
  CONCLUSIONS
  Meta-analysis of existing data revealed a suggestive association of TGFB1 rs1982073 and rs4803455 with high myopia.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science CentreBeijing 100191, China; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityBeijing 100005, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Meng
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University Beijing 100005, China.
authors.forename: Shi-Ming
authors.initials: SM
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre Beijing 100191, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre Beijing 100191, China.
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre Beijing 100191, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Sun
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University Beijing 100005, China.
authors.forename: Meng-Tian
authors.initials: MT
authors.lastname: Kang
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University Beijing 100005, China.
authors.forename: Yun-Yun
authors.initials: YY
authors.lastname: Sun
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University Beijing 100005, China.
authors.forename: An-Ran
authors.initials: AR
authors.lastname: Ran
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University Beijing 100005, China.
authors.forename: Jia-Nan
authors.initials: JN
authors.lastname: Wang
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University Beijing 100005, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Yan
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University Beijing 100005, China.
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: BaI
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University Beijing 100005, China.
authors.forename: Ning-Li
authors.initials: NL
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre Beijing 100191, China.
authors.forename: Si-Yan
authors.initials: SY
authors.lastname: Zhan
keywords: Transforming growth factor beta1; high myopia; single nucleotide polymorphism