title: De novo lipogenesis is suppressed during fasting but upregulated at population decline in cyclic voles.
abstract: Arvicolines are susceptible to the development of fatty liver during short-term fasting. We examined the potential role of de novo lipogenesis (DNL) (i) in the development of fasting-induced fatty liver and (ii) during a population cycle by measuring the mRNA expression of acetyl-CoA carboxylase-1 (ACC1) and fatty acid synthase (FAS). Laboratory voles (Microtus oeconomus and Microtus arvalis) were fed or fasted for 12 or 18 h and their liver mRNA levels were determined. Both species showed decreased mRNA expression of ACC1 and FAS during fasting. This suggests that DNL does not participate in the development of fatty liver in voles, different from human non-alcoholic fatty liver disease. In wild bank voles (Myodes glareolus), the mRNA levels of the genes of interest were higher during the population decline compared to the increase phase. In conclusion, DNL was suppressed during acute fasting but upregulated during a long-term population decline-a period of purported scarcity of high-quality food.
authors.affiliation: Department of Biomedicine/Anatomy, Faculty of Health Sciences, School of Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland Department of Environmental and Biological Sciences, Faculty of Science and Forestry, University of Eastern Finland, FI-80101 Joensuu, Finland petteri.nieminen@uef.fi.
authors.forename: Petteri
authors.initials: P
authors.lastname: Nieminen
authors.affiliation: Department of Plant and Animal Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS, B2N 5E3 Canada.
authors.forename: Kirsti
authors.initials: K
authors.lastname: Rouvinen-Watt
authors.affiliation: Department of Plant and Animal Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS, B2N 5E3 Canada.
authors.forename: Lora
authors.initials: L
authors.lastname: Harris
authors.affiliation: Natural Resources Institute Finland, Suonenjoki Unit, FI-77600 Suonenjoki, Finland.
authors.forename: Otso
authors.initials: O
authors.lastname: Huitu
authors.affiliation: Natural Resources Institute Finland, Vantaa Unit, FI-01301 Vantaa, Finland.
authors.forename: Heikki
authors.initials: H
authors.lastname: Henttonen
authors.affiliation: Department of Biomedicine/Anatomy, Faculty of Health Sciences, School of Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland Department of Environmental and Biological Sciences, Faculty of Science and Forestry, University of Eastern Finland, FI-80101 Joensuu, Finland.
authors.forename: Anne-Mari
authors.initials: AM
authors.lastname: Mustonen
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D003411:Arvicolinae / Q000378:metabolism / Q000502:physiology; D005215:Fasting / Q000502:physiology*; D064429:Fatty Acid Synthases / Q000378:metabolism; D005260:Female; D050155:Lipogenesis / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D008297:Male; D011157:Population Dynamics; D015854:Up-Regulation / Q000502:physiology
chemical_list: D000123:Acetyltransferases; C055210:aminoglycoside N1-acetyltransferase; D064429:Fatty Acid Synthases
keywords: Acetyl-CoA carboxylase-1; de novo lipogenesis; fatty acid synthase; population cycles