title: Effect of stents coated with a combination of sirolimus and alpha-lipoic acid in a porcine coronary restenosis model.
abstract: The aim of this study was to evaluate antiproliferative sirolimus- and antioxidative alpha-lipoic acid (ALA)-eluting stents using biodegradable polymer [poly-L-lactic acid (PLA)] in a porcine coronary overstretch restenosis model. Forty coronary arteries of 20 pigs were randomized into four groups in which the coronary arteries had a bare metal stent (BMS, n = 10), ALA-eluting stent with PLA (AES, n = 10), sirolimus-eluting stent with PLA (SES, n = 10), or sirolimus- and ALA-eluting stent with PLA (SAS, n = 10). A histopathological analysis was performed 28 days after the stenting. The ALA and sirolimus released slowly over 30 days. There were no significant differences between groups in the injury or inflammation score; however, there were significant differences in the percent area of stenosis (56.2 ± 11.78% in BMS vs. 51.5 ± 12.20% in AES vs. 34.7 ± 7.23% in SES vs. 28.7 ± 7.30% in SAS, P < 0.0001) and fibrin score [1.0 (range 1.0-1.0) in BMS vs. 1.0 (range 1.0-1.0) in AES vs. 2.0 (range 2.0-2.0) in SES vs. 2.0 (range 2.0-2.0) in SAS, P < 0.0001] between the four groups. The percent area of stenosis based on micro-computed tomography corresponded with the restenosis rates based on histopathological stenosis in different proportions in the four groups (54.8 ± 7.88% in BMS vs. 50.4 ± 14.87% in AES vs. 34.5 ± 7.22% in SES vs. 28.9 ± 7.22% in SAS, P < 0.05). SAS showed a better neointimal inhibitory effect than BMS, AES, and SES at 1 month after stenting in a porcine coronary restenosis model. Therefore, SAS with PLA can be a useful drug combination for coronary stent coating to suppress neointimal hyperplasia.
authors.affiliation: Korea Cardiovascular Stent Institute, Jangsung, Korea.|Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.|Cardiovascular Research Center, Chonnam National University Hospital, 671, Dong-gu, Gwangju, 501-757, Korea.
authors.forename: Kyung Seob
authors.initials: KS
authors.lastname: Lim
authors.affiliation: Department of Polymer Science and Engineering, Sunchon National University, Sunchon, Korea.
authors.forename: Jun-Kyu
authors.initials: JK
authors.lastname: Park
authors.affiliation: Korea Cardiovascular Stent Institute, Jangsung, Korea. inovation15@hotmail.com.|Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea. inovation15@hotmail.com.|Cardiovascular Research Center, Chonnam National University Hospital, 671, Dong-gu, Gwangju, 501-757, Korea. inovation15@hotmail.com.|Regeneromics Research Center, Chonnam National University, Gwangju, Korea. inovation15@hotmail.com.
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Jeong
authors.affiliation: Korea Cardiovascular Stent Institute, Jangsung, Korea.|Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.
authors.forename: In-Ho
authors.initials: IH
authors.lastname: Bae
authors.affiliation: Department of Polymer Science and Engineering, Sunchon National University, Sunchon, Korea.
authors.forename: Jae-Woon
authors.initials: JW
authors.lastname: Nah
authors.affiliation: Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.|Cardiovascular Research Center, Chonnam National University Hospital, 671, Dong-gu, Gwangju, 501-757, Korea.
authors.forename: Dae Sung
authors.initials: DS
authors.lastname: Park
authors.affiliation: Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.|Cardiovascular Research Center, Chonnam National University Hospital, 671, Dong-gu, Gwangju, 501-757, Korea.
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.|Cardiovascular Research Center, Chonnam National University Hospital, 671, Dong-gu, Gwangju, 501-757, Korea.
authors.forename: Jung Ha
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Korea Cardiovascular Stent Institute, Jangsung, Korea.|Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.
authors.forename: So Youn
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Korea Cardiovascular Stent Institute, Jangsung, Korea.|Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.
authors.forename: Eun Jae
authors.initials: EJ
authors.lastname: Jang
authors.affiliation: Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.|Cardiovascular Research Center, Chonnam National University Hospital, 671, Dong-gu, Gwangju, 501-757, Korea.
authors.forename: Suyoung
authors.initials: S
authors.lastname: Jang
authors.affiliation: Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.|Cardiovascular Research Center, Chonnam National University Hospital, 671, Dong-gu, Gwangju, 501-757, Korea.
authors.forename: Hyun Kuk
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.|Cardiovascular Research Center, Chonnam National University Hospital, 671, Dong-gu, Gwangju, 501-757, Korea.
authors.forename: Doo Sun
authors.initials: DS
authors.lastname: Sim
authors.affiliation: Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.|Cardiovascular Research Center, Chonnam National University Hospital, 671, Dong-gu, Gwangju, 501-757, Korea.
authors.forename: Keun-Ho
authors.initials: KH
authors.lastname: Park
authors.affiliation: Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.|Cardiovascular Research Center, Chonnam National University Hospital, 671, Dong-gu, Gwangju, 501-757, Korea.
authors.forename: Young Joon
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.|Cardiovascular Research Center, Chonnam National University Hospital, 671, Dong-gu, Gwangju, 501-757, Korea.
authors.forename: Youngkeun
authors.initials: Y
authors.lastname: Ahn
authors.affiliation: Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.|Cardiovascular Research Center, Chonnam National University Hospital, 671, Dong-gu, Gwangju, 501-757, Korea.
authors.forename: Jung Chaee
authors.initials: JC
authors.lastname: Kang
mesh_terms: D000818:Animals; D023903:Coronary Restenosis / Q000628:therapy*; D054855:Drug-Eluting Stents; D005347:Fibroblasts; D051381:Rats; D020123:Sirolimus / Q000737:chemistry / Q000494:pharmacology*; D013552:Swine; D008063:Thioctic Acid / Q000737:chemistry / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D008063:Thioctic Acid; D020123:Sirolimus