title: RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions.
abstract: RF-amide neuropeptides, with their typical Arg-Phe-NH2 signature at their carboxyl C-termini, belong to a lineage of peptides that spans almost the entire life tree. Throughout evolution, RF-amide peptides and their receptors preserved fundamental roles in reproduction and feeding, both in Vertebrates and Invertebrates. The scope of this review is to summarize the current knowledge on the RF-amide systems in Mammals from historical aspects to therapeutic opportunities. Taking advantage of the most recent findings in the field, special focus will be given on molecular and pharmacological properties of RF-amide peptides and their receptors as well as on their implication in the control of different physiological functions including feeding, reproduction and pain. Recent progress on the development of drugs that target RF-amide receptors will also be addressed.
authors.affiliation: Biotechnologie et Signalisation Cellulaire, UMR 7242 CNRS, Université de Strasbourg, Illkirch, France.
authors.forename: Raphaëlle
authors.initials: R
authors.lastname: Quillet
authors.affiliation: Biotechnologie et Signalisation Cellulaire, UMR 7242 CNRS, Université de Strasbourg, Illkirch, France.
authors.forename: Safia
authors.initials: S
authors.lastname: Ayachi
authors.affiliation: Laboratoire Innovation Thérapeutique, UMR 7200 CNRS, Université de Strasbourg, Illkirch, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bihel
authors.affiliation: Biotechnologie et Signalisation Cellulaire, UMR 7242 CNRS, Université de Strasbourg, Illkirch, France.
authors.forename: Khadija
authors.initials: K
authors.lastname: Elhabazi
authors.affiliation: Biotechnologie et Signalisation Cellulaire, UMR 7242 CNRS, Université de Strasbourg, Illkirch, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Ilien
authors.affiliation: Biotechnologie et Signalisation Cellulaire, UMR 7242 CNRS, Université de Strasbourg, Illkirch, France. Electronic address: simonin@unistra.fr.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Simonin
mesh_terms: D000577:Amides / Q000378:metabolism*; D000818:Animals; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D008322:Mammals / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D018013:Receptors, Neuropeptide / Q000378:metabolism*
chemical_list: D000577:Amides; D009479:Neuropeptides; D018013:Receptors, Neuropeptide
keywords: Drug discovery; Feeding; Pain; RF-amide neuropeptides; RF-amide receptors; Reproduction