title: CTA Characteristics of the Circle of Willis and Intracranial Aneurysm in a Chinese Crowd with Family History of Stroke.
abstract: OBJECTIVE
  The vascular morphology in crowd with family history of stroke remains unclear. The present study clarified the characteristics of the intracranial vascular CoW and prevalence of intracranial aneurysms in subjects with family history of stroke.
  
  
  METHODS
  A stratified cluster, random sampling method was used for subjects with family history of stroke among rural residents in Jixian, Tianjin, China. All the subjects underwent a physical examination, head computed tomography (CT) scan, and cephalic and cervical computed tomography angiography (CTA) scan. Anatomic variations in the Circle of Willis and cerebrovascular disease in this population were analyzed.
  
  
  RESULTS
  In the crowd with similar living environment, stable genetic background, and family history of stroke and without obvious nerve function impairment (1) hypoplasia or absence of A1 segment was significantly different in gender (male versus female: 9.8% versus 18.8%, p = 0.031), especially the right-side A1 (male versus female: 5.9% versus 16.4%, p = 0.004). (2) Hypoplasia or absence of bilateral posterior communicating arteries was more common in men than women (58.2% versus 45.3%, p = 0.032). Unilateral fetal posterior cerebral artery was observed more often in women than men (17.2% versus 8.5%, p = 0.028). (3) The percentage of subjects with incomplete CoW did not increase significantly with age. Compared to healthy Chinese people, the crowd had a higher percentage of incomplete CoW (p < 0.001). (4) No obvious correlation between risk factors and CoW was found. (5) The prevalence of aneurysm was 10.3% in the special crowd.
  
  
  CONCLUSIONS
  The certain variations of CoW showed significant relation to gender, but not to age in people with family history of stroke. The incomplete circle may be a dangerous factor that is independent of common risk factors for stroke and tend to lead to cerebral ischemia in the crowd with family history of stroke. The prevalence of intracranial aneurysm is comparatively high in the present subjects compared to other people.
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Zhang-ning
authors.initials: ZN
authors.lastname: Jin
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Wen-tao
authors.initials: WT
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Xin-wang
authors.initials: XW
authors.lastname: Cai
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Li-tong
authors.initials: LT
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Xiao-kui
authors.initials: XK
authors.lastname: Kang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Hai-ning
authors.initials: HN
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Nan-nan
authors.initials: NN
authors.lastname: Gao
authors.affiliation: Department of Neuro-Epidemiology, Tianjin Medical University General Hospital, TNI, 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Xian-jia
authors.initials: XJ
authors.lastname: Ning
authors.affiliation: Department of Neuro-Epidemiology, Tianjin Medical University General Hospital, TNI, 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Tu
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Feng-tan
authors.initials: FT
authors.lastname: Li
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Ying-jian
authors.initials: YJ
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Nai-xin
authors.initials: NX
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Shu-yuan
authors.initials: SY
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Jian-ning
authors.initials: JN
authors.lastname: Zhang
authors.affiliation: Department of Neuro-Epidemiology, Tianjin Medical University General Hospital, TNI, 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Jing-hua
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute (TNI), 154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Xin-yu
authors.initials: XY
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D002533:Cerebral Angiography; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D002681:China; D002941:Circle of Willis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000473:pathology*; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed