title: Ganglioglioma arising from olfactory sheath: A rare site of an uncommon tumor.
abstract: Gangliogliomas are rare slow growing tumors with a mixed population of dysplastic ganglion cells and glial components, reported at variable sites within the central nervous system, including the frontal, parietal and occipital lobes, the striatum, cerebellum, pituitary and pineal glands as well as the spinal cord. Rarely gangliogliomas have been reported arising within the cranial nerves, including the optic and trigeminal nerve. We present the first patient, to our knowledge, where such a tumor originated from the olfactory sheath. Migration defects leading to entrapment of sensory neurons during development is believed to be responsible for the pathogenesis of these lesions. The extent of surgical extirpation and histopathological anaplasia are important prognosticators. While gangliogliomas are rare tumors, it is crucial to consider them in the differential diagnosis of non-enhancing, poorly localized lesions along the cranial nerves.
authors.affiliation: Department of Neurosurgery, PGIMER Chandigarh, 1092 sector 18-C, Chandigarh 160 012, India. Electronic address: drnavi2007@yahoo.co.in.
authors.forename: Navneet
authors.initials: N
authors.lastname: Singla
authors.affiliation: Department of Histopathology, PGIMER Chandigarh, India.
authors.forename: Kirti
authors.initials: K
authors.lastname: Gupta
authors.affiliation: Department of Neurosurgery, PGIMER Chandigarh, 1092 sector 18-C, Chandigarh 160 012, India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Kapoor
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D018303:Ganglioglioma / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D009832:Olfactory Nerve / Q000473:pathology*
keywords: Cranial nerves; Ganglioglioma; Mixed glioneural tumor; Olfactory sheath