title: The impact of Primary Ciliary Dyskinesia on the upper respiratory tract.
abstract: Primary Ciliary Dyskinesia (PCD) is an autosomal recessive genetic condition affecting the function of motile cilia. The upper respiratory tract is lined with ciliated epithelium and hence a hallmark of PCD is the development, from the neonatal period onwards, of persisting secretion retention and suppurative infection in the middle ear, nose and facial sinuses [1]. This review aims to remind the clinician involved in the care of a patient with PCD of the complexities of making the diagnosis of chronic rhinosinusitis (CRS) and chronic otitis media with effusion (ChOME), the morbidity associated with CRS and ChOME and of current evidence of best practice for the management of these conditions.
authors.affiliation: Sydney Medical School, University of Sydney, NSW; Department of Thoracic Medicine, Concord Hospital, Sydney, NSW; Australian School of Advanced Medicine, Macquarie University, Sydney, NSW. Electronic address: Lucy.morgan@sswahs.nsw.gov.au.
authors.forename: Lucy C
authors.initials: LC
authors.lastname: Morgan
authors.affiliation: Sydney Medical School, University of Sydney, NSW; Australian School of Advanced Medicine, Macquarie University, Sydney, NSW; Department of ENT Surgery, The Children's Hospital at Westmead, Sydney, NSW.
authors.forename: Catherine S
authors.initials: CS
authors.lastname: Birman
mesh_terms: D014943:Global Health; D006801:Humans; D015994:Incidence; D007619:Kartagener Syndrome / Q000150:complications* / Q000175:diagnosis; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology
keywords: Chronic otitis media with effusion; Chronic rhinosinusitis; Primary ciliary dyskinesia