title: The Diagnostic Role of Vitamin D and Cathelicidin Levels in Pelvic Inflammatory Disease.
abstract: BACKGROUND
  The aim of this study was to evaluate the effect of 25-hydroxyvitamin D [25(OH)D] and cathelicidin levels on pelvic inflammatory disease [PID] in reproductive aged women.
  
  
  METHODS
  A total of 81 reproductive aged women, 43 with PID and 38 without PID, were included in the study. Five millilitres of venous blood were collected from subjects and controls for complete hemogram and serum for CRP, IL-6, 25(OH)D and cathelicidin.
  
  
  RESULTS
  There were significant differences between the study group and the control group for 25(OH)D (study group, 47.3 ± 2.01 ng/mL, control group, 28.38 ± 1.35 ng/mL, p = 0.001), for cathelicidin (study group, 165.56 ± 65.92 ng/mL, control group, 10.34 ± 6.48 ng/mL, p = 0.001). There was a positive correlation between 25(OH)D, cathelicidin, and other markers (WBC, CRP, and IL-6). Receiver operator curve analysis showed that the best cutoff value for 25(OH)D was 34.25 ng/mL, sensitivity 88%, and specificity 89%, and for cathelicidin 15 ng/mL, sensitivity 91%, specificity 90%.
  
  
  CONCLUSIONS
  25(OH)D and cathelicidin can be used as acute phase reactants like conventional markers in PID. Future studies are needed to understand the roles of these molecules in both diagnosis and follow-up of infectious situations.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Çekmez
authors.forename: Doğa
authors.initials: D
authors.lastname: Öcal
authors.forename: Vakkas
authors.initials: V
authors.lastname: Korkmaz
authors.forename: Erdim
authors.initials: E
authors.lastname: Sertoğlu
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Uçar
authors.forename: Tuncay
authors.initials: T
authors.lastname: Küçüközkan
mesh_terms: D000328:Adult; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D000292:Pelvic Inflammatory Disease / Q000097:blood / Q000175:diagnosis*; D011446:Prospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D054804:Cathelicidins
chemical_list: D023181:Antimicrobial Cationic Peptides; D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D054804:Cathelicidins