title: Specific Antivirulence Activity, A New Concept for Reliable Screening of Virulence Inhibitors.
abstract: Antivirulence therapy, disarming pathogens rather than killing them, is emerging as a novel strategy for disease control. Reporter strains expressing an easily measurable and quantifiable phenotype enable easy screening of virulence inhibitors. In this paper I propose a novel concept to exclude false positives in this type of screening.
authors.affiliation: Laboratory of Aquaculture and Artemia Reference Center, Ghent University, 9000 Gent, Belgium. Electronic address: Tom.Defoirdt@UGent.be.
authors.forename: Tom
authors.initials: T
authors.lastname: Defoirdt
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D001419:Bacteria / Q000187:drug effects* / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D014774:Virulence / Q000187:drug effects; D037521:Virulence Factors / Q000037:antagonists & inhibitors*
chemical_list: D000900:Anti-Bacterial Agents; D037521:Virulence Factors
keywords: antivirulence therapy; disease; infection; pathogen; quorum sensing; virulence factor