title: Transient Microneedle Insertion into Hippocampus Triggers Neurogenesis and Decreases Amyloid Burden in a Mouse Model of Alzheimer's Disease.
abstract: Targeted microlesions of the hippocampus have been reported to enhance neurogenesis in the subgranular zone (SGZ). The potential therapeutic impact of transient insertion of a microneedle was investigated in a mouse model of Alzheimer's disease (AD). We tested the hypothesis that transient microinjury to the brain elicits cellular responses that mediate beneficial regenerative processes. Brief stereotaxic insertion and removal of a microneedle into the right hippocampus of 14-month-old APP/PS1 mouse brains resulted in (a) stimulation of hippocampal neurogenesis and (b) reduction of amyloid-β plaque number in the CA-1 region. This treatment also resulted in a trend toward improved performance in the radial arm water maze (RAWM). Further studies of fundamental cellular mechanisms of the brain's response to microinjury will be useful for investigation of potential neuroprotective and deleterious effects of targeted microlesions and deep brain stimulation in AD.
authors.affiliation: James Haley VA Medical Center, Tampa, FL, USA.|Department of Neurology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.|Department of Neurosurgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
authors.forename: Shijie
authors.initials: S
authors.lastname: Song
authors.affiliation: James Haley VA Medical Center, Tampa, FL, USA.|Department of Neurosurgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
authors.forename: Xiaoyung
authors.initials: X
authors.lastname: Kong
authors.affiliation: Department of Neurology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
authors.forename: Vasyl
authors.initials: V
authors.lastname: Sava
authors.affiliation: Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
authors.forename: Chuanhai
authors.initials: C
authors.lastname: Cao
authors.affiliation: Department of Neurosurgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
authors.forename: Sandra
authors.initials: S
authors.lastname: Acosta
authors.affiliation: Department of Neurosurgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
authors.forename: Cesar
authors.initials: C
authors.lastname: Borlongan
authors.affiliation: James Haley VA Medical Center, Tampa, FL, USA.|Department of Neurology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Sanchez-Ramos
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D018782:Maze Learning; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009339:Needles; D055495:Neurogenesis; D009842:Oligopeptides / Q000235:genetics / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D009842:Oligopeptides; C449186:PS1 antigen
keywords: Alzheimer's Disease (AD); Amyloid-β (Aβ); Microneedle stimulation; Neurogenesis; Transgenic APP/PS1 mice