title: Long noncoding RNA ENST00000434223 suppressed tumor progression in non-small cell lung cancer.
abstract: In spite of the fact that the great progress has been made in the treatment of non-small cell lung cancer (NSCLC), the prognosis of NSCLC remains comparatively dismal. Therefore, it is of great value to identify novel effective diagnostic biomarkers and therapeutic targets of NSCLC. Emerging evidence has demonstrated the vital roles of long noncoding RNAs (lncRNAs) in cancer development. ENST00000434223 was recently identified as a lncRNA that is downregulated in early stage lung adenocarcinoma in a profiling study. However, little is known about its role in the development of NSCLC. In the present study, we found that ENST00000434223 was greatly downregulated in cancer tissues compared to adjacent normal tissues. ENST00000434223 overexpression suppressed the proliferation and migration in NSCLC cell lines in vitro. Moreover, ENST00000434223 overexpression reversed the epithelial-mesenchymal transition in NSCLC cell line. Our study suggests that ENST00000434223 may be a potential biomarker and a therapeutic target of NSCLC.
authors.affiliation: School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.|Department of Pathology, the Affiliated Cancer Hospital to Zhengzhou University, Zhengzhou, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Chai
authors.affiliation: Department of Shanghai Lung Tumor Clinical Medical Centre, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xiangyun
authors.initials: X
authors.lastname: Ye
authors.affiliation: Department of Haematology, the Affiliated Cancer Hospital to Zhengzhou University, 127 Dongming road, Zhengzhou, 450008, China. syp201016@sina.com.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics*; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000473:pathology*; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D005260:Female; D005434:Flow Cytometry; D064593:Heterografts; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D062085:RNA, Long Noncoding / Q000096:biosynthesis / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; C000614038:LINC00342 long noncoding RNA, human; D062085:RNA, Long Noncoding
keywords: ENST00000434223; Epithelial-mesenchymal-transition; Long noncoding RNA; Non-small cell lung cancer