title: Serum myeloid-related protein 8/14 in minimal change- and glomerulonephritis-related nephrotic syndrome.
abstract: BACKGROUND
  Myeloid-related protein 8/14 (MRP8/14) forms stable heterodimers and is the major calcium-binding protein secreted by activated granulocytes and monocytes. We evaluated whether serum MRP8/14 level is a useful indicator for a differential diagnosis of glomerulonephritis (GN)- and minimal change disease (MC)- related nephrotic syndrome (NS).
  
  
  METHODS
  Serum MRP8/14 complex was evaluated in 37 NS patients with MC or GN. These patients were divided into two groups. Group 1 consisted of 13 NS patients with MC, and group 2 consisted of 24 NS patients with GN. Group 2 was further divided into four subgroups: IgA nephropathy (IgAN; n = 5), Henoch-Schönlein purpura nephritis (HSPN; n = 6), focal segmental glomerulosclerosis (FSGS; n = 12), and acute GN Poststreptococcal acute glomeruloNephritis (PSAGN; n = 1).
  
  
  RESULTS
  The clinical manifestations, laboratory findings, serum MRP8/14 level, and renal accumulation of MRP8 were investigated for each group. No significant inter-group differences were observed for serum total protein, serum albumin, or blood urea nitrogen and urinary protein excretions. Mean serum MRP8/14 in the IgAN, HSPN, FSGS, and PSAGN groups was higher than in group 1. Further, the mean glomerular and interstitial MRP8 staining scores in the IgAN, HSPN, and PSAGN groups were higher than in group 1.
  
  
  CONCLUSIONS
  Serum MRP8/14 level may be a useful indicator for differential diagnosis between GN- and MC- related NS.
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ohara
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan. kyuki@fmu.ac.jp.
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Kawasaki
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Maeda
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Syuto
authors.initials: S
authors.lastname: Kanno
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Suyama
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Hosoya
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D001806:Blood Urea Nitrogen; D040502:Calgranulin B / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005921:Glomerulonephritis / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D009402:Nephrosis, Lipoid / Q000097:blood* / Q000175:diagnosis; D009404:Nephrotic Syndrome / Q000097:blood* / Q000175:diagnosis; D012189:Retrospective Studies
chemical_list: C435500:ABCC11 protein, human; D018528:ATP-Binding Cassette Transporters; D015415:Biomarkers; D040502:Calgranulin B
keywords: Henoch-Schönlein purpura nephritis; IgA nephropathy; focal segmental glomerulosclerosis; myeloid-related protein 8/14 complex; nephrotic syndrome