title: Computed Tomographic Scoring Systems in Sarcoidosis: Comparison With Cardiopulmonary Exercise Testing Parameters.
abstract: OBJECTIVE
  The aim of the study was to correlate computed tomographic (CT) scoring systems for pulmonary sarcoidosis with cardiopulmonary exercise testing and evaluate which scoring system provides the most reliable information for assessing disease severity and predicting impairment of gas exchange during exercise.
  
  
  METHODS
  The institutional review board approved this retrospective study. All 62 patients underwent thin-section CT, pulmonary function tests, and cardiopulmonary exercise test. Two observers scored CT images according to scoring systems published by Remy-Jardin and colleagues. Spearman rank correlation coefficients were calculated between CT patterns and pulmonary functional impairment parameters, and multiple regression analyses were performed to evaluate which CT abnormalities were significantly associated with pulmonary functional impairment parameters.
  
  
  RESULTS
  Regardless of scoring system, PaO2max was significantly associated with the subscores of ground-glass opacity, linear opacity, and total CT scores. Multiple regression analyses showed that subscores of ground-glass and linear opacity in the Leung scoring system appeared to explain a significant amount of variance in functional parameters at rest and at maximal exercise.
  
  
  CONCLUSIONS
  CT findings, particularly ground-glass opacity and linear abnormalities, can explain a significant amount of variance in cardiopulmonary exercise parameters. This suggests that CT-based scoring systems are valid measures of disease severity in sarcoidosis.
authors.affiliation: Departments of *Radiology †Medicine, Division of Pulmonary and Critical Care Sciences, National Jewish Health, University of Colorado Denver School of Medicine, Denver, CO ‡Department of Biomedical Sciences, School of Medicine, Inha University, Incheon, Korea.
authors.forename: Yeon Joo
authors.initials: YJ
authors.lastname: Jeong
authors.forename: David A
authors.initials: DA
authors.lastname: Lynch
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Rho
authors.forename: Nabeel Y
authors.initials: NY
authors.lastname: Hamzeh
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Suh
mesh_terms: D000328:Adult; D000368:Aged; D005080:Exercise Test; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012129:Respiratory Function Tests / Q000706:statistics & numerical data; D012189:Retrospective Studies; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed