title: Association of the interleukin-18 receptor 1 and interleukin-18 receptor accessory protein polymorphisms with the risk of esophageal cancer.
abstract: Esophageal cancer is the fourth leading cause of cancer-associated fatalities and the fourth most commonly diagnosed cancer. In addition to environmental risk factors, genetic factors may have a significant role in esophageal cancer carcinogenesis. A hospital-based case-control study was conducted to evaluate the genetic effects of functional single-nucleotide polymorphisms in the interleukin-18 (IL-18), IL-18 receptor 1 protein (IL-18R1), IL-18 receptor accessory protein (IL-18RAP) andIL-28Bon the development of esophageal cancer. In total, 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for the present study. TheIL-18rs360719 A>G,IL-18R1rs13015714 G>T,IL-18RAPrs917997 C>T andIL-28Brs8099917 T>G genotypes were determined. No association was observed between theIL-18R1rs13015714 G>T,IL-18RAPrs917997 C>T andIL-28Brs8099917 T>G polymorphisms and the risk of ESCC. However, in stratification analyses, a significantly decreased risk of ESCC associated with theIL-18R1rs13015714 G>T polymorphism and a significantly increased risk of ESCC associated with theIL-18RAPrs917997 C>T polymorphism was evident among male patients and patients who smoked or consumed alcohol. These findings highlighted that functional polymorphismsIL-18R1rs13015714 G>T andIL-18RAPrs917997 C>T may contribute to ESCC susceptibility among these subgroups. However, the present results were obtained with a limited sample size and further epidemiological studies are warranted to clarify the role ofIL-18R1andIL-18RAPvariants in the development of ESCC.
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China.
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, P.R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Teng
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Cardiothoracic Surgery, The First People's Hospital of Changzhou and The Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu 213003, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Cancer Institute, Department of Chemotherapy, People's Hospital Affiliated to Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China.
authors.forename: Liming
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China.
authors.forename: Haiyong
authors.initials: H
authors.lastname: Gu
authors.affiliation: Department of Laboratory Medicine, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221000, P.R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Gu
authors.affiliation: Department of Thoracic and Cardiac Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
keywords: esophageal cancer; interleukin-18; interleukin-18 receptor 1; interleukin-18 receptor accessory protein; molecular epidemiology; polymorphisms