title: Two cases of primary non-Hodgkin's lymphoma of female breast: Role of fine-needle aspiration cytology and cell-block immunohistochemistry.
abstract: Primary breast lymphoma (PBL) is an uncommon neoplastic condition. Though HIV-infection is a known risk factor for the development of extranodal lymphomas, mammary involvement is still a rarity. Radiologically, PBL appears as well circumscribed, heteroechoic, noncalcifying mass. Fine-needle aspiration cytology (FNAC) is commonly used to diagnose this neoplasm; however, subcategorization requires immunophenotypic characterization of the neoplastic cells. Herein, we report two cases of PBL, including a HIV-infected lady; in both the cases FNAC expressed features of non-Hodgkin's lymphoma. Finally, immunohistochemistry on cell-block with CD20 diagnosed both the cases as diffuse large B-cell lymphoma (DLBCL).
authors.affiliation: Department of Pathology, Malda Medical College, West Bengal University of Health Sciences, Malda, West Bengal, India.
authors.forename: Tarak
authors.initials: T
authors.lastname: Banik
authors.affiliation: Department of Pathology, Malda Medical College, West Bengal University of Health Sciences, Malda, West Bengal, India.
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Mondal
authors.affiliation: Department of Pathology, Malda Medical College, West Bengal University of Health Sciences, Malda, West Bengal, India.
authors.forename: Rupali
authors.initials: R
authors.lastname: Mandal
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016483:Lymphoma, AIDS-Related / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008875:Middle Aged
keywords: breast; cell block; diffuse large B-cell lymphoma; fine-needle aspiration cytology; non-Hodgkin's lymphoma