title: The Role of Maternal-Effect Genes in Mammalian Development: Are Mammalian Embryos Really an Exception?
abstract: The essential contribution of multiple maternal factors to early mammalian development is rapidly altering the view that mammals have a unique pattern of development compared to other species. Currently, over 60 maternal-effect mutations have been described in mammalian systems, including critical determinants of pluripotency. This data, combined with the evidence for lineage bias and differential gene expression in early blastomeres, strongly suggests that mammalian development is to some extent mosaic from the four-cell stage onward.
authors.affiliation: Department of Neurobiology, School of Medicine, University of Utah, 20 South 2030 East, Bldg. 570 BPRB, Salt Lake City, UT, 84112, USA. mlcondic@neuro.utah.edu.
authors.forename: Maureen L
authors.initials: ML
authors.lastname: Condic
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D004622:Embryo, Mammalian / Q000502:physiology*; D047108:Embryonic Development / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D006801:Humans; D033261:Maternal-Fetal Relations / Q000502:physiology*
keywords: Cell fate determination; Determinative development; Embryonic lethal; Mammalian embryo; Maternal effect; Pluripotency; Regulative development