title: Baicalin inhibits PDGF-induced proliferation and migration of airway smooth muscle cells.
abstract: Airway smooth muscle (ASM) cell proliferation and migration play important roles in airway remodeling in asthma. In vitro platelet-derived growth factor (PDGF) induced ASM cell proliferation and migration. Baicalin is one of flavonoid extracts from Scutellaria baicalensis, which has an anti-asthma effect. However, little is known about its role in PDGF-induced proliferation and migration in rat ASM (RASM) cells. In this study, we aimed to investigate the effects of baicalin on PDGF-induced RASM cell proliferation and migration. We also identified the signaling pathway by which baicalin influences RASM cell proliferation and migration. In the current study, we demonstrated that baicalin suppressed PDGF-induced RASM cell proliferation, arrested PDGF-induced cell-cycle progression. It also suppressed PDGF-induced RASM cell migration. Furthermore, baicalin suppressed PDGF-induced expression of phosphorylated p38, ERK1/2 and JNK in RASM cells. In summary, our study is the first to show that baicalin pretreatment can significantly inhibit PDGF-induced RASM cell proliferation and migration by suppressing the MAPK signaling pathway, and baicalin may be a useful chemotherapeutic agent for asthma.
authors.affiliation: Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University Taiyuan 030001, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University Taiyuan 030001, China.
authors.forename: Jian-Qiang
authors.initials: JQ
authors.lastname: Li
authors.affiliation: Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University Taiyuan 030001, China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Bo
authors.affiliation: Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University Taiyuan 030001, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University Taiyuan 030001, China.
authors.forename: Xin-Rui
authors.initials: XR
authors.lastname: Tian
authors.affiliation: Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University Taiyuan 030001, China.
authors.forename: Tan-Zhen
authors.initials: TZ
authors.lastname: Liu
authors.affiliation: Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University Taiyuan 030001, China.
authors.forename: Zhuo-La
authors.initials: ZL
authors.lastname: Liu
keywords: Baicalin; migration; proliferation; rat airway smooth muscle (RASM) cell