title: Epidermal growth factor and prostaglandin E2 levels in Helicobacter pylori-positive gastric intraepithelial neoplasia.
abstract: OBJECTIVE
  To investigate levels of epidermal growth factor (EGF) and prostaglandin E2 (PGE2) in Han Chinese patients with Helicobacter pylori-positive gastric low-grade intraepithelial neoplasia (LGIN).
  
  
  METHODS
  In this prospective, observational study, gastric specimens from patients with LGIN were collected by gastroscopy with consecutive biopsy. EGF and PGE2 concentrations in serum and gastric juice from patients with LGIN were measured by enzyme-linked immunosorbent assay. Presence of H. pylori infection was assessed in patients with LGIN and healthy controls.
  
  
  RESULTS
  Out of 5 638 patients and 548 controls, H. pylori infection in patients with chronic gastritis was associated with disease type (endoscopic classification) and disease severity. Patients with H. pylori-positive LGIN had significantly higher concentrations of serum EGF and lower concentrations of serum PGE2 versus patients with H. pylori-negative LGIN. Serum EGF and PGE2 levels in patients with LGIN were not significantly associated with disease type, but were significantly associated with disease severity.
  
  
  CONCLUSIONS
  H. pylori infection was associated with chronic gastritis type (endoscopic classification) and disease severity. Abnormal EGF and PGE2 levels may be associated with H. pylori-positive LGIN in Han Chinese patients in central China.
authors.affiliation: Department of Gastroenterology and Central Laboratory, Central Hospital of Wuhan, Wuhan, China.
authors.forename: Zhitao
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology and Central Laboratory, Central Hospital of Wuhan, Wuhan, China wujie_20120803@163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Gastroenterology and Central Laboratory, Central Hospital of Wuhan, Wuhan, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology and Central Laboratory, Central Hospital of Wuhan, Wuhan, China.
authors.forename: Manling
authors.initials: M
authors.lastname: Huang
authors.affiliation: Department of Gastroenterology and Central Laboratory, Central Hospital of Wuhan, Wuhan, China.
authors.forename: Shengbin
authors.initials: S
authors.lastname: Sun
authors.affiliation: Department of Gastroenterology and Central Laboratory, Central Hospital of Wuhan, Wuhan, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology and Central Laboratory, Central Hospital of Wuhan, Wuhan, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Gastroenterology and Central Laboratory, Central Hospital of Wuhan, Wuhan, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D002681:China; D015232:Dinoprostone / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005750:Gastric Juice / Q000737:chemistry; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D005773:Gastroscopy; D015870:Gene Expression; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D016480:Helicobacter pylori / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology
chemical_list: D004815:Epidermal Growth Factor; D015232:Dinoprostone
keywords: Chronic gastritis; Helicobacter pylori; epidermal growth factor; gastric intraepithelial neoplasia; prostaglandin E2