title: The oral and craniofacial relevance of chemically modified RNA therapeutics.
abstract: Several tissue engineering strategies in the form of protein therapy, gene therapy, cell therapy, and their combinations are currently being explored for oral and craniofacial regeneration and repair. Though each of these approaches has advantages, they all have common inherent drawbacks of being expensive and raising safety concerns. Using RNA (encoding therapeutic protein) has several advantages that have the potential to overcome these limitations. Chemically modifying the RNA improves its stability and mitigates immunogenicity allowing for the potential of RNA to become an alternative to protein and gene based therapies. This brief review article focuses on the potential of RNA therapeutics in the treatment of disorders in the oral and craniofacial regions.
authors.affiliation: Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242, USA.
authors.forename: Satheesh
authors.initials: S
authors.lastname: Elangovan
authors.affiliation: Department of Pediatrics I-Pediatric Infectiology, Immunology and Cystic Fibrosis, Translational Genomics and Gene Therapy, Wilhelmstr. 56, 72074 Tübingen, Germany.
authors.forename: Michael S D
authors.initials: MS
authors.lastname: Kormann
authors.affiliation: Division of Pharmaceutics and Translational Therapeutics, University of Iowa College of Pharmacy, Iowa City, IA 52242, USA.
authors.forename: Behnoush
authors.initials: B
authors.lastname: Khorsand
authors.affiliation: Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242, USA.|Division of Pharmaceutics and Translational Therapeutics, University of Iowa College of Pharmacy, Iowa City, IA 52242, USA.
authors.forename: Aliasger K
authors.initials: AK
authors.lastname: Salem
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009059:Mouth Diseases / Q000628:therapy*; D012313:RNA / Q000737:chemistry* / Q000627:therapeutic use*; D044968:Regenerative Medicine / Q000379:methods*
chemical_list: D012313:RNA