title: MicroRNA-205 increases the sensitivity of docetaxel in breast cancer.
abstract: Chemotherapy has been widely used in breast cancer therapy, but the efficacy of chemotherapy is intimately associated with the sensitivity of therapeutic drugs to breast cancer. Docetaxel is a first-line chemotherapeutic drug in breast cancer treatment, but further improvement to its efficacy has thus far proved difficult. microRNAs (miRs) are a class of endogenous, small, non-coding RNAs, which regulate gene expression at the post-transcriptional level. miR-205, a regulator of HER-3, is reported to be a tumor suppressor in breast cancer. In the present study, the reintroduction of miR-205 is shown to inhibit cell proliferation and clonogenic potential, and increase the sensitivity of MCF-7 and MDA-MB-231 cells to docetaxel. miR-205 also shows a synergistic effect with docetaxelin vivo. The present study provides a novel strategy to increase the sensitivity to docetaxel in breast cancer patients.
authors.affiliation: Department of Medical Oncology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Department of Medical Oncology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Medical Oncology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Medical Oncology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
authors.forename: Shunchang
authors.initials: S
authors.lastname: Jiao
keywords: breast cancer; docetaxel; miR-205