title: Hippocampal subfield volumetry in patients with subcortical vascular mild cognitive impairment.
abstract: Memory impairment is a typical characteristic of patients with subcortical vascular mild cognitive impairment (svMCI) or with amnestic mild cognitive impairment (aMCI). The hippocampus, which plays an important role in the consolidation of information from short-term memory to long-term memory, is a heterogeneous structure that consists of several anatomically and functionally distinct subfields. However, whether distinct hippocampal subfields are differentially and selectively affected by svMCI pathology and whether these abnormal changes in hippocampal subfields are different between svMCI and aMCI patients are largely unknown. A total of 26 svMCI patients, 26 aMCI patients and 26 healthy controls matched according to age, gender and years of education were enrolled in this study. We utilized an automated hippocampal subfield segmentation method provided by FreeSurfer to estimate the volume of several hippocampal subfields, including the cornu ammonis (CA) areas, the dentate gyrus (DG), the subiculum and the presubiculum. Compared with controls, the left subiculum and presubiculum and the right CA4/DG displayed significant atrophy in patients with svMCI. Interestingly, we also found significant differences in the volume of the right CA1 between the svMCI and aMCI groups. Taken together, our results reveal region-specific vulnerability of hippocampal subfields to svMCI pathology and identify distinct hippocampal subfield atrophy patterns between svMCI and aMCI patients.
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science &Medical Engineering, Beihang University, Beijing, 100191, China.
authors.forename: Xinwei
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science &Medical Engineering, Beihang University, Beijing, 100191, China.
authors.forename: Deyu
authors.initials: D
authors.lastname: Li
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science &Medical Engineering, Beihang University, Beijing, 100191, China.
authors.forename: Qiongling
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, 100053, China.|Department of Neurology, Tangshan Gongren Hospital, Tangshan, 063000, China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Radiology, Xuan Wu Hospital, Capital Medical University, Beijing, 100053, China.
authors.forename: Kuncheng
authors.initials: K
authors.lastname: Li
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science &Medical Engineering, Beihang University, Beijing, 100191, China.
authors.forename: Shuyu
authors.initials: S
authors.lastname: Li
authors.affiliation: Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China.|Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, 100053, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D001284:Atrophy; D001931:Brain Mapping; D056547:CA1 Region, Hippocampal / Q000473:pathology* / Q000503:physiopathology; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D018891:Dentate Gyrus / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D057567:Memory, Long-Term; D008570:Memory, Short-Term; D008875:Middle Aged