title: Exploring Cellular Interactions of Liposomes Using Protein Corona Fingerprints and Physicochemical Properties.
abstract: To control liposomes fate and transport upon contact with biofluids, it is essential to consider several parameters affecting the synthetic and biological identity of liposomes, as well as liposome-protein corona (PC) aspects. As a powerful tool in this data mining adventure, quantitative structure-activity relationship (QSAR) approach is used to correlate physicochemical properties of liposomes and their PC fingerprints to multiple quantified biological responses. In the present study, the relationship between cellular interactions of a set of structurally diverse liposomal formulations and their physicochemical and PC properties has been investigated via linear and nonlinear QSAR models. Significant parameters affecting cellular uptake and cell viability of liposomes in two important cancer cell lines (PC3 and HeLa) have been identified. The developed QSARs have the capacity to be implemented in advanced targeted delivery of liposomal drugs.
authors.affiliation: Department of Chemistry, Sharif University of Technology , Tehran 1113658639, Iran.
authors.forename: Arafeh
authors.initials: A
authors.lastname: Bigdeli
authors.affiliation: Department of Molecular Medicine, "Sapienza" University of Rome , Rome 00185, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Palchetti
authors.affiliation: Department of Molecular Medicine, "Sapienza" University of Rome , Rome 00185, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Pozzi
authors.affiliation: Department of Chemistry, Sharif University of Technology , Tehran 1113658639, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Hormozi-Nezhad
authors.affiliation: Department of Chemistry, Materials and Chemical Engineering Giulio Natta, Politecnico di Milano , Milan 20133, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Baldelli Bombelli
authors.affiliation: Department of Molecular Medicine, "Sapienza" University of Rome , Rome 00185, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Caracciolo
authors.affiliation: Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran 1316943551, Iran.|Stanford Cardiovascular Institute and Division of Cardiovascular Medicine, Stanford University School of Medicine , Stanford, California 94305, United States.
authors.forename: Morteza
authors.initials: M
authors.lastname: Mahmoudi
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism* / Q000493:pharmacokinetics; D008958:Models, Molecular; D009369:Neoplasms / Q000378:metabolism; D010449:Peptide Mapping; D000066970:Protein Corona / Q000032:analysis / Q000378:metabolism*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D008081:Liposomes; D000066970:Protein Corona
keywords: QSAR; cancer; cell viability; cellular uptake; liposomes; protein corona