title: Sarcopenia as a Risk Factor for Cognitive Deterioration in Community-Dwelling Older Adults: A 1-Year Prospective Study.
abstract: OBJECTIVE
  The purpose of this 1-year prospective study was to determine whether sarcopenia is an independent risk factor of cognitive deterioration in community-dwelling older adults.
  
  
  METHODS
  One-year prospective study.
  
  
  METHODS
  Japanese community.
  
  
  METHODS
  A total of 131 community-dwelling older adults aged 65 years and older participated in this study.
  
  
  METHODS
  We defined sarcopenia using the diagnostic algorithm recommended by the Asian Working Group for Sarcopenia, and the participants were classified into the sarcopenia and normal groups according to this definition. The participants' cognitive functions were assessed using the Mini-Mental State Examination (MMSE) during pre- and postdata collection (after 1 year).
  
  
  RESULTS
  The rate of change in pre- and post-MMSE scores during the follow-up term was significantly different between the 2 groups (normal group, -0.32 ± 8.39%; sarcopenia group, -5.86 ± 5.16%; P = .002). The analysis of covariance, adjusted for demographic data and the pre-MMSE scores, showed a significant change in the MMSE scores between the normal and sarcopenia group (F = 9.30, P = .003). Furthermore, in the multivariate logistic regression analysis, the cognitive function was significantly more likely to deteriorate (defined as a loss of at least 2 points of MMSE) in the sarcopenia group during the follow-up term (odds ratio: 7.86, 95% confidence interval: 1.53-40.5).
  
  
  CONCLUSIONS
  Sarcopenia was identified as an independent risk factor of cognitive deterioration in community-dwelling older adults during the 1-year study period.
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Japan Society for the Promotion of Science, Tokyo, Japan. Electronic address: shu.nsgc.kupt@gmail.com.
authors.forename: Shu
authors.initials: S
authors.lastname: Nishiguchi
authors.affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamada
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Shirooka
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Yuma
authors.initials: Y
authors.lastname: Nozaki
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Fukutani
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Yuto
authors.initials: Y
authors.lastname: Tashiro
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Hinako
authors.initials: H
authors.lastname: Hirata
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Moe
authors.initials: M
authors.lastname: Yamaguchi
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Seishiro
authors.initials: S
authors.lastname: Tasaka
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Matsushita
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Matsubara
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Tadao
authors.initials: T
authors.lastname: Tsuboyama
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Aoyama
mesh_terms: D000368:Aged; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D055948:Sarcopenia / Q000175:diagnosis / Q000503:physiopathology*
keywords: Sarcopenia; cognitive deterioration; community-dwelling older adults; prospective study