title: Surgical outcome and patterns of recurrence for retroperitoneal sarcoma at a single centre.
abstract: BACKGROUND
  Retroperitoneal sarcoma is a surgically managed condition that can recur locally following macroscopically complete resection. Owing to the low incidence of the condition, advances in treatment are reported infrequently but complete compartmental resection and adjuvant or neoadjuvant radiotherapy are areas under investigation. Given the practical difficulty of randomised trials, observational data can highlight advantages from progressive treatment approaches.
  
  
  METHODS
  A retrospective database of consecutive retroperitoneal sarcoma resections performed at a single referral centre between March 1997 and March 2013 was interrogated. Histological, radiological and clinical data were collected. Univariate and multivariate analyses for disease free and overall survival were performed to establish independent predictors of disease recurrence and patient survival.
  
  
  RESULTS
  A total of 79 patients underwent 90 resections (63 primary). The mean five-year overall and disease free survival rates were 55.3% and 24.8% respectively. Higher patient age, high tumour grade, presence of extraretroperitoneal disease and invasive tumour phenotype were found to significantly predict survival following multivariate analysis. Half (50%) of the tumours displayed invasive behaviour on histopathology and 42% of locoregional recurrence was intraperitoneal.
  
  
  CONCLUSIONS
  Retroperitoneal sarcoma is commonly an infiltrative tumour and often recurs outside of the retroperitoneum. These features limit the therapeutic impact of interventions that focus on gaining local control such as complete compartmental resection and radiotherapy. It seems likely that future advances in the management of this cancer will involve new systemic agents to treat this frequently systemic disease.
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust , UK.
authors.forename: H D J
authors.initials: HD
authors.lastname: Hogg
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust , UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Manas
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust , UK.
authors.forename: D
authors.initials: D
authors.lastname: Lee
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust , UK.
authors.forename: P
authors.initials: P
authors.lastname: Dildey
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust , UK.
authors.forename: J
authors.initials: J
authors.lastname: Scott
authors.affiliation: Newcastle University , UK.
authors.forename: J
authors.initials: J
authors.lastname: Lunec
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust , UK.
authors.forename: J J
authors.initials: JJ
authors.lastname: French
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery*; D012186:Retroperitoneal Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D012509:Sarcoma / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Disease free survival; Invasion; Overall survival; Recurrence; Retroperitoneal sarcoma; Soft tissue sarcoma