title: Effects of memory on the shapes of simple outbreak trees.
abstract: Genomic tools, including phylogenetic trees derived from sequence data, are increasingly used to understand outbreaks of infectious diseases. One challenge is to link phylogenetic trees to patterns of transmission. Particularly in bacteria that cause chronic infections, this inference is affected by variable infectious periods and infectivity over time. It is known that non-exponential infectious periods can have substantial effects on pathogens' transmission dynamics. Here we ask how this non-Markovian nature of an outbreak process affects the branching trees describing that process, with particular focus on tree shapes. We simulate Crump-Mode-Jagers branching processes and compare different patterns of infectivity over time. We find that memory (non-Markovian-ness) in the process can have a pronounced effect on the shapes of the outbreak's branching pattern. However, memory also has a pronounced effect on the sizes of the trees, even when the duration of the simulation is fixed. When the sizes of the trees are constrained to a constant value, memory in our processes has little direct effect on tree shapes, but can bias inference of the birth rate from trees. We compare simulated branching trees to phylogenetic trees from an outbreak of tuberculosis in Canada, and discuss the relevance of memory to this dataset.
authors.affiliation: Department of Mathematics, Imperial College London, London, UK.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Plazzotta
authors.affiliation: Department of Electrical and Electronic Engineering, Imperial College London, London, UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: Kwan
authors.affiliation: Department of Mathematics, University of Cambridge, Cambridge, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Boyd
authors.affiliation: Department of Mathematics, Imperial College London, London, UK.
authors.forename: Caroline
authors.initials: C
authors.lastname: Colijn
mesh_terms: D001419:Bacteria / Q000235:genetics*; D002170:Canada / Q000453:epidemiology; D004196:Disease Outbreaks; D006801:Humans; D008957:Models, Genetic; D010802:Phylogeny; D014376:Tuberculosis / Q000453:epidemiology / Q000235:genetics