title: Chronic liquid nutrition feeding affects blood pressure, heart and kidney morphology, and serum lipid profile in Wistar rats.
abstract: We determined the effect of chronic liquid nutrition (Fresubin) intake in different developmental stages on the cardiovascular and renal system of male Wistar rats. Body weight, water intake and blood pressure were periodically measured. Selected serum and urine biochemical parameters reflecting metabolic and homeostatic changes after Fresubin intake were investigated as well. Heart and kidney weight, diameter of cardiomyocytes, diameter and length of cardiomyocyte nuclei, wall thickness of thoracic aorta, the diameter and the area of renal corpuscles and serum and urine biochemical parameters were assessed at the end of experiment. We showed that Fresubin intake differently affects the investigated morphological and biochemical parameters in rats and this effect was dependent on the developmental stage when Fresubin was provided. Importantly, we have shown that Fresubin-induced elevation of blood pressure is a reversible phenomenon and it is independent of weight gain and subsequent development of obesity.
authors.affiliation: Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic. boris.mravec@fmed.uniba.sk.
authors.forename: Livia
authors.initials: L
authors.lastname: Mikuska
authors.forename: Michaela
authors.initials: M
authors.lastname: Vrabcova
authors.forename: Lubica
authors.initials: L
authors.lastname: Horvathova
authors.forename: Jana
authors.initials: J
authors.lastname: Osacka
authors.forename: Ivan
authors.initials: I
authors.lastname: Varga
authors.forename: Boris
authors.initials: B
authors.lastname: Mravec
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D049628:Body Size / Q000502:physiology; D004044:Dietary Proteins / Q000008:administration & dosage / Q000378:metabolism*; D004326:Drinking / Q000502:physiology; D006321:Heart / Q000502:physiology*; D007668:Kidney / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008297:Male; D009929:Organ Size / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004044:Dietary Proteins; C048418:Fresubin; D008055:Lipids