title: High-definition optical coherence tomography - an aid to clinical practice and research in dermatology.
abstract: At present, beyond clinical assessment, the diagnosis of skin diseases is primarily made histologically. However, skin biopsies have many disadvantages, including pain, scarring, risk of infection, and sampling error. With recent advances in skin imaging technology, the clinical use of imaging methods for the practical management of skin diseases has become an option. The in vivo high-definition optical coherence tomography (HD-OCT) has recently been developed and commercialized (Skintell; Agfa, Belgium). Compared with conventional OCT, it has a higher resolution; compared with reflectance confocal microscopy, it has a shorter time for image acquisition as well as a greater penetration depth and a larger field of view. HD-OCT is promising but much work is still required to develop it from a research tool to a valuable adjunct for the noninvasive diagnosis of skin lesions. Substantial work has been done to identify HD-OCT features in various diseases but interpretation can be time-consuming and tedious. Projects aimed at automating these processes and improving image quality are currently under way.
authors.affiliation: National Skin Centre, Singapore.
authors.forename: Taige
authors.initials: T
authors.lastname: Cao
authors.affiliation: National Skin Centre, Singapore.
authors.forename: Hong Liang
authors.initials: HL
authors.lastname: Tey
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*