title: A person-centered intervention targeting the psychosocial needs of gynecological cancer survivors: a randomized clinical trial.
abstract: We investigated the effect of a person-centered intervention consisting of two to four nurse-led conversations using guided self-determination tailored to gynecologic cancer (GSD-GYN-C) on gynecological cancer survivors' quality of life (QOL), impact of cancer, distress, anxiety, depression, self-esteem, and self-reported ability to monitor and respond to symptoms of recurrence.
  
  
  
  We randomly assigned 165 gynecological cancer survivors to usual care (UC) plus GSD-GYN-C or UC alone. Self-reported QOL-cancer survivor (QOL-CS) total score and subscale scores on physical, psychological, social, and spiritual well-being were assessed before randomization and at 3 and 9 months after randomization using t tests. Bonferroni and Pipper corrections were applied for multiple testing adjustments.
  
  
  
  At 9 months, the GSD-GYN-C plus UC group scored significantly higher on the QOL-CS total scale (P = 0.02) and on the QOL-CS physical well-being subscale (P = 0.01), compared to women receiving UC alone. After adjusting for baseline scores, only the difference in the physical well-being subscale was statistically significant. No other measured outcomes differed between the intervention and control groups after baseline adjustment.
  
  
  
  We observed higher physical well-being 9 months after randomization in the GSD-GYN-C group, as compared to women receiving usual care.
  
  
  
  The results suggest that the person-centered intervention GSD-GYN-C may improve physical well-being in gynecological cancer survivors. However, further testing is needed.
authors.affiliation: Women's and Children's Health Research Unit, Juliane Marie Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark. mette.linnet.olesen@regionh.dk.
authors.forename: Mette Linnet
authors.initials: ML
authors.lastname: Olesen
authors.affiliation: The Danish Cancer Society Research Centre, Copenhagen, Denmark.
authors.forename: Anne-Katrine
authors.initials: AK
authors.lastname: Duun-Henriksen
authors.affiliation: Women's and Children's Health Research Unit, Juliane Marie Centre, Copenhagen, Denmark.
authors.forename: Helena
authors.initials: H
authors.lastname: Hansson
authors.affiliation: Juliane Marie Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Bent
authors.initials: B
authors.lastname: Ottesen
authors.affiliation: Statistics, Bioinformatics and Registry, The Danish Cancer Society Research Centre, Copenhagen, Denmark.
authors.forename: Klaus Kaae
authors.initials: KK
authors.lastname: Andersen
authors.affiliation: Women's and Children's Health Research Unit, Juliane Marie Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark.
authors.forename: Vibeke
authors.initials: V
authors.lastname: Zoffmann
mesh_terms: D000328:Adult; D001007:Anxiety / Q000517:prevention & control; D016022:Case-Control Studies; D003863:Depression / Q000517:prevention & control; D018479:Early Intervention, Educational; D005260:Female; D005833:Genital Neoplasms, Female / Q000523:psychology* / Q000534:rehabilitation*; D006301:Health Services Needs and Demand; D006801:Humans; D001523:Mental Disorders / Q000517:prevention & control; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D018802:Patient-Centered Care / Q000379:methods*; D011788:Quality of Life; D012649:Self Concept; D017741:Survivors / Q000523:psychology*
keywords: Cancer survivorship; Empowerment; Guided Self-Determination; Gynecological cancer; Quality of life; Randomized clinical trial