title: Molecular epidemiology of coxsackievirus B3 infection in Spain, 2004-2014.
abstract: Epidemiological and clinical characteristics of coxsackievirus B3 infections in Spain were investigated. This enterovirus (EV) type was detected mainly in young children (<6 months) and was associated with neurological (78 %) and respiratory diseases (10 %) but also with myo/pericarditis (10 %). Two myocarditis cases were fatal. Phylogenetic analysis of the VP1 region showed that genotype III circulated in the country between 2004 and 2008 and was replaced by genotype V in 2010. Furthermore, phylogenetic analysis of the 3D region indicated that recombination events have occurred and contributed to the genetic evolution of this EV type.
authors.affiliation: Enterovirus Unit, National Centre for Microbiology, National Health Institute "Carlos III", Ctra. Majadahonda-Pozuelo km 2, Madrid, Spain.
authors.forename: Katherine I
authors.initials: KI
authors.lastname: Calderón
authors.affiliation: Enterovirus Unit, National Centre for Microbiology, National Health Institute "Carlos III", Ctra. Majadahonda-Pozuelo km 2, Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Díaz-de Cerio
authors.affiliation: Enterovirus Unit, National Centre for Microbiology, National Health Institute "Carlos III", Ctra. Majadahonda-Pozuelo km 2, Madrid, Spain.
authors.forename: Almudena
authors.initials: A
authors.lastname: Otero
authors.affiliation: Hospital San Joan de Déu, Barcelona, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Muñoz-Almagro
authors.affiliation: Hospital de la Santa Creu I Sant Pau, Barcelona, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Rabella
authors.affiliation: Hospital de Cruces, Bilbao, Spain.
authors.forename: Inés
authors.initials: I
authors.lastname: Martínez-Rienda
authors.affiliation: Hospital Virgen de la Arrixaca, Murcia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Moreno-Docón
authors.affiliation: Enterovirus Unit, National Centre for Microbiology, National Health Institute "Carlos III", Ctra. Majadahonda-Pozuelo km 2, Madrid, Spain.
authors.forename: Gloria
authors.initials: G
authors.lastname: Trallero
authors.affiliation: Enterovirus Unit, National Centre for Microbiology, National Health Institute "Carlos III", Ctra. Majadahonda-Pozuelo km 2, Madrid, Spain. mcabrerizo@isciii.es.
authors.forename: María
authors.identifier: http://orcid.org/0000-0001-7054-5696
authors.initials: M
authors.lastname: Cabrerizo
mesh_terms: D003384:Coxsackievirus Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D029822:Enterovirus B, Human / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D017720:Molecular Epidemiology; D010802:Phylogeny; D013030:Spain / Q000453:epidemiology