title: Zebrafish Reel in Phenotypic Suppressors of Autism.
abstract: Chemical genetics can help decipher novel pathways underlying neurodevelopmental psychiatric impairments. Hoffman et al. (2016) utilized behavioral profiling of psychoactive compounds in zebrafish and identified estrogens as suppressors of a phenotype resulting from loss of an autism risk gene.
authors.affiliation: Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Jakob
authors.initials: J
authors.lastname: Biran
authors.affiliation: Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: gil.levkowitz@weizmann.ac.il.
authors.forename: Gil
authors.initials: G
authors.lastname: Levkowitz
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000188:drug therapy*; D004967:Estrogens / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*
chemical_list: D004967:Estrogens; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins