title: Plasma Levels of Inflammatory Biomarkers in Peripheral Arterial Disease: Results of a Cohort Study.
abstract: Previous research analyzed the level of plasma inflammatory markers in patients with coronary disease, but very few studies have evaluated these markers in patients with peripheral arterial disease (PAD). The objective of this study was to investigate the plasma levels of inflammatory markers in patients with PAD and in healthy controls. The following plasma levels of biomarkers were measured in 80 patients with PAD (mean age 68 ± 5 years) and in 72 healthy participants (mean age 67 ± 6 years): interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), L-selectin (LS), neopterin (N), P-selectin (PS), E-selectin (ES), vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and matrix metalloproteinase 2 (MMP-2), and 9 (MMP-9). Significantly higher levels of IL-6 (P < .001), TNF-α (P < .0001), ES (P < .0001), LS (P < .0001), PS (P < .0001), ICAM-1 (P < .001), VCAM-1 (P < .001), N (P < .001), MMP-2 (P < .001), and MMP-9 (P < .005) were found in the patients with PAD. Patients with PAD show a inflammation marker profile different from that of control participants. Reducing the high plasma levels of inflammatory markers could be a new therapeutic approach both for the prevention and the treatment of PAD.
authors.affiliation: Department of Clinical and Experimental Medicine, Medical Angiology Unit, School of Medicine, University of Catania, Catania, Italy ssignore@unict.it.
authors.forename: Salvatore Santo
authors.initials: SS
authors.lastname: Signorelli
authors.affiliation: Department of Clinical and Experimental Medicine, Medical Angiology Unit, School of Medicine, University of Catania, Catania, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Anzaldi
authors.affiliation: Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Libra
authors.affiliation: Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Navolanic
authors.affiliation: Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy.
authors.forename: Graziella
authors.initials: G
authors.lastname: Malaponte
authors.affiliation: Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy.
authors.forename: Katia
authors.initials: K
authors.lastname: Mangano
authors.affiliation: Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Quattrocchi
authors.affiliation: Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Marco
authors.affiliation: Department of Clinical and Experimental Medicine, Medical Angiology Unit, School of Medicine, University of Catania, Catania, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Fiore
authors.affiliation: Department of Clinical and Experimental Medicine, Medical Angiology Unit, School of Medicine, University of Catania, Catania, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Neri
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000175:diagnosis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
keywords: atherosclerosis; biomarkers; inflammation; peripheral arterial disease