title: THE ROLE OF VIRAL HEPATITIS IN THE MECHANISM OF LIVER CANCER FORMATION AMONG THE FAR NORTH INDIGENOUS INHABITANTS.
abstract: BACKGROUND
  Yakutia is a region of high prevalence of viral hepatitis B, C and D. The rating and ranking of risk factors for the formation of cirrhosis and primary liver cancer in patients with chronic viral hepatitis (CVH) B, C and D in the Republic of Sakha (Yakutia) (R S(Y)), it is a serious medical problem.
  
  
  OBJECTIVE
  Studying of the main reasons for the progression of chronic viral hepatitis B, C and D to cirrhosis and liver cancer in the Far North.
  
  
  METHODS
  Materials of official statistics of theTerritorial Rospotrebnadzor and official registration of the Ministry of Health of RS (Y); serological and molecular biological research methods to the studying of HCV genotype B, C, D.
  
  
  RESULTS
  On the basis of long-term morbidity of chronic viral hepatitis B, C and D and their outcomes in Yakutia defined a role in the progression to cirrhosis and primary liver cancer, ethnicity and genotype of HBV and HDV. Established fact of viral replication in cirrhosis and primary liver cancer under adverse social and environmental factors, genetically determined increased concentration of acetaldehyde due to impaired activity of alcohol dehydrogenases (ADH) and aldegiddegirogenases (AIDG) at the indigenous inhabitants of the republic proves the need for targeted therapy of complex events.
  
  
  CONCLUSIONS
  The regions of Yakutia are the most affected by the virus of hepatitis B, C and D with progressive course of the disease to cirrhosis and cirrhosis liver cancer, defined by genotype hepatitis B & D, in which significantly usually occurs primary liver cancer, also noted that the combined mixed-replicating virus hepatitis is a risk factor for primary liver cancer.
authors.forename: S S
authors.initials: SS
authors.lastname: Sleptsova
authors.forename: N V
authors.initials: NV
authors.lastname: Borisova
mesh_terms: D001110:Arctic Regions / Q000453:epidemiology / Q000208:ethnology; D044466:Asian People; D015897:Comorbidity; D005260:Female; D006521:Hepatitis, Chronic / Q000150:complications* / Q000453:epidemiology / Q000208:ethnology / Q000503:physiopathology*; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology* / Q000503:physiopathology*; D008297:Male; D044382:Population Groups; D015995:Prevalence; D012426:Russia / Q000453:epidemiology / Q000208:ethnology