title: Blast phase transformation of chronic myelogenous leukemia presenting with central nervous system manifestation.
abstract: Chronic myelogenous leukemia (CML) is the most common of all leukemia constituting 15-20% of all leukemia. The clinical course of the diseases runs in two to three phases, initial chronic phase followed by accelerated phase or blast phase. Blast phase most commonly presents clinically as fever, splenomegaly, and bone pain. Here, we present a case of CML in blast phase presenting with central nervous system manifestation in a 55-year-old patient with a brief review of the literature.
authors.affiliation: Department of Pathology, Employees' State Insurance Corporation Medical College and PGIMSR, Bengaluru, Karnataka, India.
authors.forename: Panduranga
authors.initials: P
authors.lastname: Chikkannaiah
authors.affiliation: Department of Pathology, Employees' State Insurance Corporation Medical College and PGIMSR, Bengaluru, Karnataka, India.
authors.forename: Deepak Devlanaik
authors.initials: DD
authors.lastname: Chandranaik
authors.affiliation: Department of Pathology, Employees' State Insurance Corporation Medical College and PGIMSR, Bengaluru, Karnataka, India.
authors.forename: Nagaraj
authors.initials: N
authors.lastname: Erappa
authors.affiliation: Department of Pathology, Employees' State Insurance Corporation Medical College and PGIMSR, Bengaluru, Karnataka, India.
authors.forename: Bharat
authors.initials: B
authors.lastname: Reddy
authors.affiliation: Department of Pathology, Employees' State Insurance Corporation Medical College and PGIMSR, Bengaluru, Karnataka, India.
authors.forename: Srinivasamurthy
authors.initials: S
authors.lastname: Venkataramappa
keywords: Blast phase; cerebral infarct; chronic myeloid leukemia; thrombosis