title: Radiolabeled Nanoparticles for Cancer Diagnosis and Therapy.
abstract: Cancer remains as one of the major causes of death worldwide. The emergence of nanotechnology has opened new avenues for the development of nanoparticle (NP)- based diagnostic and therapeutic tools. NPs of different chemical composition, size, shape and surface decoration can be prepared using a wide variety of synthetic strategies. Subsequent radiolabelling with positron or gamma emitters results in potential diagnostic agents which may offer improved selectivity and/or specificity for the target organ or tissue, enabling the acquisition of images with higher signal-to-contrast ratio. Incorporation of alpha or beta emitters leads to therapeutic agents with application in the field of radiotherapy. Here, we first describe the different labeling strategies reported so far for the incorporation of radionuclides into NPs. Recent advances in the use of nanoparticulate constructs both in the diagnostic and therapeutic arenas are then discussed and examples of their application are briefly discussed.
authors.affiliation: Department of Radiation Physics and Department of Medical and Health Sciences, Linkoping University, Linkoping. Sweden.
authors.forename: Jacek
authors.initials: J
authors.lastname: Koziorowski
authors.affiliation: Department of Carcinogenesis and Molecular Biology, Institute of Oncology "Prof.Dr. Al. Trestioreanu" Bucharest, Bucharest. Romania.
authors.forename: Adina E
authors.initials: AE
authors.lastname: Stanciu
authors.affiliation: Radiochemistry Platform, CIC biomaGUNE, San Sebastian, Guipúzcoa, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gomez-Vallejo
authors.affiliation: Radiochemistry and Nuclear Imaging Group, CIC biomaGUNE, San Sebastian, Guipuzcoa, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Llop
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D019275:Radiopharmaceuticals
keywords: Radiolabelling; cancer diagnosis; nanoparticles; radiometal; therapy