title: Gastric Cancer and Paraneoplastic Pemphigus.
abstract: Paraneoplastic pemphigus is a relatively rare but significant acquired autoimmune mucocutaneous disorder that is characterised by diffuse erythema, painful blistering and sores of the skin and mucus membranes. The underlying pathogenesis is believed to be triggered by altered immune system in response to underlying neoplasm. The manifestations can predate, occur at the same time or after the diagnosis of cancer. Associations with gastric cancer have only been reported twice. A 78-year-old lady presented with a month's history of extensive skin lesions that started off as bullous lesions and biopsy revealed bullous pemphigus. Endoscopy for anemia revealed gastric cancer. This case reinforced the need to consider underlying malignancy in elderly patient with new onset dermatological presentation.
authors.affiliation: Endoscopy Unit, RIPAS Hospital, Bandar Seri Begawan, BA 1710 Brunei.
authors.forename: Norwani
authors.initials: N
authors.lastname: Basir
authors.affiliation: Department of Pathology, RIPAS Hospital, Bandar Seri Begawan, BA 1710 Brunei.
authors.forename: Pemasari Upali
authors.initials: PU
authors.lastname: Telisinghe
authors.affiliation: Endoscopy Unit, RIPAS Hospital, Bandar Seri Begawan, BA 1710 Brunei.
authors.forename: Vui Heng
authors.initials: VH
authors.lastname: Chong
keywords: Bullous dermatological lesions; Gastric cancer; Paraneoplastic manifestations; Pemphigus vulgaris