title: Pre-exposure to fine particulate matters may induce endotoxin tolerance in a mouse model.
abstract: Exposure to low or moderate doses of lipopolysaccharides (LPS) renders the host tolerance to a subsequent lethal dose of LPS, which is termed as endotoxin tolerance. It is characterized as the decrease in production of pro-inflammatory cytokines and the increase in production of anti-inflammatory mediators in response to a second LPS challenge. The alteration of cytokine profile protects LPS-primed hosts against a normally lethal dose of subsequent LPS challenge. Nevertheless, whether other environmental factors also trigger endotoxin tolerance remains unclear. Both epidemiologic and experimental studies have provided a link between particulate matter and human health. Here, we speculated on the effect of fine particles priming on endotoxin tolerance in a mouse model.
authors.affiliation: Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio, USA; Molecular, Cellular, and Developmental Biology program, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Yuntao
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Lu
authors.affiliation: Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio, USA; Molecular, Cellular, and Developmental Biology program, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Sun