title: The Notch meeting: an odyssey from structure to function.
abstract: The Notch signaling pathway plays fundamental roles in diverse developmental processes. Studies of the basic biology of Notch function have provided insights into how its dysfunction contributes to multi-systemic diseases and cancer. In addition, our understanding of Notch signaling in maintaining stem/progenitor cell populations is revealing new avenues for rekindling regeneration. The Notch IX meeting, which was held in Athens, Greece in October 2015, brought together scientists working on different model systems and studying Notch signaling in various contexts. Here, we provide a summary of the key points that were presented at the meeting. Although we focus on the molecular mechanisms that determine Notch signaling and its role in development, we also cover talks describing roles for Notch in adulthood. Together, the talks revealed how interactions between adjacent cells mediated by Notch regulate development and physiology at multiple levels.
authors.affiliation: Section on Neural Developmental Dynamics, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Building 6B, Room 3B-315, Bethesda, MD 20892, USA chitnisa@mail.nih.gov.
authors.forename: Ajay
authors.initials: A
authors.lastname: Chitnis
authors.affiliation: Paris-Saclay Institute for Neuroscience (Neuro-PSI), UMR 9197, CNRS - Université Paris-Sud, Avenue de la Terrasse, Bldg 5, 91190 Gif-sur-Yvette, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Balle-Cuif
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D048430:Cell Shape; D004330:Drosophila / Q000378:metabolism; D006801:Humans; D008024:Ligands; D051379:Mice; D051880:Receptors, Notch / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008024:Ligands; D051880:Receptors, Notch
keywords: Molecular characterization; Structure-function; Systems biology