title: Epidermal Growth Factor Receptor Mutation Status and Treatment Outcome for R0-Resected Patients with Stage 3 Non-small Cell Lung Cancer.
abstract: This study aimed to investigate the association of epidermal growth factor receptor (EGFR) mutation status with treatment outcome for patients with stage 3 non-small cell lung cancer (NSCLC) who had undergone a complete (R0) resection.
  
  
  
  The study identified 3445 NSCLC patients tested for EGFR mutations between September 2001 and December 2011 at the Sun Yat-Sen University Cancer Center. Of these patients, 224 were stage 3 patients who had undergone R0 resections.
  
  
  
  These 224 R0-resected, pathologic stage 3A and 3B patients included 150 patients with wild-type EGFR and 74 patients with EGFR mutations. During a median follow-up period of 42 months (range, 4-133 months), pathologic stage was shown to be the only prognostic factor. The 3-year overall survival (OS) rates did not differ significantly from the OS rates for the wild-type and mutant EGFR groups (62.0 vs 67.2 %; p = 0.789). Multivariate analyses indicated that the patients in the mutant EGFR group with EGFR exon 19 mutations had a better OS rate (73.0 vs 61.1 %; p = 0.026).
  
  
  
  Cancer stage remained the significant prognostic factor in R0-resected stage 3 NSCLC patients. The presence of an EGFR mutation is more likely to be a predictive marker for the response to treatment with tyrosine kinase inhibitors. In the EGFR mutant group, the patients with an exon 19 mutation had better 3-year OS rates. These findings might be considered in future study designs.
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.|Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China.|Guangdong Association Study of Thoracic Oncology, Guangzhou, People's Republic of China.
authors.forename: Song Ran
authors.initials: SR
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.|Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China.|Guangdong Association Study of Thoracic Oncology, Guangzhou, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Qiu
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.|Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.|Guangdong Association Study of Thoracic Oncology, Guangzhou, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.|Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.|Guangdong Association Study of Thoracic Oncology, Guangzhou, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.|Molecular Diagnosis, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.|Guangdong Association Study of Thoracic Oncology, Guangzhou, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.|Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China.|Guangdong Association Study of Thoracic Oncology, Guangzhou, People's Republic of China.
authors.forename: Shi Liang
authors.initials: SL
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.|Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China.|Guangdong Association Study of Thoracic Oncology, Guangzhou, People's Republic of China.
authors.forename: Zhao Lin
authors.initials: ZL
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.|Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.|Guangdong Association Study of Thoracic Oncology, Guangzhou, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.|Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China.|Guangdong Association Study of Thoracic Oncology, Guangzhou, People's Republic of China.
authors.forename: Meng Zhong
authors.initials: MZ
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.|Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.|Guangdong Association Study of Thoracic Oncology, Guangzhou, People's Republic of China.
authors.forename: Si Yu
authors.initials: SY
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.|Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China.|Guangdong Association Study of Thoracic Oncology, Guangzhou, People's Republic of China.
authors.forename: Lan Feng
authors.initials: LF
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China. liuhui@sysucc.org.cn.|Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China. liuhui@sysucc.org.cn.|Guangdong Association Study of Thoracic Oncology, Guangzhou, People's Republic of China. liuhui@sysucc.org.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D011446:Prospective Studies; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C512478:EGFR protein, human; D066246:ErbB Receptors