title: Elevated Serum and Cerebrospinal Fluid Free Fatty Acid Levels Are Associated with Unfavorable Functional Outcome in Subjects with Acute Ischemic Stroke.
abstract: The aim of this study was to evaluate the prognostic value of serum and cerebrospinal fluid (CSF) free fatty acid (FFA) levels in a cohort of patients with an acute ischemic stroke (AIS). In a prospective study, FFA levels were measured using an enzyme cycling method on admission in serum and CSF of 252 consecutive patients with AIS. The prognostic value of FFA to predict the functional outcome and mortality within 90-day was compared with the National Institutes of Health Stroke Scale score and with other known outcome predictors. Serum and CSF levels of FFA increased with increasing severity of stroke as defined by the NIHSS score (all P < 0.001). Patients with an unfavorable outcomes and non-survivors had significantly increased FFA serum and CSF levels on admission (all P < 0.0001). Multivariate logistic regression analysis adjusted for common risk factors showed that serum FFA ≥0.71 mmol/L (third quarters) was an independent predictor of functional outcome (odds ratios (OR) = 4.86; 95 % confidence interval (CI) 2.26-10.48) and mortality (OR = 7.72; 95 % CI 3.01-21.48). The area under the receiver operating characteristic curve of serum FFA was 0.79 (95 % CI, 0.72-0.86) for functional outcome and 0.86 (95 % CI, 0.78-0.94) for mortality. Similarly, CSF FFA level also was an indicator for predicting of functional outcome and mortality. FFA levels in serum and CSF may serve as independent biomarkers in addition of the traditional methods for assessing the functional outcome and mortality of AIS.
authors.affiliation: Department of Anesthesiology, The Affiliated Hospital of Luzhou Medical College, No. 25, Taiping Street, Luzhou, 646000, Sichuan province, People's Republic of China. kingmark76@126.com.
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Duan
authors.affiliation: Department of Electrocardiogram, The Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, China.
authors.forename: Guan-Peng
authors.initials: GP
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, The Affiliated Hospital of Luzhou Medical College, No. 25, Taiping Street, Luzhou, 646000, Sichuan province, People's Republic of China.
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Wang
authors.affiliation: Department of Electrocardiogram, The Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Anesthesiology, The Affiliated Hospital of Luzhou Medical College, No. 25, Taiping Street, Luzhou, 646000, Sichuan province, People's Republic of China.
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Wu
authors.affiliation: Department of Psychiatry, The Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, China.
authors.forename: Ke-Zhi
authors.initials: KZ
authors.lastname: Liu
authors.affiliation: Department of Psychiatry, The Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, The Affiliated Hospital of Luzhou Medical College, No. 25, Taiping Street, Luzhou, 646000, Sichuan province, People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Long
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002545:Brain Ischemia / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging; D015331:Cohort Studies; D005230:Fatty Acids, Nonesterified / Q000097:blood* / Q000134:cerebrospinal fluid*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020127:Recovery of Function / Q000502:physiology; D020521:Stroke / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging
chemical_list: D015415:Biomarkers; D005230:Fatty Acids, Nonesterified
keywords: Acute ischemic stroke; Cerebrospinal fluid; Free fatty acid; Prognostic biomarker; Serum