title: First Presentation of Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome in Pregnancy.
abstract: BACKGROUND
  Reed's syndrome, also known as hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome, is an autosomal dominant condition in which affected individuals may develop cutaneous leiomyomas, uterine fibroids, and renal cell carcinoma.
  
  
  OBJECTIVE
  This report describes a unique case of HLRCC because it presented in pregnancy with development of cutaneous pilar leiomyomas.
  
  
  METHODS
  Review of the literature for previous cases of Reed's syndrome during pregnancy including PubMed and Medline search.
  
  
  RESULTS
  Genetic testing of this patient demonstrated a mutation in the fumarate hydratase (FH) gene. Review of the literature showed only 1 previous case series that described the onset of cutaneous lesions during pregnancy.
  
  
  CONCLUSIONS
  This case serves as a reminder that there may exist a correlation between pregnancy and the first manifestation of cutaneous lesions in patients with HLRCC, and thus an increased clinical suspicion is warranted during this period.
authors.affiliation: University of Ottawa, Ontario, Canada kwool068@uottawa.ca.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Woolner
authors.affiliation: The Ottawa Hospital Civic Campus, Parkdale Clinic, Ottawa, Ontario, Canada.
authors.forename: Ashley
authors.initials: A
authors.lastname: O'Toole
authors.affiliation: The Ottawa Hospital Civic Campus, Parkdale Clinic, Ottawa, Ontario, Canada.
authors.forename: Lauren
authors.initials: L
authors.lastname: LaBerge
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D018231:Leiomyomatosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy
keywords: cancer; dermatology