title: Screening for Pancreatic Cancer in High-risk Populations.
abstract: Pancreatic adenocarcinoma is a leading cause of cancer death. Few patients are candidates for curative resection due to the late stage at diagnosis. While most pancreatic adenocarcinomas are sporadic, approximately 10% have an underlying hereditary basis. Known genetic syndromes account for only 20% of the familial clustering of pancreatic cancer cases. The majority are due to non-syndromic aggregation of pancreatic cancer cases or familial pancreatic cancer. Screening aims to identify high-risk lesions amenable to surgical resection. However, the optimal interval for screening and the management of pancreatic cancer precursor lesions detected on imaging are controversial.
authors.affiliation: Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: Shilpa.Grover@bwh.harvard.edu.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Grover
authors.affiliation: Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Kunal
authors.initials: K
authors.lastname: Jajoo
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000209:etiology; D002277:Carcinoma / Q000000981:diagnostic imaging*; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging* / Q000209:etiology; D049448:Cholangiopancreatography, Magnetic Resonance; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications; D055088:Early Detection of Cancer / Q000379:methods*; D019160:Endosonography; D061325:Hereditary Breast and Ovarian Cancer Syndrome / Q000150:complications; D006801:Humans; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology; D050500:Pancreatitis, Chronic / Q000150:complications; D010580:Peutz-Jeghers Syndrome / Q000150:complications; D012306:Risk
keywords: BRCA; Hereditary; IPMN; Lynch syndrome; PanIN; Pancreatic cancer; Peutz-Jeghers; Screening