title: Keeping homologous recombination in check.
abstract: Pathway choice is a critical event in the repair of DNA double-strand breaks. In a recent paper published in Nature, Orthwein et al. define a mechanism by which homologous recombination is controlled in G1 cells to favor non-homologous end joining.
authors.affiliation: The Francis Crick Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK.
authors.forename: Kasper
authors.initials: K
authors.lastname: Fugger
authors.affiliation: The Francis Crick Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: West
mesh_terms: D016193:G1 Phase; D059765:Homologous Recombination; D006801:Humans