title: Accelerated progression of Hodgkin's-like lymphomas in golli deficient SJL mice.
abstract: Spontaneously occurring lymphomas in SJL mice have many pathological features similar to Hodgkin's lymphoma in humans. The malignant growth of the tumor cells is dependent on the support of host FoxP3(+)CD4(+) regulatory T cells (Tregs). In this study, we report that the ablation of golli protein, a negative regulator of CRAC (calcium release activated calcium) channel, in SJL mice results in an accelerated progression of Hodgkin's-like lymphoma which is accompanied by a facilitated conversion of FoxP3(+) Treg cells. Our results suggest that golli protein might affect the progression of Hodgkin's-like lymphomas through regulating the induction of Treg cells.
authors.affiliation: Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
authors.forename: Suidong
authors.initials: S
authors.lastname: Ouyang
authors.affiliation: Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
authors.forename: Guangming
authors.initials: G
authors.lastname: Han
authors.affiliation: Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
authors.forename: Xiaochu
authors.initials: X
authors.lastname: Wu
authors.affiliation: The Education Ministry Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
authors.forename: Zhengfan
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. Electronic address: jfeng@lsu.edu.
authors.forename: Ji-Ming
authors.initials: JM
authors.lastname: Feng
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism; D018450:Disease Progression; D055786:Gene Knockout Techniques; D006689:Hodgkin Disease / Q000235:genetics / Q000503:physiopathology*; D016753:Interleukin-10 / Q000378:metabolism; D051379:Mice; D004676:Myelin Basic Protein / Q000172:deficiency / Q000235:genetics; D050378:T-Lymphocytes, Regulatory / Q000166:cytology* / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D015220:Calcium Channels; D004676:Myelin Basic Protein; D016753:Interleukin-10
keywords: Foxp3; Golli protein; Hodgkin’s-like lymphoma; Regulatory T cell