title: TAFRO syndrome successfully treated with tocilizumab: A case report and systematic review.
abstract: Thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome is considered as a unique clinicopathologic variant of multicentric Castleman's disease and is recently reported in Japan. This entity represents a severe inflammatory state leading to organ failures such as severe liver dysfunction seen in our case, and can be treated by immunosuppressive agents, steroids, and cyclosporine shown in several case reports. A systematic review and our case suggest the potential utility of tocilizumab as a treatment for TAFRO syndrome.
authors.affiliation: a Department of Haematology/Oncology.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Sakai
authors.affiliation: a Department of Haematology/Oncology.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Maeda
authors.affiliation: b Department of General Medicine.
authors.forename: Akira
authors.initials: A
authors.lastname: Kuriyama
authors.affiliation: c Department of Nephrology , and.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Shimada
authors.affiliation: d Department of Anatomic Pathology , Kurashiki Central Hospital , Kurashiki , Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Notohara
authors.affiliation: a Department of Haematology/Oncology.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ueda
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000627:therapeutic use*; D005871:Castleman Disease / Q000188:drug therapy*; D004487:Edema / Q000188:drug therapy*; D005260:Female; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D013577:Syndrome; D013921:Thrombocytopenia / Q000188:drug therapy*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D007166:Immunosuppressive Agents; C502936:tocilizumab
keywords: Castleman’s disease; Liver injury; Systematic review; Thrombocytopenia; Tocilizumab; anasarca; and organomegaly syndrome; fever; reticulin fibrosis