title: Retinal optical coherence tomography at 1 μm with dynamic focus control and axial motion tracking.
abstract: High-resolution optical coherence tomography (OCT) retinal imaging is important to noninvasively visualize the various retinal structures to aid in better understanding of the pathogenesis of vision-robbing diseases. However, conventional OCT systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking OCT system with automatic focus optimization for high-resolution, extended-focal-range clinical retinal imaging by incorporating a variable-focus liquid lens into the sample arm optics. Retinal layer tracking and selection was performed using a graphics processing unit accelerated processing platform for focus optimization, providing real-time layer-specific en face visualization. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the retina and optic nerve head, from which we extracted clinically relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.
authors.affiliation: Simon Fraser University, Department of Engineering Science, 8888 University Drive, Burnaby, British Columbia V5A1S6, Canada.
authors.forename: Michelle
authors.initials: M
authors.lastname: Cua
authors.affiliation: Simon Fraser University, Department of Engineering Science, 8888 University Drive, Burnaby, British Columbia V5A1S6, Canada.
authors.forename: Sujin
authors.initials: S
authors.lastname: Lee
authors.affiliation: Simon Fraser University, Department of Engineering Science, 8888 University Drive, Burnaby, British Columbia V5A1S6, Canada.
authors.forename: Dongkai
authors.initials: D
authors.lastname: Miao
authors.affiliation: Simon Fraser University, Department of Engineering Science, 8888 University Drive, Burnaby, British Columbia V5A1S6, Canada.
authors.forename: Myeong Jin
authors.initials: MJ
authors.lastname: Ju
authors.affiliation: University of British Columbia, Department of Ophthalmology and Visual Science, Eye Care Center, 2550 Willow Street, Vancouver, British Columbia V5Z 3N9, Canada.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Mackenzie
authors.affiliation: Simon Fraser University, Department of Engineering Science, 8888 University Drive, Burnaby, British Columbia V5A1S6, Canada.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Jian
authors.affiliation: Simon Fraser University, Department of Engineering Science, 8888 University Drive, Burnaby, British Columbia V5A1S6, Canada.
authors.forename: Marinko V
authors.initials: MV
authors.lastname: Sarunic
mesh_terms: D000465:Algorithms; D004867:Equipment Design; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D009898:Optic Disk / Q000033:anatomy & histology*; D012160:Retina / Q000033:anatomy & histology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*