title: Sexual function 1-year after allogeneic hematopoietic stem cell transplantation.
abstract: Treatment with allogeneic hematopoietic stem cell transplantation (HSCT) is associated with short and long-term toxicities that can result in alterations in sexual functioning. The aims of this prospective evaluation were to determine: (1) associations between HSCT and increased sexual dysfunction 1 year after treatment; and (2) associations between sexual dysfunction, body image, anxiety and depression. This controlled prospective cohort study was conducted from October 2010 to November 2013. Patients completed assessments 2-3 weeks before HSCT (N=124) and 1 year after treatment (N=63). Assessment included descriptive data, Sexual Functioning Questionnaire, Body Image Scale and Hospital Anxiety and Depression Scale. The results showed a significant decline in overall sexual function in both men and women (P=<0.001, P=0.010, respectively), although men generally scored higher than women. Forty-seven percent of men and 60% of women reported at least one physical sexual problem 1 year after HSCT. Patients with chronic GVHD trended toward reporting lower levels of sexual function. Finally, women with chronic GVHD scored lower than those without chronic GVHD on the sexual function problem subscale (P=0.008). Sexual dysfunction remains a major problem for men and women 1 year after HSCT and requires routine evaluation and treatment after HSCT.
authors.affiliation: Department of Hematology, Bone Marrow Transplantation Unit, Rigshospitalet University Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: K H
authors.initials: KH
authors.lastname: Noerskov
authors.affiliation: Department of Hematology, Bone Marrow Transplantation Unit, Rigshospitalet University Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: I
authors.initials: I
authors.lastname: Schjødt
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Syrjala
authors.affiliation: The University Hospitals Center for Health Research (UCSF), Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Jarden
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001007:Anxiety; D001828:Body Image; D003863:Depression; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications / Q000523:psychology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012725:Sexual Behavior / Q000523:psychology*; D020018:Sexual Dysfunctions, Psychological / Q000209:etiology*; D011795:Surveys and Questionnaires; D014184:Transplantation, Homologous; D055815:Young Adult