title: Copper(II)-catalyzed C5 and C7 halogenation of quinolines using sodium halides under mild conditions.
abstract: A simple and mild protocol for copper catalyzed halogenation of quinoline at C5 and C7 positions was developed, affording the desired remote C-H activation products in moderate to good yields. This reaction proceeds with low-cost sodium halides (NaX, X = Cl, Br, I) and features excellent substrate tolerance. A series of control experiments were carried out to illustrate a single-electron-transfer process which plays a vital role in the halogenation.
authors.affiliation: College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China. chxyzpf@hotmail.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zhu
authors.forename: Guobin
authors.initials: G
authors.lastname: Zhou
authors.forename: Beibei
authors.initials: B
authors.lastname: Ying
authors.forename: Pingping
authors.initials: P
authors.lastname: Ye
authors.forename: Lingying
authors.initials: L
authors.lastname: Su
authors.forename: Chao
authors.initials: C
authors.lastname: Shen
authors.forename: Pengfei
authors.initials: P
authors.lastname: Zhang