title: Colonoscopy and chromoscopy in hereditary colorectal cancer syndromes.
abstract: With hereditary colorectal cancer prevention studies it is difficult to demonstrate reduced mortality. Large populations are needed with well characterized genetics followed over a long period of time. Those studies do exist for standard white light colonoscopy surveillance in Lynch syndrome, but not for newer technologies including chromoscopy. For these newer technologies adenoma detection rate becomes the stand-in for mortality, and the assumption is made that surveillance efficacy impacts cancer occurrence. Though well-designed and important work exists in this area, the data do not support firm conclusions regarding the use of chromoscopy in Lynch syndrome.
authors.affiliation: Department of Gastroenterology, Creighton University, 2500 California Plaza, Criss II, Room 117A, Omaha, NE, 68178, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Jenkins Wessling
authors.affiliation: Department of Gastroenterology, Creighton University, 2500 California Plaza, Criss II, Room 117A, Omaha, NE, 68178, USA. StephenLanspa@creighton.edu.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lanspa
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000235:genetics; D053705:Capsule Endoscopes; D053704:Capsule Endoscopy; D020685:Colonoscopes; D003113:Colonoscopy / Q000379:methods* / Q000639:trends; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000235:genetics / Q000517:prevention & control; D004396:Coloring Agents / Q000008:administration & dosage*; D055088:Early Detection of Cancer / Q000379:methods* / Q000639:trends; D006801:Humans; D057285:Precision Medicine / Q000379:methods*
chemical_list: D004396:Coloring Agents
keywords: Adenomas; Chromoscopy; Indigo carmine; Lynch syndrome