title: Memory effects of sedative drugs in children and adolescents--protocol for a systematic review.
abstract: BACKGROUND
  Some sedatives used in children and adolescents can affect memory function. Memory impairment of traumatic experience can minimize the chance of future psychological trauma. Knowledge about the potential of different sedatives to produce amnesia can help in the decision-making process of choosing a sedative regimen. The aim of this systematic review is to evaluate the effect of different sedatives on memory of perioperative events in children and adolescents.
  
  
  METHODS
  Electronic databases and other sources, such as trial registers, gray literature, and conference abstracts will be searched. Randomized controlled trials will be included that assess memory of perioperative events in children and adolescents 2-19 years old receiving sedative drugs as premedication or as agents for procedural sedation in a medical or dental settings. The outcomes will be loss of memory after and before sedative administration (anterograde and retrograde amnesia). Two independent reviewers will perform screening, study selection, and data extraction. Disagreement at all levels will be resolved by consensus or by involving a third reviewer. Assessment of the risk of bias of included studies will be performed according to "Cochrane Collaboration's Tool for Assessing Risk of Bias in Randomized Trials." Clinical and methodological heterogeneity across studies will be evaluated to determine if it is possible to combine or not combine study results in a meta-analysis.
  
  
  CONCLUSIONS
  To the best of our knowledge, there is no systematic review that specifically addresses this question. Findings from the review will be useful in the decision-making process about the best sedative for minimizing recall of the medical/dental event and possible psychological trauma.
  
  
  BACKGROUND
  PROSPERO CRD42015017559.
authors.affiliation: Dentistry Graduate Program, Universidade Federal de Goiás (UFG), Primeira Avenida, s/n, esquina com Praça Universitária, Setor Leste Universitário, CEP: 74605-220, Goiânia, GO, Brazil. karollineav@gmail.com.
authors.forename: Karolline A
authors.initials: KA
authors.lastname: Viana
authors.affiliation: Dentistry Graduate Program, Universidade Federal de Goiás (UFG), Primeira Avenida, s/n, esquina com Praça Universitária, Setor Leste Universitário, CEP: 74605-220, Goiânia, GO, Brazil. anelisedaher@terra.com.br.
authors.forename: Anelise
authors.initials: A
authors.lastname: Daher
authors.affiliation: Department of Pediatric Dentistry and Orthodontic, Universidade Federal do Rio de Janeiro, Cidade Universitária, CCS, Rio de Janeiro, 21941-971, RJ, Brazil. rorefa@terra.com.br.
authors.forename: Lucianne C
authors.initials: LC
authors.lastname: Maia
authors.affiliation: Department of Pediatrics, Faculdade de Medicina, UFG, Primeira Avenida, s/n, esquina com Praça Universitária, Setor Leste Universitário, CEP: 74605-220, Goiânia, GO, Brazil. paulosucasas@ufg.br.
authors.forename: Paulo S
authors.initials: PS
authors.lastname: Costa
authors.affiliation: Department of Pediatric Dentistry and Orthodontics, Faculdade de Odontologia, Universidade Federal de Minas Gerais (UFMG), CEP: 31270-901, Belo Horizonte, MG, Brazil. carolcm10@hotmail.com.
authors.forename: Carolina C
authors.initials: CC
authors.lastname: Martins
authors.affiliation: Department of Pediatric Dentistry and Orthodontics, Faculdade de Odontologia, Universidade Federal de Minas Gerais (UFMG), CEP: 31270-901, Belo Horizonte, MG, Brazil. smpaiva@uol.com.br.
authors.forename: Saul M
authors.initials: SM
authors.lastname: Paiva
authors.affiliation: Division of Paediatric Dentistry, Faculdade de Odontologia, UFG, Primeira Avenida, s/n, esquina com Praça Universitária, Setor Leste Universitário, Goiânia, 74605-020, GO, Brazil. lsucasas@ufg.br.
authors.forename: Luciane R
authors.initials: LR
authors.lastname: Costa
mesh_terms: D000293:Adolescent; D000647:Amnesia / Q000139:chemically induced*; D002648:Child; D002675:Child, Preschool; D000066491:Clinical Decision-Making; D016292:Procedural Sedation / Q000379:methods*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects* / Q000627:therapeutic use; D000078202:Systematic Reviews as Topic; D055815:Young Adult
chemical_list: D006993:Hypnotics and Sedatives