title: A randomized, double-blind, placebo controlled, parallel group, efficacy study of alpha BRAIN® administered orally.
abstract: OBJECTIVE
  Alpha BRAIN® is a nootropic supplement that purports to enhance cognitive functioning in healthy adults. The goal of this study was to investigate the efficacy of this self-described cognitive enhancing nootropic on cognitive functioning in a group of healthy adults by utilizing a randomized, double blind, placebo-controlled design.
  
  
  METHODS
  A total of 63-treatment naïve individuals between 18 and 35 years of age completed the randomized, double-blind, placebo controlled trial. All participants completed a 2-week placebo run in before receiving active product, Alpha BRAIN® or new placebo, for 6 weeks. Participants undertook a battery of neuropsychological tests at randomization and at study completion. Primary outcome measures included a battery of neuropsychological tests and measures of sleep.
  
  
  RESULTS
  Compared with placebo, Alpha BRAIN® significantly improved on tasks of delayed verbal recall and executive functioning. Results also indicated significant time-by-group interaction in delayed verbal recall for the Alpha BRAIN® group.
  
  
  CONCLUSIONS
  The use of Alpha BRAIN® for 6 weeks significantly improved recent verbal memory when compared with controls, in a group of healthy adults. While the outcome of the study is encouraging, this is the first randomized controlled trial of Alpha BRAIN®, and the results merit further study.
authors.affiliation: Boston Center for Memory, Newton, MA, USA.|The Memory Clinic, Bennington, VT, USA.|Boston University School of Medicine, Boston, MA, USA.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Solomon
authors.affiliation: Onnit Labs LLC, Austin, TX, USA.
authors.forename: Jarrett
authors.initials: J
authors.lastname: Leech
authors.affiliation: The Memory Clinic, Bennington, VT, USA.
authors.forename: Guy B
authors.initials: GB
authors.lastname: deBros
authors.affiliation: Boston Center for Memory, Newton, MA, USA.|The Memory Clinic, Bennington, VT, USA.
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Murphy
authors.affiliation: Boston Center for Memory, Newton, MA, USA.|Boston University School of Medicine, Boston, MA, USA.
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Budson
authors.affiliation: Boston Center for Memory, Newton, MA, USA.|Boston University School of Medicine, Boston, MA, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Vassey
authors.affiliation: Boston Center for Memory, Newton, MA, USA.|The Memory Clinic, Bennington, VT, USA.|Williams College, Williamstown, MA, USA.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Solomon
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D019587:Dietary Supplements; D004311:Double-Blind Method; D056344:Executive Function; D006801:Humans; D011939:Mental Recall; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000008:administration & dosage*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012890:Sleep; D013067:Speech Perception; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018697:Nootropic Agents; D004364:Pharmaceutical Preparations; C000612389:alpha BRAIN
keywords: cognitive enhancement; nootropic; nutraceutical; randomized controlled trial