title: The Role of Eugenol in the Prevention of Acute Pancreatitis-Induced Acute Kidney Injury: Experimental Study.
abstract: Aim. Acute pancreatitis is an inflammatory intra-abdominal disease, which takes a severe form in 15-20% of patients and can result in high mortality especially when complicated by acute renal failure. The aim of this study is to assess the possible reduction in the extent of acute kidney injury after administration of eugenol in an experimental model of acute pancreatitis. Materials and Methods. 106 male Wistar rats weighing 220-350 g were divided into 3 groups: (1) Sham, with sham surgery; (2) Control, with induction of acute pancreatitis, through ligation of the biliopancreatic duct; and (3) Eugenol, with induction of acute pancreatitis and eugenol administration at a dose of 15 mg/kg. Serum urea and creatinine, histopathological changes, TNF-α, IL-6, and MPO activity in the kidneys were evaluated at predetermined time intervals. Results. The group that was administered eugenol showed milder histopathological changes than the Control group, TNF-α activity was milder in the Eugenol group, and there was no difference in activity for MPO and IL-6. Serum urea and creatinine levels were lower in the Eugenol group than in the Control group. Conclusions. Eugenol administration was protective for the kidneys in an experimental model of acute pancreatitis in rats.
authors.affiliation: Department of Surgery, St. Georges' Hospital, Tooting SW17 0QT, UK.
authors.forename: Charalampos
authors.initials: C
authors.lastname: Markakis
authors.affiliation: Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Tsaroucha
authors.affiliation: Experimental Research Center, ELPEN Pharmaceuticals, Pikermi, 19009 Attica, Greece.
authors.forename: Apostolos E
authors.initials: AE
authors.lastname: Papalois
authors.affiliation: Laboratory of Histology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Lambropoulou
authors.affiliation: Second Propaedeutic Department of Surgery, Thoracic Surgery Department, "Laiko" General Hospital, 11527 Athens, Greece.
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Spartalis
authors.affiliation: Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Tsigalou
authors.affiliation: Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Romanidis
authors.affiliation: Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Simopoulos