title: Biomedical Potential of mTOR Modulation by Nanoparticles.
abstract: Modulation of the mammalian target of rapamycin (mTOR), the principal regulator of cellular homeostasis, underlies the biological effects of engineered nanoparticles, including regulation of cell death/survival and metabolic responses. Understanding the mechanisms and biological actions of nanoparticle-mediated mTOR modulation may help in developing safe and efficient nanotherapeutics to fight human disease.
authors.affiliation: Lady Davis Institute, SMBD Jewish General Hospital and Department of Oncology, McGill University, 546 Pine Avenue West, Montreal, Quebec H2W 1S6, Canada. Electronic address: laura.hulea@mail.mcgill.ca.
authors.forename: Laura
authors.initials: L
authors.lastname: Hulea
authors.affiliation: Vinca Institute of Nuclear Sciences, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia; Polymer Institute, Slovak Academy of Sciences, Dubravska Cesta 9, Bratislava, Slovakia.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Markovic
authors.affiliation: Lady Davis Institute, SMBD Jewish General Hospital and Department of Oncology, McGill University, 546 Pine Avenue West, Montreal, Quebec H2W 1S6, Canada.
authors.forename: Ivan
authors.initials: I
authors.lastname: Topisirovic
authors.affiliation: Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Helmholtzstrasse 20, 89081 Ulm, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Simmet
authors.affiliation: Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Dr. Subotica 1, 11000 Belgrade, Serbia. Electronic address: vtrajkovic@med.bg.ac.rs.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Trajkovic
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D050997:Nanomedicine; D053758:Nanoparticles; D015398:Signal Transduction / Q000187:drug effects; D058570:TOR Serine-Threonine Kinases
chemical_list: C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases
keywords: autophagy; cancer; cell death; mTOR; nanoparticles; oxidative stress