title: Histological and immunohistochemical characterization of feline renal cell carcinoma: a case series.
abstract: Four feline renal cell carcinomas (RCCs) were examined using histopathological and immunohistochemical procedures. Specimens were classified by predominant histological pattern according to WHO criteria. A panel of antibodies including β-catenin, C-KIT, VEGF and VEGF-R2 and double immunostaining for vimentin/cytokeratin and for E-cadherin/CD10 was selected to characterize the tumors. Neoplasms were classified as tubular (3/4) and papillary (1/4). Neoplastic epithelial cells were cytokeratin, vimentin, E-cadherin, VEGF-R2 positive and C-KIT negative; 3 cases were β-catenin positive, whereas only 2 tumors were CD10 and VEGF positive. No correlation with histotype was evident. Our results confirm the low frequency of RCCs in cats and suggest a histological pattern similar to canine RCCs. In contrast, a peculiar immunohistochemical profile different from both canine and human RCCs is identified.
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, 35020, Agripolis, Legnaro (PD), Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Bonsembiante
authors.forename: Silvia Lucia
authors.initials: SL
authors.lastname: Benali
authors.forename: Davide
authors.initials: D
authors.lastname: Trez
authors.forename: Luca
authors.initials: L
authors.lastname: Aresu
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Gelain
mesh_terms: D000818:Animals; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000662:veterinary*; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000473:pathology / Q000662:veterinary*; D008297:Male