title: [The rabbit experimental study for toxicokinetics of chlorpyrifos impacted by hemoperfusion].
abstract: OBJECTIVE
  To investigate toxicokinetic parameters impacted by hemoperfusion after oral chlorpyrifos exposure, to investigate the adsorption effect of hemoperhusion for chlorpyrifos poisoning.
  
  
  METHODS
  12 rabbits were divided into two groups after oral exposure with chlorpyrifos 300 mg/kg body weight. Control group: without hemoperfusion; hemoperfusion group: hemoperfusion starts 0.5 h after chlorpyrifos exposure and lasts for 2h. Blood samples were collected at different times, concentrations of chlorpyrifos were tested by GC, then, toxicokinetic parameterswere calculated and analysis by DAS3.0.
  
  
  RESULTS
  In hemoperfusion group, peak time was (7.19±3.74) h, peak concentrations was (1.37±0.56) mg/L, clearance rate was (13.93±10.27) L/h/kg, apparent volume of distribution was (418.18±147.15) L/kg The difference of these parameter were statistically significant compared with control group (P<0.05).
  
  
  CONCLUSIONS
  Hmoperfusion will decrease the inner exposure and load dose of rabbits with chlorpyrifos poisoning.
authors.affiliation: Shen Zhen Prevention and Treatment Center for Occupational Disease, Shen Zhen 518001, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Guo
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.forename: Hongshun
authors.initials: H
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Long
authors.forename: Qian
authors.initials: Q
authors.lastname: He
authors.forename: Chengye
authors.initials: C
authors.lastname: Sun
authors.forename: Xianqing
authors.initials: X
authors.lastname: Huang
authors.affiliation: E-mail: 13902451399@139.com.
authors.forename: Jian
authors.initials: J
authors.lastname: He
mesh_terms: D000818:Animals; D004390:Chlorpyrifos / Q000493:pharmacokinetics / Q000633:toxicity*; D006464:Hemoperfusion; D008657:Metabolic Clearance Rate; D011817:Rabbits; D066007:Toxicokinetics
chemical_list: D004390:Chlorpyrifos