title: Cost-effectiveness of ranibizumab in the treatment of visual impairment due to diabetic macular edema.
abstract: Objective Ranibizumab, an anti-vascular endothelial growth factor designed for ocular use, has been deemed cost-effective in multiple indications by several Health Technology Assessment bodies. This study assessed the cost-effectiveness of ranibizumab monotherapy or combination therapy (ranibizumab plus laser photocoagulation) compared with laser monotherapy for the treatment of visual impairment due to diabetic macular edema (DME). Methods A Markov model was developed in which patients moved between health states defined by best-corrected visual acuity (BCVA) intervals and an absorbing 'death' state. The population of interest was patients with DME due to type 1 or type 2 diabetes mellitus. Baseline characteristics were based on those of participants in the RESTORE study. Main outputs were costs (in 2013 CA$) and health outcomes (in quality-adjusted life-years [QALYs]) and the incremental cost-effectiveness ratio (ICER) was calculated. This cost-utility analysis was conducted from healthcare system and societal perspectives in Quebec. Results From a healthcare system perspective, the ICERs for ranibizumab monotherapy and combination therapy vs laser monotherapy were CA$24 494 and CA$36 414 per QALY gained, respectively. The incremental costs per year without legal blindness for ranibizumab monotherapy and combination therapy vs laser monotherapy were CA$15 822 and CA$20 616, respectively. Based on the generally accepted Canadian ICER threshold of CA$50 000 per QALY gained, ranibizumab monotherapy and combination therapy were found to be cost-effective compared with laser monotherapy. From a societal perspective, ranibizumab monotherapy and combination therapy provided greater benefits at lower costs than laser monotherapy (ranibizumab therapy dominated laser therapy). Conclusions Ranibizumab monotherapy and combination therapy resulted in increased quality-adjusted survival and time without legal blindness and lower costs from a societal perspective compared with laser monotherapy.
authors.affiliation: a Optum , Burlington , ON , Canada ;
authors.forename: Jennifer
authors.initials: J
authors.lastname: Haig
authors.affiliation: b Novartis Pharmaceuticals Canada Inc. , Dorval , QC , Canada ;
authors.forename: Martin
authors.initials: M
authors.lastname: Barbeau
authors.affiliation: c Novartis Pharma AG , Basel , Switzerland.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ferreira
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000191:economics* / Q000627:therapeutic use; D002170:Canada; D003131:Combined Modality Therapy; D017281:Cost of Illness; D003362:Cost-Benefit Analysis; D048909:Diabetes Complications / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006296:Health Services / Q000191:economics / Q000706:statistics & numerical data; D006801:Humans; D017075:Laser Coagulation / Q000191:economics* / Q000379:methods; D008269:Macular Edema / Q000188:drug therapy* / Q000191:economics / Q000601:surgery; D008297:Male; D008390:Markov Chains; D008875:Middle Aged; D019057:Quality-Adjusted Life Years; D011792:Quebec; D000069579:Ranibizumab / Q000191:economics* / Q000627:therapeutic use; D014792:Visual Acuity
chemical_list: D020533:Angiogenesis Inhibitors; D000069579:Ranibizumab
keywords: Cost-effectiveness analysis; Diabetic retinopathy; Markov process; Ranibizumab