title: TRIMming p53's anticancer activity.
abstract: Several TRIM proteins control abundance and activity of p53. Along this route, TRIM proteins have a serious impact on carcinogenesis and prognosis for cancer patients. In the past years, a significant increase has been made in our understanding of how the TRIM protein family controls p53 activity.
authors.affiliation: Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.|Human Physiology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
authors.forename: S
authors.initials: S
authors.lastname: Elabd
authors.affiliation: Department of Life Sciences, University of Trieste, Trieste, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Meroni
authors.affiliation: Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Blattner
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004249:DNA Damage; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000071156:Promyelocytic Leukemia Protein / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D008565:Membrane Proteins; D000071156:Promyelocytic Leukemia Protein; C114030:TRAT1 protein, human; D016159:Tumor Suppressor Protein p53; D051736:Proto-Oncogene Proteins c-mdm2