title: Combining QMRA and Epidemiology to Estimate Campylobacteriosis Incidence.
abstract: The disease burden of pathogens as estimated by QMRA (quantitative microbial risk assessment) and EA (epidemiological analysis) often differs considerably. This is an unsatisfactory situation for policymakers and scientists. We explored methods to obtain a unified estimate using campylobacteriosis in the Netherlands as an example, where previous work resulted in estimates of 4.9 million (QMRA) and 90,600 (EA) cases per year. Using the maximum likelihood approach and considering EA the gold standard, the QMRA model could produce the original EA estimate by adjusting mainly the dose-infection relationship. Considering QMRA the gold standard, the EA model could produce the original QMRA estimate by adjusting mainly the probability that a gastroenteritis case is caused by Campylobacter. A joint analysis of QMRA and EA data and models assuming identical outcomes, using a frequentist or Bayesian approach (using vague priors), resulted in estimates of 102,000 or 123,000 campylobacteriosis cases per year, respectively. These were close to the original EA estimate, and this will be related to the dissimilarity in data availability. The Bayesian approach further showed that attenuating the condition of equal outcomes immediately resulted in very different estimates of the number of campylobacteriosis cases per year and that using more informative priors had little effect on the results. In conclusion, EA was dominant in estimating the burden of campylobacteriosis in the Netherlands. However, it must be noted that only statistical uncertainties were taken into account here. Taking all, usually difficult to quantify, uncertainties into account might lead to a different conclusion.
authors.affiliation: Centre for Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
authors.forename: Eric G
authors.initials: EG
authors.lastname: Evers
authors.affiliation: Centre for Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
authors.forename: Martijn
authors.initials: M
authors.lastname: Bouwknegt
mesh_terms: D001499:Bayes Theorem; D002138:Calibration; D002167:Campylobacter; D002169:Campylobacter Infections / Q000175:diagnosis* / Q000453:epidemiology*; D016022:Case-Control Studies; D005759:Gastroenteritis; D006801:Humans; D015994:Incidence; D016013:Likelihood Functions; D009010:Monte Carlo Method; D009426:Netherlands / Q000453:epidemiology; D016012:Poisson Distribution; D011336:Probability; D011446:Prospective Studies; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*
keywords: Campylobacter; QMRA; disease burden; epidemiology