title: Natural history of pessary use in women aged 65 - 74 versus 75 years and older with pelvic organ prolapse: a 12-year study.
abstract: OBJECTIVE
  The feasibility of use and long-term outcomes of vaginal pessaries for the management of pelvic organ prolapse (POP) in older women remains unknown. Our aim was to determine successful fit rates and outcomes among older women seeking care for POP.
  
  
  METHODS
  This was a retrospective cohort study of 304 consecutive women aged 65 years and older with symptomatic POP undergoing a pessary trial at the outpatient urogynecology clinic in Québec, Canada. Women successfully fitted with a pessary were followed, and survival curves were used to ascertain the median time to pessary discontinuation for women aged 65 to 74 years in comparison with women aged 75 years and older. Long-term use was defined as longer than 1 year. Predictors of a successful fitting and long-term discontinuation were ascertained using logistic and Cox regression analyses.
  
  
  RESULTS
  Half of the women attempting a pessary trial were aged 75 years and older, and 63 % were fitted successfully regardless of age. Women with a history of hysterectomy or reconstructive pelvic surgery, or those with posterior vaginal wall prolapse were more likely to fail initial insertion. For women aged 65 to 74 years and women aged 75 years and older, the cumulative probabilities of continued pessary use were 87.5 % and 80.8 % at 1 year, 80.6 % and 70.9 % at 2 years, and 62.1 % versus 37.8 % at 5 years. Erosions occurred in 19.3 % of long-term users, with women aged 75 years and older more likely to experience vaginal erosions (HR 3.2, 95 % CI 1.6 - 6.3) and discontinue pessary use.
  
  
  CONCLUSIONS
  Pessary use is a feasible and acceptable treatment option for the long-term management of symptomatic prolapse in over 60 % of all women aged 65 years and older.
authors.affiliation: Centre hospitalier universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé de l'Université de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Sophie
authors.initials: S
authors.lastname: Ramsay
authors.affiliation: Centre hospitalier universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé de l'Université de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Le Mai
authors.initials: le M
authors.lastname: Tu
authors.affiliation: Centre de Recherche de l'Institut universitaire de gériatrie de Montréal, Faculty of Medicine, Université de Montréal, 4545 Queen Mary Road, Montreal, QC, Canada, H3W1W5. cara.tannenbaum@umontreal.ca.
authors.forename: Cara
authors.initials: C
authors.lastname: Tannenbaum
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D009864:Ontario; D010349:Patient Compliance; D056887:Pelvic Organ Prolapse / Q000628:therapy*; D010570:Pessaries / Q000706:statistics & numerical data*; D016016:Proportional Hazards Models; D013997:Time Factors; D016896:Treatment Outcome
keywords: Discontinuation; Elderly women; Pelvic organ prolapse; Pessary