title: Effect of Topical Application of the Cream Containing Magnesium 2% on Treatment of Diaper Dermatitis and Diaper Rash in Children A Clinical Trial Study.
abstract: BACKGROUND
  Diaper dermatitis is referred to the inflammation in outer layers of the skin in the perineal area, lower abdomen, and inner thighs. The lesions are maculopapular and usually itchy, which could cause bacterial or candida infection, and predispose the infants to penis or vaginal and urinary infection and lead to discomfort, irritability, and restlessness. The drugs which have been so far administered for this disease (topical steroids) cause special complications for the sensitive skin in this area. Magnesium (Mg) is known for its anti-inflammatory and wound-healing properties.
  
  
  OBJECTIVE
  The aim of the present study was to study the effect of the cream containing Mg 2% on treatment of diaper dermatitis and diaper rash in children.
  
  
  METHODS
  In this clinical trial study, 64 children aged less than two years old with diaper dermatitis referring Paediatric Ward of Hajar Hospital were randomly assigned to two groups of 32. Group one was treated with the combined cream Mg 2% and Calendula and group two with Calendula cream alone. The duration of recovery was compared between the two groups.
  
  
  RESULTS
  The duration of recovery was significantly lower in the intervention group than the control group (p-value<0.001), but there was no significant difference in the lesions size and diapers' number between the two groups.
  
  
  CONCLUSIONS
  Based on the finding of this study, Mg is effective on treatment of diaper dermatitis and could be used for treating diaper dermatitis and other types of dermatitis.
authors.affiliation: Assistant Professor, Department of Pediatrics, Tehran University of Medical Sciences , Shahrekord, Iran .
authors.forename: Seyyed Mohammad-Kazem
authors.initials: SM
authors.lastname: Nourbakhsh
authors.affiliation: Student, Student Research Committee, Department of Medicinal Plants, Medical Plants Research Center, Shahrekord University of Medical Sciences , Shahrekord, Iran .
authors.forename: Hojjatollah
authors.initials: H
authors.lastname: Rouhi-Boroujeni
authors.affiliation: Community Medicine, Department of Biostatistics, Isfahan University of Medical Sciences , Isfahan, Iran .
authors.forename: Maryam
authors.initials: M
authors.lastname: Kheiri
authors.affiliation: Associate Professor, Department of Epidemiology and Biostatistics, Shahrekord University of Medical Sciences , Shahrekord, Iran .
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Mobasheri
authors.affiliation: Assistant Professor, Department of Surgery, Shahrekord University of Medical Sciences , Shahrekord, Iran .
authors.forename: Majid
authors.initials: M
authors.lastname: Shirani
authors.affiliation: Pediatrician, Department of Pediatrics, Sabzevar University of Medical Sciences , Sabzevar, Iran .
authors.forename: Saeedeh
authors.initials: S
authors.lastname: Ahrani
authors.affiliation: General Practitioner, Department of Pediatrics, Shahrekord University of Medical Sciences , Shahrekord, Iran .
authors.forename: Javad
authors.initials: J
authors.lastname: Karami
authors.affiliation: Research Expert, Department of Nursing, Research and Technology Division, Shahrekord University of Medical Sciences , Shahrekord, Iran .
authors.forename: Zahra Keivani
authors.initials: ZK
authors.lastname: Hafshejani
keywords: Calendula; Inflammation; Ointment