title: Uncommon secondary metabolites from Etlingera pavieana rhizomes.
abstract: From the rhizomes of Etlingera pavieana (Pierre ex Gagnep.) R.M. Sm., four phenylpropens, (E)-3-(4-methoxyphenyl)prop-2-en-1-amine (1), (E)-4-methoxycinamaldehyde (2), (E)-4-methoxycinamic acid (3) and (E)-1-methoxy-4-(3-methoxyprop-1-enyl)benzene (4), together with two other compounds, (E)-((E)-3-(4-methoxyphenyl)allyl)3-(4-hydroxyphenyl)acrylate (5) and 4-methoxybenzoic acid (6) were isolated. This is the first report on the presence of all compounds in Etlingera. Compounds 1 and 5 have been previously synthesised, but this is the first report of their isolation from a natural source. Compound 5 exhibited weak activity against Mycobacterium tuberculosis with MIC 50.00 μg/mL and cytotoxic activity against the KB, MCF7 and NCI-H187 cells with IC50 values of 25.11, 20.16 and 34.83 μg/mL, respectively.
authors.affiliation: a Faculty of Science, Department of Chemistry and Centre for Innovation in Chemistry , Chiang Mai University , Chiang Mai , Thailand.
authors.forename: Sirichan
authors.initials: S
authors.lastname: Tachai
authors.affiliation: a Faculty of Science, Department of Chemistry and Centre for Innovation in Chemistry , Chiang Mai University , Chiang Mai , Thailand.
authors.forename: Nuchnipa
authors.initials: N
authors.lastname: Nuntawong
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D027343:Rhizome / Q000378:metabolism*; D030521:Zingiberaceae / Q000378:metabolism*
chemical_list: D000972:Antineoplastic Agents, Phytogenic
keywords: (E)-((E)-3-(4-methoxyphenyl)allyl)3-(4-hydroxyphenyl)acrylate; (E)-3-(4-methoxyphenyl)prop-2-en-1-amine; Etlingera pavieana; Zingiberaceae; cytotoxic activity