title: Accelerated Onset of Action and Increased Tolerability in Treating Acne With a Fixed-Dose Combination Gel.
abstract: Nonadherence to topical acne therapies is a major contributing factor to poor treatment outcomes. Multiple contributing factors have been identified, including a lack of perceived efficacy and fear of side effects. A fixed-dose combination gel of adapalene/benzoyl peroxide gel, 0.1%/2.5% (A-BPO) is an efficacious and safe treatment for a range of acne severities in patients as young as 9 years old. A meta-analysis of 14 clinical studies involving A-BPO was conducted to assess the 4 week efficacy and overall tolerability of this treatment. Over 2,300 subjects were included in the analysis. Mean total, inflammatory, and non-inflammatory lesion counts decreased at 4 weeks by 40.8%, 46.2%, and 37.5%, respectively. Worst post-baseline tolerability scores for stinging/burning, dryness, scaling, and erythema were none or mild for a majority of subjects. The result of this meta-analysis add to the body of literature supporting the use of A-BPO in a variety of acne patients and shows that A-BPO provides meaningful clinical results within 4 weeks and will be well-tolerated for a majority of patients. With a demonstrable quick onset of action and high tolerability, A-BPO may improve adherence, and ultimately treatment outcomes, by addressing factors that contribute to nonadherence.
authors.forename: Adam
authors.initials: A
authors.lastname: Friedman
authors.forename: Kim
authors.initials: K
authors.lastname: Waite
authors.forename: Staci
authors.initials: S
authors.lastname: Brandt
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Meckfessel
mesh_terms: D000152:Acne Vulgaris / Q000175:diagnosis* / Q000188:drug therapy*; D000068801:Adapalene, Benzoyl Peroxide Drug Combination / Q000008:administration & dosage* / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D002648:Child; D002986:Clinical Trials as Topic / Q000379:methods; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004338:Drug Combinations; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000068801:Adapalene, Benzoyl Peroxide Drug Combination; D003879:Dermatologic Agents; D004338:Drug Combinations; D005782:Gels