title: Intracytoplasmic sperm injection (ICSI) outcomes of azoospermia with different causes: 107 cases report.
abstract: This retrospective analysis compared the outcomes of fertilization and pregnancy rates of 107 azoospermia patients treating with intracytoplasmic sperm injection (ICSI). Sperms were obtained by testicular biopsy surgery, with which we used in ICSI subsequently. The outcomes were compared by different kinds of causes leading to azoospermia in the 107 cases. 69 cases of obstructive azoospermia and 38 cases non-obstructive, the fertilization rates were 61.94% and 53.47% respectively, and pregnancy rates were 67.65% and 52.63%. 78 cases with normal volume testes and 29 cases with small testes, the fertilization rates were 70.93% and 48.80% respectively, and pregnancy rates were 66.25% and 50.00%. There was significant difference in fertilization rates between obstructive, non-obstructive and normal volume testes, small testes (P < 0.05), but no significant difference in pregnancy rates (P > 0.05). The pregnancy rate was significant difference between female age < 32 and ≥ 32 whatever the cause of azoospermia was (P < 0.05). Our study reveals that obstructive azoospermia and normal volume testes have higher fertilization rates in ICSI, but the pregnancy rates are only related to female age.
authors.affiliation: Department of Andrology, The 2nd Teaching Hospital, Chengdu University of Traditional Chinese Medicine Chengdu 610041, Sichuan, China.
authors.forename: Xu-Jun
authors.initials: XJ
authors.lastname: Yu
authors.affiliation: Chengdu University of Traditional Chinese Medicine Chengdu 610072, Sichuan, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Dong
authors.affiliation: Chengdu University of Traditional Chinese Medicine Chengdu 610072, Sichuan, China.
authors.forename: Fei-Qiang
authors.initials: FQ
authors.lastname: Ren
authors.affiliation: Chengdu University of Traditional Chinese Medicine Chengdu 610072, Sichuan, China.
authors.forename: Di-Ang
authors.initials: DA
authors.lastname: Chen
authors.affiliation: Department of Urology and Andrology, Sichuan Integrative Medicine Hospital Chengdu 610041, Sichuan, China.
authors.forename: Pei-Hai
authors.initials: PH
authors.lastname: Zhang
authors.affiliation: Department of Urology and Andrology, The 1st Teaching Hospital, Chengdu University of Traditional Chinese Medicine Chengdu 610072, Sichuan, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Urology and Andrology, The 1st Teaching Hospital, Chengdu University of Traditional Chinese Medicine Chengdu 610072, Sichuan, China.
authors.forename: Yao-Dong
authors.initials: YD
authors.lastname: You
authors.affiliation: Department of Urology and Andrology, The 1st Teaching Hospital, Chengdu University of Traditional Chinese Medicine Chengdu 610072, Sichuan, China.
authors.forename: Guang-Sen
authors.initials: GS
authors.lastname: Li
authors.affiliation: Department of Andrology, The 2nd Teaching Hospital, Chengdu University of Traditional Chinese MedicineChengdu 610041, Sichuan, China; Department of Urology and Andrology, The 1st Teaching Hospital, Chengdu University of Traditional Chinese MedicineChengdu 610072, Sichuan, China.
authors.forename: De-Gui
authors.initials: DG
authors.lastname: Chang
keywords: Azoospermia; ICSI outcomes; different causes; male infertility