title: Multi-azole resistant Aspergillus fumigatus harboring Cyp51A TR46/Y121F/T289A isolated in Japan.
abstract: Multi-azole resistant Aspergillus fumigatus carrying TR46/Y121F/T289A was isolated from a patient in Japan in Dec 2013. This strain grouped into the same clade of the ones which were clinically isolated in France and Germany. A. fumigatus harboring this mutation could be rapidly diffused outside the Eurasian continent.
authors.affiliation: Division of Clinical Research, Medical Mycology Research Center, Chiba University, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hagiwara
authors.affiliation: Division of Bio-resources, Medical Mycology Research Center, Chiba University, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Department of Internal Medicine, Mitsui Memorial Hospital, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Fujimoto
authors.affiliation: Department of Internal Medicine, Mitsui Memorial Hospital, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Sugahara
authors.affiliation: Department of Infection Control and Prevention, The University of Tokyo Hospital, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Misawa
authors.affiliation: Division of Bio-resources, Medical Mycology Research Center, Chiba University, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
authors.affiliation: Department of Infection Control and Prevention, Mitsui Memorial Hospital, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Itoyama
authors.affiliation: Division of Clinical Research, Medical Mycology Research Center, Chiba University, Japan. Electronic address: fewata@faculty.chiba-u.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Watanabe
authors.affiliation: Division of Clinical Research, Medical Mycology Research Center, Chiba University, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kamei
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D001393:Azoles / Q000627:therapeutic use*; D025141:Drug Resistance, Fungal / Q000187:drug effects / Q000235:genetics*; D005260:Female; D005602:France; D005656:Fungal Proteins / Q000235:genetics*; D005858:Germany; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests / Q000379:methods; D009154:Mutation / Q000235:genetics; D065819:Voriconazole / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D005656:Fungal Proteins; D065819:Voriconazole
keywords: Aspergillus fumigatus; Cyp51A; Multiple-antifungal resistance