title: Tumor Suppressor Candidate 1 Suppresses Cell Growth and Predicts Better Survival in Glioblastoma.
abstract: Glioblastoma (GBM) is the most common malignant brain tumor with poor prognosis and limited treatment options. Tumor suppressor candidate 1 (TUSC1) was recently identified as a potential tumor suppressor in human cancers. However, the expression and potential function of TUSC1 in GBM remain unclear. Herein, we report that TUSC1 is significantly decreased in GBM tissues and cell lines. Patients with high levels of TUSC1 displayed a significant better survival compared with those with low levels of TUSC1. Functional experiments demonstrated that exogenous expression of TUSC1 inhibited GBM cell proliferation and induced G1 phase arrest by down-regulating CDK4. Moreover, overexpression of TUSC1 retarded tumor growth in vivo. Together, our findings revealed that TUSC1 might be a crucial tumor suppressor gene and a novel therapeutic target for GBM.
authors.affiliation: Department of Neurosurgery, Nanjing Children's Hospital, Affiliated to Nanjing Medical University, Nanjing, 210029, China.|Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Hospital of Integrated Traditional Chinese and Western Medicine in Jiangsu Province, Nanjing, 210029, China.
authors.forename: Wan
authors.initials: W
authors.lastname: Yu
authors.affiliation: The Institute of Pediatrics, Affiliated to Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Guanyu
authors.initials: G
authors.lastname: Liang
authors.affiliation: Department of Neurosurgery, Nanjing Children's Hospital, Affiliated to Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Zhengxin
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Microbiology & Immunology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Laboratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Daqian
authors.initials: D
authors.lastname: Li
authors.affiliation: The Institute of Biochemistry, Zhejiang University, Hangzhou, 310058, China.
authors.forename: Shuying
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.|Chinese Glioma Cooperative Group (CGCG), Beijing, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.affiliation: The Institute of Pediatrics, Affiliated to Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. hbwang@njmu.edu.cn.|Chinese Glioma Cooperative Group (CGCG), Beijing, China. hbwang@njmu.edu.cn.
authors.forename: Huibo
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Nanjing Children's Hospital, Affiliated to Nanjing Medical University, Nanjing, 210029, China. gwangch@126.com.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000517:prevention & control; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000502:physiology; D005909:Glioblastoma / Q000378:metabolism* / Q000401:mortality / Q000517:prevention & control; D006131:Growth Inhibitors / Q000096:biosynthesis*; D057809:HEK293 Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011237:Predictive Value of Tests; D015996:Survival Rate / Q000639:trends; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis*
chemical_list: D006131:Growth Inhibitors; C000591496:TUSC1 protein, human; D025521:Tumor Suppressor Proteins
keywords: Glioblastoma; Proliferation; TUSC1; Tumor suppressor