title: Three-arm age-matched retrospective cohort study of obstetric outcomes of donor oocyte pregnancies.
abstract: OBJECTIVE
  To evaluate and compare obstetric complications between women who conceived after oocyte donation and age-matched control women who conceived spontaneously or by autologous in vitro fertilization (IVF).
  
  
  METHODS
  In a retrospective cohort study, data were assessed from all women who conceived after oocyte donation and delivered a live neonate after 24weeks of pregnancy between January 2007 and December 2014 at a UK hospital. Two age-matched control groups-one containing women who conceived after autologous IVF and the other containing women who conceived spontaneously-were used for comparison. The primary study outcome was hypertensive disorders of pregnancy (pregnancy-induced hypertension and pre-eclampsia). Multivariate analysis was performed by logistic regression.
  
  
  RESULTS
  Each group included 45 women. Hypertensive disorders in pregnancy affected 15 (33%) women in the study group, 3 (7%) women who conceived after autologous IVF, and 3 (7%) who conceived spontaneously. The risk of hypertensive disorders in pregnancy was significantly higher in the donor oocyte group (odds ratio 5.85, 95% confidence interval 1.42-23.9; P=0.01).
  
  
  CONCLUSIONS
  Women who conceived after oocyte donation had an increased risk of hypertensive disorders. Oocyte donation should be managed as an independent risk factor, and couples should be counselled appropriately.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospitals of Leicester, Leicester, UK. Electronic address: drybjeve@gmail.com.
authors.forename: Yadava B
authors.initials: YB
authors.lastname: Jeve
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospitals of Leicester, Leicester, UK.
authors.forename: Neelam
authors.initials: N
authors.lastname: Potdar
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospitals of Leicester, Leicester, UK.
authors.forename: Albert
authors.initials: A
authors.lastname: Opoku
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospitals of Leicester, Leicester, UK.
authors.forename: Manjiri
authors.initials: M
authors.lastname: Khare
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D005317:Fetal Growth Retardation / Q000453:epidemiology; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology* / Q000209:etiology; D007231:Infant, Newborn; D016015:Logistic Models; D008423:Maternal Age; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D018587:Oocyte Donation / Q000009:adverse effects*; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D047928:Premature Birth / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D006113:United Kingdom
keywords: Donor oocyte; Hypertensive disorder; In vitro fertilization; Intracytoplasmic sperm injection; Obstetric outcome; Pre-eclampsia