title: Binding Potency of Heparin Immobilized on Activated Charcoal for DNA Antibodies.
abstract: In vitro experiments showed that heparin adsorbed on activated charcoal can bind antibodies raised against native and single-stranded DNA in a diluted sera pool with a high level of these DNA. Thus, heparin used as anticoagulant during hemosorption procedure can demonstrate supplementary therapeutic activity resulting from its interaction with various agents involved in acute and chronic inflammatory reactions such as DNA- and RNA-binding substances, proinflammatory cytokines, complement components, growth factors, etc. Research and development of heparin-containing carbonic adsorbents for the therapy of numerous inflammatory and autoimmune diseases seems to be a promising avenue in hematology.
authors.affiliation: R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine, Kiev, Ukraine. lisasne@hotmail.com.
authors.forename: E A
authors.initials: EA
authors.lastname: Snezhkova
authors.affiliation: Faculty of Medicine and Pharmacy, University d'Auvergne, Clermont-Ferrand, France.
authors.forename: A
authors.initials: A
authors.lastname: Tridon
authors.affiliation: Faculty of Medicine and Pharmacy, University d'Auvergne, Clermont-Ferrand, France.
authors.forename: B
authors.initials: B
authors.lastname: Evrard
authors.affiliation: R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine, Kiev, Ukraine.
authors.forename: V G
authors.initials: VG
authors.lastname: Nikolaev
authors.affiliation: A. A. Bogomolets National Medical University, Kiev, Ukraine.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Uvarov
authors.affiliation: A. A. Bogomolets National Medical University, Kiev, Ukraine.
authors.forename: R S
authors.initials: RS
authors.lastname: Tsimbalyuk
authors.affiliation: R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine, Kiev, Ukraine.
authors.forename: A A
authors.initials: AA
authors.lastname: Ivanuk
authors.affiliation: Research Institute of Physicochemical Medicine, Federal Medical-Biological Agency, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Komov
authors.affiliation: R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine, Kiev, Ukraine.
authors.forename: L A
authors.initials: LA
authors.lastname: Sakhno
mesh_terms: D000327:Adsorption / Q000502:physiology; D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology* / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000628:therapy; D002606:Charcoal / Q000378:metabolism* / Q000627:therapeutic use; D004277:DNA, Single-Stranded / Q000276:immunology*; D006493:Heparin / Q000378:metabolism* / Q000627:therapeutic use; D011817:Rabbits
chemical_list: D000974:Antibodies, Antinuclear; D000925:Anticoagulants; D004277:DNA, Single-Stranded; D002606:Charcoal; D006493:Heparin
keywords: activated charcoal; anti-DNA antibodies; hemosorption; heparin; heparinbinding substances