title: On the accessibility of surface-bound drugs on magnetic nanoparticles. Encapsulation of drugs loaded on modified dextran-coated superparamagnetic iron oxide by β-cyclodextrin.
abstract: We report the loading of drugs on aminoethylaminodextran-coated iron oxide nanoparticles, their superparamagnetic behavior, loading of drugs on them, and the β-cyclodextrin-complex formation of the drugs on the surface of the nanoparticles. The magnetic behavior is studied using vibrating sample magnetometry and X-ray photoelectron spectroscopy is used to analyze the elemental composition of drug-loaded nanoparticles. Scanning electron microscopy shows ordered structures of drug-loaded nanoparticles. UV-visible absorption and fluorescence spectroscopy are used to study the binding of the surface-loaded drugs to β-cyclodextrin. All of the drugs form 1:1 host-guest complexes. The iodide ion quenching of fluorescence of free- and iron oxide-attached drugs are compared. The binding strengths of the iron oxide surface-loaded drugs-β-cyclodextrin binding are smaller than those of the free drugs.
authors.affiliation: Department of Chemistry, Karunya University, Coimbatore 641 114, Tamil Nadu, India.
authors.forename: Natesan
authors.initials: N
authors.lastname: Sudha
authors.affiliation: Department of Chemistry, Karunya University, Coimbatore 641 114, Tamil Nadu, India. Electronic address: sameen_y@yahoo.co.in.
authors.forename: Sameena
authors.initials: S
authors.lastname: Yousuf
authors.affiliation: Department of Chemistry, Karunya University, Coimbatore 641 114, Tamil Nadu, India; Department of Nanosciences & Technology, Karunya University, Coimbatore 641 114, Tamil Nadu, India. Electronic address: drisraelenoch@gmail.com.
authors.forename: Enoch V M V
authors.initials: EVMV
authors.lastname: Israel
authors.affiliation: Department of Chemistry, Karunya University, Coimbatore 641 114, Tamil Nadu, India.
authors.forename: Mosae Selvakumar
authors.initials: MS
authors.lastname: Paulraj
authors.affiliation: Department of Bioinformatics, Karunya University, Coimbatore 641 114, Tamil Nadu, India.
authors.forename: Premnath
authors.initials: P
authors.lastname: Dhanaraj
mesh_terms: D000069059:Atorvastatin / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry*; D004339:Drug Compounding; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D060306:Magnetometry; D008855:Microscopy, Electron, Scanning; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D020849:Raloxifene Hydrochloride / Q000737:chemistry; D000077385:Silybin; D012838:Silymarin / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013499:Surface Properties; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D003911:Dextrans; D058185:Magnetite Nanoparticles; D004364:Pharmaceutical Preparations; D012838:Silymarin; D047392:beta-Cyclodextrins; D020849:Raloxifene Hydrochloride; D000077385:Silybin; D000069059:Atorvastatin; C065507:ferumoxides; C031215:betadex
keywords: Bovine serum albumin; Iron oxide; Magnetic nanoparticles; β-Cyclodextrin