title: Terpenoids and Steroids from Euphorbia hypericifolia.
abstract: Two new triterpenoids and two new sterols, named euphyperins A-D (1-4), including an oleanane-type triterpenoid (1), a lupane-type nortriterpenoid (2), and two cholestane-type steroids (3 and 4), along with five known compounds (5-9) were isolated from the twigs and leaves of Euphorbia hypericifolia. Euphyperin B (2) represents a rare lupane-type nortriterpenoid, and euphyperin C (3) is a novel 8,14-secocholestane-type steroid. Euphyperin A (1) exhibited moderate PTP1B inhibitory activity with an IC50 = 17.05 ± 1.12 μg/mL.
authors.forename: Jin-Xin
authors.initials: JX
authors.lastname: Zhao
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Shi
authors.forename: Li
authors.initials: L
authors.lastname: Sheng
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D028481:Euphorbia / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013256:Steroids / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry*
chemical_list: D013256:Steroids; D013729:Terpenes