title: A Long-term Survivor after Congenital Acute Myeloid Leukemia with t(8 ; 16)(p11 ; p13).
abstract: The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8 ; 16) (p11 ; p13) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ-CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ-CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ-CBP in the pediatric population might show better prognoses.
authors.affiliation: Department of Pediatrics, Okayama University Hospital, Okayama 700-8558, Japan.
authors.forename: Takae
authors.initials: T
authors.lastname: Hanada
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Kanamitsu
authors.forename: Kosuke
authors.initials: K
authors.lastname: Chayama
authors.forename: Takako
authors.initials: T
authors.lastname: Miyamura
authors.forename: Yui
authors.initials: Y
authors.lastname: Kanazawa
authors.forename: Michiko
authors.initials: M
authors.lastname: Muraoka
authors.forename: Kana
authors.initials: K
authors.lastname: Washio
authors.forename: Masahide
authors.initials: M
authors.lastname: Imada
authors.forename: Misao
authors.initials: M
authors.lastname: Kageyama
authors.forename: Akihito
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Kei
authors.initials: K
authors.lastname: Tamai
authors.forename: Megumi
authors.initials: M
authors.lastname: Oda
authors.forename: Akira
authors.initials: A
authors.lastname: Shimada
mesh_terms: D002885:Chromosomes, Human, Pair 16; D002898:Chromosomes, Human, Pair 8; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000151:congenital* / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D012334:RNA, Neoplasm / Q000032:analysis; D017423:Sequence Analysis, RNA; D017741:Survivors
chemical_list: C470260:MOZ-CBP fusion protein, human; D015514:Oncogene Proteins, Fusion; D012334:RNA, Neoplasm