title: Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain.
abstract: Enhanced neurogenesis has been reported in the hippocampus of patients with Alzheimer's disease (AD), the most common neurodegenerative disorder characterized with amyloid-β (Aβ) aggregation, tau hyperphosphorylation, and progressive neuronal loss. Previously we reported that tau phosphorylation played an essential role in adult hippocampal neurogenesis, and activation of glycogen synthase kinase (GSK-3), a crucial tau kinase, could induce increased hippocampal neurogenesis. In the present study, we found that treatment of D-galactose rats with Puerarin could significantly improve behavioral performance and ameliorate the enhanced neurogenesis and microtubule-associated protein tau hyperphosphorylation in the hippocampus of D-galactose rat brains. FGF-2/GSK-3 signaling pathway might be involved in the effects of Puerarin on hippocampal neurogenesis and tau hyperphosphorylation. Our finding provides primary in vivo evidence that Puerarin can attenuate AD-like enhanced hippocampal neurogenesis and tau hyperphosphorylation. Our finding also suggests Puerarin can be served as a treatment for age-related neurodegenerative disorders, such as AD.
authors.affiliation: Department of Anatomy and Histology, College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, People's Republic of China.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Hong
authors.affiliation: Department of Anatomy and Histology, College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Anatomy and Histology, College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, People's Republic of China.
authors.forename: Ni-Na
authors.initials: NN
authors.lastname: Yin
authors.affiliation: Department of Anatomy and Histology, College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, People's Republic of China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Han
authors.affiliation: Central Laboratory of College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yuan
authors.affiliation: Department of Anatomy and Histology, College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, People's Republic of China.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Duan
authors.affiliation: Department of Acupuncture and Moxibustion, College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Shen
authors.affiliation: Department of Anatomy and Histology, College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, People's Republic of China.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Zhang
authors.affiliation: Department of Anatomy and Histology, College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, People's Republic of China.
authors.forename: Ze-Bin
authors.initials: ZB
authors.lastname: Chen
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D005690:Galactose / Q000633:toxicity*; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D055495:Neurogenesis / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010766:Phosphorylation / Q000187:drug effects; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects; D065852:Spatial Memory / Q000187:drug effects / Q000502:physiology; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D007529:Isoflavones; C489131:Mapt protein, rat; D018696:Neuroprotective Agents; D016875:tau Proteins; D016222:Fibroblast Growth Factor 2; D038362:Glycogen Synthase Kinase 3; D005690:Galactose; C033607:puerarin
keywords: Alzheimer’s disease; Puerarin; glycogen synthase kinase; hippocampus; neurogenesis; spatial memory; tau hyperphosphorylation