title: Primary Pulmonary Synovial Sarcoma Showing a Prolonged Survival with Multimodality Therapy.
abstract: A 54-year-old man was referred to our hospital due to a mass shadow noted on a chest X-ray. Thoracoscopic lobectomy yielded a diagnosis of primary pulmonary synovial sarcoma according to the histology and SYT-SSX1 gene analyses. Five months after the thoracic surgery, he developed brain metastasis; therefore, we performed resection of the brain metastatic focus followed by radiotherapy. As a local recurrence in the thoracic cavity concurrently emerged, systemic chemotherapy was also administered. These observations indicated that a multidisciplinary approach may be useful against primary pulmonary synovial sarcoma, although there is presently no established therapeutic strategy due to its rarity and highly aggressive nature.
authors.affiliation: Department of Respiratory Medicine and Rheumatology, The University of Tokushima Graduate School, Institute of Health Biosciences, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Ogino
authors.forename: Masaki
authors.initials: M
authors.lastname: Hanibuchi
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takizawa
authors.forename: Shoji
authors.initials: S
authors.lastname: Sakiyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sumitomo
authors.forename: Seiji
authors.initials: S
authors.lastname: Iwamoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ikushima
authors.forename: Kohei
authors.initials: K
authors.lastname: Nakajima
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagahiro
authors.forename: Taito
authors.initials: T
authors.lastname: Yamago
authors.forename: Yuko
authors.initials: Y
authors.lastname: Toyoda
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Bando
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nishioka
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics / Q000556:secondary* / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods*; D004273:DNA, Neoplasm; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D013584:Sarcoma, Synovial / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D019616:Thoracic Surgical Procedures / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D004273:DNA, Neoplasm; D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein