title: The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders.
abstract: Phenolic compounds constitute a group of secondary metabolites which have important functions in plants. Besides the beneficial effects on the plant host, phenolic metabolites (polyphenols) exhibit a series of biological properties that influence the human in a health-promoting manner. Evidence suggests that people can benefit from plant phenolics obtained either by the diet or through skin application, because they can alleviate symptoms and inhibit the development of various skin disorders. Due to their natural origin and low toxicity, phenolic compounds are a promising tool in eliminating the causes and effects of skin aging, skin diseases, and skin damage, including wounds and burns. Polyphenols also act protectively and help prevent or attenuate the progression of certain skin disorders, both embarrassing minor problems (e.g., wrinkles, acne) or serious, potentially life-threatening diseases such as cancer. This paper reviews the latest reports on the potential therapy of skin disorders through treatment with phenolic compounds, considering mostly a single specific compound or a combination of compounds in a plant extract.
authors.affiliation: Faculty of Biotechnology, University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland. magdalena.dzialo@uwr.edu.pl.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Działo
authors.affiliation: Faculty of Biotechnology, University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland. juststw@o2.pl.
authors.forename: Justyna
authors.initials: J
authors.lastname: Mierziak
authors.affiliation: Faculty of Biotechnology, University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland. urszula.korzun@uwr.edu.pl.
authors.forename: Urszula
authors.initials: U
authors.lastname: Korzun
authors.affiliation: Faculty of Biotechnology, University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland. marta.preisner@gmail.com.
authors.forename: Marta
authors.initials: M
authors.lastname: Preisner
authors.affiliation: Faculty of Biotechnology, University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland. szopa@ibmb.uni.wroc.pl.|Department of Genetics, Plant Breeding and Seed Production, Faculty of Life Sciences and Technology, Wroclaw University of Environmental and Plant Sciences, Plac Grunwaldzki 24A, 53-363 Wroclaw, Poland. szopa@ibmb.uni.wroc.pl.
authors.forename: Jan
authors.initials: J
authors.lastname: Szopa
authors.affiliation: Faculty of Biotechnology, University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland. anna.kulma@uwr.edu.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Kulma
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002056:Burns / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D016922:Cellular Senescence / Q000187:drug effects; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010636:Phenols; D010936:Plant Extracts
keywords: anti-aging properties; anti-carcinogenic; anti-inflammatory; antimicrobial; antioxidant; phenolic compounds; skin diseases; wound healing