title: The First Report of a Pregnancy in a Patient with Purine Nucleoside Phosphorylase Deficiency.
abstract: BACKGROUND
  The cause of primary immunodeficiency has expanded to nearly 200 distinct disorders. An improved understanding of these disorders has resulted in decreased morbidity and mortality with reciprocal improved life expectancy. Obstetricians should have knowledge of primary immunodeficiency, as more women with these disorders will reach reproductive age.
  
  
  METHODS
  21-year-old G1P0 with purine nucleoside phosphorylase (PNP) deficiency delivered a viable infant vaginally at 37 weeks. Although the patient's diagnosis and pregnancy placed her at increased risk for infection, she remained asymptomatic and infection-free throughout pregnancy.
  
  
  CONCLUSIONS
  The management of pregnancy complicated by PNP deficiency requires strict immune surveillance and regimented immunoglobulin replacement.
authors.affiliation: a Indiana University School of Medicine , Indianapolis , Indiana , USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Martin
authors.affiliation: a Indiana University School of Medicine , Indianapolis , Indiana , USA.
authors.forename: Richa
authors.initials: R
authors.lastname: Sharma
authors.affiliation: a Indiana University School of Medicine , Indianapolis , Indiana , USA.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Nelson
authors.affiliation: a Indiana University School of Medicine , Indianapolis , Indiana , USA.
authors.forename: Frank
authors.initials: F
authors.lastname: Schubert
authors.affiliation: a Indiana University School of Medicine , Indianapolis , Indiana , USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Weida
mesh_terms: D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D018566:Pregnancy, High-Risk; D000081207:Primary Immunodeficiency Diseases; D011683:Purine-Nucleoside Phosphorylase / Q000172:deficiency*; D011686:Purine-Pyrimidine Metabolism, Inborn Errors; D055815:Young Adult
chemical_list: D011683:Purine-Nucleoside Phosphorylase
keywords: pregnancy; primary immunodeficiency; purine nucleoside phosphorylase deficiency