title: Solution Behavior of Amphiphilic Glycodendrimers with a Rod-Like Core.
abstract: Glycodendrimers based on aromatic cores have an amphiphilic character and have been reported to generate supramolecuar assemblies in water. A new group of glycodendrimers with an aromatic rod-like core were recently described as potent antagonists of DC-SIGN-mediated viral infections. A full characterization of the aggregation properties of these materials is presented here. The results show that these compounds exist mostly as monomers in water solution, in dynamic equilibrium with small aggregates (dimers or trimers). Larger aggregates observed by dynamic light scattering and transmission Electron Microscopy for some of the dendrimers are found to be portions of materials not fully solubilized and can be removed either by optimizing the dissolution protocol or by centrifugation of the samples.
authors.affiliation: Università degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, 20133, Milano, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Ordanini
authors.affiliation: Università degli Studi di Milano, Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Via Fratelli Cervi 93, 20090, Segrate, Milan, Italy.
authors.forename: Giuliano
authors.initials: G
authors.lastname: Zanchetta
authors.affiliation: Université Grenoble Alpes, IBS, F-38044, Grenoble, France.|CNRS, IBS, F-38044, Grenoble, France.|CEA, IBS, F-38044, Grenoble, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Porkolab
authors.affiliation: Université Grenoble Alpes, IBS, F-38044, Grenoble, France.|CNRS, IBS, F-38044, Grenoble, France.|CEA, IBS, F-38044, Grenoble, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Ebel
authors.affiliation: Université Grenoble Alpes, IBS, F-38044, Grenoble, France.|CNRS, IBS, F-38044, Grenoble, France.|CEA, IBS, F-38044, Grenoble, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Fieschi
authors.affiliation: Università degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, 20133, Milano, Italy.
authors.forename: Ileana
authors.initials: I
authors.lastname: Guzzetti
authors.affiliation: Università degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, 20133, Milano, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Potenza
authors.affiliation: Università degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, 20133, Milano, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Palmioli
authors.affiliation: University of Ljubljana, Faculty of Chemistry and Chemical Technology, Večna pot 113, 1000, Ljubljana, Slovenia.
authors.forename: Črtomir
authors.initials: Č
authors.lastname: Podlipnik
authors.affiliation: Università degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, 20133, Milano, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Meroni
authors.affiliation: Università degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, 20133, Milano, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Bernardi
mesh_terms: D015815:Cell Adhesion Molecules / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*; D037181:Lectins, C-Type / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D011956:Receptors, Cell Surface / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D050091:Dendrimers; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D012996:Solutions; D014867:Water; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
keywords: DC-SIGN; HIV; glycodendrimers; glycomimetics; morphological characterization