title: Transdiagnostic Treatment of Co-occurrence of Anxiety and Depressive Disorders based on Repetitive Negative Thinking: A Case Series.
abstract: OBJECTIVE
  The transdiagnostic cognitive behavioral treatments for treating the coexistence of anxiety and mood disorders received useful empirical supports in the recent years. However, these treatments still have moderate efficacy. Following the improvements and developments in transdiagnostic protocols and considering the importance of repetitive negative thinking as a core transdiagnostic factor in emotional disorders, this study examined a new form of transdiagnostic treatment based on Repetitive Negative Thinking (TTRNT) of co-occurrence of anxiety and depressive disorders.
  
  
  METHODS
  Treatment efficacy was assessed using single case series with multiple baselines. Three patients meeting the criteria for co-occurrence of anxiety and depressive disorders were selected using the Anxiety Disorders Interview Schedule for DSM-IV. The patients were treated individually for 12 weekly sessions. Participants completed the standardized outcome measures during the baseline, treatment and one-month follow-up.
  
  
  RESULTS
  At post-treatment, all participants showed significant clinical changes on a range of standardized outcome measures, and these gains were largely maintained through the one-month follow-up both in the principle and co-principal diagnosis.
  
  
  CONCLUSIONS
  Although the results of this preliminary investigation indicated that TTRNT could be a time effective and efficient treatment for individuals with co-occurrence of anxiety and depressive disorders, further controlled clinical trials are necessary to examine this new treatment approach.
authors.affiliation: Kharazmi University, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Akbari
authors.affiliation: Shahed University, Tehran, Iran.
authors.forename: Rasool
authors.initials: R
authors.lastname: Roshan
authors.affiliation: Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Shabani
authors.affiliation: Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Ladan
authors.initials: L
authors.lastname: Fata
authors.affiliation: Shahed University, Tehran, Iran.
authors.forename: Mohamad Reza
authors.initials: MR
authors.lastname: Shairi
authors.affiliation: Shahed University, Tehran, Iran.
authors.forename: Firouzeh
authors.initials: F
authors.lastname: Zarghami
keywords: Anxiety; Depression.; Repetitive Negative Thinking; Transdiagnostic Treatment