title: Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-1 signaling pathway.
abstract: Paeoniflorin (PF), one of the major active ingredients of Chinese peony, was reported to possess anti-tumor effect. However, the role of PF in breast cancer remains to be clarified. Therefore, in this context, the present study investigated the effects of PF on breast cancer cell proliferation and invasion, as well as the underlying mechanism. Our results found that PF suppressed the proliferation and invasion of breast cancer cells. We further demonstrated that PF down-regulated the expression of Notch-1; in addition, overexpression of Notch-1 reversed PF-inhibited proliferation and invasion, and knockdown of Notch-1 enhanced PF-inhibited proliferation and invasion in breast cancer cells. In conclusion, the present study suggests that PF inhibits proliferation and invasion of breast cancer cells through suppressing Notch-1 signaling pathway. Therefore, PF may represent a chemopreventive and/or therapeutic agent in the prevention of breast cancer.
authors.affiliation: Department of Breast Surgery, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Infection, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Endocrine Surgery, People's Hospital of Liaoning Province, Shenyang 110016, China.
authors.forename: Jianchun
authors.initials: J
authors.lastname: Cui
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, 999077, Hong Kong, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Xiao
authors.affiliation: Department of Breast Surgery, Liaoning Cancer Hospital & Institute, Shenyang 110042, China. Electronic address: jiang_daqing@126.com.
authors.forename: Daqing
authors.initials: D
authors.lastname: Jiang
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D055785:Gene Knockdown Techniques; D005960:Glucosides / Q000494:pharmacology*; D006801:Humans; D039821:Monoterpenes / Q000494:pharmacology*; D009361:Neoplasm Invasiveness; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*; D006027:Glycosides
chemical_list: D005960:Glucosides; D039821:Monoterpenes; D051880:Receptors, Notch; C015423:peoniflorin; D006027:Glycosides
keywords: Breast cancer; Invasion; Notch-1; Paeoniflorin; Proliferation