title: Surface Molecularly Imprinted Polymer of Chitosan Grafted Poly(methyl methacrylate) for 5-Fluorouracil and Controlled Release.
abstract: The molecular surface imprinted graft copolymer of chitosan with methyl methacrylate (MIP-CS-g-PMMA) were prepared by free radical polymerization with 5-fluorouracil (5-FU) as the template molecule using initiator of ammonium persulfate as adsorption system. MIPs were characterized by FTIR, X-ray diffraction, thermo-gravimetric analysis, (1)H NMR and SEM. The mechanism of graft copolymerization and factors affected graft reaction were studied in details, and the optimum reaction conditions (to the highest %G and %E as the standard) were obtained at [MMA] 1.2 mol/L, [Chitosan] 16.67 mol/L, [initiator] 0.0062 mol/L, temperature 60 °C and reaction time 7 h. MIPs exhibited high recognition selectivity and excellent combining affinity to template molecular. The in vitro release of the 5-FU was highly pH-dependent and time delayed. The release behavior showed that the drugs did not release in simulated gastric fluid (pH = 1.0), and the drug release was small in the simulated small intestinal fluid (pH = 6.8), and drug abrupt release will be produced in the simulated colon fluid (pH = 7.4), indicating excellent colon-specific drug delivery behavior.
authors.affiliation: College of Chemical Engineering, Hebei Normal University of Science and Technology, Qinhuangdao 066600, China.
authors.forename: Xue-Fang
authors.initials: XF
authors.lastname: Zheng
authors.affiliation: College of Chemical Engineering, Hebei Normal University of Science and Technology, Qinhuangdao 066600, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Lian
authors.affiliation: School of Chemistry and Chemical Engineering of Guangxi University, Nanning, 530004, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: College of Life Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066600, China.
authors.forename: Xiuping
authors.initials: X
authors.lastname: Wang
mesh_terms: D000327:Adsorption; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005472:Fluorouracil / Q000008:administration & dosage*; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D054802:Molecular Imprinting / Q000379:methods; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D019904:Polymethyl Methacrylate; D048271:Chitosan; D005472:Fluorouracil