title: A Mn(II) complex of boradiazaindacene (BODIPY) loaded graphene oxide as both LED light and H2O2 enhanced anticancer agent.
abstract: Cancer cells are more susceptible to H2O2 induced cell death than normal cells. H2O2-activatable and O2-evolving nanoparticles could be used as photodynamic therapy agents in hypoxic environments. In this report, a photo-active Mn(II) complex of boradiazaindacene derivatives (Mn1) was used as a dioxygen generator under irradiation with LED light in water. Moreover, the in vitro biological evaluation for Mn1 and its loaded graphene oxide (herein called Mn1@GO) on HepG-2 cells in normal and hypoxic conditions has been performed. In particular, Mn1@GO can react with H2O2 resulting active anticancer species, which show high inhibition on both HepG-2 cells and CoCl2-treated HepG-2 cells (hypoxic cancer cells). The mechanism of LED light enhanced anticancer activity for Mn1@GO on HepG-2 cells was discussed. Our results show that Mn(II) complexes of boradiazaindacene (BODIPY) derivatives loaded GO can be both LED light and H2O2-activated anticancer agents in hypoxic environments.
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Xu
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Shao
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China; School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China. Electronic address: chenqy@ujs.edu.cn.
authors.forename: Qiu-Yun
authors.initials: QY
authors.lastname: Chen
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
authors.forename: Cheng-Hao
authors.initials: CH
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
authors.forename: Meng-Yun
authors.initials: MY
authors.lastname: Kong
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Fang
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Ji
authors.affiliation: School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China.
authors.forename: Daniel
authors.initials: D
authors.lastname: Boison
authors.affiliation: School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.affiliation: School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.affiliation: College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Chang-Jian
authors.initials: CJ
authors.lastname: Feng
mesh_terms: D000970:Antineoplastic Agents; D001896:Boron Compounds / Q000737:chemistry / Q000494:pharmacology; D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008027:Light
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000970:Antineoplastic Agents; D001896:Boron Compounds; D003035:Cobalt; D006108:Graphite; D006861:Hydrogen Peroxide; C018021:cobaltous chloride
keywords: Cancer; Graphene; H(2)O(2)-activatable; Manganese; Photodynamic