title: Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer.
abstract: Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally, CRISPR/Cas9-mediated knockout of CDH1 in bladder cancer cells enhanced cell migration.
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Hikmat A
authors.initials: HA
authors.lastname: Al-Ahmadie
authors.affiliation: Weill Cornell Medical College, Cornell University, New York, New York, USA.|Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Gopa
authors.identifier: http://orcid.org/0000-0002-5093-6099
authors.initials: G
authors.lastname: Iyer
authors.affiliation: Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Byron H
authors.initials: BH
authors.lastname: Lee
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Sasinya N
authors.initials: SN
authors.lastname: Scott
authors.affiliation: Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan, USA.
authors.forename: Rohit
authors.initials: R
authors.lastname: Mehra
authors.affiliation: Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Aditya
authors.initials: A
authors.lastname: Bagrodia
authors.affiliation: Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Emmet J
authors.initials: EJ
authors.lastname: Jordan
authors.affiliation: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Sizhi Paul
authors.initials: SP
authors.lastname: Gao
authors.affiliation: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.|Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York, USA.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ramirez
authors.affiliation: Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Eugene K
authors.identifier: http://orcid.org/0000-0002-8807-2353
authors.initials: EK
authors.lastname: Cha
authors.affiliation: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Neil B
authors.initials: NB
authors.lastname: Desai
authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Emily C
authors.initials: EC
authors.lastname: Zabor
authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Irina
authors.initials: I
authors.lastname: Ostrovnaya
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Gopalan
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Ying-Bei
authors.initials: YB
authors.lastname: Chen
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Samson W
authors.initials: SW
authors.lastname: Fine
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Satish K
authors.initials: SK
authors.lastname: Tickoo
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Anupama
authors.initials: A
authors.lastname: Gandhi
authors.affiliation: Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Hreiki
authors.affiliation: Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Agnès
authors.initials: A
authors.lastname: Viale
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.|Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Arcila
authors.affiliation: Weill Cornell Medical College, Cornell University, New York, New York, USA.|Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Guido
authors.initials: G
authors.lastname: Dalbagni
authors.affiliation: Weill Cornell Medical College, Cornell University, New York, New York, USA.|Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Rosenberg
authors.affiliation: Weill Cornell Medical College, Cornell University, New York, New York, USA.|Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Bernard H
authors.initials: BH
authors.lastname: Bochner
authors.affiliation: Weill Cornell Medical College, Cornell University, New York, New York, USA.|Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Dean F
authors.initials: DF
authors.lastname: Bajorin
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.|Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Berger
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.|Weill Cornell Medical College, Cornell University, New York, New York, USA.
authors.forename: Victor E
authors.initials: VE
authors.lastname: Reuter
authors.affiliation: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.|Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.|Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Barry S
authors.initials: BS
authors.lastname: Taylor
authors.affiliation: Weill Cornell Medical College, Cornell University, New York, New York, USA.|Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.|Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.|Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: David B
authors.initials: DB
authors.lastname: Solit
mesh_terms: D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics*; D045744:Cell Line, Tumor; D004252:DNA Mutational Analysis; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015999:Multivariate Analysis; D009154:Mutation; D010954:Plasmacytoma / Q000235:genetics*; D016016:Proportional Hazards Models; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000401:mortality
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins