title: Effects of cisplatin chemotherapy on the osseointegration of titanium implants.
abstract: OBJECTIVE
  The effect of chemotherapy on the osseointegration of dental implants has received less interest compared with radiotherapy. Thus, the aim of the current study was to investigate the effect of cisplatin chemotherapy on the osseointegration of dental implants in a rabbit model.
  
  
  METHODS
  Sixteen New Zealand White rabbits were randomly assigned to two groups of treatment of either cisplatin at 2.5 mg/kg/week for 4 weeks (n = 8) or placebo (n = 8), in which the first dose was administered 2 days prior to the surgical procedure. Each rabbit received one titanium dental implant inserted in the right distal femoral condyle. Four rabbits from each group were sacrificed 4 and 8 weeks after implant insertion. Osseointegration of the dental implants was analysed using micro-computed tomography and histomorphometric evaluation.
  
  
  RESULTS
  Analysis of micro-computed tomography data and histomorphometric data showed that the osseointegration parameters, including the ratio of bone volume to total volume (BV/TV) and bone-implant contact (BIC%) for the cisplatin group, were significantly lower compared to the control group at 4 and 8 weeks. (P ≤ 0.05).
  
  
  CONCLUSIONS
  Cisplatin chemotherapy had a negative effect on the osseointegration of dental implants when inserted throughout the chemotherapeutic regimens in a rabbit model.
authors.affiliation: Biomedical Dental Sciences Department, College of Dentistry, University of Dammam, P.O. Box 1982, Dammam, 31441, Saudi Arabia. Electronic address: haelmahalawy@uod.edu.sa.
authors.forename: Haytham
authors.initials: H
authors.lastname: Al-Mahalawy
authors.affiliation: Biomedical Dental Sciences Department, College of Dentistry, University of Dammam, P.O. Box 1982, Dammam, 31441, Saudi Arabia. Electronic address: hmarei@uod.edu.sa.
authors.forename: Hesham F
authors.initials: HF
authors.lastname: Marei
authors.affiliation: Biomedical Dental Sciences Department, College of Dentistry, University of Dammam, P.O. Box 1982, Dammam, 31441, Saudi Arabia. Electronic address: habuohashish@uod.edu.sa.
authors.forename: Hatem
authors.initials: H
authors.lastname: Abuohashish
authors.affiliation: Center of Research and Medical Consultation, University of Dammam, Dammam, 31441, Saudi Arabia. Electronic address: Haalhawaj@uod.edu.sa.
authors.forename: Hussain
authors.initials: H
authors.lastname: Alhawaj
authors.affiliation: Department of Internal Medicine, Oncology & Hematology, College of Medicine, University of Dammam, Dammam, Saudi Arabia. Electronic address: mrefaee@uod.edu.sa.
authors.forename: Munir
authors.initials: M
authors.lastname: Alrefaee
authors.affiliation: Biomedical Dental Sciences Department, College of Dentistry, University of Dammam, P.O. Box 1982, Dammam, 31441, Saudi Arabia. Electronic address: baljandan@uod.edu.sa.
authors.forename: Badr
authors.initials: B
authors.lastname: Al-Jandan
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous; D016348:Osseointegration / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D013499:Surface Properties; D014025:Titanium; D055114:X-Ray Microtomography
chemical_list: D014025:Titanium; D002945:Cisplatin
keywords: Chemotherapy; Cisplatin; Dental implants; Histomorphometry; Micro-computed tomography; Osseointegration