title: RhesusBase PopGateway: Genome-Wide Population Genetics Atlas in Rhesus Macaque.
abstract: Although population genetics studies have significantly accelerated the evolutionary and functional interrogations of genes and regulations, limited polymorphism data are available for rhesus macaque, the model animal closely related to human. Here, we report the first genome-wide effort to identify and visualize the population genetics profile in rhesus macaque. On the basis of the whole-genome sequencing of 31 independent macaque animals, we profiled a comprehensive polymorphism map with 46,146,548 sites. The allele frequency for each polymorphism site, the haplotype structure, as well as multiple population genetics parameters were then calculated on a genome-wide scale. We further developed a specific interface, the RhesusBase PopGateway, to facilitate the visualization of these annotations, and highlighted the applications of this highly integrative platform in clarifying the selection signatures of genes and regulations in the context of the primate evolution. Overall, the updated RhesusBase provides a comprehensive monkey population genetics framework for in-depth evolutionary studies of human biology.
authors.affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zhong
authors.affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Jiguang
authors.initials: J
authors.lastname: Peng
authors.affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Qing Sunny
authors.initials: QS
authors.lastname: Shen
authors.affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Jia-Yu
authors.initials: JY
authors.lastname: Chen
authors.affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Han
authors.initials: H
authors.lastname: Gao
authors.affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China Peking-Tsinghua Center for Life Sciences, Beijing, China Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
authors.forename: Xuke
authors.initials: X
authors.lastname: Luan
authors.affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Shouyu
authors.initials: S
authors.lastname: Yan
authors.affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Shi-Jian
authors.initials: SJ
authors.lastname: Zhang
authors.affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Luying
authors.initials: L
authors.lastname: Xu
authors.affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Xiuqin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Biomedical Sciences and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan Molecular Medicine Research Center, Chang Gung University, Tao-Yuan, Taiwan.
authors.forename: Bertrand Chin-Ming
authors.initials: BC
authors.lastname: Tan
authors.affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China chuanyunli@pku.edu.cn.
authors.forename: Chuan-Yun
authors.initials: CY
authors.lastname: Li
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002681:China; D030561:Databases, Nucleic Acid; D005828:Genetics, Population / Q000379:methods; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008253:Macaca mulatta / Q000235:genetics*; D056186:Metagenomics / Q000379:methods / Q000592:standards; D017422:Sequence Analysis, DNA / Q000379:methods
keywords: RhesusBase.; population genetics; primate evolution; rhesus macaque; whole-genome sequencing