title: Nanoparticles of gadolinium-incorporated Prussian blue with PEG coating as an effective oral MRI contrast agent for gastrointestinal tract imaging.
abstract: Biocompatible nanoparticles of gadolinium-incorporated Prussian blue with the empirical formula K(0.94)Gd(0.02)Fe[Fe(CN)6] exhibit extremely high stability against the release of Gd(3+) and CN(-) ions under the acidic conditions similar to stomach juice. The high r1 relaxivity, low cytotoxicity and the ability of such nanoparticles to penetrate the cell membrane suggest that this coordination-polymer structural platform offers a unique opportunity for developing the next generation of T1-weighted oral cellular MRI probes for the early detection of tumors in the gastrointestinal tract.
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.
authors.forename: Vindya S
authors.initials: VS
authors.lastname: Perera
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.
authors.forename: Guojun
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Radiology, Suzhou University-Affiliated Hospital, Nanjing Medical University, Suzhou, 215123, Jiangsu Province, China. caiq1202@163.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Cai
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.
authors.forename: Songping D
authors.initials: SD
authors.lastname: Huang
mesh_terms: D000818:Animals; D001692:Biological Transport; D003287:Contrast Media / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D004355:Drug Stability; D005295:Ferrocyanides / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging*; D019073:HT29 Cells; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011817:Rabbits
chemical_list: D003287:Contrast Media; D005295:Ferrocyanides; D011092:Polyethylene Glycols; D005682:Gadolinium; C000170:ferric ferrocyanide