title: Carbapenem- and Colistin-Resistant Enterobacter cloacae from Delta, Colorado, in 2015.
abstract: Resistance to carbapenems in Enterobacteriaceae is a clinical problem of growing significance. Difficulty in treating multidrug-resistant Gram-negative organisms with conventional antibiotics has led to a renewed and increasing use of polymyxin compounds, such as colistin. Here, we report the isolation of carbapenem- and colistin-resistant Enterobacter cloacae from a polymicrobial lower extremity wound in an ambulatory patient. Whole-genome sequencing demonstrated the presence of chromosomal blaIMI-1 and blaAmpC, as well as numerous efflux pump genes.
authors.affiliation: Department of Laboratory Medicine and Pathology, Rochester, Minnesota, USA.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Norgan
authors.affiliation: Delta County Memorial Hospital, Delta, Colorado, USA.
authors.forename: Jarred M
authors.initials: JM
authors.lastname: Freese
authors.affiliation: Delta County Memorial Hospital, Delta, Colorado, USA.
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Tuin
authors.affiliation: Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Cunningham
authors.affiliation: Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Patricio R
authors.identifier: 0000-0003-0282-4217
authors.initials: PR
authors.lastname: Jeraldo
authors.affiliation: Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA patel.robin@mayo.edu.
authors.forename: Robin
authors.identifier: 0000-0001-6344-4141
authors.initials: R
authors.lastname: Patel
mesh_terms: D015780:Carbapenems / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D003120:Colorado; D018432:Drug Resistance, Multiple; D016972:Enterobacter cloacae / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
chemical_list: D015780:Carbapenems; D003091:Colistin