title: Effects of an acute bout of moderate-intensity exercise on postprandial lipemia and airway inflammation.
abstract: A high-fat meal (HFM) induces an increase in blood lipids (postprandial lipemia; PPL), systemic inflammation, and acute airway inflammation. While acute exercise has been shown to have anti-inflammatory and lipid-lowering effects, it is unknown whether exercise prior to an HFM will translate to reduced airway inflammation post-HFM. Our purpose was to determine the effects of an acute bout of exercise on airway inflammation post-HFM and to identify whether any protective effect of exercise on airway inflammation was associated with a reduction in PPL or systemic inflammation. In a randomized cross-over study, 12 healthy, 18- to 29-year-old men (age, 23.0 ± 3.2 years; height, 178.9 ± 5.5 cm; weight, 78.5 ± 11.7 kg) consumed an HFM (1 g fat/1 kg body weight) 12 h following exercise (EX; 60 min at 60% maximal oxygen uptake) or without exercise (CON). Fractional exhaled nitric oxide (FENO; measure of airway inflammation), triglycerides (TG), and inflammatory markers (high-sensitivity C-reactive protein, tumor-necrosis factor-alpha, and interleukin-6) were measured while fasted at 2 h and 4 h post-HFM. FENO increased over time (2 h: CON, p = 0.001; EX, p = 0.002, but not by condition (p = 0.991). TG significantly increased 2 and 4 h post-HFM (p < 0.001), but was not significant between conditions (p = 0.256). Inflammatory markers did not significantly increase by time or condition (p > 0.05). There were no relationships between FENO and TG or systemic inflammatory markers for any time point or condition (p > 0.05). In summary, an acute bout of moderate-intensity exercise performed 12 h prior to an HFM did not change postprandial airway inflammation or lipemia in healthy, 18- to 29-year-old men.
authors.affiliation: a Department of Kinesiology, Kansas State University, 1A Natatorium, Manhattan, KS 66506, USA.
authors.forename: Ariel M
authors.initials: AM
authors.lastname: Johnson
authors.affiliation: a Department of Kinesiology, Kansas State University, 1A Natatorium, Manhattan, KS 66506, USA.
authors.forename: Stephanie P
authors.initials: SP
authors.lastname: Kurti
authors.affiliation: a Department of Kinesiology, Kansas State University, 1A Natatorium, Manhattan, KS 66506, USA.
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Smith
authors.affiliation: b Department of Food, Nutrition, Dietetics, and Health, Kansas State University, Manhattan, KS 66506, USA.
authors.forename: Sara K
authors.initials: SK
authors.lastname: Rosenkranz
authors.affiliation: a Department of Kinesiology, Kansas State University, 1A Natatorium, Manhattan, KS 66506, USA.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Harms
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001944:Breath Tests; D018592:Cross-Over Studies; D059305:Diet, High-Fat; D015444:Exercise; D005080:Exercise Test; D005541:Forced Expiratory Volume; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000175:diagnosis; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000097:blood; D008055:Lipids / Q000097:blood*; D008168:Lung / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D019518:Postprandial Period; D013997:Time Factors; D014797:Vital Capacity; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D008055:Lipids; D009569:Nitric Oxide
keywords: dyslipidemia; dyslipémie; exercice physique; exercise; exercise metabolism; inflammation; métabolisme à l’effort; physiologie pulmonaire; pulmonary physiology