title: Combined effect of individual and neighborhood socioeconomic status on mortality in patients with newly diagnosed dyslipidemia: A nationwide Korean cohort study from 2002 to 2013.
abstract: OBJECTIVE
  The study aims to determine whether dyslipidemia patients living in less affluent neighborhood are at a higher risk of mortality compared to those living in more affluent neighborhoods.
  
  
  RESULTS
  A population-based cohort study was conducted using a stratified representative sampling from the National Health Insurance claim data from 2002 to 2013. The target subjects comprise patients newly diagnosed with dyslipidemia receiving medication. We performed a survival analysis using the Cox proportional hazard model. Of 11,946 patients with dyslipidemia, 1053 (8.8%) subjects died during the follow-up period. Of the dyslipidemia patients earning a middle-class income, the adjusted HR in less affluent neighborhoods was higher than that in the more affluent neighborhoods compared to the reference category of high individual SES in more affluent neighborhoods (less affluent; hazard ratio (HR) = 1.64, 95% confidence interval (CI): 1.35-1.99 vs. more affluent; HR = 1.48, 95% CI: 1.20-1.81, respectively). We obtained consistent results in patients with lower income, wherein the adjusted HR in less affluent neighborhoods was higher than that in more affluent neighborhoods (less affluent; HR = 1.52, 95% CI: 1.16-1.97 vs. more affluent; HR = 1.41, 95% CI: 1.04-1.92, respectively).
  
  
  CONCLUSIONS
  Living in a less affluent neighborhood contributes to higher mortality among dyslipidemia patients. The individual- and neighborhood-level variables cumulatively affect individuals such that the most at-risk individuals include those having both individual- and neighborhood-level risk factors. These findings raise important clinical and public health concerns and indicate that neighborhood SES approaches should be essentially considered in health-care policies similar to individual SES.
authors.affiliation: Institute of Health Services Research, College of Medicine, Yonsei University, South Korea; Department of Preventive Medicine, College of Medicine, Yonsei University, South Korea.
authors.forename: J
authors.initials: J
authors.lastname: Shin
authors.affiliation: Department of Public Health, Graduate School, Yonsei University, South Korea; Institute of Health Services Research, College of Medicine, Yonsei University, South Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Cho
authors.affiliation: Department of Public Health, Graduate School, Yonsei University, South Korea; Institute of Health Services Research, College of Medicine, Yonsei University, South Korea.
authors.forename: Y
authors.initials: Y
authors.lastname: Choi
authors.affiliation: Institute of Health Services Research, College of Medicine, Yonsei University, South Korea; Department of Hospital Management, Graduate School of Public Health, Yonsei University, South Korea.
authors.forename: S G
authors.initials: SG
authors.lastname: Lee
authors.affiliation: Institute of Health Services Research, College of Medicine, Yonsei University, South Korea; Department of Preventive Medicine, College of Medicine, Yonsei University, South Korea.
authors.forename: E-C
authors.initials: EC
authors.lastname: Park
authors.affiliation: Institute of Health Services Research, College of Medicine, Yonsei University, South Korea; Department of Preventive Medicine, College of Medicine, Yonsei University, South Korea. Electronic address: jangsi@yuhs.ac.
authors.forename: S-I
authors.initials: SI
authors.lastname: Jang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D050171:Dyslipidemias / Q000175:diagnosis* / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009313:National Health Programs; D016016:Proportional Hazards Models; D056910:Republic of Korea / Q000453:epidemiology; D012111:Residence Characteristics; D012307:Risk Factors; D012959:Socioeconomic Factors; D016019:Survival Analysis; D055815:Young Adult
keywords: Dyslipidemia; Hypercholesterolemia; Hypertriglyceridemia; Mortality; Neighborhood; Socioeconomic status