title: Changes in extra-striatal functional connectivity in patients with schizophrenia in a psychotic episode.
abstract: In patients with schizophrenia in a psychotic episode, intra-striatal intrinsic connectivity is increased in the putamen but not ventral striatum. Furthermore, multimodal changes have been observed in the anterior insula that interact extensively with the putamen.
  
  
  
  We hypothesised that during psychosis, putamen extra-striatal functional connectivity is altered with both the anterior insula and areas normally connected with the ventral striatum (i.e. altered functional connectivity distinctiveness of putamen and ventral striatum).
  
  
  
  We acquired resting-state functional magnetic resonance images from 21 patients with schizophrenia in a psychotic episode and 42 controls.
  
  
  
  Patients had decreased functional connectivity: the putamen with right anterior insula and dorsal prefrontal cortex, the ventral striatum with left anterior insula. Decreased functional connectivity between putamen and right anterior insula was specifically associated with patients' hallucinations. Functional connectivity distinctiveness was impaired only for the putamen.
  
  
  
  Results indicate aberrant extra-striatal connectivity during psychosis and a relationship between reduced putamen-right anterior insula connectivity and hallucinations. Data suggest that altered intrinsic connectivity links striatal and insular pathophysiology in psychosis.
authors.affiliation: Henning Peters, MD, PhD, Department of Psychiatry and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Valentin Riedl, MD, PhD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Andrei Manoliu, MD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany and Department of Radiology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland; Martin Scherr, MD, Dirk Schwerthöffer, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Claus Zimmer, MD, Department of Neuroradiology, Technische Universität München, Munich, Germany; Hans Förstl, MD, Josef Baüml, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Christian Sorg, MD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Kathrin Koch, PhD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Henning
authors.initials: H
authors.lastname: Peters
authors.affiliation: Henning Peters, MD, PhD, Department of Psychiatry and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Valentin Riedl, MD, PhD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Andrei Manoliu, MD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany and Department of Radiology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland; Martin Scherr, MD, Dirk Schwerthöffer, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Claus Zimmer, MD, Department of Neuroradiology, Technische Universität München, Munich, Germany; Hans Förstl, MD, Josef Baüml, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Christian Sorg, MD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Kathrin Koch, PhD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Valentin
authors.initials: V
authors.lastname: Riedl
authors.affiliation: Henning Peters, MD, PhD, Department of Psychiatry and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Valentin Riedl, MD, PhD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Andrei Manoliu, MD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany and Department of Radiology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland; Martin Scherr, MD, Dirk Schwerthöffer, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Claus Zimmer, MD, Department of Neuroradiology, Technische Universität München, Munich, Germany; Hans Förstl, MD, Josef Baüml, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Christian Sorg, MD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Kathrin Koch, PhD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Andrei
authors.initials: A
authors.lastname: Manoliu
authors.affiliation: Henning Peters, MD, PhD, Department of Psychiatry and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Valentin Riedl, MD, PhD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Andrei Manoliu, MD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany and Department of Radiology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland; Martin Scherr, MD, Dirk Schwerthöffer, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Claus Zimmer, MD, Department of Neuroradiology, Technische Universität München, Munich, Germany; Hans Förstl, MD, Josef Baüml, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Christian Sorg, MD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Kathrin Koch, PhD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Scherr
authors.affiliation: Henning Peters, MD, PhD, Department of Psychiatry and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Valentin Riedl, MD, PhD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Andrei Manoliu, MD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany and Department of Radiology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland; Martin Scherr, MD, Dirk Schwerthöffer, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Claus Zimmer, MD, Department of Neuroradiology, Technische Universität München, Munich, Germany; Hans Förstl, MD, Josef Baüml, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Christian Sorg, MD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Kathrin Koch, PhD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Schwerthöffer
authors.affiliation: Henning Peters, MD, PhD, Department of Psychiatry and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Valentin Riedl, MD, PhD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Andrei Manoliu, MD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany and Department of Radiology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland; Martin Scherr, MD, Dirk Schwerthöffer, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Claus Zimmer, MD, Department of Neuroradiology, Technische Universität München, Munich, Germany; Hans Förstl, MD, Josef Baüml, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Christian Sorg, MD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Kathrin Koch, PhD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Claus
authors.initials: C
authors.lastname: Zimmer
authors.affiliation: Henning Peters, MD, PhD, Department of Psychiatry and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Valentin Riedl, MD, PhD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Andrei Manoliu, MD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany and Department of Radiology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland; Martin Scherr, MD, Dirk Schwerthöffer, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Claus Zimmer, MD, Department of Neuroradiology, Technische Universität München, Munich, Germany; Hans Förstl, MD, Josef Baüml, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Christian Sorg, MD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Kathrin Koch, PhD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Hans
authors.initials: H
authors.lastname: Förstl
authors.affiliation: Henning Peters, MD, PhD, Department of Psychiatry and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Valentin Riedl, MD, PhD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Andrei Manoliu, MD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany and Department of Radiology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland; Martin Scherr, MD, Dirk Schwerthöffer, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Claus Zimmer, MD, Department of Neuroradiology, Technische Universität München, Munich, Germany; Hans Förstl, MD, Josef Baüml, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Christian Sorg, MD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Kathrin Koch, PhD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Josef
authors.initials: J
authors.lastname: Bäuml
authors.affiliation: Henning Peters, MD, PhD, Department of Psychiatry and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Valentin Riedl, MD, PhD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Andrei Manoliu, MD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany and Department of Radiology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland; Martin Scherr, MD, Dirk Schwerthöffer, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Claus Zimmer, MD, Department of Neuroradiology, Technische Universität München, Munich, Germany; Hans Förstl, MD, Josef Baüml, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Christian Sorg, MD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Kathrin Koch, PhD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Sorg
authors.affiliation: Henning Peters, MD, PhD, Department of Psychiatry and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Valentin Riedl, MD, PhD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Andrei Manoliu, MD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany and Department of Radiology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland; Martin Scherr, MD, Dirk Schwerthöffer, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Claus Zimmer, MD, Department of Neuroradiology, Technische Universität München, Munich, Germany; Hans Förstl, MD, Josef Baüml, MD, Department of Psychiatry, Technische Universität München, Munich, Germany; Christian Sorg, MD, Department of Psychiatry, Department of Neuroradiology, Department of Nuclear Medicine and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Kathrin Koch, PhD, Department of Neuroradiology and TUM-Neuroimaging Center Klinikum rechts der Isar, Technische Universität München, Munich, Germany kathrin.koch@tum.de.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Koch
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D063132:Connectome / Q000379:methods*; D005260:Female; D006212:Hallucinations / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000503:physiopathology*; D011699:Putamen / Q000503:physiopathology*; D012559:Schizophrenia / Q000503:physiopathology*; D066328:Ventral Striatum / Q000503:physiopathology*