title: Glaucocalyxin A inhibits the growth of liver cancer Focus and SMMC-7721 cells.
abstract: Liver cancer is one of the most common types of cancer, and hepatoma demonstrates a poor long-term prognosis. The present study reports that glaucocalyxin A (GLA), a natural product isolated fromRabdosia umbrosa, inhibits the growth of the liver cancer Focus and SMMC-7721 cell lines in a dose- and time-dependent manner. The present study revealed that GLA arrested the liver cancer cells at the G2/M stage of the cell cycle and led to decreased expression of caspase 3 and the cleavage of poly(adenosine diphosphate-ribose) polymerase. Overall, the present study demonstrated that GLA inhibits the growth of liver cancer cells by G2/M stage cell-cycle arrest and cell apoptosis.
authors.affiliation: School of Life Sciences, Fudan University, State Key Laboratory of Genetic Engineering, Shanghai 200433, P.R. China.
authors.forename: Lisha
authors.initials: L
authors.lastname: Tang
authors.affiliation: School of Life Sciences, Fudan University, State Key Laboratory of Genetic Engineering, Shanghai 200433, P.R. China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Jin
authors.affiliation: School of Life Sciences, Fudan University, State Key Laboratory of Genetic Engineering, Shanghai 200433, P.R. China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Hu
authors.affiliation: School of Life Sciences, Fudan University, State Key Laboratory of Genetic Engineering, Shanghai 200433, P.R. China.
authors.forename: Xiaoding
authors.initials: X
authors.lastname: Hu
authors.affiliation: School of Life Sciences, Fudan University, State Key Laboratory of Genetic Engineering, Shanghai 200433, P.R. China.
authors.forename: Zulong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Life Sciences, Fudan University, State Key Laboratory of Genetic Engineering, Shanghai 200433, P.R. China.
authors.forename: Long
authors.initials: L
authors.lastname: Yu
keywords: G2/M arrest; apoptosis; growth inhibition; liver cancer