title: The role of anti-myosin antibodies in perpetuating cardiac damage following myocardial infarction.
abstract: Recent improvements in the medical and surgical management of myocardial infarction mean that many patients are now surviving with greater impairment of cardiac function. Despite appropriate management, some of these patients subsequently develop pathological ventricular remodelling, which compounds their contractile dysfunction and can lead to congestive cardiac failure (CCF). The pathophysiological mechanism underpinning this process remains incompletely understood. One hypothesis suggests that a post-infarction autoimmune response, directed against constituents of cardiac myocytes, including cardiac myosin, may make an important contribution. Our review summarises the current literature related to the formation and clinical relevance of anti-myosin antibodies (AMAs) in patients with myocardial infarction. This discussion is supplemented with reference to a number of important animal studies, which provide evidence of the potential mechanisms underlying AMA formation and autoantibody mediated cardiac dysfunction.
authors.affiliation: Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland 4811, Australia; Department of Cardiology, The Townsville Hospital and Health Service, Townsville, Queensland 4811, Australia.
authors.forename: Tom J
authors.initials: TJ
authors.lastname: O'Donohoe
authors.affiliation: Department of Cardiology, The Townsville Hospital and Health Service, Townsville, Queensland 4811, Australia; College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia.
authors.forename: Ryan G
authors.initials: RG
authors.lastname: Schrale
authors.affiliation: Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland 4811, Australia; College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia; College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland 4811, Australia. Electronic address: n.ketheesan@jcu.edu.au.
authors.forename: Natkunam
authors.initials: N
authors.lastname: Ketheesan
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity / Q000502:physiology; D024722:Cardiac Myosins / Q000097:blood*; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis*; D009206:Myocardium / Q000473:pathology
chemical_list: D001323:Autoantibodies; D024722:Cardiac Myosins
keywords: Anti-myosin antibodies; Autoantibody; Autoimmunity; Ischaemic heart disease; Myocardial infarction