title: Protein regulator of cytokinesis 1 overexpression predicts biochemical recurrence in men with prostate cancer.
abstract: BACKGROUND
  Protein regulator of cytokinesis 1 (PRC1) has been reported to be implicated into the completion of cytokinesis and is dys-regulated in a cancer-specific manner. However, it roles in human prostate cancer (PCa) remain unclear. In the current study, we aimed to investigate the expression pattern of PRC1 and its clinical significance in this malignancy.
  
  
  METHODS
  PRC1 protein expression in human PCa and non-cancerous prostate tissues was detected by immunohistochemistry, which was validated by microarray-based Taylor data at mRNA level. Then, the associations of PRC1 expression with clinicopathological features and clinical outcome of PCa patients were statistically analyzed.
  
  
  RESULTS
  PRC1 expression in PCa tissues, at both mRNA and protein levels, were significantly higher than those in non-cancerous prostate tissues. In addition, the PCa patients with PRC1 overexpression more frequently had high Gleason score, advanced pathological stage, positive metastasis, short overall survival time and positive PSA failure than those with low Gleason score, early pathological stage, negative metastasis, long overall survival time and negative PSA failure (all P<0.05). Moreover, PRC1 expression was identified as an unfavorable prognostic factor of biochemical recurrence-free survival in PCa patients (P<0.001).
  
  
  CONCLUSIONS
  These findings suggest that the aberrant expression of PRC1 may predict biochemical recurrence in men with PCa highlighting its potential as a prognostic marker of this malignancy.
authors.affiliation: Department of Urology, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Luo
authors.affiliation: Department of Urology, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China; Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Qing-Biao
authors.initials: QB
authors.lastname: Chen
authors.affiliation: Department of Urology, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China.
authors.forename: Yue-Ping
authors.initials: YP
authors.lastname: Wan
authors.affiliation: Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.
authors.forename: Guan-Xing
authors.initials: GX
authors.lastname: Chen
authors.affiliation: Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Yang-Jia
authors.initials: YJ
authors.lastname: Zhuo
authors.affiliation: Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Zhi-Duan
authors.initials: ZD
authors.lastname: Cai
authors.affiliation: School of Marine Sciences, Sun Yat-sen University, Guangzhou 510275,China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.
authors.forename: Zhao-Dong
authors.initials: ZD
authors.lastname: Han
authors.affiliation: Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.
authors.forename: Yu-Xiang
authors.initials: YX
authors.lastname: Liang
authors.affiliation: Department of Urology, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China; Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China; Urology Key Laboratory of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510230, China. Electronic address: zhongwd2009@live.cn.
authors.forename: Wei-De
authors.initials: WD
authors.lastname: Zhong
mesh_terms: D000368:Aged; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D018797:Cell Cycle Proteins; C116662:PRC1 protein, human
keywords: Biochemical recurrence-free survival; Prostate cancer; Protein regulator of cytokinesis 1