title: Role of Oxidative Stress and Mitochondrial Dysfunction in Skeletal Muscle in Type 2 Diabetic Patients.
abstract: Type 2 diabetes can increase the risk of skeletal muscle dysfunction and, consequently, that of cardiovascular diseases, including coronary artery disease and stroke. It is also related to a reduced capacity for exercise, but the underlying mechanism is only partially understood. There are several factors that contribute to the development of skeletal muscle dysfunction, of which oxidative stress and mitochondrial dysfunction are among the most important. This review discusses the role of oxidative stress in the development and progression of skeletal and cardiac dysfunction associated with diabetes. It also provides an overview of the potential actions of antioxidants in general and mitochondria-targeted antioxidants in particular in the treatment of muscle dysfunction in type 2 diabetes.
authors.forename: Noelia
authors.initials: N
authors.lastname: Diaz-Morales
authors.forename: Susana
authors.initials: S
authors.lastname: Rovira-Llopis
authors.forename: Irene
authors.initials: I
authors.lastname: Escribano-Lopez
authors.forename: Celia
authors.initials: C
authors.lastname: Bañuls
authors.forename: Sandra
authors.initials: S
authors.lastname: Lopez-Domenech
authors.forename: Rosa
authors.initials: R
authors.lastname: Falcón
authors.forename: Arantxa Martinez
authors.initials: AM
authors.lastname: de Maranon
authors.forename: Eva
authors.initials: E
authors.lastname: Sola
authors.forename: Ana
authors.initials: A
authors.lastname: Jover
authors.forename: Ildefonso
authors.initials: I
authors.lastname: Roldan
authors.forename: Jose L
authors.initials: JL
authors.lastname: Diez
authors.affiliation: FISABIO- University Hospital Doctor Peset, Avda Gaspar Aguilar 90, 46017, Valencia, Spain. milagros.rocha@uv.es.
authors.forename: Milagros
authors.initials: M
authors.lastname: Rocha
authors.forename: Antonio
authors.initials: A
authors.lastname: Hernández-Mijares
authors.affiliation: FISABIO- University Hospital Doctor Peset, Avda Gaspar Aguilar 90, 46017, Valencia, Spain. victor.victor@uv.es.
authors.forename: Victor M
authors.initials: VM
authors.lastname: Víctor
mesh_terms: D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000975:Antioxidants