title: Kisspeptin Mediated Signaling in Cancer.
abstract: Research over the years has gradually and sequentially highlighted contributory role of hypothalamic- based kisspeptin-signaling axis as a major positive modulator of the neuroendocrinological reproductive axis in mammals. However, a series of landmark studies provided convincing evidence of role of this signaling in regulation of cancer development and progression. It is becoming progressively more understandable that loss or reduction of KISS1 expression in different human cancers correlates inversely with progression of tumor, metastasizing potential and survival. In this review we have attempted to provide an overview highlight of the most recent updates addressing metastasis- suppressing role of KISS1. We also summarize interplay of microRNA and KISS1 in cancer. The miRNA regulation of different genes is a rapidly expanding area of research however, the community lacks a deep understanding of miRNA regulation of KISS1. Recently, emerging laboratory findings have shown that KISS1 is transcriptionally controlled by TCF21 that is in turn regulated by miR-21. Therefore, there is an urgent need for further study of how miRNA directly or indirectly influences KISS1 at the posttranscriptional level. There is also a lack of evidence regarding natural agents that mediate upregulation or downregulation of KISS1. Increasing the knowledge of the KISS1/KISS1R signaling axis will be helpful in achieving personalized medicine.
authors.forename: Saima
authors.initials: S
authors.lastname: Jabeen
authors.forename: Muhammad Zahid
authors.initials: MZ
authors.lastname: Qureshi
authors.forename: Zeeshan
authors.initials: Z
authors.lastname: Javed
authors.forename: Muhammad Javed
authors.initials: MJ
authors.lastname: Iqbal
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ismail
authors.affiliation: Institute of Biomedical and Genetic Engineering (IBGE), G-9/1, Mauve Area, Islamabad. Ammadahmad638@yahoo.com.
authors.forename: Ammad Ahmad
authors.initials: AA
authors.lastname: Farooqi
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002986:Clinical Trials as Topic; D064593:Heterografts; D006801:Humans; D059648:Kisspeptins / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D009324:Naturopathy; D009369:Neoplasms / Q000188:drug therapy*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D059648:Kisspeptins