title: Holoprosencephaly and Pure Red Cell Aplasia in a Feline Leukaemia Virus-Positive Kitten.
abstract: A 9-month-old, female, domestic longhair cat with severe anaemia tested positive for feline leukaemia virus (FeLV) and was humanely destroyed and submitted for necropsy examination. Gross findings included a non-divided rostral telencephalon, consistent with semilobar holoprosencephaly. Histological examination of the bone marrow revealed an almost complete absence of erythroid precursor cells, consistent with pure red cell aplasia, and mild to moderate myelofibrosis. This case demonstrates a very unusual central nervous system defect, as well as an atypical presentation of pure red cell aplasia, in a FeLV-positive kitten.
authors.affiliation: Department of Biomedical Sciences, USA. Electronic address: tls93@cornell.edu.
authors.forename: T L
authors.initials: TL
authors.lastname: Southard
authors.affiliation: Department of Biomedical Sciences, USA.
authors.forename: J
authors.initials: J
authors.lastname: Rodriguez-Ramos Fernandez
authors.affiliation: Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
authors.forename: H
authors.initials: H
authors.lastname: Priest
authors.affiliation: Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
authors.forename: T
authors.initials: T
authors.lastname: Stokol
mesh_terms: D000818:Animals; D002415:Cats; D005260:Female; D016142:Holoprosencephaly / Q000662:veterinary* / Q000821:virology; D005256:Leukemia Virus, Feline; D012010:Red-Cell Aplasia, Pure / Q000662:veterinary* / Q000821:virology; D012192:Retroviridae Infections / Q000150:complications / Q000662:veterinary*
keywords: feline leukaemia virus; holoprosencephaly; myelofibrosis; pure red cell aplasia