title: Oxidative Stress Biomarkers and Left Ventricular Hypertrophy in Children with Chronic Kidney Disease.
abstract: Cardiovascular diseases remain the most frequent cause of morbidity and mortality in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between oxidative stress biomarkers and cardiovascular risk factors and left ventricular hypertrophy in children with CKD. Material and Methods. The studied group consisted of 65 patients aged 1.4-18.6 (mean 11.2) years with stages 1 to 5 CKD. Serum oxidized low-density lipoprotein (oxLDL), protein carbonyl group, creatinine, cystatin C, albumin, lipids, high-sensitivity C-reactive protein, intercellular adhesion molecule-1, insulin, plasma renin activity, and aldosterone levels were measured. Patients were divided into groups depending on CKD stage. Anthropometric measurements, ambulatory blood pressure (BP) measurements, and echocardiography with left ventricular mass (LVM) calculation were performed. Results. Serum oxLDL strongly correlated with creatinine (R = 0.246; p = 0.048), cystatin C (R = 0.346; p = 0.006), total cholesterol (R = 0.500; p < 0.001), triglycerides (R = 0.524; p < 0.001), low-density lipoprotein concentrations (R = 0.456; p < 0.001), and 24 hour BP values of systolic (R = 0.492; p = 0.002), diastolic (R = 0.515; p < 0.001), and mean arterial pressure (R = 0.537; p < 0.001). A significant correlation between oxLDL levels and LVM z-scores (R = 0.299; p = 0.016) was found. Conclusions. Hypertension and dyslipidemia correlated with lipid oxidation in children with CKD. oxLDLs seem to be valuable markers of oxidative stress in CKD patients, correlating with left ventricular hypertrophy.
authors.affiliation: Dialysis Unit, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Drożdż
authors.affiliation: Department of Pediatrics, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland.
authors.forename: Przemko
authors.initials: P
authors.lastname: Kwinta
authors.affiliation: Department of Clinical Biochemistry, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Sztefko
authors.affiliation: Department of Pediatric Cardiology, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Kordon
authors.affiliation: I Department of Cardiology, Interventional Cardiology and Hypertension, Jagiellonian University Medical College, 17 Kopernika Street, 31-501 Krakow, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Drożdż
authors.affiliation: Dialysis Unit, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Łątka
authors.affiliation: Dialysis Unit, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Miklaszewska
authors.affiliation: Dialysis Unit, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Zachwieja
authors.affiliation: Department of Pediatric Cardiology, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Rudziński
authors.affiliation: Dialysis Unit, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland.
authors.forename: Jacek Antoni
authors.initials: JA
authors.lastname: Pietrzyk
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D007223:Infant; D007231:Infant, Newborn; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D009929:Organ Size; D018384:Oxidative Stress; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein