title: Right Ventricular Function in Infants with Bronchopulmonary Dysplasia: Association with Respiratory Sequelae.
abstract: While cor pulmonale has been noted in infants with bronchopulmonary dysplasia (BPD), information on right ventricular (RV) function is limited.
  
  
  
  To assess RV function in infants with severe BPD and ascertain correlation with respiratory outcomes.
  
  
  
  We prospectively assessed RV function using tissue Doppler imaging (TDI), 2D fractional area change (FAC), M-mode tricuspid annular plane systolic excursion (TAPSE) and myocardial performance index (MPI) using echocardiography. Additionally, we compared RV function with preterm infants with no BPD.
  
  
  
  Eighteen preterm infants with severe BPD were enrolled at 36 weeks' gestation. Higher E/E' (r = 0.78, p < 0.0001) and lower FAC (r = 0.8, p < 0.0001) showed strong correlations with the subsequent duration of respiratory support. Correlations with TDI isovolumic velocity and Tei index were significant (-0.69, p = 0.002 and 0.58, p = 0.011, respectively). On comparison with infants with no BPD, TDI peak systolic velocities (0.06 ± 0.01 vs. 0.09 ± 0.01 m/s, p < 0.0001), peak isovolumic systolic velocities (0.05 ± 0.009 vs. 0.07 ± 0.008 m/s, p < 0.0001) and RV FAC (31 ± 4.7 vs. 36 ± 3.6%, p = 0.019) were significantly lower. Cardiac relaxation was impaired [higher TDI E/E' ratio (9.6 ± 1.8 vs. 5.2 ± 0.5, p < 0.0001) and higher RV MPI (0.33 ± 0.03 vs. 0.25 ± 0.03, p < 0.0001)].
  
  
  
  Impaired RV performance in the infants with severe BPD at 36 weeks' corrected gestation correlated with a longer duration of subsequent respiratory support.
authors.affiliation: Monash Newborn, Monash Children's Hospital, Monash Health, Melbourne, Vic., Australia.
authors.forename: Arvind
authors.initials: A
authors.lastname: Sehgal
authors.forename: Andra
authors.initials: A
authors.lastname: Malikiwi
authors.forename: Eldho
authors.initials: E
authors.lastname: Paul
authors.forename: Kenneth
authors.initials: K
authors.lastname: Tan
authors.forename: Samuel
authors.initials: S
authors.lastname: Menahem
mesh_terms: D001315:Australia; D001997:Bronchopulmonary Dysplasia / Q000150:complications*; D015150:Echocardiography, Doppler; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D011446:Prospective Studies; D013599:Systole; D014261:Tricuspid Valve / Q000000981:diagnostic imaging; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging*; D016278:Ventricular Function, Right