title: Chromosome condensation and decondensation during mitosis.
abstract: During eukaryotic cell division, nuclear chromatin undergoes marked changes with respect to shape and degree of compaction. Although already significantly compacted during interphase, upon entry into mitosis chromatin further condenses and individualizes to discrete chromosomes that are captured and moved independently by the mitotic spindle apparatus. Once segregated by the spindle, chromatin decondenses to re-establish its interphase structure competent for DNA replication and transcription. Although cytologically described a long time ago, the underlying molecular mechanisms of mitotic chromatin condensation and decondensation are still ill-defined. Here we summarize our current knowledge of mitotic chromatin restructuring and recent progress in the field.
authors.affiliation: Friedrich Miescher Laboratory of the Max Planck Society, Spemannstrasse 39, 72076 Tübingen, Germany. Electronic address: wolfram.antonin@tuebingen.mpg.de.
authors.forename: Wolfram
authors.initials: W
authors.lastname: Antonin
authors.affiliation: Georg August University Göttingen, GZMB, Applied Synthetic Biology Group, Justus-von-Liebig Weg 11, 37077 Göttingen, Germany. Electronic address: heinz.neumann@biologie.uni-goettingen.de.
authors.forename: Heinz
authors.initials: H
authors.lastname: Neumann
mesh_terms: D000818:Animals; D002843:Chromatin; D002875:Chromosomes / Q000378:metabolism*; D004261:DNA Replication; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism*; D007399:Interphase; D008938:Mitosis; D008941:Spindle Apparatus / Q000235:genetics
chemical_list: D002843:Chromatin