title: Kimura's disease: risk factors of recurrence and prognosis.
abstract: OBJECTIVE
  The aim of this study was to evaluate risk factors for recurrence and prognosis of Kimura's disease.
  
  
  METHODS
  In this study, 32 patients received surgery alone, surgery followed by steroids orally and surgery followed by radiotherapy respectively from 2003 to 2015 (male/female: 27/5, ages: 6-64 years). Retrieval of clinical data and follow-ups have been done. The clinical features used as variables include age, gender, location, multiplicity, laterality, size, duration, primary outbreak, smoking, eosinophils, systemic disease and remedies. Statistical analysis including Kaplan-Meier method, Fisher's exact test, Kruskal-Wallis H test, Mann-Whitney U-test and Cox proportional hazard regression model were performed with the SPSS 17.0. The threshold of statistical significance was set at P=0.05.
  
  
  RESULTS
  Median recurrence time was 29 months (2.42 years) after discharged and 56.3% patients relapsed. High recurrence rate was significantly associated with smoking habit (P=0.036). Patients who were diagnosed systemic disease (P=0.027) and were treated with surgery alone (P=0.025) or surgery followed by steroids orally (P=0.025) had short disease-free time. Furthermore, smoking habit (HR=3.383, 95% CI: 1.213-9.433, P=0.02), systemic disease (HR=4.462, 95% CI: 1.443-13.794, P=0.009), surgery alone (HR=4.668, 95% CI: 1.506-14.470, P=0.008) and surgery followed by steroids orally (HR=6.053, 95% CI: 1.330-27.556, P=0.02) were identified as risk factors for the prognosis of Kimura's disease.
  
  
  CONCLUSIONS
  Smoking habit, systemic diseases, surgery alone and surgery followed by steroids orally were associated with poor prognosis of Kimura's disease, and they might be prognostic markers of Kimura's disease.
authors.affiliation: Oncology Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province China.
authors.forename: Qing-Li
authors.initials: QL
authors.lastname: Chen
authors.affiliation: Oncology Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province China.
authors.forename: Srijana
authors.initials: S
authors.lastname: Dwa
authors.affiliation: Oncology Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province China.
authors.forename: Zhong-Cheng
authors.initials: ZC
authors.lastname: Gong
authors.affiliation: Oncology Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province China.
authors.forename: Keremu
authors.initials: K
authors.lastname: Abasi
authors.affiliation: Oncology Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province China.
authors.forename: Bin
authors.initials: B
authors.lastname: Ling
authors.affiliation: Oncology Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Oncology Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province China.
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Hu
authors.affiliation: Oncology Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province China.
authors.forename: Bo
authors.initials: B
authors.lastname: Shao
authors.affiliation: Oncology Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province China.
authors.forename: Zhao-Quan
authors.initials: ZQ
authors.lastname: Lin
keywords: Kimura’s disease; prognosis; radiotherapy; recurrence; smoking