title: Enantioselective Total Synthesis of Lycoposerramine-Z Using Chiral Phosphoric Acid Catalyzed Intramolecular Michael Addition.
abstract: A new enantioselective total synthesis of phlegmarine-type Lycopodium alkaloid lycoposerramine-Z (1) has been accomplished, using one-pot chemoselective sequential additions of two different Grignard reagents to the bis-Weinreb-amide intermediate and an efficient construction of the fully fuctionalized cyclohexanone intermediate with a chiral phosphoric acid catalyzed enantioselective intramolecular Michael addition.
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University , 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China.
authors.forename: Lan-De
authors.initials: LD
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University , 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China.
authors.forename: Lin-Rui
authors.initials: LR
authors.lastname: Zhong
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University , 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xi
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University , 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China.
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University , 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China.
authors.forename: Zhu-Jun
authors.initials: ZJ
authors.lastname: Yao