title: Development of a biphasic dissolution test for Deferasirox dispersible tablets and its application in establishing an in vitro-in vivo correlation.
abstract: In a biphasic dissolution medium, the integration of the in vitro dissolution of a drug in an aqueous phase and its subsequent partitioning into an organic phase is hypothesized to simulate the in vivo drug absorption. Such a methodology is expected to improve the probability of achieving a successful in vitro-in vivo correlation. Dissolution of Dispersible tablets of Deferasirox, a biopharmaceutics classification system type II compound, was studied in a biphasic dissolution medium using a flow-through dissolution apparatus coupled to a paddle apparatus. The experimental parameters associated with dissolution were optimized to discriminate between Deferasirox dispersible tablets of different formulations. The dissolution profiles obtained from this system were subsequently used to construct a level A in vitro-in vivo correlation.
authors.affiliation: Faculty of Pharmacy, The University of Jordan, Amman, Jordan.
authors.forename: Amal
authors.initials: A
authors.lastname: Al Durdunji
authors.affiliation: Faculty of Pharmacy, The University of Jordan, Amman, Jordan.
authors.forename: Hatim S
authors.initials: HS
authors.lastname: AlKhatib
authors.affiliation: Faculty of Pharmacy, The University of Jordan, Amman, Jordan. Electronic address: alghazam@ju.edu.jo.
authors.forename: Mutasim
authors.initials: M
authors.lastname: Al-Ghazawi
mesh_terms: D001565:Benzoates / Q000737:chemistry*; D001702:Biopharmaceutics / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D000077588:Deferasirox; D007408:Intestinal Absorption; D012995:Solubility; D013607:Tablets / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D001565:Benzoates; D013607:Tablets; D014230:Triazoles; D000077588:Deferasirox
keywords: Biphasic dissolution medium; Deferasirox; Flow-through apparatus; In vitro/in vivo correlations; Paddle apparatus