title: A review of the literature for intra-arterial chemotherapy used to treat retinoblastoma.
abstract: Retinoblastoma is a malignancy of the retina that usually presents before the age of 5 years. Sporadic retinoblastoma is most often unilateral and with no hereditary influence, whereas familial retinoblastoma presents unilaterally or bilaterally in conjunction with genetic inheritance. Several treatments have been attempted with the goals of saving the child's life, salvaging the eye, and preserving vision. Alternative methods including external beam radiation, systemic chemotherapy and focal therapies have been shown to be effective but carry a risk of enucleation and other complications proportional to the severity of the tumor. Selective intra-arterial chemotherapy for retinoblastoma began in 1988 in Japan and has emerged in the last 7 years in the United States as a feasible, effective and minimally invasive treatment option. We review the retinoblastoma treatment literature focusing on intra-arterial chemotherapy.
authors.affiliation: Division of Interventional Neuroradiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Wyse
authors.affiliation: Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: James T
authors.initials: JT
authors.lastname: Handa
authors.affiliation: Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Friedman
authors.affiliation: Division of Interventional Neuroradiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. msmit135@jhmi.edu.|Interventional Neuroradiology, Children's National Medical Center, Washington, DC, USA. msmit135@jhmi.edu.
authors.forename: Monica S
authors.initials: MS
authors.lastname: Pearl
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007261:Infusions, Intra-Arterial; D009880:Ophthalmic Artery; D015641:Radiography, Interventional; D019572:Retinal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012175:Retinoblastoma / Q000188:drug therapy* / Q000473:pathology; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents
keywords: Children; International classification; Intra-arterial chemotherapy; Melphalan; Reese–Ellsworth classification; Retinoblastoma; Systemic chemotherapy