title: Prospects of chitosan-based scaffolds for growth factor release in tissue engineering.
abstract: Tissue engineering is concerned about the rejuvenation and restoration of diseased and damages tissues/organs using man-made scaffolds that mimic the native environment of the cells. In recent years, a variety of biocompatible and biodegradable natural materials is employed for the fabrication of such scaffolds. Of these natural materials, chitosan is the most preferred one as it imitates the extracellular matrix (ECM) of the cells. Moreover, chitosan-based materials are pro-angiogenic and have antibacterial activity. These materials can be easily fabricated into the desired shape of the scaffolds that are suitable for tissue support and regeneration. Growth factors are small proteins/peptides that support and enhance the growth and differentiation of cells into a specific lineage. It has been observed that scaffolds capable of delivering growth factor promote tissue repair and regeneration at a faster rate when compared to scaffolds without growth factor. The present review focuses on the recent developments on chitosan-based scaffolds for the delivery of growth factors thereby improving and enhancing tissue regeneration.
authors.affiliation: Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai 603 103, India.
authors.forename: P R
authors.initials: PR
authors.lastname: Sivashankari
authors.affiliation: Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai 603 103, India. Electronic address: mprabaharan@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Prabaharan
mesh_terms: D000818:Animals; D018786:Bone Substitutes; D002454:Cell Differentiation; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage*; D012038:Regeneration; D044968:Regenerative Medicine; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D018786:Bone Substitutes; D004337:Drug Carriers; D036341:Intercellular Signaling Peptides and Proteins; D048271:Chitosan
keywords: Chitosan; Growth factor; Scaffolds; Tissue engineering; Wound healing