title: Third-generation antibody drug conjugates for cancer therapy--a balancing act.
authors.affiliation: Division of Cancer & Stem Cells, School of Medicine, City Hospital Campus, University of Nottingham, Hucknall Road, Nottingham, NG5 1PB, UK.
authors.forename: Mireille
authors.initials: M
authors.lastname: Vankemmelbeke
authors.affiliation: Division of Cancer & Stem Cells, School of Medicine, City Hospital Campus, University of Nottingham, Hucknall Road, Nottingham, NG5 1PB, UK.
authors.forename: Lindy
authors.initials: L
authors.lastname: Durrant
mesh_terms: D000080044:Ado-Trastuzumab Emtansine; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000378:metabolism; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D000079963:Brentuximab Vedotin; D004798:Enzymes / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006801:Humans; D018796:Immunoconjugates / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007167:Immunotherapy; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy; D008453:Maytansine / Q000031:analogs & derivatives / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy*; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D004798:Enzymes; D018796:Immunoconjugates; D004364:Pharmaceutical Preparations; D008453:Maytansine; D000079963:Brentuximab Vedotin; D000068878:Trastuzumab; D000080044:Ado-Trastuzumab Emtansine
keywords: ADC; antibody-targeted drug delivery; cancer therapy; payload; site-specific conjugation