title: Implications of plant glycans in the development of innovative vaccines.
abstract: Plant glycans play a central role in vaccinology: they can serve as adjuvants and/or delivery vehicles or backbones for the synthesis of conjugated vaccines. In addition, genetic engineering is leading to the development of platforms for the production of novel polysaccharides in plant cells, an approach with relevant implications for the design of new types of vaccines. This review contains an updated outlook on this topic and provides key perspectives including a discussion on how the molecular pharming field can be linked to the production of innovative glycan-based and conjugate vaccines.
authors.affiliation: a Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas , Universidad Autónoma de San Luis Potosí , Av. Dr. Manuel Nava 6, SLP , Mexico.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosales-Mendoza
authors.affiliation: a Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas , Universidad Autónoma de San Luis Potosí , Av. Dr. Manuel Nava 6, SLP , Mexico.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Salazar-González
authors.affiliation: b Plant Biotechnology, Faculty of Biology , University of Freiburg , Schaenzlestr. 1, Freiburg , Germany.
authors.forename: Eva L
authors.initials: EL
authors.lastname: Decker
authors.affiliation: b Plant Biotechnology, Faculty of Biology , University of Freiburg , Schaenzlestr. 1, Freiburg , Germany.|c BIOSS - Centre for Biological Signalling Studies , Freiburg , Germany.|d FRIAS - Freiburg Institute for Advanced Studies , Freiburg , Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Reski
mesh_terms: D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D004337:Drug Carriers / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D010944:Plants / Q000737:chemistry*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D004337:Drug Carriers; D011134:Polysaccharides
keywords: Molecular pharming; adjuvant; amylosomes; bacterial polysaccharides; conjugate vaccines; delta inulin; glyco-engineering; immunogenicity; pectin; starch