title: Modeling Chemotherapy-Induced Hair Loss: From Experimental Propositions toward Clinical Reality.
abstract: Chemotherapy-induced hair loss is one of the most devastating side effects of cancer treatment. To study the effects of chemotherapeutic agents on the hair follicle, a number of experimental models have been proposed. Yoon et al. report that transplantation of human scalp hair follicles onto chemotherapy-treated immunodeficient mice serves as an excellent in vivo model for chemotherapy-induced hair loss. Yoon et al. demonstrate that (i) the response of human hair follicles grafted onto immunodeficient mice to cyclophosphamide resembles the key features of the chemotherapy-induced hair loss seen in patients with cancer and (ii) this human in vivo model for chemotherapy-induced hair loss is closer to clinical reality than to any earlier models. Undoubtedly, this model will serve as a valuable tool for analyses of the mechanisms that underlie this devastating side effect of anti-cancer therapy.
authors.affiliation: Centre for Skin Sciences, Faculty of Life Sciences, University of Bradford, Bradford, UK; Departments of Dermatology, Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA. Electronic address: v.a.botchkarev@bradford.ac.uk.
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Botchkarev
authors.affiliation: Departments of Dermatology, Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA. Electronic address: drsharov@bu.edu.
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Sharov
mesh_terms: D000505:Alopecia / Q000139:chemically induced* / Q000473:pathology*; D000818:Animals; D003520:Cyclophosphamide / Q000009:adverse effects*; D018859:Hair Follicle / Q000187:drug effects*; D006801:Humans
chemical_list: D003520:Cyclophosphamide