title: A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.
abstract: Over the past decade, there has been growing interest in the Notch signalling pathway within the breast cancer field. This interest stemmed initially from the observation that Notch signalling is aberrantly activated in breast cancer and its effects on various cellular processes including proliferation, apoptosis, and cancer stem cell activity. However more recently, elevated Notch signalling has been correlated with therapy resistance in oestrogen receptor-positive breast cancer. As a result, inhibiting Notch signalling with therapeutic agents is being explored as a promising treatment option for breast cancer patients.
authors.affiliation: Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Acar
authors.affiliation: Breast Biology Group, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
authors.forename: Bruno M
authors.initials: BM
authors.lastname: Simões
authors.affiliation: Breast Biology Group, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Clarke
authors.affiliation: Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Keith
authors.initials: K
authors.lastname: Brennan