title: Hearing Preservation after Low-dose Gamma Knife Radiosurgery of Vestibular Schwannomas.
abstract: The objective of the retrospective study was to evaluate the factors associated with hearing preservation after low-dose Gamma Knife radiosurgery (GKS) of vestibular schwannomas performed according to the modern standards. From January 2005 to September 2010, 141 consecutive patients underwent such treatment in Tokyo Women's Medical University. Mean marginal dose was 11.9 Gy (range, 11-12 Gy). The doses for the brain stem, cranial nerves (V, VII, and VIII), and cochlea were kept below 14 Gy, 12 Gy, and 4 Gy, respectively. Out of the total cohort, 102 cases with at least 24 months follow-up were analyzed. Within the median follow-up of 56 months (range, 24-99 months) the crude tumor growth control was 92% (94 cases), whereas its actuarial rate at 5 years was 93%. Out of 49 patients with serviceable hearing on the side of the tumor before GKS, 28 (57%) demonstrated its preservation at the time of the last follow-up. No one evaluated factor, namely Gardner-Robertson hearing class before irradiation, Koos tumor stage, extension of the intrameatal part of the neoplasm up to fundus, nerve of tumor origin, presence of cystic changes in the neoplasm, and cochlea dose demonstrated statistically significant association with preservation of the serviceable hearing after radiosurgery. In conclusion, GKS of vestibular schwannomas performed according to the modern standards of treatment permits to preserve serviceable hearing on the side of the tumor in more than half of the patients. The actual causes of hearing deterioration after radiosurgery remain unclear.
authors.affiliation: Department of Neurosurgery, Tokyo Women's Medical University.
authors.forename: Ayako
authors.initials: A
authors.lastname: Horiba
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hayashi
authors.forename: Mikhail
authors.initials: M
authors.lastname: Chernov
authors.forename: Takakazu
authors.initials: T
authors.lastname: Kawamata
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Okada
mesh_terms: D005500:Follow-Up Studies; D006309:Hearing; D034381:Hearing Loss / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D009464:Neuroma, Acoustic / Q000601:surgery*; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods; D012189:Retrospective Studies; D016896:Treatment Outcome