title: Effects of oral exposure to silver nanoparticles on the sperm of rats.
abstract: It has been demonstrated that exposure to silver nanoparticles (AgNPs) can induce toxicological effects in rodents. In this study, we investigated whether sub-chronic oral exposure to different doses of polyvinil pyrrolidone (PVP)-coated AgNPs (PVP-AgNPs) (50, 100 and 200mg/kg/day) could induce harmful effects on epididymal sperm rat parameters. Sperm motility, viability and morphology were examined. Moreover, a histological evaluation of testis and epididymis was also performed. High doses of PVP-AgNPs showed higher sperm morphology abnormalities, while a progressive, but not significant effect, was observed in other sperm parameters. The current results suggest that oral sub-chronic exposure to PVP-AgNPs induces slight toxicological effects in sperm rat parameters.
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain; Physiology Unit, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Lafuente
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain; Biochemistry Unit, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Garcia
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain; Physiology Unit, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Blanco
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain; Physiology Unit, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain.
authors.forename: D J
authors.initials: DJ
authors.lastname: Sánchez
authors.affiliation: Department of Pathology, University Hospital Joan XXIII, Tarragona, Catalonia, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Sirvent
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Domingo
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain; Biochemistry Unit, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain. Electronic address: mariamercedes.gomez@urv.cat.
authors.forename: M
authors.initials: M
authors.lastname: Gómez
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004822:Epididymis / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D011205:Povidone / Q000737:chemistry / Q000633:toxicity*; D017207:Rats, Sprague-Dawley; D012834:Silver / Q000737:chemistry / Q000633:toxicity*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects* / Q000502:physiology; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects
chemical_list: D012834:Silver; D011205:Povidone
keywords: Epididymis; Reproductive toxicity; Silver nanoparticles; Sperm