title: The molecular mechanisms between metabolic syndrome and breast cancer.
abstract: Metabolic syndrome, which is extremely common in developed and some developing countries, is a clustering of at least three of five of the following medical conditions: abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density lipoprotein levels. It has been proved that there is a strong association between metabolic syndrome and breast cancer. Metabolic syndrome could increase the risk of breast cancer and influence the prognosis of the breast cancer patients. Some characteristic of metabolic syndrome such as obesity and lack of physical exercise are all risk factors for developing breast cancer. The metabolic syndrome mainly include obesity, type 2 diabetes, hypercholesterolemia and nonalcoholic fatty liver disease, and each of them impacts the risk of breast cancer and the prognosis of the breast cancer patients in different ways. In this Review, we focus on recently uncovered aspects of the immunological and molecular mechanisms that are responsible for the development of this highly prevalent and serious disease. These studies bring new insight into the complex associations between metabolic syndrome and breast cancer and have led to the development of novel therapeutic strategies that might enable a personalized approach in the management of this disease.
authors.affiliation: Department of General Surgery (Breast, Thyroid and Vascular Suerery), Daping Hospital of the Third Military Medical University, Chongqing, 400042, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of General Surgery (Breast, Thyroid and Vascular Suerery), Daping Hospital of the Third Military Medical University, Chongqing, 400042, China.
authors.forename: Ya-yuan
authors.initials: YY
authors.lastname: Wen
authors.affiliation: Department of General Surgery (Breast, Thyroid and Vascular Suerery), Daping Hospital of the Third Military Medical University, Chongqing, 400042, China.
authors.forename: Zhi-rong
authors.initials: ZR
authors.lastname: Li
authors.affiliation: Department of General Surgery (Breast, Thyroid and Vascular Suerery), Daping Hospital of the Third Military Medical University, Chongqing, 400042, China.
authors.forename: Dong-lin
authors.initials: DL
authors.lastname: Luo
authors.affiliation: Department of General Surgery (Breast, Thyroid and Vascular Suerery), Daping Hospital of the Third Military Medical University, Chongqing, 400042, China. Electronic address: xiaohua_zhang2012@126.com.
authors.forename: Xiao-hua
authors.initials: XH
authors.lastname: Zhang
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism; D050171:Dyslipidemias / Q000150:complications / Q000378:metabolism; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000150:complications* / Q000378:metabolism*; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000378:metabolism; D012307:Risk Factors
keywords: Breast cancer; Metabolic syndrome; Nonalcoholic fatty liver disease; Obesity; Type 2 diabetes