title: Single-strand gap repair involves both RecF and RecBCD pathways.
abstract: Homologous recombination repairs discontinuities in DNA including single-strand gaps (SSGs) and double-strand breaks (DSBs). This commentary describes how the RecBCD and RecF pathways might be exchangeable for the repair of their respective DSB and SSG canonical substrates. In particular, I will discuss how the RecBCD pathway could engage in the repair of an SSG even when the latter is not associated with a DSB.
authors.affiliation: Cancer Research Center of Marseille, Team DNA Damage Tolerance, CNRS, UMR7258, 13009, Marseille, France. vincent.pages@inserm.fr.|Inserm, U1068, 13009, Marseille, France. vincent.pages@inserm.fr.|Institut Paoli-Calmettes, 13009, Marseille, France. vincent.pages@inserm.fr.|Aix-Marseille University, UM 105, 13284, Marseille, France. vincent.pages@inserm.fr.
authors.forename: Vincent
authors.identifier: http://orcid.org/0000-0002-3059-2903
authors.initials: V
authors.lastname: Pagès
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D004277:DNA, Single-Stranded / Q000235:genetics* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D043211:Exodeoxyribonuclease V / Q000378:metabolism*; D011995:Recombination, Genetic; D013379:Substrate Specificity
chemical_list: D001426:Bacterial Proteins; D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins; C066218:recF protein, Bacteria; D043211:Exodeoxyribonuclease V
keywords: Broken chromosomes; DNA damage; DNA repair; DNA replication; Double-strand break; Homologous recombination; RecA; RecBCD; RecF; Single-strand gap