title: Emerging Roles of Protein Deamidation in Innate Immune Signaling.
abstract: Protein deamidation has been considered a nonenzymatic process associated with protein functional decay or "aging." Recent studies implicate protein deamidation in regulating signal transduction in fundamental biological processes, such as innate immune responses. Work investigating gammaherpesviruses and bacterial pathogens indicates that microbial pathogens deploy deamidases or enzyme-deficient homologues (pseudoenzymes) to induce deamidation of key signaling components and evade host immune responses. Here, we review studies on protein deamidation in innate immune signaling and present several imminent questions concerning the roles of protein deamidation in infection and immunity.
authors.affiliation: Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California, USA.
authors.forename: Junhua
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California, USA.
authors.forename: Simin
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California, USA pinghui.feng@med.usc.edu.
authors.forename: Pinghui
authors.initials: P
authors.lastname: Feng
mesh_terms: D000818:Animals; D002384:Catalysis; D016207:Cytokines / Q000096:biosynthesis; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D011506:Proteins / Q000378:metabolism*; D059748:Proteolysis; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D011506:Proteins; D051192:Receptors, Pattern Recognition; D018168:Receptors, Retinoic Acid