title: Etirinotecan pegol for the treatment of breast cancer.
abstract: BACKGROUND
  Advanced breast cancer is incurable for most patients with limited therapeutic options. As such, there is a critical need for new and novel agents that lack cross-resistance and mitigate overlapping toxicities.
  
  
  METHODS
  This review examines etirinotecan pegol as a promising new agent for the treatment of refractory metastatic breast cancer. Etirinotecan pegol is the first topoisomerase I inhibitor with a novel design: a long-acting polymer conjugate of irinotecan molecularly engineered to concentrate in vascularized tumors and provide sustained circulation time of SN38 for prolonged tumor cell exposure. Etirinotecan pegol pharmacology is reviewed in this paper along with safety and efficacy data from preclinical and clinical trials. In the phase II advanced breast cancer setting, etirinotecan pegol provided promising activity, which was maintained in poor prognostic subgroups, with low rates of neutropenia and neuropathy - issues plaguing our currently available agents.
  
  
  CONCLUSIONS
  Etirinotecan pegol demonstrates anti-tumor activity and improved tolerability in patients with refractory metastatic breast cancer. As a novel topoisomerase I inhibitor in breast cancer, etirinotecan pegol holds great therapeutic potential, allowing the challenge of resistance in the advanced disease setting to be addressed.
authors.affiliation: a Department of Medical Oncology , Ramon y Cajal University Hospital , Madrid , Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: López-Miranda
authors.affiliation: a Department of Medical Oncology , Ramon y Cajal University Hospital , Madrid , Spain.|b Department of Medical Oncology , Vall d'Hebron Institute of Oncology , Barcelona , Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Cortés
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D005260:Female; D006576:Heterocyclic Compounds, 4 or More Rings / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D011092:Polyethylene Glycols / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D059004:Topoisomerase I Inhibitors / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D006576:Heterocyclic Compounds, 4 or More Rings; D059004:Topoisomerase I Inhibitors; D011092:Polyethylene Glycols; C581703:etirinotecan pegol
keywords: Advanced or metastatic breast cancer; Chemotherapy-resistant; Etirinotecan pegol; Polymer-based medicine