title: Interplay between Superoxide Dismutase, Glutathione Peroxidase, and Peroxisome Proliferator Activated Receptor Gamma Polymorphisms on the Risk of End-Stage Renal Disease among Han Chinese Patients.
abstract: Background. Single nucleotide polymorphisms (SNPs) of antioxidants, including superoxide dismutase 2 (SOD2) and glutathione peroxidase 1 (GPX1), play an important role in the risk for cancer and metabolic disorders. However, little is known regarding the effect of antioxidant SNPs on renal events. Methods. We prospectively enrolled multicenter patients with end-stage renal disease (ESRD) and those without chronic kidney disease (CKD) of Han Chinese origin, with SOD2 (Val16Ala), GPX1 (Pro197Leu), and PPAR-γ (Pro12Ala, C161T) genotyped. Multiple regression analyses were conducted to evaluate the significant risk determinants for ESRD. Results. Compared to ESRD patients, non-CKD subjects were more likely to have T allele at SOD2 Val16Ala (p = 0.036) and CC genotype at PPAR-γ Pro12Ala (p = 0.028). Regression analysis showed that TT genotype of SOD2 Val16Ala conferred significantly lower ESRD risk among patients without diabetes (odds ratio 0.699; p = 0.018). GPX1 SNP alone did not alter the risk. We detected significant interactions between SNPs including PPAR-γ Pro12Ala, C161T, and GPX1 regarding the risk of ESRD. Conclusion. This is the first and largest study on the association between adverse renal outcomes and antioxidant SNPs among Han Chinese population. Determination of SOD2 and PPAR-γ SNPs status might assist in ESRD risk estimation.
authors.affiliation: Department of Medicine, National Taiwan University Hospital Jinshan Branch, New Taipei City, Taiwan; Graduate Institute of Toxicology, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road, Section 1, 10051 Taipei, Taiwan.
authors.forename: Chia-Ter
authors.initials: CT
authors.lastname: Chao
authors.affiliation: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, No. 17 Xu-Zhou Road, 10055 Taipei, Taiwan.
authors.forename: Yen-Ching
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Graduate Institute of Toxicology, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road, Section 1, 10051 Taipei, Taiwan; Department of Integrated Diagnostics & Therapeutics, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 10002 Taipei, Taiwan.
authors.forename: Chih-Kang
authors.initials: CK
authors.lastname: Chiang
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 10002 Taipei, Taiwan.
authors.forename: Jenq-Wen
authors.initials: JW
authors.lastname: Huang
authors.affiliation: Department of Emergency Medicine, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 10002 Taipei, Taiwan.
authors.forename: Cheng-Chung
authors.initials: CC
authors.lastname: Fang
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 10002 Taipei, Taiwan.
authors.forename: Chen-Chih
authors.initials: CC
authors.lastname: Chang
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 10002 Taipei, Taiwan; Department of Geriatric Medicine and Gerontology, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 10002 Taipei, Taiwan.
authors.forename: Chung-Jen
authors.initials: CJ
authors.lastname: Yen
mesh_terms: D044466:Asian People / Q000235:genetics*; D015331:Cohort Studies; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D047495:PPAR gamma / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000235:genetics*; D000094765:Glutathione Peroxidase GPX1; D000099156:Superoxide Dismutase 2
chemical_list: D005979:Glutathione Peroxidase; D047495:PPAR gamma; D013482:Superoxide Dismutase; D000094765:Glutathione Peroxidase GPX1; D000099156:Superoxide Dismutase 2; C000722067:GPX1 protein, human