title: Autosomal dominant polycystic kidney disease and coronary artery dissection or aneurysm: a systematic review.
abstract: OBJECTIVE
  Autosomal dominant polycystic kidney disease (ADPKD) has been associated with cardiovascular abnormalities such as intracranial and aortic aneurysms.
  
  
  OBJECTIVE
  To systematically review the case reports and case series of ADPKD patients with coronary artery dissection or aneurysm. Evidence review Systematic review registration number: CRD42015015723.
  
  
  METHODS
  MEDLINE, Web of Science and OpenGrey, reference lists of studies.
  
  
  METHODS
  Published case reports and case series.
  
  
  METHODS
  Two parties analyzed the studies. Disagreements were solved by consensus or by a third party.
  
  
  BACKGROUND
  none. Findings The reports of 23 patients (22 from 17 studies--six with coronary artery dissection and 16 with coronary artery aneurysm--and one with coronary dissection) were analyzed and reported here. Most patients were symptomatic. Coronary dissection showed female and left descending anterior artery predominance, features similar to non-ADPKD patients, but a median diagnostic age below expected (41 vs. 50 years old). Coronary aneurysms had male and right coronary artery predominance but lower median diagnostic age (44 years old) and higher rate of multiple vessel affection than reported for non-ADPKD patients.
  
  
  CONCLUSIONS
  Clinical disparities may suggest a different mechanism of aneurysm formation compared to the population without ADPKD. Nevertheless, lack of access to data of one patient and text of one article limited our conclusions. Coronary aneurysms and dissections represent a source of coronary syndromes and death in ADPKD. Mutation of ADPKD-related genes may predispose to coronary abnormalities, especially aneurysms. Further analysis regarding this association is necessary.
authors.affiliation: a Department of Medicine , Centro Hospitalar Lisboa Norte , Lisbon , Portugal ;
authors.forename: Joana Briosa
authors.initials: JB
authors.lastname: Neves
authors.affiliation: a Department of Medicine , Centro Hospitalar Lisboa Norte , Lisbon , Portugal ;|b Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine , University of Lisbon, Portugal and Clinical Pharmacology Unit, Instituto de Medicina Molecular , Lisbon , Portugal ;
authors.forename: Filipe Brogueira
authors.initials: FB
authors.lastname: Rodrigues
authors.affiliation: c Department of Nephrology and Renal Transplantation , Centro Hospitalar Lisboa Norte , Lisbon , Portugal.
authors.forename: José António
authors.initials: JA
authors.lastname: Lopes
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000209:etiology*; D003323:Coronary Aneurysm / Q000209:etiology*; D005260:Female; D006801:Humans; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications*
keywords: Autosomal dominant polycystic kidney disease; coronary aneurysm; coronary dissection; systematic review