title: Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds.
abstract: Actinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancient underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia with a focus on the biological activity of the obtained strains and the metabolite dereplication of one active strain. Streptomyces genera isolates from moonmilk speleothem demonstrated antibacterial and antifungal activities. Some of the strains were able to inhibit the growth of pathogenic Candida albicans.
authors.forename: Denis V
authors.initials: DV
authors.lastname: Axenov-Gribanov
authors.affiliation: Irkutsk State University, Institute of Biology, Irkutsk, Russia.
authors.forename: Denis V
authors.initials: DV
authors.lastname: Axenov-Gibanov
authors.affiliation: Irkutsk State University, Institute of Biology, Irkutsk, Russia.
authors.forename: Irina V
authors.initials: IV
authors.lastname: Voytsekhovskaya
authors.affiliation: Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany.
authors.forename: Bogdan T
authors.initials: BT
authors.lastname: Tokovenko
authors.affiliation: Irkutsk State University, Institute of Biology, Irkutsk, Russia.
authors.forename: Eugeniy S
authors.initials: ES
authors.lastname: Protasov
authors.affiliation: Irkutsk State University, Institute of Biology, Irkutsk, Russia.
authors.forename: Stanislav V
authors.initials: SV
authors.lastname: Gamaiunov
authors.affiliation: Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany.
authors.forename: Yuriy V
authors.initials: YV
authors.lastname: Rebets
authors.affiliation: Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany.|Universität des Saarlandes-Pharmazeutische Biotechnologie, Saarbrucken, Germany.
authors.forename: Andriy N
authors.initials: AN
authors.lastname: Luzhetskyy
authors.affiliation: Irkutsk State University, Institute of Biology, Irkutsk, Russia.
authors.forename: Maxim A
authors.initials: MA
authors.lastname: Timofeyev
mesh_terms: D039903:Actinobacteria / Q000302:isolation & purification / Q000378:metabolism*; D000935:Antifungal Agents / Q000378:metabolism* / Q000494:pharmacology; D002176:Candida albicans / Q000254:growth & development; D059552:Caves; D060106:Lakes; D012800:Siberia; D014871:Water Microbiology
chemical_list: D000935:Antifungal Agents