title: Pacinian Corpuscles in a Cervical Chondrocutaneous Remnant: A Case Report and Update of Pacinian Corpuscles.
abstract: Cervical chondrocutaneous remnants are congenital, benign, and rare neck masses. We present here for the first time the immunohistochemical profile of Pacinian corpuscles present in cervical chondrocutaneous remnants, removed, and localized in the territory of the second branchial arch from a 5-year-old girl. We have performed immunohistochemistry to analyze these sensory corpuscles using a battery of antibodies including markers for each corpuscle constituent. The central axon was immunoreactive for neurofilaments, neuron-specific enolase, and neural cell adhesion molecule; the Schwann-related cells forming the inner core displayed immunoreactivity for S100 protein, vimentin, and neural cell adhesion molecule; the outer core and the capsule were positive for vimentin, epithelial membrane antigen, and glucose transporter 1. These results are discussed in topographical differences. Moreover, a brief update about the structure, protein composition, and development of Pacinian corpuscles was performed.
authors.affiliation: *Departamento de Morfología y Biología Celular, Grupo SINPOS, Universidad de Oviedo, Oviedo, Spain; †Servicio de Anatomía Patológica, Hospital Universitario Donostia, San Sebastián, Spain; ‡Servicio de Cirugía Pediátrica, Hospital Universitario Donostia, San Sebastián, Spain; §Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Universidad de Oviedo, Oviedo, Spain; ¶Servicio de Cirugía Maxilofacial, Hospital Universitario Central de Asturias, Oviedo, Spain; ‖Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain; and **Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago de Chile (J. Feito is now with Servicio de Anatomía Patológica, Complejo Universitario de Salamanca, Spain).
authors.forename: Jorge
authors.initials: J
authors.lastname: Feito
authors.forename: José L
authors.initials: JL
authors.lastname: Ramos-García
authors.forename: Ángel
authors.initials: Á
authors.lastname: Gago
authors.forename: Juan L
authors.initials: JL
authors.lastname: Cobo
authors.forename: Olivia
authors.initials: O
authors.lastname: García-Suárez
authors.forename: Luis M
authors.initials: LM
authors.lastname: Junquera
authors.forename: José A
authors.initials: JA
authors.lastname: Vega
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001934:Branchial Region / Q000002:abnormalities*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010141:Pacinian Corpuscles / Q000002:abnormalities*
chemical_list: D015415:Biomarkers