title: Association between genetic polymorphism in NFKB1 and NFKBIA and coronary artery disease in a Chinese Han population.
abstract: OBJECTIVE
  Prior studies have demonstrated NF-κB plays an important role in the development and progression of inflammatory diseases. The aim of this study was to investigate whether promoter polymorphisms in NFKB1 and NFKBIA gene are associated with coronary artery disease (CAD) in a Chinese Han population.
  
  
  METHODS
  A total of 1140 Han CAD patients and 1156 Han control subjects were genotyped for 4 single-nucleotide polymorphisms (SNPs) in the promoter region of NFKBIA gene (rs3138053, rs2233406, rs2233409) and NFKB1 gene (-94 ins/del ATTG, rs28362491) by using the TaqMan SNP genotyping assays, and then NFKBIA haplotype blocks were reconstructed according to our genotyping data.
  
  
  RESULTS
  For total, men, and women, the distribution of genotypes, alleles of rs3138053, rs2233406, rs2233409 and haplotype polymorphisms showed no significant difference between CAD cases and controls. None of the studied NFKBIA SNPs were associated with CAD. For total, men, and women, there was significant difference in the distribution of the genotypes (P=0.001, P=0.024, P= 0.022) and alleles (P=0.001, P=0.012, P=0.031) of rs28362491 in CAD cases and controls. For total, men, and women, the rs28362491 was associated with increased risk of CAD in a recessive model after adjustment for covariates (OR=1.505, 95% CI 1.190 to 1.903, P=0.001; OR=1.469, 95% CI 1.082-1.993, P=0.014; OR=1.622, 95% CI 1.118 to 2.352, P=0.011, respectively).
  
  
  CONCLUSIONS
  In our study, the -94 ins/del ATTG polymorphism in NFKB1 promoter is associated with CAD susceptibility in Chinese Han population, providing a new insight into the genetics of CAD in Chinese Han population.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi, China; Department of Cardiology, People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi, China; Xinjiang Key Laboratory of Cardiovascular Disease ResearchUrumqi, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Lai
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi, China; Xinjiang Key Laboratory of Cardiovascular Disease ResearchUrumqi, China.
authors.forename: Qingjie
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi, China; Xinjiang Key Laboratory of Cardiovascular Disease ResearchUrumqi, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi, China; Xinjiang Key Laboratory of Cardiovascular Disease ResearchUrumqi, China.
authors.forename: Yitong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi, China; Xinjiang Key Laboratory of Cardiovascular Disease ResearchUrumqi, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi, China; Xinjiang Key Laboratory of Cardiovascular Disease ResearchUrumqi, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhai
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease ResearchUrumqi, China; Clinical Research Institute of Xinjiang Medical UniversityUrumqi, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease ResearchUrumqi, China; Clinical Research Institute of Xinjiang Medical UniversityUrumqi, China.
authors.forename: Bangdang
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi, China; Xinjiang Key Laboratory of Cardiovascular Disease ResearchUrumqi, China.
authors.forename: Yining
authors.initials: Y
authors.lastname: Yang
keywords: Chinese Han population; Coronary artery disease; NFKB1 and NFKBIA polymorphism