title: Clinical research activity in periodontal medicine: a systematic mapping of trial registers.
abstract: The primary aim of the study was to systematically map registration records on periodontal medicine in clinical trial registers. The secondary aim was to assess the evolution of periodontal medicine in clinical periodontal research as a whole.
  
  
  
  We searched all registration records related to periodontology in the World Health Organization International Clinical Trials Registry Platform. For registration records classified in the field of periodontal medicine, we assigned the 2015 MeSH(®) term for the most precisely corresponding systemic condition.
  
  
  
  Fifty-seven systemic conditions have been hypothesized to be linked with periodontal diseases, covering nearly 2% of the diseases indexed in MeSH. In addition to diabetes, cardiovascular disease or preterm birth, other systemic conditions have been the subject of registration records, such as anaemia, liver diseases, dyspepsia or ankylosing spondylitis. A trend towards increasing diversification of systemic conditions has appeared over time. About a third of registration records in clinical periodontal research deals with periodontal medicine.
  
  
  
  Periodontal medicine now constitutes an important part of clinical periodontal research. Research activity in periodontal medicine has grown continuously since the early 2000s, and exploration of registers gives a useful up-to-date snapshot of this constantly evolving field of research.
authors.affiliation: Dental Faculty, Department of Anatomical Sciences and Radiology, Paul Sabatier University, Toulouse University Hospital, Toulouse, France.|CNRS 5273, UMR STROMALab, University of Toulouse UPS, INSERM U1031, EFS Pyrenees - Mediterranean, Toulouse, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Monsarrat
authors.affiliation: University of Lille, Dental faculty, Place de Verdun, F-59000 Lille, France.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Blaizot
authors.affiliation: Dental Faculty, Department of Biological Sciences, Paul Sabatier University, Toulouse University Hospital, Toulouse, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Kémoun
authors.affiliation: Faculty of Medicine, Paris Descartes University, Paris, France.|INSERM UMR-1153, Paris, France.|Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
authors.forename: Philippe
authors.initials: P
authors.lastname: Ravaud
authors.affiliation: Dental Faculty, Department of Epidemiology and Public Health, Paul Sabatier University, Toulouse University Hospital, Toulouse, France.|INSERM U1027, Paul Sabatier University, Toulouse, France.
authors.forename: Cathy
authors.initials: C
authors.lastname: Nabet
authors.affiliation: Dental Faculty, Department of Epidemiology and Public Health, Paul Sabatier University, Toulouse University Hospital, Toulouse, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Sixou
authors.affiliation: Dental Faculty, Department of Epidemiology and Public Health, Paul Sabatier University, Toulouse University Hospital, Toulouse, France.|Division of Oral Health and Society, Faculty of dentistry, McGill University, Montreal, QC, Canada.
authors.forename: Jean-Noel
authors.initials: JN
authors.lastname: Vergnes
mesh_terms: D002318:Cardiovascular Diseases; D003920:Diabetes Mellitus; D005882:Gingival Diseases; D006801:Humans; D010510:Periodontal Diseases; D012042:Registries
keywords: clinical trials; periodontal diseases; periodontal medicine; periodontitis; systematic review