title: Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels.
abstract: Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor--dipeptidyl peptidase 4 (DPP4)--is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.
authors.affiliation: Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Widagdo
authors.affiliation: Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: V Stalin
authors.initials: VS
authors.lastname: Raj
authors.affiliation: Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Debby
authors.initials: D
authors.lastname: Schipper
authors.affiliation: Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Kimberley
authors.initials: K
authors.lastname: Kolijn
authors.affiliation: Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Geert J L H
authors.initials: GJLH
authors.lastname: van Leenders
authors.affiliation: Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
authors.forename: Berend J
authors.initials: BJ
authors.lastname: Bosch
authors.affiliation: IRTA, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
authors.forename: Albert
authors.initials: A
authors.lastname: Bensaid
authors.affiliation: UAB, Centre de Recerca en Sanitat Animal (CReSA), Unitat Mixta IRTA-UAB, Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.|Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
authors.forename: Joaquim
authors.initials: J
authors.lastname: Segalés
authors.affiliation: Department of Pathology, University of Veterinary Medicine, Hannover, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Baumgärtner
authors.affiliation: Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.|Artemis One Health, Utrecht, The Netherlands.|Center for Infection Medicine and Zoonoses Research (RIZ), University of Veterinary Medicine, Hannover, Germany.
authors.forename: Albert D M E
authors.initials: ADME
authors.lastname: Osterhaus
authors.affiliation: Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Marion P
authors.initials: MP
authors.lastname: Koopmans
authors.affiliation: Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Judith M A
authors.initials: JMA
authors.lastname: van den Brand
authors.affiliation: Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands b.haagmans@erasmusmc.nl.
authors.forename: Bart L
authors.initials: BL
authors.lastname: Haagmans
mesh_terms: D000818:Animals; D002162:Camelus; D018352:Coronavirus Infections / Q000635:transmission / Q000821:virology*; D018819:Dipeptidyl Peptidase 4 / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D065207:Middle East Respiratory Syndrome Coronavirus / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011991:Receptors, Virus / Q000235:genetics* / Q000378:metabolism; D020545:Respiratory Mucosa / Q000378:metabolism* / Q000821:virology*; D014779:Virus Replication
chemical_list: D012333:RNA, Messenger; D011991:Receptors, Virus; D018819:Dipeptidyl Peptidase 4