title: Retrospective multicentre observational study on clinical management and treatment of different types of status epilepticus in clinical practice.
abstract: BACKGROUND
  Status epilepticus (SE) is a neurological emergency associated with significant mortality and morbidity. We analyse characteristics of this entity in our population.
  
  
  METHODS
  Data from electronic medical records of adults diagnosed with SE were collected retrospectively from 5 hospitals over 4 years.
  
  
  RESULTS
  Data reflected 84 episodes of SE in 77 patients with a mean age of 60.3 years. Of this sample, 52.4% had a previous history of epilepsy. Status classification: 47.6% tonic-clonic, 21.4% complex partial, 17.9% partial motor, 6% partial simple, 3.6% myoclonic, and 3.6% subtle SE. Based on the duration of the episode, SE was defined in this study as early stage (up to 30min) in 13.1%, established (30-120min) in 20.2%, refractory (more than 120min) in 41.7%, and super-refractory (episodes continuing or recurring after more than 24h of anaesthesia) in 13.1%. Ten patients (11.9%) died when treatment failed to control SE. The cumulative percentage of success achieved was 8.3% with the first treatment, 27.3% for the second, 48.7% for the third, 58.2% for the fourth, 70.1% for the fifth, 80.8% for the sixth, 83.2% for the seventh, and 84.4% for the eighth.
  
  
  CONCLUSIONS
  In our study, we found that SE did not respond to treatment within 2h in approximately half the cases and 11.9% of the patients died without achieving seizure control, regardless of the type of status. Half the patients responded by the third treatment but some patients needed as many as 8 treatments to resolve seizures. Using large registers permitting analysis of the different types and stages of SE is warranted.
authors.affiliation: Hospital Universitario Infanta Cristina, Parla, Madrid, España. Electronic address: masuncion.morena@salud.madrid.org.
authors.forename: M A
authors.initials: MA
authors.lastname: de la Morena Vicente
authors.affiliation: Hospital Universitario Infanta Cristina, Parla, Madrid, España.
authors.forename: J J
authors.initials: JJ
authors.lastname: Granizo Martínez
authors.affiliation: Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: Ojeda Ruiz de Luna
authors.affiliation: Hospital Universitario del Henares, Coslada, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Peláez Hidalgo
authors.affiliation: Hospital Universitario del Tajo, Aranjuez, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Luque Alarcón
authors.affiliation: Hospital Universitario del Sureste, Arganda del Rey, Madrid, España.
authors.forename: F J
authors.initials: FJ
authors.lastname: Navacerrada Barrero
authors.affiliation: Harrogate District Hospital, Reino Unido.
authors.forename: S
authors.initials: S
authors.lastname: Al Hussayni Husseini
authors.affiliation: Hospital Universitario del Henares, Coslada, Madrid, España.
authors.forename: E
authors.initials: E
authors.lastname: García Cobos
authors.affiliation: Hospital Universitario Infanta Cristina, Parla, Madrid, España.
authors.forename: L
authors.initials: L
authors.lastname: Ballesteros Plaza
authors.affiliation: Hospital Universitario Infanta Elena, Valdemoro, Madrid, España.
authors.forename: G
authors.initials: G
authors.lastname: de Las Casas Cámara
authors.affiliation: Hospital Universitario Infanta Cristina, Parla, Madrid, España.
authors.forename: I
authors.initials: I
authors.lastname: Viudez Jiménez
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013226:Status Epilepticus / Q000188:drug therapy* / Q000401:mortality; D013997:Time Factors
chemical_list: D000927:Anticonvulsants
keywords: Complex partial; Estatus epileptico; Parcial complejo; Parcial motor; Partial motor; Prognosis; Pronóstico; Status epilepticus; Tonic-clonic; Tratamiento; Treatment; Tónico-clonico