title: Preservation of Biospecimens at Ambient Temperature: Special Focus on Nucleic Acids and Opportunities for the Biobanking Community.
abstract: Several approaches to the preservation of biological materials at ambient temperature and the relative impact on sample stability and degradation are reviewed, with a focus on nucleic acids. This appraisal is undertaken within the framework of biobank risk, quality management systems, and accreditation, with a view to assessing how best to apply ambient temperature sample storage to ensure stability, reduce costs, improve handling logistics, and increase the efficiency of biobank procedures.
authors.affiliation: 1 Biomatrica, Inc. , San Diego, California.
authors.forename: Rolf
authors.initials: R
authors.lastname: Muller
authors.affiliation: 2 Integrated Biobank of Luxembourg , Luxembourg, Luxembourg .
authors.forename: Fay
authors.initials: F
authors.lastname: Betsou
authors.affiliation: 3 Assurex Health , Mason, Ohio.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Barnes
authors.affiliation: 4 Damar Research Scientists , Damar, Cupar Muir, United Kingdom .
authors.forename: Keith
authors.initials: K
authors.lastname: Harding
authors.affiliation: 5 Imagene , Genopole Campus 1, Evry, France .|6 Université de Bordeaux Segalen, Institut Bergonié , Bordeaux, France .
authors.forename: Jacques
authors.initials: J
authors.lastname: Bonnet
authors.affiliation: 2 Integrated Biobank of Luxembourg , Luxembourg, Luxembourg .
authors.forename: Olga
authors.initials: O
authors.lastname: Kofanova
authors.affiliation: 7 Department of Molecular and Cellular Biology, University of California , Davis, California.
authors.forename: John H
authors.initials: JH
authors.lastname: Crowe
mesh_terms: D018070:Biological Specimen Banks / Q000458:organization & administration*; D009696:Nucleic Acids; D011309:Preservation, Biological / Q000379:methods*; D011786:Quality Control; D013696:Temperature
chemical_list: D009696:Nucleic Acids