title: Tissue Distribution and Transfer to Eggs of Ingested α-Hexabromocyclododecane (α-HBCDD) in Laying Hens (Gallus domesticus).
abstract: The aim of the current study was to describe the fate of ingested α-hexabromocyclododecane (α-HBCDD) in laying hens. Individuals were exposed to two dietary concentrations of α-HBCDD (50 and 5 ng g(-1) feed) for 18 or 11 weeks followed by a 7-week decontamination period. The results show that no isomerization of α- to β- or γ-HBCDD forms occurred, whereas OH-HBCDD was identified as a product of α-HBCDD metabolism. Irrespective of the level of feed contamination, estimates of steady-state accumulation ratios were 5.2, 3.6, and 9.2 and half-lives were estimated at 17.4, 22.8, and 35.3 days in egg yolk, liver tissue, and abdominal fat, respectively. The steady-state carry-over rate to eggs was 22.9%. Thus, α-HBCDD ingested by laying hens is readily transferred to eggs and significantly accumulates in adipose tissue.
authors.affiliation: INRA, Université de Lorraine, URAFPA, USC 340 , 54500 Vandoeuvre-lès-Nancy, France.|INRA, UR 83 Recherches Avicoles , 37380 Nouzilly, France.|ITAVI, Centre INRA de Tours , 37380 Nouzilly, France.
authors.forename: Elena
authors.initials: E
authors.lastname: Dominguez-Romero
authors.affiliation: LUNAM Université, Oniris, LABERCA, INRA, USC 1329 , 44307 Nantes Cedex, France.
authors.forename: Ronan
authors.initials: R
authors.lastname: Cariou
authors.affiliation: LUNAM Université, Oniris, LABERCA, INRA, USC 1329 , 44307 Nantes Cedex, France.
authors.forename: Elsa
authors.initials: E
authors.lastname: Omer
authors.affiliation: LUNAM Université, Oniris, LABERCA, INRA, USC 1329 , 44307 Nantes Cedex, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Marchand
authors.affiliation: LUNAM Université, Oniris, LABERCA, INRA, USC 1329 , 44307 Nantes Cedex, France.
authors.forename: Gaud
authors.initials: G
authors.lastname: Dervilly-Pinel
authors.affiliation: LUNAM Université, Oniris, LABERCA, INRA, USC 1329 , 44307 Nantes Cedex, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Le Bizec
authors.affiliation: ITAVI, Centre INRA de Tours , 37380 Nouzilly, France.
authors.forename: Angélique
authors.initials: A
authors.lastname: Travel
authors.affiliation: INRA, Université de Lorraine, URAFPA, USC 340 , 54500 Vandoeuvre-lès-Nancy, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Jondreville
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002645:Chickens / Q000378:metabolism*; D004530:Egg Yolk / Q000737:chemistry / Q000378:metabolism; D004531:Eggs / Q000032:analysis*; D005260:Female; D005506:Food Contamination / Q000032:analysis; D006842:Hydrocarbons, Brominated / Q000032:analysis / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D006842:Hydrocarbons, Brominated; C089796:hexabromocyclododecane
keywords: accumulation; egg; hexabromocyclododecane; laying hen; transfer