title: PtW/MoS2 hybrid nanocomposite for electrochemical sensing of H2O2 released from living cells.
abstract: Hydrogen peroxide (H2O2) as an important reactive oxygen species (ROS) is reactive and potentially harmful to cells, causing oxidation of lipids, proteins and DNA. Herein, we report a PtW/MoS2 hybrid nanocomposite with ultrasensitive and highly specific response for the detection of H2O2 released from breast cancer 4T1 cells. Upon exposure to 5 nM of H2O2, the electrochemical response is still visible. This PtW/MoS2 hybrid nanocomposite could be facilely synthesized through in-situ growth of PtW nanocrystals on the surface of MoS2 nanosheets. The incorporation of PtW nanocrystals and MoS2 nanosheets in conjunction with each other to form hybrid nanocomposite improves the selective interaction of H2O2 with sensing material surface, and further increases the sensitivity and selectivity of sensor.
authors.affiliation: Materials Genome Institute, Shanghai University, Shanghai 200444, China; Department of Chemistry, Shanghai University, Shanghai 200444, China.
authors.forename: Lilian
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Materials Genome Institute, Shanghai University, Shanghai 200444, China; State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China. Electronic address: zhangyuan@shu.edu.cn.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Xu
authors.affiliation: Materials Genome Institute, Shanghai University, Shanghai 200444, China.
authors.forename: Weijia
authors.initials: W
authors.lastname: Wen
authors.affiliation: State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Chemistry, Shanghai University, Shanghai 200444, China. Electronic address: xujiaqiang@shu.edu.cn.
authors.forename: Jiaqiang
authors.initials: J
authors.lastname: Xu
mesh_terms: D015374:Biosensing Techniques; D045744:Cell Line, Tumor; D006801:Humans; D006861:Hydrogen Peroxide / Q000302:isolation & purification*; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D008982:Molybdenum / Q000737:chemistry; D053761:Nanocomposites / Q000737:chemistry*; D010084:Oxidation-Reduction; D010984:Platinum / Q000737:chemistry
chemical_list: D010984:Platinum; D008982:Molybdenum; D006861:Hydrogen Peroxide
keywords: H(2)O(2); Hybrid nanocomposite; Living cell; MoS(2); PtW