title: Mucosal healing in inflammatory bowel disease: Maintain or de-escalate therapy.
abstract: In the past decade, thanks to the introduction of biologic therapies, a new therapeutic goal, mucosal healing (MH), has been introduced. MH is the expression of an arrest of disease progression, resulting in minor hospitalizations, surgeries, and prolonged clinical remission. MH may be achieved with several therapeutic strategies reaching success rates up to 80% for both, ulcerative colitis (UC) and Crohn's disease (CD). Various scoring systems for UC and for the transmural CD, have been proposed to standardize the definition of MH. Several attempts have been undertaken to de-escalate therapy once MH is achieved, thus, reducing the risk of adverse events. In this review, we analysed the available studies regarding the achievement of MH and the subsequent treatment de-escalation according to disease type and administered therapy, together with non-invasive markers proposed as predictors for relapse. The available data are not encouraging since de-escalation after the achievement of MH is followed by a high number of clinical relapses reaching up to 50% within one year. Unclear is also another question, in case of combination therapies, which drug is more appropriate to stop, in order to guarantee a durable remission. Predictors of unfavourable outcome such as disease extension, perianal disease, or early onset disease appear to be inadequate to foresee behaviour of disease. Further studies are warranted to investigate the role of histologic healing for the further course of disease.
authors.affiliation: Marcello Cintolo, Giuseppe Costantino, Walter Fries, Clinical Unit for Chronic Bowel Disorders, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Cintolo
authors.affiliation: Marcello Cintolo, Giuseppe Costantino, Walter Fries, Clinical Unit for Chronic Bowel Disorders, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Costantino
authors.affiliation: Marcello Cintolo, Giuseppe Costantino, Walter Fries, Clinical Unit for Chronic Bowel Disorders, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
authors.forename: Socrate
authors.initials: S
authors.lastname: Pallio
authors.affiliation: Marcello Cintolo, Giuseppe Costantino, Walter Fries, Clinical Unit for Chronic Bowel Disorders, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
authors.forename: Walter
authors.initials: W
authors.lastname: Fries
keywords: Biological therapy; Crohn’s disease; De-escalation; Deep remission; Discontinuation; Immunosuppressors; Mucosal healing; Ulcerative colitis