title: Spirocyclic Sultam and Heterobiaryl Synthesis through Rh-Catalyzed Cross-Dehydrogenative Coupling of N-Sulfonyl Ketimines and Thiophenes or Furans.
abstract: A useful approach is developed for the synthesis of various structurally interesting spirocyclic sultams and heterobiaryls using a cross-dehydrogenative coupling strategy that features high atom and step economy. This method employs [Cp*RhCl2]2 as a catalyst and N-sulfonylimine, a weak coordinating group, as an efficient directing group to assist C-H activation. A number of the coupled products were converted into interesting molecules through further synthetic transformations.
authors.affiliation: College of Pharmacy, Third Military Medical University , Chongqing 400038, China.
authors.forename: Shu-Tao
authors.initials: ST
authors.lastname: Mei
authors.affiliation: College of Pharmacy, Third Military Medical University , Chongqing 400038, China.
authors.forename: Hong-Wen
authors.initials: HW
authors.lastname: Liang
authors.affiliation: College of Pharmacy, Third Military Medical University , Chongqing 400038, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Teng
authors.affiliation: College of Pharmacy, Third Military Medical University , Chongqing 400038, China.
authors.forename: Nan-Jin
authors.initials: NJ
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Third Military Medical University , Chongqing 400038, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shuai
authors.affiliation: College of Pharmacy, Third Military Medical University , Chongqing 400038, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: College of Pharmacy, Third Military Medical University , Chongqing 400038, China.
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
authors.affiliation: College of Pharmacy, Third Military Medical University , Chongqing 400038, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Wei