title: The efficacy and safety of posterior scleral reinforcement using genipin cross-linked sclera for macular detachment and retinoschisis in highly myopic eyes.
abstract: To evaluate the efficacy and safety of posterior scleral reinforcement (PSR) using genipin cross-linked sclera as the material to treat macular detachment and retinoschisis, both without macular hole, in highly myopic eyes.
  
  
  
  Twenty-one patients with highly myopic eyes (24 eyes) with macular detachment and retinoschisis were treated sequentially with genipin cross-linked PSR and were followed for at least 1 year after surgery. The best-corrected visual acuity (BCVA), spherical equivalent (SE) power, axial length (AL), optical coherence tomography, and the complications were evaluated.
  
  
  
  The mean SE decreased from -13.81±4.67 D preoperatively to -9.64±4.86 D postoperatively, while the improvement in the logMAR BCVA values was from 1.24±0.57 before surgery to 1.03±0.57 after surgery. The preoperative AL (29.73±2.31 mm) was decreased (28.08±2.08 mm) after the operation. The retina in 21 eyes (87.5%) was successful reattached and the macular detachment was significantly decreased in two eyes; a macular hole occurred in one eye.
  
  
  
  For at least a 1 year period of follow-up, PSR with genipin cross-linked sclera was safe and effective to treat macular detachment and retinoschisis in high myopia when a macular hole was not present. The reinforcement effect tended to be stabilised and maintained for 6 months after treatment.
authors.affiliation: The Eye Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Shuang-Qian
authors.initials: SQ
authors.lastname: Zhu
authors.affiliation: The Eye Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Lin-Yan
authors.initials: LY
authors.lastname: Zheng
authors.affiliation: The Eye Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: An-Peng
authors.initials: AP
authors.lastname: Pan
authors.affiliation: The Eye Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: A-Yong
authors.initials: AY
authors.lastname: Yu
authors.affiliation: The Eye Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Qin-Mei
authors.initials: QM
authors.lastname: Wang
authors.affiliation: The Eye Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: An-Quan
authors.initials: AQ
authors.lastname: Xue
mesh_terms: D000269:Adhesives; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D039823:Iridoids / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000150:complications* / Q000503:physiopathology; D009887:Ophthalmoscopy; D012029:Refraction, Ocular; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D041441:Retinoschisis / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D012189:Retrospective Studies; D012590:Sclera / Q000601:surgery*; D012591:Scleral Buckling / Q000379:methods*; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D000269:Adhesives; D039823:Iridoids; C007834:genipin
keywords: Macula; Retina; Treatment Surgery