title: The impact of Helicobacter pylori eradication on serum hepcidin-25 level and iron parameters in patients with iron deficiency anemia.
abstract: OBJECTIVE
  The aim of this study was to evaluate the efficacy of bismuth-based quadruple regiment as a first-line treatment for Helicobacter pylori (H. pylori) eradication in patients with unexplained iron deficiency anemia (IDA). The serum hepcidin-25, iron, ferritin levels and total iron-binding capacity were evaluated at baseline and after H. pylori eradication in order to assess whether H. pylori eradication plays a role in IDA related to H. pylori infection.
  
  
  METHODS
  The study included 80 patients with unexplained IDA and H. pylori infection. All patients received pantoprazole (40 mg b.i.d.), bismuth subcitrate (120 mg q.i.d.), tetracycline (500 mg q.i.d.) and metronidazole (500 mg t.i.d.) over 14 days as H. pylori eradication regimen. In all patients, blood samples were drawn at baseline and 1 month after eradication therapy. In all patients, serum hepcidin-25 levels were determined by using commercially available enzyme-linked immunosorbent assay kits.
  
  
  RESULTS
  There was an improvement in hemoglobin, iron, total iron-binding capacity and ferritin values after H. pylori eradication in all subjects. Serum hepcidin-25 levels significantly decreased after H. pylori eradication (p < 0.001).
  
  
  CONCLUSIONS
  Gastric H. pylori infection is a common cause of IDA of unknown origin in adult patients. Our results provide evidence indicating that hepcidin level decreases after successful H. pylori eradication with improvement in IDA.
authors.affiliation: Department of Gastroenterology, Keçiören Education and Training Hospital, Keçiören, Ankara, Turkey. ferda-sapmaz@hotmail.com.
authors.forename: Ferdane
authors.initials: F
authors.lastname: Sapmaz
authors.affiliation: Department of Gastroenterology, Keçiören Education and Training Hospital, Keçiören, Ankara, Turkey.
authors.forename: Sebahat
authors.initials: S
authors.lastname: Başyiğit
authors.affiliation: Department of Gastroenterology, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.
authors.forename: İsmail Hakkı
authors.initials: İH
authors.lastname: Kalkan
authors.affiliation: Department of Biochemistry, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.
authors.forename: Üçler
authors.initials: Ü
authors.lastname: Kısa
authors.affiliation: Department of Gastroenterology, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.
authors.forename: Engin Eren
authors.initials: EE
authors.lastname: Kavak
authors.affiliation: Department of Gastroenterology, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.
authors.forename: Sefa
authors.initials: S
authors.lastname: Güliter
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D058491:Bacterial Load / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000187:drug effects / Q000302:isolation & purification; D064451:Hepcidins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; D064451:Hepcidins; C545475:hepcidin 25, human; D007501:Iron