title: Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes.
abstract: In this work, a comparison between two different preparation methods for the improvement of dissolution rate of an antifungal agent is presented. Poly(ε-caprolactone) (PCL) electrospun fibers and β-cyclodextrin (β-CD) complexes, which were produced via an electrospinning process and an inclusion complexation method, respectively, were addressed for the treatment of fungal infections. Voriconazole (VRCZ) drug was selected as a model drug. PCL nanofibers were characterized on the basis of morphology while phase solubility studies for β-CDs complexes were performed. Various concentrations (5, 10, 15 and 20 wt %) of VRCZ were loaded to PCL fibers and β-CD inclusions to study the in vitro release profile as well as in vitro antifungal activity. The results clearly indicated that all formulations showed an improved VRCZ solubility and can inhibit fungi proliferation.
authors.affiliation: Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece. siafpan@gmail.com.
authors.forename: Panoraia I
authors.initials: PI
authors.lastname: Siafaka
authors.affiliation: School of Pharmacy, Department of Pharmaceutical Technology, Istanbul Medipol University, Beykoz, 34810 Istanbul, Turkey. nustundag@medipol.edu.tr.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Üstündağ Okur
authors.affiliation: Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece. mariza_mone@hotmail.com.
authors.forename: Mariza
authors.initials: M
authors.lastname: Mone
authors.affiliation: Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece. spiretta@hotmail.com.
authors.forename: Spyridoula
authors.initials: S
authors.lastname: Giannakopoulou
authors.affiliation: School of Pharmacy, Department of Microbiology, Istanbul Medipol University, Beykoz, 34810 Istanbul, Turkey. ser@medipol.edu.tr.
authors.forename: Sevda
authors.initials: S
authors.lastname: Er
authors.affiliation: Department of Physics, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece. etpavlid@auth.gr.
authors.forename: Eleni
authors.initials: E
authors.lastname: Pavlidou
authors.affiliation: Pharmathen S.A, Dervenakion Str. 6, 153 51 Attiki, Greece. ekaravas@pharmathen.gr.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Karavas
authors.affiliation: Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece. dbic@chem.auth.gr.
authors.forename: Dimitrios N
authors.initials: DN
authors.lastname: Bikiaris
mesh_terms: D000284:Administration, Oral; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D057139:Nanofibers / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry; D065819:Voriconazole / Q000008:administration & dosage* / Q000494:pharmacology; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D004337:Drug Carriers; D011091:Polyesters; D047392:beta-Cyclodextrins; C016240:polycaprolactone; D065819:Voriconazole
keywords: PCL; antifungal; fibers; inclusion complexation; voriconazole drug