title: The spectrum of histopathological changes encountered in pancreatectomy specimens after neoadjuvant chemoradiation, including subtle and less-well-recognised changes.
abstract: Preoperative (neoadjuvant) chemoradiation therapy/treatment (NCRT) is emerging as an important treatment modality in borderline resectable pancreatic ductal adenocarcinoma (PDAC). The constellation of histopathological changes secondary to chemoradiation is diverse and has been well documented, particularly in other gastrointestinal organs such as the oesophagus and colorectum. However, the histological changes specific to the pancreas have not been fully characterised and described. This review aims to provide a detailed catalogue of histological features associated with NCRT-treated PDAC and highlight any subtle, less-recognised changes.
authors.affiliation: Departments of Pathology, Laboratory Medicine Program and *Medical Oncology, University Health Network and University of Toronto, Toronto, Canada.
authors.forename: Sangeetha N
authors.initials: SN
authors.lastname: Kalimuthu
authors.affiliation: Departments of Pathology, Laboratory Medicine Program and *Medical Oncology, University Health Network and University of Toronto, Toronto, Canada.
authors.forename: Stefano
authors.initials: S
authors.lastname: Serra
authors.affiliation: Departments of Pathology, Laboratory Medicine Program and *Medical Oncology, University Health Network and University of Toronto, Toronto, Canada.
authors.forename: Neesha
authors.initials: N
authors.lastname: Dhani
authors.affiliation: Departments of Pathology, Laboratory Medicine Program and *Medical Oncology, University Health Network and University of Toronto, Toronto, Canada.
authors.forename: Runjan
authors.initials: R
authors.lastname: Chetty
mesh_terms: D001706:Biopsy; D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D059186:Chemoradiotherapy, Adjuvant; D006801:Humans; D020360:Neoadjuvant Therapy; D010179:Pancreas / Q000473:pathology* / Q000601:surgery; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy
keywords: CARCINOMA; CHEMOTHERAPY; PANCREAS