title: Mannose Receptor Is Required for Optimal Induction of Vaccine-Induced T-Helper Type 17 Cells and Resistance to Blastomyces dermatitidis Infection.
abstract: We investigated how innate sensing by the mannose receptor (MR) influences the development of antifungal immunity. We demonstrate that MR senses mannan on the surface of attenuated Blastomyces dermatitidis vaccine yeast and that MR(-/-) mice demonstrate impaired vaccine immunity against lethal experimental blastomycosis, compared with wild-type control mice. Using naive Blastomyces-specific transgenic CD4(+) T cells, we found that MR regulates differentiation of naive T cells into T-helper type 17 (Th17) effector cells, which are essential in vaccine immunity against systemic dimorphic fungi. Thus, MR regulates differentiation of Th17 cells and is required to induce vaccine immunity against lethal pulmonary blastomycosis.
authors.affiliation: Departments of Pediatrics.
authors.forename: Huafeng
authors.initials: H
authors.lastname: Wang
authors.affiliation: Departments of Pediatrics.
authors.forename: Vanessa
authors.initials: V
authors.lastname: LeBert
authors.affiliation: Departments of Pediatrics.
authors.forename: Mengyi
authors.initials: M
authors.lastname: Li
authors.affiliation: Departments of Pediatrics.
authors.forename: Tassanee
authors.initials: T
authors.lastname: Lerksuthirat
authors.affiliation: Departments of Pediatrics.
authors.forename: Kevin
authors.initials: K
authors.lastname: Galles
authors.affiliation: Departments of Pediatrics Department of Internal Medicine Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison.
authors.forename: Bruce
authors.initials: B
authors.lastname: Klein
authors.affiliation: Departments of Pediatrics.
authors.forename: Marcel
authors.initials: M
authors.lastname: Wüthrich
mesh_terms: D000818:Animals; D001758:Blastomyces / Q000276:immunology*; D001759:Blastomycosis / Q000276:immunology*; D002473:Cell Wall / Q000276:immunology; D060467:Disease Resistance; D005260:Female; D005657:Fungal Vaccines / Q000276:immunology*; D000071497:Immunogenicity, Vaccine; D020381:Interleukin-17 / Q000378:metabolism; D037181:Lectins, C-Type / Q000378:metabolism*; D038041:Lymphopoiesis; D008297:Male; D008351:Mannans / Q000378:metabolism; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism*; D008810:Mice, Inbred C57BL; D011956:Receptors, Cell Surface / Q000378:metabolism*; D058504:Th17 Cells / Q000166:cytology / Q000276:immunology*
chemical_list: D005657:Fungal Vaccines; D020381:Interleukin-17; D037181:Lectins, C-Type; D008351:Mannans; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface
keywords: T-cell differentiation; fungi; mannose receptor; vaccine immunity