title: Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery.
abstract: An innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation. One MN patch can quickly reduce the blood-sugar levels (BGLs) of chemically induced type-1 diabetic mice and stabilize BGLs at a reduced level for over 10 h.
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Yanqi
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Jicheng
authors.initials: J
authors.lastname: Yu
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Nhu-Y
authors.initials: NY
authors.lastname: Nguyen
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Glenn M
authors.initials: GM
authors.lastname: Walker
authors.affiliation: Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
authors.forename: John B
authors.initials: JB
authors.lastname: Buse
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000378:metabolism* / Q000473:pathology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D051379:Mice; D009339:Needles; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: diabetes; drug delivery; microneedles; pancreatic cells; physiological signals