title: What are the next breakthroughs in the management of acute intracerebral hemorrhage?
abstract: The impact of acute therapy for intracerebral hemorrhage is far behind that for acute ischemic stroke. Potential breakthroughs in the management of acute intracerebral hemorrhage are presented. To prevent early hematoma growth, acute blood pressure lowering, emergent hemostatic therapy, and minimally invasive surgery with topical thrombolysis have been attempted. Anti-inflammatory and neuroprotective pharmacotherapies may attenuate perihematomal edema as a surrogate marker for the inflammatory response and improve clinical outcomes after intracerebral hemorrhage. Hyperacute modification of vital parameters, early seizure control, early rehabilitation, and neuroregenerative therapy are other promising strategies in the foreseeable future.
authors.affiliation: Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan toyoda@ncvc.go.jp.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Toyoda
authors.affiliation: Division of Stroke Care Unit, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Koga
authors.affiliation: Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Sato
mesh_terms: D002543:Cerebral Hemorrhage / Q000628:therapy*; D019468:Disease Management; D006801:Humans; D020521:Stroke / Q000628:therapy*
keywords: Acute stroke; blood pressure; hemorrhagic stroke; hemostatic therapy; minimally invasive surgery