title: Exploiting Copper Redox for (19)F Magnetic Resonance-Based Detection of Cellular Hypoxia.
abstract: We report a pair of fluorinated, redox-active copper complexes for potential use as (19)F MRI contrast agents for detecting cellular hypoxia. Trifluorinated Cu(II) ATSM-F3 displays the appropriate redox potential for selective accumulation in hypoxic cells and a completely quenched (19)F NMR signal that is "turned on" following reduction to Cu(I). Incubation of cancer cells with CuATSM-F3 resulted in a selective detection of (19)F signal in cells grown under hypoxic conditions.
authors.affiliation: Department of Chemistry, The University of Texas at Austin , 105 E. 24th St Stop A5300, Austin, Texas 78712, United States.
authors.forename: Da
authors.initials: D
authors.lastname: Xie
authors.affiliation: Department of Chemistry, The University of Texas at Austin , 105 E. 24th St Stop A5300, Austin, Texas 78712, United States.
authors.forename: Tyler L
authors.initials: TL
authors.lastname: King
authors.affiliation: Department of Chemistry, The University of Texas at Austin , 105 E. 24th St Stop A5300, Austin, Texas 78712, United States.
authors.forename: Arnab
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: Department of Chemistry, The University of Texas at Austin , 105 E. 24th St Stop A5300, Austin, Texas 78712, United States.
authors.forename: Vikraant
authors.initials: V
authors.lastname: Kohli
authors.affiliation: Department of Chemistry, The University of Texas at Austin , 105 E. 24th St Stop A5300, Austin, Texas 78712, United States.
authors.forename: Emily L
authors.initials: EL
authors.lastname: Que
mesh_terms: D015687:Cell Hypoxia / Q000502:physiology*; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D066235:Fluorine-19 Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D008024:Ligands; D061986:MCF-7 Cells; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D009942:Organometallic Compounds; D013882:Thiosemicarbazones; C089548:copper (II) diacetyl-di(N(4)-methylthiosemicarbazone); D003300:Copper