title: Update on the effect of estradiol in postmenopause women with Alzheimer's disease: a systematic review.
abstract: Estradiol (E2) has been used in the treatment of Alzheimer's disease (AD) for many years but with various responses. Evidence from clinical studies, randomized clinical trials (RCTs), and observational studies further underscores the importance of E2 in postmenopause women diagnosed with AD. The purpose of this article is to review all clinical trials to date focusing on the E2 in AD patients to explore the evidence regarding use of E2 in AD treatments. To achieve this objective, clinical studies regarding E2 levels in AD patients and RCTs assessing AD treatment in postmenopause women were identified through searches of MEDLINE, The Cochrane Library, EMBASE, Web of Science, Ovid, and Google Scholar. E2 has demonstrated good therapeutic effectiveness in AD patients, however, further larger scale, double-blind RCTs are required before a definitive conclusion can be reached and the results need to be compared with other drugs. This update reviews the newest clinical information regarding the role of E2 in postmenopause women with AD. To our knowledge, this is the only systematic review of this area.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhong Shan Road, Dalian City, 116011, People's Republic of China.|Department of Physiology, Dalian Medical University, 9 Western District, Lvshun South Road, Dalian City, 116044, People's Republic of China.
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Lan
authors.affiliation: Department of Physiology, Dalian Medical University, 9 Western District, Lvshun South Road, Dalian City, 116044, People's Republic of China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Zou
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhong Shan Road, Dalian City, 116011, People's Republic of China.
authors.forename: Changfu
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhong Shan Road, Dalian City, 116011, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhong Shan Road, Dalian City, 116011, People's Republic of China. yinghuixucn@163.com.
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Physiology, Dalian Medical University, 9 Western District, Lvshun South Road, Dalian City, 116044, People's Republic of China. lishao89@hotmail.com.
authors.forename: Shao
authors.initials: S
authors.lastname: Li
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004958:Estradiol / Q000627:therapeutic use*; D006801:Humans; D017698:Postmenopause / Q000502:physiology*; D012737:Sex Factors
chemical_list: D004958:Estradiol
keywords: Alzheimer’s disease; Estradiol; Postmenopause women; Treatment