title: Evaluation of intrauterine insemination practices: a 1-year prospective study in seven French assisted reproduction technology centers.
abstract: OBJECTIVE
  To determine the best practices of intrauterine insemination with the partner's fresh sperm.
  
  
  METHODS
  Prospective multicenter observational study.
  
  
  METHODS
  Assisted reproduction technology (ART) centers.
  
  
  METHODS
  Seven hundred and seven patients entering the program, regardless of age or cause of infertility.
  
  
  METHODS
  Intrauterine insemination by standard procedures.
  
  
  METHODS
  Effect of patient characteristics (duration of infertility, indications, age, parity, body mass index, semen parameters) as well as IUI parameters on delivery rates per couple or per attempt.
  
  
  RESULTS
  The overall live birth rate was 11.4% per cycle, varying from 8.4% to 17.6% between centers. The main differences in practice that had a statistically significant impact on the delivery rate were the use of gonadotropin-releasing hormone (GnRH) antagonists (15.2% with versus 9.4% without) and the number of mature recruited follicles (9.4% for one versus 15.2% for two).
  
  
  CONCLUSIONS
  Our results indicate that the use of GnRH antagonists has a positive effect on the delivery rate, especially in the multifollicular stimulations that are required when women are older than 27 years.
authors.affiliation: Médecine de la Reproduction, CHU Toulouse, Toulouse, France.
authors.forename: Oriana
authors.initials: O
authors.lastname: Monraisin
authors.affiliation: Biologie de la Reproduction-CECOS Groupe Hospitalier Pellegrin-Maternité, Bordeaux, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Chansel-Debordeaux
authors.affiliation: Centre d'Assistance Médicale à la Procréation Bordeaux Aquitaine Santé, Polyclinique Jean Villar, Bruges, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Chiron
authors.affiliation: Clinique Francheville, Perigueux, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Floret
authors.affiliation: Polyclinique de Navarre, Pau, France.
authors.forename: Steven
authors.initials: S
authors.lastname: Cens
authors.affiliation: Centre Fivete Côte Basque, Bayonne, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Bourrinet
authors.affiliation: Centre d'AMP, Hôpital Mère et Enfant, Limoges, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Paulhac
authors.affiliation: Biologie de la Reproduction-CECOS Groupe Hospitalier Pellegrin-Maternité, Bordeaux, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Jimenez
authors.affiliation: Médecine de la Reproduction, CHU Toulouse, Toulouse, France; Groupe de Recherche en Fertilité Humaine EA 3694, Université Paul Sabatier, Toulouse, France. Electronic address: parinaud.j@chu-toulouse.fr.
authors.forename: Jean
authors.initials: J
authors.lastname: Parinaud
authors.affiliation: Médecine de la Reproduction, CHU Toulouse, Toulouse, France; Groupe de Recherche en Fertilité Humaine EA 3694, Université Paul Sabatier, Toulouse, France.
authors.forename: Roger
authors.initials: R
authors.lastname: Leandri
mesh_terms: D000328:Adult; D005260:Female; D005602:France / Q000453:epidemiology; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006727:Hormone Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods* / Q000592:standards* / Q000639:trends; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends; D011446:Prospective Studies; D027724:Reproductive Techniques, Assisted / Q000592:standards* / Q000639:trends; D055815:Young Adult
chemical_list: D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone
keywords: Delivery; GnRH antagonist; IUI; ovarian stimulation