title: Investigation on the ability of first trimester glycodelin and angiopoietin-2 to predict small-for-gestational age pregnancies at delivery.
abstract: BACKGROUND
  The aim was to investigate whether first trimester glycodelin and angiopoietin-2 can predict small-for-gestational age (SGA) at delivery, individually or in combination.
  
  
  METHODS
  In this case-control study we measured glycodelin and angiopoietin-2 on serum from 170 singleton pregnant women delivering SGA neonates and 985 singleton pregnant women delivering normal-weighted neonates. All values were converted to multiples of the medians (MoM).
  
  
  RESULTS
  Pregnant women delivering SGA neonates had lower first trimester glycodelin and angiopoietin-2 MoM values [median (interquartile range)] compared with pregnant women delivering normal-weighted neonates for glycodelin: 0.86 (0.58-1.24) vs. 1.03 (0.74-1.45), p<0.001, and for angiopoietin-2: 0.89 (0.69-1.19) vs. 1.01 (0.78-1.31), p<0.001. The prediction performances of the biomarkers showed that the areas under the curve (AUC) were 0.59 (glycodelin), 0.58 (angiopoietin-2), and 0.60 (glycodelin and angiopoietin-2).
  
  
  CONCLUSIONS
  We demonstrated that first trimester glycodelin and angiopoietin-2 were associated with SGA, but they were, individually and in combination, poor predictors of SGA at delivery. The AUCs were low which indicate low detection rates and high false positive rates.
authors.forename: Young Bae
authors.identifier: http://orcid.org/0000-0002-8428-560X
authors.initials: YB
authors.lastname: Hansen
authors.forename: Vibeke
authors.initials: V
authors.lastname: Myrhøj
authors.forename: Finn Stener
authors.initials: FS
authors.lastname: Jørgensen
authors.forename: Steen
authors.initials: S
authors.lastname: Sørensen
mesh_terms: D000328:Adult; D042702:Angiopoietin-2 / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D036861:Delivery, Obstetric; D005260:Female; D005865:Gestational Age; D000071816:Glycodelin / Q000097:blood*; D006801:Humans; D007236:Infant, Small for Gestational Age / Q000097:blood*; D016014:Linear Models; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First / Q000097:blood*
chemical_list: D042702:Angiopoietin-2; D015415:Biomarkers; D000071816:Glycodelin; C045246:PAEP protein, human