title: Ground Control to Major Tom: The Cell Body Signals Axon Degeneration.
abstract: Axon degeneration in response to trophic deprivation was thought to be locally restricted to the axon. However, increasing evidence points to a requirement for the cell body in the degenerative program. Now, Simon et al. identify the pro-apoptotic protein Puma as a key factor in this cell body-derived signal.
authors.affiliation: Division of Biological Sciences, Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: wknowlton@ucsd.edu.
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Knowlton
authors.affiliation: Division of Biological Sciences, Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA; Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: yijin@ucsd.edu.
authors.forename: Yishi
authors.initials: Y
authors.lastname: Jin
mesh_terms: D000818:Animals; D001369:Axons / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D015398:Signal Transduction