title: Prealbumin/CRP Based Prognostic Score, a New Tool for Predicting Metastasis in Patients with Inoperable Gastric Cancer.
abstract: Background. There is a considerable dissimilarity in the survival duration of the patients with gastric cancer. We aimed to assess the systemic inflammatory response (SIR) and nutritional status of these patients before the commencement of chemotherapy to find the appropriate prognostic factors and define a new score for predicting metastasis. Methods. SIR was assessed using Glasgow Prognostic Score (GPS). Then a score was defined as prealbumin/CRP based prognostic score (PCPS) to be compared with GPS for predicting metastasis and nutritional status. Results. 71 patients with gastric cancer were recruited in the study. 87% of patients had malnutrition. There was a statistical difference between those with metastatic (n = 43) and those with nonmetastatic (n = 28) gastric cancer according to levels of prealbumin and CRP; however they were not different regarding patient generated subjective global assessment (PG-SGA) and GPS. The best cut-off value for prealbumin was determined at 0.20 mg/dL and PCPS could predict metastasis with 76.5% sensitivity, 63.6% specificity, and 71.4% accuracy. Metastatic and nonmetastatic gastric cancer patients were different in terms of PCPS (P = 0.005). Conclusion. PCPS has been suggested for predicting metastasis in patients with gastric cancer. Future studies with larger sample size have been warranted.
authors.affiliation: Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Esfahani
authors.affiliation: School of Medicine, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Makhdami
authors.affiliation: Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran.
authors.forename: Elnaz
authors.initials: E
authors.lastname: Faramarzi
authors.affiliation: Tabriz Health Services Management Research Center and Department of Statistics and Epidemiology, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Asghari Jafarabadi
authors.affiliation: Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Ostadrahimi
authors.affiliation: Common Diseases Risk Factors Management Institute, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran.
authors.forename: Mousa
authors.initials: M
authors.lastname: Ghayour Nahand
authors.affiliation: Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Ghoreishi