title: Immune Tolerance for Autoimmune Disease and Cell Transplantation.
abstract: The undesired destruction of healthy cells, either endogenous or transplanted, by the immune system results in the loss of tissue function or limits strategies to restore tissue function. Current therapies typically involve nonspecific immunosuppression that may prevent the appropriate response to an antigen, thereby decreasing humoral immunity and increasing the risks of patient susceptibility to opportunistic infections, viral reactivation, and neoplasia. The induction of antigen-specific immunological tolerance to block undesired immune responses to self- or allogeneic antigens, while maintaining the integrity of the remaining immune system, has the potential to transform the current treatment of autoimmune disease and serve as a key enabling technology for therapies based on cell transplantation.
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension.|Comprehensive Cancer Center, and.
authors.forename: Xunrong
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Microbiology-Immunology and Interdepartmental Immunobiology Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; email: xunrongluo@northwestern.edu , s-d-miller@northwestern.edu.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Miller
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109; email: ldshea@umich.edu.
authors.forename: Lonnie D
authors.initials: LD
authors.lastname: Shea
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D017690:Cell Transplantation / Q000379:methods*; D019317:Evidence-Based Medicine; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007165:Immunosuppression Therapy / Q000379:methods*; D018448:Models, Immunological; D016896:Treatment Outcome
keywords: cell therapies; immunomodulation; inverse vaccines; nanotechnology; tolerance