title: A Multidimensional Risk Score to Predict All-Cause Hospitalization in Community-Dwelling Older Individuals With Obstructive Lung Disease.
abstract: Both respiratory and nonrespiratory hospitalizations are common and costly events in older individuals with obstructive lung disease. Prevention of any hospitalization in these individuals is essential. We aimed to construct a prediction model for all-cause hospitalization risk in community-dwelling older individuals with obstructive lung disease.
  
  
  
  We studied 268 community-dwelling individuals with obstructive lung disease (defined as FEV1/FVC<LLN) who participated in the observational Health, Aging, and Body Composition Study and constructed a prediction model for 9-year all-cause hospitalization risk using a weighted linear combination based on beta coefficients.
  
  
  
  There were 225 individuals with 1 or more hospitalizations and 43 individuals free from hospitalization during the follow-up. Heart and vascular disease (H), objectively measured lower extremity dysfunction (O), systemic inflammation (S), dyspnea (P), impaired renal function (I), and tobacco exposure (T) were independent predictors for all-cause hospitalization (ALL). These factors were combined into the HOSPITALL score (0-23 points), with an area under the curve in ROC analysis of 0.70 (P < .001). The hazard ratio for all-cause hospitalization per 1-point increase in the HOSPITALL score was 1.15 (95% confidence interval, 1.11-1.19, P = .001). Increasing HOSPITALL score was further associated with shorter time to first admission, increased admission rate, and more respiratory admissions.
  
  
  
  The HOSPITALL score is a multidimensional score to predict all-cause hospitalization risk in community-dwelling older individuals with obstructive lung disease that may aid in patient counseling and prevention to reduce burden and health care costs.
authors.affiliation: NUTRIM School for Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.
authors.forename: Rosanne J H C G
authors.initials: RJ
authors.lastname: Beijers
authors.affiliation: NUTRIM School for Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands. Electronic address: b.vdborst@maastrichtuniversity.nl.
authors.forename: Bram
authors.initials: B
authors.lastname: van den Borst
authors.affiliation: Department of Epidemiology and Center for Aging and Population Research, University of Pittsburgh, Pittsburgh, PA.
authors.forename: Anne B
authors.initials: AB
authors.lastname: Newman
authors.affiliation: Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA.
authors.forename: Sachin
authors.initials: S
authors.lastname: Yende
authors.affiliation: Department of Internal Medicine, Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kritchevsky
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, NY; Department of Healthcare Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Cassano
authors.affiliation: Department of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, CA.
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Bauer
authors.affiliation: Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD.
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
authors.affiliation: NUTRIM School for Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.
authors.forename: Annemie M W J
authors.initials: AM
authors.lastname: Schols
mesh_terms: D000368:Aged; D005260:Female; D006707:Homes for the Aged; D006760:Hospitalization; D006801:Humans; D008173:Lung Diseases, Obstructive; D008297:Male; D016016:Proportional Hazards Models; D018570:Risk Assessment / Q000379:methods
keywords: COPD; Cox proportional hazards modeling; older age persons; pulmonary disease