title: The effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic rats.
abstract: BACKGROUND
  Sugammadex is primarily excreted via renal route. We investigated effects of low and high doses of sugammadex (16 mg/kg versus 96 mg/kg) on renal tissue samples of streptozotocin-induced diabetic rats.
  
  
  METHODS
  Twenty-four Wistar albino rats were divided into 4 groups. Group C (control - 0.9 % NaCl), Group DC (diabetes control; 55 mg/kg streptozotocin, IP, only), Group DR-16S (diabetes-rocuronium - 16 mg sugammadex, IV.) and Group DR-96S (diabetes- rocuronium - 96 mg sugammadex, IV). Renal tissue histopathological evaluation and antioxidant status (measurements of MDA levels and NO activities) were studied.
  
  
  RESULTS
  Significantly higher levels of all inflammation parameters (inflammation, degeneration/necrosis, tubular dilatation, tubular cell degeneration, dilatation in Bowman's space, tubular hyaline casts, and lymphocyte infiltration) were found in the 96 mg/kg sugammadex group. Higher MDA tissue levels and lower NO activity were found in the 96 mg/kg sugammadex group.
  
  
  CONCLUSIONS
  We can conclude that high-dose (96 mg/kg) sugammadex administration resulted in significant renal tissue damage in diabetic rats. As a consequence, low doses of sugammadex have to be preferred in diabetic patients (Tab. 2, Fig. 4, Ref. 26).
authors.forename: G
authors.initials: G
authors.lastname: Kip
authors.forename: H C
authors.initials: HC
authors.lastname: Turgut
authors.forename: M
authors.initials: M
authors.lastname: Alkan
authors.forename: M E
authors.initials: ME
authors.lastname: Aydin
authors.forename: M E
authors.initials: ME
authors.lastname: Erbatur
authors.forename: H A
authors.initials: HA
authors.lastname: Kiraz
authors.forename: S
authors.initials: S
authors.lastname: Kartal
authors.forename: H
authors.initials: H
authors.lastname: Boyunaga
authors.forename: F M
authors.initials: FM
authors.lastname: Comu
authors.forename: O
authors.initials: O
authors.lastname: Erdem
authors.forename: M
authors.initials: M
authors.lastname: Arslan
authors.forename: Y
authors.initials: Y
authors.lastname: Unal
keywords: diabetes; renal damage.; streptozotocin; sugammadex