title: The role of the endoplasmic reticulum stress in stemness, pluripotency and development.
abstract: The molecular machinery of endoplasmic reticulum (ER) integrates various intracellular and extracellular cues to maintain homeostasis in diverse physiological or pathological scenarios. ER stress and the unfolded protein response (UPR) have been found to mediate molecular and biochemical mechanisms that affect cell proliferation, differentiation, and apoptosis. Although a number of reviews on the ER stress response have been published, comprehensive reviews that broadly summarize ER physiology in the context of pluripotency, embryonic development, and tissue homeostasis are lacking. This review complements the current ER literature and provides a summary of the important findings on the role of the ER stress and UPR in embryonic development and pluripotent stem cells.
authors.affiliation: Masaryk University, Faculty of Medicine, Department of Histology and Embryology, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.
authors.forename: Kateřina
authors.initials: K
authors.lastname: Kratochvílová
authors.affiliation: Masaryk University, Faculty of Medicine, Department of Histology and Embryology, Brno, Czech Republic.
authors.forename: Lukáš
authors.initials: L
authors.lastname: Moráň
authors.affiliation: International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
authors.forename: Stanislava
authors.initials: S
authors.lastname: Paďourová
authors.affiliation: International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
authors.forename: Stanislav
authors.initials: S
authors.lastname: Stejskal
authors.affiliation: International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
authors.forename: Lenka
authors.initials: L
authors.lastname: Tesařová
authors.affiliation: Masaryk University, Faculty of Medicine, Department of Histology and Embryology, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Šimara
authors.affiliation: Masaryk University, Faculty of Medicine, Department of Histology and Embryology, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.
authors.forename: Aleš
authors.initials: A
authors.lastname: Hampl
authors.affiliation: International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
authors.forename: Irena
authors.initials: I
authors.lastname: Koutná
authors.affiliation: Masaryk University, Faculty of Medicine, Department of Histology and Embryology, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic. Electronic address: pvanhara@med.muni.cz.
authors.forename: Petr
authors.initials: P
authors.lastname: Vaňhara
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D047108:Embryonic Development; D059865:Endoplasmic Reticulum Stress; D006706:Homeostasis; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism
keywords: Development; Embryonic stem cells; Endoplasmic reticulum stress; Pluripotency; Unfolded protein response