title: Need for testing glucose tolerance in the early weeks of pregnancy.
abstract: OBJECTIVE
  This observational study aims to determine the frequency of occurrence of glucose intolerance in the early weeks of pregnancy.
  
  
  METHODS
  New World Health Organization 2013 guidelines recommends "A Single Step Procedure" (SSP) as an option for diagnosing gestational diabetes mellitus (GDM). Pregnant women attending 131 prenatal clinics across India for the first time underwent SSP consisting of administration of 75 goral glucose irrespective of the last meal timing and to diagnose GDM with 2 h plasma glucose (PG) value ≥7.8 mmol/L (7.8 mmol/L).
  
  
  RESULTS
  In a cohort of n = 11,785, the number of pregnant women who underwent the test in first, second, and third trimesters were 4300, 4632, and 2853, respectively. Documented blood glucose values were available for 9282 pregnant women and in them, diagnosis of GDM was made in 740 (8%). Among them, 233 (31.5%), 320 (43.2%), and 187 (25.3%) were in the first, second and third trimesters, respectively. Positive family history of diabetes (43%) and history of fetal loss in previous pregnancy (27%) was more common in women diagnosed with GDM in the first trimester compared to GDM diagnosed in the second or third trimester.
  
  
  CONCLUSIONS
  Manifestation of GDM in the early weeks of gestation is quite common.
authors.affiliation: Diabetes in Pregnancy Study Group India, Bengaluru, Karnataka, India; International Association of Diabetes and Pregnancy Study Group, Bengaluru, Karnataka, India; Dr. Balaji Diabetes Care Centre and Dr. V. Seshiah Diabetes Research Institute, Bengaluru, Karnataka, India; Expert Review Committee, Bengaluru, Karnataka, India; Expert Group Committee on GDM, Bengaluru, Karnataka, India; Ministry of Health Government of India and Indian Council of Medical Research, Bengaluru, Karnataka, India.
authors.forename: Seshiah
authors.initials: S
authors.lastname: Veeraswamy
authors.affiliation: Federation of Obstetrics and Gynecology Society India, Bengaluru, Karnataka, India; Divakar's Speciality Hospital, Bengaluru, Karnataka, India.
authors.forename: Hema
authors.initials: H
authors.lastname: Divakar
authors.affiliation: Gupte Hospitals, Pune, Maharashtra.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gupte
authors.affiliation: Department of Epidemiology, The Tamil Nadu Dr. MGR Medical University, Chennai, Tamil Nadu, India.
authors.forename: Manjula
authors.initials: M
authors.lastname: Datta
authors.affiliation: Diabetes in Pregnancy Study Group India, Bengaluru, Karnataka, India; Chairman, World Diabetes Foundation.
authors.forename: Anil
authors.initials: A
authors.lastname: Kapur
authors.affiliation: Diabetes in Pregnancy Study Group India, Bengaluru, Karnataka, India; International Association of Diabetes and Pregnancy Study Group, Bengaluru, Karnataka, India; Dr. Balaji Diabetes Care Centre and Dr. V. Seshiah Diabetes Research Institute, Bengaluru, Karnataka, India; Expert Group Committee on GDM, Bengaluru, Karnataka, India; Ministry of Health Government of India and Indian Council of Medical Research, Bengaluru, Karnataka, India.
authors.forename: Balaji
authors.initials: B
authors.lastname: Vijayam
keywords: Gestational diabetes mellitus; plasma glucose; single step procedure