title: Oral Cancer Chernoprevention: Current Status and Future Direction.
abstract: The aim of this study is to review the current status of cancer chemoprevention and its effectiveness in treatment of oral premalignant lesions and prevention of their progression to oral cancer. The challenges encountered in the different oral cancer chemoprevention clinical trials, including lack of surrogate endpoints, reversal of histologic premalignant changes as study endpoints, tobacco use, human papillomavirus, delivery system, adverse effects and risk of bias in clinical studies, are presented.
authors.forename: Diana V
authors.initials: DV
authors.lastname: Messadi
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Sato
mesh_terms: D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D063646:Carcinogenesis / Q000187:drug effects; D002338:Carotenoids / Q000627:therapeutic use; D002392:Catechin / Q000031:analogs & derivatives / Q000627:therapeutic use; D018890:Chemoprevention; D006801:Humans; D009062:Mouth Neoplasms / Q000517:prevention & control*; D028321:Plant Preparations / Q000627:therapeutic use; D011230:Precancerous Conditions / Q000517:prevention & control*; D014358:Trypsin Inhibitor, Bowman-Birk Soybean / Q000627:therapeutic use; D014361:Trypsin Inhibitors / Q000627:therapeutic use
chemical_list: D016588:Anticarcinogenic Agents; D028321:Plant Preparations; D014358:Trypsin Inhibitor, Bowman-Birk Soybean; D014361:Trypsin Inhibitors; D002338:Carotenoids; D002392:Catechin; C045651:epigallocatechin gallate