title: Nursing Roles in Cardiac Safety: Romidepsin in Patients With T-Cell Lymphoma.
abstract: OBJECTIVE
  To provide information to help nurses mitigate cardiac risks among patients receiving romidepsin (Istodax®), a histone deacetylase (HDAC) inhibitor approved by the U.S. Food and Drug Administration for the treatment of relapsed/refractory cutaneous and peripheral T-cell lymphoma.  .
  
  
  METHODS
  Clinical studies of romidepsin represented the primary data sources. Supporting references included class information on HDAC inhibitors, as well as data regarding the impact of electrolyte imbalances and antiemetic treatment on electrocardiogram (ECG) data. .
  
  
  RESULTS
  Cardiac concerns during treatment with romidepsin are multifactorial. Electrolyte deficiencies, which are associated with ECG abnormalities and dysrhythmias, are common among patients with T-cell lymphoma. In addition, clinically insignificant changes in the corrected QT interval reported with romidepsin are primarily attributable to concomitant use of prophylactic antiemetics and likely exaggerated by transient increases in heart rate.  .
  
  
  CONCLUSIONS
  Data support the cardiac safety of romidepsin while cautioning about the need for nurses' vigilance regarding consistent electrolyte supplementation, appropriate antiemetic selection, and heart rate monitoring.  .
  
  
  CONCLUSIONS
  By recognizing drug-related and non-drug-related influences on cardiac safety during treatment with romidepsin, as well as other anticancer agents, nurses can identify risks, report them, and recommend appropriate interventions, which, ultimately, facilitates improved patient outcomes.
authors.affiliation: Sarah Cannon Research Institute at Tennessee Oncology.
authors.forename: Jan
authors.initials: J
authors.lastname: Hronek
authors.affiliation: Tennessee Oncology.
authors.forename: Maureen
authors.initials: M
authors.lastname: Reed
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D047630:Depsipeptides / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006323:Heart Arrest / Q000209:etiology* / Q000451:nursing* / Q000517:prevention & control; D056572:Histone Deacetylase Inhibitors / Q000627:therapeutic use; D006801:Humans; D016399:Lymphoma, T-Cell / Q000188:drug therapy* / Q000451:nursing*; D008297:Male; D024802:Nurse's Role; D009859:Oncology Nursing / Q000379:methods; D014481:United States
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D047630:Depsipeptides; D056572:Histone Deacetylase Inhibitors; C087123:romidepsin
keywords: HDAC inhibitors; antiemetics; electrocardiography; electrolytes; romidepsin