title: An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin.
abstract: Scutellarein (2), which is an important in vivo metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This strategy relies on acetylation, aldolization, cyclization and hydrolysis reactions, respectively.
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. dongzexi1215@163.com.
authors.forename: Ze-Xi
authors.initials: ZX
authors.lastname: Dong
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. linianguang@njutcm.edu.cn.
authors.forename: Nian-Guang
authors.initials: NG
authors.lastname: Li
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. zpx20130901@126.com.
authors.forename: Peng-Xuan
authors.initials: PX
authors.lastname: Zhang
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. guting1992@163.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Gu
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. 15150513147@163.com.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Wu
authors.affiliation: Department of Organic Chemistry, China Pharmaceutical University, Nanjing 211198, Jiangsu, China. sszh163@163.com.
authors.forename: Zhi-Hao
authors.initials: ZH
authors.lastname: Shi
mesh_terms: D000107:Acetylation; D000818:Animals; D047310:Apigenin / Q000138:chemical synthesis*; D002317:Cardiovascular Agents / Q000138:chemical synthesis*; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D005965:Glucuronates / Q000138:chemical synthesis*; D006801:Humans; D006868:Hydrolysis; D018696:Neuroprotective Agents / Q000138:chemical synthesis*; D010636:Phenols / Q000737:chemistry
chemical_list: D002317:Cardiovascular Agents; D005965:Glucuronates; D018696:Neuroprotective Agents; D010636:Phenols; C484876:scutellarin; D047310:Apigenin; C458179:scutellarein
keywords: efficient; metabolite; scutellarein; scutellarin; synthesis