title: Implications of the Interaction Between miRNAs and Autophagy in Osteoporosis.
abstract: Imbalances between bone formation and resorption are the primary cause of osteoporosis. However, currently, a detailed molecular mechanism of osteoporosis is not available. Autophagy is the conserved process characterized by degrading and recycling aggregated proteins, intracellular pathogens, and damaged organelles. MicroRNAs (miRNAs) are novel regulatory factors that play important roles in numerous cellular processes, including autophagy, through the posttranscriptional regulation of gene expression. Conversely, autophagy plays a role in the regulation of miRNA homeostasis. Recent advances have revealed that both autophagy and miRNAs are involved in the maintenance of bone homoeostasis, whereas the role of the interaction of miRNAs with autophagy in osteoporosis remains unclear. In this paper, we review previous reports on autophagy, miRNAs, and their interaction in osteoporosis.
authors.affiliation: Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
authors.forename: Gengyang
authors.initials: G
authors.lastname: Shen
authors.affiliation: Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ren
authors.affiliation: Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Qiu
authors.affiliation: Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
authors.forename: De
authors.initials: D
authors.lastname: Liang
authors.affiliation: The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xie
authors.affiliation: Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
authors.forename: Zhida
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
authors.forename: Zhensong
authors.initials: Z
authors.lastname: Yao
authors.affiliation: Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. spinedrjxb@sina.com.|Laboratory Affiliated to National Key Discipline of Orthopaedic and Traumatology of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. spinedrjxb@sina.com.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics*; D005786:Gene Expression Regulation / Q000502:physiology*; D006706:Homeostasis / Q000235:genetics / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D010012:Osteogenesis / Q000502:physiology*; D010024:Osteoporosis / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
keywords: Autophagy; Mechanism; Osteoporosis; miRNAs