title: Electrical characteristic of the titanium mesh electrode for transcutaneous intrabody communication to monitor implantable artificial organs.
abstract: We have developed a tissue-inducing electrode using titanium mesh to obtain mechanically and electrically stable contact with the tissue for a new transcutaneous communication system using the human body as a conductive medium. In this study, we investigated the electrical properties of the titanium mesh electrode by measuring electrode-tissue interface resistance in vivo. The titanium mesh electrode (Hi-Lex Co., Zellez, Hyogo, Japan) consisted of titanium fibers (diameter of 50 μm), and it has an average pore size of 200 μm and 87 % porosity. The titanium mesh electrode has a diameter of 5 mm and thickness of 1.5 mm. Three titanium mesh electrodes were implanted separately into the dorsal region of the rat. We measured the electrode-electrode impedance using an LCR meter for 12 weeks, and we calculated the tissue resistivity and electrode-tissue interface resistance. The electrode-tissue interface resistance of the titanium mesh electrode decreased slightly until the third POD and then continuously increased to 75 Ω. The electrode-tissue interface resistance of the titanium mesh electrode is stable and it has lower electrode-tissue interface resistance than that of a titanium disk electrode. The extracted titanium mesh electrode after 12 weeks implantation was fixed in 10 % buffered formalin solution and stained with hematoxylin-eosin. Light microscopic observation showed that the titanium mesh electrode was filled with connective tissue, inflammatory cells and fibroblasts with some capillaries in the pores of the titanium mesh. The results indicate that the titanium mesh electrode is a promising electrode for the new transcutaneous communication system.
authors.affiliation: Graduate School of Science and Engineering, Tokai University, Minami-sawa 5-1-1-1, Minami-ku, Sapporo, 005-8601, Japan. okamoto29@tsc.u-tokai.ac.jp.
authors.forename: Eiji
authors.initials: E
authors.lastname: Okamoto
authors.affiliation: Graduate School of Science and Engineering, Tokai University, Minami-sawa 5-1-1-1, Minami-ku, Sapporo, 005-8601, Japan.
authors.forename: Sakiko
authors.initials: S
authors.lastname: Kikuchi
authors.affiliation: Graduate School of Science and Engineering, Tokai University, Minami-sawa 5-1-1-1, Minami-ku, Sapporo, 005-8601, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mitamura
mesh_terms: D000818:Animals; D001187:Artificial Organs; D001823:Body Composition / Q000502:physiology*; D017097:Electric Impedance; D004567:Electrodes, Implanted; D007564:Japan; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D016062:Porosity; D051381:Rats; D014025:Titanium
chemical_list: D014025:Titanium
keywords: Artificial heart; Electrode; Scaffold; Titanium mesh; Transcutaneous communication