title: A model qualification method for mechanistic physiological QSP models to support model-informed drug development.
abstract: Mechanistic physiological modeling is a scientific method that combines available data with scientific knowledge and engineering approaches to facilitate better understanding of biological systems, improve decision-making, reduce risk, and increase efficiency in drug discovery and development. It is a type of quantitative systems pharmacology (QSP) approach that places drug-specific properties in the context of disease biology. This tutorial provides a broadly applicable model qualification method (MQM) to ensure that mechanistic physiological models are fit for their intended purposes.
authors.affiliation: Rosa & Co, LLC San Francisco California USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Friedrich
mesh_terms: D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D049490:Systems Biology / Q000379:methods