title: Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications.
abstract: Endogenous damage-associated molecular patterns (DAMPs) are released during tissue damage and have increasingly recognized roles in the etiology of many human diseases. The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD), are immune-mediated conditions where high levels of DAMPs are observed. DAMPs such as calprotectin (S100A8/9) have an established clinical role as a biomarker in IBD. In this review, we use IBD as an archetypal common chronic inflammatory disease to focus on the conceptual and evidential importance of DAMPs in pathogenesis and why DAMPs represent an entirely new class of targets for clinical translation.
authors.affiliation: MRC Centre for Inflammation Research, Queens Medical Research Institute, Edinburgh, UK.|Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.
authors.forename: R K
authors.initials: RK
authors.lastname: Boyapati
authors.affiliation: MRC Centre for Inflammation Research, Queens Medical Research Institute, Edinburgh, UK.
authors.forename: A G
authors.initials: AG
authors.lastname: Rossi
authors.affiliation: Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.
authors.forename: J
authors.initials: J
authors.lastname: Satsangi
authors.affiliation: MRC Centre for Inflammation Research, Queens Medical Research Institute, Edinburgh, UK.|Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.
authors.forename: G-T
authors.initials: GT
authors.lastname: Ho
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000628:therapy; D007413:Intestinal Mucosa / Q000276:immunology*; D039841:Leukocyte L1 Antigen Complex / Q000378:metabolism; D058990:Molecular Targeted Therapy; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D057170:Translational Research, Biomedical
chemical_list: D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex; D051192:Receptors, Pattern Recognition