title: Lethal acute liver failure in a patient treated with sunitinib.
abstract: Sunitinib is a tyrosine kinase inhibitor that is used as an anticancer drug in renal cell carcinoma (RCC), pancreatic neuroendocrine tumours (PNETs) and gastrointestinal stromal tumour. Elevated liver enzymes are frequently observed during treatment but acute liver failure is uncommon. We describe a case of fulminant acute liver failure and acute kidney injury during treatment with sunitinib for metastatic RCC.
authors.affiliation: Department of Internal Medicine, Ikazia Hospital, Rotterdam, The Netherlands.
authors.forename: S S
authors.initials: SS
authors.lastname: Guillen
authors.affiliation: Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Meijer
authors.affiliation: Department of Internal Medicine, Ikazia Hospital, Rotterdam, The Netherlands.
authors.forename: F E
authors.initials: FE
authors.lastname: de Jongh
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000188:drug therapy / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D007211:Indoles / Q000009:adverse effects* / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology; D017114:Liver Failure, Acute / Q000139:chemically induced*; D008297:Male; D009362:Neoplasm Metastasis; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D011758:Pyrroles / Q000009:adverse effects* / Q000627:therapeutic use; D000077210:Sunitinib
chemical_list: D007211:Indoles; D047428:Protein Kinase Inhibitors; D011758:Pyrroles; D000077210:Sunitinib