title: Associação entre lipid accumulation product (LAP) e hirsutismo na síndrome do ovário policístico.
abstract: OBJECTIVE
  Polycystic ovary syndrome (PCOS) is the most common endocrine metabolic disorder in women between menarche and menopause. Clinical hyperandrogenism is the most important diagnostic criterion of the syndrome, which manifests as hirsutism in 70% of cases. Hirsute carriers of PCOS have high cardiovascular risk. Lipid accumulation product (LAP) is an index for the evaluation of lipid accumulation in adults and the prediction of cardiovascular risk. The aim of this study was to evaluate the association between LAP and hirsutism in women with PCOS.
  
  
  METHODS
  This was a cross-sectional observational study of a secondary database, which included 263 patients who had visited the Hyperandrogenism Outpatient Clinic from November 2009 to July 2014. The exclusion criteria were patients without Ferriman-Gallwey index (FGI) and/or LAP data. We used the Rotterdam criteria for the diagnosis of PCOS. All patients underwent medical assessment followed by measurement and recording of anthropometric data and the laboratory tests for measurement of the following: thyroid-stimulating hormone, follicle-stimulating hormone, prolactin, total testosterone, sex hormone binding globulin, 17-α-hydroxyprogesterone (follicular phase), glycohemoglobin A1c, and basal insulin. In addition, the subjects underwent lipid profiling and oral glucose tolerance tests. Other laboratory measurements were determined according to clinical criteria. LAP and the homeostatic model assessment index (HOMA-IR) were calculated using the data obtained. We divided patients into two groups: the PCOS group with normal LAP (< 34.5) and the PCOS group with altered LAP (> 34.5) to compare the occurrence of hirsutism. For statistical analysis, we used SPSS Statistics for Windows® and Microsoft Excel programs, with descriptive (frequencies, percentages, means, and standard deviations) and comparative analyses (Student's t-test and Chi-square test). We considered relations significant when the p-value was ≤ 0.05.
  
  
  RESULTS
  LAP was high in most patients (n = 177; 67.3%) and the FGI indicated that 58.5% of the patients (n = 154) had hirsutism. The analysis by LAP quartiles showed a positive correlation (p = 0.04) among patients with a high FGI and an upper quartile LAP (> 79.5) when compared with those with LAP < 29.0 (lower quartile).
  
  
  CONCLUSIONS
  This study demonstrated an association between high LAP and hirsutism. The FGI could represent a simple and low-cost tool to infer an increased cardiovascular risk in women with PCOS.
authors.affiliation: Faculdade de Saúde e Ecologia Humana - FASEH, Vespasiano, Brazil; Laboratory of Human Reproduction, Hospital das Clínicas, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, MG, Brazil.
authors.forename: Flávia Ribeiro
authors.initials: FR
authors.lastname: de Oliveira
authors.affiliation: Undergraduate Medical Course, FASEH, Vespasiano, MG, Brazil.
authors.forename: Mariana Bicalho
authors.initials: MB
authors.lastname: Rezende
authors.affiliation: Undergraduate Medical Course, FASEH, Vespasiano, MG, Brazil.
authors.forename: Nícolas Figueiredo
authors.initials: NF
authors.lastname: Faria
authors.affiliation: Undergraduate Medical Course, FASEH, Vespasiano, MG, Brazil.
authors.forename: Tomás Ribeiro Gonçalves
authors.initials: TR
authors.lastname: Dias
authors.affiliation: Undergraduate Medical Course, FASEH, Vespasiano, MG, Brazil.
authors.forename: Walter Carlos Santos
authors.initials: WC
authors.lastname: de Oliveira
authors.affiliation: Department of Gynecology and Obstetrics, School of Medicine; Laboratory of Human Reproduction and Hyperandrogenism Outpatient Clinic, Hospital das Clínicas, UFMG, Belo Horizonte, MG, Brazil.
authors.forename: Ana Luiza Lunardi
authors.initials: AL
authors.lastname: Rocha
authors.affiliation: Department of Clinical Medicine, School of Medicine; Hyperandrogenism Outpatient Clinic, Hospital das Clínicas, UFMG, Belo Horizonte, MG, Brazil.
authors.forename: Ana Lúcia
authors.initials: AL
authors.lastname: Cândido
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases; D003430:Cross-Sectional Studies; D005260:Female; D006628:Hirsutism; D006801:Humans; D017588:Hyperandrogenism; D064237:Lipid Accumulation Product; D011085:Polycystic Ovary Syndrome; D012307:Risk Factors