title: Patients that have Undergone Hemodialysis Exhibit Lower Amyloid Deposition in the Brain: Evidence Supporting a Therapeutic Strategy for Alzheimer's Disease by Removal of Blood Amyloid.
abstract: As a proof of concept that removal of blood amyloid-β (Aβ) can reduce Aβ deposition in the brains of patients with Alzheimer's disease, cortices of patients who had undergone hemodialysis (HD), which removes Aβ from the blood, were histochemically analyzed; postmortem brain sections were stained with anti-Aβ antibodies. Brains from patients who had undergone HD had significantly fewer senile plaques than those of patient who had not undergone HD. This significant difference was also confirmed by silver staining. Our findings suggest that removal of blood Aβ by hemodialysis results in lower accumulation of Aβ in the brain.
authors.affiliation: Faculty of Clinical Engineering, School of Health Sciences, Fujita Health University, Toyoake, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Sakai
authors.affiliation: Department of Anatomy I, School of Medicine, Fujita Health University, Toyoake, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Senda
authors.affiliation: Department of Anatomy I, School of Medicine, Fujita Health University, Toyoake, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Hata
authors.affiliation: Department of Diagnostic Pathology, School of Medicine, Fujita Health University, Toyoake, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kuroda
authors.affiliation: Department of Nephrology, School of Medicine, Fujita Health University, Toyoake, Japan.
authors.forename: Midori
authors.initials: M
authors.lastname: Hasegawa
authors.affiliation: Department of Nephrology, School of Medicine, Fujita Health University, Toyoake, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Kato
authors.affiliation: Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Toyoake, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Abe
authors.affiliation: Faculty of Clinical Engineering, School of Health Sciences, Fujita Health University, Toyoake, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kawaguchi
authors.affiliation: Faculty of Clinical Engineering, School of Health Sciences, Fujita Health University, Toyoake, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nakai
authors.affiliation: Faculty of Clinical Engineering, School of Health Sciences, Fujita Health University, Toyoake, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hiki
authors.affiliation: Department of Nephrology, School of Medicine, Fujita Health University, Toyoake, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yuzawa
authors.affiliation: Faculty of Clinical Engineering, School of Health Sciences, Fujita Health University, Toyoake, Japan.
authors.forename: Nobuya
authors.initials: N
authors.lastname: Kitaguchi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001344:Autopsy; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D016022:Case-Control Studies; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology / Q000628:therapy; D058225:Plaque, Amyloid / Q000378:metabolism*; D006435:Renal Dialysis; D016622:Silver Staining; D018709:Statistics, Nonparametric
chemical_list: D016229:Amyloid beta-Peptides
keywords: Alzheimer’s disease; Aβ deposition; amyloid-β (Aβ); cerebral cortex; hemodialysis; senile plaque