title: Fabrication of biodegradable PEG-PLA nanospheres for solubility, stabilization, and delivery of curcumin.
abstract: Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)-poly (lactic acid) (PEG-PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.
authors.affiliation: a Department of Physiology & Biophysics , Albert Einstein College of Medicine , Bronx , NY , USA.
authors.forename: Hongying
authors.initials: H
authors.lastname: Liang
authors.affiliation: a Department of Physiology & Biophysics , Albert Einstein College of Medicine , Bronx , NY , USA.
authors.forename: Joel M
authors.initials: JM
authors.lastname: Friedman
authors.affiliation: a Department of Physiology & Biophysics , Albert Einstein College of Medicine , Bronx , NY , USA.
authors.forename: Parimala
authors.initials: P
authors.lastname: Nacharaju
mesh_terms: D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D054118:Nanospheres / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology
chemical_list: D011091:Polyesters; D011092:Polyethylene Glycols; C033616:poly(lactide); D003474:Curcumin; C000595209:polyethylene glycol 1000
keywords: Curcumin; drug delivery; nanospheres; poly(ethylene glycol)–poly(lactic acid)