title: Signs and Symptoms of Primary Tooth Eruption: A Meta-analysis.
abstract: BACKGROUND
  Symptoms associated with the primary tooth eruption have been extensively studied but it is still controversial.
  
  
  OBJECTIVE
  To assess the occurrence of local and systemic signs and symptoms during primary tooth eruption.
  
  
  METHODS
  Latin American and Caribbean Health Sciences, PubMed, ProQuest, Scopus, and Web of Science were searched. A partial gray literature search was taken by using Google Scholar and the reference lists of the included studies were scanned.
  
  
  METHODS
  Observational studies assessing the association of eruption of primary teeth with local and systemic signs and symptoms in children aged 0 to 36 months were included.
  
  
  METHODS
  Two authors independently collected the information from the selected articles. Information was crosschecked and confirmed for its accuracy.
  
  
  RESULTS
  A total of 1179 articles were identified, and after a 2-phase selection, 16 studies were included. Overall prevalence of signs and symptoms occurring during primary tooth eruption in children between 0 and 36 months was 70.5% (total sample = 3506). Gingival irritation (86.81%), irritability (68.19%), and drooling (55.72%) were the most frequent ones.
  
  
  CONCLUSIONS
  Different general symptoms were considered among studies. Some studies presented lack of confounding factors, no clear definition of the diagnostics methods, use of subjective measures and long intervals between examinations.
  
  
  CONCLUSIONS
  There is evidence of the occurrence of signs and symptoms during primary tooth eruption. For body temperature analyses, eruption could lead to a rise in temperature, but it was not characterized as fever.
authors.affiliation: Department of Dentistry, and.
authors.forename: Carla
authors.initials: C
authors.lastname: Massignan
authors.affiliation: Department of Dentistry, and.
authors.forename: Mariane
authors.initials: M
authors.lastname: Cardoso
authors.affiliation: Bauru School of Dentistry, Bauru, São Paulo, Brazil;
authors.forename: André Luís
authors.initials: AL
authors.lastname: Porporatti
authors.affiliation: Gulhane Military Medical Academy, Istanbul, Turkey; and.
authors.forename: Secil
authors.initials: S
authors.lastname: Aydinoz
authors.affiliation: Department of Dentistry, and Brazilian Centre for Evidence-based Research, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil; Department of Dentistry, University of Alberta, Edmonton, Canada.
authors.forename: Graziela De Luca
authors.initials: Gde L
authors.lastname: Canto
authors.affiliation: Department of Dentistry, and Brazilian Centre for Evidence-based Research, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil;
authors.forename: Luis Andre Mendonça
authors.initials: LA
authors.lastname: Mezzomo
authors.affiliation: Department of Dentistry, and michelebolan@hotmail.com.
authors.forename: Michele
authors.initials: M
authors.lastname: Bolan
mesh_terms: D001066:Appetite / Q000502:physiology*; D001831:Body Temperature / Q000502:physiology*; D002648:Child; D006801:Humans; D007508:Irritable Mood / Q000502:physiology*; D012472:Salivation; D012890:Sleep / Q000502:physiology*; D014078:Tooth Eruption / Q000502:physiology*