title: Development and evaluation of an online three-level proton vs photon decision support prototype for head and neck cancer - Comparison of dose, toxicity and cost-effectiveness.
abstract: To quantitatively assess the effectiveness of proton therapy for individual patients, we developed a prototype for an online platform for proton decision support (PRODECIS) comparing photon and proton treatments on dose metric, toxicity and cost-effectiveness levels. An evaluation was performed with 23 head and neck cancer datasets.
authors.affiliation: Department of Radiation Oncology (MAASTRO Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands.
authors.forename: Qing
authors.initials: Q
authors.lastname: Cheng
authors.affiliation: Department of Radiation Oncology (MAASTRO Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands.
authors.forename: Erik
authors.initials: E
authors.lastname: Roelofs
authors.affiliation: Department of Clinical Epidemiology and Medical Technology Assessment (KEMTA), Maastricht University Medical Center, The Netherlands.
authors.forename: Bram L T
authors.initials: BL
authors.lastname: Ramaekers
authors.affiliation: Department of Radiation Oncology (MAASTRO Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands.
authors.forename: Daniëlle
authors.initials: D
authors.lastname: Eekers
authors.affiliation: Department of Radiation Oncology (MAASTRO Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands.
authors.forename: Johan
authors.initials: J
authors.lastname: van Soest
authors.affiliation: Department of Radiation Oncology (MAASTRO Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands.
authors.forename: Tim
authors.initials: T
authors.lastname: Lustberg
authors.affiliation: Department of Radiation Oncology (MAASTRO Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands.
authors.forename: Tim
authors.initials: T
authors.lastname: Hendriks
authors.affiliation: Department of Radiation Oncology (MAASTRO Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands.
authors.forename: Frank
authors.initials: F
authors.lastname: Hoebers
authors.affiliation: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: Hans Paul
authors.initials: HP
authors.lastname: van der Laan
authors.affiliation: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: Erik W
authors.initials: EW
authors.lastname: Korevaar
authors.affiliation: Department of Radiation Oncology (MAASTRO Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands.
authors.forename: Andre
authors.initials: A
authors.lastname: Dekker
authors.affiliation: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Langendijk
authors.affiliation: Department of Radiation Oncology (MAASTRO Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands. Electronic address: philippe.lambin@maastro.nl.
authors.forename: Philippe
authors.initials: P
authors.lastname: Lambin
mesh_terms: D003362:Cost-Benefit Analysis / Q000191:economics*; D003661:Decision Support Techniques; D005069:Evaluation Studies as Topic; D006258:Head and Neck Neoplasms / Q000191:economics / Q000532:radiotherapy*; D006801:Humans; D017785:Photons / Q000627:therapeutic use*; D061766:Proton Therapy / Q000191:economics* / Q000379:methods*; D011879:Radiotherapy Dosage
keywords: Cost-effectiveness estimation; Decision support system; Mean dose extraction; Proton therapy; Quantitative comparison; Toxicity prediction