title: Immune System Modifications Induced in a Mouse Model of Chronic Exposure to (90)Sr.
abstract: Strontium 90 ((90)Sr) remains in the environment long after a major nuclear disaster occurs. As a result, populations living on contaminated land are potentially exposed to daily ingesting of low quantities of (90)Sr. The potential long-term health effects of such chronic contamination are unknown. In this study, we used a mouse model to evaluate the effects of (90)Sr ingestion on the immune system, the animals were chronically exposed to (90)Sr in drinking water at a concentration of 20 kBq/l, for a daily ingestion of 80-100 Bq/day. This resulted in a reduced number of CD19(+) B lymphocytes in the bone marrow and spleen in steady-state conditions. In contrast, the results from a vaccine experiment performed as a functional test of the immune system showed that in response to T-dependent antigens, there was a reduction in IgG specific to tetanus toxin (TT), a balanced Th1/Th2 response inducer antigen, but not to keyhole limpet hemocyanin (KLH), a strong Th2 response inducer antigen. This was accompanied by a reduction in Th1 cells in the spleen, consistent with the observed reduction in specific IgG concentration. The precise mechanisms by which (90)Sr acts on the immune system remain to be elucidated. However, our results suggest that (90)Sr ingestion may be responsible for some of the reported effects of internal contamination on the immune system in civilian populations exposed to the Chernobyl fallout.
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM/SRBE, LRTOX, Fontenay-aux-Roses, F-92262, France.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Synhaeve
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM/SRBE, LRTOX, Fontenay-aux-Roses, F-92262, France.
authors.forename: Stefania
authors.initials: S
authors.lastname: Musilli
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM/SRBE, LRTOX, Fontenay-aux-Roses, F-92262, France.
authors.forename: Johanna
authors.initials: J
authors.lastname: Stefani
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM/SRBE, LRTOX, Fontenay-aux-Roses, F-92262, France.
authors.forename: Nour
authors.initials: N
authors.lastname: Nicolas
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM/SRBE, LRTOX, Fontenay-aux-Roses, F-92262, France.
authors.forename: Olivia
authors.initials: O
authors.lastname: Delissen
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM/SRBE, LRTOX, Fontenay-aux-Roses, F-92262, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dublineau
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM/SRBE, LRTOX, Fontenay-aux-Roses, F-92262, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Bertho
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000528:radiation effects; D004195:Disease Models, Animal; D006801:Humans; D007107:Immune System / Q000473:pathology / Q000528:radiation effects*; D051379:Mice; D000069079:Radiation Exposure; D013154:Spleen / Q000473:pathology / Q000528:radiation effects; D013326:Strontium Radioisotopes / Q000009:adverse effects*
chemical_list: D013326:Strontium Radioisotopes