title: Six-month changes in ideal cardiovascular health vs. Framingham 10-year coronary heart disease risk among young adults enrolled in a weight loss intervention.
abstract: The Framingham Risk equation uses sex, age, smoking, total cholesterol, high-density lipoprotein (HDL) cholesterol and systolic blood pressure to predict 10-year risk of coronary heart disease (FR-10). The American Heart Association's Ideal Cardiovascular Health (IDEAL) score uses smoking, total cholesterol, fasting glucose, blood pressure, body mass index (BMI), diet, and physical activity to encourage a healthy cardiovascular phenotype. This study aimed to compare 6-month changes in the FR-10 vs. IDEAL score among young adults with BMI ≥25 to <40kg/m(2) enrolled in a behavioral weight loss intervention at the University of Pittsburgh (2010-12). Medians [25th, 75th percentiles] are reported. Weight decreased by 8kg [-12, -4] among 335 participants. Of 7 possible points, IDEAL score was 4 [3, 4] at baseline, improved (i.e., increased) by 1 [0, 2] over 6months, and improved in 64.2% and worsened in 6.6% of participants (p<0.001). IDEAL classification of BMI, physical activity, total cholesterol, blood pressure and glucose improved (all p<0.001), but not of smoking or diet (both p≥0.05). FR-10 was <1% at baseline for 88.1% of participants and changed in few participants (improved, i.e. decreased, in 7.5%, worsened in 1.8%, p<0.001). Among young adults with overweight or obesity enrolled in a weight loss intervention, IDEAL detected positive changes in a majority of participants while the FR-10 did not. These findings suggest that IDEAL score may be more sensitive to positive cardiovascular health changes resulting from a behavioral intervention in this population.
authors.affiliation: Department of Health and Physical Activity, University of Pittsburgh, USA. Electronic address: bbarone@pitt.edu.
authors.forename: Bethany Barone
authors.initials: BB
authors.lastname: Gibbs
authors.affiliation: Department of Epidemiology, School of Public Health, University of Pittsburgh, USA.
authors.forename: Wendy C
authors.initials: WC
authors.lastname: King
authors.affiliation: Department of Epidemiology, School of Public Health, University of Pittsburgh, USA.
authors.forename: Steven H
authors.initials: SH
authors.lastname: Belle
authors.affiliation: Department of Health and Physical Activity, University of Pittsburgh, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Jakicic
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000209:etiology / Q000517:prevention & control*; D004435:Eating; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D061217:Weight Reduction Programs / Q000706:statistics & numerical data*
chemical_list: D002784:Cholesterol
keywords: Cardiovascular health; Lifestyle; Obesity; Prevention; Risk factors; Young adults