title: Metabolic remodeling in early development and cardiomyocyte maturation.
abstract: Aberrations in metabolism contribute to a large number of diseases, such as diabetes, obesity, cancer, and cardiovascular diseases, that have a substantial impact on the mortality rates and quality of life worldwide. However, the mechanisms leading to these changes in metabolic state--and whether they are conserved between diseases--is not well understood. Changes in metabolism similar to those seen in pathological conditions are observed during normal development in a number of different cell types. This provides hope that understanding the mechanism of these metabolic switches in normal development may provide useful insight in correcting them in pathological cases. Here, we focus on the metabolic remodeling observed both in early stage embryonic stem cells and during the maturation of cardiomyocytes.
authors.affiliation: Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Ellen Kreipke
authors.affiliation: Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA; Computational Biology Program, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
authors.forename: Jason Wayne
authors.initials: JW
authors.lastname: Miklas
authors.affiliation: Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Mathieu
authors.affiliation: Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. Electronic address: hannele@uw.edu.
authors.forename: Hannele
authors.initials: H
authors.lastname: Ruohola-Baker
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000378:metabolism*
keywords: Cardiac maturation; Cardiomyocyte; Developmental transitions; Metabolism; Naïve to primed embryonic stem cell transition; Pluripotent stem cells; hESC