title: Plasma metabonomics study of first-Episode schizophrenia treated with olanzapine in female patients.
abstract: Schizophrenia is a persistent chronic mental illness with an unknown pathogenic mechanism; no empirical laboratory-based tests are available to support the diagnosis of schizophrenia or to identify biomarkers correlated with the therapeutic effect of olanzapine. For this study, 15 female first-episode, drug-naïve patients with schizophrenia and 15 healthy female volunteers were recruited. Tests for blood glucose and lipids were conducted at baseline and after 4 weeks of treatment with olanzapine. UPLC-MS based metabonomic analysis was performed on both case and control groups to identify biomarkers of schizophrenia at baseline and to explore which biomarkers correlated with the therapeutic effect of olanzapine after a 4-week treatment. Compared with the control group, the case group showed significant changes in plasma metabolites. Thirteen distinct metabolites were identified. Among all the therapeutically effective cases, levels of these metabolites appeared to shift towards the normal trend; 8 of the identified 13 metabolites changed dramatically. The metabolites that we found are potential biomarkers for the diagnosis and treatment of schizophrenia.
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China. Electronic address: qiaoying_1978@aliyun.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China. Electronic address: 18817821815@163.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China. Electronic address: shenhe0204@126.com.
authors.forename: Shen
authors.initials: S
authors.lastname: He
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China. Electronic address: wenhui_1996smhc@163.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Wen
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China. Electronic address: 13901856492@163.com.
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Yu
authors.affiliation: Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, PR China. Electronic address: caoyilily@126.com.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Cao
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China. Electronic address: qy20140930@yeah.net.
authors.forename: Hua-Fang
authors.initials: HF
authors.lastname: Li
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D054316:Biomarkers, Pharmacological / Q000097:blood; D016022:Case-Control Studies; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D055442:Metabolome; D000077152:Olanzapine; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D054316:Biomarkers, Pharmacological; D001569:Benzodiazepines; D000077152:Olanzapine
keywords: Metabonomics; Olanzapine; Schizophrenia; UPLC–MS