title: [Research Advances on Treatment of Multiple Myeloma Bone Disease--Review].
abstract: The main features of multiple myeloma bone disease (MBD) are hyperactivity of systemic bone destruction and inhibition of new bone formation. Its clinical manifestations include pain, osteoporosis, pathologic fractures and associated nerve compression symptoms etc. MBD is one of the most common complications of multiple myeloma (MM). Its misdiagnosis rate is higher, and the patients' quality of life and prognosis are poor. This review discusses the most recent advancement on its pathogenesis and novel therapies, so as to provide reference for clinical treatment of MBD.
authors.affiliation: Department of Hematology and Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, Jiangsu Province, China.
authors.forename: Zu-Yao
authors.initials: ZY
authors.lastname: Xia
authors.affiliation: Department of Hematology and Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, Jiangsu Province, China.|Department of Hematology and Oncology, The People's Hospital of Danyang, Danyang 212300, Jiangsu Province, China.
authors.forename: Hui-Juan
authors.initials: HJ
authors.lastname: Yang
authors.affiliation: Department of Hematology and Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, Jiangsu Province, China. E-mail: cba8888@hotmail.com; bachen@seu.edu.cn.
authors.forename: Bao-An
authors.initials: BA
authors.lastname: Chen
mesh_terms: D001847:Bone Diseases / Q000150:complications / Q000628:therapy*; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications / Q000628:therapy*; D011379:Prognosis; D011788:Quality of Life