title: Long-lasting Remission Induced by Syngeneic Haematopoietic Stem Cell Transplantation in a Patient with Refractory Crohn's Disease.
abstract: OBJECTIVE
  Autologous haematopoietic stem cell transplantation (HSCT) is considered a salvage therapy for patients with refractory immune-mediated diseases. Syngeneic HSCT may be an alternative to autologous HSCT, with potential advantages in terms of safety and efficacy.
  
  
  METHODS
  A patient with severe Crohn's disease refractory to available medical therapies underwent a syngeneic HSCT from her identical twin sister. Cyclophosphamide and rabbit anti-thymocyte globulin were administered for conditioning.
  
  
  RESULTS
  After transplant, the patient presented successful engraftment, complete haematological and immunological reconstitution, and no severe complications. The patient achieved complete remission after transplant which is sustained 4 years after transplantation without any active treatment for Crohn's disease.
  
  
  CONCLUSIONS
  Patients with refractory immune-mediated diseases who have an identical disease-free twin may benefit from a syngeneic HSCT.
authors.affiliation: Gastroenterology Department, Hospital Clínic a, IDIBAPS, CIBERehd, Barcelona, Spain.
authors.forename: Aranzazu
authors.initials: A
authors.lastname: Jauregui-Amezaga
authors.affiliation: Haematology Department, Hospital Clínic, Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Rovira
authors.affiliation: Gastroenterology Department, Hospital Clínic a, IDIBAPS, CIBERehd, Barcelona, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: López
authors.affiliation: Haemotherapy and Haemostasis Department, Hospital Clínic, Barcelona, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Marín
authors.affiliation: Radiology Department, Hospital Clinic, Barcelona, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Rodriguez
authors.affiliation: Radiology Department, Hospital Clinic, Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Rimola
authors.affiliation: Gastroenterology Department, Hospital Clínic a, IDIBAPS, CIBERehd, Barcelona, Spain.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Ordás
authors.affiliation: Gastroenterology Department, Hospital Clínic a, IDIBAPS, CIBERehd, Barcelona, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Alfaro
authors.affiliation: Gastroenterology Department, Hospital Clínic a, IDIBAPS, CIBERehd, Barcelona, Spain.
authors.forename: Julian
authors.initials: J
authors.lastname: Panés
authors.affiliation: Gastroenterology Department, Hospital Clínic a, IDIBAPS, CIBERehd, Barcelona, Spain ericart@clinic.ub.es.
authors.forename: Elena
authors.initials: E
authors.lastname: Ricart
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000628:therapy*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D012074:Remission Induction; D014185:Transplantation, Isogeneic; D014427:Twins
keywords: Clinical trials; endoscopy; quality of life; socioeconomic and psychological end points