title: Essential fatty acid-rich diets protect against striatal oxidative damage induced by quinolinic acid in rats.
abstract: Essential fatty acids have an important effect on oxidative stress-related diseases. The Huntington's disease (HD) is a hereditary neurologic disorder in which oxidative stress caused by free radicals is an important damage mechanism. The HD experimental model induced by quinolinic acid (QUIN) has been widely used to evaluate therapeutic effects of antioxidant compounds. The aim of this study was to test whether the fatty acid content in olive- or fish-oil-rich diet prevents against QUIN-related oxidative damage in rats. Rats were fed during 20 days with an olive- or a fish-oil-rich diet (15% w/w). Posterior to diet period, rats were striatally microinjected with QUIN (240 nmol/µl) or saline solution. Then, we evaluated the neurological damage, oxidative status, and gamma isoform of the peroxisome proliferator-activated receptor (PPARγ) expression. Results showed that fatty acid-rich diet, mainly by fish oil, reduced circling behavior, prevented the fall in GABA levels, increased PPARγ expression, and prevented oxidative damage in striatal tissue. In addition none of the enriched diets exerted changes neither on triglycerides or cholesterol blood levels, nor or hepatic function. This study suggests that olive- and fish-oil-rich diets exert neuroprotective effects.
authors.affiliation: a Departamento de Neuroquímica , Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez" , Insurgentes Sur #3877, Col. La Fama, Tlalpan, 14269 México D.F. , México.|b Laboratorio de Investigación de Bioquímica y Biofísica Computacional , Escuela Nacional de Medicina y de Homeopatía del IPN , Guillermo Massieu H. #239. La Escalera, Gustavo A. Madero, 07320 México D.F. , México.
authors.forename: Adriana
authors.initials: A
authors.lastname: Morales-Martínez
authors.affiliation: c Departamento de Farmacología , Instituto Nacional de Cardiología "Ignacio Chávez" , Juan Badiano #1, Col. Sección XVI, Tlalpan, México D.F. , México.
authors.forename: Alicia
authors.initials: A
authors.lastname: Sánchez-Mendoza
authors.affiliation: d Departamento de Neurofisiología , Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez" , Insurgentes Sur #3877, Col. La Fama, Tlalpan, 14269 México D.F. , México.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Martínez-Lazcano
authors.affiliation: a Departamento de Neuroquímica , Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez" , Insurgentes Sur #3877, Col. La Fama, Tlalpan, 14269 México D.F. , México.
authors.forename: Jorge Baruch
authors.initials: JB
authors.lastname: Pineda-Farías
authors.affiliation: a Departamento de Neuroquímica , Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez" , Insurgentes Sur #3877, Col. La Fama, Tlalpan, 14269 México D.F. , México.
authors.forename: Sergio
authors.initials: S
authors.lastname: Montes
authors.affiliation: e Departamento de Biomedicina Cardiovascular , Instituto Nacional de Cardiología "Ignacio Chávez" , Juan Badiano 1, Col. Sección XVI. Tlalpan, México D.F. , México.
authors.forename: Mohammed
authors.initials: M
authors.lastname: El-Hafidi
authors.affiliation: a Departamento de Neuroquímica , Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez" , Insurgentes Sur #3877, Col. La Fama, Tlalpan, 14269 México D.F. , México.
authors.forename: Pablo Eliasib
authors.initials: PE
authors.lastname: Martínez-Gopar
authors.affiliation: a Departamento de Neuroquímica , Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez" , Insurgentes Sur #3877, Col. La Fama, Tlalpan, 14269 México D.F. , México.
authors.forename: Luis
authors.initials: L
authors.lastname: Tristán-López
authors.affiliation: a Departamento de Neuroquímica , Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez" , Insurgentes Sur #3877, Col. La Fama, Tlalpan, 14269 México D.F. , México.
authors.forename: Iván
authors.initials: I
authors.lastname: Pérez-Neri
authors.affiliation: b Laboratorio de Investigación de Bioquímica y Biofísica Computacional , Escuela Nacional de Medicina y de Homeopatía del IPN , Guillermo Massieu H. #239. La Escalera, Gustavo A. Madero, 07320 México D.F. , México.
authors.forename: Absalom
authors.initials: A
authors.lastname: Zamorano-Carrillo
authors.affiliation: f Laboratorio de Neuropsicofarmacología , Instituto Nacional de Neurología y Neurocirugía , Insurgentes sur 3877, La Fama, Tlalpan, 14269 México D.F. , México.
authors.forename: Nelly
authors.initials: N
authors.lastname: Castro
authors.affiliation: a Departamento de Neuroquímica , Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez" , Insurgentes Sur #3877, Col. La Fama, Tlalpan, 14269 México D.F. , México.
authors.forename: Camilo
authors.initials: C
authors.lastname: Ríos
authors.affiliation: a Departamento de Neuroquímica , Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez" , Insurgentes Sur #3877, Col. La Fama, Tlalpan, 14269 México D.F. , México.
authors.forename: Francisca
authors.initials: F
authors.lastname: Pérez-Severiano
mesh_terms: D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D005228:Fatty Acids, Essential / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology; D006816:Huntington Disease / Q000188:drug therapy; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology; D000069463:Olive Oil / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D017378:Quinolinic Acid / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005228:Fatty Acids, Essential; D005395:Fish Oils; D018696:Neuroprotective Agents; D000069463:Olive Oil; D014280:Triglycerides; D005680:gamma-Aminobutyric Acid; D002784:Cholesterol; D017378:Quinolinic Acid
keywords: Essential fatty acids; Fish oil; Huntington's disease; Olive oil; Oxidative damage