title: Effect of asymmetric dimethylarginine (ADMA) on heart failure development.
abstract: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases that limits nitric oxide bioavailability and can increase production of NOS derived reactive oxidative species. Increased plasma ADMA is a one of the strongest predictors of mortality in patients who have had a myocardial infarction or suffer from chronic left heart failure, and is also an independent risk factor for several other conditions that contribute to heart failure development, including hypertension, coronary artery disease/atherosclerosis, diabetes, and renal dysfunction. The enzyme responsible for ADMA degradation is dimethylarginine dimethylaminohydrolase-1 (DDAH1). DDAH1 plays an important role in maintaining nitric oxide bioavailability and preserving cardiovascular function in the failing heart. Here, we examine mechanisms of abnormal NO production in heart failure, with particular focus on the role of ADMA and DDAH1.
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Liu
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Hou
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
authors.forename: Dachun
authors.initials: D
authors.lastname: Xu
authors.affiliation: Cardiovascular Division and Lillehei Heart Institute, University of Minnesota, MN55455, USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Chen
authors.affiliation: Cardiovascular Division and Lillehei Heart Institute, University of Minnesota, MN55455, USA.
authors.forename: Liuqing
authors.initials: L
authors.lastname: Yang
authors.affiliation: Cardiovascular Division and Lillehei Heart Institute, University of Minnesota, MN55455, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhuang
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Pharmacology and Toxicology, University of Graz, Graz, 8020, Austria. Electronic address: john.fassett@uni-graz.at.
authors.forename: John T
authors.initials: JT
authors.lastname: Fassett
authors.affiliation: Cardiovascular Division and Lillehei Heart Institute, University of Minnesota, MN55455, USA. Electronic address: chenx106@umn.edu.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000581:Amidohydrolases / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism; D006333:Heart Failure / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D030421:Peroxynitrous Acid / Q000378:metabolism; D015398:Signal Transduction; D013481:Superoxides / Q000378:metabolism; D019323:omega-N-Methylarginine / Q000378:metabolism
chemical_list: D013481:Superoxides; D030421:Peroxynitrous Acid; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; C018524:N,N-dimethylarginine; D001120:Arginine; D019001:Nitric Oxide Synthase; D000581:Amidohydrolases; C059999:dimethylargininase
keywords: Asymmetric dimethylarginine; Dimethylarginine dimethylaminohydrolase-1; Heart failure; Nitric oxide