title: [Significance of ST2 in the Early Diagnosis and Treatment of Graft-Versus-Host Disease--Review].
abstract: Graft-versus-host disease (GVHD) is a major complication of allo-hematopoietic stem cell transplantation. It is reported that IL-2R, TNFR1, elafin (for skin GVHD) and REG-3α (for gastrointestinal GVHD) can be used in the early diagnosis of acute GVHD, but they cannot predict the response to therapy independently. Therefore, it is urgent to find a biomarker to predict GVHD and glucocorticoid resistance. ST2 is a member of IL-1 receptor family and specially binds to IL-33. Researchers have found that higher ST2 level is associated with increased GVHD risk, glucocorticoid resistance and transplantation-related mortality. This review focuses on the structure, function, signal transduction pathway of ST2/IL-33, and its roles in diagnosis and treatment of autoimmune diseases and GVHD.
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors.forename: Run-Qing
authors.initials: RQ
authors.lastname: Lu
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China. E-mail: gh7311@aliyun.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Guo
mesh_terms: D001327:Autoimmune Diseases; D015415:Biomarkers; D042241:Early Diagnosis; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D017472:Receptors, Interleukin-1 / Q000378:metabolism*; D014184:Transplantation, Homologous
chemical_list: D015415:Biomarkers; D017472:Receptors, Interleukin-1