title: Protein requirement in critical illness.
abstract: How much protein do critically ill patients require? For the many decades that nutritional support has been used there was a broad consensus that critically ill patients need much more protein than required for normal health. Now, however, some clinical investigators recommend limiting all macronutrient provision during the early phase of critical illness. How did these conflicting recommendations emerge? Which of them is correct? This review explains the longstanding recommendation for generous protein provision in critical illness, analyzes the clinical trials now being claimed to refute it, and concludes with suggestions for clinical investigation and practice.
authors.affiliation: Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote-Ste-Catherine Road, McGill University, Montreal, QC H3T 1E2, Canada.|Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote-Ste-Catherine Road, McGill University, Montreal, QC H3T 1E2, Canada.
authors.forename: Leonard John
authors.initials: LJ
authors.lastname: Hoffer
mesh_terms: D002986:Clinical Trials as Topic; D016638:Critical Illness / Q000628:therapy*; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000032:analysis; D002149:Energy Intake; D006801:Humans; D007362:Intensive Care Units; D009751:Nutritional Requirements; D018529:Nutritional Support; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors
chemical_list: D004044:Dietary Proteins
keywords: besoins nutritifs; besoins protéiques; biais; bias; calories; critical care; critical illness; energy; enteral nutrition; maladie grave; nutrition entérale; nutrition parentérale; nutrition requirements; nutritional support; parenteral nutrition; protein requirements; soins intensifs; soutien nutritif; énergie