title: A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.
abstract: Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores of 23.5 vs 46.3), more rapid resolution of clinical disease (20 hours earlier), reduced viral shedding (total median tissue culture infectious dose [TCID50] 7.4 vs 9.7), and significantly reduced expression of several inflammatory cytokines (interferon-γ, tumor necrosis factor-α, interleukin-6, and others). The host genomic response to influenza infection is robust and may provide the means for early detection, more timely therapeutic interventions, a meaningful reduction in clinical disease, and an effective molecular means to track response to therapy.
authors.affiliation: Center for Applied Genomics and Precision Medicine, Duke University; Durham Veterans Affairs Medical Center; Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina.
authors.forename: Micah T
authors.initials: MT
authors.lastname: McClain
authors.affiliation: Durham Veterans Affairs Medical Center.
authors.forename: Bradly P
authors.initials: BP
authors.lastname: Nicholson
authors.affiliation: Durham Veterans Affairs Medical Center; Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina.
authors.forename: Lawrence P
authors.initials: LP
authors.lastname: Park
authors.affiliation: Department of Electrical Engineering and Computer Sciences, University of California, Berkeley; National Center for Genome Resources, Santa Fe, New Mexico.
authors.forename: Tzu-Yu
authors.initials: TY
authors.lastname: Liu
authors.affiliation: Center for Computational Biology and Bioinformatics , University of Michigan , Ann Arbor.
authors.forename: Alfred O
authors.initials: AO
authors.lastname: Hero
authors.affiliation: Center for Applied Genomics and Precision Medicine, Duke University; Durham Veterans Affairs Medical Center; Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina.
authors.forename: Ephraim L
authors.initials: EL
authors.lastname: Tsalik
authors.affiliation: Center for Applied Genomics and Precision Medicine, Duke University; Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina.
authors.forename: Aimee K
authors.initials: AK
authors.lastname: Zaas
authors.affiliation: Center for Applied Genomics and Precision Medicine , Duke University.
authors.forename: Timothy
authors.initials: T
authors.lastname: Veldman
authors.affiliation: Center for Applied Genomics and Precision Medicine , Duke University.
authors.forename: Lori L
authors.initials: LL
authors.lastname: Hudson
authors.affiliation: hVIVO , London , United Kingdom.
authors.forename: Robert
authors.initials: R
authors.lastname: Lambkin-Williams
authors.affiliation: hVIVO , London , United Kingdom.
authors.forename: Anthony
authors.initials: A
authors.lastname: Gilbert
authors.affiliation: Center for Applied Genomics and Precision Medicine , Duke University.
authors.forename: Thomas
authors.initials: T
authors.lastname: Burke
authors.affiliation: Center for Applied Genomics and Precision Medicine , Duke University.
authors.forename: Marshall
authors.initials: M
authors.lastname: Nichols
authors.affiliation: Center for Applied Genomics and Precision Medicine , Duke University.
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Ginsburg
authors.affiliation: Center for Applied Genomics and Precision Medicine, Duke University; Durham Veterans Affairs Medical Center; Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Woods
keywords: gene expression; genomic; influenza; oseltamivir