title: Treatment of patients with metastatic pancreatic cancer: Experience from a tertiary Indian cancer center.
abstract: BACKGROUND
  The aim of this study was to look at the outcome of patients with metastatic pancreatic cancer treated at a tertiary cancer center in India.
  
  
  METHODS
  A total of 101 patients with locally advanced and metastatic pancreatic cancer diagnosed between May 2012 and July 2013 were identified from a prospectively maintained database at the tertiary cancer center. Overall survival (OS) was computed using the Kaplan-Meir product limit method and compared across groups using the log-rank statistics. Cox proportional hazards model, adjusted for a number of patient and tumor characteristics, was then used to determine factors prognostic for OS.
  
  
  RESULTS
  Median age at diagnosis was 55 years (range: 21-81 years). 57.4% (n = 58) of patients were male, 22% (n = 22) had performance status (PS) of <2 at diagnosis and 89% received first-line chemotherapy, while the rest received best supportive care. For the whole cohort, 6 month and 1-year OS was 57% (95% confidence interval [CI]: 46-66%) and 47% (95% CI: 35-57%), respectively. In a multivariable model, PS <2 and oligometastatic disease were associated with a significantly decreased risk of death.
  
  
  CONCLUSIONS
  Results from our analysis indicate that the prognostic outcome among Indian patients with metastatic pancreatic cancer is poor with survival outcomes similar to those reported in North America and Europe.
authors.affiliation: Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.
authors.forename: B
authors.initials: B
authors.lastname: Sirohi
authors.forename: S
authors.initials: S
authors.lastname: Dawood
authors.forename: S
authors.initials: S
authors.lastname: Rastogi
authors.forename: A
authors.initials: A
authors.lastname: Pandey
authors.forename: M
authors.initials: M
authors.lastname: Bal
authors.forename: N
authors.initials: N
authors.lastname: Shetty
authors.forename: S V
authors.initials: SV
authors.lastname: Shrikhande
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D011446:Prospective Studies; D062606:Tertiary Care Centers; D055815:Young Adult