title: The effect of testosterone treatment on prostate histology and apoptosis in men with late-onset hypogonadism.
abstract: OBJECTIVE
  To investigate the effect of testosterone replacement therapy (TRT) on prostate histology and apoptosis in men with late-onset hypogonadism (LOH).
  
  
  METHODS
  The study included 25 men, having LOH with prostate-specific antigen (PSA) level of 4 ng/ml or less. All patients underwent transrectal ultrasound guided prostate biopsy at baseline, and received testosterone undecanoate treatment for 1 year. Prostate biopsy was repeated at the end of 1 year of testosterone therapy. In addition to clinical and biochemical parameters, prostate histology and apoptotic index (AI) were compared before and after the TRT.
  
  
  RESULTS
  The mean serum total testosterone significantly increased from 178.04 ± 51.92 to 496.28 ± 103.73 ng/dl (p = 0.001). No significant differences were observed in serum total and free PSA level, prostate volume and maximal urinary flow rate. There were also no significant differences in AI, stroma/epithelial cells ratio, Ki-67 positive cells and atrophy score of prostate tissue before and after the TRT.
  
  
  CONCLUSIONS
  This study demonstrated that TRT did not affect serum PSA level, prostate volume and maximal urinary flow rate. This study also suggests that TRT does not cause the risk for prostate cancer development, because of no significant differences in prostate histology after TRT.
authors.affiliation: a Department of Urology , University of Mersin School of Medicine , Mersin , Turkey and.
authors.forename: Ozan
authors.initials: O
authors.lastname: Efesoy
authors.affiliation: b Department of Pathology , University of Mersin School of Medicine , Mersin , Turkey.
authors.forename: Duygu
authors.initials: D
authors.lastname: Apa
authors.affiliation: a Department of Urology , University of Mersin School of Medicine , Mersin , Turkey and.
authors.forename: Mesut
authors.initials: M
authors.lastname: Tek
authors.affiliation: a Department of Urology , University of Mersin School of Medicine , Mersin , Turkey and.
authors.forename: Selahittin
authors.initials: S
authors.lastname: Çayan
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000187:drug effects*; D001706:Biopsy; D005058:Eunuchism / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood; D013739:Testosterone / Q000097:blood / Q000627:therapeutic use*
chemical_list: D013739:Testosterone; D017430:Prostate-Specific Antigen
keywords: AMS; IIEF; LUTS; Testosterone; prostate cancer; prostate volume