title: Acute Fibrinolysis Shutdown after Injury Occurs Frequently and Increases Mortality: A Multicenter Evaluation of 2,540 Severely Injured Patients.
abstract: BACKGROUND
  Fibrinolysis is a physiologic process that maintains microvascular patency by breaking down excessive fibrin clot. Hyperfibrinolysis is associated with a doubling of mortality. Fibrinolysis shutdown, an acute impairment of fibrinolysis, has been recognized as a risk factor for increased mortality. The purpose of this study was to assess the incidence and outcomes of fibrinolysis phenotypes in 2 urban trauma centers.
  
  
  METHODS
  Injured patients included in the analysis were admitted between 2010 and 2013, were 18 years of age or older, and had an Injury Severity Score (ISS) > 15. Admission fibrinolysis phenotypes were determined by the clot lysis at 30 minutes (LY30): shutdown ≤ 0.8%, physiologic 0.9% to 2.9%, and hyperfibrinolysis ≥ 3%. Logistic regression was used to adjust for age, arrival blood pressure, ISS, mechanism, and facility.
  
  
  RESULTS
  There were 2,540 patients who met inclusion criteria. Median age was 39 years (interquartile range [IQR] 26 to 55 years) and median ISS was 25 (IQR 20 to 33), with a mortality rate of 21%. Fibrinolysis shutdown was the most common phenotype (46%) followed by physiologic (36%) and hyperfibrinolysis (18%). Hyperfibrinolysis was associated with the highest death rate (34%), followed by shutdown (22%), and physiologic (14%, p < 0.001). The risk of mortality remained increased for hyperfibrinolysis (odds ratio [OR] 3.3, 95% CI 2.4 to 4.6, p < 0.0001) and shutdown (OR 1.6, 95% CI 1.3 to 2.1, p = 0.0003) compared with physiologic when adjusting for age, ISS, mechanism, head injury, and blood pressure (area under the receiver operating characteristics curve 0.82, 95% CI 0.80 to 0.84).
  
  
  CONCLUSIONS
  Fibrinolysis shutdown is the most common phenotype on admission and is associated with increased mortality. These data provide additional evidence of distinct phenotypes of coagulation impairment and that individualized hemostatic therapy may be required.
authors.affiliation: Department of Surgery, University of Colorado Denver/Denver Health Medical Center, Denver, CO. Electronic address: hunter.moore@ucdenver.edu.
authors.forename: Hunter B
authors.initials: HB
authors.lastname: Moore
authors.affiliation: Department of Surgery, University of Colorado Denver/Denver Health Medical Center, Denver, CO.
authors.forename: Ernest E
authors.initials: EE
authors.lastname: Moore
authors.affiliation: Department of Surgery, University of Texas Health Science Center at Houston/Memorial Hermann, Houston, TX.
authors.forename: Ioannis N
authors.initials: IN
authors.lastname: Liras
authors.affiliation: Department of Surgery, University of Colorado Denver/Denver Health Medical Center, Denver, CO.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gonzalez
authors.affiliation: Department of Surgery, University of Texas Health Science Center at Houston/Memorial Hermann, Houston, TX.
authors.forename: John A
authors.initials: JA
authors.lastname: Harvin
authors.affiliation: Department of Surgery, University of Texas Health Science Center at Houston/Memorial Hermann, Houston, TX.
authors.forename: John B
authors.initials: JB
authors.lastname: Holcomb
authors.affiliation: Department of Surgery, University of Colorado Denver/Denver Health Medical Center, Denver, CO.
authors.forename: Angela
authors.initials: A
authors.lastname: Sauaia
authors.affiliation: Department of Surgery, University of Texas Health Science Center at Houston/Memorial Hermann, Houston, TX.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Cotton
mesh_terms: D000208:Acute Disease; D000328:Adult; D015331:Cohort Studies; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D015601:Injury Severity Score; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013916:Thrombelastography; D014193:Trauma Centers; D014947:Wounds and Injuries / Q000175:diagnosis / Q000401:mortality* / Q000503:physiopathology*; D055815:Young Adult