title: Effect of Hydroxyethyl Starch on Acute Kidney Injury After Living Donor Hepatectomy.
abstract: BACKGROUND
  Concerns about the adverse effects of hydroxyethyl starch (HES) on renal function have been raised in recent studies involving critically ill patients. We aimed to evaluate the effect of HES on acute kidney injury (AKI) after living donor right hepatectomy.
  
  
  METHODS
  We performed a 1:3 propensity score matching analysis of the medical records of 1641 living donors who underwent a donor right hepatectomy. They were divided into the control group (n = 60), who received only crystalloids, and the colloid group (n = 1,581), who received HES 130/0.4 and crystalloids. Postoperative AKI was determined by AKI Network (AKIN) and Risk, Injury, Failure, Loss, End-stage (RIFLE) criteria.
  
  
  RESULTS
  A 1:3 propensity score matching was performed in 206 donors, 54 donors in the control group and 152 donors in the colloid group. For the matched colloid group, the median amount of 7.65 mL/kg (interquartile range, 6.64-9.20) of colloid and 58.19 mL/kg (interquartile range, 45.63-71.51) of crystalloid were given. The median amount of administered crystalloid in the control group was 56.48 mL/kg (interquartile range, 47.94-76.12) after propensity score matching. The incidences of AKI were not different between the control and colloid groups (P = .460 by AKIN criteria; P = .999 by RIFLE criteria).
  
  
  CONCLUSIONS
  Intraoperative administration of HES may not be associated with AKI after living donor hepatectomy. This result can provide useful information on perioperative fluid management in living liver donors.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: S-K
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: S-S
authors.initials: SS
authors.lastname: Choi
authors.affiliation: Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: J-H
authors.initials: JH
authors.lastname: Sim
authors.affiliation: Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: J
authors.initials: J
authors.lastname: Baik
authors.affiliation: Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: S
authors.initials: S
authors.lastname: Hwang
authors.affiliation: Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: S-G
authors.initials: SG
authors.lastname: Lee
authors.affiliation: Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: kyk@amc.seoul.kr.
authors.forename: Y-K
authors.initials: YK
authors.lastname: Kim
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000453:epidemiology; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D000077324:Crystalloid Solutions; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000009:adverse effects*; D015994:Incidence; D007552:Isotonic Solutions / Q000009:adverse effects; D016031:Liver Transplantation / Q000379:methods; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000009:adverse effects*; D011184:Postoperative Period; D057216:Propensity Score; D020858:Tissue and Organ Harvesting / Q000379:methods*
chemical_list: D000077324:Crystalloid Solutions; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D010952:Plasma Substitutes