title: Staphylococcus aureus and Streptococcus pneumoniae interaction and response to pneumococcal vaccination: Myth or reality?
abstract: S. aureus and S. pneumoniae are both common pathogens that are also carried by a large proportion of healthy individuals in the nasal and nasopharyngeal spaces. A negative association between carriage of S. aureus and S. pneumoniae has been reported in children in various epidemiologic studies from different geographical regions. Most studies found that the negative association between S. pneumoniae and S. aureus was significant only for carriage of vaccine-type S. pneumoniae strains. In this review, we summarize the various suggested mechanisms of this suggested bacterial interference, and the clinical implications reported following PCV introduction to date in various geographical regions.
authors.affiliation: a Epidemiology of Infectious Diseases Section; Gertner Institute ; Tel-Hashomer , Israel.|b Infectious Dis. Unit; Sheba Medical Center; Ramat-Gan; Affiliated to the Sackler School of Medicine; Tel-Aviv University ; Tel Aviv , Israel.
authors.forename: Aylana
authors.initials: A
authors.lastname: Reiss-Mandel
authors.affiliation: a Epidemiology of Infectious Diseases Section; Gertner Institute ; Tel-Hashomer , Israel.|b Infectious Dis. Unit; Sheba Medical Center; Ramat-Gan; Affiliated to the Sackler School of Medicine; Tel-Aviv University ; Tel Aviv , Israel.
authors.forename: Gili
authors.initials: G
authors.lastname: Regev-Yochay
mesh_terms: D000898:Antibiosis / Q000235:genetics / Q000502:physiology*; D002353:Carrier State / Q000382:microbiology; D002675:Child, Preschool; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007223:Infant; D064307:Microbiota / Q000276:immunology*; D009305:Nasopharynx / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000382:microbiology; D022242:Pneumococcal Vaccines / Q000276:immunology; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D022242:Pneumococcal Vaccines; D006861:Hydrogen Peroxide