title: The molecular pathogenesis of chronic lymphocytic leukaemia.
abstract: Recent investigations have provided an increasingly complete picture of the genetic landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL genome displays a high degree of heterogeneity between patients and within the same patient. In addition, they highlighted molecular mechanisms and functionally relevant biological programmes that may be important for the pathogenesis and therapeutic targeting of this disease. This Review focuses on recent insights into the understanding of CLL biology, with emphasis on the role of genetic lesions in the initiation and clinical progression of CLL. We also consider the translation of these findings into the development of risk-adapted and targeted therapeutic approaches.
authors.affiliation: Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA.|Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.
authors.forename: Giulia
authors.initials: G
authors.lastname: Fabbri
authors.affiliation: Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA.|Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.|Department of Pathology and Cell Biology and New York, New York 10032, USA.|Departments of Genetics and Development and Microbiology and Immunology, Columbia University, New York, New York 10032, USA.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Dalla-Favera
mesh_terms: D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology / Q000628:therapy