title: Identification of lysocin E using a silkworm model of bacterial infection.
abstract: New antimicrobials with novel mechanisms need to be developed to combat antimicrobial-resistant pathogenic bacteria. The current authors recently reported discovery of a new antibiotic named "Lysocin E". Lysocin E was identified using a silkworm model of bacterial infection. The current review discusses the advantages of using a silkworm model of bacterial infection to identify and develop therapeutically efficacious antimicrobials. This review also discusses the discovery of lysocin E and its novel mechanism of action.
authors.affiliation: Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hamamoto
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sekimizu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D012831:Bombyx / Q000187:drug effects* / Q000196:embryology / Q000382:microbiology; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007814:Larva / Q000187:drug effects / Q000382:microbiology; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000494:pharmacology*; D013045:Species Specificity
chemical_list: D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; C000597008:lysocin E