title: Central Diabetes Insipidus and Cisplatin-Induced Renal Salt Wasting Syndrome: A Challenging Combination.
abstract: We describe a 2-year-old female with a suprasellar primitive neuroectodermal tumor and central diabetes insipidus (DI) who developed polyuria with natriuresis and subsequent hyponatremia 36 hr after cisplatin administration. The marked urinary losses of sodium in combination with a negative sodium balance led to the diagnosis of cisplatin-induced renal salt wasting syndrome (RSWS). The subsequent clinical management is very challenging. Four weeks later she was discharged from ICU without neurological sequela. The combination of cisplatin-induced RSWS with DI can be confusing and needs careful clinical assessment as inaccurate diagnosis and management can result in increased neurological injury.
authors.affiliation: Paediatric Intensive Care Unit, Royal Children's Hospital, Melbourne, Australia.|Department of Paediatrics, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Gerard
authors.initials: G
authors.lastname: Cortina
authors.affiliation: Children's Cancer Centre, Royal Children's Hospital, Melbourne, Australia.
authors.forename: Jordan R
authors.initials: JR
authors.lastname: Hansford
authors.affiliation: Paediatric Intensive Care Unit, Royal Children's Hospital, Melbourne, Australia.
authors.forename: Trevor
authors.initials: T
authors.lastname: Duke
mesh_terms: D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D020790:Diabetes Insipidus, Neurogenic / Q000139:chemically induced / Q000175:diagnosis / Q000652:urine; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced / Q000175:diagnosis / Q000652:urine; D018242:Neuroectodermal Tumors, Primitive / Q000188:drug therapy*; D019282:Wasting Syndrome / Q000139:chemically induced / Q000175:diagnosis / Q000652:urine
chemical_list: D002945:Cisplatin
keywords: cerebral salt-wasting syndrome; diabetes insipidus; hyponatremia; renal salt-wasting syndrome; syndrome of inappropriate antidiuretic hormone secretion