title: Facile Synthesis of Natural Alkoxynaphthalene Analogues from Plant Alkoxybenzenes.
abstract: Analogues of the bioactive natural alkoxynaphthalene pycnanthulignene D were synthesized by an efficient method. The starting plant allylalkoxybenzenes (1) are easily available from the plant essential oils of sassafras, dill, and parsley. The target 1-arylalkoxynaphthalenes (5) exhibited antiproliferative activity in a phenotypic sea urchin embryo assay.
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, RAS , Leninsky Prospect, 47, 119991, Moscow, Russian Federation.
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Tsyganov
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, RAS , Leninsky Prospect, 47, 119991, Moscow, Russian Federation.
authors.forename: Mikhail M
authors.initials: MM
authors.lastname: Krayushkin
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, RAS , Leninsky Prospect, 47, 119991, Moscow, Russian Federation.
authors.forename: Leonid D
authors.initials: LD
authors.lastname: Konyushkin
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, RAS , Leninsky Prospect, 47, 119991, Moscow, Russian Federation.
authors.forename: Yuri A
authors.initials: YA
authors.lastname: Strelenko
authors.affiliation: Institute of Developmental Biology, RAS , Vavilov Street, 26, 119334, Moscow, Russian Federation.|Chemical Block Ltd. , 3 Kyriacou Matsi, 3723, Limassol, Cyprus.
authors.forename: Marina N
authors.initials: MN
authors.lastname: Semenova
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, RAS , Leninsky Prospect, 47, 119991, Moscow, Russian Federation.
authors.forename: Victor V
authors.initials: VV
authors.lastname: Semenov
mesh_terms: D028524:Anethum graveolens / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009822:Oils, Volatile; D028528:Petroselinum / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry; D027441:Sassafras / Q000737:chemistry; D012617:Sea Urchins / Q000187:drug effects / Q000196:embryology
chemical_list: D000970:Antineoplastic Agents; D017705:Lignans; D009822:Oils, Volatile; D010938:Plant Oils; C000610482:pycnanthulignene D