title: Organoids as an in vitro model of human development and disease.
abstract: The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique.
authors.affiliation: A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.
authors.forename: Aliya
authors.initials: A
authors.lastname: Fatehullah
authors.affiliation: A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.
authors.forename: Si Hui
authors.initials: SH
authors.lastname: Tan
authors.affiliation: A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.|Centre for Regenerative Medicine, 47 Little France Crescent, University of Edinburgh, Edinburgh, EH16 4TJ, UK.|Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore.
authors.forename: Nick
authors.initials: N
authors.lastname: Barker
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009940:Organoids / Q000166:cytology*; D055153:Stem Cell Niche / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology*