title: Association between adiponectin gene T45G polymorphism and nonalcoholic fatty liver disease risk: a meta-analysis.
abstract: Numerous epidemiological investigations have evaluated the association between adiponectin gene T45G polymorphism and risk of nonalcoholic fatty liver disease (NAFLD). However, the results of these studies have proven to be inconsistent. Therefore, we conducted a meta-analysis to obtain a more accurate estimation of this association. Published articles were retrieved from PubMed and Web of Science databases and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed- or random-effect models. Five case-control studies incorporating 597 cases and 701 controls were included in this meta-analysis. No association between adiponectin gene T45G polymorphism and NAFLD was established (TT vs GG: OR = 0.83, 95%CI = 0.37-1.86; TG vs GG: OR = 0.76, 95%CI = 0.33-1.79; dominant model: OR = 0.83, 95%CI = 0.37-1.84; recessive model: OR = 1.10, 95%CI = 0.69-1.76). Moreover, in a subgroup analysis, no significant correlation was found among Asian subjects. In conclusion, the T45G polymorphism of the adiponectin gene may not constitute an NAFLD risk factor. However, this needs to be further validated in single large well-designed future studies.
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: L Q
authors.initials: LQ
authors.lastname: Zhu
authors.affiliation: Department of Gastroenterology, Xinjiang Production and Construction Corps-Four Division Hospital, Yining, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Huo
authors.affiliation: Department of Gastroenterology, Xinjiang Production and Construction Corps-Four Division Hospital, Yining, China.
authors.forename: J
authors.initials: J
authors.lastname: Qin
authors.affiliation: Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: G Y
authors.initials: GY
authors.lastname: Yuan
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D044466:Asian People; D016022:Case-Control Studies; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D065626:Non-alcoholic Fatty Liver Disease / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin