title: Tubular electrodeposition of chitosan-carbon nanotube implants enriched with calcium ions.
abstract: A new approach for obtaining chitosan-carbon nanotube implants enriched with calcium ions in the form of tubular hydrogels is fostered. The intended application of the hydrogels is tissue engineering, especially peripheral nervous tissue regeneration. The fabrication method, based on an electrodeposition phenomenon, shows significant advantages over current solutions as implants can now be obtained rapidly at any required dimensions. Thus, it may open a new avenue to treat patients with peripheral nerve injuries. Either single walled or multiwalled carbon nanotubes enhance the mechanical properties of the tubular hydrogels. The controlled presence of calcium ions, sourced from hydroxyapatite, is also expected to augment the regenerative response. Because in vitro cytotoxic assays on mouse cell lines (L929 fibroblasts and mHippoE-18 hippocampal cells) as well as pro-inflammatory tests on THP-1XBlue™ cells show that the manufactured implants are biocompatible, we next intend to evaluate their immune- and nervous-safety on an animal model.
authors.affiliation: Department of Process Thermodynamics, Faculty of Process and Environmental Engineering, Lodz University of Technology, Wolczanska 213 Street, 90-924 Lodz, Poland. Electronic address: katarzyna.nawrotek@p.lodz.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Nawrotek
authors.affiliation: Department of Process Thermodynamics, Faculty of Process and Environmental Engineering, Lodz University of Technology, Wolczanska 213 Street, 90-924 Lodz, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Tylman
authors.affiliation: Department of Immunology and Infectious Biology, The Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16 Street, 90-237 Lodz, Poland.
authors.forename: Karolina
authors.initials: K
authors.lastname: Rudnicka
authors.affiliation: Department of Immunoparasitology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Łódź, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Gatkowska
authors.affiliation: Department of Process Thermodynamics, Faculty of Process and Environmental Engineering, Lodz University of Technology, Wolczanska 213 Street, 90-924 Lodz, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Balcerzak
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002118:Calcium / Q000737:chemistry*; D002460:Cell Line; D048271:Chitosan / Q000737:chemistry*; D017886:Durapatite; D004595:Electroplating; D020100:Hydrogels; D007477:Ions; D051379:Mice; D037742:Nanotubes, Carbon / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D007477:Ions; D037742:Nanotubes, Carbon; D048271:Chitosan; D017886:Durapatite; D002118:Calcium
keywords: Carbon nanotubes; Chitosan; Electrodeposition; Hydroxyapatite; Nerve regeneration