title: Effects of Bisphenol A on ion channels: Experimental evidence and molecular mechanisms.
abstract: Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) produced in huge quantities in the manufacture of polycarbonate plastics and epoxy resins. It is present in most humans in developed countries, acting as a xenoestrogen and it is considered an environmental risk factor associated to several diseases. Among the whole array of identified mechanisms by which BPA can interfere with physiological processes in living organisms, changes on ion channel activity is one of the most poorly understood. There is still little evidence about BPA regulation of ion channel expression and function. However, this information is key to understand how BPA disrupts excitable and non-excitable cells, including neurons, endocrine cells and muscle cells. This report is the result of a comprehensive literature review on the effects of BPA on ion channels. We conclude that there is evidence to say that these important molecules may be key end-points for EDCs acting as xenoestrogens. However, more research on channel-mediated BPA effects is needed. Particularly, mechanistic studies to unravel the pathophysiological actions of BPA on ion channels at environmentally relevant doses.
authors.affiliation: Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Spain.
authors.forename: Sergi
authors.initials: S
authors.lastname: Soriano
authors.affiliation: Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández de Elche, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Ripoll
authors.affiliation: Departamento de Biología Aplicada and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández de Elche, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Alonso-Magdalena
authors.affiliation: Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández de Elche, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Fuentes
authors.affiliation: Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández de Elche, Spain.
authors.forename: Ivan
authors.initials: I
authors.lastname: Quesada
authors.affiliation: Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández de Elche, Spain. Electronic address: nadal@umh.es.
authors.forename: Angel
authors.initials: A
authors.lastname: Nadal
authors.affiliation: Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Spain. Electronic address: juan.martinez-pinna@ua.es.
authors.forename: Juan
authors.initials: J
authors.lastname: Martinez-Pinna
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D052244:Endocrine Disruptors / Q000633:toxicity*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism*; D010636:Phenols / Q000633:toxicity*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D007473:Ion Channels; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: 17β-Estradiol; Bisphenol A; Endocrine disruptor; Environmental doses; Ion channel; Pancreatic β-cells