title: Adaptive planning strategy for high dose  rate prostate brachytherapy—a simulation  study on needle positioning errors.
abstract: The development of magnetic resonance (MR) guided high dose rate (HDR) brachytherapy for prostate cancer has gained increasing interest for delivering a high tumor dose safely in a single fraction. To support needle placement in the limited workspace inside the closed-bore MRI, a single-needle MR-compatible robot is currently under development at the University Medical Center Utrecht (UMCU). This robotic device taps the needle in a divergent way from a single rotation point into the prostate. With this setup, it is warranted to deliver the irradiation dose by successive insertions of the needle. Although robot-assisted needle placement is expected to be more accurate than manual template-guided insertion, needle positioning errors may occur and are likely to modify the pre-planned dose distribution.In this paper, we propose a dose plan adaptation strategy for HDR prostate brachytherapy with feedback on the needle position: a dose plan is made at the beginning of the interventional procedure and updated after each needle insertion in order to compensate for possible needle positioning errors. The introduced procedure can be used with the single needle MR-compatible robot developed at the UMCU. The proposed feedback strategy was tested by simulating complete HDR procedures with and without feedback on eight patients with different numbers of needle insertions (varying from 4 to 12). In of the cases tested, the number of clinically acceptable plans obtained at the end of the procedure was larger with feedback compared to the situation without feedback. Furthermore, the computation time of the feedback between each insertion was below 100 s which makes it eligible for intra-operative use.
authors.forename: M
authors.initials: M
authors.lastname: Borot de Battisti
authors.forename: B
authors.initials: B
authors.lastname: Denis de Senneville
authors.forename: M
authors.initials: M
authors.lastname: Maenhout
authors.forename: G
authors.initials: G
authors.lastname: Hautvast
authors.forename: D
authors.initials: D
authors.lastname: Binnekamp
authors.forename: J J W
authors.initials: JJ
authors.lastname: Lagendijk
authors.forename: M
authors.initials: M
authors.lastname: van Vulpen
authors.forename: M A
authors.initials: MA
authors.lastname: Moerland
mesh_terms: D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009339:Needles / Q000009:adverse effects; D056888:Patient Positioning; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D061106:Radiotherapy Setup Errors / Q000517:prevention & control*; D061089:Radiotherapy, Image-Guided / Q000009:adverse effects / Q000379:methods*