title: Circadian adaptation to cell injury stresses: a crucial interplay of BMAL1 and HSF1.
abstract: The circadian clock system confers daily anticipatory physiological processes with the ability to be reset by environmental cues. This "circadian adaptation system" (CAS), driven by cell-autonomous molecular clocks, orchestrates various rhythmic physiological processes in the entire body. Hence, the dysfunction of these clocks exacerbates various diseases, which may partially be due to the impairment of protective pathways. If this is the case, how does the CAS respond to cell injury stresses that are critical in maintaining health and life by evoking protective pathways? To address this question, here we review and discuss recent evidence revealing life-protective (pro-survival) molecular networks between clock (e.g., BMAL1, CLOCK, and PER2) and adaptation (e.g., HSF1, Nrf2, NF-κB, and p53) pathways, which are evoked by various cell injury stresses (e.g., heat, reactive oxygen species, and UV). The CK2 protein kinase-integrated interplay of the BMAL1 (clock) and HSF1 (heat-shock response) pathways is one of the crucial events in CAS.
authors.affiliation: Department of Physiology and Advanced Research Center for Medical Science, Toho University School of Medicine, 5-21-16 Ohmori-nishi Ohta-ku, Tokyo, 143-8540, Japan. tetamaru@med.toho-u.ac.jp.
authors.forename: Teruya
authors.initials: T
authors.lastname: Tamaru
authors.affiliation: Department of Physiology, Faculty of Medicine, Saitama Medical University, 38 Morohongo Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.|Molecular Clock Project, Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1241, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ikeda
mesh_terms: D056930:ARNTL Transcription Factors / Q000378:metabolism*; D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D057906:Circadian Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D056930:ARNTL Transcription Factors; D006360:Heat-Shock Proteins; D017382:Reactive Oxygen Species
keywords: Adaptation; Circadian clock; Heat shock; Oxidative stress; Protein kinase