title: Biological and pathological activities of interleukin-22.
abstract: Interleukin (IL)-22, a member of the IL-10 family, is a cytokine secreted by several types of immune cells including IL-22(+)CD4(+) T cells (Th22) and IL-22 expressing innate leukocytes (ILC22). Recent studies have demonstrated that IL-22 is a key component in mucosal barrier defense, tissue repair, epithelial cell survival, and proliferation. Furthermore, accumulating evidence has defined both protective and pathogenic properties of IL-22 in a number of conditions including autoimmune disease, infection, and malignancy. In this review, we summarize the expression and signaling pathway and functional characteristics of the IL-22 and IL-22 receptor axis in physiological and pathological scenarios and discuss the potential to target IL-22 signaling to treat human diseases.
authors.affiliation: Department of Surgery, University of Michigan School of Medicine, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA.
authors.forename: Mirna
authors.initials: M
authors.lastname: Perusina Lanfranca
authors.affiliation: Department of Surgery, University of Michigan School of Medicine, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA.|Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai, 200001, China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai, 200001, China.
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Fang
authors.affiliation: Department of Surgery, University of Michigan School of Medicine, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA. wzou@med.umich.edu.|The University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, 48109, USA. wzou@med.umich.edu.|Graduate Programs in Immunology and Tumor Biology, University of Michigan, Ann Arbor, MI, 48109, USA. wzou@med.umich.edu.
authors.forename: Weiping
authors.initials: W
authors.lastname: Zou
authors.affiliation: Department of Surgery, University of Michigan School of Medicine, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA. timofran@med.umich.edu.|The University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, 48109, USA. timofran@med.umich.edu.
authors.forename: Timothy
authors.initials: T
authors.lastname: Frankel
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000150:complications / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015551:Autoimmunity; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000209:etiology / Q000378:metabolism; D007378:Interleukins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D018123:Receptors, Interleukin / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D018123:Receptors, Interleukin; D000097043:Interleukin-22; C415369:interleukin-22 receptor
keywords: Autoimmune; Cancer; IL-22; IL-22BP; IL-22R; ILC22; Infection; T cell; Th22