title: Effectiveness and Safety of Imipenem-Clavulanate Added to an Optimized Background Regimen (OBR) Versus OBR Control Regimens in the Treatment of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis.
authors.affiliation: Division of Infection.
authors.forename: Simon
authors.initials: S
authors.lastname: Tiberi
authors.affiliation: Clinical Epidemiology and Medical Statistics Unit, Department of Biomedical Sciences, University of Sassari, Research, Medical Education and Professional Development Unit, AOU Sassari.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sotgiu
authors.affiliation: WHO Collaborating Centre for TB and Lung Diseases Public Health Consulting Group, Lugano, Switzerland.
authors.forename: Lia
authors.initials: L
authors.lastname: D'Ambrosio
authors.affiliation: WHO Collaborating Centre for TB and Lung Diseases.
authors.forename: Rosella
authors.initials: R
authors.lastname: Centis
authors.affiliation: University Center of Araraquara Hospital Nestor Goulart Reis, São Paulo State Secretary of Health, Brazil.
authors.forename: Marcos Abdo
authors.initials: MA
authors.lastname: Arbex
authors.affiliation: International Union against Tuberculosis and Lung Disease (The Union) MDR-TB Unit, Tuberculosis Division.
authors.forename: Edith
authors.initials: E
authors.lastname: Alarcon Arrascue
authors.affiliation: Departments of Clinical Pharmacy and Pharmacology.
authors.forename: Jan Willem
authors.initials: JW
authors.lastname: Alffenaar
authors.affiliation: MDR-TB Unit, Tuberculosis Division Pneumology Department, Hospital General de Gran Canaria "Dr. Negrin," Las Palmas de Gran Canaria, Spain.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Caminero
authors.affiliation: National Referral Centre for Mycobacteria, Athens Chest Hospital, Ministry of Health, Greece.
authors.forename: Mina
authors.initials: M
authors.lastname: Gaga
authors.affiliation: Respiratory Infectious Diseases Unit, National Institute for Infectious Diseases "L. Spallanzani," Rome.
authors.forename: Gina
authors.initials: G
authors.lastname: Gualano
authors.affiliation: Republican Research and Practical Centre for Pulmonology and Tuberculosis, Minsk.
authors.forename: Alena
authors.initials: A
authors.lastname: Skrahina
authors.affiliation: National Institute for TB, Lung Diseases and Thoracic Surgery, Vysne Hagy, Catholic University Ruzomberok, Ruzomberok, Slovakia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Solovic
authors.affiliation: University Department of Infectious and Tropical Diseases, World Health Organization Collaborating Centre for TB/HIV Coinfection and for TB Elimination, University of Brescia and Brescia Spedali Civili General Hospital.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Sulis
authors.affiliation: Unit of Infectious Diseases, Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna.
authors.forename: Marina
authors.initials: M
authors.lastname: Tadolini
authors.affiliation: National Tuberculosis Control Programme, Ministry of Health.
authors.forename: Valentina
authors.initials: V
authors.lastname: Alarcon Guizado
authors.affiliation: AOVV E. Morelli Hospital, Reference Hospital for MDR and HIV-TB, Sondalo.
authors.forename: Saverio
authors.initials: S
authors.lastname: De Lorenzo
authors.affiliation: National Tuberculosis Control Programme, Pulmonology Hospital Alfredo J. Valenzuela, Guayaquil, Ecuador.
authors.forename: Aurora Jazmín
authors.initials: AJ
authors.lastname: Roby Arias
authors.affiliation: International Union against Tuberculosis and Lung Disease (The Union), Paris, France.
authors.forename: Anna
authors.initials: A
authors.lastname: Scardigli
authors.affiliation: Pulmonary Diseases & Tuberculosis, University of Groningen, University Medical Center Groningen, TB Center Beatrixoord.
authors.forename: Onno W
authors.initials: OW
authors.lastname: Akkerman
authors.affiliation: Educational Institution, Grodno State Medical University, Belarus.
authors.forename: Alena
authors.initials: A
authors.lastname: Aleksa
authors.affiliation: Educational Institution, Grodno State Medical University, Belarus.
authors.forename: Janina
authors.initials: J
authors.lastname: Artsukevich
authors.affiliation: Republican Research and Practical Centre for Pulmonology and Tuberculosis, Minsk.
authors.forename: Vera
authors.initials: V
authors.lastname: Avchinko
authors.affiliation: University Center of Araraquara Hospital Nestor Goulart Reis, São Paulo State Secretary of Health, Brazil.
authors.forename: Eduardo Henrique
authors.initials: EH
authors.lastname: Bonini
authors.affiliation: National Tuberculosis Control Programme, Pulmonology Hospital Alfredo J. Valenzuela, Guayaquil, Ecuador.
authors.forename: Félix Antonio
authors.initials: FA
authors.lastname: Chong Marín
authors.affiliation: National Tuberculosis Control Programme, Pulmonology Hospital Alfredo J. Valenzuela, Guayaquil, Ecuador.
authors.forename: Lorena
authors.initials: L
authors.lastname: Collahuazo López
authors.affiliation: KNCV Tuberculosis Foundation, Den Haag, The Netherlands.
authors.forename: Gerard
authors.initials: G
authors.lastname: de Vries
authors.affiliation: Clinical Epidemiology and Medical Statistics Unit, Department of Biomedical Sciences, University of Sassari, Research, Medical Education and Professional Development Unit, AOU Sassari.
authors.forename: Simone
authors.initials: S
authors.lastname: Dore
authors.affiliation: Department of Respiratory Medicine, Queen Mary University.
authors.forename: Heinke
authors.initials: H
authors.lastname: Kunst
authors.affiliation: University Department of Infectious and Tropical Diseases, World Health Organization Collaborating Centre for TB/HIV Coinfection and for TB Elimination, University of Brescia and Brescia Spedali Civili General Hospital.
authors.forename: Alberto
authors.initials: A
authors.lastname: Matteelli
authors.affiliation: National Referral Centre for Mycobacteria, Athens Chest Hospital, Ministry of Health, Greece.
authors.forename: Charalampos
authors.initials: C
authors.lastname: Moschos
authors.affiliation: Respiratory Infectious Diseases Unit, National Institute for Infectious Diseases "L. Spallanzani," Rome.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Palmieri
authors.affiliation: National Referral Centre for Mycobacteria, Athens Chest Hospital, Ministry of Health, Greece.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Papavasileiou
authors.affiliation: Division of Infectious Diseases, CHU Saint-Pierre, Université Libre de Bruxelles, Belgium.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Payen
authors.affiliation: Clinical Epidemiology and Medical Statistics Unit, Department of Biomedical Sciences, University of Sassari, Research, Medical Education and Professional Development Unit, AOU Sassari.
authors.forename: Andrea
authors.initials: A
authors.lastname: Piana
authors.affiliation: Pneumology Unit, Fondazione S. Maugeri, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Clinical and Research Institute, Tradate Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Spanevello
authors.affiliation: National Hospital Hipólito Unanue, Public Health Institute, Ministry of Health, Lima, Perù
authors.forename: Dante
authors.initials: D
authors.lastname: Vargas Vasquez
authors.affiliation: AOVV E. Morelli Hospital, Reference Hospital for MDR and HIV-TB, Sondalo.
authors.forename: Pietro
authors.initials: P
authors.lastname: Viggiani
authors.affiliation: Department of Respiratory Medicine, Barts Health NHS Trust.
authors.forename: Veronica
authors.initials: V
authors.lastname: White
authors.affiliation: Division of Infection and Immunity, University College London and NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, United Kingdom.
authors.forename: Alimuddin
authors.initials: A
authors.lastname: Zumla
authors.affiliation: WHO Collaborating Centre for TB and Lung Diseases.
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Migliori
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D019818:Clavulanic Acid / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D054908:Extensively Drug-Resistant Tuberculosis / Q000188:drug therapy*; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000995:Antitubercular Agents; D019818:Clavulanic Acid; D015378:Imipenem