title: Synthesis and Biological Activities of Lanthanide (III) Nitrate Complexes with N-(2-hydroxynaphthalen-1-yl) methylene) Nicotinohydrazide Schiff Base.
abstract: BACKGROUND
  The field of coordination chemistry has registered a phenomenal growth during the last few decades. It is well known that precious metals have been used for medicinal purposes for at least 3500 years. At that time, precious metals were believed to benefit health because of their rarity, but research has now well established the link between medicinal properties of inorganic drugs and specific biological properties.
  
  
  METHODS
  The current study was designed to explain the synthesis and characterization of the lanthanide (III) nitrate complexes with N-(2-hydroxynaphthalen-1-yl) methylene) nicotinohydrazide schiff base and to evaluate the antibacterial and the antioxidant activities of the schiff base and it's lanthanide ion complexes. Antimicrobial activity of the Lanthanide (III) nitrate complexes with N-(2- hydroxynaphthalen-1-yl) methylene) nicotinohydrazide schiff base was estimated by minimum inhibitory concentration (MIC, µg/mL) using a micro-broth dilution method for different clinical isolates such as Eschereshia coli and Enterococcus faecalis. The antioxidant activities of the ligand and its lanthanide complexes were tested using a UV-Visible spectrophotometer by preparing 5x10-4M of all tested samples and DPPH in Dimethyl sulphoxide (DMSO).
  
  
  RESULTS
  Our present study has shown that moderate antimicrobial activity exists against both ligand and its complexes. There was no significant difference between Gram-positive and Gram-negative bacteria towards the tested ligand and its complexes. The free ligand has scavenging activity between 13-21 % while all complexes are more efficient in quenching DPPH than free ligand.
  
  
  CONCLUSIONS
  The results obtained herein indicate that the ligand and its complexes have a considerable antibacterial activity as well as antioxidant activity in quenching DPPH.
authors.affiliation: Department of Chemical Sciences, Faculty of Science and Arts, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.. Jordan.
authors.forename: Ahmed K
authors.initials: AK
authors.lastname: Hijazi
authors.forename: Ziyad A
authors.initials: ZA
authors.lastname: Taha
authors.forename: Abdulaziz M
authors.initials: AM
authors.lastname: Ajlouni
authors.forename: Waleed M
authors.initials: WM
authors.lastname: Al-Momani
authors.forename: Idris M
authors.initials: IM
authors.lastname: Idris
authors.forename: Eman A
authors.initials: EA
authors.lastname: Hamra
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D028581:Lanthanoid Series Elements / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009566:Nitrates / Q000737:chemistry / Q000494:pharmacology*; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D056831:Coordination Complexes; D028581:Lanthanoid Series Elements; C000622101:N-(2-hydroxynaphthalen-1-yl)methylene)nicotinohydrazide; D009566:Nitrates; D012545:Schiff Bases; D009536:Niacinamide
keywords: DPPH.; Hydrazone; MIC; antibacterial; antioxidant; lanthanides