title: A Study on the Quality and Identity of Brazilian Pampa Biome Honey: Evidences for Its Beneficial Effects against Oxidative Stress and Hyperglycemia.
abstract: We characterized, for the first time, the quality and identity of Brazilian Pampa biome honey and its antioxidant properties in vitro (FRAP, DDPH and ABTS). The potential protective effect of honey against oxidative stress induced by iron (Fe) and paraquat, (PQ) in a Drosophila melanogaster model (in vivo) was also tested. The results indicated that all honey samples tested showed antioxidant activity in vitro. Flies treated with honey showed increased lifespan and were protected against oxidative stress induced by Fe and PQ. Despite the high concentration of sugars in honey (approximately 70-80%), our results demonstrate a hypoglycemic-like effect of honey in Drosophila. Thus, this study demonstrates the high quality of Brazilian Pampa biome honey as well as its significant antioxidant activity in vitro and in vivo, pointing to the potential use of this natural product as an alternative in the therapy of oxidative stress-associated diseases.
authors.affiliation: Interdisciplinary Center for Biotechnology Research, CIPBIOTEC, Universidade Federal do Pampa, Campus São Gabriel, 97300-000 São Gabriel, RS, Brazil; Department of Chemistry, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
authors.forename: L C
authors.initials: LC
authors.lastname: Cruz
authors.affiliation: Department of Chemistry, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
authors.forename: J E S
authors.initials: JE
authors.lastname: Batista
authors.affiliation: Interdisciplinary Center for Biotechnology Research, CIPBIOTEC, Universidade Federal do Pampa, Campus São Gabriel, 97300-000 São Gabriel, RS, Brazil; Department of Chemistry, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
authors.forename: A P P
authors.initials: AP
authors.lastname: Zemolin
authors.affiliation: Department of Chemistry, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
authors.forename: M E M
authors.initials: ME
authors.lastname: Nunes
authors.affiliation: Department of Chemistry, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
authors.forename: D B
authors.initials: DB
authors.lastname: Lippert
authors.affiliation: Department of Chemistry, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
authors.forename: L F F
authors.initials: LF
authors.lastname: Royes
authors.affiliation: Department of Chemistry, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
authors.forename: F A
authors.initials: FA
authors.lastname: Soares
authors.affiliation: Interdisciplinary Center for Biotechnology Research, CIPBIOTEC, Universidade Federal do Pampa, Campus São Gabriel, 97300-000 São Gabriel, RS, Brazil.
authors.forename: A B
authors.initials: AB
authors.lastname: Pereira
authors.affiliation: Department of Chemistry, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
authors.forename: T
authors.initials: T
authors.lastname: Posser
authors.affiliation: Department of Chemistry, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
authors.forename: J L
authors.initials: JL
authors.lastname: Franco