title: Restless Legs Syndrome/Willis-Ekbom Disease and Periodic Limb Movements: A Comprehensive Review of Epidemiology, Pathophysiology, Diagnosis and Treatment Considerations.
abstract: Restless legs syndrome (RLS) or Willis-Ekbom Disease is a common, but frequently under- recognized and misdiagnosed condition seen in many subspecialty practices including neurology, sleep medicine, primary care and rheumatology. Periodic limb movements are a frequent co-morbid diagnosis in RLS. Despite prior beliefs that the condition was "benign", it has been demonstrated to have a considerable impact on sufferers quality of life, physically and psychologically, as well as socially. This chapter is meant as a comprehensive review of RLS encompassing epidemiology, pathophysiology, diagnosis, and treatment considerations.
authors.affiliation: Department of Neurology, Faculty of University of Illinois College of Medicine, Peoria, 100 NE Randolph Ave, Peoria, Illinois, USA.. dpbenoit@uic.edu.
authors.forename: Dyveke P
authors.initials: DP
authors.lastname: Pratt
mesh_terms: D006801:Humans; D020189:Nocturnal Myoclonus Syndrome; D012148:Restless Legs Syndrome