title: Amphiphilic block copolymers-based mixed micelles for noninvasive drug delivery.
abstract: Amphiphilic block copolymers-based mixed micelles established as new drug-loading system showed superior characteristics in delivering drug such as improved solubility, enhanced stability, multifunctional carrier materials, targeting ability, and high bioavailability. Recently, there are increasing focuses on exploration and study of noninvasive routes, and the results present perfect feasibility, improved compliance and fewer aches and pains. The aim to apply mixed micelles to noninvasive alternative routes has driven massive pharmaceutical attention. Recently, various studies of micelles strategy for noninvasive routes have been conducted to overcome the inherent barriers for uptake across the gastrointestinal tract, mucosal membranes and other in vivo noninvasive barriers, and the result argues well. The objective of this article is to summary these studies and developments of mixed micelles used on noninvasive drug delivery and provide a reference for further research.
authors.affiliation: a Department of Pharmacy , People's Hospital of Linzi District , Linzi , China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Xu
authors.affiliation: a Department of Pharmacy , People's Hospital of Linzi District , Linzi , China.
authors.forename: Peimin
authors.initials: P
authors.lastname: Yang
authors.affiliation: a Department of Pharmacy , People's Hospital of Linzi District , Linzi , China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Ma
authors.affiliation: a Department of Pharmacy , People's Hospital of Linzi District , Linzi , China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Yin
authors.affiliation: a Department of Pharmacy , People's Hospital of Linzi District , Linzi , China.
authors.forename: Xiangxia
authors.initials: X
authors.lastname: Wu
authors.affiliation: a Department of Pharmacy , People's Hospital of Linzi District , Linzi , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: a Department of Pharmacy , People's Hospital of Linzi District , Linzi , China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Xu
authors.affiliation: a Department of Pharmacy , People's Hospital of Linzi District , Linzi , China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
mesh_terms: D001682:Biological Availability; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D041981:Gastrointestinal Tract / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007413:Intestinal Mucosa / Q000378:metabolism; D008823:Micelles; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility
chemical_list: D004337:Drug Carriers; D008823:Micelles; D004364:Pharmaceutical Preparations; D011108:Polymers
keywords: Amphiphilic copolymers; anti-cancer drugs; mixed micelles; noninvasive routes