title: In Estimated Good Prognosis Patients Could Unexpected "Hyporesponse" to Controlled Ovarian Stimulation be Related to Genetic Polymorphisms of FSH Receptor?
abstract: It has been reported that 10% to 15% of young normogonadotrophic women show suboptimal response to standard gonadotropin-releasing hormone-a long protocol. These patients require higher doses of exogenous follicle-stimulating hormone (FSH). This phenomenon could be associated with genetic characteristics. In this study, FSH receptor polymorphism was retrospectively evaluated in 42 normoresponder young women undergoing an in vitro fertilization/intracytoplasmic sperm injection cycle; patients were stratified according to recombinant human FSH (r-hFSH) consumption. We selected 17 normoresponder young patients who required a cumulative dose of recombinant FSH (rFSH) >2500 UI (group A). A control group was randomly selected among patients who required a cumulative dose of rFSH <2500 UI (group B). Follicle-stimulating hormone receptor (FSH-R) 307Ala and 680Ser variants were analyzed in all our patients. Our results show that the mean number of rFSH vials (36.3 ± 7.5 vs 28.6 ± 4.5, P = .0001) and days of stimulation (12.7 ± 2.4 vs 10.8 ± 2.8, P = .03) were significantly lower in group B, whereas the number of oocytes retrieved (7.1 ± 1.5 vs 9.6 ± 2.4; P = .0005) and the average number of embryos transferred (2.1 ± 0.7 vs 2.7 ± 0.4; P = .001) were significantly lower in group A. Estradiol serum levels on the human chorionic gonadotrophin day were significantly lower in group A (997.8 ± 384.9 pg/mL vs 1749.1 ± 644.4; P = .0001). The incidence of the Ser/Ser genotype was higher in patients with higher r-hFSH consumption (group A; P = .02). Based on our results, we hypothesize an association between the FSH-R polymorphisms and a "hyporesponse" to exogenous FSH.
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology, University of Naples "Federico II," Naples, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Alviggi
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology, University of Naples "Federico II," Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Conforti
authors.affiliation: Outpatient Fertility Unit, Second University of Naples, Naples, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Caprio
authors.affiliation: Department of Woman and Child Health, University of Padua, Padua, Italy ginecologia_padova@libero.it.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gizzo
authors.affiliation: Department of Woman and Child Health, University of Padua, Padua, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Noventa
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology, University of Naples "Federico II," Naples, Italy.
authors.forename: Ida
authors.initials: I
authors.lastname: Strina
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology, University of Naples "Federico II," Naples, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Pagano
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology, University of Naples "Federico II," Naples, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: De Rosa
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology, University of Naples "Federico II," Naples, Italy.
authors.forename: Floriana
authors.initials: F
authors.lastname: Carbone
authors.affiliation: Outpatient Fertility Unit, Second University of Naples, Naples, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Colacurci
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology, University of Naples "Federico II," Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Placido
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D005838:Genotype; D006801:Humans; D010062:Ovulation Induction; D011110:Polymorphism, Genetic; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D011962:Receptors, FSH / Q000235:genetics*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
chemical_list: D011962:Receptors, FSH; D011994:Recombinant Proteins; D005640:Follicle Stimulating Hormone
keywords: FSH receptor; controlled ovarian stimulation; genetic mutation; in vitro fertilization; ovarian response; receptor polymorphism; recombinant FSH