title: Adjunctive Treatment in Juvenile Nasopharyngeal Angiofibroma: How Should We Approach Recurrence?
abstract: A recent case of advanced, recurrent juvenile nasopharyngeal angiofibroma (JNA) at our institution has highlighted the limited evidence regarding adjunctive treatment. We present the case of a 10-year-old boy who is the first to undergo multiple-staged surgical resections alongside vincristine treatment. We performed a review of the literature analyzing the roles of radiation therapy, cytotoxic drugs, and novel targeted agents in JNA relapse. Small cohort studies suggest radiotherapy and flutamide are the most rational treatment options for residual and recurrent JNA. Our review highlights the need for further research into the management of primary and recurrent JNA.
authors.affiliation: *ENT Department, Whipps Cross Hospital, London †Department of Pathology ‡ENT Department, Birmingham Children's Hospital §School of Cancer Sciences, University of Birmingham ∥Paediatric Oncology Department, Birmingham Children's Hospital, Birmingham, UK.
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Scholfield
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Brundler
authors.forename: Ann-Louise
authors.initials: AL
authors.lastname: McDermott
authors.forename: Francis
authors.initials: F
authors.lastname: Mussai
authors.forename: Pamela
authors.initials: P
authors.lastname: Kearns
mesh_terms: D018322:Angiofibroma / Q000473:pathology / Q000628:therapy*; D000970:Antineoplastic Agents / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant / Q000379:methods*; D002648:Child; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D057605:Natural Orifice Endoscopic Surgery; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D014750:Vincristine