title: Diet Quality Scores and Risk of Nasopharyngeal Carcinoma in Chinese Adults: A Case-Control Study.
abstract: Many studies show that dietary factors may affect the risk of nasopharyngeal carcinoma (NPC). We examined the association between overall diet quality and NPC risk in a Chinese population. This case-control study included 600 NPC patients and 600 matched controls between 2009 and 2011 in Guangzhou, China. Habitual dietary intake and various covariates were assessed via face-to-face interviews. Diet quality scores were calculated according to the Healthy Eating Index-2005 (HEI-2005), the alternate Healthy Eating Index (aHEI), the Diet Quality Index-International (DQI-I), and the alternate Mediterranean Diet Score (aMed). After adjustment for various lifestyle and dietary factors, greater diet quality scores on the HEI-2005, aHEI, and DQI-I-but not on the aMed-showed a significant association with a lower risk of NPC (p-trends, <0.001-0.001). The odds ratios (95% confidence interval) comparing the extreme quartiles of the three significant scores were 0.47 (0.32-0.68) (HEI-2005), 0.48 (0.33-0.70) (aHEI), and 0.43 (0.30-0.62) (DQI-I). In gender-stratified analyses, the favorable association remained significant in men but not in women. We found that adherence to the predefined dietary patterns represented by the HEI-2005, aHEI, and DQI-I scales predicted a lower risk of NPC in adults from south China, especially in men.
authors.affiliation: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. wangch28@mail2.sysu.edu.cn.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. Linxiaol@sysucc.org.cn.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Lin
authors.affiliation: Sun Yat-sen University Ophthalmic Center, Guangzhou 510060, China. Fanyy@sysucc.org.cn.
authors.forename: Yu-Ying
authors.initials: YY
authors.lastname: Fan
authors.affiliation: Information Section, Central Hospital of Panyu District, Guangzhou 511400, China. tingty@126.com.
authors.forename: Yuan-Ting
authors.initials: YT
authors.lastname: Liu
authors.affiliation: Department of Radiotherapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. Zhangxingl@sysucc.org.cn.
authors.forename: Xing-Lan
authors.initials: XL
authors.lastname: Zhang
authors.affiliation: Sun Yat-sen University Ophthalmic Center, Guangzhou 510060, China. luyunkai@mail.sysu.edu.cn.
authors.forename: Yun-Kai
authors.initials: YK
authors.lastname: Lu
authors.affiliation: Clinical laboratory section of the office outpatient Department public security board, Guangdong 510050, China. ladychun@126.com.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Xu
authors.affiliation: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. chenyum@mail.sysu.edu.cn.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Chen
mesh_terms: D000328:Adult; D002277:Carcinoma; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D004032:Diet / Q000009:adverse effects; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D015596:Nutrition Assessment; D009752:Nutritional Status; D016017:Odds Ratio; D065840:Protective Factors; D064167:Recommended Dietary Allowances; D012307:Risk Factors; D012737:Sex Factors
keywords: Chinese; adults; case-control study; diet quality; dietary pattern; nasopharyngeal carcinoma