title: Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China.
abstract: Genetic variants at KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 have been associated with type 2 diabetes mellitus (T2DM), but the results are contradictory in Chinese populations. The aim of the present study was to investigate the association of these four SNPs with T2DM in a large population of Han Chinese at Henan province, China. Seven-hundred-thirty-six patients with T2DM (cases) and Seven-hundred-sixty-eight healthy glucose-tolerant controls were genotyped for KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963. The association of genetic variants in these four genes with T2DM was analyzed using multivariate logistic regression. Genotypes and allele distributions of KCNQ1 rs151290 were significantly different between the cases and controls (p < 0.05). The AC and CC genotypes and the combined AC + CC genotype of rs151290 in KCNQ1 were associated with increases risk of T2DM before (OR = 1.482, 95% CI = 1.062-2.069; p = 0.021; OR = 1.544, 95% CI = 1.097-2.172, p = 0.013; and OR = 1.509, 95% CI = 1.097-2.077, p = 0.011, respectively) and after (OR = 1.539, 95% CI = 1.015-2.332, p = 0.042; OR = 1.641, 95% CI = 1.070-2.516, p = 0.023; and OR = 1.582, 95% CI = 1.061-2.358, p = 0.024; respectively) adjustment for sex, age, anthropometric measurements, biochemical indexes, smoking and alcohol consumption. Consistent with results of genotype analysis, the C allele of rs151290 in KCNQ1 was also associated with increased risk of T2DM (OR = 1.166, 95% CI = 1.004-1.355, p = 0.045). No associations between genetic variants of KLF14 rs972283, GCKR rs780094 or MTNR1B rs10830963 and T2DM were detected. The AC and CC genotypes and the C allele of rs151290 in KCNQ1 may be risk factors for T2DM in Han Chinese in Henan province.
authors.affiliation: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China. gao_kp@szu.edu.cn.
authors.forename: Kaiping
authors.initials: K
authors.lastname: Gao
authors.affiliation: Department of Traditional Chinese Medicine Prevention, Preventive Medicine Research Evaluation Center, Henan University of Traditional Chinese Medicine, Zhengzhou 450001, China. wangjinjin510@163.com.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China. lilinlin@zzu.edu.cn.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China. zhaiyujiamodi@163.com.
authors.forename: Yujia
authors.initials: Y
authors.lastname: Zhai
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China. ryc12@sina.com.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China. youhaifei1987@163.com.
authors.forename: Haifei
authors.initials: H
authors.lastname: You
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China. wangby95@163.com.
authors.forename: Bingyuan
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China. wxl@szu.edu.cn.
authors.forename: Xuli
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China. lijianna@szu.edu.cn.
authors.forename: Jianna
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China. daisysg@szu.edu.cn.
authors.forename: Zichen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China. lixiong1@email.szu.edu.cn.
authors.forename: Xiong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China. hyx413459261@sina.com.
authors.forename: Yaxin
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China. lxp2005@szu.edu.cn.
authors.forename: Xin-Ping
authors.initials: XP
authors.lastname: Luo
authors.affiliation: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China. hud@szu.edu.cn.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Hu
authors.affiliation: Division of Neurogenetics, Center for Neurological Diseases and Cancer, University Graduate School of Medicine, Nagoya 4668550, Japan. ohnok@med.nagoya-u.ac.jp.
authors.forename: Kinji
authors.initials: K
authors.lastname: Ohno
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China. tjwcj2005@126.com.
authors.forename: Chongjian
authors.initials: C
authors.lastname: Wang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000368:Aged; D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D051657:KCNQ1 Potassium Channel; D051741:Kruppel-Like Transcription Factors; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044123:Receptor, Melatonin, MT2; D051703:Sp Transcription Factors
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C485100:GCKR protein, human; D051657:KCNQ1 Potassium Channel; C496909:KCNQ1 protein, human; C417549:KLF14 protein, human; D051741:Kruppel-Like Transcription Factors; C573871:MTNR1B protein, human; D044123:Receptor, Melatonin, MT2; D051703:Sp Transcription Factors
keywords: KCNQ1; risk factors; single nucleotide polymorphism; type 2 diabetes