title: Kidney Biopsy: An Experience from Tertiary Hospital.
abstract: BACKGROUND
  Kidney Biopsy is an important diagnostic tool in Nephrology. It is useful in Nephrology in terms of diagnosis, prognosis and management. There is little information on renal biopsy data from central Nepal. We describe our center`s experience in kidney biopsy in term of histological patterns, complications and outcomes.
  
  
  METHODS
  We prospectively analyzed the biopsies data of patients over a period of one and half year. All kinds of kidney disease patients were included for kidney biopsy, irrespective of their clinical syndromes and underlying diagnosis.
  
  
  RESULTS
  A total of 75 biopsies were analyzed. Majority of them were females; 42 (56%). Most of the biopsies; 63 (84%) were from younger subjects ≤ 45 years and majority of them fell in the age group 11-20 years. Most common clinical renal syndrome to undergo biopsy was Sub Nephrotic range Proteinuria in 40 (53.3%). Among comorbid conditions, 40 (53.3%) had Hypertension. The most common histological pattern seen was Mesangial proliferative Glomerulonephritis seen in 18 (24%). Among complications associated with the procedure, macroscopic hematuria was seen in 5 (6.7%) cases and clinically significant perinephric hematoma causing pain was seen in 4 (5.3%). There was no mortality associated with biopsy procedure.
  
  
  CONCLUSIONS
  Sub Nephrotic range Proteinuria was the commonest clinical renal Syndrome observed. In terms of renal histology, Mesangial Proliferative Glomerulonephritis (MesPGN) was the commonest histological pattern observed. Kidney biopsy is a safe procedure without any significant adverse events.
authors.affiliation: Department of Nephrology, College of Medical Sciences Teaching Hospital, Bharatpur, Chitwan, Nepal.
authors.forename: Madhav
authors.initials: M
authors.lastname: Ghimire
authors.affiliation: Department of Nephrology, College of Medical Sciences Teaching Hospital, Bharatpur, Chitwan, Nepal.
authors.forename: Bishnu
authors.initials: B
authors.lastname: Pahari
authors.affiliation: Department of Nephrology, College of Medical Sciences Teaching Hospital, Bharatpur, Chitwan, Nepal.
authors.forename: Navaraj
authors.initials: N
authors.lastname: Paudel
authors.affiliation: Department of Nephrology, College of Medical Sciences Teaching Hospital, Bharatpur, Chitwan, Nepal.
authors.forename: Gayatri
authors.initials: G
authors.lastname: Das
authors.affiliation: Department of Nephrology, College of Medical Sciences Teaching Hospital, Bharatpur, Chitwan, Nepal.
authors.forename: Gopal Chandra
authors.initials: GC
authors.lastname: Das
authors.affiliation: Department of Cardiology, College of Medical Sciences Teaching Hospital, Bharatpur, Chitwan, Nepal.
authors.forename: Sanjib Kumar
authors.initials: SK
authors.lastname: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D015433:Glomerulonephritis, Membranous / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D006406:Hematoma / Q000209:etiology; D006417:Hematuria / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007037:Hypothyroidism / Q000453:epidemiology; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D008181:Lupus Nephritis / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009390:Nepal / Q000453:epidemiology; D009395:Nephritis, Interstitial / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D009402:Nephrosis, Lipoid / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D011446:Prospective Studies; D011507:Proteinuria / Q000209:etiology / Q000473:pathology*; D062606:Tertiary Care Centers; D055815:Young Adult
keywords: kidney biopsy; meningeal proliferative glomerulonephritis; sub nephrotic range proteinuria.