title: Porous poly(L-lactic acid) sheet prepared by stretching with starch particles as filler for tissue engineering.
abstract: Porous poly(L-lactic acid) (PLLA) sheets were prepared by uniaxial stretching PLLA sheets containing starch filler. Here, the starch filler content, stretching ratio, stretching rate and stretching temperature are important factors to influence the structure of the porous PLLA sheets, therefore, they have been investigated in detail. The pore size distribution and tortuosity were characterized by Mercury Intrusion Porosimetry. The results revealed that the porosity and pore size enlarged with the increase of the starch filler content and stretching ratio, while shrank with the rise of stretching temperature. On the other hand, the pore structure almost had no changes with the stretching rate ranging between 5 and 40 mm/min. In order to test and verify that the porous PLLA sheet was suitable for the tissue engineering, the starch particles were removed by selective enzymatic degradation and its in vitro biocompatibility to osteoblast-like MC3T3-E1 cells was investigated.
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 10080, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Ju
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: ljhan@ciac.ac.cn.
authors.forename: Lijing
authors.initials: L
authors.lastname: Han
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 10080, China.
authors.forename: Zonglin
authors.initials: Z
authors.lastname: Li
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 10080, China.
authors.forename: Yunjing
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Harbin Welding Institute, China Academy of Machinery Science & Technology, Harbin 150028, China.
authors.forename: Qingjiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Junjia
authors.initials: J
authors.lastname: Bian
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: dongls@ciac.ac.cn.
authors.forename: Lisong
authors.initials: L
authors.lastname: Dong
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002460:Cell Line; D051379:Mice; D010006:Osteoblasts / Q000166:cytology; D011091:Polyesters / Q000737:chemistry*; D016062:Porosity; D013213:Starch / Q000737:chemistry*; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide); D013213:Starch
keywords: Cell adhesion; Poly(l-lactic acid); Porous structure; Starch particles; Stretching