title: Assessment of cholecystokinin 2 receptor (CCK2R) in neoplastic tissue.
abstract: The expression of cholecystokinin 2 receptor (CCK2R, CCKBR or gastrin receptor) has been reported on a diverse range of cancers such as colorectal, liver, lung, pancreatic, ovarian, stomach, thyroid and numerous neuroendocrine/carcinoid tumors. Some cancers of the colorectum, lung, pancreas and thyroid have been shown to overexpress CCK2R in relation to normal matched tissues of the same organ. This reported overexpression has led to the development of a number of CCK2R-ligand targeted imaging and therapeutic agents. However, no comprehensive study comparing the expression of CCK2R in multiple cancers to multiple normal tissues has been performed. Herein, we report the immunohistochemical analysis of cancer samples from gastrointestinal stromal tumor (GIST), hepatocellular carcinoma (HCC), non-small cell lung cancer (NSCLC), pancreatic adenocarcinoma, and thyroid cancer against multiple normal tissue samples from esophagus, liver, lung, pancreas, stomach, spleen and thyroid. These results show that CCK2R expression is present in nearly all cancer and normal samples tested and that none of the cancer samples had expression that was statistically greater than that of all of the normal samples.
authors.affiliation: Center for Drug Discovery, Purdue University, West Lafayette, IN 47907 USA.|Department of Chemistry, Purdue University, West Lafayette, IN 47907 USA.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Roy
authors.affiliation: Center for Drug Discovery, Purdue University, West Lafayette, IN 47907 USA.
authors.forename: Karson S
authors.initials: KS
authors.lastname: Putt
authors.affiliation: Department of Anatomic Pathology, H. Lee Moffitt Cancer Center, Tampa, FL 33612 USA.
authors.forename: Domenico
authors.initials: D
authors.lastname: Coppola
authors.affiliation: Department of Anatomic Pathology, H. Lee Moffitt Cancer Center, Tampa, FL 33612 USA.
authors.forename: Marino E
authors.initials: ME
authors.lastname: Leon
authors.affiliation: Department of Anatomic Pathology, H. Lee Moffitt Cancer Center, Tampa, FL 33612 USA.
authors.forename: Farah K
authors.initials: FK
authors.lastname: Khalil
authors.affiliation: Department of Anatomic Pathology, H. Lee Moffitt Cancer Center, Tampa, FL 33612 USA.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Centeno
authors.affiliation: Tissue Core, H. Lee Moffitt Cancer Center, Tampa, FL 33612 USA.
authors.forename: Noel
authors.initials: N
authors.lastname: Clark
authors.affiliation: Department of Cancer Imaging and Metabolism, Imaging and Technology Center of Excellence, H. Lee Moffitt Cancer Center, Tampa, FL 33612 USA.
authors.forename: Valerie E
authors.initials: VE
authors.lastname: Stark
authors.affiliation: Department of Cancer Imaging and Metabolism, Imaging and Technology Center of Excellence, H. Lee Moffitt Cancer Center, Tampa, FL 33612 USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Morse
authors.affiliation: Center for Drug Discovery, Purdue University, West Lafayette, IN 47907 USA.|Department of Chemistry, Purdue University, West Lafayette, IN 47907 USA.
authors.forename: Philip S
authors.initials: PS
authors.lastname: Low
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D046152:Gastrointestinal Stromal Tumors / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000378:metabolism / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D043887:Receptor, Cholecystokinin B / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D043887:Receptor, Cholecystokinin B
keywords: CCK2R; CCKBR; cholecystokinin 2 receptor; gastrin receptor