title: Fish Reveal Origins of Melanoma.
abstract: A new study of zebrafish may explain why only certain skin cells grow into tumors. Besides melanoma-promoting mutations, these cells express key neural crest genes, such as crestin and sox10, that induce regression to an embryonic state. They also bear epigenetic changes that might amplify expression of these genes.
authors.forename: Mitch
authors.initials: M
authors.lastname: Leslie
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D006801:Humans; D008545:Melanoma / Q000209:etiology*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D015027:Zebrafish
chemical_list: D016159:Tumor Suppressor Protein p53; D048493:Proto-Oncogene Proteins B-raf