title: Invasive Mechanical Ventilation and Mortality in Pediatric Hematopoietic Stem Cell Transplantation: A Multicenter Study.
abstract: OBJECTIVE
  To establish the current respiratory practice patterns in pediatric hematopoietic stem cell transplant patients and investigate their associations with mortality across multiple centers.
  
  
  METHODS
  Retrospective cohort between 2009 and 2014.
  
  
  METHODS
  Twelve children's hospitals in the United States.
  
  
  METHODS
  Two hundred twenty-two pediatric allogeneic hematopoietic stem cell transplant recipients with acute respiratory failure using invasive mechanical ventilation.
  
  
  METHODS
  None.
  
  
  RESULTS
  PICU mortality of our cohort was 60.4%. Mortality at 180 days post PICU discharge was 74%. Length of PICU stay prior to initiation of invasive mechanical ventilation was significantly lower in survivors, and the odds of mortality increased for longer length of PICU stay prior to intubation. A total of 91 patients (41%) received noninvasive ventilation at some point during their PICU stay prior to intubation. Noninvasive ventilation use preintubation was associated with increased mortality (odds ratio, 2.1; 95% CI, 1.2-3.6; p = 0.010). Patients ventilated longer than 15 days had higher odds of death (odds ratio, 2.4; 95% CI, 1.3-4.2; p = 0.004). Almost 40% of patients (n = 85) were placed on high-frequency oscillatory ventilation with a mortality of 76.5% (odds ratio, 3.3; 95% CI, 1.7-6.5; p = 0.0004). Of the 20 patients who survived high-frequency oscillatory ventilation, 18 were placed on high-frequency oscillatory ventilation no later than the third day of invasive mechanical ventilation. In this subset of 85 patients, transition to high-frequency oscillatory ventilation within 2 days of the start of invasive mechanical ventilation resulted in a 76% decrease in the odds of death compared with those who transitioned to high-frequency oscillatory ventilation later in the invasive mechanical ventilation course.
  
  
  CONCLUSIONS
  This study suggests that perhaps earlier more aggressive critical care interventions in the pediatric hematopoietic stem cell transplant patient with respiratory failure requiring invasive mechanical ventilation may offer an opportunity to improve outcomes.
authors.affiliation: 1Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN. 2Department of Pediatrics, Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, NJ. 3Department of Pediatrics, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI. 4Department of Anesthesia, Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 5Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MN. 6Department of Pediatrics, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY. 7Department of Pediatrics, Dana-Farber Cancer Institute, Boston, MA. 8Department of Pediatrics, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY. 9Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA. 10Department of Pediatrics, Duke Children's Hospital, Durham, NC. 11Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH. 12Department of Pediatrics, Pennsylvania State University College of Medicine, Penn State Hershey Children's Hospital, Hershey, PA. 13Department of Public Health, Pennsylvania State University College of Medicine, Penn State Hershey Children's Hospital, Hershey, PA.
authors.forename: Courtney M
authors.initials: CM
authors.lastname: Rowan
authors.forename: Shira J
authors.initials: SJ
authors.lastname: Gertz
authors.forename: Jennifer
authors.initials: J
authors.lastname: McArthur
authors.forename: Julie C
authors.initials: JC
authors.lastname: Fitzgerald
authors.forename: Mara E
authors.initials: ME
authors.lastname: Nitu
authors.forename: Ashley
authors.initials: A
authors.lastname: Loomis
authors.forename: Deyin D
authors.initials: DD
authors.lastname: Hsing
authors.forename: Christine N
authors.initials: CN
authors.lastname: Duncan
authors.forename: Kris M
authors.initials: KM
authors.lastname: Mahadeo
authors.forename: Lincoln S
authors.initials: LS
authors.lastname: Smith
authors.forename: Jerelyn
authors.initials: J
authors.lastname: Moffet
authors.forename: Mark W
authors.initials: MW
authors.lastname: Hall
authors.forename: Emily L
authors.initials: EL
authors.lastname: Pinos
authors.forename: Ira M
authors.initials: IM
authors.lastname: Cheifetz
authors.forename: Robert F
authors.initials: RF
authors.lastname: Tamburro
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002985:Clinical Protocols; D003422:Critical Care; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D007442:Intubation, Intratracheal / Q000009:adverse effects; D007902:Length of Stay; D008297:Male; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods*; D012131:Respiratory Insufficiency / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies