title: Comparison of two different drug-coated balloons for the treatment of in-stent restenosis: A long-term single-centre experience.
abstract: OBJECTIVE
  We aim to evaluate the long-term efficacy of two different paclitaxel-coated balloons (PCBs) for the treatment of coronary in-stent restenosis (ISR).
  
  
  METHODS
  Between February 2011 and February 2012, all consecutive patients with ISR lesions treated with the SeQuent® Please (B. Braun, Melsungen, Germany) PCB or with the DIOR® (Eurocor GmbH, Bonn, Germany) PCB at our institution were prospectively included and followed up for 36months by clinical observation. The primary endpoint was the clinically driven target lesion revascularization (TLR) rate at 36months.
  
  
  RESULTS
  65 patients with 74 ISR lesions were included. 43 ISR lesions were treated with the SeQuent® Please PCB and 31 with the DIOR® PCB. Baseline clinical, lesion characteristics and procedural data did not significantly differ between the groups. The TLR rate was significantly lower in patients treated with the SeQuent® Please PCB compared with the DIOR® PCB (4.7% vs. 22. 6%, p=0.03) at 36months.
  
  
  CONCLUSIONS
  This registry suggests that there are differences in terms of TLR between two clinically available PCBs. The SeQuent® Please PCB demonstrated lower TLR rate compared to the DIOR® PCB at 36months follow up.
authors.affiliation: Department of Cardiology,Hospital de Jerez de la Frontera,Jerez de la Frontera,Cádiz,Spain. Electronic address: javbenezet@hotmail.com.
authors.forename: Javier
authors.initials: J
authors.lastname: Benezet
authors.affiliation: Department of Cardiology,Hospital de Jerez de la Frontera,Jerez de la Frontera,Cádiz,Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Agarrado
authors.affiliation: Department of Cardiology,Hospital de Jerez de la Frontera,Jerez de la Frontera,Cádiz,Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gutiérrez-Barrios
authors.affiliation: Department of Cardiology,Hospital de Jerez de la Frontera,Jerez de la Frontera,Cádiz,Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Ruiz-Fernandez
authors.affiliation: Department of Cardiology,Hospital de Jerez de la Frontera,Jerez de la Frontera,Cádiz,Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Del Río
authors.affiliation: Department of Cardiology,Hospital de Jerez de la Frontera,Jerez de la Frontera,Cádiz,Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Cañadas
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation*; D062906:Cardiac Catheters; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D020099:Coated Materials, Biocompatible; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation*; D011446:Prospective Studies; D012042:Registries; D013030:Spain; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D020099:Coated Materials, Biocompatible
keywords: Angioplasty; Drug-coated balloons; In stent restenosis; Target lesion revascularization