title: Mechanisms of interleukin-22's beneficial effects in acute pancreatitis.
abstract: Acute pancreatitis (AP) is a disorder characterized by parenchymal injury of the pancreas controlled by immune cell-mediated inflammation. AP remains a significant challenge in the clinic due to a lack of specific and effective treatment. Knowledge of the complex mechanisms that regulate the inflammatory response in AP is needed for the development of new approaches to treatment, since immune cell-derived inflammatory cytokines have been recognized to play critical roles in the pathogenesis of the disease. Recent studies have shown that interleukin (IL)-22, a cytokine secreted by leukocytes, when applied in the severe animal models of AP, protects against the inflammation-mediated acinar injury. In contrast, in a mild AP model, endogenous IL-22 has been found to be a predominantly anti-inflammatory mediator that inhibits inflammatory cell infiltration via the induction of Reg3 proteins in acinar cells, but does not protect against acinar injury in the early stage of AP. However, constitutively over-expressed IL-22 can prevent the initial acinar injury caused by excessive autophagy through the induction of the anti-autophagic proteins Bcl-2 and Bcl-XL. Thus IL-22 plays different roles in AP depending on the severity of the AP model. This review focuses on these recently reported findings for the purpose of better understanding IL-22's regulatory roles in AP which could help to develop a novel therapeutic strategy.
authors.affiliation: Chongmin Huan, Daniel Kim, Antonio Alfonso, Albert Stanek, Department of Surgery, Downstate Medical Center, State University of New York, Brooklyn, NY 11203, United States.
authors.forename: Chongmin
authors.initials: C
authors.lastname: Huan
authors.affiliation: Chongmin Huan, Daniel Kim, Antonio Alfonso, Albert Stanek, Department of Surgery, Downstate Medical Center, State University of New York, Brooklyn, NY 11203, United States.
authors.forename: Daniel
authors.initials: D
authors.lastname: Kim
authors.affiliation: Chongmin Huan, Daniel Kim, Antonio Alfonso, Albert Stanek, Department of Surgery, Downstate Medical Center, State University of New York, Brooklyn, NY 11203, United States.
authors.forename: Peiqi
authors.initials: P
authors.lastname: Ou
authors.affiliation: Chongmin Huan, Daniel Kim, Antonio Alfonso, Albert Stanek, Department of Surgery, Downstate Medical Center, State University of New York, Brooklyn, NY 11203, United States.
authors.forename: Antonio
authors.initials: A
authors.lastname: Alfonso
authors.affiliation: Chongmin Huan, Daniel Kim, Antonio Alfonso, Albert Stanek, Department of Surgery, Downstate Medical Center, State University of New York, Brooklyn, NY 11203, United States.
authors.forename: Albert
authors.initials: A
authors.lastname: Stanek
keywords: Acinar cell; Acute pancreatitis; Cytokine; Inflammatory response; Interleukin-22