title: Influence of rapid- and slow-rate resorption collagen membrane in maxillary sinus augmentation.
abstract: OBJECTIVE
  To evaluate the effects of low- and rapid-resorption-rate bioabsorbable collagen membranes in maxillary sinus augmentation procedure in rabbits considering Schneiderian membrane (SM) reaction and bone tissue formation.
  
  
  METHODS
  Eighteen male adult rabbits underwent bilateral maxillary sinus augmentation with particulate bovine hydroxyapatite to be divided into three groups, as follows: Group C - control, no membrane; Group RR - rapid resorbable collagen membrane; and Group SR - slow-resorbable collagen membrane. The animals were euthanized after 30 and 120 days for specimen's removal to be prepared and analyzed under light microscopy, histomorphometry, and immunohistochemistry for Runx2 and VEGF labeling.
  
  
  RESULTS
  Histopathology evaluation presented similar healing pattern among the groups with a satisfactory response of SM, both at day 30 and day 120. Bone histomorphometry did not reveal significant differences among the groups, as well as immunohistochemistry analysis, which presented intense immunolabeling for both proteins in all groups.
  
  
  CONCLUSIONS
  The presence of both membranes did not negatively interfere in bone formation and remodeling, and the focal mild inflammatory reaction caused by their degrading process did not impair the reconstructive procedure.
authors.affiliation: Oral Biology Master's Program, Sagrado Coração University, USC, Bauru, Brazil.
authors.forename: Marco Dapievi
authors.initials: MD
authors.lastname: Bresaola
authors.affiliation: Department of Basic Sciences, State of São Paulo University - FOA/UNESP, Araçatuba, Brazil.|Oral Biology Doctoral's Program, Sagrado Coração University, USC, Araçatuba, Brazil.
authors.forename: Mariza Akemi
authors.initials: MA
authors.lastname: Matsumoto
authors.affiliation: Oral Biology Master's Program, Sagrado Coração University, USC, Bauru, Brazil.
authors.forename: Abbas
authors.initials: A
authors.lastname: Zahoui
authors.affiliation: Oral Biology Doctoral's Program, Bauru School of Dentistry, University of São Paulo - FOB/USP, Bauru, Brazil.
authors.forename: Claudia Cristina
authors.initials: CC
authors.lastname: Biguetti
authors.affiliation: Oral Biology Master's and Doctoral's Program, Department of Oral Maxillofacial Surgery, Sagrado Coração University, USC, Bauru, Brazil.
authors.forename: Hugo
authors.initials: H
authors.lastname: Nary-Filho
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D016723:Bone Remodeling / Q000502:physiology; D018786:Bone Substitutes; D002417:Cattle; D003094:Collagen; D017886:Durapatite; D008297:Male; D008443:Maxillary Sinus / Q000473:pathology / Q000601:surgery*; D023421:Models, Animal; D009297:Nasal Mucosa; D010012:Osteogenesis / Q000502:physiology*; D011817:Rabbits; D059546:Sinus Floor Augmentation / Q000379:methods*
chemical_list: D018786:Bone Substitutes; D003094:Collagen; D017886:Durapatite
keywords: biomaterials; sinus floor elevation; wound healing