title: Beyond the Fold: Emerging Biological Applications of DNA Origami.
abstract: The use of DNA as a material for nanoscale construction has blossomed in the past decade. This is largely attributable to the DNA origami technique, which has enabled construction of nanostructures ranging from simple two-dimensional sheets to complex three-dimensional objects with defined curves and edges. These structures are amenable to site-specific functionalization with nanometer precision, and have been shown to exhibit cellular biocompatibility and permeability. The DNA origami technique has already found widespread use in a variety of emerging biological applications such as biosensing, enzyme cascades, biomolecular analysis, biomimetics, and drug delivery. We highlight a few of these applications and comments on the prospects for this rapidly expanding field of research.
authors.affiliation: The RNA Institute, University at Albany, State University of New York, Albany, NY, 12222, USA. arunrichard@nyu.edu.
authors.forename: Arun Richard
authors.identifier: 0000-0001-6757-5464
authors.initials: AR
authors.lastname: Chandrasekaran
authors.affiliation: Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.|Center for Biotechnology and Interdisciplinary Studies (CBIS), Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
authors.forename: Nate
authors.initials: N
authors.lastname: Anderson
authors.affiliation: Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.|Center for Biotechnology and Interdisciplinary Studies (CBIS), Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
authors.forename: Megan
authors.initials: M
authors.lastname: Kizer
authors.affiliation: The RNA Institute, University at Albany, State University of New York, Albany, NY, 12222, USA.
authors.forename: Ken
authors.initials: K
authors.lastname: Halvorsen
authors.affiliation: Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA. wangx28@rpi.edu, wangx28@rpi.edu.|Center for Biotechnology and Interdisciplinary Studies (CBIS), Rensselaer Polytechnic Institute, Troy, NY, 12180, USA. wangx28@rpi.edu, wangx28@rpi.edu.
authors.forename: Xing
authors.initials: X
authors.lastname: Wang
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000378:metabolism; D032701:Biomimetics; D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D011506:Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D052157:Aptamers, Nucleotide; D004337:Drug Carriers; D011506:Proteins; D004247:DNA
keywords: DNA origami; DNA structures; G-Quadruplexes; designer DNA; nanotechnology