title: Cross-reactivity between avian influenza A (H7N9) virus and divergent H7 subtypic- and heterosubtypic influenza A viruses.
abstract: The number of human avian H7N9 influenza infections has been increasing in China. Understanding their antigenic and serologic relationships is crucial for developing diagnostic tools and vaccines. Here, we evaluated the cross-reactivities and neutralizing activities among H7 subtype influenza viruses and between H7N9 and heterosubtype influenza A viruses. We found strong cross-reactivities between H7N9 and divergent H7 subtypic viruses, including H7N2, H7N3, and H7N7. Antisera against H7N2, H7N3, and H7N7 could also effectively neutralize two distinct H7N9 strains. Two-way cross-reactivities exist within group 2, including H3 and H4, whereas one-way cross-reactivities were found across other groups, including H1, H10, H9, and H13. Our data indicate that the hemaglutinins from divergent H7 subtypes may facilitate the development of vaccines for distinct H7N9 infections. Moreover, serologic diagnoses for H7N9 infections need to consider possible interference from the cross-reactivity of H7N9 with other subtype influenza viruses.
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) &Peking Union Medical College, Beijing, P. R. China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Guo
authors.affiliation: Institute of Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, P. R.China.
authors.forename: Dayan
authors.initials: D
authors.lastname: Wang
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) &Peking Union Medical College, Beijing, P. R. China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Zhou
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) &Peking Union Medical College, Beijing, P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wu
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) &Peking Union Medical College, Beijing, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) &Peking Union Medical College, Beijing, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) &Peking Union Medical College, Beijing, P. R. China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, P. R. China.
authors.forename: Lili
authors.initials: L
authors.lastname: Ren
authors.affiliation: Fondation Mérieux, IRF 128 BioSciences Lyon-Gerland, 69365 Lyon, France.
authors.forename: Gláucia
authors.initials: G
authors.lastname: Paranhos-Baccalà
authors.affiliation: Institute of Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, P. R.China.
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Shu
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) &Peking Union Medical College, Beijing, P. R. China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Jin
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) &Peking Union Medical College, Beijing, P. R. China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, P. R. China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D001717:Birds / Q000276:immunology / Q000821:virology; D056738:Cross Protection; D003429:Cross Reactions; D004285:Dogs; D006389:Hemagglutinins, Viral / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000737:chemistry*; D057917:Influenza A Virus, H7N2 Subtype / Q000737:chemistry / Q000145:classification / Q000276:immunology; D057920:Influenza A Virus, H7N3 Subtype / Q000737:chemistry / Q000145:classification / Q000276:immunology; D053126:Influenza A Virus, H7N7 Subtype / Q000737:chemistry / Q000145:classification / Q000276:immunology; D064766:Influenza A Virus, H7N9 Subtype / Q000737:chemistry / Q000145:classification / Q000276:immunology; D007252:Influenza Vaccines / Q000096:biosynthesis; D005585:Influenza in Birds / Q000097:blood / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D007251:Influenza, Human / Q000097:blood / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D061985:Madin Darby Canine Kidney Cells; D010802:Phylogeny
chemical_list: D000914:Antibodies, Viral; D006389:Hemagglutinins, Viral; D007106:Immune Sera; D007252:Influenza Vaccines