title: Transforming growth factor-β1 induces cholesterol synthesis by increasing HMG-CoA reductase mRNA expression in keratinocytes.
abstract: In this study, we investigated the effect of TGF-β1 on cholesterol synthesis in human keratinocytes. TGF-β1 increased the level of cholesterol and the mRNA level of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in human keratinocytes. These results show that TGF-β1 induces cholesterol synthesis by increasing HMG-CoA reductase mRNA expression in human keratinocytes.
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Yamane
authors.affiliation: b Faculty of Applied Bioscience, Department of Nutritional Science , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Aimi
authors.initials: A
authors.lastname: Muramatsu
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Shimura
authors.affiliation: b Faculty of Applied Bioscience, Department of Nutritional Science , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kobayashi-Hattori
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oishi
mesh_terms: D000214:Acyl Coenzyme A / Q000096:biosynthesis*; D002460:Cell Line; D002784:Cholesterol / Q000819:agonists / Q000096:biosynthesis*; D015870:Gene Expression; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics* / Q000378:metabolism; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D012333:RNA, Messenger / Q000819:agonists / Q000235:genetics* / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000494:pharmacology*
chemical_list: D000214:Acyl Coenzyme A; D012333:RNA, Messenger; D053773:Transforming Growth Factor beta1; C008047:3-hydroxy-3-methylglutaryl-coenzyme A; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases
keywords: 3-hydroxy-3-methylglutaryl coenzyme A reductase; cholesterol; keratinocyte; transforming growth factor-β1