title: Improved Cardiovascular Disease Outcomes in Older Adults.
abstract: Longevity is increasing and the population of older adults is growing. The biology of aging is conducive to cardiovascular disease (CVD), such that prevalence of coronary artery disease, heart failure, valvular heart disease, arrhythmia and other disorders are increasing as more adults survive into old age.  Furthermore, CVD in older adults is distinctive, with management issues predictably complicated by multimorbidity, polypharmacy, frailty and other complexities of care that increase management risks (e.g., bleeding, falls, and rehospitalization) and uncertainty of outcomes.  In this review, state-of-the-art advances in heart failure, acute coronary syndromes, transcatheter aortic valve replacement, atrial fibrillation, amyloidosis, and CVD prevention are discussed.  Conceptual benefits of treatments are considered in relation to the challenges and ambiguities inherent in their application to older patients.
authors.affiliation: Geriatric Cardiology Section, University of Pittsburgh Medical Center, Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Forman
authors.affiliation: Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Alexander
authors.affiliation: Philip R. Lee Institute for Health Policy Studies, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Ralph G
authors.initials: RG
authors.lastname: Brindis
authors.affiliation: Department of Medicine, University at Buffalo, Buffalo, New York, USA.
authors.forename: Anne B
authors.initials: AB
authors.lastname: Curtis
authors.affiliation: Department of Medicine, Columbia University Medical Center, New York, USA.
authors.forename: Mathew
authors.initials: M
authors.lastname: Maurer
authors.affiliation: Washington University School of Medicine, St Louis, MO, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Rich
authors.affiliation: Emory University School of Medicine and Rollins School of Public Health, Emory University, Atlanta, GA, USA.
authors.forename: Laurence
authors.initials: L
authors.lastname: Sperling
authors.affiliation: Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA, USA.
authors.forename: Nanette K
authors.initials: NK
authors.lastname: Wenger
keywords: Cardiovascular; Geriatric; HFpEF