title: The Prevalence of Peyronie's Disease in the United States: A Population-Based Study.
abstract: Peyronie's disease (PD) is a connective tissue disorder which can result in penile deformity. The prevalence of diagnosed PD in the United States (US) has been estimated to be 0.5% in adult males, but there is limited additional information comparing definitive and probable PD cases. We conducted a population-based survey to assess PD prevalence using a convenience-sample of adult men participating in the ResearchNow general population panel. Respondents were categorized according to PD status (definitive, probable, no PD) and segmented by US geographic region, education, and income levels. Of the 7,711 respondents, 57 (0.7%) had definitive PD while 850 (11.0%) had probable PD. Using univariate logistic regression modeling, older age (18-24 vs 24+) (OR = 0.721; 95% CI = 0.570,0.913), Midwest/Northeast/West geographic region (South vs Midwest/Northeast/West) (OR = 0.747; 95% CI = 0.646,0.864), and higher income level (<25K vs 25K+) (OR = 0.820; 95% CI = 0.673,0.997) were each significantly associated with reduced odds of having a definitive/probable PD diagnosis compared with no PD diagnosis. When all three variables were entered in a stepwise multivariable logistic regression, only age (OR = 0.642; 95% CI = 0.497, 0.828) and region (OR = 0.752; 95% CI = 0.647, 0.872) remained significant. This study is the first to report PD prevalence by geographic region and income, and it advocates that the prevalence of PD in the US may be higher than previously cited. Further, given the large discrepancy between definitive PD cases diagnosed by a physician and probable cases not diagnosed by a physician, much more needs to be done to raise awareness of this disease.
authors.affiliation: Deerfield Institute, New York, New York, United States of America.
authors.forename: Mark
authors.initials: M
authors.lastname: Stuntz
authors.affiliation: Deerfield Institute, New York, New York, United States of America.
authors.forename: Anna
authors.initials: A
authors.lastname: Perlaky
authors.affiliation: Formerly at Deerfield Institute, New York, New York, United States of America.
authors.forename: Franka
authors.initials: F
authors.lastname: des Vignes
authors.affiliation: Yale Center for Analytical Services, Yale School of Public Health, New Haven, Connecticut, United States of America.
authors.forename: Tassos
authors.initials: T
authors.lastname: Kyriakides
authors.affiliation: Deerfield Institute, New York, New York, United States of America.
authors.forename: Dan
authors.initials: D
authors.lastname: Glass
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D005843:Geography; D006801:Humans; D007182:Income; D020407:Internet; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D015995:Prevalence; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology; D055815:Young Adult