title: Nickel-Catalyzed Negishi Cross-Coupling of Bromodifluoroacetamides.
abstract: A nickel-catalyzed Negishi coupling of bromodifluoroacetamides with arylzinc reagents has been developed. This reaction allows access to difluoromethylated aromatic compounds containing a variety of aryl groups and amide moieties. Furthermore, highly effective transformation of the functionalized difluoromethyl group (-CF2CONR(1)R(2)) was realized via microwave-assisted reduction under mild conditions. The notable features of this strategy are its generality and its use of a low-cost nickel catalyst and ligand; thus, this reaction provides a facile method for applications in drug discovery and development.
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University , 45-1 Nagaotogecho, Hirakata, Osaka 573-0101, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tarui
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University , 45-1 Nagaotogecho, Hirakata, Osaka 573-0101, Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Shinohara
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University , 45-1 Nagaotogecho, Hirakata, Osaka 573-0101, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sato
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University , 45-1 Nagaotogecho, Hirakata, Osaka 573-0101, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Omote
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University , 45-1 Nagaotogecho, Hirakata, Osaka 573-0101, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ando