title: The Complimentary Role of Methoxy-Isobutyl-Isonitrile and Hand-Held Gamma Probe in Adamantinoma.
abstract: Adamantinoma is a rare locally aggressive osteolytic tumor that is found 90% of the time in the diaphysis of the tibia with the remaining lesions found in the fibula and long tubular bones. A case of adamantinoma of the tibia is presented. The added value of nuclear medicine investigations in the workup of this patient is described. A three-phase whole body (99m)Tc-methylene diphosphonate bone and a whole body (99m)Tc-methoxy-isobutyl-isonitrile scans were complimentary in the demarcation of viable bone tumor and the assessment of the remainder of the bone and soft tissue to exclude other sites. Intra-operative assistance with a hand-held gamma probe, guided the biopsy of the most metabolically active tumor tissue. Histology revealed a biphasic tumor composed of epithelial and fibrous components, in keeping with an adamantinoma.
authors.affiliation: Department of Nuclear Medicine, Umhlanga Molecular Imaging and Therapy, Centre of Excellence, Umhlanga, South Africa.
authors.forename: Masha
authors.initials: M
authors.lastname: Maharaj
authors.affiliation: Department of Medical Imaging and Clinical Oncology, Stellenbosch University, and Tygerberg Hospital, South Africa.
authors.forename: Nisaar
authors.initials: N
authors.lastname: Korowlay
authors.affiliation: Department of Medical Imaging and Clinical Oncology, Stellenbosch University, and Tygerberg Hospital, South Africa.
authors.forename: Prof
authors.initials: P
authors.lastname: Ellmann
keywords: Adamantinoma; bone scan; gamma probe; methoxy-isobutyl-isonitrile; tumor