title: Hypervalent Iodine-Induced Oxidative Couplings (New Metal-Free Coupling Advances and Their Applications in Natural Product Syntheses).
abstract: Recently, hypervalent iodine reagents have been extensively used in organic synthesis. A variety of reactions available for natural product syntheses have been developed using phenyliodine(III) diacetate (PIDA), phenyliodine(III) bis(trifluoroacetate) (PIFA), and other iodine(III) and (V) reagents. These reactions are expected to have applications in pharmaceutical and agrochemical processes because of their safety, mild reaction conditions, and high yields of pure products. Under such considerations, this chapter focuses on the oxidative coupling reactions of hypervalent iodine reagents found in total syntheses of biologically active natural products and their related compounds.
authors.affiliation: College of Pharmaceutical Science, Ritsumeikan University, 1-1-1 Nojihigasshi, Kusatsu, Shiga, 525-8577, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Dohi
authors.affiliation: College of Pharmaceutical Science, Ritsumeikan University, 1-1-1 Nojihigasshi, Kusatsu, Shiga, 525-8577, Japan. kita@ph.ritsumei.ac.jp.|Research Organization of Science and Technology, Ritsumeikan University, 1-1-1 Nojihigasshi, Kusatsu, Shiga, 525-8577, Japan. kita@ph.ritsumei.ac.jp.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kita
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis*; D007462:Iodobenzenes / Q000737:chemistry*; D058451:Oxidative Coupling; D014269:Trifluoroacetic Acid / Q000737:chemistry*
chemical_list: D001688:Biological Products; D007462:Iodobenzenes; C517666:phenyliodine(III) bis(trifluoroacetate); D014269:Trifluoroacetic Acid
keywords: Hypervalent iodine reagents; Natural products; Oxidative coupling; Total synthesis