title: Glycosylated Notch and Cancer.
abstract: Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the addition of sugar moieties, such as O-fucose, O-glucose, or O-xylose, to bring about structural and functional changes. Disruption to glycosylation processes of Notch proteins result in developmental disorders and disease, including cancer. This review summarizes the importance and recent updates on the role of glycosylated Notch proteins in tumorigenesis and tumor metastasis.
authors.affiliation: Department of Biology, University of Western Ontario , London, ON , Canada.
authors.forename: Shanmugasundaram
authors.initials: S
authors.lastname: Pakkiriswami
authors.affiliation: School of Life Sciences, Queen's Medical Centre, University of Nottingham , Nottingham , UK.
authors.forename: Africa
authors.initials: A
authors.lastname: Couto
authors.affiliation: School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK; School of Chemical and Biotechnology, Shanmugha Arts, Science, Technology & Research Academy, Thanjavur, India.
authors.forename: Usha
authors.initials: U
authors.lastname: Nagarajan
authors.affiliation: School of Life Sciences, Queen's Medical Centre, University of Nottingham , Nottingham , UK.
authors.forename: Marios
authors.initials: M
authors.lastname: Georgiou
keywords: Notch signaling; epidermal growth factor; glycosyltransferases; tumorigenesis