title: Bariatric Surgery Outcomes in Sarcopenic Obesity.
abstract: Sarcopenic obesity is the combination of low muscle mass and strength with increased fat mass. This condition is associated with negative health outcomes. We hypothesized that sarcopenia could be a pejorative factor on surgical weight loss.
  
  
  
  The objectives of the study are to determine the influence of sarcopenic obesity on gastric bypass and sleeve gastrectomy results regarding weight loss and comorbidities resolution at 3, 6, and 12 months.
  
  
  
  The study was conducted at the University Hospital.
  
  
  
  Sixty-nine obese patients who benefited from bariatric surgery were included. Skeletal muscle mass was determined by the Janssen's equation. Physical performance and muscle strength were determined using the 6-min walk test and the wall sit test. Obese subjects from the lowest tertile of the Skeletal Muscle mass Index (SMI) of Baumgartner were set as sarcopenic.
  
  
  
  Weight loss outcomes and rate of weight loss failure were not influenced by sarcopenia. At 1 year, mean EBMIL% was 75.4 % ± 5 in sarcopenic subjects vs 67.8 % ±4 in the non-sarcopenic subjects (p = 0.242). Improvement rates of co-morbidities were similar between groups. Skeletal muscle mass was no more different between groups at 1 year after surgery. There was no patient lost to follow-up.
  
  
  
  Bariatric surgery remains effective in achieving weight loss target in sarcopenic patients, with similar remission rates of main comorbidities and similar safety profile than in the non-sarcopenic group. Whether bariatric surgery could result in improvement or deterioration of daily living activities disabilities and functional autonomy in sarcopenic obese patients still have to be evaluated.
authors.affiliation: Department of Endocrinology and Metabolic disease, Institute of Internal Medicine, University of Cagliari, Monserrato, 09045, Cagliari, Italy.|Department of Endocrinology Diabetology and Nutrition, Groupement Hospitalier Lyon Sud, Hospices Civils de Lyon, F69495, Pierre Bénite, France.
authors.forename: Diego
authors.initials: D
authors.lastname: Mastino
authors.affiliation: Department of Digestive Surgery, Center of Bariatric Surgery, Hopital Edouard Herriot, Hospices Civils de Lyon, F69437, Lyon, France.|Fédération Hospitalo-Universitaire DO-IT. Centre Intégré et Spécialisé de L'Obésité de Lyon. CRNH-RA, Hospices Civils de Lyon, Lyon, France.|University Claude Bernard Lyon 1, Lyon, France.
authors.forename: Maud
authors.initials: M
authors.lastname: Robert
authors.affiliation: Department of Endocrinology Diabetology and Nutrition, Groupement Hospitalier Lyon Sud, Hospices Civils de Lyon, F69495, Pierre Bénite, France.|Fédération Hospitalo-Universitaire DO-IT. Centre Intégré et Spécialisé de L'Obésité de Lyon. CRNH-RA, Hospices Civils de Lyon, Lyon, France.|University Claude Bernard Lyon 1, Lyon, France.
authors.forename: Cecile
authors.initials: C
authors.lastname: Betry
authors.affiliation: Department of Endocrinology Diabetology and Nutrition, Groupement Hospitalier Lyon Sud, Hospices Civils de Lyon, F69495, Pierre Bénite, France.|Fédération Hospitalo-Universitaire DO-IT. Centre Intégré et Spécialisé de L'Obésité de Lyon. CRNH-RA, Hospices Civils de Lyon, Lyon, France.|University Claude Bernard Lyon 1, Lyon, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Laville
authors.affiliation: Department of Digestive Surgery, Center of Bariatric Surgery, Hopital Edouard Herriot, Hospices Civils de Lyon, F69437, Lyon, France.|Fédération Hospitalo-Universitaire DO-IT. Centre Intégré et Spécialisé de L'Obésité de Lyon. CRNH-RA, Hospices Civils de Lyon, Lyon, France.|University Claude Bernard Lyon 1, Lyon, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Gouillat
authors.affiliation: Department of Endocrinology Diabetology and Nutrition, Groupement Hospitalier Lyon Sud, Hospices Civils de Lyon, F69495, Pierre Bénite, France. emmanuel.disse@gmail.com.|Fédération Hospitalo-Universitaire DO-IT. Centre Intégré et Spécialisé de L'Obésité de Lyon. CRNH-RA, Hospices Civils de Lyon, Lyon, France. emmanuel.disse@gmail.com.|University Claude Bernard Lyon 1, Lyon, France. emmanuel.disse@gmail.com.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Disse
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D015897:Comorbidity; D005260:Female; D005743:Gastrectomy; D015390:Gastric Bypass; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D018482:Muscle, Skeletal; D009765:Obesity / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D055948:Sarcopenia / Q000150:complications* / Q000503:physiopathology; D015431:Weight Loss
keywords: Bariatric surgery; Morbid obesity; Muscle mass; Sarcopenia; Weight loss outcomes