title: Evaluating the use of Floseal haemostatic matrix in the treatment of epistaxis: a prospective, control-matched longitudinal study.
abstract: Epistaxis is a common cause of emergency admissions in ENT. The use of Floseal haemostatic matrix in the treatment of epistaxis has been investigated in a number of studies in North America. We aimed to report a UK-based experience in the context of the current UK management paradigm. The study was designed as a prospective, unrandomised, control-matched longitudinal study. Cases were matched to controls in order to reduce the risk of bias. The overall treatment success rate for Floseal was 75 %, similar to the rates reported by studies based in North America. Nasal packing carried a success rate of 85 % and there was no statistically significant difference between the success rates of both treatments. Anecdotally Floseal can also be used successfully in thrombocyctopenic patients. There was a trend towards a shorter length of stay in the Floseal group, but this was not statistically significant. The 7-day readmission rate was 10 % for both the groups. This controlled study demonstrates that Floseal has a similar treatment success rate to nasal packing and that there may be a trend towards a shorter length of stay.
authors.affiliation: Department of ENT and Head and Neck Surgery, Aintree University Hospital NHS Foundation Trust, Liverpool, L9 7AL, UK. andrew.lau@liverpool.ac.uk.
authors.forename: Andrew S
authors.identifier: http://orcid.org/0000-0002-6489-204X
authors.initials: AS
authors.lastname: Lau
authors.affiliation: Department of ENT and Head and Neck Surgery, Aintree University Hospital NHS Foundation Trust, Liverpool, L9 7AL, UK.
authors.forename: Navdeep S
authors.initials: NS
authors.lastname: Upile
authors.affiliation: Department of ENT and Head and Neck Surgery, Aintree University Hospital NHS Foundation Trust, Liverpool, L9 7AL, UK.
authors.forename: Lepa
authors.initials: L
authors.lastname: Lazarova
authors.affiliation: Department of ENT and Head and Neck Surgery, Aintree University Hospital NHS Foundation Trust, Liverpool, L9 7AL, UK.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Swift
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D019468:Disease Management; D004844:Epistaxis / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005781:Gelatin Sponge, Absorbable / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008137:Longitudinal Studies; D008297:Male; D010359:Patient Readmission / Q000706:statistics & numerical data; D010865:Pilot Projects; D011446:Prospective Studies; D016896:Treatment Outcome; D006113:United Kingdom
chemical_list: C411004:FloSeal Matrix; D006490:Hemostatics
keywords: Epistaxis; Floseal matrix; Hemostasis; Length of stay; Thrombin