title: New Insights into the Role of Autophagy in Ovarian Cryopreservation by Vitrification.
abstract: Ovarian cryopreservation by vitrification is a highly useful method for preserving female fertility during radiotherapy and chemotherapy. However, cryoinjury, osmotic stress during vitrification, and ischemia/reperfusion during transplantation lead to loss of ovarian follicles. Ovarian follicle loss may be partially reduced by several methods; however, studies regarding the mechanism of ovarian follicle loss have only investigated cell apoptosis, which consists of type I programmed cell death. Autophagy is type II programmed cell death, and cell homeostasis is maintained by autophagy during conditions of stress. The role of autophagy during cryopreservation by vitrification has rarely been reported. The potential role of autophagy during ovarian cryopreservation by vitrification is reviewed in this article.
authors.affiliation: Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China alnord820119@163.com.
authors.forename: Yanzhou
authors.initials: Y
authors.lastname: Yang
authors.affiliation: The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
authors.forename: Hoi Hung
authors.initials: HH
authors.lastname: Cheung
authors.affiliation: The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
authors.forename: Wai Nok
authors.initials: WN
authors.lastname: Law
authors.affiliation: College of Life Science, Capital Normal University, Beijing, People's Republic of China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
authors.forename: Wai Yee
authors.initials: WY
authors.lastname: Chan
authors.affiliation: Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China peixiuying@163.com.
authors.forename: Xiuying
authors.initials: X
authors.lastname: Pei
authors.affiliation: Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China 4084304@163.com.
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001343:Autophagy; D015925:Cryopreservation; D005260:Female; D006801:Humans; D010053:Ovary / Q000637:transplantation; D058989:Vitrification
keywords: apoptosis,; atresia,; autophagy; cryobiology,; cryoinjury; cryopreservation,; ischemia/reperfusion; osmotic stress; ovarian cryopreservation; ovarian follicle death; ovarian transplantation; ovary