title: Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections.
abstract: The interindividual and intraindividual variabilities in daptomycin pharmacokinetics were investigated in 23 patients (69 pharmacokinetic profiles) who were treated for several months for bone and joint infections. Population daptomycin clearance was significantly influenced by renal function and was significantly higher in male than in female patients. We observed significant intraindividual changes in daptomycin clearance, which were uncorrelated with changes in renal function, suggesting that therapeutic drug monitoring is important in patients receiving prolonged daptomycin therapy.
authors.affiliation: Hospices Civils de Lyon, Groupement Hospitalier de Gériatrie, Service Pharmaceutique, Lyon, France ISPB, Faculté de Pharmacie de Lyon, Université Lyon 1, Lyon, France UMR CNRS 5558, Laboratoire de Biométrie et Biologie Evolutive, Université Lyon 1, Villeurbanne, France sylvain.goutelle@chu-lyon.fr.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Goutelle
authors.affiliation: Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Roux
authors.affiliation: Hospices Civils de Lyon, Groupement Hospitalier Edouard Herriot, Laboratoire de Biochimie et Biologie Moléculaire, UF de Pharmacologie Spécialisée, Lyon, France.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Gagnieu
authors.affiliation: Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Valour
authors.affiliation: Claude Bernard Lyon 1 University, Lyon, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lustig
authors.affiliation: Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France Claude Bernard Lyon 1 University, Lyon, France International Centre for Research in Infectiology, CIRI, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Ader
authors.affiliation: ISPB, Faculté de Pharmacie de Lyon, Université Lyon 1, Lyon, France Claude Bernard Lyon 1 University, Lyon, France International Centre for Research in Infectiology, CIRI, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Laurent
authors.affiliation: Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France Claude Bernard Lyon 1 University, Lyon, France International Centre for Research in Infectiology, CIRI, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Chidiac
authors.affiliation: Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France Claude Bernard Lyon 1 University, Lyon, France International Centre for Research in Infectiology, CIRI, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France.
authors.forename: Tristan
authors.initials: T
authors.lastname: Ferry
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001170:Arthritis, Infectious / Q000188:drug therapy*; D017576:Daptomycin / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin