title: Preparation of functionalized cotton fabrics by means of melatonin loaded β-cyclodextrin nanosponges.
abstract: Biofunctional textiles are a new category of advanced materials which combine conventional textiles with advanced drug delivery systems to obtain fabrics able to release active principles through skin. The work presents the synthesis of hyper cross-linked β-cyclodextrins nanosponges with the carbonyl group acting as bridge between cyclodextrin molecules. The result of the synthesis is a 3-D porous structure, where melatonin molecules have been complexed. The complex has been characterized by elemental analysis, DSC, SEM, XRD and FT-IR spectroscopy and the results confirm that melatonin interacts with the synthesized nanosponge at molecular level. Melatonin loaded nanosponges have been dispersed on cotton fibres, which have proved to be a suitable substrate for durable nanosponge adsorption. The in vitro release tests from the funtionalized fabrics have shown a zero order kinetics, which is typical of a reservoir diffusion controlled system.
authors.affiliation: Politecnico di Torino - Department of Applied Science and Technology, C.so Duca degli Abruzzi 24, Torino 10129, Italy. Electronic address: manuela.mihailiasa@gmail.com.
authors.forename: Manuela
authors.initials: M
authors.lastname: Mihailiasa
authors.affiliation: Università di Torino - Department of Chemistry, Via Pietro Giuria 7, Torino 10125, Italy. Electronic address: fabrizio.caldera@unito.it.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Caldera
authors.affiliation: Politecnico di Torino - Department of Applied Science and Technology, C.so Duca degli Abruzzi 24, Torino 10129, Italy. Electronic address: jiemeng.li@studenti.polito.it.
authors.forename: Jiemeng
authors.initials: J
authors.lastname: Li
authors.affiliation: Politecnico di Torino - Department of Applied Science and Technology, C.so Duca degli Abruzzi 24, Torino 10129, Italy. Electronic address: roberta.peila@polito.it.
authors.forename: Roberta
authors.initials: R
authors.lastname: Peila
authors.affiliation: Politecnico di Torino - Department of Applied Science and Technology, C.so Duca degli Abruzzi 24, Torino 10129, Italy. Electronic address: ada.ferri@polito.it.
authors.forename: Ada
authors.initials: A
authors.lastname: Ferri
authors.affiliation: Università di Torino - Department of Chemistry, Via Pietro Giuria 7, Torino 10125, Italy. Electronic address: francesco.trotta@unito.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Trotta
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D032561:Cotton Fiber / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D008550:Melatonin / Q000008:administration & dosage* / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D047392:beta-Cyclodextrins; D008550:Melatonin
keywords: 1-1′-Carbonyldiimidazole (PubChem CID: 68263); Cellulose fabrics; Elemental analysis; Melatonin; Melatonin (PubChem CID: 896); N,N-dimethylformamide (PubChem CID: 6228); XRD; β-Cyclodextrin (PubChem CID: 24238); β-Cyclodextrin nanosponges