title: Mitigation of paracetamol-induced reproductive damage by chrysin in male rats via reducing oxidative stress.
abstract: Paracetamol (PRC) is a nonsteroidal anti-inflammatory drug used widely as a painkiller for various diseases and as the symptomatic flu cure in several countries worldwide. PRC toxicity may occur under conditions of the overdose usage. Chrysin (CR) is a flavonoid that is naturally present in several plants, honey and propolis. The aim of this study was to investigate the effects of CR (at the doses of 25 mg kg-1and 50 mg kg-1) pre-treatment over seven consecutive days against PRC-induced reproductive toxicity in male rats. Our results showed that PRC toxicity decreased the sperm motility, and increased dead sperm rate, abnormal sperm cell rate, apoptosis and MDA levels in testicular tissues. Pre-treatment with CR at the dose of 25 and 50 mg kg-1for 7 days mitigated side effects of acute PRC toxicity in male reproductive system proportionally in a dose-dependent manner. This possible protection mechanism might be dependent on the antioxidant activity of CR. In conclusion, pre-treatment with CR at the dose of 25 and 50 mg kg-1for 7 days can be the beneficial against PRC-induced reproductive toxicity proportionally in a dose-dependent manner.
authors.affiliation: Department of Reproduction and Artificial Insemination, Veterinary Medicine Faculty, Atatürk University, Erzurum, Turkey.
authors.forename: E H
authors.initials: EH
authors.lastname: Aksu
authors.affiliation: Department of Pathology, Veterinary Medicine Faculty, Atatürk University, Erzurum, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Özkaraca
authors.affiliation: Department of Biochemistry, Veterinary Medicine Faculty, Atatürk University, Erzurum, Turkey.
authors.forename: F M
authors.initials: FM
authors.lastname: Kandemir
authors.affiliation: Department of Reproduction and Artificial Insemination, Veterinary Medicine Faculty, Atatürk University, Erzurum, Turkey.
authors.forename: A D
authors.initials: AD
authors.lastname: Ömür
authors.affiliation: Department of Biochemistry, Veterinary Medicine Faculty, Atatürk University, Erzurum, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Eldutar
authors.affiliation: Department of Biochemistry, Veterinary Medicine Faculty, Atatürk University, Erzurum, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Küçükler
authors.affiliation: Department of Pathology, Veterinary Medicine Faculty, Atatürk University, Erzurum, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Çomaklı
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism; D013737:Testis / Q000187:drug effects* / Q000378:metabolism
chemical_list: D018712:Analgesics, Non-Narcotic; D005419:Flavonoids; D000082:Acetaminophen; C043561:chrysin; D008315:Malondialdehyde
keywords: Bax/Bcl-2; caspase-3; male rat; paracetamol; sperm