title: Last Advances in Silicon-Based Optical Biosensors.
abstract: We review the most important achievements published in the last five years in the field of silicon-based optical biosensors. We focus specially on label-free optical biosensors and their implementation into lab-on-a-chip platforms, with an emphasis on developments demonstrating the capability of the devices for real bioanalytical applications. We report on novel transducers and materials, improvements of existing transducers, new and improved biofunctionalization procedures as well as the prospects for near future commercialization of these technologies.
authors.affiliation: Nanobiosensors and Bioanalytical Applications Group. Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, The Barcelona Institute of Science and Technology and CIBER-BBN, Campus UAB, Ed-ICN2, 08193 Bellaterra, Barcelona, Spain. adrian.fernandez@cin2.es.
authors.forename: Adrián
authors.initials: A
authors.lastname: Fernández Gavela
authors.affiliation: Nanobiosensors and Bioanalytical Applications Group. Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, The Barcelona Institute of Science and Technology and CIBER-BBN, Campus UAB, Ed-ICN2, 08193 Bellaterra, Barcelona, Spain. daniel.grajales@cin2.es.
authors.forename: Daniel
authors.initials: D
authors.lastname: Grajales García
authors.affiliation: School of Electrical and Computer Engineering (FEEC), University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil. jcordoba@decom.fee.unicamp.br.
authors.forename: Jhonattan C
authors.initials: JC
authors.lastname: Ramirez
authors.affiliation: Nanobiosensors and Bioanalytical Applications Group. Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, The Barcelona Institute of Science and Technology and CIBER-BBN, Campus UAB, Ed-ICN2, 08193 Bellaterra, Barcelona, Spain. laura.lechuga@cin2.es.|School of Electrical and Computer Engineering (FEEC), University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil. laura.lechuga@cin2.es.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Lechuga
keywords: label-free detection; photonic biosensors; silicon photonics; waveguide devices