title: [Anti DIC therapy].
abstract: A variety of disorders erratically activate coagulation cascades. The disseminated intravascular coagulation (DIC) is caused by unbalanced activation between coagulation and fibrinolysis. Some of auxiliary treatments for DIC on top of main therapy against causative disease are beneficial in terms of better outcome. The anticoagulation therapy is indicated when an activation of coagulation dominates in DIC caused by sepsis. Whereas in DIC associated with trauma, since balance between coagulation and fibrinolysis collapses drastically in a short period, both anticoagulantion therapy and antifibrinolytic therapy can be utilized depending on clinical conditions. There are quite a few of anti DIC agents in Japan. It is imperative to choose appropriate agents to treat DIC taking their pharmacological properties into account.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Yahata
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Sakamoto
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D000991:Antithrombins / Q000627:therapeutic use; D001550:Benzamidines; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D016670:Gabexate / Q000627:therapeutic use; D006146:Guanidines / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D011480:Protease Inhibitors / Q000627:therapeutic use; D011994:Recombinant Proteins; D018805:Sepsis / Q000150:complications; D018746:Systemic Inflammatory Response Syndrome / Q000150:complications; D018180:Thrombomodulin / Q000627:therapeutic use; D014148:Tranexamic Acid / Q000627:therapeutic use; D014947:Wounds and Injuries / Q000150:complications
chemical_list: D000925:Anticoagulants; D000933:Antifibrinolytic Agents; D000991:Antithrombins; D001550:Benzamidines; D006146:Guanidines; D011480:Protease Inhibitors; D011994:Recombinant Proteins; D018180:Thrombomodulin; D016670:Gabexate; D014148:Tranexamic Acid; D006493:Heparin; C032855:nafamostat