title: Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice.
abstract: A role of gut-brain axis emerges in the pathophysiology of anorexia nervosa and maintaining adapted physical activity during refeeding remains discussed. We aimed to assess gastrointestinal protein metabolism and investigate the contribution of physical activity during refeeding in C57BL/6 mice with activity-based anorexia (ABA). ABA mice exhibited lower body weight and food intake with increase of lean mass/fat mass ratio and fat oxidation. Colonic permeability was increased in ABA. Ad libitum food access was then restored and ABA group was divided into two subgroups, with access to running wheel (ABA-PA) or not (ABA-NPA). After refeeding, fat free mass was completely restored only in ABA-PA. Colonic permeability was enhanced in ABA-NPA. Finally, muscle kynurenine conversion into kynurenic acid was lower in ABA-NPA who also exhibited altered behavior. Maintaining physical activity during refeeding may thus limit colonic hyperpermeability and improve behavior in anorectic mice.
authors.affiliation: Normandie Univ, INSERM Unit 1073, UR, France.|Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.|Rouen University Hospital, Nutrition unit, Rouen, France.
authors.forename: Najate
authors.initials: N
authors.lastname: Achamrah
authors.affiliation: Normandie Univ, INSERM Unit 1073, UR, France.|Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Nobis
authors.affiliation: Normandie Univ, INSERM Unit 1073, UR, France.|Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Breton
authors.affiliation: Normandie Univ, INSERM Unit 1073, UR, France.|Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Jésus
authors.affiliation: Normandie Univ, INSERM Unit 1073, UR, France.|Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.|Rouen University Hospital, Nutrition unit, Rouen, France.
authors.forename: Liliana
authors.initials: L
authors.lastname: Belmonte
authors.affiliation: Rouen University Hospital, Laboratory of Medical Biochemistry, Rouen, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Maurer
authors.affiliation: Normandie Univ, INSERM Unit 1073, UR, France.|Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Legrand
authors.affiliation: Normandie Univ, INSERM Unit 1073, UR, France.|Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Bôle-Feysot
authors.affiliation: Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.|Animal Behavior Platform SCAC, University of Rouen, France.
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: do Rego
authors.affiliation: Normandie Univ, INSERM Unit 1073, UR, France.|Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Goichon
authors.affiliation: Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.|Animal Behavior Platform SCAC, University of Rouen, France.
authors.forename: Jean Claude do
authors.initials: JC
authors.lastname: Rego
authors.affiliation: Normandie Univ, INSERM Unit 1073, UR, France.|Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.|Rouen University Hospital, Nutrition unit, Rouen, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Déchelotte
authors.affiliation: Normandie Univ, INSERM Unit 1073, UR, France.|Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.
authors.forename: Sergueï O
authors.initials: SO
authors.lastname: Fetissov
authors.affiliation: Normandie Univ, INSERM Unit 1073, UR, France.|Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.|Rouen University Hospital, Laboratory of Medical Biochemistry, Rouen, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Claeyssens
authors.affiliation: Normandie Univ, INSERM Unit 1073, UR, France.|Institute for Research and Innovation in Biomedicine (IRIB), University of Rouen, France.|Rouen University Hospital, Nutrition unit, Rouen, France.
authors.forename: Moïse
authors.initials: M
authors.lastname: Coëffier
mesh_terms: D000818:Animals; D000856:Anorexia Nervosa / Q000503:physiopathology*; D001522:Behavior, Animal / Q000502:physiology*; D015153:Blotting, Western; D001823:Body Composition; D001835:Body Weight; D003106:Colon / Q000378:metabolism*; D004195:Disease Models, Animal; D004435:Eating; D004734:Energy Metabolism; D007737:Kynurenine / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000378:metabolism; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism; D047494:PPAR delta / Q000235:genetics / Q000378:metabolism; D010539:Permeability; D010805:Physical Conditioning, Animal; D012333:RNA, Messenger / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D062725:Tight Junction Proteins / Q000378:metabolism; D000637:Transaminases / Q000235:genetics / Q000378:metabolism
chemical_list: D047493:PPAR alpha; D047494:PPAR delta; D012333:RNA, Messenger; D062725:Tight Junction Proteins; D007737:Kynurenine; D000637:Transaminases; C021481:kynurenine-oxoglutarate transaminase