title: Influence of Mycotoxin Binders on the Oral Bioavailability of Doxycycline in Pigs.
abstract: Mycotoxin binders are feed additives that aim to adsorb mycotoxins in the gastrointestinal tract of animals, making them unavailable for systemic absorption. The antimicrobial drug doxycycline (DOX) is often used in pigs and is administered through feed or drinking water; hence, DOX can come in contact with mycotoxin binders in the gastrointestinal tract. This paper describes the effect of four mycotoxin binders on the absorption of orally administered DOX in pigs. Two experiments were conducted: The first used a setup with bolus administration to fasted pigs at two different dosages of mycotoxin binder. In the second experiment, DOX and the binders were mixed in the feed at dosages recommended by the manufacturers (= field conditions). Interactions are possible between some of the mycotoxin binders dosed at 10 g/kg feed but not at 2 g/kg feed. When applying field conditions, no influences were seen on the plasma concentrations of DOX.
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University , Salisburylaan 133, B-9820 Merelbeke, Belgium.
authors.forename: Thomas
authors.initials: T
authors.lastname: De Mil
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University , Salisburylaan 133, B-9820 Merelbeke, Belgium.
authors.forename: Mathias
authors.initials: M
authors.lastname: Devreese
authors.affiliation: Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University , Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
authors.forename: Sarah
authors.initials: S
authors.lastname: De Saeger
authors.affiliation: Department of Applied Biosciences, Faculty of Bioscience Engineering, Ghent University , Valentin Vaerwyckweg 1, B-9000 Ghent, Belgium.
authors.forename: Mia
authors.initials: M
authors.lastname: Eeckhout
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University , Salisburylaan 133, B-9820 Merelbeke, Belgium.
authors.forename: Patrick
authors.initials: P
authors.lastname: De Backer
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University , Salisburylaan 133, B-9820 Merelbeke, Belgium.
authors.forename: Siska
authors.initials: S
authors.lastname: Croubels
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D004318:Doxycycline / Q000493:pharmacokinetics*; D005503:Food Additives / Q000737:chemistry / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000378:metabolism; D009183:Mycotoxins / Q000378:metabolism; D013552:Swine / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D005503:Food Additives; D009183:Mycotoxins; D004318:Doxycycline
keywords: doxycycline; interactions; mycotoxin binder; pharmacokinetics; pigs