title: Evaluation of SCUBE-1 and sCD40L biomarkers in patients with hypothyroidism due to Hashimoto's thyroiditis: a single-blind, controlled clinical study.
abstract: OBJECTIVE
  This study was performed to investigate the levels of platelet activation marker SCUBE-1 and sCD40L which plays some role in the progression of atherosclerosis, in patients with hypothyroidism due to Hashimoto's thyroiditis.
  
  
  METHODS
  The cohort of this study includes 90 patients and 35 healthy volunteers, who admitted to the internal medicine out-patient. Simultaneously in the same samples; SCUBE-1 and sCD40L measurements were accomplished by enzyme-linked immunosorbent assay (ELISA). The data obtained were analyzed statistically.
  
  
  RESULTS
  Hypothyroidism due to Hashimoto's thyroiditis in comparison to the control group that includes healthy volunteers; SCUBE-1 and sCD40L, were increased. And these results were statistically significant (p < 0.05).
  
  
  CONCLUSIONS
  SCUBE-1 and sCD40L levels were increased in Hashimoto's hypothyroidism patients. This may indicate an increased endothelial dysfunction, platelet activation and cardiovascular risk in hypothyroidism. SCUBE-1 and sCD40L may be helpful in cardiovascular risk assessment of hypothyroid patients.
authors.affiliation: Department of Internal Medicine, Namik Kemal University School of Medicine, Tekirdag, Turkey. bulentbilir@yahoo.com.
authors.forename: B
authors.initials: B
authors.lastname: Bilir
authors.forename: N
authors.initials: N
authors.lastname: Soysal-Atile
authors.forename: B
authors.initials: B
authors.lastname: Ekiz Bilir
authors.forename: I
authors.initials: I
authors.lastname: Yilmaz
authors.forename: I
authors.initials: I
authors.lastname: Bali
authors.forename: N
authors.initials: N
authors.lastname: Altintas
authors.forename: D
authors.initials: D
authors.lastname: Baykiz
authors.forename: M
authors.initials: M
authors.lastname: Aydin
authors.forename: S
authors.initials: S
authors.lastname: Guldiken
mesh_terms: D015415:Biomarkers / Q000097:blood; D023201:CD40 Ligand / Q000097:blood*; D002135:Calcium-Binding Proteins; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D050031:Hashimoto Disease / Q000097:blood / Q000150:complications; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000209:etiology; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D012307:Risk Factors; D016037:Single-Blind Method
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D008565:Membrane Proteins; C469998:SCUBE1 protein, human; D023201:CD40 Ligand