title: Adjuvant role of radiation therapy for locally advanced laryngeal cancer without pathological lymph node metastasis.
abstract: Conclusion The application of adjuvant RT to reduce recurrence should be tailored in cases of pathologically negative node metastasis. Objectives The treatment modality following surgical resection of advanced laryngeal cancer is determined by adverse factors. Aside from lymph node metastasis (LNM) or positive margins, definite risk factors supporting adjuvant radiation therapy (RT) have not been clearly suggested. The aim of this study was to analyze the risk factors for advanced laryngeal cancer without LNM and the role of RT. Materials and methods Pathologically T3 and T4-staged laryngeal squamous cell carcinoma without LNM were reviewed. The patients were classified into RT (+) (n = 22) and RT (-) (n = 38) groups. Results Five-year overall survival (OS) of the RT (+) and RT (-) groups was 84.4% and 83.8%, respectively. Five-year disease-specific survival of the RT (+) and RT (-) groups was 88.4% and 93.9%. Five-year local control rate of the RT (+) and RT (-) groups was 94.7% and 91.3%. The factors affecting OS were smoking history and recurrence history (p = 0.02). By multivariate analysis, smoking history and recurrence history were determining factors for 5-year OS (p = 0.024 and p = 0.047, respectively).
authors.affiliation: a Department of Otolaryngology, Asan Medical Center , University of Ulsan College of Medicine , Seoul , Republic of Korea ;
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Kim
authors.affiliation: a Department of Otolaryngology, Asan Medical Center , University of Ulsan College of Medicine , Seoul , Republic of Korea ;
authors.forename: Yoon Se
authors.initials: YS
authors.lastname: Lee
authors.affiliation: a Department of Otolaryngology, Asan Medical Center , University of Ulsan College of Medicine , Seoul , Republic of Korea ;
authors.forename: Minsu
authors.initials: M
authors.lastname: Kwon
authors.affiliation: a Department of Otolaryngology, Asan Medical Center , University of Ulsan College of Medicine , Seoul , Republic of Korea ;
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: a Department of Otolaryngology, Asan Medical Center , University of Ulsan College of Medicine , Seoul , Republic of Korea ;
authors.forename: Jong-Lyel
authors.initials: JL
authors.lastname: Roh
authors.affiliation: a Department of Otolaryngology, Asan Medical Center , University of Ulsan College of Medicine , Seoul , Republic of Korea ;
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Choi
authors.affiliation: a Department of Otolaryngology, Asan Medical Center , University of Ulsan College of Medicine , Seoul , Republic of Korea ;
authors.forename: Sang Yoon
authors.initials: SY
authors.lastname: Kim
authors.affiliation: b Department of Radiation Oncology, Asan Medical Center , University of Ulsan College of Medicine , Seoul , Republic of Korea.
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Lee
authors.affiliation: a Department of Otolaryngology, Asan Medical Center , University of Ulsan College of Medicine , Seoul , Republic of Korea ;
authors.forename: Soon Yuhl
authors.initials: SY
authors.lastname: Nam
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D018714:Radiotherapy, Adjuvant; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies
keywords: Advanced larynx cancer; head and neck cancer; lymph node metastasis; radiation therapy; treatment outcome