title: Toxic Effects of Lithium Chloride during Early Neonatal Period of Rat Development.
abstract: Lithium chloride (85, 255, or 255+127 μg/kg) or dexamethasone (0.2 or 2 mg/kg) were subcutaneously injected to 3-day-old rat pups, whose excretory system did not yet attain functional maturity. Both agents retarded the growth of rat pups and delayed the appearance of negative geotaxis. LD50 and therapeutic index of lithium chloride were 255 μg/kg and TI≤3, respectively. Thus, lithium salts even in low doses can be highly toxic for the developing organism.
authors.affiliation: Department of Physiology, Novosibirsk State University, Novosibirsk, Russia. dxkorell@gmail.com.
authors.forename: P N
authors.initials: PN
authors.lastname: Menshanov
authors.affiliation: Department of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Bannova
authors.affiliation: Department of Physiology, Novosibirsk State University, Novosibirsk, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Dygalo
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D003907:Dexamethasone / Q000494:pharmacology*; D053208:Kaplan-Meier Estimate; D018021:Lithium Chloride / Q000633:toxicity*; D023421:Models, Animal; D011619:Psychotropic Drugs / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011619:Psychotropic Drugs; D003907:Dexamethasone; D018021:Lithium Chloride
keywords: behavior; half-lethal dose; lithium; organismal development; rat neonatal ontogeny