title: A convenient method for the synthesis of α-carboxylate ester bromolactones via bromolactonization of alkenoic diesters.
abstract: We developed a simple and efficient method to construct a variety of α-ester bromolactones in good to excellent yields with high diastereoselectivies. The protocol uses readily prepared malonate ester derivatives as substrates, water as an additive and inexpensive N-bromosuccinimide as the halogen source; no catalyst or toxic additive is required. The resulting substituted bromolactones are the fundamental units of many useful molecules.
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. yyyeung@cuhk.edu.hk.
authors.forename: Ying-Chieh
authors.initials: YC
authors.lastname: Wong
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. yyyeung@cuhk.edu.hk and Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
authors.forename: Ying-Yeung
authors.initials: YY
authors.lastname: Yeung