title: A tandem Prins spirocyclization for the stereoselective synthesis of tetrahydrospiro[chroman-2,4'-pyran] derivatives.
abstract: A novel cascade strategy has been developed for the synthesis of tetrahydrospiro[chroman-2,4'-pyran] derivatives by condensation of aldehydes with 2-(5-hydroxy-3-methylenepentyl)phenol. The reaction proceeds smoothly in the presence of BF3·OEt2 under mild conditions in a highly stereoselective manner leading to a single diastereomer. This approach is simple and convenient for the synthesis of pharmacologically relevant spirochroman scaffolds.
authors.affiliation: Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, India. basireddy@iict.res.in.
authors.forename: B V
authors.initials: BV
authors.lastname: Subba Reddy
authors.affiliation: Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, India. basireddy@iict.res.in and Department of Chemistry, Sri Venkateswara University, Tirupati, 517502, India. dryvrsvu@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Hanuman Reddy
authors.affiliation: Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, India. basireddy@iict.res.in.
authors.forename: Durgaprasad
authors.initials: D
authors.lastname: Medaboina
authors.affiliation: Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.
authors.forename: B
authors.initials: B
authors.lastname: Sridhar
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati, 517502, India. dryvrsvu@gmail.com.
authors.forename: Y V
authors.initials: YV
authors.lastname: Rami Reddy