title: Effect of nebivolol on liver regeneration in an experimental 70% partial hepatectomy model.
abstract: BACKGROUND
  Factors affecting liver regeneration are still relevant. The purpose of this study is to investigate the effect of nebivolol treatment on liver regeneration in rats in which 70% partial hepatectomy was performed.
  
  
  METHODS
  Three groups were created: the control group, the low dose group, and the high dose group, with 20 rats in each group and 70% hepatectomy was performed in all rats. Immediately after partial liver resection, 2 mL physiological saline solution was administered to the control group via oral gavage, 0.5 mg/kg nebivolol was administered via oral gavage to the low dose group and 2 mg/kg nebivolol was administered via oral gavage to the high dose group. On the 1stand 5thdays after liver resection, 10 subjects were sacrificed from each group, and liver weights and the mitotic count and Ki-67 were measured.
  
  
  RESULTS
  Regenerating liver weight on the 1stand 5thdays after partial hepatectomy was statistically different in the low dose and high dose nebivolol groups compared to the control group. Mitotic count on the 1stday after partial hepatectomy was significantly higher in the low dose and high dose nebivolol groups than the control group. There was no statistically significant difference detected between the three groups for the 5thday. On the 1stday, Ki-67 rates were significantly higher in both groups given nebivolol than the control group. However, 5thday results were not statistically significant.
  
  
  CONCLUSIONS
  Nebivolol increases regeneration after partial hepatectomy in rats.
authors.affiliation: Inonu University, Department of Surgery, Malatya, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Sumer
authors.affiliation: Yuksek Ihtisas Hospital, Department of Surgery, Ankara, Turkey. Electronic address: drkadri@gmail.com.
authors.forename: Muhammet Kadri
authors.initials: MK
authors.lastname: Colakoglu
authors.affiliation: Yuksek Ihtisas Hospital, Department of Surgery, Ankara, Turkey.
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Ozdemir
authors.affiliation: Yuksek Ihtisas Hospital, Department of Surgery, Ankara, Turkey.
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Ozsay
authors.affiliation: Yuksek Ihtisas Hospital, Department of Surgery, Ankara, Turkey.
authors.forename: Ozer
authors.initials: O
authors.lastname: İlter
authors.affiliation: Yuksek Ihtisas Hospital, Department of Surgery, Ankara, Turkey.
authors.forename: Erdal Birol
authors.initials: EB
authors.lastname: Bostanci
authors.affiliation: Yuksek Ihtisas Hospital, Department of Surgery, Ankara, Turkey.
authors.forename: Musa
authors.initials: M
authors.lastname: Akoglu
mesh_terms: D058665:Adrenergic beta-1 Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006498:Hepatectomy / Q000379:methods; D008115:Liver Regeneration / Q000187:drug effects*; D000068577:Nebivolol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D058665:Adrenergic beta-1 Receptor Agonists; D000068577:Nebivolol
keywords: liver regeneration; nebivolol; partial hepatectomy