title: Regional hypoplasia of somatosensory cortex in growth-retarded mice (grt/grt).
abstract: Growth-retarded mouse (grt/grt) is a spontaneous mutant that is known as an animal model for primary congenital hypothyroidism caused by resistance to TSH signaling. The regional pattern of cerebral cortical hypoplasia was characterized in grt/grt mice. Ex vivo computed tomography (CT)-based volumetry was examined in four regions of the cerebral cortex, i.e., prefrontal, frontal, parietal and occipito-temporal regions, which were demarcated by structural landmarks on coronal CT images. A region-specific reduced volume of the parietal cortical region covering most of the somatosensory cortex was noted in grt/grt mice rather than in both heterozygous (grt/+) and wild-type (+/+) mice. We concluded that the cortical hypoplasia in grt/grt was seen in identical cortical regions corresponding to human congenital hypothyroidism.
authors.affiliation: Department of Nutrition, Faculty of Medical and Health Sciences, Tsukuba International University, Tsuchiura, Ibaraki, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sawada
authors.affiliation: Department of Medical Physics and Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.|Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, Osaka University, Suita, Osaka, Japan.
authors.forename: Shigeyoshi
authors.initials: S
authors.lastname: Saito
authors.affiliation: Department of Nutrition, Faculty of Medical and Health Sciences, Tsukuba International University, Tsuchiura, Ibaraki, Japan.
authors.forename: Akari
authors.initials: A
authors.lastname: Sugasawa
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.|Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
authors.forename: Chika
authors.initials: C
authors.lastname: Sato
authors.affiliation: Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Aoyama
authors.affiliation: Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Ohara
authors.affiliation: Department of Nursing, Ibaraki Christian University, Hitachi, Ibaraki, Japan.
authors.forename: Miwa
authors.initials: M
authors.lastname: Horiuchi-Hirose
authors.affiliation: Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D054893:Cone-Beam Computed Tomography; D003409:Congenital Hypothyroidism / Q000175:diagnosis* / Q000235:genetics; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000235:genetics; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D013003:Somatosensory Cortex / Q000473:pathology*; D055114:X-Ray Microtomography
keywords: computed tomography; growth-retarded mouse; hypothyroidism; somatosensory cortex; volumetry