title: ANTIBIOTIC RESISTANCE PATTERNS OF URINARY TRACT INFECTIONS IN A NORTHEASTERN BRAZILIAN CAPITAL.
abstract: Urinary tract infection is a common problem worldwide. Its clinical characteristics and susceptibility rates of bacteria are important in determining the treatment of choice and its duration. This study assessed the frequency and susceptibility to antimicrobials of uropathogens isolated from community-acquired urinary tract infections in the city of Natal, Rio Grande do Norte State capital, northeastern Brazil, from 2007 to 2010. A total of 1,082 positive samples were evaluated; E. coli was the most prevalent pathogen (60.4%). With respect to the uropathogens susceptibility rates, the resistance of enterobacteria to ciprofloxacin and sulfamethoxazole-trimethoprim was 24.4% and 50.6%, respectively. Susceptibility was over 90% for nitrofurantoin, aminoglycosides and third-generation cephalosporins. High resistance rates of uropathogens to quinolones and sulfamethoxazole-trimethoprim draws attention to the choice of these drugs on empirical treatments, especially in patients with pyelonephritis. Given the increased resistance of community bacteria to antimicrobials, local knowledge of susceptibility rates of uropathogens is essential for therapeutic decision making regarding patients with urinary tract infections.
authors.affiliation: Departamento de Infectologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil, mirellaac@gmail.com; gabriela_lins@hotmail.com; iaramcarrilho@gmail.com; mariserf@gmail.com.
authors.forename: Mirella Alves
authors.initials: MA
authors.lastname: Cunha
authors.affiliation: Departamento de Infectologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil, mirellaac@gmail.com; gabriela_lins@hotmail.com; iaramcarrilho@gmail.com; mariserf@gmail.com.
authors.forename: Gabriela Lins Medeiros
authors.initials: GL
authors.lastname: Assunção
authors.affiliation: Departamento de Infectologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil, mirellaac@gmail.com; gabriela_lins@hotmail.com; iaramcarrilho@gmail.com; mariserf@gmail.com.
authors.forename: Iara Marques
authors.initials: IM
authors.lastname: Medeiros
authors.affiliation: Departamento de Infectologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil, mirellaac@gmail.com; gabriela_lins@hotmail.com; iaramcarrilho@gmail.com; mariserf@gmail.com.
authors.forename: Marise Reis
authors.initials: MR
authors.lastname: Freitas
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001938:Brazil; D024881:Drug Resistance, Bacterial; D005260:Female; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D014552:Urinary Tract Infections / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents