title: Peptide Glycosylation Generates Supramolecular Assemblies from Glycopeptides as Biomimetic Scaffolds for Cell Adhesion and Proliferation.
abstract: Glycopeptide-based hydrogelators with well-defined molecular structures and varied contents of sugar moieties were prepared via in vitro peptide glycosylation reactions. With systematic glucose modification, these glycopeptide hydrogelators exhibited diverse self-assembling behaviors in water and formed supramolecular hydrogels with enhanced thermostability and biostability, in comparison with their peptide analogue. Moreover, because of high water content and similar structural morphology and composition to extracellular matrixes (ECM) in tissues, these self-assembled hydrogels also exhibited great potential to act as new biomimetic scaffolds for mammalian cell growth. Therefore, peptide glycosylation proved to be an effective means for peptide modification and generation of novel supramolecular hydrogelators/hydrogels with improved biophysical properties (e.g., high biostability, increased thermostability, and cell adhesion) which could promise potential applications in regenerative medicine.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou, 215123, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Biology and Basic Medical Science, Soochow University , Suzhou, 215123, China.
authors.forename: Ziling
authors.initials: Z
authors.lastname: Sun
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou, 215123, China.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: School of Biology and Basic Medical Science, Soochow University , Suzhou, 215123, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tian
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou, 215123, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Biology and Basic Medical Science, Soochow University , Suzhou, 215123, China.
authors.forename: Guangxin
authors.initials: G
authors.lastname: Duan
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou, 215123, China.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou, 215123, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Department of Materials Science and Engineering, National Chiao Tung University , Hsinchu, 300, Taiwan.
authors.forename: Hsin-Chieh
authors.initials: HC
authors.lastname: Lin
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou, 215123, China.|State Key Laboratory of Molecular Engineering of Polymers, Fudan University , Shanghai 200433, China.
authors.forename: Xinming
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D005347:Fibroblasts / Q000378:metabolism*; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006031:Glycosylation; D051379:Mice; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D006023:Glycoproteins
keywords: glycopeptide; hydrogel; peptide; self-assembly; supramolecular