title: Primary Cardiac Osteosarcoma.
abstract: BACKGROUND
  Primary cardiac osteosarcoma is extremely rare. There is no cohort study on such tumours to date. The aim of this study is to investigate the clinical characteristics and outcome patterns of such tumours.
  
  
  METHODS
  A thorough literature review was performed, and all relevant clinical items were collected. A total of 53 cases of primary cardiac osteosarcoma were enrolled in this study, including 25 males and 28 females.
  
  
  RESULTS
  The age at diagnosis ranged from 14 to 77 years with a mean age of 43.6 years. The clinical manifestations, imaging features, and laboratory tests of the primary cardiac osteosarcomas were similar to other types of primary cardiac tumours. Sex, tumour size and adjunctive chemo-radiotherapy were found to affect the overall survival pattern.
  
  
  CONCLUSIONS
  The present study may provide an effective consultation for the diagnosis and treatment of this tumour.
authors.affiliation: Department of Pathology, The Affiliated Hospital of Qingdao University, People's Republic of China; Department of Pathology, School of Basic Medical Sciences, Fudan University, People's Republic of China.
authors.forename: Ji-Gang
authors.initials: JG
authors.lastname: Wang
authors.affiliation: Department of Vascular Surgery, The Affiliated Hospital of Qingdao University, People's Republic of China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Pathology, Qingdao Municipal Hospital, People's Republic of China.
authors.forename: Han
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Pathology, The Affiliated Hospital of Qingdao University, People's Republic of China.
authors.forename: Yu-Jun
authors.initials: YJ
authors.lastname: Li
authors.affiliation: Department of Pathology, The Affiliated Hospital of Qingdao University, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.affiliation: Department of Pathology, The Fifth Peoples' Hospital of Shanghai, Fudan University, People's Republic of China; Department of Pathology, School of Basic Medical Sciences, Fudan University, People's Republic of China. Electronic address: xpliu1228@fudan.edu.cn.
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006338:Heart Neoplasms / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000453:epidemiology* / Q000473:pathology
keywords: Cardiac tumour; Osteosarcoma; Prognosis