title: Amyloid Beta (Aβ) Peptide and Factors that Play Important Roles in Alzheimer's Disease.
abstract: Amyloid beta peptide (Aβ) is recognised as a main feature of Alzheimer's disease (AD). Increasing evidence suggests that small soluble oligomers of Aβ are the toxic form of the peptide and may instigate AD. Different factors including some key residues within Aβ molecule, the cell membrane, prion protein and metals play important roles in developing AD. Significant progress has been made to understand these factors and elucidate the mechanism of cytotoxicity of Aβ. This review summarizes recent findings in the area of Aβ and AD research, and this current knowledge could enable medicinal chemists to design and develop therapeutics to treat AD.
authors.forename: Elaheh
authors.initials: E
authors.lastname: Jamasbi
authors.forename: John D
authors.initials: JD
authors.lastname: Wade
authors.forename: Frances
authors.initials: F
authors.lastname: Separovic
authors.affiliation: School of Chemistry, Bio21 Institute, University of Melbourne, VIC 3010; and The Florey Institute of Neuroscience and Mental Health, University of Melbourne, VIC 3010, Australia. akhter.hossain@unimelb.edu.au.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Hossain
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D015195:Drug Design; D006801:Humans
chemical_list: D016229:Amyloid beta-Peptides