title: Reynolds shear stress for textile prosthetic heart valves in relation to fabric design.
abstract: The most widely implanted prosthetic heart valves are either mechanical or bioprosthetic. While the former suffers from thrombotic risks, the latter suffers from a lack of durability. Textile valves, alternatively, can be designed with durability and to exhibit hemodynamics similar to the native valve, lowering the risk for thrombosis. Deviations from native valve hemodynamics can result in an increased Reynolds Shear Stress (RSS), which has the potential to instigate hemolysis or shear-induced thrombosis. This study is aimed at characterizing flow in multiple textile valve designs with an aim of developing a low profile valve. Valves were created using a shaping process based on heating a textile membrane and placed within a left heart simulator. Turbulence and bulk hemodynamics were assessed through particle imaging velocimetry, along with flow and pressure measurements. Overall, RSS was reduced for low profile valves relative to high profile valves, but was otherwise similar among low profile valves involving different fabric designs. However, leakage was found in 3 of the 4 low profile valve designs driving the fabric design for low profile valves. Through textile design, low profile valves can be created with favorable hemodynamics.
authors.affiliation: Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, United States; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, United States.
authors.forename: David L
authors.initials: DL
authors.lastname: Bark
authors.affiliation: Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, United States; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States.
authors.forename: Atieh
authors.initials: A
authors.lastname: Yousefi
authors.affiliation: School of Biomedical Engineering, Colorado State University, Fort Collins, CO, United States.
authors.forename: Marcio
authors.initials: M
authors.lastname: Forleo
authors.affiliation: Université de Haute Alsace/ENSISA-LPMT, Mulhouse, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Vaesken
authors.affiliation: Université de Haute Alsace/ENSISA-LPMT, Mulhouse, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Heim
authors.affiliation: Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, United States; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, United States; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States. Electronic address: Dasi.1@OSU.edu.
authors.forename: Lakshmi P
authors.initials: LP
authors.lastname: Dasi
mesh_terms: D006350:Heart Valve Prosthesis; D006351:Heart Valves; D006439:Hemodynamics; D006801:Humans; D011474:Prosthesis Design; D013314:Stress, Mechanical; D013784:Textiles
keywords: Heart valve; Surface roughness; Textile valve; Turbulence