title: Genetic variants associated with neurodegenerative Alzheimer disease in natural models.
abstract: The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models-most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer diseases, in order to explain their relationships with variants associated with the occurrence of the disease in humans.
authors.affiliation: Facultad de Ciencia, Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile. csalazars87@gmail.com.
authors.forename: Claudia
authors.initials: C
authors.lastname: Salazar
authors.affiliation: Facultad de Ciencia, Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile. gonzalo.vu@gmail.com.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Valdivia
authors.affiliation: Facultad de Ciencia, Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile. alvaro.ardiles@cinv.cl.
authors.forename: Álvaro O
authors.initials: ÁO
authors.lastname: Ardiles
authors.affiliation: Facultad de Ciencia, Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile. john.ewer@uv.cl.
authors.forename: John
authors.initials: J
authors.lastname: Ewer
authors.affiliation: Facultad de Ciencia, Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile. adrian.palacios@uv.cl.|Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Pasaje Harrington 287, Playa Ancha, 2360102, Valparaíso, Chile. adrian.palacios@uv.cl.
authors.forename: Adrián G
authors.initials: AG
authors.lastname: Palacios
mesh_terms: D000375:Aging / Q000235:genetics; D000544:Alzheimer Disease / Q000235:genetics*; D000818:Animals; D030801:Animals, Genetically Modified; D058893:DNA Barcoding, Taxonomic; D004195:Disease Models, Animal; D014644:Genetic Variation; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D051381:Rats; D020539:Sequence Analysis, Protein