title: [Clinical Analysis of 22 Cases of Pulmonary Large Cell Neuroendocrine Cancer].
abstract: BACKGROUND
  Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare primary malignant tumor. Due to poor understanding of its biologic behaviors, pathological features, image manifestations and clinical effects, clinical study is urgent. Analysis of clinical data of pulmonary LCNEC, in order to improve the clinical diagnosis and treatment.
  
  
  METHODS
  Retrospective analysis of 22 pulmonary LCNEC cases of clinical features, diagnosis, treatments and prognosis.
  
  
  RESULTS
  Pulmonary large cell neuroendocrine carcinoma occurs in older men with heavy smoking history., clinical symptoms are cough, sputum, hemoptysis, and chest pain. Computed tomography (CT) features are peripheral mass mainly, accompanied by heterogeneous density and necrosis. Immunohistochemical neuroendocrine differentiation markers Syn, CgA and CD56 positive expression rates were: 72.7%, 68.2% and 68.2%, respectively. 17 patients underwent surgical treatment, 10 patients received adjuvant therapy, 5 underwent palliative chemotherapy. Univariate analysis indicated that smoking index (P=0.029), lymph node metastasis (P=0.034), tumor-node-metastasis (TNM) stage (P=0.005), treatment (P=0.047), postoperative chemotherapy (P=0.014) are prognostic factors. Multivariate analysis showed that lymph node metastasis (P=0.045) and postoperative chemotherapy (P=0.024) are prognostic factors.
  
  
  CONCLUSIONS
  Pulmonary LCNEC is lack of specific clinical symptoms, and its pathological diagnosis depends on postoperative specimens, poor efficacy of various treatments is its current situation. Lymph node metastasis and postoperative chemotherapy are important prognostic factors.
authors.affiliation: Department of General Medicine, Beijing Chest Hospital, Capital Medical University/Beijing  Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Qian
authors.affiliation: Department of General Medicine, Beijing Chest Hospital, Capital Medical University/Beijing  Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of General Medicine, Beijing Chest Hospital, Capital Medical University/Beijing  Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Pathology, Beijing Chest Hospital, Capital Medical University/Beijing  Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of General Medicine, Beijing Chest Hospital, Capital Medical University/Beijing  Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
authors.forename: Qunhui
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of General Medicine, Beijing Chest Hospital, Capital Medical University/Beijing  Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
authors.forename: Baolan
authors.initials: B
authors.lastname: Li
mesh_terms: D000368:Aged; D019002:CD56 Antigen / Q000235:genetics / Q000378:metabolism; D018287:Carcinoma, Large Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D018278:Carcinoma, Neuroendocrine / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D005260:Female; D015292:Glycoprotein Hormones, alpha Subunit / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D012189:Retrospective Studies
chemical_list: D019002:CD56 Antigen; C554042:CGA protein, human; D015292:Glycoprotein Hormones, alpha Subunit