title: 1, 2-Benzisoxazole: A Privileged Structure with a Potential for Polypharmacology.
abstract: Privileged structures are potentially able to bind to a diverse range of biologically important proteins with high affinities, thus benefiting the discovery of novel bioactive compounds. 1,2-Benxisoxazole derivatives can be such important types of "privileged structures" possessing a rich diversity of biological properties especially in the area of CNS disorders.
  
  
  
  This review seeks to explore the most significant examples of 1,2-benzisoxazoles as privileged structures in terms of polypharmacology at the molecular level, specifically focusing on four 1,2-benzisoxazoles (zonisamide, risperidone, paliperidone, and iloperidone) which have been in clinical use and established as effective therapeutics. Furthermore, an updated and detailed account of the pharmacological properties of 1,2-benzisoxazole derivatives as therapeutics for CNS disorders is described. And finally, outlooks on current issues and future directions in this field are also provided.
  
  
  
  1,2-Benzisoxazole was successfully employed in the discovery and development of zonisamide for the treatment of epilepsy and Parkinson's disease. 1,2- Benzisoxazole is also a significantly important structure for the development of atypical antipsychotics.
  
  
  
  It is very reasonable to say that 1,2-benzisoxazole is a good example of a privileged structure because it forms the centerpiece of small molecule chemical entities with a wide range of pharmacological properties, especially in the area of CNS disorders.
authors.affiliation: Venture Science Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140- 8710, Japan. uto.yoshikazu.pw@daiichisankyo.co.jp.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Uto
mesh_terms: D002491:Central Nervous System Agents / Q000737:chemistry / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D006801:Humans; D007555:Isoxazoles / Q000737:chemistry / Q000627:therapeutic use*; D015394:Molecular Structure; D064798:Polypharmacology
chemical_list: C441200:1,2-benzisoxazole; D002491:Central Nervous System Agents; D007555:Isoxazoles