title: N-Arylation of Tertiary Amines under Mild Conditions.
abstract: A transition-metal-free procedure for the N-arylation of tertiary amines to sp(3) quaternary ammonium salts is described. The presented conditions allow for the isolation of trialkylaryl, dialkyldiaryl, and novel triarylalkyl ammonium salts, including N-chiral quaternary ammonium salts. The reaction works at room temperature, open to air with electron-rich or -poor benzyne precursors and different tertiary amines, allowing the synthesis of a broad range of N-aryl ammonium salts that have applications in a variety of fields.
authors.affiliation: Schulich Faculty of Chemistry, Technion-Israel Institute of Technology , Haifa, Israel.
authors.forename: Maayan
authors.initials: M
authors.lastname: Hirsch
authors.affiliation: Schulich Faculty of Chemistry, Technion-Israel Institute of Technology , Haifa, Israel.
authors.forename: Shubhendu
authors.initials: S
authors.lastname: Dhara
authors.affiliation: Schulich Faculty of Chemistry, Technion-Israel Institute of Technology , Haifa, Israel.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Diesendruck