title: Clinical Significance of the Glasgow Prognostic Score for Survival after Colorectal Cancer Surgery.
abstract: Glasgow prognostic score (GPS) has been found to be a useful tool in various cancer types. Our aim was to evaluate the significance of GPS in patients operated on for colorectal cancer (CRC). Patients with CRC who underwent radical resections between April 2010 and January 2015 were retrospectively evaluated. GPS was estimated based on the preoperative measurement of C-reactive protein and serum albumin levels. Data including demographics, laboratory and pathological parameters, surgical outcomes, and late-term follow-up results were analyzed. The study group of 115 patients consisted of 51 (44 %) women and 64 (56 %) men with a median age of 66 (range 32-91) years. The mean follow-up period was 20 (range 7-41) months. Tumor size and wound infection rates were significantly increased in patients with higher GPS (p = 0.019 and p = 0.003, respectively). According to multivariate analyses, CEA and GPS were found to be independent risk factors significantly effecting mortality (p = 0.001 and p = 0.009, respectively). At the end of the late-term follow-up period, it was detected that cancer-specific survival significantly decreased as the GPS increased (p = 0.016). The GPS is a significant prognostic factor in CRC and should be included in the routine preoperative assessment of all surgically treated CRC patients.
authors.affiliation: Department of General Surgery, School of Medicine, Istanbul Medeniyet University Goztepe Training & Research Hospital, Dr. Erkin Street, Kadikoy, 34730, Istanbul, Turkey. drtunceren@gmail.com.
authors.forename: Tunc
authors.identifier: 0000-0001-7651-4321
authors.initials: T
authors.lastname: Eren
authors.affiliation: Department of General Surgery, School of Medicine, Istanbul Medeniyet University Goztepe Training & Research Hospital, Dr. Erkin Street, Kadikoy, 34730, Istanbul, Turkey.
authors.forename: Busra
authors.initials: B
authors.lastname: Burcu
authors.affiliation: Department of General Surgery, School of Medicine, Istanbul Medeniyet University Goztepe Training & Research Hospital, Dr. Erkin Street, Kadikoy, 34730, Istanbul, Turkey.
authors.forename: Ercument
authors.initials: E
authors.lastname: Tombalak
authors.affiliation: Department of General Surgery, School of Medicine, Istanbul Medeniyet University Goztepe Training & Research Hospital, Dr. Erkin Street, Kadikoy, 34730, Istanbul, Turkey.
authors.forename: Tugrul
authors.initials: T
authors.lastname: Ozdemir
authors.affiliation: Department of General Surgery, School of Medicine, Istanbul Medeniyet University Goztepe Training & Research Hospital, Dr. Erkin Street, Kadikoy, 34730, Istanbul, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Leblebici
authors.affiliation: Department of General Surgery, School of Medicine, Istanbul Medeniyet University Goztepe Training & Research Hospital, Dr. Erkin Street, Kadikoy, 34730, Istanbul, Turkey.
authors.forename: Ibrahim Ali
authors.initials: IA
authors.lastname: Ozemir
authors.affiliation: Department of Thoracic Surgery (Medical Statistics), School of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Sedat
authors.initials: S
authors.lastname: Ziyade
authors.affiliation: Department of General Surgery, School of Medicine, Istanbul Medeniyet University Goztepe Training & Research Hospital, Dr. Erkin Street, Kadikoy, 34730, Istanbul, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Alimoglu
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D003661:Decision Support Techniques; D005260:Female; D005500:Follow-Up Studies; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012007:Rectum / Q000601:surgery*; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: Colorectal neoplasms; General surgery; Survival