title: ABERRANT RESTING-STATE BRAIN ACTIVITY IN POSTTRAUMATIC STRESS DISORDER: A META-ANALYSIS AND SYSTEMATIC REVIEW.
abstract: About 10% of trauma-exposed individuals develop PTSD. Although a growing number of studies have investigated resting-state abnormalities in PTSD, inconsistent results suggest a need for a meta-analysis and a systematic review.
  
  
  
  We conducted a systematic literature search in four online databases using keywords for PTSD, functional neuroimaging, and resting-state. In total, 23 studies matched our eligibility criteria. For the meta-analysis, we included 14 whole-brain resting-state studies, reporting data on 663 participants (298 PTSD patients and 365 controls). We used the activation likelihood estimation approach to identify concurrence of whole-brain hypo- and hyperactivations in PTSD patients during rest. Seed-based studies could not be included in the quantitative meta-analysis. Therefore, a separate qualitative systematic review was conducted on nine seed-based functional connectivity studies.
  
  
  
  The meta-analysis showed consistent hyperactivity in the ventral anterior cingulate cortex and the parahippocampus/amygdala, but hypoactivity in the (posterior) insula, cerebellar pyramis and middle frontal gyrus in PTSD patients, compared to healthy controls. Partly concordant with these findings, the systematic review on seed-based functional connectivity studies showed enhanced salience network (SN) connectivity, but decreased default mode network (DMN) connectivity in PTSD.
  
  
  
  Combined, these altered resting-state connectivity and activity patterns could represent neurobiological correlates of increased salience processing and hypervigilance (SN), at the cost of awareness of internal thoughts and autobiographical memory (DMN) in PTSD. However, several discrepancies between findings of the meta-analysis and systematic review were observed, stressing the need for future studies on resting-state abnormalities in PTSD patients.
authors.affiliation: Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: Saskia B J
authors.initials: SB
authors.lastname: Koch
authors.affiliation: Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: Mirjam
authors.initials: M
authors.lastname: van Zuiden
authors.affiliation: Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: Laura
authors.initials: L
authors.lastname: Nawijn
authors.affiliation: Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: Jessie L
authors.initials: JL
authors.lastname: Frijling
authors.affiliation: Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Dick J
authors.initials: DJ
authors.lastname: Veltman
authors.affiliation: Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.|Arq Psychotrauma Expert Center, Diemen, the Netherlands.
authors.forename: Miranda
authors.initials: M
authors.lastname: Olff
mesh_terms: D001921:Brain / Q000503:physiopathology*; D003952:Diagnostic Imaging / Q000379:methods*; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D012146:Rest; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology*
keywords: PTSD; functional connectivity; meta-analysis; resting state; review