title: MALT lymphoma of the base of the tongue: a rare case entity.
abstract: Lymphoma is a malignant tumour arising from lymphoid tissue, with the majority of cases being in the lymph nodes, however, in 1/4th of cases, these tumours are found in extralymphoid tissue. Lymphoid tissue is also found in organs having mucosa, such as the digestive tract, salivary gland and in tracheal tissue. This collection of lymphoid tissue is known as mucosa-associated lymphoid tissue (MALT), and non-Hodgkin lymphoma involving this extralymphoidal lymph tissue is known as MALT lymphoma. It was first reported by Isaacson and Wright in 1983, however, it was not included as a working diagnosis in clinical use until it was reclassified as 'marginal zone B-cell lymphoma' in a 1994 Revised European American Lymphoma (REAL) classification. It is rarely seen in the head and neck region, and we report the sixth case of MALT lymphoma of the base of the tongue. A 61-year-old man presented with dysphagia and the feeling of a lump in his throat for 5 months.
authors.affiliation: Section of Otolaryngology, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Haissan
authors.initials: H
authors.lastname: Iftikhar
authors.affiliation: Section of Otolaryngology, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Moghira Iqbaluddin
authors.initials: MI
authors.lastname: Siddiqui
authors.affiliation: Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
authors.forename: Khurram
authors.initials: K
authors.lastname: Minhas
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone