title: Hepatoprotective Efficacy of Cichorium intybus L. Extract Against Carbon Tetrachloride-induced Liver Damage in Rats.
abstract: The purpose of the study was to assess the phytochemical and hepatoprotective activity of different extracts of dried herb of Cichorium intybus L. against carbon tetrachloride (CCl4) intoxicated male albino rats. The hepatoprotective activity of different extracts at 500 mg/kg body weight was compared with carbon tetrachloride-treated animals. The animals were divided into five groups with six animals in each group. The first group represents control, the second group received carbon tetrachloride, the third received C. intybus, and the fourth group received C. intybus plus carbon tetrachloride. The fifth group received silymarin as hepato-slandered drug. There were significant changes in serum biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin, albumin, total protein, and γ-glutamyl transferase (GGT) in carbon tetrachloride intoxicated rats, which were restored towards normal values in C. intybus-treated animals. Histopathological examination of liver tissues further substantiated these findings. In conclusion, of this investigation, the results ascertain that the herb extracts of C. intybus possess significant hepatoprotective activity.
authors.affiliation: a Medicinal & Aromatic Plants Department , National Research Centre (NRC) , Dokki , Giza , Egypt.
authors.forename: Souad
authors.initials: S
authors.lastname: Elgengaihi
authors.affiliation: b Environmental Toxicology Research Unit (ETRU), Pesticide Chemistry Department , National Research Centre (NRC) , Dokki , Giza , Egypt.
authors.forename: Abdel-Tawab H
authors.initials: AT
authors.lastname: Mossa
authors.affiliation: b Environmental Toxicology Research Unit (ETRU), Pesticide Chemistry Department , National Research Centre (NRC) , Dokki , Giza , Egypt.
authors.forename: Amel A
authors.initials: AA
authors.lastname: Refaie
authors.affiliation: a Medicinal & Aromatic Plants Department , National Research Centre (NRC) , Dokki , Giza , Egypt.
authors.forename: Doha
authors.initials: D
authors.lastname: Aboubaker
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001835:Body Weight; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D018651:Cichorium intybus / Q000737:chemistry*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D064209:Phytochemicals / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D059808:Polyphenols / Q000494:pharmacology; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism; D012838:Silymarin / Q000494:pharmacology; D023382:Toxicity Tests, Acute; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D064209:Phytochemicals; D010936:Plant Extracts; D059808:Polyphenols; D012709:Serum Albumin; D012838:Silymarin; D002251:Carbon Tetrachloride; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin
keywords: Cichorium intybus; carbon tetrachloride; enzymes. hepatoprotective; rats