title: African swine fever virus: current state and future perspectives in vaccine and antiviral research.
abstract: African swine fever (ASF) is among the most significant of swine diseases for which no effective vaccines and antivirals are available. The disease, which is endemic in Africa, was introduced to Trans-Caucasian countries and the Russian Federation in 2007, where it remains prevalent today among domestic pigs and wild boars. Although some measures were implemented, ASF continues to pose a global risk for all countries, and thereby highlighting the importance of vaccine and antiviral research. In this review, an overview of research efforts toward the development of effective vaccines during the past decades is presented. As an alternative to vaccine development, the current state in antiviral research against ASFV is also presented. Finally, future perspectives in vaccine and antiviral research giving emphasis on some strategies that may allow researchers to develop effective countermeasures against ASF are discussed.
authors.affiliation: Laboratory of cell biology and virology, Institute of Molecular Biology of NAS RA, Yerevan, Armenia; Yerevan State Medical University after M. Heratsi, 0025 Yerevan, Armenia. Electronic address: h_zakaryan@mb.sci.am.
authors.forename: Hovakim
authors.initials: H
authors.lastname: Zakaryan
authors.affiliation: Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Revilla
mesh_terms: D000349:Africa / Q000453:epidemiology; D000357:African Swine Fever / Q000453:epidemiology* / Q000517:prevention & control* / Q000628:therapy; D000358:African Swine Fever Virus / Q000502:physiology*; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D005061:Europe, Eastern / Q000453:epidemiology; D012106:Research / Q000639:trends*; D034421:Sus scrofa; D013552:Swine; D014765:Viral Vaccines / Q000592:standards
chemical_list: D000998:Antiviral Agents; D014765:Viral Vaccines
keywords: African swine fever; Antivirals; Vaccine