title: The Use of Sonographically Guided Botulinum Toxin Type A (Dysport) Injections Into the Tensor Fasciae Latae for the Treatment of Lateral Patellofemoral Overload Syndrome.
abstract: Pain in the anterior and lateral parts of the knee during exercise is a common clinical problem for which current management strategies are often unsuccessful.
  
  
  
  To investigate the effect of an ultrasound-guided botulinum toxin (BT) injection into the tensor fasciae latae (TFL), followed by physical therapy, in patients classified with lateral patellofemoral overload syndrome (LPOS) who failed to respond to conventional treatment.
  
  
  
  Case series; Level of evidence, 4.
  
  
  
  A total of 45 patients (mean ± SD age, 32.4 ± 8.6 years) who met the inclusion criteria of (1) activity-related anterolateral knee symptoms, (2) symptoms lasting longer than 3 months, (3) a pathological abnormality confirmed by magnetic resonance imaging, and (4) previous failed physical therapy received an ultrasound-guided injection of BT into the TFL followed by physical therapy. Patient-reported outcomes were collected at 5 intervals: before the injection; at 1, 4, and 12 weeks after the injection; and at a mean 5 years after the injection. In 42 patients, relative iliotibial band (ITB) length changes were assessed using the modified Ober test at the first 4 time points. A computational model was run to simulate the effect of TFL weakening on gluteus medius (GMed) activity. Statistical analysis was undertaken using 1-way analysis of variance and paired t tests with Bonferroni post hoc correction.
  
  
  
  There was a significant improvement in Anterior Knee Pain Scale scores from before the injection (61 ± 15) to 1 (67 ± 15), 4 (70 ± 16), and 12 weeks (76 ± 16) after the injection and in 87% of patients (39/45 patients available for follow-up) at approximately 5 years (from 62.9 ± 15.4 to 87.0 ± 12.5) after the injection (all P < .010). A significant effect on the modified Ober test was identified as a result of the intervention, with an increase in leg drop found at 1 (3° ± 5°), 4 (4° ± 5°), and 12 (7° ± 6°) weeks after the injection compared with before the injection (all P < .010). Simulating a progressive reduction in TFL strength resulted in corresponding increases in GMed activity during gait.
  
  
  
  An injection of BT into the TFL, combined with physical therapy, resulted in a significant improvement of symptoms in patients with LPOS, which was maintained at 5-year follow-up. This may result from reduced lateral TFL/ITB tension or to an increase in GMed activity in response to inhibition of the TFL.
authors.affiliation: Mechanical Engineering Department, Imperial College London, London, UK Fortius Clinic, London, UK.
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Stephen
authors.affiliation: Chelsea and Westminster Hospital, London, UK.
authors.forename: David W J
authors.initials: DW
authors.lastname: Urquhart
authors.affiliation: Mechanical Engineering Department, Imperial College London, London, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: van Arkel
authors.affiliation: Fortius Clinic, London, UK Chelsea and Westminster Hospital, London, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Ball
authors.affiliation: Imperial College Healthcare National Health Service Trust, London, UK.
authors.forename: Matthew K J
authors.initials: MK
authors.lastname: Jaggard
authors.affiliation: Fortius Clinic, London, UK Chelsea and Westminster Hospital, London, UK.
authors.forename: Justin C
authors.initials: JC
authors.lastname: Lee
authors.affiliation: Fortius Clinic, London, UK church@fortiusclinic.com.
authors.forename: J S
authors.initials: JS
authors.lastname: Church
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005206:Fascia Lata / Q000187:drug effects*; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D046788:Patellofemoral Pain Syndrome / Q000188:drug therapy*; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D019274:Botulinum Toxins, Type A; C542869:abobotulinumtoxinA
keywords: botulinum toxin; iliotibial band syndrome; patellofemoral pain; physical therapy