title: Effect and potential mechanism of action of sea cucumber saponins on postprandial blood glucose in mice.
abstract: Postprandial blood glucose control is the major goal in the treatment of diabetes. Here, we investigated the effect of sea cucumber saponins (SCSs) on postprandial blood glucose levels. SCS inhibited yeast as well as rat intestinal α-glucosidase activity in a dose-dependent manner and showed better inhibition of yeast α-glucosidases compared to the positive control. Further studies were performed using ICR mice treated with SCS and starch or SCS alone by oral gavage. Unexpectedly, SCS increased postprandial blood glucose levels a short time (1 h) after oral gavage. The serum corticosterone (CORT) level showed a consistent correlation with glucose levels. In vitro experiments confirmed that SCS treatment increased the secretion of CORT in the Y1 adrenal cell line. Overall, these studies demonstrated that SCS gavage could inhibit α-glucosidase activity but cannot attenuate postprandial blood glucose level within short time periods. The underlying mechanisms are probably related to increased serum CORT levels.
authors.affiliation: a College of Food Science and Engineering, Ocean University of China , Qingdao , China.
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Fu
authors.affiliation: a College of Food Science and Engineering, Ocean University of China , Qingdao , China.
authors.forename: Min
authors.initials: M
authors.lastname: Wen
authors.affiliation: a College of Food Science and Engineering, Ocean University of China , Qingdao , China.
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Han
authors.affiliation: b Faculty of Health and Social Welfare Sciences, Department of Health and Nutrition Sciences , Nishikyushu University , Saga , Japan.
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Yanagita
authors.affiliation: a College of Food Science and Engineering, Ocean University of China , Qingdao , China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xue
authors.affiliation: a College of Food Science and Engineering, Ocean University of China , Qingdao , China.
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Wang
authors.affiliation: a College of Food Science and Engineering, Ocean University of China , Qingdao , China.
authors.forename: Changhu
authors.initials: C
authors.lastname: Xue
authors.affiliation: a College of Food Science and Engineering, Ocean University of China , Qingdao , China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D045744:Cell Line, Tumor; D003345:Corticosterone / Q000097:blood*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010288:Parenteral Nutrition; D010936:Plant Extracts / Q000737:chemistry; D019518:Postprandial Period; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000201:enzymology; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012616:Sea Cucumbers / Q000737:chemistry*; D013213:Starch / Q000008:administration & dosage; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D012503:Saponins; D013213:Starch; D000520:alpha-Glucosidases; D003345:Corticosterone
keywords: corticosterone; postprandial blood glucose; saponins of sea cucumber; α-glucosidase