title: Host-derived salivary biomarkers in diagnosing periodontal disease: systematic review and meta-analysis.
abstract: To systematically evaluate the accuracy of host-derived salivary biomarkers in the diagnosis of periodontal disease based on the given sensitivity and specificity information.
  
  
  
  Studies were eligible for inclusion if they had compared the diagnostic application of salivary biomarkers with clinical examination of periodontal disease. A detailed search was performed in five databases without restrictions on subject age, chronology, or language. Additionally, a partial grey-literature search was conducted. The revised Quality Assessment of Diagnostic Accuracy Studies tool and Meta-analysis were used to evaluate the selected studies.
  
  
  
  From the 905 screened studies, four were included in the qualitative and quantitative analysis. One biomarker, macrophage inflammatory protein-1α (MIP-1α), had excellent diagnostic accuracy and two, interleukin-1β (IL-1β) and interleukin-6 (IL-6), showed acceptable diagnostic values. However, the only biomarker considered excellent was evaluated in a single study, which may reduce the robustness of the results.
  
  
  
  There is currently limited evidence to confirm the diagnostic capability of salivary biomarkers in the clinical assessment of periodontal disease. Notwithstanding, the summary findings showed the growing importance of salivary biomarker, and can guide larger, well-controlled, diagnostic accuracy studies. Likewise, although not conclusive, MIP-1α, IL-1β, and IL-6 may be promising biomarkers for future studies.
authors.affiliation: Laboratory of Oral Histopathology, Department of Dentistry, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.|Laboratory of Molecular Pharmacology, Department of Pharmacy, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
authors.forename: Caroline L
authors.initials: CL
authors.lastname: de Lima
authors.affiliation: Laboratory of Oral Histopathology, Department of Dentistry, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Acevedo
authors.affiliation: Specialization in Periodontics, Brazilian Dentistry Association, Brasília, Brazil.
authors.forename: Daniela C
authors.initials: DC
authors.lastname: Grisi
authors.affiliation: Department of Oral Surgery and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: Mario
authors.identifier: 0000-0002-7098-5090
authors.initials: M
authors.lastname: Taba
authors.affiliation: Laboratory of Oral Histopathology, Department of Dentistry, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
authors.forename: Eliete
authors.initials: E
authors.lastname: Guerra
authors.affiliation: Department of Dentistry, Brazilian Centre of Evidence-Based Research, Federal University of Santa Catarina, Florianopolis, Brazil.|School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
authors.forename: Graziela
authors.initials: G
authors.lastname: De Luca Canto
mesh_terms: D015415:Biomarkers; D006801:Humans; D053583:Interleukin-1beta; D015850:Interleukin-6; D010510:Periodontal Diseases; D012463:Saliva
chemical_list: D015415:Biomarkers; D053583:Interleukin-1beta; D015850:Interleukin-6
keywords: biological markers; diagnosis; periodontal diseases; review; saliva