title: A polyethylenimine functionalized porous/hollow nanoworm as a drug delivery system and a bioimaging agent.
abstract: A wormstructured and nanosized porous/hollow polyethyleneimine (PEI) functionalized Gd2O3/Fe3O4 composite was fabricated as a drug carrier and a bioimaging agent. The effect of PEI's chain length on the size and morphology of the nanoworm was investigated and the results indicated that the nanoworm modified with PEI (10,000 molecular weight) (designated as p-nanoworm) possessed a suitable size and a porous/hollow structure. Meanwhile, the p-nanoworm could effectively prevent the leakage of Gd ions under different pH conditions because of plenty of amino groups on their surface. Compared with contrast agents of clinical use, the p-nanoworm displayed MR enhancement with a high r1 relaxivity of 5.58 s(-1) mM(-1) per gadolinium atom. Cisplatin (CDDP), a clinical anticancer drug, could be easily loaded into the pores and lumen of the p-nanoworm (p-nanoworm-CDDP) and also controllably released by adjusting the pH value. Cell assay suggested that the p-nanoworm possessed satisfactory biocompatibility and meanwhile could promote CDDP uptake of HeLa cells and enhance the inhibition effect on HeLa cells. In addition, p-nanoworm-CDDP showed a negligible cytotoxicity on normal human cells, indicating that the side effect of CDDP is reduced. Thus, the p-nanoworm could have a potential application for the diagnosis and therapy of cancer.
authors.affiliation: Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences and Anhui Province, Hefei 230031, People's Republic of China. zywu@ipp.ac.cn.
authors.forename: Xiao
authors.initials: X
authors.lastname: Sun
authors.affiliation: Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences and Anhui Province, Hefei 230031, People's Republic of China. zywu@ipp.ac.cn and University of Science and Technology of China, Hefei 230026, People's Republic of China. glz1531@mail.ustc.edu.cn.
authors.forename: Chuanjie
authors.initials: C
authors.lastname: Cai
authors.affiliation: School of Life Sciences, Anhui Agricultural University, Hefei 230036, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences and Anhui Province, Hefei 230031, People's Republic of China. zywu@ipp.ac.cn.
authors.forename: Dongqing
authors.initials: D
authors.lastname: Cai
authors.affiliation: High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People's Republic of China. kzhong@hmfl.ac.cn.
authors.forename: Junchao
authors.initials: J
authors.lastname: Qian
authors.affiliation: Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences and Anhui Province, Hefei 230031, People's Republic of China. zywu@ipp.ac.cn and University of Science and Technology of China, Hefei 230026, People's Republic of China. glz1531@mail.ustc.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chi
authors.affiliation: Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, People's Republic of China.
authors.forename: Kang
authors.initials: K
authors.lastname: Zheng
authors.affiliation: School of Life Sciences, Anhui Agricultural University, Hefei 230036, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences and Anhui Province, Hefei 230031, People's Republic of China. zywu@ipp.ac.cn and University of Science and Technology of China, Hefei 230026, People's Republic of China. glz1531@mail.ustc.edu.cn.
authors.forename: Guilong
authors.initials: G
authors.lastname: Zhang
authors.affiliation: High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People's Republic of China. kzhong@hmfl.ac.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhong
authors.affiliation: Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences and Anhui Province, Hefei 230031, People's Republic of China. zywu@ipp.ac.cn.
authors.forename: Zhengyan
authors.initials: Z
authors.lastname: Wu
mesh_terms: D003287:Contrast Media; D016503:Drug Delivery Systems; D008279:Magnetic Resonance Imaging; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D011094:Polyethyleneimine / Q000737:chemistry*; D013818:Thermogravimetry
chemical_list: D003287:Contrast Media; D011094:Polyethyleneimine