title: The role of Toll-like receptors in periodontitis.
abstract: Periodontitis is a common infectious disease. Recent studies have indicated that the progression of periodontitis may be regulated by interactions between host immunity and periodontopathic bacteria. Although periodontopathic bacteria can destroy periodontal tissue, a dysfunctional host immune response triggered by the bacteria can lead to more severe and persistent destruction. Toll-like receptors (TLRs), a type of pattern recognition receptor (PRR) that recognizes pathogens, have been implicated in host innate immune responses to periodontopathic bacteria and in the activation of adaptive immunity. TLR-targeted drugs may hold promise to treat periodontal disease. This review summarizes recent studies on the role of TLRs in periodontitis and discusses areas needing further research. We believe TLRs may be an effective biomarker for the prevention, diagnosis, and treatment of periodontitis in the near future.
authors.affiliation: Guizhou Provincial People's Hospital, Guiyang, China.|Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: B
authors.initials: B
authors.lastname: Song
authors.affiliation: Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Y L
authors.initials: YL
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: L J
authors.initials: LJ
authors.lastname: Chen
authors.affiliation: Guizhou Provincial People's Hospital, Guiyang, China.
authors.forename: T
authors.initials: T
authors.lastname: Zhou
authors.affiliation: Guizhou Provincial People's Hospital, Guiyang, China.
authors.forename: W K
authors.initials: WK
authors.lastname: Huang
authors.affiliation: Guizhou Provincial People's Hospital, Guiyang, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: L Q
authors.initials: LQ
authors.lastname: Shao
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001862:Bone Resorption; D002318:Cardiovascular Diseases / Q000150:complications; D055113:Chronic Periodontitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007378:Interleukins / Q000378:metabolism; D008024:Ligands; D058990:Molecular Targeted Therapy; D000069452:Pathogen-Associated Molecular Pattern Molecules / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015415:Biomarkers; D007378:Interleukins; D008024:Ligands; D000069452:Pathogen-Associated Molecular Pattern Molecules; D051193:Toll-Like Receptors; D014409:Tumor Necrosis Factor-alpha
keywords: TLRs-mediated pathways; Toll-like receptors; periodontitis; periodontopathic bacteria