title: Multiple stage MS in analysis of plasma,  serum, urine and in vitro samples relevant  to clinical and forensic toxicology.
abstract: This paper reviews MS approaches applied to metabolism studies, structure elucidation and qualitative or quantitative screening of drugs (of abuse) and/or their metabolites. Applications in clinical and forensic toxicology were included using blood plasma or serum, urine, in vitro samples, liquids, solids or plant material. Techniques covered are liquid chromatography coupled to low-resolution and high-resolution multiple stage mass analyzers. Only PubMed listed studies published in English between January 2008 and January 2015 were considered. Approaches are discussed focusing on sample preparation and mass spectral settings. Comments on advantages and limitations of these techniques complete the review.
authors.forename: Golo M
authors.initials: GM
authors.lastname: Meyer
authors.forename: Hans H
authors.initials: HH
authors.lastname: Maurer
authors.forename: Markus R
authors.initials: MR
authors.lastname: Meyer
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis / Q000295:instrumentation / Q000379:methods; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D053593:Forensic Toxicology / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000097:blood* / Q000652:urine*; D016482:Urinalysis / Q000295:instrumentation / Q000379:methods
chemical_list: D004364:Pharmaceutical Preparations