title: Regioselective iodoamination of terminal ynamides for the synthesis of α-amino-β,β-diiodo-enamides.
abstract: A mild and efficient methodology involving the I2/TBHP-mediated intermolecular iodoamination of ynamides with amines for the synthesis of α-amino-β,β-diiodo-enamides was developed. This reaction provides the first intermolecular iodoamination of terminal alkynes to diiodo-enamines and can be easily applied to a wide range of substrates.
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People's Republic of China. zhuhj@njtech.edu.cn.
authors.forename: Hai
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People's Republic of China. zhuhj@njtech.edu.cn.
authors.forename: Luning
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People's Republic of China. zhuhj@njtech.edu.cn.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People's Republic of China. zhuhj@njtech.edu.cn.
authors.forename: Guangke
authors.initials: G
authors.lastname: He
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People's Republic of China. zhuhj@njtech.edu.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xi
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People's Republic of China. zhuhj@njtech.edu.cn.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000577:Amides / Q000737:chemistry*; D000586:Amination; D007455:Iodine / Q000737:chemistry*
chemical_list: D000577:Amides; D007455:Iodine