title: Meta-analysis of genome-wide association studies identifies three novel loci for saturated fatty acids in East Asians.
abstract: OBJECTIVE
  We aimed to characterize common genetic variants that influence saturated fatty acid concentrations in East Asians.
  
  
  METHODS
  Meta-analysis of genome-wide association studies for circulating SFAs was conducted in two population-based cohorts comprising 3521 participants of Chinese ancestry.
  
  
  RESULTS
  We identified two novel 14:0-associated loci at LMX1A (LIM homeobox transcription factor 1) and AMPD3 (AMP deaminase 3) (P = 5.08 × 10-9and P = 4.33 × 10-8, respectively), and a novel 20:0-associated locus at CERS4 (ceramide synthase 4) (P = 1.76 × 10-10). We also confirmed the previously reported association of FADS1/2-rs102275 with 18:0 (P = 1.12 × 10-5). In addition, the A alleles of rs11042834 in AMPD3 and rs17159388 in CERS4 also exhibited evidence of associations with high-density lipoprotein cholesterol (P = 0.0162 and P = 0.0161, respectively).
  
  
  CONCLUSIONS
  To our knowledge, this is the first GWAS analysis to examine SFA concentrations in East Asian populations. Our findings provide novel evidence that genetic variations of several genes from multiple pathways are associated with SFA concentrations in human body.
authors.affiliation: The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.|Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Ani
authors.initials: A
authors.lastname: Manichaikul
authors.affiliation: The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: Yii-Der I
authors.initials: YI
authors.lastname: Chen
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Shuang
authors.initials: S
authors.lastname: Liang
authors.affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Lyn M
authors.initials: LM
authors.lastname: Steffen
authors.affiliation: Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Rich
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Tsai
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.|Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Siscovick
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Rozenn N
authors.initials: RN
authors.lastname: Lemaitre
authors.affiliation: The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China.
authors.forename: Huaixing
authors.initials: H
authors.lastname: Li
authors.affiliation: The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China. xlin@sibs.ac.cn.
authors.forename: Xu
authors.initials: X
authors.lastname: Lin
mesh_terms: D000659:AMP Deaminase / Q000235:genetics; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D002784:Cholesterol / Q000097:blood; D000090943:Delta-5 Fatty Acid Desaturase; D044943:Fatty Acid Desaturases / Q000235:genetics; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D056426:Genetic Loci; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D060005:Genotyping Techniques; D006801:Humans; D060850:LIM-Homeodomain Proteins / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D051049:Sphingosine N-Acyltransferase / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D014280:Triglycerides / Q000097:blood; D014481:United States
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; D005227:Fatty Acids; D060850:LIM-Homeodomain Proteins; C078021:LMX1A protein, human; D014157:Transcription Factors; D014280:Triglycerides; D002784:Cholesterol; D044943:Fatty Acid Desaturases; C000716847:FADS1 protein, human; C000599706:CERS4 protein, human; D051049:Sphingosine N-Acyltransferase; D000659:AMP Deaminase
keywords: Arachidic acid; Chinese; Genome-wide association study; Lipids; Myristic acid