title: In the nick of time: arterial thrombosis on starting combination chemotherapy in metastatic gastric adenocarcinoma.
abstract: A 70-year-old man newly diagnosed with metastatic gastric adenocarcinoma was started on standard first-line palliative chemotherapy with anthracycline (epirubicin), platinum (oxaliplatin) and fluoropyrimidine (capecitabine); EOX combination chemotherapy. 5 days after the first cycle of chemotherapy, he presented with tachycardia with associated severe abdominal and lumbar pains. Initial investigations confirmed life-threatening metabolic acidosis with serum lactate of 9.7 mmol/L (normal range 0.5-2.2 mmol/L). CT angiogram identified acute arterial thrombosis within the abdominal aorta, lumbar and right common iliac artery, which was absent on staging contrast CT scan 6 weeks prior. The patient was immediately anticoagulated and chemotherapy discontinued. Urgent oncology and surgical opinions advised conservative management. The patient responded well to early treatment and survived this acute episode. He was subsequently started on life-long treatment dose enoxaparin and second-line single agent chemotherapy with docetaxel (taxotere), with no reported complications.
authors.affiliation: University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
authors.forename: Ian S
authors.initials: IS
authors.lastname: Boon
authors.affiliation: Oncology Department, Worcestershire Acute NHS Trust, Worcester, UK.
authors.forename: Cheng S
authors.initials: CS
authors.lastname: Boon
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D017984:Enoxaparin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D010166:Palliative Care; D013274:Stomach Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D013927:Thrombosis / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin