title: Prognostic factors in patients with vulvar cancer treated with primary surgery: a single-center experience.
abstract: Vulvar cancer is a relatively rare disease. The aim of this study was to investigate prognostic factors in vulvar squamous cell carcinoma patients treated with primary surgery. Forty cases of vulvar squamous cell carcinoma treated with primary surgery were retrospectively analyzed. Overall survival (OS) and disease-specific survival (DSS) were calculated using the Kaplan-Meier method and prognostic factors were analyzed by multivariate analyses. The median age was 68 years. The FIGO stage distribution was as follows: 18 cases (45.0 %) in stage I, four cases (10.0 %) in stage II, 15 cases (37.5 %) in stage III, and three cases (7.5 %) in stage IV. A radical local excision was performed in 15 patients, and radical vulvectomy in 25 patients, and seven of these patients were treated with postoperative RT. The 5-year DSS rate was 72.6 %, and the 5-year OS rate was 70.3 %. Age and surgical margin ≤5 mm were independent prognostic factors for OS, and positive inguinal LN metastasis and surgical margin ≤5 mm were identified as independent prognostic factors for DSS. Complete radical excision is important regardless of operation mode. Adjuvant treatment should be considered for inguinal LN positive patients.
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara Nishihara, Okinawa, 903-0215 Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Imoto
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara Nishihara, Okinawa, 903-0215 Japan.
authors.forename: Morihiko
authors.initials: M
authors.lastname: Inamine
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara Nishihara, Okinawa, 903-0215 Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Kudaka
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara Nishihara, Okinawa, 903-0215 Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nagai
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara Nishihara, Okinawa, 903-0215 Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Wakayama
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara Nishihara, Okinawa, 903-0215 Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakamoto
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara Nishihara, Okinawa, 903-0215 Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Ooyama
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara Nishihara, Okinawa, 903-0215 Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Aoki
keywords: Inguinal lymph node metastasis; Primary surgery; Surgical margin; Vulvar cancer