title: Brugada Syndrome.
abstract: Brugada syndrome might stay undetected in patients until surviving cardiac arrest. Despite the prominent advances in exploring the disease in the past 2 decades, many questions remain unanswered and the controversies continue. Despite all mutations identified to be associated with the disease, two-thirds of cases have a negative genetic test. Future studies should be more directed on modulating factors and their impact on patients' risk for sudden death to help physicians in risk stratifying their patients and optimally implementing an implantable cardioverter defibrillator to prevent sudden cardiac death.
authors.affiliation: Cardiac Electrophysiology, Cardiology, Department of Internal Medicine, American University of Beirut Faculty of Medicine and Medical Center, 3 Dag Hammarskjold Plaza, 8th Floor, New York, NY 10017, USA; Department of Biochemistry and Molecular Genetics, American University of Beirut Faculty of Medicine and Medical Center, 3 Dag Hammarskjold Plaza, 8th Floor, New York, NY 10017, USA; Department of Biochemistry and Molecular Genetics, American University of Beirut Medical Center, Beirut, Lebanon; Cardiology Division, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address: mr48@aub.edu.lb.
authors.forename: Marwan M
authors.initials: MM
authors.lastname: Refaat
authors.affiliation: Cardiology Division, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Hotait
authors.affiliation: Division of Cardiology, Department of Medicine, University of California San Francisco Medical Center, San Francisco, CA, USA.
authors.forename: Melvin
authors.initials: M
authors.lastname: Scheinman
mesh_terms: D000328:Adult; D053840:Brugada Syndrome; D017147:Defibrillators, Implantable; D004562:Electrocardiography; D006801:Humans; D008297:Male; D062554:NAV1.5 Voltage-Gated Sodium Channel / Q000235:genetics
chemical_list: D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human
keywords: Brugada syndrome; Diagnosis; Implantable cardioverter defibrillator; Sudden cardiac death