title: Association between soluble lectin-like oxidized low-density lipoprotein receptor 1 levels and coronary slow flow phenomenon.
abstract: BACKGROUND
  The coronary slow flow phenomenon (CSFP) has been associated with myocardial ischemia, myocardial infarction, life-threatening arrhythmias, sudden cardiac death and increased cardiovascular mortality similar to coronary artery disease (CAD). Possible underlying mechanisms of CSFP are endothelial dysfunction, chronic inflammation, microvascular dysfunction and diffuse atherosclerosis. Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) seems to play an important role in the pathogenesis of atherosclerosis. We hypothesized that sLOX-1 might be associated with CSFP, and aimed to research the relationship between sLOX-1 and CSFP.
  
  
  METHODS
  Forty patients with angiographically proven CSFP and 43 patients with a normal coronary flow pattern (NCFP) were included in this study. Coronary blood flow was measured according to the Thrombolysis In Myocardial Infarction (TIMI) frame count method. sLOX-1 levels were measured in all study subjects.
  
  
  RESULTS
  Serum levels of sLOX-1 were significantly higher in the CSFP group than the NCFP group (1061.80 ±422.20 ng/ml vs. 500.043 ±282.97 ng/ml, p < 0.001, respectively). Multivariate logistic regression analysis including sLOX-1, MPV, GGT and uric acid levels revealed a significant association between sLOX-1 levels and CSFP (Exp (B)/OR: 1.006, 95% CI: 1.002-1.010, p = 0.001).
  
  
  CONCLUSIONS
  The present study demonstrated that serum sLOX-1 levels were significantly higher in patients with CSFP and there was a strong association between high sLOX-1 levels and CSFP. High serum sLOX-1 levels may have an important role in the pathogenesis of CSFP. Future studies are needed to confirm these results.
authors.affiliation: Department of Cardiology, Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: Ilker Murat
authors.initials: IM
authors.lastname: Caglar
authors.affiliation: Department of Cardiology, Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Ozde
authors.affiliation: Department of Cardiology, Usak State Hospital, Usak, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Biyik
authors.affiliation: Department of Cardiology, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Fatma Nihan Turhan
authors.initials: FN
authors.lastname: Caglar
authors.affiliation: Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ibrahim Faruk
authors.initials: IF
authors.lastname: Akturk
authors.affiliation: Department of Cardiovascular Surgery, School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ugurlucan
authors.affiliation: Department of Cardiology, Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Karakaya
keywords: coronary slow flow phenomenon; soluble lectin-like oxidized low-density lipoprotein receptor 1