title: Behavior and inhibitory control in children with prenatal exposure to antidepressants and medically untreated depression.
abstract: OBJECTIVE
  The present study investigates child development following prenatal exposure to maternal use of selective serotonin reuptake inhibitors (SSRIs; N = 28), versus prenatal exposure to medically untreated depression (N = 42), and no exposure (N = 33).
  
  
  METHODS
  When the children reached 5-6 years of age, child cognitive abilities were measured using selected tests from Wechsler Preschool and Primary Scale of Intelligence-Revised (WPPSI-r), Neuropsychological Assessment II (NEPSY-II), and the Attention Network Test. Maternal reports of child behavioral problems were collected using the Child Behavior Checklist (CBCL).
  
  
  CONCLUSIONS
  Analyses of variance revealed no effects of prenatal exposure to depression or SSRIs upon general cognition or inhibition. Regarding behavioral problems, there was a significant negative association between both SSRI and depression exposure upon externalizing, and between SSRI exposure and internalizing problems. The results are interpreted in light of theories on interactive specialization and reactivity.
authors.affiliation: The Cognitive Developmental Research Unit, Department of Psychology, University of Oslo, Forskningsveien 3a, 0373, Oslo, Norway. t.k.hermansen@psykologi.uio.no.
authors.forename: Tone Kristine
authors.initials: TK
authors.lastname: Hermansen
authors.affiliation: The Cognitive Developmental Research Unit, Department of Psychology, University of Oslo, Forskningsveien 3a, 0373, Oslo, Norway.|The Norwegian Institute of Public Health, Oslo, Norway.
authors.forename: Espen
authors.initials: E
authors.lastname: Røysamb
authors.affiliation: The Cognitive Developmental Research Unit, Department of Psychology, University of Oslo, Forskningsveien 3a, 0373, Oslo, Norway.
authors.forename: Else-Marie
authors.initials: EM
authors.lastname: Augusti
authors.affiliation: The Cognitive Developmental Research Unit, Department of Psychology, University of Oslo, Forskningsveien 3a, 0373, Oslo, Norway.
authors.forename: Annika
authors.initials: A
authors.lastname: Melinder
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002657:Child Development / Q000187:drug effects* / Q000502:physiology; D002675:Child, Preschool; D003071:Cognition / Q000187:drug effects / Q000502:physiology; D015331:Cohort Studies; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000523:psychology*; D011446:Prospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Attention network test; Child behavior; Inhibition; Prenatal SSRI exposure; The Norwegian Mother and Child Cohort Study (MoBa)