title: Development and physicochemical characterization of clindamycin resinate for taste masking in pediatrics.
abstract: OBJECTIVE
  To evaluate the physicochemical characteristics of clindamycin HCl in a complex form (resinate) with ion exchange resin (IER) (Amberlite IRP69).
  
  
  METHODS
  Drug-resin complex was prepared by simple aqueous binding method. Drug binding study was carried out at different drug and resin concentrations. Several physicochemical characterization studies were conducted to evaluate the resinate complex. These studies included flow properties, in vitro drug release in SGF and SIF, DSC, TGA, mass spectroscopy and XPRD evaluations. In addition, stability study of resinate complex was conducted at 25 and 40 °C for up to 1 month.
  
  
  RESULTS
  Clindamycin and Amberlite IRP69 have formed a complex (resinate) and have shown good flow properties, good thermal properties and chemical stability (short term over 4 weeks) at 25 and 40 °C. Clindamycin release profiles from resinate in SGF and SIF have shown immediate release characteristics and release in simulated saliva has shown dependence on water volume.
  
  
  CONCLUSIONS
  The clindamycin stable complex with IER (Amberlite IRP69) has the potential for further development as a compatible pediatric liquid formulation (suspension) or a fast disintegrating tablet.
authors.affiliation: a Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy , Cairo University, Cairo , Egypt ;
authors.forename: Baher
authors.initials: B
authors.lastname: Daihom
authors.affiliation: b Department of Pharmaceutical Sciences, College of Pharmacy , University of Tennessee Health Science Center , Memphis , TN , USA ;
authors.forename: Alaadin
authors.initials: A
authors.lastname: Alayoubi
authors.affiliation: b Department of Pharmaceutical Sciences, College of Pharmacy , University of Tennessee Health Science Center , Memphis , TN , USA ;
authors.forename: Dejian
authors.initials: D
authors.lastname: Ma
authors.affiliation: c Department of Physics , University of Memphis , Memphis , TN , USA ;
authors.forename: Lijia
authors.initials: L
authors.lastname: Wang
authors.affiliation: c Department of Physics , University of Memphis , Memphis , TN , USA ;
authors.forename: Sanjay
authors.initials: S
authors.lastname: Mishra
authors.affiliation: d Department of Clinical Pharmacy, College of Pharmacy , University of Tennessee Health Science Center , Memphis , TN , USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Helms
authors.affiliation: b Department of Pharmaceutical Sciences, College of Pharmacy , University of Tennessee Health Science Center , Memphis , TN , USA ;
authors.forename: Hassan
authors.initials: H
authors.lastname: Almoazen
mesh_terms: D000284:Administration, Oral; D002981:Clindamycin / Q000008:administration & dosage / Q000737:chemistry*; D065546:Drug Liberation; D007475:Ion Exchange Resins / Q000737:chemistry*; D010372:Pediatrics; D012117:Resins, Synthetic / Q000737:chemistry*; D013535:Suspensions; D013607:Tablets; D013649:Taste
chemical_list: D007475:Ion Exchange Resins; D012117:Resins, Synthetic; D013535:Suspensions; D013607:Tablets; D002981:Clindamycin; C046797:amberlite
keywords: Clindamycin HCl; IRP69; ion exchange resin; pediatric formulations; taste masking