title: [Effect of parents' occupational and life environment exposure during six months before pregnancy on executive function of preschool children].
abstract: OBJECTIVE
  To examine the effect of parents' occupational and life exposure during six months before pregnancy on executive function of preschool children.
  
  
  METHODS
  Pregnant women involved in the study came from the Ma'anshan Birth Cohort Study,a part of the China-Anhui Birth Cohort Study. Between October 2008 and October 2010, pregnant women who accepted pregnancy care in four municipal medical and health institutions in Ma'anshan city were recruited as study objects. A total of 5,084 pregnant women and 4,669 singleton live births entered in this cohort. Between April 2014 and April 2015, a total of 3,803 pre-school children were followed up. Finally, except 32 preschool children did not have EF evaluation result, there were 3,771 children included in this study. By using self-designed " Maternal health handbook", we researched parents' general demographic characteristics, and life and occupational exposure during six months before pregnancy. To research preschool children's executive function, we used the Behavior Rating Inventory of Executive Function-Preschool Version (BRIEF-P). Univariate and multivariate statistical method was used to analyze the association of parents' life and occupational exposure during six months before pregnancy and preschool children's EF.
  
  
  RESULTS
  3,771 preschool children's detected rate of inhibitory self-control index (ISCI), flexibility index (FI), emergent metacognition index (EMI) and global executive composite (GEC) dysplasia were 4.8% (182), 2.3% (88), 16.5% (623) and 8.6% (324) respectively. During six months before pregnancy, children whose parents were lived in a noise environment (OR=1.86, 95% CI: 1.36-2.54), whose maternal were exposed to pesticides were the risk of ISCI dysplasia(OR=3.60, 95% CI: 1.45-8.95). During six months before pregnancy, children whose maternal were exposed to pesticides (OR=6.72, 95% CI: 2.50-18.07) and whose father were exposed to occupational lead (OR=2.10, 95% CI: 1.25-3.54) were the risk of FI dysplasia. During six months before pregnancy, children whose parents were lived in a noise environment (OR=1.42, 95%CI: 1.18-1.71) and whose father were exposed to occupational lead (OR=1.30, 95%CI: 1.02-1.65) were the risk of EMI dysplasia. During six months before pregnancy, children whose parents were lived in a noise environment (OR=1.58, 95% CI: 1.24-2.01) and whose maternal were exposed to pesticides (OR=2.39, 95% CI: 1.02-5.58) were the risk of GEC dysplasia.
  
  
  CONCLUSIONS
  The development of executive function is worse among preschool children whose parents live in noise environment, mother exposed to pesticides, and father exposed to occupational lead during six months before pregnancy.
authors.affiliation: Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University; Anhui Provincial Laboratory of Population Health and Eugenics, Hefei 230032, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Ni
authors.forename: Ting
authors.initials: T
authors.lastname: Shao
authors.forename: Huihui
authors.initials: H
authors.lastname: Tao
authors.forename: Yanli
authors.initials: Y
authors.lastname: Sun
authors.forename: Shuangqin
authors.initials: S
authors.lastname: Yan
authors.forename: Chunli
authors.initials: C
authors.lastname: Gu
authors.forename: Hui
authors.initials: H
authors.lastname: Cao
authors.forename: Kun
authors.initials: K
authors.lastname: Huang
authors.forename: Fangbiao
authors.initials: F
authors.lastname: Tao
authors.forename: Shilu
authors.initials: S
authors.lastname: Tong
mesh_terms: D002648:Child; D002675:Child, Preschool; D002681:China; D015331:Cohort Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D056344:Executive Function; D005191:Family Characteristics; D005260:Female; D006801:Humans; D007854:Lead / Q000009:adverse effects; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D010290:Parents; D010575:Pesticides / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology* / Q000523:psychology
chemical_list: D010575:Pesticides; D007854:Lead