title: Increased Periodontal Attachment Loss in Patients With Systemic Sclerosis.
abstract: Patients with inflammatory rheumatic diseases and periodontitis share common pathogenetic characteristics, such as proinflammatory traits causative for tissue degradation and loss of function. The aim of the present case control study is to investigate the association between systemic sclerosis (SSc) and periodontitis.
  
  
  
  The association between SSc and periodontitis was examined in 58 SSc patients and 52 control patients, matched for age and sex. The periodontal examination included periodontal attachment loss (AL), probing depth, bleeding on probing, plaque index (PI), and gingival index (GI). Potential risk factors of periodontitis were assessed through patients' questionnaires.
  
  
  
  In unadjusted analyses, patients with SSc had a significant 0.61 mm higher AL (95% confidence interval [CI] 0.24 to 0.97; P = 0.002) when compared with controls. In a stepwise logistic regression, including SSc status, age, sex, education, smoking, alcohol consumption, and body mass index, only SSc status, age, and sex remained significantly associated with periodontitis. Adjusted for age and sex, patients with SSc had a 0.52 mm higher AL compared with controls (95% CI 0.16 to 0.88; P = 0.005). The strength of the association of SSc with AL remained statistically significant after additional adjustment for PI (0.44 mm; 95% CI 0.02 to 0.86; P = 0.04) or GI (0.61 mm; 95% CI 0.24 to 0.97; P = 0.001).
  
  
  
  This study demonstrates higher AL in patients with SSc, which remained significant after adjustment. The study indicates a possible relationship between SSc and periodontitis.
authors.affiliation: Department of Periodontology and Synoptic Dentistry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Nicole
authors.initials: N
authors.lastname: Pischon
authors.affiliation: Department of Periodontology and Synoptic Dentistry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Hoedke
authors.affiliation: Department of Periodontology and Synoptic Dentistry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Kurth
authors.affiliation: Department of Periodontology and Synoptic Dentistry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Paul
authors.initials: P
authors.lastname: Lee
authors.affiliation: Department of Periodontology and Synoptic Dentistry, Charité-Universitätsmedizin Berlin, Berlin, Germany.|Department of Oral Health Sciences, University of Washington, Seattle, WA.
authors.forename: Henrik
authors.initials: H
authors.lastname: Dommisch
authors.affiliation: Molecular Epidemiology Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin-Buch, Berlin, Germany.
authors.forename: Astrid
authors.initials: A
authors.lastname: Steinbrecher
authors.affiliation: Molecular Epidemiology Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin-Buch, Berlin, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Pischon
authors.affiliation: Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin.
authors.forename: Gerd R
authors.initials: GR
authors.lastname: Burmester
authors.affiliation: Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin.
authors.forename: Frank
authors.initials: F
authors.lastname: Buttgereit
authors.affiliation: Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Detert
authors.affiliation: Department of Rheumatology, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany.|German Rheumatism Research Centre Berlin, Berlin, Germany.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Riemekasten
mesh_terms: D016022:Case-Control Studies; D003774:Dental Plaque Index; D006801:Humans; D017622:Periodontal Attachment Loss; D010512:Periodontal Index; D012595:Scleroderma, Systemic / Q000150:complications*
keywords: Fibrosis; infection; inflammation; oral hygiene; periodontitis; risk factors; scleroderma, systemic