title: Cladosporinone, a new viriditoxin derivative from the hypersaline lake derived fungus Cladosporium cladosporioides.
abstract: A new cytotoxic viriditoxin derivative, cladosporinone (1), along with the known viriditoxin (2) and two viriditoxin derivatives (3 and 4) were obtained from the fungus Cladosporium cladosporioides isolated from the sediment of a hypersaline lake in Egypt. The structure of the new compound (1) was determined by 1D and 2D NMR measurements as well as by high-resolution ESIMS and electronic circular dichroism spectroscopy. All isolated compounds were studied for their cytotoxicity against the murine lymphoma cell line L5187Y and for their antibiotic activity against several pathogenic bacteria. Viriditoxin (2) was the most active compound in both bioassays. Compound 1 also exhibited strong cytotoxicity against the murine lymphoma cell line L5187Y with an IC50 value of 0.88 μm, whereas its antibiotic activity was weak.
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Duesseldorf, Germany.|Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Organic Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Tibor
authors.initials: T
authors.lastname: Kurtán
authors.affiliation: Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China.
authors.forename: Chang
authors.initials: C
authors.lastname: Yun Wang
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, People's Republic of China.
authors.forename: Wen
authors.initials: W
authors.lastname: Han Lin
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, King Saud University, Riyadh, KSA.
authors.forename: Raha
authors.initials: R
authors.lastname: Orfali
authors.affiliation: Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Werner Eg
authors.initials: WE
authors.lastname: Müller
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: Georgios
authors.initials: G
authors.lastname: Daletos
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D002963:Cladosporium / Q000302:isolation & purification / Q000378:metabolism*; D004534:Egypt; D020128:Inhibitory Concentration 50; D060106:Lakes; D008223:Lymphoma / Q000188:drug therapy* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009284:Naphthols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D009284:Naphthols; C010375:viriditoxin