title: Factors Influencing Cognitive Function in Subjects With COPD.
abstract: BACKGROUND
  The aim of this study was to assess the association between cognitive function and age, pulmonary function, comorbidity index, and the 6-min walk distance in subjects with COPD as well as to compare the Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) in terms of their ability to identify cognitive dysfunction in subjects with COPD.
  
  
  METHODS
  A total of 52 individuals with stable COPD were included in this study. Cognitive function was assessed using MMSE and MoCA. Age, body mass index, the Modified Cumulative Illness Rating Scale, 6-min walk distance, arterial blood gases, and pulmonary function tests were assessed and recorded.
  
  
  RESULTS
  The range and SD of scores in subjects with COPD were larger with MoCA than with MMSE. MMSE and MoCA scores are associated with 6-min walk distance and comorbidity index in subjects with COPD. General cognitive function measured by MoCA was negatively correlated with the comorbidity index but was positively associated with 6-min walk distance in subjects with COPD after controlling for possible confounding factors in the multivariate model. However, general cognitive function measured by MMSE was not correlated with the comorbidity index and 6-min walk distance in subjects with COPD, after controlling for possible confounding factors in the multivariate model.
  
  
  CONCLUSIONS
  MoCA may be a more reliable screening test than MMSE in detecting cognitive impairment in subjects with COPD. The addition of cognitive tests on assessment of subjects with COPD can provide further benefit.
authors.affiliation: Department of Neurology.
authors.forename: Ersel
authors.initials: E
authors.lastname: Dag
authors.affiliation: Department of Pulmonary Diseases, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey. emelbulcun@hotmail.com.
authors.forename: Emel
authors.initials: E
authors.lastname: Bulcun
authors.affiliation: Department of Neurology.
authors.forename: Yakup
authors.initials: Y
authors.lastname: Turkel
authors.affiliation: Department of Pulmonary Diseases, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.
authors.forename: Aydanur
authors.initials: A
authors.lastname: Ekici
authors.affiliation: Department of Pulmonary Diseases, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ekici
mesh_terms: D000367:Age Factors; D000368:Aged; D003071:Cognition / Q000502:physiology; D060825:Cognitive Dysfunction / Q000209:etiology* / Q000503:physiopathology; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology / Q000523:psychology*; D012307:Risk Factors; D012720:Severity of Illness Index; D000070857:Walk Test
keywords: Montreal cognitive assessment; chronic obstructive pulmonary disease; cognitive function; mini-mental state examination