title: Regenerative decline of stem cells in sarcopenia.
abstract: Skeletal muscle mass and function decline with aging, a process known as sarcopenia, which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is also linked to a progressive reduction in the regenerative capacity of the skeletal muscle stem cells (satellite cells), which are critical for myofiber formation in early life stages and for sustaining repair in response to muscle damage or trauma. Here we will review the most recent findings on the causes underlying satellite cell functional decline with aging, and will discuss the prevalent view whereby age-associated extrinsic factor alterations impact negatively on satellite cell-intrinsic mechanisms, resulting in deficient muscle regeneration with aging. Further understanding of the interplay between satellite cell extrinsic and intrinsic factors in sarcopenia will facilitate therapies aimed at improving muscle repair in the increasing aging population.
authors.affiliation: Buck Institute for Research on Aging, Novato, CA, USA.
authors.forename: Pedro
authors.initials: P
authors.lastname: Sousa-Victor
authors.affiliation: Cell Biology Group, Department of Experimental and Health Sciences, CIBER on Neurodegenerative Diseases (CIBERNED), Pompeu Fabra University (UPF), Barcelona, Spain; Tissue Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; ICREA, Barcelona, Spain. Electronic address: pura.munoz@upf.edu.
authors.forename: Pura
authors.initials: P
authors.lastname: Muñoz-Cánoves
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D012038:Regeneration / Q000235:genetics; D055948:Sarcopenia / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology / Q000378:metabolism*; D015398:Signal Transduction
keywords: Aging; Disease; Muscle stem cell (satellite cell); Sarcopenia; Skeletal muscle regeneration