title: Visualization of microvasculature and thrombi by X-ray phase-contrast computed tomography in hepatocellular carcinoma.
abstract: Visualization of the microvascular network and thrombi in the microvasculature is a key step to evaluating the development of tumor growth and metastasis, and influences treatment selection. X-ray phase-contrast computed tomography (PCCT) is a new imaging technique that can detect minute changes of density and reveal soft tissues discrimination at micrometer-scale resolution. In this study, six human resected hepatocellular carcinoma (HCC) tissues were investigated with PCCT. A histological stain was added to estimate the accuracy of PCCT. The results showed that the fine structures of the microvasculature (measuring 30-100 µm) and thrombi in tiny blood vessels were displayed clearly on imaging the HCC tissues by PCCT. Moreover, density distributions of the thrombi were obtained, which could be reliably used to distinguish malignant from benign thrombi in HCC. In conclusion, PCCT can clearly show the three-dimensional subtle structures of HCC that cannot be detected by conventional absorption-based computed tomography and provides a new method for the imageology of HCC.
authors.affiliation: College of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, People's Republic of China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Jian
authors.affiliation: College of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Yang
authors.affiliation: Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, People's Republic of China.
authors.forename: Xinyan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: College of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, People's Republic of China.
authors.forename: Ruijiao
authors.initials: R
authors.lastname: Xuan
authors.affiliation: Department of Pathology, Tianjin Medical University General Hospital, Tianjin 300052, People's Republic of China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Medical Imaging, Tianjin Medical University, Tianjin 300203, People's Republic of China.
authors.forename: Dongyue
authors.initials: D
authors.lastname: Li
authors.affiliation: College of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, People's Republic of China.
authors.forename: Chunhong
authors.initials: C
authors.lastname: Hu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000098:blood supply*; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply*; D055806:Microvessels / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: hepatocellular carcinoma (HCC); microvasculature; phase-contrast computed tomography (PCCT); thrombus