title: Restricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cells.
abstract: The most common cancer treatments currently available are radio- and chemo-therapy. These therapies have, however, drawbacks, such as, the reduction in quality of life and the low efficiency of radiotherapy in cases of multiple metastases. To lessen these effects, we have encapsulated an anti-cancer drug into a biocompatible matrix. In-vitro assays indicate that this bio-nanocomposite is able to interact and cause morphological changes in cancer cells. Meanwhile, no alterations were observed in monocytes and fibroblasts, indicating that this system might carry the drug in living organisms with reduced clearance rate and toxicity. X-rays and neutrons were used to investigate the carrier structure, as well as to assess the drug mobility within the bio-nanocomposite. From these unique data we show that partial mobility restriction of active groups of the drug molecule suggests why this carrier design is potentially safer to healthy cells.
authors.affiliation: Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen, Denmark.|Instituto de Biociências - Universidade Estadual Paulista - CP 510, 18618-970 Botucatu-SP, Brazil.
authors.forename: Murillo L
authors.initials: ML
authors.lastname: Martins
authors.affiliation: Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen, Denmark.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Ignazzi
authors.affiliation: Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., Tampa, Florida 33620, United States.|Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
authors.forename: Juergen
authors.initials: J
authors.lastname: Eckert
authors.affiliation: Swiss Light Source, Paul Scherrer Institute, CH-5232 Villigen, Switzerland.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Watts
authors.affiliation: Instituto de Biociências - Universidade Estadual Paulista - CP 510, 18618-970 Botucatu-SP, Brazil.
authors.forename: Ramon
authors.initials: R
authors.lastname: Kaneno
authors.affiliation: Instituto de Biociências - Universidade Estadual Paulista - CP 510, 18618-970 Botucatu-SP, Brazil.
authors.forename: Willian F
authors.initials: WF
authors.lastname: Zambuzzi
authors.affiliation: Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
authors.forename: Luke
authors.initials: L
authors.lastname: Daemen
authors.affiliation: Instituto de Biociências - Universidade Estadual Paulista - CP 510, 18618-970 Botucatu-SP, Brazil.
authors.forename: Margarida J
authors.initials: MJ
authors.lastname: Saeki
authors.affiliation: Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen, Denmark.|European Spallation Source ESS AB, PO Box 176, SE-221 00 Lund, Sweden.
authors.forename: Heloisa N
authors.initials: HN
authors.lastname: Bordallo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004337:Drug Carriers; D017886:Durapatite / Q000737:chemistry; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D009000:Monocytes / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D017886:Durapatite