title: [Treatment of recurrent laryngeal papilloma by submucosal resection and the effect on prognosis].
abstract: OBJECTIVE
  To investigate the efficacy of submucosal resection by CO2 laser in the treatment of recurrent laryngeal papilloma and the effect on prognosis.
  
  
  METHODS
  A total of 11 patients diagnosed as recurrent laryngeal papilloma were included in this review. Papilloma was marked before operation and checked under fibro-laryngoscope. Papilloma was resected completely including the submucosal tissure with CO2 laser or microequipment. In widespread papilloma, false membrane in raw surface were cleared 7-10 days after operation. Surgical specimens (including membrane) were detected by routine pathology, HPV typing and immunohistochemical pathologic examination. The patients were checked once a month in the first 3 months after operation, and then once for every 3 months. Once the hoarseness and other symptoms aggravated or the disease was recurrent, the patients were treated immediately.
  
  
  RESULTS
  HPV viral DNA was found in 10/11 cases, with HPV11 (7/11 cases) and HPV6 (3/11 cases). Cases with regards to follow-up, from 6 months to 1 year, 3 cases were followed up 1 year after operation, without recurrence. Five patients including 2 children were followed up 6 to 12 months after operation, without recurrence. Two children underwent 2 or 3 operations, were followed-up more than 6 months withouting recurrence.
  
  
  CONCLUSIONS
  Papilloma submucosal resection could decrease postoperative recurrence and is worth to be further investigated.
authors.forename: Huiying
authors.initials: H
authors.lastname: Hu
authors.forename: Qingxiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Guoyan
authors.initials: G
authors.lastname: Sun
authors.forename: Zhenkun
authors.initials: Z
authors.lastname: Yu
mesh_terms: D002648:Child; D004279:DNA, Viral / Q000097:blood; D052140:Human papillomavirus 11 / Q000302:isolation & purification; D052163:Human papillomavirus 6 / Q000302:isolation & purification; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000601:surgery*; D020704:Laryngoscopes; D054020:Lasers, Gas; D009364:Neoplasm Recurrence, Local; D010212:Papilloma / Q000175:diagnosis / Q000601:surgery* / Q000821:virology; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000601:surgery*; D011184:Postoperative Period; D011379:Prognosis; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000601:surgery*
chemical_list: D004279:DNA, Viral