title: Sweet Taste Receptor TAS1R2 Polymorphism (Val191Val) Is Associated with a Higher Carbohydrate Intake and Hypertriglyceridemia among the Population of West Mexico.
abstract: Some high-carbohydrate diets may lead to obesity and multiple metabolic disorders, including hypertriglyceridemia (HTG). This lipid abnormality is considered an important risk factor for cardiovascular disease and type 2 diabetes. The sweet taste receptor TAS1R2 polymorphism (Ile191Val) has been reported to be associated with carbohydrate intake. The aim of this study was to analyze the association of the TAS1R2 gene polymorphism with carbohydrate intake and HTG among the population of West Mexico. In a cross-sectional study, 441 unrelated subjects were analyzed for TAS1R2 genotypes (Ile/Ile, Ile/Val and Val/Val) by an allelic discrimination assay. Biochemical tests and a three-day food record were assessed. The Val/Val genotype carriers had a higher intake of total carbohydrates, fiber and servings of cereals and vegetables than the other genotype carriers. The Val/Val genotype conferred a higher risk for HTG than the Ile/Val and Ile/Ile genotypes (OR = 3.26, 95%CI 1.35-7.86, p = 0.006 and OR = 2.61, 95%CI 1.12-6.07, p = 0.02, respectively). Furthermore, the Val/Val genotype was associated with approximately 30% higher triglycerides compared with Ile/Val and Ile/Ile genotypes (β = 44.09, 95%CI 9.94-78.25, p = 0.01 and β = 45.7, 95%CI 10.85-80.54, p = 0.01, respectively). In conclusion, the Val/Val genotype of TAS1R2 was associated with a higher carbohydrate intake and HTG.
authors.affiliation: Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco 44280, Mexico. os_mar6@hotmail.com.|Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico. os_mar6@hotmail.com.
authors.forename: Omar
authors.initials: O
authors.lastname: Ramos-Lopez
authors.affiliation: Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco 44280, Mexico. apanduro@prodigy.net.mx.|Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico. apanduro@prodigy.net.mx.
authors.forename: Arturo
authors.initials: A
authors.lastname: Panduro
authors.affiliation: Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco 44280, Mexico. erikamtz27@yahoo.com.mx.|Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico. erikamtz27@yahoo.com.mx.
authors.forename: Erika
authors.initials: E
authors.lastname: Martinez-Lopez
authors.affiliation: Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco 44280, Mexico. soniamariaroman@hotmail.com.|Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico. soniamariaroman@hotmail.com.
authors.forename: Sonia
authors.initials: S
authors.lastname: Roman
mesh_terms: D000328:Adult; D000483:Alleles; D003430:Cross-Sectional Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005247:Feeding Behavior; D005260:Female; D005838:Genotype; D006801:Humans; D015228:Hypertriglyceridemia / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008800:Mexico; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D013649:Taste; D013650:Taste Buds / Q000378:metabolism*
chemical_list: D004040:Dietary Carbohydrates; D043562:Receptors, G-Protein-Coupled; C431926:taste receptors, type 1
keywords: Ile191Val polymorphism; TAS1R2 gene; West Mexico; carbohydrate intake; hypertriglyceridemia