title: Oligohydramnios and growth restriction do not portend worse prognosis in gastroschisis pregnancies.
abstract: OBJECTIVE
  Gastroschisis is a common abdominal wall defect. While most neonates have an excellent prognosis, complications do occur. Several risk factors for adverse neonatal outcomes have been identified, however, the impact of intrauterine growth restriction (IUGR) and oligohydramnios on neonatal morbidity and mortality has not been fully elucidated.
  
  
  METHODS
  In this retrospective cohort study of pregnancies complicated by gastroschisis at two tertiary-care centers during an eight-year period, maternal, fetal and neonatal data were analyzed to estimate the impact of IUGR and oligohydramnios upon neonatal outcomes. Adverse outcomes were defined as five-minute Apgar score <7, umbilical cord pH <7.12, neonatal sepsis, prolonged ventilator support, prolonged total parenteral nutrition, extended NICU stay, death and a composite of the above.
  
  
  RESULTS
  Among the 179 cases of gastroschisis, there were no differences in maternal demographics between cases with and without IUGR or oligohydramnios. Fetuses with oligohydramnios demonstrated a trend toward lower birthweight (p = 0.06). Small for gestational age infants showed a trend toward prolonged ventilator support (p = 0.06). Oligohydramnios and IUGR were otherwise not associated with adverse neonatal outcomes.
  
  
  CONCLUSIONS
  While risk factors for adverse neonatal outcomes have been identified in pregnancies complicated by gastroschisis, IUGR and oligohydramnios do not appear to be among them.
authors.affiliation: a UC Irvine Medical Center , Orange , CA , USA and.
authors.forename: Robert
authors.initials: R
authors.lastname: Johnston
authors.affiliation: b St. David's North Austin Medical Center Women's Center of Texas, Austin Maternal-Fetal Medicine , Austin , TX , USA.
authors.forename: Sina
authors.initials: S
authors.lastname: Haeri
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001724:Birth Weight; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis; D020139:Gastroschisis / Q000150:complications* / Q000401:mortality; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D000071074:Neonatal Sepsis / Q000209:etiology; D016104:Oligohydramnios / Q000175:diagnosis; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Abdominal wall defects; gastroschisis; growth restriction; neonatal outcome; oligohydramnios