title: Does defibrotide prophylaxis decrease the risk of acute graft versus host disease following allogeneic hematopoietic cell transplantation?
abstract: There is some preliminary evidence, that veno-occlusive disease prophylaxis with defibrotide (DF) may also have a role in decreasing risk of acute graft-versus-host disease (aGvHD) by preventing tissue damage. In this study, we aimed to investigate the role of DF prophylaxis on the development of aGvHD at D+180. One hundred ninety-five consecutive adult patients receiving allogeneic HCT were retrospectively evaluated in 3 groups: no DF, DF/post-HCT (DF D+1 to D+14) and DF/pre-HCT (DF for 14 days concurrently with conditioning). The total (p: 0.057) and grades III/IV (p: 0.051) aGvHD rates at D+180 were 46.5%, 40%, 25.5% and 15.5%, 11.2%, 0% in patients on no DF, DF/post-HCT and DF/pre-HCT. DF may have a role in decreasing incidence and severity of aGvHD, especially if used concurrently with conditioning regimen.
authors.affiliation: Ankara Oncology Education and Research Hospital, Hematology and Stem Cell Transplantation Clinic, Ankara, Turkey. Electronic address: emretekgunduz@yahoo.com.
authors.forename: Emre
authors.initials: E
authors.lastname: Tekgündüz
authors.affiliation: Ankara Oncology Education and Research Hospital, Hematology and Stem Cell Transplantation Clinic, Ankara, Turkey.
authors.forename: Ali Hakan
authors.initials: AH
authors.lastname: Kaya
authors.affiliation: Ankara University Medical Faculty, Department of Internal Medicine, Division of Hematology, Ankara, Turkey.
authors.forename: Sinem Civriz
authors.initials: SC
authors.lastname: Bozdağ
authors.affiliation: Ankara Oncology Education and Research Hospital, Hematology and Stem Cell Transplantation Clinic, Ankara, Turkey.
authors.forename: Şerife
authors.initials: Ş
authors.lastname: Koçubaba
authors.affiliation: Ankara Oncology Education and Research Hospital, Hematology and Stem Cell Transplantation Clinic, Ankara, Turkey.
authors.forename: Ömür
authors.initials: Ö
authors.lastname: Kayıkçı
authors.affiliation: Ankara Oncology Education and Research Hospital, Hematology and Stem Cell Transplantation Clinic, Ankara, Turkey.
authors.forename: Sinem
authors.initials: S
authors.lastname: Namdaroğlu
authors.affiliation: Ankara Oncology Education and Research Hospital, Hematology and Stem Cell Transplantation Clinic, Ankara, Turkey.
authors.forename: Bilge
authors.initials: B
authors.lastname: Uğur
authors.affiliation: Ankara Oncology Education and Research Hospital, Hematology and Stem Cell Transplantation Clinic, Ankara, Turkey.
authors.forename: Seval
authors.initials: S
authors.lastname: Akpınar
authors.affiliation: Ankara Oncology Education and Research Hospital, Hematology and Stem Cell Transplantation Clinic, Ankara, Turkey.
authors.forename: Hikmetullah
authors.initials: H
authors.lastname: Batgi
authors.affiliation: Ankara Oncology Education and Research Hospital, Hematology and Stem Cell Transplantation Clinic, Ankara, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Bekdemir
authors.affiliation: Yıldırım Beyazıt University Medical Faculty, Department of Internal Medicine, Division of Hematology, Ankara, Turkey.
authors.forename: Fevzi
authors.initials: F
authors.lastname: Altuntaş
mesh_terms: D000293:Adolescent; D000328:Adult; D001788:Blood Grouping and Crossmatching; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011089:Polydeoxyribonucleotides / Q000627:therapeutic use*; D014019:Tissue Donors; D014184:Transplantation, Homologous / Q000009:adverse effects; D055815:Young Adult
chemical_list: D011089:Polydeoxyribonucleotides; C036901:defibrotide
keywords: Acute GVHD; Acute graft-versus-host disease; Defibrotide; Prophylaxis