title: Comparison of Methods for Determining Aerobic Exercise Intensity Using Heart Rate in Acute Leukemia Patients Prior to Induction Chemotherapy.
abstract: Cardiopulmonary exercise testing (CPET), the gold standard of cardiopulmonary evaluation, is used to determine VO2 levels at different aerobic exercise training intensities; however, it may not be feasible to conduct CPET in all clinical settings.
  
  
  
  To compare the heart rate reserve (HRR) and percent of 220-age methods for prescribing cycle ergometry exercise intensity using heart rate (HR) against the HRs obtained during a CPET in adults undergoing treatment for acute leukemia (AL).
  
  
  
  In this exploratory study, part of a larger randomized controlled trial, 14 adults with AL completed CPET on a cycle ergometer with indirect calorimetry within 96 hr of admission to a cancer hospital to determine VO2peak and HR corresponding to low (40% VO2peak), moderate (60% VO2peak), and high (75% VO2peak) exercise intensities. Analyses of variance were used to compare estimated HR for each intensity level using the HRR and percent of 220-age methods with HR determined via VO2peak.
  
  
  
  HR corresponding to low-intensity exercise differed significantly across all three methods (p ≤ .05). No significant differences were observed between HR estimated via the percent of 220-age method and determined via VO2peak at moderate (100 ± 8 and 113 ± 24 bpm, p = .122) or high intensities (125 ± 10 and 123 ± 25 bpm, p = .994).
  
  
  
  In adults with AL, HR-based methods for defining aerobic exercise intensities should be used with caution. At low intensity, neither should be used, while at moderate and high intensities, the percent of 220-age equation might serve as an adequate substitute for CPET.
authors.affiliation: Department of Exercise and Sport Science, The University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Story
authors.affiliation: School of Nursing, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Ashley Leak
authors.initials: AL
authors.lastname: Bryant
authors.affiliation: Division of Hematology and Oncology, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Brett
authors.initials: B
authors.lastname: Phillips
authors.affiliation: Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Bailey
authors.affiliation: Department of Exercise and Sport Science, The University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Edgar W
authors.initials: EW
authors.lastname: Shields
authors.affiliation: Department of Exercise and Sport Science, The University of North Carolina at Chapel Hill, NC, USA claudio@email.unc.edu.
authors.forename: Claudio
authors.initials: C
authors.lastname: Battaglini
mesh_terms: D000208:Acute Disease / Q000628:therapy*; D000328:Adult; D000368:Aged; D015444:Exercise / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D060828:Induction Chemotherapy / Q000379:methods*; D007938:Leukemia / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*
keywords: acute leukemia; aerobic exercise intensity; chemotherapy; heart rate