title: Light Chain Deposition Disease After Kidney Transplantation With Long Graft Survival: Case Report.
abstract: Light Chain Deposition Disease (LCDD) is a monoclonal immunoglobulin deposition disease that commonly affects kidneys among other organs. It leads to end-stage renal disease and has a high disease recurrence rate after kidney transplantation. This has led some authors to advise against transplantation in view of the poor long-term graft and patient outcomes. Recent literature has shown improvement/stabilization of native kidney disease following the use of bortezomib. We present 2 cases of LCDD after transplantation with graft dysfunction. They were both treated with different therapeutic agents to induce remission. Because sustained remission was not achieved they received bortezomib following which they have experienced a prolonged period of stable renal function with no clinically detectable disease. These unique cases highlight the possibility to achieve long-term stable graft function and disease remission after renal transplantation for LCDD.
authors.affiliation: Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA. Electronic address: sarat-kuppachi@uiowa.edu.
authors.forename: S
authors.initials: S
authors.lastname: Kuppachi
authors.affiliation: Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
authors.forename: D
authors.initials: D
authors.lastname: Holanda
authors.affiliation: Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA; Department of Internal Medicine, VA Medical Center, Iowa City, Iowa, USA.
authors.forename: C P
authors.initials: CP
authors.lastname: Thomas
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000069286:Bortezomib / Q000627:therapeutic use; D006085:Graft Survival; D006801:Humans; D007147:Immunoglobulin Light Chains; D007668:Kidney / Q000503:physiopathology / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000188:drug therapy / Q000209:etiology*; D011183:Postoperative Complications; D012074:Remission Induction / Q000379:methods; D019737:Transplants / Q000503:physiopathology
chemical_list: D000970:Antineoplastic Agents; D007147:Immunoglobulin Light Chains; D000069286:Bortezomib