title: [The number of peripheral blood CD11c+ antigen presenting cells increases and their function strengthens in the patients with active pulmonary tuberculosis].
abstract: OBJECTIVE
  To detect the percentage of CD11c positive antigen presenting cells (CD11c(+) APCs) in peripheral blood from patients with active pulmonary tuberculosis (APT) and the levels of HLA-DR and CD86. Methods Fifty-two APT patients were enrolled in the study and 15 healthy volunteers served as controls. The frequencies of CD11c(+) APCs and the expressions of HLA-DR and CD86 in CD11c(+) APCs in the peripheral blood were determined by flow cytometry.
  
  
  RESULTS
  The percentage of CD11c(+) APCs in the peripheral blood in the patients with APT was much higher than that in the controls. Interestingly, CD11c(+) APCs frequency in post-treatment patients was even higher compared with that in the pre-treatment patients. Furthermore, both HLA-DR(+) CD11c(+) APC frequency and the mean fluorescence intensity (MFI) of HLA-DR in APT patients were higher than those in the controls. Similarly, the percentage of CD86(+) CD11c(+) APCs in the APT patients was also higher than that in the controls.
  
  
  CONCLUSIONS
  The increase of CD11c(+) APCs with high levels of HLA-DR and CD86 in APT patients suggests that the antigen presenting capacity of APCs is at a high level in APT patients.
authors.affiliation: Institute of Laboraratory Medicine, Guangdong Medical College, Dongguan 523808; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan 523808, China.
authors.forename: Yuanbin
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Institute of Laboraratory Medicine, Guangdong Medical College, Dongguan 523808; Xiaolan People's Hospital of Zhongshan City, Zhongshan 442000, China.
authors.forename: Wandang
authors.initials: W
authors.lastname: Wang
authors.affiliation: Sixth People's Hospital of Dongguan City, Dongguan 523122, China.
authors.forename: Ganbin
authors.initials: G
authors.lastname: Liu
authors.affiliation: Institute of Laboraratory Medicine, Guangdong Medical College, Dongguan 523808; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan 523808, China.
authors.forename: Junai
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Institute of Laboraratory Medicine, Guangdong Medical College, Dongguan 523808, China.
authors.forename: Yuchi
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Institute of Laboraratory Medicine, Guangdong Medical College, Dongguan 523808, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Sixth People's Hospital of Dongguan City, Dongguan 523122, China.
authors.forename: Lailong
authors.initials: L
authors.lastname: Yi
authors.affiliation: Institute of Laboraratory Medicine, Guangdong Medical College, Dongguan 523808; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan 523808, China. *Corresponding authors, E-mail: imxujunfa@163.com.
authors.forename: Junfa
authors.initials: J
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D017951:Antigen Presentation / Q000187:drug effects / Q000276:immunology; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D000995:Antitubercular Agents / Q000627:therapeutic use; D051940:B7-2 Antigen / Q000097:blood / Q000276:immunology; D039521:CD11c Antigen / Q000097:blood / Q000276:immunology*; D002452:Cell Count; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000097:blood / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000187:drug effects / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000276:immunology* / Q000502:physiology; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D051940:B7-2 Antigen; D039521:CD11c Antigen; D006684:HLA-DR Antigens