title: Acupuncture for chronic knee pain: a protocol for an updated systematic review.
abstract: BACKGROUND
  The aim of this study is to evaluate the efficacy and safety of acupuncture for patients with chronic knee pain.
  
  
  METHODS
  MEDLINE, EMBASE, CENTERAL, CINAHL and four Chinese medical databases will be searched from their inception to present. We will also manually retrieve eligible studies. Randomised controlled trials (RCTs) in which acupuncture is assessed as the sole treatment or as an adjunct treatment for chronic knee pain will be included. The primary outcome of our analysis is pain measured by the visual analogue scale (VAS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale or the 11-point numeric rating scale (NRS). The secondary outcomes will include the quality of life, measured by the 36-item Short-Form Health Survey (SF-36) and adverse events. Two researchers will conduct the study selection, data extraction and quality assessment independently. Any disagreement will be resolved through discussion with a third reviewer. The Cochrane risk-of-bias criteria and the Standards for Reporting Interventions in Controlled Trials of Acupuncture (STRICTA) checklist will be used to assess the methodological quality of the trials.
  
  
  RESULTS
  This systematic review will assess the current evidence on acupuncture therapy for chronic knee pain. It uses aggregated published data instead of individual patient data and does not require an ethical board review and approval. The findings will be published in a peer-reviewed journal and disseminated in conference presentations. It will provide the latest analysis of the currently available evidence for acupuncture treating chronic knee pain.
  
  
  BACKGROUND
  CRD42014015514.
authors.affiliation: Department of Acupuncture and Moxibustion, College of Acupuncture and Moxibustion, Heilongjiang University of Chinese Medicine, Harbin, China Department of Health Research and Policy, Stanford University, California, USA.
authors.forename: Qinhong
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Acupuncture and Moxibustion, College of Acupuncture and Moxibustion, Heilongjiang University of Chinese Medicine, Harbin, China.
authors.forename: Jinhuan
authors.initials: J
authors.lastname: Yue
authors.affiliation: Department of Acupuncture and Moxibustion, College of Acupuncture and Moxibustion, Heilongjiang University of Chinese Medicine, Harbin, China.
authors.forename: Zhongren
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Health Research and Policy, Stanford University, California, USA VA Palo Alto Cooperative Studies Program Coordinating Center, VA Palo Alto Health Care System, California, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Lu
mesh_terms: D015670:Acupuncture Therapy; D006801:Humans; D020370:Osteoarthritis, Knee / Q000150:complications*; D010146:Pain / Q000209:etiology*; D059408:Pain Management / Q000379:methods*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D000078202:Systematic Reviews as Topic; D016896:Treatment Outcome
keywords: COMPLEMENTARY MEDICINE; acupuncture; chronic knee pain; systematic review