title: 12T061A and 12T061C, two new julichrome family compounds, as radical scavengers from Streptomyces sp.
abstract: We identified two new radical scavengers, 12T061A (1, C19H20O7) and 12T061C (2, C20H22O7), from a culture of the Streptomyces sp. Spectroscopic analysis indicated that these compounds are new julichrome family compounds. Compounds 1 and 2 showed radical-scavenging activity with an ED50 of 370 μM and 18 μM, respectively. Moreover, 1 showed tumor cell growth suppressive activity in HepG2 cells, (IC50: 3.6 μM); however, no suppressive activity was shown in 2 (IC50: > 100 μM).
authors.affiliation: School of Food, Agricultural, and Environmental Sciences, Miyagi University.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Komoda
authors.forename: Naoko
authors.initials: N
authors.lastname: Saeki
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Koseki
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Kiyota
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification*; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D013057:Spectrum Analysis; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D016166:Free Radical Scavengers