title: Rare and transient anti-D antibody response in D(-) liver transplant recipients transfused with D(+) red blood cells.
abstract: A retrospective analysis was conducted on 20 D(-) liver transplant (LT) recipients transfused with D(+) RBCs perioperatively and screened for RBC antibodies between 2 and 6 months later. None developed anti-D detectable by the indirect antiglobulin test. Two patients produced weak anti-D that reacted only with papain-treated RBCs at 10 and 11 days without any sign of immune haemolysis. Antibodies became quickly undetectable. These data suggest an unusual pattern of alloimmunization in LT recipients with rapid, weak and transient antibody response and support the safety of transfusing D(+) RBCs in most of D(-) patients during LT surgery.
authors.affiliation: Etablissement Français du Sang Ile de France, Villejuif, France.
authors.forename: N
authors.initials: N
authors.lastname: Burin des Roziers
authors.affiliation: Etablissement Français du Sang Ile de France, Villejuif, France.
authors.forename: C
authors.initials: C
authors.lastname: Ibanez
authors.affiliation: Centre hépato-biliaire, Hôpital Paul Brousse, Villejuif, France.
authors.forename: D
authors.initials: D
authors.lastname: Samuel
authors.affiliation: Service d'hépatologie et réanimation hépato-digestive, Hôpital Beaujon, Clichy, France.
authors.forename: C
authors.initials: C
authors.lastname: Francoz
authors.affiliation: Etablissement Français du Sang Ile de France, Villejuif, France.
authors.forename: S
authors.initials: S
authors.lastname: Idri
authors.affiliation: Etablissement Français du Sang Ile de France, Villejuif, France.
authors.forename: A
authors.initials: A
authors.lastname: François
authors.affiliation: Etablissement Français du Sang Ile de France, Villejuif, France.
authors.forename: R
authors.initials: R
authors.lastname: Mortelecque
authors.affiliation: Etablissement Français du Sang Ile de France, Villejuif, France.|Inserm U955-Equipe 2: Transfusion et maladies du globule rouge, Laboratoire d'Excellence, GRex, Institut Mondor, Créteil, France.
authors.forename: P
authors.initials: P
authors.lastname: Bierling
authors.affiliation: Etablissement Français du Sang Ile de France, Villejuif, France.|Inserm U955-Equipe 2: Transfusion et maladies du globule rouge, Laboratoire d'Excellence, GRex, Institut Mondor, Créteil, France.
authors.forename: F
authors.initials: F
authors.lastname: Pirenne
mesh_terms: D000328:Adult; D001803:Blood Transfusion; D003298:Coombs Test; D004912:Erythrocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D005260:Female; D006461:Hemolysis; D006801:Humans; D007518:Isoantibodies / Q000097:blood; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D010206:Papain / Q000378:metabolism; D012189:Retrospective Studies; D018029:Rho(D) Immune Globulin / Q000097:blood* / Q000276:immunology; D055815:Young Adult
chemical_list: D007518:Isoantibodies; C061961:RHO(D) antibody; D018029:Rho(D) Immune Globulin; D010206:Papain
keywords: Rh-Hr blood group system; antibody formation; blood transfusion; haemolysis; immunosuppression; liver transplantation