title: Feasibility of 320-row area detector CT coronary angiography using 40 mL of contrast material: assessment of image quality and diagnostic accuracy.
abstract: OBJECTIVE
  To assess the image quality and diagnostic accuracy of 320-row area detector CT (320-ADCT) coronary angiography using 40 mL of contrast material in comparison with 60-mL protocol.
  
  
  METHODS
  This retrospective study included 183 patients who underwent 320-ADCT coronary angiography using 40 mL of contrast and additional 183 sex- and body mass index-matched patients using 60 mL of contrast constituting the control group. Both groups used the same 5-mL/sec injection rate. Quantitative image quality measurements and diagnostic accuracies were calculated and compared.
  
  
  RESULTS
  Mean attenuation and contrast-to-noise ratio (CNR) at the aorta and all coronary arteries were lower in the 40-mL group than in the 60-mL group (all, p < 0.05), except for the CNR at proximal coronary arteries at 100 kVp (p = 0.073). However, the proportion of coronary segments with vessel attenuation >250 HU was not different between groups (all, p > 0.05), except for distal coronary arteries at 80 kVp (p = 0.001). Furthermore, there were no differences in per-patient and per-segment diagnostic accuracies between the groups (all, p > 0.05).
  
  
  CONCLUSIONS
  320-ADCT coronary angiography using 40 mL of contrast showed image quality and diagnostic accuracy comparable to the 60-mL protocol, demonstrating the clinical feasibility of lowering the risk of contrast-induced nephropathy through contrast volume reduction.
  
  
  CONCLUSIONS
  • 320-ADCT might enable reduction of contrast material volume. • A 40-mL contrast protocol for 320-ADCT provided acceptable image quality. • A 40-mL contrast protocol for 320-ADCT demonstrated sufficient diagnostic accuracy.
authors.affiliation: Department of Radiology, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Korea.
authors.forename: Rihyeon
authors.initials: R
authors.lastname: Kim
authors.affiliation: Department of Radiology, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Korea. iameuna1@gmail.com.
authors.forename: Eun-Ah
authors.initials: EA
authors.lastname: Park
authors.affiliation: Department of Radiology, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Korea.
authors.forename: Whal
authors.initials: W
authors.lastname: Lee
authors.affiliation: Department of Radiology, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Korea.
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Chung
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage*; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000175:diagnosis*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: 320-row area detector CT; Computed tomography coronary angiography; Contrast material; Contrast-induced nephropathy; Diagnostic accuracy