title: Anterograde Degeneration of the Nigrostriatal Pathway Visualized by 123I-FP-CIT SPECT in a Patient With Artery of Percheron Infarction.
abstract: I-FP-CIT SPECT is widely used for diagnosis in patients with parkinsonism. Vascular parkinsonism usually has nonspecific findings from normal uptake to radiotracer decrease in the infarcted region. Infarction of the substantia nigra has been reported as a rare cause of vascular parkinsonism. We present a case of artery of Percheron infarction involving the substantia nigra unilaterally with ipsilateral reduction of striatal uptake on I-FP-CIT SPECT, suggesting anterograde degeneration of the nigrostriatal pathway. Infarction of the substantia nigra should be considered in cases of decreased striatal uptake with marked laterality on I-FP-CIT SPECT.
authors.affiliation: From the *Department of Diagnostic Radiology, Medical Hospital, Tokyo Medical and Dental University, Tokyo; †Department of Internal Medicine, Chiba-Nishi General Hospital, Chiba; and ‡Department of Radiology, St Luke's International Hospital, Tokyo, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Nakadate
authors.forename: Norikazu
authors.initials: N
authors.lastname: Miyamoto
authors.forename: Jay
authors.initials: J
authors.lastname: Starkey
authors.forename: Akira
authors.initials: A
authors.lastname: Toriihara
authors.forename: Ukihide
authors.initials: U
authors.lastname: Tateishi
mesh_terms: D000369:Aged, 80 and over; D063405:Anatomic Variation; D001158:Arteries; D020520:Brain Infarction / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D020762:Infarction, Posterior Cerebral Artery / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D017072:Neostriatum / Q000000981:diagnostic imaging* / Q000378:metabolism; D009434:Neural Pathways / Q000000981:diagnostic imaging; D019636:Neurodegenerative Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D020769:Posterior Cerebral Artery / Q000002:abnormalities*; D019275:Radiopharmaceuticals; D013378:Substantia Nigra / Q000000981:diagnostic imaging* / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
chemical_list: D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane