title: Causes of prolonged jaundice in infancy: 3-year experience in a tertiary paediatric centre.
abstract: Although prolonged jaundice (PJ) commonly occurs in infancy, there is not yet agreement as to the appropriate extent of investigations, particularly in otherwise well children. Significant pathologies may present with PJ in this age group and need to be considered.
  
  
  OBJECTIVE
  The aim of this retrospective study was to ascertain the causes of PJ in infants referred to a single tertiary paediatric centre.
  
  
  METHODS
  Infants referred with PJ over a 3-year period were identified. Clinical documentation, electronic notes and results of investigations performed prior to and after referral were reviewed.
  
  
  RESULTS
  One hundred and sixty-seven infants with PJ were seen. Fifty-eight percent were over 28 days of age. Four patients had conjugated hyperbilirubinaemia. Eighteen percent of patients were found to have a specific medical diagnosis causing or contributing to PJ, almost half of whom had normal clinical examination. The single most common pathological cause for PJ was hypothyroidism found in six patients.
  
  
  CONCLUSIONS
  This study demonstrates that normal clinical examination and exclusion of conjugated hyperbilirubinaemia are insufficient to exclude pathological causes of PJ. Overall, these children were referred late. Guidelines, in conjunction with education initiatives, are required to optimise the management of prolonged jaundice in infancy.
authors.affiliation: Paediatric Outpatient Department, Christchurch Hospital, 2 Riccarton Avenue, Christchurch, 4710, New Zealand. drmargaretandre@gmail.com.
authors.forename: Margaret
authors.initials: M
authors.lastname: Andre
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Day
mesh_terms: D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D006933:Hyperbilirubinemia, Hereditary / Q000150:complications / Q000175:diagnosis; D007037:Hypothyroidism / Q000150:complications / Q000175:diagnosis; D007223:Infant; D007231:Infant, Newborn; D007565:Jaundice / Q000209:etiology*; D008297:Male; D012189:Retrospective Studies; D062606:Tertiary Care Centers