title: Diagnostic potential of polarized surface enhanced Raman spectroscopy technology for colorectal cancer detection.
abstract: The purpose of this study was to develop a more powerful blood analysis method based on polarized surface enhanced Raman spectroscopy (SERS) technology for non-invasive and sensitive colorectal cancer (CRC) detection. The efficiency of different polarized scattering signals (non-polarization, parallel polarization and perpendicular polarization) on blood serum SERS was explored for the first time. Results demonstrated that polarized SERS was more sensitive to explore distinctive spectral differences between cancer and normal groups. And higher diagnostic accuracy of 91.6% could be achieved using polarized SERS integrated with PCA-LDA for classification of the two serum groups in comparison to conventional SERS technology. This exploratory study demonstrated that the nanobiosensor based on polarized SERS technique in conjunction with PCA-LDA provided a novel strategy for blood SERS analysis, and had the potential as a clinical complement for CRC screening.
authors.forename: Duo
authors.initials: D
authors.lastname: Lin
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
authors.forename: Sufang
authors.initials: S
authors.lastname: Qiu
authors.forename: Shangyuan
authors.initials: S
authors.lastname: Feng
authors.forename: Guannan
authors.initials: G
authors.lastname: Chen
authors.forename: Rong
authors.initials: R
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D001800:Blood Specimen Collection; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D016002:Discriminant Analysis; D006801:Humans; D008875:Middle Aged; D025341:Principal Component Analysis; D011336:Probability; D013059:Spectrum Analysis, Raman / Q000379:methods*; D014732:Vibration