title: Chemometric analysis of the interactions among different parameters describing health conditions, breast cancer risk and fatty acids profile in serum of rats supplemented with conjugated linoleic acids.
abstract: We investigated how different doses of conjugated linoleic acids applied for various periods of time influence breast cancer risk and fatty acids profile in serum of rats treated or not with 7,12-dimethylbenz[a]anthracene (DMBA). We also search for interactions among parameters describing health conditions and cancer risk. Animals were divided into 18 groups with different diet modifications (vegetable oil, 1.0%, 2.0% additions of CLA) and different periods of supplementation. In groups treated with DMBA mammary adenocarcinomas appeared. Due to the complexity of experiment apart from statistical analysis a chemometric tool-Partial Least Square method was applied. Analysis of pairs of correlated parameters allowed to identify some regularities concerning the relationships between fatty acid profiles and clinical features of animals. Fatty acids profile was the result of prolonged exposure to high dose of CLA and DMBA administration. These two factors underlined the differences in fatty acids profiles among clusters of animals.
authors.affiliation: Department of Bromatology, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland. Electronic address: agnieszka.bialek@wum.edu.pl.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Białek
authors.affiliation: Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland; H. Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow, Poland. Electronic address: Pawel.Zagrodzki@ifj.edu.pl.
authors.forename: Paweł
authors.initials: P
authors.lastname: Zagrodzki
authors.affiliation: Department of Bromatology, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland. Electronic address: andrzej.tokarz@wum.edu.pl.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Tokarz
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000009:adverse effects*; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D016018:Least-Squares Analysis; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage* / Q000494:pharmacology; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000378:metabolism; D051381:Rats; D012307:Risk Factors
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D044243:Linoleic Acids, Conjugated; D015127:9,10-Dimethyl-1,2-benzanthracene
keywords: Breast cancer; Cluster analysis; Fatty acids; PARTIAL Least Square