title: Differential Expression of microRNAs and their Regulatory Networks in Skin Tissue of Liaoning Cashmere Goat during Hair Follicle Cycles.
abstract: MicroRNAs (miRNAs) are endogenous small noncoding RNA molecules that negatively regulate gene expression. Herein, we investigated a selective number of miRNAs for their expression in skin tissue of Liaoning Cashmere goat during hair follicle cycles, and their intracellular regulatory networks were constructed based on bioinformatics analysis. The relative expression of six miRNAs (mir-103-3p, -15b-5p, 17-5p, -200b, -25-3p, and -30c-5p) at anagen phase is significantly higher than that at catagen and/or telogen phases. In comparison to anagen, the relative expression of seven miRNAs (mir-148a-3p, -199a-3p, -199a-5p, -24-3p, -30a-5p, -30e-5p, and -29a-3p) was revealed to be significantly up-regulated at catagen and/or telogen stages. The network analyses of miRNAs indicated those miRNAs investigated might be directly or indirectly involved in several signaling pathways through their target genes. These results provided a foundation for further insight into the roles of these miRNAs in skin tissue of Liaoning Cashmere goat during hair follicle cycles.
authors.affiliation: a College of Animal Science and Veterinary Medicine , Shenyang Agricultural University , Shenyang , China.
authors.forename: Wen L
authors.initials: WL
authors.lastname: Bai
authors.affiliation: a College of Animal Science and Veterinary Medicine , Shenyang Agricultural University , Shenyang , China.
authors.forename: Yun L
authors.initials: YL
authors.lastname: Dang
authors.affiliation: a College of Animal Science and Veterinary Medicine , Shenyang Agricultural University , Shenyang , China.
authors.forename: Rong H
authors.initials: RH
authors.lastname: Yin
authors.affiliation: a College of Animal Science and Veterinary Medicine , Shenyang Agricultural University , Shenyang , China.
authors.forename: Wu Q
authors.initials: WQ
authors.lastname: Jiang
authors.affiliation: a College of Animal Science and Veterinary Medicine , Shenyang Agricultural University , Shenyang , China.
authors.forename: Ze Y
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: a College of Animal Science and Veterinary Medicine , Shenyang Agricultural University , Shenyang , China.
authors.forename: Yu B
authors.initials: YB
authors.lastname: Zhu
authors.affiliation: b Institute of Animal Husbandry Science of Liaoning Province , Liaoyang , China.
authors.forename: Shi Q
authors.initials: SQ
authors.lastname: Wang
authors.affiliation: a College of Animal Science and Veterinary Medicine , Shenyang Agricultural University , Shenyang , China.
authors.forename: Ying Y
authors.initials: YY
authors.lastname: Zhao
authors.affiliation: a College of Animal Science and Veterinary Medicine , Shenyang Agricultural University , Shenyang , China.
authors.forename: Liang
authors.initials: L
authors.lastname: Deng
authors.affiliation: a College of Animal Science and Veterinary Medicine , Shenyang Agricultural University , Shenyang , China.
authors.forename: Guang B
authors.initials: GB
authors.lastname: Luo
authors.affiliation: b Institute of Animal Husbandry Science of Liaoning Province , Liaoyang , China.
authors.forename: Shu H
authors.initials: SH
authors.lastname: Yang
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006041:Goats / Q000235:genetics* / Q000378:metabolism; D018859:Hair Follicle / Q000378:metabolism*; D035683:MicroRNAs / Q000032:analysis / Q000235:genetics* / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
keywords: Hair follicle cycles; liaoning cashmere goat; microRNA expression; regulatory networks; skin tissue