title: Metal ion triggers for reversible switching of DNA polymerase.
abstract: We herein develop a new strategy that modulates DNA polymerase activity in a reversible and switchable manner by using the novel interactions between DNA bases and metal ions (T-Hg(2+)-T and C-Ag(+)-C) inside a DNA aptamer capable of inhibiting DNA polymerase.
authors.affiliation: Department of Chemical and Biomolecular Engineering (BK 21+ program), KAIST, Daejeon 305-338, Republic of Korea. hgpark@kaist.ac.kr.
authors.forename: Ki Soo
authors.initials: KS
authors.lastname: Park
authors.forename: Chang Yeol
authors.initials: CY
authors.lastname: Lee
authors.forename: Hyun Gyu
authors.initials: HG
authors.lastname: Park
mesh_terms: D004259:DNA-Directed DNA Polymerase / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*
chemical_list: D008670:Metals; D004259:DNA-Directed DNA Polymerase