title: The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle: Pharmacological Analysis.
abstract: The contractile effect of AITC (300 μM) on human jejunal longitudinal strips was inhibited by the TRPA1 antagonist HC 030031 and atropine or scopolamine, but was insensitive to tetrodotoxin, purinoceptor antagonists or capsaicin desensitization. It is concluded that TRPA1 activation stimulates a cholinergic mechanism in a tetrodotoxin-resistant manner.
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Pecs, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Sandor
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Pecs, Hungary.
authors.forename: Andras
authors.initials: A
authors.lastname: Dekany
authors.affiliation: Department of Surgery, University Medical School of Pecs, Pecs, Hungary.
authors.forename: Dezsö
authors.initials: D
authors.lastname: Kelemen
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Pecs, Hungary.|Department of Pharmacognosy, University Medical School of Pecs, Pecs, Hungary.
authors.forename: Timea
authors.initials: T
authors.lastname: Bencsik
authors.affiliation: Department of Surgery, University Medical School of Pecs, Pecs, Hungary.
authors.forename: Robert
authors.initials: R
authors.lastname: Papp
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Pecs, Hungary.
authors.forename: Lorand
authors.initials: L
authors.lastname: Bartho
mesh_terms: D000083:Acetanilides / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D015220:Calcium Channels / Q000235:genetics* / Q000378:metabolism; D002211:Capsaicin / Q000494:pharmacology; D018678:Cholinergic Agents / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D017879:Isothiocyanates / Q000494:pharmacology*; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects*; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D011687:Purines / Q000494:pharmacology; D011983:Receptors, Purinergic / Q000187:drug effects / Q000378:metabolism; D012601:Scopolamine / Q000494:pharmacology; D000074025:TRPA1 Cation Channel; D013779:Tetrodotoxin / Q000494:pharmacology; D050051:Transient Receptor Potential Channels / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism
chemical_list: C552888:2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide; D000083:Acetanilides; D015220:Calcium Channels; D018678:Cholinergic Agents; D017879:Isothiocyanates; D009419:Nerve Tissue Proteins; D011687:Purines; D011983:Receptors, Purinergic; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050051:Transient Receptor Potential Channels; D013779:Tetrodotoxin; D001285:Atropine; C004471:allyl isothiocyanate; D012601:Scopolamine; D002211:Capsaicin