title: Aminoquinoline-assisted vinylic C-H arylation of unsubstituted acrylamide for the selective synthesis of Z olefins.
abstract: A method for Pd-catalyzed, aminoquinoline-directed arylation of vinylic C-H bonds with aryl iodides has been developed. This reaction represents a rare example of Pd-catalyzed vinylic C-H functionalization of unsubstituted acrylamide, allowing for the highly regio- and stereoselective preparation of Z-olefins. High tolerance to functional groups is observed with good yields and excellent selectivity. It offers a complementary synthetic method to traditional pathways for Z-olefins.
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China. chaojiang@njust.edu.cn.
authors.forename: Xiuzhi
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China. chaojiang@njust.edu.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China. chaojiang@njust.edu.cn.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201, USA. fxue@rx.umaryland.edu.
authors.forename: Fengtian
authors.initials: F
authors.lastname: Xue
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China. chaojiang@njust.edu.cn.
authors.forename: Chao
authors.initials: C
authors.lastname: Jiang