title: The Lymphocyte-Monocyte Ratio Predicts Patient Survival and Aggressiveness of Ovarian Cancer.
abstract: OBJECTIVE
  To measure the prognostic value of the lymphocyte-monocyte ratio (LMR) in patients with epithelial ovarian cancer (EOC).
  
  
  METHODS
  We retrospectively examined the LMR as a prognosticator in a cohort of 234 patients with EOC who underwent surgical resection. Patients were categorized into two different groups based on the LMR (LMR-low and LMR-high) using cut-off values determined by receiver operating characteristic (ROC) curve analysis. The objective of the study was to assess the effect of the LMR on progression-free survival (PFS) and overall survival (OS), and to validate the LMR as an independent predictor of survival.
  
  
  RESULTS
  Using the data collected from the whole cohort, the optimized LMR cut-off value selected on the ROC curve was 2.07 for both PFS and OS. The LMR-low and LMR-high groups included 48 (20.5%) and 186 patients (79.5%), respectively. The 5-year PFS rates in the LMR-low and LMR-high groups were 40.0 and 62.5% (P < 0.0001), respectively, and the 5-year OS rates in these two groups were 42.2 and 67.2% (P < 0.0001), respectively. On multivariate analysis, we identified age, International Federation of Gynecology and Obstetrics (FIGO) stage, and cancer antigen 125 levels to be the strongest valuable prognostic factors affecting PFS (P = 0.0421, P = 0.0012, and P = 0.0313, respectively) and age, FIGO stage, and the LMR as the most valuable prognostic factors predicting OS (P = 0.0064, P = 0.0029, and P = 0.0293, respectively). Conclusion : The LMR is an independent prognostic factor affecting the survival of patients with EOC.
authors.affiliation: 1. Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea;
authors.forename: Wan Kyu
authors.initials: WK
authors.lastname: Eo
authors.affiliation: 1. Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea;
authors.forename: Hye Jung
authors.initials: HJ
authors.lastname: Chang
authors.affiliation: 2. Department of Obstetrics and Gynecology, Keimyung University, School of Medicine, Daegu, Korea;
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Kwon
authors.affiliation: 3. Department of Obstetrics and Gynecology, Catholic University of Daegu, School of Medicine, Daegu, Korea;
authors.forename: Suk Bong
authors.initials: SB
authors.lastname: Koh
authors.affiliation: 4. Department of Pathology, College of Medicine, Kosin University, Busan, Korea;
authors.forename: Young Ok
authors.initials: YO
authors.lastname: Kim
authors.affiliation: 5. Department of Obstetrics and Gynecology, College of Medicine, Inje University, Busan, Korea;
authors.forename: Yong Il
authors.initials: YI
authors.lastname: Ji
authors.affiliation: 6. Department of Obstetrics and Gynecology, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea;
authors.forename: Hong-Bae
authors.initials: HB
authors.lastname: Kim
authors.affiliation: 7. Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea;
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: 8. Department of Obstetrics and Gynecology, Pusan National University School of Medicine; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea;
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Suh
authors.affiliation: 8. Department of Obstetrics and Gynecology, Pusan National University School of Medicine; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea;
authors.forename: Ki Hyung
authors.initials: KH
authors.lastname: Kim
authors.affiliation: 9. Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea;
authors.forename: Ik Jin
authors.initials: IJ
authors.lastname: Chang
authors.affiliation: 9. Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea;
authors.forename: Heung Yeol
authors.initials: HY
authors.lastname: Kim
authors.affiliation: 10. Department of Plastic and Reconstructive Surgery, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Suk Choo
authors.initials: SC
authors.lastname: Chang
keywords: Lymphocytes; Monocytes; Ovarian neoplasms