title: Rubiaceae-Type Cyclopeptides from Galianthe thalictroides.
abstract: Two Rubiaceae-type cyclopeptides, 6-O-methylbouvardin (1) and the new cyclopeptide 5β-hydroxy-RA-III (2), were isolated from the roots of Galianthe thalictroides. Employing the sulforhodamine B assay, compounds 1 and 2 were tested in vitro against three cancer cell lines--786-0 (kidney carcinoma), PC-3 (prostate carcinoma), and HT-29 (colon carcinoma)--and showed GI50 values ranging from 0.06 to 1.80 μg mL(-1). This is the first report on the isolation of Rubiaceae-type cyclopeptides from a genus other than Rubia or Bouvardia.
authors.affiliation: Instituto de Química, Universidade Federal de Mato Grosso do Sul , Campo Grande, MS 79074-460, Brazil.
authors.forename: Patrícia O
authors.initials: PO
authors.lastname: Figueiredo
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul , Campo Grande, MS 79070-900, Brazil.
authors.forename: Maria de Fatima C
authors.initials: Mde F
authors.lastname: Matos
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul , Campo Grande, MS 79070-900, Brazil.
authors.forename: Renata T
authors.initials: RT
authors.lastname: Perdomo
authors.affiliation: Instituto de Química, Universidade Federal de Mato Grosso do Sul , Campo Grande, MS 79074-460, Brazil.
authors.forename: Wilson H
authors.initials: WH
authors.lastname: Kato
authors.affiliation: Instituto de Química, Universidade Federal de Mato Grosso do Sul , Campo Grande, MS 79074-460, Brazil.
authors.forename: Marcos Vinícius G O
authors.initials: MV
authors.lastname: Barros
authors.affiliation: Instituto de Química, Universidade Federal de Mato Grosso do Sul , Campo Grande, MS 79074-460, Brazil.
authors.forename: Fernanda R
authors.initials: FR
authors.lastname: Garcez
authors.affiliation: Instituto de Química, Universidade Federal de Mato Grosso do Sul , Campo Grande, MS 79074-460, Brazil.
authors.forename: Walmir S
authors.initials: WS
authors.lastname: Garcez
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: C000610615:5beta-hydroxy-RA-III; D000972:Antineoplastic Agents, Phytogenic; D010456:Peptides, Cyclic; D010936:Plant Extracts; C045633:6-O-methylbouvardin