title: Status Epilepticus.
abstract: Although the majority of seizures are brief and cause no long-term consequences, a subset is sufficiently prolonged that long-term consequences can result. These very prolonged seizures are termed "status epilepticus" (SE) and are considered a neurological emergency. The clinical presentation of SE can be diverse. SE can occur at any age but most commonly occurs in the very young and the very old. There are numerous studies on SE in animals in which the pathophysiology, medication responses, and pathology can be rigorously studied in a controlled fashion. Human data are consistent with the animal data. In particular, febrile status epilepticus (FSE), a form of SE common in young children, is associated with injury to the hippocampus and subsequent temporal lobe epilepsy (TLE) in both animals and humans.
authors.affiliation: Virginia Commonwealth University, Richmond, Virginia 23298-0211.
authors.forename: Syndi
authors.initials: S
authors.lastname: Seinfeld
authors.affiliation: University of Virginia, Charlottesville, Virginia 22908.
authors.forename: Howard P
authors.initials: HP
authors.lastname: Goodkin
authors.affiliation: Comprehensive Epilepsy Management Center, Montefiore Medical Center, Albert Einstein College of Medicine, New York, New York 10467.
authors.forename: Shlomo
authors.initials: S
authors.lastname: Shinnar
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe / Q000209:etiology; D006624:Hippocampus / Q000293:injuries; D006801:Humans; D012640:Seizures / Q000503:physiopathology*; D013226:Status Epilepticus / Q000453:epidemiology / Q000209:etiology / Q000628:therapy