title: Liquid Ventilation for the Induction of Ultrafast Hypothermia in Resuscitation Sciences: A Review.
abstract: Liquid ventilation was initially proposed for lung lavage and respiratory support. More recently, it was also investigated as an experimental strategy for ultrafast cooling or organ preservation during ischemic disorders. The goal of this article is to identify and review the studies that investigated liquid ventilation in the field of resuscitation sciences. An exhaustive analysis of the literature was performed using the Medline database up to 15th September 2015. Articles were selected according to their relevance. All articles focusing on respiratory support were excluded. On the basis of 76 retrieved studies from the Medline database, 29 were included in this review. All studies were experimental reports and most of them investigated the cooling properties of liquid ventilation in animal models of experimental cardiac arrest or coronary artery occlusion in rabbits or pigs. Animal studies demonstrated a wide range of potential applications of total liquid ventilation in resuscitation sciences. This strategy is able to provide ultrafast cooling, independent of the body weight. In animal models of cardiopulmonary resuscitation, it was shown to provide potent benefits widely linked to cooling rapidity.
authors.affiliation: 1 Inserm , Unité 955, Equipe 03, Créteil, France .|2 Université Paris Est , UMR_S955, DHU A-TVB, UPEC, Créteil, France .|3 Université Paris Est , École Nationale Vétérinaire d'Alfort, Maisons-Alfort Cedex, France .
authors.forename: Matthias
authors.initials: M
authors.lastname: Kohlhauer
authors.affiliation: 1 Inserm , Unité 955, Equipe 03, Créteil, France .|2 Université Paris Est , UMR_S955, DHU A-TVB, UPEC, Créteil, France .|3 Université Paris Est , École Nationale Vétérinaire d'Alfort, Maisons-Alfort Cedex, France .
authors.forename: Alain
authors.initials: A
authors.lastname: Berdeaux
authors.affiliation: 4 Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa Hospitals and Clinics , Iowa City, Iowa.
authors.forename: Richard E
authors.initials: RE
authors.lastname: Kerber
authors.affiliation: 5 Department of Mechanical Engineering, Université de Sherbrooke , Sherbrooke, Canada .
authors.forename: Philippe
authors.initials: P
authors.lastname: Micheau
authors.affiliation: 1 Inserm , Unité 955, Equipe 03, Créteil, France .|2 Université Paris Est , UMR_S955, DHU A-TVB, UPEC, Créteil, France .|3 Université Paris Est , École Nationale Vétérinaire d'Alfort, Maisons-Alfort Cedex, France .
authors.forename: Bijan
authors.initials: B
authors.lastname: Ghaleh
authors.affiliation: 1 Inserm , Unité 955, Equipe 03, Créteil, France .|2 Université Paris Est , UMR_S955, DHU A-TVB, UPEC, Créteil, France .|3 Université Paris Est , École Nationale Vétérinaire d'Alfort, Maisons-Alfort Cedex, France .
authors.forename: Renaud
authors.initials: R
authors.lastname: Tissier
mesh_terms: D000818:Animals; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D004195:Disease Models, Animal; D006323:Heart Arrest / Q000628:therapy*; D007036:Hypothermia, Induced / Q000379:methods*; D021061:Liquid Ventilation / Q000379:methods*