title: Further evidence for heredity of pterygium.
abstract: Epidemiological reports strongly indicate that pterygium is an ophthalmoheliosis: a sun-related eye disease. Familial occurrence of pterygium is rare but supports the concept that heredity may predispose the conjunctiva to react abnormally to atmospheric-environmental stimuli. We describe a two generation Caucasian family of five members from the United Kingdom, four of whom developed pterygia in early adulthood with autosomal dominant inheritance. The present report confirms the significance of heredity in the pathogenesis of pterygium. Understanding the genetic basis of pterygium pathogenesis is clinically relevant, particularly in the management of patients who develop recurrent and aggressive pterygia at younger ages.
authors.affiliation: a Department of Corneal and External Eye Diseases, St. Paul's Eye Unit , Royal Liverpool University Hospital , Liverpool , UK.
authors.forename: Vito
authors.initials: V
authors.lastname: Romano
authors.affiliation: a Department of Corneal and External Eye Diseases, St. Paul's Eye Unit , Royal Liverpool University Hospital , Liverpool , UK.|b Department of Ophthalmology , Medical University of Innsbruck , Innsbruck , Austria.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Steger
authors.affiliation: a Department of Corneal and External Eye Diseases, St. Paul's Eye Unit , Royal Liverpool University Hospital , Liverpool , UK.
authors.forename: Adriana
authors.initials: A
authors.lastname: Kovacova
authors.affiliation: a Department of Corneal and External Eye Diseases, St. Paul's Eye Unit , Royal Liverpool University Hospital , Liverpool , UK.|c Department of Eye and Vision Science , Institute of Ageing and Chronic Disease, University of Liverpool , Liverpool , UK.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kaye
authors.affiliation: a Department of Corneal and External Eye Diseases, St. Paul's Eye Unit , Royal Liverpool University Hospital , Liverpool , UK.|c Department of Eye and Vision Science , Institute of Ageing and Chronic Disease, University of Liverpool , Liverpool , UK.
authors.forename: Colin E
authors.initials: CE
authors.lastname: Willoughby
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D040941:Heredity; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011625:Pterygium / Q000175:diagnosis / Q000235:genetics*; D006113:United Kingdom; D014792:Visual Acuity; D044465:White People / Q000235:genetics
keywords: Familial pterygium; heredity; inheritance; pterygium