title: The Role of Ursodeoxycholic Acid in Acute Viral Hepatitis: an Evidence-based Case Report.
abstract: OBJECTIVE
  to review the role of ursodeoxycholic acid in acute viral hepatitis.
  
  
  METHODS
  following literature searching according to the clinical question on Pubmed and Cochrane Library. After filtered with our inclusion and exclusion criteria, one meta-analysis and two randomized clinical trials are obtained. Through critical appraisal, it was concluded that the articles meet the criteria for validity and relevance.
  
  
  RESULTS
  the article found that there is a positive effect of ursodeoxycholic acid on the activity of serum transaminases and cholestasis indexes. However, there is insufficient evidence to support or to refute effects of ursodeoxycholic acid on disease's course as well as the viral load.
  
  
  CONCLUSIONS
  better method of clinical trials are needed to obtain a valid and applicable result for daily practice.
authors.affiliation: Department of Internal Medicine. Faculty of Medicine, Universitas Pelita Harapan, Banten, Indonesia.
authors.forename: Indra
authors.initials: I
authors.lastname: Wijaya
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D006518:Hepatitis Viruses / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid