title: Comparison of the amyloid pore forming properties of rat and human Alzheimer's beta-amyloid peptide 1-42: Calcium imaging data.
abstract: The data here consists of calcium imaging of human neuroblastoma SH-SY5Y cells treated with the calcium-sensitive dye Fluo-4AM and then incubated with nanomolar concentrations of either human or rat Alzheimer's β-amyloid peptide Aβ1-42. These data are both of a qualitative (fluorescence micrographs) and semi-quantitative nature (estimation of intracellular calcium concentrations of cells probed by Aβ1-42 peptides vs. control untreated cells). Since rat Aβ1-42 differs from its human counterpart at only three amino acid positions, this comparative study is a good assessment of the specificity of the amyloid pore forming assay. The interpretation of this dataset is presented in the accompanying study "Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides" [1].
authors.affiliation: Aix-Marseille Université, PPSN-EA4674, Faculté des Sciences, Marseille, France.
authors.forename: Coralie
authors.initials: C
authors.lastname: Di Scala
authors.affiliation: Aix-Marseille Université, PPSN-EA4674, Faculté des Sciences, Marseille, France.
authors.forename: Nouara
authors.initials: N
authors.lastname: Yahi
authors.affiliation: Aix-Marseille Université, PPSN-EA4674, Faculté des Sciences, Marseille, France.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Flores
authors.affiliation: Aix-Marseille Université, PPSN-EA4674, Faculté des Sciences, Marseille, France.
authors.forename: Sonia
authors.initials: S
authors.lastname: Boutemeur
authors.affiliation: INSERM, INMED, Parc Scientifique de Luminy, 13009 Marseille, France.
authors.forename: Nazim
authors.initials: N
authors.lastname: Kourdougli
authors.affiliation: Aix-Marseille Université, PPSN-EA4674, Faculté des Sciences, Marseille, France.
authors.forename: Henri
authors.initials: H
authors.lastname: Chahinian
authors.affiliation: Aix-Marseille Université, PPSN-EA4674, Faculté des Sciences, Marseille, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Fantini