title: The Breast-Thyroid Cancer Link: A Systematic Review and Meta-analysis.
abstract: Rates of thyroid cancer in women with a history of breast cancer are higher than expected. Similarly, rates of breast cancer in those with a history of thyroid cancer are increased. Explanations for these associations include detection bias, shared hormonal risk factors, treatment effect, and genetic susceptibility. With increasing numbers of breast and thyroid cancer survivors, clinicians should be particularly cognizant of this association. Here, we perform a systematic review and meta-analysis of the literature utilizing PubMed and Scopus search engines to identify all publications studying the incidence of breast cancer as a secondary malignancy following a diagnosis of thyroid cancer or thyroid cancer following a diagnosis of breast cancer. This demonstrated an increased risk of thyroid cancer as a secondary malignancy following breast cancer [OR = 1.55; 95% confidence interval (CI), 1.44-1.67] and an increased risk of breast cancer as a secondary malignancy following thyroid cancer (OR = 1.18; 95% CI, 1.09-1.26). There is a clear increase in the odds of developing either thyroid or breast cancer as a secondary malignancy after diagnosis with the other. Here, we review this association and current hypothesis as to the cause of this correlation.
authors.affiliation: Department of Medicine, Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, Illinois.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Nielsen
authors.affiliation: Endocrine Surgery Research Program, Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois.
authors.forename: Michael G
authors.initials: MG
authors.lastname: White
authors.affiliation: Breast Cancer Survivorship Program, Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois.
authors.forename: Susan
authors.initials: S
authors.lastname: Hong
authors.affiliation: Department of Public Health Sciences, The University of Chicago, Chicago Illinois.
authors.forename: Briseis
authors.initials: B
authors.lastname: Aschebrook-Kilfoy
authors.affiliation: Endocrine Surgery Research Program, Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois.
authors.forename: Edwin L
authors.initials: EL
authors.lastname: Kaplan
authors.affiliation: Endocrine Surgery Research Program, Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois.
authors.forename: Peter
authors.initials: P
authors.lastname: Angelos
authors.affiliation: Department of Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Swati A
authors.initials: SA
authors.lastname: Kulkarni
authors.affiliation: Department of Medicine, Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, Illinois.
authors.forename: Olufunmilayo I
authors.initials: OI
authors.lastname: Olopade
authors.affiliation: Endocrine Surgery Research Program, Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois. rgrogan@surgery.bsd.uchicago.edu.
authors.forename: Raymon H
authors.initials: RH
authors.lastname: Grogan
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology* / Q000401:mortality; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000401:mortality