title: Novel inflammatory markers associated with cognitive performance: Singapore Longitudinal Ageing Studies.
abstract: We identified and validated several novel inflammatory markers of cognitive performance in community-living older persons. An exploratory study (n = 83) correlated 177 inflammatory markers assayed by Luminex with the Mini-Mental State Examination (MMSE) and identified 8 inflammatory markers for enzyme-linked immunosorbent assay (ELISA) and correlations with MMSE, Montreal Cognitive Assessment (MoCA), and cognitive impairment in the validation study (n = 139). The validation study replicated the significant associations of soluble interleukin-2 receptor alpha chain (sIL-2Rα; p = 0.050), soluble tumor necrosis factor receptor 2 (sTNFR2; p = 0.002) and soluble glycoprotein 130 (sgp130; p = 0.026) with MMSE, and sIL-2Rα (p = 0.019) and sgp130 (p < 0.001) with MoCA. Significant trends of associations of tertiles of sgp130, sIL-2Rα, and sTNFR2 were found with cognitive impairment. Highly elevated estimates of association of high versus low tertiles were obtained for sgp130 (odds ratio [OR] = 4.24, 95% confidence interval [CI] 0.96-18.8), sIL-2Rα (OR = 3.94, 95% CI 0.83-18.7), and sTNFR2 (OR = 7.58, 95% CI 1.19-48.1). sgp130, sTNFR2, and sIL-2Rα are promising inflammatory markers of low cognitive performance for further investigation.
authors.affiliation: Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Qi
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), Singapore.
authors.forename: Xavier
authors.initials: X
authors.lastname: Camous
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), Singapore.
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Lu
authors.affiliation: Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: May-Li
authors.initials: ML
authors.lastname: Lim
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), Singapore.
authors.forename: Anis
authors.initials: A
authors.lastname: Larbi
authors.affiliation: Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: pcmngtp@nus.edu.sg.
authors.forename: Tze-Pin
authors.initials: TP
authors.lastname: Ng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000523:psychology*; D015415:Biomarkers / Q000097:blood; D003071:Cognition; D015331:Cohort Studies; D050822:Cytokine Receptor gp130 / Q000097:blood*; D004660:Encephalitis / Q000175:diagnosis* / Q000523:psychology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D057166:High-Throughput Screening Assays; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D047992:TNF Receptor-Associated Factor 2 / Q000097:blood*
chemical_list: D015415:Biomarkers; D053645:Interleukin-2 Receptor alpha Subunit; D047992:TNF Receptor-Associated Factor 2; D050822:Cytokine Receptor gp130
keywords: Aging; Cognition; Inflammation; sIL-2Rα; sTNFR2; sgp130