title: Bordetella pertussis epidemiology and evolution in the light of pertussis resurgence.
abstract: Whooping cough, or pertussis, is resurgent in many countries world-wide. This is linked to switching from the use of whole cell vaccines to acellular vaccines in developed countries. Current evidence suggests that this has resulted in the earlier waning of vaccine-induced immunity, an increase in asymptomatic infection with concomitant increases in transmission and increased selection pressure for Bordetellapertussis variants that are better able to evade vaccine-mediated immunity than older isolates. This review discusses recent findings in B. pertussis epidemiology and evolution in the light of pertussis resurgence, and highlights the important role for genomics-based studies in monitoring B. pertussis adaptation.
authors.affiliation: The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, UK.
authors.forename: Katie L
authors.initials: KL
authors.lastname: Sealey
authors.affiliation: The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Belcher
authors.affiliation: The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, UK. Electronic address: a.preston@bath.ac.uk.
authors.forename: Andrew
authors.initials: A
authors.lastname: Preston
mesh_terms: D000222:Adaptation, Physiological; D001886:Bordetella pertussis / Q000235:genetics* / Q000276:immunology; D006801:Humans; D010567:Pertussis Vaccine / Q000009:adverse effects* / Q000276:immunology; D012641:Selection, Genetic; D014917:Whooping Cough / Q000453:epidemiology*
chemical_list: D010567:Pertussis Vaccine
keywords: Bordetella pertussis; Epidemiology; Evolution; Genomics; Resurgence