title: Highly Stable Nanocontainer of APTES-Anchored Layered Titanate Nanosheet for Reliable Protection/Recovery of Nucleic Acid.
abstract: A universal technology for the encapsulative protection of unstable anionic species by highly stable layered metal oxide has been developed via the surface modification of a metal oxide nanosheet. The surface anchoring of (3-aminopropyl)triethoxysilane (APTES) on exfoliated titanate nanosheet yields a novel cationic metal oxide nanosheet, which can be universally used for the hybridization with various biological and inorganic anions. The encapsulation of deoxyribonucleic acid (DNA) in the cationic APTES-anchored titanate lattice makes possible the reliable long-term protection of DNA against enzymatic, chemical, and UV-vis light corrosions. The encapsulated DNA can be easily released from the titanate lattice via sonication, underscoring the functionality of the cationic APTES-anchored titanate nanosheet as a stable nanocontainer for DNA. The APTES-anchored titanate nanosheet can be also used as an efficient CO2 adsorbent and a versatile host material for various inorganic anions like polyoxometalates, leading to the synthesis of novel intercalative nanohybrids with unexplored properties and useful functionalities.
authors.affiliation: Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
authors.forename: Tae Woo
authors.initials: TW
authors.lastname: Kim
authors.affiliation: Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
authors.forename: In Young
authors.initials: IY
authors.lastname: Kim
authors.affiliation: Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
authors.forename: Dae-Hwan
authors.initials: DH
authors.lastname: Park
authors.affiliation: Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
authors.forename: Jin-Ho
authors.initials: JH
authors.lastname: Choy
authors.affiliation: Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
authors.forename: Seong-Ju
authors.initials: SJ
authors.lastname: Hwang
mesh_terms: D000327:Adsorption; D002245:Carbon Dioxide / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004339:Drug Compounding; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D011437:Propylamines / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013010:Sonication; D014025:Titanium / Q000737:chemistry*; D017973:Tungsten Compounds / Q000737:chemistry; D000099294:Polyoxometalates
chemical_list: D002245:Carbon Dioxide; D004247:DNA; D011437:Propylamines; D012821:Silanes; D014025:Titanium; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates; C009495:titanium dioxide; C477625:amino-propyl-triethoxysilane