title: Interleukin-1β Can Reduce Manifestations of Delayed Effects of Prolonged Exposure to Low-Intensity γ-Radiation.
abstract: We showed that injection of IL-1β (Betaleukin) in a dose of 3 μg/kg 22 h before prolonged (21 h) exposure to low-intensity (10 mGy/min) γ-radiation in a dose of 12.6 Gy reduced the number of double-strand DNA breaks in murine spleen cells to the control level in 4 months after exposure and the number of double-strand DNA breaks induced by additional acute irradiation in a dose of 6 Gy. The results suggest that IL-1β can improve the efficiency of systems reducing the number of double-strand DNA breaks in murine spleen cells at delayed terms after exposure to prolonged low-intensity radiation.
authors.affiliation: Laboratory of Radiation Biophysics, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency, Moscow, Russia. nuv.rad@mail.ru.
authors.forename: N Yu
authors.initials: NY
authors.lastname: Vorobyeva
authors.affiliation: Laboratory of Radiation Biophysics, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency, Moscow, Russia.
authors.forename: A K
authors.initials: AK
authors.lastname: Grekhova
authors.affiliation: Laboratory of Radiation Pharmacology, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency, Moscow, Russia.
authors.forename: K Yu
authors.initials: KY
authors.lastname: Trubitsina
authors.affiliation: Laboratory of Radiation Pharmacology, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Pchelka
authors.affiliation: Laboratory of Radiation Pharmacology, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency, Moscow, Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Rozhdestevenskiy
authors.affiliation: Laboratory of Radiation Pharmacology, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency, Moscow, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Osipov
mesh_terms: D000818:Animals; D004247:DNA / Q000528:radiation effects*; D053903:DNA Breaks, Double-Stranded / Q000187:drug effects* / Q000528:radiation effects*; D004260:DNA Repair / Q000187:drug effects*; D005720:Gamma Rays / Q000009:adverse effects*; D053583:Interleukin-1beta / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology
chemical_list: C587672:IL1B protein, mouse; D053583:Interleukin-1beta; D004247:DNA
keywords: delayed effects of radiation; double-strand DNA breaks; interleukin-1β; low dose rate; γ-radiation