title: Genetic structure and differentiation analysis of a Eurasian Uyghur population by use of 27 continental ancestry-informative SNPs.
abstract: Previously, we developed and validated a multiplex assay of 27 ancestry-informative markers (AIMs) for analyzing African (AFR), European (EUR), and East Asian (EAS) ancestry components. In this study, we typed and collectively analyzed a large Uyghur sample of 979 individuals to estimate the genetic coefficients of the 27 AIMs and investigate differentiation parameters between Uyghur and Han. The Uyghur allele frequencies ranged from 0.243 to 0.952, and heterozygosities ranged from 0.091 to 0.500. Values of F st 3 and I n 3 for EUR, Uyghur, and EAS ranged from 0.028 to 0.550 and 0.0002 to 0.345, respectively. The Uyghur population displays a substantial ancestry contribution of 50.3:49.7 (EUR:EAS) and was efficiently discriminated from Han Chinese with an accuracy of 99.285 %. All populations were clustered into AFR, EUR, EAS, and admixture groups of these three ancestries. Central Asian was obviously stratified from the other admixture populations of South Asians, North Asians, and the Americans. The 27 SNPs yield a circle with an average distance of 0.936 from the center (0, 0) in PCA analysis. Using this set, Chinese Uyghur and Han populations achieved accurate differentiation, and our updated genotype database (by citing 1000 Genomes data) of 43 worldwide populations is a useful resource for forensic applications and disease association studies.
authors.affiliation: Key Laboratory of Forensic Genetics, Ministry of Public Security, Institute of Forensic Science, Beijing, 100038, People's Republic of China. yiliangwei@yahoo.com.|Department of Immunology, Biochemistry and Molecular Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, People's Republic of China. yiliangwei@yahoo.com.|Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, People's Republic of China. yiliangwei@yahoo.com.|Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing, 100038, People's Republic of China. yiliangwei@yahoo.com.
authors.forename: Yi-Liang
authors.initials: YL
authors.lastname: Wei
authors.affiliation: Key Laboratory of Forensic Genetics, Ministry of Public Security, Institute of Forensic Science, Beijing, 100038, People's Republic of China.|Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing, 100038, People's Republic of China.
authors.forename: Qi-Fan
authors.initials: QF
authors.lastname: Sun
authors.affiliation: Department of Nephrology, Tianjin TEDA Hospital, Tianjin, 300457, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: Center Laboratory of Prenatal Diagnosis, Obstetrical, Tsingdao Municipal Hospital, Tsingdao, 266017, Shandong, People's Republic of China.
authors.forename: Jun-Ling
authors.initials: JL
authors.lastname: Yi
authors.affiliation: Key Laboratory of Forensic Genetics, Ministry of Public Security, Institute of Forensic Science, Beijing, 100038, People's Republic of China.|Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing, 100038, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Forensic Genetics, Ministry of Public Security, Institute of Forensic Science, Beijing, 100038, People's Republic of China.|Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing, 100038, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ou
authors.affiliation: Key Laboratory of Forensic Genetics, Ministry of Public Security, Institute of Forensic Science, Beijing, 100038, People's Republic of China.|Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing, 100038, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Forensic Genetics, Ministry of Public Security, Institute of Forensic Science, Beijing, 100038, People's Republic of China.|Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing, 100038, People's Republic of China.|Institution of Forensic Science of Bingtuan Public Security Bureau, Ürümqi, 830000, Xinjiang, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Institution of Forensic Science of Bingtuan Public Security Bureau, Ürümqi, 830000, Xinjiang, People's Republic of China.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Liu
authors.affiliation: Xinjiang Public Security Department, Science and Technology Institute, Ürümqi, 830006, Xinjiang, People's Republic of China.
authors.forename: Jian-Gang
authors.initials: JG
authors.lastname: Chen
authors.affiliation: Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
authors.forename: Bo-Feng
authors.initials: BF
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Forensic Genetics, Ministry of Public Security, Institute of Forensic Science, Beijing, 100038, People's Republic of China.|Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing, 100038, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Ye
authors.affiliation: Key Laboratory of Forensic Genetics, Ministry of Public Security, Institute of Forensic Science, Beijing, 100038, People's Republic of China.|Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing, 100038, People's Republic of China.
authors.forename: Lan
authors.initials: L
authors.lastname: Hu
authors.affiliation: Key Laboratory of Forensic Genetics, Ministry of Public Security, Institute of Forensic Science, Beijing, 100038, People's Republic of China. licaixia@tsinghua.org.cn.|Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing, 100038, People's Republic of China. licaixia@tsinghua.org.cn.
authors.forename: Cai-Xia
authors.initials: CX
authors.lastname: Li
mesh_terms: D002681:China; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis
keywords: Ancestry-informative markers; East Asian; Eurasian; Multiplex assay; SNPs