title: Gallbladder cancer incidence in Gwalior district of India: Five-year trend based on the registry of a regional cancer center.
abstract: BACKGROUND
  We have reported here the 5-year incidence (2004-2008) of gallbladder cancer (GBC) in North Central India along with its descriptive epidemiology. This provides potential clues for better prevention. The present study has also evaluated the association of ABO blood groups with GBC.
  
  
  METHODS
  The study comprised 742 GBC cases referred to the regional cancer hospital, Gwalior, during 2004-2008. The demographic statistics of Gwalior district was considered to calculate the relative risk and incidence rates. ABO blood group distribution amongst 90,000 healthy subjects registered in the local blood bank during 2002-2007 was taken as controls to study the association of blood groups with GBC.
  
  
  RESULTS
  The age-standardized total incidence rate of GBC was calculated to be 7.16/1,00,000. The relative risk of females getting GBC was 2.693 at 95% confidence interval of 2.304-3.151 (P < 0.0001). The females formed 69.5% of total cancer cases, with age-standardized incidence rate of 10/1,00,000. The mean age of male and female GBC cases was found to be 55.4 years (SD = 13, SE = 0.77) and 51.5 years (SD = 12.3, SE = 0.50), respectively. The blood groups A (P = 0.0022) and AB (P < 0.0001) had a positive association with GBC with significant level of differences in comparison to controls.
  
  
  CONCLUSIONS
  Our study provided an estimate of a 5-year incidence of GBC in North Central India for the first time. With regard to the association of risk factors like obesity, age, and urban living with GBC, the findings of the present study are contradictory to the general opinion. Blood groups A and AB were found to be associated with GBC, which would be provisional for further investigations.
authors.forename: M A
authors.initials: MA
authors.lastname: Barbhuiya
authors.forename: T D
authors.initials: TD
authors.lastname: Singh
authors.forename: S S
authors.initials: SS
authors.lastname: Poojary
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: M
authors.initials: M
authors.lastname: Kakkar
authors.forename: B R
authors.initials: BR
authors.lastname: Shrivastav
authors.affiliation: Centre for Genomics, Molecular and Human Genetics, Jiwaji University, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Tiwari
mesh_terms: D000017:ABO Blood-Group System; D005260:Female; D005706:Gallbladder Neoplasms / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000017:ABO Blood-Group System