title: Hypolipidemic Activity of Peony Seed Oil Rich in α-Linolenic, is Mediated Through Inhibition of Lipogenesis and Upregulation of Fatty Acid β-Oxidation.
abstract: Peony seed oil (PSO) is a new resource food rich in α-Linolenic Acid(ALA) (38.66%). The objective of this study was to assess the modulatory effect of PSO on lipid metabolism. Lard oil, safflower oil (SFO), and PSO were fed to wistar rats with 1% cholesterol in the diet for 60 d. Serum and liver lipids showed significant decrease in total cholesterol (TC), triglyceride (TG), and low density lipoprotein-cholesterol (LDL-C) levels in PSO fed rats compared to lard oil and SFO fed rats. ALA, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), contents were significantly increased, whereas linoleic acid (LA), arachidonic acid (AA) levels decreased in serum and liver of PSO fed rats. Feeding PSO increased ALA level and decreased n-6 to n-3 polyunsaturated fatty acid (PUFA) ratio. The hypolipidemic result of PSO indicated that PSO participated in the regulation of plasma lipid concentration and cholesterol metabolism in liver. The decreased expression of sterol regulatory element-binding proteins 1C (SREBP-1c), acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS)-reduced lipid synthesis; Activation of peroxisome proliferator-activator receptor (PPARα) accompanied by increase of uncoupling protein2 (UP2) and acyl-CoA oxidase (AOX) stimulated lipid metabolism and exerted an antiobesity effect via increasing energy expenditure for prevention of obesity.
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan Univ, Lihu Rd. 1800, Wuxi, 214122, PR China.|National Engineering Research Center for Functional Food, Jiangnan Univ, Wuxi, 214122, PR China.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Su
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan Univ, Lihu Rd. 1800, Wuxi, 214122, PR China.|National Engineering Research Center for Functional Food, Jiangnan Univ, Wuxi, 214122, PR China.
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan Univ, Lihu Rd. 1800, Wuxi, 214122, PR China.|National Engineering Research Center for Functional Food, Jiangnan Univ, Wuxi, 214122, PR China.
authors.forename: Chengxiang
authors.initials: C
authors.lastname: Liu
authors.affiliation: Anhui Tongling Ruipu Peony Industry Development Co., Ltd, Anhui, 244000, PR China.
authors.forename: Chuanzhong
authors.initials: C
authors.lastname: Gao
authors.affiliation: Anhui Tongling Ruipu Peony Industry Development Co., Ltd, Anhui, 244000, PR China.
authors.forename: Rongjing
authors.initials: R
authors.lastname: Nie
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan Univ, Lihu Rd. 1800, Wuxi, 214122, PR China.|National Engineering Research Center for Functional Food, Jiangnan Univ, Wuxi, 214122, PR China.
authors.forename: Hongxin
authors.initials: H
authors.lastname: Wang
mesh_terms: D042962:Acyl-CoA Oxidase / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism*; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007473:Ion Channels / Q000378:metabolism; D008055:Lipids / Q000097:blood; D050155:Lipogenesis / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D024101:Mitochondrial Proteins / Q000378:metabolism; D009765:Obesity / Q000378:metabolism* / Q000517:prevention & control; D010084:Oxidation-Reduction; D047493:PPAR alpha / Q000378:metabolism; D029596:Paeonia / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D051780:Sterol Regulatory Element Binding Protein 1 / Q000378:metabolism; D000071246:Uncoupling Protein 2; D015854:Up-Regulation; D017962:alpha-Linolenic Acid / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D005227:Fatty Acids; D000960:Hypolipidemic Agents; D007473:Ion Channels; D008055:Lipids; D024101:Mitochondrial Proteins; D047493:PPAR alpha; D010938:Plant Oils; D051780:Sterol Regulatory Element Binding Protein 1; D000071246:Uncoupling Protein 2; D017962:alpha-Linolenic Acid; D042962:Acyl-CoA Oxidase
keywords: fatty acid synthesis; fatty acid β-oxidation; lipid metabolism; peony seed oil; α-linolenic acid