title: [Analysis of the Effect of Non-phacoemulsification Cataract Operation on Corneal Endothelial Cell Nucleus Division].
abstract: OBJECTIVE
  To investigate the effect of non-phacoemulsification cataract operation in two different patterns of nucleus delivery on the quantity and morphology of corneal endothelial cells and postoperative visual acuity.
  
  
  METHODS
  Forty patients diagnosed with cataract underwent cataract surgery and were assigned into the direct nuclear delivery and semi-nuclear delivery groups. Lens density was measured and divided into the hard and soft lenses according to Emery-little lens nucleus grading system. Non-phacoemulsification cataract operation was performed. At 3 d after surgery, the quantity and morphology of corneal endothelium were counted and observed under corneal endothelial microscope. During 3-month postoperative follow-up, the endothelial cell loss rate, morphological changes and visual acuity were compared among four groups.
  
  
  RESULTS
  Corneal endothelial cell loss rate in the direct delivery of hard nucleus group significantly differed from those in the other three groups before and 3 months after operation (P < 0.01), whereas no statistical significance was found among the direct delivery of soft nucleus, semi-delivery of hard nucleus and semi-delivery soft nucleus groups (all P > 0.05). Preoperative and postoperative 2-d visual acuity did not differ between the semi-delivery of hard nucleus and direct delivery of soft nucleus groups (P = 0.49), significantly differed from those in the semi-delivery of soft nucleus (P = 0.03) and direct delivery of hard nucleus groups (P = 0.14). Visual acuity at postoperative four months did not differ among four groups (P = 0.067).
  
  
  CONCLUSIONS
  During non-phacoemulsification cataract surgery, direct delivery of hard nucleus caused severe injury to corneal endothelium and semi-delivery of soft nucleus yielded mild corneal endothelial injury. Slight corneal endothelial injury exerted no apparent effect upon visual acuity and corneal endothelial morphology at three months after surgery.
authors.forename: Zufeng
authors.initials: Z
authors.lastname: Huang
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Miao
mesh_terms: D002387:Cataract Extraction / Q000009:adverse effects / Q000379:methods*; D048750:Cell Nucleus Division; D055954:Corneal Endothelial Cell Loss / Q000209:etiology* / Q000473:pathology; D004728:Endothelium, Corneal / Q000166:cytology / Q000293:injuries*; D006801:Humans; D007910:Lenses, Intraocular; D018918:Phacoemulsification; D014792:Visual Acuity