title: Severe cryptococcal-associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab.
abstract: Cryptococcosis is a major concern in organ transplant recipients. A decrease in immunosuppressants following the initiation of antifungal therapy is currently recommended, but can occasionally be complicated by the onset of immune reconstitution inflammatory syndrome (IRIS). We report on a case of cryptococcosis in a kidney transplant recipient, compounded by severe neurological IRIS, the outcome of which was unfavorable despite the use of anti-tumor necrosis factor-alpha monoclonal antibodies.
authors.affiliation: Department of Internal Medicine, CHU de Caen, Caen, France.
authors.forename: S
authors.identifier: http://orcid.org/0000-0001-8887-3233
authors.initials: S
authors.lastname: Deshayes
authors.affiliation: Department of Nephrology, CHU de Caen, Caen, France.
authors.forename: N
authors.initials: N
authors.lastname: Bouvier
authors.affiliation: Department of Nephrology, CHU de Caen, Caen, France.
authors.forename: V
authors.initials: V
authors.lastname: Chatelet
authors.affiliation: Department of Nephrology, CHU de Caen, Caen, France.
authors.forename: B
authors.initials: B
authors.lastname: Hurault de Ligny
authors.affiliation: Department of Infectious Diseases, CHU de Caen, Caen, France.
authors.forename: S
authors.initials: S
authors.lastname: Dargère
authors.affiliation: Department of Microbiology, CHU de Caen, Caen, France.
authors.forename: J
authors.initials: J
authors.lastname: Bonhomme
authors.affiliation: Department of Nephrology, CHU de Caen, Caen, France.
authors.forename: C
authors.initials: C
authors.lastname: Béchade
keywords: 
  Cryptococcus neoformans
  ; anti-tumor necrosis factor-alpha monoclonal antibody; cryptococcosis; immune reconstitution inflammatory syndrome; kidney transplantation