title: Headspace screening: A novel approach for fast quality assessment of the essential oil from culinary sage.
abstract: Quality assessment of essential oil (EO) from culinary sage (Salvia officinalis L., Lamiaceae) is limited by the long pharmacopoeial procedure. The aim of this study was to employ headspace (HS) sampling in the quality assessment of sage EO. Different populations (30) of culinary sage were assessed using GC/FID/MS analysis of the hydrodistilled EO (pharmacopoeial method) and HS sampling directly from leaves. Compound profiles from both procedures were evaluated according to ISO 9909 and GDC standards for sage EO quality, revealing compliance for only 10 populations. Factors to convert HS values, for the target ISO and GDC components, into theoretical EO values were calculated. Statistical analysis revealed a significant relationship between HS and EO values for seven target components. Consequently, HS sampling could be used as a complementary extraction technique for rapid screening in quality assessment of sage EOs.
authors.affiliation: Institute of Pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, Macedonia. Electronic address: ivanacvetkovikj@ff.ukim.edu.com.
authors.forename: Ivana
authors.initials: I
authors.lastname: Cvetkovikj
authors.affiliation: Institute of Pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, Macedonia.
authors.forename: Gjoshe
authors.initials: G
authors.lastname: Stefkov
authors.affiliation: Institute of Applied Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, Macedonia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Acevska
authors.affiliation: Institute of Pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, Macedonia.
authors.forename: Marija
authors.initials: M
authors.lastname: Karapandzova
authors.affiliation: Institute of Applied Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, Macedonia.
authors.forename: Aneta
authors.initials: A
authors.lastname: Dimitrovska
authors.affiliation: Institute of Pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, Macedonia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Kulevanova
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009822:Oils, Volatile / Q000032:analysis* / Q000592:standards; D027543:Salvia officinalis / Q000737:chemistry*
chemical_list: D009822:Oils, Volatile
keywords: (HS) GC/FID/MS analysis; 1,8-Cineole (Eucaliptol, PubChem CID=2758); Aroma profiling; Borneol (PubChem CID=10049).; Camphene (PubChem CID=6616); Camphor (PubChem CID=2537); Conversion factors; Essential oil; Quality assessment; Sage; cis-Thujone (PubChem CID=249286); trans-Thujone (Iso-thujone, PubChem CID=91456)