title: Assessment of Serum Concentrations of Ghrelin, Obestatin, Omentin-1, and Apelin in Children with Type 1 Diabetes.
abstract: The increasing knowledge on the functions of gastric peptides and adipokines in the body allows the assumption of their major role linking the process of food intake, nutritional status, and body growth, largely through the regulation of glucose metabolism and insulin resistance. The aim of the study was the assessment of serum levels of selected gastric peptides and adipocytokines in children with type 1 diabetes, with respect to the disease duration. The study involved 80 children aged 4-18 years (M/F -37/43). Children with type 1 diabetes (n = 46) were compared to the control group (n = 34). The study group was divided into 4 subgroups: (I) patients with newly diagnosed type 1 diabetes, after an episode of ketoacidosis (n = 10), (II) patients with type 1 diabetes of duration no longer than 5 years (n = 9), (III) patients with 5 to 10 years of DT1 (n = 20), and (IV) patients with type 1 diabetes of duration longer than 10 years (n = 7). The concentrations of gastric peptide and adipocytokines across all subgroups were lower than in the control group. The differences were statistically significant (p < 0.0001), which may be of importance in the development of the disease complications.
authors.affiliation: Department of Pediatrics, Endocrinology, Diabetology with Subdivision of Cardiology, Medical University of Białystok, Ulica Kilińskiego 1, 15-089 Białystok, Poland; Department of Pediatrics, Endocrinology, Diabetology with Subdivision of Cardiology, Children's University Hospital in Białystok, Ulica Waszyngtona 17, 15-274 Białystok, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Polkowska
authors.affiliation: Department of Pediatrics, Endocrinology, Diabetology with Subdivision of Cardiology, Medical University of Białystok, Ulica Kilińskiego 1, 15-089 Białystok, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Szczepaniak
authors.affiliation: Department of Pediatrics, Endocrinology, Diabetology with Subdivision of Cardiology, Medical University of Białystok, Ulica Kilińskiego 1, 15-089 Białystok, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Bossowski
mesh_terms: D000293:Adolescent; D000073861:Apelin; D001786:Blood Glucose; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000473:pathology; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D007662:Ketosis / Q000097:blood / Q000473:pathology; D037102:Lectins / Q000097:blood*; D008297:Male
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D001786:Blood Glucose; D016207:Cytokines; D058851:GPI-Linked Proteins; D054439:Ghrelin; C432397:ITLN1 protein, human; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D037102:Lectins