title: Effects of Naringenin on Oxidative Stress and Histopathological Changes in the Liver of Lead Acetate Administered Rats.
abstract: Lead has several adverse effects on the body due to one of the environmental pollutants. We aimed to determine the effects of naringenin on the oxidative stress and the hepatic damage against lead acetate treatment in the liver of male rats. Naringenin was administered by orogastric gavage (50 mg/kg) and lead acetate was given as daily 500 parts per million in drinking water for 4 weeks. Lead and antioxidant activities were measured, and histopathological evaluation was performed in the liver. Lead concentrations, malondialdehyde, and antioxidant activity were restored by the naringenin. The grade of necrosis, hydropic degeneration, and hepatic cord disorganization was decreased by the naringenin. However, there were no differences in the degree of sinusoidal congestion, hepatic steatosis, and capsular fibrosis between lead acetate and naringenin + lead acetate groups. We can suggest that naringenin has antioxidant and chelating effects in the liver. Nevertheless, this effect is not enough against the lead acetate induced hepatic injury.
authors.affiliation: Department of Chemistry, Faculty of Science and Art, Adiyaman University, Adiyaman, 02040, Turkey. aozkaya01@gmail.com.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozkaya
authors.affiliation: Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Necmettin Erbakan University, Konya, 42040, Turkey.|Experimental Medicine Research and Application Center (KONÜDAM) of Necmettin Erbakan University, Konya, 42080, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Sahin
authors.affiliation: Department of Chemistry, Faculty of Science and Art, Adiyaman University, Adiyaman, 02040, Turkey.
authors.forename: Uzeyir
authors.initials: U
authors.lastname: Dag
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, 25240, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozkaraca
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D044950:Flavanones / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006651:Histocytochemistry; D007855:Lead Poisoning / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009942:Organometallic Compounds / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D044950:Flavanones; D009942:Organometallic Compounds; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D005978:Glutathione; C005273:naringenin; C008261:lead acetate
keywords: Antioxidant; Lead Acetate; Liver Injury; Naringenin