title: Exceptional Response to Systemic Therapy in Advanced Metastatic Gastric Cancer: A Case Report.
abstract: Gastroesophageal adenocarcinomas represent one of the top five most common types of cancer worldwide. Despite significant advancement, it is still not known which first-line chemotherapy option is best matched to an individual patient. The vast advances in molecular biology have led to the discovery of many potential predictive biomarkers, such as HER-2 neu, thymidylate synthase (TS), excision repair cross-complementation group 1 (ERCC1), and topoisomerase-1 (TOPO1). These markers could allow us to select treatment based on an individual's tumor profile, resulting in an improvement of outcome. Our report highlights two patients with metastatic gastric cancer that achieved an exceptional response with traditional therapy and provides insights into the future perspectives of molecular profile-directed chemotherapy.
authors.affiliation: Oncology, Medstar Georgetown University Hospital.
authors.forename: Bradley
authors.initials: B
authors.lastname: Colton
authors.affiliation: Oncology, Medstar Georgetown University Hospital.
authors.forename: Marion
authors.initials: M
authors.lastname: Hartley
authors.affiliation: Radiology, Medstar Georgetown University Hospital.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Manning
authors.affiliation: Gastroenterology, Medstar Georgetown University Hospital.
authors.forename: John E
authors.initials: JE
authors.lastname: Carroll
authors.affiliation: Oncology, Caris Life Sciences.
authors.forename: Joanne
authors.initials: J
authors.lastname: Xiu
authors.affiliation: Oncology, Medstar Georgetown University Hospital.
authors.forename: Brandon G
authors.initials: BG
authors.lastname: Smaglo
authors.affiliation: Oncology, The Ohio State University-James Cancer Hospital and Richard Solove Research Institute.
authors.forename: Sameh
authors.initials: S
authors.lastname: Mikhail
authors.affiliation: Oncology, Medstar Georgetown University Hospital.
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Salem
keywords: cancer biomarkers; cancer treatment; ercc1; esophagogastric adenocarcinoma; gastric cancer; her2; molecular profiling; thymidylate synthase; topoisomerase 1