title: Protein-lipid interactions critical to replication of the influenza A virus.
abstract: Influenza A virus (IAV) assembles on the plasma membrane where viral proteins localize to form a bud encompassing the viral genome, which ultimately pinches off to give rise to newly formed infectious virions. Upon entry, the virus faces the opposite task-fusion with the endosomal membrane and disassembly to deliver the viral genome to the cytoplasm. There are at least four influenza proteins-hemagglutinin (HA), neuraminidase (NA), matrix 1 protein (M1), and the M2 ion channel-that are known to directly interact with the cellular membrane and modify membrane curvature in order to both assemble and disassemble membrane-enveloped virions. Here, we summarize and discuss current knowledge of the interactions of lipids and membrane proteins involved in the IAV replication cycle.
authors.affiliation: Section on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Petr
authors.initials: P
authors.lastname: Chlanda
authors.affiliation: Section on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: Zimmerberg
mesh_terms: D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D009980:Influenza A virus / Q000502:physiology* / Q000648:ultrastructure; D050356:Lipid Metabolism; D014764:Viral Proteins / Q000378:metabolism*; D053586:Virus Internalization; D014779:Virus Replication / Q000502:physiology*
chemical_list: D014764:Viral Proteins
keywords: influenza virus; lipid microdomains; membrane fission; membrane fusion; virus budding; virus entry