title: Risk Factors for Hypertension After Living Donor Kidney Transplantation in Korea: A Multivariate Analysis.
abstract: BACKGROUND
  Post-transplantation hypertension is very common and is associated with cardiovascular complications and poor graft survival in kidney transplant recipients. This study aimed to identify risk factors for hypertension after living donor kidney transplantation.
  
  
  METHODS
  We retrospectively analyzed patients who underwent renal transplantation between January 2009 and April 2012. Hypertension was defined as the use of antihypertensive medications at 12 months post-transplantation. Student t test and chi-squared test were performed for univariate analysis. Logistic regression analysis was performed for multivariate analysis.
  
  
  RESULTS
  Five-hundred thirty-nine patients were enrolled in the analyses. The rate of antihypertensive medication use was 67% at 12 months. In multivariate analysis, male gender (odds ratio [OR], 2.68; 95% confidence interval [CI], 1.55-4.61), pretransplantation hypertension (OR, 4.65; 95% CI, 2.14-10.11), donor hypertension (OR, 3.23; 95% CI, 1.05-9.96), high body mass index (BMI; OR, 1.21; 95% CI, 1.12-1.29), and use of cyclosporine (OR, 2.05; 95% CI, 1.28-3.27) were associated with post-transplantation hypertension.
  
  
  CONCLUSIONS
  These data show that male recipient, hypertension before transplantation, donor hypertension, high BMI, and cyclosporine use were independent factors associated with hypertension. It would be useful to predict and prevention the hypertension after kidney transplantation.
authors.affiliation: Division of Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: H
authors.initials: H
authors.lastname: Yu
authors.affiliation: Division of Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Division of Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: C H
authors.initials: CH
authors.lastname: Baek
authors.affiliation: Division of Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: E H
authors.initials: EH
authors.lastname: Shin
authors.affiliation: Division of Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: H J
authors.initials: HJ
authors.lastname: Cho
authors.affiliation: Division of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: D J
authors.initials: DJ
authors.lastname: Han
authors.affiliation: Division of Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address: skpark@amc.seoul.kr.
authors.forename: S K
authors.initials: SK
authors.lastname: Park
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D015992:Body Mass Index; D016572:Cyclosporine / Q000009:adverse effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology*; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011183:Postoperative Complications; D011184:Postoperative Period; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D000959:Antihypertensive Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine