title: Dietary restriction with and without caloric restriction for healthy aging.
abstract: Caloric restriction is the most effective and reproducible dietary intervention known to regulate aging and increase the healthy lifespan in various model organisms, ranging from the unicellular yeast to worms, flies, rodents, and primates. However, caloric restriction, which in most cases entails a 20-40% reduction of food consumption relative to normal intake, is a severe intervention that results in both beneficial and detrimental effects. Specific types of chronic, intermittent, or periodic dietary restrictions without chronic caloric restriction have instead the potential to provide a significant healthspan increase while minimizing adverse effects. Improved periodic or targeted dietary restriction regimens that uncouple the challenge of food deprivation from the beneficial effects will allow a safe intervention feasible for a major portion of the population. Here we focus on healthspan interventions that are not chronic or do not require calorie restriction.
authors.affiliation: Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
authors.forename: Changhan
authors.initials: C
authors.lastname: Lee
authors.affiliation: Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA; IFOM - FIRC Institute of Molecular Oncology Foundation, Milan, Italy.
authors.forename: Valter
authors.initials: V
authors.lastname: Longo
keywords: Caloric restriction; Dietary restriction; aging; healthspan; mechanisms of aging