title: Essential Oil Composition of Phagnalon sordidum (L.) from Corsica, Chemical Variability and Antimicrobial Activity.
abstract: The chemical composition of Phagnalon sordidum (L.) essential oil was investigated for the first time using gas chromatography and chromatography/mass spectrometry. Seventy-six compounds, which accounted for 87.9% of the total amount, were identified in a collective essential oil of P. sordidum from Corsica. The main essential oil components were (E)-β-caryophyllene (14.4%), β-pinene (11.0%), thymol (9.0%), and hexadecanoic acid (5.3%). The chemical compositions of essential oils from 19 Corsican locations were investigated. The study of the chemical variability using statistical analysis allowed identifying direct correlation between the three populations of P. sordidum widespread in Corsica and the essential oil compositions they produce. The in vitro antimicrobial activity of P. sordidum essential oil was evaluated and it exhibited a notable activity on a large panel of clinically significant microorganisms.
authors.affiliation: Laboratoire Chimie des Produits Naturels, UMR-CNRS 6134 SPE, Université de Corse, Campus Grimaldi, BP 52, 20250, Corte, France.|Laboratoire PHENOBIO SAS, Centre Montesquieu, 1 Allée Jean Rostand, 33650, Martillac, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Brunel
authors.affiliation: Laboratoire PHENOBIO SAS, Centre Montesquieu, 1 Allée Jean Rostand, 33650, Martillac, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Vitrac
authors.affiliation: Laboratoire Chimie des Produits Naturels, UMR-CNRS 6134 SPE, Université de Corse, Campus Grimaldi, BP 52, 20250, Corte, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Costa
authors.affiliation: Aquitaine Microbiologie, Université de Bordeaux, 146 rue Léo Saignat, 33076, Bordeaux, France.
authors.forename: Fatima
authors.initials: F
authors.lastname: Mzali
authors.affiliation: Laboratoire PHENOBIO SAS, Centre Montesquieu, 1 Allée Jean Rostand, 33650, Martillac, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Vitrac
authors.affiliation: Laboratoire Chimie des Produits Naturels, UMR-CNRS 6134 SPE, Université de Corse, Campus Grimaldi, BP 52, 20250, Corte, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Muselli
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005602:France; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D009822:Oils, Volatile
keywords: Anti-microorganism screening; Chemical variability; Essential oils; Gas chromatography; Gas chromatography/Mass spectrometry; Phagnalon sordidum