title: Pulse Radiolysis Using Very-high-energy Ions for Optimizing Cancer Therapy.
abstract: Cancer therapy by means of high-energy ions is very efficient. As a consequence of the linear-energy-transfer effect only a negligible part of the produced free radicals can escape combination processes to form molecular products and to cause undesired side processes. Positrons (e⁺) and γ-rays, generated by the nuclear interaction of high-energy ions in the medium, serve in monitoring the radiation dose absorbed by the tumor. However, due to the dipole nature of water molecules a small proportion of thermalized positrons (e⁺th) can become solvated (e⁺aq). Hence, they are stabilized, live longer and can initiate side reactions. In addition, positronium (Ps), besides solvated electrons (e⁺aq), can be generated and involved in the reaction mechanisms. For a better understanding of the reaction mechanisms involved and to improve cancer therapy, a time-resolved pulse radiolysis instrument using high-energy particles is discussed here. The proposed method is examined and recommended by CERN experts. It is planned to be realized at the MedAustron Radiation Therapy and Research Centre in Wiener Neustadt, Austria.
authors.affiliation: Section of Radiation Biology, Department for Nutritional Sciences, Faculty of Life Science, The University of Vienna, Vienna, Austria nikola.getoff@univie.ac.at.
authors.forename: Nikola
authors.initials: N
authors.lastname: Getoff
mesh_terms: D004583:Electrons; D005720:Gamma Rays; D006801:Humans; D007477:Ions / Q000627:therapeutic use*; D009369:Neoplasms / Q000532:radiotherapy*; D011675:Pulse Radiolysis / Q000295:instrumentation / Q000379:methods*
chemical_list: D007477:Ions
keywords: Pulse radiolysis; cancer therapy; high-energy particles; positronium; solvated positrons”; “solvated electrons