title: Prostate cancer risk among French farmers in the AGRICAN cohort.
abstract: OBJECTIVE
  Prostate cancer is one of the most frequent cancers among men worldwide. Its etiology is largely unknown, but an increased risk has been repeatedly observed among farmers. Our aim was to identify occupational risk factors for prostate cancer among farmers in the prospective cohort study AGRICAN.
  
  
  METHODS
  Data on lifetime agricultural exposures (type of crops, livestock and tasks including pesticide use, re-entry and harvesting) were collected from the enrolment questionnaire. During the period from enrolment (2005-2007) to 31 December 2009, 1672 incident prostate cancers were identified. Hazard ratios (HR) were estimated using Cox regression analysis.
  
  
  RESULTS
  We found an increased risk for cattle breeders using insecticides [HR 1.20, 95% confidence interval (95% CI) 1.01-1.42] with a significant dose-response relationship with number of cattle treated (P for trend 0.01). A dose-response relationship was also observed with the number of hogs (P for trend 0.06). We found an excess of prostate cancer risk among people involved in grassland activities, mainly in haymaking (HR 1.18, 95% CI 1.02-1.36). Pesticide use and harvesting among fruit growers were associated with an elevated prostate cancer risk, with a two-fold increased risk for the largest area. For potato and tobacco producers, an elevated prostate cancer risk was observed for almost all tasks, suggesting a link with pesticide exposure since all of them potentially involved pesticide exposure.
  
  
  CONCLUSIONS
  Our analysis suggests that the risk of prostate cancer is increased in several farming activities (cattle and hog breeding, grassland and fruit-growing) and for some tasks including pesticide use.
authors.affiliation: Université de Caen, Normandie, UMR 1086 Cancers et Préventions, Caen, France. c.lemarchand@mail.baclesse.fr.
authors.forename: Clémentine
authors.initials: C
authors.lastname: Lemarchand
authors.forename: Séverine
authors.initials: S
authors.lastname: Tual
authors.forename: Mathilde
authors.initials: M
authors.lastname: Boulanger
authors.forename: Noémie
authors.initials: N
authors.lastname: Levêque-Morlais
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Perrier
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Clin
authors.forename: Anne-Valérie
authors.initials: AV
authors.lastname: Guizard
authors.forename: Michel
authors.initials: M
authors.lastname: Velten
authors.forename: Emma
authors.initials: E
authors.lastname: Rigaud
authors.forename: Isabelle
authors.initials: I
authors.lastname: Baldi
authors.forename: Pierre
authors.initials: P
authors.lastname: Lebailly
mesh_terms: D000368:Aged; D000382:Agricultural Workers' Diseases / Q000139:chemically induced*; D016573:Agrochemicals / Q000009:adverse effects*; D000818:Animals; D015331:Cohort Studies; D000067565:Farmers; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D010575:Pesticides / Q000009:adverse effects*; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000139:chemically induced*; D012307:Risk Factors
chemical_list: D016573:Agrochemicals; D010575:Pesticides