title: Retinal vein occlusion and the risk of acute myocardial infarction development: a 12-year nationwide cohort study.
abstract: The goal of this study was to evaluate the risk of developing acute myocardial infarction (AMI) following retinal vein occlusion (RVO). A retrospective cohort study was performed from the National Health Insurance Service and comprised 1,025,340 random subjects who were followed from 2002 to 2013. Patients with RVO in 2002 were excluded. The RVO group was composed of patients who received an initial RVO diagnosis between January 2003 and December 2007 (n = 1677). The comparison group was selected (five patients per RVO patient; n = 8367) using propensity score matching according to sociodemographic factors and the year of enrolment. Each patient was tracked until 2013. The Cox proportional hazard regression model was used. AMI developed in 7.6% of the RVO group and 5.3% of the comparison group (p < 0.001) for 7.7 median follow-up periods. RVO increased the risk of AMI development [hazard ratio (HR) = 1.25; 95% Confidence Interval (CI) 1.02 to 1.52]. In the subgroup analysis, RVO patients aged <65 years and the males within this age group had an adjusted HR of 1.47 (95% CI 1.10 to 1.98) and an adjusted HR of 2.00 (95% CI 1.38 to 2.91) for AMI development, respectively. RVO was significantly associated with AMI development.
authors.affiliation: Department of Ophthalmology, National Health Insurance Service Ilsan Hospital, Goyang, Gyeonggi, Korea.
authors.forename: Tyler Hyungtaek
authors.initials: TH
authors.lastname: Rim
authors.affiliation: Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: John Seungsoo
authors.initials: JS
authors.lastname: Han
authors.affiliation: Division of Cardiology, Severance Cardiovascular Hospital, Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jaewon
authors.initials: J
authors.lastname: Oh
authors.affiliation: Department of Policy Research Affairs, National Health Insurance Service Ilsan Hospital, Goyang, Gyeonggi, Korea.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Severance Cardiovascular Hospital, Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Seok-Min
authors.initials: SM
authors.lastname: Kang
authors.affiliation: Department of Ophthalmology, National Health Insurance Service Ilsan Hospital, Goyang, Gyeonggi, Korea.
authors.forename: Eun Jee
authors.initials: EJ
authors.lastname: Chung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000209:etiology*; D011159:Population Surveillance; D016016:Proportional Hazards Models; D056910:Republic of Korea / Q000453:epidemiology; D012170:Retinal Vein Occlusion / Q000453:epidemiology*; D012189:Retrospective Studies; D012306:Risk; D012959:Socioeconomic Factors