title: Skin Antiageing and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant-Derived Antioxidants: A Single-Blind Case-Control Clinical Study.
abstract: Recently, development and research of nutraceuticals based on marine collagen peptides (MCPs) have been growing due to their high homology with human collagens, safety, bioavailability through gut, and numerous bioactivities. The major concern regarding safety of MCPs intake relates to increased risk of oxidative stress connected with collagen synthesis (likewise in fibrosis) and to ROS production by MCPs-stimulated phagocytes. In this clinical-laboratory study, fish skin MCPs combined with plant-derived skin-targeting antioxidants (AO) (coenzyme Q10 + grape-skin extract + luteolin + selenium) were administered to volunteers (n = 41). Skin properties (moisture, elasticity, sebum production, and biological age) and ultrasonic markers (epidermal/dermal thickness and acoustic density) were measured thrice (2 months before treatment and before and after cessation of 2-month oral intake). The supplementation remarkably improved skin elasticity, sebum production, and dermal ultrasonic markers. Metabolic data showed significant increase of plasma hydroxyproline and ATP storage in erythrocytes. Redox parameters, GSH/coenzyme Q10 content, and GPx/GST activities were unchanged, while NO and MDA were moderately increased within, however, normal range of values. Conclusions. A combination of MCPs with skin-targeting AOs could be effective and safe supplement to improve skin properties without risk of oxidative damage.
authors.affiliation: Evidence-Based Well-Being Ltd., 31 Alt-Stralau, 10245 Berlin, Germany.
authors.forename: Chiara
authors.initials: C
authors.lastname: De Luca
authors.affiliation: Russian Institute of Physical Chemical Medicine, 1A Malaya Pirogovskaya Street, Moscow 117513, Russia.
authors.forename: Elena V
authors.initials: EV
authors.lastname: Mikhal'chik
authors.affiliation: Russian Institute of Physical Chemical Medicine, 1A Malaya Pirogovskaya Street, Moscow 117513, Russia.
authors.forename: Maxim V
authors.initials: MV
authors.lastname: Suprun
authors.affiliation: Dermatology Clinic "Orthobiotiki Clinical", 3-5 Sorou Street, 15125 Athens, Greece.
authors.forename: Michael
authors.initials: M
authors.lastname: Papacharalambous
authors.affiliation: Active Longevity Clinic, Beauty Institute on Arbat, 8 Maliy Nikolopeskovskiy Lane, Moscow 119002, Russia.
authors.forename: Arseniy I
authors.initials: AI
authors.lastname: Truhanov
authors.affiliation: Active Longevity Clinic, Beauty Institute on Arbat, 8 Maliy Nikolopeskovskiy Lane, Moscow 119002, Russia; Centre of Innovative Biotechnological Investigations (CIBI-Nanolab), 197 Vernadskogo Prospekt, Moscow 119571, Russia.
authors.forename: Liudmila G
authors.initials: LG
authors.lastname: Korkina
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000737:chemistry*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003094:Collagen / Q000494:pharmacology*; D019587:Dietary Supplements; D005145:Face; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010084:Oxidation-Reduction / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry*; D016037:Single-Blind Method; D012867:Skin / Q000000981:diagnostic imaging; D015595:Skin Aging / Q000187:drug effects*; D014465:Ultrasonics
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D010455:Peptides; D000255:Adenosine Triphosphate; D003094:Collagen; D005978:Glutathione