title: History of uterine leiomyoma and risk of endometrial cancer in black women.
abstract: BACKGROUND
  Previous studies have found an association between uterine leiomyomata (UL) and uterine malignancies. This relation has not been studied in black women, who are disproportionately affected by UL.
  
  
  METHODS
  We investigated prospectively the association between self-reported physician-diagnosed UL and endometrial cancer in the Black Women's Health Study. During 1995-2013, 47,267 participants with intact uteri completed biennial health questionnaires. Reports of endometrial cancer were confirmed by pathology data from medical records and cancer registries. Cox regression was used to derive incidence rate ratios (IRR) and 95% confidence intervals (CI).
  
  
  RESULTS
  There were 300 incident endometrial cancer cases during 689,546 person-years of follow-up. In multivariable models, UL history was associated with a 42% greater incidence of endometrial cancer compared with no such history (95% CI 1.12-1.80). IRRs for cancer diagnosed 0-2, 3-9, and ≥10 years after UL diagnosis were 3.20 (95% CI 2.06-4.98), 0.95 (95% CI 0.60-1.52), and 1.35 (95% CI 1.03-1.77), respectively. Stronger overall associations between UL history and endometrial cancer were observed for later stages at cancer diagnosis (IRR = 2.25, 95% CI 1.09-4.63) and type II/III cancers (IRR = 3.13, 95% CI 1.64-5.99).
  
  
  CONCLUSIONS
  In this large cohort of black women, a history of UL was positively associated with endometrial cancer, particularly type II/III tumors. The strongest association was observed for cancer diagnosed within 2 years of UL diagnosis, a finding that might be explained by greater surveillance of women with UL or misdiagnosis of cancer as UL. However, an association was also observed for cancer reported ≥10 years after UL diagnosis.
authors.affiliation: Slone Epidemiology Center at Boston University, Boston, MA, USA. lwise@bu.edu.|Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. lwise@bu.edu.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Wise
authors.affiliation: Slone Epidemiology Center at Boston University, Boston, MA, USA.|Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
authors.forename: Todd R
authors.initials: TR
authors.lastname: Sponholtz
authors.affiliation: Slone Epidemiology Center at Boston University, Boston, MA, USA.
authors.forename: Lynn
authors.initials: L
authors.lastname: Rosenberg
authors.affiliation: Lombardi Cancer Center, Georgetown University, Washington, DC, USA.
authors.forename: Lucile L
authors.initials: LL
authors.lastname: Adams-Campbell
authors.affiliation: Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA, USA.
authors.forename: Wendy
authors.initials: W
authors.lastname: Kuohung
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: LaValley
authors.affiliation: Slone Epidemiology Center at Boston University, Boston, MA, USA.
authors.forename: Julie R
authors.initials: JR
authors.lastname: Palmer
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007889:Leiomyoma / Q000453:epidemiology*; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014594:Uterine Neoplasms / Q000453:epidemiology*
keywords: African-Americans; Endometrial cancer; Prospective studies; Uterine leiomyoma