title: Disrupted Resting-State Functional Connectivity in Nonmedicated Bipolar Disorder.
abstract: Purpose To investigate the whole-brain intrinsic functional connectivity patterns of patients with bipolar disorder (BD). Materials and Methods This prospective study was approved by the research ethics committee, and all participants provided informed consent. Thirty-seven patients with nonmedicated BD II depression and 37 healthy control participants underwent resting-state functional magnetic resonance (MR) imaging. Whole-brain connectivity was analyzed by using a graph theory approach: functional connectivity strength (FCS). Clinical state was assessed by using the 24-item Hamilton Depression Rating Scale and the Young Mania Rating Scale. Two-sample t test and nonparametric correlation analysis were used. Results Compared with healthy control participants, patients with BD II showed decreased FCS in the default mode network (ie, the bilateral medial prefrontal cortex, bilateral middle temporal gyrus, left precuneus, and right posterior cingulate cortex), right supramarginal gyrus and angular gyrus, right superior frontal gyrus, and right superior parietal gyrus and increased FCS in the bilateral temporal pole (including the parahippocampal gyrus and amygdale), left anterior cingulate cortex, left superior temporal gyrus, right lingual gyrus, and left anterior lobe of the cerebellum (P < .05; AlphaSim corrected). Conclusion These results suggest that patients with BD have disrupted intrinsic functional connectivity mainly in the default mode network and limbic system, which might be associated with the pathophysiologic structure of BD. (©) RSNA, 2016.
authors.affiliation: From the Clinical Experimental Center (Y.W.), Medical Imaging Center (Y.W., Y.S., L.H.), and Department of Psychiatry (S.Z., Y.J., B.W., T.L.), First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: From the Clinical Experimental Center (Y.W.), Medical Imaging Center (Y.W., Y.S., L.H.), and Department of Psychiatry (S.Z., Y.J., B.W., T.L.), First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Shuming
authors.initials: S
authors.lastname: Zhong
authors.affiliation: From the Clinical Experimental Center (Y.W.), Medical Imaging Center (Y.W., Y.S., L.H.), and Department of Psychiatry (S.Z., Y.J., B.W., T.L.), First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Jia
authors.affiliation: From the Clinical Experimental Center (Y.W.), Medical Imaging Center (Y.W., Y.S., L.H.), and Department of Psychiatry (S.Z., Y.J., B.W., T.L.), First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Sun
authors.affiliation: From the Clinical Experimental Center (Y.W.), Medical Imaging Center (Y.W., Y.S., L.H.), and Department of Psychiatry (S.Z., Y.J., B.W., T.L.), First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.affiliation: From the Clinical Experimental Center (Y.W.), Medical Imaging Center (Y.W., Y.S., L.H.), and Department of Psychiatry (S.Z., Y.J., B.W., T.L.), First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: From the Clinical Experimental Center (Y.W.), Medical Imaging Center (Y.W., Y.S., L.H.), and Department of Psychiatry (S.Z., Y.J., B.W., T.L.), First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Jiyang
authors.initials: J
authors.lastname: Pan
authors.affiliation: From the Clinical Experimental Center (Y.W.), Medical Imaging Center (Y.W., Y.S., L.H.), and Department of Psychiatry (S.Z., Y.J., B.W., T.L.), First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Li
authors.initials: L
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012146:Rest; D055815:Young Adult