title: Chemokines and Chemokine Receptors in Lymphoid Tissue Dynamics.
abstract: The continuous migration of immune cells between lymphoid and nonlymphoid organs is a key feature of the immune system, facilitating the distribution of effector cells within nearly all compartments of the body. Furthermore, reaching their correct position within primary, secondary, or tertiary lymphoid organs is a prerequisite to ensure immune cells' unimpaired differentiation, maturation, and selection, as well as their activation or functional silencing. The superfamilies of chemokines and chemokine receptors are of major importance in guiding immune cells to and within lymphoid and nonlymphoid tissues. In this review we focus on the role of the chemokine system in the migration dynamics of immune cells within lymphoid organs at the steady state and on how these dynamics are affected by infectious and inflammatory processes.
authors.affiliation: Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany; email: foerster.reinhold@mh-hannover.de.
authors.forename: Olga
authors.initials: O
authors.lastname: Schulz
authors.affiliation: Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany; email: foerster.reinhold@mh-hannover.de.
authors.forename: Swantje I
authors.initials: SI
authors.lastname: Hammerschmidt
authors.affiliation: Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany; email: foerster.reinhold@mh-hannover.de.
authors.forename: G Leandros
authors.initials: GL
authors.lastname: Moschovakis
authors.affiliation: Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany; email: foerster.reinhold@mh-hannover.de.
authors.forename: Reinhold
authors.initials: R
authors.lastname: Förster
mesh_terms: D000818:Animals; D002450:Cell Communication; D002465:Cell Movement; D018925:Chemokines / Q000276:immunology*; D006801:Humans; D007107:Immune System; D007239:Infections / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology*; D019707:Receptors, Chemokine / Q000276:immunology*
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine
keywords: cell migration; lymph node; lymphoid organ development; lymphoid organ function; spleen; thymus