title: Circulating Endothelial Cells and Endothelial Progenitor Cells in Pediatric Sepsis.
abstract: OBJECTIVE
  The aim of the study was to measure the number of circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPs) in pediatric patients with sepsis and correlating it with the severity of the disease and its outcome.
  
  
  METHODS
  The study included 19 children with sepsis, 26 with complicated sepsis, and 30 healthy controls. The patients were investigated within 48 hours of pediatric intensive care unit admission together with flow cytometric detection of CECs and CEPs.
  
  
  RESULTS
  The levels of both CECs and CEPs were significantly higher in patient with sepsis and complicated sepsis than the controls. The levels of CECs were higher in patients with complicated sepsis, whereas the levels of CEPs were lower in patients with complicated sepsis. Comparing the survival and nonsurvival septic patients, the levels of CEPs were significantly higher in the survival than in nonsurvival patients, whereas the levels of CECs were significantly lower in the survival than in nonsurvival patients. Serum albumin was higher in survival than in nonsurvival patients.
  
  
  CONCLUSIONS
  Estimation of CECs and CEPs and their correlation with other parameters such as serum albumen could add important information regarding prognosis in septic pediatric patients.
authors.affiliation: From the *Oncological Clinical Pathology Department, South Egypt Cancer Institute, Assiut University; †Pediatric Department, Assiut University Children Hospital, Assiut, Egypt; ‡King Saud University, Riyadh, Saudi Arabia; and §Clinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
authors.forename: Asmaa Mohamad
authors.initials: AM
authors.lastname: Zahran
authors.forename: Khalid Ibrahim
authors.initials: KI
authors.lastname: Elsayh
authors.forename: Ismail Lotfy
authors.initials: IL
authors.lastname: Mohamad
authors.forename: Gamal Mohamad
authors.initials: GM
authors.lastname: Hassan
authors.forename: Madleen Adel A
authors.initials: MA
authors.lastname: Abdou
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D042783:Endothelial Cells / Q000473:pathology*; D066026:Endothelial Progenitor Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D008297:Male; D011379:Prognosis; D018805:Sepsis / Q000097:blood* / Q000473:pathology*; D012709:Serum Albumin / Q000378:metabolism; D016019:Survival Analysis
chemical_list: D012709:Serum Albumin