title: (99m)Tc-aprotinin - optimisation and validation of radiolabelling kits for routine preparation for diagnostic imaging of amyloidosis.
abstract: Technetium-99m aprotinin was prepared from an optimised radiolabelling kit formulation containing aprotinin, alkaline buffer and stannous chloride (reducing agent) and radiolabelled using (99m) Tc-pertechnetate. The labelling was achieved within 25 min, with radiochemical purities of >98%.
authors.affiliation: Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Rigshospitalet, Denmark.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Denholt
authors.affiliation: Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Rigshospitalet, Denmark.
authors.forename: Nic
authors.identifier: http://orcid.org/0000-0002-7669-2344
authors.initials: N
authors.lastname: Gillings
mesh_terms: D000686:Amyloidosis / Q000000981:diagnostic imaging*; D007611:Aprotinin / Q000737:chemistry*; D003952:Diagnostic Imaging; D007553:Isotope Labeling / Q000379:methods*; D011854:Radiochemistry; D013667:Technetium / Q000737:chemistry*
chemical_list: D013667:Technetium; D007611:Aprotinin
keywords: 99mTc-aprotinin; Aprotinin; HPLC; Technetium-99m; Validation; amyloidosis