title: Clinical evaluation of ultra-high-field MRI for three-dimensional visualisation of tumour size in uveal melanoma patients, with direct relevance to treatment planning.
abstract: OBJECTIVE
  To assess the tumour dimensions in uveal melanoma patients using 7-T ocular MRI and compare these values with conventional ultrasound imaging to provide improved information for treatment options.
  
  
  METHODS
  Ten uveal melanoma patients were examined on a 7-T MRI system using a custom-built eye coil and dedicated 3D scan sequences to minimise eye-motion-induced image artefacts. The maximum tumour prominence was estimated from the three-dimensional images and compared with the standard clinical evaluation from 2D ultrasound images.
  
  
  RESULTS
  The MRI protocols resulted in high-resolution motion-free images of the eye in which the tumour and surrounding tissues could clearly be discriminated. For eight of the ten patients the MR images showed a slightly different value of tumour prominence (average 1.0 mm difference) compared to the ultrasound measurements, which can be attributed to the oblique cuts through the tumour made by the ultrasound. For two of these patients the more accurate results from the MR images changed the treatment plan, with the smaller tumour dimensions making them eligible for eye-preserving therapy.
  
  
  CONCLUSIONS
  High-field ocular MRI can yield a more accurate measurement of the tumour dimensions than conventional ultrasound, which can result in significant changes in the prescribed treatment.
authors.affiliation: Department of Radiology, C.J. Gorter Center for High-field MRI, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. j.w.m.beenakker@lumc.nl.|Department of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. j.w.m.beenakker@lumc.nl.
authors.forename: Jan-Willem M
authors.initials: JW
authors.lastname: Beenakker
authors.affiliation: Department of Radiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
authors.forename: Teresa A
authors.initials: TA
authors.lastname: Ferreira
authors.affiliation: Department of Radiology, C.J. Gorter Center for High-field MRI, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
authors.forename: Karina P
authors.initials: KP
authors.lastname: Soemarwoto
authors.affiliation: Department of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
authors.forename: Stijn W
authors.initials: SW
authors.lastname: Genders
authors.affiliation: Department of Radiology, C.J. Gorter Center for High-field MRI, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
authors.forename: Wouter M
authors.initials: WM
authors.lastname: Teeuwisse
authors.affiliation: Department of Radiology, C.J. Gorter Center for High-field MRI, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Webb
authors.affiliation: Department of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
authors.forename: Gregorius P M
authors.initials: GP
authors.lastname: Luyten
mesh_terms: D016477:Artifacts; D001918:Brachytherapy; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy; D009885:Ophthalmology / Q000379:methods; D011880:Radiotherapy Planning, Computer-Assisted; D014463:Ultrasonography; D014604:Uveal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy; D000098943:Uveal Melanoma
keywords: Eye; Magnetic resonance imaging (MRI); Ophthalmology; Ultrasound; Uveal melanoma