title: Mitochondria and senescence: new actors for an old play.
abstract: Mitochondrial dysfunction has been linked to both cellular senescence and ageing. Despite the relationship, it is still unclear whether mitochondria have a causal role in senescence. In this issue of The EMBO Journal, Correia-Melo et al (2016) combine targeted depletion of mitochondria with impairment of their biogenesis to demonstrate that decreased numbers of mitochondria impair the senescence response. Their results suggest that targeting mitochondria could reduce the detrimental effects of senescence during ageing.
authors.affiliation: Cell Proliferation Group, MRC Clinical Sciences Centre Imperial College London, London, UK.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Herranz
authors.affiliation: Cell Proliferation Group, MRC Clinical Sciences Centre Imperial College London, London, UK.
authors.forename: Jesús
authors.initials: J
authors.lastname: Gil
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000502:physiology*