title: [Meta-analysis of The olfaction effectiveness of glucocorticoid in the management of chronic rhinosinusitis with nasal polyposis].
abstract: OBJECTIVE
  To evaluate the effectiveness of glucocorticoid in the management of olfaction in patients with chronic rhinosinusitis accompanied with nasal polyposis.
  
  
  METHODS
  The published studies of the effectiveness of glucocorticoid in the management of chronic rhinosinusitis with nasal polyposis were searched in the Medline, Cochrane, EMBASE, Springer and CNKI databases(from the date of establishment of the databases to December 2014). The trails selection based on inclusion criteria and the quality of the included studies was assessed and meta-analysis was performed with RevMan 5. 3 software.
  
  
  RESULTS
  A total of 5 trials involving 325 patients were included. The Meta-analysis showed that oral glucocorticoid showed more significant improvement in subjective olfaction scores compared to placebo [SMD = -2.22, 95% CI (-3.94 - -0. 49), P < 0.05], oral glucocorticoid also showed significant improvement in objective olfaction scores compared to placebo [SMD = 0.65, 95% CI (0.28-1.01), P < 0.05]. But subsequent use of nasal glucocorticoid had no impact on subjective and objective olfaction scores [SMD = -2.15, 95% CI (-5.67-1.38), P > 0.05], [SMD = 0.28, 95% CI (-0.08-0.64) P > 0.05].
  
  
  CONCLUSIONS
  According to current evidence, oral glucocorticoid can significantly improve subjective and objective olfaction among patients with CRSwNP, but nasal glucocorticoid cannot improve subjective or objective olfaction dysfunction.
authors.forename: Zewen
authors.initials: Z
authors.lastname: Li
authors.forename: Junyu
authors.initials: J
authors.lastname: Guo
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Fubo
authors.initials: F
authors.lastname: Yan
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Yang
authors.forename: Zhuhua
authors.initials: Z
authors.lastname: Ding
mesh_terms: D002908:Chronic Disease; D002986:Clinical Trials as Topic; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D009298:Nasal Polyps / Q000150:complications / Q000188:drug therapy*; D012852:Sinusitis / Q000150:complications / Q000188:drug therapy*; D012903:Smell / Q000187:drug effects*
chemical_list: D005938:Glucocorticoids