title: [Hereditary gastric and pancreatic cancer predisposition syndromes].
abstract: The most common hereditary gastrointestinal cancers are colorectal, mainly hereditary nonpolyposis colorectal cancer (Lynch syndrome) and familial adenomatous polyposis. Other extracolonic neoplasms, including the gastric and pancreatic adenocarcinomas, are less well known and studied because they account for a relatively small percentage of hereditary gastrointestinal cancers. Nonetheless, they merit special attention because of the high associated morbidity and mortality rates. We review the hereditary and familial syndromes associated with gastric and pancreatic cancers with a view to improving knowledge and understanding of these diseases, in order to heighten diagnostic suspicion and thus implement appropriate diagnostic strategies, screening, surveillance and treatment.
authors.affiliation: Servicio de Gastroenterología, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España.
authors.forename: María Liz
authors.initials: ML
authors.lastname: Leoz
authors.affiliation: Servicio de Gastroenterología, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España.
authors.forename: Ariadna
authors.initials: A
authors.lastname: Sánchez
authors.affiliation: Servicio de Gastroenterología, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España.
authors.forename: Sabela
authors.initials: S
authors.lastname: Carballal
authors.affiliation: Servicio de Gastroenterología, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España.
authors.forename: Lucía
authors.initials: L
authors.lastname: Ruano
authors.affiliation: Servicio de Gastroenterología, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España.
authors.forename: Teresa
authors.initials: T
authors.lastname: Ocaña
authors.affiliation: Servicio de Gastroenterología, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España.
authors.forename: María
authors.initials: M
authors.lastname: Pellisé
authors.affiliation: Servicio de Gastroenterología, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España.
authors.forename: Antoni
authors.initials: A
authors.lastname: Castells
authors.affiliation: Servicio de Gastroenterología, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España.
authors.forename: Francesc
authors.initials: F
authors.lastname: Balaguer
authors.affiliation: Servicio de Gastroenterología, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España. Electronic address: lmoreira@clinic.ub.es.
authors.forename: Leticia
authors.initials: L
authors.lastname: Moreira
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics; D003550:Cystic Fibrosis / Q000150:complications / Q000235:genetics; D055088:Early Detection of Cancer; D016145:Endoscopy, Digestive System; D005260:Female; D005544:Forecasting; D052138:Genes, Neoplasm; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics; D009154:Mutation; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics*; D012306:Risk; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics*
keywords: Cáncer familiar; Cáncer gástrico hereditario; Cáncer pancreático hereditario; Familial cancer; Hereditary gastric cancer; Hereditary pancreatic cancer