title: Donor/Recipient Delta Age: A Possible Risk for Arterial Stenosis in Renal Transplantation.
abstract: Different arterial wall properties can significantly increase the risk of blood turbulent fluxes leading to complications such as atherosclerosis. Since the mechanical properties of arterial vessels are influenced by age, we investigated, in a retrospective study, the effects on renal artery stenosis of an age difference >15 years between donor and recipient in a cohort of 164 patients undergoing renal transplantation between 1981 and 1991. The age difference between donor and recipient was ≤15 years in 87 patients (53.0%) (Group A) and >15 years in 77 patients (47.0%) (Group B, p = ns). None of the Group A patients developed an anastomotic arterial stenosis, whereas 8/77 Group B patients (10.4%) had an anastomotic arterial stenosis (p < 0.001). This study shows that an age difference >15 years is significantly linked to the risk of developing arterial stenosis after renal transplantation. Indeed, different wall properties can significantly increase the risk of generation of blood turbulent fluxes and involve, in the arterial vessels, the development of complications such as atherosclerosis.
authors.affiliation: Faculty of Medicine and Surgery, Department of Physics, University of Bologna, Via Berti Pichat 6/2, 40127 Bologna, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pallotti
authors.affiliation: Nephrology Dialysis and Renal Transplantation Unit, S. Orsola University Hospital, Via Massarenti 9, 40138 Bologna, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Donati
authors.affiliation: Nephrology Dialysis and Renal Transplantation Unit, S. Orsola University Hospital, Via Massarenti 9, 40138 Bologna, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Capelli
authors.affiliation: Nephrology Dialysis and Renal Transplantation Unit, S. Orsola University Hospital, Via Massarenti 9, 40138 Bologna, Italy.
authors.forename: Olga
authors.initials: O
authors.lastname: Baraldi
authors.affiliation: Nephrology Dialysis and Renal Transplantation Unit, S. Orsola University Hospital, Via Massarenti 9, 40138 Bologna, Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Comai
authors.affiliation: Department of Statistical Sciences, University of Bologna, Via Belle Arti 41, 40126 Bologna, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Agati
authors.affiliation: Service of Biostatistics, Niguarda Cà Granda Hospital, Piazza Ospedale Maggiore 3, 20162 Milan, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Nichelatti
authors.affiliation: Nephrology Dialysis and Renal Transplantation Unit, S. Orsola University Hospital, Via Massarenti 9, 40138 Bologna, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cianciolo
authors.affiliation: Nephrology Dialysis and Renal Transplantation Unit, S. Orsola University Hospital, Via Massarenti 9, 40138 Bologna, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: La Manna
mesh_terms: D000328:Adult; D000367:Age Factors; D001696:Biomechanical Phenomena; D015331:Cohort Studies; D019295:Computational Biology; D003251:Constriction, Pathologic; D005260:Female; D006439:Hemodynamics; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012077:Renal Artery / Q000473:pathology / Q000503:physiopathology; D012078:Renal Artery Obstruction / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors