title: Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?
abstract: The present study sought to determine the involvement of median preoptic nucleus (MnPO) in the regulation of the cardiovascular function and renal sympathetic activity in normotensive (NT) and spontaneously hypertensive rats (SHR). MnPO inhibition evoked by Muscimol (4mM) nanoinjections, elicited fall in MAP and renal sympathoinhibition in NT-rats. Surprisingly, in SHRs these responses were greater than in NT-rats. These results demonstrated, for the first time that MnPO was involved in the tonic control of sympathetic activity in NT and SHRs. Furthermore, our data suggest the MnPO involvement in the increased sympathetic outflow and consequent arterial hypertension observed in SHRs.
authors.affiliation: Center for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Aline A
authors.initials: AA
authors.lastname: Mourão
authors.affiliation: Center for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Marina C S
authors.initials: MC
authors.lastname: Moreira
authors.affiliation: Center for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Aryanne B S
authors.initials: AB
authors.lastname: Melo
authors.affiliation: Center for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Paulo R
authors.initials: PR
authors.lastname: Lopes
authors.affiliation: Department of Morphology, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Ana C S
authors.initials: AC
authors.lastname: Rebelo
authors.affiliation: Center for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Rosa
authors.affiliation: Center for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: André H
authors.initials: AH
authors.lastname: Freiria-Oliveira
authors.affiliation: Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Colombari
authors.affiliation: Center for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil. Electronic address: pedrino@ufg.br.
authors.forename: Gustavo R
authors.initials: GR
authors.lastname: Pedrino
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D008845:Microinjections; D009118:Muscimol / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects; D011301:Preoptic Area / Q000187:drug effects / Q000503:physiopathology*; D051381:Rats; D011918:Rats, Inbred SHR; D013564:Sympathetic Nervous System / Q000503:physiopathology*
chemical_list: D009118:Muscimol
keywords: Arterial pressure; Hypertension; MnPO; Renal sympathetic nerve activity; SHR