title: Pharmaceutical nanocrystals confined in porous host systems--interfacial effects and amorphous interphases.
abstract: DSC and NMR results prove the existence of an amorphous acetaminophen nanolayer between acetaminophen nanocrystals (form I and form III) and pore walls in controlled porous glasses. This nanolayer controls the surface energy. This finding is highly relevant for approaches towards crystal engineering in nanopores and indicates similarities to the situation during the early stages of crystallization in polymorphic bulk samples.
authors.affiliation: Martin-Luther-Universität Halle-Wittenberg, Institut für Chemie, Heinrich-Damerow-Str. 4, 06120 Halle (Saale), Germany. beiner@physik.uni-halle.de.
authors.forename: N
authors.initials: N
authors.lastname: Sonnenberger
authors.affiliation: Universität Leipzig, Institut für Technische Chemie, Lineestr. 3, 04103 Leipzig, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Anders
authors.affiliation: Martin-Luther-Universität Halle-Wittenberg, Institut für Physik, Betty-Heimann-Str. 7, 06120 Halle (Saale), Germany.
authors.forename: Y
authors.initials: Y
authors.lastname: Golitsyn
authors.affiliation: Universität Osnabrück, Institut für Chemie neuer Materialien, Barbarastr. 7, 49076 Osnabrück, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Steinhart
authors.affiliation: Universität Leipzig, Institut für Technische Chemie, Lineestr. 3, 04103 Leipzig, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Enke
authors.affiliation: Martin-Luther-Universität Halle-Wittenberg, Institut für Physik, Betty-Heimann-Str. 7, 06120 Halle (Saale), Germany.
authors.forename: K
authors.initials: K
authors.lastname: Saalwächter
authors.affiliation: Martin-Luther-Universität Halle-Wittenberg, Institut für Chemie, Heinrich-Damerow-Str. 4, 06120 Halle (Saale), Germany. beiner@physik.uni-halle.de and Fraunhofer-Institut für Mikrostruktur von Werkstoffen und Systemen IMWS, Walter-Hülse-Str. 1, 06120 Halle (Saale), Germany.
authors.forename: M
authors.initials: M
authors.lastname: Beiner
mesh_terms: D053758:Nanoparticles; D004364:Pharmaceutical Preparations; D013816:Thermodynamics
chemical_list: D004364:Pharmaceutical Preparations