title: New-onset diabetes mellitus after renal transplantation.
abstract: OBJECTIVE
  Diabetes mellitus is a very common metabolic disease with a rising incidence. It is both a leading cause of chronic renal disease and one of the most serious comorbidities in renal transplant recipients. New-onset diabetes after renal transplantation (NODAT) is associated with poor graft function, higher rates of cardiovascular complications and a poor prognosis. The aim of this paper is to review current knowledge of NODAT including risk factors, diagnosis and management.
  
  
  METHODS
  A MEDLINE search was performed to retrieve both original and review articles addressing the epidemiology, risk factors, screening and management of NODAT. We also focused on microRNAs as potential biomarkers of NODAT.
  
  
  CONCLUSIONS
  Understanding the risk factors (both modifiable-e.g. obesity, viruses, and unmodifiable-e.g. age, genetics) may help reduce the incidence and impact of NODAT using pre- and post-transplant management. This can lead to better long-term graft function and general transplant success.
authors.affiliation: Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
authors.forename: Dominika
authors.initials: D
authors.lastname: Goldmannova
authors.affiliation: Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Karasek
authors.affiliation: Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Krystynik
authors.affiliation: Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
authors.forename: Josef
authors.initials: J
authors.lastname: Zadrazil
mesh_terms: D000367:Age Factors; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D020022:Genetic Predisposition to Disease; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D009765:Obesity / Q000150:complications; D011182:Postoperative Care; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D011507:Proteinuria / Q000209:etiology; D044469:Racial Groups; D012307:Risk Factors; D014777:Virus Diseases / Q000150:complications
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents
keywords: NODAT; diabetes mellitus; microRNA; renal transplantation