title: Increased dietary vitamin K intake is associated with less severe subjective memory complaint among older adults.
abstract: OBJECTIVE
  Increased dietary intake of vitamin K, a fat-soluble nutrient involved in brain health and function, has been associated with better cognitive performance in older adults. Our objective was to determine whether the dietary vitamin K intake was associated with the presence and severity of subjective memory complaint among older adults.
  
  
  METHODS
  Observational, cross-sectional cohort study.
  
  
  METHODS
  One hundred sixty older adults taking no vitamin K antagonist were included. The daily dietary vitamin K intake was assessed using a 50-item food frequency questionnaire. The subjective memory complaint was assessed at the same time using the Memory Complaint Questionnaire (MAC-Q; score 0-30, best). Serious subjective memory complaint was defined as MAC-Q score ≤15. Age, gender, body mass index, education level, number of comorbidities, history of stroke, objective cognitive disorders, functional autonomy, mood, serum concentrations of vitamin B12, TSH, albumin, and estimated glomerular filtration rate were used as potential confounders.
  
  
  RESULTS
  Compared to participants without serious subjective memory complaint, those with serious subjective memory complaint (n=110) had a lower mean dietary vitamin K intake (298.0±191.8μg/day versus 393.8±215.2μg/day, P=0.005). Increased log dietary vitamin K intake was positively associated with the MAC-Q score used as a quantitative variable (fully adjusted β=0.79, P=0.031), and inversely with serious subjective memory complaint (fully adjusted OR=0.34, P=0.017).
  
  
  CONCLUSIONS
  Increased dietary vitamin K intake was associated with fewer and less severe subjective memory complaint in older adults taking no vitamin K antagonists. These findings provide epidemiological data supporting future vitamin K replacement trials.
authors.affiliation: Department of Family Medicine, School of Medicine, University of Angers, UNAM, Angers, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Soutif-Veillon
authors.affiliation: Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Quebec, Canada.
authors.forename: Guylaine
authors.initials: G
authors.lastname: Ferland
authors.affiliation: Department of Geriatric Medicine, Institut du Vieillissement, University Hospital; INSERM-U1027, Toulouse, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Rolland
authors.affiliation: Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Quebec, Canada.
authors.forename: Nancy
authors.initials: N
authors.lastname: Presse
authors.affiliation: Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Quebec, Canada.
authors.forename: Kariane
authors.initials: K
authors.lastname: Boucher
authors.affiliation: Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000 Bordeaux, France; INSERM, ISPED, INSERM U897-Epidemiologie-Biostatistique, F-33000 Bordeaux, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Féart
authors.affiliation: Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital; Angers University Memory Clinic; UPRES EA 4638, University of Angers, UNAM, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada. Electronic address: CeAnnweiler@chu-angers.fr.
authors.forename: Cedric
authors.initials: C
authors.lastname: Annweiler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000175:diagnosis*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D011795:Surveys and Questionnaires; D014812:Vitamin K / Q000008:administration & dosage*
chemical_list: D014812:Vitamin K
keywords: Aging; Cognition; Diet; Neuroendocrinology; Subjective memory complaint; Vitamin K