title: The Value of Pre- and Post-Stenting Fractional Flow Reserve for Predicting Mid-Term Stent Restenosis Following Percutaneous Coronary Intervention (PCI).
abstract: Measuring fractional flow reserve (FFR) in percutaneous coronary intervention (PCI) has predictive value for PCI outcome. We decided to examine the utility of pre- and post-stenting FFR as a predictor of 6-month stent restenosis as well as MACE (major adverse cardiac events). Pre- and post-stenting FFR values were measured for 60 PCI patients. Within 6 months after stenting, all patients were followed for assessment of cardiac MACE including myocardial infarction, unstable angina, or positive exercise test. Stent restenosis was also assessed. Cut-off values for pre- and post-stenting FFR measurements were considered respectively as 0.65 and 0.92.Stent restenosis was detected in 4 patients (6.6%). All 4 patients (100%) with restenosis had pre-stenting FFR of < 0.65, while only 26 of 56 patients without restenosis (46.4%) had pre-stenting FFR value of < 0.65 (P= 0.039). Mean pre-stenting FFR in patients with restenosis was significantly lower than in those without restenosis (0.25 ± 0.01 vs. 0.53 ± 0.03, P= 0.022). Although stent restenosis was higher in patients with post-stenting FFR of < 0.92 (2 cases, 9.5%) than in those with FFR value of ≥ 0.92 (2 cases, 5.1%), the difference was not statistically (P= 0.510). Pre-stenting FFR, the use of longer stents, and history of diabetes mellitus can predict stent restenosis, but the value of post-stenting FFR for predicting restenosis was not explicit.
authors.affiliation: . mrsaidi@yahoo.com.
authors.forename: Alireza
authors.initials: A
authors.lastname: Rai
authors.forename: Mostafa
authors.initials: M
authors.lastname: Bahremand
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Saidi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Jalili
authors.forename: Nahid
authors.initials: N
authors.lastname: Salehi
authors.forename: Marzieeh
authors.initials: M
authors.lastname: Assareh
authors.forename: Gholamreza Amini
authors.initials: GA
authors.lastname: Abarghoei
authors.forename: Hashem
authors.initials: H
authors.lastname: Kazerani
mesh_terms: D000328:Adult; D000368:Aged; D023903:Coronary Restenosis / Q000175:diagnosis*; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation*; D011237:Predictive Value of Tests; D012307:Risk Factors; D015607:Stents