title: Ondansetron and Granisetron for prevention of postoperative nausea and vomiting following laparoscopic cholecystectomy.
abstract: BACKGROUND
  Laparoscopic surgeries are known to be associated with a higher incidence of postoperative nausea and vomiting (PONV). Prophylaxis of PONV is usually achieved with a single-dose antiemetic drug administered during the surgical procedure. The aim of this study was to compare the antiemetic efficacy of two different 5-hydroxytryptamine-3 (5HT3) receptor antagonists, ondansetron and granisetron when given prophylactically to patients undergoing laparoscopic cholecystectomy.
  
  
  METHODS
  It was a randomized, double blind study, conducted in 90 patients. Patients were divided into two groups: Group A and Group B with 45 patients in each group. Patients in groupA were given 100 microgram/kg ondansetron intravenously (IV), and patients in Group B were given 40 microgram/kg granisetron. Both the drugs were diluted in 10 ml of 0.9% NaCl and were given at the end of surgery. The standard general anesthetic technique was administered to all the patients. Episodes of nausea, retching and vomiting were assessed during the first 24 hours after anesthesia.
  
  
  RESULTS
  There was no statistically significant difference for demographic data and duration of surgery among the two groups (P>0.05). Evaluated nausea and vomiting scores in the first 3 hours period revealed that each of the drugs had a similar antiemetic effect (P>0.05). Between 4-12 hours also the episodes of nausea, retching as well as vomiting were statistically insignificant in both the groups. In the last 12 hours, episodes of nausea, retching and vomiting were significantly higher in ondansetron group.
  
  
  CONCLUSIONS
  Granisetron, when given prophylactically, resulted in a significantly lower incidence of PONV than ondansetron in the first 24 hours.
authors.affiliation: Department of Anesthesia, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal.
authors.forename: Sabin
authors.initials: S
authors.lastname: Gauchan
authors.affiliation: Department of Anesthesia, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal.
authors.forename: Chitra
authors.initials: C
authors.lastname: Thapa
authors.affiliation: Department of Anesthesia, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Shakya
authors.affiliation: Department of Anesthesia, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Bhattarai
authors.affiliation: Department of Anesthesia, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal.
authors.forename: Sajal
authors.initials: S
authors.lastname: Shakya
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use*; D017081:Cholecystectomy, Laparoscopic; D004311:Double-Blind Method; D005260:Female; D017829:Granisetron / Q000627:therapeutic use*; D006801:Humans; D017294:Ondansetron / Q000627:therapeutic use*; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D017829:Granisetron; D017294:Ondansetron
keywords: granisetron; laparoscopic cholecystectomy; ondansetron; postoperative nausea and vomiting.