title: Disorganization of white matter architecture in major depressive disorder: a meta-analysis of diffusion tensor imaging with tract-based spatial statistics.
abstract: White matter (WM) abnormalities have long been suspected in major depressive disorder (MDD). Tract-based spatial statistics (TBSS) studies have detected abnormalities in fractional anisotropy (FA) in MDD, but the available evidence has been inconsistent. We performed a quantitative meta-analysis of TBSS studies contrasting MDD patients with healthy control subjects (HCS). A total of 17 studies with 18 datasets that included 641 MDD patients and 581 HCS were identified. Anisotropic effect size-signed differential mapping (AES-SDM) meta-analysis was performed to assess FA alterations in MDD patients compared to HCS. FA reductions were identified in the genu of the corpus callosum (CC) extending to the body of the CC and left anterior limb of the internal capsule (ALIC) in MDD patients relative to HCS. Descriptive analysis of quartiles, sensitivity analysis and subgroup analysis further confirmed these findings. Meta-regression analysis revealed that individuals with more severe MDD were significantly more likely to have FA reductions in the genu of the CC. This study provides a thorough profile of WM abnormalities in MDD and evidence that interhemispheric connections and frontal-striatal-thalamic pathways are the most convergent circuits affected in MDD.
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.|Department of Radiology, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan, China.
authors.forename: Guangxiang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Hu
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Huang
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Su
authors.initials: S
authors.lastname: Lui
authors.affiliation: Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Kuang
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, Sichuan, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Ai
authors.affiliation: Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Bi
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, Sichuan, China.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Gu
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.|Department of Psychology, School of Public Administration, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
mesh_terms: D016880:Anisotropy; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000473:pathology; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging* / Q000473:pathology; D056324:Diffusion Tensor Imaging; D006801:Humans; D066127:White Matter / Q000473:pathology*