title: Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells.
abstract: Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play very important immunoregulatory roles in host defense and immune homeostasis. Being anti- and pro-inflammatory in nature, respectively, their functions are antagonistically opposing. A comprehensive and in-depth understanding of their immunological properties and signaling mechanisms will help develop better clinical intervention strategies in therapy for a wide range of human disorders. Here, we provide an update on some emerging concepts, controversies, unanswered questions, and opinions regarding the immune signaling of IL-10 and IL-12.
authors.affiliation: State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, USA; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, USA.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, USA.
authors.forename: Qinglin
authors.initials: Q
authors.lastname: Du
authors.affiliation: State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, USA.
authors.forename: Lixing
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ban
authors.affiliation: State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, USA.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, USA.
authors.forename: Fang
authors.initials: F
authors.lastname: Wei
keywords: IL-10; IL-12; immune signaling