title: A Split-Face Study of the Effects of a Stabilized Hyaluronic Acid-Based Gel of Nonanimal Origin for Facial Skin Rejuvenation Using a Stamp-Type Multineedle Injector: A Randomized Clinical Trial.
abstract: BACKGROUND
  The mid-dermal injection of stabilized hyaluronic acid-based gel of nonanimal origin has been shown to be an effective method for skin rejuvenation. The previous manual technique, using a prefilled syringe, made it difficult to precisely control the injection into the mid-dermal layers and to achieve an even distribution of gel across the area. This single-center, evaluator-blinded, prospective, split-face, randomized controlled trial investigated the efficacy and safety of nonanimal stabilized hyaluronic acid using a stamp-type electronic multineedle injector.
  
  
  METHODS
  Twenty-five patients (aged 27 to 59 years) were recruited into this study. Each participant submitted to a single treatment with a nonanimal stabilized hyaluronic acid injection to one side of the lower cheek. The skin hydration, melanin content, erythema, and elasticity of both cheeks were evaluated at each follow-up visit, at 1, 2, 4, 8, and 12 weeks after treatment.
  
  
  RESULTS
  Stratum corneum hydration was significantly improved after injection. Although no significant improvement was observed at 1 week after treatment, the Corneometer readings for the treated side were significantly higher than those for the untreated the side after the 2-, 4-, 8-, and 12-week treatment visits. Skin elasticity was also significantly improved during the study. The injection had no significant effect on the melanin and erythema indices throughout the follow-up period. The treatment was well tolerated, and no serious adverse events were reported.
  
  
  CONCLUSIONS
  Nonanimal stabilized hyaluronic acid treatment resulted in improved hydration and elasticity of the facial skin. The specialized stamp-type electronic multineedle injector enables the hyaluronic acid filler to rejuvenate the skin effectively and safely.
  
  
  METHODS
  Therapeutic, II.
authors.affiliation: Seoul, Republic of Korea From the Department of Dermatology, Konkuk University School of Medicine, and the Research Institute of Medical Science, Konkuk University.
authors.forename: Nam Kyung
authors.initials: NK
authors.lastname: Roh
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Yang Won
authors.initials: YW
authors.lastname: Lee
authors.forename: Yong Beom
authors.initials: YB
authors.lastname: Choe
authors.forename: Kyu Joong
authors.initials: KJ
authors.lastname: Ahn
mesh_terms: D000328:Adult; D001672:Biocompatible Materials / Q000008:administration & dosage; D000067548:Dermal Fillers / Q000008:administration & dosage*; D004867:Equipment Design; D004954:Esthetics; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007271:Injections, Intradermal / Q000295:instrumentation*; D008875:Middle Aged; D017060:Patient Satisfaction / Q000706:statistics & numerical data*; D011446:Prospective Studies; D012016:Reference Values; D012060:Rejuvenation / Q000502:physiology; D016037:Single-Blind Method; D015595:Skin Aging / Q000187:drug effects*; D018709:Statistics, Nonparametric; D013594:Syringes; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D000067548:Dermal Fillers; D006820:Hyaluronic Acid