title: Rapidly Progressive Transthyretin-Mediated Amyloidosis in a Domino Liver Transplant Recipient of a Ser23Asn Donor.
abstract: Domino liver transplantation, in which the liver of a patient with transthyretin-mediated amyloidosis is transplanted into another patient, has been an established procedure performed at several centers across the world. The risk of developing systemic amyloidosis in transthyretin-mediated amyloidosis liver transplant recipients is a topic of ongoing investigation. We report a case of rapidly progressive transthyretin amyloidosis in a patient who received a liver from a donor with a rare Ser23Asn mutation. We advise exercising caution when considering domino liver transplantation in patients with this particular mutation.
authors.affiliation: *Peripheral Neuropathy Center, Neurological Institute; Departments of †Cardiology; ‡Hematology and Oncology; and §Gastroenterology, Columbia University, College of Physicians and Surgeons, New York, NY.
authors.forename: Neel
authors.initials: N
authors.lastname: Dixit
authors.forename: Adam
authors.initials: A
authors.lastname: Castano
authors.forename: Mary Jane
authors.initials: MJ
authors.lastname: Farr
authors.forename: Rebecca
authors.initials: R
authors.lastname: Traub
authors.forename: Suzanne
authors.initials: S
authors.lastname: Lentzsch
authors.forename: Robert S
authors.initials: RS
authors.lastname: Brown
authors.forename: Mathew S
authors.initials: MS
authors.lastname: Maurer
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Brannagan
mesh_terms: D000328:Adult; D028227:Amyloid Neuropathies, Familial / Q000235:genetics* / Q000601:surgery*; D001216:Asparagine / Q000235:genetics; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D009154:Mutation / Q000235:genetics*; D011228:Prealbumin / Q000235:genetics*; D012694:Serine / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D011228:Prealbumin; D012694:Serine; D001216:Asparagine