title: Association between sleep parameters and cognitive function in drug-naïve children with attention-deficit hyperactivity disorder: a polysomnographic study.
abstract: Sleep problems are common among patients with attention-deficit hyperactivity disorder (ADHD), and are considered major causes of behavioral and cognitive dysfunction in ADHD patients. In the present study, we investigated the relationship between sleep parameters and cognitive function in drug-naïve children with ADHD.
  
  
  
  Twenty-eight patients were recruited to participate in the study, and a polysomnography was used to measure sleep parameters of the subjects. Cognitive measurements were collected, utilizing the Wechsler Intelligence Scale for Children-III (WISC-III), and the Matching Familiar Figure Test for Korean Children (MFFT-KC), while behavioral characteristics of the subjects were assessed using Conners' Global Index-Parent version (CGI-P). Descriptive statistics were calculated for demographic data, sleep parameters, and neurocognitive characteristics of ADHD patients. Spearman's correlation analyses were performed to determine the association between sleep parameters and neurocognitive measures. Moreover, multiple regression analyses were used to identify the best predictors of cognitive function among the various sleep parameters.
  
  
  
  The regression analyses revealed several meaningful correlations, suggesting that slow wave sleep, stage 2 sleep, REM sleep, and limb movement index with arousals (LMAs) as predictors of cognitive function in ADHD patients.
  
  
  
  Based on our study results, sleep parameters and cognitive function were closely associated in ADHD patients; further research should be directed at clarifying this crucial link.
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Yoo Hyun
authors.initials: YH
authors.lastname: Um
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: anton3@catholic.ac.kr.
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Seung-Chul
authors.initials: SC
authors.lastname: Hong
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Tae-Won
authors.initials: TW
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Hyun Kook
authors.initials: HK
authors.lastname: Lim
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Ho-Jun
authors.initials: HJ
authors.lastname: Seo
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Han
mesh_terms: D001143:Arousal; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology*; D002648:Child; D003071:Cognition; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D017286:Polysomnography / Q000379:methods*; D012893:Sleep Wake Disorders; D012895:Sleep, REM / Q000502:physiology*
keywords: ADHD; Cognition; Polysomnography; Sleep