title: Ruthenium photoredox-triggered phospholipid membrane formation.
abstract: As more methodologies for generating and manipulating biomimetic cellular systems are developed, opportunities arise for combining different methods to create more complex synthetic biological constructs. This necessitates an increasing need for tools to selectively trigger individual methodologies. Here we demonstrate ruthenium tris-bipyridine mediated photoredox triggering of the copper catalyzed alkyne azide cycloaddition reaction (CuAAC), resulting in the synthesis of biomimetic phospholipids in situ, and subsequent membrane assembly. The use of a ruthenium-copper electron transport chain to trigger phospholipid assembly opens up future opportunities for spatiotemporal synthesis of membranes.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, CA 92093, USA. ndevaraj@ucsd.edu.
authors.forename: M D
authors.initials: MD
authors.lastname: Hardy
authors.affiliation: Department of Chemical and Biological Engineering, University of Colorado, Boulder, Boulder, CO 80309, USA.
authors.forename: D
authors.initials: D
authors.lastname: Konetski
authors.affiliation: Department of Chemical and Biological Engineering, University of Colorado, Boulder, Boulder, CO 80309, USA.
authors.forename: C N
authors.initials: CN
authors.lastname: Bowman
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, CA 92093, USA. ndevaraj@ucsd.edu.
authors.forename: N K
authors.initials: NK
authors.lastname: Devaraj
mesh_terms: D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000138:chemical synthesis* / Q000737:chemistry; D055668:Photochemical Processes; D011725:Pyridines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D010743:Phospholipids; D011725:Pyridines; D012428:Ruthenium