title: Photodynamic activity of thiophene-derived lysosome-specific dyes.
abstract: The photodynamic activity occurring through the lysosome photo-damage is effective in terms of triggered synergic effects which can avoid chemo-resistance pathways. The potential photodynamic activity of two fluorescent lysosome-specific probes was studied providing their interaction with human serum albumin, demonstrating their in vitro generation of singlet oxygen and investigating the resulted photo-toxic effect in human cancer cells.
authors.affiliation: University of Salento, Biological and Environmental Sciences Department, Via Monteroni, 73100 Lecce, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Baldassarre
authors.affiliation: University of Torino, Department of Drug Science and Technology, Via P. Giuria 9, 10125 Torino, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Foglietta
authors.affiliation: University of Salento, Biological and Environmental Sciences Department, Via Monteroni, 73100 Lecce, Italy.
authors.forename: Viviana
authors.initials: V
authors.lastname: Vergaro
authors.affiliation: University of Torino, Department of Chemistry and NIS Interdepartmental Centre, Via P. Giuria 7, 10125 Torino, Italy.
authors.forename: Nadia
authors.initials: N
authors.lastname: Barbero
authors.affiliation: Institute of Nanotechnology, CNR NANOTEC, Via Monteroni, 73100 Lecce, Italy.
authors.forename: Agostina L
authors.initials: AL
authors.lastname: Capodilupo
authors.affiliation: University of Torino, Department of Drug Science and Technology, Via P. Giuria 9, 10125 Torino, Italy.
authors.forename: Loredana
authors.initials: L
authors.lastname: Serpe
authors.affiliation: University of Torino, Department of Molecular Biotechnology and Health Sciences, Department Innovation Center, Via Quarello 15B, 10135 Torino, Italy.
authors.forename: Sonja
authors.initials: S
authors.lastname: Visentin
authors.affiliation: University of Salento, Department of Cultural Heritage, Via Monteroni, 73100 Lecce, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Tepore
authors.affiliation: University of Salento, Biological and Environmental Sciences Department, Via Monteroni, 73100 Lecce, Italy; Institute of Nanotechnology, CNR NANOTEC, Via Monteroni, 73100 Lecce, Italy. Electronic address: giuseppe.ciccarella@unisalento.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ciccarella
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D008247:Lysosomes / Q000187:drug effects*; D010778:Photochemotherapy; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D011838:Radiation-Sensitizing Agents; D013876:Thiophenes
keywords: Human serum albumin; Lysosomes; Photosensitizers; Reactive oxygen species; Singlet oxygen; Thiophene dyes