title: Adverse effects during the oral glucose tolerance test in post-bariatric surgery patients.
abstract: OBJECTIVE
  The oral glucose tolerance test (OGTT) is used in the screening of gestational diabetes, in diagnosis of type 2 diabetes in conjunction with fasting blood glucose and glycated hemoglobin. The aim of this study was to examine the incidence and risk factors of adverse effects of OGTT in patients who underwent bariatric surgery, in addition to proposing standardization for ordering the OGTT in these patients.
  
  
  METHODS
  This study assessed the incidence of adverse effects in 128 post-bariatric surgery patients who underwent the OGTT. Descriptive and logistic regression analysis were performed, the dependent variables were defined as the presence of signs (tremor, profuse sweating, tachycardia), symptoms (nausea, diarrhea, dizziness, weakness), and hypoglycemia (blood glucose ≤ 50 mg/dL).
  
  
  RESULTS
  One hundred and seventeen participants (91.4%) were female; 38 (29.7%) participants were pregnant. High incidence (64.8%) of adverse effects was observed: nausea (38.4%), dizziness (30.5%), weakness (25.8%), diarrhea (23.4%), hypoglycemia (14.8%), tachycardia (14.1%), tremor (13.3%), profuse sweating (12.5%) and one case of severe hypoglycemia (24 mg/dL). The presence of signs was associated with hypoglycemia (OR = 8.1, CI 95% 2.6-25.1). The arterial hypertension persisted as a risk factor for the incidence of signs (OR = 3.6, CI 95% 1.2-11.3). Fasting glucose below 75 mg/dL increased the risk of hypoglycemia during the test (OR = 9.5, CI 95% 2.6-35.1).
  
  
  CONCLUSIONS
  In this study, high incidence of adverse effects during the OGTT was observed in post-bariatric surgery patients. If these results are confirmed by further studies, the indication and regulation of the OGTT procedure must be reviewed for these patients.
authors.affiliation: Departamento de Clínica Médica, Programa de Pós-Graduação em Ciências Aplicadas à Saúde do Adulto, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
authors.forename: Heliana Fernanda de Albuquerque
authors.initials: HF
authors.lastname: Andrade
authors.affiliation: Departamento de Clínica Médica, Programa de Pós-Graduação em Ciências Aplicadas à Saúde do Adulto, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
authors.forename: William
authors.initials: W
authors.lastname: Pedrosa
authors.affiliation: Departamento de Clínica Médica, Programa de Pós-Graduação em Ciências Aplicadas à Saúde do Adulto, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
authors.forename: Maria de Fátima Haueisen Sander
authors.initials: Mde F
authors.lastname: Diniz
authors.affiliation: Departamento de Clínica Médica, Programa de Pós-Graduação em Ciências Aplicadas à Saúde do Adulto, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
authors.forename: Valéria Maria Azeredo
authors.initials: VM
authors.lastname: Passos
mesh_terms: D000328:Adult; D050110:Bariatric Surgery / Q000009:adverse effects*; D001786:Blood Glucose / Q000032:analysis; D001938:Brazil / Q000453:epidemiology; D003863:Depression / Q000453:epidemiology / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis; D016640:Diabetes, Gestational / Q000175:diagnosis; D050171:Dyslipidemias / Q000453:epidemiology / Q000209:etiology; D005215:Fasting / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology; D007003:Hypoglycemia / Q000453:epidemiology* / Q000209:etiology*; D007037:Hypothyroidism / Q000453:epidemiology / Q000209:etiology; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011184:Postoperative Period; D011247:Pregnancy; D012307:Risk Factors; D013997:Time Factors
chemical_list: D001786:Blood Glucose