title: Nanomedicine Approaches to Modulate Neural Stem Cells in Brain Repair.
abstract: We explore the concept of modulating neural stem cells and their niches for brain repair using nanotechnology-based approaches. These approaches include stimulating cell proliferation, recruitment, and differentiation to functionally recover damaged areas. Nanoscale-engineered materials potentially overcome limited crossing of the blood-brain barrier, deficient drug delivery, and cell targeting.
authors.affiliation: Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal.
authors.forename: Tiago
authors.initials: T
authors.lastname: Santos
authors.affiliation: Biocant - Center of Innovation in Biotechnology, 3060-197 Cantanhede, Portugal.
authors.forename: Carlos
authors.initials: C
authors.lastname: Boto
authors.affiliation: Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal.
authors.forename: Cláudia M
authors.initials: CM
authors.lastname: Saraiva
authors.affiliation: Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal. Electronic address: libernardino@gmail.com.
authors.forename: Liliana
authors.initials: L
authors.lastname: Bernardino
authors.affiliation: Biocant - Center of Innovation in Biotechnology, 3060-197 Cantanhede, Portugal; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal; Instituto de Investigação Interdisciplinar, University of Coimbra, Coimbra, Portugal. Electronic address: lino@biocant.pt.
authors.forename: Lino
authors.initials: L
authors.lastname: Ferreira
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis; D001921:Brain / Q000166:cytology* / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D009416:Nerve Regeneration / Q000187:drug effects*; D058953:Neural Stem Cells / Q000166:cytology* / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials
keywords: brain repair; nanomedicine; nanoparticles; neural stem cells; neurodegenerative diseases; neuronal differentiation