title: Adenosine-Activated Nanochannels Inspired by G-Protein-Coupled Receptors.
abstract: A bioinspired adenosine activated nanodevice is demonstrated in which the conformations of the designed aptamer change and cause signal transmission according to the emergence of adenosine. This bioinspired system exhibits very high response ratios (activated/nonactivated ratio up to 614) and excellent stability and reversibility, and shows promising applications in the fields of biosensors, pharmaceutica, and healthcare systems.
authors.affiliation: Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing, 100191, P. R. China.
authors.forename: Pei
authors.initials: P
authors.lastname: Li
authors.affiliation: Laboratory of Bioinspired Smart Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Xiang-Yu
authors.initials: XY
authors.lastname: Kong
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Ganhua
authors.initials: G
authors.lastname: Xie
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Xiao
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Laboratory of Bioinspired Smart Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Liping
authors.initials: L
authors.lastname: Wen
authors.affiliation: Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing, 100191, P. R. China.|Laboratory of Bioinspired Smart Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry*
chemical_list: D043562:Receptors, G-Protein-Coupled; D004247:DNA; D000241:Adenosine
keywords: adenosine; aptamers; bioinspired; nanochannels; nanodevices