title: Elevated neutrophil-to-lymphocyte ratio is an independent poor prognostic factor in patients with intrahepatic cholangiocarcinoma.
abstract: We investigated whether elevated neutrophil-to-lymphocyte ratio ( NLR ) was associated with poor anti-tumor immunity and prognosis in patients with intrahepatic cholangiocarcinoma ( ICC ). Clinicopathologic data of 102 patients with ICC who underwent hepatectomy was retrospectively analyzed. The Kaplan-Meier method and Cox regression model were used to analyze the survival and prognosis. The percentage of overall lymphocytes , T cells and CD8+ T cells in the high NLR group was lower than that in the low NLR group. The percentage of PD-1+CD4+ and PD-1+CD8+ T cells was higher and the percentage of IFN-γ+CD4+ and IFN-γ+CD8+ T cells was lower in the high NLR group than that in the low NLR group ( p = 0.045, p = 0.008; p = 0.012, p = 0.006 ). Density of tumor-infiltrating CD3+ T cells in the high NLR group was lower than that in the low NLR group ( p < 0.001 ). Elevated NLR was an independent predictor for poor overall survival ( OS; p = 0.035 ) and recurrence-free survival ( RFS; p = 0.008 ). These results indicate that elevated NLR is associated with poor anti-tumor immunity and could be a poor biomarker for prognosis in patients with ICC.
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.|National Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
authors.forename: Guohe
authors.initials: G
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.|Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.|National Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|Department of Endoscopy, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Shuhong
authors.initials: S
authors.lastname: Li
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.|National Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|Department of Hepatobiliary Oncology, Sun-Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Yize
authors.initials: Y
authors.lastname: Mao
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.|National Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|Department of Hepatobiliary Oncology, Sun-Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.|National Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|Department of Hepatobiliary Oncology, Sun-Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Zeyu
authors.initials: Z
authors.lastname: Shuang
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.|National Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|Department of Hepatobiliary Oncology, Sun-Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.|National Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|Department of Hepatobiliary Oncology, Sun-Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Shengping
authors.initials: S
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000276:immunology* / Q000401:mortality; D018281:Cholangiocarcinoma / Q000276:immunology* / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies
keywords: CD4+ T cells; CD8+ T cells; intrahepatic cholangiocarcinoma; neutrophil-to-lymphocyte ratio; prognosis