title: Conjunctival Melanoma With Morphologic Diversity and Orbital Invasion.
abstract: A 68-year-old male with a previous history of 3 dysplastic skin nevi was referred to ophthalmology for a 1-year history of a progressive growth of a firm nodule in the lower left eyelid. Examination revealed a firm nodule in the inferior anterior orbit and mild conjunctival pigmentation on the left inferior fornix. A conjunctival incisional biopsy was taken, showing a melanoma. Because of the infiltration by the mass of the orbit on magnetic resonance imaging, an exenteration was performed. Histopathological analysis showed a unique conjunctival melanoma showing morphological diversity; specifically, a pattern characteristic of conjunctival melanoma, and the concurrent presence of staghorn patterns, signet-ring cells, and rosettoid patterns. Seven years of follow-up shows that the patient is alive with no further metastasis or recurrence. This report represents the first documented case of multiple morphologic patterns within a conjunctival melanoma.
authors.affiliation: Henry C. Witelson Ocular Pathology Laboratory, McGill University Health Centre Research Institute, Montreal, Quebec, Canada.
authors.forename: Pablo
authors.initials: P
authors.lastname: Zoroquiain
authors.forename: Taylor
authors.initials: T
authors.lastname: Nayman
authors.forename: Bruno
authors.initials: B
authors.lastname: Fernandes
authors.forename: Miguel N
authors.initials: MN
authors.lastname: Burnier
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D003230:Conjunctival Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D009361:Neoplasm Invasiveness; D009915:Orbit / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor