title: Use of dextran nanoparticle: A paradigm shift in bacterial exopolysaccharide based biomedical applications.
abstract: This review is a concise compilation of all the major researches on dextran nanoparticle based biomedical applications. Dextran is a highly biocompatible and biodegradable neutral bacterial exopolysaccharide with simple repeating glucose subunits. It's simple yet unique biopolymeric nature made it highly suitable as nanomedicine, nanodrug carrier, and cell imaging system or nanobiosensor. Most importantly, it is extremely water soluble and shows no post drug delivery cellular toxicity. Complete metabolism of dextran is possible inside body thus possibility of renal failure is minimum. Dextran based nanoparticles have superior aqueous solubility, high cargo capacity and intrinsic viscosity, and short storage period. The main focus area of this review is- past and present of major biomedical applications of dextran based nanomaterials thus showing a paradigm shift in bacterial exopolysaccharide based nanobiotechnology.
authors.affiliation: UGC- Centre of Advanced Study, Department of Botany, The University of Burdwan, Golapbag, Bardhaman, 713104 West Bengal, India.
authors.forename: Aparna
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: UGC- Centre of Advanced Study, Department of Botany, The University of Burdwan, Golapbag, Bardhaman, 713104 West Bengal, India. Electronic address: rajibindia@gmail.com.
authors.forename: Rajib
authors.initials: R
authors.lastname: Bandopadhyay
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D003911:Dextrans; D011135:Polysaccharides, Bacterial
keywords: Dextran; Drug delivery; Nanobiosensor