title: Functionalization of poly(ε-caprolactone) surface with lactose-modified chitosan via alkaline hydrolysis: ToF-SIMS characterization.
abstract: Functionalization of poly(ε-caprolactone) (PCL) was performed via hydrolysis and subsequent grafting of lactose-modified chitosan (chitlac) at two different degrees of derivatization (9% and 64%). Time of flight secondary ion mass spectrometry (ToF-SIMS) and multivariate analysis (principal component analysis) were successfully applied to the characterization of PCL surface chemistry, evidencing changes in the biopolymer surface following base-catalyzed hydrolysis treatment. ToF-SIMS analysis also confirmed positive EDC/NHS-catalyzed (EDC: N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide; NHS: N-hydroxysuccinimide) immobilization of chitlac onto activated PCL surface, with formation of amide bonds between PCL surface carboxyl groups and amine residues of chitlac. Yield of grafting reaction was also shown to be dependent upon the lactosilation degree of chitlac.
authors.affiliation: Department of Mathematics and Physics and INFN, Surface Analysis Laboratory, Roma Tre University, Via della Vasca Navale 84, 00146 Rome, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Tortora
authors.affiliation: Department of Mathematics and Physics and INFN, Surface Analysis Laboratory, Roma Tre University, Via della Vasca Navale 84, 00146 Rome, Italy and Department of Engineering, Roma Tre University, Via Vito Volterra 62, 00146 Rome, Italy.
authors.forename: Sofia
authors.initials: S
authors.lastname: Concolato
authors.affiliation: Department of Mathematics and Physics and INFN, Surface Analysis Laboratory, Roma Tre University, Via della Vasca Navale 84, 00146 Rome, Italy and Department of Industrial Engineering, University of Rome "Tor Vergata," Via del Politecnico 1, 00133 Roma, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Urbini
authors.affiliation: Tissue Engineering Unit, "Università Campus Bio-Medico di Roma," via Álvaro del Portillo 21, 00128 Roma, Italy.
authors.forename: Sara Maria
authors.initials: SM
authors.lastname: Giannitelli
authors.affiliation: Tissue Engineering Unit, "Università Campus Bio-Medico di Roma," via Álvaro del Portillo 21, 00128 Roma, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Basoli
authors.affiliation: Tissue Engineering Unit, "Università Campus Bio-Medico di Roma," via Álvaro del Portillo 21, 00128 Roma, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Rainer
authors.affiliation: Tissue Engineering Unit, "Università Campus Bio-Medico di Roma," via Álvaro del Portillo 21, 00128 Roma, Italy.
authors.forename: Marcella
authors.initials: M
authors.lastname: Trombetta
authors.affiliation: Department of Engineering, Roma Tre University, Via Vito Volterra 62, 00146 Roma, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Orsini
authors.affiliation: Tissue Engineering Unit, "Università Campus Bio-Medico di Roma," via Álvaro del Portillo 21, 00128 Roma, Italy.
authors.forename: Pamela
authors.initials: P
authors.lastname: Mozetic
mesh_terms: D048271:Chitosan / Q000032:analysis*; D006868:Hydrolysis; D007785:Lactose / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D018629:Spectrometry, Mass, Secondary Ion
chemical_list: D011091:Polyesters; C016240:polycaprolactone; D048271:Chitosan; D007785:Lactose