title: Re-transplants compared to primary kidney transplants recipients: a mate kidney paired analysis of the OPTN/UNOS database.
abstract: Outcomes of kidney re-transplant recipients (RTR) were compared to primary recipients (FTR) from paired donor kidneys. Organ Procurement and Transplantation Network (OPTN) database was used to identify deceased donors (n = 6266) who donated one kidney to an RTR and the mate kidney to an FTR between January 2000 to December 2010. As compared to FTR, RTR were younger (45 vs. 52 yr, p < 0.001) and had higher proportion of plasma reactive antibody >80 (25% vs 7%, p < 0.001). There were higher 0 mismatches in RTR (19% vs. 16%, p < 0.001). There were more pre-emptive transplants in RTR (24% vs. 21%, p = 0.002). Delayed graft function (28% vs. 25%, p = 0.007) was higher in RTR. Patient survival was similar in FTR and RTR groups at one, three, and five yr (95.7%, 90.2%, and 82.5% vs. 95.2%, 89.8% and 82.7%). Allograft survival rates were higher in FTR group compared to RTR group at one, three, and five yr (91.1%, 82.4%, and 70.9% vs. 87.8%, 77.4%, and 66.1% p < 0.001). Death-censored allograft survival rates were higher in FTR group at one, three, and five yr (91.3%, 82.7% and 71.4% vs. 88%, 77.7% and 66.5% p < 0.001). In today's era of modern immunosuppression, graft survival in RTR has improved but remains inferior to FTR when controlling for donor factors.
authors.affiliation: Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Ali K
authors.initials: AK
authors.lastname: Khalil
authors.affiliation: Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Slaven
authors.affiliation: Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Mujtaba
authors.affiliation: Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Muhammad S
authors.initials: MS
authors.lastname: Yaqub
authors.affiliation: Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Mishler
authors.affiliation: Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Tim E
authors.initials: TE
authors.lastname: Taber
authors.affiliation: Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Asif A
authors.initials: AA
authors.lastname: Sharfuddin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002102:Cadaver; D051799:Delayed Graft Function; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000453:epidemiology*; D006085:Graft Survival; D006801:Humans; D007196:Indiana / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D015995:Prevalence; D011379:Prognosis; D012042:Registries; D012086:Reoperation / Q000706:statistics & numerical data*; D012307:Risk Factors; D009927:Tissue and Organ Procurement; D066027:Transplant Recipients; D055815:Young Adult
keywords: UNOS; kidney; outcomes; recipients; retransplant; transplant