title: Optical Coherence Tomography-Based Quantification of Photoreceptor Injury and Recovery in Vogt-Koyanagi-Harada Uveitis.
abstract: OBJECTIVE
  To determine if the inflammatory composition of subretinal fluid in Vogt-Koyanagi-Harada (VKH) serous retinal detachments is predictive of photoreceptor injury, and to quantify photoreceptor recovery, following resolution of these detachments.
  
  
  METHODS
  Optical density (OD) measurements of spectral-domain optical coherence tomography (SD-OCT) scans were used to derive the fibrinous index, a measure of the inflammatory composition of subretinal fluid. In order to assess photoreceptor status, photoreceptor outer segment (PROS) volume was measured from SD-OCT scans.
  
  
  RESULTS
  The fibrinous index of subretinal fluid in VKH uveitis was strongly correlated with the PROS volume following resolution of subretinal fluid (r = -0.70, p = 0.006). Following fluid resolution, both PROS volume (p < 0.0001) and visual acuity (p = 0.0015) improved.
  
  
  CONCLUSIONS
  The fibrinous index of subretinal fluid during the acute stage of VKH can predict photoreceptor status following resolution of subretinal fluid. PROS volume is a useful measure of photoreceptor recovery in VKH.
authors.affiliation: a Department of Ophthalmology , University of British Columbia , Vancouver , British Columbia , Canada.
authors.forename: Steven S
authors.initials: SS
authors.lastname: Bae
authors.affiliation: b Department of Ophthalmology , St Paul's Hospital , Vancouver , British Columbia , Canada.
authors.forename: Farzin
authors.initials: F
authors.lastname: Forooghian
mesh_terms: D000328:Adult; D005260:Female; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D008297:Male; D015864:Panuveitis / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D020127:Recovery of Function / Q000502:physiology; D012163:Retinal Detachment / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology*; D058471:Subretinal Fluid / Q000378:metabolism; D041623:Tomography, Optical Coherence; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology
chemical_list: D005337:Fibrin
keywords: Optical coherence tomography; Vogt–Koyanagi–Harada; outer segments; photoreceptors; uveitis