title: YAP-Mediated Mechanotransduction in Skeletal Muscle.
abstract: Skeletal muscle is not only translating chemical energy into mechanical work, it is also a highly adaptive and regenerative tissue whose architecture and functionality is determined by its mechanical and physical environment. Processing intra- and extracellular mechanical signaling cues contributes to the regulation of cell growth, survival, migration and differentiation. Yes-associated Protein (YAP), a transcriptional coactivator downstream of the Hippo pathway and its paralog, the transcriptional co-activator with PDZ-binding motif (TAZ), were recently found to play a key role in mechanotransduction in various tissues including skeletal muscle. Furthermore, YAP/TAZ modulate myogenesis and muscle regeneration and abnormal YAP activity has been reported in muscular dystrophy and rhabdomyosarcoma. Here, we summarize the current knowledge of mechanosensing and -signaling in striated muscle. We highlight the role of YAP signaling and discuss the different routes and hypotheses of its regulation in the context of mechanotransduction.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Center for Research in Myology, Sorbonne Universités Université Pierre et Marie Curie University Paris 06Paris, France; Institute of Chemistry and Biochemistry, Freie Universität BerlinBerlin, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: Fischer
authors.affiliation: Institute of Chemistry and Biochemistry, Freie Universität BerlinBerlin, Germany; Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin BerlinBerlin, Germany.
authors.forename: Paul
authors.initials: P
authors.lastname: Rikeit
authors.affiliation: Institute of Chemistry and Biochemistry, Freie Universität Berlin Berlin, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Knaus
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Center for Research in Myology, Sorbonne Universités Université Pierre et Marie Curie University Paris 06 Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Coirault
keywords: YAP; hippo pathway; mechanotransduction; muscle homeostasis; skeletal muscle