title: Effects of Transient Versus Chronic Loneliness on Cognitive Function in Older Adults: Findings From the Chinese Longitudinal Healthy Longevity Survey.
abstract: Loneliness is a risk factor for poor cognitive function in older adults (OAs); to date, however, no studies have explored whether transient and chronic loneliness have differential effects on OAs' cognitive function. The present study evaluates the impacts of transient versus chronic loneliness on cognitive function in OAs.
  
  
  
  A 6-year follow-up cohort study.
  
  
  
  Rural and urban communities of 22 provinces in China.
  
  
  
  2,995 OAs who were cognitively healthy (the modified Mini-Mental State Examination [mMMSE] ≥ 14) and completed the 2005, 2008, and 2011 waves of the Chinese Longitudinal Healthy Longevity Survey.
  
  
  
  Self-report loneliness and mMMSE.
  
  
  
  Both transient (β = -0.389, t = -2.191, df = 2994, p = 0.029) and chronic loneliness (β = -0.640, t = -2.109, df = 2994, p = 0.035) were significantly associated with lower mMMSE scores 6 years later, net of potential confounding effects of baseline covariates. Sensitivity analyses found that regression coefficients of mMMSE scores on transient loneliness were statistically significant and relatively stable across samples with various levels of cognitive function. In contrast, coefficients of mMMSE scores on chronic loneliness were statistically significant only among samples with normal cognitive function and the absolute values of these coefficients increased with the degree of cognitive health of the analytic sample. In the sample with mMMSE greater than or equal to 21, the coefficient of chronic loneliness was 2.59 times as large as that of transient loneliness (-1.017 versus -0.392).
  
  
  
  Both transient and chronic loneliness are significant predictors of cognitive decline in OAs. Relative to transient loneliness, chronic loneliness has more pronounced negative effects on the brain health of OAs.
authors.affiliation: Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA; The Affiliated Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China.
authors.forename: Bao-Liang
authors.initials: BL
authors.lastname: Zhong
authors.affiliation: Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA; Department of Psychology, Zhejiang University, Hangzhou, China.
authors.forename: Shu-Lin
authors.initials: SL
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: Yeates_Conwell@URMC.Rochester.edu.
authors.forename: Yeates
authors.initials: Y
authors.lastname: Conwell
mesh_terms: D000368:Aged; D002681:China / Q000453:epidemiology; D060825:Cognitive Dysfunction / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008132:Loneliness / Q000523:psychology*; D008137:Longitudinal Studies; D008297:Male; D012424:Rural Population / Q000706:statistics & numerical data*; D014505:Urban Population / Q000706:statistics & numerical data*
keywords: China; cognitive function; dementia; loneliness; older adults; prevention