title: Determinants of quality of life among long-term breast cancer survivors.
abstract: To identify the impact of clinical and socio-economic determinants on quality of life (QoL) among breast cancer (BC) survivors 5 years after diagnosis.
  
  
  
  A cross-sectional survey was conducted in women diagnosed in 2007 for primary invasive non-metastatic BC and identified through the Côte d'Or BC registry. QoL was assessed with the Medical Outcomes Study 12-item Short Form Health Survey (SF-12), the European Organization for Research and Treatment of Cancer Quality of Life (EORTC-QLQ-C30) and the breast cancer (EORTC-QLQ-BR23) questionnaires. Social support was assessed with Sarason's social support questionnaire, and deprivation was assessed by the EPICES questionnaire. Clinical variables were collected through the registry database. Determinants of QoL were identified using multivariable mixed model analysis for each SF-12 dimension. A sensitivity analysis was conducted with multiple imputations on missing data.
  
  
  
  Overall, 188 patients on 319 patients (59 %) invited to participate to the survey completed the questionnaires. Five years after breast cancer diagnosis, the disease stages at diagnosis, as well as the treatment received, were not determinants of QoL. Only the age at diagnosis and comorbidities were found to be determinants of QoL.
  
  
  
  Five years after BC diagnosis, disease severity and the treatment received did not affect QoL.
authors.affiliation: Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France.|EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France.
authors.forename: Wai-On
authors.initials: WO
authors.lastname: Chu
authors.affiliation: Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France.|EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France.
authors.forename: Pegdwende Olivia
authors.initials: PO
authors.lastname: Dialla
authors.affiliation: Pathology Centre, 33 rue Nicolas Bornier, 21000, Dijon, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Roignot
authors.affiliation: Centre Radiotherapie du Parc, 18 cours du General de Gaulle, 21000, Dijon Cedex, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Bone-Lepinoy
authors.affiliation: Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France.|EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Poillot
authors.affiliation: Department of Surgical Oncology, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Coutant
authors.affiliation: Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France.|EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Arveux
authors.affiliation: EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France. sdabakuyo@cgfl.fr.|Biostatistics and Quality of Life Unit, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France. sdabakuyo@cgfl.fr.|National Quality of Life and Cancer Clinical Research Platform, Dijon, France. sdabakuyo@cgfl.fr.
authors.forename: Tienhan Sandrine
authors.initials: TS
authors.lastname: Dabakuyo-Yonli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000523:psychology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D017741:Survivors
keywords: Breast cancer; Determinant of quality of life; Long-term survivor; Social support; Socio-economics factors