title: Antifungal Lock Therapy with Liposomal Amphotericin B: A Prospective Trial.
abstract: We conducted a prospective pilot study to evaluate the potential role of combined systemic antifungal and liposomal amphotericin B lock therapy in children with intestinal insufficiency with fungal catheter-related bloodstream infections whose central venous catheters had not been removed. Our results provide supportive evidence for the conduct of larger clinical trials to confirm the efficacy and safety of this approach.
authors.affiliation: Department of Pharmacy, Children's Hospital of Pittsburgh Department of Pharmacy and Therapeutics, University of Pittsburgh Pharmacy School.
authors.forename: William
authors.initials: W
authors.lastname: McGhee
authors.affiliation: Department of Infectious Diseases, Children's Hospital of Pittsburgh Department of Infectious Diseases, University of Pittsburgh Medical School.
authors.forename: Marian G
authors.initials: MG
authors.lastname: Michaels
authors.affiliation: Department of Infectious Diseases, Children's Hospital of Pittsburgh Department of Infectious Diseases, University of Pittsburgh Medical School.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Martin
authors.affiliation: Department of Transplant Surgery, Children's Hospital of Pittsburgh Department of Transplant Surgery, University of Pittsburgh Medical School.
authors.forename: George V
authors.initials: GV
authors.lastname: Mazariegos
authors.affiliation: Department of Infectious Diseases, Children's Hospital of Pittsburgh Department of Infectious Diseases, University of Pittsburgh Medical School.
authors.forename: Michael
authors.initials: M
authors.lastname: Green
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D055499:Catheter-Related Infections / Q000150:complications / Q000188:drug therapy*; D062905:Central Venous Catheters / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007410:Intestinal Diseases / Q000150:complications; D000072742:Invasive Fungal Infections / Q000188:drug therapy*; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B
keywords: Central line; fungal infections; liposomal Amphotericin B; liposomal lock therapy