title: Construction of polycythemia vera protein interaction network and prediction of related biological functions.
abstract: Here, polycythemia vera (PV)-related genes were screened by the Online Mendelian Inheritance in Man (OMIM), and literature pertaining to the identified genes was extracted and a protein-protein interaction network was constructed using various Cytoscape plugins. Various molecular complexes were detected using the Clustervize plugin and a gene ontology-enrichment analysis of the biological pathways, molecular functions, and cellular components of the selected molecular complexes were identified using the BiNGo plugin. Fifty-four PV-related genes were identified in OMIM. The protein-protein interaction network contains 5 molecular complexes with correlation integral values >4. These complexes regulated various biological processes (peptide tyrosinase acidification, cell metabolism, and macromolecular biosynthesis), molecular functions (kinase activity, receptor binding, and cytokine activity), and the cellular components were mainly concentrated in the nucleus, intracellular membrane-bounded organelles, and extracellular region. These complexes were associated with the JAK-STAT signal transduction pathway, neurotrophic factor signaling pathway, and Wnt signaling pathway, which were correlated with chronic myeloid leukemia and acute myeloid leukemia.
authors.affiliation: Cancer Center, Weifang Traditional Chinese Medicine Hospital, Kuiwen District, Weifang, Shandong Province, China.
authors.forename: L-J
authors.initials: LJ
authors.lastname: Liu
authors.affiliation: The First Clinical College, Shandong University of Chinese Medicine, Changqing District, Jinan, Shandong Province, China.
authors.forename: X-J
authors.initials: XJ
authors.lastname: Cao
authors.affiliation: Cancer Center, Weifang Traditional Chinese Medicine Hospital, Kuiwen District, Weifang, Shandong Province, China.
authors.forename: C
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Clinical Medical School, Weifang Medical University, Kuiwen District, Weifang, Shandong Province, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Clinical Medical School, Weifang Medical University, Kuiwen District, Weifang, Shandong Province, China.
authors.forename: Q-L
authors.initials: QL
authors.lastname: Lv
authors.affiliation: Cancer Center, Weifang Traditional Chinese Medicine Hospital, Kuiwen District, Weifang, Shandong Province, China.
authors.forename: F-B
authors.initials: FB
authors.lastname: Feng
authors.affiliation: China Academy of Traditional Chinese Medicine, Dongcheng District, Beijing, China.
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Zhang
authors.affiliation: Cancer Center, Weifang Traditional Chinese Medicine Hospital, Kuiwen District, Weifang, Shandong Province, China.
authors.forename: C-G
authors.initials: CG
authors.lastname: Sun
mesh_terms: D030541:Databases, Genetic; D005786:Gene Expression Regulation; D063990:Gene Ontology; D053263:Gene Regulatory Networks; D006801:Humans; D053613:Janus Kinase 1 / Q000235:genetics / Q000378:metabolism; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D058977:Molecular Sequence Annotation; D011087:Polycythemia Vera / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D025941:Protein Interaction Mapping; D050791:STAT Transcription Factors / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D050791:STAT Transcription Factors; D051153:Wnt Proteins; C507904:JAK1 protein, human; D053613:Janus Kinase 1