title: Elevated circulating sST2 associated with subclinical atherosclerosis in newly diagnosed primary hypertension.
abstract: The aims of this study were to measure the levels of interleukin-33 (IL-33) and soluble Suppression of Tumorigenicity 2 (sST2) in patients with newly diagnosed primary hypertension (HT) and to determine the relationship between carotid intima-media thickness (CIMT) and IL-33/sST2. Eighty-two patients with newly diagnosed primary HT and ninety healthy volunteers were included in the study. CIMT ⩾0.9 mm was considered as significant for subclinical atherosclerosis. The sST2 levels of patients with primary HT were higher than those of the control group, whereas the IL-33 levels of these patients were much lower than those of the control group. The sST2 levels were higher in patients with subclinical atherosclerosis than in control subjects or patients with primary HT but not with subclinical atherosclerosis. In the primary HT group, sST2 had a positive correlation with CIMT, 24-h systolic-diastolic blood pressure, low-density lipoprotein and C-reactive protein, whereas sST2 had a negative correlation with the IL-33 level. A stepwise multivariable logistic regression analysis revealed that sST2 is an independent risk factor for subclinical atherosclerosis. Although the diagnostic predictive value of HT risk was determined as >51.8 pg l(-1) in the receiver operating characteristic curve analysis in respect of the sST2 level, the diagnostic predictive value for subclinical atherosclerosis risk was determined to be >107.2 pg l(-1). The sST2 level displays a positive correlation with atherosclerotic changes, and is an independent risk factor for subclinical atherosclerosis expressed as increased CIMT.
authors.affiliation: Department of Internal Medicine, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ates
authors.affiliation: Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Ozkayar
authors.affiliation: Department of Immunology and Allergy, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
authors.forename: Hale
authors.initials: H
authors.lastname: Ates
authors.affiliation: Department of Cardiology, Ankara Occupational Diseases Hospital, Ankara, Turkey.
authors.forename: Uğur Nadir
authors.initials: UN
authors.lastname: Karakulak
authors.affiliation: Department of Neurology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Oğuzhan
authors.initials: O
authors.lastname: Kursun
authors.affiliation: Department of Biochemistry, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Topcuoglu
authors.affiliation: Department of Internal Medicine, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Bayram
authors.initials: B
authors.lastname: Inan
authors.affiliation: Department of Internal Medicine, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Nisbet
authors.initials: N
authors.lastname: Yilmaz
mesh_terms: D050197:Atherosclerosis / Q000150:complications / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D000067596:Interleukin-33 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017481:Receptors, Somatostatin / Q000097:blood*; D012307:Risk Factors
chemical_list: C506536:IL33 protein, human; D000067596:Interleukin-33; D017481:Receptors, Somatostatin; C106140:somatostatin receptor sst2A