title: Psychosocioeconomic Precariousness, Cognitive Decline and Risk of Developing Dementia: A 25-Year Study.
abstract: This study investigates the relationship between psychosocioeconomic precariousness, cognitive decline and risk of developing dementia.
  
  
  
  The sample consisted of 3,710 subjects aged ≥65 years. Psychosocioeconomic precariousness was assessed with a ratio consisting of 8 self-reported items of poor socioeconomic status and psychosocial vulnerability.
  
  
  
  Participants who were considered as precarious (n = 1,444) presented greater cognitive decline (β = -0.07; p = 0.0067) after adjusting for various confounders. They also had a 36% increased risk of developing dementia (hazard ratio 1.36, 95% confidence interval 1.17-1.57; p < 0.0001) over the 25-year follow-up period.
  
  
  
  Psychosocioeconomic precariousness is associated with greater cognitive decline and increased risk of developing dementia. This relationship can be explained in light of the concept of cognitive reserve and strengthens the need to consider psychosocioeconomic precariousness of elderly individuals in the definition of successful ageing policies.
authors.affiliation: INSERM, U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Ouvrard
authors.forename: Céline
authors.initials: C
authors.lastname: Meillon
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dartigues
authors.forename: José Alberto
authors.initials: JA
authors.lastname: Ávila-Funes
authors.forename: Hélène
authors.initials: H
authors.lastname: Amieva
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D060825:Cognitive Dysfunction / Q000523:psychology*; D003704:Dementia / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D057566:Self Report; D012959:Socioeconomic Factors