title: Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo.
abstract: Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative Zeta potential and shown to be spherical in shape. The loading efficiency of superparamagnetic iron oxide nanoparticles in the m-NC was ~100%. Up to ~3- and ~2.2-fold increase in tumour uptake at 1 and 24 h was achieved, when a static magnetic field was applied to the tumour for 1 hour. m-NCs, with multiple imaging probes (e.g. indocyanine green, superparamagnetic iron oxide nanoparticles and indium-111), were capable of triple-modal imaging (fluorescence/magnetic resonance/nuclear imaging) in vivo. Using triple-modal imaging is to overcome the intrinsic limitations of single modality imaging and provides complementary information on the spatial distribution of the nanocarrier within the tumour. The significant findings of this study could open up new research perspectives in using novel magnetically-responsive nanomaterials in magnetic-drug targeting combined with multi-modal imaging.
authors.affiliation: 1. Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, London, SE1 9NH, UK.
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
authors.affiliation: 1. Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, London, SE1 9NH, UK.
authors.forename: Julie T-W
authors.initials: JT
authors.lastname: Wang
authors.affiliation: 1. Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, London, SE1 9NH, UK.
authors.forename: Noelia
authors.initials: N
authors.lastname: Rubio
authors.affiliation: 2. Cardiovascular Division, James Black Centre, King's College London British Heart Foundation Centre of Excellence, London, SE5 9NU, UK.
authors.forename: Andrea
authors.initials: A
authors.lastname: Protti
authors.affiliation: 3. Electron Microscopy for Materials Research (EMAT), University of Antwerp, Groenenborgerlaan 171, B-2020, Antwerp, Belgium.
authors.forename: Hamed
authors.initials: H
authors.lastname: Heidari
authors.affiliation: 4. Faculty of Pharmacy, Ain Shams University, Khalifa El-Maamon Street, Abbasiya Square, Cairo, 11566, Egypt.
authors.forename: Riham
authors.initials: R
authors.lastname: Elgogary
authors.affiliation: 5. UCL Healthcare Biomagnetics Laboratory, University College London, 21 Albemarle Street, London, W1S 4BS, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Southern
authors.affiliation: 6. School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
authors.forename: Wafa' T
authors.initials: WT
authors.lastname: Al-Jamal
authors.affiliation: 7. Centre for Molecular Oncology, Bart's Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
authors.forename: Jane
authors.initials: J
authors.lastname: Sosabowski
authors.affiliation: 2. Cardiovascular Division, James Black Centre, King's College London British Heart Foundation Centre of Excellence, London, SE5 9NU, UK.
authors.forename: Ajay M
authors.initials: AM
authors.lastname: Shah
authors.affiliation: 3. Electron Microscopy for Materials Research (EMAT), University of Antwerp, Groenenborgerlaan 171, B-2020, Antwerp, Belgium.
authors.forename: Sara
authors.initials: S
authors.lastname: Bals
authors.affiliation: 5. UCL Healthcare Biomagnetics Laboratory, University College London, 21 Albemarle Street, London, W1S 4BS, UK.
authors.forename: Quentin A
authors.initials: QA
authors.lastname: Pankhurst
authors.affiliation: 1. Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, London, SE1 9NH, UK.
authors.forename: Khuloud T
authors.initials: KT
authors.lastname: Al-Jamal
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage*; D008280:Magnetics; D008807:Mice, Inbred BALB C; D064847:Multimodal Imaging / Q000379:methods*; D053769:Nanocapsules / Q000008:administration & dosage*; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology*
chemical_list: D005290:Ferric Compounds; D053769:Nanocapsules; C000499:ferric oxide
keywords: PEGylated PLGA; magnetic resonance imaging; magnetic targeting; nuclear imaging; optical imaging