title: Sedative effect of central administration of Coriandrum sativum essential oil and its major component linalool in neonatal chicks.
abstract: Context Coriandrum sativum L. (Apiaceae) (coriander) is an herb grown throughout the world as a culinary, medicinal or essential crop. In traditional medicine, it is used for the relief of anxiety and insomnia. Systemic hydro-alcoholic and aqueous extract from aerial parts and seeds had anxiolytic and sedative action in rodents, but little is known about its central effect in chicks. Objective To study the effects of intracerebroventricular administration of essential oil from coriander seeds and its major component linalool on locomotor activity and emotionality of neonatal chicks. Materials and methods The chemical composition of coriander essential oil was determined by a gas-chromatographic analysis (> 80% linalool). Behavioural effects of central administration of coriander oil and linalool (both at doses of 0.86, 8.6 and 86 μg/chick) versus saline and a sedative diazepam dose (17.5 μg/chick, standard drug) in an open field test for 10 min were observed. Results Doses of 8.6 and 86 μg from coriander oil and linalool significantly decreased (p < 0.05) squares crossed number, attempted escapes, defecation number and distress calls, and significantly increased (p < 0.05) the sleeping posture on an open field compared with saline and were similar to the diazepam group. Discussion and conclusion The results indicate that intracerebroventricular injection of essential oil from Coriandrum sativum seeds induced a sedative effect at 8.6 and 86 μg doses. This effect may be due to monoterpene linalool, which also induced a similar sedative effect, and, therefore, could be considered as a potential therapeutic agent similar to diazepam.
authors.affiliation: a Departamento De Química, Facultad De Ciencias Exactas, Físicas Y Naturales , Universidad Nacional De Córdoba. Instituto De Investigaciones Biológicas Y Tecnológicas, IIByT (CONICET - UNC) , Córdoba , Argentina ;
authors.forename: María Soledad
authors.initials: MS
authors.lastname: Gastón
authors.affiliation: a Departamento De Química, Facultad De Ciencias Exactas, Físicas Y Naturales , Universidad Nacional De Córdoba. Instituto De Investigaciones Biológicas Y Tecnológicas, IIByT (CONICET - UNC) , Córdoba , Argentina ;
authors.forename: Mariana Paula
authors.initials: MP
authors.lastname: Cid
authors.affiliation: b Laboratorio De Tecnología Química, Facultad De Ciencias Químicas , Universidad Católica De Córdoba , Córdoba , Argentina ;
authors.forename: Ana María
authors.initials: AM
authors.lastname: Vázquez
authors.affiliation: b Laboratorio De Tecnología Química, Facultad De Ciencias Químicas , Universidad Católica De Córdoba , Córdoba , Argentina ;
authors.forename: María Florencia
authors.initials: MF
authors.lastname: Decarlini
authors.affiliation: b Laboratorio De Tecnología Química, Facultad De Ciencias Químicas , Universidad Católica De Córdoba , Córdoba , Argentina ;
authors.forename: Gabriela I
authors.initials: GI
authors.lastname: Demmel
authors.affiliation: c Departamento De Química Orgánica, Facultad De Ciencias Químicas , Universidad Nacional De Córdoba. Instituto De Investigaciones En Físico-Química De Córdoba, INFICQ (CONICET - UNC) , Córdoba , Argentina ;
authors.forename: Laura I
authors.initials: LI
authors.lastname: Rossi
authors.affiliation: d Departamento De Química, Facultad De Ciencias Exactas, Físicas Y Naturales , Universidad Nacional De Córdoba Córdoba , Argentina.
authors.forename: Mario Leandro
authors.initials: ML
authors.lastname: Aimar
authors.affiliation: a Departamento De Química, Facultad De Ciencias Exactas, Físicas Y Naturales , Universidad Nacional De Córdoba. Instituto De Investigaciones Biológicas Y Tecnológicas, IIByT (CONICET - UNC) , Córdoba , Argentina ;
authors.forename: Nancy Alicia
authors.initials: NA
authors.lastname: Salvatierra
mesh_terms: D000080462:Acyclic Monoterpenes; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D002645:Chickens; D028526:Coriandrum / Q000737:chemistry; D003975:Diazepam / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects*; D005260:Female; D005410:Flame Ionization; D008401:Gas Chromatography-Mass Spectrometry; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000302:isolation & purification; D007276:Injections, Intraventricular; D008297:Male; D039821:Monoterpenes / Q000008:administration & dosage* / Q000302:isolation & purification; D009043:Motor Activity / Q000187:drug effects*; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000302:isolation & purification; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage* / Q000302:isolation & purification; D010946:Plants, Medicinal; D012639:Seeds
chemical_list: D000080462:Acyclic Monoterpenes; D006993:Hypnotics and Sedatives; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; C018584:linalool; D003975:Diazepam
keywords: Coriander; i.c.v. injection; locomotor behavior; sedation