title: [Cogan syndrome – when several of our senses are affected].
abstract: Cogans syndrome is a rare systemic inflammatory disease characterized by a combination of audiovestibular and ocular symptoms. In some cases, systemic complications occur with vascular inflammation. Aortitis and large vessel vasculitis are the most common forms, but medium-sized and small vessel involvement has also been described. The autoimmune reaction can lead to blindness, deafness and in worst case death, if these patients remain untreated or if treatment is delayed. There is no specific blood test or imaging method available and the diagnosis is clinical. It should be suspected in patients presenting with both inflammatory eye symptoms and audiovestibular dysfunction, when more common autoimmune and infectious diseases have been excluded. The treatment consists of high dose systemic steroids, topical steroids for the affected eye and in some cases addition of immunosuppressive drugs. Treatment is based on the severity of the symptoms and how well the patient responds to initial systemic corticosteroids. Here we present a case of suspected Cogan's syndrome where diagnosis was considered after exclusion of other possible autoimmune and infectious diseases.
authors.affiliation: underläkare, Centralsjukhuset Karlstad - öron-, näsa- och halskliniken Karlstad, Sweden Centralsjukhuset Karlstad - ÖNH-kliniken Karlstad, Sweden.
authors.forename: Erika
authors.initials: E
authors.lastname: Hedin
authors.affiliation: överläkare, Centralsjukhuset Karlstad - öron-, näsa- och halskliniken Karlstad, Sweden överläkare, Centralsjukhuset Karlstad - öron-, näsa- och halskliniken Karlstad, Sweden.
authors.forename: Helge
authors.initials: H
authors.lastname: Lyckberg
authors.affiliation: med dr, överläkare, Centralsjukhuset Karlstad - öron-, näsa- och halskliniken Karlstad, Sweden med dr, överläkare, Centralsjukhuset Karlstad - öron-, näsa- och halskliniken Karlstad, Sweden.
authors.forename: Per-Inge
authors.initials: PI
authors.lastname: Carlsson
mesh_terms: D001299:Audiometry; D055952:Cogan Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D003348:Cortisone / Q000627:therapeutic use; D005260:Female; D046088:Hearing Loss, Unilateral / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007500:Iritis / Q000188:drug therapy / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014717:Vertigo / Q000209:etiology
chemical_list: D007166:Immunosuppressive Agents; D003348:Cortisone