title: [Research Advances of A New Co-stimulatory Molecule-B7 Homolog 6--Review].
abstract: B7-H6 is a co-stimulatory molecule discoveried recently. B7-H6 is not expressed on normal cells, but specially expressed on tumor cells. It can also be expressed on antigen presenting cells (APC) by the induction. The B7-H6 expression can be downregulated by HDACi. NK cells can be activated to release TNFα and IFNγ through B7H6-NKp30 pathway. The B7-H6 molecules expressed on the cell surface can be shedded to form soluble molecules. In the meantime, the B7-H6/NKp30 pathway may be involved in the pathogenesis of primary Sjogren syndrome. B7-H6/NKp30 may become a new therapeutic target for tumor, inflammation and autoimmune diseases. This review discusses the B7-H6 and receptor sructure, the expression and significance of B7-H6, the function and regulating mechanism of B7-H6 and the soluble molecules of B7-H6.
authors.affiliation: Department of Hematology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Wu
authors.affiliation: Department of Hematology, Peking University Third Hospital, Beijing 100191, China. E-mail: xiaoyank@yahoo.com.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Ke
mesh_terms: D001327:Autoimmune Diseases; D060887:B7 Antigens / Q000378:metabolism*; D015536:Down-Regulation; D006801:Humans; D007249:Inflammation; D007694:Killer Cells, Natural / Q000378:metabolism; D055628:Natural Cytotoxicity Triggering Receptor 3 / Q000378:metabolism*; D009369:Neoplasms
chemical_list: D060887:B7 Antigens; C542363:NCR3LG1 protein, human; D055628:Natural Cytotoxicity Triggering Receptor 3