title: Contrasting roles of Ih and the persistent sodium current at subthreshold voltages during naturalistic stimuli.
abstract: The subthreshold activity of hippocampal CA1 pyramidal neurons is regulated by the persistent sodium current (INaP) and the h-current (Ih), carried by tetrodotoxin-sensitive sodium channels and hyperpolarization-activated cyclic-nucleotide-gated channels, respectively. Recently, Yamada-Hanff and Bean (J Neurophysiol 114: 2376-2389, 2015) used pharmacological methods to discern the roles of Ihand INaPat subthreshold voltages during naturalistic stimuli. We discuss these findings in the context of dorsoventral heterogeneity in the hippocampus and suggest further applications of the method.
authors.affiliation: Department of Molecular Neuroscience, University College London Institute of Neurology, London, United Kingdom; and.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Thor
authors.affiliation: Department of Clinical and Experimental Epilepsy, University College London Institute of Neurology, London, United Kingdom gareth.morris@ucl.ac.uk.
authors.forename: Gareth
authors.identifier: 0000-0003-2469-5102
authors.initials: G
authors.lastname: Morris
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D006801:Humans; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology*
chemical_list: D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D015222:Sodium Channels
keywords: h-current; hippocampus; sodium current; subthreshold