title: Herpes Virus Infections During Treatment With Etanercept in Juvenile Idiopathic Arthritis.
abstract: Incidence rates for varicella and herpes zoster were similar in patients with juvenile idiopathic arthritis receiving etanercept/methotrexate (n = 85, 184.9 patient-years [PY]) or methotrexate alone (n = 71, 199.4 PY); no complicated varicella or herpes zoster cases were reported; herpes labialis incidence was higher in patients receiving etanercept/methotrexate versus methotrexate alone (0.38 vs. 0.24 PY).
authors.affiliation: Division of Rheumatology.
authors.forename: R
authors.initials: R
authors.lastname: Nicolai
authors.affiliation: Division of Pediatrics, Ospedale Santa Maria della Stella, Orvieto, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Cortis
authors.affiliation: Division of Epidemiology, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Ravà
authors.affiliation: Division of Rheumatology.
authors.forename: C
authors.initials: C
authors.lastname: Bracaglia
authors.affiliation: Division of Rheumatology.
authors.forename: M
authors.initials: M
authors.lastname: Pardeo
authors.affiliation: Division of Rheumatology.
authors.forename: A
authors.initials: A
authors.lastname: Insalaco
authors.affiliation: Division of Rare Diseases, Department of Pediatric Medicine.
authors.forename: P S
authors.initials: PS
authors.lastname: Buonuomo
authors.affiliation: Division of Epidemiology, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
authors.forename: A E
authors.initials: AE
authors.lastname: Tozzi
authors.affiliation: Division of Rheumatology.
authors.forename: F
authors.initials: F
authors.lastname: De Benedetti
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D002644:Chickenpox / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D000068800:Etanercept / Q000627:therapeutic use*; D005260:Female; D006560:Herpes Labialis / Q000453:epidemiology*; D006562:Herpes Zoster / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D012384:Rome / Q000453:epidemiology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept; D008727:Methotrexate
keywords: etanercept; herpes simplex virus; juvenile idiopathic arthritis; varicella zoster virus