title: Post-transplant lymphoproliferative disorder in paediatric patients: the Irish perspective-a single centre experience.
abstract: BACKGROUND
  Post-transplant lymphoproliferative disease (PTLD) is a serious complication of both solid organ and haematopoietic stem cell transplantation in children. Its incidence has increased over the last decade as a result of more potent immunosuppressive regimens. Many treatments have been explored however optimal therapy remains controversial.
  
  
  OBJECTIVE
  We report on the diagnosis, treatment and outcome of ten patients who were diagnosed with PTLD in Our Lady's Hospital for Sick Children in Dublin between 2004 and 2015 inclusive.
  
  
  METHODS
  Data were collected by retrospective review of patient medical records.
  
  
  RESULTS
  9 out of ten of our patients are alive and disease free following treatment for PTLD with rituximab alone or in combination with chemotherapy.
  
  
  CONCLUSIONS
  The outcome of paediatric patients treated for PTLD at our institution is at least comparable to published international series and supports the use of rituximab ± low dose chemotherapy in the treatment of this malignancy.
authors.affiliation: Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland. andreammalone@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Malone
authors.affiliation: University College Dublin, Dublin, Ireland.|Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland.
authors.forename: G
authors.initials: G
authors.lastname: Kennedy
authors.affiliation: Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland.
authors.forename: L
authors.initials: L
authors.lastname: Storey
authors.affiliation: Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland.|Trinity College Dublin, Dublin, Ireland.
authors.forename: A
authors.initials: A
authors.lastname: O'Marcaigh
authors.affiliation: Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: McDermott
authors.affiliation: Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland.
authors.forename: A M
authors.initials: AM
authors.lastname: Broderick
authors.affiliation: University College Dublin, Dublin, Ireland.|Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland.|Trinity College Dublin, Dublin, Ireland.
authors.forename: O P
authors.initials: OP
authors.lastname: Smith
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015994:Incidence; D007223:Infant; D008232:Lymphoproliferative Disorders / Q000453:epidemiology*; D008297:Male; D016377:Organ Transplantation; D012189:Retrospective Studies; D000069283:Rituximab / Q000008:administration & dosage
chemical_list: D007166:Immunosuppressive Agents; D000069283:Rituximab
keywords: Ebstein-Barr virus; Haematopoietic stem cell transplantation; Immunosuppression; Liver transplant; Paediatric; Post-transplant lymphoproliferative disorder