title: Correlation between Bethatrophin and 25(OH)D Concentrations in a Group of Subjects With Normal and Impaired Glucose Metabolism.
abstract: Aim:Inducing beta cell replication is a potential therapeutic approach for the treatment of diabetes mellitus. Recently betatrophin was suggested as a novel stimulator of beta cell proliferation in mice but its role in humans remains to be established. We aimed to investigate betatrophin concentration and its association with metabolic parameters in a group of individuals with normal glucose tolerance, pre-diabetes and diabetes mellitus who had not been previously treated.Methods:A total of 72 subjects were recruited for this cross sectional study: 23 subjects with normal glucose tolerance (NGT), 22 subjects with prediabetes, and 27 subjects with diabetes mellitus (DM). Circulating betatrophin concentration, 75 g oral glucose tolerance test, fasting insulin, glycosylated hemoglobin, 25hydroxy vitamin D and HOMA IR were measured.Results:The difference in betatrophin values did not reach statistical significance between the 3 groups [NGT:206 (176-297)pg/mL, Prediabetes:232 (181-254)pg/mL, DM:245 (205-526)pg/mL, p=0.078]. Betatrophin was negatively significantly correlated with BMI and positively significantly correlated with 25(OH)vitD (p=0.043 and p=0.001 respectively). Multivariate linear regression showed that 25(OH) vitD (β=0.440 p=0.001) and fasting glucose (β=0.003 p=0.038) were variables associated with betatrophin concentration (R2=0.251).Conclusions:In a group of subjects ranging from those with normal glucose tolerance to newly diagnosed diabetes, we found that 25(OH)D and fasting glucose were factors associated with serum betatrophin concentration.
authors.affiliation: Department of Medical Biochemistry, Çanakkale Onsekiz Mart University, Faculty of Medicine, Çanakkale, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Turkon
authors.affiliation: Department of Clinical Biochemistry, Tepecik Teaching and Research Hospital, Izmir, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Yalcın
authors.affiliation: Department of Clinical Biochemistry, Silopi State Hospital, Sırnak, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Toprak
authors.affiliation: Department of Endocrinology, Tepecik Teaching and Research Hospital Izmir, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Demirpençe
authors.affiliation: Department of Endocrinology, Tepecik Teaching and Research Hospital Izmir, Turkey.
authors.forename: H Y
authors.initials: HY
authors.lastname: Yaşar
authors.affiliation: Department of Clinical Biochemistry, Tepecik Teaching and Research Hospital, Izmir, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Colak
mesh_terms: D000328:Adult; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D001786:Blood Glucose / Q000378:metabolism; D005215:Fasting / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D036361:Peptide Hormones / Q000097:blood*; D011236:Prediabetic State / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D001786:Blood Glucose; D036361:Peptide Hormones; D014807:Vitamin D; C104450:25-hydroxyvitamin D