title: Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families.
abstract: Centenarians are a good healthy aging model. Interestingly, centenarians' offspring are prone to achieve longevity. Here we recruited 60 longevity families and investigated the blood biochemical indexes of family members to seek candidate factors associated with familial longevity. First, associations of blood indexes with age were tested. Second, associations of blood parameters in centenarians (CEN) with their first generation of offspring (F1) and F1 spouses (F1SP) were analyzed. Third, genes involved in regulating target factors were investigated. We found that total cholesterol (TC) and triglyceride (TG) increased with age (20-80 years), but decreased in CEN. Similarly, blood urea nitrogen (BUN) and blood creatinine (BCr) increased with age (20-80 years), but were maintained on a plateau in CEN. Importantly, we first revealed dual changes in blood pressure, i.e., decreased diastolic blood pressure but increased systolic blood pressure in CEN, which associated with altered CST3 expression. Genetic analysis revealed a significant association of blood uric acid (BUA) and BCr in CEN with F1 but not with F1SP, suggesting they may be heritable traits. Taken together, our results suggest serum lipids, kidney function and especially diastolic pressure rather than systolic pressure were improved in CEN or their offspring, suggesting these factors may play an important role in familial longevity.
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.|KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China.
authors.forename: Yong-Han
authors.initials: YH
authors.lastname: He
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.|KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China.
authors.forename: Shao-Yan
authors.initials: SY
authors.lastname: Pu
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.|KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Fu-Hui
authors.initials: FH
authors.lastname: Xiao
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.|KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China.
authors.forename: Xiao-Qiong
authors.initials: XQ
authors.lastname: Chen
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou 571199, China.
authors.forename: Dong-Jing
authors.initials: DJ
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.|KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Yao-Wen
authors.initials: YW
authors.lastname: Liu
authors.affiliation: Department of Biology, Hainan Medical College, Haikou 571199, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Lin
authors.affiliation: Department of Neurology, the Affiliated Hospital of Hainan Medical College, Haikou 571199, China.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Liao
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.|KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.|KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China.
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.|KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Xing-Li
authors.initials: XL
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.|KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Ming-Xia
authors.initials: MX
authors.lastname: Ge
authors.affiliation: Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.|KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Jiang
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou 571199, China.
authors.forename: Wang-Wei
authors.initials: WW
authors.lastname: Cai
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.|KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China.
authors.forename: Qing-Peng
authors.initials: QP
authors.lastname: Kong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D044466:Asian People; D001794:Blood Pressure / Q000502:physiology*; D001806:Blood Urea Nitrogen; D002681:China; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007677:Kidney Function Tests; D050356:Lipid Metabolism / Q000235:genetics; D008055:Lipids / Q000097:blood*; D008136:Longevity; D008297:Male; D008875:Middle Aged; D059467:Transcriptome; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: C525030:CST3 protein, human; D055316:Cystatin C; D008055:Lipids; D014280:Triglycerides; D014527:Uric Acid; D002784:Cholesterol; D003404:Creatinine