title: Anti-Halitosis Effect of Toothpaste Supplemented with Alkaline Extract of the Leaves of Sasa senanensis Rehder.
abstract: BACKGROUND
  Previous studies have shown activity against viruses, bacteria, inflammation and oral lichenoid dysplasia of alkaline extract of the leaves of Sasa senanensis Rehder (SE), suggesting its possible application to oral diseases. In the present study, we performed a small-scale clinical test to investigate whether SE is effective against halitosis and in oral bacterial reduction.
  
  
  METHODS
  A total of 12 volunteers participated in this study. They brushed their teeth immediately after meals three times each day with SE-containing toothpaste (SETP) or placebo toothpaste. Halitosis in the breath and bacterial number on the tongue were measured by commercially available portable apparatuses at a specified time in the morning.
  
  
  RESULTS
  Some relationship was observed between halitosis and bacterial number from each individual, especially when those with severe halitosis were included. Repeated experiments demonstrated that SETP significantly reduced halitosis but not the bacterial number on the tongue.
  
  
  CONCLUSIONS
  The present study provides for the first time the basis for anti-halitosis activity of SE.
authors.affiliation: Meikai University School of Dentistry, Saitama, Japan sakagami@dent.meikai.ac.jp takaakio@daiwaseibutsu.co.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakagami
authors.affiliation: Meikai University School of Dentistry, Saitama, Japan.
authors.forename: Hong
authors.initials: H
authors.lastname: Sheng
authors.affiliation: Meikai University School of Dentistry, Saitama, Japan.
authors.forename: Koki
authors.initials: K
authors.lastname: Ono
authors.affiliation: Meikai University School of Dentistry, Saitama, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Komine
authors.affiliation: Meikai University School of Dentistry, Saitama, Japan.
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Miyadai
authors.affiliation: Meikai University School of Dentistry, Saitama, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Terada
authors.affiliation: Meikai University School of Dentistry, Saitama, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakada
authors.affiliation: Meikai University School of Dentistry, Saitama, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Meikai University School of Dentistry, Saitama, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Matsumoto
authors.affiliation: Meikai University School of Dentistry, Saitama, Japan.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yasui
authors.affiliation: Sampo Pharmaceutical Co., Ltd., Tokyo, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Daiwa Biological Research Institute Co., Ltd., Kanagawa, Japan.
authors.forename: Jia
authors.initials: J
authors.lastname: Junye
authors.affiliation: Daiwa Biological Research Institute Co., Ltd., Kanagawa, Japan.
authors.forename: Takenori
authors.initials: T
authors.lastname: Natori
authors.affiliation: Daiwa Biological Research Institute Co., Ltd., Kanagawa, Japan.
authors.forename: Madoka
authors.initials: M
authors.lastname: Suguro-Kitajima
authors.affiliation: Daiwa Biological Research Institute Co., Ltd., Kanagawa, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Oizumi
authors.affiliation: Daiwa Biological Research Institute Co., Ltd., Kanagawa, Japan sakagami@dent.meikai.ac.jp takaakio@daiwaseibutsu.co.jp.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Oizumi
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology; D058491:Bacterial Load / Q000187:drug effects; D005260:Female; D006209:Halitosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D031787:Sasa / Q000737:chemistry*; D014059:Tongue / Q000187:drug effects / Q000382:microbiology; D014100:Toothpastes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D014100:Toothpastes
keywords: Sasa senanensis Rehder leaf; alkaline extract; antibacterial activity; halitosis; small-scale clinical test; toothpaste