title: Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment.
abstract: Adaptive physiological stress regulation is rarely studied in mild cognitive impairment (MCI). Here we targeted mental fatigability (MF) as a determinant of altered high frequency heart rate variability (HF-HRV) reactivity in individuals with MCI, and examined frontobasal ganglia circuitry as a neural basis supporting the link between MF and HF-HRV reactivity.
  
  
  
  We measured mental fatigability and HF-HRV during a 60-minute cognitive stress protocol in 19 individuals with MCI. HF-HRV responses were modeled using a quadratic equation. Resting state functional connectivity of intra- and inter-network frontobasal ganglia circuitry was assessed using blood-oxygen-level-dependent magnetic resonance imaging among seven of the participants.
  
  
  
  Lower MF was associated with faster and greater rebound in U-shape HF-HRV reactivity, which linked to a stronger connectivity between right middle frontal gyrus and left putamen.
  
  
  
  Results suggest that MF may contribute to abnormal physiological stress regulation in MCI, and fronto basal ganglia circuitry may support the link.
authors.affiliation: School of Nursing, University of Rochester Medical Center, Rochester, NY; Department of Psychiatry, University of Rochester Medical Center, Rochester, NY. Electronic address: Vankee_lin@urmc.rochester.edu.
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.affiliation: School of Nursing, University of Rochester Medical Center, Rochester, NY; Department of Brain and Cognitive Science, University of Rochester, Rochester, NY.
authors.forename: Ping
authors.initials: P
authors.lastname: Ren
authors.affiliation: Department of Brain and Cognitive Science, University of Rochester, Rochester, NY.
authors.forename: Kelly
authors.initials: K
authors.lastname: Cotton
authors.affiliation: Department of Psychiatry, University of Rochester Medical Center, Rochester, NY.
authors.forename: Anton
authors.initials: A
authors.lastname: Porsteinsson
authors.affiliation: Department of Neurology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY.
authors.forename: Mark
authors.initials: M
authors.lastname: Mapstone
authors.affiliation: Department of Psychiatry, University of Rochester Medical Center, Rochester, NY.
authors.forename: Kathi L
authors.initials: KL
authors.lastname: Heffner
mesh_terms: D000368:Aged; D060825:Cognitive Dysfunction / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D005222:Mental Fatigue / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D009434:Neural Pathways / Q000503:physiopathology; D059906:Neuroimaging; D017397:Prefrontal Cortex / Q000503:physiopathology; D011699:Putamen / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications / Q000523:psychology*
keywords: cardiovascular reactivity; frontobasal ganglia circuitry; mental fatigability; mild cognitive impairment; physiological stress regulation