title: Brief Report: HIV Infection Is Associated With Worse Bone Material Properties, Independently of Bone Mineral Density.
abstract: Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.
authors.affiliation: *Infectious Diseases Department, Hospital del Mar, Hospital del Mar Research Institute (IMIM), Barcelona, Spain; †Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain; ‡Internal Medicine Department, Hospital del Mar, Hospital del Mar Research Institute, Barcelona, Spain; §Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom; and ‖Primary Care, ABS Passeig de Sant Joan, Barcelona, Catalan Institute of Health (ICS), Spain.
authors.forename: Robert
authors.initials: R
authors.lastname: Güerri-Fernández
authors.forename: Daniel
authors.initials: D
authors.lastname: Molina
authors.forename: Judit
authors.initials: J
authors.lastname: Villar-García
authors.forename: Daniel
authors.initials: D
authors.lastname: Prieto-Alhambra
authors.forename: Leonardo
authors.initials: L
authors.lastname: Mellibovsky
authors.forename: Xavier
authors.initials: X
authors.lastname: Nogués
authors.forename: Alicia
authors.initials: A
authors.lastname: González-Mena
authors.forename: Ana
authors.initials: A
authors.lastname: Guelar
authors.forename: Marta
authors.initials: M
authors.lastname: Trenchs-Rodríguez
authors.forename: Sabina
authors.initials: S
authors.lastname: Herrera-Fernández
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Horcajada
authors.forename: Adolfo
authors.initials: A
authors.lastname: Díez-Pérez
authors.forename: Hernando
authors.initials: H
authors.lastname: Knobel
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000009:adverse effects; D015519:Bone Density; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck / Q000473:pathology* / Q000821:virology; D015658:HIV Infections / Q000150:complications* / Q000473:pathology / Q000821:virology; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000473:pathology* / Q000821:virology; D018570:Risk Assessment; D013030:Spain
chemical_list: D019380:Anti-HIV Agents