title: Analysis of Serum Endothelial Cell-Specific Molecule 1 (Endocan) Level in Type 2 Diabetes Mellitus With Acute ST-Segment Elevation Myocardial Infarction and its Correlation: A Pilot Study.
abstract: Endothelial cell-specific molecule 1 (ESM-1; endocan) is expressed by endothelial cells, and it can be overexpressed in diabetic patients. However, little is known concerning diabetic patients with acute ST-segment elevation myocardial infarction (STEMI). Therefore, we assessed serum ESM-1 level in patients having type 2 diabetes mellitus (T2DM) STEMI; 72 patients with DM (38 with and 34 without vascular disease) and 33 individuals as a control group were included. There was a significant difference in serum ESM-1 level between the T2DM group and the control group (P = .03). There was also a significant difference in serum ESM-1 level between the T2DM with STEMI group and newly diagnosed T2DM group without vascular disease (P = .01). In patients with T2DM, serum ESM-1 levels correlated positively with high-sensitivity C-reactive protein levels and the neutrophil to lymphocyte ratio (r = .321, P = .006 and r = .320, P = .006). Our findings suggest that serum ESM-1 level may be a novel endothelial dysfunction biomarker and it may be related to vascular disease in T2DM.
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of China.
authors.forename: Chong-Rong
authors.initials: CR
authors.lastname: Qiu
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of China fuqiang@medmail.com.cn.|Xuzhou Institute of Cardiovascular Disease, Xuzhou City, Jiangsu Province, People Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.affiliation: Medical College of Jiangsu University, Zhenjiang, People Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Sui
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wei
authors.affiliation: Medical College of Jiangsu University, Zhenjiang, People Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Medical College of Jiangsu University, Zhenjiang, People Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wan
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D042783:Endothelial Cells / Q000378:metabolism; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D010865:Pilot Projects; D011509:Proteoglycans / Q000097:blood*; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans
keywords: acute ST-segment elevation myocardial infarction; biomarker; diabetes complications; endocan; endothelial cell-specific molecule 1; type 2 diabetes mellitus