title: Development of immune-diagnostic reagents to diagnose bovine tuberculosis in cattle.
abstract: Bovine tuberculosis remains a major economic and animal welfare concern worldwide. As part of control strategies, cattle vaccination is being considered. This approach, used alongside conventional control policies, also requires the development of vaccine compatible diagnostic assays to distinguish infected from vaccinated animals (DIVA). In this review we discuss recent advances in DIVA development based on the detection of host cellular immune responses by blood testing or skin testing approaches.
authors.affiliation: Animal and Plant Health Agency-Weybridge, Addlestone, Surrey, United Kingdom. Electronic address: martin.vordermeier@apha.gsi.gov.uk.
authors.forename: H Martin
authors.initials: HM
authors.lastname: Vordermeier
authors.affiliation: Animal and Plant Health Agency-Weybridge, Addlestone, Surrey, United Kingdom.
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Jones
authors.affiliation: AgResearch, Hopkirk Research Institute, Palmerston North, New Zealand.
authors.forename: Bryce M
authors.initials: BM
authors.lastname: Buddle
authors.affiliation: Animal and Plant Health Agency-Weybridge, Addlestone, Surrey, United Kingdom.
authors.forename: R Glyn
authors.initials: RG
authors.lastname: Hewinson
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000276:immunology; D002417:Cattle; D003937:Diagnosis, Differential; D012882:Skin Tests; D059467:Transcriptome; D014380:Tuberculosis, Bovine / Q000175:diagnosis* / Q000276:immunology; D014611:Vaccination
chemical_list: D001500:BCG Vaccine
keywords: BCG; Cattle; Differential diagnosis; Tuberculosis; Vaccination