title: Evaluation of aspirin hypersensitivity in patients with chronic rhinosinusitis.
abstract: Conclusion The recurrence rates of chronic rhinosinusitis (CRS) were higher in the aspirin nasal provocation test (ANPT)-positive group, regardless of the presence of nasal polyps. Thus, a careful endoscopic examination is required during follow-up in ANPT-positive patients with CRS. Objectives The aim of this study was to evaluate the clinical features and prognosis after surgical treatment in patients with CRS and aspirin hypersensitivity. Methods In a prospective study, 100 patients were analyzed with CRS who underwent endoscopic sinus surgery at the hospital from October 2012 to March 2013. This study measured changes in nasal volume and symptoms before and after the ANPT and examined patient's asthma history, allergy, Lund-Mackay score (LMS), total immunoglobulin E, percentage of peripheral eosinophils, and objectively measured relapse at 6 months. Results Patients wwith CRS and nasal polyps (CRSwNP) were more likely to have a positive ANPT test result compared to those without nasal polyps (CRSsNP) (21.4% vs 5.5%). The ANPT-positive group had a higher LMS and required more revision endoscopic sinus surgery than those in the ANPT-negative group. The results were that similar results were observed in CRSwNP and CRSsNP.
authors.affiliation: a Department of Otorhinolaryngology - Head & Neck Surgery , Graduate School, Kyung Hee University , Seoul , Korea.
authors.forename: Chul
authors.initials: C
authors.lastname: Kwun
authors.affiliation: a Department of Otorhinolaryngology - Head & Neck Surgery , Graduate School, Kyung Hee University , Seoul , Korea.
authors.forename: Su Il
authors.initials: SI
authors.lastname: Kim
authors.affiliation: a Department of Otorhinolaryngology - Head & Neck Surgery , Graduate School, Kyung Hee University , Seoul , Korea.
authors.forename: Kun Hee
authors.initials: KH
authors.lastname: Lee
authors.affiliation: a Department of Otorhinolaryngology - Head & Neck Surgery , Graduate School, Kyung Hee University , Seoul , Korea.
authors.forename: Sung Wan
authors.initials: SW
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D055963:Asthma, Aspirin-Induced / Q000150:complications / Q000175:diagnosis*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009299:Nasal Provocation Tests; D009668:Nose Diseases / Q000150:complications* / Q000601:surgery; D011446:Prospective Studies; D055815:Young Adult
keywords: Aspirin nasal provocation test; chronic rhinosinusitis