title: Investigation of Molecular Mechanism of JC virus Viroporin Activity.
abstract: Viroporins are small and hydrophobic viral proteins that form pores on host cell membranes, and their expression can increase the permeability of cellular membranes and the production of progeny virus particles. JC virus (JCV) is the causative agent of progressive multifocal leukoenchephalopathy (PML). We demonstrate that JCV Agno, which is the small and hydrophobic protein, andincreases the plasma membrane permeability and virion release, acts as a viroporin. We also demonstrate that an interaction of Agno with a host cellular protein regulates the viroporin activity of Agno. These findings indicate a new paradigm in virus-host interactions regulating viroporin activity and viral replication.
authors.affiliation: Department of Pathology, National Institute of Infectious Diseases.
authors.forename: Tadaki
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D002463:Cell Membrane Permeability; D054884:Host-Pathogen Interactions / Q000502:physiology; D006801:Humans; D007577:JC Virus / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology; D007968:Leukoencephalopathy, Progressive Multifocal / Q000821:virology; D008563:Membrane Lipids / Q000378:metabolism; D054334:Viral Regulatory and Accessory Proteins / Q000737:chemistry / Q000502:physiology*; D014771:Virion / Q000378:metabolism; D014779:Virus Replication; D000086082:Viroporin Proteins
chemical_list: D008563:Membrane Lipids; D054334:Viral Regulatory and Accessory Proteins; C042559:agnoprotein, polyomavirus; D000086082:Viroporin Proteins