title: Micellar Catalysis: Bioinspired Micellar Copper Protoporphyrin as a High Performing Nano-Catalyst.
abstract: Herein we have engineered a micellar Cu protoporphyrin catalyst that mediates carbon bond activation using peroxide as an electron source. Cu protoporphyrin is a biomimetic model of active site of chloroperoxidase enzyme, which catalyzes the carbon bond halogenation in the presence of a suitable amount of H2O2. The encapsulation of Cu(II) Protoporphyrin IX/L-Cysteine inside of cetyltrimethylammonium bromide micelle increases the rate of chlorination at pH 3. The cited catalyst resists high concentrations of hydrogen peroxide, which is previously reported as a suicide inactivator component of hemo-enzymes. Isothermal Titration Calorimetry (ITC) and Dynamic Light Scattering (DLS) data have revealed the formation of a micellar complex by encapsulation of six Cu(II) proporphyrins within each micelle. Moreover, electrochemical investigations indicate that L-Cysteine increases the intensity of electron transferred due to the formation of self-assembled monolayer on Au electrode. Our results paved a road toward the design of a more robust mimetic catalysis based on Protoporphyrin IX derivatives.
authors.affiliation: a Institute of Biochemistry and Biophysics, University of Tehran , Tehran , Iran.
authors.forename: Mohammad M
authors.initials: MM
authors.lastname: Akbarzadeh
authors.affiliation: a Institute of Biochemistry and Biophysics, University of Tehran , Tehran , Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Kzemin Jasemi
authors.affiliation: a Institute of Biochemistry and Biophysics, University of Tehran , Tehran , Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Hedayati Katuli
authors.affiliation: b Medical Laboratory of Science , Islamic Azad University of Babol , Babol , Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Dorostgu
authors.affiliation: c Faculty of Bioscience and Medical Engineering , University Technology Malaysia (UTM) , Johor Bahru , Malaysia.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Yazdani
authors.affiliation: d Department of biology , Islamic Azad University of Gorgan , Gorgan , Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Dorostgu
authors.affiliation: a Institute of Biochemistry and Biophysics, University of Tehran , Tehran , Iran.
authors.forename: Behnam
authors.initials: B
authors.lastname: Rad
authors.affiliation: e University of Trento , Department of Civil, Environmental and Mechanical Engineering , via Mesiano, 77, 38123 Trento , Italy.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Sartipnia
authors.affiliation: f Department of nanotechnology, Faculty of Advance Science and Technology, PharmaceuticalSciences Branch , Islamic Azad University (IAUPS) , Tehran , Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Falahati
keywords: Artificial catalyst; Chloroperoxidase; Cu(II) porphyrin IX; Metalloenzyme; Oxidative chlorination