title: Characterization of the down-regulated genes identified in preeclampsia placenta.
abstract: OBJECTIVE
  We focus our attention on placental genes that are repressed in preeclampsia.
  
  
  METHODS
  A search was conducted through the online PubMed database.
  
  
  RESULTS
  A majority of the down-regulated genes appear to be evolved as the defense and protective mechanism for the mother, namely maternal fitness genes. A half of the down-regulated genes are also located within and in close proximity to known imprinted genes.
  
  
  CONCLUSIONS
  Preeclampsia may be associated with either: (1) down-regulated expression of genes located in close proximity to known imprinted genes, (2) an imbalance in the maternal-fetal genetic response, or (3) an interaction of the two.
authors.affiliation: a Department of Obstetrics and Gynecology , Nara Medical University , Nara , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D015536:Down-Regulation; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy
keywords: Genetic conflict; imprinting; maternal; paternal; preeclampsia