title: [Recent Advances on the Immunoregulation of MicroRNA-155 in Mesenchymal Stem Cells--Review].
abstract: Mesenchymal stem cells (MSC) are capable of immunosuppression and differentiating into multiple cell lineages. MSC, which are accessed easily and less side-effects, have been a source of seed cells in tissue-engineering and cell-therapy. However, the application of MSC are limited by their differentiation of instability and easy aging. MicroRNA-155 (miR-155) is one of microRNA, which has powerful regulatory potential in a wide variety of immune cells through degrading specific mRNA after transcription and inhibiting translation of the target genes. Following the research of miR-155 deeply, it has an indispensable role in the proliferation, differentiation and immunoregulation of MSC. This review discusses the current understandings for the role of miR-155 in MSC.
authors.affiliation: Department of Hematology, Center for Hematologic Diseases of Chinese PLA, Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.|Department of Hematology, Second Hospital of Lanzhou University, Lanzhou 730050, Gansu Province, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Hematology, Center for Hematologic Diseases of Chinese PLA, Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.|Department of Hematology, Second Hospital of Lanzhou University, Lanzhou 730050, Gansu Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hematology, Center for Hematologic Diseases of Chinese PLA, Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Hematology, Center for Hematologic Diseases of Chinese PLA, Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China. E-mail: baihai98@tom.com.
authors.forename: Hai
authors.initials: H
authors.lastname: Bai
mesh_terms: D002454:Cell Differentiation; D019070:Cell Lineage; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs