title: Reduced iron parameters and cognitive processes in children and adolescents with DM1 compared to those with standard parameters.
abstract: Anemia in patients with diabetes is not scarce and may contribute to the complications of the disease. The risk of iron deficiency parameters in child sufferers of diabetes type 1, observed in studies, can lead to cognitive impairment. The aim of the study was to determine whether children and adolescents with diabetes type 1, in whom reduced ferric parameters are observed in control tests, may also show reduced cognitive performance. The study included 100 children with diabetes type 1 at the age of 6-17 years. During control tests, patients' morphological blood parameters were measured: red blood cells (RBC), hemoglobin, glycosylated hemoglobin, hematocrit, RBC volume, the molar mass of hemoglobin in RBC (MCH), mean corpuscular hemoglobin in RBC and iron concentrations in serum using flame atomic absorption spectroscopy and the Wechsler Intelligence Scale for Children (WISC-R). Results in the group of children with a diabetes type 1 significantly lower concentration of three ferric parameters affect the non-verbal intelligence measured with WISC-R. The prevalence of reduced ferric parameters justifies further screening in all children with diabetes type 1 and taking up appropriate preventive measures to reduce the risk of their occurrence.
authors.affiliation: Department of Clinical Psychology, Poznan University of Medical Sciences, Poznań, wielkopolskie, Poland.
authors.forename: Ewa
authors.identifier: http://orcid.org/0000-0002-4651-9444
authors.initials: E
authors.lastname: Mojs
authors.affiliation: Department of Clinical Psychology, Poznan University of Medical Sciences, Poznań, wielkopolskie, Poland.
authors.forename: Maia
authors.initials: M
authors.lastname: Stanisławska-Kubiak
authors.affiliation: Department of Clinical Psychology, Poznan University of Medical Sciences, Poznań, wielkopolskie, Poland.
authors.forename: Rafał W
authors.initials: RW
authors.lastname: Wójciak
authors.affiliation: Department of Psychology, Adam Mickiewicz University, Poznan, wielkopolskie, Poland.
authors.forename: Julita
authors.identifier: http://orcid.org/0000-0003-1678-3954
authors.initials: J
authors.lastname: Wojciechowska
authors.affiliation: Department of Paediatric Diabetes and Obesity, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Sabina
authors.initials: S
authors.lastname: Przewoźniak
mesh_terms: D000293:Adolescent; D002648:Child; D003071:Cognition; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D012015:Reference Standards
chemical_list: D007501:Iron
keywords: Chronic Disease; Diabetes Mellitus; Intellectual Property; Iron Metabolism Disorders