title: Enhanced topical delivery of tacrolimus by a carbomer hydrogel formulation with transcutol P.
abstract: Tacrolimus (TAC), a non-steroidal anti-inflammatory and immunosuppressive agent, is used for the treatment of atopic dermatitis (AD) and skin immune diseases. TAC-loaded topical hydrogel formulations composed of carbomer, carnosine, transcutol P (diethylene glycol monoethyl ether) and humectant were prepared. For comparison, TAC-loaded topical cream-type formulations were also prepared and commercially available TAC ointment was used as a reference. A drug release study in vitro revealed that the total amount of TAC released from hydrogels over 24 h was approximately 30 times greater than that for the reference formulation. Compared to the reference ointment and creams, carbomer gel formulations showed higher skin permeation and retention of TAC (significantly different at p < 0.05), especially those with more than 10% of transcutol P. Therefore, carbomer gel formulations with sufficient levels of transcutol P are good candidates for skin delivery of TAC and have potential as therapeutic agents for the treatment of AD or immune skin disorders.
authors.affiliation: a College of Pharmacy , Chung-Ang University , Seoul , Republic of Korea.
authors.forename: Sang Gon
authors.initials: SG
authors.lastname: Lee
authors.affiliation: a College of Pharmacy , Chung-Ang University , Seoul , Republic of Korea.
authors.forename: Jong Bu
authors.initials: JB
authors.lastname: Kang
authors.affiliation: a College of Pharmacy , Chung-Ang University , Seoul , Republic of Korea.
authors.forename: Sung Rae
authors.initials: SR
authors.lastname: Kim
authors.affiliation: a College of Pharmacy , Chung-Ang University , Seoul , Republic of Korea.
authors.forename: Chae Jin
authors.initials: CJ
authors.lastname: Kim
authors.affiliation: a College of Pharmacy , Chung-Ang University , Seoul , Republic of Korea.
authors.forename: Dong Woo
authors.initials: DW
authors.lastname: Yeom
authors.affiliation: a College of Pharmacy , Chung-Ang University , Seoul , Republic of Korea.
authors.forename: Ho Yub
authors.initials: HY
authors.lastname: Yoon
authors.affiliation: a College of Pharmacy , Chung-Ang University , Seoul , Republic of Korea.
authors.forename: Seong Shin
authors.initials: SS
authors.lastname: Kwak
authors.affiliation: a College of Pharmacy , Chung-Ang University , Seoul , Republic of Korea.
authors.forename: Young Wook
authors.initials: YW
authors.lastname: Choi
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000287:Administration, Topical; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D065546:Drug Liberation; D005026:Ethylene Glycols / Q000737:chemistry*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage* / Q000737:chemistry; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000737:chemistry; D012869:Skin Absorption; D016559:Tacrolimus / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D005026:Ethylene Glycols; D007166:Immunosuppressive Agents; C479038:carbomer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C010111:carbitol; D016559:Tacrolimus
keywords: Carbomer gel; skin permeation; tacrolimus; topical delivery; transcutol P