title: Metabolic Syndrome and Mild Cognitive Impairment: A Case-Control Study among Elderly in a Shanghai Suburb.
abstract: BACKGROUND
  Metabolic syndrome (MetS) maybe associated with mild cognitive impairment (MCI).
  
  
  OBJECTIVE
  To investigate the relationship between MetS, with its individual or combined components, and MCI among elderly.
  
  
  METHODS
  A case-control study was conducted among the elderly aged 65 years and over in a community located in the southwestern suburb of Shanghai, China. The Chinese version of the Mini-Mental Status Examination (C-MMSE) was used to screen subjects with MCI. Associations of MetS with its individual or combined components and MCI were analyzed using conditional regression analyses with or without adjustment for gender, education, current smoking, current drinking, and physical activities.
  
  
  RESULTS
  There were 379 subjects with MCI and 379 gender- and age-matched healthy controls in the study. Compared with healthy controls in univariate analyses, subjects with MCI were more likely to have less time spent on physical activity, lower C-MMSE score, heavier weight, larger waistline and hipline, higher diastolic blood pressure, higher body mass index, higher abdominal obesity index, higher serum glycated hemoglobin, higher serum triglycerides, higher serum cholesterol, higher serum uric acid, and higher serum alanine aminotransferase. After multivariable adjustment, MetS was significantly associated with an increased risk of MCI (OR = 2.277; 95% CI: 1.086-4.773). Among MetS components, abdominal obesity (OR = 2.101; 95% CI: 1.224-3.608) and hypertension (OR = 2.075; 95% CI: 1.170-3.678) showed a significant association with MCI, respectively; while these two components were combined, the association was stronger (OR = 2.459; 95% CI: 1.360-4.447).
  
  
  CONCLUSIONS
  MetS and its components, particularly abdominal obesity and hypertension, were found to be significantly associated with the risk of MCI.
authors.affiliation: Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University, Shanghai, China.|School of Public Health, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yao
authors.affiliation: Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden.
authors.forename: Guo-Xin
authors.initials: GX
authors.lastname: Jiang
authors.affiliation: Sheshan Town Community Health Service Center in Shanghai, Shanghai, China.
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jin-Mei
authors.initials: JM
authors.lastname: Chen
authors.affiliation: Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University, Shanghai, China.|School of Public Health, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Cheng
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D002947:Cities / Q000453:epidemiology; D003072:Cognition Disorders / Q000150:complications* / Q000453:epidemiology*; D018672:Community Health Planning; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008659:Metabolic Diseases / Q000150:complications* / Q000453:epidemiology*; D012307:Risk Factors
keywords: Abdominal obesity; case-control study; hypertension; metabolic syndrome; mild cognitive impairment