title: Inflammatory Responses to Salmonella Infections Are Serotype-Specific.
abstract: The main purpose of this study was to investigate the profile of inflammatory response in patients with acute salmonellosis caused by two serotypes of Salmonella enterica, S. Enteritidis and S. Typhimurium, as well as in convalescent patients with previous acute disease caused by S. Enteritidis. Patients with acute disease showed significantly elevated levels of IL-1β, IL-17, IL-10, and calprotectin compared to healthy control subjects. In convalescent patients, these markers were also significantly elevated, with the exception of IL-1β. Multivariate statistical analyses with the use of these variables produced models with a good predictive accuracy resulting in excellent separation of the diseased and healthy cohorts studied. Overall, the results suggest that the profile of inflammatory response in this disease is determined, to a significant degree, by the serotype of Salmonella, and the profile of certain cytokines and calprotectin remains abnormal for a number of months following the acute disease stage.
authors.affiliation: Institute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
authors.forename: Zhanna
authors.initials: Z
authors.lastname: Ktsoyan
authors.affiliation: Institute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
authors.forename: Karine
authors.initials: K
authors.lastname: Ghazaryan
authors.affiliation: Institute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
authors.forename: Gayane
authors.initials: G
authors.lastname: Manukyan
authors.affiliation: Institute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
authors.forename: Anush
authors.initials: A
authors.lastname: Martirosyan
authors.affiliation: "Nork" Clinical Hospital of Infectious Diseases, Ministry of Health of Republic of Armenia, Armenakyan 153, 0047 Yerevan, Armenia.
authors.forename: Armine
authors.initials: A
authors.lastname: Mnatsakanyan
authors.affiliation: Institute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
authors.forename: Karine
authors.initials: K
authors.lastname: Arakelova
authors.affiliation: "Nork" Clinical Hospital of Infectious Diseases, Ministry of Health of Republic of Armenia, Armenakyan 153, 0047 Yerevan, Armenia.
authors.forename: Zaruhi
authors.initials: Z
authors.lastname: Gevorgyan
authors.affiliation: Institute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
authors.forename: Anahit
authors.initials: A
authors.lastname: Sedrakyan
authors.affiliation: "Nork" Clinical Hospital of Infectious Diseases, Ministry of Health of Republic of Armenia, Armenakyan 153, 0047 Yerevan, Armenia.
authors.forename: Ara
authors.initials: A
authors.lastname: Asoyan
authors.affiliation: Institute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
authors.forename: Anna
authors.initials: A
authors.lastname: Boyajyan
authors.affiliation: Faculty of Medical Sciences, University of the West Indies, Mona, Kingston 7, Jamaica.
authors.forename: Rustam
authors.initials: R
authors.lastname: Aminov