title: Impact of thyroidectomy on cardiac manifestations of Graves' disease.
abstract: Graves' disease (GD) has multiple adverse effects on the cardiovascular system. We aimed to examine the outcome of thyroidectomy in patients with cardiac manifestations of GD and evaluate their associated postoperative complications.
  
  
  
  Retrospective analysis using a prospectively collected database.
  
  
  
  A retrospective analysis of our prospectively collected thyroid surgery database was performed. Forty patients with hyperthyroidism due to GD were identified, and each was appropriately age matched to a euthyroid patient with multinodular goiter (MNG). All patients underwent total thyroidectomy. Data relating to cardiac comorbidities were collected from preoperative and postoperative clinic notes, hospital admissions, electrocardiograms, echocardiograms, and blood work. Perioperative biochemical, cardiovascular, and postoperative outcomes were analyzed.
  
  
  
  Twenty-four (60%) GD patients and 14 (35.0%) MNG patients had cardiac manifestations (P = .001). Hypertension resolved in 41.7% of GD patients and 7.7% of MNG patients (P = .00002). Two of the three GD patients with congestive heart failure (CHF) had resolution of CHF with significant improvement in ejection fraction, whereas the one MNG patient with CHF saw no change. Additionally, the majority of GD patients saw a resolution of their tachycardia (68.8%) and atrial fibrillation (100%). Four postoperative complications occurred in both the GD and MNG groups (4/40, 10%).
  
  
  
  Surgical treatment of GD in patients with cardiac manifestations offers rapid clinical improvement of hypertension, impaired left ventricular systolic function, and arrhythmias. When performed by a high-volume surgeon, the complication rate is similar to thyroidectomy for other benign disease.
  
  
  
  4. Laryngoscope, 126:1256-1259, 2016.
authors.affiliation: Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Gauthier
authors.affiliation: Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.
authors.forename: Hossam Eldin
authors.initials: HE
authors.lastname: Mohamed
authors.affiliation: Division of Head and Neck Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Salem I
authors.initials: SI
authors.lastname: Noureldine
authors.affiliation: Center for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, Texas.
authors.forename: Timo Z
authors.initials: TZ
authors.lastname: Nazari-Shafti
authors.affiliation: Division of Endocrinology, Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.|Southeast Louisiana Veterans Health Care System, New Orleans, Louisiana, U.S.A.
authors.forename: Tina K
authors.initials: TK
authors.lastname: Thethi
authors.affiliation: Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.
authors.forename: Emad
authors.initials: E
authors.lastname: Kandil
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000601:surgery*; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008297:Male; D012189:Retrospective Studies; D013318:Stroke Volume; D013965:Thyroidectomy; D018487:Ventricular Dysfunction, Left / Q000209:etiology*
keywords: Graves' disease; Thyroid surgery; hyperthyroidism; thyroid storm; thyroidectomy; thyrotoxicosis