title: MR fingerprinting using the quick echo splitting NMR imaging technique.
abstract: The purpose of the study is to develop a quantitative method for the relaxation properties with a reduced radio frequency (RF) power deposition by combining magnetic resonance fingerprinting (MRF) technique with quick echo splitting NMR imaging technique (QUEST).
  
  
  
  A QUEST-based MRF sequence was implemented to acquire high-order echoes by increasing the gaps between RF pulses. Bloch simulations were used to calculate a dictionary containing the range of physically plausible signal evolutions using a range of T1and T2values based on the pulse sequence. MRF-QUEST was evaluated by comparing to the results of spin-echo methods. The specific absorption rate (SAR) of MRF-QUEST was compared with the clinically available methods.
  
  
  
  MRF-QUEST quantifies the relaxation properties with good accuracy at the estimated head SAR of 0.03 W/kg. T1and T2values estimated by MRF-QUEST are in good agreement with the traditional methods.
  
  
  
  The combination of the MRF and the QUEST provides an accurate quantification of T1and T2simultaneously with reduced RF power deposition. The resulting lower SAR may provide a new acquisition strategy for MRF when RF energy deposition is problematic. Magn Reson Med 77:979-988, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
authors.affiliation: Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Yun
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Dept. of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Ma
authors.affiliation: Siemens AG, Healthcare Sector, Magnetic Resonance, Erlangen, Germany.
authors.forename: Renate
authors.initials: R
authors.lastname: Jerecic
authors.affiliation: Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.|Dept. of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Duerk
authors.affiliation: Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Seiberlich
authors.affiliation: Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.|Dept. of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Gulani
authors.affiliation: Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.|Dept. of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Griswold
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology*; D001923:Brain Chemistry; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
keywords: MR fingerprinting; QUEST; quantitative imaging; relaxation time; specific absorption rate