title: Current research in necrotizing enterocolitis.
abstract: Despite decades of research on necrotizing enterocolitis, we still do not fully understand the pathogenesis of the disease, how to prevent or how to treat the disease. However, as a result of recent significant advances in the microbiology, molecular biology, and cell biology of the intestine of premature infants and infants with necrotizing enterocolitis, there is some hope that research into this devastating disease will yield some important translation into improved outcomes.
authors.affiliation: UCL Institute of Child Health and Great Ormond Street Hospital for Children, London, UK. Electronic address: s.eaton@ucl.ac.uk.
authors.forename: Simon
authors.initials: S
authors.lastname: Eaton
authors.affiliation: UCL Institute of Child Health and Great Ormond Street Hospital for Children, London, UK.
authors.forename: Clare M
authors.initials: CM
authors.lastname: Rees
authors.affiliation: Faculty of Medicine, University of Southampton, Southampton, UK.
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Hall
mesh_terms: D020345:Enterocolitis, Necrotizing / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D064307:Microbiota; D051197:Toll-Like Receptor 4 / Q000235:genetics / Q000378:metabolism
chemical_list: D051197:Toll-Like Receptor 4
keywords: TLR4; inflammation; intestinal microbiota; necrotizing enterocolitis; premature infants; surgery