title: Control Cross-sectional Study Evaluating an Antibiotic Prevention Strategy in 30 Pregnancies Under Clean Intermittent Self-catheterization and Review of Literature.
abstract: To assess the efficacy and safety of a weekly oral cycling antibiotic (WOCA) strategy to prevent UTI in women.
  
  
  
  We performed a monocentric, comparative, retrospective, cross-sectional study on pregnant women under clean intermittent self catheterization between January 2008 and December 2014. WOCA consisted the administration of a single-dose antibiotic, alternating antibiotic A and B once every 2 weeks, according to previous urine cultures.
  
  
  
  Twenty-five women carried out 30 pregnancies. Thirteen pregnancies (43.3%) were in the WOCA group (WCG) strategy and 17 were in the non-WOCA group (NWCG) (56.7%). In the 19 (63.3%) pregnancies with urinary tract infection (UTI), 5 (38.4%) were in WCG, 14 (82.3%) were not (P = .023). There were more cystitis in NWCG (76.5% vs 23.1% P = .009) but more colonization in WCG (46.2% vs 5.8% P = .025). UTIs were due to Escherichia coli, Enterobacter cloacae, and Klebsiella pneumoniae. There was a nonsignificant increase in preterm birth in NWCG (35.3% vs 7.7% P = .10), no small for gestational age neonates, and no significant difference for the mode of delivery, birthweight, and neonatal outcome.
  
  
  
  According to our result, WOCA seems safe and effective on symptomatic UTI frequency and could be promoted to help physicians to manage specific risks in pregnancy.
authors.affiliation: Department of Obstetrics and Gynaecology, APHP, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: Adélie
authors.initials: A
authors.lastname: Michau
authors.affiliation: Infectious Disease Department, APHP, Hôpitaux Universitaires Paris Ile de France Ouest, Garches, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Dinh
authors.affiliation: Neuro Urology Unit, APHP, Hôpitaux Universitaires Paris Ile de France Ouest, Garches, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Denys
authors.affiliation: Physical Medicine and Rehabiltation, APHP, Hôpitaux Universitaires Paris Ile de France Ouest, Garches, France.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Levy
authors.affiliation: Urology Department, APHP, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Chartier-Kastler
authors.affiliation: Infectious Disease Department, Hôpital Universitaire Bretonneau, Tours, France.
authors.forename: Louis
authors.initials: L
authors.lastname: Bernard
authors.affiliation: Department of Obstetrics and Gynaecology, APHP, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Dommergues
authors.affiliation: Department of Obstetrics and Gynaecology, APHP, Groupe Hospitalier Pitié-Salpêtrière, Paris, France; Sorbonne Université, CNRS UMR 7222, INSERM U1150, UPMC Univ Paris 06, Paris, France. Electronic address: jacky.nizard@psl.aphp.fr.
authors.forename: Jacky
authors.initials: J
authors.lastname: Nizard
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D057928:Intermittent Urethral Catheterization / Q000009:adverse effects*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology* / Q000517:prevention & control*; D012189:Retrospective Studies; D014552:Urinary Tract Infections / Q000209:etiology* / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents