title: Serum Angiopoietin-2 as a Clinical Marker for Lung Cancer in Patients with Solitary Pulmonary Nodules.
abstract: To evaluate the clinical significance of angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) in lung cancer patients with solitary pulmonary nodule (SPN). The study enrolled 128 patients with malignant SPN, 60 patients with benign SPN, along with 40 healthy volunteers. Serum concentrations of Ang-2 and VEGF were measured by ELISA. Serum Ang-2 and VEGF levels in patients with malignant SPN were significantly higher than those in patients with benign SPN (p<0.01), and those in healthy volunteers (p<0.05). With a cutoff of 1504.8 pg/mL, the sensitivity and specificity of Ang-2 in differentiating between patients with malignant SPN and patients with benign SPN, and between patients with malignant SPN and healthy volunteers was 69.5 and 92.5%, and 80.5 and 97.5%, respectively. Additionally, higher levels of Ang-2 were associated with higher tumor stage (p<0.05). The levels of Ang-2 correlated with the VEGF level (p<0.01). In conclusion, measurement of serum Ang-2 might be a useful diagnostic marker for SPN patients.
authors.affiliation: Endoscopic Center of Nanjing Chest Hospital, Nanjing, Jiangsu, China Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu, China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Xu
authors.affiliation: Endoscopic Center of Nanjing Chest Hospital, Nanjing, Jiangsu, China Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Endoscopic Center of Nanjing Chest Hospital, Nanjing, Jiangsu, China Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu, China.
authors.forename: Yuchao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Nanjing Jiangning Hospital, Nanjing, Jiangsu, China.
authors.forename: Xiuwei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: MOE Key Laboratory, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yan
authors.affiliation: Endoscopic Center of Nanjing Chest Hospital, Nanjing, Jiangsu, China Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu, China lkyu54@126.com.
authors.forename: Like
authors.initials: L
authors.lastname: Yu
mesh_terms: D042702:Angiopoietin-2 / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D003074:Solitary Pulmonary Nodule / Q000097:blood* / Q000150:complications; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D042702:Angiopoietin-2; D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A
keywords: Angiopoietin-2; biomarker; diagnosis; solitary pulmonary nodule