title: Tumor-height regression rate after brachytherapy between choroidal melanoma gene expression profile classes: effect of controlling for tumor height.
abstract: OBJECTIVE
  To evaluate the relationship between choroidal melanoma regression rate and its gene expression profile class after iodine-125 brachytherapy at 3 and 6 months, controlling for baseline tumor height.
  
  
  METHODS
  Patients from October 2012 to January 2015 at a single Ophthalmic Oncology Center who had undergone iodine-125 brachytherapy for the treatment of choroidal melanoma and who had a gene expression profile test result obtained from intraoperative fine-needle aspiration biopsy at the time of plaque surgery were retrospectively reviewed. Baseline patient and tumor characteristics were obtained, including tumor height and gene expression profile test result. Tumor height at 3 and 6 months following treatment was obtained. Regression rate was analyzed with two-way analysis of variance to class type and baseline pre-operative tumor height. Class 2 patients were matched to class 1 patients by tumor height and resulting distributions of paired regression rate differences were compared.
  
  
  RESULTS
  A total of 114 patients were studied. When preoperative tumor height was controlled for in the comparative analysis, neither group of patients at 3 or 6 months had a significant dependency between gene expression profile class and tumor regression rate. Additionally, class 1 and class 2 patients matched for pre-operative tumor height did not express different regression rates.
  
  
  CONCLUSIONS
  Our study adds to a growing body of evidence that tumor regression rate does not necessarily depend on gene expression profile class type in choroidal melanoma after brachytherapy at 3 and 6 months when controlling for baseline tumor height.
authors.affiliation: Stein Eye and Doheny Eye Institutes, Department of Ophthalmology, University of California, Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095, USA.|David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, 12-109, Los Angeles, CA, 90095, USA.
authors.forename: Kishan
authors.initials: K
authors.lastname: Gupta
authors.affiliation: Stein Eye and Doheny Eye Institutes, Department of Ophthalmology, University of California, Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095, USA.
authors.forename: Colin A
authors.initials: CA
authors.lastname: McCannel
authors.affiliation: Department of Radiation Oncology, University of California, Los Angeles, 200 Medical Plaza, Los Angeles, CA, 90095, USA.
authors.forename: Mitchell
authors.initials: M
authors.lastname: Kamrava
authors.affiliation: Department of Radiation Oncology, University of California, Los Angeles, 200 Medical Plaza, Los Angeles, CA, 90095, USA.
authors.forename: James
authors.initials: J
authors.lastname: Lamb
authors.affiliation: Stein Eye and Doheny Eye Institutes, Department of Ophthalmology, University of California, Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095, USA.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Almanzor
authors.affiliation: Stein Eye and Doheny Eye Institutes, Department of Ophthalmology, University of California, Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095, USA. tmccannel@jsei.ucla.edu.|Stein Eye Institute, University of California, Los Angeles, 200 Stein Plaza, Los Angeles, CA, 90095, USA. tmccannel@jsei.ucla.edu.
authors.forename: Tara A
authors.initials: TA
authors.lastname: McCannel
mesh_terms: D000368:Aged; D044963:Biopsy, Fine-Needle; D001918:Brachytherapy / Q000379:methods*; D002830:Choroid Neoplasms / Q000235:genetics / Q000473:pathology* / Q000532:radiotherapy; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm / Q000235:genetics*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000473:pathology* / Q000532:radiotherapy; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D014604:Uveal Neoplasms / Q000235:genetics / Q000473:pathology* / Q000532:radiotherapy; D014792:Visual Acuity; D000098943:Uveal Melanoma
chemical_list: D007457:Iodine Radioisotopes
keywords: Biopsy; Brachytherapy; Choroidal melanoma; Gene expression profile; Molecular prognostic test; Ocular melanoma; Regression; Uveal melanoma