title: Low dose aspirin and pregnancy: how important is aspirin resistance?
abstract: Antiplatelet agents are pivotal for prevention of coronary artery disease and cerebrovascular disease worldwide. Individual patient data meta-analysis indicates that low-dose aspirin causes a 10% risk reduction in pre-eclampsia for women at high individual risk. However, in the last 15 years it has emerged that a significant proportion of aspirin-treated individuals exhibit suboptimal platelet response, determined biochemically and clinically, termed 'aspirin non-responsiveness', 'aspirin resistance' and 'aspirin treatment failure'. More recently, investigation of aspirin responsiveness has begun in pregnant women. This review explores the history and clinical relevance of 'aspirin resistance' applied to high-risk obstetric populations.
  
  
  CONCLUSIONS
  Is 'aspirin resistance' clinically relevant in high-risk obstetrics?
authors.affiliation: Centre for Women's Health Research, Institute of Translation Medicine, University of Liverpool, Liverpool, UK.
authors.forename: K
authors.initials: K
authors.lastname: Navaratnam
authors.affiliation: The Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
authors.forename: A
authors.initials: A
authors.lastname: Alfirevic
authors.affiliation: Centre for Women's Health Research, Institute of Translation Medicine, University of Liverpool, Liverpool, UK.
authors.forename: Z
authors.initials: Z
authors.lastname: Alfirevic
mesh_terms: D001241:Aspirin / Q000627:therapeutic use*; D001760:Bleeding Time; D001792:Blood Platelets; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance / Q000235:genetics / Q000502:physiology*; D005260:Female; D006801:Humans; D055118:Medication Adherence; D000071184:Pharmacogenomic Variants; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010979:Platelet Function Tests; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D017211:Treatment Failure
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin
keywords: Activation; aspirin; platelet; pre-eclampsia; pregnancy; resistance