title: Mild forms of toxic shock syndrome toxin-1-mediated exanthematous disease related to Staphylococcus aureus infection.
abstract: The present report describes three patients with toxic shock syndrome toxin (TSST)-1-associated exanthematous disease. In all patients, fever and systemic erythema without hemodynamic disturbance occurred following cellulitis of the lower limbs. At the site of infection, TSST-1 producing Methicillin-susceptible Staphylococcus aureus was detected. They defervesced and erythema resolved in response to administration of an antimicrobial drug, thereby avoiding severe illness. These patients did not meet the criteria for a clinical diagnosis of toxic shock syndrome. Measurement of T-cell receptor Vβ2-positive T cells in the peripheral blood early after onset of symptoms was useful for diagnosis.
authors.affiliation: Department of Pediatrics, Sakai Hospital Kinki University Faculty of Medicine, Japan. Electronic address: naohiko@sakai.med.kindai.ac.jp.
authors.forename: Naohiko
authors.initials: N
authors.lastname: Moriguchi
authors.affiliation: Department of Pediatrics, Sakai Hospital Kinki University Faculty of Medicine, Japan.
authors.forename: Tomowa
authors.initials: T
authors.lastname: Kano
authors.affiliation: Department of Pediatrics, Sakai Hospital Kinki University Faculty of Medicine, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshimatsu
authors.affiliation: Department of Pediatrics, Sakai Hospital Kinki University Faculty of Medicine, Japan.
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Yanagida
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000633:toxicity*; D002648:Child; D002675:Child, Preschool; D004768:Enterotoxins / Q000633:toxicity*; D005076:Exanthema / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D016106:Methicillin Resistance / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000472:pathogenicity*; D012772:Shock, Septic / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000150:complications* / Q000188:drug therapy; D018089:Superantigens / Q000633:toxicity*
chemical_list: D000890:Anti-Infective Agents; D001427:Bacterial Toxins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal
keywords: Exanthematous disease; Staphylococcus aureus; Superantigen; Toxic shock syndrome toxin-1; Vβ2-positive T cells