title: Mechanisms of Disease of Eosinophilic Esophagitis.
abstract: Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disease of the esophagus with clinical symptoms derived from esophageal dysfunction. The etiology of EoE is now being elucidated, and food hypersensitivity is emerging as the central cornerstone of disease pathogenesis. Herein, we present a thorough picture of the current clinical, pathologic, and molecular understanding of the disease with a focus on disease mechanisms.
authors.affiliation: Division of Immunology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242; email: ben-davis@uiowa.edu.
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Davis
authors.affiliation: Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229; email: rothenberg@cchmc.org.
authors.forename: Marc E
authors.initials: ME
authors.lastname: Rothenberg
mesh_terms: D057765:Eosinophilic Esophagitis / Q000209:etiology / Q000503:physiopathology*; D005512:Food Hypersensitivity / Q000150:complications; D006801:Humans
keywords: atopy; barrier dysfunction; eosinophilic esophagitis; epithelial inflammation; fibrosis