title: Lysosomes in cancer-living on the edge (of the cell).
abstract: The lysosomes have definitely polished their status inside the cell. Being discovered as the last resort of discarded cellular biomass, the steady rising of this versatile signaling organelle is currently ongoing. This review discusses the recent data on the unconventional functions of lysosomes, focusing mainly on the less studied lysosomes residing in the cellular periphery. We emphasize our discussion on the emerging paths the lysosomes have taken in promoting cancer progression to metastatic disease. Finally, we address how the altered cancerous lysosomes in metastatic cancers may be specifically targeted and what are the pending questions awaiting for elucidation.
authors.affiliation: Cell Death and Metabolism Unit, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark.
authors.forename: Saara
authors.initials: S
authors.lastname: Hämälistö
authors.affiliation: Cell Death and Metabolism Unit, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark. Electronic address: mj@cancer.dk.
authors.forename: Marja
authors.initials: M
authors.lastname: Jäättelä
mesh_terms: D002448:Cell Adhesion; D002470:Cell Survival; D005089:Exocytosis; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology