title: Successful salvage treatment of acute graft-versus-host disease after liver transplantation by withdrawal of immunosuppression: a case report.
abstract: Acute graft-versus-host disease (GVHD) following liver transplantation is a rare but fatal complication. The correct diagnosis and management of GVHD after liver transplantation are still major challenges. Herein, we reported successful salvage treatment of acute GVHD by withdrawal of immunosuppression in a patient who presented with fever, skin rashes, and decreased blood cell counts after liver transplantation. This case highlights the need for awareness of drug-induced liver injury if liver function tests are elevated during treatment, especially in patients taking multiple potentially hepatotoxic drugs, such as broad-spectrum antibiotics. When occurs, an artificial liver support system is a useful tool to provide temporary support of liver function for the patient in the event of drug-induced liver injury.
authors.affiliation: Department of Hepato-biliary Pancreatic Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qiu
authors.affiliation: Department of Hepato-biliary Pancreatic Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Guo-Yue
authors.initials: GY
authors.lastname: Lv
authors.affiliation: Department of Hepato-biliary Pancreatic Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Hepato-biliary Pancreatic Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Hepato-biliary Pancreatic Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Sun
authors.affiliation: Department of Hepato-biliary Pancreatic Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Xiao-Ju
authors.initials: XJ
authors.lastname: Shi
authors.affiliation: Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: Xue-Yan
authors.initials: XY
authors.lastname: Liu
authors.affiliation: Department of Hepato-biliary Pancreatic Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Guang-Yi
authors.initials: GY
authors.lastname: Wang
keywords: Drug-induced liver injury; Graft-versus-host disease; Liver transplantation