title: Influence of Endothelin-1 in Aqueous Humor on Intermediate-Term Trabeculectomy Outcomes.
abstract: Purpose. To investigate whether increased concentrations of ET-1 in aqueous humor of glaucoma patients influences surgical outcome of standard trabeculectomy with Mitomycin C. Methods. Retrospective chart review of 36 glaucoma patients with known ET-1 concentrations who had undergone trabeculectomy with Mitomycin C. Patients were divided into two groups based on their aqueous ET-1 concentration, a below-median (low ET-1) and an above-median (high ET-1) group. Postoperative IOP development, necessity of glaucoma medication, surgical success and complications, postoperative use of antifibrotics (5-FU), and number of additional glaucoma surgeries were compared between the groups. Results. Overall surgical success of trabeculectomy was comparable to published literature (90%, 81%, 76%, and 68% absolute success at 12, 24, 36, and 48 months after surgery). There was no difference between high and low ET-1 group in the postsurgical development of IOP, surgical success rate, or complication rate. There was no difference in postoperative scarring or indirect indicators thereof (e.g., number of 5-FU injections, needlings, suture lyses, or IOP lowering medications). Conclusion. In this set of patients, ET-1 in aqueous humor does not appear to have influenced surgical outcome of trabeculectomy with Mitomycin C. There is no indication of an increased likelihood of bleb fibrosis in patients with increased ET-1 concentrations.
authors.affiliation: University Hospital Magdeburg, Department of Ophthalmology, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Choritz
authors.affiliation: University Medical Center Mainz, Department of Ophthalmology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Mahmoodi
authors.affiliation: University Hospital Magdeburg, Department of Ophthalmology, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany.
authors.forename: Hagen
authors.initials: H
authors.lastname: Thieme