title: Results of the treatment of keratocystic odontogenic tumours using enucleation and treatment of the residual bony defect with Carnoy's solution.
abstract: This retrospective study aimed to investigate the recurrence rate of keratocystic odontogenic tumours (KCOTs) treated by enucleation and the application of Carnoy's solution, and to assess the surgical morbidities associated with this treatment. KCOTs treated using a standard protocol of enucleation and the application of Carnoy's solution between 1990 and 2013 were evaluated. One hundred and five KCOTS in 105 patients (54 male, 51 female) were analysed. The mean follow-up period was 86.6 months (range 24-313 months). The recurrence rate was 11.4%. A postoperative inferior alveolar nerve neurosensory deficit occurred in 30.1% of the mandibular cases, with 16% of these being permanent. The postoperative infection and fracture rates were 1.9% and 0.9%, respectively. Younger age, multilocular KCOTs, larger tumour size, and longer antero-posterior lesion length on the radiograph were found to be risk factors for recurrence. It is concluded that enucleation and the application of Carnoy's solution to treat KCOTs results in a relatively low recurrence rate and a low rate of surgical morbidities.
authors.affiliation: Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong. Electronic address: mikeyyleung@hku.hk.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Leung
authors.affiliation: Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
authors.forename: S L
authors.initials: SL
authors.lastname: Lau
authors.affiliation: Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
authors.forename: K Y Y
authors.initials: KY
authors.lastname: Tsoi
authors.affiliation: Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
authors.forename: H L
authors.initials: HL
authors.lastname: Ma
authors.affiliation: Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
authors.forename: C L
authors.initials: CL
authors.lastname: Ng
mesh_terms: D019342:Acetic Acid / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002725:Chloroform / Q000627:therapeutic use*; D000431:Ethanol / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000188:drug therapy / Q000601:surgery; D008441:Maxillary Neoplasms / Q000188:drug therapy / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009808:Odontogenic Tumors / Q000188:drug therapy / Q000601:surgery; D011183:Postoperative Complications; D012189:Retrospective Studies
chemical_list: C033474:Carnoy's solution; D000431:Ethanol; D002725:Chloroform; D019342:Acetic Acid
keywords: Carnoy's solution; enucleation; keratocyst; keratocystic odontogenic tumour; odontogenic