title: The effect of loading dose of magnesium sulfate on uterine, umbilical, and fetal middle cerebral arteries Doppler in women with severe preeclampsia: A case control study.
abstract: SYNOPSIS IV MgSO4 administration in women with severe preeclampsia resulted in a decrease in umbilical artery, uterine artery, and fetal middle cerebral artery Doppler indices.
  
  
  OBJECTIVE
  To evaluate Doppler parameters of the umbilical artery (UmA), uterine artery (UA), and fetal middle cerebral artery (MCA) before and after MgSO4 administration in women with severe preeclampsia.
  
  
  METHODS
  A case control study included 100 pregnant women with severe preeclampsia. Umbilical artery, uterine artery, and fetal middle cerebral artery Doppler were measured before and 20 minutes after intravenous administration of 6 g of magnesium sulfate.
  
  
  RESULTS
  There was a significant difference between maternal systolic blood pressure (173.20 ± 22.72 vs. 156.60 ± 19.18), diastolic blood pressure (109.60 ± 9.14 vs. 101.90 ± 10.05), and heart rate (80.52 ± 11.52 vs. 88.48 ± 12.08) before and after administration of MgSO4 in the studied patients (p value < 0.001). There was a significant difference between umbilical artery, middle cerebral artery, and uterine artery Doppler parameters before and after administration of MgSO4 in the studied patients (p value < 0.001). There was no significant difference between umbilical artery/middle cerebral artery with regard to RI and PI. However, there was significant difference with regard to the S/D ratio (p value < 0.001). The decrease in the values of Doppler parameters before and after administration of MgSO4 was more in the middle cerebral artery than in the umbilical artery.
  
  
  CONCLUSIONS
  Intravenous administration of magnesium sulfate in pregnant women with severe preeclampsia resulted in a decrease in umbilical artery, uterine artery, and fetal middle cerebral artery Doppler indices with reduced resistance to blood flow in these vessels.
authors.affiliation: a Obstetrics and Gynecology Department , Kasr Aini Hospital, Cairo University, Cairo, Egypt and.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Maged
authors.affiliation: a Obstetrics and Gynecology Department , Kasr Aini Hospital, Cairo University, Cairo, Egypt and.
authors.forename: Ahmed M T
authors.initials: AM
authors.lastname: Hashem
authors.affiliation: a Obstetrics and Gynecology Department , Kasr Aini Hospital, Cairo University, Cairo, Egypt and.
authors.forename: Sherine H
authors.initials: SH
authors.lastname: Gad Allah
authors.affiliation: a Obstetrics and Gynecology Department , Kasr Aini Hospital, Cairo University, Cairo, Egypt and.
authors.forename: Mohamed El
authors.initials: ME
authors.lastname: Mahy
authors.affiliation: a Obstetrics and Gynecology Department , Kasr Aini Hospital, Cairo University, Cairo, Egypt and.
authors.forename: Walaa A I
authors.initials: WA
authors.lastname: Mostafa
authors.affiliation: b Obstetrics and Gynecology Department , Beni-Suef University, Beni-Suef, Egypt.
authors.forename: Amal
authors.initials: A
authors.lastname: Kotb
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000494:pharmacology* / Q000627:therapeutic use; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D011225:Pre-Eclampsia / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011247:Pregnancy; D011673:Pulsatile Flow / Q000187:drug effects; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging / Q000187:drug effects*; D055988:Uterine Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D014599:Uterus / Q000098:blood supply; D014655:Vascular Resistance / Q000187:drug effects; D055815:Young Adult
chemical_list: D008278:Magnesium Sulfate
keywords: Doppler ultrasound; hypertension; magnesium sulfate; middle cerebral artery; preeclampsia; umbilical artery; uterine artery