title: HLA-A, -B and -DRB1 allele and haplotype frequencies of 8333 Chinese Han from the Zhejiang province, China.
abstract: The distribution of human leucocyte antigen (HLA) allele and haplotype is varied among different ethnic populations. In this study, HLA-A, -B and -DRB1 allele and haplotype frequencies were determined in 8333 volunteer bone marrow donors of Zhejiang Han population using the polymerase chain reaction sequence-based typing. A total of 52 HLA-A, 96 HLA-B and 61 HLA-DRB1 alleles were found. Of these, the top three frequent alleles in HLA-A, HLA-B and HLA-DRB1 loci, respectively, were A*11:01 (24.53%), A*24:02 (17.35%), A*02:01 (11.58%); B*40:01 (15.67%), B*46:01 (11.87%), B*58:01 (9.05%); DRB1*09:01 (17.54%),DRB1*12:02 (9.64%) and DRB1*08:03 (8.65%). A total of 171 A-B-DRB1 haplotypes with a frequency of >0.1% were presented and the five most common haplotypes were A*33:03-B*58:01- DRB1*03:01, A*02:07-B*46:01-DRB1*09:01, A*30:01-B*13:02-DRB1*07:01, A*33:03-B*58:01-RB1*13:02 and A*11:01-B*15:02-DRB1*12:02. The information will be useful for selecting unrelated bone marrow donors and for anthropology studies and pharmacogenomics analysis.
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, China.|Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: He
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, China.|Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, China.
authors.forename: N
authors.initials: N
authors.lastname: Chen
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, China.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, China.|Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, China.
authors.forename: J
authors.initials: J
authors.lastname: He
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Han
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, China.|Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, China.
authors.forename: S
authors.initials: S
authors.lastname: Tao
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, China.
authors.forename: L
authors.initials: L
authors.lastname: Dong
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, China.|Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, China.
authors.forename: J
authors.initials: J
authors.lastname: He
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, China.|Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, China.
authors.forename: F
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, China.|Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, China.
authors.forename: H
authors.initials: H
authors.lastname: Lv
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D005787:Gene Frequency; D005828:Genetics, Population; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D011159:Population Surveillance; D055815:Young Adult
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059811:HLA-DRB1 Chains