title: Prevalence of celiac disease and related antibodies in patients diagnosed with irritable bowel syndrome according to the Rome III criteria. A case-control study.
abstract: The cost-effectiveness for screening for celiac disease (CD) in patients with irritable bowel syndrome (IBS), specifically in the diarrhea (IBS-D) subtype, is beneficial if the prevalence is >1%. However, recent studies have shown controversial results. In this large case-control study, our aim was to determine the prevalence of CD and a panel of related antibodies in patients diagnosed with IBS.
  
  
  
  Four hundred IBS patients (Rome III) and 400 asymptomatic healthy controls were prospectively evaluated using antihuman tissue transglutaminase (h-tTG IgA) and deamidated gliadin peptide antibodies (DGP II IgA and DGP II IgG). Duodenal biopsy was performed on the patients that were positive for the h-tTG IgA and/or DGP II IgG antibodies.
  
  
  
  The mean age of the population was 44.47 ± 18.01 years and 335 (82%) of the subjects were women. Twenty-one patients and six controls had at least one positive test for CD (5.25% VS 1.5%, p = 0.003, OR 3.63 [95% CI 1.4-9.11]). Eighteen patients were positive for h-tTG and/or DGP-II IgG. Histologic confirmation of CD was 2.5% in the IBS patients vs 0.5% in the controls (p = 0.04, OR 5.21). The IBS-D subtype had the highest prevalence for serological positivity (12.7%).
  
  
  
  Up to 5.2% of the patients with IBS according to the Rome III criteria were positive for at least one of the CD-related antibodies and 2.5% had biopsy-confirmed CD. Therefore, in our population, screening for CD in subjects with IBS appears to be a reasonable strategy, especially in the IBS-D subgroup.
authors.affiliation: Gastrointestinal Motility and Digestive Physiology Laboratory, Medical and Biological Research Institute of the Universidad Veracruzana, Veracruz, Veracruz, Mexico.|Doctorate in Biomedical Sciences, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
authors.forename: L A
authors.initials: LA
authors.lastname: Sánchez-Vargas
authors.affiliation: Gastrointestinal Motility and Digestive Physiology Laboratory, Medical and Biological Research Institute of the Universidad Veracruzana, Veracruz, Veracruz, Mexico.|Doctorate in Biomedical Sciences, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
authors.forename: P
authors.initials: P
authors.lastname: Thomas-Dupont
authors.affiliation: Gastrointestinal Motility and Digestive Physiology Laboratory, Medical and Biological Research Institute of the Universidad Veracruzana, Veracruz, Veracruz, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Torres-Aguilera
authors.affiliation: Gastrointestinal Motility and Digestive Physiology Laboratory, Medical and Biological Research Institute of the Universidad Veracruzana, Veracruz, Veracruz, Mexico.
authors.forename: A A
authors.initials: AA
authors.lastname: Azamar-Jacome
authors.affiliation: Gastrointestinal Motility and Digestive Physiology Laboratory, Medical and Biological Research Institute of the Universidad Veracruzana, Veracruz, Veracruz, Mexico.
authors.forename: K L
authors.initials: KL
authors.lastname: Ramírez-Ceervanes
authors.affiliation: Gastrointestinal Motility and Digestive Physiology Laboratory, Medical and Biological Research Institute of the Universidad Veracruzana, Veracruz, Veracruz, Mexico.
authors.forename: M R
authors.initials: MR
authors.lastname: Aedo-Garcés
authors.affiliation: Gastrointestinal Motility and Digestive Physiology Laboratory, Medical and Biological Research Institute of the Universidad Veracruzana, Veracruz, Veracruz, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Meixueiro-Daza
authors.affiliation: Gastrointestinal Motility and Digestive Physiology Laboratory, Medical and Biological Research Institute of the Universidad Veracruzana, Veracruz, Veracruz, Mexico.|Faculty of Medicine Miguel Alemán Valdés, Veracruz, Veracruz, Mexico.
authors.forename: F
authors.initials: F
authors.lastname: Roesch-Dietlen
authors.affiliation: Gastrointestinal Motility and Digestive Physiology Laboratory, Medical and Biological Research Institute of the Universidad Veracruzana, Veracruz, Veracruz, Mexico.
authors.forename: P
authors.initials: P
authors.lastname: Grube-Pagola
authors.affiliation: Gastrointestinal Motility and Digestive Physiology Laboratory, Medical and Biological Research Institute of the Universidad Veracruzana, Veracruz, Veracruz, Mexico.
authors.forename: H
authors.initials: H
authors.lastname: Vivanco-Cid
authors.affiliation: Gastrointestinal Motility and Digestive Physiology Laboratory, Medical and Biological Research Institute of the Universidad Veracruzana, Veracruz, Veracruz, Mexico.|Faculty of Medicine Miguel Alemán Valdés, Veracruz, Veracruz, Mexico.
authors.forename: J M
authors.initials: JM
authors.lastname: Remes-Troche
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D002446:Celiac Disease / Q000097:blood* / Q000145:classification / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D043183:Irritable Bowel Syndrome / Q000097:blood* / Q000145:classification / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A
keywords: Mexico; celiac disease; diarrhea; gluten; irritable bowel syndrome