title: Antiglycation Activity of Iridoids and Their Food Sources.
abstract: Iridoids are dietary phytochemicals that may have the ability to inhibit the formation of advanced glycation end products (AGEs). Three studies were conducted to investigate this anti-AGE potential. First, the inhibition of fluorescence intensity by food-derived iridoids, after 4 days of incubation with bovine serum albumin, glucose, and fructose, was used to evaluate in vitro antiglycation activity. Next, an 8-week open-label pilot study used the AGE Reader to measure changes in the skin autofluorescence of 34 overweight adults who consumed daily a beverage containing food sources of iridoids. Finally, a cross-sectional population study with 3913 people analyzed the relationship between daily iridoid intake and AGE accumulation, as measured by skin autofluorescence with the TruAge scanner. In the in vitro test, deacetylasperulosidic acid and loganic acid both inhibited glycation in a concentration-dependent manner, with respective IC50 values of 3.55 and 2.69 mM. In the pilot study, average skin autofluorescence measurements decreased by 0.12 units (P < 0.05). The cross-sectional population survey revealed that, for every mg of iridoids consumed, there is a corresponding decline in AGE associated age of 0.017 years (P < 0.0001). These results suggest that consumption of dietary sources of iridoids may be a useful antiaging strategy.
authors.affiliation: Research and Development, Morinda, Inc., 737 East 1180 South, American Fork, UT 84003, USA.
authors.forename: Brett J
authors.initials: BJ
authors.lastname: West
authors.affiliation: Research and Development, Morinda, Inc., 3-2-2 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
authors.forename: Akemi
authors.initials: A
authors.lastname: Uwaya
authors.affiliation: Research and Development, Morinda, Inc., 3-2-2 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Isami
authors.affiliation: Research and Development, Morinda, Inc., 737 East 1180 South, American Fork, UT 84003, USA.
authors.forename: Shixin
authors.initials: S
authors.lastname: Deng
authors.affiliation: Department of Language and Literature, Kyoritsu Women's Junior College, 2-2-1 Hitotsubashi, Chiyoda-ku, Tokyo 101-8437, Japan.
authors.forename: Sanae
authors.initials: S
authors.lastname: Nakajima
authors.affiliation: Research and Development, Morinda, Inc., 737 East 1180 South, American Fork, UT 84003, USA.
authors.forename: C Jarakae
authors.initials: CJ
authors.lastname: Jensen