title: Myostatin as a Marker for Doxorubicin Induced Cardiac Damage.
abstract: OBJECTIVE
  Doxorubicin (DXR) is an effective chemotherapeutic agent but causes severe cardiac failure over known doses. Thus, early detection and prevention of cardiac damage is important. Various markers have been tested for early detection of cardiac damage. Myostatin is a protein produced in skeletal muscle cells inhibits muscle differentiation and growth during myogenesis.
  
  
  METHODS
  We evaluated the role of myostatin as a marker for showing DXR induced cardiac damage and compared with well known cardiac markers like NT-proBNP, hs-TnT and CK in a rat model of chronic DXR cardiotoxicity.
  
  
  RESULTS
  Myostatin, NT-proBNP, and hs-TnT but not CK rose significantly during DXR treatment.
  
  
  CONCLUSIONS
  Myostatin can be used as an early marker of DXR induced cardiotoxicity.
authors.affiliation: Departments of Pediatric Oncology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Vural
authors.initials: V
authors.lastname: Kesik
authors.affiliation: Departments of Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Honca
authors.affiliation: Departments of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gulgun
authors.affiliation: Departments of Physiology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Uysal
authors.affiliation: Departments of Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Yasemin Gulcan
authors.initials: YG
authors.lastname: Kurt
authors.affiliation: Departments of Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Tuncer
authors.initials: T
authors.lastname: Cayci
authors.affiliation: Departments of Pediatric Hematology, Gulhane Military Medical Academy, Ankara, Turkey vural73@yahoo.com.
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Babacan
authors.affiliation: Departments of Public Health, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Gocgeldi
authors.affiliation: Departments of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Nadir
authors.initials: N
authors.lastname: Korkmazer
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004317:Doxorubicin / Q000009:adverse effects*; D006331:Heart Diseases / Q000097:blood* / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology*; D055435:Myostatin / Q000097:blood*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D016877:Oxidants / Q000378:metabolism; D010446:Peptide Fragments / Q000097:blood; D017207:Rats, Sprague-Dawley; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; D055435:Myostatin; D016877:Oxidants; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D004317:Doxorubicin; D003402:Creatine Kinase
keywords: Myostatin; cardiac failure; doxorubicin; rat; toxicity