title: MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42.
abstract: Competitive endogenous messenger RNAs (ceRNAs) affect other RNAs transcription through competitively binding common microRNAs (miRNAs). In this study we identified long non-coding RNA (lncRNA) MALAT1 can function as a ceRNA of cell division cycle 42 (cdc42) 3'UTR in inducing migration and invasion of breast cancer cells via miR-1. We found that miR-1 bound both MALAT1 and cdc42 3'UTR directly. Further study showed that MALAT1 induced migration and invasion of breast cancer cells while reduced the level of cdc42. Our results suggest that MALAT1 regulated migration and invasion of breast cancer cells via affecting cdc42 through binding miR-1 competitively.
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China; Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
authors.forename: Jinjiang
authors.initials: J
authors.lastname: Chou
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China; Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
authors.forename: Bingyu
authors.initials: B
authors.lastname: Wang
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China; Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
authors.forename: Tianjing
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China; Jingsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China.
authors.forename: Xiaoman
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China; Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
authors.forename: Lufeng
authors.initials: L
authors.lastname: Zheng
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China; Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
authors.forename: Jinhang
authors.initials: J
authors.lastname: Hu
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China; Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China; Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Xing
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China; Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing 210009, People's Republic of China. Electronic address: xitao18@hotmail.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Xi
mesh_terms: D020413:3' Untranslated Regions; D001667:Binding, Competitive; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000503:physiopathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics / Q000502:physiology; D015536:Down-Regulation; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation; D020764:cdc42 GTP-Binding Protein / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; C557041:MALAT1 long non-coding RNA, human; C544547:MIRN1 microRNA, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D020764:cdc42 GTP-Binding Protein
keywords: Invasion; MALAT1; Migration; cdc42; ceRNA; miR-1