title: Analysis of motor unit firing characteristics in patients with motor neuron diseases.
abstract: This study was designed to evaluate firing rate variability in patients with upper/lower motor neuron disorders. Twenty healthy subjects and 19 patients with motor neuron disorders participated in the study. Consecutive motor unit action potential pairs from extensor digitorum communis (EDC) muscle were recorded from each subject with trigger-delay line mode. Patients with motor neuron disorders (17.7 ± 10.8 ms) showed significantly higher mean time variability of interpotential interval value than healthy volunteers (10.3 ± 0.1 ms) (p < 0.001).
authors.affiliation: a Department of Neurology, Acibadem University School of Medicine , Istanbul , Turkey ;
authors.forename: Pınar
authors.initials: P
authors.lastname: Yalinay Dikmen
authors.affiliation: b Department of Neurology, Istanbul University, Istanbul Faculty of Medicine , Istanbul , Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Kocasoy Orhan
authors.affiliation: b Department of Neurology, Istanbul University, Istanbul Faculty of Medicine , Istanbul , Turkey.
authors.forename: M Barış
authors.initials: MB
authors.lastname: Baslo
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000328:Adult; D004558:Electric Stimulation; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000473:pathology*; D009046:Motor Neurons / Q000502:physiology*; D018482:Muscle, Skeletal / Q000473:pathology*; D018709:Statistics, Nonparametric
keywords: ALS; LMN; firing rate variability; interpotential intervals; motor neuron diseases; motor unit firing characteristics