title: Lamotrigine as monotherapy in clinical practice: efficacy of various dosages in epilepsy.
abstract: The study was designed to evaluate the optimal dosage of lamotrigine, as monotherapy, in the treatment of adults suffering from complex partial seizures with or without secondary generalization in everyday clinical practice.
  
  
  
  The ones used in this study was the collection of the data of all adult patients treated with lamotrigine, retrospectively. The dosage and efficacy of treatment were evaluated along with side effects and retention rate.
  
  
  
  They showed that, out of 188 patients, 77% continued lamotrigine treatment; the mean effective dose was 250 mg or higher of lamotrigine, and the results more pronounced in older patients (age above 30 years) and those with a longer disease duration (5 years and more).
  
  
  
  It may be appropriate to reach a daily lamotrigine dose above 250 mg in adult patients suffering from epilepsy for more than 5 years using lamotrigine as monotherapy.
authors.affiliation: Neurology Department E. Wolfson Medical Center HolonIsrael; Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel.
authors.forename: Anton
authors.initials: A
authors.lastname: Warshavsky
authors.affiliation: Neurology Department Kaplan Medical Center Hebrew University of Jerusalem Rehovot Israel.
authors.forename: Anda
authors.initials: A
authors.lastname: Eilam
authors.affiliation: Neurology Department Kaplan Medical Center Hebrew University of Jerusalem Rehovot Israel.
authors.forename: Ronit
authors.initials: R
authors.lastname: Gilad
mesh_terms: D000328:Adult; D004347:Drug Interactions; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014227:Triazines / Q000627:therapeutic use*
chemical_list: D014227:Triazines; D000077213:Lamotrigine
keywords: Dosage; efficacy; epilepsy; lamotrigine; monotherapy; seizures