title: Update on host-pathogen interactions in cystic fibrosis lung disease.
abstract: Bacterial and fungal infections are hallmarks of cystic fibrosis (CF) lung disease. In the era of long-term inhaled antibiotics and increasing CF patient survival, new "emerging" pathogens are detected in CF airways, yet their pathophysiological disease relevance remains largely controversial and incompletely defined. As a response to chronic microbial triggers, innate immune cells, particularly neutrophils, are continuously recruited into CF airways where they combat pathogens but also cause tissue injury through release of oxidants and proteases. The coordinated interplay between host immune cell activation and pathogens is essential for the outcome of CF lung disease. Here, we provide a concise overview and update on host-pathogen interactions in CF lung disease.
authors.affiliation: Department of Pediatrics I, University of Tübingen, Tübingen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Hector
authors.affiliation: Department of Pediatrics I, University of Tübingen, Tübingen, Germany.
authors.forename: Nina
authors.initials: N
authors.lastname: Frey
authors.affiliation: Department of Pediatrics I, University of Tübingen, Tübingen, Germany. Dominik.hartl@med.uni-tuebingen.de.
authors.forename: Dominik
authors.initials: D
authors.lastname: Hartl