title: Detection of Contaminants of High Environmental Impact by Means of Fluorogenic Probes.
abstract: This personal account describes our contribution to the design of selective fluorogenic probes for contaminants of high environmental impact. For this purpose, we have developed a new family of highly versatile fluorogenic reagents that were able to show large differences in their fluorescence in the presence of selected analytes. They were used in the preparation of fluorogenic probes for the detection of contaminants of high environmental impact which currently have no good solutions: phosphorylating agents, such as chemical weapons; methyl mercury(II); the cyanide anion; amino-acid metabolites, such as doping substances; and biogenic amine mimics, such as drugs of abuse and recreational drugs. The development of new materials for specific sensing was achieved by anchoring selected probes to silica nanomaterials, suitable for the selective detection of organic analytes in water for immediate application to toxicological or environmental purposes.
authors.affiliation: Department of Chemistry, University of Burgos, Faculty of Science, 09001, Burgos, Spain.
authors.forename: José
authors.initials: J
authors.lastname: García-Calvo
authors.affiliation: Department of Chemistry, University of Burgos, Faculty of Science, 09001, Burgos, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Calvo-Gredilla
authors.affiliation: Department of Chemistry, University of Burgos, Faculty of Science, 09001, Burgos, Spain.
authors.forename: Marcos
authors.initials: M
authors.lastname: Ibáñez-Llorente
authors.affiliation: Department of Chemistry, University of Burgos, Faculty of Science, 09001, Burgos, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Rodríguez
authors.affiliation: Department of Chemistry, University of Burgos, Faculty of Science, 09001, Burgos, Spain.
authors.forename: Tomás
authors.initials: T
authors.lastname: Torroba
mesh_terms: D000596:Amino Acids / Q000032:analysis; D001679:Biogenic Amines / Q000032:analysis; D002619:Chemical Warfare Agents / Q000032:analysis; D004785:Environmental Pollutants / Q000032:analysis*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis; D007192:Indenes / Q000737:chemistry*; D008767:Methylmercury Compounds / Q000032:analysis
chemical_list: D000596:Amino Acids; D001679:Biogenic Amines; D002619:Chemical Warfare Agents; D004785:Environmental Pollutants; D005456:Fluorescent Dyes; D013287:Illicit Drugs; D007192:Indenes; D008767:Methylmercury Compounds
keywords: amino acids; biogenic amines; cyanides; fluorescent probes; nerve agents