title: Helicobacter pylori CagL Hypervariable Motif: A Global Analysis of Geographical Diversity and Association With Gastric Cancer.
abstract: Previous studies suggest overrepresentation of particular polymorphisms within the Helicobacter pylori CagL hypervariable motif (CagLHM) in gastric cancer-associated isolates. However, these disease correlations were geographically variable and ambiguous. We compared the disease correlation of several hundred geographically diverse CagL sequences and identified 33 CagLHM sequence combinations with disparate geographical distribution, revealing substantial worldwide CagLHM diversity, particularly within Asian countries. Notably, polymorphisms E59 and I60 were significantly overrepresented, whereas D58 and E62 were underrepresented, in gastric cancer-associated H. pylori isolates worldwide. Thus, CagLHM regional diversity may contribute to the varied prevalence of H. pylori-related gastric cancer observed in diverse populations.
authors.affiliation: Infection and Immunity Program Cancer Program, Monash Biomedicine Discovery Institute Department of Biochemistry and Molecular Biology Department of Microbiology.
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Gorrell
authors.affiliation: Infection and Immunity Program Cancer Program, Monash Biomedicine Discovery Institute Department of Biochemistry and Molecular Biology.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Zwickel
authors.affiliation: Biostatistics Consulting Platform, Faculty of Medicine, Nursing and Health Sciences, Monash University and the Alfred Centre, Melbourne Clinical Haematology, The Alfred, Prahran.
authors.forename: John
authors.initials: J
authors.lastname: Reynolds
authors.affiliation: Victorian Bioinformatics Consortium, Monash University, Clayton Life Sciences Computation Centre, Victorian Life Sciences Computation Initiative, Carlton, Australia.
authors.forename: Dieter
authors.initials: D
authors.lastname: Bulach
authors.affiliation: Infection and Immunity Program Cancer Program, Monash Biomedicine Discovery Institute Department of Biochemistry and Molecular Biology Department of Microbiology.
authors.forename: Terry
authors.initials: T
authors.lastname: Kwok
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000235:genetics; D001208:Asia / Q000453:epidemiology; D001426:Bacterial Proteins / Q000235:genetics*; D014943:Global Health; D016481:Helicobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification; D054884:Host-Pathogen Interactions; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D015995:Prevalence; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C568315:cagL protein, Helicobacter pylori
keywords: CagL; Helicobacter pylori; gastric cancer; gastritis; geographical diversity; host/pathogen co-evolution; host/pathogen interaction; integrin; peptic ulcer disease; sequence polymorphism