title: Correlation between the plasma fibrinogen concentration and coronary heart disease severity in Moroccan patients with type 2 diabetes. Prospective study.
abstract: OBJECTIVE
  The present study aims at determining the relationship between the plasma fibrinogen concentration and the severity of coronary heart disease in type 2 diabetic patients.
  
  
  METHODS
  Prospective analytical survey, based on a sample of 120 subjects divided in four groups: 30 non diabetic coronary patients (G1), 30 coronary diabetic patients (G2), 30 non-coronary diabetic patients (G3), and 30 healthy subjects (G4).
  
  
  RESULTS
  The average age was 59.58±7.88 years; female gender predominated by 52.5%. The plasma fibrinogen concentration corresponded to 3.46g/L±0.86 in G1; 3.73g/L±1.11 in G2; 3.06g/L±0.98 in G3 and 2.46g/L±0.51 in G4; with a significant difference between the four groups (P=0.001). The plasma fibrinogen concentration increased in parallel with the cardiovascular risk (P=0.0001); there was also a significant correlation between the plasma fibrinogen concentration and the clinical and para-clinical coronary disease severity (respectively P=0.005 and P=0.0001). A positive correlation between the plasma fibrinogen concentration and hyperglycemia (P=0.035) was found in G4. But no correlation with the lipids parameters, except for the low density-lipoproteins in G3 (P=0.035).
  
  
  CONCLUSIONS
  In the Moroccan population, the plasma fibrinogen concentration was positively and significantly correlated with the coronary heart disease severity.
authors.affiliation: Department of Biology, Laboratory of Biochemistry and Molecular Biology, Ain chock Faculty of Science, Km 9, El Jadida road, Box 5366 Maarif, Casablanca, Morocco.
authors.forename: Souad
authors.initials: S
authors.lastname: Kotbi
authors.affiliation: Endocrinology and Metabolic Diseases department, Ibn Rochd, University Hospital Center 1, Hospitals part, Casablanca, Morocco.
authors.forename: Amal
authors.initials: A
authors.lastname: Mjabber
authors.affiliation: Endocrinology and Metabolic Diseases department, Ibn Rochd, University Hospital Center 1, Hospitals part, Casablanca, Morocco. Electronic address: drachadli@gmail.com.
authors.forename: Asma
authors.initials: A
authors.lastname: Chadli
authors.affiliation: Cardiology department, Ibn Rochd university, Hospital Center, 1, Hospitals part, Casablanca, Morocco.
authors.forename: Ayoub
authors.initials: A
authors.lastname: El Hammiri
authors.affiliation: Endocrinology and Metabolic Diseases department, Ibn Rochd, University Hospital Center 1, Hospitals part, Casablanca, Morocco.
authors.forename: Siham
authors.initials: S
authors.lastname: El Aziz
authors.affiliation: Regional blood transfusion centre, 1, Mohamed El Fidouzi-ex Jenner street, Casablanca, Morocco.
authors.forename: Bouchra
authors.initials: B
authors.lastname: Oukkache
authors.affiliation: Hematology laboratory, Ibn Rochd university, Hospital Center, Hospitals part, Casablanca, Morocco.
authors.forename: Hassan
authors.initials: H
authors.lastname: Mifdal
authors.affiliation: Hematology laboratory, Ibn Rochd university, Hospital Center, Hospitals part, Casablanca, Morocco.
authors.forename: Nadia
authors.initials: N
authors.lastname: Nourichafi
authors.affiliation: Laboratory of biochemistry, Ibn Rochd university, Hospital Center, 1, Hospitals part, Casablanca, Morocco.
authors.forename: Nabiha
authors.initials: N
authors.lastname: Kamal
authors.affiliation: Cardiology department, Ibn Rochd university, Hospital Center, 1, Hospitals part, Casablanca, Morocco.
authors.forename: Rachida
authors.initials: R
authors.lastname: Habbal
authors.affiliation: Department of medical biology, Pasteur Institute of Morocco, 1, place Louis-Pasteur, 20360 Casablanca, Morocco.
authors.forename: Norredine
authors.initials: N
authors.lastname: Ghalim
authors.affiliation: Endocrinology and Metabolic Diseases department, Ibn Rochd, University Hospital Center 1, Hospitals part, Casablanca, Morocco.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Farouqi
authors.affiliation: Department of Biology, Laboratory of Biochemistry and Molecular Biology, Ain chock Faculty of Science, Km 9, El Jadida road, Box 5366 Maarif, Casablanca, Morocco.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Kabine
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000097:blood* / Q000453:epidemiology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009018:Morocco / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D005340:Fibrinogen
keywords: Cardiovascular disease; Coronary lesions; Diabète de type 2; Fibrinogen; Fibrinogène; Lésions coronaires; Maladie cardiovasculaire; Type 2 diabetes