title: Asthma in childhood.
abstract: Several topics on childhood asthma were addressed in the Paediatric Clinical Year in Review session at the 2015 European Respiratory Society International Congress. With regard to the relationship between lower respiratory tract infections and asthma, it emerges that is the number of respiratory episodes in the first years of life, but not the particular viral trigger, to be associated with later asthma development. Understanding which characteristics of individual patients are associated with an increased risk for asthma exacerbation is a critical step to implement strategies preventing these seasonal events. Recent data suggest the possibility that exhaled volatile organic compounds may qualify as biomarkers in detecting early signs of asthma. Adding information of exhaled volatile organic compounds and expression of inflammation genes to a clinical tool significantly improves asthma prediction in preschool wheezy children. Personal communication with children and adolescents is likely more important than the tools actually used for monitoring asthma. Systemic corticosteroids do not affect the long-term prognosis in children with first viral-induced wheezing episode and should be used cautiously during acute episodes. Finally, stress and a polymorphism upstream of a specific gene are both associated with reduced bronchodilator response in children with asthma.
authors.affiliation: Dept of Pediatrics, Salesi Children's Hospital, Ancona, Italy pediatria@fmdebenedictis.it.
authors.forename: Fernando Maria
authors.initials: FM
authors.lastname: de Benedictis
authors.affiliation: Dept of Paediatrics, University of Chieti, Chieti, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Attanasi
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D011237:Predictive Value of Tests; D011379:Prognosis; D012141:Respiratory Tract Infections / Q000453:epidemiology; D012307:Risk Factors; D013256:Steroids / Q000627:therapeutic use
chemical_list: D018927:Anti-Asthmatic Agents; D013256:Steroids