title: Ocular Toxicity of Tyrosine Kinase Inhibitors.
abstract: OBJECTIVE
  To review common tyrosine kinase inhibitors, as well as their ocular side effects and management. .
  
  
  METHODS
  A comprehensive literature search was conducted using CINAHL®, PubMed, and Cochrane databases for articles published since 2004 with the following search terms.
  
  
  RESULTS
  Tyrosine kinase inhibitors can cause significant eye toxicity. .
  
  
  CONCLUSIONS
  Given the prevalence of new tyrosine kinase inhibitor therapies and the complexity of possible pathogenesis of ocular pathology, oncology nurses can appreciate the occurrence of ocular toxicities and the role of nursing in the management of these problems. .
  
  
  CONCLUSIONS
  Knowledge of the risk factors and etiology of ocular toxicity of targeted cancer therapies can guide nursing assessment, enhance patient education, and improve care management. Including a review of eye symptoms and vision issues in nursing assessment can enhance early detection and treatment of ocular toxicity.
authors.affiliation: Department of Ambulatory Nursing, Memorial Sloan-Kettering Cancer Center, New York, NY.
authors.forename: Mary Elizabeth
authors.initials: ME
authors.lastname: Davis
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000451:nursing* / Q000517:prevention & control*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D009859:Oncology Nursing / Q000379:methods*; D011505:Protein-Tyrosine Kinases / Q000009:adverse effects*; D012307:Risk Factors; D014785:Vision, Ocular / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D011505:Protein-Tyrosine Kinases
keywords: ocular; ophthalmology; targeted therapy; toxicity; tyrosine kinase inhibitors