title: Effects of Elaeagnus angustifolia L. on Lipid Profile and Atherogenic Indices in Obese Females: A Randomized Controlled Clinical Trial.
abstract: In the present randomized double-blinded placebo-controlled study, the effect of Elaeagnus angustifolia L. (EA) whole fruit and medulla powders on anthropometric indices, serum lipid profile, and atherogenic indices in females with knee osteoarthritis (OA) was investigated. Ninety females with mild to moderate knee osteoarthritis were randomly assigned to one of three groups-medulla powder, whole fruit powder, or placebo. The subjects received 15 g/day of medulla powder of EA, whole fruit powder of EA, or placebo. Lipid profile, weight, and dietary intake were measured at baseline and at the end of the study. Body mass index and atherogenic indices were calculated. Statistical analysis was performed using SPSS version 13.0, and Paired t tests, analysis of variance (ANOVA), analysis of covariance (ANCOVA), and the Tukey post hoc test were used to compare within-group and between-group values. After 8 weeks of supplementations, compared with the baseline, significant reductions in total cholesterol (TC), low density lipoprotein/high density lipoprotein (LDL/HDL), and TC/HDL ratios were observed in the two supplemented groups; however, the reduction of these values was not statistically significant in the placebo group. There were significant differences between the patients who received medulla powder and placebo group in the case of changes in TC/HDL and LDL/HDL ratios (p < .001). However, no significant differences were found between the two supplemented groups in the case of changes in studied values (p > .05). Generally, whole fruit and medulla powders of Elaeagnus angustifolia L. had positive effects, especially in decreasing total cholesterol and atherogenic indices in females with knee OA.
authors.affiliation: a Liver and Gastrointestinal Diseases Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Nikniaz
authors.affiliation: b Nutrition Research Centre , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Mahdavi
authors.affiliation: c Tabriz Health Services Management Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Nikniaz
authors.affiliation: d Connective Tissue Diseases Research Centre , Tabriz University of Medical Sciences, Imam Reza Hospital , Tabriz , Iran.
authors.forename: Aliasghar
authors.initials: A
authors.lastname: Ebrahimi
authors.affiliation: b Nutrition Research Centre , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Ostadrahimi
mesh_terms: D000328:Adult; D000368:Aged; D000700:Analgesics; D000886:Anthropometry; D050197:Atherosclerosis / Q000097:blood / Q000188:drug therapy*; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D004311:Double-Blind Method; D031263:Elaeagnaceae / Q000737:chemistry*; D005260:Female; D005638:Fruit / Q000737:chemistry; D006801:Humans; D007492:Iran; D007719:Knee Joint; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D010003:Osteoarthritis / Q000188:drug therapy / Q000503:physiopathology; D008517:Phytotherapy; D010919:Placebos; D010936:Plant Extracts / Q000008:administration & dosage
chemical_list: D000700:Analgesics; D008055:Lipids; D010919:Placebos; D010936:Plant Extracts; D002784:Cholesterol
keywords: Elaeagnus angustifolia L.; anthropometric indices; atherogenic indices; females; lipid profile; osteoarthritis