title: The Effect of Dietary Supplementation With Curcumin on Redox Status and Nrf2 Activation in Patients With Nondiabetic or Diabetic Proteinuric Chronic Kidney Disease: A Pilot Study.
abstract: Chronic kidney disease (CKD) is a worldwide public health problem, and proteinuria may accelerate the progression of CKD, being oxidative stress a common mechanism in nondiabetic or diabetic proteinuric kidney disease. This study was designed to evaluate the effect of the dietary supplementation with curcumin (CUR) on the redox status and the nuclear factor erythroid 2-related factor 2 (Nrf2) activation in patients with nondiabetic or diabetic proteinuric CKD.
  
  
  
  Randomized double-blind placebo-controlled clinical trial.
  
  
  
  A total of 101 Mexican patients from the National Institute of Cardiology "Ignacio Chavez", with nondiabetic or diabetic proteinuric CKD (proteinuria ≥ 1 g protein/24 hours), aged 20 to 70 years; 60% were male, and 51% were diabetic.
  
  
  
  Patients with nondiabetic proteinuric CKD received placebo (n = 26) or CUR 320 mg/day (n = 24) for 8 weeks, and patients with diabetic proteinuric CKD were intervened with placebo (n = 23) or CUR 320 mg/day (n = 28) for the same period.
  
  
  
  Anthropometrical, clinical, and biochemical characteristics, as well as oxidative stress markers, antioxidant enzyme activities and Nrf2 activation were evaluated at baseline and after intervention.
  
  
  
  The intervention with CUR did not improve proteinuria, estimated glomerular filtration rate, or lipid profile. However, in plasma, CUR attenuated lipid peroxidation in individuals with nondiabetic proteinuric CKD (P<.05) and enhanced the antioxidant capacity in subjects with diabetic proteinuric CKD (P<.05). No effect of CUR was observed on the antioxidant enzymes activities or Nrf2 activation.
  
  
  
  Dietary supplementation with CUR has the potential to reduce oxidative stress in Mexican patients with nondiabetic or diabetic proteinuric CKD. Studies with higher doses of CUR and longer follow-up are granted to confirm our findings.
authors.affiliation: Department of Biology, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.
authors.forename: Angélica Saraí
authors.initials: AS
authors.lastname: Jiménez-Osorio
authors.affiliation: Department of Biology, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.
authors.forename: Wylly Ramsés
authors.initials: WR
authors.lastname: García-Niño
authors.affiliation: Department of Biology, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.
authors.forename: Susana
authors.initials: S
authors.lastname: González-Reyes
authors.affiliation: Department of Biology, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.
authors.forename: Alejandra Elizabeth
authors.initials: AE
authors.lastname: Álvarez-Mejía
authors.affiliation: Department of Biology, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.
authors.forename: Sebastián
authors.initials: S
authors.lastname: Guerra-León
authors.affiliation: Department of Nephrology, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Salazar-Segovia
authors.affiliation: Department of Nephrology, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.
authors.forename: Ilse
authors.initials: I
authors.lastname: Falcón
authors.affiliation: Department of Nephrology, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.
authors.forename: Héctor
authors.initials: H
authors.lastname: Montes de Oca-Solano
authors.affiliation: Department of Nephrology, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Madero
authors.affiliation: Department of Biology, National Autonomous University of Mexico (UNAM), Mexico City, Mexico. Electronic address: pedraza@unam.mx.
authors.forename: José
authors.initials: J
authors.lastname: Pedraza-Chaverri
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D030024:Curcuma / Q000737:chemistry; D003474:Curcumin / Q000008:administration & dosage*; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D051267:NF-E2-Related Factor 2 / Q000235:genetics / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D011507:Proteinuria / Q000188:drug therapy*; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D003474:Curcumin