title: Expression of nectin-4 as a potential biomarker in enzootic nasal adenocarcinoma of goats.
abstract: The aim of this study was to test nectin-4 by immunohistochemistry as a potential biomarker in enzootic nasal adenocarcinoma (ENA) of goats. Twentyfour archival ENA case samples [from 14 male and 10 female hair goats (Capra hircus)] were used. The samples were stained with haematoxylin and eosin (HE). Nectin-4 expression was studied by immunohistochemistry. By microscopy, tubular, papillary, and mixed patterns of ENA were diagnosed in the cases. Immunohistochemically, the tumours showed moderate nectin-4 expression (++) in 14 cases (58.3%), strong expression (+++) in five cases (20.8%), and weak expression (+) in three cases (12.5%), while two cases (8.3%) were negative. Normal nasal tissues were not stained with nectin-4. The results suggest that nectin-4 may be used as a valuable biomarker of ENA.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University , 15030 Burdur , Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Aydoğan
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University , 15030 Burdur , Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Özmen
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D015511:Goat Diseases / Q000473:pathology*; D006041:Goats; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D000075983:Nectins / Q000378:metabolism*; D009669:Nose Neoplasms / Q000473:pathology / Q000662:veterinary*
chemical_list: D015415:Biomarkers; D000075983:Nectins
keywords: Goat; enzootic nasal adenocarcinoma; immunohistochemistry; nectin-4; pathology