title: T Regulatory Cell Biology in Health and Disease.
abstract: Regulatory T (Treg) cells that express the transcription factor forkhead box protein P3 (FOXP3) play an essential role in enforcing immune tolerance to self tissues, regulating host-commensal flora interaction, and facilitating tissue repair. Their deficiency and/or dysfunction trigger unbridled autoimmunity and inflammation. A growing number of monogenic defects have been recognized that adversely impact Treg cell development, differentiation, and/or function, leading to heritable diseases of immune dysregulation and autoimmunity. In this article, we review recent insights into Treg cell biology and function, with particular attention to lessons learned from newly recognized clinical disorders of Treg cell deficiency.
authors.affiliation: Division of Immunology, Boston Children's Hospital, Karp Family Building, Room 10-214. 1 Blackfan Street, Boston, MA, 02115, USA.
authors.forename: Fayhan J
authors.initials: FJ
authors.lastname: Alroqi
authors.affiliation: Division of Immunology, Boston Children's Hospital, Karp Family Building, Room 10-214. 1 Blackfan Street, Boston, MA, 02115, USA. talal.chatila@childrens.harvard.edu.|Department of Pediatrics, Harvard Medical School, Boston, MA, USA. talal.chatila@childrens.harvard.edu.
authors.forename: Talal A
authors.initials: TA
authors.lastname: Chatila
mesh_terms: D003585:Cell Biology; D002454:Cell Differentiation / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000151:congenital* / Q000378:metabolism; D003967:Diarrhea / Q000378:metabolism*; D051858:Forkhead Transcription Factors / Q000378:metabolism; D040181:Genetic Diseases, X-Linked / Q000378:metabolism*; D006801:Humans; D007154:Immune System Diseases / Q000151:congenital* / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors
keywords: Autoimmunity; IPEX; IPEX like; Immune dysregulation; Regulatory T (Treg) cell; T conventional cell (Tconv)