title: Early Hypoalbuminemia is an Independent Predictor of Mortality in Aneurysmal Subarachnoid Hemorrhage.
abstract: Hypoalbuminemia has been identified as a predictor of morbidity and mortality in critically ill patients. There is very little data on the significance and the prognostic value of hypoalbuminemia in patients with aneurysmal subarachnoid hemorrhage (aSAH). This study analyzed the impact of hypoalbuminemia on patient presentation, complications, and outcomes.
  
  
  
  Records of patients admitted with aSAH were examined. Data on baseline characteristics, prevalence of delayed cerebral ischemia, and discharge outcomes were collected. Multivariable logistic regression analysis was performed to assess for associations.
  
  
  
  One-hundred and forty-two patients comprised the study cohort (mean age 54.6 ± 13.4), among which 45 (31.5 %) presented with hypoalbuminemia. No difference in baseline characteristics was noted between patients with hypoalbuminemia and those with normal serum albumin. The overall hospital mortality rate was significantly higher in patients with hypoalbuminemia, compared to those with normal albumin (28.9 % vs. 11.3 %; p = 0.04). Hypoalbuminemia was neither associated with delayed cerebral ischemia nor disability at discharge, but independently associated with in-hospital death (odds ratio: 4.26, 95 % confidence interval: 1.09-16.68; p = 0.04).
  
  
  
  In patients with aSAH, early hypoalbuminemia is an independent predictor of hospital mortality but not disability at discharge.
authors.affiliation: Division of Cerebrovascular Diseases, Department of Neurology, School of Medicine, Medical Arts & Research Center, University of Texas Health Science Center, 8300 Floyd Curl Drive, MC 7883, San Antonio, TX, 78229, USA. behrouz@uthscsa.edu.
authors.forename: Réza
authors.initials: R
authors.lastname: Behrouz
authors.affiliation: The Neurointensive Care Unit, Sanatorio Pasteur, Catamarca, Argentina.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Godoy
authors.affiliation: Division of Cerebrovascular Diseases, Department of Neurology, School of Medicine, Medical Arts & Research Center, University of Texas Health Science Center, 8300 Floyd Curl Drive, MC 7883, San Antonio, TX, 78229, USA.
authors.forename: Christopher Hans
authors.initials: CH
authors.lastname: Topel
authors.affiliation: Division of Cerebrovascular Diseases, Department of Neurology, School of Medicine, Medical Arts & Research Center, University of Texas Health Science Center, 8300 Floyd Curl Drive, MC 7883, San Antonio, TX, 78229, USA.|Department of Neurological Surgery, School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Lee A
authors.initials: LA
authors.lastname: Birnbaum
authors.affiliation: Department of Neurological Surgery, School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Caron
authors.affiliation: Department of Neurological Surgery, School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Grandhi
authors.affiliation: Department of Neurological Surgery, School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Jeremiah N
authors.initials: JN
authors.lastname: Johnson
authors.affiliation: Division of Cerebrovascular Diseases, Department of Neurology, School of Medicine, Medical Arts & Research Center, University of Texas Health Science Center, 8300 Floyd Curl Drive, MC 7883, San Antonio, TX, 78229, USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Misra
authors.affiliation: Department of Neurological Surgery, School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Seifi
authors.affiliation: Department of Medical Informatics, University Hospital, San Antonio, TX, USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Urbansky
authors.affiliation: Neurological Service, San Camillo de' Lellis General Hospital, Rieti, Italy.|Neurological Section, SMDN-Center for Cardiovascular Medicine and Cerebrovascular Disease, Sulmona, L'Aquila, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Di Napoli
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia / Q000097:blood*; D002532:Intracranial Aneurysm / Q000150:complications*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000209:etiology / Q000401:mortality*
keywords: Albumin; Critical are; Hypoalbuminemia; Subarachnoid hemorrhage