title: The Lysobacter capsici AZ78 Genome Has a Gene Pool Enabling it to Interact Successfully with Phytopathogenic Microorganisms and Environmental Factors.
abstract: Lysobacter capsici AZ78 has considerable potential for biocontrol of phytopathogenic microorganisms. However, lack of information about genetic cues regarding its biological characteristics may slow down its exploitation as a biofungicide. In order to obtain a comprehensive overview of genetic features, the L. capsici AZ78 genome was sequenced, annotated and compared with the phylogenetically related pathogens Stenotrophomonas malthophilia K729a and Xanthomonas campestris pv. campestris ATCC 33913. Whole genome comparison, supported by functional analysis, indicated that L. capsici AZ78 has a larger number of genes responsible for interaction with phytopathogens and environmental stress than S. malthophilia K729a and X. c. pv. campestris ATCC 33913. Genes involved in the production of antibiotics, lytic enzymes and siderophores were specific for L. capsici AZ78, as well as genes involved in resistance to antibiotics, environmental stressors, fungicides and heavy metals. The L. capsici AZ78 genome did not encompass genes involved in infection of humans and plants included in the S. malthophilia K729a and X. c. pv. campestris ATCC 33913 genomes, respectively. The L. capsici AZ78 genome provides a genetic framework for detailed analysis of other L. capsici members and the development of novel biofungicides based on this bacterial strain.
authors.affiliation: Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach San Michele all'Adige, Italy.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Puopolo
authors.affiliation: Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund MachSan Michele all'Adige, Italy; Department of Agricultural and Environmental Science (DISA), PhD School of Agricultural Science and Biotechnology, University of UdineUdine, Italy.
authors.forename: Selena
authors.initials: S
authors.lastname: Tomada
authors.affiliation: Department of Computational Biology, Research and Innovation Centre, Fondazione Edmund Mach San Michele all'Adige, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Sonego
authors.affiliation: Department of Computational Biology, Research and Innovation Centre, Fondazione Edmund Mach San Michele all'Adige, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Moretto
authors.affiliation: Department of Computational Biology, Research and Innovation Centre, Fondazione Edmund Mach San Michele all'Adige, Italy.
authors.forename: Kristof
authors.initials: K
authors.lastname: Engelen
authors.affiliation: Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach San Michele all'Adige, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Perazzolli
authors.affiliation: Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach San Michele all'Adige, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Pertot
keywords: Lysobacter; biological control; environmental stress; lytic enzymes; siderophores