title: Effects of quercetin on pharmacokinetics of cefprozil in Chinese-Han male volunteers.
abstract: 1. The primary objective of this study was to evaluate the effects of quercetin on the pharmacokinetics of cefprozil. The secondary objective was to evaluate the safety of the combined use of cefprozil and quercetin. 2. An open-label, two-period, crossover phase I trial among 24 Han Chinese male subjects was conducted. Participants were given 500 mg of quercetin orally once daily for 15 d followed by single dose of cefprozil (500 mg) on day 15. Serum concentrations of cefprozil were then measured in all participants on day 15. A 15-d washout period was then assigned after which a 500 mg dose of cefprozil was administered and measured in the serum on day 36. 3. All subjects completed the trial, and no serious adverse events were reported. We measured mean serum concentrations of cefprozil in the presence and absence of quercetin in all participants. The maximum serum concentration of cefprozil in the presence of quercetin was 8.18 ug/ml (95% CI: 7.55-8.81) versus a maximum cefprozil concentration of 8.35 ug/ml (95% CI: 7.51-9.19) in the absence of quercetin. We conclude that the concurrent use of quercetin has no substantial effect on serum concentrations of orally administered cefprozil. 4. Co-administration of quercetin showed no statistically significant effects on the pharmacokinetics of cefprozil in healthy Chinese subjects.
authors.affiliation: a Department of Clinical Pharmacology , Xiangya Hospital, Central South University , Changsha , China .|b Department of Cancer Epidemiology , DeBartolo Family Personalized Medicine Institute, Moffitt Cancer Center , Tampa , FL , USA , and.|c Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University , Changsha , China.
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Jia
authors.affiliation: a Department of Clinical Pharmacology , Xiangya Hospital, Central South University , Changsha , China .|c Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University , Changsha , China.
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Tan
authors.affiliation: a Department of Clinical Pharmacology , Xiangya Hospital, Central South University , Changsha , China .|b Department of Cancer Epidemiology , DeBartolo Family Personalized Medicine Institute, Moffitt Cancer Center , Tampa , FL , USA , and.
authors.forename: Howard L
authors.initials: HL
authors.lastname: McLeod
authors.affiliation: a Department of Clinical Pharmacology , Xiangya Hospital, Central South University , Changsha , China .|c Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University , Changsha , China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: a Department of Clinical Pharmacology , Xiangya Hospital, Central South University , Changsha , China .|c Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University , Changsha , China.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Ou-Yang
authors.affiliation: a Department of Clinical Pharmacology , Xiangya Hospital, Central South University , Changsha , China .|c Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University , Changsha , China.
authors.forename: Hong-Hao
authors.initials: HH
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D000975:Antioxidants / Q000494:pharmacology*; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D006801:Humans; D008297:Male; D011794:Quercetin / Q000494:pharmacology*; D014838:Volunteers; D000097670:Cefprozil
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D002511:Cephalosporins; D011794:Quercetin; D000097670:Cefprozil
keywords: Drug–drug interaction; healthy subjects; pharmacokinetics; quercetin; transporters