title: C-C motif ligand 11 reduction in CLL patients serum after vitamin D supplementation.
abstract: BACKGROUND
  Vitamin D (VD) deficiency results in a worse prognosis in patients with chronic lymphocytic leukemia (CLL) and may affect the production of cytokines. Nonetheless, there is the lack of studies dealing with VD supplementation and its impact on chemokines in CLL patients.
  
  
  OBJECTIVE
  The primary endpoint of our interventional study was to evaluate the effect of cholecalciferol supplementation on serum chemokines levels in CLL patients.
  
  
  METHODS
  Eighteen subjects with CLL were enrolled for the study. Six-month-long cholecalciferol supplementation was performed in CLL patients with serum 25-OH-D3 levels below 30 ng/ml. Cytokines levels were assessed at the beginning of the study and after 6 months. Baseline measurements of cytokines were compared to those in apparently healthy controls.
  
  
  RESULTS
  Increased levels of CCL2, CCL3, CCL4, CXCL8, CXCL10, TNFα, bFGF, G-CSF, and VEGF were found in CLL patients in comparison with the healthy controls. In the course of the VD supplementation a decrease in serum levels of chemokines CCL11, CCL3, and cytokine PDGF-BB was observed. The decrease of CCL11 was found in CLL patients on VD supplementation solely, whereas the decrease of CCL3 and PDGF-BB was observed in CLL subjects on both chemotherapy and VD supplementation.
  
  
  CONCLUSIONS
  The VD supplementation may exert beneficial effect on chemokines levels in CLL patients with VD deficiency.
authors.affiliation: a Clinical and Experimental Oncology Department , Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology , Gliwice Branch, Gliwice 44-400 , Poland.|b Department of Internal Medicine and Oncological Chemotherapy, School of Medicine in Katowice , Medical University of Silesia , Katowice 40-027 , Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Kubeczko
authors.affiliation: a Clinical and Experimental Oncology Department , Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology , Gliwice Branch, Gliwice 44-400 , Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Nowara
authors.affiliation: b Department of Internal Medicine and Oncological Chemotherapy, School of Medicine in Katowice , Medical University of Silesia , Katowice 40-027 , Poland.
authors.forename: Dobromiła
authors.initials: D
authors.lastname: Karwasiecka
authors.affiliation: b Department of Internal Medicine and Oncological Chemotherapy, School of Medicine in Katowice , Medical University of Silesia , Katowice 40-027 , Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Siewior
authors.affiliation: b Department of Internal Medicine and Oncological Chemotherapy, School of Medicine in Katowice , Medical University of Silesia , Katowice 40-027 , Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Czajka-Francuz
authors.affiliation: b Department of Internal Medicine and Oncological Chemotherapy, School of Medicine in Katowice , Medical University of Silesia , Katowice 40-027 , Poland.|c Department of Pathophysiology, School of Medicine in Katowice , Medical University of Silesia , Katowice 40-752 , Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Chudek
authors.affiliation: b Department of Internal Medicine and Oncological Chemotherapy, School of Medicine in Katowice , Medical University of Silesia , Katowice 40-027 , Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Wojnar
mesh_terms: D000368:Aged; D018925:Chemokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000097:blood
chemical_list: D018925:Chemokines; D014807:Vitamin D
keywords: Chemokine; Chronic lymphocytic leukemia; Vitamin D