title: Plasma NT-proBNP is independently associated with albuminuria in type 2 diabetes.
abstract: OBJECTIVE
  The aim of this study is to investigate the relationship between plasma NH2-terminal pro-brain natriuretic peptide (NT-proBNP) levels and diabetic nephropathy in type 2 diabetic patients.
  
  
  METHODS
  The records of 983 patients with type 2 diabetes hospitalized in the Endocrinology and Metabolism Department of Peking University People's Hospital between January 2009 and December 2012 were reviewed. Based on their urinary albumin-to-creatinine ratio (UACR), the subjects were divided into three groups, those with normal, micro- and macro-albuminuria. Clinical manifestations and biochemical parameters, including plasma NT-proBNP concentrations, were compared between the three groups. The association between plasma NT-proBNP levels and stages of diabetic nephropathy was also evaluated by ordinal and stepwise linear regression analyses.
  
  
  RESULTS
  The median plasma NT-proBNP concentration in the 983 patients with type 2 diabetes was 60.3 pg/ml, which is within the normal range of healthy subjects. One-way ANOVA analysis showed significant differences in plasma NT-proBNP concentrations among the three groups (p=0.000). Ordinal logistic regression analysis showed that plasma NT-proBNP concentration was an independent risk factor for advanced diabetic nephropathy (odds ratio=1.87,95% CI 1.52-2.29, p=0.000). Plasma NT-proBNP concentration was highly correlated with UACR (r=0.421, p=0.000) and had an independently positive association with UACR by stepwise linear regression analysis (p=0.000).
  
  
  CONCLUSIONS
  Plasma NT-proBNP levels correlated with the degree of diabetic nephropathy in patients with type 2 diabetes.
authors.affiliation: Peking University People's Hospital, Beijing, China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Peking University People's Hospital, Beijing, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Cai
authors.affiliation: Peking University People's Hospital, Beijing, China.
authors.forename: Minghui
authors.initials: M
authors.lastname: Li
authors.affiliation: Peking University People's Hospital, Beijing, China.
authors.forename: Xueyao
authors.initials: X
authors.lastname: Han
authors.affiliation: Peking University People's Hospital, Beijing, China. Electronic address: jiln@bjmu.edu.cn.
authors.forename: Linong
authors.initials: L
authors.lastname: Ji
mesh_terms: D000419:Albuminuria / Q000209:etiology*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000652:urine; D003925:Diabetic Angiopathies / Q000150:complications / Q000453:epidemiology; D003928:Diabetic Nephropathies / Q000150:complications / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000150:complications / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006785:Hospitals, University; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D006442:Glycated Hemoglobin; D020097:Natriuretic Peptide, Brain; D010446:Peptide Fragments; C517652:hemoglobin A1c protein, human; C109794:pro-brain natriuretic peptide (1-76)
keywords: Chronic kidney disease; Diabetic nephropathy; NT-proBNP; Type 2 diabetes; Urinary albumin-to-creatinine ratio