title: d-Allulose supplementation normalized the body weight and fat-pad mass in diet-induced obese mice via the regulation of lipid metabolism under isocaloric fed condition.
abstract: A number of findings suggest that zero-calorie d-allulose, also known as d-psicose, has beneficial effects on obesity-related metabolic disturbances. However, it is unclear whether d-allulose can normalize the metabolic status of diet-induced obesity without having an impact on the energy density. We investigated whether 5% d-allulose supplementation in a high fat diet(HFD) could normalize body fat in a diet-induced obesity animal model under isocaloric pair-fed conditions.
  
  
  
  Mice were fed an HFD with or without various sugar substitutes (d-glucose, d-fructose, erytritol, or d-allulose, n = 10 per group) for 16 wk. Body weight and fat-pad mass in the d-allulose group were dramatically lowered to that of the normal group with a simultaneous decrease in plasma leptin and resistin concentrations. d-allulose lowered plasma and hepatic lipids while elevating fecal lipids with a decrease in mRNA expression of CD36, ApoB48, FATP4, in the small intestine in mice. In the liver, activities of both fatty acid synthase and β-oxidation were downregulated by d-allulose to that of the normal group; however, in WAT, fatty acid synthase was decreased while β-oxidation activity was enhanced.
  
  
  
  Taken together, our findings suggest that 5% dietary d-allulose led to the normalization of the metabolic status of diet-induced obesity by altering lipid-regulating enzyme activities and their gene-expression level along with fecal lipids.
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Youngji
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Han
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Ae-Hyang
authors.initials: AH
authors.lastname: Kim
authors.affiliation: Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Su-Jung
authors.initials: SJ
authors.lastname: Cho
authors.affiliation: Institute of Genetic Engineering, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Yong Bok
authors.initials: YB
authors.lastname: Park
authors.affiliation: Department of Food Science and Nutrition, Pukyong National University, Busan, Republic of Korea.
authors.forename: Un Ju
authors.initials: UJ
authors.lastname: Jung
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.|Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
mesh_terms: D050154:Adiposity / Q000187:drug effects; D000818:Animals; D053283:Apolipoprotein B-48 / Q000235:genetics / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects*; D018955:CD36 Antigens / Q000235:genetics / Q000378:metabolism; D059305:Diet, High-Fat; D019587:Dietary Supplements; D050612:Fatty Acid Transport Proteins / Q000235:genetics / Q000378:metabolism; D005632:Fructose / Q000008:administration & dosage*; D005786:Gene Expression Regulation; D005947:Glucose / Q000008:administration & dosage; D020738:Leptin / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology; D052243:Resistin / Q000097:blood; D013549:Sweetening Agents / Q000008:administration & dosage
chemical_list: D053283:Apolipoprotein B-48; D001786:Blood Glucose; D018955:CD36 Antigens; D050612:Fatty Acid Transport Proteins; D020738:Leptin; D052243:Resistin; C493572:Slc27a4 protein, mouse; D013549:Sweetening Agents; C003243:psicose; D005632:Fructose; D005947:Glucose
keywords: Fecal lipid excretion; Lipogenesis; d-allulose; β-oxidation