title: Role of platelets in cancer and cancer-associated thrombosis: Experimental and clinical evidences.
abstract: The primary hemostatic function of platelets has been recognized for more than a century, but increasing experimental and clinical evidences suggest that platelets are also important mediators of cancer. Cancer indeed influences platelet physiology, and activated platelets participate in each step of cancer development by promoting tumor growth, angiogenesis, metastasis, and cancer-associated thrombosis. Based on both the results of numerous experimental models addressing the involvement of platelets in cancer progression and the results of epidemiologic studies on the use of anti-platelet drugs to prevent cancer, platelets have been proposed as a potential target to reduce the short-term risk of cancer, cancer dissemination and cancer mortality. However, the cancer-associated thrombosis and the risk of bleeding due to anti-platelet drugs are not enough evaluated in experimental models. Therefore, the interesting contribution of platelets to cancer and cancer-associated thrombosis requires the standardization of preclinical and clinical models.
authors.affiliation: Aix-Marseille Université, INSERM UMR-S1076, Vascular Research Center of Marseille (VRCM), 27 Boulevard Jean Moulin, 13385 Marseille, France.
authors.forename: Soraya
authors.initials: S
authors.lastname: Mezouar
authors.affiliation: Aix-Marseille Université, INSERM UMR-S1076, Vascular Research Center of Marseille (VRCM), 27 Boulevard Jean Moulin, 13385 Marseille, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Frère
authors.affiliation: Aix-Marseille Université, INSERM UMR-S1076, Vascular Research Center of Marseille (VRCM), 27 Boulevard Jean Moulin, 13385 Marseille, France.
authors.forename: Roxane
authors.initials: R
authors.lastname: Darbousset
authors.affiliation: Aix-Marseille Université, INSERM UMR-S1076, Vascular Research Center of Marseille (VRCM), 27 Boulevard Jean Moulin, 13385 Marseille, France.
authors.forename: Diane
authors.initials: D
authors.lastname: Mege
authors.affiliation: Aix-Marseille Université, INSERM UMR-S1076, Vascular Research Center of Marseille (VRCM), 27 Boulevard Jean Moulin, 13385 Marseille, France.
authors.forename: Lydie
authors.initials: L
authors.lastname: Crescence
authors.affiliation: Aix-Marseille Université, INSERM UMR-S1076, Vascular Research Center of Marseille (VRCM), 27 Boulevard Jean Moulin, 13385 Marseille, France; Laboratoire d'Hématologie, Centre Hospitalo-Universitaire Conception, 385 Boulevard Baille, 13385 Marseille, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Dignat-George
authors.affiliation: Aix-Marseille Université, INSERM UMR-S1076, Vascular Research Center of Marseille (VRCM), 27 Boulevard Jean Moulin, 13385 Marseille, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Panicot-Dubois
authors.affiliation: Aix-Marseille Université, INSERM UMR-S1076, Vascular Research Center of Marseille (VRCM), 27 Boulevard Jean Moulin, 13385 Marseille, France. Electronic address: christophe.dubois@univ-amu.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Dubois
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000473:pathology*; D006801:Humans; D009369:Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology; D015539:Platelet Activation; D013927:Thrombosis / Q000097:blood / Q000209:etiology* / Q000473:pathology
keywords: Cancer; Clinical investigations; Experimental models; Immunothrombosis; Platelet