title: Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients.
abstract: OBJECTIVE
  The aim of this study was to investigate factors associated with thrombosis that may contribute to recurrent pregnancy loss (habitual abortion), specifically differences in serum levels of platelet-activating factor and thrombin-activatable fibrinolysis inhibitor (carboxypeptidase B2) between women with a history of recurrent miscarriage and those with no recurrent miscarriage history.
  
  
  METHODS
  A case-controlled, prospective study design was adopted to compare women with a history of two or more first-trimester miscarriages (n = 42) with those with no history of recurrent miscarriage (n = 36). Participants were recruited from the Department of Obstetrics and Gynecology of Turgut Ozal University Hospital. Platelet-activating factor and thrombin-activatable fibrinolysis inhibitor levels in serum samples were measured by an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Platelet-activating factor levels were significantly (p = 0.018) higher in the recurrent miscarriage group. There was no difference in levels of thrombin-activatable fibrinolysis inhibitor expression between the groups.
  
  
  CONCLUSIONS
  Platelet-activating factor is significantly higher in serum of patients with a history of recurrent miscarriage than in those without such a history, with potential implications for placental function and fetal growth, which could be relevant to miscarriage recurrence. Larger studies are indicated to further examine these findings.
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Ozal University Medical School, Ankara, Turkey. Electronic address: aylaacar76@yahoo.com.tr.
authors.forename: Ayla
authors.initials: A
authors.lastname: Eser
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Ozal University Medical School, Ankara, Turkey.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Inegol Gumus
authors.affiliation: Department of Biochemistry, Turgut Ozal University Medical School, Ankara, Turkey.
authors.forename: Husamettin
authors.initials: H
authors.lastname: Erdamar
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Ozal University Medical School, Ankara, Turkey.
authors.forename: Ikbal
authors.initials: I
authors.lastname: Kaygusuz
authors.affiliation: Department of Obstetrics and Gynecology, Ataturk Education and Research Hospital, Ankara, Turkey.
authors.forename: Melahat
authors.initials: M
authors.lastname: Yildirim
authors.affiliation: Department of Obstetrics and Gynecology, Cengiz Gokcek Hospital, Gaziantep, Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Usluogullari
authors.affiliation: Department of Obstetrics and Gynecology, Sevket Yilmaz Education and Research Hospital, Bursa, Turkey.
authors.forename: Muzeyyen
authors.initials: M
authors.lastname: Duran Erdolu
authors.affiliation: Department of Obstetrics and Gynecology, Pamukkale University Medical School, Denizli, Turkey.
authors.forename: Serap Aynur
authors.initials: SA
authors.lastname: Simavli
authors.affiliation: Department of Biochemistry, Turgut Ozal University Medical School, Ankara, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Yigitoglu
authors.affiliation: Department of Obstetrics and Gynecology, Sitki Kocman University Medical School, Mugla, Turkey.
authors.forename: Nilgun
authors.initials: N
authors.lastname: Ozturk Turhan
mesh_terms: D000026:Abortion, Habitual / Q000097:blood*; D000328:Adult; D025901:Carboxypeptidase B2 / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D010972:Platelet Activating Factor / Q000378:metabolism*; D011446:Prospective Studies
chemical_list: D010972:Platelet Activating Factor; C585364:CPB2 protein, human; D025901:Carboxypeptidase B2
keywords: abortion; carboxypeptidase B2; habitual; platelet activating factor; pregnancy