title: Ampicillin in Combination with Ceftaroline, Cefepime, or Ceftriaxone Demonstrates Equivalent Activities in a High-Inoculum Enterococcus faecalis Infection Model.
abstract: Ampicillin-ceftriaxone combination therapy has become a predominant treatment for serious Enterococcus faecalis infections, such as endocarditis. Unfortunately, ceftriaxone use is associated with future vancomycin-resistant enterococcus colonization. We evaluated E. faecalis in an in vitro pharmacodynamic model against simulated human concentration-time profiles of ampicillin plus ceftaroline, cefepime, ceftriaxone, or gentamicin. Ampicillin-cefepime and ampicillin-ceftaroline demonstrated activities similar to those of ampicillin-ceftriaxone against E. faecalis.
authors.affiliation: Department of Pharmacy Practice, University of Rhode Island, Kingston, Rhode Island, USA Rhode Island Infectious Diseases (RIID) Research Program, Veterans Affairs Medical Center, Providence, Rhode Island, USA.
authors.forename: Megan K
authors.initials: MK
authors.lastname: Luther
authors.affiliation: Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA Rhode Island Hospital, Providence, Rhode Island, USA.
authors.forename: Louis B
authors.initials: LB
authors.lastname: Rice
authors.affiliation: Department of Pharmacy Practice, University of Rhode Island, Kingston, Rhode Island, USA Rhode Island Infectious Diseases (RIID) Research Program, Veterans Affairs Medical Center, Providence, Rhode Island, USA Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA kerrylaplante@uri.edu.
authors.forename: Kerry L
authors.initials: KL
authors.lastname: LaPlante
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000077723:Cefepime; D002443:Ceftriaxone / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects*; D005839:Gentamicins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D000097583:Ceftaroline
chemical_list: D000667:Ampicillin; D000900:Anti-Bacterial Agents; D000077723:Cefepime; D002443:Ceftriaxone; D002511:Cephalosporins; D005839:Gentamicins; D000097583:Ceftaroline