title: Evolving Evidence of the Efficacy and Safety of nab-Paclitaxel in the Treatment of Cancers with Squamous Histologies.
abstract: Taxanes, such as paclitaxel and docetaxel, are well-established cytotoxic chemotherapeutics used in the treatment of a variety of cancers, including those of squamous histology. In their formulation, both agents require solvents, which have been associated with hypersensitivity reactions, peripheral neuropathy, hepatic toxicities, and impaired drug delivery. nab-Paclitaxel is a novel, albumin-bound form of paclitaxel with improved tolerability, bioavailability, and efficacy compared with solvent-based paclitaxel. Currently, nab-paclitaxel is approved for the treatment of metastatic breast cancer, locally advanced/metastatic non-small cell lung cancer (NSCLC), and metastatic pancreatic cancer. Clinical studies suggest that nab-paclitaxel may be particularly effective in cancers with squamous histology, including NSCLC. This article reviews the emerging evidence supporting nab-paclitaxel as an effective agent in the treatment of malignancies of squamous histology.
authors.affiliation: 1. Department of Clinical Oncology, State Key Laboratory in Oncology in South China, Hong Kong Cancer Institute, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, NT, Hong Kong SAR; 2. Department of Clinical Oncology, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, NT, Hong Kong SAR.
authors.forename: Herbert H
authors.initials: HH
authors.lastname: Loong
authors.affiliation: 2. Department of Clinical Oncology, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, NT, Hong Kong SAR.
authors.forename: Alvita C Y
authors.initials: AC
authors.lastname: Chan
authors.affiliation: 2. Department of Clinical Oncology, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, NT, Hong Kong SAR.
authors.forename: Ashley C Y
authors.initials: AC
authors.lastname: Wong
keywords: esophageal cancer; head/neck cancer; nab-paclitaxel; nasopharyngeal carcinoma; non-small cell lung cancer (NSCLC); squamous cell carcinoma