title: Successful Preoperative Chemoembolization in the Treatment of a Giant Malignant Phyllodes Tumor.
abstract: The malignant phyllodes tumor is a relatively rare neoplasm and has not previously been a therapeutic target of interventional radiology. Herein, we report a successful case of preoperative chemoembolization of a giant malignant phyllodes tumor. The objective was to achieve sufficient tumor shrinkage before surgery to avoid the requirement for skin grafting after resection. Intra-arterial epirubicin infusion and subsequent embolization with Embosphere Microspheres (BioSphere Medical, Rockland, MA, USA) was undertaken three times over the course of 6 weeks and was well tolerated. The patient underwent surgery without skin grafting. Neither local recurrence nor distant metastasis was observed at 6 months after surgery.
authors.affiliation: Department of Radiology, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki, 216-8511, Japan. kazkik1980@gmail.com.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Hashimoto
authors.affiliation: Department of Radiology, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki, 216-8511, Japan.
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Mimura
authors.affiliation: Department of Radiology, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki, 216-8511, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Arai
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki, 216-8511, Japan.
authors.forename: Masatomo
authors.initials: M
authors.lastname: Doi
authors.affiliation: Division of Breast and Endocrine Surgery, Department of Surgery, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki, 216-8511, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kojima
authors.affiliation: Division of Breast and Endocrine Surgery, Department of Surgery, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki, 216-8511, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tsugawa
authors.affiliation: Department of Radiology, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki, 216-8511, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008408:Mastectomy; D064847:Multimodal Imaging; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D003557:Phyllodes Tumor / Q000000981:diagnostic imaging / Q000628:therapy*
chemical_list: D015251:Epirubicin
keywords: Embosphere Microspheres; Epirubicin; Intra-arterial chemoembolization; Malignant phyllodes tumor; Neoadjuvant chemotherapy; Preoperative chemoembolization