title: Implications of Lymphatic Transport to Lymph Nodes in Immunity and Immunotherapy.
abstract: Adaptive immune response consists of many highly regulated, multistep cascades that protect against infection while preserving the health of autologous tissue. The proper initiation, maintenance, and resolution of such responses require the precise coordination of molecular and cellular signaling over multiple time and length scales orchestrated by lymphatic transport. In order to investigate these functions and manipulate them for therapy, a comprehensive understanding of how lymphatics influence immune physiology is needed. This review presents the current mechanistic understanding of the role of the lymphatic vasculature in regulating biomolecule and cellular transport from the interstitium, peripheral tissue immune surveillance, the lymph node stroma and microvasculature, and circulating lymphocyte homing to lymph nodes. This review also discusses the ramifications of lymphatic transport in immunity as well as tolerance and concludes with examples of how lymphatic-mediated targeting of lymph nodes has been exploited for immunotherapy applications.
authors.affiliation: George W. Woodruff School of Mechanical Engineering and.|Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332; email: susan.thomas@gatech.edu.|Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332.|Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322.
authors.forename: Susan N
authors.initials: SN
authors.lastname: Thomas
authors.affiliation: George W. Woodruff School of Mechanical Engineering and.|Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332; email: susan.thomas@gatech.edu.
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Rohner
authors.affiliation: Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332; email: susan.thomas@gatech.edu.|Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Edwards
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007167:Immunotherapy / Q000379:methods*; D008198:Lymph Nodes / Q000276:immunology*; D042601:Lymphatic Vessels / Q000276:immunology*; D018448:Models, Immunological
keywords: adaptive immune response; immune physiology; immune tolerance