title: IMAGE-GUIDED TREATMENT USING AN X-RAY THERAPY UNIT AND GOLD NANOPARTICLES: TEST OF CONCEPT.
abstract: Gold nanoparticles (GNPs) have the potential to enhance the radiation dose locally in conjunction with kV X-rays used for radiation therapy. As for other radiotherapy modalities, the absorbed dose needs to be controlled. To do that, it is an advantage to know the distribution of GNPs. However, no effective imaging tool exists to determine the GNP distribution in vivo. Various approaches have been proposed to determine the concentration of GNPs and its distribution in a tumour and in other organs and tissues. X-ray fluorescence computed tomography (XFCT) is a promising imaging technique to do that. A new experimental device based on the XFCT technique allowing the in vivo control of GNP radiotherapy treatments is proposed. As a test of concept, experimental acquisitions and Monte Carlo simulations were performed to determine the performance that a XFCT detector has to fulfil.
authors.affiliation: CEA, LIST, F-91191 Gif-sur-Yvette, France cindy.le-loirec@cea.fr.
authors.forename: Cindy
authors.initials: C
authors.lastname: Le Loirec
authors.affiliation: CEA, LIST, F-91191 Gif-sur-Yvette, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Chambellan
authors.affiliation: CEA, LIST, F-91191 Gif-sur-Yvette, France.
authors.forename: David
authors.initials: D
authors.lastname: Tisseur
mesh_terms: D003287:Contrast Media / Q000627:therapeutic use; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006046:Gold / Q000627:therapeutic use*; D006801:Humans; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D019047:Phantoms, Imaging; D010865:Pilot Projects; D011835:Radiation Protection / Q000295:instrumentation; D011856:Radiographic Image Enhancement / Q000295:instrumentation*; D061089:Radiotherapy, Image-Guided / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D000068936:Theranostic Nanomedicine / Q000379:methods
chemical_list: D003287:Contrast Media; D006046:Gold