title: Systemic Juvenile Idiopathic Arthritis: Diagnosis and Management.
abstract: Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory condition characterized by fever, lymphadenopathy, arthritis, rash and serositis. In sJIA, systemic inflammation has been associated with dysregulation of the innate immune system, suggesting that it is an autoinflammatory disorder. IL-1 and IL-6 play a major role in the pathogenesis of sJIA and treatment with IL-1 and IL-6 inhibitors has shown to be highly effective. Recent data suggests that early cytokine blockage might abrogate chronic, destructive, therapy resistant arthritis phase, reflecting a potential "window of opportunity" in the care of children with sJIA.
authors.affiliation: Department of Pediatrics, Christian Medical College, Vellore, Tamil Nadu, 632004, India. sathishkumar_cmc@yahoo.com.
authors.forename: Sathish
authors.initials: S
authors.lastname: Kumar
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D002648:Child; D016207:Cytokines / Q000187:drug effects / Q000276:immunology*; D019468:Disease Management; D006801:Humans
chemical_list: D018501:Antirheumatic Agents; D016207:Cytokines
keywords: Interleukin-1 blockade; Systemic JIA; Treatment