title: Systemic lupus erythematosus: Is it one disease?
abstract: Systemic lupus erythematosus (SLE) is a multisystemic disease with a variety of clinical presentations. Monogenic predisposing conditions to the development of this disease have been described. As examples, an impaired expression of interferon-α regulated genes or complement deficiencies have been reported in patients with SLE, with particular clinical presentations. Those defects present particular presentations and a different severity, making an argument that lupus is not a single disease but many. Treatment could be individualized depending on the underlying defect generating the subtype of the disease.
authors.affiliation: Servicio de Inmunología Clínica, Instituto Nacional de Pediatría Insurgentes Sur, México D.F., México.
authors.forename: Francisco
authors.initials: F
authors.lastname: Rivas-Larrauri
authors.affiliation: Servicio de Inmunología Clínica, Instituto Nacional de Pediatría Insurgentes Sur, México D.F., México. Electronic address: yzki71@yahoo.com.mx.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Yamazaki-Nakashimada
mesh_terms: D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D010641:Phenotype; D057285:Precision Medicine; D012720:Severity of Illness Index
chemical_list: D005819:Genetic Markers
keywords: Complement deficiency; Deficiencia de complemento; Inmunodeficiencia primaria; Interferonopathy; Interferonopatía; Lupus eritematoso sistémico; Primary immunodeficiency; Systemic lupus erythematosus