title: Role of the reprogramming factor KLF4 in blood formation.
abstract: Krüppel-like factor 4 is a zinc finger protein with dual functions that can act as a transcriptional activator and repressor of genes involved in cell proliferation, differentiation, and apoptosis. Although most studies have focused on terminally differentiated epithelial cells, evidence suggests that Krüppel-like factor 4 regulates the development and function of the myeloid and lymphoid blood lineages. The ability of Krüppel-like factor 4 to dedifferentiate from somatic cells into pluripotent stem cells in cooperation with other reprogramming factors suggests its potential function in the preservation of tissue-specific stem cells. Additionally, emerging interest in the redifferentiation of induced pluripotent stem cells into blood cells to correct hematologic deficiencies and malignancies warrants further studies on the role of Krüppel-like factor 4 in steady-state blood formation.
authors.affiliation: Department of Pathology & Immunology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA; and.
authors.forename: Chun Shik
authors.initials: CS
authors.lastname: Park
authors.affiliation: Department of Pathology & Immunology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA; and.
authors.forename: Ye
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Pathology & Immunology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA; and.
authors.forename: Andrew
authors.initials: A
authors.lastname: Lewis
authors.affiliation: Department of Pathology & Immunology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA; and Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA hdl@bcm.edu.
authors.forename: H Daniel
authors.initials: HD
authors.lastname: Lacorazza
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming / Q000235:genetics; D002843:Chromatin / Q000378:metabolism; D005786:Gene Expression Regulation; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D002843:Chromatin; C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors
keywords: gene regulation; hematopoiesis; lymphocytes; myeloid cells; transcription factor