title: Cytokine Responses in Gills of Capoeta umbla as Biomarkers of Environmental Pollution.
abstract: Immunological biomarkers reflect the effects of exposure to environmental contaminants. In this study, the suitability and sensitivity of cytokine responses, interleukin1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) in gill tissues of Capoeta umbla (Heckel, 1843), collected from different regions, as early warning indices of environmental pollution and ecosystem health was evaluated. Fish and water samples were taken from ten stations in March and September 2011 and 2012. Tumor necrosis factor-α, IL-1β and IL-6 levels were determined in samples of the gill tissues by using an ELISA kit. Significant variations of TNF-α, IL-1β and IL-6 levels observed between stations and seasons. The results of this study show that seasonal variations of cytokine responses in gills of Capoeta umbla are sensitive to the contaminants present in Uzuncayir Dam Lake (Tunceli, Turkey) water and are valuable biomarkers for environmental pollution and ecosystem health.
authors.affiliation: Tunceli University, Fisheries Faculty, TR62000, Tunceli, Turkey.
authors.forename: Durali
authors.initials: D
authors.lastname: Danabas
authors.forename: Nuran Cikcikoglu
authors.initials: NC
authors.lastname: Yildirim
authors.forename: Numan
authors.initials: N
authors.lastname: Yildirim
authors.forename: Ayten Oztufekci
authors.initials: AO
authors.lastname: Onal
authors.forename: Gulsad
authors.initials: G
authors.lastname: Uslu
authors.forename: Erhan
authors.initials: E
authors.lastname: Unlu
authors.forename: Seval
authors.initials: S
authors.lastname: Danabas
authors.forename: Cemil
authors.initials: C
authors.lastname: Ergin
authors.forename: Nilgun
authors.initials: N
authors.lastname: Tayhan
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D003530:Cyprinidae / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D004784:Environmental Monitoring / Q000379:methods*; D005880:Gills / Q000378:metabolism*; D060106:Lakes; D014421:Turkey
chemical_list: D015415:Biomarkers; D016207:Cytokines