title: Rheumatoid arthritis and associated large granular lymphocytic leukemia--successful treatment with rituximab.
abstract: Large granular lymphocytic (LGL) leukemia is an uncommon, usually indolent, lymphoproliferative disorder strongly associated with various autoimmune diseases. The authors report a case of a 67-year-old woman with a long-standing rheumatoid arthritis, who developed neutropenia and associated recurrent infections, diagnosed with LGL leukemia. We describe the treatment approach and the response to an anti-TNF and the rituximab.
authors.forename: A
authors.initials: A
authors.lastname: Raposo
authors.forename: M
authors.initials: M
authors.lastname: Cerqueira
authors.forename: J
authors.initials: J
authors.lastname: Costa
authors.forename: J
authors.initials: J
authors.lastname: Sousa Neves
authors.forename: F
authors.initials: F
authors.lastname: Teixeira
authors.forename: C
authors.initials: C
authors.lastname: Afonso
mesh_terms: D000368:Aged; D000074322:Antineoplastic Agents, Immunological / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D000068800:Etanercept / Q000627:therapeutic use; D005260:Female; D006801:Humans; D054066:Leukemia, Large Granular Lymphocytic / Q000150:complications / Q000188:drug therapy*; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology; D012008:Recurrence; D000069283:Rituximab / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000074322:Antineoplastic Agents, Immunological; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D000069283:Rituximab; D000068800:Etanercept