title: Critical analysis of protein signaling networks involved in the regulation of plant secondary metabolism: focus on anthocyanins.
abstract: Anthocyanin biosynthesis in Arabidopsis is a convenient and relatively simple model for investigating the basic principles of secondary metabolism regulation. In recent years, many publications have described links between anthocyanin biosynthesis and general defense reactions in plants as well as photomorphogenesis and hormonal signaling. These relationships are complex, and they cannot be understood intuitively. Upon observing the lacuna in the Arabidopsis interactome (an interaction map of the factors involved in the regulation of Arabidopsis secondary metabolism is not available), we attempted to connect various cellular processes that affect anthocyanin biosynthesis. In this review, we revealed the main signaling protein modules that regulate anthocyanin biosynthesis. To our knowledge, this is the first reconstruction of a network of proteins involved in plant secondary metabolism.
authors.affiliation: a Institute of Biology and Soil Science, Far East Branch of the Russian Academy of Sciences , Vladivostok 690022 , Russia and.|b Far Eastern Federal University , Vladivostok 690950 , Russia , and.
authors.forename: Victor P
authors.initials: VP
authors.lastname: Bulgakov
authors.affiliation: a Institute of Biology and Soil Science, Far East Branch of the Russian Academy of Sciences , Vladivostok 690022 , Russia and.
authors.forename: Tatiana V
authors.initials: TV
authors.lastname: Avramenko
authors.affiliation: c Institute of Applied Mathematics, Far East Branch of the Russian Academy of Sciences.
authors.forename: Gurami Sh
authors.initials: GS
authors.lastname: Tsitsiashvili
mesh_terms: D000872:Anthocyanins / Q000378:metabolism*; D017360:Arabidopsis; D029681:Arabidopsis Proteins; D018506:Gene Expression Regulation, Plant; D064210:Secondary Metabolism; D014157:Transcription Factors
chemical_list: D000872:Anthocyanins; D029681:Arabidopsis Proteins; D014157:Transcription Factors
keywords: Anthocyanins; Arabidopsis thaliana; interactome; protein networks; secondary metabolism