title: New cytotoxic neo-clerodane diterpenoids from Scutellaria strigillosa.
abstract: Three new neo-clerodane diterpenoids, named scutestrigillosins A-C (1-3), were isolated from the whole plant of Scutellaria strigillosa. Their chemical structures including absolute configurations were established on the basis of detailed physical data analyses. In vitro, the isolated three new compounds exhibited significant cytotoxic activities against four tumor cell lines (HONE-1, P-388, MCF7 and HT29), and gave IC50 values in the range 3.5-7.7μM.
authors.affiliation: School of Pharmaceutical Science, Yantai University, Yantai 264005, PR China. Electronic address: daishengjun_9@hotmail.com.
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Dai
authors.affiliation: School of Pharmaceutical Science, Yantai University, Yantai 264005, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Science, Yantai University, Yantai 264005, PR China.
authors.forename: Kai
authors.initials: K
authors.lastname: Xiao
authors.affiliation: School of Pharmaceutical Science, Yantai University, Yantai 264005, PR China.
authors.forename: Qing-Tong
authors.initials: QT
authors.lastname: Han
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D031363:Scutellaria / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane
keywords: Cytotoxic activity; Scutellaria strigillosa; Scutestrigillosins A–C; neo-Clerodane diterpenoid