title: [Cytogenetic Abnormalities and Outcomes of 117 Patients with Multiple Myeloma Detected by FISH].
abstract: OBJECTIVE
  To analyze the cytogenetic abnormalities and prognostic outcomes of patients with multiple myeloma (MM) detected by fluorescence in situ hybridization (FISH).
  
  
  METHODS
  The clinical record of 117 newly-diagnosed patients with MM treated in department of hematology and geriatric hematology of our hospital for 7 years were collected, and their molecular cytogenetic abnormalities detected by FISH and the clinical outcome were analyzed retrospectively.
  
  
  RESULTS
  The detected rate of cytogenetic abnormality was 76.9%(90/117), the most common abnormality deteted by FISH was 1q21+ (71.1%), followed by 13q- (56.6%). The cross comparison method showed that 13q- and 17p13-, t(11;14) and t(4;14) were related respectively. All the patients with cytogenetic abnormalities showed no significant difference in the overall survival from cytogenetic normal patients.
  
  
  CONCLUSIONS
  The positive rate of molecular cytogenetic abnormalities detected by FISH in MM patients is high, but data from larger and longer studies are needed to evaluate the prognostic outcomes.
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.|Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhai
authors.affiliation: Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Zou
authors.affiliation: Department of Cardiology, Tianjin Chest Hospital, Tianjin 300222, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Yan
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Wang
authors.affiliation: Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Zhu
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Wen-Rong
authors.initials: WR
authors.lastname: Huang
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China. E-mail: liyu301@vip.163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Yu
mesh_terms: D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D003582:Cytogenetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009101:Multiple Myeloma / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D012189:Retrospective Studies; D014178:Translocation, Genetic