title: Prevalence of impaired odor identification in Parkinson disease with imaging evidence of nigrostriatal denervation.
abstract: There is wide variability in the reported prevalence rates of abnormal smell in Parkinson disease (PD). This study assessed the prevalence of abnormal smell, using the University of Pennsylvania Smell Identification Test (UPSIT), in 183 patients with PD with confirmed PET imaging evidence of nigrostriatal denervation. Impaired olfaction in this sample was nearly universal (97.8 %). Wide-ranging prior olfactory impairment estimates may reflect not only uncertainty regarding diagnostic classification, but also the use of inaccurate normative data and differences in olfactory tests used.
authors.affiliation: Functional Neuroimaging, Cognitive and Mobility Laboratory, Department of Radiology, University of Michigan, 24 Frank Lloyd Wright Drive, Box 362, Ann Arbor, MI, 48105-9755, USA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Haugen
authors.affiliation: Functional Neuroimaging, Cognitive and Mobility Laboratory, Department of Radiology, University of Michigan, 24 Frank Lloyd Wright Drive, Box 362, Ann Arbor, MI, 48105-9755, USA.|University of Michigan Morris K. Udall Center of Excellence for Parkinson's Disease Research, Ann Arbor, MI, USA.
authors.forename: Martijn L T M
authors.initials: ML
authors.lastname: Müller
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor, MI, USA.|Neurology Service and GRECC, VAAAHS, Ann Arbor, MI, USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Kotagal
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor, MI, USA.|University of Michigan Morris K. Udall Center of Excellence for Parkinson's Disease Research, Ann Arbor, MI, USA.|Neurology Service and GRECC, VAAAHS, Ann Arbor, MI, USA.
authors.forename: Roger L
authors.initials: RL
authors.lastname: Albin
authors.affiliation: Functional Neuroimaging, Cognitive and Mobility Laboratory, Department of Radiology, University of Michigan, 24 Frank Lloyd Wright Drive, Box 362, Ann Arbor, MI, 48105-9755, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Koeppe
authors.affiliation: Functional Neuroimaging, Cognitive and Mobility Laboratory, Department of Radiology, University of Michigan, 24 Frank Lloyd Wright Drive, Box 362, Ann Arbor, MI, 48105-9755, USA.
authors.forename: Peter J H
authors.initials: PJ
authors.lastname: Scott
authors.affiliation: Functional Neuroimaging, Cognitive and Mobility Laboratory, Department of Radiology, University of Michigan, 24 Frank Lloyd Wright Drive, Box 362, Ann Arbor, MI, 48105-9755, USA.|Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Kirk A
authors.initials: KA
authors.lastname: Frey
authors.affiliation: Functional Neuroimaging, Cognitive and Mobility Laboratory, Department of Radiology, University of Michigan, 24 Frank Lloyd Wright Drive, Box 362, Ann Arbor, MI, 48105-9755, USA. nbohnen@umich.edu.|Department of Neurology, University of Michigan, Ann Arbor, MI, USA. nbohnen@umich.edu.|University of Michigan Morris K. Udall Center of Excellence for Parkinson's Disease Research, Ann Arbor, MI, USA. nbohnen@umich.edu.|Neurology Service and GRECC, VAAAHS, Ann Arbor, MI, USA. nbohnen@umich.edu.
authors.forename: Nicolaas I
authors.initials: NI
authors.lastname: Bohnen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000453:epidemiology* / Q000209:etiology; D010300:Parkinson Disease / Q000150:complications* / Q000473:pathology*; D049268:Positron-Emission Tomography; D015995:Prevalence; D013378:Substantia Nigra / Q000473:pathology*
keywords: Aging; Dopamine; Olfaction; PET; Parkinson disease