title: Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization.
abstract: Squamous cell carcinomas of the lung and of the head and neck district share strong association with smoking habits and are characterized by smoke-related genetic alterations. Driver mutations have been identified in small percentage of lung squamous cell carcinoma. In parallel, squamous head and neck tumors are classified according to the HPV positivity, thus identifying two different clinical and molecular subgroups of disease.This review depicts different molecular portraits and potential clinical application in the field of targeted therapy, immunotherapy and chemotherapy personalization.
authors.affiliation: Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.|Department of Surgery, Oncology and Gastroenterology, Università degli Studi di Padova, Padova, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Polo
authors.affiliation: Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Pasello
authors.affiliation: Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Frega
authors.affiliation: Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Favaretto
authors.affiliation: Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.
authors.forename: Haralabos
authors.initials: H
authors.lastname: Koussis
authors.affiliation: Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.|Department of Surgery, Oncology and Gastroenterology, Università degli Studi di Padova, Padova, Italy.
authors.forename: Pierfranco
authors.initials: P
authors.lastname: Conte
authors.affiliation: Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Bonanno
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications; D012907:Smoking / Q000009:adverse effects; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: HPV; head and neck; lung; smoke; squamous cell carcinoma