title: Preclinical animal models of multiple myeloma.
abstract: Multiple myeloma is an incurable plasma-cell malignancy characterized by osteolytic bone disease and immunosuppression. Murine models of multiple myeloma and myeloma bone disease are critical tools for an improved understanding of the pathogenesis of the disease and the development of novel therapeutic strategies. This review will cover commonly used immunocompetent and xenograft models of myeloma, describing the advantages and disadvantages of each model system. In addition, this review provides detailed protocols for establishing systemic and local models of myeloma using both murine and human myeloma cell lines.
authors.affiliation: Nuffield Department of Surgical Sciences, University of Oxford , Oxford, UK.
authors.forename: Seint T
authors.initials: ST
authors.lastname: Lwin
authors.affiliation: Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK.
authors.forename: Claire M
authors.initials: CM
authors.lastname: Edwards
authors.affiliation: Division of Hematology/Oncology, Indiana University School of Medicine , Indianapolis, IN, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Silbermann