title: TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk.
abstract: BACKGROUND
  This study is to investigate the association of fibroblast growth factor receptor 2 (FGFR2) rs2981582, trinucleotide-repeat-containing 9 (TNRC9) rs3803662, rs12443621, and leukocyte-specific protein 1 (LSP1) rs3817198 polymorphisms with breast cancer and mammographic density in Han Chinese population.
  
  
  METHODS
  TaqMan Single Nucleotide Polymorphism (SNP) Genotyping Assays and unconditional logistic regression analysis were used to examine these SNPs in 105 breast cancer cases and 382 controls.
  
  
  RESULTS
  The genotype frequencies of rs12443621 and rs2981582 were significantly different between controls and cases (P=0.017 and 0.006, respectively). Subjects carrying G allele of rs12443621 had increased breast cancer risk (AG vs AA: OR=2.017, 95% CI=0.910-4.471; GG vs AA: OR=2.684, 95% CI=1.318-5.463). Subjects carrying an allele of rs2981582 had reduced breast cancer risk (GA vs GG: OR=0.444, 95% CI=0.262-0.752; AA vs GG: OR=0.579, 95% CI=0.342-0.983). rs3803662 and rs3817198 SNPs did not significantly differ between cases and controls (P=0.408 and 0.116, respectively). Interestingly, the AA genotype of rs2981582 was also associated with reduced mammographic densities (P=0.0092, 95% CI=0.334-0.926).
  
  
  CONCLUSIONS
  Our findings indicate that the GG genotype of rs12443621 is associated with increased breast cancer risk whereas the GA and AA genotypes of rs2981582 are reduced risk in Han Chinese population.
authors.affiliation: Department of Radiology, Shengjing Hospital Affiliated to China Medical University, No. 36, Sanhao ST, Heping District, Shenyang, Liaoning Province, 110004, China. 13039993666@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Radiology, First Affiliated Hospital of Harbin Medical University, No. 23 Post ST, Nangang District, Harbin, Heilongjiang Province, 150081, China. happy_scy@163.com.
authors.forename: Chunying
authors.initials: C
authors.lastname: Shi
authors.affiliation: Department of Radiology, Shengjing Hospital Affiliated to China Medical University, No. 36, Sanhao ST, Heping District, Shenyang, Liaoning Province, 110004, China. chenyinghyd@sina.com.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Guo
mesh_terms: D051017:Apoptosis Regulatory Proteins; D014408:Biomarkers, Tumor / Q000235:genetics*; D000071060:Breast Density; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006609:High Mobility Group Proteins; D006801:Humans; D042361:Mammary Glands, Human / Q000002:abnormalities* / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics*; D011980:Receptors, Progesterone / Q000235:genetics*; D012307:Risk Factors; D015534:Trans-Activators
chemical_list: D051017:Apoptosis Regulatory Proteins; D014408:Biomarkers, Tumor; D006609:High Mobility Group Proteins; D011980:Receptors, Progesterone; C521752:TOX3 protein, human; D015534:Trans-Activators; C496353:FGFR2 protein, human; D051497:Receptor, Fibroblast Growth Factor, Type 2