title: Brown adipose tissue transplantation ameliorates polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS), which is characterized by anovulation, hyperandrogenism, and polycystic ovaries, is a complex endocrinopathy. Because the cause of PCOS at the molecular level is largely unknown, there is no cure or specific treatment for PCOS. Here, we show that transplantation of brown adipose tissue (BAT) reversed anovulation, hyperandrogenism, and polycystic ovaries in a dehydroepiandrosterone (DHEA)-induced PCOS rat. BAT transplantation into a PCOS rat significantly stabilized menstrual irregularity and improved systemic insulin sensitivity up to a normal level, which was not shown in a sham-operated or muscle-transplanted PCOS rat. Moreover, BAT transplantation, not sham operation or muscle transplantation, surprisingly improved fertility in PCOS rats. Interestingly, BAT transplantation activated endogenous BAT and thereby increased the circulating level of adiponectin, which plays a prominent role in whole-body energy metabolism and ovarian physiology. Consistent with BAT transplantation, administration of adiponectin protein dramatically rescued DHEA-induced PCOS phenotypes. These results highlight that endogenous BAT activity is closely related to the development of PCOS phenotypes and that BAT activation might be a promising therapeutic option for the treatment of PCOS.
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences, Beijing 100049, China;
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences, Beijing 100049, China;
authors.forename: Tao
authors.initials: T
authors.lastname: Hu
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China; The Key Laboratory for Reproductive Endocrinology of the Ministry of Education, Jinan, Shandong 250001, China;
authors.forename: Han
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences, Beijing 100049, China;
authors.forename: Rongcai
authors.initials: R
authors.lastname: Ye
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences, Beijing 100049, China;
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Nanjing Agriculture University, Nanjing 210095, China;
authors.forename: Chuanhai
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;
authors.forename: Hanlin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences, Beijing 100049, China;
authors.forename: Gang
authors.initials: G
authors.lastname: Wei
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences, Beijing 100049, China;
authors.forename: Huiqiao
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences, Beijing 100049, China;
authors.forename: Meng
authors.initials: M
authors.lastname: Dong
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China; The Key Laboratory for Reproductive Endocrinology of the Ministry of Education, Jinan, Shandong 250001, China;
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;
authors.forename: Haibin
authors.initials: H
authors.lastname: Wang
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui 230031, China;
authors.forename: Qingsong
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;
authors.forename: Hyuek Jong
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; jinw@ioz.ac.cn chenzijiang@hotmail.com.
authors.forename: Wanzhu
authors.initials: W
authors.lastname: Jin
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China; The Key Laboratory for Reproductive Endocrinology of the Ministry of Education, Jinan, Shandong 250001, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China jinw@ioz.ac.cn chenzijiang@hotmail.com.
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000494:pharmacology; D002001:Adipose Tissue, Brown / Q000637:transplantation*; D000328:Adult; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003687:Dehydroepiandrosterone; D004734:Energy Metabolism / Q000187:drug effects; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000601:surgery*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced / Q000378:metabolism / Q000601:surgery*; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D003687:Dehydroepiandrosterone
keywords: PCOS; adiponectin; ameliorates; brown adipose tissue; transplantation