title: Himalensines A and B, Alkaloids from Daphniphyllum himalense.
abstract: Chemical investigation into the alkaloidal constituents of the Nepalese Daphniphyllum himalense has returned two new compounds, himalensines A (1) and B (2), with unprecedented carbon skeletons. Structures of the two alkaloids have been characterized on the basis of spectroscopic methods, especially via 2D NMR data analysis. Himalensine B (2) showed marginal inhibitory activities against two kinases, PTP1B and IKK-β.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Nepal Academy of Science and Technology , Khumaltar, Lalitpur, G.P.O. Box 3323, Kathmandu 44700, Nepal.
authors.forename: Sajan L
authors.initials: SL
authors.lastname: Shyaula
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China.
authors.forename: Jing-Ya
authors.initials: JY
authors.lastname: Li
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000588:Amines / Q000737:chemistry; D064096:Aurora Kinase A / Q000037:antagonists & inhibitors; D002712:Chlorides / Q000737:chemistry; D003500:Cyclization; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases / Q000187:drug effects; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D031995:Saxifragaceae / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000588:Amines; D002712:Chlorides; D004365:Drugs, Chinese Herbal; D005290:Ferric Compounds; D011725:Pyridines; C000609059:himalensine A; C000609060:himalensine B; D064096:Aurora Kinase A; D051550:I-kappa B Kinase; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; C433811:HDAC6 protein, human; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases; C024555:ferric chloride