title: Ligand-Enabled Arylation of γ-C-H Bonds.
abstract: Pd(II) -catalyzed arylation of γ-C(sp(3) )-H bonds of aliphatic acid-derived amides was developed by using quinoline-based ligands. Various γ-aryl-α-amino acids were prepared from natural amino acids using this method. The influence of ligand structure on reactivity was also systematically investigated.
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
authors.forename: Suhua
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
authors.forename: Ru-Yi
authors.initials: RY
authors.lastname: Zhu
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
authors.forename: Kai-Jiong
authors.initials: KJ
authors.lastname: Xiao
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. yu200@scripps.edu.
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D008024:Ligands
chemical_list: D000596:Amino Acids; D008024:Ligands; D002244:Carbon; D006859:Hydrogen
keywords: arylation; carboxylic acids; palladium; quinoline ligand; γ-C-H activation