title: Layered MoS2 Hollow Spheres for Highly-Efficient Photothermal Therapy of Rabbit Liver Orthotopic Transplantation Tumors.
abstract: Combining photothermal therapy (PTT) with clinical technology to kill cancer via overcoming the low tumor targeting and poor therapy efficiency has great potential in basic and clinical researches. A brand-new MoS2 nanostructure is designed and fabricated, i.e., layered MoS2 hollow spheres (LMHSs) with strong absorption in near-infrared region (NIR) and high photothermal conversion efficiency via a simple and fast chemical aerosol flow method. Owing to curving layered hollow spherical structure, the as-prepared LMHSs exhibit unique electronic properties comparing with MoS2 nanosheets. In vitro and in vivo studies demonstrate their high photothermal ablation of cell and tumor elimination rate by single NIR light irradiation. Systematic acute toxicity study indicates that these LMHSs have negligible toxic effects to normal tissues and blood. Remarkably, minimally invasive interventional techniques are introduced to improve tumor targeting of PTT agents for the first time. To explore PTT efficiency on orthotopic transplantation tumors, New Zealand white rabbits with VX2 tumor in liver are used as animal models. The effective elimination of tumors is successfully realized by PTT under the guidance of digital subtraction angiography, computed tomography, and thermal imaging, which provides a new way for tumor-targeting delivery and cancer theranostic application.
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Longfei
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Materials Science and Engineering, Jinan University, Guangzhou, 510632, P. R. China.
authors.forename: Shengping
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Radiology First Hospital of China, Medical University, Shenyang, 110001, P. R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Tianlong
authors.initials: T
authors.lastname: Liu
authors.affiliation: Chinese PLA General Hospital, Beijing, 100853, P. R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
authors.affiliation: Department of Radiology First Hospital of China, Medical University, Shenyang, 110001, P. R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Niu
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Changhui
authors.initials: C
authors.lastname: Fu
authors.affiliation: Department of Radiology First Hospital of China, Medical University, Shenyang, 110001, P. R. China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Shao
authors.affiliation: Chinese PLA General Hospital, Beijing, 100853, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Radiology First Hospital of China, Medical University, Shenyang, 110001, P. R. China.
authors.forename: Tengchuang
authors.initials: T
authors.lastname: Ma
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Xiangling
authors.initials: X
authors.lastname: Ren
authors.affiliation: Department of Materials Science and Engineering, Jinan University, Guangzhou, 510632, P. R. China.|Engineering Research Center of Artificial Organs and Materials, Ministry of Education, Guangzhou, 510630, P R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: Chinese PLA General Hospital, Beijing, 100853, P. R. China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Dou
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Xianwei
authors.initials: X
authors.lastname: Meng
mesh_terms: D015901:Angiography, Digital Subtraction; D000818:Animals; D006979:Hyperthermia, Induced; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D016031:Liver Transplantation; D051379:Mice; D008982:Molybdenum / Q000737:chemistry*; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D009368:Neoplasm Transplantation; D010789:Phototherapy; D011817:Rabbits; D013056:Spectrophotometry, Ultraviolet; D019265:Spectroscopy, Near-Infrared; D014057:Tomography, X-Ray Computed
chemical_list: D008982:Molybdenum
keywords: cancer; hollow spheres; photothermal therapy; transarterial administration; transplantation tumors