title: Endothelin-1 concentrations are correlated with the severity of knee osteoarthritis.
abstract: Endothelin-1, a potent vasoconstrictor regulator, contributes to articular cartilage destruction. Therefore, we aim to assess the correlation of endothelin-1 concentrations with the development and severity of knee osteoarthritis (OA). This study included a population of 209 patients with knee OA. Kellgren-Lawrence (KL) grading was utilized to score the severity of OA. The case group had higher serum endothelin-1 concentrations than controls. Patients with knee OA with a relatively higher grade showed significantly elevated serum and synovial fluid (SF) endothelin-1 concentrations compared with those with lower KL grades. A significant correlation was found between serum and SF endothelin-1 concentrations and KL grades. Serum and SF endothelin-1 concentrations are correlated with the development and progression of knee OA.
authors.affiliation: Department of Surgery of Traditional Chinese Medicine, Tianjin Hospital, Tianjin, People's Republic of China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Orthopaedic Trauma, Tianjin Hospital, Tianjin, People's Republic of China.
authors.forename: Enqi
authors.initials: E
authors.lastname: Li
authors.affiliation: Department of Orthopaedic Trauma, Tianjin Hospital, Tianjin, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Cao
authors.affiliation: Department of Orthopaedic Trauma, Tianjin Hospital, Tianjin, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Orthopaedic Trauma, Tianjin Hospital, Tianjin, People's Republic of China.
authors.forename: Baotong
authors.initials: B
authors.lastname: Ma
mesh_terms: D016022:Case-Control Studies; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000473:pathology*; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000378:metabolism
chemical_list: D019332:Endothelin-1
keywords: Inflammation; Osteoarthritis