title: Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in an area of high endemicity in Republic of Korea.
abstract: Hantaan virus (HTNV), of the family Bunyaviridae, causes hemorrhagic fever with renal syndrome (HFRS) in humans. Although the majority of epidemiologic studies have found that rodents are seropositive for hantavirus-specific immunoglobulin, the discovery of hantavirus RNA in seronegative hosts has led to an investigation of the presence of HTNV RNA in rodents captured in HFRS endemic areas. HTNV RNA was detected in seven (3.8%) of 186 anti-HTNV IgG seronegative rodents in Republic of Korea (ROK) during 2013-2014. RT-qPCR for HTNV RNA revealed dynamic virus-host interactions of HTNV in areas of high endemicity, providing important insights into the epidemiology of hantaviruses.
authors.affiliation: Department of Microbiology, College of Medicine, Korea University, Seoul, 02841.
authors.forename: Jin Sun
authors.initials: JS
authors.lastname: No
authors.affiliation: Department of Microbiology, College of Medicine, Korea University, Seoul, 02841.
authors.forename: Won-Keun
authors.initials: WK
authors.lastname: Kim
authors.affiliation: Department of Microbiology, College of Medicine, Korea University, Seoul, 02841.
authors.forename: Jeong-Ah
authors.initials: JA
authors.lastname: Kim
authors.affiliation: Department of Microbiology, College of Medicine, Korea University, Seoul, 02841.
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Microbiology, College of Medicine, Korea University, Seoul, 02841.
authors.forename: Sook-Young
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Microbiology, College of Medicine, Korea University, Seoul, 02841.
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Microbiology, College of Medicine, Korea University, Seoul, 02841.
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Kho
authors.affiliation: Fifth Research and Development Institute, Agency of Defense Development, Yuseong P.O. Box 35, Daejeon, Korea, 34186.
authors.forename: Daesang
authors.initials: D
authors.lastname: Lee
authors.affiliation: Fifth Research and Development Institute, Agency of Defense Development, Yuseong P.O. Box 35, Daejeon, Korea, 34186.
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Song
authors.affiliation: Fifth Research and Development Institute, Agency of Defense Development, Yuseong P.O. Box 35, Daejeon, Korea, 34186.
authors.forename: Se Hun
authors.initials: SH
authors.lastname: Gu
authors.affiliation: Fifth Research and Development Institute, Agency of Defense Development, Yuseong P.O. Box 35, Daejeon, Korea, 34186.
authors.forename: Seong Tae
authors.initials: ST
authors.lastname: Jeong
authors.affiliation: Fifth Medical Detachment, 168th Multifunctional Medical Battalion, 65th Medical Brigade, Unit 15247, APO AP, 96205-5247.
authors.forename: Heung-Chul
authors.initials: HC
authors.lastname: Kim
authors.affiliation: Public Health Command District-Korea (Provisional), 65th Medical Brigade, Unit 15281, APO AP, 96205-5281, USA.
authors.forename: Terry A
authors.initials: TA
authors.lastname: Klein
authors.affiliation: Department of Microbiology, College of Medicine, Korea University, Seoul, 02841.
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Song
mesh_terms: D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D019353:Endemic Diseases; D018063:Hantaan virus / Q000235:genetics / Q000276:immunology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D012367:RNA, Viral / Q000235:genetics / Q000276:immunology*; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods; D056910:Republic of Korea / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D012367:RNA, Viral
keywords: Hantaan virus; epidemiology; virus-host interaction