title: Ubiquitin proteasome system research in gastrointestinal cancer.
abstract: The ubiquitin proteasome system (UPS) is important for the degradation of proteins in eukaryotic cells. It is involved in nearly every cellular process and plays an important role in maintaining body homeostasis. An increasing body of evidence has linked alterations in the UPS to gastrointestinal malignancies, including esophageal, gastric and colorectal cancers. Here, we summarize the current literature detailing the involvement of the UPS in gastrointestinal cancer, highlighting its role in tumor occurrence and development, providing information for therapeutic targets research and anti-gastrointestinal tumor drug design.
authors.affiliation: Jia-Ling Zhong, Clinical Laboratory Department, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China.
authors.forename: Jia-Ling
authors.initials: JL
authors.lastname: Zhong
authors.affiliation: Jia-Ling Zhong, Clinical Laboratory Department, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China.
authors.forename: Chang-Zhi
authors.initials: CZ
authors.lastname: Huang
keywords: Gastrointestinal cancer; Ubiquitin proteasome system