title: The Chemical Constituents and Bioactivities of Psoralea corylifolia Linn.: A Review.
abstract: Psoralea corylifolia Linn. (P. corylifolia) is an important medicinal plant with thousands of years of clinical application. It has been widely used in many traditional Chinese medicine formulas for the treatment of various diseases such as leucoderma and other skin diseases, cardiovascular diseases, nephritis, osteoporosis, and cancer. Phytochemical studies indicated that coumarins, flavonoids, and meroterpenes are the main components of P. corylifolia, and most of these components are present in the seeds or fruits. The extracts and active components of P. corylifolia demonstrated multiple biological activities, including estrogenic, antitumor, anti-oxidant, antimicrobial, antidepressant, anti-inflammatory, osteoblastic, and hepatoprotective activities. This paper systematically summarized literatures on the chemical constituents and biological activities of P. corylifolia, which provided useful information for the further research and development toward this potent medicinal plant.
authors.affiliation: * Department of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.|† State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
authors.forename: Xuenong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: † State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Zhao
authors.affiliation: † State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: † State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
authors.forename: Jinjian
authors.initials: J
authors.lastname: Lu
authors.affiliation: † State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
authors.forename: Xiuping
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000928:Antidepressive Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification; D004967:Estrogens; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008968:Molecular Conformation; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D029907:Psoralea / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000928:Antidepressive Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D003374:Coumarins; D004967:Estrogens; D005419:Flavonoids; D010936:Plant Extracts; D013729:Terpenes
keywords: Biological Activities; Chemical Constituents; Coumarins; Flavovoids; Meroterpenes; Psoralea corylifolia L.