title: Possibility of using salivary ultra-weak chemiluminescence as a biomarker for feelings of anxiety in hospital settings.
abstract: The aim of this study was to assess whether a particular value of noninvasive salivary ultra-weak chemiluminescence (UCL) could be used as a biomarker of psychological stress. Our study covered two groups. Group 1 comprised six healthy volunteers who stayed in a hospital for one night and group 2 comprised 15 patients with lung cancer and 24 patients with respiratory diseases other than lung cancer who were in hospital for an extended stay. First, we evaluated the UCL of saliva from six healthy volunteers before and after one night in hospital. Immunoglobulin A (IgA) concentrations were also measured. The integrated intensity value of UCL was correlated with the IgA concentration (correlation coefficient 0.90). Second, in the case of a long hospital stay, we found that the maximum salivary UCL intensities were higher in patients with lung cancer than in those with respiratory diseases other than lung cancer or in 28 healthy controls. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Japan. hiramatu@crl.hpk.co.jp.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Hiramatsu
authors.affiliation: Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.|Department of Internal Medicine, Hamamatsu Toyooka Hospital, Hamamatsu, Japan.
authors.forename: Kingo
authors.initials: K
authors.lastname: Chida
authors.affiliation: Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.|Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
authors.forename: Dai
authors.initials: D
authors.lastname: Hashimoto
authors.affiliation: Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Japan.
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Takamoto
authors.affiliation: Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Japan.
authors.forename: Katsu
authors.initials: K
authors.lastname: Honzawa
authors.affiliation: Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.affiliation: Electron Tube Division, Hamamatsu Photonics K.K., Iwata, Japan.
authors.forename: Kimitsugu
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Department of Environmental Biochemistry, University of Shizuoka, Shizuoka, Japan.|Department of Medical Technology, Azabu University, Sagamihara, Japan.
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Takagi
mesh_terms: D000328:Adult; D001007:Anxiety / Q000175:diagnosis* / Q000209:etiology*; D015415:Biomarkers / Q000737:chemistry*; D005260:Female; D006801:Humans; D007902:Length of Stay; D049449:Luminescence; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012140:Respiratory Tract Diseases / Q000150:complications*; D012463:Saliva / Q000737:chemistry*
chemical_list: D015415:Biomarkers
keywords: anxiety; hospital stay; immunoglobulin A (IgA); saliva; ultra-weak chemiluminescence (UCL)