title: Anisotropic Self-Assembly of Citrate-Coated Gold Nanoparticles on Fluidic Liposomes.
abstract: The behavior of self-assembly processes of nanoscale particles on plasma membranes can reveal mechanisms of important biofunctions and/or intractable diseases. Self-assembly of citrate-coated gold nanoparticles (cAuNPs) on liposomes was investigated. The adsorbed cAuNPs were initially fixed on the liposome surfaces and did not self-assemble below the phospholipid phase transition temperature (Tm ). In contrast, anisotropic cAuNP self-assembly was observed upon heating of the composite above the Tm, where the phospholipids became fluid. The number of self-assembled NPs is conveniently controlled by the initial mixing ratio of cAuNPs and liposomes. Gold nanoparticle protecting agents strongly affected the self-assembly process on the fluidic membrane.
authors.affiliation: Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima, 739-8527, Japan.
authors.forename: Kouta
authors.initials: K
authors.lastname: Sugikawa
authors.affiliation: Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima, 739-8527, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kadota
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, 630-0192, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Yasuhara
authors.affiliation: Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima, 739-8527, Japan. aikeda@hiroshima-u.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ikeda
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D019343:Citric Acid / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D008081:Liposomes; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D013056:Spectrophotometry, Ultraviolet
chemical_list: D008081:Liposomes; D015060:1,2-Dipalmitoylphosphatidylcholine; D019343:Citric Acid; D006046:Gold
keywords: gold nanoparticles; lipid bilayer; liposomes; phase transition temperature; self-assembly