title: α-Tocopherol in breast milk of women with preterm delivery after a single postpartum oral dose of vitamin E.
abstract: We evaluated the effect of maternal vitamin E supplementation on the α-tocopherol concentrations of colostrum, transitional milk and mature milk of women who had given birth prematurely. This longitudinal randomised-controlled trial divided eighty-nine women into two groups: a control group and a supplemented group. Blood and breast milk were collected from all the participants after delivery. Next, each woman in the supplemented group received 400 IU of RRR-α-tocopheryl acetate. Further breast milk samples were collected 24 h after the first collection, as well as 7 and 30 d after delivery. α-Tocopherol concentrations were determined by HPLC. The baseline α-tocopherol concentrations in the maternal serum of the two groups were similar: 1159·8 (sd 292·4) μg/dl (27·0 (SD 6·8) μmol/l) for the control group and 1128·3 (sd 407·2) μg/dl (26·2 (SD 9·5) μmol/l) for the supplemented group. None of the women was vitamin E deficient. Breast milk α-tocopherol concentrations increased by 60 % 24 h after supplementation in the intervention group and did not increase at all in the control group. α-Tocopherol concentration of the transitional milk in the supplemented group was 35 % higher compared with the control group. α-Tocopherol concentrations of the mature milk in both groups were similar. Maternal supplementation with 400 IU of RRR-α-tocopherol increased the vitamin E concentrations of the colostrum and transitional milk, but not of the mature milk. This study presents relevant information for the design of strategies to prevent and combat vitamin E deficiency in the risk group of preterm infants.
authors.affiliation: 1Department of Biochemistry,Federal University of Rio Grande do Norte,Ave. Senador Salgado Filho 3000,Lagoa Nova,Natal,59072-970,Brazil.
authors.forename: Jeane Franco
authors.initials: JF
authors.lastname: Pires Medeiros
authors.affiliation: 1Department of Biochemistry,Federal University of Rio Grande do Norte,Ave. Senador Salgado Filho 3000,Lagoa Nova,Natal,59072-970,Brazil.
authors.forename: Karla Danielly da Silva
authors.initials: KD
authors.lastname: Ribeiro
authors.affiliation: 1Department of Biochemistry,Federal University of Rio Grande do Norte,Ave. Senador Salgado Filho 3000,Lagoa Nova,Natal,59072-970,Brazil.
authors.forename: Mayara Santa Rosa
authors.initials: MS
authors.lastname: Lima
authors.affiliation: 2Department of Nutrition,Federal University of Rio Grande do Norte,Ave. Senador Salgado Filho 3000,Lagoa Nova,Natal,59072-970,Brazil.
authors.forename: Renata Alexandra Moreira
authors.initials: RA
authors.lastname: das Neves
authors.affiliation: 1Department of Biochemistry,Federal University of Rio Grande do Norte,Ave. Senador Salgado Filho 3000,Lagoa Nova,Natal,59072-970,Brazil.
authors.forename: Amanda Cibely Pinheiro
authors.initials: AC
authors.lastname: Lima
authors.affiliation: 1Department of Biochemistry,Federal University of Rio Grande do Norte,Ave. Senador Salgado Filho 3000,Lagoa Nova,Natal,59072-970,Brazil.
authors.forename: Raquel Costa Silva
authors.initials: RC
authors.lastname: Dantas
authors.affiliation: 1Department of Biochemistry,Federal University of Rio Grande do Norte,Ave. Senador Salgado Filho 3000,Lagoa Nova,Natal,59072-970,Brazil.
authors.forename: Alyne Batista
authors.initials: AB
authors.lastname: da Silva
authors.affiliation: 1Department of Biochemistry,Federal University of Rio Grande do Norte,Ave. Senador Salgado Filho 3000,Lagoa Nova,Natal,59072-970,Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Dimenstein
mesh_terms: D000293:Adolescent; D000328:Adult; D003126:Colostrum / Q000737:chemistry; D019587:Dietary Supplements; D005260:Female; D005865:Gestational Age; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D039382:Maternal Nutritional Physiological Phenomena; D008875:Middle Aged; D008895:Milk, Human / Q000737:chemistry*; D049590:Postpartum Period; D011247:Pregnancy; D047928:Premature Birth / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage*; D055815:Young Adult; D024502:alpha-Tocopherol / Q000032:analysis*
chemical_list: D014810:Vitamin E; D024502:alpha-Tocopherol
keywords: CG control group; Clinical trials; Dietary supplementation; Intervention studies; Liquid chromatography; SG supplemented group