title: [Lifestyle-related diseases and an inter-organ metabolic network].
abstract: Lifestyle-related diseases such as type 2 diabetes, hypertension and dyslipidemia are a prominent cause of mortality in Japan, and there is a strong requirement for elucidation of detailed molecular mechanisms and effective therapeutic strategies. Obesity-induced adipose tissue inflammation leads to dysregulation of adipokine production, which can cause lifestyle-related diseases. The interaction of organ systems via endocrine or neural networks is recognized as an important factor in the pathogenesis and promotion of lifestyle-related diseases. Therefore, further investigation for the interaction between adipose tissues and bones can provide new treatment strategies of metabolic bone disorders.
authors.affiliation: Department of Molecular Endocrinology and Metabolism,Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Miyachi
authors.affiliation: Department of Molecular Endocrinology and Metabolism,Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
authors.forename: Kyoichiro
authors.initials: K
authors.lastname: Tsuchiya
authors.affiliation: Department of Molecular Endocrinology and Metabolism,Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ogawa
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism*; D008019:Life Style; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D009765:Obesity / Q000378:metabolism*