title: CEACAM1 and MICA as novel serum biomarkers in patients with acute and recurrent pericarditis.
abstract: BACKGROUND
  The immune response plays a significant role in pericarditis, but the mechanisms of disease are poorly defined. Further, efficient monitoring and predictive clinical tools are unavailable. Carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) is an immune-inhibitory protein, while MHC class I chain related protein A (MICA) and B (MICB) have an immune-stimulating function.
  
  
  RESULTS
  Serum CEACAM1, MICA and MICB concentrations were measured by ELISA in ~50 subjects of each group: acute pericarditis (AP), recurrent pericarditis (RP) and lupus (SLE) patients, metastatic melanoma patients as well as healthy donors. Serum CEACAM1 was dramatically elevated in AP and RP patients, but not in SLE patients, and displayed a highly accurate profile in ROC curve analyses. MICA and MICB were elevated in some pericarditis patients. All markers were enhanced in metastatic melanoma patients irrespective of neoplastic pericardial involvement. Etiology-guided analysis of RP patients showed that very low MICA levels were associated with idiopathic RP, while high MICA was associated with autoimmune and post-operative RP. Importantly, MICA was significantly associated with recurrences, independently of other potentially confounding parameters such as age, time of follow up or treatment modality.
  
  
  CONCLUSIONS
  Here we report for the first time on CEACAM1 as a potentially novel biomarker for pericarditis, as well as on MICA as an innovative prognostic marker in these patients. Determination of the roles of these immune factors, as well as their diagnostic and prognostic values should be determined in future prospective studies.
authors.affiliation: Ella Lemelbaum Institute of Melanoma, Sheba Medical Center, Tel Hashomer, Israel.|Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Israel.|Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Gal
authors.initials: G
authors.lastname: Markel
authors.affiliation: Cardiology Department, Maria Vittoria Hospital, Torino, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Imazio
authors.affiliation: Department of Epidemiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Nira
authors.initials: N
authors.lastname: Koren-Morag
authors.affiliation: Ella Lemelbaum Institute of Melanoma, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Gilli
authors.initials: G
authors.lastname: Galore-Haskel
authors.affiliation: Ella Lemelbaum Institute of Melanoma, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Jacob
authors.initials: J
authors.lastname: Schachter
authors.affiliation: Ella Lemelbaum Institute of Melanoma, Sheba Medical Center, Tel Hashomer, Israel.|Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Besser
authors.affiliation: Internal Medicine, Ospedali Riuniti, Bergamo, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Cumetti
authors.affiliation: Internal Medicine, Ospedali Riuniti, Bergamo, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Maestroni
authors.affiliation: Internal Medicine B, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Arie
authors.initials: A
authors.lastname: Altman
authors.affiliation: Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
authors.affiliation: Internal Medicine, Ospedali Riuniti, Bergamo, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Brucato
authors.affiliation: Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Israel.|Cardiac Rehabilitation Institute, Sheba Medical Center, Tel Hashomer, Israel.|Department of Internal Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Adler
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D000075982:Cell Adhesion Molecule-1; D015815:Cell Adhesion Molecules / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000097:blood*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010493:Pericarditis / Q000097:blood*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C403514:CADM1 protein, human; D000075982:Cell Adhesion Molecule-1; D015815:Cell Adhesion Molecules; D015395:Histocompatibility Antigens Class I; D007136:Immunoglobulins; C099187:MHC class I-related chain A; C098080:MICB antigen
keywords: MICA; MICB; biomarkers; pericarditis; serum