title: Physical activity and FTO genotype by physical activity interactive influences on obesity.
abstract: BACKGROUND
  Although the effect of the fat mass and obesity-associated (FTO) gene on adiposity is well established, there is a lack of evidence whether physical activity (PA) modifies the effect of FTO variants on obesity in Latino populations. Therefore, the purpose of this study was to examine PA influences and interactive effects between FTO variants and PA on measures of adiposity in Latinos.
  
  
  RESULTS
  After controlling for age and sex, participants who did not engage in regular PA exhibited higher BMI, fat mass, HC, and WC with statistical significance (P < 0.001). Although significant associations between the three FTO genotypes and adiposity measures were found, none of the FTO genotype by PA interaction assessments revealed nominally significant associations. However, several of such interactive influences exhibited considerable trend towards association.
  
  
  CONCLUSIONS
  These data suggest that adiposity measures are associated with PA and FTO variants in Latinos, but the impact of their interactive influences on these obesity measures appear to be minimal. Future studies with large sample sizes may help to determine whether individuals with specific FTO variants exhibit differential responses to PA interventions.
authors.affiliation: Kinesiology Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ, USA. joonyoung.kim@asu.edu.
authors.forename: Joon Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: College of Health Solutions, School for the Science of Health Care Delivery, Arizona State University, 550N. 3rd Street, Phoenix, 85004, AZ, USA. jacobdemenna@email.arizona.edu.
authors.forename: Jacob T
authors.initials: JT
authors.lastname: DeMenna
authors.affiliation: Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. spuppala@txbiomed.org.
authors.forename: Sobha
authors.initials: S
authors.lastname: Puppala
authors.affiliation: Department of Nutrition and UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA. geethavani_chittoor@unc.edu.
authors.forename: Geetha
authors.initials: G
authors.lastname: Chittoor
authors.affiliation: Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. jschneid74@sbcglobal.net.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Schneider
authors.affiliation: South Texas Diabetes and Obesity Institute Edinburg Regional Academic Health Center University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. ravindranath.duggirala@utrgv.edu.
authors.forename: Ravindranath
authors.initials: R
authors.lastname: Duggirala
authors.affiliation: College of Health Solutions, School for the Science of Health Care Delivery, Arizona State University, 550N. 3rd Street, Phoenix, 85004, AZ, USA. Lawrence.Mandarino@asu.edu.|Mayo/ASU Center for Metabolic and Vascular Biology, Phoenix, AZ, USA. Lawrence.Mandarino@asu.edu.
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Mandarino
authors.affiliation: Kinesiology Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ, USA. Gabriel.Shaibi@asu.edu.|Mayo/ASU Center for Metabolic and Vascular Biology, Phoenix, AZ, USA. Gabriel.Shaibi@asu.edu.|College of Nursing & Health Innovation, Arizona State University, Phoenix, AZ, USA. Gabriel.Shaibi@asu.edu.
authors.forename: Gabriel Q
authors.initials: GQ
authors.lastname: Shaibi
authors.affiliation: College of Health Solutions, School for the Science of Health Care Delivery, Arizona State University, 550N. 3rd Street, Phoenix, 85004, AZ, USA. dawn.coletta@asu.edu.|Mayo/ASU Center for Metabolic and Vascular Biology, Phoenix, AZ, USA. dawn.coletta@asu.edu.
authors.forename: Dawn K
authors.initials: DK
authors.lastname: Coletta
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D050154:Adiposity / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D002648:Child; D015444:Exercise; D005260:Female; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D011795:Surveys and Questionnaires; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human