title: Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer's disease via SIRT1/NF-κB pathway.
abstract: Age-related inflammation is the predominant factor for neurodegenerative diseases like Alzheimer's disease (AD). In the present study, we examined memory performance and neuroinflammation in D-galactose (D-gal)-induced sub-acute aging model of rats. Our results demonstrated that chronic administration of D-gal (120 mg/kg) produced cognitive impairment as determined by Morris water maze (MWM) test and step-down passive avoidance test. D-gal also activated nuclear factor kappa B (NF-κB) p65/RelA by down-regulating the expression level of sirtuins 1 (SIRT1) in the hippocampus. Treatment with Salidroside (Sal, 20, 40 mg/kg) for 28 days ameliorated D-gal-induced memory deficits and inflammatory mediators including tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Moreover, D-gal-induced activation of NF-κB signaling pathway in the brain was also inhibited by Sal via up-regulating SIRT1. These results suggest that D-gal-triggered memory impairment and inflammatory response may be associated with SIRT1/NF-κB signaling pathway, whereas treatment with Sal could positively affect these changes in hippocampus.
authors.affiliation: Department of Physiology and Pharmacology, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Physiology and Pharmacology, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhou
authors.affiliation: Department of Polymer Materials and Engineering, Nanjing Forestry University, Nanjing, 210037, China.
authors.forename: Xintong
authors.initials: X
authors.lastname: You
authors.affiliation: Department of Physiology and Pharmacology, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Luo
authors.affiliation: Department of Physiology and Pharmacology, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: He
authors.initials: H
authors.lastname: He
authors.affiliation: Department of Physiology and Pharmacology, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Xiayun
authors.initials: X
authors.lastname: Chang
authors.affiliation: Department of Physiology and Pharmacology, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Lingpeng
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. dxs0162@sina.com.|China Pharmaceutical University, Tongjiaxiang 24, Nanjing, China. dxs0162@sina.com.
authors.forename: Xuansheng
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Physiology and Pharmacology, China Pharmaceutical University, Nanjing, 210009, China. yantianhuabest@126.com.|China Pharmaceutical University, Tongjiaxiang 24, Nanjing, China. yantianhuabest@126.com.
authors.forename: Tianhua
authors.initials: T
authors.lastname: Yan
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003071:Cognition / Q000187:drug effects; D004195:Disease Models, Animal; D005690:Galactose; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008568:Memory / Q000187:drug effects; D016328:NF-kappa B / Q000378:metabolism*; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects*; D056564:Sirtuin 1 / Q000378:metabolism*
chemical_list: D005960:Glucosides; D016328:NF-kappa B; D010636:Phenols; D056564:Sirtuin 1; C009172:rhodioloside; D005690:Galactose
keywords: Aging; Cognitive impairment; Neuroinflammation; SIRT1/NF-κB pathway; Sal