title: Hypoglycemic and anti-inflammatory effects of seabuckthorn seed protein in diabetic ICR mice.
abstract: In this paper, we have investigated the hypoglycemic and anti-inflammatory effects of seabuckthorn seed protein (SSP) on streptozocin (STZ)-induced diabetic IRC mice. The effects of SSP on the body weight (BW), fasting blood glucose (FBG) levels, serum lipids, inflammatory factors and insulin (SIN) levels of normal and diabetic mice have been investigated. SSP has been shown to reduce insulin resistance (IR) and control the effects of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and nuclear factor-κ-gene binding (NF-κB). In addition, this paper further validates the hypoglycemic and anti-inflammatory effects of seabuckthorn procyanidins (SPR) and seabuckthorn polysaccharides (SPO) in diabetic mice and the experimental results were consistent with previous studies. Moreover, results from animal experiments showed that SSP has a significant hypoglycemic and anti-inflammatory effect as evidenced by the lower BW, FBG levels, SIN and lipid contents of diabetic mice treated with SSP compared to the diabetic control mice.
authors.affiliation: School of Biology and Food Engineering, Hefei University of Technology, Hefei 239000, China. yuanhuaibo001@163.com and Wangjiang Institute of Poultry Technology, Xuancheng Campus, Xuancheng 242000, China.
authors.forename: Huaibo
authors.initials: H
authors.lastname: Yuan
authors.affiliation: School of Biology and Food Engineering, Hefei University of Technology, Hefei 239000, China. yuanhuaibo001@163.com and Wangjiang Institute of Poultry Technology, Xuancheng Campus, Xuancheng 242000, China.
authors.forename: Xiping
authors.initials: X
authors.lastname: Zhu
authors.affiliation: School of Biology and Food Engineering, Hefei University of Technology, Hefei 239000, China. yuanhuaibo001@163.com and Wangjiang Institute of Poultry Technology, Xuancheng Campus, Xuancheng 242000, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Wang
authors.affiliation: School of Biology and Food Engineering, Hefei University of Technology, Hefei 239000, China. yuanhuaibo001@163.com and Wangjiang Institute of Poultry Technology, Xuancheng Campus, Xuancheng 242000, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Meng
authors.affiliation: School of Biology and Food Engineering, Hefei University of Technology, Hefei 239000, China. yuanhuaibo001@163.com and Wangjiang Institute of Poultry Technology, Xuancheng Campus, Xuancheng 242000, China.
authors.forename: Deyi
authors.initials: D
authors.lastname: Chen
authors.affiliation: School of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China.
authors.forename: Cuan
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D031281:Hippophae / Q000737:chemistry*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000378:metabolism; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage*; D010940:Plant Proteins / Q000008:administration & dosage*; D012639:Seeds / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D015850:Interleukin-6; D016328:NF-kappa B; D010936:Plant Extracts; D010940:Plant Proteins; D014409:Tumor Necrosis Factor-alpha