title: Effect of using fluoxetine at different time windows on neurological functional prognosis after ischemic stroke.
abstract: OBJECTIVE
  To evaluate the effect of using fluoxetine at different time intervals after ischemic stroke on neurological functional prognosis in China.
  
  
  METHODS
  The patients enrolled were randomly allocated to three groups. Group A received fluoxetine 20 mg/day immediately; group B received fluoxetine 20 mg/day 7 days after enrollment; and group C did not receive fluoxetine. The therapeutic duration of fluoxetine was 90 days and the follow-up period was 180 days.
  
  
  RESULTS
  The mean NIHSS score at day 90 was significantly lower in group A than group C (P = 0.005), while at day 180, the mean score in group A was significantly lower than groups B and C (P = 0.035, P = 0.000), respectively. The mean BI score at day 90 was significantly higher in group A than group C (P = 0.001), while at day 180, the mean score in group A was significantly higher than groups B and C (P = 0.036, P = 0.000), respectively. Regression analysis indicated that lower NIHSS score and higher BI score at day 180 were attributed to the early administration of fluoxetine.
  
  
  CONCLUSIONS
  In patients with ischemic stroke, early administration of fluoxetine may improve the neurological functional prognosis.
authors.affiliation: Department of Neurology, The Second Clinical Medical College of Jinan University, Guangdong, China.|Department of Neurology, The Shenzhen People's Hospital, Shenzhen, Guangdong, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Neurology, The Second Clinical Medical College of Jinan University, Guangdong, China.|Department of Neurology, The Shenzhen People's Hospital, Shenzhen, Guangdong, China.
authors.forename: Yitao
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Neurology, The Second Clinical Medical College of Jinan University, Guangdong, China.|Department of Neurology, The Shenzhen People's Hospital, Shenzhen, Guangdong, China.
authors.forename: Bingshan
authors.initials: B
authors.lastname: Tang
authors.affiliation: Department of Neurology, The Second Clinical Medical College of Jinan University, Guangdong, China.|Department of Neurology, The Shenzhen People's Hospital, Shenzhen, Guangdong, China.
authors.forename: Kefu
authors.initials: K
authors.lastname: Ma
authors.affiliation: Department of Neurology, The Second Clinical Medical College of Jinan University, Guangdong, China.|Department of Neurology, The Shenzhen People's Hospital, Shenzhen, Guangdong, China.
authors.forename: Zhili
authors.initials: Z
authors.lastname: Cai
authors.affiliation: Department of Neurology, The Second Clinical Medical College of Jinan University, Guangdong, China.|Department of Neurology, The Shenzhen People's Hospital, Shenzhen, Guangdong, China.
authors.forename: Siling
authors.initials: S
authors.lastname: Zeng
authors.affiliation: Department of Neurology, The Second Clinical Medical College of Jinan University, Guangdong, China.|Department of Neurology, The Shenzhen People's Hospital, Shenzhen, Guangdong, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Geriatrics, The Second Clinical Medical College of Jinan University, Guangdong, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects; D002545:Brain Ischemia / Q000150:complications; D002681:China; D004311:Double-Blind Method; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology*; D059906:Neuroimaging; D009460:Neurologic Examination; D010349:Patient Compliance; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D020521:Stroke / Q000150:complications* / Q000209:etiology; D013997:Time Factors; D055815:Young Adult
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Fluoxetine; ischemic stroke; neurological functional prognosis; time intervals