title: The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia.
abstract: Background. Propofol is a popular intravenous anesthetic and varieties of formulations were produced from different laboratories. The present study compared efficacy of propofol of different laboratories and different concentrations (1 and 2%) during induction of anesthesia. Methods. Seventy-five scheduled surgical patients were randomly allocated into three groups. The patients of group D1 received AstraZeneca Diprivan 1% (Osaka, Japan) at a rate of 40 mg kg(-1) h(-1). Group M1 was given 1% Maruishi (Maruishi Pharmaceutical, Osaka, Japan) and group M2 was given 2% formulation at the same rate of propofol. Achieving hypnosis was defined as failure to open their eyes in response to a verbal command and the venous blood sample was withdrawn. Results. The hypnotic doses of M2 were significantly larger (D1: 91.4 ± 30.9, M1: 90.7 ± 26.7, and M2: 118.4 ± 40.2 mg, resp. (mean ± SD). p < 0.005). Age and gender were selected as statistically significant covariates using general linear model-ANOVA. The blood concentration showed no significant difference among the groups (3.73 ± 2.34, 4.10 ± 3.04, and 4.70 ± 2.12 μg mL(-1), resp.). Conclusion. The required dose of propofol was different among the formulations; however, the serum concentration showed no significant difference. This trial is registered with UMIN Clinical Trial Registry: UMIN000019925.
authors.affiliation: Department of Intensive Care Unit, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 4313192, Japan.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Obata
authors.affiliation: Department of Intensive Care Medicine, Tokyo Medical and Dental University Medical Hospital, Tokyo, Japan.
authors.forename: Yushi U
authors.initials: YU
authors.lastname: Adachi
authors.affiliation: Department of Anesthesia, Enshu Hospital, Hamamatsu, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, USA.
authors.forename: Taiga
authors.initials: T
authors.lastname: Itagaki
authors.affiliation: Department of Intensive Care Unit, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 4313192, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kato
authors.affiliation: Department of Anesthesiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Satomoto
authors.affiliation: Department of Intensive Care Unit, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 4313192, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nakajima