title: Multiplicative and Additive Modulation of Neuronal Tuning with Population Activity Affects Encoded Information.
abstract: Numerous studies have shown that neuronal responses are modulated by stimulus properties and also by the state of the local network. However, little is known about how activity fluctuations of neuronal populations modulate the sensory tuning of cells and affect their encoded information. We found that fluctuations in ongoing and stimulus-evoked population activity in primate visual cortex modulate the tuning of neurons in a multiplicative and additive manner. While distributed on a continuum, neurons with stronger multiplicative effects tended to have less additive modulation and vice versa. The information encoded by multiplicatively modulated neurons increased with greater population activity, while that of additively modulated neurons decreased. These effects offset each other so that population activity had little effect on total information. Our results thus suggest that intrinsic activity fluctuations may act as a "traffic light" that determines which subset of neurons is most informative.
authors.affiliation: Department of Information and Communication Technologies, Universidad Pompeu Fabra, Barcelona 08018, Spain; Research Unit, Parc Sanitari Sant Joan de Deu, Esplugues de Llobregat, Barcelona 08950, Spain.
authors.forename: Iñigo
authors.initials: I
authors.lastname: Arandia-Romero
authors.affiliation: Dominick Purpura Department of Neuroscience and Ophthalmology and Visual Science, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Seiji
authors.initials: S
authors.lastname: Tanabe
authors.affiliation: Département des Neurosciences Fondamentales, Université de Genève, 1211 Geneva 4, Switzerland.
authors.forename: Jan
authors.initials: J
authors.lastname: Drugowitsch
authors.affiliation: Dominick Purpura Department of Neuroscience and Ophthalmology and Visual Science, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Kohn
authors.affiliation: Department of Information and Communication Technologies, Universidad Pompeu Fabra, Barcelona 08018, Spain; Research Unit, Parc Sanitari Sant Joan de Deu, Esplugues de Llobregat, Barcelona 08950, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Esplugues de Llobregat, Barcelona 08950, Spain; Serra Húnter Fellow Programme, Universidad Pompeu Fabra, Barcelona 08018, Spain. Electronic address: ruben.moreno@upf.edu.
authors.forename: Rubén
authors.initials: R
authors.lastname: Moreno-Bote
mesh_terms: D000818:Animals; D016015:Logistic Models; D008252:Macaca fascicularis; D008297:Male; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009949:Orientation / Q000502:physiology*; D010775:Photic Stimulation; D014793:Visual Cortex / Q000166:cytology*