title: Anion Specificity of Polyzwitterionic Brushes with Different Carbon Spacer Lengths and Its Application for Controlling Protein Adsorption.
abstract: Both ion-specific interaction and carbon spacer length have strong effects on the properties of polyzwitterions. In this work, we have investigated the anion specificity of poly(sulfobetaine methacrylamide) (PSBMAm) brushes with different carbon spacer lengths. The effectiveness of anions to enhance the hydration of the PSBMAm brushes increases from kosmotropic to chaotropic anions. The interactions between the anions and the PSBMAm brushes are strongly influenced by carbon spacer length because the strength of inter/intrachain association of the PSBMAm brushes decreases with increasing carbon spacer length. The inter/intrachain association of the PSBMAm brushes with a longer carbon spacer is easier to break by the external anions in the high salt concentration regime. On the other hand, a longer carbon spacer is more favorable for the zwitterionic groups to form cyclic intramolecular structures. As a result, the addition of anions can more effectively enhance the hydration of the PSBMAm brushes with a medium-length carbon spacer compared with that of the PSBMAm brushes with a either shorter or longer carbon spacer in the low salt concentration regime, determined by the balance between the inter/intrachain association and the formation of cyclic intramolecular structures. Our study also demonstrates that both anion identity and carbon spacer length can be used to control protein adsorption on the surface of the PSBMAm brushes.
authors.affiliation: Department of Chemical Physics, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China , 230026 Hefei, P. R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Chemical Physics, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China , 230026 Hefei, P. R. China.
authors.forename: Ran
authors.initials: R
authors.lastname: Kou
authors.affiliation: Department of Chemical Physics, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China , 230026 Hefei, P. R. China.
authors.forename: Huili
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Chemical Physics, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China , 230026 Hefei, P. R. China.
authors.forename: Lvdan
authors.initials: L
authors.lastname: Liu
authors.affiliation: Faculty of Materials Science and Engineering, South China University of Technology , 510640 Guangzhou, P. R. China.
authors.forename: Guangzhao
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Chemical Physics, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China , 230026 Hefei, P. R. China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Liu
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry*; D000327:Adsorption; D000818:Animals; D000838:Anions; D001622:Betaine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D002417:Cattle; D015394:Molecular Structure; D009113:Muramidase / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D014867:Water
chemical_list: D000180:Acrylic Resins; D000838:Anions; D014867:Water; D012710:Serum Albumin, Bovine; D001622:Betaine; D009113:Muramidase