title: [Clinical Significance of P53, C-MYC and BCL-6 Abnormality in Patients with Diffuse Large B Cell Lymphoma].
abstract: OBJECTIVE
  To study the clinical significance of P53, C-MYC and BCL-6 abnormality in the patients with diffuse large B cell lymphoma (DLBCL).
  
  
  METHODS
  From July 2011 to January 2013, 80 patients with DLBCL were admitted in our hospital and were chosen as study objects, their clinical data were collected. The abnormality of P53, C-MYC and BCL-6 was examined by using I-FISH for all the patients. The correlation of abnormality of P53, C-MYC and BCL-6 with clinical staging, curative efficacy and prognosis of the patients were analyzed.
  
  
  RESULTS
  Out of 80 patients 27 patients (33.75%) had P53 deletion, 24 patients (30.00%) had C-MYC rearrangement/amplification, and 46 patients (57.50%) had BCL-6 rearrangement. The P53 deletion, C-MYC rearrangement/amplification and BCL-6 rearrangement significantly correlated with staging, curative effect and prognosis of the patients (P < 0.05).
  
  
  CONCLUSIONS
  The curative efficacy and prognosis of the DLBCL patients with abnormality of P53, C-MYC and BCL-6 have been confirmed to be unsatisfactory.
authors.affiliation: Department of Blood Transfusion, Hengshui Harrison International Peace Hospital, Hengshui 053000, Hebei Province, China. E-mail: chchguo@163.com.
authors.forename: Cheng-Guo
authors.initials: CG
authors.lastname: Chai
authors.affiliation: Department of Emergency, Hengshui Harrison International Peace Hospital, Hengshui 053000, Hebei Province, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Department of Laboratorial Examination, Hengshui Harrison International Peace Hospital, Hengshui 053000, Hebei Province, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Nephrology, Hengshui Harrison International Peace Hospital, Hengshui 053000, Hebei Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Hepatobiliary Surgery, Hengshui Harrison International Peace Hospital, Hengshui 053000, Hebei Province, China.
authors.forename: Shuang-Yang
authors.initials: SY
authors.lastname: Zhang
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D051560:Proto-Oncogene Proteins c-bcl-6; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; C489427:MYC protein, human; D051560:Proto-Oncogene Proteins c-bcl-6; D016271:Proto-Oncogene Proteins c-myc; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53