title: Hydroa Vacciniforme-Like EBV-Positive Cutaneous T-Cell Lymphoma, First Report of 2 Cases in Ecuador.
abstract: Hydroa vacciniforme-like cutaneous lymphoma is a very rare Epstein-Barr virus positive peripheral T-cell lymphoma affecting Asian and Hispanic children and young adults with a defective cytotoxic immune response to EBV predisposing to the development of the disease. We report on 2 Ecuadorian patients with papulovesicular and ulcerated crusted lesions on the face, upper and lower extremities and abdomen, with aggressive clinical course and, in one case, a fatal outcome. The histological and molecular profiles (immunohistochemistry and in situ hybridization) established a diagnosis of hydroa vacciniforme-like Epstein-Barr virus-encoded small RNAs + cutaneous T-cell lymphoma in both cases.
authors.affiliation: Servicio de Patología, Hospital Metropolitano, Quito, Ecuador.
authors.forename: Nelson
authors.initials: N
authors.lastname: Montalvo
authors.forename: Ligia
authors.initials: L
authors.lastname: Redrobán
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D004484:Ecuador; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D017809:Fatal Outcome; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D054884:Host-Pathogen Interactions; D006801:Humans; D006837:Hydroa Vacciniforme / Q000276:immunology / Q000473:pathology / Q000821:virology*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology / Q000821:virology*; D008297:Male; D012367:RNA, Viral / Q000235:genetics; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology / Q000821:virology*
chemical_list: D014408:Biomarkers, Tumor; D012367:RNA, Viral