title: Early oral feeding after total laryngectomy: Outcome of 602 patients in one cancer center.
abstract: OBJECTIVE
  Pharyngocutaneous fistula (PCF) is the most frequent complication after total laryngectomy. However, delayed oral feeding and inserting a nasogastric tube has been considered as a safe practice among head and neck surgeons, and there is no general agreement on the initiation of the oral intake. The aim of the study is to determine the incidence of PCF after primary total laryngectomy in a large homogenous case series and to evaluate whether fistula and early oral feeding are related.
  
  
  METHODS
  Patients who underwent total laryngectomy/laryngopharyngectomy with primary closure of pharynx between 1990 and 2014 were reviewed. Patients who had a history of previous radiotherapy, chemotherapy or chemoradiotherapy, and patients who underwent more complex reconstruction techniques (e.g. pedicled or free flaps) for closure were excluded. In total, 602 patients underwent total laryngectomy (n=580) or total laryngectomy plus partial pharyngectomy (n=22).
  
  
  RESULTS
  The overall PCF rate was 12%. In 582 of the 602 patients (99.8%), a nasogastric tube was not inserted. In 95.7% of the patients (576/602), oral feeding was started within 3 days of surgery. Among the patients who developed PCF (72/602), PCF rate was not significantly higher in early oral fed patients (69/582, 11.8%) than the patients with nasogastric tube insertion (3/20, 15%) (p=0.722).
  
  
  CONCLUSIONS
  The low PCF rate in our study indicates that early oral feeding is a safe and effective method in primary total laryngectomy.
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Hacettepe University Faculty of Medicine, Turkey. Electronic address: nildasuslu@yahoo.com.
authors.forename: Nilda
authors.initials: N
authors.lastname: Süslü
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Hacettepe University Faculty of Medicine, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Şefik Hoşal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000601:surgery*; D017577:Cutaneous Fistula / Q000453:epidemiology*; D005248:Feeding Methods / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D010608:Pharyngeal Diseases / Q000453:epidemiology*; D010610:Pharyngeal Neoplasms / Q000601:surgery*; D010611:Pharyngectomy; D011182:Postoperative Care; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult
keywords: Early oral feeding; Phayngocutaneous fistula; Total laryngectomy