title: Brief Report: Sensory Reactivity in Children with Phelan-McDermid Syndrome.
abstract: Phelan-McDermid syndrome (PMS), a monogenic form of autism spectrum disorder (ASD), results from deletion or mutation of the SHANK3 gene. Atypical sensory reactivity is now included in the diagnostic criteria for ASD. Examining the sensory phenotype in monogenic forms of ASD, such as PMS, may help identify underlying mechanisms of sensory reactivity. Using the Short Sensory Profile, the current study compared sensory reactivity in 24 children with PMS to 61 children with idiopathic ASD (iASD). Results suggest that children with PMS show more low energy/weak symptoms and less sensory sensitivity as compared to children with iASD. This study is the first to demonstrate differences in sensory reactivity between children with PMS and iASD, helping to refine the PMS phenotype.
authors.affiliation: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA. alexa.mieses@icahn.mssm.edu.
authors.forename: A M
authors.initials: AM
authors.lastname: Mieses
authors.affiliation: Seaver Autism Center for Research and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.
authors.forename: T
authors.initials: T
authors.lastname: Tavassoli
authors.affiliation: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.
authors.forename: E
authors.initials: E
authors.lastname: Li
authors.affiliation: Department of Psychiatry, Rush University Medical Center, Chicago, IL, USA.
authors.forename: L
authors.initials: L
authors.lastname: Soorya
authors.affiliation: Seaver Autism Center for Research and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.
authors.forename: S
authors.initials: S
authors.lastname: Lurie
authors.affiliation: Seaver Autism Center for Research and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Wang
authors.affiliation: Seaver Autism Center for Research and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Siper
authors.affiliation: Seaver Autism Center for Research and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.|Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.|Mindich Child Health Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: A
authors.initials: A
authors.lastname: Kolevzon
mesh_terms: D000067877:Autism Spectrum Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007805:Language Development Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D008137:Longitudinal Studies; D008297:Male; D010641:Phenotype; D012678:Sensation Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology
keywords: 22q13 deletion syndrome; Autism; Autism spectrum disorder; Phelan–McDermid syndrome; Sensory profile; Sensory reactivity