title: Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease.
abstract: Leishmaniasis is a group of neglected diseases whose clinical manifestations depend on factors from the host and the pathogen. It is an important public health problem worldwide caused by the protozoan parasite from the Leishmania genus. Cutaneous Leishmaniasis (CL) is the most frequent form of this disease transmitted by the bite of an infected sandfly into the host skin. The parasites can be uptook and/or recognized by macrophages, neutrophils, and/or dendritic cells (DCs). Initially, DCs were described to play a protective role in activating the immune response against Leishmania parasites. However, several reports showed a dichotomic role of DCs in modulating the host immune response to susceptibility or resistance in CL. In this review, we discuss (1) the interactions between DCs and parasites from different species of Leishmania and (2) the crosstalk of DCs and other cells during CL infection. The complexity of these interactions profoundly affects the adaptive immune response and, consequently, the disease outcome, especially from Leishmania species of the New World.
authors.affiliation: Centro de Pesquisas Gonçalo Moniz (CPqGM), 40296-710 Salvador, BA, Brazil.
authors.forename: Daniel
authors.initials: D
authors.lastname: Feijó
authors.affiliation: Centro de Pesquisas Gonçalo Moniz (CPqGM), 40296-710 Salvador, BA, Brazil; Universidade Federal da Bahia (UFBA), 40170-115 Salvador, BA, Brazil.
authors.forename: Rafael
authors.initials: R
authors.lastname: Tibúrcio
authors.affiliation: Centro de Pesquisas Gonçalo Moniz (CPqGM), 40296-710 Salvador, BA, Brazil; Universidade Federal da Bahia (UFBA), 40170-115 Salvador, BA, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Ampuero
authors.affiliation: Centro de Pesquisas Gonçalo Moniz (CPqGM), 40296-710 Salvador, BA, Brazil; Universidade Federal da Bahia (UFBA), 40170-115 Salvador, BA, Brazil; Instituto de Investigação em Imunologia (iii), 01246-903 São Paulo, SP, Brazil.
authors.forename: Cláudia
authors.initials: C
authors.lastname: Brodskyn
authors.affiliation: Centro de Pesquisas Gonçalo Moniz (CPqGM), 40296-710 Salvador, BA, Brazil.
authors.forename: Natalia
authors.initials: N
authors.lastname: Tavares
mesh_terms: D000818:Animals; D003198:Computer Simulation; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology* / Q000469:parasitology*; D006801:Humans; D007891:Leishmania / Q000145:classification / Q000276:immunology* / Q000469:parasitology; D016773:Leishmaniasis, Cutaneous / Q000276:immunology* / Q000469:parasitology / Q000628:therapy; D008264:Macrophages / Q000276:immunology; D051379:Mice; D009504:Neutrophils / Q000276:immunology; D016052:Protozoan Vaccines / Q000276:immunology; D049490:Systems Biology
chemical_list: D016052:Protozoan Vaccines