title: [Q fever : A rare differential diagnosis of granulomatous disease].
abstract: Q fever is a worldwide distributed zoonotic disease with a mostly benign course, which regularly reoccurs in Germany. This report is about a patient with sporadic serologically proven Q fever, which also showed typical histopathological findings with nonspecific granulomatous hepatitis, usually seen in acute disease. The bone marrow biopsy revealed so-called doughnut granulomas, which are not pathognomonic but a typical finding in Q fever. This case report impressively underlines that the histomorphological findings can make a decisive contribution to the clarification by extended differential diagnostics, even though it plays a subordinate role in the routine diagnostics of disseminated Q fever.
authors.affiliation: Institut für Pathologie und Tumordiagnostik, Klinikum St. Georg gGmbH, Delitzscher Str. 141, 04129, Leipzig, Deutschland. sabinehippe@gmx.de.
authors.forename: S
authors.initials: S
authors.lastname: Hippe
authors.affiliation: Klinik für Infektiologie/Tropenmedizin, Nephrologie und Rheumatologie, Klinikum St. Georg gGmbH, Delitzscher Str. 141, 04129, Leipzig, Deutschland.
authors.forename: N
authors.initials: N
authors.lastname: Kellner
authors.affiliation: Universitätsklinik und Poliklinik für Geburtshilfe, Universitätsklinikum Halle (Saale), Halle/Saale, Deutschland.
authors.forename: G
authors.initials: G
authors.lastname: Seliger
authors.affiliation: Institut für Pathologie und Tumordiagnostik, Klinikum St. Georg gGmbH, Delitzscher Str. 141, 04129, Leipzig, Deutschland.
authors.forename: V
authors.initials: V
authors.lastname: Wiechmann
authors.affiliation: Klinik für Infektiologie/Tropenmedizin, Nephrologie und Rheumatologie, Klinikum St. Georg gGmbH, Delitzscher Str. 141, 04129, Leipzig, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Grünewald
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001021:Aortic Valve / Q000473:pathology; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D006105:Granulomatous Disease, Chronic / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D006506:Hepatitis A / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D011778:Q Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D035583:Rare Diseases; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents
keywords: Coxiella burnetii; Doughnut granuloma; Granulomatous disease; Granulomatous hepatitis; Q fever