title: Oridonin Suppresses Proliferation of Human Ovarian Cancer Cells via Blockage of mTOR Signaling.
abstract: Oridonin, an ent-kaurane diterpenoid compound isolated from the traditional Chinese herb Rabdosia rubescens, has shown various pharmacological and physiological effects such as anti-tumor, anti-bacterial, and anti-inflammatory properties. However, the effect of oridonin on human ovarian cancer cell lines has not been determined. In this study, we demonstrated that oridonin inhibited ovarian cancer cell proliferation, migration and invasion in a dose-dependent manner. Furthermore, we showed oridonin inhibited tumor growth of ovarian cancer cells (SKOV3) in vivo. We then assessed mechanisms and found that oridonin specifically abrogated the phosphorylation/activation of mTOR signaling. In summary, our results indicate that oridonin is a potential inhibitor of ovarian cancer by blocking the mTOR signaling pathway.
authors.affiliation: Department of Transfusion, Huashan Hospital, Fudan University, Shanghai, P. R. China E-mail : amdeng70@163.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Xia
authors.forename: Sun-Xiao
authors.initials: SX
authors.lastname: Chen
authors.forename: Qin
authors.initials: Q
authors.lastname: Qin
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Zhang
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: Zhu
authors.forename: An-Mei
authors.initials: AM
authors.lastname: Deng
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D045786:Diterpenes, Kaurane / Q000494:pharmacology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D037602:Isodon / Q000737:chemistry; D051379:Mice; D016513:Mice, SCID; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D010766:Phosphorylation; D015398:Signal Transduction / Q000187:drug effects; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014945:Wound Healing / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; C011959:oridonin; D058570:TOR Serine-Threonine Kinases