title: Targeting the hedgehog pathway for gallbladder cancer therapy?
abstract: Gallbladder carcinoma is a fatal malignancy of hepatobiliary tract that is generally diagnosed at advanced stages of cancer because of its asymptomatic nature. Advanced GBC tumors are unresectable with poor prognosis. Improvement in GBC patient care requires better understanding of the biological signaling pathways and application of newly discovered drugs for cancer therapy. Herein, we discuss the possibilities and challenges in targeting the hedgehog pathway in gallbladder cancer therapy based on recent developments in the area.
authors.affiliation: Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, UP, India. balrajmittal@gmail.com or balraj@sgpgi.ac.in.
authors.forename: Balraj
authors.initials: B
authors.lastname: Mittal
authors.affiliation: Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, UP, India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Yadav
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005706:Gallbladder Neoplasms / Q000188:drug therapy*; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors*; D006801:Humans; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D053823:Hedgehog Proteins
keywords: Gallbladder neoplasms; biliary tract cancer; hedgehog pathway; molecular targeted therapy