title: Collision tumour of large-cell neuroendocrine carcinoma and adenocarcinoma in the stomach: A case report.
abstract: Concurrence of adenocarcinoma and large-cell neuroendocrine carcinoma of the stomach is a rare condition. Here, we report a case of gastric collision tumour with large-cell neuroendocrine carcinoma and adenocarcinoma. A 71-year-old Peruvian man presented with nausea, epigastric pain, and weight loss for seven months. An Endoscopic evaluation revealed a huge ulcerative and infiltrative mass in the upper and middle third of the stomach. The patient underwent a D2 total gastrectomy. Microscopically, two separated and attached ulcerative lesions were recognised. The proximal to the cardial lesion showed neuroendocrine morphology and immunoreactivity for synaptophysin, and the other a moderated tubular adenocarcinoma Borrmann type III. Both lesions invaded serosa and lymph nodes metastases were found in 17 of 41 lymph nodes retrieved (one lymph node with neuroendocrine metastatic deposits).
authors.affiliation: Clínica Anglo Americana, Calle Alfredo Salazar S/N, San Isidro, Lima 18, Peru.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Payet
authors.affiliation: Clínica Delgado, Avenida Angamos Oesta cuadra 4, Miraflores, Lima 27, Peru.
authors.forename: Pau I
authors.initials: PI
authors.lastname: Pilco
authors.affiliation: Clínica Anglo Americana, Calle Alfredo Salazar S/N, San Isidro, Lima 18, Peru.
authors.forename: Jaime
authors.initials: J
authors.lastname: Montes
authors.affiliation: Universidad Peruana de Ciencias Aplicadas, Prolongación Primavera 2390, Santiago de Surco, Lima 33, Peru.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Cordero-Morales
authors.affiliation: Universidad Peruana de Ciencias Aplicadas, Prolongación Primavera 2390, Santiago de Surco, Lima 33, Peru.
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Savitzky
authors.affiliation: Universidad Peruana de Ciencias Aplicadas, Prolongación Primavera 2390, Santiago de Surco, Lima 33, Peru.
authors.forename: Karoline
authors.initials: K
authors.lastname: Stenning-Persivale
keywords: adenocarcinoma; carcinoma; collision tumour; neuroendocrine