title: Mycobacterium tuberculosis: Manipulator of Protective Immunity.
abstract: Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history and remains a global health challenge. MTB has evolved a plethora of strategies to evade the immune response sufficiently to survive within the macrophage in a bacterial-immunological equilibrium, yet causes sufficient immunopathology to facilitate its transmission. This review highlights MTB as the driver of disease pathogenesis and presents evidence of the mechanisms by which MTB manipulates the protective immune response into a pathological productive infection.
authors.affiliation: Discipline of Medical Biochemistry and Chemical Pathology, University of KwaZulu-Natal, Howard College Campus, King George V Avenue, 4001 Durban, South Africa. vanessakorb@gmail.com.
authors.forename: Vanessa C
authors.initials: VC
authors.lastname: Korb
authors.affiliation: Discipline of Medical Biochemistry and Chemical Pathology, University of KwaZulu-Natal, Howard College Campus, King George V Avenue, 4001 Durban, South Africa. chutur@ukzn.ac.za.
authors.forename: Anil A
authors.initials: AA
authors.lastname: Chuturgoon
authors.affiliation: Discipline of Medical Biochemistry and Chemical Pathology, University of KwaZulu-Natal, Howard College Campus, King George V Avenue, 4001 Durban, South Africa. Devan_Moodley@hms.harvard.edu.
authors.forename: Devapregasan
authors.initials: D
authors.lastname: Moodley
mesh_terms: D000818:Animals; D006801:Humans; D057131:Immune Evasion; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000472:pathogenicity; D014375:Tuberculoma / Q000276:immunology* / Q000382:microbiology
keywords: foamy macrophage; granuloma; mycobacterium; tuberculosis