title: Metabolic Control of Plasma Cell Differentiation- What We Know and What We Don't Know.
abstract: Antibody secretion is executed by plasma cells that are generated in the periphery and migrate to the bone marrow to establish a long lived pool. The terminal differentiation of B lymphocytes into plasma cells is executed by a network of transcription factors that cross-regulate each other in order to irreversibly promote this transition. While major progress has been made in the understanding the transcriptional activity of the underlying master regulators, much less is known on the metabolic regulation of plasma cell differentiation that is required to support antibody synthesis, folding and secretion at high levels and allow their long-lasting survival. In this review we will address the known cross talks between the transcription and metabolic control of plasma cells and elaborate on the gaps of knowledge in the field.
authors.affiliation: Institute for Drug Research, The School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Aronov
authors.affiliation: Institute for Drug Research, The School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel. boazt@ekmd.huji.ac.il.
authors.forename: Boaz
authors.initials: B
authors.lastname: Tirosh
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation; D004734:Energy Metabolism; D006801:Humans; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D010950:Plasma Cells / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D013312:Stress, Physiological / Q000235:genetics / Q000276:immunology; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D058570:TOR Serine-Threonine Kinases
keywords: ER stress; RIDD; TSC; UPR; mTOR; oxidative stress; plasma cells