title: Maternal 75-g OGTT glucose levels as predictive factors for large-for-gestational age newborns in women with gestational diabetes mellitus.
abstract: OBJECTIVE
  Our goal was to investigate which glucose measurement from the 75-g oral glucose tolerance test (OGTT) has more capability of predicting large for-gestational-age (LGA) newborns of mothers with gestational diabetes mellitus (GDM).
  
  
  METHODS
  The study group consisted of 118 consecutively pregnant women with singleton pregnancy, patients of Outpatients Department of the Endocrinology, Diabetes, and Metabolic Disorders Clinic. All were prospectively screened for GDM between 24th and 28th week of pregnancy and followed to delivery. Outcome measures included: patients' ages, pre-pregnancy BMI, BMI before delivery, FPG, 1 and 2 hour OGTT glucose values, haemoglobin A1c at third trimester, gestational week of delivery, mode of delivery and baby birth weight.
  
  
  RESULTS
  From 118 pregnancies, 78 (66.1%) women were with GDM, and 40 (33.9%) without GDM. There were statistically significant differences (30.7 versus 5.0%, p < 0.01) between LGA newborns from GDM and control group, respectively. Gestation week of delivery and fasting glucose levels were independent predictors for LGA (Beta = 0.58 and Beta = 0.37 respectively, p < 0.01). Areas under the receiver operator characteristic curve (AUC) were compared for the prediction of LGA (0.782 (0.685-0.861) for fasting, 0.719 (0.607-0.815) for 1-hour and 0.51 (0.392-0.626) for 2-hour OGTT plasma glucose levels).
  
  
  CONCLUSIONS
  Fasting and 1-hour plasma glucose levels from OGTT may predict LGA babies in GDM pregnancies.
authors.affiliation: Endocrinology Diabetes and Metabolic Disorders Clinic, Medical Faculty, Skopje, R. Macedonia.
authors.forename: Krstevska
authors.initials: K
authors.lastname: Brankica
authors.affiliation: Faculty of Medical Science, Goce Delcev University, Stip, R. Macedonia.
authors.forename: Velkoska Nakova
authors.initials: VN
authors.lastname: Valentina
authors.affiliation: Gynecology and Obstetric Clinic, Medical Faculty, Skopje, R. Macedonia.
authors.forename: Simeonova Krstevska
authors.initials: SK
authors.lastname: Slagjana
authors.affiliation: Endocrinology Diabetes and Metabolic Disorders Clinic, Medical Faculty, Skopje, R. Macedonia.
authors.forename: Jovanovska Mishevska
authors.initials: JM
authors.lastname: Sasha
mesh_terms: D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D049628:Body Size / Q000502:physiology; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D005320:Fetal Macrosomia / Q000175:diagnosis*; D005865:Gestational Age; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D001786:Blood Glucose