title: Clinical characteristics associated with mortality of patients with anaerobic bacteremia.
abstract: The presence of anaerobes in the blood stream is known to be associated with a higher rate of mortality. However, few prognostic risk factor analyses examining whether a patient's background characteristics are associated with the prognosis have been reported. We performed a retrospective case-controlled study to assess the prognostic factors associated with death from anaerobic bacteremia. Seventy-four patients with anaerobic bacteremia were treated between January 2005 and December 2014 at Aichi Medical University Hospital. The clinical information included drug susceptibility was used for analysis of prognostic factors for 30-day mortality. Multivariate logistic analyses revealed an association between the 30-day mortality rate and malignancy (OR: 3.64, 95% CI: 1.08-12.31) and clindamycin resistance (OR: 7.93, 95% CI: 2.33-27.94). The result of Kaplan-Meier analysis of mortality showed that the 30-day survival rate was 83% in clindamycin susceptible and 38.1% in clindamycin resistant anaerobes causing bacteremia. The result of log-rank test also showed that susceptibility to clindamycin affected mortality (P < 0.001). Our results indicated that malignancy and clindamycin susceptibility could be used to identify subgroups of patients with anaerobic bacteremia with a higher risk of 30-day mortality. The results of this study are important for the early and appropriate management of patients with anaerobic bacteremia.
authors.affiliation: Department of Clinical Infectious Diseases, Aichi Medical University Graduate School of Medicine, Japan; Department of Pharmacy, Tosei General Hospital, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Umemura
authors.affiliation: Department of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Hamada
authors.affiliation: Department of Clinical Infectious Diseases, Aichi Medical University Graduate School of Medicine, Japan; Department of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yamagishi
authors.affiliation: Department of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suematsu
authors.affiliation: Department of Clinical Infectious Diseases, Aichi Medical University Graduate School of Medicine, Japan; Department of Infection Control and Prevention, Aichi Medical University Hospital, Japan. Electronic address: mikamo@aichi-med-u.ac.jp.
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Mikamo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D001421:Bacteria, Anaerobic / Q000254:growth & development / Q000302:isolation & purification; D016866:Bacteroidaceae Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D001439:Bacteroides / Q000254:growth & development / Q000302:isolation & purification; D001442:Bacteroides Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D016022:Case-Control Studies; D002981:Clindamycin / Q000627:therapeutic use; D003013:Clostridium / Q000254:growth & development / Q000302:isolation & purification; D003015:Clostridium Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D018720:Prevotella / Q000254:growth & development / Q000302:isolation & purification; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin
keywords: Anaerobe; Anaerobic bacteremia; Blood stream infection; Clindamycin; Prognostic factor