title: A Chemopreventive Nanodiamond Platform for Oral Cancer Treatment.
abstract: Standard oral cancer therapy generally includes a combination of surgery with chemotherapy and/or radiotherapy. This treatment paradigm has not changed in some time. In this paper, we propose a chemopreventive nanodiamond platform for the delivery of celecoxib (Celebrex) to oral cancer lesions. This innovative platform allows for sustained drug release under physiological conditions, potentially enhancing chemopreventive efficacy of celecoxib without the physical and toxicological damage associated with conventional means of drug delivery.
authors.forename: Albert
authors.initials: A
authors.lastname: Yen
authors.forename: Kangyi
authors.initials: K
authors.lastname: Zhang
authors.forename: Giulia
authors.initials: G
authors.lastname: Daneshgaran
authors.forename: Ho-Joong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Dean
authors.initials: D
authors.lastname: Ho
mesh_terms: D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D000068579:Celecoxib / Q000008:administration & dosage*; D018890:Chemoprevention; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D009062:Mouth Neoplasms / Q000517:prevention & control*; D058612:Nanodiamonds / Q000008:administration & dosage* / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D016588:Anticarcinogenic Agents; D052246:Cyclooxygenase 2 Inhibitors; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D058612:Nanodiamonds; C507107:PEI-g-PEG-RGD; D010456:Peptides, Cyclic; D011092:Polyethylene Glycols; D000068579:Celecoxib