title: The Penn Parkinson's Daily Activities Questionnaire-15: Psychometric properties of a brief assessment of cognitive instrumental activities of daily living in Parkinson's disease.
abstract: BACKGROUND
  To describe the psychometric properties of the Penn Parkinson's Daily Activities Questionnaire-15 (PDAQ-15), a 15-item measure of cognitive instrumental activities of daily living for Parkinson's disease (PD) patients derived from the original 50-item PDAQ.
  
  
  METHODS
  PDAQ-15 items were chosen by expert consensus. Knowledgeable informants of PD participants (n = 161) completed the PDAQ-15. Knowledgeable informants were defined as an individual having regular contact with the PD participant. PD participants were assigned a diagnosis of normal cognition, mild cognitive impairment, or dementia based on expert consensus.
  
  
  RESULTS
  PDAQ-15 scores correlated strongly with global cognition (Dementia Rating Scale-2, r = 0.71, p < 0.001) and a performance-based functional measure (Direct Assessment of Functional Status, r = 0.83; p < 0.001). PDAQ-15 scores accurately discriminated between non-demented PD participants (normal cognition/mild cognitive impairment) and PD with dementia (ROC curve area = 0.91), participants with and without any cognitive impairment (normal cognition versus mild cognitive impairment/dementia, ROC curve area = 0.85) and between participants with mild cognitive impairment and dementia (ROC curve area = 0.84).
  
  
  CONCLUSIONS
  The PDAQ-15 shows good discriminant validity across cognitive stages, correlates highly with global cognitive performance, and appears suitable to assess daily cognitive functioning in PD.
authors.affiliation: Drexel Neurosciences Institute, Drexel University College of Medicine, 245 N. 15th St., 7102 NCB, Philadelphia, PA 19102, USA; Department of Psychiatry, University of Pennsylvania School of Medicine, 3615 Chestnut St., #330, Philadelphia, PA 19104, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Brennan
authors.affiliation: Avid Radiopharmaceuticals, 3711 Market St # 7, Philadelphia, PA 19104, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Siderowf
authors.affiliation: National Board of Medical Examiners, 3750 Market Street, Philadelphia, PA 19104, USA.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Rubright
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, 330 S. 9th St., Philadelphia, PA 19107, USA.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Rick
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, 330 S. 9th St., Philadelphia, PA 19107, USA.
authors.forename: Nabila
authors.initials: N
authors.lastname: Dahodwala
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, 330 S. 9th St., Philadelphia, PA 19107, USA; Philadelphia Veterans Affairs Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA.
authors.forename: John E
authors.initials: JE
authors.lastname: Duda
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, 330 S. 9th St., Philadelphia, PA 19107, USA.
authors.forename: Howard
authors.initials: H
authors.lastname: Hurtig
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, 330 S. 9th St., Philadelphia, PA 19107, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Stern
authors.affiliation: Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 8th Floor Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA.
authors.forename: Sharon X
authors.initials: SX
authors.lastname: Xie
authors.affiliation: Philadelphia Veterans Affairs Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA.
authors.forename: Lior
authors.initials: L
authors.lastname: Rennert
authors.affiliation: Departments of Medical Ethics and Medicine, PENN-CMU Roybal Center on Behavioral Economics and Health, The LDI Center for Health Incentives, and Alzheimer's Disease Center, 3401 Market Street, Suite 320, Philadelphia, PA 19104, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Karlawish
authors.affiliation: Department of Medicine, University of Pennsylvania School of Medicine, 3400 Civic Center Boulevard, Building 421, Philadelphia, PA 19104, USA.
authors.forename: Judy A
authors.initials: JA
authors.lastname: Shea
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, 330 S. 9th St., Philadelphia, PA 19107, USA.
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.affiliation: Department of Psychiatry, University of Pennsylvania School of Medicine, 3615 Chestnut St., #330, Philadelphia, PA 19104, USA; Department of Neurology, University of Pennsylvania School of Medicine, 330 S. 9th St., Philadelphia, PA 19107, USA; Philadelphia Veterans Affairs Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA. Electronic address: daniel.weintraub@uphs.upenn.edu.
authors.forename: Daniel
authors.initials: D
authors.lastname: Weintraub
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000150:complications* / Q000523:psychology; D011594:Psychometrics / Q000379:methods*; D011795:Surveys and Questionnaires
keywords: Cognition; Instrumental activities of daily living; Parkinson's disease