title: [Predictive factors for bone metastases of prostate cancer].
abstract: OBJECTIVE
  To investigate the correlation between a diverse of clinical factors and bone metastases of prostate cancer.
  
  
  METHODS
  The clinical data of 80 patients with prostate cancer were collected and analyzed. The correlations of age, alkaline phosphotase (ALP), prostate specific antigen (PSA), erythrocyte sedimentation rate (ESR), Gleason score, and expressions of androgen receptor (AR) and Ki-67 with bone metastases were analyzed by one-way ANOVA and Logistic regression analysis. The cutoff value, sensitivity and specificity of the independent correlation factors were calculated.
  
  
  RESULTS
  Forty-five of the 80 patients (56%) were found to have bone metastasis, who had significantly older age and higher levels of ALP, PSA, ESR, Gleason score, and expressions of AR and Ki-67 than those without bone metastasis (P<0.05). Logistic regression analysis identified PSA, Gleason score and AR expression as independent factors correlated with bone metastasis with OR (95% CI) of 1.005 (1.001, 1.009) (P=0.008), 5.356 (1.431, 20.039) (P=0.013), and 18.594 (2.460, 140.524) (P=0.005), respectively. The cutoff values of PSA, Gleason Score and AR were 67.1 ng/ml, 7.5, and 2.5, respectively; their sensitivities were 55.6%, 75.6%, and 84.0% for predicting bone metastasis with specificities of 97.1%, 82.9%, and 91.4%, respectively.
  
  
  CONCLUSIONS
  Of the factors analyzed, PSA, Gleason score and AR expression, but not age, ALP, PSA, ESR, or Ki-67 expression, are the predictive factors of bone metastasis of prostate cancer.
authors.affiliation: Department of Urology, Guangzhou First People's Hospital Affiliated to Guangzhou Medical University, Guangzhou 510180, China. E-mail: chenyehui@gzhmu.edu.cn.
authors.forename: Ye-Hui
authors.initials: YH
authors.lastname: Chen
authors.forename: Pin
authors.initials: P
authors.lastname: Nie
authors.forename: Wen
authors.initials: W
authors.lastname: Jiang
authors.forename: Shi-Jia
authors.initials: SJ
authors.lastname: Zhao
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhang
authors.forename: Hua-Xin
authors.initials: HX
authors.lastname: Lin
authors.forename: Miao-Yuan
authors.initials: MY
authors.lastname: Li
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Liu
authors.forename: Peng-Hui
authors.initials: PH
authors.lastname: Li
authors.forename: Xu-Sheng
authors.initials: XS
authors.lastname: Zhu
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000473:pathology*; D011944:Receptors, Androgen / Q000378:metabolism; D012680:Sensitivity and Specificity
chemical_list: C410798:AR protein, human; D011944:Receptors, Androgen; D000469:Alkaline Phosphatase; D017430:Prostate-Specific Antigen