title: Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives.
abstract: (-)-Cubebin, isolated from the seeds of Piper cubeba, and its five different types of derivatives (a total of 17), with varying functionalities, were tested for their in vitro anticancer activity against six human cancer cell lines (A549, K562, SiHa, KB, HCT116 and HT29) using MTT assay. Cubebin as well as its derivatives containing lactone and amide groups showed significant anticancer activity. In some of the tested cell lines, the amide derivatives showed higher activity. Morphological analysis indicated that these compounds act through apoptosis mediated pathway of cell death and we expect that these results will pave new paths in the development of novel anticancer agents by the derivatization of (-)-cubebin.
authors.affiliation: Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Thiruvananthapuram 695019, Kerala, India.
authors.forename: Dhanya S
authors.initials: DS
authors.lastname: Rajalekshmi
authors.affiliation: Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
authors.forename: Farha A
authors.initials: FA
authors.lastname: Kabeer
authors.affiliation: Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.
authors.forename: Arya R
authors.initials: AR
authors.lastname: Madhusoodhanan
authors.affiliation: Agroprocessing and Natural Products Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Bahulayan
authors.affiliation: Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
authors.forename: Remani
authors.initials: R
authors.lastname: Prathapan
authors.affiliation: Agroprocessing and Natural Products Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.
authors.forename: Nisha
authors.initials: N
authors.lastname: Prakasan
authors.affiliation: Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Varughese
authors.affiliation: Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Thiruvananthapuram 695019, Kerala, India. Electronic address: msn555in@yahoo.co.in.
authors.forename: Mangalam S
authors.initials: MS
authors.lastname: Nair
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D031701:Piper / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; C433065:cubebin
keywords: Amide derivatives; Anticancer activity; Apoptosis; Cubebin; Hinokinin; Morphological analysis