title: Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species.
abstract: Achromobacter spp. are emerging respiratory pathogens in cystic fibrosis patients. Since 2013 the genus Achromobacter includes 15 species for which innate antibiotic resistance is unknown. Previously the AxyXY-OprZ efflux system has been described to confer aminoglycoside (AG) resistance in A. xylosoxidans. Nevertheless, some Achromobacter spp. strains are susceptible to AG. This study including 49 Achromobacter isolates reveals that AG resistance is correlated with different Achromobacter spp. It is noteworthy that the axyXY-oprZ operon is detected only in AG-resistant species, including the most frequently encountered in cystic fibrosis patients: A. xylosoxidans, A. ruhlandii, A. dolens and A. insuavis.
authors.affiliation: Department of Bacteriology, University Hospital of Dijon, Dijon, France.
authors.forename: J
authors.initials: J
authors.lastname: Bador
authors.affiliation: Department of Bacteriology, University Hospital of Dijon, Dijon, France.
authors.forename: C
authors.initials: C
authors.lastname: Neuwirth
authors.affiliation: Department of Bacteriology, University Hospital of Dijon, Dijon, France.
authors.forename: P
authors.initials: P
authors.lastname: Liszczynski
authors.affiliation: Department of Bacteriology, University Hospital of Dijon, Dijon, France.
authors.forename: M-C
authors.initials: MC
authors.lastname: Mézier
authors.affiliation: Department of Bacteriology, University Hospital of Dijon, Dijon, France.
authors.forename: M
authors.initials: M
authors.lastname: Chrétiennot
authors.affiliation: Department of Bacteriology, University Hospital of Dijon, Dijon, France.
authors.forename: E
authors.initials: E
authors.lastname: Grenot
authors.affiliation: Department of Bacteriology, University Hospital of Dijon, Dijon, France.
authors.forename: A
authors.initials: A
authors.lastname: Chapuis
authors.affiliation: Department of Bacteriology, University Hospital of Dijon, Dijon, France.
authors.forename: C
authors.initials: C
authors.lastname: de Curraize
authors.affiliation: Department of Bacteriology, University Hospital of Dijon, Dijon, France.
authors.forename: L
authors.initials: L
authors.lastname: Amoureux
keywords: Achromobacter; AxyXY-OprZ; aminoglycoside resistance; cystic fibrosis; nrdA; selection pressure