title: Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V.
abstract: This report highlights the discovery of a new polymorph of the anticonvulsant drug phenobarbital (PB) using polymer-induced heteronucleation (PIHn) and unravelling the crystal structure of the elusive form V. Both forms are characterized by structural, thermal and VT-Raman spectroscopy methods to elucidate phase transformation behavior and shed light on stability relationships.
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA. Matzger@umich.edu.
authors.forename: Saikat
authors.initials: S
authors.lastname: Roy
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA. Matzger@umich.edu.
authors.forename: N Rajesh
authors.initials: NR
authors.lastname: Goud
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA. Matzger@umich.edu and Macromolecular Science and Engineering, University of Michigan, 48109-1055, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Matzger
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D006801:Humans; D006860:Hydrogen Bonding; D010634:Phenobarbital / Q000737:chemistry / Q000494:pharmacology*; D011110:Polymorphism, Genetic; D013059:Spectrum Analysis, Raman
chemical_list: D010634:Phenobarbital