title: Effectiveness of ultrasound treatment applied with exercise therapy on patients with ankylosing spondylitis: a double-blind, randomized, placebo-controlled trial.
abstract: The aim of our study was to evaluate effectiveness of ultrasound treatment applied with exercise therapy in patients with ankylosing spondylitis. Fifty-two patients, who were diagnosed according to modified New York criteria, were aged 25-60, and have spine pain, were randomly assigned to two groups. Ultrasound (US) and exercise therapy were applied to treatment group (27); placebo US treatment and exercise therapy were applied to control group (25). Patients were evaluated before treatment, at the end of treatment, and 4 weeks after the treatment. Daily and night pain, morning stiffness, patient global assessment (PGA), doctor global assessment (DGA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire, Ankylosing Spondylitis Disease Activity Score (ASDAS) erythrocyte sedimentation rate (ESR), and ASDAS C-reactive protein (CRP) were used as clinical parameters. In US group, all parameters showed significant improvements at 2 and 6 weeks, in comparison with the baseline. In placebo US group, significant improvement was obtained for all parameters (except tragus-to-wall distance and modified Schober test at 2 weeks and lumbar side flexion and modified Schober test at 6 weeks). Comparison of the groups showed significantly superior results of US group for parameters of BASMI (p < 0.05), tragus-wall distance (p < 0.05), PGA (p < 0.01), and DGA (p < 0.05) at 2 weeks as well as for the parameters of daily pain (p < 0.01), PGA (p < 0.05), DGA (p < 0.01), BASDAI (p < 0.05), ASDAS-CRP (p < 0.05), ASDAS-ESR (p < 0.01), lumbar side flexion (p < 0.01), the modified Schober test (p < 0.01), and ASQoL (p < 0.05) at 6 weeks. Our study showed that ultrasound treatment increases the effect of exercise in patients with ankylosing spondylitis.
authors.affiliation: Sultanbeyli State Hospital, Istanbul, Turkey. drduygusilte@hotmail.com.
authors.forename: Duygu
authors.initials: D
authors.lastname: Şilte Karamanlioğlu
authors.affiliation: Fatih Sultan Mehmet Education and Training Hospital, Istanbul, Turkey.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Aktas
authors.affiliation: Fatih Sultan Mehmet Education and Training Hospital, Istanbul, Turkey.
authors.forename: Feyza Unlu
authors.initials: FU
authors.lastname: Ozkan
authors.affiliation: Fatih Sultan Mehmet Education and Training Hospital, Istanbul, Turkey.
authors.forename: Meryem
authors.initials: M
authors.lastname: Kaysin
authors.affiliation: Fatih Sultan Mehmet Education and Training Hospital, Istanbul, Turkey.
authors.forename: Nuray
authors.initials: N
authors.lastname: Girgin
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000628:therapy*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
keywords: Ankylosing spondylitis; Exercise; Ultrasound treatment