title: Robust ultrasensitive tunneling-FET biosensor for point-of-care diagnostics.
abstract: For point-of-care (POC) applications, robust, ultrasensitive, small, rapid, low-power, and low-cost sensors are highly desirable. Here, we present a novel biosensor based on a complementary metal oxide semiconductor (CMOS)-compatible silicon nanowire tunneling field-effect transistor (SiNW-TFET). They were fabricated "top-down" with a low-cost anisotropic self-stop etching technique. Notably, the SiNW-TFET device provided strong anti-interference capacity by applying the inherent ambipolarity via both pH and CYFRA21-1 sensing. This offered a more robust and portable general protocol. The specific label-free detection of CYFRA21-1 down to 0.5 fgml(-1) or ~12.5 aM was achieved using a highly responsive SiNW-TFET device with a minimum sub-threshold slope (SS) of 37 mVdec(-1). Furthermore, real-time measurements highlighted the ability to use clinically relevant samples such as serum. The developed high performance diagnostic system is expected to provide a generic platform for numerous POC applications.
authors.affiliation: Science and Technology on Micro-system Laboratory, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Anran
authors.initials: A
authors.lastname: Gao
authors.affiliation: Science and Technology on Micro-system Laboratory, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Na
authors.initials: N
authors.lastname: Lu
authors.affiliation: Science and Technology on Micro-system Laboratory, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Yuelin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Science and Technology on Micro-system Laboratory, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Tie
authors.initials: T
authors.lastname: Li
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis; D015374:Biosensing Techniques; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053539:Keratin-19 / Q000032:analysis; D053770:Nanowires; D019095:Point-of-Care Systems; D012666:Semiconductors; D012680:Sensitivity and Specificity
chemical_list: D000951:Antigens, Neoplasm; D053539:Keratin-19; C102012:antigen CYFRA21.1