title: Frameless LINAC-based stereotactic radiation therapy to brain metastasis resection cavity without whole-brain radiation therapy: A systematic review.
abstract: OBJECTIVE
  The aim of this systematic review was to summarize the findings from the published data of frameless stereotactic radiation therapy (RT) to the resection cavity delivered with nonrobotic linear accelerator in patients with brain metastases.
  
  
  METHODS
  The studies cited in this systematic review were identified through a search of the PubMed database, using the search terms: "stereotactic [Title/Abstract]" and "Brain [Title/Abstract]," and "Metas* [Title/Abstract]." The search was unlimited to language and publication year.
  
  
  RESULTS
  A total of 9 studies were included in our review. Stereotactic RT to the resection cavity appears to provide excellent local control rates that are comparable to framed stereotactic RT. There are various factors that influence local control. Distant intracranial control rates are poor with the use of postoperative stereotactic RT compared with local treatment (surgery or stereotactic RT) plus whole-brain RT.
  
  
  CONCLUSIONS
  Stereotactic RT to the resection cavity appears to provide good local control rates and poor distant intracranial control. Postoperative treatment should be discussed by a multidisciplinary team and tailored to each case individually.
authors.affiliation: Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina. Electronic address: orit_person@yahoo.com.
authors.forename: Orit
authors.initials: O
authors.lastname: Kaidar-Person
authors.affiliation: Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina; Department of Neurosurgery, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Zagar
authors.affiliation: Department of Neurosurgery, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Matthew
authors.initials: M
authors.lastname: Ewend
authors.affiliation: Division of Oncology & Neuro-Oncology unit Rambam Health Care Campus, Haifa, Israel.
authors.forename: Tzahala
authors.initials: T
authors.lastname: Tzuk-Shina
authors.affiliation: Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Marks
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010315:Particle Accelerators / Q000295:instrumentation*; D016896:Treatment Outcome; D055815:Young Adult