title: Ethnic counts on mortality, New Zealand Cancer Registry and census data: 2006-2011.
abstract: OBJECTIVE
  To investigate the effects on lung function of IV magnesium in acute exacerbations of COPD (AECOPD), when given in conjunction with standard bronchodilator therapy.
  
  
  METHODS
  This was a pilot study to a randomised, double-blinded, placebo-controlled trial. 30 patients presenting to ED with AECOPD were included. In addition to standard bronchodilator therapy, 17 patients were given saline, and 13 received 2 g of magnesium sulphate intravenously. Spirometry was carried out at presentation (TA), after initial standard bronchodilator therapy (TB) and immediately (T0), at 60 minutes (T60) and 120 minutes (T120) after trial drug infusion. Primary outcomes were percentage change in FEV1 and FVC at T0, T60 and T120. Secondary outcomes were admission rates, length of stay and requirement for NIV or mechanical ventilation. Trial registration (ANZCTR), ACTRN12613000837729.
  
  
  RESULTS
  Greater improvements were seen in FEV1 at T0, T60 and T120 compared to TB in magnesium group (at T120, mean percentage change in FEV1 was 27.07% with magnesium versus 11.39% in the placebo group, 95%CI 3.7 to 27.7, p=0.01). Similar significantly greater improvements were noted with FVC in the magnesium group, compared to TB.
  
  
  CONCLUSIONS
  IV magnesium sulphate used as an adjunct therapy to standard bronchodilators in AECOPD presenting to ED may improve lung function in the short term.
authors.forename: Matt
authors.initials: M
authors.lastname: Boyd
authors.affiliation: Department of Public Health University of Otago, Wellington, PO Box 7343, Wellington 6242, New Zealand. tony.blakely@otago.ac.nz.
authors.forename: Tony
authors.initials: T
authors.lastname: Blakely
authors.forename: June
authors.initials: J
authors.lastname: Atkinson
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D019352:Censuses; D002648:Child; D002675:Child, Preschool; D000068598:Data Accuracy; D005260:Female; D054624:Health Status Disparities; D054625:Healthcare Disparities / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000208:ethnology / Q000401:mortality*; D009520:New Zealand / Q000453:epidemiology; D012042:Registries; D017678:Sex Distribution; D055815:Young Adult