title: A Prospective, Matched Comparison Study of SUV Measurements From Time-of-Flight Versus Non-Time-of-Flight PET/CT Scanners.
abstract: OBJECTIVE
  As quantitative F-FDG PET numbers and pooling of results from different PET/CT scanners become more influential in the management of patients, it becomes imperative that we fully interrogate differences between scanners to fully understand the degree of scanner bias on the statistical power of studies.
  
  
  METHODS
  Participants with body mass index (BMI) greater than 25, scheduled on a time-of-flight (TOF)-capable PET/CT scanner, had a consecutive scan on a non-TOF-capable PET/CT scanner and vice versa. SUVmean in various tissues and SUVmax of malignant lesions were measured from both scans, matched to each subject. Data were analyzed using a mixed-effects model, and statistical significance was determined using equivalence testing, with P < 0.05 being significant.
  
  
  RESULTS
  Equivalence was established in all baseline organs, except the cerebellum, matched per patient between scanner types. Mixed-effects method analysis of lesions, repeated between scan types and matched per patient, demonstrated good concordance between scanner types.
  
  
  CONCLUSIONS
  Patients could be scanned on either a TOF or non-TOF-capable PET/CT scanner without clinical compromise to quantitative SUV measurements.
authors.affiliation: From the *Division of Nuclear Medicine and Molecular Imaging, and †Department of Radiation Oncology, Stanford University, Stanford, CA.
authors.forename: Holly M
authors.initials: HM
authors.lastname: Thompson
authors.forename: Ryogo
authors.initials: R
authors.lastname: Minamimoto
authors.forename: Mehran
authors.initials: M
authors.lastname: Jamali
authors.forename: Amir
authors.initials: A
authors.lastname: Barkhodari
authors.forename: Rie
authors.initials: R
authors.lastname: von Eyben
authors.forename: Andrei
authors.initials: A
authors.lastname: Iagaru
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography / Q000295:instrumentation* / Q000379:methods / Q000592:standards; D011446:Prospective Studies; D015203:Reproducibility of Results