title: Cancer: The Transforming Power of Cell Competition.
abstract: The tumour-host microenvironment plays key roles in cancer, but the mechanisms involved are not fully understood. Two new studies provide insight into this problem by showing that through cell competition, a fitness-sensing process that usually eliminates defective cells, pre-cancerous lesions signal the death of surrounding tissue that in turn promotes their neoplastic transformation.
authors.affiliation: MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic address: jesus.gil@csc.mrc.ac.uk.
authors.forename: Jesus
authors.initials: J
authors.lastname: Gil
authors.affiliation: BHF Centre for Research excellence, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic address: tristan.rodriguez@imperial.ac.uk.
authors.forename: Tristan
authors.initials: T
authors.lastname: Rodriguez
mesh_terms: D002471:Cell Transformation, Neoplastic; D006801:Humans; D009369:Neoplasms; D059016:Tumor Microenvironment