title: Magnesium ring device to restore function of a transected anterior cruciate ligament in the goat stifle joint.
abstract: A bioresorbable, mono-crystalline magnesium (Mg) ring device and suture implantation technique were designed to connect the ends of a transected anterior cruciate ligament (ACL) to restabilize the knee and load the ACL to prevent disuse atrophy of its insertion sites and facilitate its healing. To test its application, cadaveric goat stifle joints were evaluated using a robotic/universal force-moment sensor testing system in three states: Intact, ACL-deficient, and after Mg ring repair, at 30°, 60°, and 90° of joint flexion. Under a 67-N anterior tibial load simulating that used in clinical examinations, the corresponding anterior tibial translation (ATT) and in-situ forces in the ACL and medial meniscus for 0 and 100 N of axial compression were obtained and compared with a control group treated with suture repair. In all cases, Mg ring repair reduced the ATT by over 50% compared to the ACL-deficient joint, and in-situ forces in the ACL and medial meniscus were restored to near normal levels, showing significant improvement over suture repair. These findings suggest that Mg ring repair could successfully stabilize the joint and load the ACL immediately after surgery, laying the framework for future in vivo studies to assess its utility for ACL healing. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:2001-2008, 2016.
authors.affiliation: Department of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
authors.forename: Kathryn F
authors.initials: KF
authors.lastname: Farraro
authors.affiliation: Department of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Sasaki
authors.affiliation: Department of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
authors.forename: Savio L-Y
authors.initials: SL
authors.lastname: Woo
authors.affiliation: Department of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
authors.forename: Kwang E
authors.initials: KE
authors.lastname: Kim
authors.affiliation: Department of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
authors.forename: Matteo M
authors.initials: MM
authors.lastname: Tei
authors.affiliation: Department of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
authors.forename: Andrea
authors.initials: A
authors.lastname: Speziali
authors.affiliation: Department of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: McMahon
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D000070598:Anterior Cruciate Ligament Injuries / Q000601:surgery*; D059549:Anterior Cruciate Ligament Reconstruction / Q000295:instrumentation* / Q000379:methods; D006041:Goats; D008274:Magnesium; D013536:Suture Techniques
chemical_list: D008274:Magnesium
keywords: ACL repair; anterior cruciate ligament (ACL); magnesium ring device; robotic testing system