title: Infections and neutrophils in the pathogenesis of bronchiolitis obliterans syndrome in children after allogeneic stem cell transplantation.
abstract: It is plausible that infections post-hematopoietic SCT play a role in the pathogenesis of BOS. A prospective study for children with history, questionnaire, examination, PFTs, and blood counts at one, three, six, nine, 12, 18, and 24 months post-SCT was conducted. Between September 2009 and September 2011 (n = 39), six developed BOS at 200 days (range 94-282), three patients had probable clinical respiratory infection, and all six had higher neutrophil count compared to non-BOS patients (4.7 vs. 2.4 at three months and 6.3 vs. 2.9 at six months ×10(9) /L, p = 0.03). Contribution of clinical and subclinical infection needs to be considered in the pathogenesis of BOS.
authors.affiliation: Division of Haematology/Oncology/BMT, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Adam
authors.initials: A
authors.lastname: Gassas
authors.affiliation: Division of Haematology/Oncology/BMT, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Joerg
authors.initials: J
authors.lastname: Krueger
authors.affiliation: Division of Hematology/Oncology/BMT, Rambam Medical Center, Haifa, Israel.
authors.forename: Irina
authors.initials: I
authors.lastname: Zaidman
authors.affiliation: Division of Haematology/Oncology/BMT, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Tal
authors.initials: T
authors.lastname: Schechter
authors.affiliation: Programs of Physiology & Experimental Medicine, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.|Department of Laboratory Medicine and Pathobiology, and Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
authors.forename: Hayley
authors.initials: H
authors.lastname: Craig-Barnes
authors.affiliation: Division of Haematology/Oncology/BMT, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ali
authors.affiliation: Programs of Physiology & Experimental Medicine, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.|Department of Laboratory Medicine and Pathobiology, and Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
authors.forename: Nades
authors.initials: N
authors.lastname: Palaniyar
mesh_terms: D000293:Adolescent; D001989:Bronchiolitis Obliterans / Q000209:etiology* / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007239:Infections / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000276:immunology*; D011446:Prospective Studies; D012129:Respiratory Function Tests; D012141:Respiratory Tract Infections / Q000209:etiology / Q000276:immunology / Q000628:therapy; D013997:Time Factors; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D016896:Treatment Outcome
keywords: allogeneic SCT; bronchiolitis obliterans syndrome; children; infection; neutrophils