title: The Chemical Diversity of Lantana camara: Analyses of Essential Oil Samples from Cuba, Nepal, and Yemen.
abstract: The aerial parts of Lantana camara L. were collected from three different geographical locations: Artemisa (Cuba), Biratnagar (Nepal), and Sana'a (Yemen). The essential oils were obtained by hydrodistillation and analyzed by gas chromatography/mass spectrometry. A cluster analysis of 39 L. camara essential oil compositions revealed eight major chemotypes: β-caryophyllene, germacrene D, ar-curcumene/zingiberene, γ-curcumen-15-al/epi-β-bisabolol, (E)-nerolidol, davanone, eugenol/alloaromadendrene, and carvone. The sample from Cuba falls into the group dominated by (E)-nerolidol, the sample from Nepal is a davanone chemotype, and the sample from Yemen belongs to the β-caryophyllene chemotype. The chemical composition of L. camara oil plays a role in the biological activity; the β-caryophyllene and (E)-nerolidol chemotypes showed antimicrobial and cytotoxic activities.
authors.affiliation: Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, 35899, USA.
authors.forename: Prabodh
authors.initials: P
authors.lastname: Satyal
authors.affiliation: Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, 35899, USA.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Crouch
authors.affiliation: Parasitology Department, Institute of Tropical Medicine 'Pedro Kouri', 10400, Havana, Cuba.
authors.forename: Lianet
authors.initials: L
authors.lastname: Monzote
authors.affiliation: Laboratory for Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Universiteitsplein 1, B-2610, Antwerp, Belgium.
authors.forename: Paul
authors.initials: P
authors.lastname: Cos
authors.affiliation: Pharmacognosy Department, Faculty of Clinical Pharmacy, Albaha University, Al Baha, Kingdom of Saudi Arabia.|Pharmacognosy Department, Faculty of Pharmacy, Sana'a University, P.O. Box 13150, Sana'a, Yemen.
authors.forename: Nasser A
authors.initials: NA
authors.lastname: Awadh Ali
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, Aden University, Aden, Yemen.
authors.forename: Mehdi A
authors.initials: MA
authors.lastname: Alhaj
authors.affiliation: Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, 35899, USA.
authors.forename: William N
authors.initials: WN
authors.lastname: Setzer
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003462:Cuba; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D032410:Lantana / Q000737:chemistry*; D061986:MCF-7 Cells; D008826:Microbial Sensitivity Tests; D009390:Nepal; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D015006:Yemen
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile
keywords: Antimicrobial activity; Chemotaxonomy; Cluster analysis; Cytotoxic activity; Essential oils