title: Enhancing binding affinity and selectivity through preorganization and cooperative enhancement of the receptor.
abstract: When direct host-guest binding interactions are weakened by unfavorable solvent competition, guest-triggered intrareceptor interactions could be used to augment the binding. This strategy of cooperative enhancement, when combined with the principle of preorganization, yielded a strong and selective receptor for binding citrate in water.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111, USA. zhaoy@iastate.edu.
authors.forename: Roshan W
authors.initials: RW
authors.lastname: Gunasekara
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111, USA. zhaoy@iastate.edu.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao