title: Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles.
abstract: A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium- and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl compounds. The structure of 3-(2H-indazol-2-yl)-2H-chromen-2-one was proven by X-ray crystallography. The styrene- and coumarin-2H-indazoles produced by using the new method were found to have interesting fluorescence properties.
authors.affiliation: Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan. mhlin@cc.ncue.edu.tw.
authors.forename: Mei-Huey
authors.initials: MH
authors.lastname: Lin
authors.affiliation: Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan. k7731379@livemail.tw.
authors.forename: Kung-Yu
authors.initials: KY
authors.lastname: Liang
authors.affiliation: Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan. blueangela39@gmail.com.
authors.forename: Chang-Hsien
authors.initials: CH
authors.lastname: Tsai
authors.affiliation: Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan. stu01250008@gmail.com.
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan. j2261102002@hotmail.com.
authors.forename: Hung-Chang
authors.initials: HC
authors.lastname: Hsiao
authors.affiliation: Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan. jere035330@hotmail.com.
authors.forename: Yi-Syuan
authors.initials: YS
authors.lastname: Li
authors.affiliation: Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan. zx25610548zx25610548@yahoo.com.tw.
authors.forename: Chung-Hao
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan. smile3156@gmail.com.
authors.forename: Hau-Chun
authors.initials: HC
authors.lastname: Wu
mesh_terms: D000478:Alkylation; D002384:Catalysis; D018360:Crystallography, X-Ray; D007191:Indazoles / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D007191:Indazoles
keywords: coumarin; fluorescence; indazoles; regioselective alkylation; styrene