title: Synthesis and Characterization of Some New Coumarins with in Vitro Antitumor and Antioxidant Activity and High Protective Effects against DNA Damage.
abstract: Coumarins are naturally occurring oxygen heterocyclic compounds having multifarious medicinal properties, hence used as lead compounds for designing new potent analogs. The chromene butenoic acid 3 and the benzochromene butenoic acid 4 which are derived from the reaction of glyoxalic acid with 3-acetylcoumarin and 3-acetylbenzocoumarin, respectively, were reacted with different nitrogen and carbon nucleophiles to give new heterocyclic compounds. The structures of the prepared compounds were elucidated by IR, ¹H-NMR, and mass spectroscopy. Some of the newly prepared compounds were tested in vitro against a panel of four human tumor cell lines namely; hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, human prostate cancer PC3, and mammary gland breast MCF-7. Also they were tested as antioxidants. Almost all of the tested compounds showed satisfactory activity.
authors.affiliation: Synthetic Organic Chemistry Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Abassia, Cairo 11566, Egypt. salemmai1947@yahoo.com.
authors.forename: Mounir A I
authors.initials: MA
authors.lastname: Salem
authors.affiliation: Synthetic Organic Chemistry Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Abassia, Cairo 11566, Egypt. magda_marzouk@sci.asu.edu.eg.
authors.forename: Magda I
authors.initials: MI
authors.lastname: Marzouk
authors.affiliation: Faculty of Education; Ain Shams University, Roxy, Cairo 11711, Egypt. az_azelkazak@hotmail.com.
authors.forename: Azza M
authors.initials: AM
authors.lastname: El-Kazak
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D001578:Benzopyrans / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D004249:DNA Damage / Q000187:drug effects; D006038:Glyoxylates / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010084:Oxidation-Reduction; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001578:Benzopyrans; D003374:Coumarins; D006038:Glyoxylates; C031150:glyoxylic acid
keywords: antioxidant activity; antitumor activity; functionalized coumarin