title: Regulation of Monoclonal Antibody Immunotherapy by FcγRIIB.
abstract: Monoclonal antibodies (mAb) are revolutionising the treatment of many different diseases. Given their differing mode of action compared to most conventional chemotherapeutics and small molecule inhibitors, they possess the potential to be independent of common modes of treatment resistance and can typically be combined readily with existing treatments without dose-limiting toxicity. However, treatments with mAb rarely result in cure and so a full understanding of how these reagents work and can be optimised is key for their subsequent improvement. Here we review how an understanding of the biology of the inhibitory Fc receptor, FcγRIIB (CD32B), is leading to the development of improved mAb treatments.
authors.affiliation: Antibody & Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Stopforth
authors.affiliation: Antibody & Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.
authors.forename: Kirstie L S
authors.initials: KL
authors.lastname: Cleary
authors.affiliation: Antibody & Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK. msc@soton.ac.uk.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Cragg
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D000920:Antibody-Dependent Cell Cytotoxicity / Q000235:genetics / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000276:immunology / Q000378:metabolism; D018951:Antigens, CD20 / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007109:Immunity; D007074:Immunoglobulin G / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D056747:Immunomodulation; D007167:Immunotherapy / Q000379:methods; D011485:Protein Binding; D015202:Protein Engineering; D017452:Receptors, IgG / Q000235:genetics / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D018951:Antigens, CD20; C080571:Fc gamma receptor IIB; D007074:Immunoglobulin G; D017452:Receptors, IgG
keywords: CD32B; FcγRIIB; Monoclonal antibody; antigenic modulation; immunomodulation; immunotherapy