title: What Have We Learned From Brain Functional Connectivity Studies in Migraine Headache?
abstract: Over the past 20 years, headache syndromes, especially migraine, have benefited significantly from the knowledge gained through neuroimaging studies. This article is focused on the neuroimaging studies of the functional organization and connectivity of the migraine brain. First, data sources and the study design elements in functional neuroimaging studies of the brain connectivity in migraine headaches are discussed. Then, the article reviews the findings to date and discusses how functional connectivity studies have contributed to a better understanding of the mechanisms of the migraine disease by extending the focus from a single region or structure to a network of regions and structures and the interactions among them. Finally, the potential scenarios for the translation of connectivity knowledge to the benefit for patients are discussed.
authors.affiliation: Psychiatric Neuroimaging Division, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Nasim
authors.initials: N
authors.lastname: Maleki
authors.affiliation: Psychiatric Neuroimaging Division, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.|Department of Radiology, A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Randy L
authors.initials: RL
authors.lastname: Gollub
mesh_terms: D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D059907:Functional Neuroimaging; D006801:Humans; D008881:Migraine Disorders / Q000503:physiopathology*
keywords: functional connectivity; functional magnetic resonance imaging; migraine; regional homogeneity; resting state networks