title: Preparation of a Novel Form of Gelatin With a Three-Dimensional Ordered Macroporous Structure to Regulate the Release of Poorly Water-Soluble Drugs.
abstract: In this study, a novel three-dimensional ordered macroporous gelatin (3DOMG) was fabricated as a carrier for increasing the solubility of poorly water-soluble drugs, offering sustained release and a high oral bioavailability. Polymethyl methacrylate nanospheres (257 nm) were used as a colloidal plastic framework to synthesize 3DOMG. Fenofibrate (FNB) was selected as a model drug and loaded onto 3DOMG by the adsorption equilibrium method. Detailed characterization showed that the FNB absorbed onto 3DOMG was in a microcrystalline state. A fluorescence experiment and the prepared drug microcrystal network gave further information on the physical state of the drug. A degradation experiment proved that 3DOMG was readily biodegradable. In vitro release testing showed that 3DOMG increased the dissolution rate of FNB and produced a sustained release. An in vivo pharmacokinetic study confirmed that 3DOMG improved the oral bioavailability compared with that of commercial sustained-release capsules. These findings confirm that 3DOMG can be regarded as a promising carrier for an oral drug delivery system.
authors.affiliation: Pharmacy School, Liaoning Medical University, 40 Songpo Road, Linghe District, Jinzhou, Liaoning Province 121000, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.affiliation: Pharmacy School, Liaoning Medical University, 40 Songpo Road, Linghe District, Jinzhou, Liaoning Province 121000, China.
authors.forename: Zongzhe
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Pharmacy School, Liaoning Medical University, 40 Songpo Road, Linghe District, Jinzhou, Liaoning Province 121000, China.
authors.forename: Yanna
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Pharmacy School, Liaoning Medical University, 40 Songpo Road, Linghe District, Jinzhou, Liaoning Province 121000, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Pharmacy School, Liaoning Medical University, 40 Songpo Road, Linghe District, Jinzhou, Liaoning Province 121000, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Pharmacy School, Liaoning Medical University, 40 Songpo Road, Linghe District, Jinzhou, Liaoning Province 121000, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Pharmacy School, Liaoning Medical University, 40 Songpo Road, Linghe District, Jinzhou, Liaoning Province 121000, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Yu
authors.affiliation: Pharmacy School, Liaoning Medical University, 40 Songpo Road, Linghe District, Jinzhou, Liaoning Province 121000, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Ji
authors.affiliation: Pharmacy School, Liaoning Medical University, 40 Songpo Road, Linghe District, Jinzhou, Liaoning Province 121000, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Pharmacy School, Liaoning Medical University, 40 Songpo Road, Linghe District, Jinzhou, Liaoning Province 121000, China. Electronic address: wuchao27@126.com.
authors.forename: Chao
authors.initials: C
authors.lastname: Wu
mesh_terms: D000818:Animals; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D003102:Colloids; D003692:Delayed-Action Preparations; D005079:Excipients / Q000008:administration & dosage / Q000737:chemistry*; D011345:Fenofibrate / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D005780:Gelatin / Q000008:administration & dosage / Q000737:chemistry*; D054118:Nanospheres; D010316:Particle Size; D019904:Polymethyl Methacrylate; D016062:Porosity; D011817:Rabbits; D012995:Solubility
chemical_list: D002214:Capsules; D003102:Colloids; D003692:Delayed-Action Preparations; D005079:Excipients; D005780:Gelatin; D019904:Polymethyl Methacrylate; D011345:Fenofibrate
keywords: bioavailability; biodegradability; biomaterials; fenofibrate; gelatin; materials science; nanotechnology; polymeric drug carrier; sustained release; three-dimensional ordered macroporous