title: Substantial Increase in Myocardial FDG Uptake on Interim PET/CT May Be an Early Sign of Adriamycin-Induced Cardiotoxicity.
abstract: Cumulative cardiotoxicity is a well-established adverse effect of Adriamycin therapy. Although dose dependent, cardiotoxicity has been recently reported to occur even at lower doses than usually proposed. Conventional imaging detection and/or clinical manifestation of the deterioration in cardiac function occur late in the process; thus, it is desirable to have noninvasive markers to detect toxicity at an early stage. Several biochemical markers including troponin and atrial natriuretic peptide were explored for this purpose. The present case depicts that a significant increase in myocardial FDG uptake on posttherapy PET/CT can be a potential imaging biomarker of Adriamycin-induced cardiotoxicity.
authors.affiliation: From the Departments of *Nuclear Medicine, and †Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Arun Kumar Reddy
authors.initials: AK
authors.lastname: Gorla
authors.forename: Ashwani
authors.initials: A
authors.lastname: Sood
authors.forename: Gaurav
authors.initials: G
authors.lastname: Prakash
authors.forename: Madan
authors.initials: M
authors.lastname: Parmar
authors.forename: Bhagwant Rai
authors.initials: BR
authors.lastname: Mittal
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D066126:Cardiotoxicity / Q000000981:diagnostic imaging / Q000209:etiology; D004317:Doxorubicin / Q000009:adverse effects*; D019788:Fluorodeoxyglucose F18; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals
chemical_list: D000903:Antibiotics, Antineoplastic; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D004317:Doxorubicin