title: Assessment of right ventricular systolic and diastolic parameters in pulmonary sarcoidosis.
abstract: The clinical manifestations of cardiac involvement are seen in about 5% of patients with sarcoidosis; however, the incidence of cardiac involvement is higher in the autopsy series. About 14% of patients with pulmonary sarcoidosis (PS) without known cardiac involvement had diastolic dysfunction.We aimed to determine the role of parameters of right ventricular (RV) systolic and diastolic function in patients with PS without evidence of cardiac symptoms. Our study population consisted of 28 patients with grades 1-4 PS and 24 healthy subjects. This study was a clinical prospective cohort study. RV end-diastolic area was found to be significantly higher in the PS group (p=0.032). RV fractional area change (RVFAC) and tricuspid annular plane systolic excursion (TAPSE) were shown to be statistically lower in the PS group as compared to the control group (p<0.001). However, pulmonary arterial systolic pressure was significantly higher in the PS group (p=0.003). The tricuspid E velocity and E/A ratio were found to be significantly lower in the PS group (p=0.025 and 0.009, respectively), while the tricuspid A velocity and myocardial performance index (MPI) were found to be significantly lower in the control group (p=0.034 and 0.007, respectively). Early detection of cardiac involvement in PS is crucial because of the increased morbidity and risk of sudden cardiac death. RV diastolic Doppler parameters, tissue Doppler MPI, RVFAC and TAPSE are practical and cheap techniques in the diagnosis of cardiac involvement in patients with PS. A thorough transthorasic echocardiographic examination including RV systolic and diastolic functions and tissue Doppler MPI should constitute the mainstay of initial management and follow-up in PS.
authors.affiliation: Department of Cardiology, Erzurum Training and Research Hospital, Erzurum, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Ipek
authors.affiliation: Department of Cardiology, Erzurum Training and Research Hospital, Erzurum, Turkey.
authors.forename: Selami
authors.initials: S
authors.lastname: Demirelli
authors.affiliation: Department of Cardiology, Erzurum Training and Research Hospital, Erzurum, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Ermis
authors.affiliation: Department of Cardiology, Erzurum Training and Research Hospital, Erzurum, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Yıldırım
authors.affiliation: Department of Cardiology, Erzurum Training and Research Hospital, Erzurum, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Öztürk
authors.affiliation: Department of Cardiology, Arel University, Medicana Hospital, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yolcu
authors.affiliation: Department of Pulmonology, Atatürk University School of Medicine, Erzurum, Turkey.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Araz
authors.affiliation: Department of Cardiology, Erzurum Training and Research Hospital, Erzurum, Turkey.
authors.forename: Kamuran
authors.initials: K
authors.lastname: Kalkan
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003971:Diastole / Q000502:physiology*; D015150:Echocardiography, Doppler; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010100:Oxygen / Q000378:metabolism; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013147:Spirometry; D013599:Systole / Q000502:physiology*; D014261:Tricuspid Valve / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D010100:Oxygen
keywords: Echocardiography; Echocardiography, Doppler; Heart Ventricles; Sarcoidosis