title: The association of metabolic syndrome with left ventricular mass and geometry in community-based hypertensive patients among Han Chinese.
abstract: BACKGROUND
  The association of metabolic syndrome (MS) with left ventricular (LV) hypertrophy is controversial. The objective of our study was to investigate the influence of MS on LV mass and geometry in community-based hypertensive patients among Han Chinese.
  
  
  METHODS
  This study included 1733 metabolic syndrome patients according to the International Diabetes Federation (IDF) definition and 2373 non-MS hypertension patients. LV hypertrophy was diagnosed by the criteria of LV mass ≥49.2 g/m(2.7) for men and 46.7 g/m(2.7) for women. LV geometric patterns (normal, concentric remodeling, concentric or eccentric hypertrophy) were calculated according to LV hypertrophy and relative wall thickness. Logistic regression analysis was used to determine odds ratio (OR) and 95% confidence interval (CI) of MS for LV hypertrophy and LV geometry abnormality.
  
  
  RESULTS
  The LV mass and LV mass index were higher in the MS group than in the non-MS group. In multiple adjusted models. LV mass index, LV mass, interventricular septum, and post wall were raised with the increased number of MS disorders. MS was associated with increased LV hypertrophy risk (unadjusted OR 1.38; 95% CI 1.21-1.57); age, sex, and blood pressure (BP; adjusted OR 1.39; 95% CI 1.22-1.59). MS was also associated with increased risk of eccentric hypertrophy in male and female patients. MS was only associated with increased risk of concentric hypertrophy in female patients; and MS was not associated with concentric remodeling.
  
  
  CONCLUSIONS
  LV mass and LV mass index were associated with the increased number of MS disorders in the Chinese community-based hypertensive population. MS was not only associated with increased LV hypertrophy risk, but also associated with concentric and eccentric LV geometry abnormality, especially in females.
authors.affiliation: Department of Cadre Clinic, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Shuxia
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Kangxing
authors.initials: K
authors.lastname: Song
authors.affiliation: Department of Cadre Clinic, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Xiyun
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xue
authors.affiliation: Department of Plastic Surgery, Qingdao Second Nursing Hospital of Ji'nan Military Area Command, Beijing, China.
authors.forename: Nina
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education Cardiovascular Institute, Fuwai Hospital, Beijing Union Medical College, Beijing, China.
authors.forename: Jingzhou
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education Cardiovascular Institute, Fuwai Hospital, Beijing Union Medical College, Beijing, China.
authors.forename: Yubao
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Department of Cardiology, Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education Cardiovascular Institute, Fuwai Hospital, Beijing Union Medical College, Beijing, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.affiliation: Department of Cardiology, Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education Cardiovascular Institute, Fuwai Hospital, Beijing Union Medical College, Beijing, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Cadre Clinic, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Jinggui
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Cardiology, Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education Cardiovascular Institute, Fuwai Hospital, Beijing Union Medical College, Beijing, China.
authors.forename: Rutai
authors.initials: R
authors.lastname: Hui
keywords: Hypertension; LV hypertrophy; left ventricular (LV) geometry abnormality; metabolic syndrome (MS)