title: [Effect of probiotics in prevention and treatment of allergic diseases in children].
abstract: The increasing incidence rate of allergic diseases has attracted global attention, and these diseases greatly threaten children&prime;s health. The common pathogenesis of allergic diseases is the specific IgE- or cell-mediated immune response to common inhalant or food allergens. Epidemiological investigation, analysis of fecal flora, and clinical studies all suggest that the development and progression of allergic diseases are closely related to the early disturbance of intestinal flora. Probiotics can regulate intestinal immune response, increase the barrier function of epithelial cells, inhibit the adhesion and colonization of pathogenic bacteria, and thus restore or reconstruct normal intestinal flora. With the increasing understanding of allergic diseases, the effect of probiotics in the prevention and treatment of such diseases will be taken more and more seriously.
authors.affiliation: Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan 430060, China. lpxia@126.com.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Xia
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D002648:Child; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D019936:Probiotics / Q000008:administration & dosage*