title: Mapping neuroplastic potential in brain-damaged patients.
abstract: It is increasingly acknowledged that the brain is highly plastic. However, the anatomic factors governing the potential for neuroplasticity have hardly been investigated. To bridge this knowledge gap, we generated a probabilistic atlas of functional plasticity derived from both anatomic magnetic resonance imaging results and intraoperative mapping data on 231 patients having undergone surgery for diffuse, low-grade glioma. The atlas includes detailed level of confidence information and is supplemented with a series of comprehensive, connectivity-based cluster analyses. Our results show that cortical plasticity is generally high in the cortex (except in primary unimodal areas and in a small set of neural hubs) and rather low in connective tracts (especially associative and projection tracts). The atlas sheds new light on the topological organization of critical neural systems and may also be useful in predicting the likelihood of recovery (as a function of lesion topology) in various neuropathological conditions-a crucial factor in improving the care of brain-damaged patients.
authors.affiliation: 1 Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, F-34295 Montpellier, France 2 Institute for Neuroscience of Montpellier, INSERM U1051 (Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors research group), Saint Eloi Hospital, Montpellier University Medical Center, F-34091 Montpellier, France guillaume.herbet@gmail.com.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Herbet
authors.affiliation: 3 Départements d'Etudes Cognitives, Ecole Normale Supérieure, F-75005 Paris, France 4 Faculté des Sciences Fondamentales et Biomédicales, Université Paris Descartes, F-75006 Paris, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Maheu
authors.affiliation: 5 Department of Neuroscience, Division of Neurosurgery, University of Brescia, Brescia, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Costi
authors.affiliation: 6 Univ. Lille, EA 4072 - PSITEC - Psychologie: Interactions, Temps, Émotions, Cognition, F-59000 Lille, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Lafargue
authors.affiliation: 1 Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, F-34295 Montpellier, France 2 Institute for Neuroscience of Montpellier, INSERM U1051 (Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors research group), Saint Eloi Hospital, Montpellier University Medical Center, F-34091 Montpellier, France guillaume.herbet@gmail.com.
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000716:Anatomy, Artistic / Q000379:methods*; D001271:Atlases as Topic; D001930:Brain Injuries / Q000175:diagnosis* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity / Q000502:physiology*; D012189:Retrospective Studies; D055815:Young Adult
keywords: brain injury; electrostimulation mapping; glioma; neuroplasticity; white matter connectivity