title: Methanol Induced Toxic Amblyopia--A Case Report.
abstract: A 28-year-old man, smoker having history of occasional alcohol intake--was admitted in the Department of Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU) with gradual diminution of vision in both eyes 10 days after consumption of homemade alcoholic beverage in a wedding ceremony. His initial acuity of vision was limited to no perception of light in right eye and hand movement in left eye. Fundus examination revealed pale optic discs in both eyes. The patient was treated with Injection Methylprednisolone 1000 mg intravenous slowly over 1 hour for 3 consecutive days. This was followed by oral prednisolone 60 mg daily for 14 days and then gradually tapered over 4 weeks. The patient also received Injection Hydroxycobalamine and Injection Folinic Acid for 2 weeks. On the 3rd day of treatment there was perception of light in the right eye and on the 10th day the visual acuity improved to hand movement. In the left eye, the visual acuity gradually improved to 6/60 on 3rd day and on 10th day improved to 6/24. Four weeks later, the visual acuity had recovered in both eyes to 6/18. Combination of intravenous and oral steroid along with vitamin B1 and folinic acid has been found effective in treating severe methanol induced optic neuropathy.
authors.affiliation: Dr Abed Hussain Khan, Medical Officer, Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka, Bangladesh.
authors.forename: A H
authors.initials: AH
authors.lastname: Khan
authors.forename: M F
authors.initials: MF
authors.lastname: Rahaman
authors.forename: R I
authors.initials: RI
authors.lastname: Mollah
authors.forename: A
authors.initials: A
authors.lastname: Alam
authors.forename: S N
authors.initials: SN
authors.lastname: Hassan
authors.forename: M A
authors.initials: MA
authors.lastname: Chowdhury
mesh_terms: D000328:Adult; D000550:Amblyopia / Q000139:chemically induced* / Q000188:drug therapy*; D001459:Bangladesh; D006801:Humans; D008297:Male; D000432:Methanol / Q000506:poisoning*; D008775:Methylprednisolone / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018696:Neuroprotective Agents; D008775:Methylprednisolone; D000432:Methanol