title: Alcoholic Liver Disease in Asia, Europe, and North America.
abstract: Alcoholic liver diseases comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis. Although the relationship between alcohol consumption and liver disease is well established, severe alcohol-related morbidities develop in only a minority of people who consume alcohol in excess. Inter-individual differences in susceptibility to the toxic effects of alcohol have been studied extensively-they include pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. Alcoholic liver disease is becoming more common in many parts of Asia, but is decreasing in Western Europe. Treatment approaches, including availability of medications, models of care, and approach to transplantation, differ among regions.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Roudebush Veterans Administration Medical Center, Indianapolis, Indiana. Electronic address: sliangpu@iupui.edu.
authors.forename: Suthat
authors.initials: S
authors.lastname: Liangpunsakul
authors.affiliation: Drug Health Services, Royal Prince Alfred Hospital, Sydney Medical School, University of Sydney, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Haber
authors.affiliation: Centenary Research Institute, AW Morrow GE/Liver Center Australian Liver Transplant Unit Royal Prince Alfred Hospital, University of Sydney, Australia.
authors.forename: Geoffrey W
authors.initials: GW
authors.lastname: McCaughan
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology*; D001208:Asia / Q000453:epidemiology; D004032:Diet; D005060:Europe / Q000453:epidemiology; D006801:Humans; D008099:Liver / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D009656:North America / Q000453:epidemiology; D012737:Sex Factors
keywords: Alcoholic Liver Disease; Asia; Clinical Profiles; Europe; North America