title: Influence of treadmill training on bone structure under osteometabolic alteration in rats subjected to high-fat diet.
abstract: Nutrition and physical training have important roles in the accumulation and maintenance of bone mass. The aim of this study was to evaluate, in ovariectomized rats (OVX), the effects of treadmill training (T) with high-fat diet (F) on weight gain and bone tissue properties with eight groups (n = 10) for 12 weeks: OVX SC (OVX, sedentary lifestyle, diet control); OVX SF; OVX TC; OVX TF; SH SC (SHAM, sedentary lifestyle, diet control); SH SF; SH TC; and SH TF. Weekly weight gain and final body composition were assessed. After euthanasia, tibiae were analyzed. The trained animals had higher body weight (P = 0.001), bone mineral density (P < 0.001), and trabecular bone (P < 0.001). The animals with a high-fat diet showed higher global fat (P < 0.001), percentage of global fat (P < 0.001) and deformation at impact (P = 0.031) and reduced tibial bone mineral content (P = 0.036). Physical training improves bone microarchitecture, without presenting an increase in impact resistance, and a high-fat diet increases body fat and impairs bone mineralization.
authors.affiliation: Bioengineering Laboratory, Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: A P
authors.initials: AP
authors.lastname: Macedo
authors.affiliation: Bioengineering Laboratory, Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: R C
authors.initials: RC
authors.lastname: Shimano
authors.affiliation: Bioengineering Laboratory, Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: D T
authors.initials: DT
authors.lastname: Ferrari
authors.affiliation: Department of Morphology, Physiology and Basic Pathology, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
authors.forename: J P M
authors.initials: JP
authors.lastname: Issa
authors.affiliation: Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: A A
authors.initials: AA
authors.lastname: Jordão
authors.affiliation: Bioengineering Laboratory, Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: A C
authors.initials: AC
authors.lastname: Shimano
mesh_terms: D000273:Adipose Tissue; D000818:Animals; D001823:Body Composition; D015519:Bone Density; D000071556:Cancellous Bone / Q000473:pathology*; D000071538:Cortical Bone / Q000473:pathology*; D059305:Diet, High-Fat; D005260:Female; D010052:Ovariectomy; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000473:pathology*; D015430:Weight Gain
keywords: Ovariectomy; bone diseases; high-fat diet; metabolic; microscopy; treadmill training