title: Adoptive transferred hepatic stellate cells attenuated drug-induced liver injury by modulating the rate of regulatory T cells/T helper 17 cells.
abstract: Our study showed that hepatic stellate cells (HSCs) promote the healing of the liver after drug-induced acute injury. However, the relevant mechanisms by which this is accomplished remain unclear. The objective of this study was to investigate the role of the adoptive transfer of HSCs in acute liver injury and the underlying mechanisms for healing. It was found that adoptive transfer of HSCs resulted in an increase in Tregs and a decrease in Th17 cells. Liver insult was consistently attenuated by HSC treatment. HSC cultured medium induced Tregs from naive T cells and suppressed the differentiation of Th17 cells. This study demonstrated that the adoptive transfer of HSCs protected the liver from drug-induced acute injury. Promoting the differentiation of Tregs and suppressing the development of Th17 cells are possibly involved in the protective effect of adoptive transfer of HSCs.
authors.affiliation: Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Feng
authors.affiliation: Radiology Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Key Laboratory of Living Donor Liver Transplantation of Ministry of Public Health, Nanjing 210029, China.
authors.forename: Quanrongzi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Key Laboratory of Living Donor Liver Transplantation of Ministry of Public Health, Nanjing 210029, China.
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Key Laboratory of Living Donor Liver Transplantation of Ministry of Public Health, Nanjing 210029, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China. Electronic address: Guan-wx@163.com.
authors.forename: Wenxian
authors.initials: W
authors.lastname: Guan
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D015153:Blotting, Western; D002454:Cell Differentiation; D002478:Cells, Cultured; D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology / Q000628:therapy*; D055166:Hepatic Stellate Cells / Q000637:transplantation*; D051379:Mice; D008810:Mice, Inbred C57BL; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*
keywords: Hepatic stellate cells; Regulatory T cells; T helper 17 cells; Th17 cells; Tregs