title: The Roles of Microtubule-Based Transport at Presynaptic Nerve Terminals.
abstract: Targeted intracellular movement of presynaptic proteins plays important roles during synapse formation and, later, in the homeostatic maintenance of mature synapses. Movement of these proteins, often as vesicular packages, is mediated by motor complexes travelling along intracellular cytoskeletal networks. Presynaptic protein transport by kinesin motors in particular plays important roles during synaptogenesis to bring newly synthesized proteins to establish nascent synaptic sites. Conversely, movement of proteins away from presynaptic sites by Dynein motors enables synapse-nuclear signaling and allows for synaptic renewal through degradation of unwanted or damaged proteins. Remarkably, recent data has indicated that synaptic and protein trafficking machineries can modulate each other's functions. Here, we survey the mechanisms involved in moving presynaptic components to and away from synapses and how this process supports presynaptic function.
authors.affiliation: Research Group Protein Trafficking in Synaptic Development and Function, Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry Göttingen, Germany.
authors.forename: Oleksandr
authors.initials: O
authors.lastname: Yagensky
authors.affiliation: Research Group Protein Trafficking in Synaptic Development and Function, Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry Göttingen, Germany.
authors.forename: Tahere
authors.initials: T
authors.lastname: Kalantary Dehaghi
authors.affiliation: Research Group Protein Trafficking in Synaptic Development and Function, Department of Neurobiology, Max-Planck-Institute for Biophysical ChemistryGöttingen, Germany; Interactomics and Intracellular Trafficking Laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeSingapore; Neurobiology/Ageing Programme, National University of Singapore, SingaporeSingapore.
authors.forename: John Jia En
authors.initials: JJ
authors.lastname: Chua
keywords: Dynein; autophagy; intracellular trafficking; kinesin; presynapse; signaling pathways; synaptogenesis