title: Reconsidering the role of hypothermia in management of severe traumatic brain injury.
abstract: Over the past two decades there has been considerable interest in the use of hypothermia in the management of severe traumatic brain injury. However despite promising experimental evidence, results from clinical studies have failed to demonstrate benefit. Indeed recent studies have shown a tendency to worse outcomes in those patients randomised to therapeutic hypothermia. In this narrative review the pathophysiological rationale behind hypothermia and the clinical evidence for efficacy are examined. There would still appear to be a role for hypothermia in the management of intractable intracranial hypertension. However optimising therapeutic time frames and better management of strategies for complications will be required if experimental evidence for neuroprotection is to be translated into clinical benefit.
authors.affiliation: Department of Neurosurgery, Sir Charles Gairdner Hospital and Royal Perth Hospital, Hospital Avenue, Perth, WA 6000, Australia. Electronic address: stephen.honeybul@health.wa.gov.au.
authors.forename: S
authors.initials: S
authors.lastname: Honeybul
mesh_terms: D000070642:Brain Injuries, Traumatic / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects / Q000379:methods*; D010043:Outcome and Process Assessment, Health Care
keywords: Hypothermia; Intracranial hypertension; Severe traumatic brain injury