title: VOLUMETRIC LOCALISATION OF DENSE BREAST TISSUE USING BREAST TOMOSYNTHESIS DATA.
abstract: This study attempted to use combined data from reconstructed digital breast tomosynthesis (DBT) volumes and density estimation of projection images to localise dense tissue inside the breast, using the assumption that the breast can be treated as consisting of only two types of tissue: fibroglandular (dense) and adipose (fatty). To be able to verify results, software breast phantoms generated using fractal Perlin noise were employed. Projection images were created using the PENELOPE Monte Carlo package. Dense tissue volume was estimated from the central projection image. The density image was used to determine the number of dense voxels at each pixel location, which were then placed using the DBT image as a template. The method proved capable of accurately determining the composition of 75±5 % of voxels.
authors.affiliation: Medical Radiation Physics, Department of Translational Medicine, Lund University, SUS, SE-205 02 Malmö, Sweden magnus.dustler@med.lu.se.
authors.forename: M
authors.initials: M
authors.lastname: Dustler
authors.affiliation: Medical Radiation Physics, Department of Translational Medicine, Lund University, SUS, SE-205 02 Malmö, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Petersson
authors.affiliation: Medical Radiation Physics, Department of Translational Medicine, Lund University, SUS, SE-205 02 Malmö, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Timberg
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003198:Computer Simulation; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation / Q000379:methods*; D008327:Mammography / Q000295:instrumentation / Q000379:methods*; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*