title: Adaptive Evolution: Don't Fix What's Broken.
abstract: Evolution of budding yeast after the removal of an important component of the polarization machinery, BEM1, followed reproducible evolutionary trajectories governed by epistasis. Interestingly, cells restored polarization not by finding a substitute for Bem1 but by rendering its function dispensable.
authors.affiliation: Institute of Medical Biology (IMB), Agency for Science, Technology and Research (A(∗)STAR), Singapore 138648, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
authors.forename: Gaowen
authors.initials: G
authors.lastname: Liu
authors.affiliation: Institute of Medical Biology (IMB), Agency for Science, Technology and Research (A(∗)STAR), Singapore 138648, Singapore. Electronic address: giulia.rancati@imb.a-star.edu.sg.
authors.forename: Giulia
authors.initials: G
authors.lastname: Rancati
mesh_terms: D000220:Adaptation, Biological; D048868:Adaptor Proteins, Signal Transducing / Q000172:deficiency*; D012441:Saccharomyces cerevisiae / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing