title: What Have We Learned From the Typhoid Fever Surveillance in Africa Program?
abstract: The Typhoid Fever Surveillance in Africa Program (TSAP) was established in 2009 to fill the data void concerning invasive Salmonella disease in sub-Saharan Africa, and to specifically estimate the burden of bloodstream infections caused by the key pathogen, Salmonella enterica serovar Typhi. TSAP has achieved this ambitious target, finding high incidences of typhoid fever in both rural and urban populations in several countries in sub-Saharan Africa. The results of TSAP will undoubtedly dictate the direction of future typhoid fever research in Africa, and at last provides a key piece of the disease burden jigsaw puzzle. With the dawn of new Vi conjugate vaccines against Salmonella Typhi, the next priority for the typhoid community must be providing the required data on these vaccines so they can be licensed and provided to those in high-risk groups and locations across sub-Saharan Africa.
authors.affiliation: Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam Centre for Tropical Medicine, Oxford University London School of Hygiene and Tropical Medicine, United Kingdom.
authors.forename: Stephen
authors.initials: S
authors.lastname: Baker
authors.affiliation: Initiative for Vaccine Research, World Health Organization, Geneva, Switzerland;
authors.forename: Joachim
authors.initials: J
authors.lastname: Hombach
authors.affiliation: Department of Epidemiology, International Vaccine Institute, Seoul, Republic of Korea.
authors.forename: Florian
authors.initials: F
authors.lastname: Marks
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D006801:Humans; D062486:Public Health Surveillance; D012485:Salmonella typhi; D014435:Typhoid Fever / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control
keywords: Salmonella Typhi; epidemiology; sub-Saharan Africa