title: Polygonum aviculare L. and its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing.
abstract: Polygonum aviculare L. is a member of the Polygonaceae family of plants, which has been known for its antioxidant and anti-obesity effects. However, the wound healing function of P. aviculare extract has not been assessed. In this study, we identified a novel property of P. aviculare extract as a Wnt/β-catenin pathway activator based on a screen of 350 plant extracts using HEK293-TOP cells retaining the Wnt/β-catenin signaling reporter gene. P. aviculare extract accelerated the migration of HaCaT keratinocytes without showing significant cytotoxicity. Moreover, P. aviculare extract efficiently re-epithelized wounds generated on mice. Additionally, ingredients of P. aviculare extract, such as quercitrin hydrate, caffeic acid, and rutin, also accelerated the motility of HaCaT keratinocytes with the activation of Wnt/β-catenin signaling. Therefore, based on our findings, P. aviculare extract and its active ingredients could be potential therapeutic agents for wound healing. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.|Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
authors.forename: Seol Hwa
authors.initials: SH
authors.lastname: Seo
authors.affiliation: Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.|Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
authors.forename: Soung-Hoon
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.|Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
authors.forename: Pu-Hyeon
authors.initials: PH
authors.lastname: Cha
authors.affiliation: Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.|Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
authors.forename: Mi-Yeon
authors.initials: MY
authors.lastname: Kim
authors.affiliation: Department of Molecular Biology, College of Natural Science, Pusan National University, Busan, 609-735, Korea.
authors.forename: Do Sik
authors.initials: do S
authors.lastname: Min
authors.affiliation: Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.|Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
authors.forename: Kang-Yell
authors.initials: KY
authors.lastname: Choi
mesh_terms: D000818:Animals; D002109:Caffeic Acids / Q000737:chemistry*; D006801:Humans; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D028502:Polygonum / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry; D014162:Transfection; D060449:Wnt Signaling Pathway; D014945:Wound Healing / Q000187:drug effects*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D002109:Caffeic Acids; D010936:Plant Extracts; D051176:beta Catenin; C012526:quercitrin; D011794:Quercetin; C040048:caffeic acid
keywords: Polygonum aviculare L; Wnt/β-catenin pathway; caffeic acid; cutaneous wound healing; quercitrin hydrate; rutin