title: Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology.
abstract: The purpose of this study was to develop nanosuspension based on combinative technology to enhance the intestinal absorption of Olmesartan medoxomil (OLM), a potent antihypertensive agent with limited oral bioavailability. Two combinative approaches were employed and then characterized. In vitro intestinal absorption of OLM nanosuspension and plain OLM was studied using non-everted rat intestinal sac model. Optimal OLM nanosuspension was prepared by a combination of ball milling and probe sonication using stabilizer, Poloxamer 407. The formula exhibited particle size of 469.9 nm and zeta potential of -19.1 mV, which was subjected to ex vivo studies. The flux and apparent permeability coefficient in intestine from OLM nanosuspension was higher than the plain drug, thereby suggesting better drug delivery.
authors.affiliation: Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India.
authors.forename: Zenab
authors.initials: Z
authors.lastname: Attari
authors.affiliation: Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India.
authors.forename: Amita
authors.initials: A
authors.lastname: Bhandari
authors.affiliation: Department of Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India.
authors.forename: P C
authors.initials: PC
authors.lastname: Jagadish
authors.affiliation: Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India.
authors.forename: Shaila
authors.initials: S
authors.lastname: Lewis
keywords: Combination methods; HPH, high pressure homogenization; Intestinal absorption; Nanosuspension; OLM, olmesartan medoxomil; P407, Poloxamer 407; PDI, polydispersity index; Particle size