title: Wide-field optical coherence tomography based microangiography for retinal imaging.
abstract: Optical coherence tomography angiography (OCTA) allows for the evaluation of functional retinal vascular networks without a need for contrast dyes. For sophisticated monitoring and diagnosis of retinal diseases, OCTA capable of providing wide-field and high definition images of retinal vasculature in a single image is desirable. We report OCTA with motion tracking through an auxiliary real-time line scan ophthalmoscope that is clinically feasible to image functional retinal vasculature in patients, with a coverage of more than 60 degrees of retina while still maintaining high definition and resolution. We demonstrate six illustrative cases with unprecedented details of vascular involvement in retinal diseases. In each case, OCTA yields images of the normal and diseased microvasculature at all levels of the retina, with higher resolution than observed with fluorescein angiography. Wide-field OCTA technology will be an important next step in augmenting the utility of OCT technology in clinical practice.
authors.affiliation: University of Washington, Department of Bioengineering, 3720 15th Ave NE, Seattle, WA 98195, USA.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: University of Washington, Department of Ophthalmology, 325 Ninth Avenue, Seattle, WA 98104, USA.
authors.forename: Cecilia S
authors.initials: CS
authors.lastname: Lee
authors.affiliation: University of Washington, Department of Ophthalmology, 325 Ninth Avenue, Seattle, WA 98104, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Chao
authors.affiliation: University of Washington, Department of Bioengineering, 3720 15th Ave NE, Seattle, WA 98195, USA.
authors.forename: Chieh-Li
authors.initials: CL
authors.lastname: Chen
authors.affiliation: Carl Zeiss Meditec, Inc., Dublin, CA 94568, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Carl Zeiss Meditec, Inc., Dublin, CA 94568, USA.
authors.forename: Utkarsh
authors.initials: U
authors.lastname: Sharma
authors.affiliation: University of Washington, Department of Bioengineering, 3720 15th Ave NE, Seattle, WA 98195, USA.
authors.forename: Anqi
authors.initials: A
authors.lastname: Zhang
authors.affiliation: University of Washington, Department of Bioengineering, 3720 15th Ave NE, Seattle, WA 98195, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.affiliation: University of Washington, Department of Ophthalmology, 325 Ninth Avenue, Seattle, WA 98104, USA.
authors.forename: Kasra
authors.initials: K
authors.lastname: Rezaei
authors.affiliation: University of Washington, Department of Ophthalmology, 325 Ninth Avenue, Seattle, WA 98104, USA.
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Pepple
authors.affiliation: University of Washington, Department of Ophthalmology, 325 Ninth Avenue, Seattle, WA 98104, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Munsen
authors.affiliation: University of Washington, Department of Ophthalmology, 325 Ninth Avenue, Seattle, WA 98104, USA.
authors.forename: James
authors.initials: J
authors.lastname: Kinyoun
authors.affiliation: University of Washington, Department of Ophthalmology, 325 Ninth Avenue, Seattle, WA 98104, USA.
authors.forename: Murray
authors.initials: M
authors.lastname: Johnstone
authors.affiliation: University of Washington, Department of Ophthalmology, 325 Ninth Avenue, Seattle, WA 98104, USA.
authors.forename: Russell N
authors.initials: RN
authors.lastname: Van Gelder
authors.affiliation: University of Washington, Department of Bioengineering, 3720 15th Ave NE, Seattle, WA 98195, USA.|University of Washington, Department of Ophthalmology, 325 Ninth Avenue, Seattle, WA 98104, USA.
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
mesh_terms: D000328:Adult; D003930:Diabetic Retinopathy / Q000175:diagnosis; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D055806:Microvessels; D008875:Middle Aged; D012160:Retina / Q000473:pathology; D012164:Retinal Diseases / Q000175:diagnosis*; D012171:Retinal Vessels; D012174:Retinitis Pigmentosa / Q000175:diagnosis; D041623:Tomography, Optical Coherence