title: Validation of a Spanish version of the Leicester Cough Questionnaire in non-cystic fibrosis bronchiectasis.
abstract: The Leicester Cough Questionnaire (LCQ) has been validated in non-cystic fibrosis bronchiectasis (NCFBC). The present study aimed to create and validate a Spanish version of the LCQ (LCQ-Sp) in NCFBC. The LCQ-Sp was developed following a standardized protocol. For reliability, we assessed internal consistency and the change in score over a 15-day period in stable state. For responsiveness, we assessed the change in scores between visit 1 and the first exacerbation. For validity, we evaluated convergent validity through correlation with the Saint George's Respiratory Questionnaire (SGRQ) and discriminant validity. Two hundred fifty-nine patients (118 mild bronchiectasis, 90 moderate bronchiectasis and 47 severe bronchiectasis) were included. Internal consistency was high for the total scoring and good for the different domains (Cronbach's α: 0.86-0.91). The test-retest reliability shows an intraclass correlation coefficient of 0.87 for the total score. The mean LCQ-Sp score at visit 1 decreased at the beginning of an exacerbation (15.13 ± 4.06 vs. 12.24 ± 4.64; p < 0.001). The correlation between LCQ-Sp and SGRQ scores was -0.66 (p < 0.01). The differences in the LCQ-Sp total score between the different groups of severity were significant (p < 0.001). The LCQ-Sp discriminates disease severity, is responsive to change when faced with exacerbations and is reliable for use in bronchiectasis.
authors.affiliation: Department of Medicine, Universitat Autònoma Barcelona, Barcelona, Spain Bronchiectasis Group, Girona Biomedical Research Institute, IDIBGI, Girona, Spain.
authors.forename: Gerard
authors.initials: G
authors.lastname: Muñoz
authors.affiliation: Girona Biomedical Research Institute IDIBGI, Girona, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Buxó
authors.affiliation: CIBER of Respiratory Diseases (Ciberes CB06/06/0030), Carlos III Health Institute, Spain Department of Pneumology, Vall d'Hebron University Hospital, Universitat Autònoma Barcelona, Barcelona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: de Gracia
authors.affiliation: Department of Pneumology, Malaga Regional University Hospital, Biomedical Research Institute of Malaga (IBIMA), University of Malaga, Málaga, Spain.
authors.forename: Casilda
authors.initials: C
authors.lastname: Olveira
authors.affiliation: CIBER of Respiratory Diseases (Ciberes CB06/06/0030), Carlos III Health Institute, Spain Department of Pneumology, La Fe University and Polytechnic Hospital, Valencia, Spain.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Martinez-Garcia
authors.affiliation: Department of Pneumology, Instituto de Investigación del Hospital de la Princesa, Madrid, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Giron
authors.affiliation: Fundació Clínic, IDIBAPS, Ciberes, Barcelona, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Polverino
authors.affiliation: CIBER of Respiratory Diseases (Ciberes CB06/06/0030), Carlos III Health Institute, Spain Department of Pneumology, Vall d'Hebron University Hospital, Universitat Autònoma Barcelona, Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Alvarez
authors.affiliation: Division of Asthma, Allergy and Lung Biology, Denmark Hill Campus, King's College London, Denmark Hill, London, UK.
authors.forename: Surinder S
authors.initials: SS
authors.lastname: Birring
authors.affiliation: Bronchiectasis Group, Girona Biomedical Research Institute, IDIBGI, Girona, Spain CIBER of Respiratory Diseases (Ciberes CB06/06/0030), Carlos III Health Institute, Spain mvendrell.girona.ics@gencat.cat.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Vendrell
mesh_terms: D000328:Adult; D000368:Aged; D001987:Bronchiectasis / Q000503:physiopathology*; D003371:Cough / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D000071066:Patient Reported Outcome Measures; D011446:Prospective Studies; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014177:Translations
keywords: Bronchiectasis; cough; patient-reported outcome; quality of life; questionnaire