title: Incidence and occupational variation of ovarian granulosa cell tumours in Finland, Iceland, Norway and Sweden during 1953-2012: a longitudinal cohort study.
abstract: OBJECTIVE
  To determine the incidence and occupational variation of granulosa cell tumours (GCTs) in Finland, Iceland, Norway and Sweden over a 60-year period, 1953-2012.
  
  
  METHODS
  A longitudinal cohort study.
  
  
  METHODS
  Finland, Iceland, Norway and Sweden and a total of 249 million women over a 60-year period (1953-2012). The NOCCA (Nordic Occupational Cancer Study) included 6.4 million women with 776 incident GCT cases diagnosed until the end of follow up.
  
  
  METHODS
  Incidence rates were calculated from the national cancer registries and compared using quasi-Poisson regression models. Occupation-specific standardised incidence ratios (SIRs) were calculated from the Nordic Occupational Cancer (NOCCA) database.
  
  
  METHODS
  Incidence rates and standardised incidence ratios.
  
  
  RESULTS
  The age-adjusted (World Standard) incidence rates remained quite constant: about 0.6-0.8 per 100 000 for most of the study period. The age-specific incidence was highest at 50-64 years of age. There were no occupations with significantly increased risk of GCT. Major changes in the use of oral contraceptives, postmenopausal hormonal therapy, fertility rate and lifestyle in general during the study period and among different occupational categories do not appear to have a marked effect on the incidence of GCT.
  
  
  CONCLUSIONS
  Our findings support the concept of GCT as a primarily sporadic, not exposure-related, cancer.
  
  
  CONCLUSIONS
  The Nordic incidence rates of GCTs show stability over time and among different occupational categories.
authors.affiliation: Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.|Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Bryk
authors.affiliation: Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.|School of Health Sciences, University of Tampere, Tampere, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Pukkala
authors.affiliation: Department of Research, Cancer Registry of Norway, Oslo, Norway.
authors.forename: J-I
authors.initials: JI
authors.lastname: Martinsen
authors.affiliation: Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Unkila-Kallio
authors.affiliation: Icelandic Cancer Registry, Reykjavik, Iceland.|Faculty of Medicine, Laeknagardur, University of Iceland, Reykjavik, Iceland.
authors.forename: L
authors.initials: L
authors.lastname: Tryggvadottir
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Sparén
authors.affiliation: Department of Research, Cancer Registry of Norway, Oslo, Norway.
authors.forename: K
authors.initials: K
authors.lastname: Kjaerheim
authors.affiliation: Department of Research, Cancer Registry of Norway, Oslo, Norway.|Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Weiderpass
authors.affiliation: Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Riska
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006106:Granulosa Cell Tumor / Q000453:epidemiology*; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D015994:Incidence; D008137:Longitudinal Studies; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D009790:Occupations; D010051:Ovarian Neoplasms / Q000453:epidemiology*; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology
keywords: Epidemiology; Nordic; granulosa cell tumour; incidence; occupational