title: Glycan Engineering for Cell and Developmental Biology.
abstract: Cell-surface glycans are a diverse class of macromolecules that participate in many key biological processes, including cell-cell communication, development, and disease progression. Thus, the ability to modulate the structures of glycans on cell surfaces provides a powerful means not only to understand fundamental processes but also to direct activity and elicit desired cellular responses. Here, we describe methods to sculpt glycans on cell surfaces and highlight recent successes in which artificially engineered glycans have been employed to control biological outcomes such as the immune response and stem cell fate.
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Griffin
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: lhw@caltech.edu.
authors.forename: Linda C
authors.initials: LC
authors.lastname: Hsieh-Wilson
mesh_terms: D000818:Animals; D053898:Biosynthetic Pathways; D003584:Cytological Techniques / Q000379:methods*; D015509:Developmental Biology / Q000379:methods*; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D007109:Immunity; D009844:Oligosaccharides / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D009844:Oligosaccharides; D011134:Polysaccharides