title: Fast, Highly-Sensitive, and Wide-Dynamic-Range Interdigitated Capacitor Glucose Biosensor Using Solvatochromic Dye-Containing Sensing Membrane.
abstract: In this paper, we proposed an interdigitated capacitor (IDC)-based glucose biosensor to measure different concentrations of glucose from 1 μM to 1 M. We studied four different types of solvatochromic dyes: Auramine O, Nile red, Rhodamine B, and Reichardt's dye (R-dye). These dyes were individually incorporated into a polymer [polyvinyl chloride (PVC)] and N,N-Dimethylacetamide (DMAC) solution to make the respective dielectric/sensing materials. To the best of our knowledge, we report for the first time an IDC glucose biosensing system utilizing a solvatochromic-dye-containing sensing membrane. These four dielectric or sensing materials were individually placed into the interdigitated electrode (IDE) by spin coating to make four IDC glucose biosensing elements. The proposed IDC glucose biosensor has a high sensing ability over a wide dynamic range and its sensitivity was about 23.32 mV/decade. It also has fast response and recovery times of approximately 7 s and 5 s, respectively, excellent reproducibility with a standard deviation of approximately 0.023, highly stable sensing performance, and real-time monitoring capabilities. The proposed IDC glucose biosensor was compared with an IDC, potentiometric, FET, and fiber-optic glucose sensor with respect to response time, dynamic range width, sensitivity, and linearity. We observed that the designed IDC glucose biosensor offered excellent performance.
authors.affiliation: School of Electronics Engineering, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea. rajibur@ee.knu.ac.kr.
authors.forename: Md Rajibur Rahaman
authors.initials: MR
authors.lastname: Khan
authors.affiliation: School of Electronics Engineering, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea. alireza.khalilian991@gmail.com.
authors.forename: Alireza
authors.initials: A
authors.lastname: Khalilian
authors.affiliation: School of Electronics Engineering, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea. swkang@knu.ac.kr.
authors.forename: Shin-Won
authors.initials: SW
authors.lastname: Kang
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004396:Coloring Agents / Q000737:chemistry; D004566:Electrodes; D005947:Glucose / Q000032:analysis*
chemical_list: D004396:Coloring Agents; D005947:Glucose
keywords: dielectric constant; glucose biosensor; interdigitated capacitor; sensing element; solvatochromic dye