title: Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast.
abstract: OBJECTIVE
  In order to elucidate the interrelationship of adipokines in glucose hemiostasis, we determined the concentration of visfatin and adipsin in blood samples in patients with type 2 diabetes and age-matched controls after an overnight fast.
  
  
  METHODS
  We enrolled 37 patients with known type 2 diabetes -21 males and 16 females, aged 62.95 ± 15.72 years and 43 controls- 28 males and 15 females, aged 60.79 ± 12.67 years. Blood samples were collected after an overnight fast and routine biochemical parameters such as glucose, cholesterol, HDL, LDL, triglycerides along with Hb1Ac, insulin and c-peptide, in addition to circulating visfatin and adipsin were determined in all samples. Data were considered significant at a level of p < 0.05.
  
  
  RESULTS
  In patients with type 2 diabetes, circulating adipsin levels were decreased and inversely related with glucose levels while circulating visfatin was increased significantly in the fasting state.
  
  
  CONCLUSIONS
  These results implicate the adipokines adipsin and visfatin as possible participants in the pathogenesis of type 2 diabetes.
authors.affiliation: Iaso General Hospital, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Legakis
authors.affiliation: Euromedica High Technology S.A, Athens, Greece.
authors.forename: Timos
authors.initials: T
authors.lastname: Mantzouridis
authors.affiliation: Aretaieion University Hospital, Athens Medical School, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Bouboulis
authors.affiliation: First Department of Pediatrics, School of Medicine, University of Athens, Athens, Greece.
authors.forename: George P
authors.initials: GP
authors.lastname: Chrousos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D011416:Complement Factor D / Q000032:analysis / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005215:Fasting / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*
chemical_list: D054409:Nicotinamide Phosphoribosyltransferase; D011416:Complement Factor D