title: Sub-millimetre DOI detector based on  monolithic LYSO and digital SiPM for a  dedicated small-animal PET system.
abstract: The mouse model is widely used in a vast range of biomedical and preclinical studies. Thanks to the ability to detect and quantify biological processes at the molecular level in vivo, PET has become a well-established tool in these investigations. However, the need to visualize and quantify radiopharmaceuticals in anatomic structures of millimetre or less requires good spatial resolution and sensitivity from small-animal PET imaging systems.In previous work we have presented a proof-of-concept of a dedicated high-resolution small-animal PET scanner based on thin monolithic scintillator crystals and Digital Photon Counter photosensor. The combination of thin monolithic crystals and MLE positioning algorithm resulted in an excellent spatial resolution of 0.7 mm uniform in the entire field of view (FOV). However, the limitation of the scanner was its low sensitivity due to small thickness of the lutetium-yttrium oxyorthosilicate (LYSO) crystals (2 mm).Here we present an improved detector design for a small-animal PET system that simultaneously achieves higher sensitivity and sustains a sub-millimetre spatial resolution. The proposed detector consists of a 5 mm thick monolithic LYSO crystal optically coupled to a Digital Photon Counter. Mean nearest neighbour (MNN) positioning combined with depth of interaction (DOI) decoding was employed to achieve sub-millimetre spatial resolution. To evaluate detector performance the intrinsic spatial resolution, energy resolution and coincidence resolving time (CRT) were measured. The average intrinsic spatial resolution of the detector was 0.60 mm full-width-at-half-maximum (FWHM). A DOI resolution of 1.66 mm was achieved. The energy resolution was 23% FWHM at 511 keV and CRT of 529 ps were measured. The improved detector design overcomes the sensitivity limitation of the previous design by increasing the nominal sensitivity of the detector block and retains an excellent intrinsic spatial resolution.
authors.forename: Radosław
authors.initials: R
authors.lastname: Marcinkowski
authors.forename: Pieter
authors.initials: P
authors.lastname: Mollet
authors.forename: Roel
authors.initials: R
authors.lastname: Van Holen
authors.forename: Stefaan
authors.initials: S
authors.lastname: Vandenberghe
mesh_terms: D000818:Animals; D008187:Lutetium; D051379:Mice; D017785:Photons; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods; D011829:Radiation Dosage; D012680:Sensitivity and Specificity; D017640:Silicates; D015021:Yttrium Radioisotopes
chemical_list: D017640:Silicates; D015021:Yttrium Radioisotopes; C477682:lutetium orthosilicate; D008187:Lutetium