title: A Cascade Phosphinoylation/Cyclization/Desulfonylation Process for the Synthesis of 3-Phosphinoylindoles.
abstract: 3-Phosphinoylindole derivatives play important roles as pharmaceutical drugs and ligands. A new method for the synthesis of 3-phosphinoylindole derivatives has been achieved through silver-mediated cycloaddition between N-Ts-2-alkynylaniline derivatives and H-phosphine oxides. This transformation offers a straightforward route to the formation of the C-P bond, indole ring, and desulfonylation in one step.
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen, Fujian 361005, China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen, Fujian 361005, China.
authors.forename: Guozhang
authors.initials: G
authors.lastname: Lu
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen, Fujian 361005, China.
authors.forename: Pengbo
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen, Fujian 361005, China.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen, Fujian 361005, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Tang
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen, Fujian 361005, China.|Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D012834:Silver / Q000737:chemistry
chemical_list: D007211:Indoles; D009943:Organophosphorus Compounds; D010087:Oxides; D012834:Silver