title: Circulating S100A12 Levels Are Associated with Progression of Abdominal Aortic Calcification in Hemodialysis Patients.
abstract: Vascular calcification is an important factor associated with mortality in dialysis patients. Recently, soluble receptor for advanced glycation end product (sRAGE) and extracellular RAGE binding protein S100A12 (EN-RAGE) have been reported to be involved in the process of vascular calcification. Therefore, we investigated whether sRAGE and S100A12 are useful indicators of progression of abdominal aortic calcification in hemodialysis (HD) patients. We analyzed annual changes in vascular calcification score (VCS) for up to 4 years, compared to clinical and biological parameters in 149 HD patients. VCS was assessed annually using plain X-ray images of the lateral lumbar spine. The progression group was defined as patients with an increase in VCS more than 1 point each year on average during the observation period. Time-averaged concentrations were also evaluated to examine the association between biological parameters and changes in VCS. The patients had a mean age of 58.59 ± 12.93 years; 53.7% were male, and 45% were diabetic. The VCS increased in 55 patients; the mean increase was 1.60 ± 2.91 points. In a stepwise multivariate logistic analysis, we found that higher levels of S100A12 were significantly associated with progression of VCS (odds ratio [OR], 2.622; 95% confidence interval [CI], 1.371-5.016; P = 0.004). The relationship between sRAGE and VCS was not statistically significant (OR, 0.644; 95% CI, 0.302-1.374; P = 0.255). Our findings suggest that serum levels of S100A12 are associated with progression of abdominal aortic calcification in HD patients, independent of sRAGE level.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Gachon University of Gil Medical Center, Incheon, Korea.
authors.forename: Byoung Ho
authors.initials: BH
authors.lastname: Choi
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Gachon University of Gil Medical Center, Incheon, Korea.|Gachon University School of Medicine, Incheon, Korea.
authors.forename: Han
authors.initials: H
authors.lastname: Ro
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Gachon University of Gil Medical Center, Incheon, Korea.
authors.forename: Eul Sik
authors.initials: ES
authors.lastname: Jung
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Gachon University of Gil Medical Center, Incheon, Korea.
authors.forename: Ae Jin
authors.initials: AJ
authors.lastname: Kim
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Gachon University of Gil Medical Center, Incheon, Korea.|Gachon University School of Medicine, Incheon, Korea.
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Chang
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Gachon University of Gil Medical Center, Incheon, Korea.|Gachon University School of Medicine, Incheon, Korea.
authors.forename: Hyun Hee
authors.initials: HH
authors.lastname: Lee
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Gachon University of Gil Medical Center, Incheon, Korea.|Gachon University School of Medicine, Incheon, Korea.
authors.forename: Wookyung
authors.initials: W
authors.lastname: Chung
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Gachon University of Gil Medical Center, Incheon, Korea.|Gachon University School of Medicine, Incheon, Korea.
authors.forename: Ji Yong
authors.initials: JY
authors.lastname: Jung
mesh_terms: D001012:Aorta, Abdominal / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood*; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D000067616:S100A12 Protein / Q000097:blood*; D061205:Vascular Calcification / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products; D000067616:S100A12 Protein; C090441:S100A12 protein, human; C000593871:AGER protein, human