title: Genomic approaches for understanding dengue: insights from the virus, vector, and host.
abstract: The incidence and geographic range of dengue have increased dramatically in recent decades. Climate change, rapid urbanization and increased global travel have facilitated the spread of both efficient mosquito vectors and the four dengue virus serotypes between population centers. At the same time, significant advances in genomics approaches have provided insights into host-pathogen interactions, immunogenetics, and viral evolution in both humans and mosquitoes. Here, we review these advances and the innovative treatment and control strategies that they are inspiring.
authors.affiliation: Infectious Diseases, Genome Institute of Singapore, Singapore, 138672, Singapore.
authors.forename: Shuzhen
authors.initials: S
authors.lastname: Sim
authors.affiliation: Infectious Diseases, Genome Institute of Singapore, Singapore, 138672, Singapore. hibberdml@gis.a-star.edu.sg.|Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. hibberdml@gis.a-star.edu.sg.
authors.forename: Martin L
authors.initials: ML
authors.lastname: Hibberd
mesh_terms: D000818:Animals; D057231:Climate Change; D009033:Culicidae / Q000472:pathogenicity / Q000821:virology; D003715:Dengue / Q000235:genetics* / Q000473:pathology / Q000821:virology; D003716:Dengue Virus / Q000235:genetics* / Q000472:pathogenicity; D023281:Genomics; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D007303:Insect Vectors / Q000472:pathogenicity / Q000821:virology