title: Association between periodontitis and salivary 8-hydroxydeoxyguanosine among Korean rural adults.
abstract: This study aimed to evaluate the association between salivary 8-hydroxydeoxyguanosine (8-OHdG) and periodontitis among community-dwelling Korean adults.
  
  
  
  A total of 211 adults (80 men and 131 women) were cross-sectionally surveyed from the Sunchang Longevity Cohort. Periodontitis was defined as having at least 30% of teeth with proximal attachment loss ≥5 mm. The salivary 8-OHdG level was categorized into tertiles: low (<0.916 ng/ml), medium (0.916 to <2.675 ng/ml) and high (≥2.675 ng/ml). Sociodemographic, habitual and systemic health-related factors were controlled for. Logistic regression analysis was performed for the outcome of severe periodontitis. Analysis of covariance in general linear model was performed for the outcome of 8-OHdG.
  
  
  
  The high 8-OHdG level showed a significant association with periodontitis. The odds ratio (95% confidence interval) was 2.40 (1.05-5.51), and it was highlighted by adding the interaction term with drinking and smoking. The adjusted mean log-transformed value of 8-OHdG was significantly higher in the severe periodontitis group (1.40 ng/ml) than in the control group (1.02 ng/ml) (ancova, P = 0.028).
  
  
  
  8-OHdG was associated with periodontitis. Thus, salivary 8-OHdG could be a useful marker for periodontitis.
authors.affiliation: Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Myung-Seop
authors.initials: MS
authors.lastname: Shin
authors.affiliation: Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Shin
authors.affiliation: Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Yoo-Been
authors.initials: YB
authors.lastname: Ahn
authors.affiliation: Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.|Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Hyun-Duck
authors.initials: HD
authors.lastname: Kim
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000032:analysis; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000175:diagnosis / Q000378:metabolism*; D056910:Republic of Korea / Q000453:epidemiology; D012424:Rural Population / Q000706:statistics & numerical data; D027544:Salvia / Q000737:chemistry*
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine
keywords: 8-OHdG; epidemiology; oxidative stress; periodontitis; saliva