title: Declining Effectiveness of Herpes Zoster Vaccine in Adults Aged ≥60 Years.
abstract: Understanding long-term effectiveness of herpes zoster (HZ) vaccine is critical for determining vaccine policy. 176 078 members of Kaiser Permanente ≥60 years vaccinated with HZ vaccine and three matched unvaccinated members were included. Hazard ratios and 95% confidence intervals (CIs) associated with vaccination at each year following vaccination were estimated by Cox regression model. The effectiveness of HZ vaccine decreased from 68.7% (95% CI, 66.3%-70.9%) in the first year to 4.2% (95% CI, -24.0% to 25.9%) in the eighth year. This rapid decline in effectiveness of HZ vaccine suggests that a revaccination strategy may be needed, if feasible.
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
authors.forename: Hung Fu
authors.initials: HF
authors.lastname: Tseng
authors.affiliation: Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Rafael
authors.initials: R
authors.lastname: Harpaz
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Craig M
authors.initials: CM
authors.lastname: Hales
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
authors.forename: Lina S
authors.initials: LS
authors.lastname: Sy
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
authors.forename: Sara Y
authors.initials: SY
authors.lastname: Tartof
authors.affiliation: Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Bialek
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
authors.forename: Rulin C
authors.initials: RC
authors.lastname: Hechter
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Jacobsen
mesh_terms: D000368:Aged; D006562:Herpes Zoster / Q000276:immunology*; D053061:Herpes Zoster Vaccine / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D008875:Middle Aged; D011050:Policy Making; D016016:Proportional Hazards Models; D016896:Treatment Outcome; D014611:Vaccination
chemical_list: D053061:Herpes Zoster Vaccine
keywords: adult vaccination; herpes zoster; shingles; varicella zoster virus