title: [Issues and current limits for immunohistochemical assessment of PD-L1 status in bronchial biopsies].
abstract: Immunotherapy targeting the PD-L1/PD-1 axis has shown recently some promising results in metastatic lung cancer patients. This treatment seems to be more effective when a high expression of PD-L1 is detected by immunohistochemistry in bronchial biopsies. In this regard, this targeted therapy will be proposed soon in metastatic lung cancer patients. This immunotherapy could be dependent to the immunohistochemical (IHC) assessment of PD-L1 expression, thus considered as a companion diagnostic test. This near perspective poses challenges with regard to the positivity threshold value for PD-L1 expression before therapy administration, the positive cellular compartment (tumour cells and/or immune cells), the percentage of positive cells and the clone which is used. A couple of patients have a good response to treatment targeting the PD-1/PD-L1 axis despite the absence or a weak PD-L1 expression. However the assessment of PD-L1 expression by immunohistochemistry will be the only mandatory approach before therapeutic strategies targeting the PD1/PD-L1 axis for lung cancer patients. In this review, the main challenges of using PD-L1 immunohistochemistry as a potential companion diagnostic tool for metastatic lung cancer patient immunotherapy will be discussed.
authors.affiliation: Université de Nice Sophia Antipolis, CHU de Nice, hôpital Pasteur, laboratoire de pathologie clinique et expérimentale et biobanque (BB-0033-00025), 30, avenue de la voie Romaine, 06002 Nice cedex 01, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Hofman
authors.affiliation: Université de Nice Sophia Antipolis, CHU de Nice, hôpital Pasteur, laboratoire de pathologie clinique et expérimentale et biobanque (BB-0033-00025), 30, avenue de la voie Romaine, 06002 Nice cedex 01, France.
authors.forename: Marius
authors.initials: M
authors.lastname: Ilie
authors.affiliation: Université de Nice Sophia Antipolis, CHU de Nice, hôpital Pasteur, laboratoire de pathologie clinique et expérimentale et biobanque (BB-0033-00025), 30, avenue de la voie Romaine, 06002 Nice cedex 01, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Long
authors.affiliation: Université de Nice Sophia Antipolis, CHU de Nice, hôpital Pasteur, laboratoire de pathologie clinique et expérimentale et biobanque (BB-0033-00025), 30, avenue de la voie Romaine, 06002 Nice cedex 01, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Butori
authors.affiliation: Université de Nice Sophia Antipolis, CHU de Nice, hôpital Pasteur, laboratoire de pathologie clinique et expérimentale et biobanque (BB-0033-00025), 30, avenue de la voie Romaine, 06002 Nice cedex 01, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Lassalle
authors.affiliation: Université de Nice Sophia Antipolis, CHU de Nice, hôpital Pasteur, laboratoire de pathologie clinique et expérimentale et biobanque (BB-0033-00025), 30, avenue de la voie Romaine, 06002 Nice cedex 01, France.
authors.forename: Kevin
authors.initials: K
authors.lastname: Washetine
authors.affiliation: Université de Nice Sophia Antipolis, CHU de Nice, hôpital Pasteur, laboratoire de pathologie clinique et expérimentale et biobanque (BB-0033-00025), 30, avenue de la voie Romaine, 06002 Nice cedex 01, France.
authors.forename: Salomé
authors.initials: S
authors.lastname: Lalve
authors.affiliation: CHU de Nice, hôpital Pasteur, service de pneumologie, 30, avenue de la voie Romaine, 06002 Nice cedex 01, France.
authors.forename: Charles-Hugo
authors.initials: CH
authors.lastname: Marquette
authors.affiliation: University Paris Sud, Institut Gustave-Roussy, Inserm U981, 114, rue Edouard-Vaillant, 94800 Villejuif, France.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Soria
authors.affiliation: Université de Nice Sophia Antipolis, CHU de Nice, hôpital Pasteur, laboratoire de pathologie clinique et expérimentale et biobanque (BB-0033-00025), 30, avenue de la voie Romaine, 06002 Nice cedex 01, France. Electronic address: hofman.p@chu-nice.fr.
authors.forename: Paul
authors.initials: P
authors.lastname: Hofman
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D060890:B7-H1 Antigen / Q000032:analysis* / Q000037:antagonists & inhibitors; D001706:Biopsy; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007167:Immunotherapy; D008168:Lung / Q000737:chemistry* / Q000473:pathology; D008175:Lung Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000628:therapy; D009363:Neoplasm Proteins / Q000032:analysis / Q000037:antagonists & inhibitors
chemical_list: D000951:Antigens, Neoplasm; D060890:B7-H1 Antigen; D009363:Neoplasm Proteins
keywords: Cancer du poumon; Immunohistochemistry; Immunohistochimie; Immunotherapy; Immunothérapie; Limites; Limits; Lung cancer; PD-1; PD-L1