title: Resting state connectivity and cognitive performance in adults with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
abstract: Cognitive impairment is an inevitable feature of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), affecting executive function, attention and processing speed from an early stage. Impairment is associated with structural markers such as lacunes, but associations with functional connectivity have not yet been reported. Twenty-two adults with genetically-confirmed CADASIL (11 male; aged 49.8 ± 11.2 years) underwent functional magnetic resonance imaging at rest. Intrinsic attentional/executive networks were identified using group independent components analysis. A linear regression model tested voxel-wise associations between cognitive measures and component spatial maps, and Pearson correlations were performed with mean intra-component connectivity z-scores. Two frontoparietal components were associated with cognitive performance. Voxel-wise analyses showed an association between one component cluster and processing speed (left middle temporal gyrus; peak -48, -18, -14; ZE = 5.65, pFWE corr = 0.001). Mean connectivity in both components correlated with processing speed (r = 0.45, p = 0.043; r = 0.56, p = 0.008). Mean connectivity in one component correlated with faster Trailmaking B minus A time (r = -0.77, p < 0.001) and better executive performance (r = 0.56, p = 0.011). This preliminary study provides evidence for associations between cognitive performance and attentional network connectivity in CADASIL. Functional connectivity may be a useful biomarker of cognitive performance in this population.
authors.affiliation: Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK Breda.Cullen@glasgow.ac.uk.
authors.forename: Breda
authors.initials: B
authors.lastname: Cullen
authors.affiliation: Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.
authors.forename: Fiona C
authors.initials: FC
authors.lastname: Moreton
authors.affiliation: Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Stringer
authors.affiliation: Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Krishnadas
authors.affiliation: Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.
authors.forename: Dheeraj
authors.initials: D
authors.lastname: Kalladka
authors.affiliation: Clinical Physics, NHS Greater Glasgow and Clyde, Glasgow, UK.
authors.forename: Maria R
authors.initials: MR
authors.lastname: López-González
authors.affiliation: Neuroradiology, NHS Greater Glasgow and Clyde, Glasgow, UK.
authors.forename: Celestine
authors.initials: C
authors.lastname: Santosh
authors.affiliation: Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK Faculty of Applied Science and Mechatronics, University of Applied Sciences, Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Schwarzbauer
authors.affiliation: Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.
authors.forename: Keith W
authors.initials: KW
authors.lastname: Muir
mesh_terms: D000328:Adult; D046589:CADASIL / Q000150:complications / Q000503:physiopathology*; D002544:Cerebral Infarction / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology; D056344:Executive Function; D006801:Humans; D056784:Leukoencephalopathies / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
keywords: CADASIL; cognition; functional magnetic resonance imaging; resting state; small vessel disease