title: Ulcerative Colitis Remission Status After Induction With Mesalazine Predicts Maintenance Outcomes: the MOMENTUM Trial.
abstract: OBJECTIVE
  This study assessed the efficacy of maintenance treatment with multimatrix mesalazine following achievement of complete or partial remission after induction treatment with high-dose multimatrix mesalazine.
  
  
  METHODS
  In this phase 3b/4, open-label, multicentre, prospective, single-arm study, patients with mild-to-moderate ulcerative colitis were treated with multimatrix mesalazine 4.8g/day once daily for 8 weeks [induction phase]. At Week 8, those who achieved complete or partial remission, based on predefined clinical and endoscopic criteria, were eligible to receive 12 months of multimatrix mesalazine 2.4g/day once daily maintenance therapy. The primary endpoint was the proportion of patients in complete remission at Month 12.
  
  
  RESULTS
  A total of 717 patients received induction treatment; 25.9% and 39.3% of patients achieved complete and partial remission, respectively, at Week 8. A total of 461 patients entered the maintenance phase. The likelihood of remaining in/achieving complete remission at Month 12 was higher for patients who entered the maintenance phase in complete remission compared with those who began maintenance in partial remission [47.8% vs 26.0%; p < 0.001]. At Month 12, mucosal healing [endoscopy score ≤ 1] was demonstrated in 76.4% [139/182] and 63.5% [176/277] of those who were in complete and partial remission, respectively, at the end of induction.
  
  
  CONCLUSIONS
  Patients achieving complete remission before dose reduction were more likely to remain in remission at Month 12.
authors.affiliation: University of Chicago Medicine, Inflammatory Bowel Disease Center, Chicago, IL, USA.
authors.forename: David T
authors.initials: DT
authors.lastname: Rubin
authors.affiliation: CHUQ Research Center, L'Hôtel-Dieu de Québec, Québec, Canada.
authors.forename: Marc
authors.initials: M
authors.lastname: Bradette
authors.affiliation: Orlickoustecka Nemocnice a.s., Department of Internal Medicine, Ústí nad Orlicí, Czech Republic.
authors.forename: Libor
authors.initials: L
authors.lastname: Gabalec
authors.affiliation: University of Medicine and Pharmacy Târgu Mures, Gastroenterology Department, Târgu Mures, Romania.
authors.forename: Daniela
authors.initials: D
authors.lastname: Dobru
authors.affiliation: Department of Colorectal Surgery, Clínica Las Américas, Medellin, Columbia.
authors.forename: Juan
authors.initials: J
authors.lastname: Márquez
authors.affiliation: Shire, Basingstoke, UK.
authors.forename: Susi
authors.initials: S
authors.lastname: Inglis
authors.affiliation: Shire, Wayne, PA, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Magee
authors.affiliation: Shire, Wayne, PA, USA.
authors.forename: Dory
authors.initials: D
authors.lastname: Solomon
authors.affiliation: Academic Medical Centre, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands g.dhaens@amc.uva.nl.
authors.forename: Geert
authors.initials: G
authors.lastname: D'Haens
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D060828:Induction Chemotherapy; D060046:Maintenance Chemotherapy; D008297:Male; D019804:Mesalamine / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine
keywords: 5-aminosalicylic acid [5-ASA]; Inflammatory bowel disease; MOMENTUM