title: Prevalence and organ distribution of leukocyte chemotactic factor 2 amyloidosis (ALECT2) among decedents in New Mexico.
abstract: Leukocyte chemotactic factor 2 (LECT2) amyloidosis is one of the most recently described types of amyloidosis. Since its description, it has been found to be one the most common types of amyloidosis in large series of amyloid cases involving the kidney and liver in the United States, where it primarily affects patients of Hispanic ethnicity. We sought to investigate the prevalence of this disease among Hispanic adult decedents who had an autopsy performed at the New Mexico Office of the Medical Investigator and determine the organ distribution of amyloid deposition. LECT2 amyloid deposits were identified within the kidney in 3.1% of Hispanic decedents. It was consistently deposited in the liver, spleen, adrenals, and lungs but did not involve the myocardium or brain. LECT2 amyloidosis is likely not rare among Hispanics in the Southwest United States and could represent an important but under-recognized etiology of chronic kidney disease in this population.
authors.affiliation: a Nephropath , Little Rock AR , USA and.
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Larsen
authors.affiliation: a Nephropath , Little Rock AR , USA and.
authors.forename: Marjorie L
authors.initials: ML
authors.lastname: Beggs
authors.affiliation: a Nephropath , Little Rock AR , USA and.
authors.forename: Jon D
authors.initials: JD
authors.lastname: Wilson
authors.affiliation: b UNM Health Sciences Center, Office of the Medical Investigator , Albuquerque , NM , USA.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Lathrop
mesh_terms: D000311:Adrenal Glands / Q000737:chemistry / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000686:Amyloidosis / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006630:Hispanic or Latino; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D007668:Kidney / Q000737:chemistry* / Q000473:pathology; D008099:Liver / Q000737:chemistry / Q000473:pathology; D008168:Lung / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D015206:Southwestern United States / Q000453:epidemiology; D013154:Spleen / Q000737:chemistry / Q000473:pathology
chemical_list: D000682:Amyloid; D036341:Intercellular Signaling Peptides and Proteins; C103468:LECT2 protein, human
keywords: Amyloidosis; Hispanic; LECT2; autopsy; chronic kidney disease; leukocyte chemotactic factor 2; renal biopsy