title: Metal-dependent Deacetylases: Cancer and Epigenetic Regulators.
abstract: Epigenetic regulation is a key factor in cellular homeostasis. Post-translational modifications (PTMs) are a central focus of this regulation as they function as signaling markers within the cell. Lysine acetylation is a dynamic, reversible PTM that has garnered recent attention due to alterations in various types of cancer. Acetylation levels are regulated by two opposing enzyme families: lysine acetyltransferases (KATs) and histone deacetylases (HDACs). HDACs are key players in epigenetic regulation and have a role in the silencing of tumor suppressor genes. The dynamic equilibrium of acetylation makes HDACs attractive targets for drug therapy. However, substrate selectivity and biological function of HDAC isozymes is poorly understood. This review outlines the current understanding of the roles and specific epigenetic interactions of the metal-dependent HDACs in addition to their roles in cancer.
authors.affiliation: Interdepartmental Program in Chemical Biology, University of Michigan , 210 Washtenaw Avenue, Ann Arbor, Michigan 48109-2216, United States.
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: López
authors.affiliation: Interdepartmental Program in Chemical Biology, University of Michigan , 210 Washtenaw Avenue, Ann Arbor, Michigan 48109-2216, United States.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Sullivan
authors.affiliation: Interdepartmental Program in Chemical Biology, University of Michigan , 210 Washtenaw Avenue, Ann Arbor, Michigan 48109-2216, United States.|Departments of Chemistry and Biological Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109-2216, United States.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Fierke
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D008670:Metals / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*
chemical_list: D008670:Metals; D006655:Histone Deacetylases