title: The Intersection of Structural and Chemical Biology - An Essential Synergy.
abstract: The continual improvement in our ability to generate high resolution structural models of biological molecules has stimulated and supported innovative chemical biology projects that target increasingly challenging ligand interaction sites. In this review we outline some of the recent developments in chemical biology and rational ligand design and show selected examples that illustrate the synergy between these research areas.
authors.affiliation: Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Zuercher
authors.affiliation: Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Elkins
authors.affiliation: Institute for Pharmaceutical Chemistry and Buchmann Institute for Life Sciences, Johann Wolfgang Goethe University, Riedberg Campus, 60438 Frankfurt am Main, Germany; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK. Electronic address: knapp@pharmchem.uni-frankfurt.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Knapp
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray / Q000379:methods; D015195:Drug Design; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology
chemical_list: D008024:Ligands; D011506:Proteins; D054852:Small Molecule Libraries