title: Anaerobic Fermentation for Production of Carboxylic Acids as Bulk Chemicals from Renewable Biomass.
abstract: Biomass represents an abundant carbon-neutral renewable resource which can be converted to bulk chemicals to replace petrochemicals. Carboxylic acids have wide applications in the chemical, food, and pharmaceutical industries. This chapter provides an overview of recent advances and challenges in the industrial production of various types of carboxylic acids, including short-chain fatty acids (acetic, propionic, butyric), hydroxy acids (lactic, 3-hydroxypropionic), dicarboxylic acids (succinic, malic, fumaric, itaconic, adipic, muconic, glucaric), and others (acrylic, citric, gluconic, pyruvic) by anaerobic fermentation. For economic production of these carboxylic acids as bulk chemicals, the fermentation process must have a sufficiently high product titer, productivity and yield, and low impurity acid byproducts to compete with their petrochemical counterparts. System metabolic engineering offers the tools needed to develop novel strains that can meet these process requirements for converting biomass feedstock to the desirable product.
authors.affiliation: School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, 510006, P.R. China.|William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Jufang
authors.initials: J
authors.lastname: Wang
authors.affiliation: Bioprocessing Innovative Company, 4734 Bridle Path Ct., Dublin, OH, 43017, USA.
authors.forename: Meng
authors.initials: M
authors.lastname: Lin
authors.affiliation: William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Xu
authors.affiliation: William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, 43210, USA. yang.15@osu.edu.
authors.forename: Shang-Tian
authors.initials: ST
authors.lastname: Yang
mesh_terms: D000693:Anaerobiosis / Q000502:physiology; D001421:Bacteria, Anaerobic / Q000378:metabolism*; D001673:Biodegradation, Environmental; D056804:Biofuels / Q000382:microbiology*; D018533:Biomass; D019149:Bioreactors / Q000382:microbiology*; D002264:Carboxylic Acids / Q000302:isolation & purification / Q000378:metabolism; D003247:Conservation of Natural Resources / Q000379:methods*; D005285:Fermentation; D059205:Renewable Energy
chemical_list: D056804:Biofuels; D002264:Carboxylic Acids
keywords: Anaerobic fermentation; Biomass; Bulk chemical; Carboxylic acid; Metabolic engineering