title: Surgery as a Recurrent Trigger for Immune Thrombocytopenia (ITP) in a Patient Cured of M7 Acute Myelogenous Leukemia.
abstract: We report the case of a 10-year-old boy, 8 years post-M7 acute myeloid leukemia with a history of significant thrombocytopenia and bleeding, requiring treatment, after 2 surgical procedures performed under general anesthesia. In both instances, the thrombocytopenia and bleeding responded to intravenous immunoglobulin treatment. Between surgeries, the platelet counts were normal. Before a third surgical procedure, he was successfully pretreated with dexamethasone and experienced no bleeding or thrombocytopenia after the operation. This case highlights the potential utility of corticosteroid pretreatment in patients with a history of immune thrombocytopenia before surgical procedures under general anesthesia.
authors.affiliation: *Cummings School of Medicine, University of Calgary, Calgary †Division of Pediatric Immunology, Hematology, Oncology & Palliative Care, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Monfries
authors.forename: Mark
authors.initials: M
authors.lastname: Belletrutti
authors.forename: Sarah
authors.initials: S
authors.lastname: McKillop
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002648:Child; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D011183:Postoperative Complications / Q000209:etiology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology*; D012008:Recurrence
chemical_list: D000305:Adrenal Cortex Hormones