title: A short-term zinc-deficient diet decreases bone formation through down-regulated BMP2 in rat bone.
abstract: We investigated the effects of a short-term dietary zinc deficiency on bone metabolism. Zinc deficiency increased the mRNA expression of zinc uptake transporters such as Zip1, Zip13, and Zip14 in bone. However, zinc deficiency might not maintain zinc storage in bone, resulting in a decrease in bone formation through downregulation of the expression levels of osteoblastogenesis-related genes.
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Katsumata
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuzaki
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Kazuharu
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D027682:Cation Transport Proteins / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D024042:Collagen Type I / Q000097:blood / Q000235:genetics; D050659:Core Binding Factor Alpha 1 Subunit / Q000235:genetics / Q000378:metabolism; D004032:Diet; D005269:Femur / Q000378:metabolism*; D005786:Gene Expression Regulation; D008297:Male; D010006:Osteoblasts / Q000378:metabolism*; D015675:Osteocalcin / Q000097:blood / Q000235:genetics; D010012:Osteogenesis / Q000235:genetics*; D010455:Peptides / Q000097:blood / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction; D000076182:Sp7 Transcription Factor; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D015032:Zinc / Q000172:deficiency*
chemical_list: C525719:Bmp2 protein, mouse; D055396:Bone Morphogenetic Protein 2; D027682:Cation Transport Proteins; D024042:Collagen Type I; D050659:Core Binding Factor Alpha 1 Subunit; D010455:Peptides; C493716:Runx2 protein, mouse; C500556:SLC39A14 protein, mouse; C485744:Slc39a1 protein, mouse; C000611124:Slc39a13 protein, mouse; D000076182:Sp7 Transcription Factor; C479466:Sp7 protein, mouse; D014157:Transcription Factors; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D015032:Zinc
keywords: bone formation; short-term zinc deficiency; zinc transporter