title: Leukaemia 'firsts' in cancer research and treatment.
abstract: Our understanding of cancer biology has been radically transformed over recent years with a more realistic grasp of its multilayered cellular and genetic complexity. These advances are being translated into more selective and effective treatment of cancers and, although there are still considerable challenges, particularly with drug resistance and metastatic disease, many patients with otherwise lethal malignancies now enjoy protracted remissions or cure. One largely unheralded theme of this story is the extent to which new biological insights and novel clinical applications have their origins with leukaemia and related blood cell cancers, including lymphoma. In this Timeline article, I review the remarkable and ground-breaking role that studies in leukaemia have had at the forefront of this progress.
authors.affiliation: Centre for Evolution and Cancer, The Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton SM2 5NG, UK.
authors.forename: Mel
authors.initials: M
authors.lastname: Greaves
mesh_terms: D006801:Humans; D007938:Leukemia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D008223:Lymphoma / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*