title: The Significance of a Common Idiotype (1F7) on Antibodies against Human Immune Deficiency Virus Type 1 and Hepatitis C Virus.
abstract: In this review, we trace the concept and potential functional role of regulatory idiotypes in the immune response to human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus, and hepatitis C virus (HCV). A major idiotype involved in these viral infections is recognized and defined by a murine monoclonal antibody (1F7). Antibodies expressing the idiotype defined by 1F7 are dominant in HIV-1 infection and are also found on many broadly neutralizing antibodies against HIV-1. This regulatory idiotypic axis offers opportunities for exploitation in vaccine development for HIV-1, HCV, and other chronic viral infections.
authors.affiliation: Immpheron, Inc. , Lexington, KY , USA.
authors.forename: Sybille
authors.initials: S
authors.lastname: Muller
authors.affiliation: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne , Melbourne, VIC , Australia.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Parsons
authors.affiliation: Department of Microbiology and Immunology, University of Kentucky , Lexington, KY , USA.
authors.forename: Heinz
authors.initials: H
authors.lastname: Kohler
authors.affiliation: Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland , St. John's, NL , Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Grant
keywords: 1F7; HCV; HIV; SIV; idiotype