title: [Value of perineural invasion in prostatectomy specimen in the assessment on tumor progression and prognosis].
abstract: OBJECTIVE
  To assess perineural invasion in prostatectomy specimen(PNIp)on tumor progression and prognosis after radical prostatectomy.
  
  
  METHODS
  Retrospective analysis including 502 prostate cancer patients admitted in Renji Hospital, School of Medicine, Shanghai Jiaotong University from December 2002 to May 2014 was studied.Differences of serum prostate specific antigen(PSA), Gleason score of prostate biopsy, Gleason score of prostatectomy specimen, tumor stage, capsular invasion, positive surgical margin, seminal invasion, pelvic lymph node metastasis, nadir PSA were analyzed in patients with PNIp and without PNIp. Logistic regression analysis, Log-rank test and Cox regression analysis was used to analyzed the data, respectively.
  
  
  RESULTS
  There were 91 patients with PNIp(18.1%) and 411 patients without PNIp(81.9%). Differences of serum PSA, Gleason score of prostate biopsy, Gleason score of prostatectomy specimen, tumor stage, capsular invasion, seminal invasion, nadir PSA between the two groups were found(all P<0.05). In the multivariable logistic regression analysis, PNIp was independent predictor of Gleason score of prostate biopsy, Gleason score of prostatectomy specimen, tumor stage, capsular invasion(OR=1.515, 1.955, 2.069, 1.859, all P<0.05). One hundred and twenty-one patients with biochemical serum recurrence(26.7%). Serum PSA, Gleason score of prostate biopsy, Gleason score of prostatectomy specimen, tumor stage, PNIp, seminal invasion were related to biochemical serum recurrence(P<0.05). In the multivariable cox regression analysis, serum PSA, Gleason score of prostate biopsy, PNIp, seminal invasion were independent predictors of biochemical serum recurrence(HR=1.021, 1.441, 1.663, 3.257, all P<0.05).
  
  
  CONCLUSIONS
  PNIp is the important predictor of the tumor progression and prognosis of prostate cancer.
authors.affiliation: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Zhu
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Wang
authors.forename: J H
authors.initials: JH
authors.lastname: Pan
authors.forename: B J
authors.initials: BJ
authors.lastname: Dong
authors.forename: F
authors.initials: F
authors.lastname: Xu
authors.forename: J J
authors.initials: JJ
authors.lastname: Sha
authors.forename: W
authors.initials: W
authors.lastname: Xue
authors.forename: Y R
authors.initials: YR
authors.lastname: Huang
mesh_terms: D001706:Biopsy; D002681:China; D006801:Humans; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D010388:Pelvis; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies