title: Prognostic value of immunohistochemical expression profile of epidermal growth factor receptor in urothelial bladder cancer.
abstract: We studied epidermal growth factor receptor (EGFR) expression profile in urothelial bladder carcinoma (UBC) which is a complex and heterogeneous disease with a large spectrum of histological aspects and deadly potential. Using immunohistochemistry (IHC), all GI tumors and pTa cases showed a low expression profile of EGFR. However, we note that when the stage of disease is advanced, tumors over-express EGFR. Indeed, 5% and 25% of GII and GIII tumors over-expressed EGFR, respectively. Further, 0% of pTa, 9,5% of pT1, 15% of pT2, 50% of pT3, and 90% of pT4 tumors were shown to be high EGFR expression (HEE). Moreover, we found a statistically significant correlation between the EGFR over-expression and grade and stage (P < 0.05). Thus, EGFR over-expression could be a potential prognostic marker to predict poor outcome in Tunisian patients with UBC.
authors.affiliation: a Department of Pathology , Charles Nicolle University Hospital , Tunis , Tunisia.
authors.forename: Amira Toumi
authors.initials: AT
authors.lastname: Arfaoui
authors.affiliation: a Department of Pathology , Charles Nicolle University Hospital , Tunis , Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Mejri
authors.affiliation: a Department of Pathology , Charles Nicolle University Hospital , Tunis , Tunisia.
authors.forename: R
authors.initials: R
authors.lastname: Belhaj
authors.affiliation: b Department of Urology , Charles Nicolle University Hospital , Tunis , Tunisia.
authors.forename: W
authors.initials: W
authors.lastname: Karkni
authors.affiliation: b Department of Urology , Charles Nicolle University Hospital , Tunis , Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Chebil
authors.affiliation: a Department of Pathology , Charles Nicolle University Hospital , Tunis , Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Rammeh
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000096:biosynthesis / Q000276:immunology; D066246:ErbB Receptors / Q000032:analysis* / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D066246:ErbB Receptors
keywords: EGFR; immunohistochemistry; marker; over-expression; prognosis; urothelial bladder cancer