title: Toward precision medicine of breast cancer.
abstract: In this review, we report on breast cancer's molecular features and on how high throughput technologies are helping in understanding the dynamics of tumorigenesis and cancer progression with the aim of developing precision medicine methods. We first address the current state of the art in breast cancer therapies and challenges in order to progress towards its cure. Then, we show how the interaction of high-throughput technologies with in silico modeling has led to set up useful inferences for promising strategies of target-specific therapies with low secondary effect incidence for patients. Finally, we discuss the challenge of pharmacogenetics in the clinical practice of cancer therapy. All these issues are explored within the context of precision medicine.
authors.affiliation: Laboratório de Modelagem de Sistemas Biológicos, National Institute of Science and Technology for Innovation in Neglected Diseases (INCT/IDN, CNPq), Centro de Desenvolvimento Tecnológico em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. nicolas.carels@cdts.fiocruz.br.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Carels
authors.affiliation: Laboratório de Modelagem de Sistemas Biológicos, National Institute of Science and Technology for Innovation in Neglected Diseases (INCT/IDN, CNPq), Centro de Desenvolvimento Tecnológico em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. lizaspinasse@gmail.com.
authors.forename: Lizânia Borges
authors.initials: LB
authors.lastname: Spinassé
authors.affiliation: Laboratório de Modelagem de Sistemas Biológicos, National Institute of Science and Technology for Innovation in Neglected Diseases (INCT/IDN, CNPq), Centro de Desenvolvimento Tecnológico em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. tatiana@cdts.fiocruz.br.
authors.forename: Tatiana Martins
authors.initials: TM
authors.lastname: Tilli
authors.affiliation: Department of Oncology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, T6G 1Z2, Canada. jackt@ualberta.ca.|Department of Physics, University of Alberta, Edmonton, AB, T6G 2E1, Canada. jackt@ualberta.ca.
authors.forename: Jack Adam
authors.initials: JA
authors.lastname: Tuszynski
mesh_terms: D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control / Q000628:therapy*; D049109:Cell Proliferation; D019295:Computational Biology; D004247:DNA / Q000378:metabolism; D005260:Female; D053263:Gene Regulatory Networks; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D015994:Incidence; D007249:Inflammation; D053208:Kaplan-Meier Estimate; D008954:Models, Biological; D010597:Pharmacogenetics; D057285:Precision Medicine / Q000379:methods*; D025941:Protein Interaction Mapping; D020543:Proteome; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology; D059467:Transcriptome
chemical_list: D006728:Hormones; D020543:Proteome; D004247:DNA