title: Cyclodextrin-Based Metal-Organic Nanotube as Fluorescent Probe for Selective Turn-On Detection of Hydrogen Sulfide in Living Cells Based on H2S-Involved Coordination Mechanism.
abstract: Hydrogen sulfide (H2S) has been considered as the third biologically gaseous messenger (gasotransmitter) after nitric oxide (NO) and carbon monoxide (CO). Fluorescent detection of H2S in living cells is very important to human health because it has been found that the abnormal levels of H2S in human body can cause Alzheimer's disease, cancers and diabetes. Herein, we develop a cyclodextrin-based metal-organic nanotube, CD-MONT-2, possessing a {Pb14} metallamacrocycle for efficient detection of H2S. CD-MONT-2' (the guest-free form of CD-MONT-2) exhibits turn-on detection of H2S with high selectivity and moderate sensitivity when the material was dissolved in DMSO solution. Significantly, CD-MONT-2' can act as a fluorescent turn-on probe for highly selective detection of H2S in living cells. The sensing mechanism in the present work is based on the coordination of H2S as the auxochromic group to the central Pb(II) ion to enhance the fluorescence intensity, which is studied for the first time.
authors.affiliation: State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao Shandong 266580, China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Xin
authors.affiliation: Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266580, China.
authors.forename: Jingxin
authors.initials: J
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao Shandong 266580, China.
authors.forename: Chuanfang
authors.initials: C
authors.lastname: Gong
authors.affiliation: Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266580, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao Shandong 266580, China.
authors.forename: Rongming
authors.initials: R
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao Shandong 266580, China.
authors.forename: Shijie
authors.initials: S
authors.lastname: Ji
authors.affiliation: State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao Shandong 266580, China.
authors.forename: Hanxiao
authors.initials: H
authors.lastname: Dong
authors.affiliation: Chemistry &Chemical and Environmental Engineering College, Weifang University, Weifang 261061, Shandong Province, China.
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Meng
authors.affiliation: State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao Shandong 266580, China.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao Shandong 266580, China.
authors.forename: Fangna
authors.initials: F
authors.lastname: Dai
authors.affiliation: State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao Shandong 266580, China.
authors.forename: Daofeng
authors.initials: D
authors.lastname: Sun
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006862:Hydrogen Sulfide / Q000032:analysis*; D007854:Lead / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D043942:Nanotubes / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D003505:Cyclodextrins; D005456:Fluorescent Dyes; D008670:Metals; D007854:Lead; D006862:Hydrogen Sulfide