title: Preparation of a novel chitosan-microcapsules/starch blend film and the study of its drug-release mechanism.
abstract: A novel drug delivery system, chitosan-microcapsules/starch blend film for antofloxacin controlled release, was prepared, and characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (X-RD), thermogravimetry and derivative thermogravimetry (TG/DTG), and scanning electron microscopy (SEM). Following incorporation of the chitosan-microcapsules in the film matrix, the synergistic interactions between these drug-carriers were significant. The thermostability and mechanical properties of the blend film were greatly improved by the incorporation of the microcapsules. The water resistance of the blend film was enhanced by increasing the content of microcapsules, indicating that the microcapsules acted as moisture barriers. After being incorporated, chitosan-microcapsules/starch blend film shows a sustained drug release. The extent of the film degradation and microcapsules swelling in the release system indicated that the drug released of the blend film was pH-sensitive. The blend film exhibited pharmacodynamic efficacy because of the efficient drug releasing.
authors.affiliation: College of Materials and Energy, South China Agricultural University, Guangzhou, China.
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Huo
authors.affiliation: College of Materials and Energy, South China Agricultural University, Guangzhou, China.
authors.forename: Gancheng
authors.initials: G
authors.lastname: Xie
authors.affiliation: College of Life Science, South China Agricultural University, Guangzhou, China.
authors.forename: Weixin
authors.initials: W
authors.lastname: Zhang
authors.affiliation: College of Materials and Energy, South China Agricultural University, Guangzhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: College of Materials and Energy, South China Agricultural University, Guangzhou, China.
authors.forename: Junyang
authors.initials: J
authors.lastname: Shan
authors.affiliation: College of Materials and Energy, South China Agricultural University, Guangzhou, China.
authors.forename: Hechou
authors.initials: H
authors.lastname: Liu
authors.affiliation: College of Materials and Energy, South China Agricultural University, Guangzhou, China. Electronic address: xhzhou@scau.edu.cn.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Zhou
mesh_terms: D002021:Buffers; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D055595:Mechanical Phenomena; D015242:Ofloxacin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D010539:Permeability; D013213:Starch / Q000737:chemistry*; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D002021:Buffers; D004337:Drug Carriers; D014867:Water; C522674:antofloxacin; D013213:Starch; D048271:Chitosan; D015242:Ofloxacin
keywords: Chitosan-microcapsules/starch blend film; Drug-release mechanism; Synergistic effect