title: Intensive statin therapy, used alone or in combination with ezetimibe, improves homocysteine level and lipid peroxidation to a similar degree in patients with coronary artery diseases.
abstract: BACKGROUND
  Increase in the concentration of homocysteine is one of the risks of cardiovascular diseases. Coronary artery disease accompanied the increase of LDL cholesterol level and hipolipemic drugs are used in such treatments. Also these drugs have pleiotropic effects, which are not greatly known. The aim of that study is to compare the effect of three different hipolipemic therapies (rosuvastatin 15mg/d; atorvastatin 40mg/d; atorvastatin+ezetymibe 10mg/d+10mg/d) depending upon the concentration of homocysteine and lipid peroxidation in plasma of CAD patients with non-target LDL-cholesterol level.
  
  
  RESULTS
  The study involved 30 healthy subjects as well as 30 patients with angiographically confirmed coronary artery disease who despite at least 6 months hypolipidemic treatment did not achieve LDL-C <70mg/dl. The following parameters studied included homocysteine level, lipid peroxidation in plasma and lipidogram parameters. Our study showed increase of homocysteine level, lipid peroxidation in plasma, LDL-C concentration and total cholesterol level. After six months therapy, the following changes were observed in comparison to the values before therapy: decrease of homocysteine level in plasma - R15 20%, A40 26% and A+E 28%; decrease of lipid peroxidation in plasma - R15 31%, A40 27% and A+E 32%; decrease of LDL-C cholesterol level - R15 18%; A40 17% and A+E 33% and decrease of total cholesterol level - R15 9%, A40 15% and A+E 17%.
  
  
  CONCLUSIONS
  Our results suggest that intensive lipid-lowering therapy has a beneficial effect on certain parameters of the blood of CAD patients.
authors.affiliation: Department of Environment Pollution Biophysics, Faculty of Biology and Environmental Protection, University of Łódź, Łódź, Poland. Electronic address: epytel@biol.uni.lodz.pl.
authors.forename: Edyta
authors.initials: E
authors.lastname: Pytel
authors.affiliation: Department of Internal Diseases and Clinical Pharmacology, Medical University of Łódź, Łódź, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Jackowska
authors.affiliation: Department of Environmental Chemistry, Faculty of Chemistry, University of Łódź, Łódź, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Chwatko
authors.affiliation: Department of Internal Diseases and Clinical Pharmacology, Medical University of Łódź, Łódź, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Olszewska-Banaszczyk
authors.affiliation: Department of Environment Pollution Biophysics, Faculty of Biology and Environmental Protection, University of Łódź, Łódź, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Koter-Michalak
authors.affiliation: Department of Environmental Chemistry, Faculty of Chemistry, University of Łódź, Łódź, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Kubalczyk
authors.affiliation: Department of Internal Diseases and Clinical Pharmacology, Medical University of Łódź, Łódź, Poland.
authors.forename: Marlena
authors.initials: M
authors.lastname: Broncel
mesh_terms: D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D000069059:Atorvastatin / Q000627:therapeutic use; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D000069438:Ezetimibe / Q000627:therapeutic use*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D000068718:Rosuvastatin Calcium / Q000627:therapeutic use
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006710:Homocysteine; D000068718:Rosuvastatin Calcium; D000069059:Atorvastatin; D000069438:Ezetimibe
keywords: Coronary artery disease; Homocysteine; Lipid peroxidation; Plasma lipids