title: Extent of Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in Japanese Hypertrophic Cardiomyopathy Patients.
abstract: BACKGROUND
  In addition to the presence of late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR), the extent of LGE is considered clinically important in hypertrophic cardiomyopathy (HCM). We evaluated the extent of LGE on CMR in a large series of Japanese HCM patients.
  
  
  RESULTS
  CMR was performed in 317 HCM patients (147 male). The extent of LGE was scored as the sum of LGE-positive segments in a left ventricle (LV) 17-segment model. LGE was present in 246 patients (77.6%). LGE was detected in 3.5±3.1 segments on average. When the patients were divided according to maximum wall thickness (mild, <20 mm; moderate, 20-29 mm; severe, ≥30 mm), median LGE score increased as wall thickness increased (mild, 2 vs. moderate, 4 vs. severe, 5; P=0.000). When the patients were divided according to ejection fraction (EF) (reduced, <50%; low-normal, 50-65%; normal, >65%), median LGE score increased as EF decreased (reduced, 7 vs. low-normal, 4 vs. normal, 2; P=0.000). On multivariate analysis, reduced EF (OR, 0.947, P=0.015), pressure gradient <30 mmHg (OR, 0.359, P=0.000) and increased maximum wall thickness (OR, 1.236, P=0.000) were independent factors associated with extensive LGE.
  
  
  CONCLUSIONS
  Progression of LGE was related to increased wall thickness, decreased contractility, and reduced intraventricular pressure gradient.
authors.affiliation: Department of Cardiology, Sakakibara Heart Institute.
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Hen
authors.forename: Nobuo
authors.initials: N
authors.lastname: Iguchi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Utanohara
authors.forename: Kaori
authors.initials: K
authors.lastname: Takada
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Machida
authors.forename: Ayako
authors.initials: A
authors.lastname: Takara
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Teraoka
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Itaru
authors.initials: I
authors.lastname: Takamisawa
authors.forename: Morimasa
authors.initials: M
authors.lastname: Takayama
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D000368:Aged; D044466:Asian People; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage*; D006801:Humans; D007564:Japan; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D005682:Gadolinium