title: Constituents of Fagraea fragrans with Antimycobacterial Activity in Combination with Erythromycin.
abstract: Seven new compounds constituted by three secoiridoids (1-3), two isocoumarins (4 and 5), an iridoid (6), and an aromatic derivative (7) in addition to 24 known compounds were isolated from the stem bark of Fagraea fragrans. The structures of the new compounds were determined on the basis of spectroscopic data analysis. The isolated compounds showed no antibacterial activity against Staphylococcus aureus and Escherichia coli. However, 5-formylisochromen-1-one (4), (-)-mellein (8), and swermacrolactone C (9) exhibited potent antimycobacterial activities against Mycobacterium smegmatis when used in combination with the antibiotic drug erythromycin.
authors.forename: Suwaibah
authors.initials: S
authors.lastname: Madmanang
authors.forename: Naseebah
authors.initials: N
authors.lastname: Cheyeng
authors.forename: Sareefah
authors.initials: S
authors.lastname: Heembenmad
authors.forename: Wilawan
authors.initials: W
authors.lastname: Mahabusarakam
authors.forename: Jongkon
authors.initials: J
authors.lastname: Saising
authors.affiliation: University of Zurich, Institute of Medical Microbiology , Gloriastrasse 30/32 CH-8006 Zurich, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Seeger
authors.forename: Sasitorn
authors.initials: S
authors.lastname: Chusri
authors.forename: Suda
authors.initials: S
authors.lastname: Chakthong
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004917:Erythromycin / Q000494:pharmacology*; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013785:Thailand
chemical_list: C000610265:5-formylisochromen-1-one; D000900:Anti-Bacterial Agents; D039823:Iridoids; D049934:Isocoumarins; C000610266:fraganal; D004917:Erythromycin