title: Efficacy of a New Heparan Sulfate Mimetic Dressing in the Healing of Foot and Lower Extremity Ulcerations in Type 2 Diabetes: A Case Series.
abstract: A novel heparan sulfate glycosaminoglycan mimetic product for local application to promote wound healing (CACIPLIQ) has recently become available. It is a biophysical therapeutic product comprising a polysaccharide as an innovative biomaterial to accomplish mechanical tissue engineering and skin regeneration in the site of ulceration. We present a series of 12 patients with type 2 diabetes (4 men and 8 women; age 53-87 years; diabetes duration 8-25 years) having chronic resistance to therapy for foot and lower extremity ulcerations. CACIPLIQ was locally applied twice per week after careful debridement. Complete ulcer healing was accomplished in all patients after a mean treatment duration of 4.92 months (range = 2-12 months). The product was very well tolerated. In conclusion, these results, although preliminary, are encouraging and suggest adequate efficacy and safety of the new product in difficult-to-heal foot and lower extremity ulcerations in type 2 diabetes.
authors.affiliation: Democritus University of Thrace, Alexandroupolis, Greece papanasnikos@yahoo.gr.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papanas
authors.affiliation: National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Costas
authors.initials: C
authors.lastname: Demetzos
authors.affiliation: National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Natassa
authors.initials: N
authors.lastname: Pippa
authors.affiliation: Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: Efstratios
authors.initials: E
authors.lastname: Maltezos
authors.affiliation: National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Tentolouris
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D017719:Diabetic Foot / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006497:Heparan Sulfate / Q000627:therapeutic use*; D006801:Humans; D007871:Leg Ulcer / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D006497:Heparan Sulfate
keywords: biomimetic scaffold; diabetic foot; dressing; hydration; tissue engineering; ulceration