title: Shared links between type 2 diabetes mellitus and Alzheimer's disease: A review.
abstract: Epidemiological studies have proved that, there are pathophysiological connections between Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD). Diabetic patients have higher incidences of cognitive impairment and hence they are more at the risk of developing AD. Some of the recent evidences have majorly stated the effects of insulin resistance in the disturbance of various biological processes and signaling pathways. Both hyperglycemia and hypoglycemic conditions contributes in dysfunctioning of cognitive abilities and functions. The present review summarizes the evidences which establish the possible links between the two pathologies on the account of molecular, biochemical and at histopathological level. The information regarding their interactions was collected from different databases and journals. The gathered information will clearly establish the link among the two pathologies and will be helpful in future for the development of drugs for Type 3 Diabetes.
authors.affiliation: Proteomics and Translational Research Lab, Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.
authors.forename: Khyati
authors.initials: K
authors.lastname: Mittal
authors.affiliation: Proteomics and Translational Research Lab, Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India. Electronic address: dpkatare@amity.edu.
authors.forename: Deepshikha Pande
authors.initials: DP
authors.lastname: Katare
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance; D008958:Models, Molecular; D018384:Oxidative Stress; D015398:Signal Transduction
keywords: Alzheimer's disease; Shared links; Type 2 diabetes mellitus; Type 3 diabetes