title: Signaling at the Golgi: sensing and controlling the membrane fluxes.
abstract: Over the past few decades, it has emerged that the Golgi (and other secretory stations) is host to a variety of signaling molecules and can act as a signaling hub that receives, emits and elaborates signals. This endomembrane-based signaling apparatus appears to have more than one purpose. Its most fundamental function appears to be the auto-regulation of the biosynthetic apparatus to maintain and/or optimize its own activities and to coordinate such activities with those of other cellular modules.(1) This is achieved by dedicated control devices that provide stability, robustness, precision, sensitivity and complexity to cellular behaviors.
authors.affiliation: Institute of Protein Biochemistry, National Research Council, Via P. Castellino 111, 80131 Naples, Italy; Istituto di Ricovero e Cura a Carattere Scientifico SDN, Via Emanuele Gianturco, 113, 80143 Naples, Italy. Electronic address: a.luini@ibp.cnr.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Luini
authors.affiliation: Institute of Protein Biochemistry, National Research Council, Via P. Castellino 111, 80131 Naples, Italy.
authors.forename: Seetharaman
authors.initials: S
authors.lastname: Parashuraman
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D011506:Proteins