title: A Case Series of Patients With Autoimmune Myasthenia Gravis in Association With Invasive Thymoma.
abstract: OBJECTIVE
  In some patients, autoimmune myasthenia gravis (MG) is associated with thymic hyperplasia or thymoma, and in some patients the thymoma is invasive. Little is known about the clinical course of subjects who present with MG and are found to have invasive thymoma.
  
  
  METHODS
  We reviewed the patients at our clinic with MG and invasive thymoma, and have described their clinical features.
  
  
  RESULTS
  Six MG patients were diagnosed with invasive thymoma. The subjects had extensive multimodal therapy. Two subjects died from uncontrolled neuromuscular respiratory failure despite aggressive immunosuppression, 2 subjects had other autoimmune disorders (Morvan syndrome and polymyositis), and 2 subjects are controlled on immunosuppression.
  
  
  CONCLUSIONS
  Patients with invasive thymoma and MG can have a poor outcome, with difficulty in controlling myasthenic symptoms and can have other clinically important autoimmune diseases.
authors.affiliation: *The University of Queensland Centre for Clinical Research and Department of Neurology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia; and †Department of Neurology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
authors.forename: Pamela
authors.initials: P
authors.lastname: McCombe
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Raj
authors.forename: Robert
authors.initials: R
authors.lastname: Henderson
authors.forename: Stefan
authors.initials: S
authors.lastname: Blum
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications* / Q000276:immunology; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology; D011878:Radiotherapy; D011950:Receptors, Cholinergic / Q000276:immunology; D013945:Thymoma / Q000150:complications* / Q000276:immunology / Q000628:therapy; D013953:Thymus Neoplasms / Q000150:complications* / Q000276:immunology / Q000628:therapy
chemical_list: D000906:Antibodies; D024642:Potassium Channels, Voltage-Gated; D011950:Receptors, Cholinergic