title: A contact-lens-on-a-chip companion diagnostic tool for personalized medicine.
abstract: We present a novel, microfluidic platform that integrates human tears (1 μL) with commercial contact lens materials to provide personalized assessment of lens care solution performance. This device enabled the detection of significant differences in cleaning and disinfection outcomes between subjects and between biofilms vs. planktonic bacteria.
authors.affiliation: Department of Biomedical Engineering, The George Washington University, 800 22nd Street NW, Washington, DC 20052, USA. zhenyu@gwu.edu.
authors.forename: Allan
authors.initials: A
authors.lastname: Guan
authors.affiliation: Division of Biology, Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. Kenneth.Phillips@fda.hhs.gov.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Division of Biology, Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. Kenneth.Phillips@fda.hhs.gov.
authors.forename: K Scott
authors.initials: KS
authors.lastname: Phillips
authors.affiliation: Department of Biomedical Engineering, The George Washington University, 800 22nd Street NW, Washington, DC 20052, USA. zhenyu@gwu.edu.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Li
mesh_terms: D001419:Bacteria; D018441:Biofilms; D003261:Contact Lenses / Q000382:microbiology*; D004203:Disinfection / Q000379:methods*; D006801:Humans; D056656:Lab-On-A-Chip Devices; D010933:Plankton; D057285:Precision Medicine / Q000295:instrumentation* / Q000379:methods*; D013666:Tears / Q000737:chemistry*