title: Evaluation of drug-carrier interactions in quaternary powder mixtures containing perindopril tert-butylamine and indapamide.
abstract: Interactions occurring between components in the quaternary powder mixtures consisting of perindopril tert-butylamine, indapamide (active pharmaceutical ingredients), carrier substance and hydrophobic colloidal silica were examined. Two grades of lactose monohydrate: Spherolac(®) 100 and Granulac(®) 200 and two types of microcrystalline cellulose: M101D+ and Vivapur(®) 102 were used as carriers. We determined the size distribution (laser diffraction method), morphology (scanning electron microscopy) and a specific surface area of the powder particles (by nitrogen adsorption-desorption). For the determination of the surface energy of powder mixtures the method of inverse gas chromatography was applied. Investigated mixtures were characterized by surface parameters (dispersive component of surface energy, specific interactions parameters, specific surface area), work of adhesion and cohesion as well as Flory-Huggins parameter χ23('). Results obtained for all quaternary powder mixtures indicate existence of interactions between components. The strongest interactions occur for both blends with different types of microcrystalline cellulose (PM-1 and PM-4) while much weaker ones for powder mixtures with various types of lactose (PM-2 and PM-3).
authors.affiliation: Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, Poland. Electronic address: Adam.Voelkel@put.poznan.pl.
authors.forename: Adam
authors.initials: A
authors.lastname: Voelkel
authors.affiliation: Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, Poland. Electronic address: Kasylda.Milczewska@put.poznan.pl.
authors.forename: Kasylda
authors.initials: K
authors.lastname: Milczewska
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland; Gedeon Richter Polska Sp. z o.o., 5 Ks. J. Poniatowskiego Street, 05-825 Grodzisk Mazowiecki, Poland. Electronic address: mtezyk@grodzisk.rgnet.org.
authors.forename: Michał
authors.initials: M
authors.lastname: Teżyk
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland. Electronic address: bmilan@ump.edu.pl.
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Milanowski
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland. Electronic address: jlulek@ump.edu.pl.
authors.forename: Janina
authors.initials: J
authors.lastname: Lulek
mesh_terms: D002482:Cellulose / Q000737:chemistry; D002849:Chromatography, Gas; D004337:Drug Carriers / Q000737:chemistry*; D007190:Indapamide / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry; D020913:Perindopril / Q000737:chemistry*; D011208:Powders; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D011208:Powders; D012822:Silicon Dioxide; D002482:Cellulose; D007190:Indapamide; D007785:Lactose; C109691:microcrystalline cellulose; D020913:Perindopril
keywords: Flory-Huggins parameter; Indapamide; Inverse gas chromatography; Perindopril; Quaternary powder mixtures; Surface properties; Work of adhesion