title: Interleukin-33 Expression Indicates a Favorable Prognosis in Malignant Salivary Gland Tumors.
abstract: The cytokine interleukin-33 (IL-33) is abundantly expressed in epithelial barrier tissues such as salivary glands. Here, we characterized nuclear IL-33 protein expression by immunohistochemistry in benign and malignant salivary gland tumors and associated it with disease outcome. Most benign salivary gland tumors expressed IL-33, and all Warthin's tumors showed strong and consistent IL-33 expression in the basally oriented cells of their bilayered epithelium. In the malignant group of neoplasms, nuclear IL-33 expression was limited to specific tumor entities-for example, to epithelial-myopepithelial carcinomas (n = 9/11), acinic cell carcinomas (n = 13/27), and oncocytic carcinomas (n = 2/2). IL-33 expression in the combined group of malignant salivary gland neoplasms was significantly associated with favorable histological parameters, lack of metastasis, and longer overall survival, compared with IL-33-negative tumors. We conclude that IL-33 expression is a novel prognostic marker for malignant salivary gland tumors with potential use in clinical diagnostics.
authors.affiliation: Institute of Pathology, Cantonal Hospital of Grisons, Chur, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Rössle
authors.affiliation: Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland.
authors.forename: Gieri
authors.initials: G
authors.lastname: Cathomas
authors.affiliation: Novartis Institute for Biomedical Research, Basel, Switzerland.
authors.forename: Laura
authors.initials: L
authors.lastname: Bonapace
authors.affiliation: Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland.
authors.forename: Melanie
authors.initials: M
authors.lastname: Sachs
authors.affiliation: Cantonal Cancer Registry Zürich-Zug, Zürich, Switzerland.
authors.forename: Silvia
authors.initials: S
authors.lastname: Dehler
authors.affiliation: Institute of Surgical Pathology, University Hospital Zürich, Zürich, Switzerland.
authors.forename: Martina
authors.initials: M
authors.lastname: Storz
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zürich, Zürich, Switzerland.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Huber
authors.affiliation: Institute of Surgical Pathology, University Hospital Zürich, Zürich, Switzerland.
authors.forename: Holger
authors.initials: H
authors.lastname: Moch
authors.affiliation: Novartis Institute for Biomedical Research, Basel, Switzerland.
authors.forename: Tobias
authors.initials: T
authors.lastname: Junt
authors.affiliation: Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland kirsten.mertz@ksbl.ch.
authors.forename: Kirsten D
authors.initials: KD
authors.lastname: Mertz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D000067596:Interleukin-33 / Q000032:analysis / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C506536:IL33 protein, human; D000067596:Interleukin-33
keywords: biomarker; immunohistochemistry; interleukin-33; prognosis; salivary gland; tissue microarray