title: Targeting Cancer Stem Cells in Oral Cancer.
abstract: The concept of tumor development driven by a unique subpopulation of cancer stem cells (CSCs), or the CSCs hypothesis, may help to explain the high mortality, low response to treatment and tendency of developing multiple tumors in oral cancer. We will review current knowledge of the CSCs hypothesis in oral cancer and the traits displayed by CSCs, focusing on the resistance to therapy and attempts being made to treat oral cancer by specifically targeting CSCs.
authors.forename: Qilin
authors.initials: Q
authors.lastname: Xu
authors.forename: Anh D
authors.initials: AD
authors.lastname: Le
mesh_terms: D063646:Carcinogenesis / Q000473:pathology; D002470:Cell Survival / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009062:Mouth Neoplasms / Q000473:pathology*; D009362:Neoplasm Metastasis; D014411:Neoplastic Stem Cells / Q000145:classification / Q000502:physiology*; D011836:Radiation Tolerance