title: Birth and upgrowth of the Hox topological domains during evolution.
abstract: The recently discovered chromatin compartments called topologically associating domains (TADs) are essential for the three-dimensional organization of regulatory interactions driving gene expression. A new study documents the emergence of a TAD flanking the amphioxus Hox cluster, prefiguring the vertebrate anterior Hox TAD and preceding the appearance of the concurring posterior Hox TAD.
authors.affiliation: Hubrecht Institute, Developmental Biology and Stem Cell Research, Utrecht, the Netherlands.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Deschamps
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D019143:Evolution, Molecular; D018398:Homeodomain Proteins / Q000096:biosynthesis*; D064175:Lancelets / Q000235:genetics*
chemical_list: D018398:Homeodomain Proteins