title: Multigrowth Factor Delivery via Immobilization of Gene Therapy Vectors.
abstract: Molecules can be immobilized onto biomaterials by a chemical vapor deposition (CVD) coating strategy. Pentafluorophenolester groups react with amine side chains on antibodies, which can selectively immobilize adenoviral vectors for gene delivery of growth factors. These vectors can produce functional proteins within defined regions of biomaterials to produce customizable structures for targeted tissue regeneration.
authors.affiliation: Periodontics and Oral Medicine, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Hao
authors.affiliation: Biointerfaces Institute, Department of Materials Science and Engineering, B26-115S NCRC, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109-2800, USA.
authors.forename: Kenneth C K
authors.initials: KC
authors.lastname: Cheng
authors.affiliation: Periodontics and Oral Medicine, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA.
authors.forename: Laura G
authors.initials: LG
authors.lastname: Kruger
authors.affiliation: Periodontics and Oral Medicine, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA.|Department of Periodontology, Institute of Odontology, Medicinaregatan 12F, 6th Floor, University of Gothenburg, SE-405 30 Gothenburg, Sweden.
authors.forename: Lena
authors.initials: L
authors.lastname: Larsson
authors.affiliation: Periodontics and Oral Medicine, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA.
authors.forename: James V
authors.initials: JV
authors.lastname: Sugai
authors.affiliation: Biointerfaces Institute, Department of Chemical Engineering, Materials Science and Engineering, Biomedical Engineering, Macromolecular Science and Engineering, B10-A175 NCRC, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109-2800, USA.
authors.forename: Joerg
authors.initials: J
authors.lastname: Lahann
authors.affiliation: Department of Periodontics and Oral Medicine and Department of Biomedical Engineering, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA.
authors.forename: William V
authors.initials: WV
authors.lastname: Giannobile
mesh_terms: D000256:Adenoviridae / Q000235:genetics* / Q000276:immunology; D055910:Antibodies, Immobilized / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D002478:Cells, Cultured; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics / Q000276:immunology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis / Q000235:genetics*; D010513:Periodontal Ligament / Q000166:cytology; D044968:Regenerative Medicine / Q000379:methods; D014945:Wound Healing
chemical_list: D055910:Antibodies, Immobilized; D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins
keywords: bone morphogenetic proteins; drug delivery; gene transfer; platelet-derived growth factor; regenerative medicine; tissue regeneration