title: Beneficial effects of a red wine polyphenol extract on high-fat diet-induced metabolic syndrome in rats.
abstract: OBJECTIVE
  Individuals with metabolic syndrome (MS) show several metabolic abnormalities including insulin resistance, dyslipidaemia, and oxidative stress (OS). Diet is one of the factors influencing the development of MS, and current nutritional advice emphasises the benefits of fruit and vegetable consumption. Here, we assessed the effects of naturally occurring antioxidants, red wine polyphenols (RWPs), on MS and OS.
  
  
  METHODS
  Wistar rats (n = 20) weighing 200-220 g received a high-fat diet (HFD) for 2 months before they were divided into two groups that received either HFD only or HFD plus 50 mg/kg RWPs in their drinking water for an additional 2 months. A control group (n = 10) received a normal diet (ND) for 4 months.
  
  
  RESULTS
  Rats receiving HFD increased body weight over 20 % throughout the duration of the study. They also showed increased blood levels of C-peptide, glucose, lipid peroxides, and oxidised proteins. In addition, the HFD increased OS in hepatic, pancreatic, and vascular tissues, as well as induced pancreatic islet cell hyperplasia and hepatic steatosis. Addition of RWPs to the HFD attenuated these effects on plasma and tissue OS and on islet cell hyperplasia. However, RWPs had no effect on blood glucose levels or hepatic steatosis.
  
  
  CONCLUSIONS
  RWPs showed an antioxidant mechanism of action against MS. This result will inform future animal studies exploring the metabolic effects of RWPs in more detail. In addition, these findings support the use of antioxidants as adjunctive nutritional treatments for patients with diabetes.
authors.affiliation: UMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bld René Leriche, 67200, Strasbourg, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Auberval
authors.affiliation: UMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bld René Leriche, 67200, Strasbourg, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Dal
authors.affiliation: UMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bld René Leriche, 67200, Strasbourg, France.
authors.forename: Elisa
authors.initials: E
authors.lastname: Maillard
authors.affiliation: UMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bld René Leriche, 67200, Strasbourg, France.
authors.forename: William
authors.initials: W
authors.lastname: Bietiger
authors.affiliation: UMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bld René Leriche, 67200, Strasbourg, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Peronet
authors.affiliation: UMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bld René Leriche, 67200, Strasbourg, France.|UMR 7175 CNRS, Pharmacologie et Physico-Chimie, Faculté de Pharmacie, Université de Strasbourg, 67400, Illkirch, France.|Departement d'Endocrinologie, Diabète, Maladies Métaboliques, Pôle NUDE, Hôpitaux Universitaires de Strasbourg, (HUS), 67000, Strasbourg, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Pinget
authors.affiliation: UMR 7175 CNRS, Pharmacologie et Physico-Chimie, Faculté de Pharmacie, Université de Strasbourg, 67400, Illkirch, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Schini-Kerth
authors.affiliation: UMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bld René Leriche, 67200, Strasbourg, France. s.sigrist@ceed-diabete.org.
authors.forename: Séverine
authors.initials: S
authors.lastname: Sigrist
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects*; D004195:Disease Models, Animal; D008054:Lipid Peroxides / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000178:diet therapy*; D018384:Oxidative Stress / Q000187:drug effects; D059808:Polyphenols / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014920:Wine
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D002096:C-Peptide; D008054:Lipid Peroxides; D059808:Polyphenols
keywords: High-fat-diet rats; Metabolic syndrome; Oxidative stress; Red wine polyphenols