title: Fasting serum insulin levels and insulin resistance are associated with blood rheology in Japanese young adults without diabetes.
abstract: OBJECTIVE
  To evaluate fasting serum insulin levels and insulin resistance, and their association with blood rheology, in Japanese young adults without diabetes.
  
  
  METHODS
  Blood samples were analysed and blood rheology was estimated using haematological parameters. Whole blood passage time was measured using a Hitachi MC-FAN(©) microchannel array flow analyser.
  
  
  RESULTS
  Out of 151 subjects (mean age, 24.1 ± 1.5 years), fasting serum insulin levels and insulin resistance (using homeostasis model assessment-estimated insulin resistance [HOMA-IR]), were positively correlated with longer whole blood passage times and higher values for haematocrit (Hct), haemoglobin (Hb), fibrinogen, body weight, body mass index (BMI), triglycerides, and low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio, and were negatively correlated with HDL-C. Whole blood passage time correlated with body weight, BMI, LDL-C/HDL-C ratio, Hct, Hb, white blood cell (WBC) count, platelet count, fibrinogen, fasting serum insulin levels, and HOMA-IR. Multiple regression analysis revealed that whole blood passage time was independently associated with Hct, fibrinogen levels, and WBC count.
  
  
  CONCLUSIONS
  Fasting serum insulin levels and insulin resistance were associated with blood rheology, and may influence blood rheology by modulating haematological parameters and lipid parameters in young adults without diabetes.
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan tkimura@gunma-u.ac.jp.
authors.forename: Takao
authors.initials: T
authors.lastname: Kimura
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Aoki
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Tsunekawa
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Araki
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Shoho
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nara
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sumino
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Murakami
mesh_terms: D000328:Adult; D044466:Asian People; D003710:Demography; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005215:Fasting / Q000097:blood*; D005260:Female; D018056:Hemorheology; D006801:Humans; D007333:Insulin Resistance; D016014:Linear Models; D008297:Male; D055815:Young Adult
keywords: Insulin; blood rheology; fibrinogen; haematocrit; insulin resistance