title: Tissue-resident dendritic cells and diseases involving dendritic cell malfunction.
abstract: Dendritic cells (DCs) control immune responses and are central to the development of immune memory and tolerance. DCs initiate and orchestrate immune responses in a manner that depends on signals they receive from microbes and cellular environment. Although DCs consist mainly of bone marrow-derived and resident populations, a third tissue-derived population resides the spleen and lymph nodes (LNs), different subsets of tissue-derived DCs have been identified in the blood, spleen, lymph nodes, skin, lung, liver, gut and kidney to maintain the tolerance and control immune responses. Tissue-resident DCs express different receptors for microbe-associated molecular patterns (MAMPs) and damage-associated molecular patterns (DAMPs), which were activated to promote the production of pro- or anti-inflammatory cytokines. Malfunction of DCs contributes to diseases such as autoimmunity, allergy, and cancer. It is therefore important to update the knowledge about resident DC subsets and diseases associated with DC malfunction.
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Laboratory of Inflammation Biology, Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0910, USA. Electronic address: keqiangc8@gmail.com.
authors.forename: Keqiang
authors.initials: K
authors.lastname: Chen
authors.affiliation: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Electronic address: wangji@mail.nih.gov.
authors.forename: Ji Ming
authors.initials: JM
authors.lastname: Wang
authors.affiliation: Laboratory of Inflammation Biology, Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0910, USA.
authors.forename: Ruoxi
authors.initials: R
authors.lastname: Yuan
authors.affiliation: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
authors.forename: Xiang
authors.initials: X
authors.lastname: Yi
authors.affiliation: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
authors.forename: Liangzhu
authors.initials: L
authors.lastname: Li
authors.affiliation: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Basic Research Program, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
authors.forename: Wanghua
authors.initials: W
authors.lastname: Gong
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
authors.forename: Tianshu
authors.initials: T
authors.lastname: Yang
authors.affiliation: Laboratory of Inflammation Biology, Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0910, USA.
authors.forename: Liwu
authors.initials: L
authors.lastname: Li
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
authors.forename: Shaobo
authors.initials: S
authors.lastname: Su
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000637:transplantation; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000628:therapy; D007108:Immune Tolerance; D007156:Immunologic Memory; D007167:Immunotherapy / Q000379:methods*; D018836:Inflammation Mediators / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D051192:Receptors, Pattern Recognition / Q000378:metabolism
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D051192:Receptors, Pattern Recognition
keywords: Autoimmunity; Cancer; DC-related diseases; Dendritic cells; Resident DCs