title: [CLINICAL, ENDOSCOPIC AND MORPHOLOGICAL FEATURES OF GASTROESOPHAGEAL REFLUX DISEASE IN PATIENTS WITH CERTAIN SURGICAL DISEASES OF THE UPPER GASTROINTESTINAL TRACT].
abstract: OBJECTIVE
  To reveal the peculiarities of manifestations and treatment of gastroesophageal reflux disease (GERD) in patients with peptic ulcer disease of the stomach and duodenum, hiatal hernia (HH) and after stomach resection.
  
  
  METHODS
  387 patients with GERD, peptic ulcer disease of the stomach and duodenum (200 patients), after resection of the stomach Billroth II (150 patients), 37 patients with HH. Videoendoscopic equipment company OLYMPUS (Japan) was used. Biopsies of the mucous membranes of the pylorus, body, angle of the stomach and esophagus were studied to identify preneoplastic changes. HP was determined histologically, cytologically, urease tests.
  
  
  RESULTS
  The patients with GERD and peptic ulcer disease of the stomach and duodenum were complained on the heartburn, the patients after resection of the stomach--on feeling bitterness in the mouth, with HH--on the pain behind the breastbone. More severe degree of GERD (C and D) was endoscopic feature in patients with HH and A degree or endoscopic negative form--after resection of the stomach. Preneoplastic changes of the esophageal mucosa with columnar epithelium were found in cases of less severe degrees of inflammation. The degree of esophagitis, presence of preneoplastic changes were determined depending on the presence of Helicobacter pylori. Antireflux surgery was performed under strict indications.
  
  
  CONCLUSIONS
  Clinical features, endoscopic, morphological manifestations of GERD in patients with pectic ulcer disease of the stomach and duodenum, with resection of the stomach and patients with HH were determined. This is dictated the individual differentiated approach to the choice of the treatment.
authors.forename: O B
authors.initials: OB
authors.lastname: Dronova
authors.forename: E V
authors.initials: EV
authors.lastname: Kolesnikova
authors.forename: A A
authors.initials: AA
authors.lastname: Tretjakov
authors.forename: S V
authors.initials: SV
authors.lastname: Petrov
authors.forename: A F
authors.initials: AF
authors.lastname: Schetinin
authors.forename: A N
authors.initials: AN
authors.lastname: Neverov
mesh_terms: D000328:Adult; D004381:Duodenal Ulcer / Q000150:complications / Q000473:pathology / Q000601:surgery; D004945:Esophagoscopy; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000150:complications / Q000473:pathology / Q000601:surgery