title: Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response.
abstract: The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeastSaccharomyces cerevisiaewere isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview.
authors.affiliation: From the Division of Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Alvaro
authors.affiliation: From the Division of Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202 jthorner@berkeley.edu.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Thorner
mesh_terms: D004271:DNA, Fungal / Q000235:genetics; D015966:Gene Expression Regulation, Fungal; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D010675:Pheromones / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D043563:Receptors, Pheromone / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D004271:DNA, Fungal; D010675:Pheromones; D043562:Receptors, G-Protein-Coupled; D043563:Receptors, Pheromone; D029701:Saccharomyces cerevisiae Proteins; D020962:Heterotrimeric GTP-Binding Proteins
keywords: G protein; G protein-coupled receptor (GPCR); Saccharomyces cerevisiae; adaptor protein; cell adhesion; cell cycle arrest; cell differentiation; cell fusion; gene regulation; mitogen-activated protein kinase (MAPK); morphogenesis; nuclear fusion; polarized morphogenesis; post-translational modification (PTM); protein phosphorylation; scaffold protein; signal transduction