title: Evaluation of platelet-rich plasma and fibrin matrix to assist in healing and repair of rotator cuff injuries: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To perform a meta-analysis examining the effectiveness of platelet-rich plasma and platelet-rich fibrin matrix for improving healing of rotator cuff injuries. Data sources/design: A meta-analysis of eligible studies was performed after searching Medline, Cochrane, and EMBASE on 14 December 2015.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Patients with rotator cuff injuries. Review methods/intervention: Databases were searched using the keywords "PRP or platelet-rich plasma," "PRFM or platelet-rich fibrin matrix," "rotator cuff," and "platelet-rich" for studies comparing outcomes of patients with rotator cuff injuries that did and did not receive a platelet-rich product.
  
  
  METHODS
  The primary outcome was a functional score change from pre- to post-treatment (Scorepost-Scorepre). The secondary outcome was a visual analogue scale (VAS) pain score change from pre- to post-treatment (VASpost-VASpre).
  
  
  RESULTS
  A total of 11 studies were included in the meta-analysis. The total number of patients that received platelet-rich plasma or platelet-rich fibrin matrix was 320 and the number of control patients was 318. The standard difference in means of the functional scores was similar between patients administered platelet-rich plasma/fibrin matrix and patients in the control group (standard difference in means for functional scores = 0.029; 95% confidence interval (CI): -0.132 to 0.190; p = 0.725). The standard difference in means was similar between patients administered platelet-rich plasma and the controls (standard difference in means = 0.142; 95% CI: -0.080 to 0.364; p = 0.209).
  
  
  CONCLUSIONS
  The results of this meta-analysis do not support the use of platelet-rich plasma/platelet-rich fibrin matrix in patients with rotator cuff injuries.
authors.affiliation: Department of Orthopedics, Harbin Medical University, Harbin, China.
authors.forename: Chun-Jiang
authors.initials: CJ
authors.lastname: Fu
authors.affiliation: Department of Orthopedics, Harbin Medical University, Harbin, China.
authors.forename: Jia-Bing
authors.initials: JB
authors.lastname: Sun
authors.affiliation: Department of Orthopedics, Harbin Medical University, Harbin, China.
authors.forename: Zheng-Gang
authors.initials: ZG
authors.lastname: Bi
authors.affiliation: Department of Orthopedics, Harbin Medical University, Harbin, China.
authors.forename: Xu-Ming
authors.initials: XM
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, Harbin Medical University, Harbin, China.
authors.forename: Cheng-Lin
authors.initials: CL
authors.lastname: Yang
mesh_terms: D001182:Arthroscopy / Q000379:methods; D003131:Combined Modality Therapy; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D053657:Platelet-Rich Plasma; D016032:Randomized Controlled Trials as Topic; D020127:Recovery of Function; D018570:Risk Assessment; D000070636:Rotator Cuff Injuries / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D005337:Fibrin
keywords: Platelet; fibrin; healing; plasma; repair; rotator cuff