title: [Association between IGF system and PAPP-A in coronary atherosclerosis].
abstract: Atherosclerosis is a condition that involves multiple pathophysiological mechanisms and whose knowledge has not been fully elucidated. Often, scientific advances on the atherogenic pathophysiology generate that molecules not previously considered in the scene of this disease, were attributed actions on the onset or progression of it. A representative example is the study of a new mechanism involved in the atherogenic process, consisting of the association between the insulin-like growth factor (IGF) system and pregnancy-associated plasma protein-A (PAPP-A). Insulin-like growth factor system is a family of peptides that include 3 peptide hormones, 4 transmembrane receptors and 6 binding proteins. Insulin-like growth factor-1 (IGF-1) is the main ligand of the IGF system involved in coronary atherosclerosis. IGF-1 exerts its effects via activation of the IGF-1R receptor on vascular smooth muscle cells or macrophages. In vascular smooth muscle cells promotes migration and prevents apoptosis which increases plaque stability while in macrophages reduces reverse cholesterol transport leading to the formation of foam cells. Regulation of IGF-1 endothelial bioavailability is carried out by IGFBP proteases, mainly by PAPP-A. In this review, we address the mechanisms between IGF system and PAPP-A in atherosclerosis with emphasis on molecular effects on vascular smooth muscle cells and macrophages.
authors.affiliation: Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México, DF, México. Electronic address: fierromacias@hotmail.com.
authors.forename: Alfonso Eduardo
authors.initials: AE
authors.lastname: Fierro-Macías
authors.affiliation: Laboratorio Multidisciplinario de Investigación, Escuela Militar de Graduados de Sanidad, Secretaría de la Defensa Nacional (SEDENA), México, DF, México.
authors.forename: Esaú
authors.initials: E
authors.lastname: Floriano-Sánchez
authors.affiliation: Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México, DF, México.
authors.forename: Victoria Michelle
authors.initials: VM
authors.lastname: Mena-Burciaga
authors.affiliation: Departamento de Hemodinamia, Hospital Central Militar, Secretaría de la Defensa Nacional (SEDENA), México, DF, México.
authors.forename: Hugo
authors.initials: H
authors.lastname: Gutiérrez-Leonard
authors.affiliation: Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México, DF, México.
authors.forename: Eleazar
authors.initials: E
authors.lastname: Lara-Padilla
authors.affiliation: Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México, DF, México.
authors.forename: Edgar
authors.initials: E
authors.lastname: Abarca-Rojano
authors.affiliation: Departamento de Cirugía, Hospital General Regional N.(o) 66, Instituto Mexicano del Seguro Social (IMSS), Ciudad Juárez, Chihuahua, México.
authors.forename: Alfonso Edmundo
authors.initials: AE
authors.lastname: Fierro-Almanzán
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000209:etiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D011266:Pregnancy-Associated Plasma Protein-A / Q000502:physiology*
chemical_list: D007334:Insulin-Like Growth Factor I; D011266:Pregnancy-Associated Plasma Protein-A
keywords: Aterosclerosis; Atherosclerosis; Factor de crecimiento similar a la insulina tipo 1; Insulin-like growth factor binding proteins; Insulin-like growth factor system; Insulin-like growth factor-1; Mexico; México; Pregnancy-associated plasma protein-A; Proteína plasmática A asociada al embarazo; Proteínas de unión a factor de crecimiento similar a la insulina; Sistema de factores de crecimiento similares a la insulina