title: Selective, non-covalent conjugation of synthetic peptides with recombinant proteins mediated by host-guest chemistry.
abstract: The combination of potent chemical moieties with biologically active proteins is key to some of today's most innovative therapeutic drugs. In order to obviate any chemical modification of the proteins, we present a novel and powerful strategy for the selective conjugation of recombinant protein domains with synthetically derived peptides via a cucurbit[8]uril host-guest chemistry approach.
authors.affiliation: Formulation Sciences, MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK. wallec@medimmune.com.
authors.forename: R J
authors.initials: RJ
authors.lastname: Gubeli
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. oas23@cam.ac.uk.
authors.forename: S
authors.initials: S
authors.lastname: Sonzini
authors.affiliation: Formulation Sciences, MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK. wallec@medimmune.com.
authors.forename: A
authors.initials: A
authors.lastname: Podmore
authors.affiliation: Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK.
authors.forename: P
authors.initials: P
authors.lastname: Ravn
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. oas23@cam.ac.uk.
authors.forename: O A
authors.initials: OA
authors.lastname: Scherman
authors.affiliation: Formulation Sciences, MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK. wallec@medimmune.com.
authors.forename: C F
authors.initials: CF
authors.lastname: van der Walle
mesh_terms: D010455:Peptides / Q000737:chemistry*; D011994:Recombinant Proteins / Q000737:chemistry
chemical_list: D010455:Peptides; D011994:Recombinant Proteins