title: Synthesis of 2-(methylsulfonyl)-5-(4-(methylsulfonyl) phenyl)-4-phenyl-1H-[5-(14)C]imidazole, a selective COX-2 inhibitor, via asymmetrical benzoins.
abstract: 4,5-Diarylimidazoles labeled with carbon-14 in the 5-position of the imidazole ring were prepared as a part of three-step sequence from 2-hydroxy-1-(4-(methylthio)phenyl)-2-phenyl[1-(14) C]ethanone as a key synthetic intermediate which has been synthesized from potassium [(14) C]cyanide.
authors.affiliation: Nuclear Science Research School, Nuclear Science and Technology Research Institute, End of North Karegar Ave, 14395-836, Tehran, Iran.
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Shirvani
authors.affiliation: Faculty of Chemistry, Kharazmi University (formerly Tarbiat Moallem University), 49 Mofetteh Avenue, 15719-14911, Tehran, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Shockravi
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design Development Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Amini
authors.affiliation: Nuclear Science Research School, Nuclear Science and Technology Research Institute, End of North Karegar Ave, 14395-836, Tehran, Iran.
authors.forename: Nader
authors.initials: N
authors.lastname: Saemian
mesh_terms: D001573:Benzoin / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D052246:Cyclooxygenase 2 Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry*; D015195:Drug Design; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: C000613193:2-(methylsulfonyl)-5-(4-(methylsulfonyl)phenyl)-4-phenyl-1H-imidazole; D052246:Cyclooxygenase 2 Inhibitors; D007093:Imidazoles; D013450:Sulfones; D051546:Cyclooxygenase 2; D001573:Benzoin
keywords: 4,5-diarylimidazole; asymmetrical benzoins; carbon-14; selective COX-2 inhibitors