title: Correlation of iron deposition and change of gliocyte metabolism in the basal ganglia region evaluated using magnetic resonance imaging techniques: an in vivo study.
abstract: BACKGROUND
  We assessed the correlation between iron deposition and the change of gliocyte metabolism in healthy subjects' basal ganglia region, by using 3D-enhanced susceptibility weighted angiography (ESWAN) and proton magnetic resonance spectroscopy ((1)H-MRS).
  
  
  METHODS
  Seventy-seven healthy volunteers (39 female and 38 male subjects; age range: 24-82 years old) were enrolled in the experiment including ESWAN and proton MRS sequences, consent for which was provided by themselves or their guardians. For each subject, the mean phase value gained by ESWAN was used to evaluate the iron deposition; choline/creatine (Cho/Cr) and mI/Cr ratios gained by (1)H-MRS were used to evaluate gliocyte metabolism in the basal ganglia region of both sides. The paired t test was used to test the difference between the two sides of the basal ganglia region. Linear regression was performed to evaluate the relation between mean phase value and age. Pearson's correlation coefficient was calculated to analyze the relationship between the result of ESWAN and (1)H-MRS.
  
  
  RESULTS
  There was no difference between the two sides of the basal ganglia region in the mean phase value and Cho/Cr. But in mI/Cr the mean phase value of each nucleus in bilateral basal ganglia decreased with increasing age. There are 16 r-values between the mean phase value and Cho/Cr and mI/Cr in bilateral basal ganglia region. And each of all p-values is less than 0.001 (p < 0.001).
  
  
  CONCLUSIONS
  Iron deposition in the bilateral basal ganglia is associated with the change of gliocyte metabolism with increasing age. Iron deposition in each nucleus of the basal ganglia region changes with age.
authors.affiliation: Department of Radiology, Shengjing Hospital of China Medical University, Heping District, Shenyang, China.
authors.forename: Haodi
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Radiology, Shengjing Hospital of China Medical University, Heping District, Shenyang, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wang
keywords: 3D-enhanced susceptibility weighted angiography (ESWAN); basal ganglia region; gliocyte metabolism; iron deposition; proton MRS (1H-MRS)