title: Enabling direct fate conversion with network biology.
abstract: Current efforts in cellular disease modeling and regenerative medicine are limited by the paucity of cell types that can be generated in the laboratory. A new study introduces a computational framework, Mogrify, that uses network biology to predict combinations of transcription factors necessary for direct conversion between human cell types to ameliorate this issue.
authors.affiliation: Institute for Cell Engineering and in the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: Cahan
mesh_terms: D002454:Cell Differentiation / Q000235:genetics*; D054338:Cell Transdifferentiation / Q000235:genetics*; D065150:Cellular Reprogramming / Q000235:genetics*; D053263:Gene Regulatory Networks; D006801:Humans