title: Efficacy of Azacitidine in autoimmune and inflammatory disorders associated with myelodysplastic syndromes and chronic myelomonocytic leukemia.
abstract: This retrospective study describes efficacy of Azacitidine on autoimmune disorders (AID) associated with MDS/CMML in 22 patients. Response of AID to Azacitidine was observed in 19 patients (86%). Reduction or discontinuation of steroids and/or immunosuppressive therapy (IST) was possible in 16 cases (73%). Hematologic response was seen in 55% of the patients. MDS/CMML and AID evolution was concordant in 13 cases (59%): both favorable (n=11), both unfavorable (n=2), but AID improved while MDS/CMML worsened (n=8) and vice versa (n=1). Azacitidine frequently seems effective in controlling steroid-dependent AID associated with MDS/CMML, but prospective studies are necessary to confirm those findings.
authors.affiliation: Service de Médecine Interne, Hôpital Jean Verdier, Assistance Publique des Hôpitaux de Paris, Université Paris XIII, France. Electronic address: jeanbaptiste.fraison@aphp.fr.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Fraison
authors.affiliation: Service de Médecine Interne, DHU i2B, Inflammation-Immunopathologie-Biothérapie (DHU i2B), Hôpital Saint Antoine, Assistance Publique des Hôpitaux de Paris, Université Paris VI Sorbonne, 75012 Paris, France.
authors.forename: Arsène
authors.initials: A
authors.lastname: Mekinian
authors.affiliation: Service d'hématologie, Institut de Cancérologie Gustave Roussy, 94800 Villejuif, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Grignano
authors.affiliation: Service de Médecine Interne, Hôpital Foch, Suresnes, France.
authors.forename: Jean-Emmanuel
authors.initials: JE
authors.lastname: Kahn
authors.affiliation: Service de Médecine Interne, Hôpital Européen Georges Pompidoux, Université Paris V, Paris, France.
authors.forename: Jean-Benoit
authors.initials: JB
authors.lastname: Arlet
authors.affiliation: Service de Médecine Interne, Centre Hospitalier Universitaire de Rennes, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Decaux
authors.affiliation: Service de Médecine Interne, Centre Hospitalier de Rochefort, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Denis
authors.affiliation: Service de Médecine Interne, Centre Hospitalier de Douai, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Buchdahl
authors.affiliation: Service de Rhumatologie, Centre Hospitalier de Romilly, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Omouri
authors.affiliation: Service de Médecine Interne, Centre Hospitalier Universitaire de Caen, France.
authors.forename: Gwenola
authors.initials: G
authors.lastname: Maigne
authors.affiliation: Service de Médecine Interne, Centre Hospitalier Universitaire de Caen, France.
authors.forename: Achille
authors.initials: A
authors.lastname: Aouba
authors.affiliation: Service de Rhumatologie, Centre Hospitalier Universitaire de Caen, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Leon
authors.affiliation: Service de Médecine Interne, Centre Hospitalier Universitaire de Dijon, France.
authors.forename: Sabine
authors.initials: S
authors.lastname: Berthier
authors.affiliation: Service de Médecine Interne, Centre Hospitalier Universitaire de Limoges, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Liozon
authors.affiliation: Service d'Hématologie, Centre Hospitalier Universitaire de Grenoble, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Park
authors.affiliation: Service d'Hématologie, Hôpital Avicenne, Université Paris XIII, Bobigny, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Gardin
authors.affiliation: Service de Maladies Infectieuses, Hôpital Necker, Université Paris V, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
authors.affiliation: Service d'hématologie, Institut de Cancérologie Gustave Roussy, 94800 Villejuif, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Rossignol
authors.affiliation: Service d'Hématologie, Hôpital Saint Louis, Université Paris VII, Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Fenaux
authors.affiliation: Service de Médecine Interne, DHU i2B, Inflammation-Immunopathologie-Biothérapie (DHU i2B), Hôpital Saint Antoine, Assistance Publique des Hôpitaux de Paris, Université Paris VI Sorbonne, 75012 Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Fain
authors.affiliation: Service d'Hématologie, Hôpital Avicenne, Université Paris XIII, Bobigny, France.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Braun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000188:drug therapy*; D001374:Azacitidine / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D001374:Azacitidine
keywords: Auto immune disorders; Azacitidine; Myelodysplastic syndromes