title: Synthesis of Nitro-Containing Compounds through Multistep Continuous Flow with Heterogeneous Catalysts.
abstract: Synthesis of β-nitrostyrene derivatives and their following reactions through two-step continuous-flow protocols with heterogeneous catalysts are described. In the first step to provide β-nitrostyrenes from aromatic aldehydes and nitromethane, readily available amino-functionalized silica gel was employed as a catalyst and gave the products continuously for at least 100 h with high selectivity. In the second step, reactions of β-nitrostyrenes, solid bases, immobilized bases, solid acids, and chiral supported metals and nonmetals were used as catalysts, and seven kinds of nitro-containing organic compounds could be effectively synthesized through the two-step continuous-flow systems.
authors.affiliation: Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo , Hongo Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Haruro
authors.initials: H
authors.lastname: Ishitani
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo , Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Saito
authors.affiliation: Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo , Hongo Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Tsubogo
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo , Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.|Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo , Hongo Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Shū
authors.initials: S
authors.lastname: Kobayashi