title: Pd(II)/CuBr2 catalysed keto α-C(sp3)-H benzoxylation of N,N-dialkylamides directed by o-hydroxy groups.
abstract: A hydroxy group directed keto α-C(sp3)-H benzoxylation of amides, including N,N-dialkylamides and cyclic amides, has been accomplished involving ortho-hydroxy substrates possessing either an aldehydic or a keto methyl (-COCH3) group with a Pd(II)/CuBr2 catalytic combination. The carboxy group obtained via the in situ oxidation of -CHO or -COCH3 groups of ortho-hydroxy substrates then undergoes a cross-dehydrogenative coupling (CDC) with amides to furnish an α-benzoxylation product with concurrent aromatic ring bromination.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, 781 039, Assam, India. patel@iitg.ernet.in.
authors.forename: Sourav Kumar
authors.initials: SK
authors.lastname: Santra
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, 781 039, Assam, India. patel@iitg.ernet.in.
authors.forename: Arghya
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, 781 039, Assam, India. patel@iitg.ernet.in.
authors.forename: Suresh
authors.initials: S
authors.lastname: Rajamanickam
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, 781 039, Assam, India. patel@iitg.ernet.in.
authors.forename: Nilufa
authors.initials: N
authors.lastname: Khatun
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, 781 039, Assam, India. patel@iitg.ernet.in.
authors.forename: Bhisma K
authors.initials: BK
authors.lastname: Patel