title: Swimming does not alter nociception threshold in obese rats submitted to median nerve compression.
abstract: OBJECTIVE
  We, herein, analyzed the effect of swimming on nociception threshold and peripheral nerve regeneration in lean and obese rats submitted to median nerve compression.
  
  
  METHODS
  To induce obesity, newborn male Wistar rats received injections of monosodium glutamate (MSG), whereas the control (CTL) group received saline. The animals were separated into 6 groups; control and obese (CTL and MSG), control and obese with lesion (CTL LES and MSG LES), and control and obese with lesion submitted to physical exercise (CTL LES PE and MSG LES PE).
  
  
  RESULTS
  Median nerve compression reduced nociception threshold in CTL LES and MSG LES rats. Swimming effectively altered nociception only in CTL LES PE animals. Lean and obese animals displayed histological differences, when compared to sedentary animals, and exercise improved axon regeneration in both groups. The brain-derived neurotrophic factor and GAP 43 protein expression was greater in animals submitted to nervous compression without alteration by exercise.
  
  
  CONCLUSIONS
  In conclusion, swimming, a conservative treatment for peripheral nerve lesions, was not able to improve the nociception threshold in obese rats.
authors.affiliation: 1 Laboratório do Estudo das Lesões e Recursos Fisioterapêuticos, Universidade Estadual do Oeste do Paraná , Cascavel, Brazil.
authors.forename: Josinéia Gresele
authors.initials: JG
authors.lastname: Coradini
authors.forename: Regina Inês
authors.initials: RI
authors.lastname: Kunz
authors.forename: Camila Mayumi Martin
authors.initials: CM
authors.lastname: Kakihata
authors.forename: Tatiane Kamada
authors.initials: TK
authors.lastname: Errero
authors.forename: Maria Lúcia
authors.initials: ML
authors.lastname: Bonfleur
authors.forename: Lucinéia de Fátima Chasko
authors.initials: Lde F
authors.lastname: Ribeiro
authors.forename: Rose Meire Costa
authors.initials: RM
authors.lastname: Brancalhão
authors.forename: Gladson Ricardo Flor
authors.initials: GR
authors.lastname: Bertolini
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D015992:Body Mass Index; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D004195:Disease Models, Animal; D019922:GAP-43 Protein / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D008297:Male; D008475:Median Nerve / Q000503:physiopathology; D009408:Nerve Compression Syndromes / Q000473:pathology / Q000503:physiopathology* / Q000534:rehabilitation*; D059225:Nociception / Q000502:physiology*; D009765:Obesity / Q000139:chemically induced / Q000150:complications*; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D012970:Sodium Glutamate / Q000494:pharmacology; D013550:Swimming
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D019922:GAP-43 Protein; D012970:Sodium Glutamate
keywords: Nerve regeneration; Obesity; Pain measurement; Swimming