title: Cytomorphology of ovarian clear cell carcinomas in peritoneal effusions.
abstract: OBJECTIVE
  To investigate and describe the cytomorphology of malignant effusions from ovarian clear cell carcinomas (OCCC).
  
  
  METHODS
  Five cases of malignant peritoneal effusions from OCCC histologically confirmed were analysed and compared.
  
  
  RESULTS
  Among the malignant peritoneal effusions exhibiting clear cell features, a characteristic feature of OCCC was the presence of large deposits of a hyaline matrix. This matrix may be typically arranged either in 'raspberry bodies' or 'globule-like' structures. Other rare neoplasms composed of clear cells must be considered in the differential diagnosis such as yolk sac tumour of the ovary, clear cell subtype of endometrial carcinoma and, less frequently, malignant peritoneal mesothelioma as well as metastatic renal cell carcinoma.
  
  
  CONCLUSIONS
  Ovarian clear cell carcinomas have distinct morphological features that are helpful in making a cytological diagnosis of this entity. The role of cytological examination in ovarian neoplasms is of paramount importance, as stated by The International Federation of Gynecology and Obstetrics (FIGO) recommendations.
authors.affiliation: Department of Biopathology, Gustave Roussy Comprehensive Cancer Center, Villejuif Cedex, France.
authors.forename: D
authors.initials: D
authors.lastname: Damiani
authors.affiliation: Department of Biopathology, Gustave Roussy Comprehensive Cancer Center, Villejuif Cedex, France.
authors.forename: V
authors.initials: V
authors.lastname: Suciu
authors.affiliation: Department of Biopathology, Gustave Roussy Comprehensive Cancer Center, Villejuif Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Genestie
authors.affiliation: Department of Biopathology, Gustave Roussy Comprehensive Cancer Center, Villejuif Cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Vielh
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis* / Q000473:pathology; D001202:Ascitic Fluid / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000473:pathology; D003581:Cytodiagnosis; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology; D008654:Mesothelioma / Q000175:diagnosis / Q000473:pathology; D000086002:Mesothelioma, Malignant; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016066:Pleural Effusion, Malignant / Q000175:diagnosis / Q000473:pathology
keywords: clear cell carcinoma; cytology; ovary; peritoneal effusion