title: Sophora flavescens (Ku-Shen) as a booster for antiretroviral therapy through cytochrome P450 3A4 inhibition.
authors.affiliation: School of Chinese Medicine, School of Biomedical Science, The Chinese University of Hong Kong.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Lin
authors.affiliation: School of Chinese Medicine, School of Biomedical Science, The Chinese University of Hong Kong & Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, USA.
authors.forename: C T
authors.initials: CT
authors.lastname: Che
authors.affiliation: Department of Microbiology & Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong.
authors.forename: S S
authors.initials: SS
authors.lastname: Lee
authors.affiliation: Department of Microbiology, The Chinese University of Hong Kong.
authors.forename: R C Y
authors.initials: RC
authors.lastname: Chan
authors.affiliation: School of Chinese Medicine, School of Biomedical Science, The Chinese University of Hong Kong.
authors.forename: P S P
authors.initials: PS
authors.lastname: Ip
authors.affiliation: School of Chinese Medicine, School of Biomedical Science, The Chinese University of Hong Kong.
authors.forename: J M
authors.initials: JM
authors.lastname: Yang
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000818:Animals; D018938:Caco-2 Cells; D051544:Cytochrome P-450 CYP3A / Q000187:drug effects* / Q000378:metabolism; D065692:Cytochrome P-450 CYP3A Inhibitors / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D041743:Herb-Drug Interactions; D006801:Humans; D019469:Indinavir / Q000493:pharmacokinetics; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D019438:Ritonavir / Q000494:pharmacology; D029909:Sophora / Q000737:chemistry*; D015854:Up-Regulation
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D065692:Cytochrome P-450 CYP3A Inhibitors; D010936:Plant Extracts; D019469:Indinavir; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D019438:Ritonavir