title: The Impact of Obstructive Sleep Apnoea and Nasal Continuous Positive Airway Pressure on Circulating Ischaemia-Modified Albumin Concentrations.
abstract: The aim of the present study was to evaluate the impact of obstructive sleep apnoea syndrome (OSAS) and the effects of nasal continuous positive airway pressure (CPAP) on circulating ischaemia-modified albumin (IMA) concentrations. The study included 97 newly diagnosed OSAS patients and 30 nonapnoeic controls. Blood samples were obtained in the morning after polysomnography. After 3 months of CPAP treatment, 31 patients with moderate-severe OSAS were reassessed for serum IMA concentrations. Significantly higher serum IMA concentrations were measured in the OSAS group than in the control group [0.518 ± 0.091 absorbance units (ABSU), 0.415 ± 0.068 ABSU, P < 0.001]. Serum IMA concentrations correlated significantly with the apnoea-hypopnoea index, mean SaO2, desaturation index, and C-reactive protein concentrations. Multiple logistic regression analyses showed that OSAS increased the serum IMA concentration independent of age, sex, body mass index, smoking habit, and cardiovascular disease. After 3 months of treatment with CPAP, OSAS patients had significantly lower serum IMA concentrations (0.555 ± 0.062 ABSU to 0.431 ± 0.063 ABSU, P < 0.001). The results showed that OSAS is associated with elevated concentrations of IMA, which can be reversed by effective CPAP treatment.
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Firat
authors.initials: F
authors.lastname: Uygur
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Tanriverdi
authors.affiliation: Faculty of Medicine, Department of Biochemistry Zonguldak, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Can
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Tacettin
authors.initials: T
authors.lastname: Ornek
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Erboy
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Altinsoy
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Atalay
authors.affiliation: Faculty of Medicine, Department of Otolaryngology, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Damar
authors.affiliation: Faculty of Medicine, Department of Biostatistics, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Furuzan
authors.initials: F
authors.lastname: Kokturk
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Tor
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy*
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human