title: Stereotactic Body Radiotherapy Provides Excellent Long-Term Local Control of Very Few Lung Metastases.
abstract: OBJECTIVE
  To evaluate treatment outcomes after stereotactic body radiotherapy (SBRT) for a limited number of lung metastases mainly focusing on local control.
  
  
  METHODS
  Forty-six patients receiving SBRT for 1-3 lung metastases were retrospectively evaluated. Local control, freedom from distant progression and overall survival were evaluated in the entire series. In addition, nine factors (gender, age, performance status, interval between cancer diagnosis and SBRT, primary tumor type, other metastases, main site and number of lesions, irradiated volume, SBRT dose) were evaluated for local control.
  
  
  RESULTS
  Local control rates at 1, 2 and 3 years were 93%, 93% and 78%, respectively. Rates of freedom from distant progression were 57%, 38% and 29%, respectively, and overall survival rates were 66%, 56% and 36%, respectively. Only one patient (2%) experienced radiation-induced pneumonitis.
  
  
  CONCLUSIONS
  SBRT administered for very few lung metastases resulted in excellent long-term local control rates and was associated with very little toxicity.
authors.affiliation: Department of Radiation Oncology, University of Lübeck, Lübeck, Germany Medical Practice for Radiotherapy and Radiation Oncology, Hannover, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Janssen
authors.affiliation: Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
authors.forename: Lukas
authors.initials: L
authors.lastname: Käsmann
authors.affiliation: Department of Radiation Oncology, Saad Specialist Hospital, Al Khobar, Kingdom of Saudi Arabia.
authors.forename: Volker
authors.initials: V
authors.lastname: Rudat
authors.affiliation: Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net.
authors.forename: Dirk
authors.initials: D
authors.lastname: Rades
mesh_terms: D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D017564:Radiation Pneumonitis / Q000209:etiology; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome; D047368:Tumor Burden
keywords: Lung metastases; local control; long-term results; pneumonitis; stereotactic body radiotherapy