title: Aortic Neck Anatomic Features and Predictors of Outcomes in Endovascular Repair of Abdominal Aortic Aneurysms Following vs Not Following Instructions for Use.
abstract: BACKGROUND
  A significant number of patients undergo endovascular repair of abdominal aortic aneurysms (EVAR) outside the instructions for use (IFU). This study will examine various aortic neck features and their predictors of clinical outcomes.
  
  
  METHODS
  We performed a retrospective analysis of prospectively collected data on EVAR patients. Neck features outside IFU were analyzed. Kaplan-Meier and multivariate analyses were used to predict their effect as single features, or in combination, on outcomes.
  
  
  RESULTS
  Fifty-two percent of 526 patients had 1 or more features outside the IFU. The overall technical success rate was 99%, and perioperative complication rates were 7% and 12% for IFU vs outside IFU use, respectively (p = 0.04). Type I early endoleak and early intervention rates were 7% and 10% for IFU vs 18% and 24% for outside IFU (p = 0.0002 and p < 0.0001). At a mean follow-up of 30 months, freedom from late type I endoleak and late reintervention at 1, 2, and 3 years for IFU were 99.5%, 99.5%, and 98.4%, and 99.4%, 98%, and 96.8%; vs 98.9%, 98.1%, and 98.1%, and 97.5%, 96.2%, and 95.2% for outside IFU (p = 0.049 and 0.799), respectively. Survival rates at 1, 2, and 3 years for IFU were 97%, 93.5%, and 89.8%; vs 93.7%, 88.8%, and 86.3% for outside IFU (p = 0.035). Multivariate analysis showed that a neck angle > 60 degrees had odds ratios for death, sac expansion, and early intervention of 6, 2.6, and 3.3, respectively; neck length < 10 mm had odds ratios of 2.8 for deaths, 3.4 for early intervention, 4.6 for late reintervention, and 4.3 for late type I endoleak.
  
  
  CONCLUSIONS
  Patients with neck features outside IFU can be treated with EVAR; however, they have higher rates of early and late type I endoleak, early intervention, and late death.
authors.affiliation: Department of Surgery, West Virginia University, Charleston, WV. Electronic address: ali.aburahma@camc.org.
authors.forename: Ali F
authors.initials: AF
authors.lastname: AbuRahma
authors.affiliation: Department of Surgery, West Virginia University, Charleston, WV.
authors.forename: Michael
authors.initials: M
authors.lastname: Yacoub
authors.affiliation: Department of Surgery, West Virginia University, Charleston, WV.
authors.forename: Albeir Y
authors.initials: AY
authors.lastname: Mousa
authors.affiliation: Department of Surgery, West Virginia University, Charleston, WV.
authors.forename: Shadi
authors.initials: S
authors.lastname: Abu-Halimah
authors.affiliation: Department of Surgery, West Virginia University, Charleston, WV.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Hass
authors.affiliation: Department of Surgery, West Virginia University, Charleston, WV.
authors.forename: Jenna
authors.initials: J
authors.lastname: Kazil
authors.affiliation: Department of Surgery, West Virginia University, Charleston, WV.
authors.forename: Zachary T
authors.initials: ZT
authors.lastname: AbuRahma
authors.affiliation: Department of Surgery, West Virginia University, Charleston, WV.
authors.forename: Mohit
authors.initials: M
authors.lastname: Srivastava
authors.affiliation: CAMC Health Education and Research Institute, Charleston, WV.
authors.forename: L Scott
authors.initials: LS
authors.lastname: Dean
authors.affiliation: Department of Surgery, West Virginia University, Charleston, WV.
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Stone
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation; D057867:Endoleak / Q000453:epidemiology / Q000473:pathology; D057510:Endovascular Procedures; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D016017:Odds Ratio; D018579:Patient Selection; D012189:Retrospective Studies; D016896:Treatment Outcome