title: Haploidentical Donors: Can Faster Transplantation Be Life-Saving for Patients with Advanced Disease?
abstract: Haploidentical stem cell transplantation is a therapeutic option for patients without an HLA-matched donor. It is increasingly being used worldwide due to the application of posttransplantation cyclophosphamide and is associated with lower incidence of graft-versus-host disease and treatment-related mortality. Haploidentical donors are generally available for most patients and stem cells can be rapidly obtained. Delays in transplantation while waiting for unrelated donor cells can be potentially problematic for patients with advanced disease at risk for progression; thus, the use of haploidentical donors, especially in this setting, can be life-saving. Here we reviewed the literature on haploidentical stem cell transplantation performed with posttransplantation cyclophosphamide.
authors.affiliation: Department of Stem Cell Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Alina
authors.initials: A
authors.lastname: Tanase
authors.forename: Ciprian
authors.initials: C
authors.lastname: Tomuleasa
authors.forename: Alexandra
authors.initials: A
authors.lastname: Marculescu
authors.forename: Alexandru
authors.initials: A
authors.lastname: Bardas
authors.forename: Anca
authors.initials: A
authors.lastname: Colita
authors.forename: Carmen
authors.initials: C
authors.lastname: Orban
authors.forename: Stefan Octavian
authors.initials: SO
authors.lastname: Ciurea
mesh_terms: D003520:Cyclophosphamide / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000188:drug therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D015994:Incidence; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D061349:Unrelated Donors
chemical_list: D003520:Cyclophosphamide