title: Palladium-catalyzed regioselective C-2 arylation of 7-azaindoles, indoles, and pyrroles with arenes.
abstract: A palladium-catalyzed regioselective C-2 arylation of 7-azaindoles, indoles, and pyrroles with arenes has been developed. This study unveils that a critical substrate dependent acid concentration is essential for achieving exclusive C-2 selectivity as well as mono-arylation in pyrroles. Incongruent to the literature, the protocol uses a reduced volume (at least 5 times) of arenes for workable access to C-2 arylated heterocycles.
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education and Research, S. A. S. Nagar, Punjab 160062, India. jlaha@niper.ac.in.
authors.forename: Joydev K
authors.initials: JK
authors.lastname: Laha
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education and Research, S. A. S. Nagar, Punjab 160062, India. jlaha@niper.ac.in.
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Bhimpuria
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education and Research, S. A. S. Nagar, Punjab 160062, India. jlaha@niper.ac.in.
authors.forename: Dilip V
authors.initials: DV
authors.lastname: Prajapati
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education and Research, S. A. S. Nagar, Punjab 160062, India. jlaha@niper.ac.in.
authors.forename: Neetu
authors.initials: N
authors.lastname: Dayal
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education and Research, S. A. S. Nagar, Punjab 160062, India. jlaha@niper.ac.in.
authors.forename: Shubhra
authors.initials: S
authors.lastname: Sharma
mesh_terms: D002384:Catalysis; D006844:Hydrocarbons, Cyclic / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
chemical_list: D006844:Hydrocarbons, Cyclic; D007211:Indoles; D011758:Pyrroles; D010165:Palladium