title: Norovirus Infections Occur in B-Cell-Deficient Patients.
abstract: Norovirus incidence was compared between severe combined immunodeficiency children with (n = 10) and without (n = 8) B cells. 60% of B+ and 63% of B- patients developed norovirus infections therefore norovirus replication in B lymphocytes is not essential for infection.
authors.affiliation: Microbiology Virology & Infection Control, Great Ormond Street Hospital for Children National Health Service (NHS) Foundation Trust.|National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London.
authors.forename: Julianne R
authors.initials: JR
authors.lastname: Brown
authors.affiliation: Immunology Department, Great Ormond Street Hospital for Children NHS Foundation Trust.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Gilmour
authors.affiliation: Microbiology Virology & Infection Control, Great Ormond Street Hospital for Children National Health Service (NHS) Foundation Trust.|Infection and Immunity, University College London, United Kingdom.
authors.forename: Judith
authors.initials: J
authors.lastname: Breuer
mesh_terms: D000293:Adolescent; D001402:B-Lymphocytes / Q000473:pathology / Q000821:virology*; D017250:Caliciviridae Infections / Q000276:immunology / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D029322:Norovirus / Q000276:immunology*; D012189:Retrospective Studies; D016511:Severe Combined Immunodeficiency / Q000821:virology*
keywords: B cells; SCID; in vivo; norovirus