title: Perenosins: a new class of anion transporter with anti-cancer activity.
abstract: A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl(-)/NO3(-) antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.
authors.affiliation: Department of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK. philip.gale@soton.ac.uk.
authors.forename: Wim
authors.initials: W
authors.lastname: Van Rossom
authors.affiliation: Department of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK. philip.gale@soton.ac.uk.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Asby
authors.affiliation: Department of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK. philip.gale@soton.ac.uk.
authors.forename: Ali
authors.initials: A
authors.lastname: Tavassoli
authors.affiliation: Department of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK. philip.gale@soton.ac.uk.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Gale
mesh_terms: D000838:Anions / Q000378:metabolism*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017920:Antiporters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007097:Imines / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D017136:Ion Transport / Q000187:drug effects; D061986:MCF-7 Cells; D008958:Models, Molecular; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000838:Anions; D000972:Antineoplastic Agents, Phytogenic; D017920:Antiporters; D007097:Imines; D007211:Indoles; D011758:Pyrroles