title: Novel insights in drug metabolism by MS imaging.
abstract: During the last decade, lateral and temporal localization of drug compounds and their metabolites have been demonstrated and dynamically developed using MS imaging. The pharmaceutical industry has recognized the potential of the technology that provides simultaneous distribution and quantitative data. In this review, we present the latest technological achievements and summarize applications of drug imaging focusing on studies about metabolites by MALDI-MS imaging. We also introduce potential areas with pharmaceutical applications that are currently under exploration, including pharmacological, toxicological characterizations and metabolic enzyme localization in comparison with drug and metabolite distribution.
authors.affiliation: Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden.|Department of Biomedical Engineering, Clinical Protein Science & Imaging, BMC D13, Lund University, Lund, Sweden.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugihara
authors.affiliation: Department of Biomedical Engineering, Clinical Protein Science & Imaging, BMC D13, Lund University, Lund, Sweden.|Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co. Ltd, 33-94 Enoki-cho, Suita, Osaka, 564-0053, Japan.
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Biomedical Engineering, Clinical Protein Science & Imaging, BMC D13, Lund University, Lund, Sweden.|Department of Pharmacology & Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1048, USA.
authors.forename: Ákos
authors.initials: Á
authors.lastname: Végvári
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000378:metabolism*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D057170:Translational Research, Biomedical; D051598:Whole Body Imaging
chemical_list: D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System
keywords: MS imaging; drug localization; drug metabolism; metabolic enzymes