title: Polymeric nanobiocomposites for biomedical applications.
abstract: Polymeric nanobiocomposites have recently become one of the most essential sought after materials for biomedical applications ranging from implants to the creation of gels. Their unique mechanical and biological properties provide them the ability to pass through the highly guarded defense mechanism without undergoing noticeable degradation and initiation of immune responses, which in turn makes them advantageous over the other alternatives. Aligned with the advances in tissue engineering, it is also possible to design three-dimensional extracellular matrix using these polymeric nanobiocomposites that could closely mimic the human tissues. In fact, unique polymer chemistry coupled with nanoparticles could create unique microenvironment that promotes cell growth and differentiation. In addition, the nanobiocomposites can also be devised to carry drugs efficiently to the target site without exhibiting any cytotoxicity as well as to eradicate surgical infections. In this article, an effort has been made to thoroughly review a number of different types/classes of polymeric nanocomposites currently used in biomedical fields. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1241-1259, 2017.
authors.affiliation: Chemical & Petroleum Engineering Department, UAE University, Al Ain, UAE.
authors.forename: Mohammad Sayem
authors.initials: MS
authors.lastname: Mozumder
authors.affiliation: Chemical & Petroleum Engineering Department, UAE University, Al Ain, UAE.
authors.forename: Anusha
authors.initials: A
authors.lastname: Mairpady
authors.affiliation: Mechanical Engineering Department, UAE University, Al Ain, P.O. Box 15551, UAE.
authors.forename: Abdel-Hamid I
authors.initials: AI
authors.lastname: Mourad
mesh_terms: D000818:Animals; D063566:Biodegradable Plastics / Q000737:chemistry / Q000627:therapeutic use; D060833:Cellular Microenvironment; D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use; D005109:Extracellular Matrix / Q000737:chemistry*; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D063566:Biodegradable Plastics; D004337:Drug Carriers
keywords: biological properties; mechanical properties; nanobiocomposites; polymer; scaffolds; tissue engineering