title: A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats.
abstract: BACKGROUND
  It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activity in the frontal cortex (FC). It has been also proposed that the high-fat diet (HFD) could disturb the metabolism of glutamate and consequently the GABA levels, but the mechanism is not yet clearly understood. Therefore, the aim of this study was to investigate the effect of a HFD on the GABA levels in the FC and hippocampus of rats.
  
  
  RESULTS
  The HFD significantly increased weight gain and blood glucose levels, whereas decreased the GABA levels in the FC and hippocampus compared with standard diet-fed rats.
  
  
  CONCLUSIONS
  HFD decreases GABA levels in the FC and hippocampus of rat, which likely disrupts the GABAergic inhibitory processes, underlying feeding behavior.
authors.affiliation: Departamento de Enfermería y Obstetricia, Universidad de Guanajuato, Celaya, GTO, Mexico. cuauhtemocss@gmail.com.
authors.forename: Cuauhtemoc
authors.initials: C
authors.lastname: Sandoval-Salazar
authors.affiliation: Departamento de Ciencias Médicas, División de Ciencias de la Salud, Campus León, Universidad de Guanajuato, 20 de Enero 929, C.P. 37000, León, GTO, Mexico. joelre@ugto.mx.
authors.forename: Joel
authors.initials: J
authors.lastname: Ramírez-Emiliano
authors.affiliation: Departamento de Ciencias Médicas, División de Ciencias de la Salud, Campus León, Universidad de Guanajuato, 20 de Enero 929, C.P. 37000, León, GTO, Mexico. aurora.stb@gmail.com.
authors.forename: Aurora
authors.initials: A
authors.lastname: Trejo-Bahena
authors.affiliation: Departamento de Medicina y Nutrición, Universidad de Guanajuato, León, GTO, Mexico. cioviedo@outlook.com.
authors.forename: Cecilia I
authors.initials: CI
authors.lastname: Oviedo-Solís
authors.affiliation: Departamento de Ciencias Médicas, División de Ciencias de la Salud, Campus León, Universidad de Guanajuato, 20 de Enero 929, C.P. 37000, León, GTO, Mexico. silviasolis17@prodigy.net.mx.
authors.forename: Martha Silvia
authors.initials: MS
authors.lastname: Solís-Ortiz
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D059305:Diet, High-Fat; D005247:Feeding Behavior; D005625:Frontal Lobe / Q000737:chemistry* / Q000378:metabolism; D006624:Hippocampus / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000378:metabolism; D017208:Rats, Wistar; D012016:Reference Values; D015430:Weight Gain; D005680:gamma-Aminobutyric Acid / Q000032:analysis* / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D005680:gamma-Aminobutyric Acid