title: A mathematical model to simulate the cardiotocogram during labor. Part B: Parameter estimation and simulation of variable decelerations.
abstract: During labor and delivery the cardiotocogram (CTG), the combined registration of fetal heart rate (FHR) and uterine contractions, is used to monitor fetal well-being. In part A of our study we introduced a new mathematical computer model for CTG simulation in order to gain insight into the complex relation between these signals. By reducing model complexity and by using physically more realistic descriptions, this model was improved with respect to our previous model. Aim of part B of this study is to gain insight into the cascade of events from uterine contractions causing combined uterine flow reduction and umbilical cord compression, resulting in blood and oxygen pressure variations, which lead to changes in FHR via the baro- and chemoreflex. In addition, we extensively describe and discuss the estimation of model parameter values. Simulation results are in good agreement with sheep data and show the ability of the model to describe variable decelerations. Despite reduced model complexity, parameter estimation still remains difficult due to limited clinical data.
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands; Department of Gynecology and Obstetrics, Máxima Medical Center, Veldhoven, The Netherlands. Electronic address: g.j.l.m.jongen@tue.nl.
authors.forename: Germaine J L M
authors.initials: GJ
authors.lastname: Jongen
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands; Department of Gynecology and Obstetrics, Máxima Medical Center, Veldhoven, The Netherlands.
authors.forename: M Beatrijs
authors.initials: MB
authors.lastname: van der Hout-van der Jagt
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands.
authors.forename: Frans N
authors.initials: FN
authors.lastname: van de Vosse
authors.affiliation: Department of Gynecology and Obstetrics, Máxima Medical Center, Veldhoven, The Netherlands; Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
authors.forename: S Guid
authors.initials: SG
authors.lastname: Oei
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands.
authors.forename: Peter H M
authors.initials: PH
authors.lastname: Bovendeerd
mesh_terms: D000818:Animals; D015148:Cardiotocography; D003654:Deceleration; D005260:Female; D006340:Heart Rate, Fetal; D006801:Humans; D007743:Labor, Obstetric / Q000502:physiology*; D008955:Models, Cardiovascular; D011247:Pregnancy; D012756:Sheep; D014590:Uterine Contraction
keywords: Baroreflex; Chemoreflex; Computer simulation model; Fetal heart rate; Umbilical cord compression