title: Optimizing dissolution dynamic nuclear polarization.
abstract: This article is a short review of some of our recent developments in dissolution dynamic nuclear polarization (d-DNP). We present the basic principles of d-DNP, and motivate our choice to step away from conventional approaches. We then introduce a modified d-DNP recipe that can be summed up as follows. (i) Using broad line polarizing agents to efficiently polarize 1H spins. (ii) Increasing the magnetic field to 6.7 T and above. (iii) Applying microwave frequency modulation. (iv) Applying (1)H-(13)C cross polarization. (v) Transferring hyperpolarized solution through a magnetic tunnel.
authors.affiliation: Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Batochime, CH-1015 Lausanne, Switzerland. Electronic address: aurelien.bornet@epfl.ch.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Bornet
authors.affiliation: Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Batochime, CH-1015 Lausanne, Switzerland; Bruker BioSpin AG, Industriestrasse 26, 8117 Fällanden, Switzerland. Electronic address: sami.jannin@epfl.ch.
authors.forename: Sami
authors.initials: S
authors.lastname: Jannin
mesh_terms: D004574:Electromagnetic Fields; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D008872:Microwaves; D012995:Solubility
chemical_list: D007202:Indicators and Reagents
keywords: Cross polarization; Dissolution dynamic nuclear polarization; Hyperpolarization