title: Nanotechnology in diagnosis and treatment of coronary artery disease.
abstract: Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis. Nanotechnology can increase the efficiency of drugs, improve local and systematic delivery to atherosclerotic plaques and reduce the inflammatory or angiogenic response after intravascular intervention. Nanocarriers have potential for delivery of imaging and diagnostic agents to precisely targeted destinations. This review paper will cover the current applications and future outlook of nanotechnology, as well as the main diagnostic methods, in the treatment of CAD.
authors.affiliation: Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Karimi
authors.affiliation: Biomaterials Group, Materials Science & Engineering Department, Iran University of Science & Technology, P.O. Box 1684613114 Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Zare
authors.affiliation: Division of Biomedical Engineering, Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran 1439957131 Tehran, Iran.
authors.forename: Amirala
authors.initials: A
authors.lastname: Bakhshian Nik
authors.affiliation: Biomaterials Group, Materials Science & Engineering Department, Iran University of Science & Technology, P.O. Box 1684613114 Tehran, Iran.
authors.forename: Narges
authors.initials: N
authors.lastname: Yazdani
authors.affiliation: Biomaterials Group, Materials Science & Engineering Department, Iran University of Science & Technology, P.O. Box 1684613114 Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hamrang
authors.affiliation: Biomaterials Group, Materials Science & Engineering Department, Iran University of Science & Technology, P.O. Box 1684613114 Tehran, Iran.
authors.forename: Elmira
authors.initials: E
authors.lastname: Mohamed
authors.affiliation: Department of Materials Science & Engineering, Sharif University of Technology, P.O. Box 11365-9466, 14588 Tehran, Iran.
authors.forename: Parham
authors.initials: P
authors.lastname: Sahandi Zangabad
authors.affiliation: School of Computer Science, Institute for Research in Fundamental Sciences, Tehran, Iran.|Civil & Environmental Engineering Department, Shahid Beheshti University, Tehran, Iran.
authors.forename: Seyed Masoud
authors.initials: SM
authors.lastname: Moosavi Basri
authors.affiliation: Biomaterials Group, Materials Science & Engineering Department, Iran University of Science & Technology, P.O. Box 1684613114 Tehran, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Bakhtiari
authors.affiliation: Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.|Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA.|Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA 02139, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Hamblin
mesh_terms: D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D004337:Drug Carriers / Q000627:therapeutic use; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use*; D036103:Nanotechnology / Q000379:methods*; D058226:Plaque, Atherosclerotic / Q000188:drug therapy / Q000473:pathology
chemical_list: D004337:Drug Carriers
keywords: atherosclerosis; coronary artery disease; nanocarriers; nanotechnology; restenosis; stent coatings; vulnerable plaque