title: OntoCR: A CEN/ISO-13606 clinical repository based on ontologies.
abstract: OBJECTIVE
  To design a new semantically interoperable clinical repository, based on ontologies, conforming to CEN/ISO 13606 standard.
  
  
  METHODS
  The approach followed is to extend OntoCRF, a framework for the development of clinical repositories based on ontologies. The meta-model of OntoCRF has been extended by incorporating an OWL model integrating CEN/ISO 13606, ISO 21090 and SNOMED CT structure.
  
  
  RESULTS
  This approach has demonstrated a complete evaluation cycle involving the creation of the meta-model in OWL format, the creation of a simple test application, and the communication of standardized extracts to another organization.
  
  
  CONCLUSIONS
  Using a CEN/ISO 13606 based system, an indefinite number of archetypes can be merged (and reused) to build new applications. Our approach, based on the use of ontologies, maintains data storage independent of content specification. With this approach, relational technology can be used for storage, maintaining extensibility capabilities.
  
  
  CONCLUSIONS
  The present work demonstrates that it is possible to build a native CEN/ISO 13606 repository for the storage of clinical data. We have demonstrated semantic interoperability of clinical information using CEN/ISO 13606 extracts.
authors.affiliation: Medical Informatics, Hospital Clínic, Unit of Medical Informatics, University of Barcelona, Barcelona, Spain; Department of Computer Science, Autonomous University of Barcelona, Barcelona, Spain. Electronic address: rlozano@clinic.ub.es.
authors.forename: Raimundo
authors.initials: R
authors.lastname: Lozano-Rubí
authors.affiliation: Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Muñoz Carrero
authors.affiliation: Hospital Doce de Octubre, Madrid, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Serrano Balazote
authors.affiliation: Medical Informatics, Hospital Clínic, Unit of Medical Informatics, University of Barcelona, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Pastor
mesh_terms: D000465:Algorithms; D064229:Biological Ontologies; D057286:Electronic Health Records / Q000592:standards*; D005568:Forms and Records Control / Q000592:standards; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D011381:Programming Languages; D012660:Semantics; D012984:Software; D039061:Systematized Nomenclature of Medicine; D018511:Systems Integration
keywords: CEN/ISO 13606; Clinical repository; Electronic health record; Information modeling; Ontologies; Semantic interoperability