title: Discovery of hantavirus circulating among Rattus rattus in French Mayotte island, Indian Ocean.
abstract: Hantaviruses are emerging zoonotic viruses that cause human diseases. In this study, sera from 642 mammals from La Réunion and Mayotte islands (Indian Ocean) were screened for the presence of hantaviruses by molecular analysis. None of the mammals from La Réunion island was positive, but hantavirus genomic RNA was discovered in 29/160 (18 %) Rattus rattus from Mayotte island. The nucleoprotein coding region was sequenced from the liver and spleen of all positive individuals allowing epidemiological and intra-strain variability analyses. Phylogenetic analysis based on complete coding genomic sequences showed that this Murinae-associated hantavirus is a new variant of Thailand virus. Further studies are needed to investigate hantaviruses in rodent hosts and in Haemorrhagic Fever with Renal Syndrome (HFRS) human cases.
authors.affiliation: Institut Pasteur, Unité des Stratégies Antivirales, F-75015, Paris, France.
authors.forename: Claudia
authors.initials: C
authors.lastname: Filippone
authors.affiliation: INRA, UMR 1062 CBGP, F-34988 Montferrier-sur-Lez, France and Institut de Biologie Computationnelle, 34095 Montpellier, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Castel
authors.affiliation: Anses-Laboratoire de Lyon, Unité de Virologie, Lyon, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Murri
authors.affiliation: Centre de Recherche Clinique, Hôpital Croix Rousse, Lyon, France.
authors.forename: Frédérik
authors.initials: F
authors.lastname: Beaulieux
authors.affiliation: Institut Pasteur, Unité des Stratégies Antivirales, F-75015, Paris, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Ermonval
authors.affiliation: Institut Pasteur, Unité des Stratégies Antivirales, F-75015, Paris, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Jallet
authors.affiliation: Wildlife Zoonoses and Vector-borne Diseases Research Group, Animal and Plant Health Agency, Woodham Lane, New Haw, Surrey, KT15 3NB, UK.
authors.forename: Emma L
authors.initials: EL
authors.lastname: Wise
authors.affiliation: Wildlife Zoonoses and Vector-borne Diseases Research Group, Animal and Plant Health Agency, Woodham Lane, New Haw, Surrey, KT15 3NB, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Ellis
authors.affiliation: Wildlife Zoonoses and Vector-borne Diseases Research Group, Animal and Plant Health Agency, Woodham Lane, New Haw, Surrey, KT15 3NB, UK.
authors.forename: Denise A
authors.initials: DA
authors.lastname: Marston
authors.affiliation: Wildlife Zoonoses and Vector-borne Diseases Research Group, Animal and Plant Health Agency, Woodham Lane, New Haw, Surrey, KT15 3NB, UK.|Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK.
authors.forename: Lorraine M
authors.initials: LM
authors.lastname: McElhinney
authors.affiliation: Wildlife Zoonoses and Vector-borne Diseases Research Group, Animal and Plant Health Agency, Woodham Lane, New Haw, Surrey, KT15 3NB, UK.|Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK.
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Fooks
authors.affiliation: UR346 Animal Epidemiology, INRA, Saint Genès Champanelle, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Desvars
authors.affiliation: Mérial, Lyon, France.
authors.forename: Lénaı G
authors.initials: LG
authors.lastname: Halos
authors.affiliation: UR346 Animal Epidemiology, INRA, Saint Genès Champanelle, France.
authors.forename: Gwenaël
authors.initials: G
authors.lastname: Vourc'h
authors.affiliation: Anses-Laboratoire de Lyon, Unité de Virologie, Lyon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Marianneau
authors.affiliation: Institut Pasteur, Unité des Stratégies Antivirales, F-75015, Paris, France.
authors.forename: Noël
authors.initials: N
authors.lastname: Tordo
mesh_terms: D000818:Animals; D017507:Comoros / Q000453:epidemiology; D005260:Female; D014644:Genetic Variation; D006476:Orthohantavirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D018778:Hantavirus Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D008297:Male; D010802:Phylogeny; D051381:Rats; D012376:Rodent Diseases / Q000453:epidemiology / Q000821:virology*