title: Neuropsychological results after gamma knife radiosurgery for mesial temporal lobe epilepsy.
abstract: OBJECTIVE
  The aim of this study is to summarize our experience with neuropsychological changes after radiosurgical treatment for mesial temporal lobe epilepsy and subsequent surgery due to insufficient seizure control.
  
  
  METHODS
  Between November 1995 and May 1999, 14 patients underwent radiosurgical entorhinoamygdalohippocampectomy with a marginal dose of 18, 20 or 25 Gy to the 50% isodose. 9 of these patients subsequently underwent surgery. We compared Memory Quotients and Intelligence Quotients before and after the interventions.
  
  
  RESULTS
  We found a slight, but nonsignificant decline in intelligence and memory quotients one year after GKRS. Two years after radiosurgery there were no significant changes in any of the quotients. After surgery, we found significant increase in Global and Visual MQ, (p<0.05). There were no statistically significant changes in verbal memory and intelligence performance after surgery.
  
  
  CONCLUSIONS
  Epilepsy surgery after unsuccessful radiosurgery could lead to improvements in cognitive functions in patients with mesial temporal lobe epilepsy.
authors.affiliation: Department of Neurology, Center for Epilepsy, Na Homolce Hospital, Prague, Czech Republic.
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Vojtěch
authors.affiliation: Department of Clinical Psychology, Center for Epilepsy, Na Homolce Hospital, Prague, Czech Republic.
authors.forename: Lenka
authors.initials: L
authors.lastname: Krámská
authors.affiliation: Department of Radiology, Center for Epilepsy, Na Homolce Hospital, Prague, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Malíková
authors.affiliation: Department of Neurology, Center for Epilepsy, Na Homolce Hospital, Prague, Czech Republic.
authors.forename: Michaela
authors.initials: M
authors.lastname: Stará
authors.affiliation: Department of Stereotactic and Radiation Neurosurgery, Center for Epilepsy, Na Homolce Hospital, Prague, Czech Republic.
authors.forename: Roman
authors.initials: R
authors.lastname: Liščák
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004833:Epilepsy, Temporal Lobe / Q000523:psychology / Q000601:surgery*; D005260:Female; D006801:Humans; D007360:Intelligence; D007361:Intelligence Tests; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D016634:Radiosurgery; D012189:Retrospective Studies; D016896:Treatment Outcome