title: Persistence of metabolic monitoring for psychiatry inpatients treated with second-generation antipsychotics utilizing a computer-based intervention.
abstract: OBJECTIVE
  Monitoring and intervention for metabolic abnormalities secondary to second-generation antipsychotics (SGAs) remain weak areas of performance in mental health care. This study evaluated the sustained impact of a computerized physician order entry (CPOE) pop-up alert designed to improve rates of laboratory metabolic monitoring of patients treated with SGAs in an inpatient psychiatry unit. Interventions carried out by the psychiatry team to manage metabolic abnormalities found on screening were also identified.
  
  
  METHODS
  A retrospective chart review of patients treated with scheduled SGAs at a large Midwestern academic medical centre's inpatient adult psychiatry unit was conducted nearly 4 years after the initial implementation of a pop-up alert. Rates of laboratory monitoring (blood glucose level, haemoglobin A1C [HbA1c], lipid panel) were compared to those following the initial implementation. Medical charts of patients with abnormal laboratory results were also reviewed to summarize interventions made by the psychiatry team to manage identified abnormalities.
  
  
  CONCLUSIONS
  Patient demographics in the current study population (n = 129) were similar to those in the initial test cohort (n = 157). There was no significant decrease in monitoring of glucose levels and lipid panels (fasting or random). Nine patients with abnormally elevated laboratories were identified. Interventions by the psychiatry team included referrals to appropriate healthcare professionals and initiation of medication.
  
  
  CONCLUSIONS
  The rate of metabolic monitoring for inpatients on SGA therapy did not significantly change over time with the continued use of the CPOE pop-up alert. Optimal monitoring utilizing a CPOE pop-up alert may allow the psychiatry team, including psychiatric pharmacists, to better manage metabolic conditions.
authors.affiliation: University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.affiliation: University of Michigan Department of Psychiatry, Ann Arbor, MI, USA.|University of Michigan Health System, Ann Arbor, MI, USA.
authors.forename: G W
authors.initials: GW
authors.lastname: Dalack
authors.affiliation: University of Michigan Department of Psychiatry, Ann Arbor, MI, USA.|University of Michigan Health System, Ann Arbor, MI, USA.
authors.forename: M I
authors.initials: MI
authors.lastname: Casher
authors.affiliation: University of Michigan Health System, Ann Arbor, MI, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Eappen
authors.affiliation: University of Michigan College of Pharmacy, Ann Arbor, MI, USA.|University of Michigan Health System, Ann Arbor, MI, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Bostwick
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000187:drug effects; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007297:Inpatients; D008297:Male; D050316:Medical Order Entry Systems; D001523:Mental Disorders / Q000188:drug therapy* / Q000378:metabolism*; D010595:Pharmacists; D011570:Psychiatry / Q000379:methods; D012189:Retrospective Studies
chemical_list: D014150:Antipsychotic Agents; D001786:Blood Glucose; D006442:Glycated Hemoglobin
keywords: computerized physician order entry system; metabolic monitoring; pharmacist; schizophrenia; second-generation antipsychotics