title: Postprandial dietary fatty acids exert divergent inflammatory responses in retinal-pigmented epithelium cells.
abstract: Postprandial triglyceride-rich lipoproteins (TRLs) lead to a complex series of events that are potentially oxidative and inflammatory. The main goal of this study was to characterize the influence of postprandial TRLs with different fatty acid compositions (mainly SFAs, MUFAs or MUFAs plus omega-3 PUFAs) on oxidative and inflammatory markers in RPE cells, which play a pivotal role in age-related macular degeneration (AMD). Compared to TRL-SFAs, TRL-MUFAs and TRL-MUFAs plus omega-3 PUFAs decreased the production of ROS and nitrite, and the gene expression and secretion of IL-1β, IL-6, TNF-α, IFNγ and VEGF. For the first time we show that postprandial TRLs are metabolic entities able to induce RPE oxidative stress and inflammation in a fatty acid-dependent manner, TRL-SFAs ⋙ TRL-MUFAs = TRL-MUFAs plus omega-3 PUFAs. These exciting findings open new opportunities for developing novel nutritional strategies with olive oil as the principal dietary source of oleic acid to prevent the development and progression of AMD.
authors.affiliation: Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC, Ctra. de Utrera Km. 1, 41013 Seville, Spain. delapaz@us.es.
authors.forename: Sergio
authors.initials: S
authors.lastname: Montserrat-de la Paz
authors.affiliation: Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC, Ctra. de Utrera Km. 1, 41013 Seville, Spain. delapaz@us.es.
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Naranjo
authors.affiliation: Department of Pharmacology, School of Pharmacy, University of Seville, Profesor Garcia Gonzalez 2, 41012 Seville, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Bermudez
authors.affiliation: Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC, Ctra. de Utrera Km. 1, 41013 Seville, Spain. delapaz@us.es.
authors.forename: Sergio
authors.initials: S
authors.lastname: Lopez
authors.affiliation: Laboratory of Olive Oil Quality, Purity and Technology, Instituto de la Grasa, CSIC, Ctra. de Utrera Km. 1, 41013 Seville, Spain.
authors.forename: Wenceslao
authors.initials: W
authors.lastname: Moreda
authors.affiliation: Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC, Ctra. de Utrera Km. 1, 41013 Seville, Spain. delapaz@us.es.
authors.forename: Rocio
authors.initials: R
authors.lastname: Abia
authors.affiliation: Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC, Ctra. de Utrera Km. 1, 41013 Seville, Spain. delapaz@us.es.
authors.forename: Francisco J G
authors.initials: FJ
authors.lastname: Muriana
mesh_terms: D000893:Anti-Inflammatory Agents / Q000276:immunology* / Q000378:metabolism; D002460:Cell Line; D004847:Epithelial Cells / Q000276:immunology* / Q000378:metabolism; D005227:Fatty Acids / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000276:immunology; D008074:Lipoproteins / Q000276:immunology; D008268:Macular Degeneration / Q000276:immunology* / Q000378:metabolism; D019518:Postprandial Period / Q000276:immunology; D017382:Reactive Oxygen Species / Q000276:immunology; D012160:Retina / Q000276:immunology* / Q000378:metabolism; D014280:Triglycerides / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D005227:Fatty Acids; D015850:Interleukin-6; D008074:Lipoproteins; D017382:Reactive Oxygen Species; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; C030087:lipoprotein triglyceride