title: Increased ischemia-modified albumin and malondialdehyde levels in videothoracoscopic surgery.
abstract: BACKGROUND
  Videothoracoscopic surgery leads to general organ hypoperfusion by reducing mean arterial pressure, systemic vascular resistance, and end-diastolic volume index. Oxidative stress occurs as a result of hypoperfusion. Evaluation of the short-term effects of videothoracoscopic sympathectomy on serum ischemia-modified albumin (IMA), malondialdehyde (MDA), and nitric oxide (NO) levels in patients with primary hyperhidrosis was aimed.
  
  
  METHODS
  Twenty-six patients who underwent videothoracoscopic surgery were contributed in this study. Venous blood samples were obtained from these patients 1 h before and after the surgery. IMA, MDA, and NO levels were measured in serum samples by colorimetric methods. Albumin concentrations were also measured for each sample, and albumin-adjusted IMA levels were calculated.
  
  
  RESULTS
  Postoperative IMA, albumin-adjusted IMA, and MDA values were significantly higher compared to the preoperative values (P = 0.003, 0.027, 0.018, respectively). However, postoperative NO levels were lower than the preoperative values (P = 0.002). There was no significant difference between pre- and postoperative albumin concentrations, and there was no significant correlation between the parameters tested.
  
  
  CONCLUSIONS
  We can conclude that elevation in MDA and IMA levels after videothoracoscopic surgery was caused by increased oxidative stress due to minimal ischemia-reperfusion injury after the infusion of CO2 during the surgical process. Videothoracoscopic sympathectomy operation causes a decrease in NO production, and this should be taken in consideration when evaluating nitrosative stress in videothoracoscopic surgery.
authors.affiliation: Department of Biochemistry, Medical Faculty, Mevlana University, Konya, Turkey.
authors.forename: Mufide
authors.initials: M
authors.lastname: Oncel
authors.affiliation: Department of Biochemistry, Medical Faculty, Mevlana University, Konya, Turkey.
authors.forename: Aysel
authors.initials: A
authors.lastname: Kiyici
authors.affiliation: Department of Thoracic Surgery, Medical Faculty, Selcuk University, Selcuklu, Konya, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Oncel
authors.affiliation: Department of Thoracic Surgery, Medical Faculty, Selcuk University, Selcuklu, Konya, Turkey.
authors.forename: Guven Sadi
authors.initials: GS
authors.lastname: Sunam
authors.affiliation: Department of Biochemistry, Medical Faculty, Mevlana University, Konya, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Sahin
authors.affiliation: Department of Biochemistry, Medical Faculty, Mevlana University, Konya, Turkey.
authors.forename: Bahattin
authors.initials: B
authors.lastname: Adam
keywords: Ischemia modified albumin; malondialdehyde; nitric oxide; videothoracoscopic surgery