title: [CLINICAL FEATURE OF NONALCOHOLIC STEATOHEPATITIS, ASSOCIATED WITH CHRONIC CONSTIPATION].
abstract: OBJECTIVE
  to conduct a comprehensive assessment of features of combined course NASH and functional constipation using laboratory parameters, the data of instrumental methods, indicators of quality of life in comparison with patients with Nash without proven pathology of the intestine.
  
  
  METHODS
  In the cross-sectional comparative study involving 102 patients with NASH, among which identified patients with functional constipation, there were formed two groups: study group (patients with NASH and functional constipation) and comparison group (patients with NASH without pathology of the intestine). All patients underwent a comprehensive assessment of laboratory data (markers of cytolysis, cholestasis, lipid and carbohydrate metabolism), results of instrumental methods (hydrogen breath test), quality of life (questionnaire SF-36).
  
  
  RESULTS
  All patients with NASH, regardless of the presence of functional bowel pathology was characterized by hyperlipidemia with a tendency to lower HDL and raise LDL with normal levels of triglycerides, fasting hyperglycemia, increased postprandial glucose, glycated hemoglobin and HOMA--IR higher than normal values and the availability of the SIBO. NASH is often associated with functional constipation (68.6%). Patients with functional constipation and NASH have a significantly higher average level of ALT (127.3 ± 58.4 U/I in the control group and to 103.5 ± 74.6 U/I in the comparison group, p = 0.02), more frequent association with the SIBO (65.7% in the main group opposed to 43.7% in the comparison group, p = 0.014) and a lower quality of life compared with patients without pathology of the intestine.
  
  
  CONCLUSIONS
  NASH has frequent association with functional constipation, worsens its course, resulting in a significant increase in the level of the marker of cytolysis (ALT), the more expressed SIBO and a palpable decline in the quality of life of patients, therefore the impaired intestinal function in these patients requires close attention.
authors.forename: E A
authors.initials: EA
authors.lastname: Maevskaya
authors.forename: I V
authors.initials: IV
authors.lastname: Mayev
authors.forename: Yu A
authors.initials: YA
authors.lastname: Kucheryavyy
authors.forename: A N
authors.initials: AN
authors.lastname: Kazyulin
authors.forename: N Yu
authors.initials: NY
authors.lastname: Stukova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D003248:Constipation / Q000097:blood / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000150:complications / Q000503:physiopathology; D011788:Quality of Life
chemical_list: D015415:Biomarkers