title: Counterion effects on nano-confined metal-drug-DNA complexes.
abstract: We have explored morphology of DNA molecules bound with Cu complexes of piroxicam (a non-steroidal anti-inflammatory drug) molecules under one-dimensional confinement of thin films and have studied the effect of counterions present in a buffer. X-ray reflectivity at and away from the Cu K absorption edge and atomic force microscopy studies reveal that confinement segregates the drug molecules preferentially in a top layer of the DNA film, and counterions enhance this segregation.
authors.affiliation: Surface Physics and Material Science Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India; present affiliation: Soft Condensed Matter Department, Raman Research Institute, Bangalore 560080, India.
authors.forename: Nupur
authors.initials: N
authors.lastname: Biswas
authors.affiliation: Chemical Science Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.
authors.forename: Sreeja
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: Surface Physics and Material Science Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.
authors.forename: Alokmay
authors.initials: A
authors.lastname: Datta
authors.affiliation: Chemical Science Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.
authors.forename: Munna
authors.initials: M
authors.lastname: Sarkar
authors.affiliation: Surface Physics and Material Science Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.
authors.forename: Mrinmay K
authors.initials: MK
authors.lastname: Mukhopadhyay
authors.affiliation: Center for Advanced Radiation Sources, University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Mrinal K
authors.initials: MK
authors.lastname: Bera
authors.affiliation: KENS & CMRC, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba 305-0801, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Seto
keywords: X-ray scattering; confinement; metal–drug–DNA composites; polyelectrolyte