title: 5-HTTLPR, victimization and ecological executive function of adolescents.
abstract: Executive function (EF) plays an important role in guiding peer relationship, school performance and behavior control. Children exposed to traumatic environments have been reported to perform poorer in EF tasks. We explored if the relationship between victimization and EF was dependent on the functional variation 5-HTTLPR in a non-clinical sample of adolescents. Data on demographics, victimization and daily life EF were collected from school students (Han Chinese, n=2125). All those reporting executive dysfunction (n=169), and classmate controls (n=208), were genotyped for the 5-HTTLPR. It was shown that the number of victimizations associated positively with executive dysfunction (ED). This association was particularly strong in those homozygous for the short allele of 5-HTTLPR, whilst a statistical 5-HTTLPR×victimization interaction on ED was found. Our findings suggest that adolescents with a genotype conferring a low 5-HTT activity are more vulnerable to a childhood adversity-associated ED in their daily life.
authors.affiliation: School of Nursing, Shandong University, Jinan 250012, China; Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden. Electronic address: liujiajia.sdu@hotmail.com.
authors.forename: JiaJia
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Nursing, Shandong University, Jinan 250012, China.
authors.forename: Fenglin
authors.initials: F
authors.lastname: Cao
authors.affiliation: School of Nursing, Shandong University, Jinan 250012, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: School of Nursing, Shandong University, Jinan 250012, China.
authors.forename: Fenglan
authors.initials: F
authors.lastname: Lou
authors.affiliation: Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Catharina
authors.initials: C
authors.lastname: Lavebratt
mesh_terms: D000293:Adolescent; D000483:Alleles; D058445:Bullying; D002648:Child; D019548:Crime Victims / Q000523:psychology*; D003430:Cross-Sectional Studies; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010379:Peer Group; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012931:Social Environment
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins
keywords: Adversity; Executive dysfunction; Genetic variation; G×E interaction; Serotonin