title: Prevention of Obesity and Type 2 Diabetes with Aged Citrus Peel (Chenpi) Extract.
abstract: Chenpi is the dry peel of the plant Citrus reticulata Blanco after an aging processing. It has been used as an antidigestive and anti-inflammatory traditional medicine, as well as culinary seasoning and dietary supplement, in China. However, its efficacy and underlying scientific mechanism have not been sufficiently investigated. Chenpi is uniquely enriched with a high content of 5-demethylated polymethoxyflavones (5-OH PMFs). The effect of chenpi extract on improving metabolic features was examined using high-fat diet (HFD)-induced obesity/diabetes mouse model. Oral administration of 0.25 and 0.5% chenpi extract in food over 15 weeks markedly prevented HFD-induced obesity, hepatic steatosis, and diabetic symptoms. The beneficial effect is associated with 5'-adenosine monophosphate-activated protein kinase (AMPK) activation in adipose tissue. Our results indicate that 5-OH PMFs-enriched chenpi extract is effective in preventing obesity and type 2 diabetes, and its effect might be related to improvement in lipid metabolism associated with activation of the AMPK pathway.
authors.affiliation: Department of Food Science, Rutgers University , 65 Dudley Road, New Brunswick, New Jersey 08901, United States.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Pharmacology, Rutgers University-Robert Wood Johnson Medical School , Piscataway, New Jersey 08854, United States.
authors.forename: Hanlin
authors.initials: H
authors.lastname: Tao
authors.affiliation: College of Food Science, South China Agricultural University , Guangzhou 510642, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Food Science, Rutgers University , 65 Dudley Road, New Brunswick, New Jersey 08901, United States.
authors.forename: Chi-Tang
authors.initials: CT
authors.lastname: Ho
authors.affiliation: Department of Pharmacology, Rutgers University-Robert Wood Johnson Medical School , Piscataway, New Jersey 08854, United States.
authors.forename: Shengkang
authors.initials: S
authors.lastname: Jin
authors.affiliation: Department of Food Science, Rutgers University , 65 Dudley Road, New Brunswick, New Jersey 08901, United States.
authors.forename: Qingrong
authors.initials: Q
authors.lastname: Huang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002957:Citrus / Q000737:chemistry*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry; D005638:Fruit / Q000737:chemistry; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007328:Insulin; C557482:chenpi
keywords: 5-demethylated polymethoxyflavones; chenpi; diabetes; insulin resistance; obesity