title: Dynamic Changes in Clinical Characteristics During an Outbreak of Human Adenovirus Serotype 55 in China.
abstract: To determine dynamic changes in clinical characteristics by examining an outbreak of adenovirus infection that occurred from December 20, 2012, to February 25, 2013, in Tianjin, China.
  
  
  
  Active surveillance for febrile respiratory illnesses was conducted, and medical records of patients were collected. Real-time quantitative polymerase chain reaction and sequencing were used for pathogen identification and viral genome study, respectively. Student's t-test was used to compare the mean values of normally distributed continuous variables. Mann-Whitney U or Kruskal-Wallis tests were used if continuous variables were not normally distributed. Pearson's chi-square test or Fisher's exact test was used to compare categorical variables.
  
  
  
  The outbreak was sourced from the index case diagnosed as the common cold on December 20, 2012; a total of 856 cases were reported in the following 66 days. The pathogen was identified as human adenovirus (HAdV) 55. The symptoms manifested differently in severe and mild cases. Routine blood examinations, liver function indexes, and heart function indexes showed different dynamic patterns over time in hospitalized patients.
  
  
  
  Clinical characteristics and laboratory examinations may reveal unique patterns over the course of HAdV-55 infection. (Disaster Med Public Health Preparedness. 2018;12:464-469).
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of Logistics University of Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Gao
authors.affiliation: 3The Logistics University of the Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Mao-Ti
authors.initials: MT
authors.lastname: Wei
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of Logistics University of Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Hao-Jun
authors.initials: HJ
authors.lastname: Fan
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of Logistics University of Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ding
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of Logistics University of Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of Logistics University of Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Zi-Quan
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of Logistics University of Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Yong-Zhong
authors.initials: YZ
authors.lastname: Zhang
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of Logistics University of Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Lv
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of Logistics University of Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Wen-Long
authors.initials: WL
authors.lastname: Dong
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of Logistics University of Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Shi-Ke
authors.initials: SK
authors.lastname: Hou
mesh_terms: D000256:Adenoviridae / Q000472:pathogenicity; D000258:Adenovirus Infections, Human / Q000145:classification* / Q000453:epidemiology; D000328:Adult; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D008297:Male; D010361:Patients / Q000145:classification*; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
keywords: clinical characteristics; dynamic changes; human adenovirus serotype 55; outbreak