title: Synthesis and neuroprotective activity of dictyoquinazol A and analogues.
abstract: A flexible and efficient synthesis of the neuroprotective alkaloid, dictyoquinazol A, is reported. Several structural analogues of the target molecule were produced, and the neuroprotective activity of this series of compounds was investigated using three different cell-based models of stroke. Several of the new compounds were found to have superior activity compared to the natural product. This work has established a new molecular scaffold that holds promise for a novel pharmaceutical treatment for stroke.
authors.affiliation: School of Chemistry, UNSW Australia, Sydney NSW 2052, Australia.
authors.forename: Yuvixza
authors.initials: Y
authors.lastname: Lizarme
authors.affiliation: School of Chemistry, UNSW Australia, Sydney NSW 2052, Australia.
authors.forename: Jonatan
authors.initials: J
authors.lastname: Wangsahardja
authors.affiliation: School of Chemistry, UNSW Australia, Sydney NSW 2052, Australia.
authors.forename: Gabriella M
authors.initials: GM
authors.lastname: Marcolin
authors.affiliation: School of Chemistry, UNSW Australia, Sydney NSW 2052, Australia.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Morris
authors.affiliation: School of Medical Sciences, UNSW Australia, Sydney NSW 2052, Australia. Electronic address: n.jones@unsw.edu.au.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Jones
authors.affiliation: School of Chemistry, UNSW Australia, Sydney NSW 2052, Australia. Electronic address: l.hunter@unsw.edu.au.
authors.forename: Luke
authors.initials: L
authors.lastname: Hunter
mesh_terms: D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D020521:Stroke / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D018696:Neuroprotective Agents; D011799:Quinazolines; C473161:dictyoquinazol A
keywords: Alkaloid; Natural product; Neuroprotective; Stroke