title: The Influence of Chemokine CXCR4 and Cyclooxygenase-2 in the Recurrence of Pterygium.
abstract: OBJECTIVE
  To investigate the role of CXCR4 and cyclooxygenase-2 in pterygium recurrence.
  
  
  METHODS
  A total of 18 primary and 9 recurrent pterygium samples were analyzed. Immunohistochemical staining using primary antibodies against cyclooxygenase-2 and CXCR4 was performed. The cyclooxygenase-2 and CXCR4 expressing cells were calculated separately on the epithelium and stroma. In addition, a correlation between the area of pterygium and CXCR4 and cyclooxygenase-2 levels was investigated.
  
  
  RESULTS
  In the primary pterygium group, cyclooxygenase-2 staining was more intense in the epithelium and more dominant in the stroma of the recurrence samples. The CXCR4 expression was more intense in the stroma of both groups. The highest CXCR4 expression was observed in the recurrent pterygium group. There was a strong correlation between the area of pterygium and CXCR4 and cyclooxygenase-2 of stroma.
  
  
  CONCLUSIONS
  CXCR4 and cyclooxygenase-2 may play an important role in the recurrence of pterygium.
authors.affiliation: a Department of Ophthalmology , Ozel Deniz Hospital , Izmir , Turkey.
authors.forename: Gonen
authors.initials: G
authors.lastname: Baser
authors.affiliation: b Department of Pathology , Sifa University , Izmir , Turkey.
authors.forename: Oya Nermin
authors.initials: ON
authors.lastname: Sivrikoz
authors.affiliation: c Department of Ophthalmology , Sifa University , Izmir , Turkey.
authors.forename: Eyyup
authors.initials: E
authors.lastname: Karahan
authors.affiliation: d Department of Ophthalmology , Sifa University , Izmir , Turkey.
authors.forename: Emine Seker
authors.initials: ES
authors.lastname: Un
authors.affiliation: d Department of Ophthalmology , Sifa University , Izmir , Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Yildirim
mesh_terms: D000328:Adult; D000368:Aged; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011625:Pterygium / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D019718:Receptors, CXCR4 / Q000378:metabolism*; D012008:Recurrence; D055815:Young Adult
chemical_list: C527276:CXCR4 protein, human; D019718:Receptors, CXCR4; D051546:Cyclooxygenase 2
keywords: CXCR4; cyclooxygenase-2; pterygium; recurrence