title: Efficient drug delivery using SiO2-layered double hydroxide nanocomposites.
abstract: MgAl-layered double hydroxide (MgAl-LDH) nanoparticles have great potentials in drug and siRNA delivery. In this work, we used a nanodot-coating strategy to prepare SiO2 dot-coated layered double hydroxide (SiO2@MgAl-LDH) nanocomposites with good dispersibility and controllable size for drug delivery. The optimal SiO2@MgAl-LDH nanocomposite was obtained by adjusting synthetic parameters including the mass ratio of MgAl-LDH to SiO2, the mixing temperature and time. The optimal SiO2@MgAl-LDH nanocomposite was shown to have SiO2 nanodots (10-15nm in diameter) evenly deposited on the surface of MgAl-LDHs (110nm in diameter) with the plate-like morphology and the average hydrodynamic diameter of 170nm. We further employed SiO2@MgAl-LDH nanocomposite as a nanocarrier to deliver methotrexate (MTX), a chemotherapy drug, to the human osteosarcoma cell (U2OS) and found that MTX delivered by SiO2@MgAl-LDH nanocomposite apparently inhibited the U2OS cell growth.
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Australia. Electronic address: l.li2@uq.edu.au.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Australia; School of Chemical Engineering, University of New South Wales, Sydney, NSW, 2052, Australia.
authors.forename: Zi
authors.initials: Z
authors.lastname: Gu
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Australia.
authors.forename: Wenyi
authors.initials: W
authors.lastname: Gu
authors.affiliation: Department of Chemical Engineering, Curtin University, Australia.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Australia. Electronic address: gordonxu@uq.edu.au.
authors.forename: Zhi Ping
authors.initials: ZP
authors.lastname: Xu
mesh_terms: D000535:Aluminum / Q000737:chemistry / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006878:Hydroxides / Q000737:chemistry* / Q000494:pharmacology; D008274:Magnesium / Q000737:chemistry / Q000494:pharmacology; D008727:Methotrexate / Q000737:chemistry / Q000494:pharmacology*; D053761:Nanocomposites / Q000737:chemistry*; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry / Q000494:pharmacology; D013499:Surface Properties
chemical_list: D006878:Hydroxides; D012822:Silicon Dioxide; D000535:Aluminum; D008274:Magnesium; D008727:Methotrexate
keywords: Drug delivery; Functionalization; Layered double hydroxide (LDH); Nanocomposites; Self-assembly