title: Pulmonary atypical carcinoid in a patient with Cowden syndrome.
abstract: Cowden syndrome is a phosphatase and tensin homologue on chromosome ten (PTEN) hamartoma tumour syndrome. The loss of function of the PTEN protein is associated with the risk of development and progression of several types of tumours, such as pulmonary neuroendocrine tumours and carcinoids. We present a 65-year old male non-smoker, who was diagnosed with Cowden syndrome and had a pulmonary tumour. He underwent wedge resection via video-assisted thoracoscopic surgery and was histopathologically diagnosed with an atypical carcinoid. To our knowledge, this is the first report on a pulmonary atypical carcinoid in a patient with Cowden syndrome. The present findings suggest a potential link between phosphoinositide-3 kinase/protein kinase B signalling in Cowden syndrome and the development of pulmonary neuroendocrine tumours, such as carcinoids.
authors.affiliation: Division of Chest Surgery, Department of Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan tsune824@nifty.com.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tsunezuka
authors.affiliation: Division of Chest Surgery, Department of Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Abe
authors.affiliation: Division of Chest Surgery, Department of Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Shimada
authors.affiliation: Division of Chest Surgery, Department of Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Inoue
mesh_terms: D000368:Aged; D001706:Biopsy; D002276:Carcinoid Tumor / Q000175:diagnosis / Q000601:surgery*; D018450:Disease Progression; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000601:surgery*; D011013:Pneumonectomy / Q000379:methods*; D020775:Thoracic Surgery, Video-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed
keywords: Atypical pulmonary carcinoid; Cowden syndrome; Phosphatase and tensin homologue on chromosome ten