title: Catalytic Asymmetric Direct Aldol Reaction of α-Alkyl Azlactones and Aliphatic Aldehydes.
abstract: An unprecedented highly diastereoselective and enantioselective aldol reaction of α-alkyl azlactones and aliphatic aldehydes was achieved with cinchona alkaloid catalysts. To our knowledge, this reaction provides the first useful catalytic asymmetric access toward β-hydroxy-α-amino acids bearing alkyl substituents, which are structural motifs embedded in many natural products.
authors.affiliation: Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, United States.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, United States.
authors.forename: Li
authors.initials: L
authors.lastname: Deng