title: Decoding the RNA structurome.
abstract: Structures of RNA molecules are essential for their architectural, regulatory, and catalytic functions. Recent advances in high throughput sequencing enabled the development of methods for probing RNA structures on a transcriptome-wide scale-termed the RNA structurome. Here we review the state-of-the-art technologies for probing the RNA structurome, and highlight insights gained from these studies. We also point out the limits of current methods and discuss potential directions for future improvements.
authors.affiliation: Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, United States.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, United States. Electronic address: howchang@stanford.edu.
authors.forename: Howard Y
authors.initials: HY
authors.lastname: Chang
mesh_terms: D019295:Computational Biology / Q000379:methods; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000235:genetics; D013329:Structure-Activity Relationship; D059467:Transcriptome
chemical_list: D012313:RNA