title: A model-based analysis of physiological properties of the striatal medium spiny neuron.
abstract: As the principal cell of the striatum, medium spiny neurons (MSNs) are closely associated with various motor dysfunctional diseases. In this paper, we describe an electric compartment model constructed in NEURON with a realistic morphology. Based on a 554-compartment computational model, we researched the influence of external current stimuli, different ions conductance, and the removal of partial dendrites on the physiological properties of the MSN. The main results are the following: (1) in the case of external current stimuli, various firing patterns appear in the MSN and the model produces a clear period-adding bifurcation phenomenon; (2) the effect of distinct types of ion channels vary and significant differences in discharge rhythm exist even among ion channels of the same type; (3) the closer the removed dendrite was to the soma, the larger the impact this had on the discharge pattern of the MSN.
authors.affiliation: 1 School of Mathematics, South China University of Technology , Guangzhou 510640, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Shenquan
authors.initials: S
authors.lastname: Liu
authors.forename: Hongchu
authors.initials: H
authors.lastname: Wang
authors.forename: Niansheng
authors.initials: N
authors.lastname: Ju
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D055592:Biophysical Phenomena / Q000502:physiology; D001703:Biophysics; D003198:Computer Simulation; D003342:Corpus Striatum / Q000166:cytology*; D003712:Dendrites / Q000502:physiology; D004558:Electric Stimulation; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008959:Models, Neurological; D009474:Neurons / Q000166:cytology / Q000502:physiology*
chemical_list: D007473:Ion Channels
keywords: Discharge rhythm; Interspike intervals (ISI); Medium spiny neuron (MSN); The number of spikes per burst (NS)