title: Water-Soluble Pd-Imidate Complexes: Broadly Applicable Catalysts for the Synthesis of Chemically Modified Nucleosides via Pd-Catalyzed Cross-Coupling.
abstract: A broadly applicable catalyst system consisting of water-soluble Pd--imidate complexes has been enployed for the Suzuki-Miyaura cross-coupling of four different nucleosides in water under mild conditions. The efficient nature of the catalyst system also allowed its application in developing a microwave-assisted protocol with the purpose of expediting the catalytic reaction. Preliminary mechanistic studies, assisted by catalyst poison tests and stoichiometric tests performed using an electrospray ionization spectrometer, revealed the possible presence of a homotopic catalyst system.
authors.affiliation: Institute of Chemical Technology , Mumbai Nathalal Road, Matunga, Mumbai 400019, India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Gayakhe
authors.affiliation: Institute of Chemical Technology , Mumbai Nathalal Road, Matunga, Mumbai 400019, India.
authors.forename: Ajaykumar
authors.initials: A
authors.lastname: Ardhapure
authors.affiliation: Institute of Chemical Technology , Mumbai Nathalal Road, Matunga, Mumbai 400019, India.
authors.forename: Anant R
authors.initials: AR
authors.lastname: Kapdi
authors.affiliation: Rasayan, Inc. 2802 Crystal Ridge Road, Encinitas, California 92024-6615, United States.
authors.forename: Yogesh S
authors.initials: YS
authors.lastname: Sanghvi
authors.affiliation: Departamento de Ingeniería Minera, Geológica y Cartográfica, Universidad Politécnica de Cartagena, Área de Química Inorgánica, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad Politécnica de Cartagena , 30203 Cartagena, Spain.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Serrano
authors.affiliation: Departamento de Ingeniería Minera, Geológica y Cartográfica, Universidad Politécnica de Cartagena, Área de Química Inorgánica, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad Politécnica de Cartagena , 30203 Cartagena, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: García
authors.affiliation: Departamento de Ingeniería Minera, Geológica y Cartográfica, Universidad Politécnica de Cartagena, Área de Química Inorgánica, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad Politécnica de Cartagena , 30203 Cartagena, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Pérez
authors.affiliation: Departamento de Química Inorgánica, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia , 30071 Murcia, Spain.
authors.forename: Joaquím
authors.initials: J
authors.lastname: García
authors.affiliation: Departamento de Química Inorgánica, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia , 30071 Murcia, Spain.
authors.forename: Gregorio
authors.initials: G
authors.lastname: Sánchez
authors.affiliation: Ernst-Moritz-Arndt-Universität Greifswald, Institut für Biochemie , Felix-Hausdorff-Strasse 4, 17489 Greifswald, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Fischer
authors.affiliation: Ernst-Moritz-Arndt-Universität Greifswald, Institut für Biochemie , Felix-Hausdorff-Strasse 4, 17489 Greifswald, Germany.
authors.forename: Carola
authors.initials: C
authors.lastname: Schulzke