title: Parvimonas micra: A rare cause of native joint septic arthritis.
abstract: Parvimonas micra is a fastidious, anaerobic, gram positive coccus, which is found in normal human oral and gastrointestinal flora. It has also been known as Peptostreptococcus micros and Micromonas micros with its most recent re-classification in 2006. It has been described in association with hematogenous seeding of prosthetic joints [1,2]. Several cases of discitis and osteomyelitis have been described in association with dental procedures and periodontal disease often with a subacute presentation. However, cases of native joint septic arthritis are limited [3-5]. Per our literature review, there is one case of native knee septic arthritis described in 1999, with a prolonged time to diagnosis and treatment due to difficulty culturing P. micra. The previously reported patient experienced significant joint destruction and morbidity [6]. Advances in culture techniques and new methods of organism identification including MALDI-TOF and 16s rRNA sequencing have lead to increased identification of this organism, which may be a more frequent bone and joint pathogen than previously realized.
authors.affiliation: Yale University School of Medicine, United States. Electronic address: ADAM.BAGHBAN@gmail.com.
authors.forename: Adam
authors.initials: A
authors.lastname: Baghban
authors.affiliation: Yale University School of Medicine, United States.
authors.forename: Shaili
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000368:Aged; D000667:Ampicillin / Q000627:therapeutic use; D000693:Anaerobiosis; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D015373:Bacterial Typing Techniques; D002981:Clindamycin / Q000627:therapeutic use; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D006801:Humans; D007719:Knee Joint / Q000382:microbiology* / Q000473:pathology; D008297:Male; D010462:Peptostreptococcus / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013407:Sulbactam / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin; C035444:sultamicillin; D000667:Ampicillin; D013407:Sulbactam
keywords: Knee; Micromonas; Native; Osteomyelitis; Parvimonas; Peptostreptococcus; Septic joint