title: Transcriptional Responses to the Auxin Hormone.
abstract: Auxin is arguably the most important signaling molecule in plants, and the last few decades have seen remarkable breakthroughs in understanding its production, transport, and perception. Recent investigations have focused on transcriptional responses to auxin, providing novel insight into the functions of the domains of key transcription regulators in responses to the hormonal cue and prominently implicating chromatin regulation in these responses. In addition, studies are beginning to identify direct targets of the auxin-responsive transcription factors that underlie auxin modulation of development. Mechanisms to tune the response to different auxin levels are emerging, as are first insights into how this single hormone can trigger diverse responses. Key unanswered questions center on the mechanism for auxin-directed transcriptional repression and the identity of additional determinants of auxin response specificity. Much of what has been learned in model plants holds true in other species, including the earliest land plants.
authors.affiliation: Laboratory of Biochemistry, Wageningen University, 6703 HA Wageningen, The Netherlands; email: dolf.weijers@wur.nl.
authors.forename: Dolf
authors.initials: D
authors.lastname: Weijers
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104; email: wagnerdo@sas.upenn.edu.
authors.forename: Doris
authors.initials: D
authors.lastname: Wagner
mesh_terms: D002843:Chromatin / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D007210:Indoleacetic Acids / Q000378:metabolism*; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D002843:Chromatin; D007210:Indoleacetic Acids; D014157:Transcription Factors
keywords: ARF; auxin; chromatin; development; gene expression; specificity