title: [Hyperleptinemia associated with ischemic stroke].
abstract: BACKGROUND
  The major risk factors for stroke are obesity, diabetes mellitus, systemic arterial hypertension (SAH) and dyslipidemia. In 1994 leptin was identifies as adipokine produced by adipose tissue. Its main action is the regulation of energy balance. Currently, hyperleptinemia is associated with cardiovascular disease.
  
  
  OBJECTIVE
  To determine the association between serum leptin and stroke in patients with SAH.
  
  
  METHODS
  We determined serum leptin in subjects with stroke and SAH, and compared this with patients with SAH without stroke. We calculated Student t, χ², and odds ratio (OR) for quantitative and qualitative variables.
  
  
  RESULTS
  60 subjects were recruited, 30 subjects per group. Considering a value>3.93 ng/ml as hyperleptinemia, it also was found a t=2.8 (p=0.007), and χ² with one degree of freedom of 10.82 (p=0.001), obtaining an OR of 3.05 for the development of stroke in the presence of elevated leptin (95% CI: 0.9-9.6; p=0.05).
  
  
  CONCLUSIONS
  Hyperleptinemia is more common in patients with stroke than in those without this condition. But the question remains whether hyperleptinemia is a stroke risk factor or protective factor.
authors.affiliation: Servicio de Medicina Interna, Hospital General Ticomán, Secretaría de Salud del Distrito Federal, México, D.F., México.
authors.forename: Jorge Luis
authors.initials: JL
authors.lastname: García-Sánchez
authors.affiliation: Servicio de Medicina Interna, Hospital General Xoco, Secretaría de Salud del Distrito Federal México, D.F., México.
authors.forename: Nayeli Gabriela
authors.initials: NG
authors.lastname: Jiménez-Saab
authors.affiliation: Servicio de Medicina Interna, Hospital General Iztapalapa, Secretaría de Salud del Distrito Federal México, D.F., México.
authors.forename: Jesús
authors.initials: J
authors.lastname: Guerrero-González
authors.affiliation: Laboratorio de Biomedicina, Centro de Investigación y Estudios Avanzados (CINVESTAV), Instituto Politécnico Nacional, México, D.F., México.
authors.forename: César Iván
authors.initials: CI
authors.lastname: Elizalde-Barrera
authors.affiliation: Servicio de Medicina Interna, Hospital General Ticomán, Secretaría de Salud del Distrito Federal, México, D.F., México.
authors.forename: Martín
authors.initials: M
authors.lastname: de Jesús Reyna-Ramírez
authors.affiliation: Servicio de Medicina Interna, Hospital General Ticomán, Secretaría de Salud del Distrito Federal, México, D.F., México.
authors.forename: Mauricio Eduardo
authors.initials: ME
authors.lastname: Rubio-Sánchez
authors.affiliation: Servicio de Medicina Interna, Hospital General Ticomán, Secretaría de Salud del Distrito Federal, México, D.F., México.
authors.forename: Andrés
authors.initials: A
authors.lastname: Ledesma-Velázquez
authors.affiliation: Servicio de Medicina Interna, Hospital General Ticomán, Secretaría de Salud del Distrito Federal, México, D.F., México.
authors.forename: Eduardo Adolfo
authors.initials: EA
authors.lastname: Montaño-Alonso
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000097:blood* / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000209:etiology*
chemical_list: D020738:Leptin