title: Access to the Parent Tetrakis(pyridine)gold(III) Trication, Facile Formation of Rare Au(III) Terminal Hydroxides, and Preliminary Studies of Biological Properties.
abstract: In this paper we report on the use of [NO][BF4] to access tricationic tetrakis(pyridine)gold(III) from Au powder, a species inaccessible using the more traditional (tetrahydrothiophene)AuCl route. It is then demonstrated that this family of compounds can be used to access new terminal Au(III) hydroxides, a challenging class of compounds, and the first crystallographically characterized examples employing bidentate ligands. Finally, preliminary biological studies indicate good activity for derivatives featuring polydentate ligands against the HeLa and PC3 cell lines but also strong inhibition of primary HUVEC cells.
authors.affiliation: Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University , Melbourne, Victoria 3086, Australia.
authors.forename: Robert
authors.initials: R
authors.lastname: Corbo
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University , Melbourne, Victoria 3086, Australia.
authors.forename: Gemma F
authors.initials: GF
authors.lastname: Ryan
authors.affiliation: Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University , Melbourne, Victoria 3086, Australia.
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Haghighatbin
authors.affiliation: Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University , Melbourne, Victoria 3086, Australia.
authors.forename: Conor F
authors.initials: CF
authors.lastname: Hogan
authors.affiliation: Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University , Melbourne, Victoria 3086, Australia.
authors.forename: David J D
authors.initials: DJ
authors.lastname: Wilson
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University , Melbourne, Victoria 3086, Australia.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Hulett
authors.affiliation: Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University , Melbourne, Victoria 3086, Australia.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Barnard
authors.affiliation: Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University , Melbourne, Victoria 3086, Australia.
authors.forename: Jason L
authors.initials: JL
authors.lastname: Dutton
mesh_terms: D006046:Gold / Q000737:chemistry*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D006878:Hydroxides / Q000737:chemistry; D007287:Inorganic Chemicals / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D006878:Hydroxides; D007287:Inorganic Chemicals; D011725:Pyridines; D006046:Gold; C023666:pyridine