title: The efficiency of O-(beta-hydroxyethyl)-rutosides in reducing the incidence of superficial venous insufficiency in patients with calf muscle pump dysfunction.
abstract: Objective We aimed to evaluate the efficiency of O-(beta-Hydroxyethyl)-rutosides (Oxerutin) in reducing the incidence of venous system disease among patients with calf muscle pump dysfunction secondary to immobilization due to lower-limb fractures. Methods A total of 60 patients with lower-limb fractures and immobilized in plaster casts were included in this study randomized into control (n = 30; mean: 30.37 ± 6.03 years; 73.3% males; no treatment) and experiment (n = 30; mean: 31.67 ± 4.76 years; 66.6% males; Oxerutin, 500 mg po q12hr) treatment groups. Doppler ultrasound was performed to evaluate the effect of oxerutin on the alterations in the venous circulation. Results Patients in the control group were determined to be more commonly affected from the below-knee immobilization in terms of venous dysfunction in the great saphenous vein in the below-knee region when compared with the patients in the oxerutin treatment group (46.7 vs. 13.3%, respectively; p = 0.011). Incidence of reflux in the small saphenous vein was more common in the control group during the healing period when compared with the experiment group (40.0 vs. 10.0%, respectively; p = 0.017). None of the patients developed venous thrombosis. Conclusions In conclusion, the impairment of the lower extremity muscle pump should be considered as an important risk factor for venous disease, and should be evaluated. O-(beta-Hydroxyethyl)-rutosides during 6-8 week cast immobilization for a lower limb fracture may be an effective prophylactic regimen in reducing the incidence of reflux in the below-knee superficial veins.
authors.affiliation: 1 Department of Cardiovascular Surgery, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Cenk Eray
authors.initials: CE
authors.lastname: Yildiz
authors.affiliation: 2 Department of Cardiology, Near East University Faculty of Medicine, Nicosia, Cyprus.
authors.forename: Cenk
authors.initials: C
authors.lastname: Conkbayir
authors.affiliation: 3 Department of Radiology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Eldeniz
authors.initials: E
authors.lastname: Huseynov
authors.affiliation: 4 Department of Cardiovascular Surgery, Istanbul University Medical Faculty, Istanbul, Turkey.
authors.forename: Omer Ali
authors.initials: OA
authors.lastname: Sayin
authors.affiliation: 5 Department of Orthopedics and Traumatology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Okan
authors.initials: O
authors.lastname: Tok
authors.affiliation: 5 Department of Orthopedics and Traumatology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Kaynak
authors.affiliation: 3 Department of Radiology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Cebi
authors.affiliation: 4 Department of Cardiovascular Surgery, Istanbul University Medical Faculty, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ugurlucan
authors.affiliation: 3 Department of Radiology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Kantarci
authors.affiliation: 5 Department of Orthopedics and Traumatology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Muharrem
authors.initials: M
authors.lastname: Inan
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005592:Fracture Fixation / Q000009:adverse effects*; D006801:Humans; D006896:Hydroxyethylrutoside / Q000008:administration & dosage / Q000031:analogs & derivatives*; D015994:Incidence; D007869:Leg Injuries / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D008297:Male; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000517:prevention & control; D011446:Prospective Studies; D012501:Saphenous Vein / Q000000981:diagnostic imaging / Q000503:physiopathology; D018615:Ultrasonography, Doppler, Color; D014689:Venous Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D006896:Hydroxyethylrutoside; C005865:troxerutin
keywords: Calf muscle pump function; Doppler ultrasound; vascular medicine