title: The Translational Genomics Core at Partners Personalized Medicine: Facilitating the Transition of Research towards Personalized Medicine.
abstract: The Translational Genomics Core (TGC) at Partners Personalized Medicine (PPM) serves as a fee-for-service core laboratory for Partners Healthcare researchers, providing access to technology platforms and analysis pipelines for genomic, transcriptomic, and epigenomic research projects. The interaction of the TGC with various components of PPM provides it with a unique infrastructure that allows for greater IT and bioinformatics opportunities, such as sample tracking and data analysis. The following article describes some of the unique opportunities available to an academic research core operating within PPM, such the ability to develop analysis pipelines with a dedicated bioinformatics team and maintain a flexible Laboratory Information Management System (LIMS) with the support of an internal IT team, as well as the operational challenges encountered to respond to emerging technologies, diverse investigator needs, and high staff turnover. In addition, the implementation and operational role of the TGC in the Partners Biobank genotyping project of over 25,000 samples is presented as an example of core activities working with other components of PPM.
authors.affiliation: Partners HealthCare Personalized Medicine, 65 Landsdowne Street, Cambridge, MA 02139, USA. ablau@partners.org.
authors.forename: Ashley
authors.initials: A
authors.lastname: Blau
authors.affiliation: Partners HealthCare Personalized Medicine, 65 Landsdowne Street, Cambridge, MA 02139, USA. abrown13@partners.org.
authors.forename: Alison
authors.initials: A
authors.lastname: Brown
authors.affiliation: Partners HealthCare Personalized Medicine, 65 Landsdowne Street, Cambridge, MA 02139, USA. lmahanta@partners.org.
authors.forename: Lisa
authors.initials: L
authors.lastname: Mahanta
authors.affiliation: Partners HealthCare Personalized Medicine, 65 Landsdowne Street, Cambridge, MA 02139, USA. samr@partners.org.|Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. samr@partners.org.
authors.forename: Sami S
authors.initials: SS
authors.lastname: Amr
keywords: academic core facility; genomics services; genotyping; seamless workflows; translational genomics core