title: A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation.
abstract: Selection of an optimal donor pancreas is the first key task for successful islet isolation. We conducted a retrospective multicenter study in 11 centers in North America to develop an islet donor scoring system using donor variables. The data set consisting of 1,056 deceased donors was used for development of a scoring system to predict islet isolation success (defined as postpurification islet yield >400,000 islet equivalents). With the aid of univariate logistic regression analyses, we developed the North American Islet Donor Score (NAIDS) ranging from 0 to 100 points. The c index in the development cohort was 0.73 (95% confidence interval 0.70-0.76). The success rate increased proportionally as the NAIDS increased, from 6.8% success in the NAIDS < 50 points to 53.7% success in the NAIDS ≥ 80 points. We further validated the NAIDS using a separate set of data consisting of 179 islet isolations. A comparable outcome of the NAIDS was observed in the validation cohort. The NAIDS may be a useful tool for donor pancreas selection in clinical practice. Apart from its utility in clinical decision making, the NAIDS may also be used in a research setting as a standardized measurement of pancreas quality.
authors.affiliation: Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL.
authors.forename: Ling-Jia
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: Clinical Islet Transplant Program, University of Alberta and Alberta Health Services, Edmonton, Alberta, Canada.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kin
authors.affiliation: Clinical Islet Transplant Program, University of Alberta and Alberta Health Services, Edmonton, Alberta, Canada.
authors.forename: Doug
authors.initials: D
authors.lastname: O'Gorman
authors.affiliation: Clinical Islet Transplant Program, University of Alberta and Alberta Health Services, Edmonton, Alberta, Canada.
authors.forename: A M James
authors.initials: AMJ
authors.lastname: Shapiro
authors.affiliation: Baylor Simmons Transplant Institute, Dallas, TX.
authors.forename: Bashoo
authors.initials: B
authors.lastname: Naziruddin
authors.affiliation: Baylor Simmons Transplant Institute, Dallas, TX.
authors.forename: Morihito
authors.initials: M
authors.lastname: Takita
authors.affiliation: Baylor Simmons Transplant Institute, Dallas, TX.
authors.forename: Marlon F
authors.initials: MF
authors.lastname: Levy
authors.affiliation: UCSF Transplantation Surgery, University of California-San Francisco, CA.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Posselt
authors.affiliation: UCSF Transplantation Surgery, University of California-San Francisco, CA.
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Szot
authors.affiliation: Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL.
authors.forename: Omid
authors.initials: O
authors.lastname: Savari
authors.affiliation: UIC Cell Isolation Program, University of Illinois at Chicago, Chicago, IL.
authors.forename: Barbara
authors.initials: B
authors.lastname: Barbaro
authors.affiliation: UIC Cell Isolation Program, University of Illinois at Chicago, Chicago, IL.
authors.forename: James
authors.initials: J
authors.lastname: McGarrigle
authors.affiliation: UIC Cell Isolation Program, University of Illinois at Chicago, Chicago, IL.
authors.forename: Chun Chieh
authors.initials: CC
authors.lastname: Yeh
authors.affiliation: UIC Cell Isolation Program, University of Illinois at Chicago, Chicago, IL.
authors.forename: Jose
authors.initials: J
authors.lastname: Oberholzer
authors.affiliation: Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
authors.forename: Ji
authors.initials: J
authors.lastname: Lei
authors.affiliation: Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
authors.forename: Moh
authors.initials: M
authors.lastname: Lian
authors.affiliation: Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
authors.forename: James F
authors.initials: JF
authors.lastname: Markmann
authors.affiliation: Diabetes Research Institute, cGMP Cell Processing Facility, University of Miami Miller School of Medicine, Miami, FL.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Alvarez
authors.affiliation: Diabetes Research Institute, cGMP Cell Processing Facility, University of Miami Miller School of Medicine, Miami, FL.
authors.forename: Elina
authors.initials: E
authors.lastname: Linetsky
authors.affiliation: Diabetes Research Institute, cGMP Cell Processing Facility, University of Miami Miller School of Medicine, Miami, FL.
authors.forename: Camillo
authors.initials: C
authors.lastname: Ricordi
authors.affiliation: Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN.
authors.forename: A N
authors.initials: AN
authors.lastname: Balamurugan
authors.affiliation: Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN.
authors.forename: Gopalakrishnan
authors.initials: G
authors.lastname: Loganathan
authors.affiliation: Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Wilhelm
authors.affiliation: Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN.
authors.forename: Bernhard J
authors.initials: BJ
authors.lastname: Hering
authors.affiliation: Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA.
authors.forename: Rita
authors.initials: R
authors.lastname: Bottino
authors.affiliation: Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA.
authors.forename: Massimo
authors.initials: M
authors.lastname: Trucco
authors.affiliation: Division of Transplantation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Chengyang
authors.initials: C
authors.lastname: Liu
authors.affiliation: Division of Transplantation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Zaw
authors.initials: Z
authors.lastname: Min
authors.affiliation: Division of Transplantation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Yanjing
authors.initials: Y
authors.lastname: Li
authors.affiliation: Division of Transplantation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Ali
authors.initials: A
authors.lastname: Naji
authors.affiliation: Division of Organ Transplantation, University of Wisconsin, Madison, WI.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Fernandez
authors.affiliation: Division of Organ Transplantation, University of Wisconsin, Madison, WI.
authors.forename: Martynas
authors.initials: M
authors.lastname: Ziemelis
authors.affiliation: Division of Organ Transplantation, University of Wisconsin, Madison, WI.
authors.forename: Juan S
authors.initials: JS
authors.lastname: Danobeitia
authors.affiliation: Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL.
authors.forename: J Michael
authors.initials: JM
authors.lastname: Millis
authors.affiliation: Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL.
authors.forename: Piotr
authors.initials: P
authors.lastname: Witkowski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000601:surgery; D012189:Retrospective Studies; D014019:Tissue Donors; D055815:Young Adult