title: Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment.
abstract: A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.
authors.affiliation: EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation, University of Bath, Bath, BA2 7AY, UK. C.C.Wilson@bath.ac.uk and Department of Chemistry, University of Bath, Bath, BA2 7AY, UK.
authors.forename: Lauren R
authors.initials: LR
authors.lastname: Agnew
authors.affiliation: Department of Chemistry, University of Cape Town, Rondebosch, 7701, South Africa.
authors.forename: Dyanne L
authors.initials: DL
authors.lastname: Cruickshank
authors.affiliation: EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation, c/o Strathclyde Institute for Pharmacy and Biomedical Sciences, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1RD, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: McGlone
authors.affiliation: EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation, University of Bath, Bath, BA2 7AY, UK. C.C.Wilson@bath.ac.uk and Department of Chemistry, University of Bath, Bath, BA2 7AY, UK.
authors.forename: Chick C
authors.initials: CC
authors.lastname: Wilson