title: Impact of S100A4 Expression on Clinicopathological Characteristics and Prognosis in Pancreatic Cancer: A Meta-Analysis.
abstract: BACKGROUND
  The small Ca(2+)-binding protein S100A4 is identified as a metastasis-associated or metastasis-inducing protein in various types of cancer. The goal of this meta-analysis was to evaluate the relationship between S100A4 expression and clinicopathological characteristics and prognosis of patients with pancreatic cancer.
  
  
  METHODS
  A comprehensive literature search was carried out in the electronic databases PubMed and Chinese CNKI. Only the studies reporting the correlation between S100A4 expression and clinicopathological characteristics or overall survival (OS) of patients with pancreatic cancer are enrolled. Extracted data was analyzed using the RevMan 5.3 software to calculate the pooled relative risks (95% confidence interval, CI) for statistical analyses.
  
  
  RESULTS
  Seven studies including a total of 474 patients were enrolled into this meta-analysis. Negative expression of S100A4 was significantly associated with higher 3-year OS rate (RR = 3.92, 95% CI = 2.24-6.87, P < 0.0001), compared to S100A4-positive cases. Moreover, negative expression of S100A4 was also related to N0 stage for lymph node metastasis (RR = 2.15, 95% CI = 1.60-2.88, P < 0.0001). However, S100A4 expression was not significantly correlated with histological types and distant metastasis status.
  
  
  CONCLUSIONS
  S100A4 expression represents a potential marker for lymph node metastasis of pancreatic cancer and a potential unfavorable factor for prognosis of patients with this disease.
authors.affiliation: Department of Medical Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzong Clinical College of Fujian Medical University, Fujian 350025, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Medical Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzong Clinical College of Fujian Medical University, Fujian 350025, China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Medical Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzong Clinical College of Fujian Medical University, Fujian 350025, China.
authors.forename: Yufang
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Medical Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzong Clinical College of Fujian Medical University, Fujian 350025, China.
authors.forename: Li
authors.initials: L
authors.lastname: Song
authors.affiliation: Department of Medical Oncology, Fuzhou General Hospital of Nanjing Military Command, Medical College Xiamen University, Xiamen 350025, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Department of Medical Oncology, Chinese People's Liberation Army 476th Hospital, Fujian 350002, China.
authors.forename: Danzhen
authors.initials: D
authors.lastname: Ou
authors.affiliation: Department of Medical Oncology, Chinese People's Liberation Army 476th Hospital, Fujian 350002, China.
authors.forename: Shangxiang
authors.initials: S
authors.lastname: He
authors.affiliation: Department of Medical Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzong Clinical College of Fujian Medical University, Fujian 350025, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Medical Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzong Clinical College of Fujian Medical University, Fujian 350025, China.
authors.forename: Xuenong
authors.initials: X
authors.lastname: Ouyang
mesh_terms: D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins / Q000378:metabolism*; D016019:Survival Analysis
chemical_list: D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; C077591:S100A4 protein, human