title: Pseudomonas aeruginosa Endophthalmitis: Clinical Outcomes and Antibiotic Susceptibilities.
abstract: OBJECTIVE
  To report the clinical characteristics, antibiotic susceptibilities, and visual outcomes for eyes with endophthalmitis caused by Pseudomonas aeruginosa.
  
  
  METHODS
  In this retrospective, non-comparative case series, medical records of eyes with culture-proven Pseudomonas aeruginosa endophthalmitis, who were treated from April 2005 to April 2015 at a referral center in Tehran were reviewed. Clinical features, antibiotic susceptibilities, and visual outcomes were assessed.
  
  
  RESULTS
  In total, 20 eyes of 19 patients were identified. The clinical settings included cataract surgery (85%), pars plana vitrectomy (5%), endogenous source (5%), and intravitreal bevacizumab injection (5%). Presenting visual acuity ranged from 20/120 to no light perception. Pars plana vitrectomy with intravitreal antibiotic injection was performed as the initial treatment in 16 eyes (80%). The organisms were sensitive to ciprofloxacin and imipenem in 100%; amikacin in 88.3%; ceftazidime in 83.4%; and tobramycin in 83.4% of isolates tested. Final visual acuity was hand motions or worse in 18 eyes (90%). Evisceration was performed in five eyes (20%).
  
  
  CONCLUSIONS
  Susceptibility to ciprofloxacin and imipenem was found in all isolates tested. Despite appropriate treatment, visual and anatomic outcomes were generally poor.
authors.affiliation: a Eye Research Center, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.|b Doheny Eye Institute , University of California Los Angeles , Los Angeles , California, USA.
authors.forename: Khalil Ghasemi
authors.initials: KG
authors.lastname: Falavarjani
authors.affiliation: a Eye Research Center, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Sayyed Amirpooya
authors.initials: SA
authors.lastname: Alemzadeh
authors.affiliation: a Eye Research Center, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Habibi
authors.affiliation: a Eye Research Center, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Hadavandkhani
authors.affiliation: a Eye Research Center, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Sareh
authors.initials: S
authors.lastname: Askari
authors.affiliation: a Eye Research Center, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Pourhabibi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002387:Cataract Extraction; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification*; D012189:Retrospective Studies; D014792:Visual Acuity; D014821:Vitrectomy; D014822:Vitreous Body / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotics; Pseudomonas aeruginosa; endophthalmitis