title: Comparison of myelin water fraction values in periventricular white matter lesions between multiple sclerosis and neuromyelitis optica spectrum disorder.
abstract: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory autoimmune diseases of the central nervous system. We hypothesized that the degree of demyelination within lesions in MS and NMOSD would differ as the pathophysiology of the two diseases do. We used myelin water imaging to compare the myelin water fraction (MWF) in 106 periventricular white matter (PVWM) lesions in 27 MS patients and 51 PVWM lesions in 20 NMOSD patients. The MWF was significantly reduced in the MS compared with the NMOSD lesions, suggesting that myelin loss was more severe in MS than in NMOSD.
authors.affiliation: Department of Neurology, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: In Hye
authors.initials: IH
authors.lastname: Jeong
authors.affiliation: Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea.
authors.forename: Joon Yul
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Department of Neurology, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Su-Hyun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Neurology, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Hyun
authors.affiliation: Department of Neurology, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: AeRan
authors.initials: A
authors.lastname: Joung
authors.affiliation: Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea.
authors.forename: Jongho
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Neurology, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea hojinkim@ncc.re.kr.
authors.forename: Ho Jin
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging / Q000473:pathology*; D009186:Myelin Sheath / Q000473:pathology*; D009471:Neuromyelitis Optica / Q000000981:diagnostic imaging / Q000473:pathology*; D014867:Water / Q000378:metabolism; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D014867:Water
keywords: Myelin water imaging; demyelination; multiple sclerosis; neuromyelitis optica spectrum disorder