title: In vitro studies on anti-obesity activity of Korean Memilmuk through AMPK activation.
abstract: The anti-obesity effect of Korean traditional food, Memilmuk, was examined through inhibition of differentiation of 3T3-L1 preadipocytes by buckwheat flour extract. Oil-Red O staining showed that lipid accumulation in adipocytes was reduced upon adding buckwheat flour extract, indicating effective inhibition of adipocyte differentiation. Buckwheat flour extract also inhibited the expression of adipogenic transcription factor, peroxisome proliferator-activated receptor γ (PPARγ), and AMP-activated protein kinase (AMPK), an intracellular regulator of energy balance. Overall, the anti-obesity effect of Korean Memilmuk might be mediated through down-regulation of PPARγ expression via AMPK activation by buckwheat flour.
authors.forename: Gil-Sun
authors.initials: GS
authors.lastname: Park
authors.forename: Yu-Mi
authors.initials: YM
authors.lastname: Jeon
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Kim
authors.forename: Sang-Kyu
authors.initials: SK
authors.lastname: Park
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Lee
mesh_terms: D041721:3T3-L1 Cells; D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D017667:Adipocytes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D000818:Animals; D002470:Cell Survival; D019612:Fagopyrum / Q000737:chemistry*; D055951:Functional Food; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D051379:Mice; D009765:Obesity / Q000188:drug therapy*; D056910:Republic of Korea
chemical_list: D055372:AMP-Activated Protein Kinases