title: Effect of Gastric Bypass on Bone Mineral Density, Parathyroid Hormone and Vitamin D: 5 Years Follow-up.
abstract: BACKGROUND
  The aim of the present study was to see if there are longitudinal changes in bone mineral density (BMD), vitamin D or parathyroid hormone (PTH) in females 5 years after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB).
  
  
  METHODS
  Thirty-two women with mean age 41.6 ± 9.3 years and mean body mass index (BMI) 44.5 ± 4.6 kg/m(2) were included. Preoperatively, 2 and 5 years postoperatively, BMD, weight, height, S-calcium, S-albumin, S-creatinine, S-25(OH)-vitamin D and fP-PTH were measured.
  
  
  RESULTS
  The mean decrease in BMI between baseline and 5 years after surgery was 29.4%. BMD of the spine and femur measured as z- and t-scores, showed a linear, statistically significant declining trend over the years. The fall in BMD of the spine and femoral neck between baseline and 5 years after surgery was 19 and 25%, respectively. The mean fP-PTH showed a significant increase over the study period (20.2 μg/L increase, 95% CI:-31.99 to -8.41). S-calcium, both free and corrected for albumin, showed a decrease between baseline and 5 years after surgery. Eight patients developed osteopenia and one osteoporosis after a 5-year follow-up.
  
  
  CONCLUSIONS
  LRYGB is an efficient method for sustained long-term body weight loss. There is, however, a concomitant decrease in BMD and S-calcium, and an increase in fP-PTH.
authors.affiliation: Lindesberg Hospital, Orebro, Sweden. mustafase@hotmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Raoof
authors.affiliation: Lindesberg Hospital, Orebro, Sweden.
authors.forename: Ingmar
authors.initials: I
authors.lastname: Näslund
authors.affiliation: Lindesberg Hospital, Orebro, Sweden.
authors.forename: Eva
authors.initials: E
authors.lastname: Rask
authors.affiliation: Lindesberg Hospital, Orebro, Sweden.
authors.forename: Eva
authors.initials: E
authors.lastname: Szabo
mesh_terms: D000368:Aged; D015519:Bone Density / Q000502:physiology*; D002118:Calcium / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass; D006801:Humans; D010535:Laparoscopy; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000601:surgery*; D010281:Parathyroid Hormone / Q000097:blood*; D011184:Postoperative Period; D014807:Vitamin D / Q000097:blood*
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D002118:Calcium
keywords: BMI; Bone mineral density; Gastric bypass; Obesity; Parathyroid hormone; Vitamin D