title: Cocrystals and alloys of nitazoxanide: enhanced pharmacokinetics.
abstract: Two isomorphous cocrystals of nitazoxanide (NTZ) with p-aminosalicylic acid (PASA) and p-aminobenzoic acid (PABA) as well as their alloys were prepared by slurry and grinding techniques. The cocrystals exhibit faster dissolution rates and higher pharmacokinetic properties compared to the reference drug, and surprisingly the cocrystal alloy NTZ-PABA : NTZ-PASA (0.75 : 0.25) exhibited 4 fold higher bioavailability of NTZ in Sprague Dawley rats. This study opens the opportunity for cocrystal alloys as improved medicines.
authors.affiliation: School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli Central University P.O., Hyderabad 500046, India.
authors.forename: Kuthuru
authors.initials: K
authors.lastname: Suresh
authors.affiliation: Technology Business Incubator, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli Central University P.O., Hyderabad 500 046, India. ashwini.nangia@gmail.com.
authors.forename: M K Chaitanya
authors.initials: MK
authors.lastname: Mannava
authors.affiliation: School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli Central University P.O., Hyderabad 500046, India and Technology Business Incubator, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli Central University P.O., Hyderabad 500 046, India. ashwini.nangia@gmail.com.
authors.forename: Ashwini
authors.initials: A
authors.lastname: Nangia
mesh_terms: D000497:Alloys / Q000737:chemistry*; D000818:Animals; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D018360:Crystallography, X-Ray; D009574:Nitro Compounds; D051381:Rats; D017207:Rats, Sprague-Dawley; D013844:Thiazoles / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D000497:Alloys; D009574:Nitro Compounds; D013844:Thiazoles; C041747:nitazoxanide