title: Antibacterial and anti-inflammatory drug delivery properties on cotton fabric using betamethasone-loaded mesoporous silica particles stabilized with chitosan and silicone softener.
abstract: In this study, mesoporous silica particles with a hexagonal structure (SBA-15) were synthesized and modified with (3-aminopropyl) triethoxysilane, and used as a carrier for anti-inflammatory drug, betamethasone sodium phosphate. Drug-loaded silica particles were grafted on the cotton fabric surface using chitosan and polysiloxane reactive softener as a soft and safe fixing agent to develop an antibacterial cotton fabric with drug delivery properties. Cytometry assays revealed that synthesized silica have no cytotoxicity against human peripheral blood mononuclear cells. Accordingly, the produced drug-loaded nanostructures can be applied via different routes, such as wound dressing. Drug delivery profile of the treated fabrics were investigated and compared. The drug release rate followed the conventional Higuchi model. The treated cotton fabrics were tested and evaluated using scanning electron microscope images, bending length, air permeability, washing durability and anti-bacterial properties. It was found that the chitosan-/softener-treated fabrics compounded with drug-loaded silica particles have a good drug delivery performance and exhibited a powerful antibacterial activity against both Escherichia coli and Staphylococcus aureus even after five washing cycles. The produced antibacterial cotton fabric with drug delivery properties could be proposed as a suitable material for many medical and hygienic applications.
authors.affiliation: a Department of Textile Engineering, Functional Fibrous Structures & Environmental Enhancement (FFSEE) , Amirkabir University of Technology (Tehran Polytechnic) , Tehran , Iran , and.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Hashemikia
authors.affiliation: a Department of Textile Engineering, Functional Fibrous Structures & Environmental Enhancement (FFSEE) , Amirkabir University of Technology (Tehran Polytechnic) , Tehran , Iran , and.
authors.forename: Nahid
authors.initials: N
authors.lastname: Hemmatinejad
authors.affiliation: b Chemistry Department, University of Zanjan , Zanjan , Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Ahmadi
authors.affiliation: a Department of Textile Engineering, Functional Fibrous Structures & Environmental Enhancement (FFSEE) , Amirkabir University of Technology (Tehran Polytechnic) , Tehran , Iran , and.
authors.forename: Majid
authors.initials: M
authors.lastname: Montazer
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D001623:Betamethasone / Q000031:analogs & derivatives / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D032561:Cotton Fiber; D016503:Drug Delivery Systems / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D007963:Leukocytes, Mononuclear; D053758:Nanoparticles / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D012828:Silicones / Q000737:chemistry*; D012833:Siloxanes / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; C509969:SBA-15; D012828:Silicones; D012833:Siloxanes; D012822:Silicon Dioxide; C028994:betamethasone sodium phosphate; D048271:Chitosan; D001623:Betamethasone
keywords: Antibacterial cotton; chitosan; drug delivery; mesoporous silica; silicone softener