title: Traumatic iridial extrusion mimicking a conjunctival melanocytic neoplasm.
abstract: Conjunctival melanoma is a rare malignant tumour of the eye. Its diagnosis represents a challenge for general pathologists due to low exposure to ocular biopsies and a broad differential diagnosis. In addition, conjunctival samples are often small and are associated with a high frequency of artefacts due to their processing. Here, we present the first case to date of a traumatic iridial extrusion masquerading as a conjunctival melanocytic neoplasm. An 83-year-old Asian man presented with a conjunctival-pigmented nodule surrounded by an area of diffuse pigmentation. Histopathology revealed in the nodule a well-demarcated lesion composed of spindle shaped melanocytes with thick-walled blood vessels. At higher magnification, the blood vessels were composed of thick walls with collagen fibres in an onion-skin-like arrangement. The histological findings were consistent with extruded iridial tissue. The map biopsies of the flat, pigmented lesion showed melanocytic cell proliferation with dendritic processes restricted to the lamina propria without any epithelial involvement, consistent with ocular melanocytosis. The diagnosis of conjunctival melanocytic lesions is challenging, and non-neoplastic conditions should always be included in the differential diagnosis. Pathologists should correlate clinicopathological findings and be familiar with the normal histology in order to achieve the correct diagnosis.
authors.affiliation: Department of Pathology, Henry C Witelson Ocular Pathology Laboratory, McGill University, 1001 Boul Decarie, Montreal H4A 3J1, Canada; Department of Pathology, School of Medicine, Pontificia Universidad Catolica de Chile, Marcoleta 377, Santiago 8330024, Chile.
authors.forename: Pablo
authors.initials: P
authors.lastname: Zoroquiain
authors.affiliation: Faculdade de Ciências Médicas e da Saúde de Juiz de Fora, Suprema, Alameda Salvaterra, 200 - Salvaterra, Juiz de Fora - MG 36033-003, Brazil.
authors.forename: Maria Sb
authors.initials: MS
authors.lastname: Ganimi
authors.affiliation: Department of Pathology, Henry C Witelson Ocular Pathology Laboratory, McGill University, 1001 Boul Decarie, Montreal H4A 3J1, Canada.
authors.forename: Sarah
authors.initials: S
authors.lastname: Alghamdi
authors.affiliation: Department of Pathology, Henry C Witelson Ocular Pathology Laboratory, McGill University, 1001 Boul Decarie, Montreal H4A 3J1, Canada.
authors.forename: Julia V
authors.initials: JV
authors.lastname: Burnier
authors.affiliation: Department of Pathology, Henry C Witelson Ocular Pathology Laboratory, McGill University, 1001 Boul Decarie, Montreal H4A 3J1, Canada; Department of Ophthalmology, College of Medicine, King Saud University, PO Box 245, Riyadh 11411, Saudi Arabia.
authors.forename: Sultan S
authors.initials: SS
authors.lastname: Aldrees
authors.affiliation: Department of Pathology, Henry C Witelson Ocular Pathology Laboratory, McGill University, 1001 Boul Decarie, Montreal H4A 3J1, Canada; Department of Ophthalmology, McGill University, 5252 Boul de Maisonneuve ouest, Montreal H4A 3S5, Canada.
authors.forename: Miguel N
authors.initials: MN
authors.lastname: Burnier
keywords: conjunctival melanoma; iridial extrusion; ocular melanosis