title: Executive dysfunction in patients with chronic primary insomnia treated with clonazepam.
abstract: Clonazepam (CNZ) is a drug used for insomnia treatment. Our objective was to search CNZ effects on executive functions (EF) in patients with chronic primary insomnia (CPI)-CNZ treated. Ninety participants were studied divided into three groups: a group of patients with CPI only (n = 30), a group of patients with CPI-CNZ treated (n = 30) and a healthy control drug-free subjects group (n = 30). EF were examined by means of E-Prime and by the Tower of London tests. Data of the EF were compared between groups, and correlation calculations between EF and CNZ dose were performed. Patients with CPI-CNZ treated showed more deleterious effects on EF (attention, inhibition, working memory, planning, cognitive flexibility, and monitoring) than patients with CPI only. Attention and cognitive flexibility correlated with CNZ dose. In conclusion, CNZ treatment was associated with deficits in some EF in patients with CPI-CNZ treated compared to CPI only and controls. We found a dose dependency between CNZ and some EF deficits.
authors.affiliation: 1 School of Medicine, National University of Mexico-Campus Zaragoza , Mexico City, Mexico.
authors.forename: Noé
authors.initials: N
authors.lastname: Contreras-González
authors.forename: Bernarda
authors.initials: B
authors.lastname: Téllez-Alanís
authors.forename: Reyes
authors.initials: R
authors.lastname: Haro
authors.forename: Ulises
authors.initials: U
authors.lastname: Jiménez-Correa
authors.forename: Adrián
authors.initials: A
authors.lastname: Poblano
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001288:Attention / Q000187:drug effects; D002908:Chronic Disease; D002998:Clonazepam / Q000009:adverse effects*; D003072:Cognition Disorders / Q000139:chemically induced*; D056344:Executive Function / Q000187:drug effects*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D008875:Middle Aged; D009483:Neuropsychological Tests; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D002998:Clonazepam
keywords: Chronic primary insomnia; Clonazepam; Executive functions; Insomnia