title: Sesquiterpenoids from Chinese Agarwood Induced by Artificial Holing.
abstract: Two new sesquiterpenoids, 3-oxo-7-hydroxylholosericin A (1) and 1,5;8,12-diepoxy-guaia-12-one (2), together with seven known sesquiterpenoids 3-9, were isolated from Chinese agarwood induced by artificial holing originating from Aquilaria sinensis (Lour.) Gilg. Their structures were identified by spectroscopic techniques (UV, IR, 1D and 2D NMR) and MS analyses. The absolute configuration of compound 1 was determined by comparison of its measured CD curve with that of calculated data for 1 and ent-1. The NMR data of 3 were reported in this study for the first time. Compounds 1, 2, 4-6, together with the EtOAc extract showed moderate inhibitory activities against acetylcholinesterase, and compounds 4-6, 8 exhibited antibacterial activities against Staphylococcus aureus or Ralstonia solanacearum.
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. liwei@itbb.org.cn.|Hainan Engineering Research Center of Agarwood, Haikou 571101, Hainan, China. liwei@itbb.org.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. lg8goelia@sina.cn.
authors.forename: Ge
authors.initials: G
authors.lastname: Liao
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. dongwenhua@itbb.org.cn.|Hainan Engineering Research Center of Agarwood, Haikou 571101, Hainan, China. dongwenhua@itbb.org.cn.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Dong
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. kongfandong@itbb.org.cn.
authors.forename: Fan-Dong
authors.initials: FD
authors.lastname: Kong
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. wangpei@itbb.org.cn.
authors.forename: Pei
authors.initials: P
authors.lastname: Wang
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. Hao.Wang@uni-duesseldorf.de.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. meiwenli@itbb.org.cn.|Hainan Engineering Research Center of Agarwood, Haikou 571101, Hainan, China. meiwenli@itbb.org.cn.
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. daihaofu@itbb.org.cn.|Hainan Engineering Research Center of Agarwood, Haikou 571101, Hainan, China. daihaofu@itbb.org.cn.
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000032:analysis; D015394:Molecular Structure; D043368:Ralstonia solanacearum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes
keywords: AChE inhibition activity; Aquilaria sinensis; Chinese agarwood induced by artificial holing; antibacterial activity; sesquiterpenoid