title: [Validation of a questionnaire assessing patients' adherence and skill level of management for oral capecitabine treatment].
abstract: BACKGROUND
  There is a plea for the development of tools allowing the screening of fragile patients under oral chemotherapy. Such tools would identify patients with difficulties for being adherent or for having low side effects management skills. The aim of this study is to validate psychometric characteristics of a questionnaire assessing patients' adherence and skill level of management for oral capecitabine treatment.
  
  
  METHODS
  Questionnaire's psychometric validation study. Prospective monocentric cohort. Cases-simulated questionnaire was constructed, according to recommendations, from the results of a socio-anthropological study. Validation phases included: a pre-testing and a field-testing including acceptability, scale reliability and internal consistency were conducted involving experts and patients sample.
  
  
  RESULTS
  Pre-testing excluded 1 item. Acceptability phase included 15 patients, who did not change any of the questions. Reliability and internal consistency were tested with 67 patients. Cancer site did not statistically influence questionnaire answers. No correlation was identify with the analyse performed for the internal consistency testing.
  
  
  CONCLUSIONS
  This questionnaire has shown to be a valid tool for the assessment of the adherence and side effect management skill for patients with capecitabine treatment. It can easily be uses as a screening tool for prescribers. It can also be used as an evaluation tool for a therapeutic education programme in this field.
authors.affiliation: Centre Hygée, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue A.-Raimond, 42270 Saint-Priest-en-Jarez, France; CIC-EC, Inserm 1408, 42000 Saint-Étienne, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Baudot
authors.affiliation: Centre Hygée, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue A.-Raimond, 42270 Saint-Priest-en-Jarez, France; CIC-EC, Inserm 1408, 42000 Saint-Étienne, France; Faculté de médecine Jacques-Lisfranc, 42000 Saint-Étienne, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Oriol
authors.affiliation: Centre Hygée, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue A.-Raimond, 42270 Saint-Priest-en-Jarez, France; CIC-EC, Inserm 1408, 42000 Saint-Étienne, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Tinquaut
authors.affiliation: Centre Hygée, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue A.-Raimond, 42270 Saint-Priest-en-Jarez, France; CIC-EC, Inserm 1408, 42000 Saint-Étienne, France.
authors.forename: Valentin
authors.initials: V
authors.lastname: Moine
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département d'oncologie médicale, 42270 Saint-Priest-en-Jarez, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Moriceau
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département d'oncologie médicale, 42270 Saint-Priest-en-Jarez, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Muron
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département d'oncologie médicale, 42270 Saint-Priest-en-Jarez, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Pacaut
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département d'oncologie médicale, 42270 Saint-Priest-en-Jarez, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Collard
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département d'oncologie médicale, 42270 Saint-Priest-en-Jarez, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Jacquin
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département d'oncologie médicale, 42270 Saint-Priest-en-Jarez, France.
authors.forename: Léa
authors.initials: L
authors.lastname: Saban-Roche
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département d'oncologie médicale, 42270 Saint-Priest-en-Jarez, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Bosacki
authors.affiliation: Centre Hygée, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue A.-Raimond, 42270 Saint-Priest-en-Jarez, France; CIC-EC, Inserm 1408, 42000 Saint-Étienne, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Regnier-Denois
authors.affiliation: Centre Hygée, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue A.-Raimond, 42270 Saint-Priest-en-Jarez, France; CIC-EC, Inserm 1408, 42000 Saint-Étienne, France; Faculté de médecine Jacques-Lisfranc, 42000 Saint-Étienne, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Chauvin
authors.affiliation: Centre Hygée, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue A.-Raimond, 42270 Saint-Priest-en-Jarez, France; CIC-EC, Inserm 1408, 42000 Saint-Étienne, France. Electronic address: Aurelie.bourmaud@icloire.fr.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Bourmaud
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000523:psychology; D000069287:Capecitabine / Q000008:administration & dosage / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000523:psychology; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D011446:Prospective Studies; D011594:Psychometrics; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires
chemical_list: D000964:Antimetabolites, Antineoplastic; D000069287:Capecitabine
keywords: Adherence; Adhérence; Adverse events; Capecitabine; Capécitabine; Chimiothérapies orales; Effets secondaires; Oral chemotherapy; Patient education; Questionnaire psychometric validity; Validation de questionnaire; Éducation thérapeutique