title: Radio(chemo)therapy in locally advanced nonsmall cell lung cancer.
abstract: Definitive radiochemotherapy is the standard treatment for many patients with locally advanced nonsmall cell lung cancer (NSCLC). Treatment outcomes have improved over the last decades. Several treatment regimens have been shown effective and safe. This review summarises the results of significant studies between 1996 and 2015 on concomitant and sequential radiochemotherapy regimens and radiation dose per fraction. Beside therapy regimens, optimised radiotherapy planning is indispensable to improve outcome and minimise radiation-induced toxicity. An insight into the rationale of radiotherapy planning for stage III NSCLC is also provided.
authors.affiliation: Dept of Radiation Oncology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Glatzer
authors.affiliation: Dept of Radiation Oncology, University Hospital Bern, Bern, Switzerland.
authors.forename: Olgun
authors.initials: O
authors.lastname: Elicin
authors.affiliation: Dept of Radiation Oncology, Campus Bio-Medico University, Rome, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Ramella
authors.affiliation: Dept of Radiation Oncology, University Medical Center Freiburg, Freiburg, Germany German Cancer Consortium (DKTK), Heidelberg, Germany.
authors.forename: Ursula
authors.initials: U
authors.lastname: Nestle
authors.affiliation: Dept of Radiation Oncology, Kantonsspital St. Gallen, St. Gallen, Switzerland paul.putora@kssg.ch.
authors.forename: Paul Martin
authors.initials: PM
authors.lastname: Putora
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy / Q000009:adverse effects; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D011829:Radiation Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D016896:Treatment Outcome