title: Cellular senescence impact on immune cell fate and function.
abstract: Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent findings on the role of cellular senescence in immune cell fate decisions in macrophage polarization, natural killer cell phenotype, and following T-lymphocyte activation. We also introduce the involvement of the onset of cellular senescence in some immune responses including T-helper lymphocyte-dependent tissue homeostatic functions and T-regulatory cell-dependent suppressive mechanisms. Altogether, these data propose that cellular senescence plays a wide-reaching role as a homeostatic orchestrator.
authors.affiliation: INSERM, U1183, IRMB, Montpellier Cedex, France.|University of Montpellier, Montpellier, France.|CHRU de Montpellier, IRMB, Montpellier Cedex, France.
authors.forename: Rita
authors.initials: R
authors.lastname: Vicente
authors.affiliation: INSERM, U1183, IRMB, Montpellier Cedex, France.|University of Montpellier, Montpellier, France.|CHRU de Montpellier, IRMB, Montpellier Cedex, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Mausset-Bonnefont
authors.affiliation: INSERM, U1183, IRMB, Montpellier Cedex, France.|University of Montpellier, Montpellier, France.|CHRU de Montpellier, IRMB, Montpellier Cedex, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Jorgensen
authors.affiliation: INSERM, U1183, IRMB, Montpellier Cedex, France.|University of Montpellier, Montpellier, France.|CHRU de Montpellier, IRMB, Montpellier Cedex, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Louis-Plence
authors.affiliation: INSERM, U1183, IRMB, Montpellier Cedex, France.|University of Montpellier, Montpellier, France.|CHRU de Montpellier, IRMB, Montpellier Cedex, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Brondello
mesh_terms: D019070:Cell Lineage; D016922:Cellular Senescence; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007109:Immunity; D008214:Lymphocytes / Q000166:cytology*
keywords: cellular senescence; chronic and autoimmune diseases; immune cells; tissue homeostasis