title: Decreased levels of RGS4 in the paraventricular nucleus facilitate GABAergic inhibition during the acute stress response.
abstract: A healthy acute stress response requires both rapid increase and rapid clearance of blood corticosteroids. We previously showed that regulators of G-protein signaling 4 (RGS4), which decreases in the paraventricular nucleus (PVN) during acute stress, forms a complex with the GABAB receptor. In the present study, we show that this decrease in RGS4 levels in the PVN during an acute stress response facilitates the return of blood corticosteroids to basal levels. Moreover, the effect of RGS4 decrease is attenuated by a GABAB receptor antagonist. These results suggest that RGS4 in the PVN regulates blood corticosteroid-related GABAB receptor signaling during the acute stress response.
authors.affiliation: Department of Anatomy and Convergence Medical Science, Bio Anti-aging Medical Research Center, Institute of Health Sciences, Gyeongsang National University Medical School, Jinju, 52727, Republic of Korea.
authors.forename: Soonwoong
authors.initials: S
authors.lastname: Jung
authors.affiliation: Department of Anatomy and Convergence Medical Science, Bio Anti-aging Medical Research Center, Institute of Health Sciences, Gyeongsang National University Medical School, Jinju, 52727, Republic of Korea.
authors.forename: Hyeonwi
authors.initials: H
authors.lastname: Son
authors.affiliation: Department of Anatomy and Convergence Medical Science, Bio Anti-aging Medical Research Center, Institute of Health Sciences, Gyeongsang National University Medical School, Jinju, 52727, Republic of Korea.
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Anatomy and Convergence Medical Science, Bio Anti-aging Medical Research Center, Institute of Health Sciences, Gyeongsang National University Medical School, Jinju, 52727, Republic of Korea.
authors.forename: Gu Seob
authors.initials: GS
authors.lastname: Roh
authors.affiliation: Department of Anatomy and Convergence Medical Science, Bio Anti-aging Medical Research Center, Institute of Health Sciences, Gyeongsang National University Medical School, Jinju, 52727, Republic of Korea.
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kang
authors.affiliation: Department of Anatomy and Convergence Medical Science, Bio Anti-aging Medical Research Center, Institute of Health Sciences, Gyeongsang National University Medical School, Jinju, 52727, Republic of Korea.
authors.forename: Gyeong Jae
authors.initials: GJ
authors.lastname: Cho
authors.affiliation: Department of Anatomy and Convergence Medical Science, Bio Anti-aging Medical Research Center, Institute of Health Sciences, Gyeongsang National University Medical School, Jinju, 52727, Republic of Korea.
authors.forename: Wan Sung
authors.initials: WS
authors.lastname: Choi
authors.affiliation: Department of Anatomy and Convergence Medical Science, Bio Anti-aging Medical Research Center, Institute of Health Sciences, Gyeongsang National University Medical School, Jinju, 52727, Republic of Korea. Electronic address: kimhj@gnu.ac.kr.
authors.forename: Hyun Joon
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood; D058788:GABA-B Receptor Antagonists / Q000494:pharmacology; D055785:Gene Knockdown Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism*; D020710:RGS Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics; D018080:Receptors, GABA-B / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D013312:Stress, Physiological
chemical_list: D058788:GABA-B Receptor Antagonists; D009943:Organophosphorus Compounds; D020710:RGS Proteins; D034741:RNA, Small Interfering; D018080:Receptors, GABA-B; C107353:CGP 54626; C098799:RGS4 protein; D003345:Corticosterone
keywords: Corticosterone; GABA(B) receptor; PVN; RGS4; shRNA