title: Tau: The Center of a Signaling Nexus in Alzheimer's Disease.
abstract: Tau is a microtubule-associated protein whose misfolding, hyper-phosphorylation, loss of normal function and toxic gain of function are linked to several neurodegenerative disorders, including Alzheimer's disease (AD). This review discusses the role of tau in amyloid-β (Aβ) induced toxicity in AD. The consequences of tau dysfunction, starting from the axon and concluding at somadendritic compartments, will be highlighted.
authors.affiliation: Department of Biology, University of Virginia Charlottesville, VA, USA.
authors.forename: Shahzad S
authors.initials: SS
authors.lastname: Khan
authors.affiliation: Department of Biology, University of Virginia Charlottesville, VA, USA.
authors.forename: George S
authors.initials: GS
authors.lastname: Bloom
keywords: Alzheimer's disease (AD); Amyloid-β oligomers (AβOs); neurofibrillary tangles (NFTs); synaptic dysfunction; tau phosphorylation