title: Dosimetric comparison between step-shoot intensity-modulated radiotherapy and volumetric-modulated arc therapy for upper thoracic and cervical esophageal carcinoma.
abstract: To compare and analyze the dosimetric characteristics of volumetric modulated arc therapy (VMAT) vs step-shoot intensity-modulated radiation therapy (sIMRT) for upper thoracic and cervical esophageal carcinoma. Single-arc VMAT (VMAT1), dual-arc VMAT (VMAT2), and 7-field sIMRT plans were designed for 30 patients with upper thoracic or cervical esophageal carcinoma. Planning target volume (PTV) was prescribed to 50.4Gy in 28 fractions, and PTV1 was prescribed to 60Gy in 28 fractions. The parameters evaluated included dose homogeneity and conformality, dose to organs at risk (OARs), and delivery efficiency. (1) In comparison to sIMRT, VMAT provided a systematic improvement in PTV1 coverage. The homogeneity index of VMAT1 was better than that of VMAT2. There were no significant differences among sIMRT, VMAT1, and VMAT2 in PTV coverage. (2) VMAT1 and VMAT2 reduced the maximum dose of spinal cord as compared with sIMRT (p < 0.05). The rest dose-volume characteristics of OARs were similar. (3) Monitor units of VMAT2 and VMAT1 were more than sIMRT. However, the treatment time of VMAT1, VMAT2, and sIMRT was (2.0 ± 0.2), (2.8 ± 0.3), and (9.8 ± 0.8) minutes, respectively. VMAT1 was the fastest, and the difference was statistically significant. In the treatment of upper thoracic and cervical esophageal carcinoma by the AXESSE linac, compared with 7-field sIMRT, VMAT showed better PTV1 coverage and superior spinal cord sparing. Single-arc VMAT had similar target volume coverage and the sparing of OAR to dual-arc VMAT, with shortest treatment time and highest treatment efficiency in the 3 kinds of plans.
authors.affiliation: Department of Radiation Oncology, The First People׳s Hospital of Changzhou, Changzhou, Jiangsu, China.
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.affiliation: Department of Radiation Oncology, The First People׳s Hospital of Changzhou, Changzhou, Jiangsu, China.
authors.forename: Qilin
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, The First People׳s Hospital of Changzhou, Changzhou, Jiangsu, China.
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Ning
authors.affiliation: Department of Radiation Oncology, The First People׳s Hospital of Changzhou, Changzhou, Jiangsu, China.
authors.forename: Wendong
authors.initials: W
authors.lastname: Gu
authors.affiliation: Department of Radiation Oncology, The First People׳s Hospital of Changzhou, Changzhou, Jiangsu, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Radiation Oncology, The First People׳s Hospital of Changzhou, Changzhou, Jiangsu, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Mu
authors.affiliation: Department of Radiation Oncology, The First People׳s Hospital of Changzhou, Changzhou, Jiangsu, China. Electronic address: hongleipei@126.com.
authors.forename: Honglei
authors.initials: H
authors.lastname: Pei
mesh_terms: D004938:Esophageal Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D058958:Organs at Risk; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*
keywords: Dosimetry; Step-shoot intensity-modulated radiation therapy; Upper thoracic and cervical esophageal carcinoma; Volumetric-modulated arc therapy