title: Curcumin and Health.
abstract: Nowadays, there are some molecules that have shown over the years a high capacity to act against relevant pathologies such as cardiovascular disease, neurodegenerative disorders or cancer. This article provides a brief review about the origin, bioavailability and new research on curcumin and synthetized derivatives. It examines the beneficial effects on health, delving into aspects such as cancer, cardiovascular effects, metabolic syndrome, antioxidant capacity, anti-inflammatory properties, and neurological, liver and respiratory disorders. Thanks to all these activities, curcumin is positioned as an interesting nutraceutical. This is the reason why it has been subjected to several modifications in its structure and administration form that have permitted an increase in bioavailability and effectiveness against different diseases, decreasing the mortality and morbidity associated to these pathologies.
authors.affiliation: Departamento de Bioquímica y Biología Molecular II, Facultad de Farmacia, Campus Universitario de Cartuja, Universidad de Granada, 18071 Granada, Spain. mpulido@ugr.es.|Instituto de Nutrición y Tecnología de los Alimentos José Mataix Verdú, Centro de Investigaciones Biomédicas, Avenida del Conocimiento s/n, Campus Tecnológico y Ciencias de la Salud, Universidad de Granada, Armilla (Granada) 18016, Spain. mpulido@ugr.es.
authors.forename: Mario
authors.initials: M
authors.lastname: Pulido-Moran
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos José Mataix Verdú, Centro de Investigaciones Biomédicas, Avenida del Conocimiento s/n, Campus Tecnológico y Ciencias de la Salud, Universidad de Granada, Armilla (Granada) 18016, Spain. jorgemf@correo.ugr.es.|Departamento de Fisiología, Facultad de Farmacia, Campus Universitario de Cartuja, Universidad de Granada, 18071 Granada, Spain. jorgemf@correo.ugr.es.
authors.forename: Jorge
authors.initials: J
authors.lastname: Moreno-Fernandez
authors.affiliation: Servicio de Anatomía Patológica, Complejo Hospitalario de Jaen, 23007 Jaén, Spain. cesarl.ramirez.sspa@juntadeandalucia.es.
authors.forename: Cesar
authors.initials: C
authors.lastname: Ramirez-Tortosa
authors.affiliation: Departamento de Bioquímica y Biología Molecular II, Facultad de Farmacia, Campus Universitario de Cartuja, Universidad de Granada, 18071 Granada, Spain. mramirez@ugr.es.|Instituto de Nutrición y Tecnología de los Alimentos José Mataix Verdú, Centro de Investigaciones Biomédicas, Avenida del Conocimiento s/n, Campus Tecnológico y Ciencias de la Salud, Universidad de Granada, Armilla (Granada) 18016, Spain. mramirez@ugr.es.
authors.forename: Mcarmen
authors.initials: M
authors.lastname: Ramirez-Tortosa
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D000975:Antioxidants / Q000138:chemical synthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D001682:Biological Availability; D002316:Cardiotonic Agents / Q000138:chemical synthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000138:chemical synthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation; D009369:Neoplasms / Q000188:drug therapy; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D010946:Plants, Medicinal
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D002316:Cardiotonic Agents; D018696:Neuroprotective Agents; D003474:Curcumin
keywords: ROS; anti-inflammatory; antioxidant; bioavailability; cancer; cardiovascular diseases; curcumin; liver disorders; lung diseases; natural compound