title: Asymmetric P-C Bond Formation: Diastereoselective Synthesis of Adjacent P,C-Stereogenic Allylic Phosphorus Compounds.
abstract: A novel catalytic asymmetric P-C bond formation between phosphinates/phosphine oxide and allylic carbonates was developed. This methodology could not only afford a variety of functionalized adjacent P,C-stereogenic phosphorus compounds in high yields with high regio- and diastereoselectivities but also provide an alternative strategy to access enantiomerically enriched (SP )-phosphinates through kinetic resolution.
authors.affiliation: College of Chemistry and Molecular Engineering, Nanjing Tech University, 211816, P. R. China. peizhongxie@njtech.edu.cn.
authors.forename: Peizhong
authors.initials: P
authors.lastname: Xie
authors.affiliation: College of Chemistry and Molecular Engineering, Nanjing Tech University, 211816, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.affiliation: College of Chemistry and Molecular Engineering, Nanjing Tech University, 211816, P. R. China.
authors.forename: Lanlan
authors.initials: L
authors.lastname: Xu
authors.affiliation: College of Chemistry and Molecular Engineering, Nanjing Tech University, 211816, P. R. China. teckpeng@ntu.edu.sg, teckpeng@ntu.edu.sg.|Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore. teckpeng@ntu.edu.sg, teckpeng@ntu.edu.sg.
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh
keywords: 1,3-bisphosphinylpropanes; P-stereogenic compounds; P−C bond formation; kinetic resolution; organocatalysis