title: Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs.
abstract: Over the last decade, the isoxazoline motif has become the intense focus of crop protection and animal health companies in their search for novel pesticides and ectoparasiticides. Herein we report the discovery of sarolaner, a proprietary, optimized-for-animal health use isoxazoline, for once-a-month oral treatment of flea and tick infestation on dogs.
authors.affiliation: Department of Medicinal Chemistry, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Curtis
authors.affiliation: Department of Medicinal Chemistry, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Valerie
authors.initials: V
authors.lastname: Vaillancourt
authors.affiliation: Department of Medicinal Chemistry, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Goodwin
authors.affiliation: Department of Medicinal Chemistry, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Nathan A L
authors.initials: NA
authors.lastname: Chubb
authors.affiliation: Department of Medicinal Chemistry, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: William
authors.initials: W
authors.lastname: Howson
authors.affiliation: Department of Parasitology, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Tom L
authors.initials: TL
authors.lastname: McTier
authors.affiliation: Department of Parasitology, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Aleah
authors.initials: A
authors.lastname: Pullins
authors.affiliation: Department of Parasitology, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Erich W
authors.initials: EW
authors.lastname: Zinser
authors.affiliation: Department of Parasitology, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Patrick F M
authors.initials: PF
authors.lastname: Meeus
authors.affiliation: Department of Parasitology, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Woods
authors.affiliation: Department of Metabolism & Safety, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Hedges
authors.affiliation: Department of Pharmaceutical Sciences, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Tim
authors.initials: T
authors.lastname: Stuk
authors.affiliation: Department of Pharmaceutical Sciences, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Price
authors.affiliation: Department of Pharmaceutical Sciences, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Koch
authors.affiliation: Department of Medicinal Chemistry, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA. Electronic address: sanjay.menon@zoetis.com.
authors.forename: Sanjay R
authors.initials: SR
authors.lastname: Menon
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D058251:Ctenocephalides / Q000187:drug effects; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D058267:Flea Infestations / Q000188:drug therapy / Q000662:veterinary*; D007555:Isoxazoles / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D048508:Rhipicephalus sanguineus / Q000187:drug effects; D005423:Siphonaptera / Q000187:drug effects; D013984:Tick Infestations / Q000188:drug therapy / Q000662:veterinary*; D013987:Ticks / Q000187:drug effects
chemical_list: D000977:Antiparasitic Agents; D007555:Isoxazoles
keywords: Ectoparasiticide; Isoxazoline; Oral flea and tick agent; Sarolaner