title: Organocatalytic Site-Selective Acylation of 10-Deacetylbaccatin III.
abstract: Organocatalytic site-selective diversification of 10-deacetylbaccatin III, a key natural product for the semisynthesis of taxol, has been achieved. Various acyl groups were selectively introduced into the C(10)-OH of 10-deacetylbaccatin III. The C(10)-OH selective acylation was also applied to acylative site-selective dimerization of 10-deacetylbaccatin III to provide the structurally defined dimer.
authors.affiliation: Institute for Chemical Research, Kyoto University.
authors.forename: Masanori
authors.initials: M
authors.lastname: Yanagi
authors.forename: Ryo
authors.initials: R
authors.lastname: Ninomiya
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ueda
authors.forename: Takumi
authors.initials: T
authors.lastname: Furuta
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sunazuka
authors.forename: Takeo
authors.initials: T
authors.lastname: Kawabata
mesh_terms: D015761:4-Aminopyridine / Q000031:analogs & derivatives* / Q000737:chemistry; D000215:Acylation; D002384:Catalysis; D008968:Molecular Conformation; D043823:Taxoids / Q000737:chemistry*
chemical_list: D043823:Taxoids; C042213:10-deacetylbaccatine III; D015761:4-Aminopyridine; C003885:4-dimethylaminopyridine