title: Cu/Fe Catalyzed Intermolecular Oxidative Amination of Benzylic C-H Bonds.
abstract: We report a Cu/Fe co-catalyzed Ritter-type C-H activation/amination reaction that allows efficient and selective intermolecular functionalization of benzylic C-H bonds. This new reaction is featured by simple reaction conditions, readily available reagents and general substrate scope, allowing facile synthesis of biologically interesting nitrogen containing heterocycles. The Cu and Fe salts were found to play distinct roles in this cooperative catalysis.
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, P. R. China.|Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Cong
authors.initials: C
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Shuangxi
authors.initials: S
authors.lastname: Guo
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xiao
authors.affiliation: School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, 201418, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, P. R. China. whe@mail.tsinghua.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: He
keywords: Cu catalysis; C−H activation; C−H amination; Fe catalysis; benzylic