title: [Short-term efficacy and toxicity of Nimotuzumab combined with simultaneous integrated boost intensity-modulated radiotherapy for locally advanced esophageal cancer].
abstract: OBJECTIVE
  To evaluate the short-term efficacy and toxicity of Nimotuzumab combined with simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) in the treatment of locally advanced esophageal carcinoma.
  
  
  METHODS
  Twenty-nine patients with esophageal carcinoma were treated with SIB-IMRT. Planning gross target volume (PGTV) was given at a dose of 60 Gy/2.4 Gy/25 F and planning target volume (PTV) was given at a dose of 50 Gy/2 Gy/25 F. Nimotuzumab was given by intravenous drip at the dose of 200 mg, once a week before radiotherapy. Short-term efficacy and toxicity were evaluated in all patients.
  
  
  RESULTS
  All patients completed the treatment successfully. Fourteen of them achieved a complete response (CR, 48.3%), 13 had a partial response (PR, 44.8%), 1 showed stable disease (SD, 3.6%), and 1 showed progressive disease (PD, 3.6%). The overall response rate (CR+ PR) was 93.1%. Most adverse reactions were radioactive esophagitis, radioactive dermatitis and bone marrow suppression (grade 1-2). Only 1 patient developed a slight skin rash.
  
  
  CONCLUSIONS
  Nimotuzumab combined with SIB-IMRT is a safe and effective modality for locally advanced esophageal cancer. The patient is well tolerated and worthy of further clinical study.
authors.affiliation: Department of Radiation Oncology, Affiliated Hospital of Nantong University, Nantong 226001, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Chen
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xue
authors.forename: Xiaojue
authors.initials: X
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Shi
authors.forename: Jianbo
authors.initials: J
authors.lastname: Ma
authors.forename: Bin
authors.initials: B
authors.lastname: Ji
authors.forename: Buyou
authors.initials: B
authors.lastname: Chen
mesh_terms: D061067:Antibodies, Monoclonal, Humanized; D004938:Esophageal Neoplasms; D004941:Esophagitis; D006801:Humans; D050397:Radiotherapy, Intensity-Modulated; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C501466:nimotuzumab