title: Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics.
abstract: Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide therapeutical benefits. Exosomal products can include miRNA, other genetic products, proteins, and various factors. They are released from cells in a paracrine fashion in order to combat local cellular stress. Because of this, there are vast benefits that medicine can obtain from stem cell-derived exosomes. If exosomes could be extracted from stem cells in an efficient manner and packaged with particular regenerative products, then diseases such as rheumatoid arthritis, osteoarthritis, bone fractures, and other maladies could be treated with cell-free regenerative medicine via exosomes. Many advances must be made to get to this point, and the following review highlights the current advances of stem cell-derived exosomes with particular attention to regenerative medicine in orthopaedics.
authors.affiliation: Department of Orthopedics, Georgia Regents University, Augusta, GA 30912, USA.
authors.forename: John
authors.initials: J
authors.lastname: Burke
authors.affiliation: Department of Pathology, Georgia Regents University, Augusta, GA 30912, USA.
authors.forename: Ravindra
authors.initials: R
authors.lastname: Kolhe
authors.affiliation: Department of Orthopedics, Georgia Regents University, Augusta, GA 30912, USA.
authors.forename: Monte
authors.initials: M
authors.lastname: Hunter
authors.affiliation: Department of Orthopedics, Georgia Regents University, Augusta, GA 30912, USA; Institute of Regenerative and Reparative Medicine, Georgia Regents University, Augusta, GA 30912, USA.
authors.forename: Carlos
authors.initials: C
authors.lastname: Isales
authors.affiliation: Institute of Regenerative and Reparative Medicine, Georgia Regents University, Augusta, GA 30912, USA; Department of Cell Biology and Anatomy, Georgia Regents University, Augusta, GA 30912, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Hamrick
authors.affiliation: Department of Orthopedics, Georgia Regents University, Augusta, GA 30912, USA; Institute of Regenerative and Reparative Medicine, Georgia Regents University, Augusta, GA 30912, USA.
authors.forename: Sadanand
authors.initials: S
authors.lastname: Fulzele