title: Platelets as Biomarkers of Coronary Artery Disease.
abstract: Primary and secondary prevention of cardiovascular disease remain a public health priority. Effective risk stratification of patients is a central requisite for effective preventative care and several scoring systems incorporating biomarkers have been used for prognostication in patients to guide intervention decisions. Thrombosis of atherosclerotic coronary arteries is the main mechanism behind the acute coronary syndromes and since platelets play a pivotal role in the pathogenesis of thrombosis, atherogenesis, and angiogenesis, platelet-derived biomarkers are an attractive concept. This review assesses the potential and the limitations of a range of platelet-based assays as biomarkers for coronary artery disease.
authors.affiliation: Prince of Wales Clinical School, Adult Cancer Program, University of New South Wales, Sydney, Australia.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Pasalic
authors.affiliation: ANZAC Research Institute, Concord, Sydney, Australia.
authors.forename: Samuel S Y
authors.initials: SS
authors.lastname: Wang
authors.affiliation: Prince of Wales Clinical School, Adult Cancer Program, University of New South Wales, Sydney, Australia.
authors.forename: Vivien M Y
authors.initials: VM
authors.lastname: Chen
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood*; D001792:Blood Platelets / Q000502:physiology*; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008955:Models, Cardiovascular; D010976:Platelet Count; D012307:Risk Factors; D013927:Thrombosis / Q000503:physiopathology*
chemical_list: D015415:Biomarkers