title: Imaging findings after methanol intoxication (cohort of 46 patients).
abstract: OBJECTIVE
  Our goal is to demonstrate the variability of imaging findings, primarily in the MRI, in 46 patients who survived acute methanol poisoning. This cohort of patients is the largest such sample group examined by MRI.
  
  
  METHODS
  Patients were examined by means of imaging methods (42 patients by MRI and 4 by CT). All had an identical protocol of MR examination (T2WI, FLAIR, T1WI with or without application of contrast medium and T2WI/FFE, DWI in the transversal plane of the scan, and with focus on the optic nerves in the coronal plane of the scan in T2WI-SPIR).
  
  
  RESULTS
  Imaging methods revealed a positive finding associated with methanol intoxication in 21 patients (46%). These consisted of symmetrical lesions in the putamen--13 patients (28%), haemorrhage--13 cases (28%), deposits in white matter with localization primarily subcortically--4 cases (9%), lesions in the region of the globus pallidus--7 cases (15%) (in 6 cases without combination with the lesions in the putamen), lesions in the brainstem afflicted 6 patients (13%), and lesion in the cerebellum was found in one case. A pathological finding was found only in the patients examined by MRI.
  
  
  CONCLUSIONS
  Almost half of the patients who survived acute methanol poisoning had pathological findings by MRI. The most common finding concerned an affliction of the putamen, which is a predilection area. An interesting finding was the relatively frequent occurrence of selective lesion of the globus pallidus, which is more usually associated with other types of intoxication.
authors.affiliation: MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: Manuela
authors.initials: M
authors.lastname: Vaneckova
authors.affiliation: Department of Occupational Medicine of the First Faculty of Medicine and General University Hospital, Charles University Prague, Czech Republic.
authors.forename: Sergey
authors.initials: S
authors.lastname: Zakharov
authors.affiliation: Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Klempir
authors.affiliation: Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: Evzen
authors.initials: E
authors.lastname: Ruzicka
authors.affiliation: Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Bezdicek
authors.affiliation: Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Brozova
authors.affiliation: Department of Ophthalmology, Charles University in Prague, First Faculty of Medicine and General University Hospital, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Diblik
authors.affiliation: Department of Addictology, Charles University in Prague, First Faculty of Medicine and General University Hospital, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Miovsky
authors.affiliation: Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: Jaroslav Alois
authors.initials: JA
authors.lastname: Hubacek
authors.affiliation: Department of Occupational Medicine of the First Faculty of Medicine and General University Hospital, Charles University Prague, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Urban
authors.affiliation: Department of Occupational Medicine of the First Faculty of Medicine and General University Hospital, Charles University Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Ridzon
authors.affiliation: Department of Occupational Medicine of the First Faculty of Medicine and General University Hospital, Charles University Prague, Czech Republic.
authors.forename: Daniela
authors.initials: D
authors.lastname: Pelclova
authors.affiliation: MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: Andrea
authors.initials: A
authors.lastname: Burgetova
authors.affiliation: MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Masek
authors.affiliation: Department of Occupational Medicine of the First Faculty of Medicine and General University Hospital, Charles University Prague, Czech Republic.
authors.forename: Katerina
authors.initials: K
authors.lastname: Kotikova
authors.affiliation: Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: Kamila
authors.initials: K
authors.lastname: Peterova
authors.affiliation: Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: Irena
authors.initials: I
authors.lastname: Liskova
authors.affiliation: The College of Nursing, o.p. s, Duskova, Prague, Czech Republic.
authors.forename: Lidmila
authors.initials: L
authors.lastname: Hamplova
authors.affiliation: MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Seidl
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D001933:Brain Stem / Q000000981:diagnostic imaging / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D005917:Globus Pallidus / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000432:Methanol / Q000506:poisoning*; D008875:Middle Aged; D011041:Poisoning / Q000150:complications / Q000175:diagnosis*; D011699:Putamen / Q000000981:diagnostic imaging / Q000473:pathology; D020146:Putaminal Hemorrhage / Q000175:diagnosis* / Q000209:etiology; D012997:Solvents / Q000506:poisoning*; D014057:Tomography, X-Ray Computed; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D012997:Solvents; D000432:Methanol