title: The isolation, Characterization and Preclinical Studies of Metal Complex of Thespesia populnea for the Potential Peroxisome Proliferator-activated Receptors-γ Agonist Activity.
abstract: BACKGROUND
  Diabetes mellitus is an international public health problem since ancient days. The condition is predominantly more severe in developing countries like India where, life is more sedentary due to the even changing lifestyles in this fast-paced global scenario. Thespesia populnea is widely used in the ayurvedic system of medicine for treatment of diabetes mellitus in India for years. The aim of this work is to explore the anti-diabetic activity of the isolated compound.
  
  
  METHODS
  The sesquiterpene isolated from hexane fraction of bark of T. populnea modified synthetically then identified by using analytical techniques such as electron paramagnetic resonance spectra for confirmation and the anti-diabetic activity was evaluated by anti-hyperglycemic, hypoglycemic potential.
  
  
  RESULTS
  In the present work, we have studied the anti-hyperglycemic and hypoglycemic activity of the vanadium complex in glucose loaded and normal animals were shown significantly decreased in plasma blood glucose level. The results derived from preclinical studies confirm the potential of new sesquiterpene.
  
  
  CONCLUSIONS
  The findings could provide evidence regarding the anti-diabetic potential of T. populnea by lowering blood glucose level.
  
  
  CONCLUSIONS
  Thespesia populnea is widely used in the ayurvedic system of medicine for treatment of diabetes in India. Present study aimed to explore the anti diabetic potential of isolated compound. Isolation of sesquiterpene from hexane fraction of bark of Thespesia populnea and modified synthetically then authenticated by using analytical techniques such as electron paramagnetic resonance spectra for confirmation. The modified complex was further assessed for its anti diabetic property in glucose loaded rats. Vanadium complex demonstrated significant reduction in plasma blood glucose level in glucose loaded animals. The results derived from preclinical studies confirm the potential of new sesquiterpene. The present findings conclude that anti diabetic potential of Thespesia populnea could be due to lowering blood glucose level by acting on PPAR-γ receptor.
authors.affiliation: Department of Pharmacognosy, Modern College of Pharmacy, Nigdi, India.
authors.forename: Mohini Ashok
authors.initials: MA
authors.lastname: Phanse
authors.affiliation: Department of Pharmacognosy, Maratha Mitramandal College of Pharmacy, Kalewadi, Pune, Maharashtra, India.
authors.forename: Manohar Janardhan
authors.initials: MJ
authors.lastname: Patil
authors.affiliation: Department of Pharmaceutics, Mallareddy Institute of Pharmaceutical Sciences, Hyderabad, Telangana, India.
authors.forename: Konde
authors.initials: K
authors.lastname: Abbulu
keywords: Antihyperglycemic and hypoglycemic activity; Thespesia populnea; diabetes mellitus