title: Acquired-resistance of bevacizumab treatment for radiation brain necrosis: a case report.
abstract: The case study reported on acquired bevacizumab resistance in one patient receiving re-treatment with bevacizumab following radiation brain necrosis progression after bevacizumab was discontinued. This case offers novel and additional insight for bevacizumab treatment. Low-dose bevacizumab is effective for radiation brain necrosis, and radiation brain necrosis may progress after bevacizumab discontinuation, whereas too many cycles of bevacizumab treatment may induce drug-resistance and re-treatment failure following the progression. Therefore, more rational administration for radiation brain necrosis with bevacizumab may include three aspects: short-course treatment, timely discontinuation upon obtaining satisfactory effects (to prevent long-term medication associated resistance) and re-treatment after brain necrosis progression.
authors.affiliation: Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
authors.forename: Hongqing
authors.initials: H
authors.lastname: Zhuang
authors.affiliation: Department of Radiotherapy, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Hebei, China.
authors.forename: Xiangkun
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Department of Chemo-Radiotherapy, Chengde Center Hospital, Second Clinical Medical School of Chengde Medical University, Hebei, China.
authors.forename: Dayong
authors.initials: D
authors.lastname: Sun
authors.affiliation: Department of Radiotherapy, Affiliated Hospital of Hebei University, Hebei, China.
authors.forename: Jianliang
authors.initials: J
authors.lastname: Bian
authors.affiliation: Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Joe Y
authors.initials: JY
authors.lastname: Chang
authors.affiliation: Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
keywords: acquired resistance; bevacizumab; radiation brain necrosis