title: The emerging role of fibroblast growth factor 21 in diabetic nephropathy.
abstract: Diabetic nephropathy (DN), an important cause of end-stage renal diseases, brings about great social and economic burden. Due to the variable pathological changes and clinical course, the prognosis of DN is very difficult to predict. DN is also usually associated with enhanced genomic damage and cellular injury. Fibroblast growth factor 21 (FGF21), a nutritionally regulated hormone secreted mainly by the liver, plays a critical role in metabolism. Administration of FGF21 decreases blood glucose, triglyceride, and cholesterol levels, and improves insulin sensitivity, which is closely associated with the development and progression of glomerular diseases. In addition, FGF21 level was associated with renal function. However, the precise role of FGF21 in DN remains unclear. This review will give a comprehensive understanding of the underlying role of FGF21 and its possible interaction with other molecules in DN.
authors.affiliation: a Department of Pediatrics , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , China and.
authors.forename: Song
authors.initials: S
authors.lastname: Mao
authors.affiliation: b Department of Pediatrics , Nanjing Jinling Hospital , Nanjing , China.
authors.forename: Xianguo
authors.initials: X
authors.lastname: Ren
authors.affiliation: a Department of Pediatrics , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , China and.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
mesh_terms: D001786:Blood Glucose; D002784:Cholesterol / Q000097:blood; D003928:Diabetic Nephropathies / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000627:therapeutic use*; D015894:Genome, Human; D006801:Humans; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D002784:Cholesterol
keywords: Diabetic nephropathy; fibroblast growth factor 21, review; role