title: [Method of multilayer assembly as alternative to antibacterial coverings of medicobiological implants].
abstract: Department of Traumatology and Orthopedics Almaty Kazakh Medical University of Continuing Education; 4. Moscow Regional Research Clinical Institute, Russia Resume: in this report we present the results on the use of the method of layer-by-layer (LbL) for obtaining antimicrobial coatings for biomedical implants. As the substrates were used silicon titanium implants and silicon plate. For the obtaining multilayer coatings on the surfaces of the samples were used as the polycation--chitosan and polyanion--carboxymethylcellulose sodium. On the surface multilayer were deposited antibacterial preparations: Triclosan-2,4,4'trichloro-2' hydroxyphenyl ether, silver ions and iodine. Microbiological studies were conducted on the museum strains: E. coli, Candida and Staf. Preliminary antibacterial studies on these microorganisms showed high activity multilayer coating containing triclosan.
authors.affiliation: Department of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
authors.forename: A K
authors.initials: AK
authors.lastname: Ospanova
authors.affiliation: Kazakh National Medical University. SD Asfendiyarov, Almaty, Kazakhstan.
authors.forename: R A
authors.initials: RA
authors.lastname: Omarova
authors.affiliation: Department of Traumatology and Orthopedics Almaty Kazakh Medical University of Continuing Education.
authors.forename: U A
authors.initials: UA
authors.lastname: Abdurazakov
authors.affiliation: Kazakh National Medical University. SD Asfendiyarov, Almaty, Kazakhstan.
authors.forename: R N
authors.initials: RN
authors.lastname: Zhartybaev
authors.affiliation: Kazakh National Medical University. SD Asfendiyarov, Almaty, Kazakhstan.
authors.forename: M K
authors.initials: MK
authors.lastname: Iskakova
authors.affiliation: Department of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
authors.forename: B E
authors.initials: BE
authors.lastname: Savdenbekova
authors.affiliation: Moscow Regional Research Clinical Institute, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Amkhadova
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D000071228:Polyelectrolytes; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology; D019736:Prostheses and Implants; D012834:Silver / Q000737:chemistry / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects; D014260:Triclosan / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002266:Carboxymethylcellulose Sodium; D048271:Chitosan; D020099:Coated Materials, Biocompatible; D000071228:Polyelectrolytes; D011108:Polymers; D012834:Silver; D014260:Triclosan