title: Imaging of myocardial fatty acid oxidation.
abstract: Myocardial fuel selection is a key feature of the health and function of the heart, with clear links between myocardial function and fuel selection and important impacts of fuel selection on ischemia tolerance. Radiopharmaceuticals provide uniquely valuable tools for in vivo, non-invasive assessment of these aspects of cardiac function and metabolism. Here we review the landscape of imaging probes developed to provide non-invasive assessment of myocardial fatty acid oxidation (MFAO). Also, we review the state of current knowledge that myocardial fatty acid imaging has helped establish of static and dynamic fuel selection that characterizes cardiac and cardiometabolic disease and the interplay between fuel selection and various aspects of cardiac function. This article is part of a Special Issue entitled: Heart Lipid Metabolism edited by G.D. Lopaschuk.
authors.affiliation: Department of Medicine, Indiana University Medical Center, Gatch Hall, Suite 365, 1120 W. Michigan St., Indianapolis, IN 46202-5111, USA. Electronic address: kmather@iu.edu.
authors.forename: Kieren J
authors.initials: KJ
authors.lastname: Mather
authors.affiliation: Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: degrado.timothy@mayo.edu.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: DeGrado
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D021621:Imaging, Three-Dimensional; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D019275:Radiopharmaceuticals / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D019275:Radiopharmaceuticals
keywords: Fatty acid oxidation; Fatty acid uptake; Metabolic imaging; Myocardial metabolism; PET; SPECT