title: Dynamic prediction of the risk of recurrence in patients over 60 years of age with differentiated thyroid carcinoma.
abstract: OBJECTIVE
  The reclassification of the risk according to the response to the initial treatment makes the treatment of differentiated thyroid cancer (DTC) vary in each individual. As the influence of age on this diagnostic strategy is unknown, we have decided to assess it in adults who are over 60 years of age.
  
  
  METHODS
  Ninety patients with DTC above 60 years old were enrolled, with total thyroidectomy plus radioiodine ablation, negative anti-thyroglobulin antibodies, follow-up ≥ 2 years and with clinical and pathological information to classify the risk of recurrence according to ATA (American Thyroid Association) and reclassify based on the response to initial therapy according to MSKCC (Memorial Sloan Kettering Cancer Center). The structural persistence at the end of the follow-up was the gold standard of our analysis.
  
  
  RESULTS
  The structural persistence in ATA low, intermediate and high risk categories was 0, 38, and 100%, respectively. In the intermediate group, none of those with an excellent response to the initial treatment showed structural persistence, whereas 39% of those with an incomplete/indeterminate response showed structural persistence (p < 0.01).
  
  
  CONCLUSIONS
  The re-stratification according to the response to the initial treatment in patients over 60 years of age with an ATA intermediate risk of recurrence allowed for the distinction of disease-free patients at the end of the follow-up from those with structural persistence and a worse clinical progression.
authors.affiliation: Division of Endocrinology, Dr. César Milstein Hospital, Buenos Aires, Argentina.
authors.forename: Yanina Jimena
authors.initials: YJ
authors.lastname: Morosán
authors.affiliation: Division of Endocrinology, Dr. César Milstein Hospital, Buenos Aires, Argentina.
authors.forename: Carina
authors.initials: C
authors.lastname: Parisi
authors.affiliation: Division of Endocrinology, Dr. César Milstein Hospital, Buenos Aires, Argentina.
authors.forename: María Agustina
authors.initials: MA
authors.lastname: Urrutia
authors.affiliation: Division of Endocrinology, Dr. César Milstein Hospital, Buenos Aires, Argentina.
authors.forename: Melanie
authors.initials: M
authors.lastname: Rosmarin
authors.affiliation: Division of Endocrinology, Dr. César Milstein Hospital, Buenos Aires, Argentina.
authors.forename: Marta
authors.initials: M
authors.lastname: Schnitman
authors.affiliation: Division of Surgery, Dr. César Milstein Hospital, Buenos Aires, Argentina.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Serrano
authors.affiliation: Division of Surgery, Dr. César Milstein Hospital, Buenos Aires, Argentina.
authors.forename: Wilfrido
authors.initials: W
authors.lastname: Luciani
authors.affiliation: Division of Endocrinology, Dr. César Milstein Hospital, Buenos Aires, Argentina.
authors.forename: Cristina
authors.initials: C
authors.lastname: Faingold
authors.affiliation: Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Fabián
authors.initials: F
authors.lastname: Pitoia
authors.affiliation: Division of Endocrinology, Dr. César Milstein Hospital, Buenos Aires, Argentina.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Brenta
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology* / Q000628:therapy*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013954:Thyroglobulin / Q000097:blood; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000628:therapy*; D013965:Thyroidectomy; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D013954:Thyroglobulin