title: Fungal skin and soft tissue infections.
abstract: OBJECTIVE
  Cutaneous and subcutaneous mycoses are a source of significant morbidity both in immunocompetent and immunocompromised patients. We here review the latest findings in terms of genetic predisposition, epidemiology, clinical manifestations, and therapeutic strategies in these diseases.
  
  
  RESULTS
  A growing number of fungal skin and soft tissue infections are reported worldwide. In immunocompromised patients, these infections are often associated with disseminated disease. Skin and soft tissue biopsies usually allow mycological identification. Although tissue culture remains the gold standard, molecular biology is increasingly used and sometimes mandatory for accurate diagnosis. Advances in therapeutics have improved outcome and lowered dissemination risk in patients.
  
  
  CONCLUSIONS
  Cutaneous and subcutaneous mycoses are an evolving field. Clinicians all over the world should be aware of the common manifestations of these diseases - infectious diseases - as they are increasingly reported and may lead to or be associated with dissemination.
authors.affiliation: aAssistance Publique-Hôpitaux de Paris, Service de Dermatologie, Hôpital TenonbUniversité Pierre et Marie Curie-Paris VIcINSERM U938, Saint Antoine Research CenterdInstitut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et AntifongiqueseCNRS URA3012fAssistance Publique-Hôpitaux de Paris, Centre d'Infectiologie Necker Pasteur, Hôpital Necker-Enfants maladesgUniversité René Descartes-ParishAssistance Publique-Hôpitaux de Paris, Service de Dermatologie, Hôpital Cochin, Paris, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Guégan
authors.forename: Fanny
authors.initials: F
authors.lastname: Lanternier
authors.forename: Claire
authors.initials: C
authors.lastname: Rouzaud
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dupin
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D003881:Dermatomycoses / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology* / Q000473:pathology; D005658:Fungi / Q000302:isolation & purification*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008828:Microbiological Techniques / Q000379:methods; D018461:Soft Tissue Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology* / Q000473:pathology
chemical_list: D000935:Antifungal Agents