title: Extended-Synaptotagmins (E-Syts); the extended story.
abstract: The Extended-Synaptotagmin (E-Syt) membrane proteins were only recently discovered, but have already been implicated in a range of interrelated cellular functions, including calcium and receptor signaling, and membrane lipid transport. However, despite their evolutionary conservation and detailed studies of their molecular actions, we still have little idea of how and when these proteins are required in cellular and organism physiology. Here we review our present understanding of the E-Syts and discuss the molecular functions and in vivo requirements for these proteins.
authors.affiliation: Laboratory of Growth and Development, St-Patrick Research Group in Basic Oncology, Cancer Division of the Québec University Hospital Research Centre, Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Laval University, Edifice St Patrick, 9 rue McMahon, Québec, QC G1R 3S3, Canada.
authors.forename: Chelsea
authors.initials: C
authors.lastname: Herdman
authors.affiliation: Laboratory of Growth and Development, St-Patrick Research Group in Basic Oncology, Cancer Division of the Québec University Hospital Research Centre, Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Laval University, Edifice St Patrick, 9 rue McMahon, Québec, QC G1R 3S3, Canada. Electronic address: Tom.Moss@crhdq.ulaval.ca.
authors.forename: Tom
authors.initials: T
authors.lastname: Moss
mesh_terms: D000818:Animals; D006801:Humans; D011487:Protein Conformation; D015398:Signal Transduction; D050857:Synaptotagmins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D050857:Synaptotagmins
keywords: Calcium Signaling​; ER-PM Tethering​; EndoplasmicReticulum (ER) - Plasma Membrane(PM) Junctions; Extended Synaptotagmin (E-Syt,ESYT)​; FGF Signaling​; Phospholipid Metabolism​