title: Does injection of plasma rich in growth factors after temporomandibular joint arthroscopy improve outcomes in patients with Wilkes stage IV internal derangement? A randomized prospective clinical study.
abstract: The aim of this study was to evaluate the efficacy of injection of plasma rich in growth factors (PRGF) after temporomandibular joint (TMJ) arthroscopy in patients with Wilkes stage IV internal derangement. Ninety-two patients were randomized to two experimental groups: group A (42 joints) received injections of PRGF, group B (50 joints) received saline injections. Pain intensity on a visual analogue scale (VAS) and maximum mouth opening (MMO, mm) were measured before and after surgery and compared by analysis of variance (ANOVA). The mean age of patients was 35.8 years (range 17-67 years); 86 were female. Significant reductions in pain were noted in both groups after surgery: VAS 7.9 preoperative and 1.4 at 24 months postoperative. Significantly better clinical results were achieved in group A than in group B only at 6 and 12 months postoperative; no significant difference was noted at 18 or 24 months after the surgical intervention. MMO increased after surgery in both groups: 26.2mm preoperative and 36.8mm at 24 months postoperative. No significant differences in MMO were found when the two groups of patients were compared. In conclusion, the injection of PRGF does not add any significant improvement to clinical outcomes at 2 years after surgery in patients with advanced internal derangement of the TMJ.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Povisa Hospital, Vigo, Pontevedra, Spain. Electronic address: jsanroman@povisa.es.
authors.forename: J
authors.initials: J
authors.lastname: Fernández Sanromán
authors.affiliation: Department of Oral and Maxillofacial Surgery, Povisa Hospital, Vigo, Pontevedra, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Fernández Ferro
authors.affiliation: Department of Oral and Maxillofacial Surgery, Povisa Hospital, Vigo, Pontevedra, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Costas López
authors.affiliation: Department of Oral and Maxillofacial Surgery, Povisa Hospital, Vigo, Pontevedra, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Arenaz Bua
authors.affiliation: Department of Oral and Maxillofacial Surgery, Povisa Hospital, Vigo, Pontevedra, Spain.
authors.forename: A
authors.initials: A
authors.lastname: López
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001182:Arthroscopy; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage*; D004204:Joint Dislocations; D008875:Middle Aged; D010147:Pain Measurement; D000073818:Procedural Pain / Q000188:drug therapy*; D011446:Prospective Studies; D016059:Range of Motion, Articular; D012189:Retrospective Studies; D012965:Sodium Chloride / Q000008:administration & dosage; D013704:Temporomandibular Joint / Q000601:surgery; D013705:Temporomandibular Joint Disorders / Q000188:drug therapy* / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D012965:Sodium Chloride
keywords: PRP; TMJ arthroscopy; TMJ arthrosis; plasma rich in growth factors; temporomandibular joint disorders