title: Survivin and Tumorigenesis: Molecular Mechanisms and Therapeutic Strategies.
abstract: Survivin is the smallest member of the inhibitor of apoptosis protein family, which has key roles in regulating cell division and inhibiting apoptosis by blocking caspase activation. Survivin is highly expressed in most human cancers, such as lung, pancreatic and breast cancers, relative to normal tissues. Aberrant survivin expression is associated with tumor cell proliferation, progression, angiogenesis, therapeutic resistance, and poor prognosis. Studies on the underlying molecular mechanisms indicate that survivin is involved in the regulation of cytokinesis and cell cycle progression, as well as participates in a variety of signaling pathways such as the p53, Wnt, hypoxia, transforming growth factor, and Notch signaling pathways. In this review, recent progress in understanding the molecular basis of survivin is discussed. Therapeutic strategies targeting survivin in preclinical studies are also briefly summarized.
authors.affiliation: 1. Hong-Hui Hospital, Xi'an Jiaotong University, College of Medicine, Xi'an, Shaanxi, China, 710054.
authors.forename: Xun
authors.initials: X
authors.lastname: Chen
authors.affiliation: 1. Hong-Hui Hospital, Xi'an Jiaotong University, College of Medicine, Xi'an, Shaanxi, China, 710054.
authors.forename: Ning
authors.initials: N
authors.lastname: Duan
authors.affiliation: 2. Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA, 80045.
authors.forename: Caiguo
authors.initials: C
authors.lastname: Zhang
authors.affiliation: 1. Hong-Hui Hospital, Xi'an Jiaotong University, College of Medicine, Xi'an, Shaanxi, China, 710054.
authors.forename: Wentao
authors.initials: W
authors.lastname: Zhang
keywords: apoptosis; cancer; cell cycle; survivin; therapy