title: Moderate Physical Activity Mediates the Association between White Matter Lesion Volume and Memory Recall in Breast Cancer Survivors.
abstract: Increased survival rates among breast cancer patients have drawn significant attention to consequences of both the presence of cancer, and the subsequent treatment-related impact on the brain. The incidence of breast cancer and the effects of treatment often result in alterations in the microstructure of white matter and impaired cognitive functioning. However, physical activity is proving to be a successful modifiable lifestyle factor in many studies that could prove beneficial to breast cancer survivors. This study investigates the link between white matter lesion volume, moderate physical activity, and cognition in breast cancer survivors following treatment compared to non-cancer age-matched controls. Results revealed that brain structure significantly predicted cognitive function via mediation of physical activity in breast cancer survivors. Overall, the study provided preliminary evidence suggesting moderate physical activity may help reduce the treatment related risks associated with breast cancer, including changes to WM integrity and cognitive impairment.
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.
authors.forename: Gillian E
authors.initials: GE
authors.lastname: Cooke
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.|Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Wetter
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.|Department of Psychology, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Banducci
authors.affiliation: Department of Behavioral Health and Nutrition, College of Health Sciences, University of Delaware, Newark, DE, United States of America.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Mackenzie
authors.affiliation: School of Family and Consumer Sciences, Texas State University, San Marcos, TX, United States of America.
authors.forename: Krystle E
authors.initials: KE
authors.lastname: Zuniga
authors.affiliation: Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Awick
authors.affiliation: Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Roberts
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.|Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.
authors.forename: Brad P
authors.initials: BP
authors.lastname: Sutton
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.|Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.
authors.forename: Edward
authors.initials: E
authors.lastname: McAuley
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.|Department of Psychology, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America.
authors.forename: Arthur F
authors.initials: AF
authors.lastname: Kramer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011939:Mental Recall; D008875:Middle Aged; D009043:Motor Activity; D017741:Survivors; D066127:White Matter / Q000473:pathology*; D055815:Young Adult