title: Alternative administration routes and delivery technologies for polio vaccines.
abstract: Global polio eradication is closer than ever. Replacement of the live attenuated oral poliovirus vaccine (OPV) by inactivated poliovirus vaccine (IPV) is recommended to achieve complete eradication. Limited global production capacity and relatively high IPV costs compared to OPV spur the need for improved polio vaccines. The target product profile of these vaccines includes not only dose sparing but also high stability, which is important for stockpiling, and easy application important for (emergency) vaccination campaigns. In this review, the current status of alternative polio vaccine delivery strategies is given. Furthermore, we discuss the feasibility of these strategies by highlighting challenges, hurdles to overcome, and formulation issues relevant for optimal vaccine delivery.
authors.affiliation: a Department of Research, Intravacc (Institute for Translational Vaccinology) , Bilthoven , The Netherlands.
authors.forename: Heleen
authors.initials: H
authors.lastname: Kraan
authors.affiliation: b Division of Drug Delivery Technology , Leiden Academic Center for Drug Research, Leiden University , Leiden , The Netherlands.
authors.forename: Wanda
authors.initials: W
authors.lastname: van der Stel
authors.affiliation: a Department of Research, Intravacc (Institute for Translational Vaccinology) , Bilthoven , The Netherlands.|b Division of Drug Delivery Technology , Leiden Academic Center for Drug Research, Leiden University , Leiden , The Netherlands.
authors.forename: Gideon
authors.initials: G
authors.lastname: Kersten
authors.affiliation: a Department of Research, Intravacc (Institute for Translational Vaccinology) , Bilthoven , The Netherlands.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Amorij
mesh_terms: D000818:Animals; D060740:Disease Eradication; D004339:Drug Compounding; D004355:Drug Stability; D006801:Humans; D011051:Poliomyelitis / Q000517:prevention & control*; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D011054:Poliovirus Vaccine, Inactivated
keywords: Inactivated poliovirus vaccine; dermal; mucosal; needle-free; vaccine delivery