title: Recent Insights Into Cardiovascular Disease (CVD) Risk Among HIV-Infected Adults.
abstract: While mortality rates related to cardiovascular disease (CVD) have decreased over time among adults with HIV, excess risk of CVD in the HIV-infected population may persist despite highly active antiretroviral therapy (HAART) treatment and aggressive CVD risk factor control. Beyond atherosclerotic CVD, recent studies suggest that HIV infection may be associated with left ventricular systolic and diastolic function, interstitial myocardial fibrosis, and increased cardiac fat infiltration. Thus, with the increasing average age of the HIV-infected population, heart failure and arrhythmic disorders may soon rival coronary artery disease as the most prevalent forms of CVD. Finally, the question of whether HIV infection should be considered in clinical risk stratification has never been resolved, and this question has assumed new importance with recent changes to lipid treatment guidelines for prevention of CVD.
authors.affiliation: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA. robert.kaplan@einstein.yu.edu.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Kaplan
authors.affiliation: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
authors.forename: David B
authors.initials: DB
authors.lastname: Hanna
authors.affiliation: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.|Department of Medicine (Cardiology), Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Kizer
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D050197:Atherosclerosis / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D003324:Coronary Artery Disease / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D006333:Heart Failure / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D019380:Anti-HIV Agents
keywords: Aging; CVD; Cardiovascular disease; Coronary heart disease; Epidemiology; HIV; HIV/AIDS; Review