title: Design and Concept of Polyzwitterionic Copolymer Microgel Drug Delivery Systems In Situ Loaded with Non-steroidal Anti-inflammatory Ibuprofen.
abstract: Nowadays, the modern pharmaceutical investigations are directed toward obtaining of new polymer micro- and nano-sized drug delivery carriers. In this respect, the use of hydrogel carriers based on polyzwitterions (PZIs) is an opportunity in the preparation of polymer drug delivery systems with desired characteristics. This paper describes the synthesis and characterization of micro-structured p(VA-co-DMAPS) systems with different compositions in situ loaded with Ibuprofen by emulsifier-free emulsion copolymerization (EEC) in water. The mean size of the prepared microparticles was measured by SEM and particles have been visualized by AFM. The inclusion of Ibuprofen in the polyzwitterionic copolymer microgel systems was established by using DSC. In vitro drug release experiments were carried out in order to estimate the ability of the obtained microgels to modify the release of water-insoluble Ibuprofen.
authors.affiliation: Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., Sofia, 1000, Bulgaria. bistrakostova@abv.bg.
authors.forename: Bistra
authors.initials: B
authors.lastname: Kostova
authors.affiliation: Faculty of Chemistry and Pharmacy, Sofia University, 1 James Bourchier Ave., Sofia, 1164, Bulgaria.
authors.forename: Elena
authors.initials: E
authors.lastname: Kamenska
authors.affiliation: Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., Sofia, 1000, Bulgaria. diljana1977@abv.bg.
authors.forename: Dilyana
authors.initials: D
authors.lastname: Georgieva
authors.affiliation: Faculty of Chemistry and Pharmacy, Sofia University, 1 James Bourchier Ave., Sofia, 1164, Bulgaria.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Balashev
authors.affiliation: Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., Sofia, 1000, Bulgaria.
authors.forename: Dimitar
authors.initials: D
authors.lastname: Rachev
authors.affiliation: Faculty of Chemistry and Pharmacy, Sofia University, 1 James Bourchier Ave., Sofia, 1164, Bulgaria.
authors.forename: George
authors.initials: G
authors.lastname: Georgiev
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D004655:Emulsions / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D004655:Emulsions; D011108:Polymers; D014867:Water; D007052:Ibuprofen
keywords: drug delivery systems; ibuprofen; microparticles; polymer carriers; polyzwitterions