title: A 1-Year-Old with Mycobacterium tuberculosis Endocarditis with Mass Spectrometry Analysis of Cardiac Vegetation Composition.
abstract: In this study, we report the first case of Mycobacterium tuberculosis endocarditis in an immunocompetent child born in the United States. Mass spectrometry of the vegetation identified coagulation, humoral immune proteins, neutrophil granule proteins, and histones. Few neutrophils on histopathology suggest that neutrophil extracellular traps may contribute to tuberculous endocardiac mass formation.
authors.affiliation: The Departments of Pediatrics The Children's Hospital of The King's Daughters, Norfolk, Virginia Children's Specialty Group, Norfolk, Virginia.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Sass
authors.affiliation: The Departments of Pediatrics.
authors.forename: Keegan J
authors.initials: KJ
authors.lastname: Ziemba
authors.affiliation: The Departments of Pediatrics.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Heiser
authors.affiliation: The Departments of Pediatrics.
authors.forename: Clifford T
authors.initials: CT
authors.lastname: Mauriello
authors.affiliation: The Departments of Pediatrics The Children's Hospital of The King's Daughters, Norfolk, Virginia Children's Specialty Group, Norfolk, Virginia.
authors.forename: Alice L
authors.initials: AL
authors.lastname: Werner
authors.affiliation: The Departments of Pediatrics The Children's Hospital of The King's Daughters, Norfolk, Virginia Children's Specialty Group, Norfolk, Virginia.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Aguiar
authors.affiliation: Microbiology The Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia.
authors.forename: Julius O
authors.initials: JO
authors.lastname: Nyalwidhe
authors.affiliation: The Departments of Pediatrics Microbiology The Children's Hospital of The King's Daughters, Norfolk, Virginia Children's Specialty Group, Norfolk, Virginia.
authors.forename: Kenji M
authors.initials: KM
authors.lastname: Cunnion
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000382:microbiology / Q000473:pathology; D002853:Chromatography, Liquid; D004697:Endocarditis, Bacterial / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000276:immunology; D004699:Endocardium / Q000737:chemistry; D005260:Female; D006801:Humans; D007121:Immunocompetence; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000382:microbiology / Q000473:pathology; D013058:Mass Spectrometry; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D009504:Neutrophils / Q000276:immunology; D017293:Protein S / Q000032:analysis; D014381:Tuberculosis, Cardiovascular / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000276:immunology; D014481:United States
chemical_list: D000995:Antitubercular Agents; D017293:Protein S
keywords: endocarditis; hemophagocytic lymphohistiocytosis; mass spectrometry; neutrophil extracellular traps; tuberculosis