title: Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase.
abstract: Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity.
authors.affiliation: Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, VIC 3168, Australia.
authors.forename: Dragana
authors.initials: D
authors.lastname: Odobasic
authors.affiliation: Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, VIC 3168, Australia; Department of Nephrology, Monash Health, Clayton, VIC 3168, Australia.
authors.forename: A Richard
authors.initials: AR
authors.lastname: Kitching
authors.affiliation: Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, VIC 3168, Australia; Department of Nephrology, Monash Health, Clayton, VIC 3168, Australia.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Holdsworth
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D001419:Bacteria / Q000276:immunology; D065206:Extracellular Traps / Q000276:immunology / Q000382:microbiology / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D009504:Neutrophils / Q000201:enzymology* / Q000276:immunology*; D009195:Peroxidase / Q000172:deficiency / Q000378:metabolism*
chemical_list: D009195:Peroxidase