title: Antidepressant-Like Effects of Lindera obtusiloba Extracts on the Immobility Behavior of Rats in the Forced Swim Test.
abstract: Lindera obtusiloba extracts are commonly used as an alternative medicine due to its numerous health benefits in Korea. However, the antidepressant-like effects of L. obtusiloba extracts have not been fully elucidated. In this study, we aimed to determine whether L. obtusiloba extracts exhibited antidepressant-like activity in rats subjected to forced swim test (FST)-induced depression. Acute treatment of rats with L. obtusiloba extracts (200 mg/kg, p.o.) significantly reduced immobility time and increased swimming time without any significant change in climbing. Rats treated with L. obtusiloba extracts also exhibited a decrease in the limbic hypothalamic-pituitary-adrenal (HPA) axis response to the FST, as indicated by attenuation of the corticosterone response and decreased c-Fos immunoreactivity in the hippocampus CA3 region. In addition, L. obtusiloba extracts, at concentrations that were not affected by cell viability, significantly decreased luciferase activity in response to cortisol in a concentration-dependent manner by the glucocorticoid binding assay in HeLa cells. Our findings suggested that the antidepressant-like effects of L. obtusiloba extracts were likely mediated via the glucocorticoid receptor (GR). Further studies are needed to evaluate the potential of L. obtusiloba extracts as an alternative therapeutic approach for the treatment of depression.
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 463-746, Korea. neodw4015@kfri.re.kr.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Lim
authors.affiliation: Division of Bio-Imaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon 200-701, Korea. mslee0621@gmail.com.
authors.forename: Mi-Sook
authors.initials: MS
authors.lastname: Lee
authors.affiliation: Division of Bio-Imaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon 200-701, Korea. swher@kbsi.re.kr.
authors.forename: Song
authors.initials: S
authors.lastname: Her
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 463-746, Korea. smcho@kfri.re.kr.
authors.forename: Suengmok
authors.initials: S
authors.lastname: Cho
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 463-746, Korea. chang@kfri.re.k.
authors.forename: Chang-Ho
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 463-746, Korea. skihs@kfri.re.kr.
authors.forename: In-Ho
authors.initials: IH
authors.lastname: Kim
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 463-746, Korea. imissu@kfri.re.kr.
authors.forename: Daeseok
authors.initials: D
authors.lastname: Han
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004195:Disease Models, Animal; D006367:HeLa Cells; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D027443:Lindera / Q000737:chemistry*; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011965:Receptors, Glucocorticoid; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D010936:Plant Extracts; D011965:Receptors, Glucocorticoid
keywords: Lindera obtusiloba; depression; forced swim test; glucocorticoid receptor; hypothalamic-pituitary-adrenal axis