title: Extraintestinal Infections Caused by Non-toxigenic Vibrio cholerae non-O1/non-O139.
abstract: Vibrio cholerae is an aerobic, sucrose fermentative Gram-negative bacterium that generally prevails in the environment. Pathogenic V. cholerae is well-known as causative agent of acute diarrhea. Apart from enteric infections, V. cholerae may also cause other diseases. However, their role in causing extraintestinal infections is not fully known as it needs proper identification and evaluation. Four cases of extraintestinal infections due to V. cholerae non-O1/non-O139 have been investigated. The isolates were screened for phenotypic and genetic characteristics with reference to their major virulence genes. Serologically distinct isolates harbored rtx, msh, and hly but lacked enteric toxin encoding genes that are generally present in toxigenic V. cholerae. Timely detection of this organism can prevent fatalities in hospital settings. The underlying virulence potential of V. cholerae needs appropriate testing and intervention.
authors.affiliation: Department of Bacteriology, National Institute of Cholera and Enteric Diseases Kolkata, India.
authors.forename: Goutam
authors.initials: G
authors.lastname: Chowdhury
authors.affiliation: Manipal Hospital Bangalore, India.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Joshi
authors.affiliation: Tata Medical Center Kolkata, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Bhattacharya
authors.affiliation: Sri Ramachandra Medical Centre Chennai, India.
authors.forename: Uma
authors.initials: U
authors.lastname: Sekar
authors.affiliation: Metropolis Healthcare Ltd-Global Hospital Mumbai, India.
authors.forename: Balaji
authors.initials: B
authors.lastname: Birajdar
authors.affiliation: Tata Medical Center Kolkata, India.
authors.forename: Arpita
authors.initials: A
authors.lastname: Bhattacharyya
authors.affiliation: Collaborative Research Centre of Okayama University for Infectious Diseases in India, National Institute of Cholera and Enteric Diseases Kolkata, India.
authors.forename: Sumio
authors.initials: S
authors.lastname: Shinoda
authors.affiliation: Translational Health Science and Technology Institute, NCR Biotech Science Cluster Faridabad, India.
authors.forename: Thandavarayan
authors.initials: T
authors.lastname: Ramamurthy
keywords: UTI; V. cholerae; hematuria; ompW-PCR; septicaemia; serogroup identification