title: An Unusual Variant of Hepatic Inflammatory Angiomyolipoma: Report of a Rare Entity.
abstract: Hepatic angiomyolipoma is a rare mesenchymal tumor with a broad spectrum of histological appearance. A 44-year-old female presented with abdominal discomfort. MRI revealed a 3.6 cm well-defined hepatic lesion. Ultrasound-guided core biopsy with imprint smears was performed. The smears showed histiocytes with a few epithelioid cells, mimicking an inflammatory lesion. The biopsy showed proliferation of epithelioid cells with aggregates of foamy histiocytes and scattered adipocyts, resembling hepatocellular neoplasm. The diagnosis of angiomyolipoma was clinched by the immunoprofile of the epithelioid cells, which were diffusely positive for HMB45, Mart-1 and focally positive for smooth muscle actin. To our best knowledge, this is the first reported case of biopsy diagnosed hepatic inflammatory angiomyolipoma with an unusual inflammatory infiltrate composed mainly of aggregates of foamy histiocytes.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas Health Science Center - Medical School at Houston, Houston, TX, USA.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas Health Science Center - Medical School at Houston, Houston, TX, USA Department of Pathology, LBJ General Hospital, Houston, TX, USA mary.y.yang@uth.tmc.edu.
authors.forename: Mary
authors.initials: M
authors.lastname: Yang
mesh_terms: D000328:Adult; D018207:Angiomyolipoma / Q000000981:diagnostic imaging / Q000473:pathology*; D015622:Epithelioid Cells / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: hepatic angiomyolipoma; hepatocellular neoplasm; inflammatory variant