title: CAMK4 gene variation is associated with hypertension in a Uygur population.
abstract: Considering that calcium/calmodulin-dependent kinase 4 (CAMK4) plays a pivotal role in blood pressure regulation, we investigated the association between a CAMK4 polymorphism (rs10491334) and hypertension in the Han, Kazak, and Uygur ethnic groups. We studied 1224 patients with hypertension and 967 normotensive controls classified into three ethnic groups (Han, Kazak, and Uygur). The rs10491334 polymorphism was genotyped using a TaqMan® 5'-nuclease assay. In the Uygur group, the T-allele frequency in patients with hypertension was twice that of the controls (12.5 vs 6.38%), and T-allele carriers had a significantly increased risk of hypertension compared with non-carriers (odds ratio = 2.200; 95% confidence interval = 1.473-3.285, P < 0.001). However, no significant correlation was found in the Han and Kazak groups. The T-allele of rs10491334 in CAMK4 was associated with hypertension in the Uygur group.
authors.affiliation: Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.|Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, Xinjiang, China.
authors.forename: S Z
authors.initials: SZ
authors.lastname: Chen
authors.affiliation: Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.|Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, Xinjiang, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: L N
authors.initials: LN
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, Xinjiang, China.
authors.forename: G L
authors.initials: GL
authors.lastname: Lu
authors.affiliation: Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: C M
authors.initials: CM
authors.lastname: Zhou
authors.affiliation: Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: D W
authors.initials: DW
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The People's Hospital of Tacheng, Tacheng, Xinjiang, China.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Tang
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, Xinjiang, China.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, Xinjiang, China.
authors.forename: L
authors.initials: L
authors.lastname: Qin
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, Xinjiang, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Zhai
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4 / Q000235:genetics*; D016022:Case-Control Studies; D005006:Ethnicity; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: C517683:CAMK4 protein, human; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4