title: Ultrathin MXene-Micropattern-Based Field-Effect Transistor for Probing Neural Activity.
abstract: A field-effect transistor (FET) based on ultrathin Ti3 C2 -MXene micropatterns is developed and utilized as a highly sensitive biosensor. The device is produced with the microcontact printing technique, making use of its unique advantages for easy fabrication. Using the MXene-FET device, label-free probing of small molecules in typical biological environments and fast detection of action potentials in primary neurons is demonstrated.
authors.affiliation: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Ave, Kowloon, Hong Kong SAR, 999077, P. R. China.
authors.forename: Bingzhe
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Physics and Material Science, City University of Hong Kong, 83 Tat Chee Ave, Kowloon, Hong Kong SAR, 999077, P. R. China.
authors.forename: Minshen
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Ave, Kowloon, Hong Kong SAR, 999077, P. R. China.
authors.forename: Wencong
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Ave, Kowloon, Hong Kong SAR, 999077, P. R. China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhen
authors.affiliation: Department of Physics and Material Science, City University of Hong Kong, 83 Tat Chee Ave, Kowloon, Hong Kong SAR, 999077, P. R. China.
authors.forename: Zengxia
authors.initials: Z
authors.lastname: Pei
authors.affiliation: Department of Physics and Material Science, City University of Hong Kong, 83 Tat Chee Ave, Kowloon, Hong Kong SAR, 999077, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xue
authors.affiliation: Department of Physics and Material Science, City University of Hong Kong, 83 Tat Chee Ave, Kowloon, Hong Kong SAR, 999077, P. R. China.
authors.forename: Chunyi
authors.initials: C
authors.lastname: Zhi
authors.affiliation: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Ave, Kowloon, Hong Kong SAR, 999077, P. R. China.|Shenzhen Research Institute, City University of Hong Kong, Shenzhen, 518057, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Shi
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation*; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D004298:Dopamine / Q000032:analysis; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D011327:Printing; D051381:Rats; D017207:Rats, Sprague-Dawley; D014025:Titanium / Q000737:chemistry*; D014173:Transistors, Electronic
chemical_list: C096521:titanium carbide; D014025:Titanium; D002118:Calcium; D004298:Dopamine
keywords: MXenes biosensors; dopamine detection; field-effect transistors; micropatterning; neural engineering