title: One-year maintenance with routine assessment of patient index data 3-based remission may inhibit radiographic progression in patients with rheumatoid arthritis treated with routine clinical therapy: A retrospective comparison of radiographic outcome and its prognostic factors between maintained remissions with patient-reported outcome index and physician-oriented disease activity indices.
abstract: OBJECTIVE
  We investigated whether the maintenance of routine assessment of patient index data 3 (RAPID3) remission for one year (RAPID3-MR) may predict good radiographic outcomes. We also compared radiographic progression to prognostic factors among patients with RAPID3-MR, with the maintenance of clinical disease activity index remission for one year (CDAI-MR) or with the maintenance of 28 joint count disease activity score remission for one year (DAS28-MR).
  
  
  METHODS
  Of 1220 patients with available clinical data, 92 with RAPID3-MR, 80 with RAPID3-NMR (not satisfying RAPID3-MR), 45 with CDAI-MR, and 75 with DAS28-MR were retrospectively investigated. CDAI and DAS28 for clinical outcomes and the modified total Sharp score (mTSS) for radiographic joint damage were investigated for at least one year.
  
  
  RESULTS
  RAPID3, CDAI, DAS28, and their categories remained unchanged or significantly improved in RAPID3-MR patients but significantly deteriorated in RAPID3-NMR patients. The mean annual ΔmTSS was significantly lower in RAPID3-MR patients (0.12 ± 0.55) than in RAPID3-NMR patients (0.54 ± 1.27) (p = 0.025). There was no significant difference among RAPID3-MR patients, CDAI-MR patients (0.06 ± 0.85), and DAS28-MR patients (0.11 ± 0.89). The baseline mTSS (p = 0.038) and monotherapy with nonbiological disease-modifying antirheumatic drugs (p = 0.033) were good prognostic factors in RAPID3-MR patients.
  
  
  CONCLUSIONS
  One-year RAPID3 remission maintenance may predict good radiographic outcomes.
authors.affiliation: a Katayama Orthopedic Rheumatology Clinic , Hokkaido , Japan.
authors.forename: Kou
authors.initials: K
authors.lastname: Katayama
authors.affiliation: a Katayama Orthopedic Rheumatology Clinic , Hokkaido , Japan.
authors.forename: Takanobu
authors.initials: T
authors.lastname: Okubo
authors.affiliation: a Katayama Orthopedic Rheumatology Clinic , Hokkaido , Japan.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Sato
authors.affiliation: a Katayama Orthopedic Rheumatology Clinic , Hokkaido , Japan.
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Kamiya
authors.affiliation: b Seien Pharmacy , Hokkaido , Japan.
authors.forename: Richio
authors.initials: R
authors.lastname: Fukai
authors.affiliation: c Department of Orthopedic Surgery , Asahikawa Medical University , Hokkaido , Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Abe
authors.affiliation: c Department of Orthopedic Surgery , Asahikawa Medical University , Hokkaido , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
authors.affiliation: d Department of Medicine, Division of Metabolism and Biosystemic Science , Asahikawa Medical University , Hokkaido , Japan , and.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Makino
authors.affiliation: e Faculty of Health Science , Hokkaido University , Hokkaido , Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Kamishima
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000188:drug therapy*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071066:Patient Reported Outcome Measures; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D018501:Antirheumatic Agents
keywords: Modified total Sharp score; One-year maintenance; RAPID3; Remission; Rheumatoid arthritis