title: iPSCs-based anti-aging therapies: Recent discoveries and future challenges.
abstract: The main biological hallmarks of the aging process include stem cell exhaustion and cellular senescence. Consequently, research efforts to treat age-related diseases as well as anti-aging therapies in general have recently focused on potential 'reprogramming' regenerative therapies. These new approaches are based on induced pluripotent stem cells (iPSCs), including potential in vivo reprogramming for tissue repair. Another possibility is targeting pathways of cellular senescence, e.g., through modulation of p16INK4a signaling and especially inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Here, we reviewed and discussed these recent developments together with their possible usefulness for future treatments against sarcopenia, a major age-related condition.
authors.affiliation: European University of Madrid, Spain; Research Institute of Hospital 12 de Octubre ("i+12"), Madrid, Spain. Electronic address: helios.pareja@uem.es.
authors.forename: Helios
authors.initials: H
authors.lastname: Pareja-Galeano
authors.affiliation: Research Institute of Hospital 12 de Octubre ("i+12"), Madrid, Spain.
authors.forename: Fabián
authors.initials: F
authors.lastname: Sanchis-Gomar
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Pérez
authors.affiliation: 2E Science, Robbio, PV, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: Emanuele
authors.affiliation: European University of Madrid, Spain; Research Institute of Hospital 12 de Octubre ("i+12"), Madrid, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
authors.affiliation: European University of Madrid, Spain; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
authors.forename: Beatriz G
authors.initials: BG
authors.lastname: Gálvez
authors.affiliation: Research Institute of Hospital 12 de Octubre ("i+12"), Madrid, Spain; Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain; Instituto de Investigaciones Biomédicas "Alberto Sols" (UAM-CSIC) and Centro de Investigación Biomédica en Red (CIBERER), Spain.
authors.forename: María Esther
authors.initials: ME
authors.lastname: Gallardo
mesh_terms: D000375:Aging / Q000502:physiology*; D065150:Cellular Reprogramming; D000067470:Cellular Reprogramming Techniques / Q000379:methods / Q000639:trends; D016922:Cellular Senescence / Q000502:physiology; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology*; D055948:Sarcopenia / Q000473:pathology / Q000503:physiopathology / Q000628:therapy
keywords: DOT1L; In vivo reprogramming; Induced pluripotent stem cells; Regenerative medicine; Sarcopenia