title: [Immune mechanisms of the active ingredients of Chinese medicinal herbs for chronic prostatitis].
abstract: Chronic prostatitis is a common male disease, and its pathogenesis is not yet clear. Most scholars believe that oxidative stress and immune imbalance are the keys to the occurrence and progression of chronic prostatitis. Currently immunotherapy of chronic prostatitis remains in the exploratory stage. This article relates the active ingredients of 5 Chinese medicinal herbs (total glucosides of paeony, tripterigium wilfordii polglycosidium, curcumin, geniposide, and quercetin) for the treatment of chronic prostatitis and their possible action mechanisms as follows: 1) inhibiting the immune response and activation and proliferation of T-cells, and adjusting the proportion of Th1/Th2 cells; 2) upregulating the expression of Treg and enhancing the patient's tolerability; 3) suppressing the activation of the NF-kB factor, reducing the release of iNOS, and further decreasing the release of NO, IL-2 and other inflammatory cytokines, which contribute to the suppression of the immune response; 4) inhibiting the production of such chemokines as MCP-1 and MIP-1α in order to reduce their induction of inflammatory response. Studies on the immune mechanisms of Chinese medicinal herbs in the treatment of chronic prostatitis are clinically valuable for the development of new drugs for this disease.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Yu-chun
authors.initials: YC
authors.lastname: Zhou
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: Xue
mesh_terms: D018925:Chemokines / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D008297:Male; D052002:NF-kappa B p50 Subunit / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D010946:Plants, Medicinal; D011472:Prostatitis / Q000188:drug therapy* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects; D058408:Th1-Th2 Balance
chemical_list: D018925:Chemokines; D016207:Cytokines; D004365:Drugs, Chinese Herbal; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II