title: Different evolutionary patterns of classical swine fever virus envelope proteins.
abstract: Classical swine fever virus (CSFV) is the causative agent of classical swine fever, which is a highly contagious disease of the domestic pig as well as wild boar. The proteins E(rns), E1, and E2 are components of the viral envelope membrane. They are also implicated in virus attachment and entry, replication, and (or) anti-immune response. Here, we studied the genetic variations of these envelope proteins in the evolution of CSFV. The results reveal that the envelope proteins underwent different evolutionary fates. In E(rns) and E1, but not E2, a number of amino acid sites experienced functional divergence. Furthermore, the diversification in E(rns) and E1 was generally episodic because the divergence-related changes of E1 only occurred with the separation of 2 major groups of CSFV and that of E(rns) took place with the division of 1 major group. The major divergence-related sites of E(rns) are located on one of the substrate-binding regions of the RNase domain and C-terminal extension. These functional domains have been reported to block activation of the innate immune system and attachment and entry into host cells, respectively. Our results may shed some light on the divergent roles of the envelope proteins.
authors.affiliation: a College of Animal Science and Technology, Sichuan Agricultural University, Wenjiang, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: b College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, People's Republic of China.
authors.forename: Zexiao
authors.initials: Z
authors.lastname: Yang
authors.affiliation: a College of Animal Science and Technology, Sichuan Agricultural University, Wenjiang, People's Republic of China.
authors.forename: Mingwang
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000818:Animals; D006692:Classical Swine Fever Virus / Q000145:classification* / Q000235:genetics; D019143:Evolution, Molecular; D014644:Genetic Variation; D010802:Phylogeny; D013552:Swine; D014759:Viral Envelope Proteins / Q000235:genetics*
chemical_list: D014759:Viral Envelope Proteins
keywords: adaptive diversification; classical swine fever virus; configurations distinctes; different patterns; diversification adaptative; envelope proteins; protéines de l’enveloppe; virus de la peste porcine classique