title: Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition.
abstract: In most animal species, juvenile growth is marked by an exponential gain in body weight and size. Here we show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet. We found that the intestinal microbiota interacts with the somatotropic hormone axis to drive systemic growth. Using monocolonized mouse models, we showed that selected lactobacilli promoted juvenile growth in a strain-dependent manner that recapitulated the microbiota's effect on growth and the somatotropic axis. These findings show that the host's microbiota supports juvenile growth. Moreover, we discovered that lactobacilli strains buffered the adverse effects of chronic undernutrition on the postnatal growth of germ-free mice.
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Schwarzer
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. Laboratoire CarMeN, Université Lyon 1, Unité Mixte de Recherche INSERM U-1060 et INRA U-1397, Faculté de Médecine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France.
authors.forename: Kassem
authors.initials: K
authors.lastname: Makki
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Storelli
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
authors.forename: Irma
authors.initials: I
authors.lastname: Machuca-Gayet
authors.affiliation: Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Srutkova
authors.affiliation: Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.
authors.forename: Petra
authors.initials: P
authors.lastname: Hermanova
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Martino
authors.affiliation: UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Université de Lyon, INRA, INSA-Lyon, F-69621 Villeurbanne, France.
authors.forename: Severine
authors.initials: S
authors.lastname: Balmand
authors.affiliation: Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.
authors.forename: Tomas
authors.initials: T
authors.lastname: Hudcovic
authors.affiliation: UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Université de Lyon, INRA, INSA-Lyon, F-69621 Villeurbanne, France.
authors.forename: Abdelaziz
authors.initials: A
authors.lastname: Heddi
authors.affiliation: Laboratoire CarMeN, Université Lyon 1, Unité Mixte de Recherche INSERM U-1060 et INRA U-1397, Faculté de Médecine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rieusset
authors.affiliation: Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Kozakova
authors.affiliation: Laboratoire CarMeN, Université Lyon 1, Unité Mixte de Recherche INSERM U-1060 et INRA U-1397, Faculté de Médecine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France.
authors.forename: Hubert
authors.initials: H
authors.lastname: Vidal
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
authors.forename: François
authors.initials: F
authors.lastname: Leulier
mesh_terms: D000818:Animals; D001835:Body Weight / Q000502:physiology*; D004032:Diet; D005269:Femur / Q000254:growth & development; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D048191:Lactiplantibacillus plantarum / Q000502:physiology*; D044342:Malnutrition / Q000382:microbiology* / Q000503:physiopathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D015430:Weight Gain / Q000502:physiology*