title: LDH (Lactate Dehydrogenase): A Biochemical Marker for the Prediction of Adverse Outcomes in Pre-eclampsia and Eclampsia.
abstract: OBJECTIVE
  The aim of the study was to find out the role of Serum lactate dehydrogenase in prediction of adverse outcomes of PE & E i.e., severity of disease and occurrence of complications.
  
  
  METHODS
  This study was conducted in the Department of Obstetrics and Gynaecology, MGM Medical College, Indore. A total of 200 women were studied; they were divided into control (n = 100), severe pre-eclampsia (n = 32), eclampsia (n = 68). Demographic and hematological parameters were studied including LDH levels.
  
  
  RESULTS
  The incidence of severe pre-eclampsia-1.2 % & Eclampsia 2.7 %, PE & E patients were significantly younger, with low gravidity and parity. They had significantly increased systolic and diastolic pressure, liver enzymes, uric acid, urine albumin, and LDH levels. Serum urea and creatinine were normal in majority of cases. The symptoms and complications of PE along with perinatal mortality were increased significantly in patients with LDH >800 IU/l compared with those who had lower levels. Complications like Retinopathy, ARF, Abruptio, DIC, CVA, MODS, Shock were also associated with high level of serum LDH >800 IU/L. Low birth weight of babies was also associated with high level of serum LDH levels in PE & E patients. The incidence of poor perinatal outcome was higher in PE & E patients with high serum LDH level (>600 IU/L).
  
  
  CONCLUSIONS
  LDH is the earliest marker seen in blood during hypoxia and oxidative stress. It is a useful biochemical marker that reflects the severity of and the occurrence of complications of PE & E; these are preventable if identified at an earlier stage and adequately managed at a higher center. Test is easily available, so screening of all cases of PE & E with LDH levels must be made mandatory.
authors.affiliation: Department of Obstetrics and Gynaecology, M. Y. Hospital & MGM Medical College, 314, Saket Nagar, Indore, 452018 Madhya Pradesh India.
authors.forename: Anupama
authors.initials: A
authors.lastname: Dave
authors.affiliation: Department of Obstetrics and Gynaecology, M. Y. Hospital & MGM Medical College, 314, Saket Nagar, Indore, 452018 Madhya Pradesh India.
authors.forename: Laxmi
authors.initials: L
authors.lastname: Maru
authors.affiliation: Department of Obstetrics and Gynaecology, M. Y. Hospital & MGM Medical College, 314, Saket Nagar, Indore, 452018 Madhya Pradesh India.
authors.forename: Astha
authors.initials: A
authors.lastname: Jain
keywords: Biochemical marker; LDH; Preeclampsia & eclampsia; Serum lactate dehydrogenase