title: A Case of Myxofibrosarcoma in an Unusual Thoracic Location.
abstract: Myxofibrosarcoma is a soft tissue neoplasm composed of malignant fibroblasts with a myxoid matrix. It is commonly found in patients during their 6th through 8th decades of life with a slight male predominance. Myxofibrosarcomas are classified as low- to high-grade tumors that are differentiated by hypercellularity, variation of mitotic activity and degree of necrosis. The most common sites are the extremities (77%) and trunk (12%), with the retroperitoneum and mediastinum being very rare. In this case report, we describe a patient presenting with myxofibrosarcoma of the mediastinum, a rare site for the development of myxofibrosarcoma. This case of primary mediastinal myxofibrosarcoma appears to be only the second described in the English-language literature.
authors.affiliation: Bridgeport Hospital, Yale New Haven Health, Bridgeport, Conn., USA.
authors.forename: Kavitha
authors.initials: K
authors.lastname: Gopalratnam
authors.affiliation: Bridgeport Hospital, Yale New Haven Health, Bridgeport, Conn., USA.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Rodriguez
authors.affiliation: Bridgeport Hospital, Yale New Haven Health, Bridgeport, Conn., USA.
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Woodson
authors.affiliation: Yale Cancer Center, New Haven, Conn., USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Folman
keywords: Myxofibrosarcoma; Primary mediastinal myxofibrosarcoma; Thoracic location