title: Shift Work: A Risk Factor for Central Serous Chorioretinopathy.
abstract: To investigate if shift work or sleep disturbances are risk factors for central serous chorioretinopathy (CSCR).
  
  
  
  Prospective case-control study.
  
  
  
  Forty patients with active CSCR and 40 controls (age- and sex-matched) were prospectively recruited from the Ophthalmology Department of Hôtel Dieu Hospital, Paris, between November 2013 and December 2014. All patients were asked to complete a questionnaire addressing previously described risk factors and working hours, as well as the Insomnia Severity Index (ISI), a validated instrument for assessing sleep disturbances.
  
  
  
  The mean age of the CSCR group was 44 ± 9 years, whereas the mean age of the control group was 43 ± 10 years. By use of multivariate analysis, shift work (odds ratio [OR] [95% confidence interval]: 5 [1.2-20.4]; P = .02), steroid use (OR: 5.5 [1.1-26.2]; P = .03), and recent psychological stress (OR: 15.3 [4.1-54.5]; P < .001) were found to be independently associated with CSCR.
  
  
  
  The outcomes of this study suggest that shift work is an independent risk factor of CSCR. Further studies are required to confirm these results and to examine if work reconversion would be beneficial in the treatment of patients with chronic/recurrent CSCR.
authors.affiliation: Department of Ophthalmology, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France; Inserm U1138, Team 17, Université Sorbonne Paris Cité, Université Pierre et Marie Curie, Centre de Recherche des Cordeliers, Paris, France. Electronic address: bousquetelodie@hotmail.fr.
authors.forename: Elodie
authors.initials: E
authors.lastname: Bousquet
authors.affiliation: Department of Ophthalmology, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Dhundass
authors.affiliation: Department of Ophthalmology, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Lehmann
authors.affiliation: Department of Ophthalmology, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France; Inserm U1138, Team 17, Université Sorbonne Paris Cité, Université Pierre et Marie Curie, Centre de Recherche des Cordeliers, Paris, France.
authors.forename: Pierre-Raphaël
authors.initials: PR
authors.lastname: Rothschild
authors.affiliation: Sleep and Vigilance Center, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Bayon
authors.affiliation: Sleep and Vigilance Center, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Leger
authors.affiliation: Department of Ophthalmology University of Lausanne, Jules Gonin Ophthalmic Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.
authors.forename: Ciara
authors.initials: C
authors.lastname: Bergin
authors.affiliation: Department of Ophthalmology University of Lausanne, Jules Gonin Ophthalmic Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.
authors.forename: Ali
authors.initials: A
authors.lastname: Dirani
authors.affiliation: Department of Ophthalmology, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France.
authors.forename: Talal
authors.initials: T
authors.lastname: Beydoun
authors.affiliation: Inserm U1138, Team 17, Université Sorbonne Paris Cité, Université Pierre et Marie Curie, Centre de Recherche des Cordeliers, Paris, France; Department of Ophthalmology University of Lausanne, Jules Gonin Ophthalmic Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.
authors.forename: Francine
authors.initials: F
authors.lastname: Behar-Cohen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D020178:Sleep Disorders, Circadian Rhythm / Q000175:diagnosis / Q000453:epidemiology*; D013315:Stress, Psychological / Q000175:diagnosis / Q000453:epidemiology*; D011795:Surveys and Questionnaires; D014940:Work Schedule Tolerance; D055815:Young Adult