title: Intramedullary nailing versus external fixation in Gustilo type III open tibial shaft fractures: a meta-analysis of randomised controlled trials.
abstract: Open tibial shaft fractures are the most common of long-bone open fractures. Management of the fracture is either by intramedullary nailing (IMN) or by external fixation (EF). Since the literature does not indicate clearly which is more effective, a meta-analysis was conducted to establish which approach is more suitable to treat Gustilo type III fractures. MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE and CINAHL databases were searched for randomised controlled trials (RCT) describing IMN and EF treatment of Gustilo type III fractures. As of 15 November 2012, five RCT involving 239 patients had been published; the outcomes examined in this study are their surgical complications. Data analysis led complications to be grouped into infection, fracture healing problems (non-union, malunion) and "other complications" (vascular injury, revision surgery, soft tissue damage, mechanical failure and tibial malalignment). IMN was associated with lower rates of infection and fracture healing problems; the differences between the two approaches for "other complications" were not significant. The data indicate that IMN is the treatment of choice for Gustilo type III fractures.
authors.affiliation: Clinica di Ortopedia, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona, Università Politecnica delle Marche, Via Conca, Torrette, 60100, Ancona, Italy. francescagiov@hotmail.com.
authors.forename: Francesca
authors.initials: F
authors.lastname: Giovannini
authors.affiliation: Clinica di Ortopedia, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona, Università Politecnica delle Marche, Via Conca, Torrette, 60100, Ancona, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: de Palma
authors.affiliation: Clinica di Ortopedia, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona, Università Politecnica delle Marche, Via Conca, Torrette, 60100, Ancona, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Panfighi
authors.affiliation: Clinica di Ortopedia, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona, Università Politecnica delle Marche, Via Conca, Torrette, 60100, Ancona, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Marinelli
keywords: External fixation; Intramedullary nailing; Open tibia fractures