title: Digital X-ray radiogrammetry in the study of osteoporotic fractures: Comparison to dual energy X-ray absorptiometry and FRAX.
abstract: Osteoporosis is often underdiagnosed and undertreated. Screening of post-menopausal women for clinical risk factors and/or low bone mineral density (BMD) has been proposed to overcome this. Digital X-ray radiogrammetry (DXR) estimates hand BMD from standard hand X-ray images and have shown to predict fractures and osteoporosis. Recently, digital radiology and the internet have opened up the possibility of conducting automated opportunistic screening with DXR in post-fracture care or in combination with mammography. This study compared the performance of DXR with FRAX® and DXA in discriminating major osteoporotic fracture (MOF) (hip, clinical spine, forearm or shoulder), hip fracture and femoral neck osteoporosis. This prospective cohort study was conducted on 5278 women 65years and older in the Study of Osteoporotic Fractures (SOF) cohort. Baseline hand X-ray images were analyzed and fractures were ascertained during 10years of follow up. Age-adjusted area under receiver operating characteristic curve (AUC) for MOF and hip fracture and for femoral neck osteoporosis (DXA FN BMD T-score ≤-2.5) was used to compare the methods. Sensitivity to femoral neck osteoporosis at equal selection rates was tabulated for FRAX and DXR. DXR-BMD, FRAX (no BMD) and lumbar spine DXA BMD were all similar in fracture discriminative performance with an AUC around 0.65 for MOF and 0.70 for hip fractures for all three methods. As expected femoral neck DXA provided fracture discrimination superior both to other BMD measurements and to FRAX. AUC for selection of patients with femoral neck osteoporosis was higher with DXR-BMD, 0.76 (0.74-0.77), than with FRAX, 0.69 (0.67-0.71), (p<0.0001). In conclusion, DXR-BMD discriminates incident fractures to a similar degree as FRAX and predicts femoral neck osteoporosis to a larger degree than FRAX. DXR shows promise as a method to automatically flag individuals who might benefit from an osteoporosis assessment.
authors.affiliation: Radiology, Department of Medicine and Health Sciences, Faculty of Health Sciences, Linköping University, Östergötland County Council, University hospital, Linköping, Sweden; Center for Medical Image Science and Visualization zCMIV), Linköping University, Sweden; Sectra AB, Linköping, Sweden. Electronic address: johan.kalvesten@gmail.com.
authors.forename: Johan
authors.initials: J
authors.lastname: Kälvesten
authors.affiliation: San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA, USA.
authors.forename: Li-Yung
authors.initials: LY
authors.lastname: Lui
authors.affiliation: Karolinska Institutet, Department for Clinical Science, Intervention and Technology, Division of Radiology, Karolinska University Hospital, Sweden.
authors.forename: Torkel
authors.initials: T
authors.lastname: Brismar
authors.affiliation: San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Cummings
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D015519:Bone Density; D005260:Female; D005500:Follow-Up Studies; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D015994:Incidence; D058866:Osteoporotic Fractures / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology; D011856:Radiographic Image Enhancement; D018570:Risk Assessment
keywords: Bone mineral density; Digital X-ray radiogrammetry; Dual-energy X-ray absorptiometry; FRAX; Osteoporosis