title: Polymeric near-infrared absorbing dendritic nanogels for efficient in vivo photothermal cancer therapy.
abstract: In recent years, several near-infrared light absorbing inorganic nanomaterials have been developed for photothermal therapy. However, their biological fate after injection limits their clinical utilization. In this work, we developed a novel polymeric near-infrared light absorbing material based on a biocompatible thermoresponsive nanogel that is semi-interpenetrated with polyaniline, a conjugated polymer with strong near-infrared absorbance. This polymeric nanocomposite generates heat after being irradiated by NIR light, thereby inducing a local hyperthermia that is used for photothermal cancer therapy in vitro and in vivo.
authors.affiliation: Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany. marcelo.calderon@fu-berlin.de.
authors.forename: Maria
authors.initials: M
authors.lastname: Molina
authors.affiliation: Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany. marcelo.calderon@fu-berlin.de.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Wedepohl
authors.affiliation: Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany. marcelo.calderon@fu-berlin.de.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Calderón
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002460:Cell Line; D045744:Cell Line, Tumor; D003432:Cross-Linking Reagents / Q000737:chemistry; D005260:Female; D005782:Gels / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007259:Infrared Rays; D008027:Light; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D000080385:Nanogels; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012542:Scattering, Radiation; D019265:Spectroscopy, Near-Infrared; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D000814:Aniline Compounds; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D005782:Gels; D000080385:Nanogels; D011108:Polymers; C416807:polyaniline; C413692:polyethylene glycol polyethyleneimine nanogel; C052970:poly-N-isopropylacrylamide; D011092:Polyethylene Glycols; D011094:Polyethyleneimine