title: [Construction and analysis of a breast cancer gene-drug network model].
abstract: OBJECTIVE
  To construct a breast cancer gene-drug network model for extracting and predicting the correlations between breast cancer-related genes and drugs.
  
  
  METHODS
  We developed an algorithm based on the ABC principle and the association rules to obtain the correlations between the biological entities. For breast cancer, we constructed 3 different correlations (gene-gene, drug-drug and gene-drug) and used the R language to implement the associated network model. The reliability of the algorithm was verified by ROC curve.
  
  
  RESULTS
  We identified 185 breast cancer-associated genes and 98 associations between them, 97 drugs and 170 associations between them. The breast cancer genes-drugs network contained 127 genes and 77 drugs with 384 associations between them.
  
  
  CONCLUSIONS
  We identified a large number of different correlations between the breast cancer-related genes and drugs and close correlations between some biological entity pairs that have not yet been reported, which may provide a new strategy for experimental design for testing personalized breast cancer treatment.
authors.affiliation: 1Instituteof Information Security and Big Data, 2School of Public Health,Central South University, Changsha 410083, China; 3Department of Public Courses, Bengbu Medical College, Bengbu 233003, China. E-mail: weixing911119@163.com.
authors.forename: Xing
authors.initials: X
authors.lastname: Wei
authors.forename: De-Hua
authors.initials: DH
authors.lastname: Hu
authors.forename: Min-Han
authors.initials: MH
authors.lastname: Yi
authors.forename: Xue-Lian
authors.initials: XL
authors.lastname: Chang
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Zhu
authors.forename: Shao-Ling
authors.initials: SL
authors.lastname: Qu
authors.forename: Duan-Ying
authors.initials: DY
authors.lastname: Deng
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D053263:Gene Regulatory Networks; D052138:Genes, Neoplasm; D006801:Humans; D012372:ROC Curve; D015203:Reproducibility of Results
chemical_list: D000970:Antineoplastic Agents