title: Add-on effects of a low-dose aripiprazole in resolving hyperprolactinemia induced by risperidone or paliperidone.
abstract: This study investigated the effects of a low-dose aripiprazole adjunctive treatment for risperidone- or paliperidone-induced hyperprolactinemia in Han Chinese women with schizophrenia. After 4 weeks of risperidone or paliperidone treatment, 60 out of 66 patients improved significantly and experienced hyperprolactinemia. They were randomly assigned to the treatment group (aripiprazole adjunctive treatment) (n=30) or control group (non-adjunctive treatment) (n=30). The dosage of risperidone and paliperidone were maintained; and aripiprazole was maintained at 5mg/day during the 8-week study period. The prolactin levels at the end of the 8th week were significantly lower in the treatment group than in the control group. The estradiol level correlated negatively with serum prolactin level both in the treatment group and the control group at the end of the 8th week and the 4th week respectively. The Positive and Negative Syndrome Scale score improved significantly during the 8-week study period in both groups. The incidence of treatment-emergent adverse event was similar in two groups. Low-dose aripiprazole adjunctive treatment is effective in relieving risperidone- and paliperidone-induced hyperprolactinemia in female schizophrenic patients without increasing adverse event.
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Fuzhong
authors.initials: F
authors.lastname: Yang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 South Wan Ping Road, Shanghai 200030, China. Electronic address: chunbo_li@163.com.
authors.forename: Chunbo
authors.initials: C
authors.lastname: Li
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wen
authors.affiliation: Department of Psychiatry, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai 200040, China.
authors.forename: Suoyu
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Peking University Health Science Center, No. 38 Xueyuan Road, Beijing 100191, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Ouyang
authors.affiliation: Shanghai Jiao Tong University School of Medicine, No. 227 South Chongqing Road, Shanghai 200030, China.
authors.forename: Weidi
authors.initials: W
authors.lastname: Shen
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 South Wan Ping Road, Shanghai 200030, China. Electronic address: sjh-lyl@263.net.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Sheng
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000068180:Aripiprazole / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008875:Middle Aged; D000068882:Paliperidone Palmitate / Q000009:adverse effects* / Q000627:therapeutic use; D011388:Prolactin / Q000097:blood; D018967:Risperidone / Q000009:adverse effects* / Q000627:therapeutic use; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D004958:Estradiol; D000068180:Aripiprazole; D011388:Prolactin; D018967:Risperidone; D000068882:Paliperidone Palmitate
keywords: Aripiprazole; Paliperidone; Prolactin; Randomized controlled study; Risperidone; Schizophrenia