title: Coordinated expansion of both memory T cells and NK cells in response to CMV infection in humans.
abstract: NK cells are key players in the fight against persistent viruses. Human cytomegalovirus (HCMV) infection is associated with the presence of a population of CD16(+) CD56(dim) NKG2C(+) NK cells in both acutely and latently infected individuals. Here, we studied the nature of these terminally differentiated NK cells in different human populations infected with HCMV: healthy donors stratified by age, thymectomized individuals, pregnant women suffering from primary CMV infection, and lung transplant patients. Both CD16(+) CD56(dim) NK- and CD8 T-cell phenotypes as well as functional capacities were determined and stratified according to age and/or CMV event. Similarly to T-cell responsiveness, we observe an accumulation over time of NKG2C(+) NK cells, which preferentially expressed CD57. This accumulation is particularly prominent in elderly and amplified further by CMV infection. Latent HCMV infection (without replication) is sufficient for NKG2C(+) CD57(+) NK cells to persist in healthy individuals but is not necessarily required in old age. Collectively, the present work supports the emerging concept that CMV shapes both innate and adaptive immunity in humans.
authors.affiliation: Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Universités, DHU FAST, CR7, UPMC Univ Paris 06, Paris, France.|INSERM, U1135, CIMI-Paris, Paris, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Bayard
authors.affiliation: Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Universités, DHU FAST, CR7, UPMC Univ Paris 06, Paris, France.|INSERM, U1135, CIMI-Paris, Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Lepetitcorps
authors.affiliation: Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Universités, DHU FAST, CR7, UPMC Univ Paris 06, Paris, France.|INSERM, U1135, CIMI-Paris, Paris, France.|AP-HP, Service de pneumologie, Hôpital Foch, Suresnes, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Roux
authors.affiliation: Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Universités, DHU FAST, CR7, UPMC Univ Paris 06, Paris, France.|INSERM, U1135, CIMI-Paris, Paris, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Larsen
authors.affiliation: Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Universités, DHU FAST, CR7, UPMC Univ Paris 06, Paris, France.|INSERM, U1135, CIMI-Paris, Paris, France.
authors.forename: Solène
authors.initials: S
authors.lastname: Fastenackels
authors.affiliation: AP-HP, Unité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique/ M3C, Hôpital Necker enfants malades, Paris, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Salle
authors.affiliation: Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Universités, DHU FAST, CR7, UPMC Univ Paris 06, Paris, France.|INSERM, U1135, CIMI-Paris, Paris, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Vieillard
authors.affiliation: Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi, Belgium.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Marchant
authors.affiliation: AP-HP, Service de pneumologie, Hôpital Foch, Suresnes, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Stern
authors.affiliation: AP-HP, Service de gériatrie, Hôpital Pitié-Salpêtrière, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Boddaert
authors.affiliation: AP-HP, Unité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique/ M3C, Hôpital Necker enfants malades, Paris, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Bajolle
authors.affiliation: Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Universités, DHU FAST, CR7, UPMC Univ Paris 06, Paris, France.|INSERM, U1135, CIMI-Paris, Paris, France.
authors.forename: Victor
authors.initials: V
authors.lastname: Appay
authors.affiliation: Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Universités, DHU FAST, CR7, UPMC Univ Paris 06, Paris, France.|INSERM, U1135, CIMI-Paris, Paris, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Sauce
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology; D018959:CD57 Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000502:physiology; D003587:Cytomegalovirus / Q000276:immunology* / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000821:virology; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007156:Immunologic Memory; D007694:Killer Cells, Natural / Q000276:immunology* / Q000502:physiology*; D016040:Lung Transplantation; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology; D017735:Virus Latency; D055815:Young Adult
chemical_list: D018959:CD57 Antigens
keywords: Aging ⋅ Human ⋅ NK cells ⋅ T lymphocytes ⋅ Viral infection