title: Total Synthesis of Native 5,7-Diacetylpseudaminic Acid from N-Acetylneuraminic Acid.
abstract: The pseudaminic acids are a family of 5,7-diamino-3,5,7,9-tetradeoxynonulosonic acids that are functional components of flagellin and pili proteins within clinically relevant Gram-negative bacteria. Herein, we describe the total synthesis of the most common pseudaminic acid, 5,7-diacetylpseudaminic acid, from N-acetylneuraminic acid. The divergent nature of the route reported here provides a robust and versatile means to access other members of the family, together with analogues, for probing the functional role of the pseudaminic acids and pseudaminic acid derived proteins in the future.
authors.affiliation: School of Chemistry, The University of Sydney , Sydney, NSW, 2006, Australia.
authors.forename: James T
authors.initials: JT
authors.lastname: Williams
authors.affiliation: School of Chemistry, The University of Sydney , Sydney, NSW, 2006, Australia.
authors.forename: Leo
authors.initials: L
authors.lastname: Corcilius
authors.affiliation: Institute for Glycomics, Griffith University Gold Coast Campus , Southport, QLD, 4222, Australia.
authors.forename: Milton J
authors.initials: MJ
authors.lastname: Kiefel
authors.affiliation: School of Chemistry, The University of Sydney , Sydney, NSW, 2006, Australia.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Payne
mesh_terms: D036781:Fimbriae Proteins / Q000737:chemistry*; D005408:Flagellin / Q000737:chemistry*; D006031:Glycosylation; D006090:Gram-Negative Bacteria / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*; D013400:Sugar Acids / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: C513444:5,7-diacetamido-3,5,7,9-tetradeoxynonulosonic acid; C000610870:5,7-diacetylpseudaminic acid; D013400:Sugar Acids; D005408:Flagellin; D036781:Fimbriae Proteins; D019158:N-Acetylneuraminic Acid