title: MYC-induced nuclear antigen (MINA) and preeclampsia.
abstract: BACKGROUND
  Inadequate trophoblast invasion and the subsequent inflammatory response have been implicated in preeclampsia (PE) pathogenesis. Because MYC-induced nuclear antigen (MINA) gene expression is involved in cell proliferation and differentiation, inflammatory response modulation, and the unpaired regulation of which is associated with human diseases, we sought to investigate the connection between MINA and PE.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the possible relationship between the MINA rs4857304 variant and susceptibility to PE development as well as to estimate placental MINA gene expression and its association with PE.
  
  
  METHODS
  About 242 pregnant women (126 PE cases and 116 controls) were included. MINA genotyping and gene expression were evaluated by quantitative real-time polymerase chain reaction using TaqMan probes.
  
  
  RESULTS
  The G/G genotype of the MINA rs4857304 variant was associated with severe PE (p = 0.027, OR = 1.8, 95% CI = 1.8-3.2). Carriers of one G allele of the MINA rs4857304 variant exhibited a 1.7-fold increased risk of severe PE (p = 0.029, 95% CI = 1.1-3.0). MINA was underexpressed in preeclamptic placentas and MINA expression differed between the mild and severe PE groups. Differences in the expression levels of MINA were found among women with the T/T genotype of the rs4857304 polymorphism and carriers of at least one G allele (p = 0.024).
  
  
  CONCLUSIONS
  PE and its severity are associated with the underexpression of placental MINA, and the G/G genotype of the MINA rs4857304 variant may modify the risk of severe PE among the PE cases evaluated.
authors.affiliation: a Molecular Medicine Laboratory , Unidad Académica de Medicina Humana y Ciencias de la Salud , Zacatecas , México.
authors.forename: Margarita L
authors.initials: ML
authors.lastname: Martinez-Fierro
authors.affiliation: a Molecular Medicine Laboratory , Unidad Académica de Medicina Humana y Ciencias de la Salud , Zacatecas , México.
authors.forename: Edwin A
authors.initials: EA
authors.lastname: Reyes-Oliva
authors.affiliation: a Molecular Medicine Laboratory , Unidad Académica de Medicina Humana y Ciencias de la Salud , Zacatecas , México.
authors.forename: Griselda A
authors.initials: GA
authors.lastname: Cabral-Pacheco
authors.affiliation: a Molecular Medicine Laboratory , Unidad Académica de Medicina Humana y Ciencias de la Salud , Zacatecas , México.
authors.forename: Idalia
authors.initials: I
authors.lastname: Garza-Veloz
authors.affiliation: b Biomedical Research Laboratory , Unidad Académica de Odontología , Zacatecas , México.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Aceves-Medina
authors.affiliation: c Miltenyi Biotec GmbH , Bergisch Gladbach , Germany.
authors.forename: Martha
authors.initials: M
authors.lastname: Luevano
authors.affiliation: d Laboratory of Cell and Molecular Biology , Unidad Académica de Ciencias Químicas , Zacatecas , México.
authors.forename: Olga Y
authors.initials: OY
authors.lastname: Barbosa-Cisneros
authors.affiliation: e Laboratory of Neurobiology , Unidad Académica de Ciencias Químicas , Zacatecas , México.
authors.forename: Marisol
authors.initials: M
authors.lastname: Galvan-Valencia
authors.affiliation: a Molecular Medicine Laboratory , Unidad Académica de Medicina Humana y Ciencias de la Salud , Zacatecas , México.
authors.forename: Patricia
authors.initials: P
authors.lastname: Yahuaca-Mendoza
authors.affiliation: f School of Medicine , University of Colima , Colima , Mexico.|g Instituto Estatal de Cancerología , Servicios de Salud del Estado de Colima , Colima , México.
authors.forename: Ivan
authors.initials: I
authors.lastname: Delgado-Enciso
authors.affiliation: h Department of Genetics , School of Medicine, Universidad Autonoma de Nuevo Leon , Monterrey , Mexico.
authors.forename: Michelle
authors.initials: M
authors.lastname: Zamudio-Osuna
authors.affiliation: h Department of Genetics , School of Medicine, Universidad Autonoma de Nuevo Leon , Monterrey , Mexico.
authors.forename: Iram P
authors.initials: IP
authors.lastname: Rodriguez-Sanchez
authors.affiliation: i Hospital de la Mujer Zacatecana, Servicios de Salud de Zacatecas, Zona Industrial , Zacatecas , Mexico.
authors.forename: Rosbel
authors.initials: R
authors.lastname: Vazquez-Castro
authors.affiliation: a Molecular Medicine Laboratory , Unidad Académica de Medicina Humana y Ciencias de la Salud , Zacatecas , México.
authors.forename: Marycruz
authors.initials: M
authors.lastname: Guerrero-Saucedo
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D049308:Dioxygenases; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D056466:Histone Demethylases; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D009687:Nuclear Proteins; D049308:Dioxygenases; D056466:Histone Demethylases; C466777:RIOX2 protein, human
keywords: Biomarkers; c-Myc; placental tissue; preeclampsia