title: Imaging the Neocortex Functional Architecture Using Multiple Intrinsic Signals: Implications for Hemodynamic-Based Functional Imaging.
abstract: Optical imaging based on intrinsic signals has provided a new level of understanding of the principles underlying cortical development, organization, and function, providing a spatial resolution of up to 20 µm for mapping cortical columns in vivo. This introduction briefly reviews the development of this technique, the types of applications that have been pursued, and the general implications of some findings for other neuroimaging techniques based on hemodynamic responses (e.g., functional magnetic resonance imaging).
authors.forename: Amiram
authors.initials: A
authors.lastname: Grinvald
authors.forename: Dahlia
authors.initials: D
authors.lastname: Sharon
authors.forename: David
authors.initials: D
authors.lastname: Omer
authors.forename: Ivo
authors.initials: I
authors.lastname: Vanzetta
mesh_terms: D000818:Animals; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D008322:Mammals; D019579:Neocortex / Q000033:anatomy & histology* / Q000502:physiology*; D000069336:Neurovascular Coupling; D061848:Optical Imaging / Q000379:methods*