title: Multimodality Raman and photoacoustic imaging of surface-enhanced-Raman-scattering-targeted tumor cells.
abstract: A multimodality Raman and photoacoustic imaging system is presented. This system has ultralow background and can detect tumor cells labeled with modified surface-enhanced-Raman-scattering (SERS) nanoparticles in vivo. Photoacoustic imaging provides microvascular context and can potentially be used to guide magnetic trapping of circulating tumor cells for SERS detection in animal models.
authors.affiliation: University of Alberta, Department of Electrical and Computer Engineering, Second Floor ECERF, 9107-116 Street, Edmonton, Alberta, T6G 2V4, Canada.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.affiliation: University of Alberta, Department of Electrical and Computer Engineering, Second Floor ECERF, 9107-116 Street, Edmonton, Alberta, T6G 2V4, CanadabUniversity of Alberta, Department of Oncology, 114 Street and 87 Avenue, Edmonton, Alberta, T6G 2E1, Canada.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Paproski
authors.affiliation: University of Alberta, Department of Electrical and Computer Engineering, Second Floor ECERF, 9107-116 Street, Edmonton, Alberta, T6G 2V4, Canada.
authors.forename: Peng
authors.initials: P
authors.lastname: Shao
authors.affiliation: University of Alberta, Department of Electrical and Computer Engineering, Second Floor ECERF, 9107-116 Street, Edmonton, Alberta, T6G 2V4, Canada.
authors.forename: Alexander
authors.initials: A
authors.lastname: Forbrich
authors.affiliation: University of Alberta, Department of Oncology, 114 Street and 87 Avenue, Edmonton, Alberta, T6G 2E1, Canada.
authors.forename: John D
authors.initials: JD
authors.lastname: Lewis
authors.affiliation: University of Alberta, Department of Electrical and Computer Engineering, Second Floor ECERF, 9107-116 Street, Edmonton, Alberta, T6G 2V4, Canada.
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Zemp
mesh_terms: D000818:Animals; D004867:Equipment Design; D006367:HeLa Cells; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D064847:Multimodal Imaging / Q000379:methods*; D009360:Neoplastic Cells, Circulating / Q000737:chemistry*; D019047:Phantoms, Imaging; D051381:Rats; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D058185:Magnetite Nanoparticles