title: Chondral and osteochondral operative treatment in early osteoarthritis.
abstract: In recent years treatment of early osteoarthritis came more and more into focus of orthopaedic research. In particular regenerative therapy options seem to have a high potential to fill the existing treatment gap for patients with early osteoarthritic changes. This article focuses on basic science, recent developments and available clinical data in the important field of operative regeneration procedures for treatment of chondral and osteochondral defects in early degenerative joints. It highlights current knowledge and perspectives of treatment options like microfracture, autologous or allogenous osteochondral transplantations and autologous chondrocyte transplantation. Further the role of biomaterials in a degenerative joint environment is illuminated. First clinical data of regenerative therapy in early osteoarthritis are encouraging to intensify research efforts in this important field. Future treatment perspectives for patients who suffer from early degenerative cartilage changes are discussed.
authors.affiliation: Department of Trauma Surgery, University Medical Center of Regensburg, Franz-Josef Strauss Allee 11, 93042, Regensburg, Germany. peter.angele@ukr.de.|Sporthopaedicum Regensburg, Hildegard von Bingen Strasse 1, 93053, Regensburg, Germany. peter.angele@ukr.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Angele
authors.affiliation: Department of Orthopedic Surgery and Traumatology, Freiburg University Hospital, Hugstetter Strasse 55, 79106, Freiburg, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Niemeyer
authors.affiliation: SportClinic Zurich, Hirslandenklinik, Witellikerstrasse 40, 8032, Zurich, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Steinwachs
authors.affiliation: Biomechanics Laboratory, II Orthopaedics and Traumatology Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano, 1/10, 40136, Bologna, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Filardo
authors.affiliation: Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Gomoll
authors.affiliation: Biomechanics Laboratory, II Orthopaedics and Traumatology Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano, 1/10, 40136, Bologna, Italy.
authors.forename: Elizaveta
authors.initials: E
authors.lastname: Kon
authors.affiliation: Department of Trauma Surgery, University Medical Center of Regensburg, Franz-Josef Strauss Allee 11, 93042, Regensburg, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Zellner
authors.affiliation: Center of Experimental Orthopaedics, Saarland University, Homburg/Saar, Germany.|Department of Orthopaedic Surgery, Saarland University Medical Center, Kirrberger Strasse 100, Building 37-38, 66421, Homburg/Saar, Germany.
authors.forename: Henning
authors.initials: H
authors.lastname: Madry
mesh_terms: D002356:Cartilage; D002358:Cartilage, Articular / Q000502:physiology / Q000601:surgery*; D019902:Chondrocytes / Q000637:transplantation*; D006801:Humans; D010003:Osteoarthritis / Q000601:surgery*; D012038:Regeneration; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
keywords: Allografts; Autologous chondrocyte transplantation; Biomaterials; Early osteoarthritis; Microfracture; Osteochondral autografts; Regenerative cartilage treatment