title: Post-operative infection with fresh frozen allograft: reported outcomes of a hospital-based bone bank over 14 years.
abstract: Femoral head bone allografts have traditionally been used to provide mechanical stability to areas of bony deficiency, or for its osteoinductive and osteoconductive properties. Concerns have been raised over increased infection rates following the use of fresh-frozen graft tissue. This retrospective study aims to investigate the outcomes of fresh frozen femoral heads kept in a regulated, non-commercial bone bank at a university teaching hospital.The local bone bank database was used to identify released femoral heads during a 14 year study period (September 1999-December 2013) whereby a retrospective review of patient records was undertaken to determine clinical outcome. During the observed study period, 427 femoral heads were released from cold storage. Of these, 270 femoral heads had a mean follow-up of 347 days. 157 femoral heads were excluded due to insufficient follow-up data (n = 132) or discarded due to breaks in the cold chain prior to use (n = 25). Of the 270 included femoral heads, 231 (85.6 %) had no reported complications with good graft incorporation. In the remaining 39 with reported complications, only 5 (2.6 %) developed a postoperative infection. Our findings suggest that the use of fresh frozen allograft does not materially increase the risk of post-operative bacterial infection. Our reported post-operative infection rates are comparable with infection rates of other similar studies on fresh frozen allograft use.
authors.affiliation: The Royal Gwent Hospital, Lovely Lane, Newport, NP20 2UB, UK. wingyum@gmail.com.
authors.forename: Wing Yum
authors.initials: WY
authors.lastname: Man
authors.affiliation: The Royal Gwent Hospital, Lovely Lane, Newport, NP20 2UB, UK.
authors.forename: Toni
authors.initials: T
authors.lastname: Monni
authors.affiliation: The Royal Gwent Hospital, Lovely Lane, Newport, NP20 2UB, UK.
authors.forename: Ruth
authors.initials: R
authors.lastname: Jenkins
authors.affiliation: The Royal Gwent Hospital, Lovely Lane, Newport, NP20 2UB, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Roberts
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D064591:Allografts / Q000637:transplantation*; D018586:Bone Banks; D016025:Bone Transplantation / Q000009:adverse effects*; D015925:Cryopreservation; D005260:Female; D005270:Femur Head / Q000637:transplantation; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology* / Q000382:microbiology*; D016896:Treatment Outcome
keywords: Femoral head allograft; Fresh frozen allograft; Infection