title: Temporal Trend in Androgen Status and Androgen-Sensitive Outcomes in Older Men.
abstract: Although androgen status decreases with aging in unselected men, the contemporaneous relationship over time between circulating hormones and androgen-sensitive outcomes has not been reported.
  
  
  
  To investigate the temporal relationships between age-specific androgen status and muscle (mass, strength), hemoglobin, and prostate-specific antigen (PSA).
  
  
  
  Men aged 70 years and older from the Concord Health and Ageing in Men Project study were assessed at baseline (2005–2007; n = 1705) and at 2-year (n = 1367) and 5-year follow-up (n = 958).
  
  
  
  At all assessments, serum T, dihydrotestosterone (DHT), estradiol (E2), and estrone (E1) were measured by liquid chromatography-tandem mass spectrometry, and serum SHBG, LH, and FSH were measured by immunoassay together with calculation of free T (cFT). Muscle mass, strength of upper (hand grip) and lower (walking speed) limbs, hemoglobin, and prostate size (serum PSA) were measured.
  
  
  
  Serum hormones showed longitudinal, within-man decreases in serum T (−2.6%/y), DHT (−2.6%/y), E1 (−3.2%/y), and cFT (−2.8%/y) but increases in serum E2 (2.6%/y), SHBG (1.3%/y), LH (1.9%/y), and FSH (1.8%/y). Significant positive correlation was observed between changes in serum T with muscle mass, strength, and hemoglobin but not with PSA across the three time-points. Changes in serum DHT, cFT, and E1 had significant correlation with muscle mass, strength, and hemoglobin, but not with PSA.
  
  
  
  These extended observational data are consistent with the impact of reduced androgen status on some somatic features of male aging. However, they do not exclude reverse causality or independent effects of aging on both androgen status and androgen-sensitive outcomes.
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.H.S., D.J.H.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139; School of Public Health (B.H., R.G.C., V.H.), University of Sydney, Sydney, New South Wales, Australia 2006; and Centre of Education and Research on Ageing (R.G.C., V.H., F.M.B., V.N., L.M.W.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139.
authors.forename: Benjumin
authors.initials: B
authors.lastname: Hsu
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.H.S., D.J.H.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139; School of Public Health (B.H., R.G.C., V.H.), University of Sydney, Sydney, New South Wales, Australia 2006; and Centre of Education and Research on Ageing (R.G.C., V.H., F.M.B., V.N., L.M.W.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Cumming
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.H.S., D.J.H.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139; School of Public Health (B.H., R.G.C., V.H.), University of Sydney, Sydney, New South Wales, Australia 2006; and Centre of Education and Research on Ageing (R.G.C., V.H., F.M.B., V.N., L.M.W.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139.
authors.forename: Vasant
authors.initials: V
authors.lastname: Hirani
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.H.S., D.J.H.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139; School of Public Health (B.H., R.G.C., V.H.), University of Sydney, Sydney, New South Wales, Australia 2006; and Centre of Education and Research on Ageing (R.G.C., V.H., F.M.B., V.N., L.M.W.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Blyth
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.H.S., D.J.H.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139; School of Public Health (B.H., R.G.C., V.H.), University of Sydney, Sydney, New South Wales, Australia 2006; and Centre of Education and Research on Ageing (R.G.C., V.H., F.M.B., V.N., L.M.W.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139.
authors.forename: Vasi
authors.initials: V
authors.lastname: Naganathan
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.H.S., D.J.H.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139; School of Public Health (B.H., R.G.C., V.H.), University of Sydney, Sydney, New South Wales, Australia 2006; and Centre of Education and Research on Ageing (R.G.C., V.H., F.M.B., V.N., L.M.W.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139.
authors.forename: David G
authors.initials: DG
authors.lastname: Le Couteur
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.H.S., D.J.H.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139; School of Public Health (B.H., R.G.C., V.H.), University of Sydney, Sydney, New South Wales, Australia 2006; and Centre of Education and Research on Ageing (R.G.C., V.H., F.M.B., V.N., L.M.W.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139.
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Seibel
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.H.S., D.J.H.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139; School of Public Health (B.H., R.G.C., V.H.), University of Sydney, Sydney, New South Wales, Australia 2006; and Centre of Education and Research on Ageing (R.G.C., V.H., F.M.B., V.N., L.M.W.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139.
authors.forename: Louise M
authors.initials: LM
authors.lastname: Waite
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.H.S., D.J.H.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139; School of Public Health (B.H., R.G.C., V.H.), University of Sydney, Sydney, New South Wales, Australia 2006; and Centre of Education and Research on Ageing (R.G.C., V.H., F.M.B., V.N., L.M.W.), University of Sydney and Concord Hospital, Sydney, New South Wales, Australia 2139.
authors.forename: David J
authors.initials: DJ
authors.lastname: Handelsman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D013196:Dihydrotestosterone / Q000097:blood*; D004958:Estradiol / Q000097:blood; D004970:Estrone / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008137:Longitudinal Studies; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood*
chemical_list: D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; D004970:Estrone; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D017430:Prostate-Specific Antigen