title: [Role of drug transporters in the central nervous system].
abstract: Although the presence of blood-brain barrier in the mammalian organisms was discovered in the early 1900s, its precise structure and the drug transporter proteins localized in the blood-brain barrier were identified only in the last decades. Beside the ATP-binding cassette transporter proteins responsible for the protection of the brain, the Solute Carrier transporters play also an important role in the function of the central nervous system by its feeding, energy supply and cleaning function during the metabolism. This review provides an overview on the main types of transporters located in the brain, on their localization in different cell types and the main techniques for their investigation. In the second part of this article various neurodegenerative disorders and the pathology-related transporter proteins are presented. In the light of recent experimental results new therapeutic strategies may come into the focus of research for the treatment of disorders currently without effective therapy.
authors.affiliation: Információs Technológiai és Bionikai Kar, Pázmány Péter Katolikus Egyetem Budapest, Práter u. 50/A, 1083.
authors.forename: Franciska
authors.initials: F
authors.lastname: Erdő
authors.affiliation: Solvo Biotechnológiai Zrt. Budaörs.
authors.forename: Csilla
authors.initials: C
authors.lastname: Temesszentandrási-Ambrus
authors.affiliation: Solvo Biotechnológiai Zrt. Budaörs.
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Beéry
mesh_terms: D015526:AIDS Dementia Complex / Q000378:metabolism; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism*; D002493:Central Nervous System Diseases / Q000378:metabolism*; D004827:Epilepsy / Q000378:metabolism; D005909:Glioblastoma / Q000378:metabolism; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism; D020521:Stroke / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D026901:Membrane Transport Proteins
keywords: blood–brain barrier; central nervous system; központi idegrendszer; membrane transporters; membrántranszporterek; neurodegenerative diseases; neurodegeneratív betegségek; vér–agy gát