title: [Immunomodulation as innovative therapy for head and neck tumors : Current developments].
abstract: Head and neck squamous cell carcinoma (HNSCC) is characterized by its intense immune suppression and its elaborate immune escape mechanisms. Due to the fact that survival rates remain low, the role of immunotherapy has become more important and the focus of current clinical studies has shifted toward antibody-based immune checkpoint modulation. Application of immunotherapy in curative settings or for prevention of recurrent disease would be desirable.
authors.affiliation: Universitätsklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Ulm, Frauensteige 12, 89075, Ulm, Deutschland. patrick.schuler@uniklinik-ulm.de.
authors.forename: P J
authors.initials: PJ
authors.lastname: Schuler
authors.affiliation: Universitätsklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Ulm, Frauensteige 12, 89075, Ulm, Deutschland.
authors.forename: J C
authors.initials: JC
authors.lastname: Doescher
authors.affiliation: Universitätsklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Ulm, Frauensteige 12, 89075, Ulm, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Laban
authors.affiliation: Universitätsklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Ulm, Frauensteige 12, 89075, Ulm, Deutschland.
authors.forename: T K
authors.initials: TK
authors.lastname: Hoffmann
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D019496:Cancer Vaccines / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000276:immunology*; D019317:Evidence-Based Medicine; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods / Q000639:trends*; D000077195:Squamous Cell Carcinoma of Head and Neck; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D019496:Cancer Vaccines; D007155:Immunologic Factors
keywords: Head and neck neoplasms; Immunotherapy; Monoclonal antibodies; Programmed cell death 1 receptor; Vaccination