title: Sofosbuvir and Simeprevir Treatment of a Stem Cell Transplanted Teenager With Chronic Hepatitis C Infection.
abstract: There have been no previous reports on the use of interferon-free combinations in pediatric patients with chronic hepatitis C infection. An infected adolescent with severe sickle cell disease underwent stem cell transplantation and subsequent treatment with sofosbuvir and simeprevir during ongoing immunosuppression. Despite the emergence of peripheral edema as a side effect, treatment was continued with sustained antiviral response.
authors.affiliation: From the *Division of Pediatrics, CLINTEC, Karolinska Institutet; and †Department of Pediatrics, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Björn
authors.initials: B
authors.lastname: Fischler
authors.forename: Peter
authors.initials: P
authors.lastname: Priftakis
authors.forename: Mikael
authors.initials: M
authors.lastname: Sundin
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D004487:Edema / Q000139:chemically induced; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011480:Protease Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D000069616:Simeprevir / Q000008:administration & dosage* / Q000009:adverse effects; D000069474:Sofosbuvir / Q000008:administration & dosage* / Q000009:adverse effects; D033581:Stem Cell Transplantation; D000072230:Sustained Virologic Response; D066027:Transplant Recipients
chemical_list: D000998:Antiviral Agents; D011480:Protease Inhibitors; D000069616:Simeprevir; D000069474:Sofosbuvir