title: Neural Signaling of Food Healthiness Associated with Emotion Processing.
abstract: The ability to differentiate healthy from unhealthy foods is important in order to promote good health. Food, however, may have an emotional connotation, which could be inversely related to healthiness. The neurobiological background of differentiating healthy and unhealthy food and its relations to emotion processing are not yet well understood. We addressed the neural activations, particularly considering the single subject level, when one evaluates a food item to be of a higher, compared to a lower grade of healthiness with a particular view on emotion processing brain regions. Thirty-seven healthy subjects underwent functional magnetic resonance imaging while evaluating the healthiness of food presented as photographs with a subsequent rating on a visual analog scale. We compared individual evaluations of high and low healthiness of food items and also considered gender differences. We found increased activation when food was evaluated to be healthy in the left dorsolateral prefrontal cortex and precuneus in whole brain analyses. In ROI analyses, perceived and rated higher healthiness was associated with lower amygdala activity and higher ventral striatal and orbitofrontal cortex activity. Females exerted a higher activation in midbrain areas when rating food items as being healthy. Our results underline the close relationship between food and emotion processing, which makes sense considering evolutionary aspects. Actively evaluating and deciding whether food is healthy is accompanied by neural signaling associated with reward and self-relevance, which could promote salutary nutrition behavior. The involved brain regions may be amenable to mechanisms of emotion regulation in the context of psychotherapeutic regulation of food intake.
authors.affiliation: Clinic for Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry in ZürichZürich, Switzerland; Department of Consumer Behaviour, Institute for Environmental Decisions, ETH ZürichZürich, Switzerland.
authors.forename: Uwe
authors.initials: U
authors.lastname: Herwig
authors.affiliation: Department of Consumer Behaviour, Institute for Environmental Decisions, ETH Zürich Zürich, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Dhum
authors.affiliation: Clinic for Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry in Zürich Zürich, Switzerland.
authors.forename: Anna
authors.initials: A
authors.lastname: Hittmeyer
authors.affiliation: Clinic for Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry in Zürich Zürich, Switzerland.
authors.forename: Sarah
authors.initials: S
authors.lastname: Opialla
authors.affiliation: Clinic for Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry in Zürich Zürich, Switzerland.
authors.forename: Sigrid
authors.initials: S
authors.lastname: Scherpiet
authors.affiliation: Department of Consumer Behaviour, Institute for Environmental Decisions, ETH Zürich Zürich, Switzerland.
authors.forename: Carmen
authors.initials: C
authors.lastname: Keller
authors.affiliation: Clinic for Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry in ZürichZürich, Switzerland; Department of Consumer Behaviour, Institute for Environmental Decisions, ETH ZürichZürich, Switzerland.
authors.forename: Annette B
authors.initials: AB
authors.lastname: Brühl
authors.affiliation: Department of Consumer Behaviour, Institute for Environmental Decisions, ETH Zürich Zürich, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Siegrist
keywords: amygdala; food; functional neuroimaging; gender; healthiness; midbrain