title: Synthesis of 2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate and a photocaged analogue.
abstract: Diphosphoinositol polyphosphates (inositol pyrophosphates, X-InsP7) are a family of second messengers with important roles in eukaryotic biology. Their chemical synthesis and modification remains a challenging task due to the high density of phosphate groups arranged around the myo-inositol core. Here, a novel approach is presented that facilitates the incorporation of the diphosphate in the 2-position (2-InsP7) and that enables the introduction of a photocage subunit.
authors.affiliation: Department of Chemistry, University of Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland.
authors.forename: I
authors.initials: I
authors.lastname: Pavlovic
authors.affiliation: Department of Chemistry, University of Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland.
authors.forename: D T
authors.initials: DT
authors.lastname: Thakor
authors.affiliation: Department of Chemistry and Pharmacy, Albert-Ludwigs University Freiburg, Albertstr. 21, 79104 Freiburg, Germany. Henning.Jessen@oc.uni-freiburg.de.
authors.forename: H J
authors.initials: HJ
authors.lastname: Jessen