title: Hypoxia enhances the protective effects of placenta-derived mesenchymal stem cells against scar formation through hypoxia-inducible factor-1α.
abstract: OBJECTIVE
  To explore the effect of placenta-derived mesenchymal stem cells on scar formation as well as the underlying mechanism.
  
  
  RESULTS
  The isolated placenta-derived mesenchymal stem cells from mice were distributed in the wounded areas of scalded mouse models, attenuated inflammatory responses and decreased the deposition of collagens, thus performing a beneficial effect against scar formation. Hypoxia enhanced the protective effect of placenta-derived mesenchymal stem cells and hypoxia-inducible factor-1α was involved in the protective effect of placenta-derived mesenchymal stem cells in hypoxic condition.
  
  
  CONCLUSIONS
  Hypoxia enhanced the protective effect of placenta-derived mesenchymal stem cells through hypoxia-inducible factor-1α and PMSCs may have a potential application in the treatment of wound.
authors.affiliation: Department of Pathophysiology, College of Basic Medical Science, China Medical University, 77 Puhe Road, Shenyang, 110122, People's Republic of China. dllbinglishengli@126.com.
authors.forename: Lili
authors.initials: L
authors.lastname: Du
authors.affiliation: Graduate Management Unit, The Second Military Medical University, Shanghai, 200433, People's Republic of China.|Department of Orthopedics, Changhai Hospital of The Second Military Medical University, Shanghai, 200433, People's Republic of China.
authors.forename: Runxiao
authors.initials: R
authors.lastname: Lv
authors.affiliation: Seven-Year System, Clinical Medicine, China Medical University, Shenyang, 110122, People's Republic of China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.
authors.forename: Shaohang
authors.initials: S
authors.lastname: Cheng
authors.affiliation: Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Pathophysiology, College of Basic Medical Science, China Medical University, 77 Puhe Road, Shenyang, 110122, People's Republic of China.
authors.forename: Tingxian
authors.initials: T
authors.lastname: Ma
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D002921:Cicatrix / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D003094:Collagen / Q000378:metabolism; D017077:Culture Media, Conditioned / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D007249:Inflammation / Q000517:prevention & control / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000502:physiology; D008810:Mice, Inbred C57BL; D010920:Placenta / Q000166:cytology*; D011247:Pregnancy; D014945:Wound Healing / Q000502:physiology
chemical_list: D017077:Culture Media, Conditioned; C497443:Hif1a protein, mouse; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D003094:Collagen
keywords: Collagen; Hypoxia; Hypoxia-inducible factor-1α; Inflammation; Placenta-derived mesenchymal stem cells; Scar formation