title: Evaluating serum prolactin and serum dehydroepiandrosterone sulfate levels in patients with pemphigus.
abstract: BACKGROUND
  Altered levels of sex hormones have been observed in many autoimmune disorders, but there is no considerable data about pemphigus. The aim of this study is to compare serum total and free prolactin and dehydroepiandrosterone sulfate (DHEAS) levels between patients with pemphigus and healthy controls and to determine the correlation of these hormones with disease severity.
  
  
  METHODS
  This study included 52 newly diagnosed cases of pemphigus and 57 healthy controls. Serum prolactin (total and free) and DHEAS were measured in all subjects. Data analyses were performed using JMP, Version 7.
  
  
  RESULTS
  Pemphigus patients had significantly higher levels of total and free serum prolactin (both P = 0.01) and lower levels of DHEAS (P = 0.005) than healthy controls. A significant association was found between severity of pemphigus and total prolactin levels (r = 0.40, P = 0.003).
  
  
  CONCLUSIONS
  The patients with pemphigus had higher total and free prolactin and lower DHEAS concentrations, and patients with more severe disease had higher levels of serum total prolactin. These new data may suggest a potential role for sex hormones in the pathogenesis of pemphigus disease and provide new insights for the better management of this chronic and life-threatening disease.
authors.affiliation: Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Yousefi
authors.affiliation: Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Nikoo
authors.initials: N
authors.lastname: Mozafari
authors.affiliation: Baqiatallah University of Medical Science, Tehran, Iran.
authors.forename: Mahboobeh Sadat
authors.initials: MS
authors.lastname: Hosseini
authors.affiliation: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Sharareh
authors.initials: S
authors.lastname: Gholamin
authors.affiliation: Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Seyed-Mostafa
authors.initials: SM
authors.lastname: Razavi
authors.affiliation: Shiraz University of Medical Sciences, Shiraz, Iran.|Conjoint Faculty Member, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Namazi
authors.affiliation: Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Younespour
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000097:blood*; D011388:Prolactin / Q000097:blood*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D019314:Dehydroepiandrosterone Sulfate; D011388:Prolactin