title: Pharmacokinetics of 99mTc-MAA- and 99mTc-HSA-Microspheres Used in Preradioembolization Dosimetry: Influence on the Liver-Lung Shunt.
abstract: Perfusion scintigraphy using (99m)Tc-labeled albumin aggregates is mandatory before hepatic radioembolization with (90)Y-microspheres. As part of a prospective trial, the intrahepatic and intrapulmonary stability of 2 albumin compounds, (99m)Tc-MAA (macroaggregated serum albumin [MAA]) and (99m)Tc-HSA (human serum albumin [HSA]), was assessed.
  
  
  METHODS
  In 24 patients with metastatic colorectal cancer, biodistribution (liver, lung) and liver-lung shunt (LLS) of both tracers (12 patients each) were assessed by sequential planar scintigraphy (1, 5, and 24 h after injection).
  
  
  RESULTS
  Liver uptake of both albumin compounds decreased differently. Although initial LLSs at 1 h after injection were similar in both groups, MAA-LLS increased significantly from 1 (3.9%) to 5 h (7.7%) and 24 h (9.9%) after injection, respectively. HSA-LLS did not change significantly (1 to 5 h), indicating a steady state of pulmonary and intrahepatic degradation.
  
  
  CONCLUSIONS
  Compared with (99m)Tc-MAA-microspheres, (99m)Tc-HSA-microspheres are likely more resistant to degradation over time, allowing a reliable LLS determination even at later time points.
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany oliver.grosser@med.ovgu.de.
authors.forename: Oliver S
authors.initials: OS
authors.lastname: Grosser
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Juri
authors.initials: J
authors.lastname: Ruf
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
authors.forename: Dennis
authors.initials: D
authors.lastname: Kupitz
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
authors.forename: Annette
authors.initials: A
authors.lastname: Pethe
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ulrich
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Genseke
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
authors.forename: Konrad
authors.initials: K
authors.lastname: Mohnike
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany 2nd Department of Radiology, Medical University of Gdansk, Gdansk, Poland; and.
authors.forename: Maciej
authors.initials: M
authors.lastname: Pech
authors.affiliation: Pharmtrace-Clinical Research, Berlin, Germany.
authors.forename: Wolf S
authors.initials: WS
authors.lastname: Richter
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Ricke
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Amthauer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000528:radiation effects; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000532:radiotherapy / Q000556:secondary; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D055420:Perfusion Imaging; D011446:Prospective Studies; D013668:Technetium Tc 99m Aggregated Albumin / Q000737:chemistry* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin
keywords: 99mTc-labeled albumin spheres; biokinetics; dosimetry; liver-lung shunt; radioembolization