title: The Ecology and Evolutionary Dynamics of Meiotic Drive.
abstract: Meiotic drivers are genetic variants that selfishly manipulate the production of gametes to increase their own rate of transmission, often to the detriment of the rest of the genome and the individual that carries them. This genomic conflict potentially occurs whenever a diploid organism produces a haploid stage, and can have profound evolutionary impacts on gametogenesis, fertility, individual behaviour, mating system, population survival, and reproductive isolation. Multiple research teams are developing artificial drive systems for pest control, utilising the transmission advantage of drive to alter or exterminate target species. Here, we review current knowledge of how natural drive systems function, how drivers spread through natural populations, and the factors that limit their invasion.
authors.affiliation: Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland. Electronic address: anna.lindholm@ieu.uzh.ch.
authors.forename: Anna K
authors.initials: AK
authors.lastname: Lindholm
authors.affiliation: Department of Genetics, University of Georgia, Athens, GA 30602, USA.
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Dyer
authors.affiliation: Centre for Evolutionary Biology, School of Animal Biology, University of Western Australia, Perth, Western Australia 6009, Australia.
authors.forename: Renée C
authors.initials: RC
authors.lastname: Firman
authors.affiliation: Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA.
authors.forename: Lila
authors.initials: L
authors.lastname: Fishman
authors.affiliation: Department of Behavioural Ecology and Evolutionary Genetics, Max Planck Institute for Ornithology, 82319 Seewiesen, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Forstmeier
authors.affiliation: Division of Ecology, Evolution and Genetics, Research School of Biology, Australian National University, Canberra, Australia.
authors.forename: Luke
authors.initials: L
authors.lastname: Holman
authors.affiliation: Department of Organismal Biology, Uppsala University, Norbyvägen 18D, 752 36 Uppsala, Sweden.
authors.forename: Hanna
authors.initials: H
authors.lastname: Johannesson
authors.affiliation: Department of Behavioural Ecology and Evolutionary Genetics, Max Planck Institute for Ornithology, 82319 Seewiesen, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Knief
authors.affiliation: Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Kokko
authors.affiliation: Department of Biology, University of Rochester, Rochester, NY, USA.
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Larracuente
authors.affiliation: Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.
authors.forename: Andri
authors.initials: A
authors.lastname: Manser
authors.affiliation: Évolution Génomes Comportement et Ecologie, CNRS, IRD, Univ. Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Montchamp-Moreau
authors.affiliation: Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow 119071, Russia.
authors.forename: Varos G
authors.initials: VG
authors.lastname: Petrosyan
authors.affiliation: Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Pomiankowski
authors.affiliation: Department of Biology, University of Rochester, Rochester, NY, USA.
authors.forename: Daven C
authors.initials: DC
authors.lastname: Presgraves
authors.affiliation: Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow 119071, Russia.
authors.forename: Larisa D
authors.initials: LD
authors.lastname: Safronova
authors.affiliation: Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Sutter
authors.affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Unckless
authors.affiliation: Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.
authors.forename: Rudi L
authors.initials: RL
authors.lastname: Verspoor
authors.affiliation: Biosciences, University of Exeter, Cornwall Campus, Penryn, Cornwall TR10 9FE, UK.
authors.forename: Nina
authors.initials: N
authors.lastname: Wedell
authors.affiliation: Department of Biology, University of Maryland, College Park, MD, USA.
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Wilkinson
authors.affiliation: Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.
authors.forename: Tom A R
authors.initials: TAR
authors.lastname: Price
mesh_terms: D000818:Animals; D005075:Biological Evolution; D055669:Ecological and Environmental Phenomena / Q000235:genetics*; D005260:Female; D005718:Gametogenesis / Q000235:genetics; D008297:Male; D008540:Meiosis / Q000235:genetics*; D012098:Reproduction / Q000235:genetics; D012641:Selection, Genetic
keywords: extinction; gametogenesis; gene drive; meiosis; speciation; transmission distortion