title: Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and the Association with Lipid Peroxidation: A Biomarker-Based Study between Los Angeles and Beijing.
abstract: Air pollution is among the top threats to human health in China. As air toxicants, polycyclic aromatic hydrocarbons (PAHs) could bring significant risks to population; however, the exposure to PAHs in China and its health impact are not fully understood. In 2012, a summer exchange program allowed 10 students to travel from Los Angeles to Beijing and stay there for 10 weeks. Based on the program, this study investigated the difference in urinary concentration of 12 hydroxylated-PAHs (Σ12OH-PAHs) and malondialdehyde (MDA) between the two cities. The median concentration of Σ12OH-PAHs in Beijing (14.1 μg g(-1) creatinine) was significantly higher than that in Los Angeles (5.78 μg g(-1) creatinine), indicating a higher exposure in Beijing. The ratios of homogeneous OH-PAHs (e.g., 1-/2-OH-NAP) changed significantly between the two cities (p < 0.01), which might suggest a potential alteration in metabolism subsequent to exposure. A significant association between Σ12OH-PAHs and MDA (p < 0.01) was observed, with the association varying between the two cities. This study suggests that exposure to PAHs might be linked to metabolism alteration and calls for future studies to investigate the role this possible alteration played in the health effects of PAHs exposure.
authors.affiliation: State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University , Beijing 100871, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.affiliation: State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University , Beijing 100871, P. R. China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Qiu
authors.forename: Nu
authors.initials: N
authors.lastname: Yu
authors.affiliation: State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University , Beijing 100871, P. R. China.
authors.forename: Qiaoyun
authors.initials: Q
authors.lastname: Yang
authors.forename: Jesus A
authors.initials: JA
authors.lastname: Araujo
authors.forename: Yifang
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000652:urine*; D000068476:Beijing; D015415:Biomarkers / Q000378:metabolism / Q000652:urine*; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D015141:Los Angeles; D008297:Male; D008315:Malondialdehyde / Q000652:urine; D011084:Polycyclic Aromatic Hydrocarbons / Q000652:urine*
chemical_list: D000393:Air Pollutants; D015415:Biomarkers; D011084:Polycyclic Aromatic Hydrocarbons; D008315:Malondialdehyde