title: In vitro and ex vivo antitubercular activity of diarylheptanoids from the rhizomes of Alpinia officinarum Hance.
abstract: Phytochemical investigation of methanol extract of the rhizomes of Alpinia officinarum Hance afforded four known diarylheptanoids 1,7-diphenylhept-4-en-3-one (1), 5-hydroxy-1,7-diphenyl-3-heptanone (2), 5-hydroxy-7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-3-heptanone (3), and 7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl heptan-3-one (4).The acetate derivative of (4), 7-(4″-actetate-3″-methoxy phenyl)-1-phenyl heptan-3-one (5), was prepared. These diarylheptanoids exhibited promising in vitro and ex vivo antitubercular activity for the first time against dormant Mycobacterium tuberculosis H37Ra with the IC50values between 0.34-47.69 and 0.13-22.91 μM, respectively. All compounds showed comparable activity against Mycobacterium bovis BCG (dormant phage) and did not show any activity against two gram + ve and two gram -ve bacterial strains. These compounds were also weakly cytotoxic up to 300 μM against three human cancer cell lines THP-1, Panc-1 and A549.
authors.affiliation: a Department of Chemistry, Post Graduate and Research Centre , MES Abasaheb Garware College , Pune , India.
authors.forename: Varsha S
authors.initials: VS
authors.lastname: Honmore
authors.affiliation: b R & D Centre in Pharmaceutical Sciences and Applied Chemistry, Poona College of Pharmacy , Bharati Vidyapeeth Deemed University , Pune , India.
authors.forename: Supada R
authors.initials: SR
authors.lastname: Rojatkar
authors.affiliation: c Combichem-Bioresource Centre, OCD , National Chemical Laboratory , Pune , India.
authors.forename: Laxman U
authors.initials: LU
authors.lastname: Nawale
authors.affiliation: c Combichem-Bioresource Centre, OCD , National Chemical Laboratory , Pune , India.
authors.forename: Manisha A
authors.initials: MA
authors.lastname: Arkile
authors.affiliation: c Combichem-Bioresource Centre, OCD , National Chemical Laboratory , Pune , India.
authors.forename: Vijay M
authors.initials: VM
authors.lastname: Khedkar
authors.affiliation: a Department of Chemistry, Post Graduate and Research Centre , MES Abasaheb Garware College , Pune , India.
authors.forename: Arun D
authors.initials: AD
authors.lastname: Natu
authors.affiliation: c Combichem-Bioresource Centre, OCD , National Chemical Laboratory , Pune , India.
authors.forename: Dhiman
authors.initials: D
authors.lastname: Sarkar
keywords:  Hance; antitubercular; diarylheptanoids; zingiberaceae