title: [Meta-analysis on epidemiology of iatrogenic-borne methicillin-resistant Staphylococcus aureus].
abstract: OBJECTIVE
  To study the molecular-biologic characteristics and epidemiological status of iatrogenic related Community-acquired methicillin-resistant Staphylococcus (S.) aureus (CA-MRSA) in China through Meta-analysis.
  
  
  METHODS
  Data through systematic searching for peer-reviewed articles published before December 3(rd), 2015 from 4 main electronic databases including China National Knowledge Infrastructure (CNKI), Wanfang Data, PubMed and Web of Science Core Collection was collected, for this Meta-analysis. PRISMA guidelines were followed and the proportion of MRSA, CA-MRSA, hospital-acquired MRSA (HA-MRSA) and panton-valentine leucocidin (PVL) gene in certain populations were quantitatively analyzed by Stata 13.0 software.
  
  
  RESULTS
  Average proportion of CA-MRSA from S. aureus was 12% (95%CI: 8%-16%). CA-MRSA in MRSA was 18% (95%CI: 12%-24%). 42.1% (95%CI: 20.4%-63.7%) of the CA-MRSA carried a PVL gene, and the number was higher than general MRSA (t=-2.99,P=0.011).
  
  
  CONCLUSIONS
  CA-MRSA was in lower proportion than HA-MRSA, both seen in general MRSA and in S. aureus, but under higher proportion of carrying the PVL gene. Transmission of CA-MRSA could be prevented within the general population through conducting effective surveillances and preventive programs.
authors.affiliation: Department of Epidemiology and Biostatistics, Shandong University, Jinan 250012, China.
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Zhu
authors.affiliation: Institute of Bacterial Infections Disease Control, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.
authors.forename: B L
authors.initials: BL
authors.lastname: Chen
authors.affiliation: Institute of Bacterial Infections Disease Control, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.
authors.forename: Z W
authors.initials: ZW
authors.lastname: Bi
authors.affiliation: Institute of Bacterial Infections Disease Control, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Kou
authors.affiliation: Institute of Bacterial Infections Disease Control, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.
authors.forename: B
authors.initials: B
authors.lastname: Hu
authors.affiliation: Institute of Bacterial Infections Disease Control, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.
authors.forename: M
authors.initials: M
authors.lastname: Fang
authors.affiliation: Shandong Key Laboratory of Infectious Disease Prevention and Control, Institute of Preventive Medicine, Shandong University Jinan 250012, China; Department of Epidemiology and Biostatistics, Shandong University, Jinan 250012, China; Institute of Bacterial Infections Disease Control, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Bi
mesh_terms: D001427:Bacterial Toxins / Q000302:isolation & purification; D002681:China / Q000453:epidemiology; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D016208:Databases, Factual; D005098:Exotoxins / Q000302:isolation & purification; D006801:Humans; D007049:Iatrogenic Disease / Q000453:epidemiology*; D007956:Leukocidins / Q000302:isolation & purification; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics / Q000302:isolation & purification*; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000235:genetics / Q000302:isolation & purification
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin