title: Going Germline: Mitochondrial Replacement as a Guide to Genome Editing.
abstract: Mitochondrial replacement (MR) serves as a crucial test case and learning guide for the scientific, ethical, and regulatory challenges of future reproductive breakthroughs. The lessons learned from the regulatory review process of MR over the last decade promise to enrich the emerging dialog over genome editing.
authors.affiliation: The Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.
authors.forename: Eli Y
authors.initials: EY
authors.lastname: Adashi
authors.affiliation: Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics, Harvard Law School, Cambridge, MA 02138, USA. Electronic address: igcohen@law.harvard.edu.
authors.forename: I Glenn
authors.initials: IG
authors.lastname: Cohen
mesh_terms: D005818:Genetic Engineering / Q000331:legislation & jurisprudence* / Q000379:methods*; D015316:Genetic Therapy / Q000331:legislation & jurisprudence* / Q000379:methods*; D054629:Genome, Mitochondrial; D005854:Germ Cells; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D006113:United Kingdom; D014481:United States