title: Temporal variation in the distribution of type-1 human astrovirus lineages in a settled population over 14 years.
abstract: Human astroviruses (HAstVs) are important enteric pathogens that are genetically and antigenically heterogeneous and can be classified into eight sero/genotypes (HAstV-1 to -8) and different lineages within each HAstV type. This study describes the genetic diversity of HAstVs circulating in southern Italy over 14 years. Molecular analysis of HAstV-1 strains showed that three different lineages (1a, 1b and 1d) of the predominant genotype were circulating during the study period. The study of an archival collection of HAstV strains offers a unique opportunity to evaluate the patterns of variation of HAstV infections over the years and to correlate the observed epidemiological changes to the genetic variability of HAstVs.
authors.affiliation: Department of Health Promotion Sciences and Mother and Child Care "G. D'Alessandro", University of Palermo, via del Vespro 133, 90127, Palermo, Italy. simona.degrazia@unipa.it.
authors.forename: Simona
authors.initials: S
authors.lastname: De Grazia
authors.affiliation: Department of Health Promotion Sciences and Mother and Child Care "G. D'Alessandro", University of Palermo, via del Vespro 133, 90127, Palermo, Italy.
authors.forename: Floriana
authors.initials: F
authors.lastname: Bonura
authors.affiliation: Veterinary Medical Research Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Krisztián
authors.initials: K
authors.lastname: Bányai
authors.affiliation: Agricultural Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Ákos
authors.initials: Á
authors.lastname: Gellért
authors.affiliation: Department of Health Promotion Sciences and Mother and Child Care "G. D'Alessandro", University of Palermo, via del Vespro 133, 90127, Palermo, Italy.
authors.forename: Sandra
authors.initials: S
authors.lastname: Marineo
authors.affiliation: Department of Veterinary Medicine, University Aldo Moro of Bari, Valenzano, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.affiliation: Department of Health Promotion Sciences and Mother and Child Care "G. D'Alessandro", University of Palermo, via del Vespro 133, 90127, Palermo, Italy.
authors.forename: Giovanni M
authors.initials: GM
authors.lastname: Giammanco
mesh_terms: D019350:Astroviridae Infections / Q000453:epidemiology / Q000821:virology*; D014644:Genetic Variation; D016679:Genome, Viral; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D001257:Mamastrovirus / Q000145:classification / Q000235:genetics*; D017720:Molecular Epidemiology; D016366:Open Reading Frames; D010802:Phylogeny; D013997:Time Factors