title: The Transmission and Antibiotic Resistance Variation in a Multiple Drug Resistance Clade of Vibrio cholerae Circulating in Multiple Countries in Asia.
abstract: Vibrio cholerae has caused massive outbreaks and even trans-continental epidemics. In 2008 and 2010, at least 3 remarkable cholera outbreaks occurred in Hainan, Anhui and Jiangsu provinces of China. To address the possible transmissions and the relationships to the 7th pandemic strains of those 3 outbreaks, we sequenced the whole genomes of the outbreak isolates and compared with the global isolates from the 7th pandemic. The three outbreaks in this study were caused by a cluster of V. cholerae in clade 3.B which is parallel to the clade 3.C that was transmitted from Nepal to Haiti and caused an outbreak in 2010. Pan-genome analysis provided additional evolution information on the mobile element and acquired multiple antibiotic resistance genes. We suggested that clade 3.B should be monitored because the multiple antibiotic resistant characteristics of this clade and the 'amplifier' function of China in the global transmission of current Cholera pandemic. We also show that dedicated whole genome sequencing analysis provided more information than the previous techniques and should be applied in the disease surveillance networks.
authors.affiliation: National Institute for Communicable Disease Control and Prevention, China CDC, Beijing, 102206, People's Republic of China.|State Key Laboratory of Infectious Disease Prevention and Control, Beijing, 102206, People's Republic of China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Pang
authors.affiliation: Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Du
authors.affiliation: Warwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom.
authors.forename: Zhemin
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: National Institute for Communicable Disease Control and Prevention, China CDC, Beijing, 102206, People's Republic of China.|State Key Laboratory of Infectious Disease Prevention and Control, Beijing, 102206, People's Republic of China.
authors.forename: Baowei
authors.initials: B
authors.lastname: Diao
authors.affiliation: National Institute for Communicable Disease Control and Prevention, China CDC, Beijing, 102206, People's Republic of China.|State Key Laboratory of Infectious Disease Prevention and Control, Beijing, 102206, People's Republic of China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, People's Republic of China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Cui
authors.affiliation: National Institute for Communicable Disease Control and Prevention, China CDC, Beijing, 102206, People's Republic of China.|State Key Laboratory of Infectious Disease Prevention and Control, Beijing, 102206, People's Republic of China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, People's Republic of China.
authors.forename: Haijian
authors.initials: H
authors.lastname: Zhou
authors.affiliation: National Institute for Communicable Disease Control and Prevention, China CDC, Beijing, 102206, People's Republic of China.|State Key Laboratory of Infectious Disease Prevention and Control, Beijing, 102206, People's Republic of China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, People's Republic of China.
authors.forename: Biao
authors.initials: B
authors.lastname: Kan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001208:Asia / Q000453:epidemiology; D002771:Cholera / Q000453:epidemiology / Q000382:microbiology / Q000635:transmission*; D004196:Disease Outbreaks; D004352:Drug Resistance, Microbial / Q000187:drug effects / Q000235:genetics*; D018432:Drug Resistance, Multiple / Q000187:drug effects / Q000235:genetics*; D058872:Epidemics; D014644:Genetic Variation; D016680:Genome, Bacterial / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014734:Vibrio cholerae / Q000145:classification / Q000235:genetics* / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents