title: Dietary Acrylamide and the Risk of Endometrial Cancer: An Italian Case-Control.
abstract: The role of dietary acrylamide on the risk of hormone-related, and specifically endometrial, cancers is debated. Epidemiological data are scanty. Thus, we examined the relation between acrylamide intake and endometrial cancer risk in a case-control study conducted between 1992 and 2006 in 3 Italian areas. Cases were 454 women with incident, histologically confirmed endometrial cancer. Controls were 908 age-matched women admitted to the same network of hospitals of cases for acute, non-neoplastic conditions. We calculated multivariate odds ratios (OR) and 95% confidence intervals (CI) using logistic regression models. The OR of endometrial cancer for increasing quintiles of dietary acrylamide, as compared to the lowest one, were 1.02 (95% CI: 0.67-1.54), 1.20 (95% CI: 0.80-1.80), 1.00 (95% CI: 0.65-1.54) and 1.17 (95% CI: 0.73-1.85). The OR for an increase of 10 μg/day of dietary acrylamide was 1.00 (95% CI: 0.91-1.10). In subgroup analyses, the ORs for high vs. low acrylamide intake were 1.28 (95% CI: 0.73-2.25) in never smokers and 1.14 (95% CI: 0.45-2.90) in ever smokers. Our data do not support an association between dietary acrylamide intake and endometrial cancer.
authors.affiliation: a Department of Epidemiology , IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Milan , Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Pelucchi
authors.affiliation: a Department of Epidemiology , IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Milan , Italy.
authors.forename: Carlotta
authors.initials: C
authors.lastname: Galeone
authors.affiliation: a Department of Epidemiology , IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Milan , Italy.
authors.forename: Eva
authors.initials: E
authors.lastname: Negri
authors.affiliation: a Department of Epidemiology , IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Milan , Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bosetti
authors.affiliation: b Unit of Epidemiology and Biostatistics, IRCCS - Centro di Riferimento Oncologico , Aviano , Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Serraino
authors.affiliation: c Unit of Epidemiology, Istituto Tumori "Fondazione Pascale" , Naples , Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Montella
authors.affiliation: d Unit of Epidemiology and Biostatistics, IRCCS - Centro di Riferimento Oncologico , Aviano , Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
authors.affiliation: e Department of Clinical Sciences and Community Health , University of Milan , Milan , Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
mesh_terms: D020106:Acrylamide / Q000633:toxicity*; D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004032:Diet; D016889:Endometrial Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D005260:Female; D005506:Food Contamination; D006801:Humans; D007558:Italy / Q000453:epidemiology; D016015:Logistic Models; D008875:Middle Aged; D055815:Young Adult
chemical_list: D020106:Acrylamide