title: Advances in understanding and managing atopic dermatitis.
abstract: Atopic dermatitis is a chronic, pruritic skin disease characterized by an improperly functioning skin barrier and immune dysregulation. We review proposed atopic dermatitis pathomechanisms, emphasizing how these impact current perspectives on natural history, role of allergic sensitization, and future therapeutic targets.
authors.affiliation: University of Washington School of Medicine, Seattle, WA, 98195, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Barton
authors.affiliation: Department of Pediatric Dermatology, Seattle Children's Hospital, Seattle, WA, 98105, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Sidbury
keywords: atopic; dermatitis; immune