title: Popular edible seaweed, Gelidium amansii prevents against diet-induced obesity.
abstract: The popular edible seaweed, Gelidium amansii is broadly used as food worldwide. To determine whether G. amansii extract (GAE) has protective effects on obesity, mice fed a high-fat diet (HFD) treated with GAE (1 and 3 %) were studied. After 12 weeks of GAE treatment, body weight was greatly decreased in mice fed a high-fat diet. This effect could be due to decreased adipogenesis, as evidenced by the fact that GAE suppressed adipogenic gene expression in adipocytes. In addition, blood glucose and serum insulin levels were reduced by GAE treatment in mice fed a high-fat diet, suggesting improvement in glucose metabolism. GAE supplementation also led to a significant decrease in total cholesterol and triglyceride levels. These data are further confirmed by H&E staining. Our findings indicate that Gelidium amansii prevents against the development of diet-induced obesity, and further implicate that GAE supplementation could be the therapeutical option for treatment of metabolic disorder such as obesity.
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
authors.forename: Min-Cheol
authors.initials: MC
authors.lastname: Kang
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Nalae
authors.initials: N
authors.lastname: Kang
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Seo-Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Centro de Estudos de Doenças Crónicas CEDOC, NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.
authors.forename: Inês S
authors.initials: IS
authors.lastname: Lima
authors.affiliation: Marine-Integrated Bionics Research Center, Pukyong National University, Busan 608-737, Republic of Korea; Department of Biomedical Engineering, and Center for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University, Busan 608-737, Republic of Korea.
authors.forename: Seok-Chun
authors.initials: SC
authors.lastname: Ko
authors.affiliation: Department of Food Science and Biotechnology, Kunsan National University, Gunsan 573-701, Republic of Korea.
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Kim
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
authors.forename: Young-Bum
authors.initials: YB
authors.lastname: Kim
authors.affiliation: Tidal Flat Research Center, West Sea Fisheries Research Institute, National Institute of Fisheries Science (NIFS), 11 Seollim-gill, 54014 Gunsan, Republic of Korea.
authors.forename: Hee-Do
authors.initials: HD
authors.lastname: Jeung
authors.affiliation: School of Marine Biomedical Science, Jeju National University, 102 Jejudaehakno, Jeju 690-756, Republic of Korea.
authors.forename: Kwang-Sik
authors.initials: KS
authors.lastname: Choi
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea. Electronic address: Youjinj@jejunu.ac.kr.
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Jeon
mesh_terms: D041721:3T3-L1 Cells; D052436:Adipose Tissue, White / Q000187:drug effects / Q000473:pathology; D000818:Animals; D002470:Cell Survival; D004041:Dietary Fats / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000139:chemically induced* / Q000517:prevention & control; D012624:Seaweed
chemical_list: D004041:Dietary Fats
keywords: Adipogenesis; Anti-obesity; Edible seaweed; Gelidium amansii; High fat diet