title: Corneal Biomechanical Properties in Aspirin Users.
abstract: OBJECTIVE
  To analyze corneal biomechanical properties in aspirin users using an ocular response analyzer.
  
  
  METHODS
  This study included 80 eyes of 40 aspirin users and 80 eyes of 40 individuals who did not use aspirin. Corneal hysteresis (CH), the corneal resistance factor (CRF), Goldman-correlated intraocular pressure (IOPg), and corneal compensated intraocular pressure (IOPcc) were measured in all participants. The independent samples t test was used to compare measurements in the aspirin users and nonusers in the total study population, and in the diabetic patient subgroup. Pearson's correlation analysis was used to examine the relationship between the measured variables in the aspirin users and nonusers.
  
  
  RESULTS
  Aspirin users (59.08 ± 11.83 years) were older than nonusers (39.82 ± 12.97 years; p < 0.001). The mean CH was significantly lower in the aspirin user group than in the nonuser group (p = 0.013). Mean IOPg and mean IOPcc were also significantly higher in the aspirin user group (p = 0.027 and p = 0.002, respectively). The mean CRF was lower in the aspirin user group, but not significantly (p = 0.70). There was a positive correlation between CH and CRF (r = 0.767, p < 0.001), and between CRF and IOPg (r = 0.680, p < 0.001), and a negative correlation between CH and IOPcc (r = -0.415, p < 0.001).
  
  
  CONCLUSIONS
  Aspirin should be taken into account when interpreting the results of corneal biomechanical measurements.
authors.affiliation: Department of Ophthalmology, Acibadem University School of Medicine, Istanbul, Turkey.
authors.forename: Ali Riza Cenk
authors.initials: AR
authors.lastname: Celebi
authors.forename: Ayse Ebru
authors.initials: AE
authors.lastname: Kilavuzoglu
authors.forename: Ugur Emrah
authors.initials: UE
authors.lastname: Altiparmak
authors.forename: Cemile Banu
authors.initials: CB
authors.lastname: Cosar
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D001696:Biomechanical Phenomena; D016022:Case-Control Studies; D003315:Cornea / Q000187:drug effects* / Q000502:physiology; D004548:Elasticity / Q000187:drug effects; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D014065:Tonometry, Ocular
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin