title: Incidence and prognosis of stent thrombosis following percutaneous coronary intervention in Middle Eastern patients: The First Jordanian Percutaneous Coronary Intervention Registry (JoPCR1).
abstract: BACKGROUND
  The incidence, risk factors, and outcome of stent thrombosis (ST) after percutaneous coronary intervention (PCI) in Middle Eastern patients are largely unknown.
  
  
  OBJECTIVE
  To determine the incidence, risk factors and outcome in our population.
  
  
  METHODS
  Retrospective study of a prospective multicenter registry of consecutive patients who underwent PCI between January 2013 and February 2014 (JoPCR1).
  
  
  METHODS
  12 tertiary care centers in Amman and Irbid, Jordan.
  
  
  METHODS
  We collected clinical baseline and follow-up data.
  
  
  METHODS
  Incidence of stent thrombosis.
  
  
  RESULTS
  The mean (standard deviation) age of patients (n=2426) was 59.0 (10.1) years and 20.6% were women. Stents (n=3038) were drug eluting (89.6%), bare metal (9.4%) or bioabsorbable (1.0%). After 1 year, 47 patients (1.97%) had ST, including 44 (94%) definite and 3 (6%) probable ST. Patients who had ST presented with sudden death (n=6; 12.2%) or with a nonfatal event (n=43; 87.8%). Nonfatal events included non-ST-segment elevation acute coronary syndrome (26; 53%), acute ST segment elevation myocardial infarction (n=15; 31%) or heart failure (n=2; 4.1%). ST was associated with significantly higher one-month (22.0% vs. 0.7%) and one-year (12.3% vs. 0.73%) mortality rates compared with patients who did not have ST (P < .001). ST patients were younger (mean age 52.9 years vs. 58.4 years), had heart failure (64% vs. 18%), left ventricular ejection fraction (LVEF) < 45% (36% vs. 13%), ST-segment deviation (70% vs. 48%), and elevated cardiac biomarkers blood levels (62% vs. 40%). In the multivariate analysis, the only factor that was significantly associated with ST was the heart failure (OR=3.5, 95% confidence interval: 1.8, 6.6; P < .0001).
  
  
  CONCLUSIONS
  The incidence of ST was not different from that in other regions and was associated with an increased one-year mortality. Younger age, heart failure, low LVEF, ST-segment deviation, and elevated blood levels of cardiac biomarkers were predictors of ST.
  
  
  CONCLUSIONS
  Possible selection bias, recall bias, and missing or incomplete information. The majority of patients were lost to follow up after the 6th month. The registry may not fully represent PCI practice and outcome in all areas in the country or region.
authors.affiliation: Professor Akram Abdeljaber Saleh, Jordan University Hospital,, Cardiology, Faculty of Medicine,, Amman, 1122 Jordan, T: 00962795531085, a.saleh@ju.edu.jo.
authors.forename: Akram
authors.initials: A
authors.lastname: Saleh
authors.forename: Ayman
authors.initials: A
authors.lastname: Hammoudeh
authors.forename: Ramzi
authors.initials: R
authors.lastname: Tabbalat
authors.forename: Imad
authors.initials: I
authors.lastname: Al-Haddad
authors.forename: Eyass
authors.initials: E
authors.lastname: Al-Mousa
authors.forename: Mohammad
authors.initials: M
authors.lastname: Jarrah
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Izraiq
authors.forename: Assem
authors.initials: A
authors.lastname: Nammas
authors.forename: Husham
authors.initials: H
authors.lastname: Janabi
authors.forename: Lewa
authors.initials: L
authors.lastname: Hazaymeh
authors.forename: Ali
authors.initials: A
authors.lastname: Shakhatreh
authors.forename: Youssef
authors.initials: Y
authors.lastname: Khadder
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000150:complications; D006801:Humans; D015994:Incidence; D007597:Jordan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D011183:Postoperative Complications; D011379:Prognosis; D011446:Prospective Studies; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents / Q000009:adverse effects*; D013927:Thrombosis / Q000453:epidemiology* / Q000209:etiology; D016896:Treatment Outcome