title: Glioblastoma multiforme outcomes of 107 patients treated in two Singapore institutions.
abstract: BACKGROUND
  Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults. Although the survival rate for GBM has improved with recent advancements in treatment, the prognosis remains generally poor.
  
  
  METHODS
  We conducted a retrospective review of GBM patients seen in National University Hospital, Singapore, and Tan Tock Seng Hospital, Singapore, from January 2002 to December 2011. Data on disease and treatment factors was collected and correlated with survival.
  
  
  RESULTS
  Data on a total of 107 GBM patients was analysed. Their median survival time was 15.1 months and the two-year survival rate was 23.5%, which is comparable with data published in other series. The factors associated with improved median survival time were radiotherapy dose > 50 Gy (16.1 months vs. 8.7 months, p = 0.01) and adjuvant concurrent chemotherapy (16.4 months vs. 9.2 months, p = 0.003).
  
  
  CONCLUSIONS
  GBM confers a poor prognosis. Adjuvant radiotherapy and chemotherapy are associated with improved survival. Ethnicity may be a contributing factor to differences in GBM incidence and prognosis.
authors.affiliation: Department of Radiation Oncology, National Cancer Institute Singapore, National University Health System, Singapore.
authors.forename: Song Tao Timothy
authors.initials: ST
authors.lastname: Cheo
authors.affiliation: National Registry of Diseases Office, Health Promotion Board, Singapore.
authors.forename: Gek Hsiang
authors.initials: GH
authors.lastname: Lim
authors.affiliation: Department of Radiation Oncology, National Cancer Institute Singapore, National University Health System, Singapore.|NUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Keith Hsiu Chin
authors.initials: KH
authors.lastname: Lim
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000208:ethnology / Q000628:therapy*; D005260:Female; D005909:Glioblastoma / Q000208:ethnology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012846:Singapore; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: brain tumour; clinical outcomes; glioblastoma multiforme