title: Altered neuronal activity in the pedunculopontine nucleus: An electrophysiological study in a rat model of Parkinson's disease.
abstract: The pedunculopontine nucleus (PPN) is a new deep brain stimulation target for treating Parkinson's disease (PD). But the alterations of the PPN electrophysiological activities in PD are still debated. To investigate these potential alterations, extracellular single unit and local field potential (LFP) activities in the PPN were recorded in unilateral hemispheric 6-hydroxydopamine (6-OHDA) lesioned rats and in control rats, respectively. The spike activity results revealed two types of neurons (Type I and Type II) with distinct electrophysiological characteristics in the PPN. Both types of neurons had increased firing rate and changed firing pattern in lesioned rats when compared to control rats. Specifically, Type II neurons showed an increased firing rate when the rat state was switched from rest to locomotion. The LFP results demonstrated that lesioned rats had lower LFP power at 0.7-12Hz and higher power at 12-30Hz than did control animals in either resting or locomotor state. These findings provide a better understanding of the effects of 6-OHDA lesion on neuronal activities in the PPN and also provide a proof of the link between this structure and locomotion, which contributes to better understanding the mechanisms of the PPN functioning in the pathophysiology of PD.
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Xiwen
authors.initials: X
authors.lastname: Geng
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China; Qinhuangdao Medical School, Qinhuangdao 066000, People's Republic of China.
authors.forename: Jinlu
authors.initials: J
authors.lastname: Xie
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Xuenan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Xiusong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China; Shandong College of Electronic Technology, Jinan 250200, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Yabing
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Chengdong
authors.initials: C
authors.lastname: Lei
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Qingyang
authors.initials: Q
authors.lastname: Qu
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Tingting
authors.initials: T
authors.lastname: He
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Han
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Yao
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China. Electronic address: wangmin78@yahoo.com.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D018663:Adrenergic Agents / Q000633:toxicity; D000818:Animals; D004195:Disease Models, Animal; D004558:Electric Stimulation; D008297:Male; D008474:Medial Forebrain Bundle / Q000293:injuries; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D016627:Oxidopamine / Q000633:toxicity; D010300:Parkinson Disease / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D045042:Pedunculopontine Tegmental Nucleus / Q000473:pathology*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D018663:Adrenergic Agents; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase
keywords: Dopamine; Extracellular recording; Local field potential; Parkinson’s disease; Spike; The pedunculopontine nucleus