title: Quantifying Demyelination in NK venom treated nerve using its electric circuit model.
abstract: Reduction of myelin in peripheral nerve causes critical demyelinating diseases such as chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, etc. Clinical monitoring of these diseases requires rapid and non-invasive quantification of demyelination. Here we have developed formulation of nerve conduction velocity (NCV) in terms of demyelination considering electric circuit model of a nerve having bundle of axons for its quantification from NCV measurements. This approach has been validated and demonstrated with toad nerve model treated with crude Naja kaouthia (NK) venom and also shows the effect of Phospholipase A2 and three finger neurotoxin from NK-venom on peripheral nerve. This opens future scope for non-invasive clinical measurement of demyelination.
authors.affiliation: Department of Electronics and Communication Engg., Tezpur University, Tezpur-784028, Assam, India.
authors.forename: H K
authors.initials: HK
authors.lastname: Das
authors.affiliation: Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur-784028, Assam, India.
authors.forename: D
authors.initials: D
authors.lastname: Das
authors.affiliation: Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur-784028, Assam, India.
authors.forename: R
authors.initials: R
authors.lastname: Doley
authors.affiliation: Department of Electronics and Communication Engg., Tezpur University, Tezpur-784028, Assam, India.
authors.forename: P P
authors.initials: PP
authors.lastname: Sahu
mesh_terms: D000818:Animals; D001001:Anura; D001369:Axons / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003711:Demyelinating Diseases / Q000473:pathology*; D004546:Elapid Venoms / Q000494:pharmacology*; D004560:Electricity; D007473:Ion Channels / Q000378:metabolism; D008959:Models, Neurological; D009431:Neural Conduction / Q000187:drug effects; D054467:Phospholipases A2 / Q000378:metabolism; D012584:Sciatic Nerve / Q000187:drug effects / Q000473:pathology*
chemical_list: D004546:Elapid Venoms; D007473:Ion Channels; C521753:Naja kaouthia venom; D054467:Phospholipases A2