title: Effects of 5-Pyrimidinol Derivative SNK-41 on Cytokine Profile of Mice with Lewis Lung Carcinoma.
abstract: We studied the effects of SNK-411, a new 5-pyrimidinol derivative, on serum cytokine profile of C57Bl/6 mice with Lewis lung carcinoma. The compound was injected intraperitoneally in doses of 25 and 50 mg/kg. A significant (by 3.5 times) increase in serum IL-4 content was detected in mice with tumors on day 9 of tumor development. In mice receiving SNK-411 in doses of 25 and 50 mg/kg, IL-4 content significantly decreased (by 4.0 and 3.6 times) on days 2-8 of carcinoma development; IL-2 content decreased by 1.4 and 1.2 times and IL-6 content decreased by 2.7 and 1.6 times, respectively, in comparison with control mice with tumors. Injections of SNK-411 in the same doses on days 8-15 of carcinoma development led to a significant decrease in IL-4 levels (by 2.2 and 4.5 times, respectively, in comparison with control mice with tumors) and did not affect serum levels of other cytokines.
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. olgapharm@inbox.ru.
authors.forename: O S
authors.initials: OS
authors.lastname: Kuznetsova
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Tallerova
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Nikitin
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors.forename: L P
authors.initials: LP
authors.lastname: Kovalenko
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000473:pathology; D004195:Disease Models, Animal; D007376:Interleukin-2 / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D051379:Mice; D008810:Mice, Inbred C57BL; D011743:Pyrimidines / Q000494:pharmacology*
chemical_list: C000612850:2-isobutyl-4,6-dimethyl-5-hydroxypyrimidine; D000970:Antineoplastic Agents; D007376:Interleukin-2; D015850:Interleukin-6; D011743:Pyrimidines; D015847:Interleukin-4
keywords: Lewis lung carcinoma; SNK-411; cancer immunotherapy; cytokines; interleukin-4