title: Rosuvastatin: Beyond the cholesterol-lowering effect.
abstract: Rosuvastatin is a fully synthetic statin wich acts by interfering with the endogenous synthesis of cholesterol through competitively inhibiting the 3-hydroxy-3-methylglutaryl coenzyme A reductase, a liver enzyme responsible of the rate-limiting step in cholesterol synthesis. When compared to other molecules of the same class, it shows high efficacy in the improvement of lipid profile, and, thanks to its non-cholesterol-lowering actions (anti-inflammatory, antioxidant and antithrombotic), represents a crucial tool for cardiovascular primary and secondary prevention. Moreover, recent data highlight rosuvastatin beneficial effects in several other fields. In this manuscript we analyzed literature sources in order to better define rosuvastatin features and discuss some critical issues.
authors.affiliation: Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy. Electronic address: francescacortese@hotmail.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Cortese
authors.affiliation: Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Gesualdo
authors.affiliation: Cerebrovascular Diseases and Neurorehabilitation Department, San Camillo Hospital, Venezia Lido, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Cortese
authors.affiliation: Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy.
authors.forename: Santa
authors.initials: S
authors.lastname: Carbonara
authors.affiliation: Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Devito
authors.affiliation: Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy.
authors.forename: Annapaola
authors.initials: A
authors.lastname: Zito
authors.affiliation: Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Ricci
authors.affiliation: Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Scicchitano
authors.affiliation: Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy.
authors.forename: Marco Matteo
authors.initials: MM
authors.lastname: Ciccone
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D000068718:Rosuvastatin Calcium / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005343:Fibrinolytic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000068718:Rosuvastatin Calcium; D002784:Cholesterol
keywords: Cardiovascular disease; Cholesterol (PubChem CID: 5997); Coenzyme Q10 (PubChem CID: 5281915); Farnesylpyrophosphate (PubChem CID: 44134714); Geranylgeranylpyrophosphate (PubChem CID: 44134732); Lipid-lowering effect; Mevalonate (PubChem CID: 4478250); Nitric Oxide (PubChem CID: 145068); Pleiotrophic effect; Rosuvastatin; Rosuvastatin (PubChem CID:446157)