title: Evaluation of oxidative stress markers and intra-extracellular antioxidant activities in patients with endometriosis.
abstract: OBJECTIVE
  The aim of the study is to evaluate alterations in intracellular and extracellular antioxidant enzymes activities and serum oxidative stress markers in patients with endometriosis.
  
  
  METHODS
  The current prospective study consisted of 31 female patients with endometriosis and 27 healthy controls. Serum total thiol, native thiol, disulphide, catalase, myeloperoxidase, and ceruloplasmin concentrations were measured. Laboratory and clinical data of all participants were recorded to compare the differences between the study and the control groups.
  
  
  RESULTS
  Serum native thiol and total thiol levels in the study group were significantly lower than those in the control group [(p=0.009, p=0.03, respectively)]. Serum catalase levels are significantly higher in patients with endometriosis comparing to the control group (p=0.009).
  
  
  CONCLUSIONS
  The finding that significant differences in serum total thiol, native thiol, and catalase levels observed in endometriotic patients supports that oxidative stress carries weigh in the pathophysiological aspects of endometriosis. Also significantly low levels of extracellular antioxidants and significantly high levels of intracellular antioxidants in endometriotic patients may arise from differences of free radicals in endometriosis and the activity levels of endometriosis. These non-invasive serum markers might give us an opportunity to monitor the disease's progress during the treatment.
authors.affiliation: Department of Gynecology and Obstetrics, Ataturk Training and Research Hospital, Ankara, Turkey. Electronic address: turkyilmaz06@yahoo.com.
authors.forename: Esengul
authors.initials: E
authors.lastname: Turkyilmaz
authors.affiliation: Department of Gynecology and Obstetrics, Ataturk Training and Research Hospital, Ankara, Turkey.
authors.forename: Melahat
authors.initials: M
authors.lastname: Yildirim
authors.affiliation: Department of Gynecology and Obstetrics, Sincan Nafiz Körez State Hospital, Ankara, Turkey.
authors.forename: Busra Demir
authors.initials: BD
authors.lastname: Cendek
authors.affiliation: Department of Biochemistry, Ataturk Training and Research Hospital, Ankara, Turkey.
authors.forename: Pervin
authors.initials: P
authors.lastname: Baran
authors.affiliation: Department of Biochemistry, Ataturk Training and Research Hospital, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Alisik
authors.affiliation: Department of Gynecology and Obstetrics, Ataturk Training and Research Hospital, Ankara, Turkey.
authors.forename: Ferit
authors.initials: F
authors.lastname: Dalgaci
authors.affiliation: Department of Gynecology and Obstetrics, Yıldırım Beyazıt University, Ankara, Turkey.
authors.forename: Ayse Filiz
authors.initials: AF
authors.lastname: Yavuz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood*; D002570:Ceruloplasmin / Q000378:metabolism*; D004715:Endometriosis / Q000097:blood*; D005260:Female; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D009195:Peroxidase / Q000097:blood*; D011446:Prospective Studies; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D015415:Biomarkers; D013438:Sulfhydryl Compounds; D002374:Catalase; D009195:Peroxidase; D002570:Ceruloplasmin
keywords: Catalase; Endometriosis; Native thiol; Total thiol