title: Mitochondrial dysfunction in DDR-related cancer predisposition syndromes.
abstract: Given the key role of mitochondria in various cellular events, it is not surprising that mitochondrial dysfunction (MDF) is seen in many pathological conditions, in particular cancer. The mechanisms defining MDF are not clearly understood and may involve genetic defects, misbalance of reactive oxygen species (ROS), impaired autophagy (mitophagy), acquired mutations in mitochondrial or nuclear DNA and inability of cells to cope with the consequences. The importance of MDF arises from its detection in the syndromes with defective DNA damage response (DDR) and cancer predisposition. Here, we will focus on the dual role of these syndromes in cancer predisposition and MDF with specific emphasis on impaired autophagy.
authors.affiliation: Department of Biology, Masaryk University, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Czech Republic; Institute of Molecular Biology and Biophysics, Novosibirsk, Russia. Electronic address: lyakhovich@gmail.com.
authors.forename: Alex
authors.initials: A
authors.lastname: Lyakhovich
authors.affiliation: Novosibirsk State University, Novosibirsk, Russia.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Graifer
authors.affiliation: Department of Biology, Masaryk University, Czech Republic.
authors.forename: Barbora
authors.initials: B
authors.lastname: Stefanovie
authors.affiliation: Department of Biology, Masaryk University, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Czech Republic; National Centre for Biomolecular Research, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. Electronic address: lkrejci@chemi.muni.cz.
authors.forename: Lumir
authors.initials: L
authors.lastname: Krejci
mesh_terms: D001343:Autophagy; D004249:DNA Damage; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D009369:Neoplasms / Q000209:etiology*; D013577:Syndrome
keywords: Autophagy; Cancer predisposition syndromes; DNA damage and repair; Mitochondrial dysfunction; Mitophagy; Oxidative stress; ROS