title: Targeting Reactive Carbonyl Species with Natural Sequestering Agents.
abstract: Reactive carbonyl species generated by the oxidation of polyunsaturated fatty acids and sugars are highly reactive due to their electrophilic nature, and are able to easily react with the nucleophilic sites of proteins as well as DNA causing cellular dysfunction. Levels of reactive carbonyl species and their reaction products have been reported to be elevated in various chronic diseases, including metabolic disorders and neurodegenerative diseases. In an effort to identify sequestering agents for reactive carbonyl species, various analytical techniques such as spectrophotometry, high performance liquid chromatography, western blot, and mass spectrometry have been utilized. In particular, recent advances using a novel high resolution mass spectrometry approach allows screening of complex mixtures such as natural products for their sequestering ability of reactive carbonyl species. To overcome the limited bioavailability and bioefficacy of natural products, new techniques using nanoparticles and nanocarriers may offer a new attractive strategy for increased in vivo utilization and targeted delivery of bioactives.
authors.affiliation: Department of Nano Science &amp; Mechatronics Engineering, College of Science and Technology, Konkuk University, Chungju-si 27478, Korea. swhwang@kku.ac.kr.
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Hwang
authors.affiliation: Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Chungju-si 27478, Korea. yoonmilee@kku.ac.kr.|Interdisciplinary Research Center for Health, Konkuk University, Chungju-si 27478, Korea. yoonmilee@kku.ac.kr.
authors.forename: Yoon-Mi
authors.initials: YM
authors.lastname: Lee
authors.affiliation: Department of Pharmaceutical Sciences Pietro Pratesi, Università degli Studi di Milano, via Mangiagalli 25, Milan 20133, Italy. giancarlo.aldini@unimi.it.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Aldini
authors.affiliation: Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Chungju-si 27478, Korea. kyeum@kku.ac.kr.com.|Interdisciplinary Research Center for Health, Konkuk University, Chungju-si 27478, Korea. kyeum@kku.ac.kr.com.
authors.forename: Kyung-Jin
authors.initials: KJ
authors.lastname: Yeum
mesh_terms: D001688:Biological Products / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D013058:Mass Spectrometry; D036103:Nanotechnology; D010084:Oxidation-Reduction; D064449:Sequestering Agents / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D001688:Biological Products; D005231:Fatty Acids, Unsaturated; D006027:Glycosides; D064449:Sequestering Agents
keywords: bioefficacy; nanotechniques; natural products; reactive carbonyl species