title: [Epigenetics and Life-style diseases].
abstract: Genomic DNA in eukaryotes forms a highly-organized structure called chromatin. Epigenetic regulation of genes involves DNA methylation and modifications of the histone tails such as acetylation and methylation, which lead to a given phenotype without a change in nucleotide sequence. Both genetic and environmental factors play important roles in the development of life-style diseases. Epigenetic regulation is implicated to contribute to the interplay between the environmental and genetic factors. Advance in DNA sequencing technologies provides novel insights into transcriptional and epigenetic regulation of the genes and mechanisms by which genomic polymorphism causes diseases. We will overview recent progress in the epigenetic studies on life-style diseases.
authors.affiliation: Department of Diabetes and Metabolic Diseases, Functional Regulation of Adipocytes,Graduate School of Medicine, the University of Tokyo, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Waki
authors.affiliation: Department of Diabets and Metabolic Diseases, Graduate school of Medicine, the University of Tokyo, Japan.
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Yamauchi
authors.affiliation: Department of Diabets and Metabolic Diseases, Graduate school of Medicine, the University of Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
mesh_terms: D000818:Animals; D004247:DNA; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D008019:Life Style; D008659:Metabolic Diseases / Q000235:genetics*; D010641:Phenotype
chemical_list: D004247:DNA