title: Aerobic Copper-Promoted Radical-Type Cleavage of Coordinated Cyanide Anion: Nitrogen Transfer to Aldehydes To Form Nitriles.
abstract: We have disclosed for the first time the copper-promoted C≡N triple bond cleavage of coordinated cyanide anion under a dioxygen atmosphere, which enables a nitrogen transfer to various aldehydes. Mechanistic study of this unprecedented transformation suggests that the single electron-transfer process could be involved in the overall course. This protocol provides a new cleavage pattern for the cyanide ion and would eventually lead to a more useful synthetic pathway to nitriles from aldehydes.
authors.affiliation: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University , 29 Wangjiang Road, Chengdu 610064, P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wu
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
authors.affiliation: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University , 29 Wangjiang Road, Chengdu 610064, P. R. China.
authors.forename: Jingsong
authors.initials: J
authors.lastname: You