title: Pharmacodynamics of alacepril in healthy cats.
abstract: Objectives The aims of this study were to investigate the pharmacodynamics of alacepril and to determine the appropriate dose for clinical usage in cats. Methods Six experimental cats were used. Each cat received alacepril orally at a single dose of 1 mg/kg, 2 mg/kg and 3 mg/kg. Blood samples were collected before administration and at 2, 4, 6, 8, 12, 24, 36, 48 and 72 h after administration to measure serum angiotensin converting enzyme (ACE) activity. Systolic blood pressure was also measured at the same time point. Results Dose-dependent inhibition of ACE activity was observed. Doses of 2 mg/kg and 3 mg/kg alacepril were considered to effectively inhibit ACE activity. There were no significant differences in systolic blood pressue among groups at any time point. Conclusions and relevance Alacepril 2-3 mg/kg q24h may be an appropriate dosage for clinical use in cats.
authors.affiliation: 1 Laboratory of Surgery, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sugimoto
authors.affiliation: 1 Laboratory of Surgery, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fujii
authors.affiliation: 1 Laboratory of Surgery, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Takubo
authors.affiliation: 2 Laboratory of Physiology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
authors.forename: Toshinori
authors.initials: T
authors.lastname: Shiga
authors.affiliation: 1 Laboratory of Surgery, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sunahara
authors.affiliation: 1 Laboratory of Surgery, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Aoki
authors.affiliation: 2 Laboratory of Physiology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Orito
mesh_terms: D000284:Administration, Oral; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D002415:Cats / Q000097:blood* / Q000502:physiology; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril; D007703:Peptidyl-Dipeptidase A; C046835:alacepril