title: Biodiversity and hypervirulence of Listeria monocytogenes.
abstract: The integration of large, well-sampled collections of bacterial isolates with genomics and experimental methods provides opportunities for 'top-down' discovery of the genetic basis of phenotypes of interest. In a new report, the authors apply this approach to investigate the heterogeneity in manifestations of disease caused by Listeria monocytogenes and demonstrate that a previously uncharacterized cellobiose PTS system is involved in central nervous system infection.
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
authors.forename: Yonatan H
authors.initials: YH
authors.lastname: Grad
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Fortune
mesh_terms: D000818:Animals; D044822:Biodiversity; D023281:Genomics; D006801:Humans; D008089:Listeria monocytogenes / Q000235:genetics*; D008088:Listeriosis / Q000235:genetics*