title: Pancreatic Cancer: Current Progress and Future Challenges.
abstract: Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, remains one of the highly lethal malignancies. The highly refractory nature of clinically advanced disease and lack of a reliable biomarker for early detection are major obstructions in improving patient outcome. The recent efforts, however, in understanding the pancreatic tumor biology have resulted in the recognition of novel addictions as well as vulnerabilities of tumor cells and are being assessed for their clinical potential. This special issue highlights some of the recent progress, complexity and challenges towards improving disease outcome in patients with this lethal malignancy.
authors.affiliation: Head Pancreatic Cancer Unit, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institutes, NIH, Bethesda, MD 20892, USA.
authors.forename: S Perwez
authors.initials: SP
authors.lastname: Hussain
mesh_terms: D000818:Animals; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology
keywords: Pancreatic Cancer