title: Establishment and application of a new diagnostic definition of metabolic syndrome in the Shantou region of southern China.
abstract: The existing definitions of metabolic syndrome (MetS) may not be fully appropriate for the Shantou population because of ethnic and regional differences. We sought to establish a 95% multivariate medical reference range (MMRR) model for diagnosing MetS in Shantou adults and to evaluate the prevalence of MetS by the MMRR, JCDCG (the Chinese Guidelines), and International Diabetes Federation (IDF) criteria. A total of 4,580 participants were recruited in Shantou, southern China. We developed a MMRR model based on the combinatorial indicatrixes method for three categorized indicatrixes. According to the developed MMRR criteria, men (women) in Shantou have MetS by meeting 3 or more of the following: waist circumference ≥89 (81) cm; triglycerides level ≥1.73 (1.64) mmol/L; high-density lipoprotein cholesterol level ≤1.07 (1.05) mmol/L; blood pressure ≥138/89 (136/85) mmHg; and fasting plasma glucose ≥5.8 (5.7) mmol/L. The agreement of the MMRR with JCDCG and IDF criteria was "substantial" (both κ > 0.68), but the recommended reference values and proportion of individual components of MetS defined by the 3 criteria differed. The population-based MMRR criteria may be appropriate for diagnosing MetS in Shantou population and the model might be useful for generalization to other geographic regions.
authors.affiliation: Department of Preventive Medicine, Shantou University Medical College, Shantou, Guangdong 515041, China.
authors.forename: Zan
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Department of Sports, Shantou University Medical College, Shantou, Guangdong 515041, China.
authors.forename: Fuhua
authors.initials: F
authors.lastname: Pi
authors.affiliation: Shenzhen Baoan District Central Hospital, Shenzhen, Guangdong 518102, China.
authors.forename: Shengchao
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Preventive Medicine, Shantou University Medical College, Shantou, Guangdong 515041, China.
authors.forename: Wenya
authors.initials: W
authors.lastname: Dong
authors.affiliation: Department of Preventive Medicine, Shantou University Medical College, Shantou, Guangdong 515041, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Shenzhen Baoan District Central Hospital, Shenzhen, Guangdong 518102, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Preventive Medicine, Shantou University Medical College, Shantou, Guangdong 515041, China.
authors.forename: Qingying
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000465:Algorithms; D015415:Biomarkers; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000453:epidemiology*; D008875:Middle Aged; D008962:Models, Theoretical; D011159:Population Surveillance; D015995:Prevalence
chemical_list: D015415:Biomarkers