title: Burkholderia ginsengisoli bacteraemia: emergence of a novel pathogen.
abstract: Burkholderia ginsengisoli is a non-pathogenic Gram-negative bacterium that ordinarily serves as a plant endosymbiont. We report the first case of human infection with B. ginsengisoli presenting as bacteraemia in a young man with severe Crohn's disease. Definitive identification of the pathogen could not be accomplished with conventional techniques and required DNA sequencing. The bacteraemia may have been related to ingestion of organic vegetables and compromised gastrointestinal mucosa, coupled with treatment with tumour necrosis factor α inhibitors. Although there are no standard antibiotics to treat this pathogen, we devised a successful treatment regimen.
authors.affiliation: State University of New York at Buffalo, Buffalo, New York, USA.
authors.forename: Laura R
authors.initials: LR
authors.lastname: Marks
authors.affiliation: State University of New York at Buffalo, Buffalo, New York, USA.
authors.forename: Hema
authors.initials: H
authors.lastname: Dodd
authors.affiliation: State University of New York at Buffalo, Buffalo, New York, USA.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Russo
authors.affiliation: State University of New York at Buffalo, Buffalo, New York, USA.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Berenson
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D019117:Burkholderia / Q000235:genetics / Q000302:isolation & purification*; D019121:Burkholderia Infections / Q000175:diagnosis* / Q000188:drug therapy; D003424:Crohn Disease / Q000382:microbiology*; D004269:DNA, Bacterial / Q000235:genetics; D005516:Food Microbiology; D006801:Humans; D008297:Male; D017422:Sequence Analysis, DNA; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial