title: Comparison of serum zinc, calcium, and magnesium concentrations in women with pregnancy-induced hypertension and healthy pregnant women: A meta-analysis.
abstract: OBJECTIVE
  The relationship between serum zinc, magnesium, and calcium levels and pregnancy-induced hypertension (PIH) is controversial. The aim of our study was to determine whether or not serum zinc, magnesium, and calcium levels are associated with PIH.
  
  
  METHODS
  In our study, we searched databases, including Wangfang, Chinese National Knowledge Infrastructure, and PubMed, to find literature regarding the relationship between PIH and serum trace elements. Meta-analysis was performed using the Review Manager5.3 software.
  
  
  RESULTS
  A total of 14 articles were included in our study. The results of the meta-analysis indicated that patients with PIH had lower serum zinc (SMD = -1.14; 95% CI] = -1.69, -0.59; P < 0.05), calcium (MD = -0.26; 95% CI = -0.36, -0.15; P < 0.05), and magnesium concentration (MD = -0.0.06; 95% CI = -0.08, -0.05; P < 0.05) than healthy gravidas.
  
  
  CONCLUSIONS
  Our research suggests that serum zinc, calcium, and magnesium concentrations may have an effect on PIH. Thus, the serum zinc, calcium, and magnesium levels could be measured for PIH patients.
authors.affiliation: a School of Public Health , Wannan Medical College , Wuhu , Anhui , China.
authors.forename: Lianping
authors.initials: L
authors.lastname: He
authors.affiliation: b School of Clinic Medicine , Wannan Medical College , Wuhu , Anhui , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lang
authors.affiliation: a School of Public Health , Wannan Medical College , Wuhu , Anhui , China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Li
authors.affiliation: b School of Clinic Medicine , Wannan Medical College , Wuhu , Anhui , China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: a School of Public Health , Wannan Medical College , Wuhu , Anhui , China.
authors.forename: Yingshui
authors.initials: Y
authors.lastname: Yao
mesh_terms: D002118:Calcium / Q000097:blood*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D008274:Magnesium / Q000097:blood*; D011247:Pregnancy; D015032:Zinc / Q000097:blood*
chemical_list: D008274:Magnesium; D015032:Zinc; D002118:Calcium
keywords: Calcium; case-control study; hypertension; magnesium; zinc