title: Comparison of efficacy and toxicity of doxorubicin and mitoxantrone in combination chemotherapy for canine lymphoma.
abstract: Forty-four dogs with multicentric lymphoma were treated using a cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) induction protocol or treated using a cyclophosphamide, mitoxantrone, vincristine, and prednisolone (CMOP) induction protocol. There was no statistical difference in signalment and the presence of historical negative prognostic factors between the groups. The median progression-free survival (PFS) in the CHOP and CMOP groups were 222 d and 162 d, respectively (P = 0.75). The median survival time (MST) of dogs in CHOP and CMOP groups were 318 d and 242 d, respectively (P = 0.63). Anorexia and diarrhea episodes were significantly higher in the CHOP group than in the CMOP group (P = 0.02 and P = 0.01, respectively). These results suggest that the CMOP protocol provides similar PFS, MST and causes fewer side effects compared to the CHOP protocol. Therefore, the CMOP protocol may be another treatment choice for canine multicentric lymphoma.
authors.affiliation: National Taiwan University Veterinary Hospital, College of Bioresources and Agriculture (Wang), Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine (Wang, Liao), Graduate Institute of Veterinary Clinical Science, School of Veterinary Medicine (Lee), Animal Cancer Center, College of Bioresources and Agriculture (Lee, Liao), National Taiwan University, Taipei, 10672, Taiwan, Republic of China.
authors.forename: Shang-Lin
authors.initials: SL
authors.lastname: Wang
authors.affiliation: National Taiwan University Veterinary Hospital, College of Bioresources and Agriculture (Wang), Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine (Wang, Liao), Graduate Institute of Veterinary Clinical Science, School of Veterinary Medicine (Lee), Animal Cancer Center, College of Bioresources and Agriculture (Lee, Liao), National Taiwan University, Taipei, 10672, Taiwan, Republic of China.
authors.forename: Jih-Jong
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: National Taiwan University Veterinary Hospital, College of Bioresources and Agriculture (Wang), Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine (Wang, Liao), Graduate Institute of Veterinary Clinical Science, School of Veterinary Medicine (Lee), Animal Cancer Center, College of Bioresources and Agriculture (Lee, Liao), National Taiwan University, Taipei, 10672, Taiwan, Republic of China.
authors.forename: Albert Taiching
authors.initials: AT
authors.lastname: Liao
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004317:Doxorubicin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D008223:Lymphoma / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D008942:Mitoxantrone / Q000009:adverse effects / Q000627:therapeutic use*; D011241:Prednisone / Q000627:therapeutic use; D011446:Prospective Studies; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D008942:Mitoxantrone; D011241:Prednisone