title: A new polymorphic form of metoprolol succinate.
abstract: Only one crystal form of metoprolol succinate (Form I) was reported during previous researches and production. In this study, a new polymorph of metoprolol succinate (here named as Form II) was discovered and investigated by X-ray diffraction, thermoanalysis and infrared spectroscopy. The results show its crystal structure and thermal properties are significantly different with Form I. Compared with Form I, Form II exhibits specific diffraction pattern, lower melting temperature and weaker hydrogen bond effect. The thermostability testing suggests Form II is a metastable crystal form and will gradually transform into Form I undergoing treatment of high temperature and humidity. Metastable crystal form generally has better dissolubility than its corresponding stable form. Subsequent measurement also verified that Form II can dissolve in the water more quickly than Form I.
authors.affiliation: a Engineering Research Center for Eco-Dyeing and Finishing of Textiles, Ministry of Education, Zhejiang Sci-Tech University , Hangzhou , China and.
authors.forename: Mengqing
authors.initials: M
authors.lastname: Zhou
authors.affiliation: a Engineering Research Center for Eco-Dyeing and Finishing of Textiles, Ministry of Education, Zhejiang Sci-Tech University , Hangzhou , China and.
authors.forename: Ju
authors.initials: J
authors.lastname: Ao
authors.affiliation: a Engineering Research Center for Eco-Dyeing and Finishing of Textiles, Ministry of Education, Zhejiang Sci-Tech University , Hangzhou , China and.
authors.forename: Song
authors.initials: S
authors.lastname: Liu
authors.affiliation: b Zhejiang Apeloa Medical Technology Co, Ltd , Jinhua , China.
authors.forename: Chaogang
authors.initials: C
authors.lastname: Wu
authors.affiliation: b Zhejiang Apeloa Medical Technology Co, Ltd , Jinhua , China.
authors.forename: Anping
authors.initials: A
authors.lastname: Lai
authors.affiliation: b Zhejiang Apeloa Medical Technology Co, Ltd , Jinhua , China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Gao
authors.affiliation: a Engineering Research Center for Eco-Dyeing and Finishing of Textiles, Ministry of Education, Zhejiang Sci-Tech University , Hangzhou , China and.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000959:Antihypertensive Agents / Q000737:chemistry*; D003460:Crystallization; D004355:Drug Stability; D006860:Hydrogen Bonding; D008790:Metoprolol / Q000737:chemistry*; D033362:Powder Diffraction; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D000959:Antihypertensive Agents; D008790:Metoprolol
keywords: Hydrogen bond; metoptolol succinate; polymorphic form; thermostability