title: A new isocoumarin from the aerial parts of Aconitum gymnandrum.
abstract: A new isocoumarin, along with 10 known compounds, was isolated from the aerial parts of Aconitum gymnandrum. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Among the known compounds, compound 11 was obtained as a natural product for the first time, which was previously reported as a synthetic product. In addition, compounds 1-5, 7 and 9 were tested for their cytotoxicity against four human cancer cell lines. The results showed that compounds 3, 4 and 7 displayed cytotoxicity against lung cancer A549 and gastric cancer MGC80, respectively, whereas 5 and 9 showed selective cytotoxicity against hepatocellular carcinoma HepG2.
authors.affiliation: a Key Laboratory of Tibetan Medicine Research of CAS and Key Laboratory for Tibetan Medicine of Qinghai Province , Northwest Institute of Plateau Biology, Chinese Academy of Sciences , Xinning , P.R. China.|c University of Chinese Academy of Sciences , Beijing , P.R. China.
authors.forename: Jian-Qiang
authors.initials: JQ
authors.lastname: Zhao
authors.affiliation: b Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province , Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou , P.R. China.|c University of Chinese Academy of Sciences , Beijing , P.R. China.
authors.forename: Yan-Ming
authors.initials: YM
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Tibetan Medicine Research of CAS and Key Laboratory for Tibetan Medicine of Qinghai Province , Northwest Institute of Plateau Biology, Chinese Academy of Sciences , Xinning , P.R. China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Tibetan Medicine Research of CAS and Key Laboratory for Tibetan Medicine of Qinghai Province , Northwest Institute of Plateau Biology, Chinese Academy of Sciences , Xinning , P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Dang
authors.affiliation: b Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province , Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou , P.R. China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Shi
authors.affiliation: a Key Laboratory of Tibetan Medicine Research of CAS and Key Laboratory for Tibetan Medicine of Qinghai Province , Northwest Institute of Plateau Biology, Chinese Academy of Sciences , Xinning , P.R. China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Mei
authors.affiliation: a Key Laboratory of Tibetan Medicine Research of CAS and Key Laboratory for Tibetan Medicine of Qinghai Province , Northwest Institute of Plateau Biology, Chinese Academy of Sciences , Xinning , P.R. China.
authors.forename: Yan-Duo
authors.initials: YD
authors.lastname: Tao
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification*; D035261:Plant Components, Aerial / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D049934:Isocoumarins
keywords: Aconitum gymnandrum; cytotoxic activity; isocourmain