title: Access to 1,4-Dihydrobenzo[e][1,2,4]triazin-4-yl Derivatives.
abstract: A simple, one-pot method for the preparation of 1-aryl-3-phenyl-1,4-dihydrobenzo[e][1,2,4]triazin-4-yl radicals by addition of aryllithium to the readily available 3-phenylbenzo[e][1,2,4]triazine followed by aerial oxidation is described. The intermediate anion is also trapped as an N-benzyloxycarbonyl derivative and purified prior to deprotection and oxidation to the radical. The method was demonstrated for nine (het)arenes, and the regioselectivity of nucleophilic addition to the benzo[e][1,2,4]triazine and trapping of the intermediate anion with electrophiles was assessed computationally.
authors.affiliation: Department of Chemistry, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Christos P
authors.initials: CP
authors.lastname: Constantinides
authors.affiliation: Faculty of Chemistry, University of Łódź , 91403 Łódź, Poland.
authors.forename: Emilia
authors.initials: E
authors.lastname: Obijalska
authors.affiliation: Faculty of Chemistry, University of Łódź , 91403 Łódź, Poland.|Center of Molecular and Macromolecular Studies, Polish Academy of Sciences , 90363 Łódź, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Kaszyński