title: [Expression and Clinical Significance of MAGE-C2 in Lung Adenocarcinoma].
abstract: BACKGROUND
  The aim of this study is to detect the expression of melanoma antigen-C2 (MAGE-C2) in lung adenocarcinoma tissues and adjacent non-cancerousous tissues and analyze its clinical significance.
  
  
  METHODS
  The expression level of MAGE-C2 mRNA and MAGE-C2 protein were measured in 87 cases of lung adenocarcinoma tissues and adjacent non-cancerous tissues were detected by Real-time fluorescence quantitative PCR and Western blot.
  
  
  RESULTS
  Over-expression of the MAGE-C2 mRNA and MAGE-C2 protein were observed in lung adenocarcinoma tissues (53/87, 60.9%), but nor in adjacent non-cancerous tissues. The expressions of MAGE-C2 mRNA and MAGE-C2 protein were closely associated with clinical stage, metastasis and differentiation (P<0.05). The expression rate of MAGE-C2 mRNA had no relationship with gender, age, smoking (P>0.05). The expression of MAGE-C2 had an adverse effect on overall survival rate (P<0.05).
  
  
  CONCLUSIONS
  Over-expression of the MAGE-C2 mRNA and protein is existed in lung adenocarcinoma. The high expression of MAGE-C2 may be closely related to the occurrence and development in lung adenocarcinoma. MAGE-C2 may predict a poor prognosis and could be as a novel lung adenocarcinoma molecule marker. .
authors.affiliation: Cancer Center, the Affiliated Hospital of Qingdao Universitiy, Qingdao 266003, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Guo
authors.affiliation: Cancer Center, the Affiliated Hospital of Qingdao Universitiy, Qingdao 266003, China.
authors.forename: Mengshi
authors.initials: M
authors.lastname: Lu
authors.affiliation: Cancer Center, the Affiliated Hospital of Qingdao Universitiy, Qingdao 266003, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.affiliation: Cancer Center, the Affiliated Hospital of Qingdao Universitiy, Qingdao 266003, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D009367:Neoplasm Staging; D055815:Young Adult
chemical_list: D000951:Antigens, Neoplasm; C405429:MAGEC2 protein, human; D009363:Neoplasm Proteins