title: The Potential Prognostic Value of MicroRNA-429 for Human Gliomas.
abstract: MicroRNA-429 (miR-429) is reported to be frequently dysregulated in cancer. Studies have demonstrated that miR-429 functions as either an oncogene or a tumor suppressor depending on the tumor type. To date, its role in human glioma has not yet been reported. The aim of this study was to investigate the expression levels, clinicopathological significance, and prognostic significance of miR-429 in glioma tissues. Quantitative real-time PCR assay was performed to detect miR-429 expression in human glioma and non-neoplastic brain tissues. The association of miR-429 expression with clinicopathological features and prognoses of glioma patients were analyzed by SPSS 17.0 statistical software. The expression levels of miR-429 were found to be distinctly increased in glioma tissues compared to non-neoplastic brain tissues (P<0.01) with ascending pathological grade. The 5-year survival rate of patients with high miR-429 expression was significantly lower than those with low miR-429 expression (P<0.001). Moreover, multivariate Cox regression analyses showed that miR-429 high expression is an independent prognostic factor for glioma patients. Taken together, miR-429, was significantly up-regulated in glioma tissues. Therefore, miR-429 could be considered as an independent prognostic factor and potential therapeutic target for glioma.
authors.affiliation: Department of Clinical Laboratory, The People's Hospital of Dongying, Dongying, Shandong, China.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Clinical Laboratory, The People's Hospital of Dongying, Dongying, Shandong, China.
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratory, The Second Hospital, Shandong University, Jinan, Shandong, China cyjsdey@126.com.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D060888:Real-Time Polymerase Chain Reaction; D015854:Up-Regulation / Q000235:genetics; D055815:Young Adult
chemical_list: C546363:MIRN429 microRNA, human; D035683:MicroRNAs
keywords: gliomas; microRNA-429; prognosis