title: Proteomics and the search for welfare and stress biomarkers in animal production in the one-health context.
abstract: Stress and welfare are important factors in animal production in the context of growing production optimization and scrutiny by the general public. In a context in which animal and human health are intertwined aspects of the one-health concept it is of utmost importance to define the markers of stress and welfare. These are important tools for producers, retailers, regulatory agents and ultimately consumers to effectively monitor and assess the welfare state of production animals. Proteomics is the science that studies the proteins existing in a given tissue or fluid. In this review we address this topic by showing clear examples where proteomics has been used to study stress-induced changes at various levels. We adopt a multi-species (cattle, swine, small ruminants, poultry, fish and shellfish) approach under the effect of various stress inducers (handling, transport, management, nutritional, thermal and exposure to pollutants) clearly demonstrating how proteomics and systems biology are key elements to the study of stress and welfare in farm animals and powerful tools for animal welfare, health and productivity.
authors.affiliation: Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain. anna.bassols@uab.cat.
authors.forename: A
authors.initials: A
authors.lastname: Marco-Ramell
authors.affiliation: Instituto de Biologia Experimental e Tecnologica, Oeiras, Portugal and CIISA/FMV - Centro Interdisciplinar de Investigação em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal.
authors.forename: A M
authors.initials: AM
authors.lastname: de Almeida
authors.affiliation: Department of Clinical and Experimental Medicine, Cell Biology, Faculty of Medicine, Linköping University, Linköping, Sweden and IKERBASQUE, Basque Foundation for Science, Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Cristobal
authors.affiliation: CCMAR, Center of Marine Science, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Rodrigues
authors.affiliation: Istituto Sperimentale Italiano L. Spallanzani, Milano, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Roncada
authors.affiliation: Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain. anna.bassols@uab.cat.
authors.forename: A
authors.initials: A
authors.lastname: Bassols
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000827:Animal Welfare; D000818:Animals; D015415:Biomarkers; D002417:Cattle; D000072480:Farms; D005399:Fishes; D063427:Food Quality; D006801:Humans; D008461:Meat Products / Q000592:standards; D011200:Poultry; D020543:Proteome; D040901:Proteomics / Q000379:methods; D012463:Saliva / Q000378:metabolism; D012621:Seasons; D013312:Stress, Physiological; D013552:Swine; D049490:Systems Biology; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D020543:Proteome