title: Biocompatible hydrogelators based on bile acid ethyl amides.
abstract: Four novel bile acid ethyl amides were synthetized using a well-known method. All the four compounds were characterized by IR, SEM, and X-ray crystal analyses. In addition, the cytotoxicity of the compounds was tested. Two of the prepared compounds formed organogels. Lithocholic acid derivative 1 formed hydrogels as 1% and 2% (w/v) in four different aqueous solutions. This is very intriguing regarding possible uses in biomedicine.
authors.affiliation: University of Jyvaskyla, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyvaskyla, Finland.
authors.forename: Riikka
authors.initials: R
authors.lastname: Kuosmanen
authors.affiliation: University of Jyvaskyla, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyvaskyla, Finland.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Puttreddy
authors.affiliation: University of Jyvaskyla, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyvaskyla, Finland.
authors.forename: Roosa-Maria
authors.initials: RM
authors.lastname: Willman
authors.affiliation: University of Jyvaskyla, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyvaskyla, Finland.
authors.forename: Ilkka
authors.initials: I
authors.lastname: Äijäläinen
authors.affiliation: Palacký University in Olomouc, Department of Medical Chemistry and Biochemistry, Hněvotínská 3, CZ-775 15 Olomouc, Czech Republic.
authors.forename: Adéla
authors.initials: A
authors.lastname: Galandáková
authors.affiliation: Palacký University in Olomouc, Department of Medical Chemistry and Biochemistry, Hněvotínská 3, CZ-775 15 Olomouc, Czech Republic.
authors.forename: Jitka
authors.initials: J
authors.lastname: Ulrichová
authors.affiliation: University of Jyvaskyla, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyvaskyla, Finland.
authors.forename: Hannu
authors.initials: H
authors.lastname: Salo
authors.affiliation: University of Jyvaskyla, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyvaskyla, Finland.
authors.forename: Kari
authors.initials: K
authors.lastname: Rissanen
authors.affiliation: University of Jyvaskyla, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyvaskyla, Finland. Electronic address: elina.i.sievanen@jyu.fi.
authors.forename: Elina
authors.initials: E
authors.lastname: Sievänen
mesh_terms: D016475:3T3 Cells; D000577:Amides / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D020100:Hydrogels / Q000737:chemistry*; D008095:Lithocholic Acid / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D014867:Water / Q000737:chemistry
chemical_list: D000577:Amides; D001672:Biocompatible Materials; D020100:Hydrogels; D014867:Water; D008095:Lithocholic Acid
keywords: Amide; Bile acid; Biocompatibility; Self-assembly; Supramolecular hydrogel