title: Silane modified upconversion nanoparticles with multifunctions: imaging, therapy and hypoxia detection.
abstract: Herein, we report a facile route to synthesize silane coated upconversion nanoparticles (UCNPs@silane) with an ultrathin layer (the thickness: 1-2 nm), which not only provides good biocompatibility, but also affords hydrophobic interspace to load organic molecules to realize multifunctions. Besides the function of upconversion imaging of UCNPs, cancer therapy and oxygen level detection can also be realized by the addition of chemotherapy drug, PTX, and oxygen sensitive molecules, Platinum (II) octaethylporphine (PtOEP). In bio-experiments, besides the MTT assays, therapy efficacy of UCNPs@PTX@silane can also be detected with the confocal laser scanning microscopy (CLSM) by staining methods. UCNPs@PtOEP@silane can afford minimally invasive analysis of dissolved oxygen and then respond sensitively to the variance of intracellular oxygen concentration affected by therapeutic UCNPs@PTX@silane.
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
authors.forename: Shihan
authors.initials: S
authors.lastname: Xu
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
authors.forename: Xinran
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Xu
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
authors.forename: Biao
authors.initials: B
authors.lastname: Dong
authors.affiliation: Department of Physics, Changchun Normal University, Changchun 130032, P. R. China.
authors.forename: Xuesong
authors.initials: X
authors.lastname: Qu
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
authors.forename: Boting
authors.initials: B
authors.lastname: Chen
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: College of Physics, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
authors.forename: Tianxiang
authors.initials: T
authors.lastname: Zhang
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
authors.forename: Sai
authors.initials: S
authors.lastname: Xu
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Song
mesh_terms: D001672:Biocompatible Materials; D015374:Biosensing Techniques; D002460:Cell Line; D002470:Cell Survival; D006801:Humans; D000860:Hypoxia; D042541:Intracellular Space / Q000378:metabolism; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use / Q000648:ultrastructure; D061848:Optical Imaging; D010101:Oxygen Consumption; D012821:Silanes / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D012821:Silanes