title: A New Lycopodine-type Alkaloid from Lycopodium japonicum.
abstract: A new lycopodine-type alkaloid, 12β-hydroxy-acetylfawcettiine N-oxide (1), together with seven known analogues, acetyllycoposerramine M (2), lycopodine (3), lycoclavine (4), diphaladine A (5), lycoposerramine K (6), 11β-hydroxy-12-epilycodoline (7) and fawcettiine (8), were isolated from Lycopodium japonicum. Their structures were established by mass spectrometry and 1D and 2D NMR techniques. The isolated alkaloids were assayed for their inhibition activities against acetylcholinesterase, but no inhibitory activities for the compounds were detected.
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhan
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Yegao
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032502:Lycopodium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011807:Quinolizines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D011807:Quinolizines; C016542:lycopodine
keywords: Lycopodium japonicum; lycopodiaceae; lycopodine-type alkaloids