title: The effect of moderate-intensity exercise on the expression of HO-1 mRNA and activity of HO in cardiac and vascular smooth muscle of spontaneously hypertensive rats.
abstract: The objective of this study was to observe the effects of moderate-intensity training on the activity of heme oxygenase (HO) and expression of HO-1 mRNA in the aorta and the cardiac muscle of spontaneously hypertensive rats (SHRs). After 9 weeks of swimming exercise, the activity of HO and expression of HO-1 mRNA in the SHRs were measured. The resting blood pressure in the exercise group was increased by 1.7% (P > 0.05), whereas it was significantly elevated by 10.3% (P < 0.01) in the SHR rats. Compared with animals in the control and sedentary groups, the expression level of HO-1 mRNA of aorta and cardiac muscle in the exercise group was significantly enhanced (P < 0.01). The HO activity and the content of plasma carbon monoxide (CO) in the sedentary group were dramatically decreased (P < 0.05 and P < 0.01, respectively) compared with the control group. HO activity and content of plasma CO in the exercise group were significantly higher compared with those in the sedentary group (P < 0.05 and P < 0.01, respectively). The HO/CO metabolic pathway might be involved in the regulation of blood pressure of the SHR models.
authors.affiliation: a Rehabilitation College of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China.
authors.forename: Cailing
authors.initials: C
authors.lastname: Ren
authors.affiliation: b Shanghai Normal University Physical Education College, No. 100 in Guilin Road, Xuhui District, Shanghai 200234, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Qi
authors.affiliation: c Public Health Department of Weifang Medical College, Weifang 261000, Shandong Province, China.
authors.forename: Wanwei
authors.initials: W
authors.lastname: Li
authors.affiliation: b Shanghai Normal University Physical Education College, No. 100 in Guilin Road, Xuhui District, Shanghai 200234, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002248:Carbon Monoxide / Q000097:blood; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism; D008297:Male; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar
chemical_list: D012333:RNA, Messenger; D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1
keywords: HO activity; HO-1 mRNA expression; activité de l’HO; cardiac and vascular smooth muscle; entraînement physique; exercise; expression de l’ARNm du gène HO-1; muscles cardiaque et vasculaire lisse; rats spontanément hypertendus; spontaneously hypertensive rats