title: Genistein attenuates oxidative damage in preeclamptic placental trophoblast.
abstract: OBJECTIVE
  To evaluate the effect of genistein supplementation on the oxidative/nitrative stress and antioxidant capacity of normotensive and preeclamptic placental trophoblast.
  
  
  METHODS
  The stress status of placental trophoblast was assessed by measuring their respective markers before and after incubation with genistein.
  
  
  RESULTS
  A significant increase in stress along with decrease in antioxidant status was observed in preeclamptic placental trophoblast, whereas genistein incubation significantly alters oxidant-antioxidant status.
  
  
  CONCLUSIONS
  The study revealed that genistein may play a significant role in controlling oxidative/nitrative stress during preeclampsia. Hence, genistein can be used as an effective dietary supplement for the treatment and management of preeclampsia.
authors.affiliation: a Department of Biochemistry , Bharathi Women's College, Affiliated to University of Madras , Chennai , Tamil Nadu , India.
authors.forename: Padmini
authors.initials: P
authors.lastname: Ekambaram
authors.affiliation: a Department of Biochemistry , Bharathi Women's College, Affiliated to University of Madras , Chennai , Tamil Nadu , India.
authors.forename: Chithra
authors.initials: C
authors.lastname: Balan
authors.affiliation: a Department of Biochemistry , Bharathi Women's College, Affiliated to University of Madras , Chennai , Tamil Nadu , India.
authors.forename: Christina Joseph Mary
authors.initials: CJ
authors.lastname: Susai
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D005260:Female; D019833:Genistein / Q000494:pharmacology*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D014327:Trophoblasts / Q000187:drug effects* / Q000378:metabolism; D055815:Young Adult
chemical_list: D000975:Antioxidants; D019833:Genistein
keywords: Antioxidant; estrogen; genistein; preeclampsia; stress; trophoblast