title: Cytotoxicity studies of water soluble coordination compounds with a [Mo2O2S2](2+) core.
abstract: Selected molybdenum sulfur compounds with the formulas (M)[Mo2O2S4L] where (Et4N)2(1), L=S4(2-), (Et4N)(2), L=Cp, (3), L=DMF, K(5), L=serine, M=Et4N(+), K(+), Na(+) and [Mo2O2S2L2] where Na2(4), L=cysteine, and (6), L=threonine, were prepared and subjected to cytotoxicity studies in vitro. The results were analyzed to rank the compounds according to their relative cytotoxicity and to correlate the observed toxicity to specific composition. The results guide future efforts to synthesize highly water soluble, non-toxic, compounds. Strong correlation was observed between toxicity and cation selection, as well as selection of biocompatible ligands combined with alkali metal salts. The most toxic compound analyzed showed about 50 times less cytotoxicity than the cisplatin reference compound in HT-29 cells. Preliminary results from in vivo data agree with the ranking obtained in vitro.
authors.affiliation: Science Institute, University of Iceland, Dunhagi 3, 107 Reykjavik, Iceland.
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Gretarsdóttir
authors.affiliation: Ruhr Universität Bochum, Universitaetsstrasse 150, D-44780 Bochum, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Bobersky
authors.affiliation: Ruhr Universität Bochum, Universitaetsstrasse 150, D-44780 Bochum, Germany.
authors.forename: Nils
authors.initials: N
authors.lastname: Metzler-Nolte
authors.affiliation: Science Institute, University of Iceland, Dunhagi 3, 107 Reykjavik, Iceland. Electronic address: sgsuman@hi.is.
authors.forename: Sigridur G
authors.initials: SG
authors.lastname: Suman
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000494:pharmacology*; D003545:Cysteine / Q000737:chemistry; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D061986:MCF-7 Cells; D008672:Metals, Alkali / Q000737:chemistry; D008982:Molybdenum / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D012694:Serine / Q000737:chemistry; D012995:Solubility; D013329:Structure-Activity Relationship; D013455:Sulfur / Q000737:chemistry*; D013912:Threonine / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D008672:Metals, Alkali; D009942:Organometallic Compounds; D014867:Water; D013912:Threonine; D012694:Serine; D013455:Sulfur; D008982:Molybdenum; D003545:Cysteine; D002945:Cisplatin
keywords: Cytotoxicity; Molybdenum; Sulfur