title: Chemical Constituents and Their Bioactivities of Mushroom Phellinus rhabarbarinus.
abstract: Phellinus rhabarbarinus soaked in wine has folk usages by local residents of Ailao mountain of Yunnan province, China, which were to daub the wound to prevent infection and to drink to enhance immunity and treat other diseases such as cough, gastritis, and cancer. Systemic investigation on the chemical constituents of fruiting bodies of P. rhabarbarinus resulted in the isolation of 11 lanostane triterpenoids (1-10) including three new ones, namely, phellibarins A-C (1-3), together with five ergosterols (11-15). This is the first time reporting secondary metabolites of P. rhabarbarinus. Compounds 2, 3, 7, and 8 showed inhibitory activities against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages, whereas compounds 2-4, 6, 7, and 10 exhibited cytotoxicities against human cancer cell lines. The results of this assessment suggested that the lanostane triterpenoids in fruiting bodies of P. rhabarbarinus played key roles in its folk usages.
authors.affiliation: College of Pharmacy, South-Central University for Nationalities , Wuhan 430074, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.affiliation: School of Agriculture and Biological Technic, Yunnan Agricultural University , Kunming 650201, China.
authors.forename: Jin-Long
authors.initials: JL
authors.lastname: Cai
authors.affiliation: College of Pharmacy, South-Central University for Nationalities , Wuhan 430074, China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650, China.
authors.forename: Zhong-Yu
authors.initials: ZY
authors.lastname: Zhou
authors.affiliation: College of Pharmacy, South-Central University for Nationalities , Wuhan 430074, China.
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.affiliation: College of Pharmacy, South-Central University for Nationalities , Wuhan 430074, China.
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D002681:China; D004875:Ergosterol / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D000067996:RAW 264.7 Cells; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes; D009569:Nitric Oxide; D004875:Ergosterol
keywords: NO production inhibition; Phellinus rhabarbarinus; cytotoxicity; lanostane triterpenoid