title: Effect of goserelin and leuprolide added to the semen on reproductive performance in rabbits - Short communication.
abstract: The aim of this study was to evaluate the ability of two synthetic GnRH analogues, goserelin and leuprolide, to induce ovulation in rabbit does using intravaginal administration. A total of 252 primiparous lactating does were randomly divided into five groups that, at the time of insemination, received the following treatments for ovulation induction: 1 µg of buserelin administered intramuscularly (control group), 5 µg of goserelin added to the semen dose (Group G5), 10 µg of goserelin added to the semen dose (Group G10), 5 µg of leuprolide added to the semen dose (Group L5), and 10 µg of leuprolide added to the semen dose (Group L10). The kindling rate was 80.5% in Group G10 and 75.0% in Group L10; these values are comparable to the kindling rate obtained in the control group (85.9%). The kindling rates in Groups G5 and L5 were significantly lower than in the control group (60.0%, 54.2% and 85.9%, respectively). The number of live-born rabbits was not significantly affected by the ovulation induction treatment. As regards the total number of rabbits born the only significant difference was observed between Groups G5 and L5. This study shows the possibility of inducing ovulation in rabbits by adding goserelin and leuprolide directly to the semen dose.
authors.affiliation: Department of Biotechnology of Animal Reproduction, National Research Institute of Animal Production , Krakowska 1, 32-083 Balice/Kraków , Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Gogol
mesh_terms: D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone; D017273:Goserelin / Q000494:pharmacology*; D007315:Insemination, Artificial; D007774:Lactation; D016729:Leuprolide / Q000494:pharmacology*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011817:Rabbits; D012661:Semen / Q000187:drug effects* / Q000502:physiology
chemical_list: D017273:Goserelin; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide
keywords: GnRH analogue; Rabbit; insemination; ovulation induction