title: Prospective, Randomized, Double-Blind, Parallel-Group, Comparative Effectiveness Clinical Trial Comparing a Powder Vehicle Compound of Vitamin D With an Oil Vehicle Compound in Adults With Cystic Fibrosis.
abstract: There is little consensus on the most efficacious vehicle substance for vitamin D supplements. Fat malabsorption may impede the ability of patients with cystic fibrosis (CF) to absorb vitamin D in an oil vehicle. We hypothesized that vitamin D contained in a powder vehicle would be absorbed more efficiently than vitamin D contained in an oil vehicle in patients with CF.
  
  
  
  In this double-blind, randomized controlled trial, hospitalized adults with CF were given a one-time bolus dose of 100,000 IU of cholecalciferol (D3) in a powder-based or oil-based vehicle. Serum D3, 25-hydroxyvitamin D, and parathyroid hormone concentrations were analyzed at 0, 12, 24, and 48 hours posttreatment. The area under the curve for serum D3and the 12-hour time point were also assessed as indicators of D3absorption.
  
  
  
  This trial was completed by 15 patients with CF. The median (interquartile range) age, body mass index, and forced expiratory volume in 1 second were 23.7 (19.9-33.2) years, 19.9 (18.6-22.6) kg/m2, and 63% (37%-80%), respectively. The increase in serum D3and the area under the curve was greater in the powder group ( P = .002 and P = .036, respectively). Serum D3was higher at 12 hours in the powder group compared with the oil group ( P = .002), although levels were similar between groups by 48 hours.
  
  
  
  In adults with CF, cholecalciferol is more efficiently absorbed in a powder compared with an oil vehicle. Physicians should consider prescribing vitamin D in a powder vehicle in patients with CF to improve the absorption of vitamin D from supplements.
authors.affiliation: 1 Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Hermes
authors.affiliation: 1 Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Alvarez
authors.affiliation: 1 Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Moon J
authors.initials: MJ
authors.lastname: Lee
authors.affiliation: 1 Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Supavit
authors.initials: S
authors.lastname: Chesdachai
authors.affiliation: 1 Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Daud
authors.initials: D
authors.lastname: Lodin
authors.affiliation: 3 Heartland Assays, LLC, Ames, Iowa, USA.
authors.forename: Ron
authors.initials: R
authors.lastname: Horst
authors.affiliation: 1 Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.|2 Atlanta VA Medical Center, Decatur, Georgia, USA.
authors.forename: Vin
authors.initials: V
authors.lastname: Tangpricha
mesh_terms: D000328:Adult; D002762:Cholecalciferol / Q000097:blood; D003550:Cystic Fibrosis / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010865:Pilot Projects; D011208:Powders; D011446:Prospective Studies; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood*; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000209:etiology; D055815:Young Adult
chemical_list: D010281:Parathyroid Hormone; D011208:Powders; D014807:Vitamin D; D002762:Cholecalciferol
keywords: cholecalciferol; cystic fibrosis; ergocalciferol; malabsorption; pancreatic insufficiency; vehicle; vitamin D; vitamin D3