title: Galactosaminogalactan of Aspergillus fumigatus, a bioactive fungal polymer.
abstract: Galactosaminogalactan (GAG) is an extracellular polysaccharide produced by the mycelium of the opportunistic human fungal pathogen Aspergillus fumigatus GAG is the first polysaccharide described as a virulence factor in medical mycology. This review presents our current knowledge of the structural organization and biosynthesis of this polymer. The function of this molecule as an adhesin that also masks Aspergillus PAMPs and the impact of GAG on the modulation of the host immune response by inducing neutropenia and blocking the IL-1 signaling pathway also will be emphasised.
authors.affiliation: Unité des Aspergillus, Institut Pasteur, Paris.
authors.forename: Benoit
authors.initials: B
authors.lastname: Briard
authors.affiliation: Unité des Aspergillus, Institut Pasteur, Paris.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Muszkieta
authors.affiliation: Unité des Aspergillus, Institut Pasteur, Paris.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Latgé
authors.affiliation: Unité des Aspergillus, Institut Pasteur, Paris thierry.fontaine@pasteur.fr.
authors.forename: Thierry
authors.initials: T
authors.lastname: Fontaine
mesh_terms: D000818:Animals; D001228:Aspergillosis / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000235:genetics / Q000378:metabolism*; D001704:Biopolymers / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D011134:Polysaccharides / Q000378:metabolism*
chemical_list: D001704:Biopolymers; D005656:Fungal Proteins; D011134:Polysaccharides; C062157:galactosaminogalactan
keywords: Aspergillus fumigatus; IL-1Ra; galactosaminogalactan; neutrophil apoptosis; virulence factor