title: A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer.
abstract: The insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of interleukin-1A (IL1A) has been studied intensively and has been shown to affect tumor risk. We studied the frequency of the IL1A gene polymorphism rs3783553 and evaluated its relationship with breast cancer (BC). A hospital-based case-control study comprising 228 patients with histologically confirmed BC and 241 healthy subjects was conducted. Polymerase chain reaction was used to detect the IL1A rs3783553 polymorphism. The ins/ins (ttca/ttca) genotype was significantly associated with a decreased risk of BC compared with the del/del (-/-) genotype (OR = 0.48, 95% CI = 0.27-0.85). Moreover, the ins (ttca) allele distribution between cases and controls was significantly different from the del (-) allele distribution (OR = 0.74, 95% CI = 0.57-0.96). Thus, the rs3783553 polymorphism is associated with a decreased incidence of breast cancer.
authors.affiliation: Department of Laboratory Medicine, the People's Hospital of Leshan, Leshan, Sichuan, China.
authors.forename: X
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Laboratory Medicine, the People's Hospital of Leshan, Leshan, Sichuan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Laboratory Medicine, the People's Hospital of Leshan, Leshan, Sichuan, China.
authors.forename: Z W
authors.initials: ZW
authors.lastname: Cui
authors.affiliation: Department of Laboratory Medicine, the People's Hospital of Leshan, Leshan, Sichuan, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: L B
authors.initials: LB
authors.lastname: Gao
mesh_terms: D020413:3' Untranslated Regions; D000328:Adult; D000483:Alleles; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D016022:Case-Control Studies; D060467:Disease Resistance / Q000235:genetics* / Q000276:immunology; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D006801:Humans; D054643:INDEL Mutation; D053582:Interleukin-1alpha / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D012306:Risk
chemical_list: D020413:3' Untranslated Regions; C508584:IL1A protein, human; D053582:Interleukin-1alpha