title: Plasma Exchange and Immunoadsorption in Pediatric Inflammatory Optic Neuropathy Resistant to Corticosteroid Therapy: Four French Cases.
abstract: Steroids as a foremost therapy are widely used in pediatric optic neuritis (ON). Yet, this treatment is not standardized to date. Some children show a resistance to the classic treatment by steroids. Although plasma exchange (PE) and immunoadsorption (IA) techniques are increasingly being adopted and lead to good results in resistant cases in adult patients, very few studies have shown interest in treating ON when steroids have failed. In this study, we report four observations of children, two of whom are treated by PE and two by IA techniques, describing the treatment protocols together with the side effects observed.
authors.affiliation: Service de Neurologie Pédiatrique, Hôpital des Enfants, TSA, Toulouse, France.
authors.forename: Coralie
authors.initials: C
authors.lastname: Jacquet
authors.affiliation: Service de Néphrologie Pédiatrique, Hôpital des Enfants, TSA, Toulouse, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Garnier
authors.affiliation: Service de Neurologie Pédiatrique, Hôpital des Enfants, TSA, Toulouse, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Cheuret
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005602:France; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007163:Immunosorbent Techniques; D008297:Male; D008581:Meningitis / Q000150:complications; D008775:Methylprednisolone / Q000627:therapeutic use*; D009471:Neuromyelitis Optica / Q000150:complications / Q000628:therapy*; D009902:Optic Neuritis / Q000150:complications / Q000628:therapy*; D010661:Phenylketonurias / Q000150:complications; D010951:Plasma Exchange; D012008:Recurrence
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone