title: Management of Very Early-onset Fetal Growth Restriction: Results from 92 Consecutive Cases.
abstract: OBJECTIVE
  To evaluate management of early-onset intrauterine growth restriction (IUGR) and to define outcome according to obstetric setting.
  
  
  METHODS
  During an 11-year period (2000-2011), data of patients presenting with IUGR and preterm delivery of less than 30 weeks of gestation at a tertiary perinatal center were retrospectively reviewed.
  
  
  RESULTS
  A total of 92 pregnancies were investigated. Delivery was indicated for fetal reasons in 38 out of 92 patients. Sixteen children of our cohort died within one year post partum, out of which eight had suffered from severe early-onset IUGR causing iatrogenic preterm delivery. Concerning the fetal outcome, gestational age at delivery and antenatal exposure to corticosteroids were found to be crucial.
  
  
  CONCLUSIONS
  In some cases, respiratory distress syndrome prophylaxis and a "wait and see" approach to management in favor of a prolongation of the pregnancy might be favorable. Randomized prospective trials in early-onset IUGR with threatened preterm deliveries are needed in order to define guidelines for an individually tailored management of early-onset preterm infants.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital Schleswig-Holstein, Lübeck, Germany friederike.hoellen@uksh.de.
authors.forename: Friederike
authors.initials: F
authors.lastname: Hoellen
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital Schleswig-Holstein, Lübeck, Germany.
authors.forename: Annika
authors.initials: A
authors.lastname: Beckmann
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital Schleswig-Holstein, Lübeck, Germany.
authors.forename: Constanze
authors.initials: C
authors.lastname: Banz-Jansen
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital Schleswig-Holstein, Lübeck, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Weichert
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital Schleswig-Holstein, Lübeck, Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Rody
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital Mannheim, Mannheim, Germany.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Bohlmann
mesh_terms: D001034:Apgar Score; D036861:Delivery, Obstetric; D019468:Disease Management; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth; D012189:Retrospective Studies
keywords: Doppler sonography; Fetal growth restriction; intrauterine growth restriction; preterm delivery