title: Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans.
abstract: Candida albicans is a human fungal pathogen capable of causing lethal systemic infections. The plasma membrane plays key roles in virulence because it not only functions as a protective barrier, it also mediates dynamic functions including secretion of virulence factors, cell wall synthesis, invasive hyphal morphogenesis, endocytosis, and nutrient uptake. Consistent with this functional complexity, the plasma membrane is composed of a wide array of lipids and proteins. These components are organized into distinct domains that will be the topic of this review. Some of the plasma membrane domains that will be described are known to act as scaffolds or barriers to diffusion, such as MCC/eisosomes, septins, and sites of contact with the endoplasmic reticulum. Other zones mediate dynamic processes, including secretion, endocytosis, and a special region at hyphal tips that facilitates rapid growth. The highly organized architecture of the plasma membrane facilitates the coordination of diverse functions and promotes the pathogenesis of C. albicans.
authors.affiliation: Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, 11794-5222, USA.
authors.forename: Lois M
authors.initials: LM
authors.lastname: Douglas
authors.affiliation: Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, 11794-5222, USA. james.konopka@stonybrook.edu.
authors.forename: James B
authors.initials: JB
authors.lastname: Konopka
mesh_terms: D002176:Candida albicans / Q000254:growth & development / Q000472:pathogenicity* / Q000648:ultrastructure; D002177:Candidiasis / Q000382:microbiology; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D004705:Endocytosis / Q000502:physiology; D005656:Fungal Proteins / Q000378:metabolism; D006801:Humans; D025301:Hyphae / Q000254:growth & development / Q000378:metabolism / Q000648:ultrastructure; D008958:Models, Molecular; D014774:Virulence; D037521:Virulence Factors / Q000378:metabolism / Q000502:physiology*
chemical_list: D005656:Fungal Proteins; D037521:Virulence Factors
keywords: Candida albicans; MCC domain; eisosome; fungal pathogenesis; hyphal morphogenesis; plasma membrane; septin