title: The Muscle-Bound Heart.
abstract: Hypertrophic cardiomyopathy (HCM) is a familial cardiac disease manifested in a wide phenotype and diverse genotype and, thus, presenting unpredictable risks mainly on young adults. Extensive studies are being conducted to categorize patients and link phenotype with genotype for a better management and control of the disease with all its complications. Because the full mechanisms behind HCM are still not revealed, therapeutics are not definitive. Further research is to be conducted for the generation of a complete picture and directed therapy for HCM.
authors.affiliation: Cardiac Electrophysiology, Cardiology, Department of Internal Medicine, American University of Beirut Faculty of Medicine and Medical Center, PO Box 11-0236, Riad El-Solh, Beirut 1107 2020, Lebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut Faculty of Medicine and Medical Center, PO Box 11-0236, Riad El-Solh, Beirut 1107 2020, Lebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon. Electronic address: mr48@aub.edu.lb.
authors.forename: Marwan M
authors.initials: MM
authors.lastname: Refaat
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Akl C
authors.initials: AC
authors.lastname: Fahed
authors.affiliation: Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.
authors.forename: Sylvana
authors.initials: S
authors.lastname: Hassanieh
authors.affiliation: Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Hotait
authors.affiliation: Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Mariam
authors.initials: M
authors.lastname: Arabi
authors.affiliation: Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Hadi
authors.initials: H
authors.lastname: Skouri
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, MA, USA.
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Seidman
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, MA, USA; Division of Cardiology, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Christine E
authors.initials: CE
authors.lastname: Seidman
authors.affiliation: Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Fadi F
authors.initials: FF
authors.lastname: Bitar
authors.affiliation: Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.
authors.forename: Georges
authors.initials: G
authors.lastname: Nemer
mesh_terms: D000328:Adult; D001281:Atrial Fibrillation; D002312:Cardiomyopathy, Hypertrophic; D017115:Catheter Ablation; D006801:Humans; D008297:Male; D010375:Pedigree
keywords: Genotype; Hypertrophic cardiomyopathy; Left ventricle; Muscle-bound heart; Phenotype