title: Stem Cell Therapy for the Treatment of Hip Osteonecrosis: A 30-Year Review of Progress.
abstract: Avascular necrosis of the femoral head is caused by a multitude of etiologic factors and is associated with collapse with a risk of hip arthroplasty in younger populations. A focus on early disease management with the use of stem cells was proposed as early as 1985 by the senior author (PH). We undertook a systematic review of the medical literature to examine the progress in cell therapy during the last 30 years for the treatment of early stage osteonecrosis.
authors.affiliation: Department of Orthopaedic Surgery, University Paris East (UPEC), Hôpital Henri Mondor, Creteil, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Hernigou
authors.affiliation: Department of Orthopaedic Surgery, University Paris East (UPEC), Hôpital Henri Mondor, Creteil, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Trousselier
authors.affiliation: Department of Orthopaedic Surgery, University Paris East (UPEC), Hôpital Henri Mondor, Creteil, France.
authors.forename: François
authors.initials: F
authors.lastname: Roubineau
authors.affiliation: Department of Orthopaedic Surgery, University Paris East (UPEC), Hôpital Henri Mondor, Creteil, France.
authors.forename: Charlie
authors.initials: C
authors.lastname: Bouthors
authors.affiliation: EFS Cell Therapy Facility, University Paris East (UPEC), Hôpital Henri Mondor, Creteil, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chevallier
authors.affiliation: EFS Cell Therapy Facility, University Paris East (UPEC), Hôpital Henri Mondor, Creteil, France.
authors.forename: Helene
authors.initials: H
authors.lastname: Rouard
authors.affiliation: Department of Orthopaedic Surgery, University Paris East (UPEC), Hôpital Henri Mondor, Creteil, France.
authors.forename: Charles-Henri
authors.initials: CH
authors.lastname: Flouzat-Lachaniette
mesh_terms: D064987:Cell- and Tissue-Based Therapy; D005270:Femur Head / Q000601:surgery*; D005271:Femur Head Necrosis / Q000601:surgery*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D023822:Tissue Engineering
keywords: Cell therapy; Hip; Mesenchymal stromal cells; Osteonecrosis; Tissue engineering