title: Comparison of Postoperative Morphine Requirements in Renal Donors and Patients With Renal Carcinoma Undergoing Laparoscopic Nephrectomy.
abstract: OBJECTIVE
  The objective of this study was to evaluate postoperative pain intensity and morphine consumption between living renal donors and patients with renal cell carcinoma undergoing laparoscopic nephrectomy.
  
  
  METHODS
  The clinical trial enrolled 25 living renal donors and 25 patients with renal cell carcinoma undergoing laparoscopic nephrectomy. All underwent similar surgical procedures under general anesthesia. After surgery, morphine patient-controlled analgesia (PCA) was applied to all of them. Data including demographics, surgical details, postoperative morphine consumption, visual analog scale (VAS) scores at rest and during coughing at postoperative 0.5, 2, 4, 8, 12, 24 and 48 hours, side effects, and overall satisfaction degree were compared between the 2 groups.
  
  
  RESULTS
  Donors received more intravenous doses of morphine than patients. VAS scores at 2 and 4 hours at rest and during coughing after extubation were significantly higher in donors. The overall satisfaction degree was higher in patients.
  
  
  CONCLUSIONS
  Living-renal donors suffer more pain and are associated with more morphine consumption than patients with cancer.
authors.affiliation: Department of Urology, the First Hospital of Jilin University, Changchun, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, the First Hospital of Jilin University, Changchun, China.
authors.forename: H
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Urology, the First Hospital of Jilin University, Changchun, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Department of Anesthesiology, the First Hospital of Jilin University, Changchun, China. Electronic address: lilyly12345@163.com.
authors.forename: N
authors.initials: N
authors.lastname: Wang
mesh_terms: D000328:Adult; D016058:Analgesia, Patient-Controlled / Q000706:statistics & numerical data; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D002292:Carcinoma, Renal Cell / Q000601:surgery*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000601:surgery*; D010535:Laparoscopy; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage*; D009392:Nephrectomy / Q000009:adverse effects* / Q000379:methods; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology; D011184:Postoperative Period
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine