title: Multicentric myofibromatosis presenting as a large congenital eyelid myofibroma.
abstract: Infantile myofibromatosis is a rare mesenchymal neoplasm that commonly involves the head and neck but rarely the eyelid. We report the case of a newborn boy referred for evaluation of a left eyelid lesion that occluded the visual axis. Urgent biopsy was performed to evaluate for malignancy. Histopathologic analysis demonstrated myofibroma. Although these lesions have been reported to regress spontaneously, debulking surgery was performed to prevent sensory or anisometropic amblyopia. Follow-up systemic evaluation revealed numerous subcutaneous and deep soft tissue lesions. There was no visceral involvement.
authors.affiliation: Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
authors.forename: Peter W
authors.initials: PW
authors.lastname: MacIntosh
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
authors.forename: Seanna R
authors.initials: SR
authors.lastname: Grob
authors.affiliation: Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Stagner
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Pediatric Ophthalmology and Strabismus, Massachusetts Eye and Ear Infirmary.
authors.forename: Melanie A
authors.initials: MA
authors.lastname: Kazlas
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary.
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Jakobiec
authors.affiliation: Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Electronic address: Michael_Yoon@meei.harvard.edu.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Yoon
authors.affiliation: Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
authors.forename: Nahyoung Grace
authors.initials: NG
authors.lastname: Lee
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D005142:Eyelid Neoplasms / Q000151:congenital / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D047708:Myofibroma / Q000151:congenital / Q000175:diagnosis* / Q000378:metabolism; D018224:Myofibromatosis / Q000151:congenital* / Q000175:diagnosis / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins