title: Nigella sativa and its active constituent thymoquinone in oral health.
abstract: In this review, we summarized published reports that investigated the role of Nigella sativa (NS) and its active constituent, thymoquinone (TQ) in oral health and disease management. The literature studies were preliminary and scanty, but the results revealed that black seed plants have a potential therapeutic effect for oral and dental diseases. Such results are encouraging for the incorporation of these plants in dental therapeutics and hygiene products. However, further detailed preclinical and clinical studies at the cellular and molecular levels are required to investigate the mechanisms of action of NS and its constituents, particularly TQ.
authors.affiliation: Department of Oral Diagnostic Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail. safia_attas@hotmail.com.
authors.forename: Safia A
authors.initials: SA
authors.lastname: Al-Attass
authors.forename: Fat'heya M
authors.initials: FM
authors.lastname: Zahran
authors.forename: Shereen A
authors.initials: SA
authors.lastname: Turkistany
mesh_terms: D016227:Benzoquinones / Q000627:therapeutic use*; D003731:Dental Caries / Q000188:drug therapy; D003788:Dental Pulp Diseases / Q000188:drug therapy; D005891:Gingivitis / Q000188:drug therapy; D006801:Humans; D009059:Mouth Diseases / Q000188:drug therapy*; D031881:Nigella sativa; D009909:Oral Health; D019226:Oral Ulcer / Q000188:drug therapy; D010518:Periodontitis / Q000188:drug therapy; D010936:Plant Extracts / Q000627:therapeutic use*; D012639:Seeds; D013280:Stomatitis / Q000188:drug therapy; D014076:Tooth Diseases / Q000188:drug therapy*
chemical_list: D016227:Benzoquinones; D010936:Plant Extracts; C003466:thymoquinone