title: State of the Art of Combined Heart-Lung Transplantation for Advanced Cardiac and Pulmonary Dysfunction.
abstract: Over the last several decades, significant advances and improvements in care of transplant patients have resulted in markedly improved outcomes. A number of options are available for patients with advanced cardiopulmonary dysfunction requiring transplantation. There is a debate about when isolated heart or isolated lung transplantation is no longer possible or advisable and combined heart-lung transplantation is justified. Organ availability and allocation severely limit the latter option to very few well-selected patients. We review practice patterns, trends, and outcomes after triple-organ heart-lung transplant (HLTx) worldwide, as well as our own experience with heart-lung transplant in the modern era.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue/Mail Stop J4-1, Cleveland, OH, 44195, USA.|Department of Quantitative Health Sciences, Research Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Jay J
authors.initials: JJ
authors.lastname: Idrees
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue/Mail Stop J4-1, Cleveland, OH, 44195, USA. petterg@ccf.org.|Department of Quantitative Health Sciences, Research Institute, Cleveland Clinic, Cleveland, OH, USA. petterg@ccf.org.
authors.forename: Gösta B
authors.initials: GB
authors.lastname: Pettersson
mesh_terms: D006333:Heart Failure / Q000601:surgery; D016041:Heart-Lung Transplantation / Q000379:methods* / Q000401:mortality / Q000639:trends*; D006801:Humans; D018579:Patient Selection; D011183:Postoperative Complications; D012131:Respiratory Insufficiency / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome; D014481:United States
keywords: Cardiac and pulmonary dysfunction; ECMO; Eisenmenger; Heart failure; Heart-lung transplant; Only option; Pulmonary hypertension