title: Uterine Adenosarcoma.
abstract: Müllerian adenosarcoma is an uncommon biphasic tumor composed of malignant stromal and benign epithelial components. Morphologically, adenosarcoma is characterized by a broad leaflike architecture, reminiscent of phyllodes tumors of the breast. Periglandular cuffing of the stromal cells around the compressed or cystically dilated glands is characteristic. The mesenchymal component is typically a low-grade spindle cell sarcoma, whereas the epithelial counterpart is commonly endometrioid with frequent squamous or mucinous metaplasia and may, in some circumstances, show mild to moderate atypia. In all cases, it is important to assess for the presence of sarcomatous overgrowth and myometrial invasion, which are the prognostic factors. In this brief review, we present the clinical, histopathologic, and immunohistochemical features of adenosarcoma, as well as updates on the molecular biology of this neoplasm.
authors.affiliation: From the Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, Massachusetts (Drs Pinto and Howitt);
authors.forename: Andre
authors.initials: A
authors.lastname: Pinto
authors.affiliation: and Harvard Medical School, Boston (Dr Howitt).
authors.forename: Brooke
authors.initials: B
authors.lastname: Howitt
mesh_terms: D018195:Adenosarcoma / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D005784:Gene Amplification; D006801:Humans; D007150:Immunohistochemistry; D018200:Mixed Tumor, Mullerian / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D025202:Molecular Diagnostic Techniques; D009154:Mutation; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D017410:Practice Guidelines as Topic; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D014599:Uterus / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000075924:X-linked Nuclear Protein
chemical_list: C088831:MYBL1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D004265:DNA Helicases; C092332:ATRX protein, human; D000075924:X-linked Nuclear Protein