title: Recent Advances on Luminescent Enhancement-Based Porous Silicon Biosensors.
abstract: Luminescence-based detection paradigms have key advantages over other optical platforms such as absorbance, reflectance or interferometric based detection. However, autofluorescence, low quantum yield and lack of photostability of the fluorophore or emitting molecule are still performance-limiting factors. Recent research has shown the need for enhanced luminescence-based detection to overcome these drawbacks while at the same time improving the sensitivity, selectivity and reducing the detection limits of optical sensors and biosensors. Nanostructures have been reported to significantly improve the spectral properties of the emitting molecules. These structures offer unique electrical, optic and magnetic properties which may be used to tailor the surrounding electrical field of the emitter. Here, the main principles behind luminescence and luminescence enhancement-based detections are reviewed, with an emphasis on europium complexes as the emitting molecule. An overview of the optical porous silicon microcavity (pSiMC) as a biosensing platform and recent proof-of-concept examples on enhanced luminescence-based detection using pSiMCs are provided and discussed.
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.|Research Centre for Chemistry, Indonesian Institute of Sciences, PUSPIPTEK, Serpong, Tangerang, Banten, 15314, Indonesia.
authors.forename: S N Aisyiyah
authors.initials: SN
authors.lastname: Jenie
authors.affiliation: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, 5000, Australia.
authors.forename: Sally E
authors.initials: SE
authors.lastname: Plush
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia. nico.voelcker@unisa.edu.au.|, GPO Box 2471, Adelaide, South Australia, 5001, Australia. nico.voelcker@unisa.edu.au.
authors.forename: Nicolas H
authors.initials: NH
authors.lastname: Voelcker
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D049449:Luminescence; D008280:Magnetics / Q000379:methods; D016062:Porosity; D012825:Silicon / Q000737:chemistry*
chemical_list: D012825:Silicon
keywords: biosensors; europium; luminescence enhancement; microcavity; porous silicon