title: Synthesis and Bioactivities of Novel Pyrazole Oxime Derivatives Containing a 5-Trifluoromethylpyridyl Moiety.
abstract: In this study, in order to find novel biologically active pyrazole oxime compounds, a series of pyrazole oxime derivatives containing a 5-trifluoromethylpyridyl moiety were synthesized. Preliminary bioassays indicated that most title compounds were found to display good to excellent acaricidal activity against Tetranychus cinnabarinus at a concentration of 200 μg/mL, and some designed compounds still showed excellent acaricidal activity against Tetranychus cinnabarinus at the concentration of 10 μg/mL, especially since the inhibition rates of compounds 8e, 8f, 8l, 8m, 8n, 8p, and 8q were all 100.00%. Interestingly, some target compounds exhibited moderate to good insecticidal activities against Plutella xylostella and Aphis craccivora at a concentration of 200 μg/mL; furthermore, compounds 8e and 8l possessed outstanding insecticidal activities against Plutella xylostella under the concentration of 50 μg/mL.
authors.affiliation: College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China. daihong_2015@aliyun.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Dai
authors.affiliation: College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China. 15642891665@163.com.
authors.forename: Jia
authors.initials: J
authors.lastname: Chen
authors.affiliation: Nantong Fengtian Chemical Industry Co. Ltd., Nantong 226005, China. leehomer@sina.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Chemical and Biological Engineering, Nantong Vocational University, Nantong 226007, China. dbj20110802@163.com.
authors.forename: Baojiang
authors.initials: B
authors.lastname: Dai
authors.affiliation: College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China. gaohbhe2015@aliyun.com.
authors.forename: Haibing
authors.initials: H
authors.lastname: He
authors.affiliation: College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China. fyuan6586@aliyun.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.affiliation: College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China. syj@ntu.edu.cn.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Shi
mesh_terms: D056810:Acaricides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001042:Aphids / Q000187:drug effects; D015195:Drug Design; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009036:Moths / Q000187:drug effects; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D040102:Tetranychidae / Q000187:drug effects
chemical_list: D056810:Acaricides; D007306:Insecticides; D010091:Oximes; D011720:Pyrazoles
keywords: 5-trifluoromethylpyridyl; bioactivity; pyrazole oxime; synthesis