title: Mast Cell Concentrations in Peripheral and Central Giant Cell Granulomas: Is there any Angiogenetic Role?
abstract: BACKGROUND
  In the maxillofacial region, giant cell granulomas occur in 2 clinical forms, central and peripheral. Despite histopathological similarity between these 2 forms totally different clinical behaviors have been reported. The present study was undertaken to compare mast cell and vascular concentrations in these pathologic lesions.
  
  
  METHODS
  In this cross-sectional descriptive study, 20 pathological samples of central giant cell granuloma (CGCG) and 20 samples of peripheral giant cell granuloma (PGCG) were selected and examined through toluidine blue staining for mast cell assessment and immunohistochemical staining by VEGEF antibody for comparing the number of mast cells. T-test, chi-squared test and backward multivariate linear regression were used for statistical analysis using SPSS 20. Statistical significance was set at P<0.05.
  
  
  RESULTS
  This study showed significantly greater VEGF expression and mast cell concentrations in CGCG compared to PGCG cases. Also there was a significant correlation between VEGF expression and the concentration of mast cells. No relation was found between age, sex and site of the lesion and concentration of mast cells or VEGF expression.
  
  
  CONCLUSIONS
  It is feasible that higher concentrations of mast cells in CGCG versus PGCG samples might lead to more aggressive clinical behavior via vascular proliferation and angiogenesis. However, other biologic mechanisms should be considered in this situation.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Dental Branch of Tehran, Islamic Azad University, Tehran, Iran E-mail : ferial2002@yahoo.com.
authors.forename: Sareh
authors.initials: S
authors.lastname: Farhadi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Shahsavari
authors.forename: Ferial
authors.initials: F
authors.lastname: Taleghani
authors.forename: Elaheh
authors.initials: E
authors.lastname: Komasi
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005500:Follow-Up Studies; D006101:Granuloma, Giant Cell / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008407:Mast Cells / Q000378:metabolism / Q000473:pathology*; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A