title: A Case of an 11-year-old With Cough, Diarrhea, and Findings of Concern in His Lungs and Spleen.
abstract: This is the case of a previously healthy, 11-year-old male of Indian descent who presented to the emergency department with a 2-month history of nausea, vomiting, diarrhea, fatigue, cough, and 7-lb weight loss. Acutely, he developed 5 days of fever as high as 39.4°C. He had a remote travel history to the Middle East. On physical examination, he was febrile and tachycardic, was thin but otherwise had a normal examination. His inflammatory markers were elevated: erythrocyte sedimentation rate was 93 mm/hour and his C-reactive protein was 25.4 mg/L. A complete blood count revealed a white blood cell count of 17,000 × 10(3)/µL with increased bands. His hemoglobin level was 8.8 g/dL with a mean corpuscular volume of 81 fl. Platelets were 556 × 10(3)/µL. A chest radiograph was concerning for a cavitary lung lesion and an abdominal ultrasound revealed multiple hypoechoic lesions in his spleen. Our panel of experts reviews his case and examines the workup of this patient with diverse symptoms and focal findings on chest radiograph and abdominal ultrasound.
authors.affiliation: Department of Pediatrics and jbdarby@bcm.edu.
authors.forename: John B
authors.initials: JB
authors.lastname: Darby
authors.affiliation: Department of Pediatrics and.
authors.forename: Chris A
authors.initials: CA
authors.lastname: Rees
authors.affiliation: Department of Pediatrics and.
authors.forename: Claire E
authors.initials: CE
authors.lastname: Bocchini
authors.affiliation: Department of Pediatrics and.
authors.forename: Andrea T
authors.initials: AT
authors.lastname: Cruz
authors.affiliation: Department of Pediatrics and.
authors.forename: Richard
authors.initials: R
authors.lastname: Kellermayer
authors.affiliation: Pathology, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas.
authors.forename: Milton J
authors.initials: MJ
authors.lastname: Finegold
authors.affiliation: Department of Pediatrics and.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Barlow
mesh_terms: D002648:Child; D003371:Cough / Q000209:etiology*; D003424:Crohn Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000209:etiology*; D005221:Fatigue / Q000209:etiology; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D007239:Infections / Q000175:diagnosis; D000069285:Infliximab / Q000627:therapeutic use; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D009325:Nausea / Q000209:etiology; D011859:Radiography; D013154:Spleen / Q000000981:diagnostic imaging*; D014463:Ultrasonography; D014839:Vomiting / Q000209:etiology
chemical_list: D005765:Gastrointestinal Agents; D000069285:Infliximab