title: [Changes in small airway function in rhinitis without asthma].
abstract: OBJECTIVE
  Observe the changes of small airway function in patients with rhinitis but without asthma and/or lower airway symptoms.
  
  
  METHODS
  Between June 2008 and December 2012, we recruited 903 subjects, including 377 with allergic rhinitis (AR), 262 with non-allergic rhinitis (NAR) and 264 healthy subjects. All subjects underwent meticulous history taking, nasal examination, allergen skin prick test, blood routine test, serum total immunoglobin E assay, pulmonary ventilation function test and bronchial challenge test.
  
  
  RESULTS
  The indices of FEV1/FVC%, MEF25pred% and MMEFpred% were lower in AR group than in the control group (P < 0.05). The indices of FEV1/FVC, MMEFpred%, MEF25pred% and MEF50pred% were also lower in NAR group than in the control group (P < 0.05). According to the FVCpred% and FEV1pred%, there were no differences between rhinitis group and the control group (P > 0.05). The positive rate of airway hyperresponsiveness(AHR) in AR group and in NAR group was 12.2%, 6.1% respectively. Indices of small airway function were all lower in the AHR group than NAHR group in rhinitis.
  
  
  CONCLUSIONS
  Compared with healthy controls, small airway function in patients with rhinitis has apparent changes, part of rhinitis patients has AHR, and is associated with small airway function changes.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Ji
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Wang
authors.forename: Xu
authors.initials: X
authors.lastname: Shi
authors.forename: Weijie
authors.initials: W
authors.lastname: Guan
authors.forename: Kunmin
authors.initials: K
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Fei
authors.initials: F
authors.lastname: Xue
authors.forename: Manjie
authors.initials: M
authors.lastname: Jiang
authors.forename: You
authors.initials: Y
authors.lastname: Cheng
authors.forename: Tianyou
authors.initials: T
authors.lastname: Wang
authors.forename: Nanshan
authors.initials: N
authors.lastname: Zhong
mesh_terms: D001249:Asthma; D016022:Case-Control Studies; D006801:Humans; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000503:physiopathology*; D012220:Rhinitis / Q000503:physiopathology*; D065631:Rhinitis, Allergic / Q000503:physiopathology*; D012882:Skin Tests