title: Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients.
abstract: Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes.
authors.affiliation: Department of Psychiatry, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.
authors.forename: Hamdy
authors.initials: H
authors.lastname: Moselhy
authors.affiliation: University of New South Wales, Australia; Ingham Institute, School of Medicine, University of Western Sydney, Sydney, NSW, Australia.
authors.forename: Valsamma
authors.initials: V
authors.lastname: Eapen
authors.affiliation: Department of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.
authors.forename: Nadia A
authors.initials: NA
authors.lastname: Akawi
authors.affiliation: Al-Ain Hospital, Al-Ain, United Arab Emirates.
authors.forename: Ali
authors.initials: A
authors.lastname: Younis
authors.affiliation: Al-Ain Hospital, Al-Ain, United Arab Emirates.
authors.forename: Badr
authors.initials: B
authors.lastname: Salih
authors.affiliation: Department of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.
authors.forename: Aws R
authors.initials: AR
authors.lastname: Othman
authors.affiliation: Department of Psychiatry, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.
authors.forename: Said
authors.initials: S
authors.lastname: Yousef
authors.affiliation: Ingham Institute, School of Medicine, University of Western Sydney, Sydney, NSW, Australia.
authors.forename: Raymond A
authors.initials: RA
authors.lastname: Clarke
authors.affiliation: Department of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.
authors.forename: Bassam R
authors.initials: BR
authors.lastname: Ali
keywords: DISC1; Genetics; NRG3; PDLIM5; PICK1; Schizophrenia