title: The genetics of neuroticism and human values.
abstract: Human values and personality have been shown to share genetic variance in twin studies. However, there is a lack of evidence about the genetic components of this association. This study examined the interplay between genes, values and personality in the case of neuroticism, because polygenic scores were available for this personality trait. First, we replicated prior evidence of a positive association between the polygenic neuroticism score (PNS) and neuroticism. Second, we found that the PNS was significantly associated with the whole human value space in a sinusoidal waveform that was consistent with Schwartz's circular model of human values. These results suggest that it is useful to consider human values in the analyses of genetic contributions to personality traits. They also pave the way for an investigation of the biological mechanisms contributing to human value orientations.
authors.affiliation: School of Psychology, Cardiff University, Cardiff, UK.
authors.forename: George
authors.initials: G
authors.lastname: Zacharopoulos
authors.affiliation: School of Psychology, Cardiff University, Cardiff, UK.|Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.|MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Lancaster
authors.affiliation: School of Psychology, Cardiff University, Cardiff, UK.
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Maio
authors.affiliation: School of Psychology, Cardiff University, Cardiff, UK.|Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.|MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
authors.forename: David E J
authors.initials: DE
authors.lastname: Linden
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D000075384:Neuroticism; D010551:Personality / Q000235:genetics; D012945:Social Values
keywords: Genetics; human values; neuroticism; personality; polygenic score