title: [The connection between LINE-1 retrotransposition and human tumorigenesis].
abstract: LINE-1 is the only currently known active autonomous transposon in humans with an estimated 500 000 copies representing 17% of the human genome. LINE-1 propagates itself through a process called retrotransposition, which includes transcription and reverstranscription, to produce new DNA copies. The new produced DNA copies can integrate into new genomic loci. The insertion of LINE-1 is able to cause genetic instability by affecting the expression or regulation of the nearby genes, thus causing dozens of genetic diseases or tumors. In this review, we summarize the recent research progress on the connection between LINE-1 retrotransposition and human tumorigenesis, which might shed light on the biology mechanisms and treatment of the tumorigenesis.
authors.affiliation: Department of Immunology, Institute of Medicinal Biotechnology, Chinese academy of Medical Sciences &
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
authors.forename: Jin-hui
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Department of Immunology, Institute of Medicinal Biotechnology, Chinese academy of Medical Sciences &
authors.forename: Xiao-yu
authors.initials: XY
authors.lastname: Li
authors.affiliation: Department of Immunology, Institute of Medicinal Biotechnology, Chinese academy of Medical Sciences &
authors.forename: Shan
authors.initials: S
authors.lastname: Cen
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D020084:Long Interspersed Nucleotide Elements / Q000235:genetics*; D008957:Models, Genetic; D016254:Mutagenesis, Insertional; D048348:Reverse Transcription