title: Enlarging Pancreatic Schwannoma: A Case Report and Review of the Literature.
abstract: A 72-year-old female presented with dyspepsia for 2 years and an incidental mass in the head of the pancreas on abdominal computed tomography (CT) scan. Patient had multiple negative endoscopic ultrasound guided biopsies. She was followed up for 3 years with serial imaging until an abdominal CT scan showed an increase in size of the pancreatic mass. Physical examination was unremarkable. Laboratory tests including tumor markers were normal. Given the enlarging size of the mass and its impingement on the portal vein, the consensus was to proceed with surgery. Histology revealed a 3.5 cm mass showing a spindle cell neoplasm with mild atypia. The lesion was well defined and nerve tissue was noted at the periphery. On immuno-stains, the spindle cells were positive for S-100 protein and negative for pan-cytokeratin, CD-34, CD-117, smooth muscle actin and Melan A, consistent with the diagnosis of a pancreatic schwannoma.
authors.affiliation: Rutgers-New Jersey Medical School , Newark, NJ.
authors.forename: Narjust
authors.initials: N
authors.lastname: Duma
authors.affiliation: Rutgers-New Jersey Medical School , Newark, NJ.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Ramirez
authors.affiliation: Hackensack University Medical Center , Hackensack, NJ, USA.
authors.forename: Gloria
authors.initials: G
authors.lastname: Young
authors.affiliation: Hackensack University Medical Center , Hackensack, NJ, USA.
authors.forename: George
authors.initials: G
authors.lastname: Nikias
authors.affiliation: Hackensack University Medical Center , Hackensack, NJ, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Karpeh
authors.affiliation: Hackensack University Medical Center , Hackensack, NJ, USA.
authors.forename: Zubin M
authors.initials: ZM
authors.lastname: Bamboat
keywords: Pancreatic schwannoma; nerve tissue tumors; neurilemmomas; pancreatic mass