title: A Multifunctional Theranostic Nanoagent for Dual-Mode Image-Guided HIFU/Chemo- Synergistic Cancer Therapy.
abstract: High-intensity focused ultrasound (HIFU) is deemed to be a promising noninvasive therapeutic modality for cancers as well as non-neoplastic diseases. However, the accuracy of the technique in the diagnosis and treatment of tumors remains unsatisfactory. HIFU, when combined with multifunctional synergistic agents (SAs), has the potential to be of greater diagnostic and therapeutic efficacy. Here we describe a smart and multifunctional hollow mesoporous Prussian blue (HMPBs) theranostic nanoplatform, the hollow structure of which is capable of encapsulating doxorubicin (DOX) and perfluorohexane (HMPBs-DOX/PFH). In vitro and in vivo studies validated that HMPBs-DOX/PFH can be used as an amplifiable dual-mode imaging contrast agent, which can simultaneously enhance ultrasound (US) and photoacoustic (PA) imaging for guiding and monitoring tumor therapy. When exposed to HIFU, this versatile HMPBs-DOX/PFH agent could increase the cavitation effect and use lower HIFU intensity to achieve coagulative necrosis. Furthermore, it significantly accelerated the release of DOX thereby enhancing chemotherapeutic efficacy and avoiding systemic side effects of the drug. Such a novel theranostic nanoplatform is expected to integrate dual-mode guided imaging with greater therapeutic efficacy and fewer side effects and is very promising for the noninvasive synergistic tumor therapy.
authors.affiliation: 1. Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, 400010, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: 2. State Key Laboratory of High-Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Cai
authors.affiliation: 1. Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, 400010, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: 1. Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, 400010, China.
authors.forename: Ronghui
authors.initials: R
authors.lastname: Wang
authors.affiliation: 1. Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, 400010, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Xu
authors.affiliation: 1. Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, 400010, China.
authors.forename: Yuanzhi
authors.initials: Y
authors.lastname: Yao
authors.affiliation: 1. Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, 400010, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Hao
authors.affiliation: 1. Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, 400010, China.
authors.forename: Danli
authors.initials: D
authors.lastname: Sheng
authors.affiliation: 2. State Key Laboratory of High-Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences.
authors.forename: Hangrong
authors.initials: H
authors.lastname: Chen
authors.affiliation: 1. Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, 400010, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: 1. Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, 400010, China.
authors.forename: Yuanyi
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D002417:Cattle; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy / Q000379:methods*; D004195:Disease Models, Animal; D004317:Doxorubicin; D004337:Drug Carriers / Q000493:pharmacokinetics*; D005260:Female; D005295:Ferrocyanides / Q000378:metabolism; D005466:Fluorocarbons; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D008099:Liver / Q000473:pathology; D053758:Nanoparticles; D061848:Optical Imaging; D061088:Photoacoustic Techniques; D011817:Rabbits; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005295:Ferrocyanides; D005466:Fluorocarbons; D004317:Doxorubicin; C078626:perflexane; C000170:ferric ferrocyanide
keywords: High-intensity focused ultrasound; Hollow mesoporous Prussian blue; Phase transformation; Photoacoustic imaging; Theranostics.