title: Sniping the scout: Targeting the key molecules in dendritic cell functions for treatment of autoimmune diseases.
abstract: Dendritic cells (DCs) are a power tool for manipulating immune system. They play important roles in the induction of immunity as well as inducing intrathymic and peripheral tolerance. After generated from stem cells in the bone marrow, DCs traffic to the peripheral tissues, where they capture and process antigens, express lymphocyte co-stimulators, migrate to the secondary lymph organs and present the processed antigen to naive T cells to either activate or tolerize them. These processes are modulated subtly and influenced by various factors. Aberrant regulation of the processes may cause autoimmunity. Investigation into the biology of DCs and the molecules and mechanisms that regulate them helps us understanding the pathogenesis of autoimmune diseases and reveals numerous steps for pharmacological manipulation. In this review, we made a sketch line of the critical events of DC biology that are potential pharmacologic targets for the treatment of autoimmune diseases.
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China; Institute of Clinical Immunology, Academy of Orthopedics, Guangdong Province, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.affiliation: Hospital of South China Normal University, Guangzhou, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China; Institute of Clinical Immunology, Academy of Orthopedics, Guangdong Province, China. Electronic address: sunew@smu.edu.cn.
authors.forename: Erwei
authors.initials: E
authors.lastname: Sun
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D015551:Autoimmunity; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans
keywords: Apigenin (PubChem CID: 5280443); Aspirin (PubChem CID: 2244); Auranofin (PubChem CID: 24199313); Autoimmune diseases; Butyric acid (PubChem CID: 264); Chloroquine (PubChem CID: 2719); Chrysin (PubChem CID: 5281607); Cyclosporin a (PubChem CID: 5284373); Dendritic cells; Dexamethasone (PubChem CID: 5743); FTY720 (PubChem CID: 107969); Fostamatinib (PubChem CID: 11671467); Fumarates (PubChem CID: 5281069); Glatiramer acetate (PubChem CID: 3081884); IL-10 (PubChem CID: 146070); Leflunomide (PubChem CID: 3899); Mycophenolate mofetil (PubChem CID: 5281078); N-acetyl-L-cysteine (PubChem CID: 12035); Oenothein B (PubChem CID: 16132398); Quercetin (PubChem CID: 5280343); Rapamycin (PubChem CID: 5284616); Rheumatoid arthritis; Rosiglitazone (PubChem CID: 77999); Sanglifehrin a (PubChem CID: 5388925); Sunitinib (PubChem CID: 5329102); Systemic lupus erythematosus; T helper; TGF-β (PubChem CID: 56842206); Tacrolimus (PubChem CID: 445643); Tofacitinib (PubChem CID: 9926791); Trichostatin A (PubChem CID: 444732); Triptolide (PubChem CID: 107985); Troglitazone (PubChem CID: 5591); Vasoactive intestinal peptide (PubChem CID: 16129679); Vitamin D3 (PubChem CID: 5280795)