title: Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China.
abstract: Elevated LDL-C/HDL-C ratio has been shown to be a marker of lipid metabolism as well as a good predictor of coronary artery disease (CAD). Thus, the aim of this study was to investigate whether the LDL-C/HDL-C ratio is useful for detecting cardiovascular disease (CVD) risk factors in general healthy Uygur adults in Xinjiang. A total of 4047 Uygur subjects aged ≥35 years were selected from the Cardiovascular Risk Survey (CRS) study which was carried out from October 2007 to March 2010. Anthropometric data, blood pressure, lipid profile and fasting glucose were measured in all participants. The prevalence, sensitivity, specificity and distance on the receiver operating characteristic (ROC) curve of each LDL-C/HDL-C ratio were calculated. The prevalence of high LDL-C and low HDL-C cholesterol was high and positively correlated with higher LDL-C/HDL-C ratio in the Uygur population. In both men and women, we detected a slight apparent trend of high prevalence of hypertension and hypercholesterolemia with higher LDL-C/HDL-C ratio. Our study also demonstrated that the discriminatory power of the LDL-C/HDL-C ratio for CVD risk factors was slightly stronger in men than in women. Analysis of the shortest distance in the ROC curves for hypertension, dyslipidemia, diabetes, or ≥two of these risk factors suggested a LDL-C/HDL-C ratio cutoff of 2.5 for both men and women. The results of this study showed that a LDL-C/HDL-C ratio cut-off of 2.5 might be used as the predictive marker to detect CVD risk factors among Uygur adults in Xinjiang.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. chenqj0920@163.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China. chenqj0920@163.com.
authors.forename: Qing-Jie
authors.initials: QJ
authors.lastname: Chen
authors.affiliation: Department of Cardiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China. 15999168372@139.com.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Lai
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China. chenbangdang@126.com.|Clinical Research Institute of Xinjiang Medical University, Urumqi 830054, China. chenbangdang@126.com.
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. lixm505@163.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China. lixm505@163.com.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. zhaihui1985@126.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China. zhaihui1985@126.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhai
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. hechunhuiyisheng@163.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China. hechunhuiyisheng@163.com.
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: He
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. parker1985@sina.com.|Department of Cardiology, People's Hospital of Shaanxi Province, Xian 710000, China. parker1985@sina.com.
authors.forename: Shuo
authors.initials: S
authors.lastname: Pan
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. luojunyi3130@126.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China. luojunyi3130@126.com.
authors.forename: Jun-Yi
authors.initials: JY
authors.lastname: Luo
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. gaojing1110@126.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China. gaojing1110@126.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China. fenliu82@163.com.|Clinical Research Institute of Xinjiang Medical University, Urumqi 830054, China. fenliu82@163.com.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. yangyn5126@163.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China. yangyn5126@163.com.
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. myt-xj@163.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China. myt-xj@163.com.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Yang
mesh_terms: D000328:Adult; D000886:Anthropometry; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology*; D002681:China / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL
keywords: LDL-C-to-HDL-C ratio; Uygur adults; Xinjiang; cardiovascular disease risk factors; cutoff