title: Short-term effects of oral dronedarone administration on cardiac function, blood pressure and electrocardiogram in conscious telemetry dogs.
abstract: Dronedarone is a multichannel blocking antiarrhythmic drug that has been used for management of atrial fibrillation in humans, but the data in veterinary medicine are inadequate. The objective of this study was to determine the short-term effects of oral dronedarone on cardiac inotropy and lusitropy, blood pressure and electrocardiogram (ECG) in healthy dogs. A total of 6 beagle dogs were instrumented with telemetry units and sono-micrometry crystals to obtain left ventricular pressure-volume relationship, mean blood pressure (MBP) and ECG. Dogs were given orally dronedarone (20 mg/kg, twice per day) for 7 days. All parameters were obtained hourly at 4-8 hr after the first dose and at 12-, 96- (day 4) and 168-hr (day 7) after dosing. The results showed that dronedarone had no effect on inotropy and lusitropy, while it significantly lengthened PQ interval (P<0.001) and lowered MBP (P<0.05). Dronedarone also tended to reduce cardiac output (P=0.237) and heart rate (P=0.057). These results suggested that short-term effects of oral dronedarone administration at a dose of 20 mg/kg, twice per day, produced negative dromotropy with minimal effect on cardiac function in conscious dogs.
authors.affiliation: Graduate Student in the Program of Animal Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Nakkawee
authors.initials: N
authors.lastname: Saengklub
authors.forename: Brad
authors.initials: B
authors.lastname: Youngblood
authors.forename: Carlos
authors.initials: C
authors.lastname: Del Rio
authors.forename: Suwanakiet
authors.initials: S
authors.lastname: Sawangkoon
authors.forename: Robert L
authors.initials: RL
authors.lastname: Hamlin
authors.forename: Anusak
authors.initials: A
authors.lastname: Kijtawornrat
mesh_terms: D000284:Administration, Oral; D000638:Amiodarone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs / Q000502:physiology; D000077764:Dronedarone; D004562:Electrocardiography / Q000187:drug effects / Q000662:veterinary*; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D008297:Male; D013686:Telemetry / Q000379:methods / Q000662:veterinary*
chemical_list: D000889:Anti-Arrhythmia Agents; D000077764:Dronedarone; D000638:Amiodarone