title: A case report of severe panhypopituitarism in a newborn delivered by a women with Turner syndrome.
abstract: Turner syndrome (TS) is a congenital disease caused by absence or structural abnormalities of sex chromosomes resulting in gonadal dysgenesis. Spontaneous pregnancies occur in 2-8% of patients, especially with mosaic kariotypes, however they are associated with increased risk of poor outcome both for mother and fetus. We report a 4-day-old male infant delivered by women with mosaic TS who was admitted to the pediatric intensive care unit and presented with severe panhypopituitarism as the early manifestation of pituitary stalk interruption syndrome (PSIS). To the best of our knowledge this is the first report of severe panhypopituitarism in a newborn borne by women with TS.
authors.affiliation: Students Scientific Group, Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Olszewska
authors.affiliation: Students Scientific Group, Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Kiełbasa
authors.affiliation: Children's University Hospital, Krakow, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wójcik
authors.affiliation: Children's University Hospital, Krakow, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Zygmunt-Górska
authors.affiliation: Children's University Hospital, Krakow, Poland.
authors.forename: Jerzy B
authors.initials: JB
authors.lastname: Starzyk
mesh_terms: D050034:Antidiuretic Agents / Q000627:therapeutic use; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007018:Hypopituitarism / Q000175:diagnosis* / Q000188:drug therapy; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D010903:Pituitary Gland, Anterior / Q000002:abnormalities*; D011247:Pregnancy; D011248:Pregnancy Complications; D011994:Recombinant Proteins / Q000627:therapeutic use; D012688:Septum Pellucidum / Q000002:abnormalities*; D012720:Severity of Illness Index; D013974:Thyroxine / Q000627:therapeutic use; D014424:Turner Syndrome
chemical_list: D050034:Antidiuretic Agents; D011994:Recombinant Proteins; D019382:Human Growth Hormone; D003894:Deamino Arginine Vasopressin; D013974:Thyroxine; D006854:Hydrocortisone