title: Punigratane, a novel pyrrolidine alkaloid from Punica granatum rind with putative efflux inhibition activity.
abstract: A new pyrrolidine alkaloid named Punigratane was isolated from the rind of Punica granatum. This is the first report of a pyrrolidine-like structure from the rind. The activity of this compound was tested in a representative MDR Klebsiella pneumoniae strain which exhibited high efflux pump activity. At a concentration of 6 mg, this compound Punigratane was found to have efflux inhibition activity.
authors.affiliation: a Department of Biotechnology , Dr. M.G.R. Educational and Research Institute , Chennai , India.
authors.forename: Zumaana
authors.initials: Z
authors.lastname: Rafiq
authors.affiliation: a Department of Biotechnology , Dr. M.G.R. Educational and Research Institute , Chennai , India.
authors.forename: Sreevidya
authors.initials: S
authors.lastname: Narasimhan
authors.affiliation: b Institute of Surgical Gastroenterology and Liver Transplantation , Government Stanley Medical College and Hospital , Chennai , India.
authors.forename: Rosy
authors.initials: R
authors.lastname: Vennila
authors.affiliation: a Department of Biotechnology , Dr. M.G.R. Educational and Research Institute , Chennai , India.
authors.forename: Rama
authors.initials: R
authors.lastname: Vaidyanathan
keywords: Punigratane; Pyrrolidine alkaloid; RND efflux pump inhibitor; multidrug resistance; pomegranate rind