title: Diabetes and Kidney Disease: Role of Oxidative Stress.
abstract: Intrarenal oxidative stress plays a critical role in the initiation and progression of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of reactive oxygen species (ROS) in the context of concomitant, insufficient antioxidant pathways. Renal ROS production in diabetes is predominantly mediated by various NADPH oxidases (NOXs), but a defective antioxidant system as well as mitochondrial dysfunction may also contribute. Recent Advances: Effective agents targeting the source of ROS generation hold the promise to rescue the kidney from oxidative damage and prevent subsequent progression of DKD. Critical Issues and Future Directions: In the present review, we summarize and critically analyze molecular and cellular mechanisms that have been demonstrated to be involved in NOX-induced renal injury in diabetes, with particular focus on the role of increased glomerular injury, the development of albuminuria, and tubulointerstitial fibrosis, as well as mitochondrial dysfunction. Furthermore, novel agents targeting NOX isoforms are discussed. Antioxid. Redox Signal. 25, 657-684.
authors.affiliation: 1 Diabetic Complications Division, JDRF Danielle Alberti Memorial Centre for Diabetic Complications, Baker IDI Heart and Diabetes Institute , Melbourne, Australia .
authors.forename: Jay C
authors.initials: JC
authors.lastname: Jha
authors.affiliation: 1 Diabetic Complications Division, JDRF Danielle Alberti Memorial Centre for Diabetic Complications, Baker IDI Heart and Diabetes Institute , Melbourne, Australia .
authors.forename: Claudine
authors.initials: C
authors.lastname: Banal
authors.affiliation: 1 Diabetic Complications Division, JDRF Danielle Alberti Memorial Centre for Diabetic Complications, Baker IDI Heart and Diabetes Institute , Melbourne, Australia .
authors.forename: Bryna S M
authors.initials: BS
authors.lastname: Chow
authors.affiliation: 1 Diabetic Complications Division, JDRF Danielle Alberti Memorial Centre for Diabetic Complications, Baker IDI Heart and Diabetes Institute , Melbourne, Australia .|2 Department of Medicine, Monash University , Melbourne, Australia .
authors.forename: Mark E
authors.initials: ME
authors.lastname: Cooper
authors.affiliation: 1 Diabetic Complications Division, JDRF Danielle Alberti Memorial Centre for Diabetic Complications, Baker IDI Heart and Diabetes Institute , Melbourne, Australia .|2 Department of Medicine, Monash University , Melbourne, Australia .
authors.forename: Karin
authors.initials: K
authors.lastname: Jandeleit-Dahm
mesh_terms: D058186:Acute Kidney Injury / Q000235:genetics* / Q000473:pathology; D000975:Antioxidants / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D019255:NADPH Oxidases / Q000235:genetics; D018384:Oxidative Stress / Q000235:genetics*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D019255:NADPH Oxidases
keywords: NADPH-oxidases; albuminuria; diabetic nephropathy; reactive oxygen species