title: A single aldehyde group can serve as a structural element for recognition by transmembrane protein CD36.
abstract: Transmembrane protein CD36 is considered to bind its distinct ligands such as long-chain fatty acids primarily by recognizing their terminal carboxyl moiety. In this study, we provide evidence that long-chain fatty aldehydes, such as oleic aldehyde, can be recognized by CD36. We suggest that a single aldehyde group may also serve as one of the structural elements recognizable by CD36.
authors.affiliation: a Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture , Kyoto University , Kyoto , Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tsuzuki
authors.affiliation: b R&D Center , T. Hasegawa Co., Ltd. , Kawasaki , Japan.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Amitsuka
authors.affiliation: a Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture , Kyoto University , Kyoto , Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Okahashi
authors.affiliation: a Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture , Kyoto University , Kyoto , Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kozai
authors.affiliation: a Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture , Kyoto University , Kyoto , Japan.
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Matsumura
authors.affiliation: a Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture , Kyoto University , Kyoto , Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Inoue
authors.affiliation: c Faculty of Agriculture, Department of Food Science and Human Nutrition , Ryukoku University , Otsu , Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Fushiki
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001667:Binding, Competitive; D018955:CD36 Antigens / Q000037:antagonists & inhibitors / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000737:chemistry*; D010455:Peptides / Q000037:antagonists & inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D011485:Protein Binding; D013329:Structure-Activity Relationship
chemical_list: D000447:Aldehydes; D018955:CD36 Antigens; D005227:Fatty Acids; D008077:Lipoproteins, LDL; D010455:Peptides; C001634:fatty aldehyde; C099252:oxidized low density lipoprotein; C061128:11-hexadecenal; C547259:4-hydroperoxy-2-nonenal
keywords: CD36 ligands; aldehyde functional group; fatty acid-related molecules; oleic aldehyde; receptor-binding moiety