title: Genetic Variants of TPCN2 Associated with Type 2 Diabetes Risk in the Chinese Population.
abstract: OBJECTIVE
  The aim of this study was to determine whether TPCN2 genetic variants are associated with type 2 diabetes and to elucidate which variants in TPCN2 confer diabetes susceptibility in the Chinese population.
  
  
  METHODS
  The sample population included 384 patients with type 2 diabetes and 1468 controls. Anthropometric parameters, glycemic and lipid profiles and insulin resistance were measured. We selected 6 TPCN2 tag single nucleotide polymorphisms (rs35264875, rs267603153, rs267603154, rs3829241, rs1551305, and rs3750965). Genotypes were determined using a Sequenom MassARRAY SNP genotyping system.
  
  
  RESULTS
  Ultimately, we genotyped 3 single nucleotide polymorphisms (rs3750965, rs3829241, and rs1551305) in all individuals. There was a 5.1% higher prevalence of the rs1551305 variant allele in type 2 diabetes individuals (A) compared with wild-type homozygous individuals (G). The AA genotype of rs1551305 was associated with a higher diabetes risk (p<0.05). The distributions of rs3829241 and rs3750965 polymorphisms were not significantly different between the two groups. HOMA-%B of subjects harboring the AA genotype of rs1551305 decreased by 14.87% relative to the GG genotype.
  
  
  CONCLUSIONS
  TPCN2 plays a role in metabolic regulation, and the rs1551305 single nucleotide polymorphism is associated with type 2 diabetes risk. Future work will begin to unravel the underlying mechanisms.
authors.affiliation: Department of Endocrinology, Central Hospital of Minhang District, Minhang Hospital affiliated with Fudan University, Shanghai, People's Republic of China.
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Endocrinology, Central Hospital of Minhang District, Minhang Hospital affiliated with Fudan University, Shanghai, People's Republic of China.
authors.forename: Xuesong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Central Hospital of Minhang District, Minhang Hospital affiliated with Fudan University, Shanghai, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Central Hospital of Minhang District, Minhang Hospital affiliated with Fudan University, Shanghai, People's Republic of China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Endocrinology, Central Hospital of Minhang District, Minhang Hospital affiliated with Fudan University, Shanghai, People's Republic of China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Central Hospital of Minhang District, Minhang Hospital affiliated with Fudan University, Shanghai, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Endocrinology, Central Hospital of Minhang District, Minhang Hospital affiliated with Fudan University, Shanghai, People's Republic of China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Endocrinology, Central Hospital of Minhang District, Minhang Hospital affiliated with Fudan University, Shanghai, People's Republic of China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Shen
authors.affiliation: Department of Endocrinology, Central Hospital of Minhang District, Minhang Hospital affiliated with Fudan University, Shanghai, People's Republic of China.
authors.forename: Jiayi
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Endocrinology, Central Hospital of Minhang District, Minhang Hospital affiliated with Fudan University, Shanghai, People's Republic of China.
authors.forename: Fengdong
authors.initials: F
authors.lastname: Ren
authors.affiliation: Department of Endocrinology, Central Hospital of Minhang District, Minhang Hospital affiliated with Fudan University, Shanghai, People's Republic of China.
authors.forename: Jialin
authors.initials: J
authors.lastname: Yang
mesh_terms: D044466:Asian People / Q000235:genetics*; D015220:Calcium Channels / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D015220:Calcium Channels; C530224:TPCN2 protein, human