title: PSMA Expression in Papillary Thyroid Carcinoma: Opening a New Horizon in Management of Thyroid Cancer?
abstract: Prostate-specific membrane antigen (PSMA) is a type 2 transmembrane protein highly expressed in prostate cancer cells. We present the case of a 50-year-old man with metastatic papillary carcinoma of the thyroid, with rising thyroglobulin level and negative whole-body radioiodine scan after total thyroidectomy. Considering the limited treatment options available, it was decided to perform Ga-PSMA-HBED-CC PET/CT scan. It revealed intense radiotracer uptake in mediastinal and left supraclavicular lymph nodes, brain metastases, bilateral lung nodules, and skeletal sites. Patient also underwent F-FDG PET/CT. It demonstrated similar findings; however, the number of lesions detected in brain was less compared with Ga-PSMA PET/CT.
authors.affiliation: Form the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sameer Kamalakar
authors.initials: SK
authors.lastname: Taywade
authors.forename: Nishikant Avinash
authors.initials: NA
authors.lastname: Damle
authors.forename: Chandrasekhar
authors.initials: C
authors.lastname: Bal
mesh_terms: D000085:Acetates; D000954:Antigens, Surface / Q000378:metabolism*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D002291:Carcinoma, Papillary; D005029:Ethylenediamines; D019788:Fluorodeoxyglucose F18; D005710:Gallium Radioisotopes; D043425:Glutamate Carboxypeptidase II / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D000085:Acetates; D000954:Antigens, Surface; D005029:Ethylenediamines; D005710:Gallium Radioisotopes; C524457:N,N'-di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II