title: Biomechanical guidance helps elongate a lumen.
abstract: Transporting epithelia commonly consist of tubes that mediate between the body and its environment. Lumen formation is closely linked to epithelial morphogenesis, but an open question is how luminal symmetry is broken to generate tubes rather than hollow cysts. A report about the biomechanics of intercellular contacts might now provide some answers.
authors.affiliation: Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Wee
authors.affiliation: Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
authors.forename: Alpha S
authors.initials: AS
authors.lastname: Yap
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism*; D016023:Integrins / Q000378:metabolism*; D008297:Male; D038081:Organogenesis / Q000502:physiology*; D013314:Stress, Mechanical
chemical_list: D016023:Integrins