title: Context Specificity of Stress-activated Mitogen-activated Protein (MAP) Kinase Signaling: The Story as Told by Caenorhabditis elegans.
abstract: Stress-associated p38 and JNK mitogen-activated protein (MAP) kinase signaling cascades trigger specific cellular responses and are involved in multiple disease states. At the root of MAP kinase signaling complexity is the differential use of common components on a context-specific basis. The roundwormCaenorhabditis eleganswas developed as a system to study genes required for development and nervous system function. The powerful genetics ofC. elegansin combination with molecular and cellular dissections has led to a greater understanding of how p38 and JNK signaling affects many biological processes under normal and stress conditions. This review focuses on the studies revealing context specificity of different stress-activated MAPK components inC. elegans.
authors.affiliation: From the Howard Hughes Medical Institute and.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Andrusiak
authors.affiliation: From the Howard Hughes Medical Institute and the Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 yijin@ucsd.edu.
authors.forename: Yishi
authors.initials: Y
authors.lastname: Jin
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000276:immunology / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000276:immunology / Q000378:metabolism*; D007113:Immunity, Innate; D053612:Janus Kinases / Q000276:immunology / Q000378:metabolism; D020935:MAP Kinase Signaling System; D020928:Mitogen-Activated Protein Kinases / Q000276:immunology / Q000378:metabolism*; D013312:Stress, Physiological
chemical_list: D029742:Caenorhabditis elegans Proteins; D053612:Janus Kinases; D020928:Mitogen-Activated Protein Kinases
keywords: Janus kinase (JAK); axon; development; innate immunity; oxidative stress; p38 MAPK; regeneration; signal transduction; stress; synapse