title: Photo-protective activity of pogostone against UV-induced skin premature aging in mice.
abstract: Pogostone, a chemical constituent of patchouli oil, has been confirmed to possess favorable anti-inflammatory property. In the present study, we investigated the possible anti-photoaging potential of pogostone and the underlying mechanism against UV-induced skin damage in mice. The macroscopic and histopathological lesions were significantly ameliorated by pretreatment of pogostone as compared to the VC group. Furthermore, topical application of pogostone markedly increased the activities of the antioxidant enzymes, including catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and observably decreased malonaldehyde (MDA) level. Analysis of inflammatory cytokines showed obvious down-regulation of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β) and cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2) in the pogostone groups. In addition, pogostone pretreatment evidently inhibited the abnormal expression of matrix metalloproteinases (MMP-1 and MMP-3). Taken together, pogostone exhibited prominent photo-protective activity mainly by its antioxidative and anti-inflammatory properties, promising it as an effective alternative pharmaceutical therapy for photoaging.
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
authors.forename: Xiu-Fen
authors.initials: XF
authors.lastname: Wang
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Huang
authors.affiliation: The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China.
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
authors.forename: Lie-Qiang
authors.initials: LQ
authors.lastname: Xu
authors.affiliation: The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China.
authors.forename: Xiu-Ting
authors.initials: XT
authors.lastname: Yu
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Liu
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
authors.forename: Cai-Lan
authors.initials: CL
authors.lastname: Li
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
authors.forename: Janis Ya-Xian
authors.initials: JY
authors.lastname: Zhan
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
authors.forename: Zi-Ren
authors.initials: ZR
authors.lastname: Su
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. Electronic address: chenjiannan@gzucm.edu.cn.
authors.forename: Jian-Nan
authors.initials: JN
authors.lastname: Chen
authors.affiliation: The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China. Electronic address: gancaozhf@126.com.
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Zeng
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006965:Hyperplasia / Q000188:drug therapy; D008315:Malondialdehyde / Q000378:metabolism; D053509:Matrix Metalloproteinase 13 / Q000378:metabolism; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism; D051379:Mice; D009822:Oils, Volatile / Q000494:pharmacology / Q000627:therapeutic use*; D012867:Skin / Q000201:enzymology / Q000473:pathology*; D015595:Skin Aging / Q000187:drug effects*; D014466:Ultraviolet Rays
chemical_list: D000975:Antioxidants; D016207:Cytokines; D009822:Oils, Volatile; C483658:Pogostone; D008315:Malondialdehyde; D053509:Matrix Metalloproteinase 13; C507081:Mmp13 protein, mouse; D019278:Matrix Metalloproteinase 3; C511769:Mmp3 protein, mouse
keywords: Anti-inflammation; Antioxidant; Matrix metalloproteinases; Photoaging; Pogostone; Ultraviolet