title: Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome.
abstract: OBJECTIVE
  To examine potential correlations between maternal serum placental protein-13 (PP-13) and first trimester maternal and placental factors, and to evaluate the association of this marker with adverse pregnancy outcome.
  
  
  METHODS
  Serum samples from prospectively enrolled patients between 11 and 13 weeks and 6 days were analyzed for PP-13 using an ELISA assay. The relationships between maternal serum PP-13 levels and gestational age, maternal age, ethnicity, parity, smoking status, body mass index (BMI), mean arterial blood pressure, uterine and umbilical artery Doppler parameters were examined. The association between first-trimester PP-13 levels and subsequent pre-eclampsia and delivery of a small for gestational age (SGA) neonate was also investigated, after excluding patients who received aspirin.
  
  
  RESULTS
  In 908 patients, PP-13 levels ranged from 8.0 to 537.5 pg/mL. A significant negative correlation was identified between PP13 and BMI (Spearman rho -0.20, P<0.0001). Smoking significantly decreased PP-13 (P<0.01). No relationship was identified with the other parameters. In a subgroup of 668 low-risk patients who did not receive aspirin, PP-13 levels were not associated with development of pre-eclampsia, SGA or the combination of them.
  
  
  CONCLUSIONS
  First-trimester PP-13 levels are significantly correlated with BMI and smoking. These correlations appear independent of uterine and umbilical artery resistance. In low risk patients, PP-13 levels fail to predict the risk for pre-eclampsia or SGA.
authors.forename: Viola
authors.initials: V
authors.lastname: Seravalli
authors.forename: Yael Inna
authors.initials: YI
authors.lastname: Grimpel
authors.forename: Hamutal
authors.initials: H
authors.lastname: Meiri
authors.forename: Miriam
authors.initials: M
authors.lastname: Blitzer
authors.forename: Ahmet A
authors.initials: AA
authors.lastname: Baschat
mesh_terms: D015992:Body Mass Index; D005260:Female; D037161:Galectins / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D010920:Placenta / Q000098:blood supply / Q000000981:diagnostic imaging*; D011225:Pre-Eclampsia / Q000097:blood / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011257:Pregnancy Proteins / Q000097:blood*; D011261:Pregnancy Trimester, First / Q000097:blood*; D011446:Prospective Studies; D012307:Risk Factors; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D014599:Uterus / Q000098:blood supply; D014655:Vascular Resistance
chemical_list: D037161:Galectins; C038195:LGALS13 protein, human; D011257:Pregnancy Proteins