title: Functionalized Silica Nanoparticles As an Alternative Platform for Targeted Drug-Delivery of Water Insoluble Drugs.
abstract: The selective action of drugs in tumor cells is a major problem in cancer therapy. Most chemotherapy drugs act nonspecifically and damage both cancer and healthy cells causing various side effects. In this study, the preparation of a selective drug delivery system, which is able to act as a carrier for hydrophobic and anticancer drugs is reported. Amino-functionalized silica nanoparticles loaded with curcumin were successfully synthesized via sol-gel approach and duly characterized. Thereafter, the targeting ligand, folate, was covalently attached to amino groups of nanoparticle surface through amide bond formation. The cytotoxic effect of nanoparticles on prostate cancer cells line was evaluated and compared to normal cells line (prostate epithelial cell). Cytotoxicity experiments demonstrated that folate-functionalized nanoparticles were significantly cytotoxic to tumor cells, whereas normal cells were much less affected by the presence of these structures.
authors.affiliation: Laboratório Nacional de Luz Síncrotron (LNLS) , CEP 13083-970, Caixa Postal 6192, Campinas, São Paulo, Brazil.
authors.forename: Luciane França
authors.initials: LF
authors.lastname: de Oliveira
authors.affiliation: Laboratório Nacional de Luz Síncrotron (LNLS) , CEP 13083-970, Caixa Postal 6192, Campinas, São Paulo, Brazil.
authors.forename: Karim
authors.initials: K
authors.lastname: Bouchmella
authors.affiliation: Laboratório Nacional de Biociências (LNBio) , CEP 13083-970, Caixa Postal 6192, Campinas, São Paulo, Brazil.
authors.forename: Kaliandra de Almeida
authors.initials: Kde A
authors.lastname: Gonçalves
authors.affiliation: Laboratório Nacional de Nanotecnologia (LNNano) , CEP 13083-970, Caixa Postal 6192, Campinas, São Paulo Brazil.
authors.forename: Jefferson
authors.initials: J
authors.lastname: Bettini
authors.affiliation: Faculdade de Ciências Farmacêuticas e Departamento de Bioquímica e Biologia Tecidual - Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , CEP 13083-970, Caixa Postal 6154, Campinas, São Paulo Brazil.
authors.forename: Jörg
authors.initials: J
authors.lastname: Kobarg
authors.affiliation: Laboratório Nacional de Luz Síncrotron (LNLS) , CEP 13083-970, Caixa Postal 6192, Campinas, São Paulo, Brazil.
authors.forename: Mateus Borba
authors.initials: MB
authors.lastname: Cardoso
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D003474:Curcumin / Q000494:pharmacology* / Q000633:toxicity; D004121:Dimethyl Sulfoxide; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000633:toxicity; D005492:Folic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D010316:Particle Size; D011437:Propylamines / Q000737:chemistry / Q000633:toxicity; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011437:Propylamines; D012822:Silicon Dioxide; D005492:Folic Acid; D003474:Curcumin; D004121:Dimethyl Sulfoxide