title: Topiramate as a rare cause of reversible Fanconi syndrome and acute kidney injury: a case report and literature review.
abstract: Topiramate (TPM) is a sulfa-derivative monosaccharide that has been used for multiple indications in the last several years. We describe a 53-year-old woman with known chronic kidney disease stage 2 and baseline creatinine of 1 mg/dL who developed acute kidney injury and proximal renal tubular dysfunction while on TPM for depression. The Naranjo Adverse Drug Reaction Probability Scale indicated a probable relationship (score of 6) between TPM and acute kidney injury as well as proximal tubular dysfunction; these renal conditions resolved on withdrawal of TPM. To our knowledge, this is the first report of such a scenario. Patients receiving TPM therapy should be closely monitored for evidence of kidney dysfunction and electrolyte abnormalities.
authors.affiliation: Department of Internal Medicine, Guthrie Clinic, Sayre, PA, USA; marcellegeorge2000@hotmail.com.
authors.forename: Marcelle G
authors.initials: MG
authors.lastname: Meseeha
authors.affiliation: Department of Family Medicine, Guthrie Clinic, Sayre, PA, USA.
authors.forename: Maximos N
authors.initials: MN
authors.lastname: Attia
authors.affiliation: Department of Internal Medicine, Guthrie Clinic, Sayre, PA, USA.
authors.forename: Victor O
authors.initials: VO
authors.lastname: Kolade
keywords: acute kidney injury; drug-related side effects; proximal renal tubular dysfunction; topiramate