title: Retinal Tissue Thickness is Reduced in Diabetic Peripheral Neuropathy.
abstract: To investigate the relationship between diabetic peripheral neuropathy (DPN) and retinal tissue thickness.
  
  
  
  Full retinal thickness in the central retinal, parafoveal, and perifoveal zones and thickness of the ganglion cell complex and retinal nerve fiber layer (RNFL) were assessed in 193 individuals (84 with type 1 diabetes, 67 with type 2 diabetes, and 42 healthy controls) using spectral domain optical coherence tomography. Among those with diabetes, 44 had neuropathy defined using a modified neuropathy disability score recorded on a 0-10 scale. Multiple regression analysis was performed to investigate the relationship between diabetic neuropathy and retinal tissue thickness, adjusted for the presence of diabetic retinopathy (DR), age, sex, duration of diabetes, and HbA1clevels.
  
  
  
  In individuals with diabetes, perifoveal thickness was inversely related to the severity of neuropathy (p < 0.05), when adjusted for age, sex, duration of diabetes, and HbA1clevels. DR was associated with reduced thickness in parafovea (p < 0.01). The RNFL was thinner in individuals with greater degrees of neuropathy (p < 0.04).
  
  
  
  DPN is associated with structural compromise involving several retinal layers. This compromise may represent a threat to visual integrity and therefore warrants examination of functional correlates.
authors.affiliation: a Institute of Health and Biomedical Innovation , Queensland University of Technology , Queensland , Australia.
authors.forename: Sangeetha
authors.initials: S
authors.lastname: Srinivasan
authors.affiliation: a Institute of Health and Biomedical Innovation , Queensland University of Technology , Queensland , Australia.
authors.forename: Nicola
authors.initials: N
authors.lastname: Pritchard
authors.affiliation: a Institute of Health and Biomedical Innovation , Queensland University of Technology , Queensland , Australia.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Vagenas
authors.affiliation: a Institute of Health and Biomedical Innovation , Queensland University of Technology , Queensland , Australia.
authors.forename: Katie
authors.initials: K
authors.lastname: Edwards
authors.affiliation: a Institute of Health and Biomedical Innovation , Queensland University of Technology , Queensland , Australia.
authors.forename: Geoff P
authors.initials: GP
authors.lastname: Sampson
authors.affiliation: b Princess Alexandra Hospital , Queensland , Australia.|c School of Medicine , University of Queensland , Woolloongabba , Queensland , Australia.
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Russell
authors.affiliation: d Division of Cardiovascular Medicine , University of Manchester , Manchester , UK.|e Central Manchester Foundation Trust , Manchester , UK.
authors.forename: Rayaz A
authors.initials: RA
authors.lastname: Malik
authors.affiliation: a Institute of Health and Biomedical Innovation , Queensland University of Technology , Queensland , Australia.
authors.forename: Nathan
authors.initials: N
authors.lastname: Efron
mesh_terms: D000328:Adult; D000368:Aged; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003929:Diabetic Neuropathies / Q000175:diagnosis* / Q000209:etiology; D003930:Diabetic Retinopathy / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity
keywords: Diabetic peripheral neuropathy; ganglion cell complex; neuropathy disability score; retinal nerve fiber layer; retinal thickness