title: One-Pot Photochemical Ring-Opening/Cleavage Approach for the Synthesis and Decoding of Cyclic Peptide Libraries.
abstract: A novel dual ring-opening/cleavage strategy to determine the sequence of cyclic peptides from one bead, one compound libraries is described. The approach uses a photolabile residue within the macrocycle and as a linker to allow a simultaneous ring opening and cleavage from the beads upon UV irradiation and provide linearized molecules. Cyclic peptides of five to nine residues were synthesized and the generated linear peptides successfully sequenced by tandem mass spectrometry.
authors.affiliation: Faculty of Pharmacy, Université Laval , Québec, Québec G1V 0A6, Canada.|Laboratory of Medicinal Chemistry, Centre de recherche du Centre Hospitalier Universitaire de Québec , 2705 Boulevard Laurier, Québec, Québec G1V 4G2, Canada.
authors.forename: Xinxia
authors.initials: X
authors.lastname: Liang
authors.affiliation: Faculty of Pharmacy, Université Laval , Québec, Québec G1V 0A6, Canada.|Laboratory of Medicinal Chemistry, Centre de recherche du Centre Hospitalier Universitaire de Québec , 2705 Boulevard Laurier, Québec, Québec G1V 4G2, Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Vézina-Dawod
authors.forename: François
authors.initials: F
authors.lastname: Bédard
authors.affiliation: Faculty of Pharmacy, Université Laval , Québec, Québec G1V 0A6, Canada.|Laboratory of Medicinal Chemistry, Centre de recherche du Centre Hospitalier Universitaire de Québec , 2705 Boulevard Laurier, Québec, Québec G1V 4G2, Canada.
authors.forename: Karine
authors.initials: K
authors.lastname: Porte
authors.affiliation: Faculty of Pharmacy, Université Laval , Québec, Québec G1V 0A6, Canada.|Laboratory of Medicinal Chemistry, Centre de recherche du Centre Hospitalier Universitaire de Québec , 2705 Boulevard Laurier, Québec, Québec G1V 4G2, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Biron
mesh_terms: D015394:Molecular Structure; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D055668:Photochemical Processes; D053719:Tandem Mass Spectrometry
chemical_list: D019151:Peptide Library; D010455:Peptides; D010456:Peptides, Cyclic