title: Vitamin D supplementation in inflammatory bowel disease: the role of dosage and patient compliance.
abstract: OBJECTIVE
  Vitamin D substitution is recommended in patients with inflammatory bowel disease. Specific guidelines are lacking. The aim of this study was to assess the effect of vitamin D supplementation with respect to dosage and patient compliance.
  
  
  METHODS
  A prospective cohort study of 167 Crohn disease/ulcerative colitis outpatients. Patients were screened for serum vitamin D (25OHD2+3) at the end of summer and in late winter. Demographic data, history of vitamin D supplementation were recorded and matched with prescription records.
  
  
  RESULTS
  A total of 57 subjects used vitamin D supplementation (mean dose 1104 IU/day). 25OHD2+3 levels were lower (p < 0.001) in winter both in substituted and unsubstituted group, without any differences between groups within the same season. 25OHD2+3 levels did not correlate with the substitution dose. 52.1 % of subjects were fully compliant with substitution. 25OHD2+3 and prevalence of vitamin D deficit in this group were comparable with unsubstituted subjects except a higher prevalence of vitamin D insufficiency (p < 0.02).
  
  
  CONCLUSIONS
  Fixed dosage of 1100 IU/day of vitamin D was insufficient to correct the deficiency. Patient compliance with vitamin D supplementation was low, however this fact did not significantly contribute to the degree of vitamin D deficiency in this dosage (Tab. 3, Fig. 1, Ref. 21).
authors.forename: V
authors.initials: V
authors.lastname: Kojecky
authors.forename: A
authors.initials: A
authors.lastname: Adamikova
authors.forename: P
authors.initials: P
authors.lastname: Klimek
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003093:Colitis, Ulcerative; D003424:Crohn Disease; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D015995:Prevalence; D011446:Prospective Studies; D012621:Seasons; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D014815:Vitamins
chemical_list: D014815:Vitamins; D014807:Vitamin D
keywords: Crohn's disease.; inflammatory bowel disease; supplementation; vitamin D