title: New developments in osteoarthritis and cartilage biology.
abstract: Osteoarthritis (OA) is a degenerative joint disease and the most common form of arthritis. Characterised by articular cartilage loss, subchondral bone thickening and osteophyte formation, the OA joint afflicts much pain and disability. Whilst OA has been associated with many contributing factors, its underpinning molecular mechanisms are, nevertheless, not fully understood. Clinical management of OA is largely palliative and there is an ever growing need for an effective disease modifying treatment. This review discusses some of the recent progress in OA therapies in the different joint tissues affected by OA pathology.
authors.affiliation: Institute of Ageing and Chronic Disease, University of Liverpool, L7 8TX Liverpool, UK. Electronic address: b.poulet@liverpool.ac.uk.
authors.forename: Blandine
authors.initials: B
authors.lastname: Poulet
authors.affiliation: Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Staines
mesh_terms: D000818:Animals; D018501:Antirheumatic Agents / Q000494:pharmacology*; D002358:Cartilage, Articular / Q000187:drug effects* / Q000473:pathology; D015195:Drug Design; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy* / Q000473:pathology; D054850:Osteophyte / Q000378:metabolism; D010146:Pain / Q000188:drug therapy / Q000209:etiology
chemical_list: D018501:Antirheumatic Agents