title: Potential subchronic food safety of the stacked trait transgenic maize GH5112E-117C in Sprague-Dawley rats.
abstract: The food safety of stacked trait genetically modified (GM) maize GH5112E-117C containing insect-resistance gene Cry1Ah and glyphosate-resistant gene G2-aroA was evaluated in comparison to non-GM Hi-II maize fed to Sprague-Dawley rats during a 90-day subchronic feeding study. Three different dietary concentrations (12.5, 25 and 50 %, w/w) of the GM maize were used or its corresponding non-GM maize. No biologically significant differences in the animals' clinical signs, body weights, food consumption, hematology, clinical chemistry, organ weights and histopathology were found between the stacked trait GM maize groups, and the non-GM maize groups. The results of the 90-day subchronic feeding study demonstrated that the stacked trait GM maize GH5112E-117C is as safe as the conventional non-GM maize Hi-II.
authors.affiliation: College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Tsinghua Donglu, Beijing, 100083, China.
authors.forename: Shiwen
authors.initials: S
authors.lastname: Han
authors.affiliation: College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Tsinghua Donglu, Beijing, 100083, China.|The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing, 100083, China.
authors.forename: Shiying
authors.initials: S
authors.lastname: Zou
authors.affiliation: College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Tsinghua Donglu, Beijing, 100083, China.|The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing, 100083, China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: He
authors.affiliation: College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Tsinghua Donglu, Beijing, 100083, China.|The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing, 100083, China.
authors.forename: Kunlun
authors.initials: K
authors.lastname: Huang
authors.affiliation: College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Tsinghua Donglu, Beijing, 100083, China. mxh@cau.edu.cn.|The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing, 100083, China. mxh@cau.edu.cn.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Mei
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins / Q000235:genetics / Q000633:toxicity; D001774:Blood Chemical Analysis; D004731:Endotoxins / Q000235:genetics / Q000633:toxicity; D005260:Female; D059022:Food Safety; D006460:Hemolysin Proteins / Q000235:genetics / Q000633:toxicity; D008297:Male; D009929:Organ Size; D030821:Plants, Genetically Modified / Q000235:genetics*; D017207:Rats, Sprague-Dawley; D059550:Toxicity Tests, Subchronic; D015430:Weight Gain; D003313:Zea mays / Q000235:genetics*
chemical_list: D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins; D004731:Endotoxins; D006460:Hemolysin Proteins; C030956:insecticidal crystal protein, Bacillus Thuringiensis
keywords: Cry1Ah; G2-aroA; Genetically modified maize; Safety assessment