title: A Traditional Mouthwash (Punica granatum var pleniflora) for Controlling Gingivitis of Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial.
abstract: This study evaluates the safety and efficacy of Punica granatum var pleniflora mouthwash in treatment of diabetic gingivitis. In a double-blind randomized clinical trial 80 patients with diabetes mellitus and gingivitis were assigned to Golnaar and chlorhexidine 0.2% groups. After using mouthwashes for 2 weeks; participants underwent tooth scaling and the last visit was 2 weeks after scaling. The primary outcome measures were plaque, modified gingival and gingival bleeding indices, and pocket depth. Both interventions had significant improvement on all of the gingival and plaque indices (P < .001 for all indices). There were no significant differences between Golnaar and chlorhexidine in primary outcome measures except for modified gingival index for which Golnaar mouthwash had a superiority after 2 weeks when comparing with chlorhexidine (P = .039). Meanwhile, Golnaar mouthwash had no staining effect. Golnaar mouthwash is safe and effective in treatment of gingivitis in diabetic patients although further studies are recommended.
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Massih
authors.initials: M
authors.lastname: Sedigh-Rahimabadi
authors.affiliation: Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammadmehdi
authors.initials: M
authors.lastname: Fani
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.|Essence of Parsiyan Wisdom knowledge based Institute, Traditional Medicine and Medicinal Plant Incubator, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Rostami-Chijan
authors.affiliation: Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.|Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad M
authors.initials: MM
authors.lastname: Zarshenas
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran shams@sums.ac.ir.
authors.forename: Mesbah
authors.initials: M
authors.lastname: Shams
mesh_terms: D000328:Adult; D048909:Diabetes Complications / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005891:Gingivitis / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007492:Iran; D029561:Lythraceae; D008297:Male; D008514:Medicine, Arabic; D008875:Middle Aged; D009067:Mouthwashes / Q000009:adverse effects / Q000627:therapeutic use*; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D009067:Mouthwashes; D010936:Plant Extracts
keywords: Punica granatum var pleniflora; gingivitis; traditional Persian medicine