title: Demonstration of Brain Tumor-Induced Neurovascular Uncoupling in Resting-State fMRI at Ultrahigh Field.
abstract: To demonstrate in a small case series for the first time the phenomenon of brain tumor-related neurovascular uncoupling (NVU) in resting-state blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) at ultrahigh field (7T). Two de novo (i.e., untreated) brain tumor patients underwent both BOLD resting-state fMRI (rsfMRI) on a 7T MRI system and motor task-based BOLD fMRI at 3T. Ipsilesional (i.e., ipsilateral to tumor or IL) and contralesional (i.e., contralateral to tumor or CL) region of interest (ROI) analysis was performed on both 3T motor task-related general linear model-derived activation maps and on 7T rsfMRI independent component analysis (ICA)-derived sensorimotor network maps for each case. Asymmetry scores (ASs) were computed based on numbers of suprathreshold voxels in the IL and CL ROIs. In each patient, ASs derived from ROI analysis of suprathreshold voxels in IL and CL ROIs in task-related activation maps and rsfMRI ICA-derived sensorimotor component maps indicate greater number of suprathreshold voxels in contralesional than ipsilesional sensorimotor cortex in both maps. In patient 1, an AS of 0.2 was obtained from the suprathreshold Z-score spectrum (voxels with Z-scores >5.0) of the task-based activation map and AS of 1.0 was obtained from the suprathreshold Z-score spectrum (Z-scores >5.0) of the ICA-derived sensorimotor component map. Similarly, in patient 2, an AS of 1.0 was obtained from the suprathreshold Z-score spectrum (Z-scores >5.0) of the task-based activation map and an AS of 1.0 was obtained from the suprathreshold Z-score spectrum (Z-scores >5.0) of the ICA-derived sensorimotor component map. Overall, decreased BOLD signal was noted in IL compared with CL ROIs on both task-based activation maps and ultrahigh field resting-state maps, indicating the presence of NVU. We have demonstrated evidence of NVU on ultrahigh field 7T rsfMRI comparable with the findings on standard 3T motor task-based fMRI in both cases.
authors.affiliation: 1 Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Shruti
authors.initials: S
authors.lastname: Agarwal
authors.affiliation: 1 Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Haris I
authors.initials: HI
authors.lastname: Sair
authors.affiliation: 1 Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Raag
authors.initials: R
authors.lastname: Airan
authors.affiliation: 2 Division of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine , Baltimore, Maryland.|3 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute , Baltimore, Maryland.
authors.forename: Jun
authors.initials: J
authors.lastname: Hua
authors.affiliation: 2 Division of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine , Baltimore, Maryland.|3 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute , Baltimore, Maryland.
authors.forename: Craig K
authors.initials: CK
authors.lastname: Jones
authors.affiliation: 2 Division of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine , Baltimore, Maryland.|3 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute , Baltimore, Maryland.
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Heo
authors.affiliation: 4 Department of Neurosurgery, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Olivi
authors.affiliation: 5 Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health , Baltimore, Maryland.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Lindquist
authors.affiliation: 2 Division of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine , Baltimore, Maryland.|3 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute , Baltimore, Maryland.
authors.forename: James J
authors.initials: JJ
authors.lastname: Pekar
authors.affiliation: 1 Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Jay J
authors.initials: JJ
authors.lastname: Pillai
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology; D001931:Brain Mapping / Q000379:methods; D001932:Brain Neoplasms / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009043:Motor Activity / Q000502:physiology; D000069336:Neurovascular Coupling / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010865:Pilot Projects; D066191:Sensorimotor Cortex / Q000503:physiopathology
chemical_list: D010100:Oxygen
keywords: motor activation; neurovascular uncoupling; presurgical mapping; resting state fMRI; ultra-high field