title: PDK2 and ABCG2 genes polymorphisms are correlated with blood glucose levels and uric acid in Tibetan gout patients.
abstract: Previous studies have shown that the PDK2 and ABCG2 genes play important roles in many aspects of gout development in European populations. However, a detailed genotype-phenotype analysis was not performed. The aim of the present study was to investigate the potential association between variants in these two genes and metabolism-related quantitative phenotypes relevant to gout in a Chinese Tibetan population. In total, 316 Chinese Tibetan gout patients were recruited from rheumatology outpatient clinics and 6 single nucleotide polymorphisms in PDK2 and ABCG2 were genotyped, which were possible etiologic variants as identified in the HapMap Chinese Han Beijing population. A significant difference in blood glucose levels was detected between different genotypes of rs2728109 (P = 0.005) in the PDK2 gene. We also detected a significant difference in the mean serum uric levels between different genotypes of rs3114018 (P = 0.004) in the ABCG2 gene. All P values remained significant after Bonferroni's correction for multiple testing. Our data demonstrate potential roles for PDK2 and ABCG2 polymorphisms in the metabolic phenotypes of Tibetan gout patients, which may provide new insights into the etiology of gout. Further studies are required to confirm these findings.
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an, China.
authors.forename: Y C
authors.initials: YC
authors.lastname: Ren
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an, China.|Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.|Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
authors.forename: T B
authors.initials: TB
authors.lastname: Jin
authors.affiliation: Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: X D
authors.initials: XD
authors.lastname: Sun
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems, Xi'an, China.|First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
authors.forename: T T
authors.initials: TT
authors.lastname: Geng
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an, China.
authors.forename: M X
authors.initials: MX
authors.lastname: Zhang
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.|Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems, Xi'an, China.
authors.forename: T
authors.initials: T
authors.lastname: Feng
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.|Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
authors.forename: L L
authors.initials: LL
authors.lastname: Kang
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an, China.
authors.forename: C
authors.initials: C
authors.lastname: Chen
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000378:metabolism; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006073:Gout / Q000097:blood / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D060148:HapMap Project; D006801:Humans; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D000081382:Pyruvate Dehydrogenase Acetyl-Transferring Kinase; D017422:Sequence Analysis, DNA; D018609:Tibet; D014527:Uric Acid / Q000097:blood*
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D001786:Blood Glucose; D009363:Neoplasm Proteins; C000631430:PDK2 protein, human; D000081382:Pyruvate Dehydrogenase Acetyl-Transferring Kinase; D014527:Uric Acid; D017346:Protein Serine-Threonine Kinases