title: Bifunctional tertiary amine-squaramide catalyzed asymmetric catalytic 1,6-conjugate addition/aromatization of para-quinone methides with oxindoles.
abstract: The asymmetric catalytic 1,6-addition of p-QMs with racemic oxindoles under the bifunctional catalysis of C2-symmetric dimeric Cinchona-derived squaramide is described. This tertiary amine-squaramide catalyzed reaction provides a diastereoselective and enantioselective approach to the effective assembly of diverse diarylmethine-substituted oxindoles having vicinal tertiary and quaternary stereocenters.
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. fanchunan@lzu.edu.cn and University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Deng
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui Nanlu, Lanzhou 730000, China.
authors.forename: Xiang-Zhi
authors.initials: XZ
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui Nanlu, Lanzhou 730000, China.
authors.forename: Ke-Yin
authors.initials: KY
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui Nanlu, Lanzhou 730000, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui Nanlu, Lanzhou 730000, China.
authors.forename: Ji-Yuan
authors.initials: JY
authors.lastname: Du
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. fanchunan@lzu.edu.cn.
authors.forename: Hanmin
authors.initials: H
authors.lastname: Huang
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. fanchunan@lzu.edu.cn and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui Nanlu, Lanzhou 730000, China.
authors.forename: Chun-An
authors.initials: CA
authors.lastname: Fan
mesh_terms: D002384:Catalysis; D045563:Indolequinones / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D000078183:Oxindoles; D011803:Quinine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D045563:Indolequinones; D007211:Indoles; D000078183:Oxindoles; C000609819:squaramide; C022960:2-oxindole; C068040:quinone methide; D011803:Quinine