title: Our evolving science: studying the influence of sex in preclinical research.
abstract: The policy announcement by the National Institutes of Health that sex should be considered as a relevant variable in preclinical research has sparked considerable debate. This debate has largely centered on specific concerns regarding how the policy will be implemented. However, others have reacted to the new policy by calling into question the capacity of preclinical science to generate data that can be useful to human health. This commentary examines the basis for this contention and maintains that it is essential to expand our scientific efforts to include the influence of sex on the biology and behavior that is studied in preclinical investigations.
authors.affiliation: Department of Psychiatry, Women's Health Research at Yale, Yale University School of Medicine, 135 College Street, Suite 220, New Haven, CT 06510 USA.
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Mazure
keywords: Laboratory research; Preclinical research; Sex differences