title: Clinical Genomics: From Pathogenicity Claims to Quantitative Risk Estimates.
authors.affiliation: Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts.
authors.forename: Arjun K
authors.initials: AK
authors.lastname: Manrai
authors.affiliation: Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, California3Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California.
authors.forename: John P A
authors.initials: JP
authors.lastname: Ioannidis
authors.affiliation: Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts.
authors.forename: Isaac S
authors.initials: IS
authors.lastname: Kohane
mesh_terms: D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000592:standards*; D014644:Genetic Variation; D023281:Genomics / Q000592:standards*; D006432:Hemochromatosis / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D033181:Information Dissemination; D007753:Laboratories / Q000592:standards; D019683:Penetrance; D057285:Precision Medicine / Q000592:standards*; D018570:Risk Assessment / Q000592:standards; D015983:Selection Bias; D035501:Uncertainty