title: When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH.
authors.affiliation: Duke University School of Medicine, Durham, NC, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Levy
authors.affiliation: University of Insubria, Varese, Italy.
authors.forename: W
authors.initials: W
authors.lastname: Ageno
authors.affiliation: Monash University, Clayton, Vic., Australia.
authors.forename: N C
authors.initials: NC
authors.lastname: Chan
authors.affiliation: McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Crowther
authors.affiliation: University of Leuven, Leuven, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Verhamme
authors.affiliation: McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada.
authors.forename: J I
authors.initials: JI
authors.lastname: Weitz
mesh_terms: D000284:Administration, Oral; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D000931:Antidotes / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001120:Arginine / Q000031:analogs & derivatives / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects*; D003029:Coagulants / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015951:Factor Xa / Q000627:therapeutic use; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D010879:Piperazines / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000925:Anticoagulants; D000931:Antidotes; D003029:Coagulants; C580915:PRT064445; D010879:Piperazines; D011994:Recombinant Proteins; D001120:Arginine; C000594745:idarucizumab; D015951:Factor Xa; C000593571:PER977