title: Sex Differences in Risk Factors and Natural History of Oral Human Papillomavirus Infection.
abstract: Oral human papillomavirus genotype 16 (HPV16) infection causes oropharyngeal squamous cell carcinoma (SCC), and the prevalence of oropharyngeal SCC is higher among men than women in the United States. In a cohort study of oral HPV infection among 409 individuals aged 18-25 years, the risk among men but not among women significantly increased as the number of recent (ie, within the prior 3 months) oral sex partners increased (Pinteraction = .05). In contrast, the risk among women but not among men significantly decreased as the lifetime number of vaginal sex partners increased (Pinteraction = .037). Men were also significantly less likely than women to clear oral HPV infection. Our data contribute to understanding sex differences in risk for HPV-positive oropharyngeal SCC.
  
  
  
  NCT00994019.
authors.affiliation: Johns Hopkins Bloomberg School of Public Health.
authors.forename: Gypsyamber
authors.initials: G
authors.lastname: D'Souza
authors.affiliation: Johns Hopkins Bloomberg School of Public Health.
authors.forename: Alicia
authors.initials: A
authors.lastname: Wentz
authors.affiliation: Johns Hopkins Bloomberg School of Public Health.
authors.forename: Nicole
authors.initials: N
authors.lastname: Kluz
authors.affiliation: Johns Hopkins Bloomberg School of Public Health.
authors.forename: Yuehan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Johns Hopkins Bloomberg School of Public Health.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sugar
authors.affiliation: Baltimore County Health Department, Maryland.
authors.forename: Renee M
authors.initials: RM
authors.lastname: Youngfellow
authors.affiliation: Ohio State University Comprehensive Cancer Center, Columbus.
authors.forename: Yingshi
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Ohio State University Comprehensive Cancer Center, Columbus.
authors.forename: Weihong
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Ohio State University Comprehensive Cancer Center, Columbus.
authors.forename: Maura L
authors.initials: ML
authors.lastname: Gillison
mesh_terms: D000293:Adolescent; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000821:virology; D015331:Cohort Studies; D005260:Female; D052162:Human papillomavirus 16 / Q000235:genetics*; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000453:epidemiology* / Q000821:virology; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology* / Q000821:virology; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D012725:Sexual Behavior / Q000706:statistics & numerical data; D012747:Sexual Partners; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: STD clinic; epidemiology; oral HPV; sex; young adults