title: Comparison of idiopathic (isolated) aortitis and giant cell arteritis-related aortitis. A French retrospective multicenter study of 117 patients.
abstract: OBJECTIVE
  The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis.
  
  
  METHODS
  Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall thickening >2mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared.
  
  
  RESULTS
  Among 191 patients with non-infectious aortitis, 73 with GCA and 44 with IA were included. Patients with IA were younger (65 vs 70 years, p=0.003) and comprised more past/current smokers (43 vs 15%, p=0.0007). Aortic aneurisms were more frequent (38% vs 20%, p=0.03), and aortic wall thickening was more pronounced in IA. During follow-up (median=34 months), subsequent development of aortic aneurysm was significantly lower in GCA when compared to IA (p=0.009). GCA patients required significantly less aortic surgery during follow-up than IA patients (p=0.02). Mean age, sex ratio, inflammatory parameters, and free of aortic aneurism survival were equivalent in patients with IA ≥ 60 years when compared to patients with GCA-related aortitis.
  
  
  CONCLUSIONS
  IA is more severe than aortitis related to GCA, with higher proportions of aortic aneurism at diagnosis and during follow-up. IA is a heterogeneous disease and its prognosis is worse in younger patients <60 years. Most patients with IA ≥ 60 years share many features with GCA-related aortitis.
authors.affiliation: Department of Diagnostic Cardio-vascular Imaging, University hospital of Nantes, Nantes, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Espitia
authors.affiliation: Department of Internal Medicine and Clinical Immunology, University Hospital of Dijon, Dijon, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Samson
authors.affiliation: Department of Internal Medicine, University Hospital of Rennes, Rennes, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Le Gallou
authors.affiliation: Department of Diagnostic Cardio-vascular Imaging, University hospital of Nantes, Nantes, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Connault
authors.affiliation: Department of Internal Medicine, University Hospital of Poitiers, Poitiers, France.
authors.forename: Cedric
authors.initials: C
authors.lastname: Landron
authors.affiliation: Department of Internal Medicine, University Hospital of Angers, Angers, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Lavigne
authors.affiliation: Department of Internal Medicine, University Hospital of Angers, Angers, France.
authors.forename: Cristina
authors.initials: C
authors.lastname: Belizna
authors.affiliation: Department of Internal Medicine, CHRU of Tours, Tours, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Magnant
authors.affiliation: Department of Internal Medicine, University Hospital of Brest, Brest, France.
authors.forename: Claire
authors.initials: C
authors.lastname: de Moreuil
authors.affiliation: Department of Internal Medicine, University Hospital of Poitiers, Poitiers, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Roblot
authors.affiliation: Department of Internal Medicine, CHRU of Tours, Tours, France.
authors.forename: François
authors.initials: F
authors.lastname: Maillot
authors.affiliation: Department of Internal Medicine, CHRU of Tours, Tours, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Diot
authors.affiliation: Department of Internal Medicine, University Hospital of Rennes, Rennes, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Jégo
authors.affiliation: Department of Diagnostic Cardio-vascular Imaging, University hospital of Nantes, Nantes, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Durant
authors.affiliation: Department of Diagnostic Cardio-vascular Imaging, University hospital of Nantes, Nantes, France.
authors.forename: A
authors.initials: A
authors.lastname: Masseau
authors.affiliation: Department of Diagnostic Cardio-vascular Imaging, University hospital of Nantes, Nantes, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Brisseau
authors.affiliation: Department of Diagnostic Cardio-vascular Imaging, University hospital of Nantes, Nantes, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Pottier
authors.affiliation: Department of Diagnostic Cardio-vascular Imaging, University hospital of Nantes, Nantes, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Espitia-Thibault
authors.affiliation: Department of Hematology, Hospital of Vannes, Vannes, France.
authors.forename: Anabele Dos
authors.initials: AD
authors.lastname: Santos
authors.affiliation: Department of Diagnostic Cardio-vascular Imaging, University hospital of Nantes, Nantes, France.
authors.forename: François
authors.initials: F
authors.lastname: Perrin
authors.affiliation: Department of Diagnostic Cardio-vascular Imaging, University hospital of Nantes, Nantes, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Artifoni
authors.affiliation: Department of Diagnostic Cardio-vascular Imaging, University hospital of Nantes, Nantes, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Néel
authors.affiliation: Department of Medicine, Hospital of Saint-Nazaire, Saint-Nazaire, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Graveleau
authors.affiliation: Department of Hematology, Hospital of Lorient, Lorient, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Moreau
authors.affiliation: Department of Hematology, Hospital of La Roche sur Yon, La Roche sur Yon, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Maisonneuve
authors.affiliation: Department of Radiology, University Hospital of Nantes, Nantes, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Fau
authors.affiliation: Department of Radiology, University Hospital of Nantes, Nantes, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Serfaty
authors.affiliation: Department of Diagnostic Cardio-vascular Imaging, University hospital of Nantes, Nantes, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hamidou
authors.affiliation: Department of Diagnostic Cardio-vascular Imaging, University hospital of Nantes, Nantes, France. Electronic address: christian.agard@chu-nantes.fr.
authors.forename: Christian
authors.initials: C
authors.lastname: Agard
mesh_terms: D000368:Aged; D001014:Aortic Aneurysm / Q000175:diagnosis* / Q000473:pathology; D001025:Aortitis / Q000175:diagnosis* / Q000473:pathology; D005602:France; D013700:Giant Cell Arteritis / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D011379:Prognosis; D012189:Retrospective Studies
keywords: Aortic aneurysm; Aortitis; Giant cell arteritis; Idiopathic aortitis; Isolated aortitis