title: Effects of roux-en-Y gastric bypass surgery on postprandial fructose metabolism.
abstract: OBJECTIVE
  Fructose is partly metabolized in small bowel enterocytes, where it can be converted into glucose or fatty acids. It was therefore hypothesized that Roux-en-Y gastric bypass (RYGB) may significantly alter fructose metabolism.
  
  
  METHODS
  We performed a randomized clinical study in eight patients 12-17 months after RYGB and eight control (Ctrl) subjects. Each participant was studied after ingestion of a protein and lipid meal (PL) and after ingestion of a protein+lipid+fructose+glucose meal labeled with (13) C-fructose (PLFG). Postprandial blood glucose, fructose, lactate, apolipoprotein B48 (apoB48), and triglyceride (TG) concentrations, (13) C-palmitate concentrations in chylomicron-TG and VLDL-TG, fructose oxidation ((13) CO2 production), and gluconeogenesis from fructose (GNGf) were measured over 6 hours.
  
  
  RESULTS
  After ingestion of PLFG, postprandial plasma fructose, glucose, insulin, and lactate concentrations increased earlier and reached higher peak values in RYGB than in Ctrl. GNGf was 33% lower in RYGB than Ctrl (P = 0.041), while fructose oxidation was unchanged. Postprandial incremental areas under the curves for total TG and chylomicrons-TG were 72% and 91% lower in RYGB than Ctrl (P = 0.064 and P = 0.024, respectively). ApoB48 and (13) C-palmitate concentrations were not significantly different.
  
  
  CONCLUSIONS
  Postprandial fructose metabolism was not grossly altered, but postprandial lipid concentrations were markedly decreased in subjects having had RYGB surgery.
authors.affiliation: Department of Physiology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Anna
authors.initials: A
authors.lastname: Surowska
authors.affiliation: Department of Physiology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Sara
authors.initials: S
authors.lastname: De Giorgi
authors.affiliation: Department of Physiology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Fanny
authors.initials: F
authors.lastname: Theytaz
authors.affiliation: Department of Physiology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Campos
authors.affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
authors.forename: Leanne
authors.initials: L
authors.lastname: Hodson
authors.affiliation: Department of Physiology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Stefanoni
authors.affiliation: Department of Physiology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Valentine
authors.initials: V
authors.lastname: Rey
authors.affiliation: Department of Physiology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Philippe
authors.initials: P
authors.lastname: Schneiter
authors.affiliation: Centre De Recherche En Nutrition Humaine Rhône Alpes, Centre Européen De Nutrition Pour La Santé, Hospices Civils De Lyon, Université Lyon 1, Pierre Bénite, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Laville
authors.affiliation: Service of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Giusti
authors.affiliation: Centre De Recherche En Nutrition Humaine Rhône Alpes, Centre Européen De Nutrition Pour La Santé, Hospices Civils De Lyon, Université Lyon 1, Pierre Bénite, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Gabert
authors.affiliation: Department of Physiology, University of Lausanne, Lausanne, Switzerland.|Service of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Luc
authors.initials: L
authors.lastname: Tappy
mesh_terms: D000328:Adult; D000368:Aged; D000713:Anastomosis, Roux-en-Y; D053283:Apolipoprotein B-48 / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D005260:Female; D005632:Fructose / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007328:Insulin / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000187:drug effects*; D014280:Triglycerides / Q000097:blood
chemical_list: D053283:Apolipoprotein B-48; D001786:Blood Glucose; D007328:Insulin; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride; D005632:Fructose