title: Vobatensines A-F, Cytotoxic Iboga-Vobasine Bisindoles from Tabernaemontana corymbosa.
abstract: Six new bisindole alkaloids of the iboga-vobasine type, vobatensines A-F (1-6), in addition to four known bisindoles (8-11), were isolated from a stem bark extract of a Malayan Tabernaemontana corymbosa. The structures of these alkaloids were determined based on analysis of the spectroscopic data and in the case of vobatensines A (1), B (2), and 16'-decarbomethoxyvoacamine (8) also confirmed by partial syntheses. Nine of these alkaloids (1-5, 8-11) showed pronounced in vitro growth inhibitory activity against human KB, PC-3, LNCaP, HCT 116, HT-29, MCF7, MDA-MB-231, and A549 cancer cells.
authors.affiliation: Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia.
authors.forename: Dawn Su-Yin
authors.initials: DS
authors.lastname: Sim
authors.affiliation: Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia.
authors.forename: Wuen-Yew
authors.initials: WY
authors.lastname: Teoh
authors.affiliation: Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia.
authors.forename: Kae-Shin
authors.initials: KS
authors.lastname: Sim
authors.affiliation: Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia.
authors.forename: Siew-Huah
authors.initials: SH
authors.lastname: Lim
authors.affiliation: Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia.
authors.forename: Noel F
authors.initials: NF
authors.lastname: Thomas
authors.affiliation: Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia.
authors.forename: Yun-Yee
authors.initials: YY
authors.lastname: Low
authors.affiliation: Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia.
authors.forename: Toh-Seok
authors.initials: TS
authors.lastname: Kam
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007624:KB Cells; D008296:Malaysia; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D030014:Tabernaemontana / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; C057239:vobasine