title: Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis.
abstract: Advances in the field of cancer immunology, including studies on tumor-infiltrating CD8+ cytotoxic T lymphocytes (CTLs), have led to new immunotherapeutics with proven efficacy against late-stage cancers. However, the antitumor potential of the immune system in targeting early-stage cancers remains uncertain. Here, we demonstrated that both genetic and chemical induction of thymic stromal lymphopoietin (TSLP) at a distant site leads to robust antitumor immunity against spontaneous breast carcinogenesis in mice. Breast tumors exposed to high circulating levels of TSLP were arrested at an early adenoma-like stage and were prevented from advancing to late carcinoma and metastasis. Additionally, CD4+ Th2 cells mediated the antitumor effects of TSLP, challenging the notion that Th2 cells only promote cancer. We also discovered that TSLP is expressed by the breast tumor cells themselves and acts to block breast cancer promotion. Moreover, TSLP-induced immunity also blocked early stages of pancreatic cancer development. Together, our findings demonstrate that TSLP potently induces immunity directed against early stages of breast cancer development without causing inflammation in the normal breast tissue. Moreover, our results highlight a previously unappreciated function of the immune system in controlling the early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunity against early-stage cancers.
authors.forename: Shadmehr
authors.initials: S
authors.lastname: Demehri
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Cunningham
authors.forename: Sindhu
authors.initials: S
authors.lastname: Manivasagam
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Ngo
authors.forename: Sara
authors.initials: S
authors.lastname: Moradi Tuchayi
authors.forename: Rasika
authors.initials: R
authors.lastname: Reddy
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Meyers
authors.forename: David G
authors.initials: DG
authors.lastname: DeNardo
authors.forename: Wayne M
authors.initials: WM
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D016207:Cytokines / Q000235:genetics / Q000276:immunology*; D005260:Female; D007111:Immunity, Cellular; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D018418:Th2 Cells / Q000276:immunology* / Q000473:pathology; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000276:immunology*; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D025521:Tumor Suppressor Proteins; D000094632:Thymic Stromal Lymphopoietin; C000721967:TSLP protein, mouse