title: The pharmacogenomics of pain management: prospects for personalized medicine.
abstract: Pain is a common symptom that can be complex to treat. Analgesic medications are the mainstay treatment, but there is wide interindividual variability in analgesic response and adverse effects. Pharmacogenomics is the study of inherited genetic traits that result in these individual responses to drugs. This narrative review will attempt to cover the current understanding of the pharmacogenomics of pain, examining common genes affecting metabolism of analgesic medications, their distribution throughout the body, and end organ effects.
authors.affiliation: Department of Anaesthesia, Sir Charles Gairdner Hospital, Perth, WA, Australia.
authors.forename: Sonya
authors.initials: S
authors.lastname: Ting
authors.affiliation: Anaesthesiology Unit, School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia; Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, University of Western Australia Anaesthesiology Unit, Royal Perth Hospital, Perth, WA, Australia.
authors.forename: Stephan
authors.initials: S
authors.lastname: Schug
keywords: COMT; cytochrome P450; inherited traits; pharmacodynamics; pharmacokinetics