title: Efficacy of Analgesic Treatments to Manage Children's Postoperative Pain After Laparoscopic Appendectomy: Retrospective Medical Record Review.
abstract: Knowledge of the effectiveness of multimodal analgesic treatments to manage children's postoperative pain during hospital stays is limited. Our retrospective chart review of a convenience sample of 200 pediatric surgical patients' pain experiences during the first 24 hours after laparoscopic appendectomy demonstrates the benefits of a multimodal analgesic approach. We found that pediatric patients who received perioperative IV ketorolac in addition to opioids reported statistically significantly lower mean pain intensity (n = 134, mean [M] = 2.9, standard deviation [SD] = 1.7) during the first 24 hours after surgery when compared with the pain intensity of patients who did not receive perioperative IV ketorolac (n = 66, M = 3.7, SD = 1.7, t = 3.14, P = .002). Patients who received perioperative IV ketorolac (M = 0.94, SD = 0.71) also received significantly fewer morphine equivalents of postoperative opioids during the first 24 hours after surgery than those who did not (M = 1.21, SD = 0.78, t = 2.41, P = .02). We will use data from these patients to introduce the potential for a personalized medicine approach to postoperative pain.
authors.forename: Renee C B
authors.initials: RC
authors.lastname: Manworren
authors.forename: Connor D
authors.initials: CD
authors.lastname: McElligott
authors.forename: Peter V
authors.initials: PV
authors.lastname: Deraska
authors.forename: James
authors.initials: J
authors.lastname: Santanelli
authors.forename: Sherry
authors.initials: S
authors.lastname: Blair
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Ruscher
authors.forename: Richard
authors.initials: R
authors.lastname: Weiss
authors.forename: Christine
authors.initials: C
authors.lastname: Rader
authors.forename: Christine
authors.initials: C
authors.lastname: Finck
authors.forename: Michael
authors.initials: M
authors.lastname: Bourque
authors.forename: Brendan
authors.initials: B
authors.lastname: Campbell
mesh_terms: D000293:Adolescent; D000700:Analgesics / Q000627:therapeutic use*; D001062:Appendectomy / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008485:Medical Audit; D010149:Postoperative Pain / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D000700:Analgesics
keywords: IV ketorolac; laparoscopic appendectomy; pediatric analgesia; pediatric pain; postoperative pain management