title: Diagnostic Value of microRNA for Alzheimer's Disease: A Systematic Review and Meta-Analysis.
abstract: Sound evidence indicates that microRNAs (miRNAs) are aberrantly expressed in Alzheimer's disease (AD) patients. We performed a systematic review and meta-analysis to investigate the role of miRNA in AD pathogenesis and their clinical diagnostic value; a systematic review of literature and meta-analysis of clinical trials were performed. In the systematic review, 236 papers were included, and we reviewed the dysregulated miRNA expression in different parts of AD patients in order to identify the relationship between aberrantly expressed miRNAs and AD pathology. In the subsequent meta-analysis, seven studies were statistically analyzed with the following results: pooled sensitivity 0.86 (95%CI 0.79-0.90), pooled specificity 0.87 (95%CI 0.72-0.95), diagnostic odds ratio (28.29), and the area under the curve (0.87). In conclusion, our review indicated that aberrant expression of various miRNAs plays an important role in the pathological process of AD, and statistical analysis of quantitative studies reveal the potential value of specific miRNAs in the diagnosis of AD.
authors.affiliation: Department of Neurology, Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Yong-Bo
authors.initials: YB
authors.lastname: Hu
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Chun-Bo
authors.initials: CB
authors.lastname: Li
authors.affiliation: St George Hospital , Sydney, NSW , Australia.
authors.forename: Ning
authors.initials: N
authors.lastname: Song
authors.affiliation: Department of Neurology, Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Department of Neurology, Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Sheng-Di
authors.initials: SD
authors.lastname: Chen
authors.affiliation: Department of Neurology, Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Ru-Jing
authors.initials: RJ
authors.lastname: Ren
authors.affiliation: Department of Neurology, Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
keywords: Alzheimer’s disease; diagnostic value; meta-analysis; miRNA; systematic review