title: Comprehensive monitoring of cardiac remodeling with aortic stroke volume values provided by a phase-contrast MRI sequence.
abstract: OBJECTIVE
  Blood pressure (BP) and its changes with antihypertensive therapy are key parameters when monitoring left ventricular (LV) remodeling. This dual cross-sectional and longitudinal MRI study aimed to determine whether this monitoring is enhanced by aortic stroke volume (SV) values provided by a phase-contrast sequence.
  
  
  METHODS
  The study involved 334 MRI examinations from 247 study participants who had no significant cardiac disease (18-85 years old, 40% with hypertension) and among whom 48 had a 2-4-year MRI follow-up. Left ventricular hypertrophy and concentric geometry were: respectively assessed according to LV mass indexed to body surface area (g/m) and mass/end-diastolic volume ratio (concentric remodeling index); and correlated with vascular parameters involving BP and the indexed SV (ml/m) determined in the ascending aorta with a phase-contrast sequence.
  
  
  RESULTS
  Stroke volume was highly variable, ranging from 22 to 74 ml/m. The best cross-sectional correlates were: mean BP × SV product, reflecting cardiac work, for LV mass (r = 0.21); and mean BP/SV ratio, reflecting arterial load, for concentric geometry (r = 0.29). These two SV-derived parameters led to more than two-fold enhancements in cross-sectional predictions compared with BP parameters alone, whereas their longitudinal changes over time paralleled those of concentric geometry (P = 0.003 for mean BP/SV) and LV mass (P = 0.006 for mean BP × SV), suggesting direct links with cardiac remodeling.
  
  
  CONCLUSIONS
  The determination of aortic SV with a phase-contrast sequence leads to a significant enhancement in the characterization and monitoring of cardiac remodeling.
authors.affiliation: aCHU-Nancy, Nuclear Medecine and Nancyclotep Platform bINSERM, UMR-1116 cUniversité de Lorraine, Faculté de Medecine dINSERM, UMR-947 eCHU-Nancy, Department of Radiology fCHU-Nancy, Department of Cardiology gINSERM CIC-1433 hCHU-Nancy, Department of Geriatrics, Nancy, France.
authors.forename: Pierre Y
authors.initials: PY
authors.lastname: Marie
authors.forename: Damien
authors.initials: D
authors.lastname: Mandry
authors.forename: Olivier
authors.initials: O
authors.lastname: Huttin
authors.forename: Emilien
authors.initials: E
authors.lastname: Micard
authors.forename: Laurent
authors.initials: L
authors.lastname: Bonnemains
authors.forename: Nicolas
authors.initials: N
authors.lastname: Girerd
authors.forename: Marine
authors.initials: M
authors.lastname: Beaumont
authors.forename: Renaud
authors.initials: R
authors.lastname: Fay
authors.forename: Laure
authors.initials: L
authors.lastname: Joly
authors.forename: Patrick
authors.initials: P
authors.lastname: Rossignol
authors.forename: Athanase
authors.initials: A
authors.lastname: Benetos
authors.forename: Jacques
authors.initials: J
authors.lastname: Felblinger
authors.forename: Faïez
authors.initials: F
authors.lastname: Zannad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume / Q000502:physiology*; D020257:Ventricular Remodeling / Q000502:physiology*; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents