title: Postprandial GLP-1 Secretion After Bariatric Surgery in Three Cases of Severe Obesity Related to Craniopharyngiomas.
abstract: Craniopharyngiomas are rare cerebral tumors associated with severe obesity after hypothalamic surgery. A meta-analysis showed significant weight loss at 1 year after bariatric surgery in these patients even though more modest than in common causes of obesity. We hypothesized that this discrepancy could be partly explained by differences in GLP-1 secretion after surgery since patients with craniopharyngioma present a significantly higher degree of insulin resistance and hyperinsulinism than common obese control. We report three cases of bariatric surgery in patients presenting with hypothalamique obesity related to craniopharyngiomas. At 18 months, the mean weight loss was 20 kg with expected insulin resistance decrease. Before surgery, standardized test meal shows abolition of postprandial GLP-1 secretion in all patients with a progressive restoration in the patients with gastric bypass (GBP) surgery.
authors.affiliation: Department of Nutrition, Ambroise Paré Hospital, AP-HP, Université de Versailles Saint-Quentin en Yvelines, Boulogne-Billancourt, 92100, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Bretault
authors.affiliation: Department of Nutrition, Ambroise Paré Hospital, AP-HP, Université de Versailles Saint-Quentin en Yvelines, Boulogne-Billancourt, 92100, France.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Laroche
authors.affiliation: Department of Oncology and Endocrine Biochemistry, Pitié-Salpétrière Hospital, AP-HP, Paris, France.|Sorbonne Universités, UPMC Univ Paris 06F-75005, Paris, France.|INSERM, UMR_S 1166, Institute of Cardio-Metabolism and Nutrition (ICAN), Paris, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Lacorte
authors.affiliation: Department of Nutrition, Ambroise Paré Hospital, AP-HP, Université de Versailles Saint-Quentin en Yvelines, Boulogne-Billancourt, 92100, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Barsamian
authors.affiliation: Pediatric Endocrine Unit, Necker Enfants-Malades Hospital, AP-HP, Université Paris-Descartes, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Polak
authors.affiliation: Department of Endocrinology, Ambroise Paré Hospital, AP-HP, Université de Versailles Saint-Quentin en Yvelines, Boulogne-Billancourt, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Raffin-Sanson
authors.affiliation: Endocrine and Reproductive Medicine Division, Pitié-Salpétrière Hospital, AP-HP, Université Pierre et Marie Curie, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Touraine
authors.affiliation: Department of Metabolic Surgery, Ambroise Paré Hospital, AP-HP, Université de Versailles Saint-Quentin en Yvelines, Boulogne-Billancourt, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Bouillot
authors.affiliation: Department of Nutrition, Ambroise Paré Hospital, AP-HP, Université de Versailles Saint-Quentin en Yvelines, Boulogne-Billancourt, 92100, France.|INSERM, U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Czernichow
authors.affiliation: Department of Nutrition, Ambroise Paré Hospital, AP-HP, Université de Versailles Saint-Quentin en Yvelines, Boulogne-Billancourt, 92100, France. claire.carette@aphp.fr.
authors.forename: Claire
authors.initials: C
authors.lastname: Carette
mesh_terms: D050110:Bariatric Surgery; D003397:Craniopharyngioma / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000209:etiology / Q000378:metabolism* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D019518:Postprandial Period; D055815:Young Adult
chemical_list: D052216:Glucagon-Like Peptide 1
keywords: Bariatric surgery; Craniopharyngioma; GLP-1; Gastric bypass; Obesity; Sleeve gastrectomy