title: The quest to exploit the Auger effect in cancer radiotherapy - a reflective review.
abstract: To identify the emergence of the recognition of the potential of the Auger effect for clinical application, and after tracing the salient milestones towards that goal, to evaluate the status quo and future prospects. It was not until 40 years after the discovery of Auger electrons, that the availability of radioactive DNA precursors enabled the biological power, and the clinical potential, of the Auger effect to be appreciated. Important milestones on the path to clinical translation have been identified and reached, but hurdles remain. Nevertheless the potential is still evident, and there is reasonable optimism that the goal of clinical translation is achievable.
authors.affiliation: a Molecular Radiation Biology Laboratory , Peter MacCallum Cancer Centre.|b The Sir Peter MacCallum Department of Oncology , The University of Melbourne.|c School of Chemistry and Bio-21 Molecular Science and Biotechnology Institute , University of Melbourne , Melbourne , Australia.
authors.forename: Roger F
authors.initials: RF
authors.lastname: Martin
authors.affiliation: d Heinrich-Heine-University Düsseldorf , Germany.|e Brookhaven National Laboratory , Upton , NY , USA.
authors.forename: Ludwig E
authors.initials: LE
authors.lastname: Feinendegen
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004583:Electrons / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D016896:Treatment Outcome
keywords: Auger electrons; Auger emitters; Auger endoradiotherapy; DNA double-strand breaks