title: Formation and characterization of pseudo-polyrotaxanes based on poly(p-dioxanone) and cyclodextrins.
abstract: Novel pseudo-polyrotaxanes (PPRs) consisting of poly(p-dioxanone) (PPDO) and cyclodextrins (CDs) were obtained via heat-cool (H-C) cycles. The optimum preparation condition for achieving the highest yield was investigated, which was selected as follow: 3 times H-C cycles in 72 h of PPDO and CDs dissolved in DMF at 60 °C. The PPRs were further characterized by using wide-angle X-ray diffraction (WAXD), NMR, FT-IR, and thermogravimetric analysis (TGA). It was found that PPDO could be wrapped by CDs units. Compare to the single PPDO chain, the PPRs have better thermal stability. Moreover, the hydrophilicity of PPRs is also enhanced significantly determined by the water static contact angle tests. In addition, hydrolytic degradation experiments showed that the PPRs had unique degradation behaviors. The construction of the PPRs based on the PPDO and CDs would further expand the application of PPDO as biomaterials.
authors.affiliation: College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin 300457, PR China.
authors.forename: Liyuan
authors.initials: L
authors.lastname: Li
authors.affiliation: College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin 300457, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin 300457, PR China.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Xia
authors.affiliation: College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin 300457, PR China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wei
authors.affiliation: College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin 300457, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin 300457, PR China. Electronic address: guomj@tust.edu.cn.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Fan
authors.affiliation: College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin 300457, PR China. Electronic address: zhifan@tust.edu.cn.
authors.forename: Minjie
authors.initials: M
authors.lastname: Guo
mesh_terms: D003080:Cold Temperature; D003505:Cyclodextrins / Q000737:chemistry*; D004146:Dioxanes / Q000737:chemistry*; D006358:Hot Temperature; D006868:Hydrolysis; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D011108:Polymers / Q000737:chemistry*; D043862:Rotaxanes / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D003505:Cyclodextrins; D004146:Dioxanes; D011108:Polymers; D043862:Rotaxanes; C079733:poly-4-dioxan-2-one
keywords: 1,4-Dioxan-2-one (PubChem CID: 18233); Cyclodextrin; Degradation; Hydrophilicity; Poly(p-dioxanone); Pseudo-polyrotaxanes; α-Cyclodextrin (PubChem CID: 444913); β-Cyclodextrin (PubChem CID: 444041); γ-Cyclodextrin (PubChem CID: 5287407)