title: MiR-1180 promotes apoptotic resistance to human hepatocellular carcinoma via activation of NF-κB signaling pathway.
abstract: Apoptosis resistance in human hepatocellular carcinoma (HCC) is a significant factor in carcinogenesis. Therefore, understanding the molecular mechanisms involved in apoptosis resistance is crucial for developing anticancer therapies. Importantly, small non-coding microRNAs (miRNAs) have been reported as key biomarkers for detecting tumour onset and progression. In the present study, we demonstrate that miR-1180 is upregulated in HCC. Ectopic expression of miR-1180 has an anti-apoptotic effect in HCC, while miR-1180 inhibition increases cell apoptosis, both in vitro and in vivo. Moreover, our results show that miR-1180 directly targets key inhibitors of the nuclear factor (NF)-κB signaling pathway (i.e., OTUD7B and TNIP2) and the pro-apoptotic Bcl-2 associated death promoter (BAD) protein by post-transcriptional downregulation. Therefore, the anti-apoptotic function of miR-1180 in HCC may occur through NF-κB pathway activation via downregulation of its negative regulators. In conclusion, our study reveals the critical role of miR-1180 during apoptosis resistance in HCC.
authors.affiliation: Department of Interventional Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, P.R. China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Tan
authors.affiliation: Organ Transplantation Center, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Linwei
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Anorectal &Hernial Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, P.R. China.
authors.forename: Jinfu
authors.initials: J
authors.lastname: Tan
authors.affiliation: Department of Nuclear Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, P.R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University. Kowloon Tong, Hong Kong, S.A.R., P.R. China.|Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Shenzhen Research Institute and Continuing Education, Shenzhen 518000, P.R. China.
authors.forename: William Chi-shing
authors.initials: WC
authors.lastname: Tai
authors.affiliation: Department of Biochemistry, University of Leicester, Leicester, UK.
authors.forename: Shiqiu
authors.initials: S
authors.lastname: Xiong
authors.affiliation: Department of Interventional Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Interventional Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, P.R. China.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Interventional Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, P.R. China.|Department of Medical Oncology, the First Affiliated Hospital of Sun Yat-sen University. Guangzhou 510080, P.R. China.
authors.forename: Heping
authors.initials: H
authors.lastname: Li
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D017209:Apoptosis / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics*; D063646:Carcinogenesis / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D015536:Down-Regulation; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics; D051025:bcl-Associated Death Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C494819:BAD protein, human; D014408:Biomarkers, Tumor; C000613368:MIRN1180 microRNA, human; D035683:MicroRNAs; D016328:NF-kappa B; C434062:TNIP2 protein, human; D051025:bcl-Associated Death Protein; D010450:Endopeptidases; C476458:OTUD7B protein, human