title: Flexible Octopus-Shaped Hydrogel Particles for Specific Cell Capture.
abstract: Multiarm hydrogel microparticles with varying geometry are fabricated to specifically capture cells expressing epithelial cell adhesion molecule. Results show that particle shape influences cell-capture efficiency due to differences in surface area, hydrodynamic effects, and steric constraints. These findings can lead to improved particle design for cell separation and diagnostic applications.
authors.affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
authors.forename: Lynna
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
authors.forename: Harry Z
authors.initials: HZ
authors.lastname: An
authors.affiliation: General Fluidics, 34 Anderson St., Ste 5, Boston, MA 02114, USA.
authors.forename: Ramin
authors.initials: R
authors.lastname: Haghgooie
authors.affiliation: Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, MA 02129, USA.
authors.forename: Aaron T
authors.initials: AT
authors.lastname: Shank
authors.affiliation: Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, MA 02129, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Martel
authors.affiliation: Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, MA 02129, USA.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Toner
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Doyle
mesh_terms: D000906:Antibodies / Q000378:metabolism; D045744:Cell Line, Tumor; D002469:Cell Separation / Q000379:methods*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D044085:Microfluidics
chemical_list: D000906:Antibodies; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: cell capture; circulating tumor cells; hydrogels; microfluidics; microparticles