title: Antioxidant and Antifatigue Properties of the Aqueous Extract of Moringa oleifera in Rats Subjected to Forced Swimming Endurance Test.
abstract: The effects of the aqueous extract of Moringa oleifera on swimming performance and related biochemical parameters were investigated in male Wistar rats (130-132 g). Four groups of rats (16 per group) were fed a standard laboratory diet and given distilled water, 100, 200, or 400 mg/kg of extract, respectively, for 28 days. On day 28, 8 rats from each group were subjected to the forced swimming test with tail load (10% of body weight). The remaining 8 rats per group were subjected to the 90-minute free swim. Maximum swimming time, glycemia, lactamia, uremia, triglyceridemia, hepatic and muscle glycogen, hematological parameters, and oxidative stress parameters (superoxide dismutase, catalase, reduced glutathione, and malondialdehyde) were measured. Results. M. oleifera extract increased maximum swimming time, blood hemoglobin, blood glucose, and hepatic and muscle glycogen reserves. The extract also increased the activity of antioxidant enzymes and decreased the blood concentrations of malondialdehyde. Furthermore, it decreased blood concentrations of lactate, triglycerides, and urea. In conclusion, the antifatigue properties of M. oleifera extract are demonstrated by its ability to improve body energy stores and tissue antioxidant capacity and to reduce the tissue build-up of lactic acid.
authors.affiliation: Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P. O. Box 812, Yaoundé, Cameroon.
authors.forename: Bonoy
authors.initials: B
authors.lastname: Lamou
authors.affiliation: Department of Animal Biology and Physiology, Faculty of Science, University of Buea, P. O. Box 63, Yaoundé, Cameroon.
authors.forename: Germain Sotoing
authors.initials: GS
authors.lastname: Taiwe
authors.affiliation: Department of Biology and Sport Education, National Institute of Youth and Sports, P. O. Box 1016, Yaoundé, Cameroon.
authors.forename: André
authors.initials: A
authors.lastname: Hamadou
authors.affiliation: Department of Biology and Sport Education, National Institute of Youth and Sports, P. O. Box 1016, Yaoundé, Cameroon.
authors.lastname: Abene
authors.affiliation: Department of Biology and Sport Education, National Institute of Youth and Sports, P. O. Box 1016, Yaoundé, Cameroon.
authors.forename: Justin
authors.initials: J
authors.lastname: Houlray
authors.affiliation: Department of Animal Biology and Physiology, Faculty of Science, University of Buea, P. O. Box 63, Yaoundé, Cameroon.
authors.forename: Mahamat Mey
authors.initials: MM
authors.lastname: Atour
authors.affiliation: Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P. O. Box 812, Yaoundé, Cameroon.
authors.forename: Paul Vernyuy
authors.initials: PV
authors.lastname: Tan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D005221:Fatigue / Q000188:drug therapy* / Q000503:physiopathology*; D005247:Feeding Behavior / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D029588:Moringa oleifera / Q000737:chemistry*; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010807:Physical Endurance / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D017208:Rats, Wistar; D013550:Swimming
chemical_list: D000975:Antioxidants; D010936:Plant Extracts