title: A Shape-Memory DNA-Based Hydrogel Exhibiting Two Internal Memories.
abstract: The synthesis of a shape-memory acrylamide-DNA hydrogel that includes two internal memories is introduced. The hydrogel is stabilized, at pH 7.0, by two different pH-responsive oligonucleotide crosslinking units. At pH 10.0, one of the T-A⋅T triplex DNA bridging units is dissociated, resulting in the dissociation of the hydrogel into a shapeless quasi-liquid state that includes the other oligonucleotide bridges as internal memory. Similarly, at pH 5.0, the second type of bridges is separated, through the formation of C-G⋅C(+) triplex units to yield the shapeless quasi-liquid state that includes the other oligonucleotide bridges as internal memory. By reversible pH triggering of the hydrogel between the values 10.0⇔7.0⇔5.0, the two internal memories cycle the material across shaped hydrogel and shapeless quasi-liquid states. The two memories enable the pH-dictated formation of two different hydrogel structures.
authors.affiliation: Institute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Institute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Guo
authors.affiliation: Institute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Kahn
authors.affiliation: Institute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Aleman-Garcia
authors.affiliation: Institute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel. willnea@vms.huji.ac.il.
authors.forename: Itamar
authors.initials: I
authors.lastname: Willner
mesh_terms: D004247:DNA / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration
chemical_list: D020100:Hydrogels; D004247:DNA
keywords: DNA; gels; nanostructures; polymers; shape-memory materials