title: Silent information regulator T1 in aqueous humor of patients with cataract.
abstract: OBJECTIVE
  Silent information regulator T1 (SIRT1), a member of the sirtuin family, has a preventive role in various ocular diseases. We evaluated the relations between the aqueous humor level of SIRT1 and age, sex, systemic diseases, the severity of lens opacity, and other factors.
  
  
  METHODS
  This study was conducted at a university teaching hospital in Tokyo, Japan.
  
  
  METHODS
  This study was designed based on the consecutive case series.
  
  
  METHODS
  Aqueous humor samples were obtained from 29 eyes of the 21 consecutive patients undergoing surgery for age-related cataract (ARC). SIRT1 levels were determined by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Aqueous humor levels of SIRT1 showed a positive correlation with visual acuity (logarithm of the minimum angle of resolution) and with the severity of nuclear cataract (r=0.32 and 0.30, respectively, P<0.05). However, only visual acuity was correlated with SIRT1 according to the stepwise multiple regression analysis (P<0.05).
  
  
  CONCLUSIONS
  These findings suggest that SIRT1 may have an effect on the formation of ARC, acting as a defensive factor against ARC.
authors.affiliation: Department of Ophthalmology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Kondo
authors.affiliation: Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Goto
authors.affiliation: Department of Ophthalmology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Mimura
authors.affiliation: Department of Ophthalmology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Matsubara
keywords: SIRT1; cataract surgery; ocular aging; oxidative stress; resveratrol; sirtuin