title: Association of polymorphisms hOGGI rs1052133 and hMUTYH rs3219472 with risk of nasopharyngeal carcinoma in a Chinese population.
abstract: This case-control study investigates the possible relationships between the single-nucleotide polymorphisms rs1052133 in the human 8-oxoguanine DNA glycosylase 1 (hOGG1) gene and rs3219472 in the human MutY glycosylase homologue (hMUTYH) gene and the risk of nasopharyngeal carcinoma (NPC). The two polymorphisms were genotyped in 488 unrelated NPC patients and 573 cancer-free controls. Genotype GG at rs1052133 was associated with significantly lower NPC risk than genotypes GC + CC (odds ratio [OR] 0.770, 95% confidence interval [CI] 0.595-0.996, P=0.012). In subgroup analyses, subjects with genotype GG at rs1052133 were at lower risk of NPC than those with GC or CC among individuals older than 40 years (OR 0.706, 95% CI 0.524-0.950), women (OR 0.571, 95% CI 0.337-0.968), and those with no smoking history (OR 0.634, 95% CI 0.463-0.868). No significant association was seen between polymorphisms at hMUTYH rs3219472 and the risk of NPC. However, gene-gene interaction analysis showed that subjects with genotype CC at rs1052133 and genotype AA at rs3219472 (CC/AA) were at 2.887-fold higher risk of NPC than those with GG/GG, 3.183-fold higher risk than those with GG/GA, and 3.392-fold higher risk than those with GG/AA. Our results suggest that hOGG1 rs1052133 polymorphism may play an important role in NPC pathogenesis, especially among women, >40 years old, and those with no smoking history. The hMUTYH rs3219472 polymorphism may interact with hOGG1 rs1052133 polymorphism to influence susceptibility to NPC.
authors.affiliation: Guangxi Key Laboratory for High-Incidence Tumor Prevention and Treatment, Experimental Center of Medical Science of Guangxi Medical University, Nanning, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Graduate School of Guangxi Medical University, Nanning, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Graduate School of Guangxi Medical University, Nanning, People's Republic of China.
authors.forename: Xunzhao
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Graduate School of Guangxi Medical University, Nanning, People's Republic of China.
authors.forename: Mengwei
authors.initials: M
authors.lastname: Yao
authors.affiliation: Graduate School of Guangxi Medical University, Nanning, People's Republic of China.
authors.forename: Sisi
authors.initials: S
authors.lastname: Ning
authors.affiliation: Department of Head and Neck Tumor Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, People's Republic of China.
authors.forename: Zhengbo
authors.initials: Z
authors.lastname: Wei
keywords: base excision repair pathway; human 8-oxoguanine DNA glycosylase 1; human MutY glycosylase homologue; nasopharyngeal carcinoma; single-nucleotide polymorphism