title: [Progress of Long Non-coding RNAs in Non-small Cell Lung Cancer].
abstract: Lung cancer related death is the most common cause of cancer death worldwide. Non-coding RNA has no protein coding capacity, but can play roles in a variety of biology. Long non-coding RNA (lncRNA) is at least 200 nt long. A variety of lncRNAs could promote or inhibit tumor development and progression in many tumors, including non-small cell lung cancer (NSCLC). Due to their fundamental role in regulating gene expression, they involve in biological mechanism of the tumor, and so they are expected to be new cancer biomarkers. In this review, we emphasized the roles of lncRNAs in NSCLC, and discuss them as diagnostic and prognostic markers and as therapeutic targets.
authors.affiliation: Department of Medical Clinical Laboratory, Tianjin Medical University General Hospital, 300052 Tianjin, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Medical Clinical Laboratory, Tianjin Medical University General Hospital, 300052 Tianjin, China.
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Hu
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*
chemical_list: D062085:RNA, Long Noncoding