title: EMT: Matter of Life or Death?
abstract: TGF-β is long considered a "protean" cytokine in cancer, changing its role from anti- to pro-tumorigenic in a context-dependent manner. In this issue of Cell, David et al. use mouse models of pancreatic cancer to shed light on the mechanistic basis of how TGF-β-induced EMT is coupled to either apoptosis or tumor progression.
authors.affiliation: Sheikh Ahmed Pancreatic Cancer Research Center, Departments of Pathology and Translational Molecular Pathology, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Sonal
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Sheikh Ahmed Pancreatic Cancer Research Center, Departments of Pathology and Translational Molecular Pathology, UT MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: amaitra@mdanderson.org.
authors.forename: Anirban
authors.initials: A
authors.lastname: Maitra
mesh_terms: D000818:Animals; D044584:Carcinoma, Ductal / Q000235:genetics*; D058750:Epithelial-Mesenchymal Transition; D053263:Gene Regulatory Networks; D010190:Pancreatic Neoplasms / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors*
chemical_list: D016212:Transforming Growth Factor beta