title: [Progress in studies on the role of β-catenin in regulating the self-renewal and pluripotency of embryonic stem cells].
abstract: Embryonic stem cells (ESCs) is one of the best cell types for regenerative medicine. It is derived from inner cell mass of the blastocyst stage and characterized by self-renewal and pluripotency, which are regulated by kinds of signal molecules, such as the Wnt/β-catenin signaling pathway. β-catenin is a multifunctional protein and plays a key role in Wnt/β-catenin signaling pathway. β-catenin involves self-renewal of ESCs and promotes the differentiation of ESCs into three primary germ layers in space and time. Elucidating the mechanisms of β-catenin in regulating the self-renewal and pluripotency of ESCs will pave the way to use it in research and application.
authors.affiliation: Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha 410078, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha 410078, China.
authors.forename: Xingxiang
authors.initials: X
authors.lastname: Duan
authors.affiliation: National Engineering Research Center of Human Stem Cells, Changsha 410205, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yu
authors.affiliation: Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha 410078; National Engineering Research Center of Human Stem Cells, Changsha 410205, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
mesh_terms: D001755:Blastocyst / Q000166:cytology; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000502:physiology*
chemical_list: D051176:beta Catenin