title: Changes in ocular biometry and anterior chamber parameters after pharmacologic mydriasis and peripheral iridotomy in primary angle closure suspects.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effects of pharmacologic mydriasis and Peripheral Iridotomy (PI) on ocular biometry and anterior chamber parameters in primary angle closure suspects.
  
  
  METHODS
  In this prospective interventional case series, 21 primary angle closure suspects were enrolled. Intraocular pressure, refraction, ocular biometry (Lenstar, LS900), and anterior chamber parameters (Pentacam HR) were measured at four occasions: before PI (before and after mydriasis with phenylephrine) and two weeks after PI (before and after mydriasis). The study was conducted on both eyes and only one eye per patient, in random, was included in the analysis.
  
  
  RESULTS
  The mean age of the participants was 60±7 years and 17 (81%) were female. There were no significant differences in intraocular pressure, refraction, keratometry, biometric and anterior chamber parameters between groups, except for anterior chamber volume, which showed increments with PI and mydriasis. The corresponding values for anterior chamber volume were as follows: 88.2±13.7mm(3) before PI, undilated; 106.3±18.8 before PI, dilated; 99.0±14.6 after PI, undilated, and 107.4±16.5 after PI, dilated (P<0.001).
  
  
  CONCLUSIONS
  This study showed no change in the ocular biometric and anterior chamber parameters including iridocorneal angle after PI and/or pharmacologic mydriasis except for increments in anterior chamber volume. This factor has the potential to be used as a numerical proxy for iris position in evaluating and monitoring patients with primary angle closure suspects after PI.
authors.affiliation: Poostchi Eye Research Centre, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Truhelsen Eye Institute, University of Nebraska Medical Centre, Omaha, USA.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Razeghinejad
authors.affiliation: Poostchi Eye Research Centre, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Lashkarizadeh
authors.affiliation: Poostchi Eye Research Centre, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: norozzadeh@gmail.com.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Nowroozzadeh
authors.affiliation: Poostchi Eye Research Centre, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Yazdanmehr
mesh_terms: D000368:Aged; D000867:Anterior Chamber / Q000503:physiopathology*; D001699:Biometry; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D032801:Iridectomy / Q000009:adverse effects / Q000379:methods; D008297:Male; D008875:Middle Aged; D009184:Mydriatics / Q000009:adverse effects*; D010656:Phenylephrine / Q000009:adverse effects*; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology
chemical_list: D009184:Mydriatics; D010656:Phenylephrine
keywords: Anterior chamber volume; Biometría ocular; Iridotomía periférica; Midriasis; Mydriasis; Narrow angle; Ocular biometry; Peripheral iridotomy; Volumen de la cámara anterior; Ángulo estrecho