title: Flucloxacillin does not achieve therapeutic cerebrospinal fluid levels against meticillin-sensitive Staphylococcus aureus in adults: A case report and review of the literature.
abstract: It is uncertain whether flucloxacillin achieves therapeutic concentrations against meticillin-sensitive Staphylococcus aureus (MSSA) in cerebrospinal fluid (CSF). In this study, plasma and CSF concentrations of flucloxacillin and vancomycin in an adult patient were compared. Unlike vancomycin, the flucloxacillin CSF level was not therapeutic. Flucloxacillin monotherapy should be used with caution for MSSA central nervous system infection in adults.
authors.affiliation: Department of Infectious Diseases, Royal Brisbane and Women's Hospital, Herston, QLD 4029, Australia. Electronic address: christopher.chew@doctors.org.uk.
authors.forename: Rusheng
authors.initials: R
authors.lastname: Chew
authors.affiliation: Department of Infectious Diseases, Royal Brisbane and Women's Hospital, Herston, QLD 4029, Australia.
authors.forename: Marion L
authors.initials: ML
authors.lastname: Woods
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D005436:Floxacillin / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D005436:Floxacillin; D014640:Vancomycin
keywords: Central nervous system infection; Cerebrospinal fluid; Drug levels; Flucloxacillin; MSSA