title: Disorder in Milk Proteins: α-Lactalbumin. Part B. A Multifunctional Whey Protein Acting as an Oligomeric Molten Globular "Oil Container" in the Anti-Tumorigenic Drugs, Liprotides.
abstract: This is a second part of the three-part article from a series of reviews on the abundance and roles of intrinsic disorder in milk proteins. We continue to describe α-lactalbumin, a small globular Ca2+-binding protein, which besides being one of the two components of lactose synthase that catalyzes the final step of the lactose biosynthesis in the lactating mammary gland, possesses a multitude of other functions. In fact, recent studies indicated that some partially folded forms of this protein possess noticeable bactericidal activity and other forms might be related to induction of the apoptosis of tumor cells. In its anti-tumorigenic function, oligomeric α-lactalbumin serves as a founding member of a new family of anticancer drugs termed liprotides (for lipids and partially denatured proteins), where an oligomeric molten globular protein acts as an "oil container" or cargo for the delivery of oleic acid to the cell membranes.
authors.affiliation: Department of Molecular Medicine, College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, MDC3540, Tampa, FL 33612, USA. vuversky@health.usf.edu.
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Uversky
authors.forename: Serge E
authors.initials: SE
authors.lastname: Permyakov
authors.forename: Leonid
authors.initials: L
authors.lastname: Breydo
authors.forename: Elrashdy M
authors.initials: EM
authors.lastname: Redwan
authors.forename: Hussein A
authors.initials: HA
authors.lastname: Almehdar
authors.affiliation: Institute for Biological Instrumentation of the Russian Academy of Sciences, Institutskaya str., 7, Pushchino, Moscow region 142290, Russia. epermyak@yandex.ru.
authors.forename: Eugene A
authors.initials: EA
authors.lastname: Permyakov
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism; D004198:Disease Susceptibility; D006801:Humans; D007768:Lactalbumin / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D007785:Lactose / Q000096:biosynthesis; D008894:Milk Proteins / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D055503:Protein Multimerization / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002352:Carrier Proteins; D008894:Milk Proteins; D007768:Lactalbumin; D007785:Lactose