title: Iron-Catalyzed Dehydration of Aldoximes to Nitriles Requiring Neither Other Reagents Nor Nitrile Media.
abstract: The dehydration of aldoximes is an environmentally benign reaction affording the desired nitrile and water as a by-product. However, most of the reported catalytic dehydration reactions of aldoximes require a solvent containing nitrile to synthesize the corresponding nitrile compounds. Inspired by recent reports on the enzymatic synthesis under nitrile-free conditions, we here describe that a simple iron salt catalyzes the dehydration of aldoximes requiring neither other reagents nor nitrile media. Our method can be applied to the one-pot synthesis of nitiriles from aldehydes.
authors.affiliation: Department of Material Chemistry, Faculty of Science and Technology, Ryukoku University, Seta, Otsu, Shiga, 520-2194, Japan. hyodo@rins.ryukoku.ac.jp.
authors.forename: Kengo
authors.initials: K
authors.lastname: Hyodo
authors.affiliation: Department of Material Chemistry, Faculty of Science and Technology, Ryukoku University, Seta, Otsu, Shiga, 520-2194, Japan.
authors.forename: Saki
authors.initials: S
authors.lastname: Kitagawa
authors.affiliation: Department of Material Chemistry, Faculty of Science and Technology, Ryukoku University, Seta, Otsu, Shiga, 520-2194, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamazaki
authors.affiliation: Department of Material Chemistry, Faculty of Science and Technology, Ryukoku University, Seta, Otsu, Shiga, 520-2194, Japan.
authors.forename: Kingo
authors.initials: K
authors.lastname: Uchida
mesh_terms: D002384:Catalysis; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D010091:Oximes / Q000737:chemistry*
chemical_list: D009570:Nitriles; D010091:Oximes; D007501:Iron
keywords: aldehydes; aldoximes; dehydration; iron catalyst; nitrile synthesis