title: [Homologous recombination among bacterial genomes: the measurement and identification].
abstract: Homologous recombination is one of important sources in shaping the bacterial population diversity, which disrupts the clonal relationship among different lineages through horizontal transferring of DNA-segments. As consequence of blurring the vertical inheritance signals, the homologous recombination raises difficulties in phylogenetic analysis and reconstruction of population structure. Here we discuss the impacts of homologous recombination in inferring phylogenetic relationship among bacterial isolates, and summarize the tools and models separately used in recombination measurement and identification. We also highlight the merits and drawbacks of various approaches, aiming to assist in the practical application for the analysis of homologous recombination in bacterial evolution research.
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
authors.forename: Xian-wei
authors.initials: XW
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
authors.forename: Rui-fu
authors.initials: RF
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
authors.forename: Yu-jun
authors.initials: YJ
authors.lastname: Cui
mesh_terms: D001419:Bacteria / Q000145:classification / Q000235:genetics*; D005075:Biological Evolution; D019295:Computational Biology / Q000379:methods; D022761:Gene Transfer, Horizontal / Q000235:genetics; D014644:Genetic Variation; D005828:Genetics, Population; D016680:Genome, Bacterial / Q000235:genetics*; D059765:Homologous Recombination; D010802:Phylogeny; D013045:Species Specificity