title: In vivo anti-inflammatory activities of the essential oil from Radix Angelicae dahuricae.
abstract: Although Radix Angelicae dahuricae (Angelica) has been traditionally used in patients with rheumatism arthralgia, its bioactive ingredients remain to be determined. In this study, the essential oil extract of Radix Angelicae dahuricae (EOAD) was assessed for its anti-inflammatory activities against xylene-induced acute ear swelling and carrageenan-induced acute paw edema in mice as well as its anti-inflammatory and immunomodulating properties in Freund's complete adjuvant (FCA)-induced arthritis in rats. We found that EOAD at 100 mg/kg significantly alleviated xylene-induced ear swelling and carrageenan-induced paw edema in mice. Moreover, in the FCA-induced rat arthritis model, EOAD significantly improved hind paw swelling, lowered the adjuvant arthritis score, mitigated synovial hyperplasia, inflammatory cell infiltration, and cartilage destruction in the ankle joint, and reduced the serum levels of inflammatory mediators such as nitric oxide, tumor necrosis factor-α, and prostaglandin E2 as well as serum nitric oxide synthase activity. These findings support the fact that the essential oil extract of Angelica contains important active constituents responsible for its anti-inflammatory activities and therefore help to understand the phytotherapeutic effects of Angelica in the treatment of aseptic inflammation.
authors.affiliation: Department of Pharmacology, College of Pharmacy, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin, Jilin, People's Republic of China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, College of Pharmacy, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin, Jilin, People's Republic of China.
authors.forename: Jingbo
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Pharmacology, College of Pharmacy, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin, Jilin, People's Republic of China.
authors.forename: He
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Neurology, People's Hospital of Jilin City, Jilin, Jilin, People's Republic of China.
authors.forename: Xue
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Neurology, Affiliated Hospital, Beihua University, No. 12 Jiefang Middle Road, Chuanying District, Jilin, Jilin, People's Republic of China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Pharmacology, College of Pharmacy, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin, Jilin, People's Republic of China. 644257703@qq.com.
authors.forename: Jianguang
authors.initials: J
authors.lastname: Chen
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000627:therapeutic use*; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; D010936:Plant Extracts
keywords: Adjuvant arthritis; Inflammation; Nitric oxide; Prostaglandin E2; Radix Angelicae dahuricae