title: Psoriasis-associated fatigue: pathogenesis, metrics, and treatment.
abstract: Fatigue, a substantial symptom of psoriasis, is triggered by complex interactions of inflammation in psoriatic disease, both directly via inflammatory cytokines and indirectly via psychological and physiological factors. We provide data and observations that highlight the importance of qualifying and quantifying fatigue among patients with psoriasis and psoriatic arthritis and underscore the need to develop novel therapeutics to target this debilitating element of a multisystem disease.
authors.affiliation: Department of Medicine (Dermatology), Albert Einstein College of Medicine, Bronx, New York, USA.
authors.forename: Jamie
authors.initials: J
authors.lastname: Rosen
authors.affiliation: Department of Medicine (Dermatology), Albert Einstein College of Medicine, Bronx, New York, USA.
authors.forename: Angelo
authors.initials: A
authors.lastname: Landriscina
authors.affiliation: Department of Dermatology, George Washington School of Medicine and Health Sciences, Washington, DC, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Friedman
mesh_terms: D015535:Arthritis, Psoriatic / Q000150:complications* / Q000473:pathology / Q000523:psychology; D016207:Cytokines / Q000378:metabolism; D005221:Fatigue / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000473:pathology; D011565:Psoriasis / Q000150:complications* / Q000473:pathology / Q000523:psychology
chemical_list: D016207:Cytokines