title: Acute toxicity, antiedematogenic activity, and chemical constituents of Palicourea rigida Kunth.
abstract: The phytochemical study of the leaves, roots, and flowers of Palicourea rigida led to the isolation of the triterpenes betulinic acid (1) and lupeol (2), the diterpene phytol (3), and the iridoid glycosides sweroside (4) and secoxyloganin (5). These compounds were identified using NMR 1H and 13C and comparing the spectra with published data. We studied the antiedematogenic activity of crude extracts from the organs, and of different fractions, in mice and found that the n-hexane fraction of the leaf extract significantly inhibited the ear edema resulting from croton oil administration. The crude extract from leaves was not acutely toxic to the mice.
authors.forename: Vanessa G
authors.initials: VG
authors.lastname: Alves
authors.forename: Elisa A
authors.initials: EA
authors.lastname: da Rosa
authors.forename: Laura L M
authors.initials: LL
authors.lastname: de Arruda
authors.forename: Bruno A
authors.initials: BA
authors.lastname: Rocha
authors.forename: Ciomar A
authors.initials: CA
authors.lastname: Bersani Amado
authors.forename: Silvana M O
authors.initials: SM
authors.lastname: Santin
authors.forename: Armando M
authors.initials: AM
authors.lastname: Pomini
authors.forename: Cleuza C
authors.initials: CC
authors.lastname: da Silva
mesh_terms: D000818:Animals; D004487:Edema / Q000517:prevention & control*; D035264:Flowers / Q000737:chemistry; D057888:Iridoid Glucosides / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051379:Mice; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes / Q000737:chemistry / Q000494:pharmacology; D010836:Phytol / Q000737:chemistry / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry*; D023382:Toxicity Tests, Acute / Q000379:methods*; D016896:Treatment Outcome; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology; D000094062:Betulinic Acid; D000094042:Lupanes
chemical_list: D057888:Iridoid Glucosides; D053978:Pentacyclic Triterpenes; D010836:Phytol; D010936:Plant Extracts; D014315:Triterpenes; D000094062:Betulinic Acid; C059515:secoxyloganin; C049412:sweroside; C010480:lupeol; D000094042:Lupanes