title: Acute Posterior Multifocal Placoid Pigment Epitheliopathy Following Dengue Fever: A New Association for an Old Disease.
abstract: OBJECTIVE
  An association between antecedent viral illness and acute posterior multifocal placoid pigment epitheliopathy (APMPPE) has long been suspected. The authors propose dengue fever as a possible cause of APMPPE, based on three patients who travelled to or lived in endemic areas and had serologic evidence of prior exposure.
  
  
  METHODS
  Review of case records of two patients.
  
  
  RESULTS
  The index patient presented with APMPPE after her second confirmed dengue infection. A second patient with positive serology for dengue was subsequently identified, who had acute onset of posterior uveitis with APMPPE-like features. Dengue antibody titers were positive in both patients.
  
  
  CONCLUSIONS
  APMPPE may be another manifestation of dengue fever. Ophthalmologists should take travel histories and consider ordering dengue serology in appropriate patients with APMPPE even if fever is absent, and especially in patients with the possibility of attenuated systemic disease and a primarily immunologic reaction to subsequent exposure.
authors.affiliation: a Department of Ophthalmology , Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami , Florida , USA.
authors.forename: Raquel
authors.initials: R
authors.lastname: Goldhardt
authors.affiliation: a Department of Ophthalmology , Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami , Florida , USA.
authors.forename: Heena
authors.initials: H
authors.lastname: Patel
authors.affiliation: a Department of Ophthalmology , Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami , Florida , USA.
authors.forename: Janet L
authors.initials: JL
authors.lastname: Davis
mesh_terms: D000208:Acute Disease; D002833:Choroiditis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D003715:Dengue / Q000150:complications*; D005260:Female; D006801:Humans; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D000076082:Travel-Related Illness
keywords: Acute posterior multifocal placoid pigment epitheliopathy; arbovirus; dengue; hypersensitivity; uveitis