title: Modular Approach to 9-Monosubstituted Fluorene Derivatives Using Mo(V) Reagents.
abstract: Oxidative coupling using molybdenum(V) reagents provides fast access to highly functionalized 9-monosubstituted fluorenes. This synthetic approach is highly modular, is high yielding, and tolerates a variety of labile moieties, e.g. amides or iodo groups. The established protocol leads to promising precursors for pharmacologically important analogues of melatonin.
authors.affiliation: Johannes Gutenberg-University Mainz, Institute of Organic Chemistry , Duesbergweg 10-14, 55128 Mainz, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Franzmann
authors.affiliation: Johannes Gutenberg-University Mainz, Institute of Organic Chemistry , Duesbergweg 10-14, 55128 Mainz, Germany.
authors.forename: Simon
authors.initials: S
authors.lastname: Trosien
authors.affiliation: Johannes Gutenberg-University Mainz, Institute of Organic Chemistry , Duesbergweg 10-14, 55128 Mainz, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Schubert
authors.affiliation: Johannes Gutenberg-University Mainz, Institute of Organic Chemistry , Duesbergweg 10-14, 55128 Mainz, Germany.
authors.forename: Siegfried R
authors.initials: SR
authors.lastname: Waldvogel
mesh_terms: D020650:Combinatorial Chemistry Techniques; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents; D008550:Melatonin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D058451:Oxidative Coupling
chemical_list: D005449:Fluorenes; D007202:Indicators and Reagents; D008982:Molybdenum; D008550:Melatonin