title: Analysis of 27 Y-chromosomal STR haplotypes in a Han population of Henan province, Central China.
abstract: A total of 1225 unrelated Han males from Henan province were analyzed with the prototype Yfiler® Plus kit (Life Technologies, Thermo Fisher Scientific, Waltham, MA, USA). The calculated gene diversity (GD) values ranged from 0.3855 to 0.9673 for the DYS391 and DYS385a/b loci, respectively. The discriminatory capacity (DC) was 86.94 % with 1065 observed haplotypes using 17 Yfiler loci, by the addition of 10 Y-STRs to the Yfiler® Plus system, the DC was increased to 98.94 % while showing 1212 observed haplotypes. Among the new incorporated Y-STRs, DYS576, DYF387S1, DYS518, DYS627, and DYS449 were major contributors to enhancing discrimination. In the analysis of molecular variance, the Henan Han population clustered with Asian origin populations and showed significant differences from other reference populations. In this study, the improvement of adding additional Y-STR markers with the Yfiler® Plus kit provided substantially stronger discriminatory power in the Henan Han population.
authors.affiliation: Key Laboratory of Evidence Science (China University of Political Science and Law), Ministry of Education, 25 Xitucheng Road, Beijing, 100088, People's Republic of China.|Collaborative Innovation Center of Judicial Civilization, 25 Xitucheng Road, Beijing, 100088, People's Republic of China.
authors.forename: Rufeng
authors.initials: R
authors.lastname: Bai
authors.affiliation: Xuchang Institute of Forensic Sciences, Public Security Bureau of Henan Province, Henan, 461000, People's Republic of China.
authors.forename: Yaju
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Xuchang Institute of Forensic Sciences, Public Security Bureau of Henan Province, Henan, 461000, People's Republic of China.
authors.forename: Juntao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Evidence Science (China University of Political Science and Law), Ministry of Education, 25 Xitucheng Road, Beijing, 100088, People's Republic of China.|Collaborative Innovation Center of Judicial Civilization, 25 Xitucheng Road, Beijing, 100088, People's Republic of China.
authors.forename: Meisen
authors.initials: M
authors.lastname: Shi
authors.affiliation: Department of Forensic Medicine, Huazhong University of Science and Technology, Tongji Medical College, Hubei, 430030, People's Republic of China. hongmeidong1@yeah.net.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Dong
authors.affiliation: Department of Radiology, First Affiliated Hospital, Medical College of Shantou University, Shantou, 515041, People's Republic of China. shuhuayue6699@163.com.
authors.forename: Shuhua
authors.initials: S
authors.lastname: Ma
authors.affiliation: Key Laboratory of Evidence Science (China University of Political Science and Law), Ministry of Education, 25 Xitucheng Road, Beijing, 100088, People's Republic of China.|Collaborative Innovation Center of Judicial Civilization, 25 Xitucheng Road, Beijing, 100088, People's Republic of China.
authors.forename: R F
authors.initials: RF
authors.lastname: Bai
authors.affiliation: Key Laboratory of Evidence Science (China University of Political Science and Law), Ministry of Education, 25 Xitucheng Road, Beijing, 100088, People's Republic of China.|Collaborative Innovation Center of Judicial Civilization, 25 Xitucheng Road, Beijing, 100088, People's Republic of China.
authors.forename: Ms
authors.initials: M
authors.lastname: Shi
mesh_terms: D002681:China; D041322:Chromosomes, Human, Y; D016172:DNA Fingerprinting; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D018895:Microsatellite Repeats
keywords: Haplotypes; Henan Han; Multidimensional scaling; Y-STR; Yfiler®Plus