title: Advances in plant-based inhibitors of P-glycoprotein.
abstract: Multidrug resistance (MDR) has emerged as the main problem in anti-cancer therapy. Although MDR involves complex factors and processes, the main pivot is the expression of multidrug efflux pumps. P-glycoprotein (P-gp) belongs to the family of adenosine triphosphate (ATP)-binding cassette (ABC) transporters. It functions in cellular detoxification, pumping a wide range of xenobiotic compounds out of the cell. An attractive therapeutic strategy for overcoming MDR is to inhibit the transport function of P-gp and thus, increase intracellular concentration of drugs. Recently, various types of P-gp inhibitors have been found and used in experiments. However, none of them has passed clinical trials due to their high side-effects. Hence, the search for alternatives, such as plant-based P-gp inhibitors have gained attention recently. Therefore, we give an overview of the source, function, structure and mechanism of plant-based P-gp inhibitors and give more attention to cancer-related studies. These products could be the future potential drug candidates for further research as P-gp inhibitors.
authors.affiliation: a Institute of Clinical Pharmacology, Anhui Medical University , Hefei , China .|b Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education , Hefei , China , and.|c Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine , Hefei , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
authors.affiliation: a Institute of Clinical Pharmacology, Anhui Medical University , Hefei , China .|b Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education , Hefei , China , and.|c Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine , Hefei , China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhou
authors.affiliation: a Institute of Clinical Pharmacology, Anhui Medical University , Hefei , China .|b Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education , Hefei , China , and.|c Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine , Hefei , China.
authors.forename: James
authors.initials: J
authors.lastname: Asenso
authors.affiliation: a Institute of Clinical Pharmacology, Anhui Medical University , Hefei , China .|b Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education , Hefei , China , and.|c Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine , Hefei , China.
authors.forename: Xiao-Dan
authors.initials: XD
authors.lastname: Yang
authors.affiliation: a Institute of Clinical Pharmacology, Anhui Medical University , Hefei , China .|b Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education , Hefei , China , and.|c Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine , Hefei , China.
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.affiliation: a Institute of Clinical Pharmacology, Anhui Medical University , Hefei , China .|b Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education , Hefei , China , and.|c Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine , Hefei , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000972:Antineoplastic Agents, Phytogenic
keywords: Multidrug resistance; P-glycoprotein; P-glycoprotein inhibitors; plant-based medicines