title: Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Angiogenesis: Potencial Clinical Application.
abstract: Mesenchymal stem cells (MSCs) are adult multipotent stem cells that are able to differentiate into multiple specialized cell types including osteocytes, adipocytes, and chondrocytes. MSCs exert different functions in the body and have recently been predicted to have a major clinical/therapeutic potential. However, the mechanisms of self-renewal and tissue regeneration are not completely understood. It has been shown that the biological effect depends mainly on its paracrine action. Furthermore, it has been reported that the secretion of soluble factors and the release of extracellular vesicles, such as exosomes, could mediate the cellular communication to induce cell-differentiation/self-renewal. This review provides an overview of MSC-derived exosomes in promoting angiogenicity and of the clinical relevance in a therapeutic approach.
authors.affiliation: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción Concepción, Chile.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Merino-González
authors.affiliation: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción Concepción, Chile.
authors.forename: Felipe A
authors.initials: FA
authors.lastname: Zuñiga
authors.affiliation: Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Department of Basic Sciences, Universidad del Bío-BíoChillán, Chile; Group of Research and Innovation in Vascular Health (GRIVAS Health)Chillán, Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: Escudero
authors.affiliation: Department of Physiopathology, Faculty of Biological Sciences, University of Concepción Concepción, Chile.
authors.forename: Valeska
authors.initials: V
authors.lastname: Ormazabal
authors.affiliation: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción Concepción, Chile.
authors.forename: Camila
authors.initials: C
authors.lastname: Reyes
authors.affiliation: MRC Centre for Transplantation, King's College London London, UK.
authors.forename: Estefanía
authors.initials: E
authors.lastname: Nova-Lamperti
authors.affiliation: Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland Brisbane, QLD, Australia.
authors.forename: Carlos
authors.initials: C
authors.lastname: Salomón
authors.affiliation: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of ConcepciónConcepción, Chile; Group of Research and Innovation in Vascular Health (GRIVAS Health)Chillán, Chile.
authors.forename: Claudio
authors.initials: C
authors.lastname: Aguayo
keywords: angiogenesis; extracellular vesicles; mesenchymal stem cell