title: The neglected role of copper ions in wound healing.
abstract: Wound healing is a complex biological process that aims to repair damaged tissue. Even though many biological and biochemical mechanisms associated with the steps of physiological wound healing are known, there is still significant morbidity and mortality due to dysregulation of physiological mechanisms. It might be useful to revise the activity of old players and their links with new, often neglected, molecular entities. This review revises new findings supporting the hypothesis that copper ions regulate the activity and/or the expression of proteins crucially involved in the wound repair process. A better understanding of these interactions might suggest potential new targets for therapeutic intervention on scars or non-healing wounds.
authors.affiliation: St. George's University, School of Medicine, West Indies, Grenada.
authors.forename: Allison Paige
authors.initials: AP
authors.lastname: Kornblatt
authors.affiliation: Department of Biomedical and Biotechnological Science, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy; Istituto Nazionale Biostrutture e Biosistemi (INBB) - Sezione Biomolecole, Consorzio Interuniversitario, Viale Medaglie d'Oro 305, 00136 Rome, Italy; Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici (C.I.R.C.M.S.B.), Via Celso Ulpiani 27, 70125 Bari, Italy. Electronic address: nicovigi@unict.it.
authors.forename: Vincenzo Giuseppe
authors.initials: VG
authors.lastname: Nicoletti
authors.affiliation: Center for Neural Science, New York University, 4 Washington Place, New York, 10003, NY, USA. Electronic address: at2340@nyu.edu.
authors.forename: Alessio
authors.initials: A
authors.lastname: Travaglia
mesh_terms: D000818:Animals; D003300:Copper / Q000378:metabolism*; D006801:Humans; D014945:Wound Healing / Q000502:physiology*
chemical_list: D003300:Copper
keywords: Angiogenesis; Copper; Inflammation; Metal ion homeostasis; Nerve Growth Factor; Would healing