title: Mitochondrial Dysfunction in Cancer and Neurodegenerative Diseases: Spotlight on Fatty Acid Oxidation and Lipoperoxidation Products.
abstract: In several human diseases, such as cancer and neurodegenerative diseases, the levels of reactive oxygen species (ROS), produced mainly by mitochondrial oxidative phosphorylation, is increased. In cancer cells, the increase of ROS production has been associated with mtDNA mutations that, in turn, seem to be functional in the alterations of the bioenergetics and the biosynthetic state of cancer cells. Moreover, ROS overproduction can enhance the peroxidation of fatty acids in mitochondrial membranes. In particular, the peroxidation of mitochondrial phospholipid cardiolipin leads to the formation of reactive aldehydes, such as 4-hydroxynonenal (HNE) and malondialdehyde (MDA), which are able to react with proteins and DNA. Covalent modifications of mitochondrial proteins by the products of lipid peroxidation (LPO) in the course of oxidative cell stress are involved in the mitochondrial dysfunctions observed in cancer and neurodegenerative diseases. Such modifications appear to affect negatively mitochondrial integrity and function, in particular energy metabolism, adenosine triphosphate (ATP) production, antioxidant defenses and stress responses. In neurodegenerative diseases, indirect confirmation for the pathogenetic relevance of LPO-dependent modifications of mitochondrial proteins comes from the disease phenotypes associated with their genetic alterations.
authors.affiliation: Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Torino 10125, Italy. giuseppina.barrera@unito.it.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Barrera
authors.affiliation: Dipartimento di Medicina e Scienze della Salute "V. Tiberio", Università del Molise, Campobasso 86100, Italy. gentilefabrizio@unimol.it.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Gentile
authors.affiliation: Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Torino 10125, Italy. stefania.pizzimenti@unito.it.
authors.forename: Stefania
authors.initials: S
authors.lastname: Pizzimenti
authors.affiliation: Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Torino 10125, Italy. rosangela.canuto@unito.it.
authors.forename: Rosa Angela
authors.initials: RA
authors.lastname: Canuto
authors.affiliation: Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Torino 10125, Italy. martina.daga@unito.it.
authors.forename: Martina
authors.initials: M
authors.lastname: Daga
authors.affiliation: Dipartimento di Medicina e Scienze della Salute "V. Tiberio", Università del Molise, Campobasso 86100, Italy. alessia.arcaro@unimol.it.
authors.forename: Alessia
authors.initials: A
authors.lastname: Arcaro
authors.affiliation: Dipartimento di Medicina e Scienze della Salute "V. Tiberio", Università del Molise, Campobasso 86100, Italy. giovanni.cetrangolo@unimol.it.
authors.forename: Giovanni Paolo
authors.initials: GP
authors.lastname: Cetrangolo
authors.affiliation: Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Napoli 80131, Italy. alessiolep@gmail.com.
authors.forename: Alessio
authors.initials: A
authors.lastname: Lepore
authors.affiliation: Dipartimento di Scienze e Tecnologia del Farmaco, Università di Torino, Torino 10125, Italy. carlo.ferretti@unito.it.
authors.forename: Carlo
authors.initials: C
authors.lastname: Ferretti
authors.affiliation: Dipartimento di Scienze e Tecnologia del Farmaco, Università di Torino, Torino 10125, Italy. chiara.dianzani@unito.it.
authors.forename: Chiara
authors.initials: C
authors.lastname: Dianzani
authors.affiliation: Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Torino 10125, Italy. giuliana.muzio@unito.it.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Muzio
keywords: cancer; fatty acid oxidation; lipoperoxidation products; mitochondria; neurodegenerative diseases