title: A Metal-Free Diverse Synthesis of Difluoromethylthioethers and Difluorobis(arylthio)methanes from RSX (X = SR, Cl, SO2Ph) and TMSCF2H.
abstract: Construction of difluoromethylthioethers (2) and difluorobis(arylthio)methanes (3) from RSX (X = SR, Cl, SO2Ph) and TMSCF2H in the absence of transition metals has been explored. The reaction is dramatically influenced by the nature of the base and the molar ratio of the reactants. Reactions between RSX and TMSCF2H in the presence of CsF provided 2 in good yields, whereas the reaction of RSX with TMSCF2H in the presence of t-BuOK afforded 3 in good yields. These protocols allow for convenient and efficient access to both difluoromethylthioethers and difluorobis(arylthio)methanes.
authors.affiliation: School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology , 205 Luoshi Road, Wuhan, 430070, China.
authors.forename: Jia-Bin
authors.initials: JB
authors.lastname: Han
authors.affiliation: School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology , 205 Luoshi Road, Wuhan, 430070, China.
authors.forename: Hua-Li
authors.initials: HL
authors.lastname: Qin
authors.affiliation: School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology , 205 Luoshi Road, Wuhan, 430070, China.
authors.forename: Su-Hong
authors.initials: SH
authors.lastname: Ye
authors.affiliation: College of Chemistry and Materials Science, Hubei Engineering University , Hubei, 432000, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.affiliation: School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology , 205 Luoshi Road, Wuhan, 430070, China.
authors.forename: Cheng-Pan
authors.initials: CP
authors.lastname: Zhang