title: Human Papillomavirus (HPV) L1 Serum Antibodies and the Risk of Subsequent Oral HPV Acquisition in Men: The HIM Study.
abstract: The role of antibody-mediated immunity in preventing newly acquired oral human papillomavirus (HPV) is not well understood. Among 1618 men participating in the HPV Infection in Men (HIM) Study, we evaluated oral rinses for HPV DNA and baseline sera for HPV-6, -11, -16, and -18 L1 antibodies. Thirty percent of men (486) were seropositive for ≥1 HPV type, and 25 men developed incident oral HPV infection (HPV-6 was detected in 7, HPV-11 in 0, HPV-16 in 17, and HPV-18 in 1). Cox models revealed that men with circulating antibodies to HPV-6, -11, -16, or -18 were not less likely to acquire type-specific oral HPV than men without antibodies (hazard ratio for the risk of acquiring HPV-6, -11, -16, or -18, 1.63; 95% confidence interval, .56-4.76).
authors.affiliation: Department of Cancer Epidemiology.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Pierce Campbell
authors.affiliation: Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore.
authors.forename: Raphael P
authors.initials: RP
authors.lastname: Viscidi
authors.affiliation: Department of Cancer Epidemiology.
authors.forename: B Nelson
authors.initials: BN
authors.lastname: Torres
authors.affiliation: Department of Biostatistics and Bioinformatics, Moffitt Cancer Center and Research Institute, Tampa, Florida.
authors.forename: Hui-Yi
authors.initials: HY
authors.lastname: Lin
authors.affiliation: Department of Biostatistics and Bioinformatics, Moffitt Cancer Center and Research Institute, Tampa, Florida.
authors.forename: William
authors.initials: W
authors.lastname: Fulp
authors.affiliation: Department of Cancer Epidemiology.
authors.forename: Martha
authors.initials: M
authors.lastname: Abrahamsen
authors.affiliation: Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, México.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Lazcano-Ponce
authors.affiliation: Department of Radiology and Oncology, School of Medicine, University of São Paulo Cancer Institute of the State of São Paulo, Brazil.
authors.forename: Luisa L
authors.initials: LL
authors.lastname: Villa
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Aimée R
authors.initials: AR
authors.lastname: Kreimer
authors.affiliation: Department of Cancer Epidemiology.
authors.forename: Anna R
authors.initials: AR
authors.lastname: Giuliano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology*; D001938:Brazil; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000209:etiology* / Q000276:immunology*; D027383:Papillomaviridae / Q000276:immunology*; D030361:Papillomavirus Infections / Q000150:complications* / Q000635:transmission*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D014481:United States; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral
keywords: HPV16; antibodies; men; oral HPV; serology