title: The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance.
abstract: Invasive aspergillosis has emerged as one of the most common life-threatening fungal disease of humans. The emergence of antifungal resistant pathogens represents a current and increasing threat to society. In turn, new strategies to combat fungal infection are urgently required. Fungal adaptations to stresses experienced within the human host are a prerequisite for the survival and virulence strategies of the pathogen. Here, we review the latest information on the signalling pathways in Aspergillus fumigatus that contribute to stress adaptations and virulence, while highlighting their potential as targets for the development of novel combinational antifungal therapies.
authors.affiliation: Plant Biology and Crop Science, Rothamsted Research, Harpenden, Hertfordshire, UK. neil.brown@rothamsted.ac.uk.
authors.forename: Neil A
authors.initials: NA
authors.lastname: Brown
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brasil. ggoldman@usp.br.
authors.forename: Gustavo H
authors.initials: GH
authors.lastname: Goldman
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000188:drug therapy; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D025141:Drug Resistance, Fungal; D054884:Host-Pathogen Interactions; D006801:Humans; D013312:Stress, Physiological / Q000502:physiology*; D014774:Virulence / Q000187:drug effects
chemical_list: D000935:Antifungal Agents
keywords: aspergillosis; cell wall stress; fungicide resistance; heat shock; hypoxia; osmotic stress; oxidative stress