title: Impact of parenchymal loss on renal function after laparoscopic partial nephrectomy under warm ischemia.
abstract: OBJECTIVE
  To elucidate the impact of renal parenchymal loss and the ischemic reperfusion injury (RI) on the renal function after laparoscopic partial nephrectomy (LPN) under warm ischemia (WI).
  
  
  METHODS
  Thirty-five patients with a single polar renal mass ≤4 cm and normal contralateral kidney underwent LPN. Transperitoneal LPN with WI using en bloc hilar occlusion was performed. The total differential renal function (T-DRF) using99mTc-dimercaptosuccinic acid was evaluated preoperatively and postoperatively over a period of 1 year. A special region of interest (ROI) was selected on the non-tumorous pole of the involved kidney, and was compared with the same ROI in the contralateral kidney. The latter comparison was defined as partial differential renal function (P-DRF). Any postoperative decline in the P-DRF of the operated kidney was attributed to the RI. Subtraction of the P-DRF decline from the T-DRF decline was attributed to the parenchymal loss caused by the resection of the tumor and suturing of the normal parenchyma.
  
  
  RESULTS
  The mean WI time was 22 min, and the mean weight of resected specimen was 18 g. The mean postoperative eGFR declined to 87 ml/min/1.73 m2from its baseline mean value of 97 ml/min/1.73 m2(p value = 0.075). Mean postoperative T-DRF and P-DRF of the operated kidney declined by 7 and 3 %, respectively.
  
  
  CONCLUSIONS
  After LPN of small renal mass, decline in renal function is primarily attributed to parenchymal loss caused by tumor resection and suturing of the normal parenchyma rather than the RI.
authors.affiliation: Department of Urology, Dubai Hospital, Dubai Health Authority, Dubai, UAE.|Department of Urology, University of Pécs Medical School, Pécs, Hungary.
authors.forename: Fariborz
authors.initials: F
authors.lastname: Bagheri
authors.affiliation: Department of Urology, University of Pécs Medical School, Pécs, Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Pusztai
authors.affiliation: Department of Urology, University of Pécs Medical School, Pécs, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Farkas
authors.affiliation: Department of Urology, University of Hospital of Patras, 26504, Rion, Patras, Greece. pkallidonis@yahoo.com.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Kallidonis
authors.affiliation: Department of Urology, PéterfySándor Street Hospital, Budapest, Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Buzogány
authors.affiliation: Department of Nuclear Medicine, University of Pécs Medical School, Pécs, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Szabó
authors.affiliation: Department of Research and Techniques, University of Pécs Medical School, Pécs, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Lantos
authors.affiliation: Diagnostic Center of Pécs, Pécs, Hungary.
authors.forename: Marianna
authors.initials: M
authors.lastname: Imre
authors.affiliation: Institute of Bioanalysis, University of Pécs Medical School, Pécs, Hungary.
authors.forename: Nelli
authors.initials: N
authors.lastname: Farkas
authors.affiliation: Department of Urology, University of Pécs Medical School, Pécs, Hungary.
authors.forename: Árpád
authors.initials: Á
authors.lastname: Szántó
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods*; D010865:Pilot Projects; D011446:Prospective Studies; D011877:Radionuclide Imaging / Q000379:methods; D052096:Warm Ischemia / Q000379:methods*; D055815:Young Adult
keywords: Laparoscopy; Parenchymal loss; Partial nephrectomy; Renal function; Warm ischemia