title: Prevalence and risk factors of postoperative delirium in elderly hip fracture patients.
abstract: OBJECTIVE
  To explore the risk factors associated with postoperative delirium (PD) in elderly patients following total hip arthroplasty (THA) for hip fracture.
  
  
  METHODS
  This prospective study enrolled elderly patients (≥ 65 years) with hip fractures who underwent THA under general anaesthesia, and who had a complete set of postoperative observations. Detailed medical history and perioperative characteristics were recorded. During the postoperative period, patients were assessed twice daily for PD using the Confusion Assessment Method.
  
  
  RESULTS
  A total of 572 patients were eligible for inclusion in the study. Of these, 120 patients (21.0%) were diagnosed with PD and 452 patients (79.0%) did not experience PD. Multivariate stepwise logistic regression analyses showed that older age, a history of stroke, lower albumin, higher blood glucose, higher total bilirubin, higher C-reactive protein, longer surgery duration and higher volume of red blood cell transfusions were independent risk factors for PD.
  
  
  CONCLUSIONS
  Correcting the modifiable risk factors might help prevent PD. Strategies might include nutritional support, tight blood glucose control, improvement of liver function, preoperative infection control and minimizing surgical injury or blood loss.
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China Department of Anaesthesiology and Critical Care Medicine, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Peiyu
authors.initials: P
authors.lastname: Jia
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Xuemin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China dr_jiangwei@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000768:Anesthesia, General / Q000379:methods; D018686:Anesthetics, Intravenous / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001803:Blood Transfusion; D002097:C-Reactive Protein / Q000378:metabolism; D000071257:Emergence Delirium / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D006620:Hip Fractures / Q000473:pathology / Q000601:surgery*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008874:Midazolam / Q000627:therapeutic use; D015999:Multivariate Analysis; D010384:Pelvic Bones / Q000293:injuries / Q000601:surgery; D011446:Prospective Studies; D012307:Risk Factors; D017409:Sufentanil / Q000627:therapeutic use
chemical_list: D018686:Anesthetics, Intravenous; D001786:Blood Glucose; D002097:C-Reactive Protein; D017409:Sufentanil; D008874:Midazolam; D001663:Bilirubin
keywords: Postoperative delirium; elderly patients; hip fracture; risk factors