title: [A mechanistic review of how hypoxic mircroenvironment regulates mammalian ovulation].
abstract: Mammalian ovulation is a complicated process that includes development of follicles, ovulation, formation of corpus luteum and luteolysis. The three different stages of the ovulation activity are affected by hypoxic microenvironment and hypoxia-induced factors (HIF), which play a crucial role in physiologyical processes, such as angiogenesis and inflammation. Although the process of ovulation has been well elucidated, the molecular mechanism regulated by hypoxia needs an in depth study. In this review, we summarize how hypoxic and HIF regulate gene expression during mammalian ovulation in order to provide a better understanding of ovulation mechanism, which may lay a theoretical basis for prevention and therapy of various ovarian diseases.
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors.forename: Bao-yun
authors.initials: BY
authors.lastname: Zhang
authors.affiliation: Sichuan TQLS Animal Husbandry Science and Technology Co.LTD, Mianyang 621000, China.
authors.forename: Guang-de
authors.initials: GD
authors.lastname: Feng
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiang
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors.forename: Yun-xia
authors.initials: YX
authors.lastname: Ma
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Chen
authors.affiliation: Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
authors.forename: Ming-xing
authors.initials: MX
authors.lastname: Chu
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors.forename: Ping-qing
authors.initials: P
authors.lastname: Wang
mesh_terms: D000818:Animals; D060833:Cellular Microenvironment / Q000502:physiology*; D005260:Female; D006801:Humans; D000860:Hypoxia; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D008322:Mammals / Q000378:metabolism / Q000502:physiology*; D006080:Ovarian Follicle / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D010060:Ovulation / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D051793:Hypoxia-Inducible Factor 1; D042461:Vascular Endothelial Growth Factor A