title: Proteostasis Maintenance of Cys-Loop Receptors.
abstract: The Cys-loop receptors play prominent roles in the nervous system. They include γ-aminobutyric acid type A receptors, nicotinic acetylcholine receptors, 5-hydroxytryptamine type-3 receptors, and glycine receptors. Proteostasis represents an optimal state of the cellular proteome in normal physiology. The proteostasis network regulates the folding, assembly, degradation, and trafficking of the Cys-loop receptors, ensuring their efficient functional cell surface expressions. Here, we summarize current advances about the protein biogenesis process of the Cys-loop receptors. Because operating on individual biogenesis steps influences the receptor cell surface level, manipulating the proteostasis network components can regulate the function of the receptors, representing an emerging therapeutic strategy for corresponding channelopathies.
authors.affiliation: Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
authors.forename: Yan-Lin
authors.initials: YL
authors.lastname: Fu
authors.affiliation: Center for Proteomics and Bioinformatics and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
authors.forename: Ya-Juan
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Electronic address: tingwei.mu@case.edu.
authors.forename: Ting-Wei
authors.initials: TW
authors.lastname: Mu
mesh_terms: D002462:Cell Membrane; D058466:Cysteine Loop Ligand-Gated Ion Channel Receptors / Q000737:chemistry* / Q000378:metabolism; D004705:Endocytosis / Q000235:genetics; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000378:metabolism; D006056:Golgi Apparatus / Q000737:chemistry / Q000378:metabolism; D017510:Protein Folding; D021381:Protein Transport / Q000235:genetics; D018079:Receptors, GABA / Q000737:chemistry* / Q000378:metabolism; D018009:Receptors, Glycine / Q000737:chemistry* / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000737:chemistry* / Q000378:metabolism; D044406:Receptors, Serotonin, 5-HT3 / Q000737:chemistry* / Q000378:metabolism
chemical_list: D058466:Cysteine Loop Ligand-Gated Ion Channel Receptors; D018079:Receptors, GABA; D018009:Receptors, Glycine; D011978:Receptors, Nicotinic; D044406:Receptors, Serotonin, 5-HT3
keywords: 5-HT(3)R; Assembly; Cys-loop receptors; ERAD; Endocytosis; Folding; GABA(A)R; Proteostasis; Trafficking; nAChR