title: Recreational physical activity and ovarian cancer risk in African American women.
abstract: The literature on recreational physical activity (RPA) and ovarian cancer risk is inconclusive and most studies of RPA and ovarian cancer have been conducted in white populations. This study is the first to investigate the association between RPA and ovarian cancer in an exclusively African American (AA) population. We analyzed data from an ongoing U.S. population-based, case-control study of AA women, which included 393 women recently diagnosed with invasive epithelial ovarian cancer (IEOC) and 611 controls. A baseline interview assessed RPA frequency, intensity, and duration. Each RPA intensity was assigned a metabolic equivalent of task (MET) value and MET-min/week were calculated. Unconditional multivariable logistic regression was performed to investigate associations between RPA and IEOC risk. Compared with sedentary women, predominantly mild intensity RPA was significantly inversely associated with IEOC risk for women reporting above median (>297) MET-min/week (odds ratio [OR] = 0.52; 95% confidence interval [CI]: 0.34, 0.78) and nonsignificantly for <297 MET-min/week (OR = 0.71; 95% CI: 0.44, 1.12). Predominantly moderate intensity RPA was associated with significantly increased risk for women reporting above median (>540) MET-min/week (OR = 1.51; 95% CI: 1.03, 2.23). Predominantly strenuous intensity RPA was nonsignificantly associated with lower IEOC risk for women reporting above median (>1800) MET-min/week (OR = 0.72; 95% CI: 0.33, 1.57). The inverse associations for mild and strenuous intensity RPA were most pronounced in obese women (body mass index >30 kg/m(2) ). The findings that mild and strenuous RPA may reduce the risk of IEOC particularly among obese women are difficult to reconcile with the increased risk observed for moderate RPA. Further research is warranted to determine whether these findings are genuine and, if so, their mechanistic basis.
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Abbott
authors.affiliation: Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
authors.forename: Elisa V
authors.initials: EV
authors.lastname: Bandera
authors.affiliation: Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
authors.forename: Bo
authors.initials: B
authors.lastname: Qin
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
authors.forename: Lauren C
authors.initials: LC
authors.lastname: Peres
authors.affiliation: Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina.
authors.forename: Patricia G
authors.initials: PG
authors.lastname: Moorman
authors.affiliation: Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: Jill
authors.initials: J
authors.lastname: Barnholtz-Sloan
authors.affiliation: Department of Oncology and the Karmanos Cancer Institute Population Studies and Disparities Research Program, Wayne State University, Detroit, Michigan.
authors.forename: Ann G
authors.initials: AG
authors.lastname: Schwartz
authors.affiliation: Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Ellen
authors.initials: E
authors.lastname: Funkhouser
authors.affiliation: Epidemiology Program, Louisiana State University Health Sciences Center School of Public Health, New Orleans, Los Angeles.
authors.forename: Edward S
authors.initials: ES
authors.lastname: Peters
authors.affiliation: Department of Oncology and the Karmanos Cancer Institute Population Studies and Disparities Research Program, Wayne State University, Detroit, Michigan.
authors.forename: Michele L
authors.initials: ML
authors.lastname: Cote
authors.affiliation: Hollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Alberg
authors.affiliation: Department of Medicine, University of Tennessee Medical Center-Knoxville, Knoxville, Tennessee.
authors.forename: Paul
authors.initials: P
authors.lastname: Terry
authors.affiliation: Cancer Prevention and Population Sciences Program, Baylor College of Medicine, Houston, Texas.
authors.forename: Melissa
authors.initials: M
authors.lastname: Bondy
authors.affiliation: Cancer Research Program, New Jersey State Cancer Registry, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Paddock
authors.affiliation: Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina.
authors.forename: Sydnee
authors.initials: S
authors.lastname: Crankshaw
authors.affiliation: Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.
authors.forename: Frances
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
authors.forename: Fabian
authors.initials: F
authors.lastname: Camacho
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
authors.forename: Joellen M
authors.initials: JM
authors.lastname: Schildkraut
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000453:epidemiology*; D011159:Population Surveillance; D011998:Recreation; D012306:Risk; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: African American; ovarian cancer; physical activity