title: Chronic Non-infectious Uveitis in Patients with Juvenile Idiopathic Arthritis.
abstract: OBJECTIVE
  To describe clinical findings and analyze treatment evolution of chronic, non-infectious uveitis in patients with juvenile idiopathic arthritis (JIA).
  
  
  METHODS
  A total of 82 patients (147 eyes) with JIA-related uveitis treated for ≥2 months were included (78% females; 79% bilateral uveitis; 74% anterior uveitis). Outcome measures were visual acuity (VA), inflammation control, side-effects, and surgical procedures.
  
  
  RESULTS
  Mean ± SD age at diagnosis was 4.9 ± 3.8 years; mean ± SD follow-up time was 8.7 ± 7.8 years. Mean VA did not significantly change throughout the study. Three (2%) eyes resulted in no light perception (NLP) vision. Thirty (37%) patients underwent 69 procedures. In total, 41 (50%) patients achieved inflammation control. TNF-α inhibitors were significantly associated with inflammation control. Seven (8.5%) patients stopped treatment due to side-effects.
  
  
  CONCLUSIONS
  JIA is a cause of significant ocular morbidity. TNF-α inhibitor use was associated with inflammation control. Prospective, randomized, double blind clinical trials in this regard are warranted.
authors.affiliation: a Department of Ophthalmology , University of Pittsburgh Medical Center , Pittsburgh , Pennsylvania , USA.
authors.forename: Anton M
authors.initials: AM
authors.lastname: Kolomeyer
authors.affiliation: b Institute of Ophthalmology and Visual Science , Rutgers University , Newark , New Jersey , USA.
authors.forename: Yufei
authors.initials: Y
authors.lastname: Tu
authors.affiliation: c Department of Ophthalmology and Visual Sciences, Scientific Institute San Raffaele , University Vita-Salute , Milan , Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Miserocchi
authors.affiliation: d Department of Quantitative Methods , Rutgers University , Newark , New Jersey , USA.
authors.forename: Mangala
authors.initials: M
authors.lastname: Ranjan
authors.affiliation: d Department of Quantitative Methods , Rutgers University , Newark , New Jersey , USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Davidow
authors.affiliation: b Institute of Ophthalmology and Visual Science , Rutgers University , Newark , New Jersey , USA.|e Metropolitan Eye Research and Surgery Institute , Palisades Park, New Jersey , USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Chu
mesh_terms: D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D012189:Retrospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha; D008727:Methotrexate
keywords: Immunomodulation; inflammation; juvenile idiopathic arthritis; uveitis