title: Colorimetric detection of sodium ion in serum based on the G-quadruplex conformation related DNAzyme activity.
abstract: There has been a big challenge in developing the Na(+) sensor that can be practically used in the physiological system with the interference of large amounts of K(+). In this research, a novel Na(+) sensor has been designed based on the G-quadruplex-conformation related DNAzyme activity. The sensor exhibits high selectivity and sensitivity with the detection limit of 0.6 μM, which enables the sensor to be practically used in determination of the Na(+) level in serum. The research not only provides a simple Na(+) sensor but also opens a new way for developing the detection technology of Na(+).
authors.affiliation: National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China. Electronic address: hongxsun@iccas.ac.cn.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Sun
authors.affiliation: National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China; College of Chemistry Engineering, North China University of Science and Technology, Tangshan, 063009, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Chen
authors.affiliation: College of Chemistry Engineering, North China University of Science and Technology, Tangshan, 063009, China.
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Zhang
authors.affiliation: National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China. Electronic address: ajguan@iccas.ac.cn.
authors.forename: Aijiao
authors.initials: A
authors.lastname: Guan
authors.affiliation: National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Qianfan
authors.initials: Q
authors.lastname: Yang
authors.affiliation: National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China; Graduate University of the Chinese Academy of Sciences, Yuquan Road 19(A), Shijingshan District, Beijing 100049, PR China.
authors.forename: Yunhua
authors.initials: Y
authors.lastname: Shi
authors.affiliation: National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China; Graduate University of the Chinese Academy of Sciences, Yuquan Road 19(A), Shijingshan District, Beijing 100049, PR China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Xu
authors.affiliation: National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China. Electronic address: tangyl@iccas.ac.cn.
authors.forename: Yalin
authors.initials: Y
authors.lastname: Tang
mesh_terms: D002942:Circular Dichroism; D003124:Colorimetry / Q000379:methods*; D021881:DNA, Catalytic / Q000378:metabolism*; D054856:G-Quadruplexes; D057230:Limit of Detection; D009690:Nucleic Acid Conformation; D012964:Sodium / Q000097:blood*
chemical_list: D021881:DNA, Catalytic; D012964:Sodium
keywords: Colorimetric; G-quadruplex DNAzyme; Na(+) detection; Serum