title: Relationship between the IL12B (rs3212227) gene polymorphism and susceptibility to multiple autoimmune diseases: A meta-analysis.
abstract: OBJECTIVE
  The purpose of this study was to evaluate whether a single-nucleotide polymorphism (SNP) IL12B 3(')UTR +1188A/C (rs3212227) confers susceptibility to several autoimmune diseases.
  
  
  METHODS
  A systematic literature search was conducted to identify relevant studies. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to estimate the strength of association.
  
  
  RESULTS
  Twenty-five studies were included in the meta-analysis, which contained 9794 cases and 11,330 controls. Our result indicated that IL12B +1188A/C (rs3212227) polymorphism was associated with type-1 diabetes (T1D) in the dominant model (p = 0.008), and an increased risk was found in East Asians in the dominant model (p < 0.001). East Asians rheumatoid arthritis (RA) patients seemed to be at risk of allelic model (p = 0.011). As to Behcet's disease (BD), there was a risk in dominant model (p = 0.020) and positive associations of dominant model, allelic model in East Asians (p = 0.009; p < 0.001, respectively). But we failed to find any association between IL12B +1188A/C (rs3212227) polymorphism with Graves' disease (GD) and ankylosing spondylitis (AS).
  
  
  CONCLUSIONS
  The present study suggests that the IL12B +1188A/C (rs3212227) polymorphism might be associated with genetic susceptibility to autoimmune diseases, such as T1D, RA, BD, but not GD and AS.
authors.affiliation: a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , P.R. China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , P.R. China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , P.R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , P.R. China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , P.R. China.
authors.forename: Jie-Bing
authors.initials: JB
authors.lastname: Wang
authors.affiliation: a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , P.R. China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , P.R. China.
authors.forename: Shuang-Shuang
authors.initials: SS
authors.lastname: Chen
authors.affiliation: a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , P.R. China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , P.R. China.
authors.forename: Tian-Ping
authors.initials: TP
authors.lastname: Zhang
authors.affiliation: a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , P.R. China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , P.R. China.
authors.forename: Si
authors.initials: S
authors.lastname: Li
authors.affiliation: a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , P.R. China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , P.R. China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.affiliation: a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , P.R. China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , P.R. China.
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D001327:Autoimmune Diseases / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D053762:Interleukin-12 Subunit p40 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D053762:Interleukin-12 Subunit p40
keywords: Autoimmune diseases; IL12B; Meta-analysis; Polymorphism