title: Functional neuroanatomy associated with the interaction between emotion and cognition in explicit memory tasks in patients with generalized anxiety disorder.
abstract: BACKGROUND
  The functional neuroanatomy for explicit memory in conjunction with the major anxiety symptoms in patients with generalized anxiety disorder (GAD) has not yet been clearly identified.
  
  
  OBJECTIVE
  To investigate the brain activation patterns on the interaction between emotional and cognitive function during the explicit memory tasks, as well as its correlation with clinical characteristics in GAD.
  
  
  METHODS
  The participants comprised GAD patients and age-matched healthy controls. The fMR images were obtained while the participants performed an explicit memory task with neutral and anxiety-inducing words.
  
  
  RESULTS
  Patients showed significantly decreased functional activities in the putamen, head of the caudate nucleus, hippocampus, and middle cingulate gyrus during the memory tasks with the neutral and anxiety-inducing words, whereas the precentral gyrus and ventrolateral prefrontal cortex were significantly increased only in the memory tasks with the anxiety-inducing words. Also, the blood oxygenation level-dependent (BOLD) signal changes in the hippocampus were positively correlated with the recognition accuracy for both neutral and anxiety-inducing words.
  
  
  CONCLUSIONS
  This study identified the brain areas associated with the interaction between emotional regulation and cognitive function in the explicit memory tasks in patients with GAD. These findings would be helpful to understand the neural mechanism on the explicit memory-related cognitive deficits and emotional dysfunction with GAD symptoms.
authors.affiliation: Research Institute for Medical Imaging, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Chung-Man
authors.initials: CM
authors.lastname: Moon
authors.affiliation: Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Republic of Korea.|Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea.
authors.forename: Jong-Chul
authors.initials: JC
authors.lastname: Yang
authors.affiliation: Research Institute for Medical Imaging, Chonnam National University Medical School, Gwangju, Republic of Korea gwjeong@jnu.ac.kr.|Department of Radiology, Chonnam National University Hospital, Chonnam Natioanl University Medical School, Gwangju, Republic of Korea.
authors.forename: Gwang-Woo
authors.initials: GW
authors.lastname: Jeong
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D003071:Cognition; D004644:Emotions; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Generalized anxiety disorder (GAD); explicit memory; functional magnetic resonance imaging (fMRI)