title: Daptomycin for Children in Clinical Practice Experience.
abstract: Data on daptomycin use in the pediatric setting are scanty. We conducted a multicenter, retrospective study on 46 children treated with intravenous daptomycin at a mean dosage of 7.0 mg/kg/d, for a median of 14 days. Three children had adverse events possibly related to daptomycin. The drug was overall well tolerated, even with prolonged treatment.
authors.affiliation: From the *Department of Paediatrics, University of Turin, AOU Città della Salute e della Scienza di Torino, Turin, Italy; †Infectious Diseases Unit and Laboratory of Microbiology (RB), Istituto Giannina Gaslini, Genoa, Italy; ‡Malattie Infettive Pediatriche, Ospedale dei Bambini "G.Di Cristina"-A.R.N.A.S. Palermo, Palermo, Italy; §Department of Sciences for Health promotion and Mother and Child Care "Giuseppe D'Alessandro," University of Palermo, Palermo, Italy; ¶Department of Paediatric Medicine, Paediatric and Infectious Diseases Unit, Children Hospital Bambino Gesù, IRCCS, Rome, Italy; ‖Department of Paediatrics, Azienda Ospedaliero-Universitaria "Santa Maria della Misericordia," Udine, Italy; **Paediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; ††University Department of Paediatrics, Unit of Immune and Infections Disease, Bambino Gesu' Children's Hospital, Rome Italy; and ‡‡Department of Sciences for Woman and Child's Health, University of Florence, Anna Meyer Children's University Hospital, Florence, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Garazzino
authors.forename: Elio
authors.initials: E
authors.lastname: Castagnola
authors.forename: Maria
authors.initials: M
authors.lastname: Di Gangi
authors.forename: Rita
authors.initials: R
authors.lastname: Ortolano
authors.forename: Andrzej
authors.initials: A
authors.lastname: Krzysztofiak
authors.forename: Agostino
authors.initials: A
authors.lastname: Nocerino
authors.forename: Susanna
authors.initials: S
authors.lastname: Esposito
authors.forename: Patrizia
authors.initials: P
authors.lastname: D'Argenio
authors.forename: Luisa
authors.initials: L
authors.lastname: Galli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Losurdo
authors.forename: Carmelina
authors.initials: C
authors.lastname: Calitri
authors.forename: Pier-Angelo
authors.initials: PA
authors.lastname: Tovo
mesh_terms: D061605:Administration, Intravenous; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001424:Bacterial Infections / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D017576:Daptomycin / Q000008:administration & dosage* / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin