title: A holey pursuit: lumen formation in the developing kidney.
abstract: The formation of polarized epithelial tubules is a hallmark of kidney development. One of the fundamental principles in tubulogenesis is that epithelia coordinate the polarity of individual cells with the surrounding cells and matrix. A central feature in this process is the segregation of membranes into spatially and functionally distinct apical and basolateral domains, and the generation of a luminal space at the apical surface. This review examines our current understanding of the cellular and molecular mechanisms that underlie the establishment of apical-basal polarity and lumen formation in developing renal epithelia, including the roles of cell-cell and cell-matrix interactions and polarity complexes. We highlight growing evidence from animal models, and correlate these findings with models of tubulogenesis from other organ systems, and from in vitro studies.
authors.affiliation: Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-8856, USA. denise.marciano@utsouthwestern.edu.
authors.forename: Denise K
authors.initials: DK
authors.lastname: Marciano
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000254:growth & development*; D007684:Kidney Tubules / Q000166:cytology / Q000254:growth & development*; D009024:Morphogenesis; D038081:Organogenesis
keywords: Afadin; Apical–basal polarity; Cadherin; Cap mesenchyme; Kidney development; Lumen; Nephron; Renal vesicle; Tubulogenesis