title: Kinetics of Circulating Plasma Cell-Free DNA in Paediatric Classical Hodgkin Lymphoma.
abstract: Levels of plasma cell-free DNA (cfDNA) of a large series of children with classical Hodgkin lymphoma (cHL) were evaluated and analyzed at diagnosis and during chemotherapy treatment in relation with clinical characteristics. CfDNA levels in cHL patients were significantly higher compared with controls (p=0.002). CfDNA at diagnosis was correlated with presence of B symptoms (p=0.027) and high erythrocyte sedimentation rate (p=0.049). We found that the increasing of plasma cfDNA after first chemotherapy cycle seems to be associated with a worse prognosis (p=0.049). Levels of plasma cfDNA might constitute an interesting non-invasive tool in cHL patients' management.
authors.affiliation: 1. Clinica di Oncoematologia Pediatrica, Dipartimento Salute della Donna e del Bambino, Azienda Ospedaliera-Universita' di Padova, Padova;
authors.forename: Simona
authors.initials: S
authors.lastname: Primerano
authors.affiliation: 2. Unita' di Oncoematologia, Azienda Ospedaliero-Universitaria di Ferrara S.Anna, Ferrara;
authors.forename: Roberta
authors.initials: R
authors.lastname: Burnelli
authors.affiliation: 1. Clinica di Oncoematologia Pediatrica, Dipartimento Salute della Donna e del Bambino, Azienda Ospedaliera-Universita' di Padova, Padova;
authors.forename: Elisa
authors.initials: E
authors.lastname: Carraro
authors.affiliation: 1. Clinica di Oncoematologia Pediatrica, Dipartimento Salute della Donna e del Bambino, Azienda Ospedaliera-Universita' di Padova, Padova;
authors.forename: Marta
authors.initials: M
authors.lastname: Pillon
authors.affiliation: 3. SOS di Radioterapia Pediatrica CRO Aviano;
authors.forename: Caterina
authors.initials: C
authors.lastname: Elia
authors.affiliation: 4. Dipartimento di Oncologia, Unita' di Oncoematologia Pediatrica, A.R.N.A.S. Ospedali Civico di Cristina e Benfratelli, Palermo;
authors.forename: Piero
authors.initials: P
authors.lastname: Farruggia
authors.affiliation: 5. Clinica Pediatrica, Università di Milano-Bicocca, Ospedale S.Gerardo, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Monza;
authors.forename: Alessandra
authors.initials: A
authors.lastname: Sala
authors.affiliation: 6. Dipartimento di Oncoematologia Pediatrica, Ospedale Bambino Gesu', Roma;
authors.forename: Luciana
authors.initials: L
authors.lastname: Vinti
authors.affiliation: 7. Dipartimento di Oncologia Pediatrica, Ospedale Santobono-Pausillipon, Napoli;
authors.forename: Salvatore
authors.initials: S
authors.lastname: Buffardi
authors.affiliation: 1. Clinica di Oncoematologia Pediatrica, Dipartimento Salute della Donna e del Bambino, Azienda Ospedaliera-Universita' di Padova, Padova;
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Basso
authors.affiliation: 3. SOS di Radioterapia Pediatrica CRO Aviano;
authors.forename: Maurizio
authors.initials: M
authors.lastname: Mascarin
authors.affiliation: 1. Clinica di Oncoematologia Pediatrica, Dipartimento Salute della Donna e del Bambino, Azienda Ospedaliera-Universita' di Padova, Padova;; 8. Istituto di Ricerca Pediatrica-Fondazione Città della Speranza, Padova.
authors.forename: Lara
authors.initials: L
authors.lastname: Mussolin
keywords: cell-free DNA; childhood.; classical Hodgkin Lymphoma