title: Usefulness of MR elastography for detecting clinical progression of cirrhosis from child-pugh class A to B in patients with type C viral hepatitis.
abstract: To evaluate the usefulness of magnetic resonance elastography (MRE) in detecting the clinical progression of cirrhosis from Child-Pugh class A to B in patients with hepatitis C.
  
  
  
  We reviewed the data of 101 consecutive patients with type C viral hepatitis and clinically suspected cirrhosis who fulfilled the all following criteria: available MRE at 1.5 Tesla (T) or 3.0T and laboratory tests within a month, Child-Pugh class A, platelet count less than 155 × 10(3) /μL, no clinical history of hepatocellular carcinoma, and ≥6 months of follow-up after MRE. We longitudinally analyzed the incidence of cirrhosis progression as defined by the clinical progression from Child-Pugh class A to B at two subsequent follow-up points. Risk of cirrhosis progression was assessed by Cox analyses and Kaplan-Meyer methods.
  
  
  
  Cirrhosis progression was noted in 25 patients during the follow-up period. Liver stiffness (hazard ratio [HR] by 1 kPa increase = 1.397; P = 0.0074), Child-Pugh score of 6 versus score 5 (HR of 3.085; P = 0.0276), and treatment responses to anti-viral therapy versus nonresponse (HR of <0.001, P = 0.0006) were independent risk factors of cirrhosis progression. The 1-year risk (0.7%; 95% confidence interval, 0.1-4.2%) of cirrhosis progression was negligible in patients with liver stiffness of <3.3 kPa or response to anti-viral treatment.
  
  
  
  MRE is useful to stratify the risk of cirrhosis progression in patients with hepatitis C. J. Magn. Reson. Imaging 2016;44:715-722.
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Takamura
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Utaroh
authors.initials: U
authors.lastname: Motosugi
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Ichikawa
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Sano
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Morisaka
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ichikawa
authors.affiliation: First Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Enomoto
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Onishi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006526:Hepatitis C / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
keywords: cirrhosis; elastography; magnetic resonance imaging; prognosis; type C hepatitis