title: Congenital fibrosarcoma in complete remission with Somatostatin, Bromocriptine, Retinoids, Vitamin D3, Vitamin E, Vitamin C, Melatonin, Calcium, Chondroitin sulfate associated with low doses of Cyclophosphamide in a 14-year Follow up.
abstract: At birth, a male child presented a 6 cm tumour in the right leg. The tumour was partially removed after just 12 days. Histology showed a congenital fibrosarcoma associated with reactive lymphadenitis. A first cycle of adjuvant chemotherapy did not prevent the rapid progression of the disease. Subsequent evaluation for surgical removal raised serious concerns due to the need for a major operation involving total amputation of the right leg and hemipelvectomy. Since surgery could not exclude the possibility of disease recurrence and since the traditional cycles of chemotherapy did not offer any possibility of a cure, the parents opted for the Di Bella Method. The combined use of Somatostatin, Melatonin, Retinoids solubilized in Vit. E, Vit. C, Vit. D3, Calcium, and Chondroitin sulfate associated with low doses of Cyclophosphamide resulted in a complete objective response, still present 14 years later, with no toxicity and without the need for hospitalization, allowing a normal quality of life and perfectly normal adolescent psycho-physical development.
authors.affiliation: Di Bella Foundation, Bologna, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Bella
authors.affiliation: Di Bella Foundation, Bologna, Italy.
authors.forename: Rosilde
authors.initials: R
authors.lastname: Toscano
authors.affiliation: Di Bella Foundation, Bologna, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ricchi
authors.affiliation: Rizzoli Scientific Research and Care Institute, Via Giulio Cesare Pupill, 40136 Bologna, Italy.
authors.forename: Biagio
authors.initials: B
authors.lastname: Colori
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000008:administration & dosage; D001971:Bromocriptine / Q000008:administration & dosage; D002118:Calcium / Q000008:administration & dosage; D002762:Cholecalciferol / Q000008:administration & dosage; D002809:Chondroitin Sulfates / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D005354:Fibrosarcoma / Q000151:congenital / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007866:Leg; D060046:Maintenance Chemotherapy; D008297:Male; D008550:Melatonin / Q000008:administration & dosage; D012074:Remission Induction; D012176:Retinoids / Q000008:administration & dosage; D012983:Soft Tissue Neoplasms / Q000151:congenital / Q000188:drug therapy*; D013004:Somatostatin / Q000008:administration & dosage; D014810:Vitamin E / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D012176:Retinoids; D014815:Vitamins; D014810:Vitamin E; D002762:Cholecalciferol; D001971:Bromocriptine; D013004:Somatostatin; D003520:Cyclophosphamide; D002809:Chondroitin Sulfates; D008550:Melatonin; D001205:Ascorbic Acid; D002118:Calcium