title: Renal Ischemia/Reperfusion Injury in Diabetic Rats: The Role of Local Ischemic Preconditioning.
abstract: BACKGROUND
  The aim of this study was to evaluate the effects of local ischemic preconditioning using biochemical markers and histopathologically in the diabetic rat renal IR injury model.
  
  
  METHODS
  DM was induced using streptozotocin. Rats were divided into four groups: Group I, nondiabetic sham group (n = 7), Group II, diabetic sham group (n = 6), Group III, diabetic IR group (diabetic IR group, n = 6), and Group IV, diabetic IR + local ischemic preconditioning group (diabetic IR + LIPC group, n = 6). Ischemic renal injury was induced by clamping the bilateral renal artery for 45 min. 4 h following ischemia, clearance protocols were applied to assess biochemical markers and histopathologically in rat kidneys.
  
  
  RESULTS
  The histomorphologic total cell injury scores of the nondiabetic sham group were significantly lower than diabetic sham, diabetic IR, and diabetic IR + LIPC groups. Diabetic IR group scores were not significantly different than the diabetic sham group. But diabetic IR + LIPC group scores were significantly higher than the diabetic sham and diabetic IR groups.
  
  
  CONCLUSIONS
  Local ischemic preconditioning does not reduce the risk of renal injury induced by ischemia/reperfusion in diabetic rat model.
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Ozbilgin
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Sevda
authors.initials: S
authors.lastname: Ozkardesler
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Mert
authors.initials: M
authors.lastname: Akan
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Nilay
authors.initials: N
authors.lastname: Boztas
authors.affiliation: Department of General Surgery, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Mucahit
authors.initials: M
authors.lastname: Ozbilgin
authors.affiliation: Department of Histology and Embryology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Bekir Ugur
authors.initials: BU
authors.lastname: Ergur
authors.affiliation: Department of General Surgery, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Serhan
authors.initials: S
authors.lastname: Derici
authors.affiliation: Department of Experienced Laboratory Animal Science, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Mehmet Ensari
authors.initials: ME
authors.lastname: Guneli
authors.affiliation: Department of Nutrition and Dietetics, Izmir Ataturk School of Health, Ege University, Izmir, Turkey.
authors.forename: Reci
authors.initials: R
authors.lastname: Meseri
mesh_terms: D058186:Acute Kidney Injury / Q000503:physiopathology / Q000628:therapy*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D019194:Ischemic Preconditioning; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D008099:Liver / Q000503:physiopathology; D051381:Rats; D015427:Reperfusion Injury / Q000503:physiopathology / Q000628:therapy*