title: The Immunology of CD1- and MR1-Restricted T Cells.
abstract: CD1- and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic antigens, such as lipids and small metabolites, and account for a major fraction of circulating and tissue-resident T cells. They represent a readily activated, long-lasting population of effector cells and contribute to the early phases of immune response, orchestrating the function of other cells. This review addresses the main aspects of their immunological functions, including antigen and T cell receptor repertoires, mechanisms of nonpeptidic antigen presentation, and the current evidence for their participation in human and experimental diseases.
authors.affiliation: Department of Biomedicine, Basel University Hospital and Basel University, CH-4031 Basel, Switzerland; email: lucia.mori@unibas.ch , marco.lepore@unibas.ch , gennaro.delibero@unibas.ch.|Singapore Immunology Network, A*STAR, 138648 Singapore.
authors.forename: Lucia
authors.initials: L
authors.lastname: Mori
authors.affiliation: Department of Biomedicine, Basel University Hospital and Basel University, CH-4031 Basel, Switzerland; email: lucia.mori@unibas.ch , marco.lepore@unibas.ch , gennaro.delibero@unibas.ch.
authors.forename: Marco
authors.initials: M
authors.lastname: Lepore
authors.affiliation: Department of Biomedicine, Basel University Hospital and Basel University, CH-4031 Basel, Switzerland; email: lucia.mori@unibas.ch , marco.lepore@unibas.ch , gennaro.delibero@unibas.ch.|Singapore Immunology Network, A*STAR, 138648 Singapore.
authors.forename: Gennaro
authors.initials: G
authors.lastname: De Libero
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000941:Antigens / Q000276:immunology; D018949:Antigens, CD1 / Q000378:metabolism; D001327:Autoimmune Diseases / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D007157:Immunologic Surveillance; D007239:Infections / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D015778:Minor Histocompatibility Antigens / Q000378:metabolism; D055611:Natural Killer T-Cells / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology*; D011485:Protein Binding; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000378:metabolism*
chemical_list: D000941:Antigens; D018949:Antigens, CD1; D015395:Histocompatibility Antigens Class I; C094840:MR1 protein, human; D015778:Minor Histocompatibility Antigens; D011948:Receptors, Antigen, T-Cell
keywords: T cell receptor; antigen presentation; autoimmune diseases; infectious diseases; innate-like T cells; lipid antigens; metabolite antigens; mucosal-associated invariant T cells; natural killer T cells; tumor immunity