title: Synthesis and an angiolytic role of novel piperazine-benzothiazole analogues on neovascularization, a chief tumoral parameter in neoplastic development.
abstract: A novel series of benzoic acid N'-[2-(4-benzothiazol-2-yl-piperazin-1-yl)-acetyl]-hydrazides 6a-j were synthesized and characterized by IR, (1)H, (13)C NMR, elemental and mass spectral analyses. The in-vitro cytotoxicity and cell viability assay of the synthesized compounds 6a-j were evaluated against Dalton's lymphoma ascites (DLA) cells. Our results showed that compound 6c with a bromo group on phenyl ring has showed promising antiproliferative efficacy. Further investigation of compound 6c on in-vivo treatment model depicts the increased tumor suppression through inhibition of angiogenesis.
authors.affiliation: Department of Chemistry, Yuvaraja's College, University of Mysore, Karnataka, India.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Al-Ghorbani
authors.affiliation: Molecular Biomedicine Laboratory, Postgraduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Karnataka, India.
authors.forename: G S
authors.initials: GS
authors.lastname: Pavankumar
authors.affiliation: Department of Chemistry, Yuvaraja's College, University of Mysore, Karnataka, India.
authors.forename: P
authors.initials: P
authors.lastname: Naveen
authors.affiliation: Molecular Biomedicine Laboratory, Postgraduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Karnataka, India.
authors.forename: Prabhu
authors.initials: P
authors.lastname: Thirusangu
authors.affiliation: Molecular Biomedicine Laboratory, Postgraduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Karnataka, India.
authors.forename: B T
authors.initials: BT
authors.lastname: Prabhakar
authors.affiliation: Department of Chemistry, Yuvaraja's College, University of Mysore, Karnataka, India. Electronic address: shaukathara@yahoo.co.in.
authors.forename: Shaukath Ara
authors.initials: SA
authors.lastname: Khanum
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008223:Lymphoma / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000473:pathology; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006834:Hydrazines; C000612182:N'-(2-(4-benzothiazol-2-yl-piperazin-1-yl)-acetyl)-hydrazide; D010879:Piperazines
keywords: Angiogenesis; Antiproliferative; DLA cells; Piperazine–benzothiazole