title: Solid-Supported Lipid Multilayers under High Hydrostatic Pressure.
abstract: In this work, the structure of solid-supported lipid multilayers exposed to increased hydrostatic pressure was studied in situ by X-ray reflectometry at the solid-liquid interface between silicon and an aqueous buffer solution. The layers' vertical structure was analyzed up to a maximum pressure of 4500 bar. The multilayers showed phase transitions from the fluid into different gel phases. With increasing pressure, a gradual filling of the sublayers between the hydrophilic head groups with water was observed. This process was inverted when the pressure was decreased, yielding finally smaller water layers than those in the initial state. As is commonly known, water has an abrasive effect on lipid multilayers by the formation of vesicles. We show that increasing pressure can reverse this process so that a controlled switching between multi- and bilayers is possible.
authors.affiliation: Fakultät Physik/DELTA, TU Dortmund , 44221 Dortmund, Germany.
authors.forename: Benedikt
authors.initials: B
authors.lastname: Nowak
authors.affiliation: Fakultät Physik/DELTA, TU Dortmund , 44221 Dortmund, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Paulus
authors.affiliation: Fakultät Physik/DELTA, TU Dortmund , 44221 Dortmund, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Nase
authors.affiliation: Fakultät Physik/DELTA, TU Dortmund , 44221 Dortmund, Germany.
authors.forename: Paul
authors.initials: P
authors.lastname: Salmen
authors.affiliation: Physikalische Chemie II, TU Dortmund , 44221 Dortmund, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Degen
authors.affiliation: Fakultät Physik/DELTA, TU Dortmund , 44221 Dortmund, Germany.
authors.forename: Florian J
authors.initials: FJ
authors.lastname: Wirkert
authors.affiliation: European Synchrotron Radiation Facility , F-38043 Grenoble, France.
authors.forename: Veijo
authors.initials: V
authors.lastname: Honkimäki
authors.affiliation: Fakultät Physik/DELTA, TU Dortmund , 44221 Dortmund, Germany.
authors.forename: Metin
authors.initials: M
authors.lastname: Tolan
mesh_terms: D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D006874:Hydrostatic Pressure; D008051:Lipid Bilayers / Q000737:chemistry*; D044367:Phase Transition; D012825:Silicon; D014867:Water / Q000737:chemistry
chemical_list: D008051:Lipid Bilayers; D014867:Water; D004134:Dimyristoylphosphatidylcholine; D012825:Silicon