title: Effect of hypothyroidism on female reproductive hormones.
abstract: OBJECTIVE
  Objective was to evaluate reproductive hormones levels in hypothyroid women and impact of treatment on their levels.
  
  
  METHODS
  A total of 59 women with untreated primary hypothyroidism were included in this prospective study. Venous blood was taken at baseline and after euthyroidism was achieved for measuring serum free thyroxine, free triiodothyronine (FT3), thyroid stimulating hormone (TSH), prolactin (PRL), follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), and thyroid peroxidase antibody. Thirty-nine healthy women with regular menstrual cycles without any hormonal disturbances served as controls. The statistical analysis was performed using the Statistical Package for the Social Sciences Version 20 ([SPSS] IBM Corporation, Armonk, NY, USA). P < 0.05 was considered statistically significant.
  
  
  RESULTS
  On an average at diagnosis cases have more serum TSH (mean [M] = 77.85; standard error [SE] = 11.72), PRL (M = 39.65; SE = 4.13) and less serum E2 (M = 50.00; SE = 2.25) and T (M = 35.40; SE = 2.31) than after achieving euthyroidism (M = 1.74; SE = 0.73), (M = 16.04; SE = 0.84), (M = 76.25; SE = 2.60), and (M = 40.29; SE = 2.27), respectively. This difference was statistically significant t (58) = 6.48, P <0.05; t (58) = 6.49, P < 0.05; t (58) = 12.47; P < 0.05; and t (58) = 2.04, P < 0.05; respectively. Although average serum FSH (M = 12.14; SE = 0.40) and LH (M = 5.89; SE = 0.27) were lower in cases at diagnosis than after achieving euthyroidism (M = 12.70; SE = 0.40), (M = 6.22; SE = 0.25), respectively, but these differences were statistically insignificant t (58) = 1.61, P = 0.11; t (58) = 1.11, P = 0.27, respectively.
  
  
  CONCLUSIONS
  The study has demonstrated low E2 and T levels in hypothyroid women which were increased after achieving euthyroidism. Although average serum FSH and LH were increased in hypothyroid women after achieving euthyroidism but this difference was statistically insignificant.
authors.affiliation: Department of Endocrinology, LLRM Medical College, Meerut, Uttar Pradesh, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Saran
authors.affiliation: Department of Biochemistry, Subharti Medical College, Meerut, Uttar Pradesh, India.
authors.forename: Bharti Sona
authors.initials: BS
authors.lastname: Gupta
authors.affiliation: Department of Endocrinology, Pushpagiri Medical College, Thiruvalla, Kerala, India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Philip
authors.affiliation: Department of Medicine, King George Medical College, Lucknow, Uttar Pradesh, India.
authors.forename: Kumar Sanjeev
authors.initials: KS
authors.lastname: Singh
authors.affiliation: Department of Medicine, LLRM Medical College, Meerut, Uttar Pradesh, India.
authors.forename: Sureshrao Anoop
authors.initials: SA
authors.lastname: Bende
authors.affiliation: Department of Ophthalmology, LLRM Medical College, Meerut, Uttar Pradesh, India.
authors.forename: Puspalata
authors.initials: P
authors.lastname: Agroiya
authors.affiliation: Hormone Care and Research Centre, Ghaziabad, Uttar Pradesh, India.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Agrawal
keywords: Estradiol; follicular stimulating hormone; hypothyroidism