title: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Biomarkers of Primary Open-Angle Glaucoma.
abstract: We aimed to assess the levels of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with primary open-angle glaucoma (POAG) and to compare the NLR and PLR results of patients with POAG and ocular hypertension, as well as in healthy controls.
  
  
  
  Eighty-four patients with POAG, 94 patients with ocular hypertension, and 80 healthy subjects were enrolled in this retrospective study. Complete ophthalmological examination and complete blood count measurements were performed for all subjects.
  
  
  
  There was a significant difference in the NLR (P=0.003) and PLR (P=0.049) between POAG and control groups. In addition, there was a correlation between pattern standard deviation and NLR in the POAG group. The receiver operating characteristics analysis revealed that the value of NLR to distinguish patients with POAG and controls was found to be 0.651. The best cutoff value was 2.1, with a sensitivity of 65% and a specificity of 65%.
  
  
  
  Our study for the first time provides evidence that NLR and PLR may be useful as biomarkers in patients with POAG.
authors.affiliation: *Department of Ophthalmology, Van Military Hospital, Van †Department of Biochemistry, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul ‡Department of Ophthalmology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Ozgonul
authors.forename: Erdim
authors.initials: E
authors.lastname: Sertoglu
authors.forename: Tarkan
authors.initials: T
authors.lastname: Mumcuoglu
authors.forename: Murat
authors.initials: M
authors.lastname: Kucukevcilioglu
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000166:cytology*; D016022:Case-Control Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000097:blood*; D006801:Humans; D007429:Intraocular Pressure; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology*; D010976:Platelet Count; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers