title: The Optic Nerve Head in Primary Open-Angle Glaucoma Eyes With High Myopia: Characteristics and Association With Visual Field Defects.
abstract: To evaluate the morphologic characteristics of optic neuropathy and its association with visual field (VF) defects in primary open-angle glaucoma (POAG) eyes with high myopia.
  
  
  
  In this cross-sectional study, we reviewed data from 375 Taiwanese patients (375 eyes) of POAG, ages 20 to 60 years. Optic disc photographs were used for planimetric measurements of morphologic variables. The myopic refraction was divided into high myopia (<-6.0 D) and nonhigh myopia (moderate myopia to hyperopia). The optic disc area was classified as moderate (1.59 to 2.85 mm(2)), large, and small. Differences in characteristics between groups, correlations with the disc area, and factors associated with VF defects were determined.
  
  
  
  Of the 142 highly myopic eyes, 33 (23%) had a large disc, 26 (18%) had a small disc, and 55 (39%) had a tilted disc. Large discs had a higher cup-to-disc (C/D) area ratio and a higher tilt ratio; small discs had a smaller rim area and a lower tilt ratio (all P<0.05). Characteristics associated with high myopia included a smaller rim area, a higher C/D area ratio, and a lower tilt ratio (all P<0.001). In logistic regression, the refraction, the C/D area ratio, the rim area, and the tilt ratio (all P<0.05) were associated with VF defects.
  
  
  
  In Taiwanese individuals with POAG, our study found that tilted, large, or small discs were prevalent in highly myopic eyes. Of these characteristics, only the disc tilt and high myopia by itself were associated with the severity of glaucomatous optic neuropathy.
authors.affiliation: *Department of Ophthalmology, Yonghe Cardinal Tien Hospital ‡Department of Medicine, Mackay Medical College, New Taipei City †Department of Ophthalmology, MacKay Memorial Hospital §Mackay Junior College of Medicine, Nursing, and Management ∥Department of Ophthalmology, National Taiwan University ¶Taipei Medical University, Taipei, Taiwan.
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Chen
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Lan
authors.forename: Jui-Wen
authors.initials: JW
authors.lastname: Hsieh
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000150:complications* / Q000175:diagnosis; D012607:Scotoma / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult