title: Fas/FasL, Bcl2 and Caspase-8 gene polymorphisms in Chinese patients with rheumatoid arthritis.
abstract: Apoptosis signals are necessary for maintaining homeostasis and an adequate immune response. Dysregulation of apoptosis-related genes in the immune system has an important impact on autoimmune diseases such as rheumatoid arthritis (RA). Thus, we investigated the association between Fas rs2234767 G/A, FasL rs763110 C/T, Bcl2 rs12454712 T/C, Bcl2 rs17757541 C/G, and Caspase-8 rs1035142 G/T polymorphisms and RA susceptibility in a Chinese population. These five single-nucleotide polymorphisms (SNPs) were studied in a Chinese population consisting of 615 patients with RA and 839 controls. Genotyping was performed using a custom-by-design 48-Plex SNP scan TM kit. Furthermore, we undertook a meta-analysis between FasL rs763110 C/T and RA. This study indicated that Fas rs2234767 and Bcl2 rs17757541 polymorphisms were risk factors for RA. No association was observed between FasL rs763110 C/T, Bcl2 rs12454712 T/C, and Caspase-8 rs1035142 G/T polymorphisms and RA in this study. The results of this meta-analysis suggested no significant association between FasL rs763110 C/T and RA. However, stratification analysis of this meta-analysis indicated that FasL rs763110 C/T increased the risk of Caucasian RA patients. In conclusion, this study demonstrated that Fas rs2234767 G/A and Bcl2 rs17757541 T/C polymorphisms might be associated with an increased risk of RA. This meta-analysis revealed that FasL rs763110 C/T was associated with an increased risk of Caucasian RA patients.
authors.affiliation: Department of Orthopaedics, The Jintan Hospital Affiliated to Jiangsu University, Changzhou, 213200, China.
authors.forename: Aiping
authors.initials: A
authors.lastname: Zhu
authors.affiliation: Department of Orthopedic Trauma, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, 213003, China.
authors.forename: Mingjie
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Orthopedic Trauma, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, 213003, China.
authors.forename: Guoxin
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Department of Orthopedic Trauma, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, 213003, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Orthopedic Trauma, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, 213003, China. lrp216@sina.com.|Central Laboratory, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, 213003, China. lrp216@sina.com.
authors.forename: Ruiping
authors.initials: R
authors.lastname: Liu
authors.affiliation: Central Laboratory, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, 213003, China. doctor_wang1960@163.com.|Department of Cardiothoracic Surgery, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, 213003, China. doctor_wang1960@163.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D053181:Caspase 8 / Q000235:genetics*; D002681:China / Q000453:epidemiology; D053222:Fas Ligand Protein / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics; D019014:fas Receptor / Q000235:genetics*
chemical_list: C000595707:BCL2 protein, human; C491901:FAS protein, human; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D005819:Genetic Markers; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor; C505530:CASP8 protein, human; D053181:Caspase 8
keywords: B cell lymphoma 2; Caspase-8; Fas/FasL; Rheumatoid arthritis; Single-nucleotide polymorphism