title: The Many Faces of IpaB.
abstract: The type III secretion system (T3SS) is Shigella's most important virulence factor. The T3SS apparatus (T3SA) is comprised of an envelope-spanning basal body and an external needle topped by a tip complex protein called IpaD. This nanomachine is used to deliver effector proteins into host cells to promote pathogen entry. A key component of the matured T3SS needle tip complex is the translocator protein IpaB. IpaB can exist in multiple states when prepared as a recombinant protein, however, it has also been described as having additional roles in Shigella pathogenesis. This mini-review will briefly describe some of the features of IpaB as a T3SS needle tip protein, as a pore-forming translocator protein and as an effector protein. Reflection on the potential importance of the different in vitro states of IpaB on its function and importance in serotype-independent vaccines is also provided.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, University of Kansas Lawrence, KS, USA.
authors.forename: Wendy L
authors.initials: WL
authors.lastname: Picking
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, University of Kansas Lawrence, KS, USA.
authors.forename: William D
authors.initials: WD
authors.lastname: Picking
mesh_terms: D000942:Antigens, Bacterial / Q000378:metabolism; D017209:Apoptosis / Q000276:immunology; D001426:Bacterial Proteins / Q000378:metabolism*; D004405:Dysentery, Bacillary / Q000382:microbiology / Q000473:pathology*; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000382:microbiology*; D018832:Molecular Chaperones / Q000378:metabolism; D012760:Shigella / Q000472:pathogenicity*; D000069296:Type III Secretion Systems / Q000378:metabolism*; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C095770:IpaD protein, Shigella flexneri; D018832:Molecular Chaperones; D000069296:Type III Secretion Systems; D037521:Virulence Factors; C087447:ipaB protein, Shigella; C094580:IpgC protein, Shigella
keywords: IpaB; Shigella; invasion plasmid antigen; pathogenesis; type III secretion