title: Effects of Exenatide on Metabolic Changes, Sexual Hormones, Inflammatory Cytokines, Adipokines, and Weight Change in a DHEA-Treated Rat Model.
abstract: Insulin resistance and hyperandrogenism are the main features of polycystic ovarian syndrome (PCOS). Low-grade inflammation is also involved in PCOS. This study was performed to evaluate the effect of exenatide on metabolic changes, sexual hormones, inflammatory cytokines, adipokines, and weight changes in a dehydroepiandrosterone (DHEA)-treated rat model. After the model was produced by daily subcutaneous injections of DHEA, rats were given metformin (265 mg/kg), exenatide (10 μg/kg), and saline (1 mL). One group served as a control group. Blood samples and ovarian tissues were removed and prepared for biochemical and hormonal analyses. Exenatide significantly reduced body weight and insulin, testosterone, interleukin 6 (IL-6), PEDF, and visfatin levels. Exenatide also ameliorated changes in ovarian morphology, as evidenced by decreased numbers of cystic follicles and various follicles and elevated numbers of granular cell layers. The effects observed with exenatide were comparable to those observed with metformin. This study has provided evidence that exenatide may be efficient in the treatment of PCOS.
authors.affiliation: Department of Radiology, Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, China.
authors.forename: Lingjun
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Pharmacy, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Ji
authors.affiliation: Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Jin
authors.affiliation: Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Bi
authors.affiliation: Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China.
authors.forename: Wenhuan
authors.initials: W
authors.lastname: Feng
authors.affiliation: Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China shanmeishen@126.com zhudalong@nju.edu.cn.
authors.forename: Shanmei
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China shanmeishen@126.com zhudalong@nju.edu.cn.
authors.forename: Dalong
authors.initials: D
authors.lastname: Zhu
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism*; D003687:Dehydroepiandrosterone; D004195:Disease Models, Animal; D000077270:Exenatide; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism*; D008687:Metformin / Q000008:administration & dosage; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D010455:Peptides / Q000008:administration & dosage* / Q000627:therapeutic use; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D014688:Venoms / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D054392:Adipokines; D016207:Cytokines; D012739:Gonadal Steroid Hormones; D018836:Inflammation Mediators; D010455:Peptides; D014688:Venoms; D003687:Dehydroepiandrosterone; D008687:Metformin; D000077270:Exenatide
keywords: dehydroepiandrosterone; exenatide; low-grade inflammation; metformin; polycystic ovarian syndrome; rats