title: Electrochemical redox signaling of hemoglobin in human whole blood and its relevance to anemia and thalassemia diagnosis.
abstract: A highly redox active human whole blood-carbon nanomaterial modified electrode has been developed, which showed a redox peak (vs. Ag/AgCl) similar to that of hemoglobin (vs. Ag/AgCl) in red blood cells. Clinical relevance of this for direct electrochemical analysis of blood hemoglobin content (anemia) and thalassemia disease diagnosis was demonstrated.
authors.affiliation: Environmental and Analytical Chemistry Division, School of Advanced Sciences, Vellore Institute of Technology University, Vellore-632 014, India. askumarchem@yahoo.com.
authors.forename: Khairunnisa
authors.initials: K
authors.lastname: Amreen
authors.affiliation: Environmental and Analytical Chemistry Division, School of Advanced Sciences, Vellore Institute of Technology University, Vellore-632 014, India. askumarchem@yahoo.com.
authors.forename: Annamalai Senthil
authors.initials: AS
authors.lastname: Kumar
mesh_terms: D000328:Adult; D000740:Anemia / Q000097:blood* / Q000175:diagnosis*; D001774:Blood Chemical Analysis / Q000295:instrumentation / Q000379:methods*; D004563:Electrochemistry; D004566:Electrodes; D005260:Female; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007223:Infant; D008297:Male; D049329:Nanostructures / Q000737:chemistry; D010084:Oxidation-Reduction; D013789:Thalassemia / Q000097:blood* / Q000175:diagnosis*
chemical_list: D006454:Hemoglobins