title: [Treatment of drugs-associated non-hereditary angioedema mediated by bradykinin].
abstract: Angioedema is a deep intradermal or sub-cutaneous edema, which can be mediated by histamine, bradykinin or mixture of both components. The aims of this review are to describe the clinical approach and diagnosis of non-hereditary bradykinin-mediated angioedema induced by drugs such as: angiotensin-converting inhibitor, sartan, gliptins, rapamycin or some thrombolytic reagents and renin inhibitors. Furthermore, we will discuss the drug management of these angioedema, which is mainly based on C1 inhibitor concentrate or icatibant administration.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Muller
authors.forename: Thomas
authors.initials: T
authors.lastname: Harr
mesh_terms: D000799:Angioedema / Q000139:chemically induced* / Q000188:drug therapy; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000627:therapeutic use; D065094:Bradykinin B2 Receptor Antagonists / Q000627:therapeutic use; D050718:Complement C1 Inhibitor Protein / Q000627:therapeutic use*; D006801:Humans
chemical_list: D065094:Bradykinin B2 Receptor Antagonists; D050718:Complement C1 Inhibitor Protein; C065679:icatibant; D001920:Bradykinin