title: A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides.
abstract: Sodium azide is toxic and widely used in agricultural, commercial products, and research laboratories. Thus it is of a significant environmental concern and there is a need for the development of a rapid detection method. A fluorogenic dibenzylcyclooctyne derivative (Fl-DIBO) is herein described as a fluorescent probe for the rapid detection of inorganic azide via Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC). Fl-DIBO was found to be highly selective toward NaN3 in comparison to other common anions with good sensitivity and detection limit of 10μM.
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302-3965, USA.
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.affiliation: Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Friscourt
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302-3965, USA.
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Dai
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302-3965, USA.
authors.forename: Lifang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302-3965, USA.
authors.forename: Yueqin
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
authors.forename: Geert-Jan
authors.initials: GJ
authors.lastname: Boons
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302-3965, USA.
authors.forename: Siming
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302-3965, USA. Electronic address: wang@gsu.edu.
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001593:Benzyl Compounds / Q000737:chemistry*; D057930:Click Chemistry / Q000379:methods; D061565:Cycloaddition Reaction; D005456:Fluorescent Dyes / Q000737:chemistry*; D019810:Sodium Azide / Q000032:analysis*; D013050:Spectrometry, Fluorescence / Q000379:methods
chemical_list: D000480:Alkynes; D001593:Benzyl Compounds; D005456:Fluorescent Dyes; C042001:1-octyne; D019810:Sodium Azide
keywords: Click chemistry; Fluorescent detection; Quantitative analysis; Sodium azide