title: Kinetics genetics: Incorporating the concept of genomic balance into an understanding of quantitative traits.
abstract: While most mutations are recessive, variants that affect quantitative traits are largely semi-dominant in their action making hybrids between divergent genotypes intermediate. In parallel, changes in chromosomal dosage (aneuploidy) for multiple regions of the genome modulate quantitative characters. We have previously argued that these observations are a reflection of a common process, originating from the more or less subtle effects of changes in dosage on the action of multi-subunit regulatory machineries. Kinetic analyses that vary the amount of one subunit of a complex while holding others constant do not always predict a linear response for the production of the whole. Indeed, in many instances, strong non-linear effects are expected. Here, we advocate that these kinetic observations and predictions should be incorporated into quantitative genetics thought.
authors.affiliation: Division of Biological Sciences, University of Missouri, Columbia, MO 65211, United States. Electronic address: BirchlerJ@Missouri.edu.
authors.forename: James A
authors.initials: JA
authors.lastname: Birchler
authors.affiliation: Division of Biological Sciences, University of Missouri, Columbia, MO 65211, United States.
authors.forename: Adam F
authors.initials: AF
authors.lastname: Johnson
authors.affiliation: Institut Jacques Monod, 15 rue Helene Brion, 75013 Paris, France; Universite Paris Diderot, Paris, France.
authors.forename: Reiner A
authors.initials: RA
authors.lastname: Veitia
mesh_terms: D018745:Genome, Plant; D040582:Inheritance Patterns / Q000235:genetics; D007700:Kinetics; D008957:Models, Genetic; D010641:Phenotype; D019655:Quantitative Trait, Heritable
keywords: Additive inheritance; Dominance; Dosage effect; Epistasis; Gene balance hypothesis; Genetic load; Interactome; Inverse effect; Macromolecular complexes; Missing heritability; QTL; Quantitative genetics