title: Cytokines during periodontal wound healing: potential application for new therapeutic approach.
abstract: Regeneration of periodontal tissues is one of the main goals of periodontal therapy. However, current treatment, including surgical approach, use of membrane to allow maturation of all periodontal tissues, or use of enamel matrix derivatives, presents limitations in their indications and outcomes leading to the development of new tissue engineering strategies. Several cytokines are considered as key molecules during periodontal destruction process. However, their role during each phase of periodontal wound healing remains unclear. Control and modulation of the inflammatory response and especially, release of cytokines or activation/inhibition in a time- and spatial-controlled manner may be a potential perspective for periodontal tissue engineering. The aim of this review was to summarize the specific role of several cytokines during periodontal wound healing and the potential therapeutic interest of inflammatory modulation for periodontal regeneration especially related to the expression sequence of cytokines.
authors.affiliation: INSERM (French National Institute of Health and Medical Research), UMR 1109, Osteoarticular and Dental Regenerative Nanomedicine Laboratory, Faculté de Médecine de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.|Department of periodontology, Dental Faculty, University of Strasbourg, Strasbourg, France.
authors.forename: D N
authors.initials: DN
authors.lastname: Morand
authors.affiliation: INSERM (French National Institute of Health and Medical Research), UMR 1109, Osteoarticular and Dental Regenerative Nanomedicine Laboratory, Faculté de Médecine de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.|Department of periodontology, Dental Faculty, University of Strasbourg, Strasbourg, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Davideau
authors.affiliation: INSERM (French National Institute of Health and Medical Research), UMR 1109, Osteoarticular and Dental Regenerative Nanomedicine Laboratory, Faculté de Médecine de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.|Department of periodontology, Dental Faculty, University of Strasbourg, Strasbourg, France.
authors.forename: F
authors.initials: F
authors.lastname: Clauss
authors.affiliation: INSERM (French National Institute of Health and Medical Research), UMR 1109, Osteoarticular and Dental Regenerative Nanomedicine Laboratory, Faculté de Médecine de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.
authors.forename: N
authors.initials: N
authors.lastname: Jessel
authors.affiliation: INSERM (French National Institute of Health and Medical Research), UMR 1109, Osteoarticular and Dental Regenerative Nanomedicine Laboratory, Faculté de Médecine de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.|Department of periodontology, Dental Faculty, University of Strasbourg, Strasbourg, France.
authors.forename: H
authors.initials: H
authors.lastname: Tenenbaum
authors.affiliation: INSERM (French National Institute of Health and Medical Research), UMR 1109, Osteoarticular and Dental Regenerative Nanomedicine Laboratory, Faculté de Médecine de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.|Department of periodontology, Dental Faculty, University of Strasbourg, Strasbourg, France.
authors.forename: O
authors.initials: O
authors.lastname: Huck
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001688:Biological Products / Q000627:therapeutic use; D049109:Cell Proliferation; D016207:Cytokines / Q000037:antagonists & inhibitors; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D010519:Periodontium / Q000502:physiology*; D012038:Regeneration; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001688:Biological Products; D016207:Cytokines
keywords: cytokines; periodontitis; regenerative medicine; scaffold; wound healing