title: Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis.
abstract: Previously identified single nucleotide polymorphisms (SNPs) in genome wide association studies (GWAS) of cardiovascular disease (CVD) in participants of mostly European descent were tested for association with subclinical cardiovascular disease (sCVD), coronary artery calcium score (CAC) and carotid intima media thickness (CIMT) in the Multi-Ethnic Study of Atherosclerosis (MESA). The data in this data in brief article correspond to the article Common Genetic Variants and Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis [1]. This article includes the demographic information of the participants analyzed in the article as well as graphical displays and data tables of the association of the selected SNPs with CAC and of the meta-analysis across ethnicities of the association of CIMT-c (common carotid), CIMT-I (internal carotid), CAC-d (CAC as dichotomous variable with CAC>0) and CAC-c (CAC as continuous variable, the log of the raw CAC score plus one) and CVD. The data tables corresponding to the 9p21 fine mapping experiment as well as the power calculations referenced in the article are also included.
authors.affiliation: MedStar Health Research Institute, Georgetown University Hospital, Washington, District of Columbia, USA; National Institutes of Health, Radiology and Imaging Sciences, Bethesda, MD, USA.
authors.forename: Jose D
authors.initials: JD
authors.lastname: Vargas
authors.affiliation: Biostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA; Center for Public Health and Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
authors.forename: Ani
authors.initials: A
authors.lastname: Manichaikul
authors.affiliation: Biostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
authors.forename: Xin-Qun
authors.initials: XQ
authors.lastname: Wang
authors.affiliation: Center for Public Health and Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Rich
authors.affiliation: Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, CA, USA.
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.affiliation: Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Wendy S
authors.initials: WS
authors.lastname: Post
authors.affiliation: Department of Radiology, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Polak
authors.affiliation: Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Budoff
authors.affiliation: National Institutes of Health, Radiology and Imaging Sciences, Bethesda, MD, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
keywords: Carotid intima-media thickness (CIMT); Common genetic variant; Coronary artery calcium (CAC); Single nucleotide polymorphism (SNP); Subclincal atherosclerosis