title: [Thyroid function for infertile women during ovarian hyperstimulation as part of IVF].
abstract: OBJECTIVE
  Optimal thyroid function is necessary for an effective fertility. Many authors have suggested that thyroid function has an impact on IVF outcome. Conversely, IVF has been suggested to induce changes in thyroid function. The aim of this study was to determine the nature and the timing of alterations in thyroid function, throughout controlled ovarian hyperstimulation, from the beginning of therapy to the day of triggering ovulation. And make a clarification of the current recommendations of the thyroid function during hormonal stimulation.
  
  
  METHODS
  Subjects were recruited from March 2013 to July 2013 at the Hospital of the University of Reims. The studied population consisted of 50 infertile patients who had undergone IVF/ICSI cycles. Thyroid axis exploration was realized before therapy and at every hormonal dosage during ovarian monitorage.
  
  
  RESULTS
  Prematuary fluctuations were observed without impact on pregnancy rate. We could detect potential hypothyroid women thanks to this dosage and define a connection between pregnancy rate and TSH with a threshold closer to 1mUI/L than 2,5mUI/L defined by the endocrine society.
  
  
  CONCLUSIONS
  The link between thyroid function, forecast of conception and pregnancy is well documented. Currently, there is no recommendation on the rate of TSH targets for the patients in medical assisted procreation.
authors.affiliation: Service de gynécologie-obstétrique, centre hospitalo-universitaire de Reims, 45, rue Cognacq-Jay, 51092 Reims cedex, France. Electronic address: jburette@chu-reims.fr.
authors.forename: J
authors.initials: J
authors.lastname: Alnot-Burette
authors.affiliation: Service de biologie de la reproduction-CECOS, centre hospitalo-universitaire de Reims, 45, rue Cognacq-Jay, 51092 Reims cedex, France.
authors.forename: I
authors.initials: I
authors.lastname: Nakib
authors.affiliation: Service de gynécologie-obstétrique, centre hospitalo-universitaire de Reims, 45, rue Cognacq-Jay, 51092 Reims cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Lipere
authors.affiliation: Service endocrinologie, centre hospitalo-universitaire de Reims, rue du Général-Koenig, 51092 Reims cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Delemer
authors.affiliation: Service de gynécologie-obstétrique, centre hospitalo-universitaire de Reims, 45, rue Cognacq-Jay, 51092 Reims cedex, France.
authors.forename: O
authors.initials: O
authors.lastname: Graesslin
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D010062:Ovulation Induction; D011247:Pregnancy; D013959:Thyroid Diseases / Q000150:complications / Q000503:physiopathology; D013961:Thyroid Gland / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood; D016896:Treatment Outcome
chemical_list: D013972:Thyrotropin
keywords: Fertility treatment; Glande thyroïde; Hypothyroïdie; Infertility; Infertilité; Thyroid gland; Thyroid insufficiency; Traitement pour la fertilité