title: Targeted Treatment of a Rare Vaginal Sarcoma With an Anaplastic Lymphoma Kinase Inhibitor.
abstract: BACKGROUND
  Anaplastic lymphoma kinase is a tyrosine kinase receptor that can become oncogenic. Crizotinib is a tyrosine kinase inhibitor that shows activity in patients with anaplastic lymphoma kinase rearrangements that have failed conventional therapies.
  
  
  METHODS
  A 34-year-old woman presented with a painful 3-cm left vulvar-vaginal mass, which was excised and determined to be a sarcoma with positive surgical margins. Fluorescence in situ hybridization testing of her tumor was conducted and demonstrated anaplastic lymphoma kinase gene rearrangements. A 3-cm mass recurred 1 month later. Treatment with 250 mg crizotinib orally twice daily resulted in complete regression of all visible or palpable tumor within 3 weeks.
  
  
  CONCLUSIONS
  Molecular evaluation techniques can be used to direct targeted therapy for select malignancies. Future technologic advances will expand the number of malignancies for which these treatment approaches can be used.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California-Irvine Medical Center, Orange, and Kaiser Permanente, Southern California, Irvine, California.
authors.forename: Gareth K
authors.initials: GK
authors.lastname: Forde
authors.forename: Devansu
authors.initials: D
authors.lastname: Tewari
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D000077547:Crizotinib; D005260:Female; D006801:Humans; D011720:Pyrazoles / Q000494:pharmacology / Q000627:therapeutic use*; D011725:Pyridines / Q000494:pharmacology / Q000627:therapeutic use*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D012509:Sarcoma / Q000188:drug therapy* / Q000532:radiotherapy; D014625:Vaginal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy
chemical_list: D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases