title: Association of Advanced Glycation End Products with coronary Artery Calcification in Japanese Subjects with Type 2 Diabetes as Assessed by Skin Autofluorescence.
abstract: OBJECTIVE
  Advanced glycation end products (AGE) are considered to be among the critical pathogenic factors involved in the progression of diabetic complications. Skin autofluorescence (AF), a noninvasive measurement of AGE accumulation, has been recognized as a useful and convenient marker for diabetic vascular diseases in Caucasians. This study aimed to evaluate the association of tissue AGE, assessed using skin AF, with coronary artery calcification in Japanese subjects with type 2 diabetes.
  
  
  METHODS
  In total, 122 Japanese subjects with type 2 diabetes enrolled in this cross-sectional study underwent multi-slice computed tomography for total coronary artery calcium scores (CACS) estimation and examination with a skin AF reader.
  
  
  RESULTS
  Skin AF positively correlated with age, sex, diabetes duration, pulse wave velocity, systolic blood pressure, serum creatinine, and CACS. In addition, skin AF results negatively correlated with BMI, eGFR, and serum C-peptide concentration. According to multivariate analysis, age and systolic blood pressure showed strong positive correlation and eGFR showed negative correlation with skin AF values. Multiple linear regression analyses revealed a significant positive correlation between skin AF values and logCACS, independent of age, sex, diabetes duration, HbA1c, BMI, IMT, and blood pressure. However, skin AF showed no association with serum levels of AGE, such as Nε-(carboxymethyl) lysine and 3-deoxyglucosone.
  
  
  CONCLUSIONS
  Skin AF results positively correlated with CACS in Japanese subjects with type 2 diabetes. This result indicates that AGE plays a role in the pathogenesis of diabetic macrovascular disease. Measurement of skin AF values may be useful for assessing the severity of diabetic complications in Japanese subjects.
authors.affiliation: Division of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University.
authors.forename: Mari
authors.initials: M
authors.lastname: Hangai
authors.forename: Noriko
authors.initials: N
authors.lastname: Takebe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Honma
authors.forename: Atsumi
authors.initials: A
authors.lastname: Sasaki
authors.forename: Ai
authors.initials: A
authors.lastname: Chida
authors.forename: Rieko
authors.initials: R
authors.lastname: Nakano
authors.forename: Hirobumi
authors.initials: H
authors.lastname: Togashi
authors.forename: Riyuki
authors.initials: R
authors.lastname: Nakagawa
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Oda
authors.forename: Mizue
authors.initials: M
authors.lastname: Matsui
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yashiro
authors.forename: Kan
authors.initials: K
authors.lastname: Nagasawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kajiwara
authors.forename: Kazuma
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Jo
authors.initials: J
authors.lastname: Satoh
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ishigaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism*; D002114:Calcinosis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005453:Fluorescence; D006442:Glycated Hemoglobin / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D061848:Optical Imaging; D063177:Pulse Wave Analysis; D012307:Risk Factors; D012867:Skin / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced