title: Vulvar hidradenoma papilliferum (HP) is located on the sites of mammary-like anogenital glands (MLAGs): Analysis of the photographs of 52 tumors.
abstract: BACKGROUND
  Hidradenoma papilliferum (HP) is a benign tumor that primarily affects the anogenital area of adult women. Previously considered apocrine tumors, anogenital HP tumors are now interpreted as adenomas of mammary-like anogenital glands based on their histologic features.
  
  
  OBJECTIVE
  This clinical study was undertaken to determine whether vulvar HP is located on mammary-like anogenital gland sites and to describe its morphologic features.
  
  
  METHODS
  The clinical photographs of 52 histologically confirmed vulvar HP provided by 7 vulva specialists were analyzed.
  
  
  RESULTS
  In all, 90.4% of the HP were located on the interlabial sulcus, adjacent zone, or the perineum. These tumors were polymorphous in terms of number (1 or multiple), size (<1-4.5 cm), color (pink, red, blue), surface (ulcerated or not), and architecture (unilobular or multilobular).
  
  
  CONCLUSIONS
  Eight histologic reports could not be reviewed by the authors but the contributors confirmed that the photographs sent were only those of histologically confirmed HPs.
  
  
  CONCLUSIONS
  Vulvar HP is mainly located on mammary-like anogenital gland sites, thereby providing further evidence to their histogenesis. Although a nonulcerated or ulcerated tumor of the interlabial sulcus should evoke a HP diagnosis, the latter must be confirmed histologically.
authors.affiliation: Department of Dermatology, University Medical Center-Rizk Hospital, Beirut, Lebanon.
authors.forename: Jinane
authors.initials: J
authors.lastname: El-Khoury
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Hôtel-Dieu de Lévis, Montreal, Quebec, Canada.
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Renald
authors.affiliation: Department of Pathology, Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Paris, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Plantier
authors.affiliation: Department of Dermatology, Assistance Publique-Hôpitaux de Paris, Hôpital Cochin Tarnier, Paris, France; Faculté de Médecine Paris 5 Descartes, Paris, France.
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Avril
authors.affiliation: Department of Dermatology, Assistance Publique-Hôpitaux de Paris, Hôpital Cochin Tarnier, Paris, France. Electronic address: mmoyalbarracco@gmail.com.
authors.forename: Micheline
authors.initials: M
authors.lastname: Moyal-Barracco
mesh_terms: D018250:Acrospiroma / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001003:Anal Canal / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010502:Perineum / Q000473:pathology; D010781:Photography; D012189:Retrospective Studies; D013544:Sweat Gland Neoplasms / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000473:pathology*
keywords: Tyndall effect; adnexal tumor; hidradenoma papilliferum; mammary-like anogenital glands; mammary-like gland adenoma; papillary hidradenoma; vulva