title: A case-control study of interleukin-12 1188A/C polymorphism in obsessive-compulsive disorder in Chinese population.
abstract: OBJECTIVE
  Previous studies indicated that the levels of serum interleukin (IL)-12 at baseline were elevated in obsessive-compulsive disorder (OCD) patients compared with control subjects, suggesting that IL-12 maybe involved in the etiopathogenesis of OCD. Therefore, we study the relationship between 1188A/C polymorphism of IL-12(rs3212227) and OCD in Chinese Han population.
  
  
  METHODS
  We genotyped 194 OCD patients and 322 healthy individuals by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), then analyzed the data using case-control association test.
  
  
  RESULTS
  No significant differences were found in 1188A/C genotypic and allelic frequencies between OCD cases and controls ( X 2 = 2.12, df = 2, P = 0.35 by genotype; X 2 = 0.005, df = 1, P = 0.94 by allele).
  
  
  CONCLUSIONS
  Our results suggested that there may be lack of an association between OCD and IL-12 1188A/C polymorphism in Chinese Han population.
authors.affiliation: Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.affiliation: Departments of psychiatry and Psychological clinic, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Departments of psychiatry and Psychological clinic, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Departments of psychiatry and Psychological clinic, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Graduate school, Peking Union Medical College, Beijing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Ma