title: Grisemycin, a Bridged Angucyclinone with a Methylsulfinyl Moiety from a Marine-Derived Streptomyces sp.
abstract: Grisemycin (1), the first sulfur angucyclinone with an unusual ether-bridged system, was isolated from a marine-derived Streptomyces griseus strain M268. Its novel, here cage-like, structure was determined by spectroscopic analysis and single-crystal X-ray diffraction. Compound 1 exhibited modestly selective activity against the HL-60 cell line with an IC50 value of 31.54 μM. Futhermore, the absolute stereochemistry of kiamycin (2), an 1,12-epoxybenz[a]anthracene, previously obtained from the same strain, was established by X-ray diffraction analysis.
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, ‡School of Enology, and §School of Gerontology, Binzhou Medical University , Yantai 264003, China.
authors.forename: Zeping
authors.initials: Z
authors.lastname: Xie
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, ‡School of Enology, and §School of Gerontology, Binzhou Medical University , Yantai 264003, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, ‡School of Enology, and §School of Gerontology, Binzhou Medical University , Yantai 264003, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, ‡School of Enology, and §School of Gerontology, Binzhou Medical University , Yantai 264003, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, ‡School of Enology, and §School of Gerontology, Binzhou Medical University , Yantai 264003, China.
authors.forename: Guiwu
authors.initials: G
authors.lastname: Qu
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, ‡School of Enology, and §School of Gerontology, Binzhou Medical University , Yantai 264003, China.
authors.forename: Changjing
authors.initials: C
authors.lastname: Wu
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, ‡School of Enology, and §School of Gerontology, Binzhou Medical University , Yantai 264003, China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000880:Anthraquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D018922:HL-60 Cells; D056945:Hep G2 Cells; D006801:Humans; D007783:Lactones / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011758:Pyrroles / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*; D013305:Streptomyces griseus / Q000737:chemistry
chemical_list: D000880:Anthraquinones; D007783:Lactones; D011758:Pyrroles; C510997:angucyclinone; C000609756:grisemycin; C575073:kiamycin; C475865:marizomib