title: Sticking Around: Short-Range Activity of Wnt Ligands.
abstract: Wnt ligands are secreted lipid-modified proteins that are essential for development and homeostasis. Published recently in Nature, Farin et al. (2016) report that Wnt3 acts at a short distance during growth of mouse intestinal organoids, suggesting that Wnt proteins remain membrane-bound to activate signaling at a short range from their source.
authors.affiliation: Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg University, 69120 Heidelberg, Germany. Electronic address: m.boutros@dkfz.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Boutros
authors.affiliation: Division of Molecular Embryology, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany; Institute of Molecular Biology (IMB), 55128 Mainz, Germany.
authors.forename: Christof
authors.initials: C
authors.lastname: Niehrs
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D005260:Female; D007413:Intestinal Mucosa / Q000166:cytology*; D008297:Male; D055153:Stem Cell Niche; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D060508:Wnt3 Protein / Q000378:metabolism*
chemical_list: D060508:Wnt3 Protein