title: Past, Present, and Future of Dynamic Kidney and Liver Preservation and Resuscitation.
abstract: The increased demand for organs has led to the increased usage of "higher risk" kidney and liver grafts. These grafts from donation after circulatory death or expanded criteria donors are more susceptible to preservation injury and have a higher risk of unfavorable outcomes. Dynamic, instead of static, preservation could allow for organ optimization, offering a platform for viability assessment, active organ repair and resuscitation. Ex situ machine perfusion and in situ regional perfusion in the donor are emerging as potential tools to preserve and resuscitate vulnerable grafts. Preclinical findings have ignited clinical organ preservation research that investigates dynamic preservation, its various modes (continuous, preimplantation) and temperatures (hypo-, sub, or normothermic). This review outlines the current status of dynamic preservation of kidney and liver grafts and describes ongoing research and emerging clinical trials.
authors.affiliation: Abdominal Transplant Surgery, KU Leuven, University Hospitals Leuven, Leuven, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Jochmans
authors.affiliation: Biomedical Research Centre and Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Akhtar
authors.affiliation: Biomedical Research Centre and Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
authors.forename: D
authors.initials: D
authors.lastname: Nasralla
authors.affiliation: Department of General, Visceral and Transplant Surgery, University Hospital Essen, Essen, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Kocabayoglu
authors.affiliation: Biomedical Research Centre and Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
authors.forename: C
authors.initials: C
authors.lastname: Boffa
authors.affiliation: Biomedical Research Centre and Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
authors.forename: M
authors.initials: M
authors.lastname: Kaisar
authors.affiliation: Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Brat
authors.affiliation: Biomedical Research Centre and Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.|Clinical Effectiveness Unit, Centre for Evidence in Transplantation, Royal College of Surgeons of England, London, University of Oxford, Oxford, UK.
authors.forename: J
authors.initials: J
authors.lastname: O'Callaghan
authors.affiliation: Biomedical Research Centre and Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.|Clinical Effectiveness Unit, Centre for Evidence in Transplantation, Royal College of Surgeons of England, London, University of Oxford, Oxford, UK.
authors.forename: L H M
authors.initials: LH
authors.lastname: Pengel
authors.affiliation: Biomedical Research Centre and Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.|Clinical Effectiveness Unit, Centre for Evidence in Transplantation, Royal College of Surgeons of England, London, University of Oxford, Oxford, UK.
authors.forename: S
authors.initials: S
authors.lastname: Knight
authors.affiliation: Biomedical Research Centre and Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Ploeg
mesh_terms: D000818:Animals; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000639:trends*; D016031:Liver Transplantation / Q000639:trends*; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D012151:Resuscitation; D014019:Tissue Donors / Q000600:supply & distribution*
chemical_list: D019188:Organ Preservation Solutions
keywords: clinical research/practice; clinical trial; kidney transplantation/nephrology; liver transplantation/hepatology; organ perfusion and preservation; organ procurement and allocation