title: Evaluation of MEG vs EEG after sleep deprivation in epilepsy.
abstract: OBJECTIVE
  MEG and EEG after sleep deprivation (EEG-SD) are applied as diagnostic tools in the evaluation of patients with possible epilepsy. There is no gold standard to check whether the diagnosis based on these two modalities is correct. The best standard available is the long-term follow-up of patients. As follow-up of an earlier study in which the additional value of MEG vs EEG-SD diagnosis was evaluated, we investigated the long-term validity of MEG-based and EEG-SD-based diagnosis.
  
  
  METHODS
  Data collected from 46 patients were used in a comparative study of the last known diagnosis against the original one of 8 years ago.
  
  
  RESULTS
  Long-term (3-8 years) sensitivity of sharp phenomena (combining spikes and sharp waves) in routine MEG and in EEG-SD for the diagnosis epilepsy is 71% and 62%, respectively. When compared to the original study, this hardly changed. Over time, uncertainty on diagnosis diminishes.
  
  
  CONCLUSIONS
  MEG as well as EEG-SD are robust long-term predictors for epilepsy.
authors.affiliation: Department of Clinical Neurophysiology, ACE, location Kempenhaeghe, Heeze, The Netherlands.|Department of R&D, ACE, Heeze, The Netherlands.|Department of Neurology, Ghent University Hospital, Ghent, Belgium.
authors.forename: A J
authors.initials: AJ
authors.lastname: Colon
authors.affiliation: Department of Clinical Neurophysiology, VUmc, Amsterdam, The Netherlands.
authors.forename: H E
authors.initials: HE
authors.lastname: Ronner
authors.affiliation: Department of R&D, ACE, Heeze, The Netherlands.|Department of Neurology, Ghent University Hospital, Ghent, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Boon
authors.affiliation: Department of R&D, ACE, Heeze, The Netherlands.|Department of Clinical Physics, ACE, location Kempenhaeghe, Heeze, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Ossenblok
mesh_terms: D000328:Adult; D004569:Electroencephalography / Q000379:methods / Q000592:standards*; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods / Q000592:standards*; D008297:Male; D008875:Middle Aged; D012892:Sleep Deprivation / Q000175:diagnosis* / Q000503:physiopathology*; D011795:Surveys and Questionnaires
keywords: 
  MEG
  ; EEG after sleep deprivation; Validation; epilepsy diagnosis