title: Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease.
abstract: OBJECTIVE
  To analyze changes in telomere length (TL) after dialysis initiation.
  
  
  METHODS
  In 59 Japanese incident dialysis patients, associations between TL in peripheral blood leukocytes, inflammatory biomarkers and nutritional status at baseline and changes in TL during 1 year of dialysis, were investigated.
  
  
  RESULTS
  Whereas relative TL decreased by 8.6% (median 14.4%), TL elongation occurred in 16 patients (27%). Change in TL (x0394;TL), defined as TL at 1 year minus TL at baseline, was associated with baseline TL (x03C1; = -0.70, p < 0.0001) and leukocyte count (x03C1; = 0.26, p = 0.044). In a logistic regression model, baseline TL (p < 0.0001) and leukocyte count (p = 0.047) were associated with x0394;TL.
  
  
  CONCLUSIONS
  TL shortening was observed in most incident dialysis patients. In 16 of the 59 patients, TL elongation occurred, possibly reflecting a more robust biological aging in patients whose naïve leukocytes may have undergone less proliferation to replace lost leukocytes.
authors.affiliation: Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Sawako
authors.initials: S
authors.lastname: Kato
authors.forename: Paul G
authors.initials: PG
authors.lastname: Shiels
authors.forename: Dagmara
authors.initials: D
authors.lastname: McGuinness
authors.forename: Bengt
authors.initials: B
authors.lastname: Lindholm
authors.forename: Peter
authors.initials: P
authors.lastname: Stenvinkel
authors.forename: Louise
authors.initials: L
authors.lastname: Nordfors
authors.forename: Abdul Rashid
authors.initials: AR
authors.lastname: Qureshi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yuzawa
authors.forename: Seiichi
authors.initials: S
authors.lastname: Matsuo
authors.forename: Shoichi
authors.initials: S
authors.lastname: Maruyama
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016922:Cellular Senescence; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D060888:Real-Time Polymerase Chain Reaction; D006435:Renal Dialysis; D016615:Telomere / Q000737:chemistry* / Q000378:metabolism; D059505:Telomere Homeostasis; D059506:Telomere Shortening
chemical_list: D015415:Biomarkers