title: Prevalence and predictors of chronic kidney disease in newly diagnosed human immunodeficiency virus patients in Owerri, Nigeria.
abstract: Human immunodeficiency virus (HIV) infection is a common cause of chronic kidney disease (CKD) in Sub-Saharan Africa. This study aims at identifying the prevalence and predictors of CKD in newly diagnosed HIV patients in Owerri, South East Nigeria. This was a cross-sectional study consisting of 393 newly diagnosed HIV-seropositive subjects and 136 age- and sex-matched seronegative subjects as controls. CKD was defined as 24-hour urine protein (24-HUP) ≥0.3 g and/or glomerular filtration rate (GFR) < 60 ml/min. Subjects were recruited from the HIV clinic and the Medical Outpatient Department of Federal Medical Centre, Owerri. Clinical and anthropometric data were collected. Relevant investigations were performed, including HIV screening and relevant urine and blood investigations. The mean age of the HIV subjects was 38.84 ± 10.65 years. CKD was present in 86 (22.9%) HIV subjects and 11 (8.l %) controls. Low waist circumference (WC), high serum creatinine, high spot urine protein/creatinine ratio (SUPCR), high 24-HUP/creatinine Ratio (24-HUPCR), high 24-HUP/osmolality Ratio (24-HUPOR) predicted CKD in HIV subjects. CKD prevalence is high (22.9%) among newly diagnosed HIV patients in South East Nigeria. The predictors of CKD included WC, serum creatinine, SUPCR, 24-HUPCR, and 24-HUPOR.
authors.affiliation: Department of Medicine, Division of Nephrology, Federal Medical Centre, Owerri, Nigeria; Department of Medicine, Division of Nephrology, Imo State University Teaching Hospital, Orlu, Nigeria.
authors.forename: E N
authors.initials: EN
authors.lastname: Anyabolu
authors.affiliation: Department of Medicine, Division of Nephrology, Federal Medical Centre, Owerri, Nigeria; Department of Medicine, Division of Nephrology, Federal Medical Centre, Umuahia, Nigeria.
authors.forename: I I
authors.initials: II
authors.lastname: Chukwuonye
authors.affiliation: Department of Medicine, Division of Nephrology, University of Nigeria Teaching Hospital, Enugu, Nigeria.
authors.forename: E
authors.initials: E
authors.lastname: Arodiwe
authors.affiliation: Department of Medicine, Division of Nephrology, University of Nigeria Teaching Hospital, Enugu, Nigeria.
authors.forename: C K
authors.initials: CK
authors.lastname: Ijoma
authors.affiliation: Department of Medicine, Division of Nephrology, University of Nigeria Teaching Hospital, Enugu, Nigeria.
authors.forename: I
authors.initials: I
authors.lastname: Ulasi
keywords: Chronic kidney disease; human immune virus; spot urine creatinine; spot urine osmolality; spot urine protein