title: Cronkhite-Canada Syndrome: A Rare Cause of Chronic Diarrhoea in a Young Man.
abstract: A young Indian man presented with nine-month history of chronic diarrhea, occasionally mixed with blood and intermittent colicky abdominal pain. He also complained of generalized body swelling for the last three months. On examination, he had diffuse hyperpigmentation of the skin and dystrophic nail changes. Upper and lower gastrointestinal endoscopy revealed multiple sessile polyps in the stomach, small bowel, and colon and rectum. Biopsy of polyps showed adenomatous changes with stromal edema and dilated glands. Cronkhite-Canada syndrome (CCS) was diagnosed and treated with glucocorticoids and enteral nutritional supplementation. There was an associated small intestinal bacterial overgrowth (SIBO) and stool was positive for clostridium difficile toxin. After 12 weeks of treatment, the patient achieved remission. Close correlation with clinical findings, including pertinent ectodermal abnormalities, endoscopic studies, and careful examination of biopsies will ensure a timely and correct diagnosis of CCS.
authors.affiliation: Department of Accident and Emergency, Lady Hardinge Medical College, New Delhi, India.
authors.forename: Dhrubajyoti
authors.initials: D
authors.lastname: Bandyopadhyay
authors.affiliation: Department of Internal Medicine, IPGMER, Kolkata, India.
authors.forename: Adrija
authors.initials: A
authors.lastname: Hajra
authors.affiliation: Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.
authors.forename: Vijayan
authors.initials: V
authors.lastname: Ganesan
authors.affiliation: Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.
authors.forename: Suvrendu Sankar
authors.initials: SS
authors.lastname: Kar
authors.affiliation: Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.
authors.forename: Debarati
authors.initials: D
authors.lastname: Bhar
authors.affiliation: Lady Hardinge Medical College, New Delhi, India.
authors.forename: Manas
authors.initials: M
authors.lastname: Layek
authors.affiliation: R. G. Kar Medical College, Kolkata, India.
authors.forename: Sabyasachi
authors.initials: S
authors.lastname: Mukhopadhyay
authors.affiliation: Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.
authors.forename: Cankatika
authors.initials: C
authors.lastname: Choudhury
authors.affiliation: Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Choudhary
authors.affiliation: Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.
authors.forename: Prasun
authors.initials: P
authors.lastname: Banerjee