title: Exploiting Mitochondria In Vivo as Chemical Reaction Chambers Dependent on Membrane Potential.
abstract: Recently in Cell Metabolism, Logan et al. (2016) exploit membrane potential-dependent mitochondrial accumulation of charged precursors, causing them to combine by "click" chemistry 1,000,000 times faster than without accumulation to generate an ultrasensitive indicator for membrane potentials and foreshadow targeted drug synthesis in vivo.
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: agerencser@buckinstitute.org.
authors.forename: Akos A
authors.initials: AA
authors.lastname: Gerencser
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: mbrand@buckinstitute.org.
authors.forename: Martin D
authors.initials: MD
authors.lastname: Brand
mesh_terms: D053078:Membrane Potential, Mitochondrial; D008564:Membrane Potentials; D008928:Mitochondria / Q000378:metabolism*