title: Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.
abstract: Mitochondrial reactive oxygen species production has emerged as an important pathological mechanism in myocardial ischemia/reperfusion injury. Attempts at targeting reactive oxygen species by scavenging using antioxidants have, however, been clinically disappointing. This review will provide an overview of the current understanding of mitochondrial reactive oxygen species in ischemia/reperfusion injury. We will outline novel therapeutic approaches designed to directly target the mitochondrial respiratory chain and prevent excessive reactive oxygen species production and its associated pathology. This approach could lead to more effective interventions in an area where there is an urgent need for new treatments.
authors.affiliation: From the Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom (V.R.P., T.K.); Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (E.T.C.); Department of Cell Biology, Harvard Medical School, Boston, MA (E.T.C.); MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (M.P.M.); and Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY (P.S.B.).
authors.forename: Victoria R
authors.initials: VR
authors.lastname: Pell
authors.affiliation: From the Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom (V.R.P., T.K.); Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (E.T.C.); Department of Cell Biology, Harvard Medical School, Boston, MA (E.T.C.); MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (M.P.M.); and Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY (P.S.B.).
authors.forename: Edward T
authors.initials: ET
authors.lastname: Chouchani
authors.affiliation: From the Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom (V.R.P., T.K.); Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (E.T.C.); Department of Cell Biology, Harvard Medical School, Boston, MA (E.T.C.); MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (M.P.M.); and Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY (P.S.B.).
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murphy
authors.affiliation: From the Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom (V.R.P., T.K.); Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (E.T.C.); Department of Cell Biology, Harvard Medical School, Boston, MA (E.T.C.); MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (M.P.M.); and Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY (P.S.B.).
authors.forename: Paul S
authors.initials: PS
authors.lastname: Brookes
authors.affiliation: From the Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom (V.R.P., T.K.); Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (E.T.C.); Department of Cell Biology, Harvard Medical School, Boston, MA (E.T.C.); MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (M.P.M.); and Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY (P.S.B.). tk382@medschl.cam.ac.uk.
authors.forename: Thomas
authors.initials: T
authors.lastname: Krieg
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000639:trends; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D002317:Cardiovascular Agents; D017382:Reactive Oxygen Species
keywords: antioxidants; mitochondria; oxygen; reactive oxygen species; reperfusion injury