title: Obesity and Metabolic Syndrome Among Adult Survivors of Childhood Leukemia.
abstract: Treatment-related obesity and the metabolic syndrome in adult survivors of childhood acute lymphoblastic leukemia (ALL) are risk factors for cardiovascular disease. Both conditions often begin during therapy. Preventive measures, including dietary counseling and tailored exercise, should be initiated early in the course of survivorship, with referral to specialists to optimize success. However, among adults who develop obesity or the metabolic syndrome and who do not respond to lifestyle therapy, medical intervention may be indicated to manage underlying pathology, such as growth hormone deficiency, or to mitigate risk factors of cardiovascular disease. Because no specific clinical trials have been done in this population to treat metabolic syndrome or its components, clinicians who follow adult survivors of childhood ALL should use the existing American Heart Association/National Heart Lung and Blood Institute Scientific Statement to guide their approach.
authors.affiliation: Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 735, Memphis, TN, 38105, USA. todd.gibson@stjude.org.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Gibson
authors.affiliation: Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 735, Memphis, TN, 38105, USA. matt.ehrhardt@stjude.org.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Ehrhardt
authors.affiliation: Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 735, Memphis, TN, 38105, USA. kiri.ness@stjude.org.
authors.forename: Kirsten K
authors.initials: KK
authors.lastname: Ness
mesh_terms: D050154:Adiposity; D017668:Age of Onset; D001823:Body Composition; D016371:Cranial Irradiation / Q000009:adverse effects; D019468:Disease Management; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D009765:Obesity / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000453:epidemiology* / Q000628:therapy; D015995:Prevalence; D012307:Risk Factors; D017741:Survivors
keywords: Acute lymphoblastic leukemia; Childhood; Cranial radiation; Glucocorticoids; Growth hormone deficiency; Lifestyle; Metabolic syndrome; Obesity; Pediatrics; Survivor