title: An Association Study of the SLC19A1 Gene Polymorphisms/Haplotypes with Idiopathic Recurrent Pregnancy Loss in an Iranian Population.
abstract: OBJECTIVE
  The genetics of folate metabolism is one of the most significant mechanisms influencing fetal growth and may underlie some cases of unexplained recurrent miscarriage. Reduced folate carrier 1, encoded by the SLC19A1 gene, is a transporter of folate. Folate deficiency and elevated levels of homocysteine could be disadvantageous for the female reproductive system health. Thus, the balance between homocysteine and folate status can be used to measure the risk of recurrent pregnancy loss.
  
  
  METHODS
  The purpose of this study was to determine the association between -43T>C, 80G>A, and 696C>T polymorphisms of the SLC19A1 gene in 147 women who had unexplained recurrent miscarriage in comparison with 150 healthy women. Amplification refractory mutation system-polymerase chain reaction was used to genotype the molecular polymorphisms of this gene.
  
  
  RESULTS
  The results indicated that the -43T>C single nucleotide of the SLC19A1 gene was significantly associated with a risk of recurrent miscarriage in Iranian women (p < 0.05). No significant association was observed for the other two polymorphisms. The haplotype frequency distribution of -43C/80G/696C, -;43C/80G/696T, -43C/80G, and 80G/696T was significantly different in patients than controls, which may represent a novel risk factor for idiopathic recurrent pregnancy loss.
  
  
  CONCLUSIONS
  Polymorphisms and haplotypes of the SLC19A1 gene can be considered risk factors for idiopathic recurrent pregnancy loss.
authors.affiliation: 1 International Campus of Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran .
authors.forename: Shirin
authors.initials: S
authors.lastname: Mohtaram
authors.affiliation: 1 International Campus of Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran .
authors.forename: Mohammad Hasan
authors.initials: MH
authors.lastname: Sheikhha
authors.affiliation: 1 International Campus of Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran .
authors.forename: Negar
authors.initials: N
authors.lastname: Honarvar
authors.affiliation: 1 International Campus of Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran .
authors.forename: Ali
authors.initials: A
authors.lastname: Sazegari
authors.affiliation: 1 International Campus of Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran .
authors.forename: Neda
authors.initials: N
authors.lastname: Maraghechi
authors.affiliation: 1 International Campus of Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran .
authors.forename: Zahra
authors.initials: Z
authors.lastname: Feizollahi
authors.affiliation: 2 Recurrent Abortion Research Centre, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences , Yazd, Iran .
authors.forename: Nasrin
authors.initials: N
authors.lastname: Ghasemi
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007492:Iran; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D058978:Reduced Folate Carrier Protein / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D058978:Reduced Folate Carrier Protein; C548699:SLC19A1 protein, human