title: (-)-Epicatechin in vitro ameliorates erythrocyte protein carbonyl content in hypertensive patients: comparison with L-ascorbic acid.
abstract: BACKGROUND
  Oxidative stress plays a key role in the patho-physiology of hypertension. (-)-Epicatechin has many important biological properties.
  
  
  OBJECTIVE
  The present study was undertaken to evaluate effect of (-)-epicatechin on protein carbonyl content in gender-based hypertensive patients and normal subjects.
  
  
  METHODS
  The study was carried out on 83 normal (male: 42; female: 41) and 62 hypertensive subjects (male: 32; female: 30). In vitro effect on (-)-epicatechin and L-ascorbic acid was estimated on protein carbonyl content.
  
  
  RESULTS
  Result showed a significant (p < 0.001) increase in protein carbonyl content in hypertensive patients but no gender-based difference was observed. (-)-epicatechin shows significant (p < 0.001) dose-dependent effect as compared to L-ascorbic acid, which is manifested as decrease in protein carbonyl content.
  
  
  CONCLUSIONS
  We hypothesizes that a higher intake of (-)-epicatechin may provide protection against hypertension in males and females.
authors.affiliation: a School of Medicine, College of Medicine and Health Sciences, Wollo University , Dessie , Ethiopia .|b Department of Biochemistry , University of Allahabad , Allahabad , Uttar Pradesh , India .
authors.forename: Navneet
authors.initials: N
authors.lastname: Kumar
authors.affiliation: c Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo , São Paulo , Brazil .|d Amity Institute of Biotechnology, Amity University , Noida , Uttar Pradesh , India , and.
authors.forename: Pawan Kumar
authors.initials: PK
authors.lastname: Maurya
authors.affiliation: e Department of Chemistry , College of Natural Science, Wollo University , Dessie , Ethiopia.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Kant
authors.affiliation: b Department of Biochemistry , University of Allahabad , Allahabad , Uttar Pradesh , India .
authors.forename: Syed Ibrahim
authors.initials: SI
authors.lastname: Rizvi
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology*; D016022:Case-Control Studies; D002392:Catechin / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D050050:Protein Carbonylation / Q000187:drug effects*; D011506:Proteins / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D011506:Proteins; D002392:Catechin; D001205:Ascorbic Acid
keywords: Carbonyl group; epicatechin; erythrocyte; hypertension; oxidative stress