title: AMPK Promotes Autophagy by Facilitating Mitochondrial Fission.
abstract: AMPK senses decreased cellular energy levels, triggering mitochondrial autophagy or mitophagy through activating ULK1 and inhibiting mTORC1. In a recent report, Toyama et al. (2016) show that activated AMPK phosphorylation of MFF is critical for mitochondrial fission. Unphosphorylatable MFF mutants block mitophagy, connecting AMPK to mitochondrial fission and to mitophagy.
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.
authors.forename: Chen-Song
authors.initials: CS
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: linsc@xmu.edu.cn.
authors.forename: Sheng-Cai
authors.initials: SC
authors.lastname: Lin
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D063154:Mitochondrial Dynamics; D013312:Stress, Physiological
chemical_list: D055372:AMP-Activated Protein Kinases