title: The Oxidant and Antioxidant Status in Pityriasis Rosea.
abstract: BACKGROUND
  Pityriasis rosea (PR) is usually an asymptomatic and self-limiting papulosquamous skin disease with acute onset. The etiology has not been clarified yet. Recently, increased oxidative stress was found to play a role in etiopathogenesis of multiple cutaneous diseases with T cell-mediated immune response. However, there are no studies demonstrating the oxidative stress status in PR.
  
  
  OBJECTIVE
  The aim of the study is to determine the status of oxidative stress (OS) and paraoxonase (PON) 1/arylesterase enzyme activities in PR.
  
  
  METHODS
  Study included 51 patients with active PR lesions, and 45 healthy volunteers. Serum levels of total oxidant status (TOS), total antioxidant status (TAS), and PON1/arylesterase (ARES) activity were determined and oxidative stress index (OSI) was calculated in all patients and controls.
  
  
  RESULTS
  TAS levels and ARES activities in the patient group were significantly lower than the control group. On the other hand, TOS and OSI levels were significantly higher in patients compared with controls. There was no significant correlation between the duration of disease and TAS, TOS, OSI levels, and ARES activities.
  
  
  CONCLUSIONS
  A systemic oxidative stress exists in PR, which suggests that OS may be involved in the etiopathogenesis of disease.
authors.affiliation: Dermatology Clinic, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Selma
authors.initials: S
authors.lastname: Emre
authors.affiliation: Dermatology Clinic, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Gulsen
authors.initials: G
authors.lastname: Akoglu
authors.affiliation: Dermatology Clinic, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Metin
authors.affiliation: Dermatology Clinic, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Duriye Deniz
authors.initials: DD
authors.lastname: Demirseren
authors.affiliation: Department of Biochemistry, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Semra
authors.initials: S
authors.lastname: Isikoglu
authors.affiliation: Dermatology Clinic, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Aynure
authors.initials: A
authors.lastname: Oztekin
authors.affiliation: Department of Biochemistry, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
keywords: Antioxidant status; arylesterase activity; oxidant status; oxidative stress; pityriasis rosea