title: PD-1/PD-L1 expression in non-small-cell lung cancer and its correlation with EGFR/KRAS mutations.
abstract: This study was aimed to detect the correlation among EGFR/KRAS status and PD-1/PD-L1 expression in non-small-cell lung cancer (NSCLC) patients. PD-1 and PD-L1 expressions were detected by immunohistochemistry in 100 surgically resected lung adenocarcinoma tissues and were statistically correlated with clinicopathological characteristics including EGFR and KRAS statuses. Besides, the overall survival (OS) times were analyzed. There was a statistical significances between PD-1 expression in tumor and KRAS status (P = 0.043), with a higher mutation rate in with lower PD-1 expression patients. There was a statistical significance between PD-L1 expression in tumor and EGFR status (P = 0.012), with a higher mutation rate in patients with lower PD-L1 expression. The OS of patients with EGFR mutation was significantly longer than those without EGFR mutation. The OS of patients with lower PD-L1 in tumor was significantly longer than those with higher PD-L1 expression. We found negative associations between PD-L1 expression in tumor and mutated EGFR status, as well as between PD-1 expression in tumor and mutated KRAS status.
authors.affiliation: a Department of Oncology , The Third Affiliated Hospital of Soochow University , Changzhou , China.|b Jiangsu Engineering Research Center for Tumor Immunotherapy , Changzhou , China.
authors.forename: Mei
authors.initials: M
authors.lastname: Ji
authors.affiliation: c Department of Hematology , The Third Affiliated Hospital of Soochow University , Changzhou , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: d Department of Pathology , The Third Affiliated Hospital of Soochow University , Changzhou , China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: a Department of Oncology , The Third Affiliated Hospital of Soochow University , Changzhou , China.|b Jiangsu Engineering Research Center for Tumor Immunotherapy , Changzhou , China.|e Department of Biological Treatment , The Third Affiliated Hospital of Soochow University , Changzhou , China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
authors.affiliation: f Department of Radiation Oncology , The Third Affiliated Hospital of Soochow University , Changzhou , China.
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Ning
authors.affiliation: a Department of Oncology , The Third Affiliated Hospital of Soochow University , Changzhou , China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Zhao
authors.affiliation: a Department of Oncology , The Third Affiliated Hospital of Soochow University , Changzhou , China.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shi
authors.affiliation: b Jiangsu Engineering Research Center for Tumor Immunotherapy , Changzhou , China.|e Department of Biological Treatment , The Third Affiliated Hospital of Soochow University , Changzhou , China.
authors.forename: Jingting
authors.initials: J
authors.lastname: Jiang
authors.affiliation: a Department of Oncology , The Third Affiliated Hospital of Soochow University , Changzhou , China.|b Jiangsu Engineering Research Center for Tumor Immunotherapy , Changzhou , China.|e Department of Biological Treatment , The Third Affiliated Hospital of Soochow University , Changzhou , China.
authors.forename: Changping
authors.initials: C
authors.lastname: Wu
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D061026:Programmed Cell Death 1 Receptor / Q000378:metabolism*; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D016019:Survival Analysis
chemical_list: C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D066246:ErbB Receptors; D016283:Proto-Oncogene Proteins p21(ras)
keywords: EGFR; KRAS; PD-1; PD-L1; non-small-cell lung cancer