title: An Associative Memory Model for Integration of Fragmented Research Data and Identification of Treatment Correlations in Breast Cancer Care.
abstract: A major challenge in advancing scientific discoveries using data-driven clinical research is the fragmentation of relevant data among multiple information systems. This fragmentation requires significant data-engineering work before correlations can be found among data attributes in multiple systems. In this paper, we focus on integrating information on breast cancer care, and present a novel computational approach to identify correlations between administered drugs captured in an electronic medical records and biological factors obtained from a tumor registry through rapid data aggregation and analysis. We use an associative memory (AM) model to encode all existing associations among the data attributes from both systems in a high-dimensional vector space. The AM model stores highly associated data items in neighboring memory locations to enable efficient querying operations. The results of applying AM to a set of integrated data on tumor markers and drug administrations discovered anomalies between clinical recommendations and derived associations.
authors.affiliation: General Electric Global Research, Niskayuna, NY.
authors.forename: Ashis Gopal
authors.initials: AG
authors.lastname: Banerjee
authors.affiliation: Department of Computer Science.
authors.forename: Mridul
authors.initials: M
authors.lastname: Khan
authors.affiliation: Department of Biomedical Data Science, Dartmouth College, Hanover, NH.
authors.forename: John
authors.initials: J
authors.lastname: Higgins
authors.affiliation: General Electric Global Research, Niskayuna, NY.
authors.forename: Annarita
authors.initials: A
authors.lastname: Giani
authors.affiliation: Department of Biomedical Data Science, Dartmouth College, Hanover, NH.
authors.forename: Amar K
authors.initials: AK
authors.lastname: Das
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000737:chemistry / Q000628:therapy*; D003198:Computer Simulation; D057286:Electronic Health Records / Q000458:organization & administration*; D005260:Female; D006801:Humans; D008498:Medical Record Linkage / Q000379:methods*; D008954:Models, Biological; D012042:Registries; D018511:Systems Integration
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
keywords: Associative memory; breast cancer treatment; correlation; data integration; electronic medical record; tumor registry