title: Synthesis, spectral studies and biological evaluation of 2-aminonicotinic acid metal complexes.
abstract: We synthesized 2-aminonicotinic acid (2-ANA) complexes with metals such as Co(II), Fe(III), Ni(II), Mn(II), Zn(II), Ag(I),Cr(III), Cd(II) and Cu(II) in aqueous media. The complexes were characterized and elucidated using FT-IR, UV-Vis, a fluorescence spectrophotometer and thermo gravimetric analysis (TGA). TGA data showed that the stoichiometry of complexes was 1:2 metal/ligand except for Ag(I) and Mn(II) where the ratio was 1:1. The metal complexes showed varied antibacterial, fungicidal and nematicidal activities. The silver and zinc complexes showed highest activity against Bacillus subtilis and Bacillus licheniformis respectively. Fusarium oxysporum was highly susceptible to nickel and copper complexes whereas Macrophomina phaseolina was completely inert to the complexes. The silver and cadmium complexes were effective against the root-knot nematode Meloidogyne javanica.
authors.affiliation: Department of Nano-Medicine, Institute for Research and Medical Consultations, University of Dammam, Dammam, Saudi Arabia. Electronic address: nawwaz@gmail.com.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Nawaz
authors.affiliation: Department of Botany, University of Karachi, Karachi 75250, Pakistan.
authors.forename: Muhammad Waseem
authors.initials: MW
authors.lastname: Abbasi
authors.affiliation: Department of Chemistry, United Arab Emirates University, Al-Ain 15551, United Arab Emirates.
authors.forename: Soleiman
authors.initials: S
authors.lastname: Hisaindee
authors.affiliation: Department of Botany, University of Karachi, Karachi 75250, Pakistan.
authors.forename: Muhammad Javed
authors.initials: MJ
authors.lastname: Zaki
authors.affiliation: Department of Pharmacology, College of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Hira Fatima
authors.initials: HF
authors.lastname: Abbas
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, PR China.
authors.forename: Hu
authors.initials: H
authors.lastname: Mengting
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: M Arif
authors.initials: MA
authors.lastname: Ahmed
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008670:Metals / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy; D009539:Nicotinic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D056831:Coordination Complexes; D008670:Metals; D009539:Nicotinic Acids; C110415:2-aminonicotinic acid
keywords: 2-Aminonicotinic acid; Biological activity; Metal complexes; Spectral studies