title: The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review.
abstract: Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD.
authors.affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA. jnc43@case.edu.|Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA. jnc43@case.edu.
authors.forename: Jessica N
authors.initials: JN
authors.lastname: Cooke Bailey
authors.affiliation: Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158, USA. joshua.hoffman@ucsf.edu.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Hoffman
authors.affiliation: John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. r.sardell@med.miami.edu.
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Sardell
authors.affiliation: John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. bscott@med.miami.edu.
authors.forename: William K
authors.initials: WK
authors.lastname: Scott
authors.affiliation: John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. mpericak@med.miami.edu.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Pericak-Vance
authors.affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA. jlh213@case.edu.|Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA. jlh213@case.edu.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Haines
keywords: age-related macular degeneration (AMD); genetics; risk score