title: Breastfeeding and Immunohistochemical Expression of ki-67, p53 and BCL2 in Infiltrating Lobular Breast Carcinoma.
abstract: OBJECTIVE
  Invasive lobular breast carcinoma is the second most common type of breast cancer after invasive ductal carcinoma. According to the American Cancer Society, more than 180,000 women in the United States find out they have invasive breast cancer each year. Personal history of breast cancer and certain changes in the breast are correlated with an increased breast cancer risk. The aim of this work was to analyze breastfeeding in patients with infiltrating lobular breast carcinoma, in relation with: 1) clinicopathological parameters, 2) hormonal receptors and 3) tissue-based tumor markers.
  
  
  METHODS
  The study included 80 women with ILC, 46 of which had breastfeed their children. Analyzed parameters were: age, tumor size, axillary lymph node (N), distant metastasis (M), histological grade (HG), estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), Ki-67, p53 and BCL2.
  
  
  RESULTS
  ILC of non-lactating women showed a larger (p = 0.009), lymph node involvement (p = 0.051) and distant metastasis (p = 0.060). They were also more proliferative tumors measured by Ki-67 (p = 0.053). Breastfeeding history did not influence the subsequent behavior of the tumor regardless of histological subtype.
  
  
  CONCLUSIONS
  Lactation seems to influence the biological characteristics of ILC defining a subgroup with more tumor size, axillary lymph node involvement, distant metastasis and higher proliferation measured by ki-67 expression.
authors.affiliation: Department of Physiological Sciences II, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Gonzalez-Sistal
authors.affiliation: Department of Physiological Sciences II, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Baltasar-Sánchez
authors.affiliation: Pathology Service, Hospital Central de Asturias, Oviedo, Spain.
authors.forename: Primitiva
authors.initials: P
authors.lastname: Menéndez
authors.affiliation: Surgery Service, Hospital Monte del Naranco, Oviedo, Spain.
authors.forename: Jose Ignacio
authors.initials: JI
authors.lastname: Arias
authors.affiliation: Nuclear Medicine Service, Complejo Hospitalario Universitario, Faculty of Medicine, IDIS, Santiago de Compostela, Fundación Tejerina, Madrid, Spain.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Ruibal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000473:pathology*; D001942:Breast Feeding; D001943:Breast Neoplasms / Q000453:epidemiology / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: C000595707:BCL2 protein, human; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53