title: (Compl)Ex-Th17-Tregcell inter-relationship.
abstract: Codependent development and Th17-to-FoxP3+T cell inter-conversion account for the enigmatic coexistence of IL17-producing and FoxP3+cells in tumor-associated inflammation. In addition to Tregcells, exTh17-FoxP3+cells present a novel subpopulation of FoxP3+cells. Yin-yang of IL17+and FoxP3+cells presents an important principle for improved approaches in cancer immunotherapy.
authors.affiliation: Division of Surgical Oncology; University of Pittsburgh; Hillman Cancer Center ; Pittsburgh, PA, USA.
authors.forename: Nataša
authors.initials: N
authors.lastname: Obermajer
authors.affiliation: Department of Surgery; University Medical Center Regensburg ; Regensburg, Germany.
authors.forename: Marc H
authors.initials: MH
authors.lastname: Dahlke
keywords: T cell plasticity; Th17 cells; myeloid-derived suppressor cells; regulatory T cells; sterile inflammation