title: Reactivation of Reward-Related Patterns from Single Past Episodes Supports Memory-Based Decision Making.
abstract: Rewarding experiences exert a strong influence on later decision making. While decades of neuroscience research have shown how reinforcement gradually shapes preferences, decisions are often influenced by single past experiences. Surprisingly, relatively little is known about the influence of single learning episodes. Although recent work has proposed a role for episodes in decision making, it is largely unknown whether and how episodic experiences contribute to value-based decision making and how the values of single episodes are represented in the brain. In multiple behavioral experiments and an fMRI experiment, we tested whether and how rewarding episodes could support later decision making. Participants experienced episodes of high reward or low reward in conjunction with incidental, trial-unique neutral pictures. In a surprise test phase, we found that participants could indeed remember the associated level of reward, as evidenced by accurate source memory for value and preferences to re-engage with rewarded objects. Further, in a separate experiment, we found that high-reward objects shown as primes before a gambling task increased financial risk taking. Neurally, re-exposure to objects in the test phase led to significant reactivation of reward-related patterns. Importantly, individual variability in the strength of reactivation predicted value memory performance. Our results provide a novel demonstration that affect-related neural patterns are reactivated during later experience. Reactivation of value information represents a mechanism by which memory can guide decision making.
authors.affiliation: Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 20246 elliott@caa.columbia.edu.
authors.forename: G Elliott
authors.identifier: http://orcid.org/0000-0002-2227-119X
authors.initials: GE
authors.lastname: Wimmer
authors.affiliation: Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 20246.
authors.forename: Christian
authors.initials: C
authors.lastname: Büchel
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D003463:Cues; D003657:Decision Making / Q000502:physiology*; D030141:Feedback, Psychological; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010146:Pain / Q000523:psychology; D011930:Reaction Time / Q000502:physiology; D012054:Reinforcement, Psychology; D012201:Reward; D012309:Risk-Taking; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: decision making; memory; multivariate; reward; reward learning