title: [COMBINATION OF CELLS TECHNOLOGIES AND MINSIINVASIVE SURGERY IN THE TREATMENT OF CHRONIC GASTRIC ULCER].
abstract: The results of experimental and clinical use of stimulants of local reparative processes (autologous purified lipoaspirate and platelet-rich plasma) in the treatment of chronic gastric ulcer were analyzed. In the experimental part of the study the benefits of using platelet-rich plasma as donator growth factors were proved. The ability to stimulate the activity of fibroblasts and vessels formation in the young connective tissue with improving of oxygenation in ulcers and enhancing of cell proliferation, differentiation and accelerating of connective tissue maturation and healing of ulcers were demonstrated. In clinical studies the advantages of combination of standard antiulcer therapy and local endoscopic injection of platelet-rich plasma compared to only conservative therapy were shown.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Usenko
authors.forename: Ya V
authors.initials: YV
authors.lastname: Radyoha
authors.forename: D I
authors.initials: DI
authors.lastname: Grebeniuk
authors.forename: O K
authors.initials: OK
authors.lastname: Stukan
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002908:Chronic Disease; D004195:Disease Models, Animal; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D053657:Platelet-Rich Plasma / Q000737:chemistry / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000473:pathology / Q000601:surgery* / Q000628:therapy*; D014182:Transplantation, Autologous
chemical_list: D036341:Intercellular Signaling Peptides and Proteins