title: Otologic evaluation of patients with primary antibody deficiency.
abstract: Common variable immunodeficiency (CVID) represents the most frequent primary immunodeficiency, often encountered in the ENT clinical practice. The clinical spectrum of CVID is quite broad, but otitis media are certainly among the most common clinical manifestations. This prospective study enrolled 60 patients (34 males, 26 females) with a previous diagnosis of CVID with the aim of performing an otologic evaluation and a more precision characterization of incidence, diagnosis, and treatment of otitis media in this group of patients. In consideration that Eustachian tube dysfunction (ETD) could be the 'primum movens' of otitis media, we wanted to assess whether a Eustachian tube dysfunction was present in these patients. Besides, we propose a possible diagnostic algorithm of middle ear pathologies to use in all cases of primary antibody deficiency patients. Results of our otologic examination showed that: 5 % of patients had chronic suppurative otitis media, 25 % bilateral otitis media with effusion and 10 % reported unilateral OME with associated contralateral ETD. There was bilateral isolated ETD and unilateral isolated ETD in 5 and 15 % of patients, respectively. All patients with unilateral OME had associated contralateral ETD. Finally, 40 % of patients were bilaterally negative at otoscopic examination and all otologic tests.
authors.affiliation: 'Organi di Senso' Department, 'Sapienza' University of Rome, Via Gregorio VII n. 80, 00165, Rome, Italy. giuseppemagliuloorl@yahoo.com.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Magliulo
authors.affiliation: 'Organi di Senso' Department, 'Sapienza' University of Rome, Via Gregorio VII n. 80, 00165, Rome, Italy.
authors.forename: Giannicola
authors.initials: G
authors.lastname: Iannella
authors.affiliation: 'Organi di Senso' Department, 'Sapienza' University of Rome, Via Gregorio VII n. 80, 00165, Rome, Italy.|Department of Molecular Medicine, La Sapienza University, Rome, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Granata
authors.affiliation: 'Organi di Senso' Department, 'Sapienza' University of Rome, Via Gregorio VII n. 80, 00165, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ciofalo
authors.affiliation: 'Organi di Senso' Department, 'Sapienza' University of Rome, Via Gregorio VII n. 80, 00165, Rome, Italy.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Pasquariello
authors.affiliation: 'Organi di Senso' Department, 'Sapienza' University of Rome, Via Gregorio VII n. 80, 00165, Rome, Italy.
authors.forename: Diletta
authors.initials: D
authors.lastname: Angeletti
authors.affiliation: 'Organi di Senso' Department, 'Sapienza' University of Rome, Via Gregorio VII n. 80, 00165, Rome, Italy.|Department of Molecular Medicine, La Sapienza University, Rome, Italy.
authors.forename: Fabiola
authors.initials: F
authors.lastname: La Marra
authors.affiliation: 'Organi di Senso' Department, 'Sapienza' University of Rome, Via Gregorio VII n. 80, 00165, Rome, Italy.|Department of Molecular Medicine, La Sapienza University, Rome, Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Quinti
mesh_terms: D000158:Acoustic Impedance Tests / Q000379:methods; D000328:Adult; D000368:Aged; D000465:Algorithms; D002908:Chronic Disease; D017074:Common Variable Immunodeficiency / Q000150:complications*; D004432:Ear, Middle / Q000503:physiopathology; D005064:Eustachian Tube / Q000503:physiopathology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010033:Otitis Media / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D010034:Otitis Media with Effusion / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D010035:Otitis Media, Suppurative / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D011446:Prospective Studies; D011795:Surveys and Questionnaires
chemical_list: D007136:Immunoglobulins
keywords: Chronic suppurative otitis media; Common variable immunodeficiency; Eustachian tube; Otitis media with effusion