title: Photosensitizer-Conjugated Hyaluronic Acid-Shielded Polydopamine Nanoparticles for Targeted Photomediated Tumor Therapy.
abstract: Photodynamic therapy (PDT) is a widely used clinical option for tumor therapy. However, the clinical utilization of conventional small-molecule photosensitizers (PSs) for PDT has been limited by their low selectivity for disease sites, and undesirable photoactivation. To overcome these limitations, we demonstrated a tumor-specific and photoactivity-controllable nanoparticle photomedicine based on a combination of PS-biomacromolecule conjugates and polydopamine nanoparticles (PD-NP) for an effective tumor therapy. This novel photomedicine consisted of a PD-NP core and a PS-conjugated hyaluronic acid (PS-HA) shell. The PD-NP and the PS-HA play roles as a quencher for PSs and a cancer targeting moiety, respectively. The synthesized PS-HA-shielded PD-NPs (PHPD-NPs) had a relatively narrow size distribution (approximately 130 nm) with uniform spherical shapes. In response to cancer-specific intracellular enzymes (e.g., hyaluronidase), the PHPD-NPs exhibited an excellent singlet oxygen generation capacity for PDT. Furthermore, an efficient photothermal conversion ability for photothermal therapy (PTT) was also shown in the PHPD-NPs system. These properties provide superior therapeutic efficacy against cancer cells. In mice tumor model, the photoactive restorative effects of the PHPD-NPs were much higher in cancer microenvironments compared to that in the normal tissue. As a result, the PHPD-NPs showed a significant antitumor activity in in vivo mice tumor model. The nanoparticle photomedicine design is a novel strategy for effective tumor therapy.
authors.affiliation: Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea , 43 Jibongro, Wonmi-gu, Bucheon-si, Gyeonggi do 14662, Republic of Korea.
authors.forename: Jieun
authors.initials: J
authors.lastname: Han
authors.affiliation: Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea , 43 Jibongro, Wonmi-gu, Bucheon-si, Gyeonggi do 14662, Republic of Korea.
authors.forename: Wooram
authors.initials: W
authors.lastname: Park
authors.affiliation: Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea , 43 Jibongro, Wonmi-gu, Bucheon-si, Gyeonggi do 14662, Republic of Korea.
authors.forename: Sin-Jung
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea , 43 Jibongro, Wonmi-gu, Bucheon-si, Gyeonggi do 14662, Republic of Korea.
authors.forename: Kun
authors.initials: K
authors.lastname: Na
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006820:Hyaluronic Acid / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000628:therapy*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D010789:Phototherapy / Q000379:methods*; D011108:Polymers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D007211:Indoles; D017319:Photosensitizing Agents; D011108:Polymers; C568283:polydopamine; D006820:Hyaluronic Acid
keywords: nanoparticles; photodynamic therapy (PDT); photosensitizer; polydopamine; tumor therapy