title: Comparison of sugammadex and neostigmine-atropine on intraocular pressure and postoperative effects.
abstract: During surgery, changes in intraocular pressure (IOP) can be observed resulting from several factors, such as airway manipulations and drugs used. We aimed to investigate the effects of sugammadex and neostigmine on IOP, hemodynamic parameters, and complications after extubation. Our study comprised 60 patients, aged 18-65 years, with a risk status of the American Society of Anesthesiologists I-II who underwent arthroscopic surgery under general anesthesia. The patients were randomly assigned into two groups. At the end of the surgery, the neuromuscular block was reversed using neostigmine (50 μg/kg) plus atropine (15 μg/kg) in Group 1, and sugammadex (4 mg/kg) in Group 2. Neuromuscular blockade was monitored using acceleromyography and a train-of-four mode of stimulation. IOP was measured before induction and at 30 seconds, 2 minutes, and 10 minutes after extubation. A Tono-Pen XL applanation tonometer was used to measure IOP. This showed that elevation in IOP of patients reversed using sugammadex was similar to that recorded in patients reversed using neostigmine-atropine. When heart rate was compared, there was a significant difference between basal values and those obtained at 30 seconds and 10 minutes after extubation in the neostigmine-atropine group. Extubation time (time from withdrawal of anesthetic gas to extubation) was significantly shorter in the sugammadex group (p = 0.003) than in the neostigmine-atropine group. The postextubation IOP values of the sugammadex group were similar to the neostigmine-atropine group. Extubation time (time from withdrawal of anesthetic gas to extubation) was significantly shorter in the sugammadex group (p = 0.003) than in the neostigmine-atropine group.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey. Electronic address: sedathakimoglu@gmail.com.
authors.forename: Sedat
authors.initials: S
authors.lastname: Hakimoğlu
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Kasım
authors.initials: K
authors.lastname: Tuzcu
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Işıl
authors.initials: I
authors.lastname: Davarcı
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Karcıoğlu
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Ayhan Tuzcu
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Hancı
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Suzan
authors.initials: S
authors.lastname: Aydın
authors.affiliation: Department of Ophthalmology, Antakya State Hospital, Antakya, Hatay, Turkey.
authors.forename: Hilal
authors.initials: H
authors.lastname: Kahraman
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Elbeyli
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Turhanoğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001285:Atropine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009388:Neostigmine / Q000008:administration & dosage*; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D009469:Neuromuscular Junction / Q000187:drug effects; D011184:Postoperative Period; D000077122:Sugammadex; D016896:Treatment Outcome; D055815:Young Adult; D047408:gamma-Cyclodextrins / Q000008:administration & dosage*
chemical_list: D009465:Neuromuscular Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D009388:Neostigmine; D001285:Atropine
keywords: Extubation; Intraocular pressure; Neostigmine; Sugammadex