title: PP2A Phosphatase as a Regulator of ROS Signaling in Plants.
abstract: Reactive oxygen species (ROS) carry out vital functions in determining appropriate stress reactions in plants, but the molecular mechanisms underlying the sensing, signaling and response to ROS as signaling molecules are not yet fully understood. Recent studies have underscored the role of Protein Phosphatase 2A (PP2A) in ROS-dependent responses involved in light acclimation and pathogenesis responses in Arabidopsis thaliana. Genetic, proteomic and metabolomic studies have demonstrated that trimeric PP2A phosphatases control metabolic changes and cell death elicited by intracellular and extracellular ROS signals. Associated with this, PP2A subunits contribute to transcriptional and post-translational regulation of pro-oxidant and antioxidant enzymes. This review highlights the emerging role of PP2A phosphatases in the regulatory ROS signaling networks in plants.
authors.affiliation: Department of Biochemistry, Molecular Plant Biology, University of Turku, FI-20014 Turku, Finland. moona.rahikainen@utu.fi.
authors.forename: Moona
authors.initials: M
authors.lastname: Rahikainen
authors.affiliation: Plant Physiology Lab, Organisms and Systems Biology, Faculty of Biology, University of Oviedo, 33006 Oviedo, Spain. pascualjesus@uniovi.es.
authors.forename: Jesús
authors.initials: J
authors.lastname: Pascual
authors.affiliation: Department of Biochemistry, Molecular Plant Biology, University of Turku, FI-20014 Turku, Finland. sara.alegregarcia@utu.fi.
authors.forename: Sara
authors.initials: S
authors.lastname: Alegre
authors.affiliation: Department of Biochemistry, Molecular Plant Biology, University of Turku, FI-20014 Turku, Finland. guido.durian@utu.fi.
authors.forename: Guido
authors.initials: G
authors.lastname: Durian
authors.affiliation: Department of Biochemistry, Molecular Plant Biology, University of Turku, FI-20014 Turku, Finland. saijaliisa.kangasjarvi@utu.fi.
authors.forename: Saijaliisa
authors.initials: S
authors.lastname: Kangasjärvi
keywords: Protein Phosphatase 2A (PP2A); plant; protein phosphorylation; reactive oxygen species (ROS); signaling