title: Septic patients with mitochondrial DNA haplogroup JT have higher respiratory complex IV activity and survival rate.
abstract: The influence of mitochondrial deoxyribonucleic acid (mtDNA) haplogroup or oxidative phosphorylation system (OXPHOS) function on survival of septic patients has been scarcely studied. However, the association between mtDNA haplogroup, OXPHOS capacity at diagnosis of severe sepsis, and survival has been not previously reported, and that was the objective of the present study.
  
  
  
  This was a prospective, multicenter, observational study. Blood samples from 198 patients at diagnosis of severe sepsis were analyzed to determine mtDNA haplogroup and platelet respiratory complex IV (CIV) specific activity. The end point of the study was 30-day survival.
  
  
  
  Septic patients with mtDNA haplogroup JT showed higher 30-day survival than those with mtDNA haplogroup non-JT (31/38 [81.6%] vs 99/160 [61.9%]; P= .02). Septic patients with mtDNA haplogroup JT showed higher platelet CIV specific activity than those with mtDNA haplogroup non-JT (P= .002).
  
  
  
  The main novel finding of our study, including the largest series providing data on platelet CIV specific activity according to mtDNA haplogroup in severe septic patients, was that those with mtDNA haplogroup JT showed higher survival and higher platelet CIV specific activity at diagnosis of severe sepsis than patients with mtDNA haplogroup non-JT.
authors.affiliation: Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n, La Laguna-38320, Santa Cruz de Tenerife, Spain. Electronic address: lorentemartin@msn.com.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Lorente
authors.affiliation: Intensive Care Unit, Hospital Universitario Nuestra Señora Candelaria, Crta Rosario s/n, Santa Cruz Tenerife-38010, Spain. Electronic address: mar.martinvelasco@gmail.com.
authors.forename: María M
authors.initials: MM
authors.lastname: Martín
authors.affiliation: Departamento de Bioquímica y Biología Molecular y Celular, Centro de Investigaciones Biomédicas En Red de Enfermedades Raras (CIBERER) and Instituto de Investigación Sanitaria de Aragón, Universidad de Zaragoza, Zaragoza-50013, Spain. Electronic address: esterlop@unizar.es.
authors.forename: Ester
authors.initials: E
authors.lastname: López-Gallardo
authors.affiliation: Intensive Care Unit, Hospital Clínico Universitario de Valencia, Avda, Blasco Ibáñez n°17-19, Valencia-46004, Spain. Electronic address: blanquer_jos@gva.es.
authors.forename: José
authors.initials: J
authors.lastname: Ferreres
authors.affiliation: Intensive Care Unit, Hospital Universitario Dr. Negrín, Barranco de la Ballena s/n, Las Palmas de Gran Canaria-35010, Spain. Electronic address: jsolvio@gobiernodecanarias.org.
authors.forename: Jordi
authors.initials: J
authors.lastname: Solé-Violán
authors.affiliation: Intensive Care Unit, Hospital San Jorge de Huesca, Avenida Martínez de Velasco n°36, Huesca-22004, Spain. Electronic address: llabarta@salud.aragon.es.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Labarta
authors.affiliation: Intensive Care Unit, Hospital Insular, Plaza Dr. Pasteur s/n, Las Palmas de Gran Canaria-35016, Spain. Electronic address: incaicos@yahoo.es.
authors.forename: César
authors.initials: C
authors.lastname: Díaz
authors.affiliation: Research Unit, Hospital Universitario de Canarias, Ofra, s/n, La Laguna-38320, Santa Cruz de Tenerife, Spain. Electronic address: ajimenezsosa@gmail.com.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Jiménez
authors.affiliation: Departamento de Bioquímica y Biología Molecular y Celular, Centro de Investigaciones Biomédicas En Red de Enfermedades Raras (CIBERER) and Instituto de Investitación Sanitaria de Aragón, Universidad de Zaragoza, Zaragoza-50013, Spain. Electronic address: jmontoya@unizar.es.
authors.forename: Julio
authors.initials: J
authors.lastname: Montoya
authors.affiliation: Departamento de Bioquímica y Biología Molecular y Celular, Centro de Investigaciones Biomédicas En Red de Enfermedades Raras (CIBERER), Instituto de Investitación Sanitaria de Aragón and Fundación ARAID, Universidad de Zaragoza, Zaragoza-50013, Spain. Electronic address: eduruiz@unizar.es.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ruiz-Pesini
mesh_terms: D000368:Aged; D003422:Critical Care; D004272:DNA, Mitochondrial / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D010085:Oxidative Phosphorylation; D011446:Prospective Studies; D018805:Sepsis / Q000235:genetics* / Q000378:metabolism / Q000401:mortality; D013030:Spain; D015996:Survival Rate
chemical_list: D004272:DNA, Mitochondrial; D003576:Electron Transport Complex IV
keywords: Cytochrome c oxidase; Haplogroup; Mitochondrial DNA; Mortality; OXPHOS; Sepsis