title: THE EFFICACY OF THREE MEDICINAL PLANTS: GARLIC, GINGER AND MIRAZID AND A CHEMICAL DRUG METRONIDAZOLE AGAINST CRYPTOSPORIDIUM PARVUM. I-IMMUNOLOGICAL RESPONSE.
abstract: Cryptosporidisis parvum is a zoonotic protozoan parasite infects intestinal epithelial cells causing a major health problem for man and animals. Experimentally the immunologic mediated elimination of C. parvum requires CD4+ T cells and IFN-gamma. But, the innate immune responses also have a significant protective role in both man and animals. the mucosal immune response to C. parvum in C57BL/6 neonatal and GKO mice shows a concomitant Thl and Th2 cytokine mRNA expression, with a crucial role for IFN-gamma in the resolution of the infection. NK cells and IFN-gamma have been shown to be important components in immunity in T and B cell-deficient mice, but IFN-gamma-dependent resistance is demonstrated in alymphocytic mice. Epithelial cells may play a vital role in immunity as once infected these cells have increased expression of inflammatory chemokines and cytokines and demonstrate anti-infection killing mechanisms. C. parvum immunological response was used to evaluate the efficacy of anti-cryptosporidisis agents of Garlic, Ginger, Mirazid and Metronidazole in experimentally infected mice.
authors.forename: Mohamed F
authors.initials: MF
authors.lastname: Abouel-Nour
authors.forename: Dina Magdy M
authors.initials: DM
authors.lastname: EL-Shewehy
authors.forename: Shadia F
authors.initials: SF
authors.lastname: Hamada
authors.forename: Tosson A
authors.initials: TA
authors.lastname: Morsy
mesh_terms: D000818:Animals; D003049:Coccidiostats / Q000737:chemistry / Q000627:therapeutic use*; D029744:Commiphora; D003457:Cryptosporidiosis / Q000188:drug therapy*; D016785:Cryptosporidium parvum / Q000187:drug effects*; D005737:Garlic / Q000737:chemistry; D020939:Zingiber officinale / Q000737:chemistry; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry
chemical_list: D003049:Coccidiostats; D012116:Resins, Plant; D008795:Metronidazole; C587573:myrrh resin