title: Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy.
abstract: Diabetic cardiomyopathy (DCM) is a disorder of the heart muscle in people with diabetes that can occur independent of hypertension or vascular disease. The underlying mechanism of DCM is incompletely understood. Some transcription factors have been suggested to regulate the gene program intricate in the pathogenesis of diabetes prompted cardiac injury. Forkhead box transcription factor 1 is a pleiotropic transcription factor that plays a pivotal role in a variety of physiological processes. Altered FOXO1 expression and function have been associated with cardiovascular diseases, and the important role of FOXO1 in DCM has begun to attract attention. In this review, we focus on the FOXO1 pathway and its role in various processes that have been related to DCM, such as metabolism, oxidative stress, endothelial dysfunction, inflammation and apoptosis.
authors.affiliation: Department of Anesthesiology, The University of Hong Kong, Hong Kong, China. vidyakandula@gmail.com.
authors.forename: Vidya
authors.initials: V
authors.lastname: Kandula
authors.affiliation: Department of Anesthesiology, The University of Hong Kong, Hong Kong, China. kosuru.ramoji@gmail.com.
authors.forename: Ramoji
authors.initials: R
authors.lastname: Kosuru
authors.affiliation: Department of Anesthesiology, The University of Hong Kong, Hong Kong, China. haoboli@connect.hku.hk.
authors.forename: Haobo
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, The University of Hong Kong, Hong Kong, China. danyan1989@163.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Yan
authors.affiliation: Department of Anesthesiology, The University of Hong Kong, Hong Kong, China. qiqizhu_qiqi@163.com.|Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. qiqizhu_qiqi@163.com.
authors.forename: Qiqi
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. lianqingquanmz@163.com.
authors.forename: Qingquan
authors.initials: Q
authors.lastname: Lian
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. r_ge@yahoo.com.
authors.forename: Ren-Shan
authors.initials: RS
authors.lastname: Ge
authors.affiliation: Department of Anesthesiology, The University of Hong Kong, Hong Kong, China. zyxia@hku.hk.|Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. zyxia@hku.hk.
authors.forename: Zhengyuan
authors.initials: Z
authors.lastname: Xia
authors.affiliation: Department of Anesthesiology, The University of Hong Kong, Hong Kong, China. mgirwin@hku.hk.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Irwin
mesh_terms: D000818:Animals; D017209:Apoptosis; D058065:Diabetic Cardiomyopathies / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress; D015398:Signal Transduction
chemical_list: C085126:FOXO1 protein, human; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D018836:Inflammation Mediators