title: Epstein-Barr virus hemorrhagic meningoencephalitis: case report and review of the literature.
abstract: Neurologic complications related to Epstein-Barr virus (EBV) in immunocompetent adults are rare and most commonly self-limited. However, severe cases have been previously reported in the literature. We describe a case of meningoencephalitis with frontal bilateral hemorrhage in a non-immunocompromised adult following an EBV infection of the central nervous system confirmed by the presence of EBV-DNA in the cerebrospinal fluid. During the patient's hospital stay, there was a favorable clinical and radiologic evolution and the patient was discharged asymptomatic. To our knowledge, this is the fourth case of hemorrhagic meningoencephalitis related to EBV and the first one in an immunocompetent patient with a favorable outcome.
authors.affiliation: Centro Hospitalar de Setúbal, Setubal, Portugal. biancafilipebranco@gmail.com.
authors.forename: Bianca Branco
authors.initials: BB
authors.lastname: Ascenção
authors.affiliation: Centro Hospitalar de Setúbal, Setubal, Portugal.
authors.forename: Ana Catarina
authors.initials: AC
authors.lastname: Gonçalves
authors.affiliation: Centro Hospitalar de Setúbal, Setubal, Portugal.
authors.forename: Nuno
authors.initials: N
authors.lastname: Luís
authors.affiliation: Centro Hospitalar de Setúbal, Setubal, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Sá
authors.affiliation: Centro Hospitalar de Setúbal, Setubal, Portugal.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Brito
authors.affiliation: Centro Hospitalar de Setúbal, Setubal, Portugal.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Poças
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007121:Immunocompetence; D008279:Magnetic Resonance Imaging; D008297:Male; D008590:Meningoencephalitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D008875:Middle Aged; D059906:Neuroimaging; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000998:Antiviral Agents; D000212:Acyclovir
keywords: EBV; Hemorrhage; Meningoencephalitis