title: Sustained Effectiveness of Monovalent and Pentavalent Rotavirus Vaccines in Children.
abstract: Using case-control methodology, we measured the vaccine effectiveness (VE) of the 2-dose monovalent rotavirus vaccine (RV1) and 3-dose pentavalent rotavirus vaccine (RV5) series given in infancy against rotavirus disease resulting in hospital emergency department or inpatient care.
  
  
  
  Children were eligible for enrollment if they presented to any 1 of 3 hospitals in Atlanta, Georgia with diarrhea ≤10 days duration during January-June 2013 and were born after RV1 introduction. Stool samples were tested for rotavirus by enzyme immunoassay and immunization records were obtained from providers and the state electronic immunization information system. Case-subjects (children testing rotavirus antigen-positive) were compared with children testing rotavirus antigen-negative.
  
  
  
  Overall, 98 rotavirus-case subjects and 175 rotavirus-negative controls were enrolled. Genotype G12P[8] predominated (n = 87, 89%). The VE of 2 RV1 doses was 84% (95% CI 38, 96) among children aged 8-23 months and 82% (95% CI 41, 95) among children aged ≥24 months. For the same age groups, the VE of 3 RV5 doses was 80% (95% CI 27, 95) and 87% (95% CI 22, 98), respectively.
  
  
  
  Under routine use, the RV1 and RV5 series were both effective against moderate-to-severe rotavirus disease during a G12P[8] season, and both vaccines demonstrated sustained protection beyond the first 2 years of life.
authors.affiliation: Departments of Microbiology, Biochemistry, Immunology, and Pediatrics, Morehouse School of Medicine, Atlanta, GA; Clinical Research Center, Morehouse School of Medicine, Atlanta, GA; Children's Healthcare of Atlanta, Atlanta, GA. Electronic address: limmergluck@msm.edu.
authors.forename: Lilly Cheng
authors.initials: LC
authors.lastname: Immergluck
authors.affiliation: Departments of Microbiology, Biochemistry, Immunology, and Pediatrics, Morehouse School of Medicine, Atlanta, GA; Clinical Research Center, Morehouse School of Medicine, Atlanta, GA.
authors.forename: Trisha Chan
authors.initials: TC
authors.lastname: Parker
authors.affiliation: Children's Healthcare of Atlanta, Atlanta, GA; Department of Pediatrics, Emory University, Atlanta, GA.
authors.forename: Shabnam
authors.initials: S
authors.lastname: Jain
authors.affiliation: Departments of Microbiology, Biochemistry, Immunology, and Pediatrics, Morehouse School of Medicine, Atlanta, GA; Clinical Research Center, Morehouse School of Medicine, Atlanta, GA.
authors.forename: Elham
authors.initials: E
authors.lastname: Laghaie
authors.affiliation: Pediatric Emergency Medicine Associates, Atlanta, GA.
authors.forename: Philip
authors.initials: P
authors.lastname: Spandorfer
authors.affiliation: Children's Healthcare of Atlanta, Atlanta, GA; Department of Pathology, Emory University, Atlanta, GA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Jerris
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Bowen
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Cortese
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000821:virology*; D005845:Georgia; D006801:Humans; D007223:Infant; D008297:Male; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage*
chemical_list: D022243:Rotavirus Vaccines