title: Systemic hypertension and diabetes mellitus as predictors of malignancy among women with endometrial polyps: a meta-analysis of observational studies.
abstract: Diabetes mellitus (DM) and systemic hypertension (SH) are frequent benign diseases which might coexist with endometrial polyps. We sought to evaluate whether women who suffer from these diseases have an increased incidence of premalignant and malignant lesions.
  
  
  
  We systematically searched the literature using the Medline (by using Pubmed) (1966-2015), Scopus (2004-2015), ClinicalTrials.gov (2008-2015), Cochrane Central Register (CENTRAL), and Google Scholar (2004-2015) databases along with the references of all articles which were retrieved in full text. We performed the meta-analysis with the RevMan 5.1 software.
  
  
  
  Both DM and SH seem to be correlated with increased odds of developing premalignant and malignant endometrial polyps (odds ratio 2.43, 95% confidence interval 1.51, 3.91) and (odds ratio 2.36, 95% confidence interval 1.16, 4.81). However, it remains unclear whether type I or type II DM exert a more pronounced effect and whether the severity of SH has an impact on these odds. Also, the potential relation of antidiabetic and antihypertensive treatment with these lesions cannot be excluded.
  
  
  
  Physicians should increase their awareness among women with endometrial polyps who suffer from DM and/or SH. Further studies are needed to corroborate our findings and elucidate the underlying mechanisms of this relation.
authors.affiliation: 1Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Athens, Greece 2First dpt of Ob/Gyn, Division of Gynecologic Oncology, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Vasilios
authors.initials: V
authors.lastname: Pergialiotis
authors.forename: Anastasia
authors.initials: A
authors.lastname: Prodromidou
authors.forename: Charalampos
authors.initials: C
authors.lastname: Siotos
authors.forename: Maximos
authors.initials: M
authors.lastname: Frountzas
authors.forename: Despina
authors.initials: D
authors.lastname: Perrea
authors.forename: Georgios D
authors.initials: GD
authors.lastname: Vlachos
mesh_terms: D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000453:epidemiology*; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology*; D016239:MEDLINE; D016017:Odds Ratio; D011127:Polyps / Q000453:epidemiology*; D011230:Precancerous Conditions / Q000453:epidemiology; D012307:Risk Factors