title: One-Pot Trimetallic Relay Catalysis: A Unified Approach for the Synthesis of β-Carbolines and Other [c]-Fused Pyridines.
abstract: A divergent strategy is presented for the synthesis of 1,3-di- and 1,3,4-trisubstituted β-carbolines through an unprecedented one-pot triple-orthogonal-metal relay catalysis, and 1,3-disubstituted 4-hydroxy-β-carbolines through a one-pot bimetallic relay catalysis from readily accessible 3-(2-aminophenyl)-5-hexenyn-3-ols. These strategies were elaborated to enable the synthesis of benzofuro[2,3-c]pyridines, benzothieno[2,3-c]pyridines, and isoquinolines, which otherwise require multistep synthesis.
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, Sector 81, S. A. S., Nagar, Manuali PO, Punjab, 140306, India.
authors.forename: Seema
authors.identifier: 0000-0002-0897-9925
authors.initials: S
authors.lastname: Dhiman
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, Sector 81, S. A. S., Nagar, Manuali PO, Punjab, 140306, India.
authors.forename: Uttam K
authors.identifier: 0000-0003-3670-7107
authors.initials: UK
authors.lastname: Mishra
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, Sector 81, S. A. S., Nagar, Manuali PO, Punjab, 140306, India. ramsastry@iisermohali.ac.in, ramsastrys@gmail.com.
authors.forename: S S V
authors.identifier: 0000-0001-5814-9092
authors.initials: SS
authors.lastname: Ramasastry
keywords: Lewis acids; azides; relay catalysis; transition metals; β-carbolines