title: Automated pericardial fat quantification from coronary magnetic resonance angiography: feasibility study.
abstract: Pericardial fat volume (PFV) is emerging as an important parameter for cardiovascular risk stratification. We propose a hybrid approach for automated PFV quantification from water/fat-resolved whole-heart noncontrast coronary magnetic resonance angiography (MRA). Ten coronary MRA datasets were acquired. Image reconstruction and phase-based water-fat separation were conducted offline. Our proposed algorithm first roughly segments the heart region on the original image using a simplified atlas-based segmentation with four cases in the atlas. To get exact boundaries of pericardial fat, a three-dimensional graph-based segmentation is used to generate fat and nonfat components on the fat-only image. The algorithm then selects the components that represent pericardial fat. We validated the quantification results on the remaining six subjects and compared them with manual quantifications by an expert reader. The PFV quantified by our algorithm was [Formula: see text], compared to [Formula: see text] by the expert reader, which were not significantly different ([Formula: see text]) and showed excellent correlation ([Formula: see text],[Formula: see text]). The mean absolute difference in PFV between the algorithm and the expert reader was [Formula: see text]. The mean value of the paired differences was [Formula: see text] (95% confidence interval: [Formula: see text] to 6.21). The mean Dice coefficient of pericardial fat voxels was [Formula: see text]. Our approach may potentially be applied in a clinical setting, allowing for accurate magnetic resonance imaging (MRI)-based PFV quantification without tedious manual tracing.
authors.affiliation: Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, Department of Biomedical Sciences, 8700 Beverly Boulevard, Los Angeles, California 90048, United States; University of California-Los Angeles, Computer Science Department, Computer Graphics & Vision Laboratory, 580 Portola Plaza, Los Angeles, California 90095, United States.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Ding
authors.affiliation: Cedars-Sinai Medical Center , Biomedical Imaging Research Institute, Department of Biomedical Sciences, 8700 Beverly Boulevard, Los Angeles, California 90048, United States.
authors.forename: Jianing
authors.initials: J
authors.lastname: Pang
authors.affiliation: University of California-Los Angeles , Computer Science Department, Computer Graphics & Vision Laboratory, 580 Portola Plaza, Los Angeles, California 90095, United States.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Ren
authors.affiliation: Cedars-Sinai Medical Center , Departments of Imaging and Medicine, 8700 Beverly Boulevard, Los Angeles, California 90048, United States.
authors.forename: Mariana
authors.initials: M
authors.lastname: Diaz-Zamudio
authors.affiliation: University of California-Los Angeles , Computer Science Department, Computer Graphics & Vision Laboratory, 580 Portola Plaza, Los Angeles, California 90095, United States.
authors.forename: Chenfanfu
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Cedars-Sinai Medical Center , Biomedical Imaging Research Institute, Department of Biomedical Sciences, 8700 Beverly Boulevard, Los Angeles, California 90048, United States.
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Fan
authors.affiliation: Cedars-Sinai Medical Center, Departments of Imaging and Medicine, 8700 Beverly Boulevard, Los Angeles, California 90048, United States; University of California-Los Angeles, Department of Medicine, David-Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, California 90095, United States.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Berman
authors.affiliation: Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, Department of Biomedical Sciences, 8700 Beverly Boulevard, Los Angeles, California 90048, United States; University of California-Los Angeles, Department of Medicine, David-Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, California 90095, United States.
authors.forename: Debiao
authors.initials: D
authors.lastname: Li
authors.affiliation: University of California-Los Angeles , Computer Science Department, Computer Graphics & Vision Laboratory, 580 Portola Plaza, Los Angeles, California 90095, United States.
authors.forename: Demetri
authors.initials: D
authors.lastname: Terzopoulos
authors.affiliation: Cedars-Sinai Medical Center, Departments of Imaging and Medicine, 8700 Beverly Boulevard, Los Angeles, California 90048, United States; University of California-Los Angeles, Department of Medicine, David-Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, California 90095, United States.
authors.forename: Piotr J
authors.initials: PJ
authors.lastname: Slomka
authors.affiliation: Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, Department of Biomedical Sciences, 8700 Beverly Boulevard, Los Angeles, California 90048, United States; University of California-Los Angeles, Department of Medicine, David-Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, California 90095, United States.
authors.forename: Damini
authors.initials: D
authors.lastname: Dey
keywords: atlas; coronary magnetic resonance angiography; graph model; pericardial fat; segmentation