title: Cytokine therapy restores antitumor responses of NK cells rendered anergic in MHC I-deficient tumors.
abstract: Recent extraordinary advances in cancer immunotherapy rely primarily on marshaling T cell responses. Here we discuss how NK cell responses can be amplified. We find that MHC I-deficient tumors induce anergy of NK cells but that cytokine therapy restores NK cell activity and increases the survival of mice bearing MHC I-deficient tumors.
authors.affiliation: Department of Molecular and Cell Biology, and Cancer Research Laboratory; Division of Immunology and Pathogenesis; Department of Molecular and Cell Biology; University of California, Berkeley ; Berkeley, CA USA.
authors.forename: Michele
authors.initials: M
authors.lastname: Ardolino
authors.affiliation: Department of Molecular and Cell Biology, and Cancer Research Laboratory; Division of Immunology and Pathogenesis; Department of Molecular and Cell Biology; University of California, Berkeley ; Berkeley, CA USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Raulet
keywords: NK cells; cancer immunotherapy; cytokines