title: Evaluation of choroidal thickness in psoriasis using optical coherence tomography.
abstract: The purpose of this study was to evaluate choroidal thickness (CT) in patients with psoriasis using enhanced depth imaging optical coherence tomography (EDI-OCT) and to determine its relationship with psoriasis activity indices. In this prospective study, EDI-OCT images were obtained in consecutive patients with psoriasis and in age-gender-matched healthy individuals. Comprehensive ophthalmic examination and EDI-OCT evaluation were performed. CT was measured in the subfoveal area. Correlation analyses were performed to identify the relationship of the CT with disease duration and clinical disease activity score. In total, 65 individuals were evaluated in this study, 35 with psoriasis and 30 controls. The mean disease duration of the patients with psoriasis was 15.7 ± 8.8 years (0.3-34 years). There was no difference between groups with respect to age and gender (p = 0.695 and p = 0.628, respectively). Five of the 35 patients with psoriasis had anterior uveitis. None of the patients with psoriasis had signs of posterior uveitis. CT was significantly higher in the psoriasis group than that of control subjects (p < 0.001). The mean central foveal thickness was comparable between groups (p = 0.672). There was also no significant correlation between EDI-OCT, disease activity score, and disease duration (p < 0.05). Choroidal thickness is increased in psoriasis patients. Large serial and comparative studies are necessary to evaluate EDI-OCT, an examination that may be helpful in understanding the effects of psoriasis on the eye and its pathophysiology.
authors.affiliation: Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey. turkcufm@gmail.com.
authors.forename: Fatih Mehmet
authors.initials: FM
authors.lastname: Türkcü
authors.affiliation: Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey.
authors.forename: Alparslan
authors.initials: A
authors.lastname: Şahin
authors.affiliation: Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Yüksel
authors.affiliation: Department of Dermatology, Dicle University Faculty of Medicine, Diyarbakir, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Akkurt
authors.affiliation: Department of Dermatology, Dicle University Faculty of Medicine, Diyarbakir, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Uçmak
authors.affiliation: Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Çınar
authors.affiliation: Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey.
authors.forename: Adnan
authors.initials: A
authors.lastname: Yıldırım
authors.affiliation: Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey.
authors.forename: İhsan
authors.initials: İ
authors.lastname: Çaça
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002829:Choroid / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011565:Psoriasis / Q000473:pathology*; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods; D014605:Uveitis / Q000473:pathology; D014792:Visual Acuity; D055815:Young Adult
keywords: Choroidal thickness; Psoriasis; Uveitis