title: Single-Nucleotide Polymorphisms of IL-17 Gene Are Associated with Asthma Susceptibility in an Asian Population.
abstract: BACKGROUND
  The aim of this study was to examine the associations between the single-nucleotide polymorphisms (SNPs) of interleukin-17 (IL-17), including rs763780 (7488A/G), rs2275913 (-197G/A), and rs8193036 (-737C/T), and asthma susceptibility in an Asian population.
  
  
  METHODS
  From Oct 2013 to Dec 2014, 125 asthma patients enrolled in our hospital were selected as the case group. Another 132 healthy controls undergoing physical examinations in our hospital were enrolled as the control group. The genotype frequencies of IL-17 rs763780, rs2275913 and rs8193036 SNPs were detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Comprehensive Meta-analysis 2.0 (CMA 2.0) software was applied for meta-analysis.
  
  
  RESULTS
  Our results demonstrated that asthma patients presented with higher frequencies of GA genotype in rs2275913 and TT genotype in rs8193036 of IL-17 than healthy controls (both P<0.001). The genotype frequencies of IL-17 rs763780 between the asthma patients and healthy controls exhibited no significant differences (P>0.05). The comparisons on the rs2275913 and rs8193036 frequencies between the asthma patients and healthy controls were statistically significant in both allele and addictive models (all P<0.05). The frequency of IL-17 rs763780 between the asthma patients and healthy controls were statistically different in allele models (P<0.05), but not in addictive models (P>0.05). The overall results of our case-control study were further confirmed by meta-analysis.
  
  
  CONCLUSIONS
  Our results revealed that, in an Asian population, IL-17 rs763780, rs2275913, and rs8193036 SNPs may be associated with asthma susceptibility, and GA genotype in rs2275913 and TT genotype in rs8193036 of IL-17 may contribute to increased risk of asthma in Asians.
authors.affiliation: Department of Respiratory Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan, China (mainland).
authors.forename: Jin
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Respiratory Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan, China (mainland).
authors.forename: Ji-Chang
authors.initials: JC
authors.lastname: Han
authors.affiliation: Department of Respiratory Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan, China (mainland).
authors.forename: Ya-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan, China (mainland).
authors.forename: Guan-Bin
authors.initials: GB
authors.lastname: Qi
authors.affiliation: Department of Respiratory Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan, China (mainland).
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan, China (mainland).
authors.forename: Yi-Jie
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan, China (mainland).
authors.forename: Shao
authors.initials: S
authors.lastname: Cai
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D001249:Asthma / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17