title: Polarity and asymmetric cell division in the control of lymphocyte fate decisions and function.
abstract: Polarity is important in several lymphocyte processes including lymphocyte migration, formation of the immunological synapse, and asymmetric cell division (ACD). While lymphocyte migration and immunological synapse formation are relatively well understood, the role of lymphocyte ACD is less clear. Recent advances in measuring polarity enable more robust analyses of asymmetric cell division. Use of these new methods has produced crucial quantification of ACD at precise phases of lymphocyte development and activation. These developments are leading to a better understanding of the drivers of fate choice during lymphocyte activation and provide a context within which to explain the effects of ACD.
authors.affiliation: Immune Signalling Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia; Centre for Micro-Photonics, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Australia; Department of Pathology, The University of Melbourne, Australia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Yassin
authors.affiliation: Immune Signalling Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia; Centre for Micro-Photonics, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Australia; Department of Pathology, The University of Melbourne, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Australia. Electronic address: sarah.russell@petermac.org.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Russell
mesh_terms: D000818:Animals; D060049:Asymmetric Cell Division / Q000502:physiology*; D002450:Cell Communication; D016764:Cell Polarity / Q000502:physiology*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000502:physiology*; D015398:Signal Transduction