title: Rates of major bleeding with rivaroxaban in real-world studies of nonvalvular atrial fibrillation patients: a meta-analysis.
abstract: Numerous real-world studies estimating major bleeding rates in rivaroxaban patients with nonvalvular atrial fibrillation have been published. We performed a meta-analysis to better quantify the rates of different types of major bleeding seen with rivaroxaban in observational studies. The pooled rates of major bleeding with rivaroxaban were generally low and consistent with those reported in its pivotal randomized controlled trial.
authors.affiliation: a University of Connecticut School of Pharmacy , Storrs , CT , USA ;
authors.forename: Erin R
authors.initials: ER
authors.lastname: Weeda
authors.affiliation: a University of Connecticut School of Pharmacy , Storrs , CT , USA ;
authors.forename: C Michael
authors.initials: CM
authors.lastname: White
authors.affiliation: b Department of Emergency Medicine , Baylor College of Medicine , Houston , TX , USA.
authors.forename: W Frank
authors.initials: WF
authors.lastname: Peacock
authors.affiliation: a University of Connecticut School of Pharmacy , Storrs , CT , USA ;
authors.forename: Craig I
authors.initials: CI
authors.lastname: Coleman
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy*; D006470:Hemorrhage / Q000139:chemically induced / Q000453:epidemiology*; D006801:Humans; D000069552:Rivaroxaban / Q000627:therapeutic use*; D020521:Stroke / Q000188:drug therapy / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D000069552:Rivaroxaban
keywords: Major bleeding; Meta-analysis; Nonvalvular atrial fibrillation; Rivaroxaban