title: Mortality Prediction in ICUs Using A Novel Time-Slicing Cox Regression Method.
abstract: Over the last few decades, machine learning and data mining have been increasingly used for clinical prediction in ICUs. However, there is still a huge gap in making full use of the time-series data generated from ICUs. Aiming at filling this gap, we propose a novel approach entitled Time Slicing Cox regression (TS-Cox), which extends the classical Cox regression into a classification method on multi-dimensional time-series. Unlike traditional classifiers such as logistic regression and support vector machines, our model not only incorporates the discriminative features derived from the time-series, but also naturally exploits the temporal orders of these features based on a Cox-like function. Empirical evaluation on MIMIC-II database demonstrates the efficacy of the TS-Cox model. Our TS-Cox model outperforms all other baseline models by a good margin in terms of AUC_PR, sensitivity and PPV, which indicates that TS-Cox may be a promising tool for mortality prediction in ICUs.
authors.affiliation: Department of Computer Science and Engineering, Washington University, St. Louis, MO.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Computer Science and Engineering, Washington University, St. Louis, MO.
authors.forename: Wenlin
authors.initials: W
authors.lastname: Chen
authors.affiliation: School of Medicine, Washington University, St. Louis, MO.
authors.forename: Kevin
authors.initials: K
authors.lastname: Heard
authors.affiliation: School of Medicine, Washington University, St. Louis, MO.
authors.forename: Marin H
authors.initials: MH
authors.lastname: Kollef
authors.affiliation: School of Medicine, Washington University, St. Louis, MO.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Bailey
authors.affiliation: Department of Computer Science and Engineering, Washington University, St. Louis, MO.
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Cui
authors.affiliation: Department of Computer Science and Engineering, Washington University, St. Louis, MO.
authors.forename: Yujie
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Computer Science and Engineering, Washington University, St. Louis, MO.
authors.forename: Chenyang
authors.initials: C
authors.lastname: Lu
authors.affiliation: Department of Computer Science and Engineering, Washington University, St. Louis, MO.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Chen
mesh_terms: D057225:Data Mining; D016208:Databases, Factual; D006801:Humans; D007362:Intensive Care Units; D012044:Regression Analysis; D060388:Support Vector Machine