title: Spontaneous Age-related Lesions of the Kidney Fornices in Sprague-Dawley Rats.
abstract: The upper portion of the rat kidney pelvis has specialized anatomic structures referred to as fornices. Fornices have a role in urine concentration. Spontaneous lesions including mineralization, epithelial hyperplasia, and inflammatory cell infiltration may occur in the area of the fornices. However, little information regarding specific historical control data or the spontaneous development of these findings in male and female fornices is known. Understanding spontaneous age-related lesions in the area of the fornices versus other portions of the kidney pelvis may be relevant in the identification of test article-induced changes. A retrospective study was conducted of male and female Sprague-Dawley rat kidney fornices over several time points to determine the incidence and severity of mineralization, epithelial hyperplasia, and inflammatory cell infiltration. Based on this investigation, these lesions appeared to increase over time and, in general, occurred earlier and with a greater incidence in females. Regarding those chemicals that may result in lesions of the kidney pelvis, it may be important for pathologists to separately diagnose lesions of the fornices from other portions of the kidney pelvis to help differentiate between any spontaneous age-related and induced changes.
authors.affiliation: LSI Medience Corporation, Kamisu, Ibaraki, Japan tomonari.yuki@mb.medience.co.jp.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Tomonari
authors.affiliation: LSI Medience Corporation, Kamisu, Ibaraki, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kurotaki
authors.affiliation: LSI Medience Corporation, Kamisu, Ibaraki, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Sato
authors.affiliation: LSI Medience Corporation, Kamisu, Ibaraki, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Doi
authors.affiliation: LSI Medience Corporation, Kamisu, Ibaraki, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kokoshima
authors.affiliation: LSI Medience Corporation, Kamisu, Ibaraki, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kanno
authors.affiliation: LSI Medience Corporation, Kamisu, Ibaraki, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Tsuchitani
authors.affiliation: Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, USA.
authors.forename: John Curtis
authors.initials: JC
authors.lastname: Seely
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D004032:Diet; D005260:Female; D006651:Histocytochemistry; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012189:Retrospective Studies
keywords: fornices; histology; kidney; pathology; rat