title: Anti-virulence Strategies to Target Bacterial Infections.
abstract: Resistance of important bacterial pathogens to common antimicrobial therapies and the emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute one of our greatest challenges in the combat of bacterial infection and accompanied diseases. The current shortage of effective drugs, lack of successful prevention measures and only a few new antibiotics in the clinical pipeline demand the development of novel treatment options and alternative antimicrobial therapies. Our increasing understanding of bacterial virulence strategies and the induced molecular pathways of the infectious disease provides novel opportunities to target and interfere with crucial pathogenicity factors or virulence-associated traits of the bacteria while bypassing the evolutionary pressure on the bacterium to develop resistance. In the past decade, numerous new bacterial targets for anti-virulence therapies have been identified, and structure-based tailoring of intervention strategies and screening assays for small-molecule inhibitors of such pathways were successfully established. In this chapter, we will take a closer look at the bacterial virulence-related factors and processes that present promising targets for anti-virulence therapies, recently discovered inhibitory substances and their promises and discuss the challenges, and problems that have to be faced.
authors.affiliation: Helmholtz-Zentrum für Infektionsforschung and Deutsches Zentrum für Infektionsforschung, Inhoffenstr. 7, 38124, Brunswick, Germany.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Mühlen
authors.affiliation: Helmholtz-Zentrum für Infektionsforschung and Deutsches Zentrum für Infektionsforschung, Inhoffenstr. 7, 38124, Brunswick, Germany. petra.dersch@helmholtz-hzi.de.
authors.forename: Petra
authors.initials: P
authors.lastname: Dersch
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D014774:Virulence / Q000187:drug effects; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D037521:Virulence Factors