title: Reduced Myelin Water in the White Matter Tracts of Patients with Niemann-Pick Disease Type C.
abstract: Previous studies using diffusion tensor imaging to examine white matter in Niemann-Pick disease type C have produced mixed results. However, diffusion tensor imaging does not directly measure myelin and may be affected by other structural changes. We used myelin water imaging to more directly examine demyelination in 2 patients with Niemann-Pick disease type C. The results suggest that this technique may be useful for identifying regional changes in myelination in this condition.
authors.affiliation: From the Crossmodal Perception and Plasticity Laboratory (J.D.-T.), Center of Mind/Brain Sciences, University of Trento, Trento, Italy Human Vision and Eye Movement Laboratory (J.D.-T., J.J.S.B.) Jodie.DaviesThompson@unitn.it.
authors.forename: J
authors.identifier: 0000-0002-9355-4306
authors.initials: J
authors.lastname: Davies-Thompson
authors.affiliation: Departments of Medicine (Neurology), Ophthalmology, and Visual Sciences, Department of Radiology (I.V.).
authors.forename: I
authors.identifier: 0000-0001-9286-0953
authors.initials: I
authors.lastname: Vavasour
authors.affiliation: Department of Radiology (M.S.), Charité University Clinics, Berlin, Germany.
authors.forename: M
authors.identifier: 0000-0002-3505-2914
authors.initials: M
authors.lastname: Scheel
authors.affiliation: Department of Pediatrics, and UBC MRI Research Centre (A.R.), University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: A
authors.identifier: 0000-0002-1961-8252
authors.initials: A
authors.lastname: Rauscher
authors.affiliation: Human Vision and Eye Movement Laboratory (J.D.-T., J.J.S.B.).
authors.forename: J J S
authors.identifier: 0000-0001-8264-3795
authors.initials: JJ
authors.lastname: Barton
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D009186:Myelin Sheath / Q000737:chemistry / Q000473:pathology*; D059906:Neuroimaging / Q000379:methods*; D052556:Niemann-Pick Disease, Type C / Q000000981:diagnostic imaging* / Q000473:pathology; D014867:Water / Q000032:analysis; D066127:White Matter / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D014867:Water