title: Biomaterials with Antibacterial and Osteoinductive Properties to Repair Infected Bone Defects.
abstract: The repair of infected bone defects is still challenging in the fields of orthopedics, oral implantology and maxillofacial surgery. In these cases, the self-healing capacity of bone tissue can be significantly compromised by the large size of bone defects and the potential/active bacterial activity. Infected bone defects are conventionally treated by a systemic/local administration of antibiotics to control infection and a subsequent implantation of bone grafts, such as autografts and allografts. However, these treatment options are time-consuming and usually yield less optimal efficacy. To approach these problems, novel biomaterials with both antibacterial and osteoinductive properties have been developed. The antibacterial property can be conferred by antibiotics and other novel antibacterial biomaterials, such as silver nanoparticles. Bone morphogenetic proteins are used to functionalize the biomaterials with a potent osteoinductive property. By manipulating the carrying modes and release kinetics, these biomaterials are optimized to maximize their antibacterial and osteoinductive functions with minimized cytotoxicity. The findings, in the past decade, have shown a very promising application potential of the novel biomaterials with the dual functions in treating infected bone defects. In this review, we will summarize the current knowledge of novel biomaterials with both antibacterial and osteoinductive properties.
authors.affiliation: School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China. noprint2000@hotmail.com.
authors.forename: Haiping
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Oral Implantology and Prosthetic Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute, Amsterdam 1081LA, The Netherlands. liuyizzd@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China. tracyguo1218@hotmail.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.affiliation: The First Affiliated Hospital, Medical School, Zhejiang University, Hangzhou 310003, China. whl1616@126.com.
authors.forename: Huiling
authors.initials: H
authors.lastname: Wu
authors.affiliation: The First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China. wangjingxiao@zju.edu.cn.
authors.forename: Jingxiao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Oral Implantology and Prosthetic Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute, Amsterdam 1081LA, The Netherlands. g.wu@acta.nl.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects / Q000293:injuries / Q000382:microbiology / Q000503:physiopathology; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins
keywords: antibacterial; antibiotics; bone morphogenetic protein2 (BMP2); bone regeneration; co-delivery; infected bone defect; osteoinductive