title: Inhibition of Morganella morganii Histidine Decarboxylase Activity and Histamine Accumulation in Mackerel Muscle Derived from Filipendula ulumaria Extracts.
abstract: Filipendula ulmaria, also known as meadowsweet, is an herb; its extract was examined for the prevention of histamine production, primarily that caused by contaminated fish. The efficacy of meadowsweet was assessed using two parameters: inhibition of Morganella morganii histidine decarboxylase (HDC) and inhibition of histamine accumulation in mackerel. Ellagitannins from F. ulmaria (rugosin D, rugosin A methyl ester, tellimagrandin II, and rugosin A) were previously shown to be potent inhibitors of human HDC; and in the present work, these compounds inhibited M. morganii HDC, with half maximal inhibitory concentration values of 1.5, 4.4, 6.1, and 6.8 μM, respectively. Application of the extracts (at 2 wt%) to mackerel meat yielded significantly decreased histamine accumulation compared with treatment with phosphate-buffered saline as a control. Hence, F. ulmaria exhibits inhibitory activity against bacterial HDC and might be effective for preventing food poisoning caused by histamine.
authors.affiliation: Department of Nutritional Science, Okayama Prefectural University, Okayama 719-1197, Japan. nitta@fhw.oka-pu.ac.jp.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nitta
authors.affiliation: School of Human Science and Environment, University of Hyogo, Hyogo 670-0092, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Yasukata
authors.affiliation: School of Human Science and Environment, University of Hyogo, Hyogo 670-0092, Japan.
authors.forename: Noritoshi
authors.initials: N
authors.lastname: Kitamoto
authors.affiliation: School of Human Science and Environment, University of Hyogo, Hyogo 670-0092, Japan.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Ito
authors.affiliation: School of Human Science and Environment, University of Hyogo, Hyogo 670-0092, Japan.
authors.forename: Motoyoshi
authors.initials: M
authors.lastname: Sakaue
authors.affiliation: Department of Food Science and Nutrition, Nara Women's University, Nara 630-8506, Japan.
authors.forename: Hiroe
authors.initials: H
authors.lastname: Kikuzaki
authors.affiliation: Laboratory of Applied Microbiology and Biochemistry, School of Agriculture, Ryukoku University, Shiga 520-2194, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueno
mesh_terms: D000818:Animals; D031984:Filipendula / Q000737:chemistry*; D005506:Food Contamination / Q000517:prevention & control; D005516:Food Microbiology; D005517:Foodborne Diseases / Q000517:prevention & control; D006632:Histamine / Q000378:metabolism*; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D047348:Hydrolyzable Tannins / Q000494:pharmacology; D020613:Morganella morganii / Q000187:drug effects* / Q000201:enzymology; D010473:Perciformes / Q000382:microbiology*; D010936:Plant Extracts / Q000494:pharmacology; D017747:Seafood / Q000382:microbiology*
chemical_list: D047348:Hydrolyzable Tannins; D010936:Plant Extracts; D006632:Histamine; D006640:Histidine Decarboxylase