title: [Chronic nonbacterial osteomyelitis].
abstract: Chronic nonbacterial osteomyelitis is an autoinflammatory disease occurring mainly in children and adolescents, typically involving recurrent or persistent osteitic foci. The symptom is bone pain, possibly accompanied by soft tissue tenderness. Some patients exhibit symptoms of systemic inflammation. The. precise etiology of the disease is not known, but an imbalance of inflammatory and anti-inflammatory cytokines is presumed to play a role in the development of the disease. While an anti-inflammatory analgesic is in most cases sufficient to calm down the osteitis, the use of corticosteroids, anti- TNF-a inhibitors or bisphosphonates is required in some cases.
authors.forename: Paula
authors.initials: P
authors.lastname: Keskitalo
authors.forename: Terhi
authors.initials: T
authors.lastname: Remes-Pakarinen
authors.forename: Paula
authors.initials: P
authors.lastname: Vähäsalo
authors.forename: Jaakko
authors.initials: J
authors.lastname: Niinimäki
authors.forename: Liisa
authors.initials: L
authors.lastname: Kröger
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002908:Chronic Disease; D016207:Cytokines / Q000276:immunology; D003937:Diagnosis, Differential; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D010019:Osteomyelitis / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D016207:Cytokines; D004164:Diphosphonates; D014409:Tumor Necrosis Factor-alpha