title: Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis.
abstract: Helicobacter pylori is the dominant member of the gastric microbiota in over half of the human population of which 5-15% develop gastritis or gastric malignancies. Immune responses to H. pylori are characterized by mixed T helper cell, cytotoxic T cell and NK cell responses. The presence of Tregs is essential for the control of gastritis and together with regulatory CX3CR1+ mononuclear phagocytes and immune-evasion strategies they enable life-long persistence of H. pylori. This H. pylori-induced regulatory environment might contribute to its cross-protective effect in inflammatory bowel disease and obesity. Here we review host-microbe interactions, the development of pro- and anti-inflammatory immune responses and how the latter contribute to H. pylori's role as beneficial member of the gut microbiota. Furthermore, we present the integration of existing and new data into a computational/mathematical model and its use for the investigation of immunological mechanisms underlying initiation, progression and outcomes of H. pylori infection.
authors.affiliation: a Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens; Virginia Bioinformatics Institute; Virginia Tech ; Blacksburg , VA , USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kronsteiner
authors.affiliation: a Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens; Virginia Bioinformatics Institute; Virginia Tech ; Blacksburg , VA , USA.
authors.forename: Josep
authors.initials: J
authors.lastname: Bassaganya-Riera
authors.affiliation: b BioTherapeutics ; Blacksburg , VA , USA.
authors.forename: Casandra
authors.initials: C
authors.lastname: Philipson
authors.affiliation: a Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens; Virginia Bioinformatics Institute; Virginia Tech ; Blacksburg , VA , USA.
authors.forename: Monica
authors.initials: M
authors.lastname: Viladomiu
authors.affiliation: b BioTherapeutics ; Blacksburg , VA , USA.
authors.forename: Adria
authors.initials: A
authors.lastname: Carbo
authors.affiliation: a Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens; Virginia Bioinformatics Institute; Virginia Tech ; Blacksburg , VA , USA.
authors.forename: Vida
authors.initials: V
authors.lastname: Abedi
authors.affiliation: a Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens; Virginia Bioinformatics Institute; Virginia Tech ; Blacksburg , VA , USA.
authors.forename: Raquel
authors.initials: R
authors.lastname: Hontecillas
mesh_terms: D000073883:CX3C Chemokine Receptor 1; D005753:Gastric Mucosa / Q000276:immunology* / Q000382:microbiology; D005756:Gastritis / Q000276:immunology* / Q000382:microbiology; D000069196:Gastrointestinal Microbiome / Q000276:immunology*; D016481:Helicobacter Infections / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology* / Q000472:pathogenicity; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion / Q000276:immunology*; D018928:Immunity, Mucosal / Q000276:immunology; D019707:Receptors, Chemokine / Q000378:metabolism; D013559:Symbiosis / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D019707:Receptors, Chemokine
keywords: IFN-γ; bacterial pathogenesis, commensal; helicobacter pylori; host tolerance; immune evasion; information biology; treg