title: [Assisted oocyte activation: a new tool for severe male factor infertility treatment].
abstract: In severe male infertility, in vitro fertilization (IVF) with intra-cytoplasmic sperm injection (ICSI) represents the sole available therapeutic option. However this technique is not always successful in promoting fertilization, as some couples completely and repeatedly fail to obtain any embryo. In many cases, this failure can be attributed to a defective rise in intracellular calcium, which is required to achieve oocyte activation. Over the last twenty years, several laboratories dedicated to assisted reproduction technologies have been using a calcium ionophore to assist oocyte activation. The aim of this review is to give an overview of the advances and consequences associated with this new technique referred to as assisted oocyte activation.
authors.affiliation: CHU de Rennes, laboratoire de biologie de la reproduction, 16, boulevard de Bulgarie, F-35033 Rennes, France - Université de Rennes1, faculté de médecine, F-35043 Rennes, France - Inserm, IRSET U1085, F- 35042 Rennes, France.
authors.forename: Célia
authors.initials: C
authors.lastname: Ravel
authors.affiliation: CHU de Rennes, laboratoire de biologie de la reproduction, 16, boulevard de Bulgarie, F-35033 Rennes, France - Université de Rennes1, faculté de médecine, F-35043 Rennes, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Kazdar
authors.affiliation: CHU de Rennes, laboratoire de biologie de la reproduction, 16, boulevard de Bulgarie, F-35033 Rennes, France - Université de Rennes1, faculté de médecine, F-35043 Rennes, France.
authors.forename: Hortense
authors.initials: H
authors.lastname: Drapier
authors.affiliation: Université de Rennes1, faculté de médecine, F-35043 Rennes, France - CHU de Rennes, département de gynécologie-obstétrique et reproduction humaine, F-35033 Rennes, France.
authors.forename: Solène
authors.initials: S
authors.lastname: Duros
authors.affiliation: CHU de Rennes, laboratoire de biologie de la reproduction, 16, boulevard de Bulgarie, F-35033 Rennes, France - Université de Rennes1, faculté de médecine, F-35043 Rennes, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Viard
mesh_terms: D005260:Female; D006801:Humans; D059471:In Vitro Oocyte Maturation Techniques / Q000379:methods / Q000706:statistics & numerical data; D007248:Infertility, Male / Q000628:therapy*; D008297:Male; D009865:Oocytes / Q000166:cytology / Q000502:physiology*; D011247:Pregnancy; D012720:Severity of Illness Index; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods