title: The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease.
abstract: There is a growing body of evidence indicating that the mechanisms that control genome stability are of key importance in the development and function of the nervous system. The major threat for neurons is oxidative DNA damage, which is repaired by the base excision repair (BER) pathway. Functional mutations of enzymes that are involved in the processing of single-strand breaks (SSB) that are generated during BER have been causally associated with syndromes that present important neurological alterations and cognitive decline. In this review, the plasticity of BER during neurogenesis and the importance of an efficient BER for correct brain function will be specifically addressed paying particular attention to the brain region and neuron-selectivity in SSB repair-associated neurological syndromes and age-related neurodegenerative diseases.
authors.affiliation: Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy; Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Narciso
authors.affiliation: Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Parlanti
authors.affiliation: Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Racaniello
authors.affiliation: Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Simonelli
authors.affiliation: IRCCS San Raffaele Pisana, 00166 Rome, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Cardinale
authors.affiliation: Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Merlo
authors.affiliation: Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Dogliotti
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D053904:DNA Breaks, Single-Stranded; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics*; D055495:Neurogenesis / Q000235:genetics; D009474:Neurons / Q000378:metabolism*; D018384:Oxidative Stress