title: Platelet VIII pack evades immune detection.
abstract: In this issue of Blood, Chen et al demonstrate that platelets expressing factor VIII (FVIII) shield FVIII from immune detection. In the naive FVIII null hemophilia A (HA) mouse, platelet-derived VIII prevents both a primary and memory anti-FVIII immune response, and together with total body irradiation, suppresses anti-FVIII immune response.
authors.affiliation: UNIVERSITY OF PITTSBURGH MEDICAL CENTER.
authors.forename: Margaret V
authors.initials: MV
authors.lastname: Ragni
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D019774:Blood Coagulation Factor Inhibitors / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology*; D005169:Factor VIII / Q000276:immunology*; D006467:Hemophilia A / Q000276:immunology*; D017713:Platelet Transfusion
chemical_list: D001323:Autoantibodies; D019774:Blood Coagulation Factor Inhibitors; D005169:Factor VIII