title: Near-infrared measurements of brain oxygenation in stroke.
abstract: We investigated the feasibility of using frequency-domain near-infrared spectroscopy (fdNIRS) to study brain oxygenation in the first few hours of stroke onset. The OxiplexTS(®) fdNIRS system was used in this study. Using a standard probing protocol based on surface landmarks, we measured brain tHb and [Formula: see text] in healthy volunteers, cadavers, and acute stroke patients within 9 h of stroke onset and 3 days later. We obtained measurements from 11 controls, 5 cadavers, and 5 acute stroke patients. [Formula: see text] values were significantly lower in cadavers compared to the controls and stroke patients. Each stroke patient had at least one area with reduced [Formula: see text] on the stroke side compared to the contralateral side. The evolution of tHb and [Formula: see text] at 3 days differed depending on whether a large infarct occurred. This study shows the proof of principle that quantified measurements of brain oxygenation using NIRS could be used in the hectic environment of acute stroke management. It also highlights the current technical limitations and future challenges in the development of this unique bedside monitoring tool for stroke.
authors.affiliation: Université de Sherbrooke, Department of Medicine, CHUS-Hôpital Fleurimont 3001, 12e Avenue Nord, bureau 6501, Québec, Sherbrooke J1H 5N4, Canada; Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, 12th Floor, 1403-29th Street NW Calgary, Alberta T2N 2T9, Canada.
authors.forename: François
authors.initials: F
authors.lastname: Moreau
authors.affiliation: University of Calgary, Department of Radiology, Foothills Medical Centre, Room 812, North Tower, 1403-29th Street NW Calgary, Alberta T2N 2T9, Canada; University of Calgary, Hotchkiss Brain Institute, Health Research Innovation Centre, Room 1A10, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.
authors.forename: Runze
authors.initials: R
authors.lastname: Yang
authors.affiliation: Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, 12th Floor, 1403-29th Street NW Calgary, Alberta T2N 2T9, Canada; Amrita Institute Medical Sciences, Department of Neurology, Center of Neurosciences, Ponekkara, Kochi 682041, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Nambiar
authors.affiliation: Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, 12th Floor, 1403-29th Street NW Calgary, Alberta T2N 2T9, Canada; University of Calgary, Hotchkiss Brain Institute, Health Research Innovation Centre, Room 1A10, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Demchuk
authors.affiliation: University of Calgary, Department of Radiology, Foothills Medical Centre, Room 812, North Tower, 1403-29th Street NW Calgary, Alberta T2N 2T9, Canada; University of Calgary, Hotchkiss Brain Institute, Health Research Innovation Centre, Room 1A10, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada; University of Calgary, Experimental Imaging Center, TRW building, Basement level P2, Foothills Medical Centre, 1403-29th Street NW Calgary, Alberta T2N 2T9, Canada.
authors.forename: Jeff F
authors.initials: JF
authors.lastname: Dunn
keywords: brain imaging; ischemic; near-infrared; stroke