title: Intramitochondrial Ca(2+) Sensing by EMRE: The Matrix Outlook on Stimulus-Metabolism Coupling.
abstract: Mitochondrial Ca(2+) entry is an important process regulating cellular bioenergetics, redox responses, and apoptosis. The study by Vais and colleagues (Vais et al., 2016), recently published in Cell Reports, describes a novel mechanism of modulating Ca(2+) entry that involves mitochondrial matrix Ca(2+).
authors.affiliation: Department of Cellular and Molecular Physiology and NIHR Liverpool Pancreas Biomedical Research Unit, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
authors.forename: David N
authors.initials: DN
authors.lastname: Criddle
authors.affiliation: Department of Cellular and Molecular Physiology and NIHR Liverpool Pancreas Biomedical Research Unit, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK. Electronic address: a.tepikin@liverpool.ac.uk.
authors.forename: Alexei V
authors.initials: AV
authors.lastname: Tepikin
mesh_terms: D017209:Apoptosis; D002118:Calcium / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D002118:Calcium