title: Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders.
abstract: Amyloid-β (Aβ) pathology is known to promote chronic inflammatory responses in the brain. It was thought previously that Aβ is only associated with Alzheimer's disease and Down syndrome. However, studies have shown its involvement in many other neurological disorders. The role of astrocytes in handling the excess levels of Aβ has been highlighted in the literature. Astrocytes have a distinctive function in both neuronal support and protection, thus its involvement in Aβ pathological process may tip the balance toward chronic inflammation and neuronal death. In this review we describe the involvement of astrocytes in Aβ related disorders including Alzheimer's disease, Down syndrome, cerebral amyloid angiopathy, and frontotemporal dementia.
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. batarsy@warhawks.ulm.edu.
authors.forename: Yazan S
authors.initials: YS
authors.lastname: Batarseh
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. duongqa@warhawks.ulm.edu.
authors.forename: Quoc-Viet
authors.initials: QV
authors.lastname: Duong
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. mousaym@warhawks.ulm.edu.
authors.forename: Youssef M
authors.initials: YM
authors.lastname: Mousa
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. alrihasb@warhawks.ulm.edu.
authors.forename: Sweilem B
authors.initials: SB
authors.lastname: Al Rihani
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. hamadgh@warhawks.ulm.edu.
authors.forename: Khaled
authors.initials: K
authors.lastname: Elfakhri
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. kaddoumi@ulm.edu.
authors.forename: Amal
authors.initials: A
authors.lastname: Kaddoumi
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000686:Amyloidosis / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology*; D016657:Cerebral Amyloid Angiopathy / Q000378:metabolism / Q000473:pathology; D004314:Down Syndrome / Q000378:metabolism / Q000473:pathology; D057180:Frontotemporal Dementia / Q000378:metabolism / Q000473:pathology; D006801:Humans
chemical_list: D016229:Amyloid beta-Peptides
keywords: Alzheimer’s disease; Amyloid-β; Down syndrome; astrocytes; cerebral amyloid angiopathy; frontotemporal dementia