title: Loss of FBXW7 is related to the susceptibility and poor prognosis of cervical squamous carcinoma.
abstract: OBJECTIVE
  To investigate the relationship between F box/WD-40 domain protein 7 (FBXW7) and cervical squamous cancer.
  
  
  METHODS
  We investigated the FBXW7 expression in 136 cervical squamous carcinoma cases through immunohistochemistry and Western-blot analysis to evaluate the clinical significance of FBXW7 and to elucidate the relationship of FBXW7 expression with progression-free survival (PFS) and overall survival (OS).
  
  
  RESULTS
  Low FBXW7 expression was associated with high histologic grade, lymphovascular space invasion and lymph node metastasis, among other parameters. Patients with low FBXW7 expression exhibited poor OS and PFS.
  
  
  CONCLUSIONS
  FBXW7 is related to the susceptibility and prognosis of cervical squamous carcinoma, indicating FBXW7 may be a potentially important target for the prediction of prognosis.
authors.affiliation: a Department of Gynecology and.
authors.forename: Ye
authors.initials: Y
authors.lastname: Xu
authors.affiliation: b Department of Head and Neck Surgery , Harbin Medical University Cancer Hospital , Harbin , China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Yu
authors.affiliation: a Department of Gynecology and.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Liu
authors.affiliation: a Department of Gynecology and.
authors.forename: Fanling
authors.initials: F
authors.lastname: Meng
authors.affiliation: a Department of Gynecology and.
authors.forename: Dan
authors.initials: D
authors.lastname: Kong
authors.affiliation: a Department of Gynecology and.
authors.forename: Ge
authors.initials: G
authors.lastname: Lou
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D018797:Cell Cycle Proteins / Q000235:genetics*; D044783:F-Box Proteins / Q000235:genetics*; D000073979:F-Box-WD Repeat-Containing Protein 7; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011379:Prognosis; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D018797:Cell Cycle Proteins; D044783:F-Box Proteins; D000073979:F-Box-WD Repeat-Containing Protein 7; C513273:FBXW7 protein, human; D044767:Ubiquitin-Protein Ligases
keywords: Biomarker; lymph node metastasis; suppressor gene