title: Membrane Trafficking in Neuronal Development: Ins and Outs of Neural Connectivity.
abstract: During development, neurons progress through rapid yet stereotypical shape changes to achieve proper neuronal connectivity. This morphological progression requires carefully orchestrated plasma membrane expansion, insertion of membrane components including receptors for extracellular cues into the plasma membrane and removal and trafficking of membrane materials and proteins to specific locations. This review outlines the cellular machinery of membrane trafficking that play an integral role in neuronal cell shape change and function from initial neurite formation to pathway navigation and synaptogenesis.
authors.affiliation: Neuroscience Center and Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC, United States of America.
authors.forename: Cortney Chelise
authors.initials: CC
authors.lastname: Winkle
authors.affiliation: Neuroscience Center and Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC, United States of America; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America. Electronic address: sgupton@email.unc.edu.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Gupton
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D009415:Nerve Net / Q000378:metabolism*; D016501:Neurites / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*
keywords: Golgi apparatus; Golgi outposts; endocytosis; endoplasmic reticulum; exocytosis; membrane trafficking; neuron; neuronal development