title: Histological and immunohistochemical features of histiocytic sarcoma in four domestic ferrets (Mustela putorius furo).
abstract: Four cases of histiocytic sarcoma in domestic ferrets (Mustela putorius furo) are described in the present study. Tumor samples obtained from the abdominal viscera, including the spleen, were submitted for histologic examination. Microscopically, poorly demarcated masses contained numerous round- to pleomorphic-shaped cells with coarsely vacuolated and eosinophilic cytoplasm. Bizarre, binucleated tumor cells and multinucleated giant tumor cells with low phagocytic activity were commonly observed. Immunohistochemically, tumor cells in all of the cases were positive for vimentin, human leukocyte antigen-DR, ionized calcium-binding adapter molecule-1, and lysozyme, but some of them lacked cluster of differentiation (CD)163 or CD208 expression. The survival time after surgical resection was 9 days to 5 months. Histiocytic sarcoma in the ferret is a rare, but highly aggressive, tumor commonly found in the spleen.
authors.affiliation: Departments of Veterinary Pathology (Thongtharb, Uchida, Chambers, Murata, Nakayama), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, JapanVeterinary Emergency Medicine (Miwa), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Atigan
authors.initials: A
authors.lastname: Thongtharb
authors.affiliation: Departments of Veterinary Pathology (Thongtharb, Uchida, Chambers, Murata, Nakayama), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, JapanVeterinary Emergency Medicine (Miwa), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan auchidak@mail.ecc.u-tokyo.ac.jp.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.affiliation: Departments of Veterinary Pathology (Thongtharb, Uchida, Chambers, Murata, Nakayama), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, JapanVeterinary Emergency Medicine (Miwa), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: James K
authors.initials: JK
authors.lastname: Chambers
authors.affiliation: Departments of Veterinary Pathology (Thongtharb, Uchida, Chambers, Murata, Nakayama), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, JapanVeterinary Emergency Medicine (Miwa), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Yasutsugu
authors.initials: Y
authors.lastname: Miwa
authors.affiliation: Departments of Veterinary Pathology (Thongtharb, Uchida, Chambers, Murata, Nakayama), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, JapanVeterinary Emergency Medicine (Miwa), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Murata
authors.affiliation: Departments of Veterinary Pathology (Thongtharb, Uchida, Chambers, Murata, Nakayama), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, JapanVeterinary Emergency Medicine (Miwa), Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D005289:Ferrets; D054747:Histiocytic Sarcoma / Q000175:diagnosis / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary
keywords: Ferrets; histiocytic sarcoma; immunohistochemistry; pathology