title: A prospective longitudinal survey of erectile function status in symptomatic benign prostatic hyperplasia patients treated with dutasteride.
abstract: We prospectively evaluated erectile function (EF) using the Sexual Health Inventory for Men (SHIM) and the erectile hardness score (EHS) as well as urinary statuses using the International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS) before and 3, 6, and 12 months after a daily treatment with 0.5 mg dutasteride (DUT). Significant improvements were observed in IPSS and OABSS in 98 patients with the DUT treatment, and the effects were similar between 28 patients with potency with baseline SHIM of 8 or greater and 70 severe erectile dysfunction (ED) patients at baseline. In the 28 patients with potency, significant decreases were observed in SHIM and EHS after 3, 6, and 12 months of the DUT treatment, with the severity of ED according to SHIM deteriorating in half of these patients after 12 months of the DUT treatment. Eighteen out of 28 patients (64.3%) with potency at baseline had awareness of the occurrence of ED before the DUT treatment, were younger, and had higher SHIM and EHS just before the DUT treatment than their counterparts. Regular assessments of EF may be needed, especially in younger patients and those with higher levels of EF before the administration of DUT.
authors.affiliation: a Department of Urology , Keio University School of Medicine , Tokyo , Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Maeda
authors.affiliation: a Department of Urology , Keio University School of Medicine , Tokyo , Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Kikuchi
authors.affiliation: a Department of Urology , Keio University School of Medicine , Tokyo , Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Hasegawa
authors.affiliation: a Department of Urology , Keio University School of Medicine , Tokyo , Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ando
authors.affiliation: a Department of Urology , Keio University School of Medicine , Tokyo , Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Matsushima
authors.affiliation: a Department of Urology , Keio University School of Medicine , Tokyo , Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Yuge
authors.affiliation: a Department of Urology , Keio University School of Medicine , Tokyo , Japan.
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Ito
authors.affiliation: a Department of Urology , Keio University School of Medicine , Tokyo , Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Miyajima
authors.affiliation: a Department of Urology , Keio University School of Medicine , Tokyo , Japan.
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Oya
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000627:therapeutic use*; D000368:Aged; D000068538:Dutasteride / Q000627:therapeutic use*; D007172:Erectile Dysfunction / Q000188:drug therapy; D006801:Humans; D008297:Male; D010410:Penile Erection / Q000187:drug effects*; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D053201:Urinary Bladder, Overactive / Q000188:drug therapy
chemical_list: D058891:5-alpha Reductase Inhibitors; D000068538:Dutasteride
keywords: Dutasteride; Sexual Health Inventory for Men; erectile hardness score; sexual adverse events; urinary status