title: Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride.
authors.affiliation: National Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Shuqing
authors.initials: S
authors.lastname: Wang
authors.affiliation: National Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
authors.forename: Lingyu
authors.initials: L
authors.lastname: Du
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Dev
authors.affiliation: National Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
authors.forename: Liujuan
authors.initials: L
authors.lastname: Zhou
authors.affiliation: National Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Liu
authors.affiliation: National Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China. james_chou@hms.harvard.edu.|Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. james_chou@hms.harvard.edu.
authors.forename: James J
authors.initials: JJ
authors.lastname: Chou
authors.affiliation: National Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China. ouyang@sibcb.ac.cn.|Shanghai Science Research Center, Chinese Academy of Sciences, Shanghai, 201204, China. ouyang@sibcb.ac.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: OuYang
mesh_terms: D000584:Amiloride / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D056004:Molecular Dynamics Simulation; D017434:Protein Structure, Tertiary; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000086082:Viroporin Proteins
chemical_list: D000584:Amiloride; D014764:Viral Proteins; C088369:p7 protein, Hepatitis C virus; D000086082:Viroporin Proteins; C057360:5-(N,N-hexamethylene)amiloride