title: [Analysis of HA and NA Genes of Influenza A H1N1 Virus in Yunnan Province during 2009-2014].
abstract: To analyze influenza pathogen spectrum in Yunnan province during 2009-2014 years, and analyze HA and NA genes of influenza A H1N1. Analysis was made on the monitoring date of influenza cases in Yunnan province in recent 6 years, 23 strains of influenza virus of HA and NA gene was sequenced and analyzed by MEGA 5 software to construct phylogenetic tree. 4 times of influenza AH1N1 epidemic peak were monitored from 2009-2014 years in Yunnan Province, as the nucleic acid detection results of influenza A H1N1 accounted for 28.8% of the total. The sequencing result showed that HA and NA gene were divided into 3 groups, one was detected with H275Y mutation strains. Influenza A H1N1 is one of the important subtypes in Yunnan province and their genes have divided into three branches during the period of 2009-2014 years, the vast majority of influenza a H1N1 are still sensitive to neuraminidase inhibitors.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Zhao
authors.forename: Yihui
authors.initials: Y
authors.lastname: Cao
authors.forename: Deming
authors.initials: D
authors.lastname: Ning
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Fu
authors.forename: Wen
authors.initials: W
authors.lastname: Xu
mesh_terms: D002681:China / Q000453:epidemiology; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D008969:Molecular Sequence Data; D009154:Mutation; D009439:Neuraminidase / Q000235:genetics* / Q000378:metabolism; D010802:Phylogeny; D014764:Viral Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C543345:H1N1 virus hemagglutinin; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D014764:Viral Proteins; C487630:NA protein, influenza A virus; D009439:Neuraminidase