title: Temporal Changes in Androgens and Estrogens Are Associated With All-Cause and Cause-Specific Mortality in Older Men.
abstract: The dynamic temporal relationship between changes in serum reproductive hormones and mortality in men has not been reported.
  
  
  
  The objective of the study was to examine the relationship between progressive changes in circulating reproductive hormones over time with all-cause and cause-specific mortality in older men.
  
  
  
  Community-dwelling men aged 70 years and older from the Concord Health and Ageing in Men Project study were assessed at baseline (2005-2007, n = 1705) and at 2-year (n = 1367) and 5-year follow-up (n = 958).
  
  
  
  At all three time-points, T, DHT, estradiol (E2), and estrone (E1) were measured by liquid chromatography-tandem mass spectrometry, and SHBG, LH, and FSH were determined by immunoassay and calculated free T (cFT) was calculated. Mortality was ascertained through the state death registry. Statistical modeling was by general estimating equations with the Poisson regression.
  
  
  
  Serum T over time (relative risk [RR] per 1 SD decrease in concentration: 1.18, 95% confidence interval [CI] 1.05-1.32), DHT (RR 1.17, 95% CI 1.05-1.32), and E2 (RR 1.46, 95% CI 1.30-1.63) as well as cFT (RR 1.27, 95% CI 1.13-1.41) was associated with all-cause mortality. After adjusting for multiple covariables, the decline in serum T (RR 1.17, 95% CI 1.03-1.32), DHT (RR 1.17, 95% CI 1.03-1.32), and cFT (RR 1.13, 95% CI 1.08-1.19) remained significantly associated with all-cause mortality. Similar relationships were observed for cancer but not cardiovascular mortality. Progressive decline in serum E2 levels remained significantly associated with all-cause (RR 1.49, 95% CI 1.31-1.69), cancer (RR 1.82, 95% CI 1.45-2.28), and cardiovascular (RR 1.37, 95% CI 1.13-1.66) mortality, even after adjustment for covariables. Serum E1, LH, FSH, and SHBG were not associated with all-cause, cancer, or cardiovascular mortality.
  
  
  
  Dynamic temporal changes in serum T, cFT, DHT, and E2 (but not E1, LH, FSH, and SHBG) in older men are associated with all-cause and cause-specific mortality in distinct patterns.
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.J.S., D.J.H.), and Centre of Education and Research on Ageing (B.H., R.G.C., V.N., F.M.B., D.G.L.C., V.H., L.M.W.), University of Sydney and Concord Hospital, and School of Public Health (R.G.C.), University of Sydney, Sydney, New South Wales 2139, Australia.
authors.forename: Benjumin
authors.initials: B
authors.lastname: Hsu
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.J.S., D.J.H.), and Centre of Education and Research on Ageing (B.H., R.G.C., V.N., F.M.B., D.G.L.C., V.H., L.M.W.), University of Sydney and Concord Hospital, and School of Public Health (R.G.C.), University of Sydney, Sydney, New South Wales 2139, Australia.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Cumming
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.J.S., D.J.H.), and Centre of Education and Research on Ageing (B.H., R.G.C., V.N., F.M.B., D.G.L.C., V.H., L.M.W.), University of Sydney and Concord Hospital, and School of Public Health (R.G.C.), University of Sydney, Sydney, New South Wales 2139, Australia.
authors.forename: Vasi
authors.initials: V
authors.lastname: Naganathan
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.J.S., D.J.H.), and Centre of Education and Research on Ageing (B.H., R.G.C., V.N., F.M.B., D.G.L.C., V.H., L.M.W.), University of Sydney and Concord Hospital, and School of Public Health (R.G.C.), University of Sydney, Sydney, New South Wales 2139, Australia.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Blyth
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.J.S., D.J.H.), and Centre of Education and Research on Ageing (B.H., R.G.C., V.N., F.M.B., D.G.L.C., V.H., L.M.W.), University of Sydney and Concord Hospital, and School of Public Health (R.G.C.), University of Sydney, Sydney, New South Wales 2139, Australia.
authors.forename: David G
authors.initials: DG
authors.lastname: Le Couteur
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.J.S., D.J.H.), and Centre of Education and Research on Ageing (B.H., R.G.C., V.N., F.M.B., D.G.L.C., V.H., L.M.W.), University of Sydney and Concord Hospital, and School of Public Health (R.G.C.), University of Sydney, Sydney, New South Wales 2139, Australia.
authors.forename: Vasant
authors.initials: V
authors.lastname: Hirani
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.J.S., D.J.H.), and Centre of Education and Research on Ageing (B.H., R.G.C., V.N., F.M.B., D.G.L.C., V.H., L.M.W.), University of Sydney and Concord Hospital, and School of Public Health (R.G.C.), University of Sydney, Sydney, New South Wales 2139, Australia.
authors.forename: Louise M
authors.initials: LM
authors.lastname: Waite
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.J.S., D.J.H.), and Centre of Education and Research on Ageing (B.H., R.G.C., V.N., F.M.B., D.G.L.C., V.H., L.M.W.), University of Sydney and Concord Hospital, and School of Public Health (R.G.C.), University of Sydney, Sydney, New South Wales 2139, Australia.
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Seibel
authors.affiliation: ANZAC Research Institute (B.H., R.G.C., D.G.L.C., M.J.S., D.J.H.), and Centre of Education and Research on Ageing (B.H., R.G.C., V.N., F.M.B., D.G.L.C., V.H., L.M.W.), University of Sydney and Concord Hospital, and School of Public Health (R.G.C.), University of Sydney, Sydney, New South Wales 2139, Australia.
authors.forename: David J
authors.initials: DJ
authors.lastname: Handelsman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D013196:Dihydrotestosterone / Q000097:blood*; D004958:Estradiol / Q000097:blood*; D004970:Estrone / Q000097:blood*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006306:Health Surveys; D006801:Humans; D008137:Longitudinal Studies; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D015996:Survival Rate; D013739:Testosterone / Q000097:blood*
chemical_list: D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; D004970:Estrone; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone