title: HPLC analysis and pharmacokinetics of the enantiomers of R,S-oxazepam and R,S-temazepam with their corresponding glucuronide conjugates in urine and plasma of man.
abstract: R,S-Oxazepam and R,S-temazepam can be separated in their enantiomers by means of a chiral AGP column. The corresponding R- and S-glucuronide conjugates can be separated on a normal reversed-phase C18 column. Man conjugates the S-enantiomer of oxazepam and temazepam both better than the R-enantiomer. The urinary recovery of the glucuronides following either R,S,-oxazepam or R,S-temazepam almost amounts to 100% of the dose administered.
authors.affiliation: Afdeling Klinische Farmacie en Anesthesiologie,Academisch Ziekenhuis Nijmegen Sint Radboud,Geert Grooteplein Zuid 8,6525 GA Nijmegen.
authors.forename: T B
authors.initials: TB
authors.lastname: Vree
authors.affiliation: Afdeling Klinische Farmacie en Anesthesiologie,Academisch Ziekenhuis Nijmegen Sint Radboud,Geert Grooteplein Zuid 8,6525 GA Nijmegen.
authors.forename: A M
authors.initials: AM
authors.lastname: Baars
authors.affiliation: Afdeling Klinische Farmacie en Anesthesiologie,Academisch Ziekenhuis Nijmegen Sint Radboud,Geert Grooteplein Zuid 8,6525 GA Nijmegen.
authors.forename: E W
authors.initials: EW
authors.lastname: Wuis