title: Dual Catalysis: Proton/Metal-Catalyzed Tandem Benzofuran Annulation/Carbene Transfer Reaction.
abstract: An efficient proton/metal-catalyzed tandem benzofuran annulation/carbene transfer reaction for the synthesis of various benzofuryl-substituted cyclopropanes and cycloheptatrienes has been developed. The reaction was proposed to proceed through two key intermediates, o-quinone methide (o-QM) and benzofuryl carbene. The DFT-based computational studies indicated that the reaction was initiated through the dehydration of o-HBA via a Brønsted acid mediated proton shuttle transition state, forming the key intermediate o-QM.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou, 510640, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou, 510640, P. R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University , Guangzhou, 510275, P. R. China.
authors.forename: Hongguang
authors.initials: H
authors.lastname: Fu
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University , Guangzhou, 510275, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou, 510640, P. R. China.
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou, 510640, P. R. China.
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou, 510640, P. R. China.
authors.forename: Shifa
authors.initials: S
authors.lastname: Zhu