title: [STUDY OF SAFETY OF PAROTITIS VACCINE].
abstract: OBJECTIVE
  Monitoring of post-vaccinal complications in children immunized with a parotitis vaccine.
  
  
  METHODS
  Observation of 198 945 children, immunized with 16 lots of parotitis vaccine with Leningrad-3 strain (L-3), was carried out for 3 years. Paired samples of sera and saliva were obtained from children, in whom adverse events were registered for 42 days after vaccination. Titers of specific IgM and IgG were determined in blood sera. Analysis of nucleotide sequences of genes F, SH and NH of RNA of parotitis virus was carried out from samples of blood and saliva.
  
  
  RESULTS
  Intensive parameter of vaccine-associated aseptic meningitis under the conditions of the experiments was 0 for 100 000 immunized. Frequency of occurrence of post-vaccinal parotitis was 0.06% from the number of vaccinated--18 cases of vaccine-associated parotitis were registered and laboratory confirmed. A significant difference in specific activity was detected for 3 lots of the vaccine, that were associated with cases of development of parotitis, relative to that of 13 lots of vaccine, development of parotitis was not registered after administration of those.
  
  
  CONCLUSIONS
  The study carried out confirmed low neurovirulence of the parotitis vaccine with the L-3 strain of parotitis virus, as well as a low degree of its reactogenicity. A relatively high immunization dose of the used vaccine could be one of the reasons of development of post-vaccinal complications in part of the immunized children.
authors.forename: G M
authors.initials: GM
authors.lastname: Ignatiev
authors.forename: M V
authors.initials: MV
authors.lastname: Kulak
authors.forename: E V
authors.initials: EV
authors.lastname: Otrashevskaya
authors.forename: E K
authors.initials: EK
authors.lastname: Bukin
authors.forename: A A E
authors.initials: AA
authors.lastname: Nesterov
authors.forename: M A
authors.initials: MA
authors.lastname: Gorbunov
authors.forename: V N
authors.initials: VN
authors.lastname: Mikheev
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D008297:Male; D010306:Parotid Gland / Q000276:immunology / Q000473:pathology / Q000821:virology; D010309:Parotitis / Q000276:immunology / Q000473:pathology / Q000517:prevention & control* / Q000821:virology; D061214:Patient Safety; D012367:RNA, Viral / Q000097:blood*; D012426:Russia; D012463:Saliva / Q000276:immunology / Q000821:virology; D014611:Vaccination; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000096:biosynthesis / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral; D014765:Viral Vaccines