title: Bioactive Secondary Metabolites with Unique Aromatic and Heterocyclic Structures Obtained from Terrestrial Actinomycetes Species.
abstract: Natural products from actinomycetes are important and valuable sources for drug discovery and the development of biological tools. The present review describes our recent study on the isolation of new natural products mainly possessing heterocyclic and aromatic ring structures with biological effects on cancer-related cellular pathways such as tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL) and Wnt signaling.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University.
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Abdelfattah
authors.forename: Midori A
authors.initials: MA
authors.lastname: Arai
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D039903:Actinobacteria / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D064210:Secondary Metabolism; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000037:antagonists & inhibitors / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000187:drug effects
chemical_list: D001688:Biological Products; D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human