title: The interaction between histamine H1 receptor and μ- opioid receptor in scratching behavior in ICR mice.
abstract: In this study, we examined the interaction between histamine H1 receptor and μ-opioid receptor in scratching behavior in ICR mice. Both histamine and morphine caused scratching and simultaneous injection of histamine and morphine had an additive effect. Chlorpheniramine and naloxone inhibited histamine-induced scratching behavior. These two drugs also inhibited morphine-induced scratching behavior. Simultaneous injection of chlorpheniramine and naloxone caused a significant inhibition of histamine-induced scratching compared with separate injections. The same findings were also noted for morphine-induced scratching. These results strongly indicate a close relationship between histamine H1 receptor and μ-opioid receptor in scratching behavior in ICR mice.
authors.affiliation: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Yasuda Women's University, 6-13-1, Yasuhigashi, Asaminami-Ku, Hiroshima 731-0153, Japan.
authors.forename: Tasuku
authors.initials: T
authors.lastname: Nakasone
authors.affiliation: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Yasuda Women's University, 6-13-1, Yasuhigashi, Asaminami-Ku, Hiroshima 731-0153, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Sugimoto
authors.affiliation: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Yasuda Women's University, 6-13-1, Yasuhigashi, Asaminami-Ku, Hiroshima 731-0153, Japan. Electronic address: kamei-c@yasuda-u.ac.jp.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kamei
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002744:Chlorpheniramine / Q000494:pharmacology / Q000627:therapeutic use; D006632:Histamine / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology / Q000627:therapeutic use; D011485:Protein Binding; D011537:Pruritus / Q000188:drug therapy / Q000378:metabolism; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D017450:Receptors, Opioid, mu / Q000378:metabolism*
chemical_list: D011969:Receptors, Histamine H1; D017450:Receptors, Opioid, mu; D009270:Naloxone; D002744:Chlorpheniramine; D009020:Morphine; D006632:Histamine
keywords: Chlorpheniramine; Histamine; ICR mice; Morphine; Naloxone; Scratching behavior