title: Cerebral and Muscle Oxygenation During Intermittent Hypoxia Exposure in Healthy Humans.
abstract: To evaluate changes in muscle and cerebral oxygenation during intermittent hypoxia (IH).
  
  
  
  Fifteen healthy subjects were exposed to 45-min IH (2-min cycles). Arterial blood oxygen saturation (SpO2), prefrontal cortex and brachial biceps muscle oxygenation (assessed by near-infrared spectroscopy), heart rate, and ventilation were continuously recorded.
  
  
  
  During 2-min IH cycles, changes in SpO2 (9.2% ± 3.3%) were associated with significant changes in cortex oxygenation (3.2% ± 1.8%), minute ventilation, and heart rate, but no change in muscle oxygenation (0.2% ± 1.0%).
  
  
  
  Fluctuations of blood oxygen levels comparable to severe obstructive sleep apnea translate into distinct pattern of oxygenation changes in the muscle and cortex.
authors.affiliation: Université Savoie Mont Blanc, Laboratoire de Physiologie de l'Exercice, Chambéry, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Rupp
authors.affiliation: Université Savoie Mont Blanc, Laboratoire de Physiologie de l'Exercice, Chambéry, France.
authors.forename: Arthur
authors.initials: A
authors.lastname: Peyrard
authors.affiliation: University Grenoble Alpes, HP2 laboratory, Grenoble, France.|INSERM, U1042, Grenoble, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: Tamisier
authors.affiliation: University Grenoble Alpes, HP2 laboratory, Grenoble, France.|INSERM, U1042, Grenoble, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Pepin
authors.affiliation: University Grenoble Alpes, HP2 laboratory, Grenoble, France.|INSERM, U1042, Grenoble, France.
authors.forename: Samuel
authors.initials: S
authors.lastname: Verges
mesh_terms: D000328:Adult; D064368:Healthy Volunteers; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism*; D010092:Oximetry; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism*; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000378:metabolism; D019265:Spectroscopy, Near-Infrared
chemical_list: D010100:Oxygen
keywords: brain; intermittent hypoxia; muscle; sleep apnea; tissue oxygenation