title: BLOCKADE OF PGE2, PGD2 RECEPTORS CONFERS PROTECTION AGAINST PREPATENT SCHISTOSOMIASIS MANSONI IN MICE.
abstract: Schistosomiasis is a chronic disease with considerable social impact. Despite the availability of affordable chemotherapy, drug treatment has not significantly reduced the overall number of disease cases. Among other mechanisms, the parasite produces PGE2 and PGD2 to evade host immune defenses. To investigate the role of PGE2 and PGD2 in schistosomiasis, we evaluated the effects of L-161,982, Ah6809 (PGE2 receptor antagonists alone of combined with each other) and MK-0524 (PGD2 receptor antagonist) during prepatent Schistosoma mansoni infection. Drugs were administered intraperitoneally an hour before and 24 hours after infection of C57BL/6 mice with 100 Schistosoma mansoni cercariae. L-161,982, Ah6809, their combination and MK-0524 caused partial protection against pre-patent S. mansoni infection which was mediated by biasing the immune response towards Th1 phenotype. These results showed that blockade of PGE2 and PGD2 receptors confers partial protection against pre-patent S. mansoni infection in mice and that they may be useful as adjunctive therapy to current anti-schistosomal drugs or vaccines.
authors.forename: Rasha
authors.initials: R
authors.lastname: Abdel-Ghany
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Rabia
authors.forename: Eman
authors.initials: E
authors.lastname: El-Ahwany
authors.forename: Sameh
authors.initials: S
authors.lastname: Saber
authors.forename: Rasha
authors.initials: R
authors.lastname: Gamal
authors.forename: Faten
authors.initials: F
authors.lastname: Nagy
authors.forename: Olaa
authors.initials: O
authors.lastname: Mahmoud
authors.forename: Rabab Salem
authors.initials: RS
authors.lastname: Hamad
authors.forename: Walled
authors.initials: W
authors.lastname: Barakat
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D007211:Indoles / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors*; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors*; D018078:Receptors, Prostaglandin E / Q000037:antagonists & inhibitors*; D012555:Schistosomiasis mansoni / Q000517:prevention & control*; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000502:physiology; D013876:Thiophenes / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D044004:Xanthones / Q000494:pharmacology*
chemical_list: D016207:Cytokines; D007211:Indoles; C508711:L-161982; C518174:MK-0524; D011448:Prostaglandin Antagonists; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D018078:Receptors, Prostaglandin E; D013876:Thiophenes; D014230:Triazoles; D044004:Xanthones; C053876:6-isopropoxy-9-oxoxanthene-2-carboxylic acid; C036293:prostaglandin D2 receptor