title: [Gentamicin pharmacokinetics in term newborn: ¿Is it necessary to systematically monitor plasmatic levels?].
abstract: BACKGROUND
  Gentamicin is indicated as empiric treatment for neonatal sepsis. Plasmatic levels dosification of gentamicin is a common practice. The relationship between peak plasma concentration (Cmáx) with minimum inhibitory concentration (MIC) (Cmáx/MIC) is the parameter that best predicts treatment efficacy.
  
  
  OBJECTIVE
  To determine pharmacokinetics of gentamicin in term newborn infants.
  
  
  METHODS
  Term newborn infants receiving gentamicin, without critical illness in which plasmatic levels of gentamicin was performed were included. Elimination clearance (Cl) elimination half-life (t½) and volume of distribution (Vd) were calculated. In each case the value of Cmax/MIC parameter was calculated, considering a MIC value of 1 μg/mL for Escherichia coli.
  
  
  RESULTS
  Thirteen newborns were included. The mean PK values were Cl: 0.26 mL/hour, Vd: 0.54 L/kg and t½: 6.8 h. Cmax/MIC was > 8 in 6 newborns.
  
  
  CONCLUSIONS
  Pharmacokinetic parameters of gentamicin are predictable in term newborn infants. With gentamicin doses normally used Cmax/MIC values reached 8 in 6 newborns. It is necessary to review the usefulness of plasma drug monitoring and gentamicin dosage in this group of newborns.
authors.forename: Héctor
authors.initials: H
authors.lastname: Telechea
authors.forename: Juan
authors.initials: J
authors.lastname: Gesuele
authors.forename: Pedro
authors.initials: P
authors.lastname: Grosso
authors.forename: Florencia
authors.initials: F
authors.lastname: Galarraga
authors.forename: Florencia
authors.initials: F
authors.lastname: Guzzo
authors.forename: Noelia
authors.initials: N
authors.lastname: Speranza
authors.forename: Fernando
authors.initials: F
authors.lastname: Antúnez
authors.forename: Luciana
authors.initials: L
authors.lastname: Nanni
authors.forename: Gustavo
authors.initials: G
authors.lastname: Giachetto
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D016903:Drug Monitoring; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins