title: High-throughput «Omics» technologies: New tools for the study of triple-negative breast cancer.
abstract: Triple negative breast cancer (TNBC) represents about 15% to 20% of all breast cancers and is typically associated with poorer outcome than other breast cancer subtypes. The heterogeneity of this breast cancer subtype and present lack of clinically established targeted therapies further complicates treatment of patients. The treatment of TNBC emphasizes enhancing health care and developing personalized medicine. To respond to this need, the researchers have turned their attention to a different approach to scientific enquiry: the era of "big biology" and the integrative study of biological systems, also called "Omics" technologies. The term omics comprises different fields of molecular studies and characterizes a global view on biological molecules such as DNA, RNA, proteins, and metabolites. Combined "omics" approach offers a major tool for the understanding of a challenging cancer model, TNBC. This review discusses the different discoveries made using omics technologies concerning the molecular mechanisms underlying TNBC phenotypic heterogeneity, and their potential transfer to clinical applications.
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri-Dunant, 63001, Clermont-Ferrand, France; EA 4677 "ERTICA", University of Auvergne, 63011, Clermont-Ferrand, France.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Judes
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri-Dunant, 63001, Clermont-Ferrand, France; EA 4677 "ERTICA", University of Auvergne, 63011, Clermont-Ferrand, France.
authors.forename: Khaldoun
authors.initials: K
authors.lastname: Rifaï
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri-Dunant, 63001, Clermont-Ferrand, France; EA 4677 "ERTICA", University of Auvergne, 63011, Clermont-Ferrand, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Daures
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri-Dunant, 63001, Clermont-Ferrand, France; EA 4677 "ERTICA", University of Auvergne, 63011, Clermont-Ferrand, France.
authors.forename: Lucas
authors.initials: L
authors.lastname: Dubois
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri-Dunant, 63001, Clermont-Ferrand, France; EA 4677 "ERTICA", University of Auvergne, 63011, Clermont-Ferrand, France. Electronic address: yves-jean.bignon@cjp.fr.
authors.forename: Yves-Jean
authors.initials: YJ
authors.lastname: Bignon
authors.affiliation: EA 4677 "ERTICA", University of Auvergne, 63011, Clermont-Ferrand, France; Department of Pathology, Centre Jean Perrin, 63011, Clermont-Ferrand, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Penault-Llorca
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri-Dunant, 63001, Clermont-Ferrand, France; EA 4677 "ERTICA", University of Auvergne, 63011, Clermont-Ferrand, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Bernard-Gallon
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D019295:Computational Biology; D004273:DNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D030541:Databases, Genetic; D044127:Epigenesis, Genetic; D057890:Epigenomics / Q000379:methods; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D023281:Genomics / Q000379:methods*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D025202:Molecular Diagnostic Techniques; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D057285:Precision Medicine; D011237:Predictive Value of Tests; D011379:Prognosis; D060066:Protein Interaction Maps; D040901:Proteomics / Q000379:methods; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D059467:Transcriptome; D064726:Triple Negative Breast Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm
keywords: Clinical applications; Epigenomics; Genomics; Proteomics; Transcriptomics; Triple-negative breast cancer