title: Visible Light and pH Responsive Polymer-Coated Mesoporous Silica Nanohybrids for Controlled Release.
abstract: A visible light and pH responsive anticancer drug delivery system based on polymer-coated mesoporous silica nanoparticles (MSNs) has been developed. Perylene-functionalized poly(dimethylaminoethyl methacrylates) sensitive to visible light and pH are electrostatically attached on the surface of MSNs to seal the nanopores. Stimulation of visible light and acid can unseal the nanopores to induce controlled drug release from the MSNs. More interestingly, the release can be enhanced under the combined stimulation of the dual-stimuli. The synergistic effect of visible light and acid stimulation on the efficient release of anticancer drugs from the nanohybrids endows the system with great potential for cancer therapy.
authors.affiliation: School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
authors.forename: Guojie
authors.initials: G
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.affiliation: School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Yuan
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, China.
authors.forename: Juchen
authors.initials: J
authors.lastname: Zhang
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D065546:Drug Liberation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008027:Light; D008689:Methacrylates / Q000737:chemistry / Q000627:therapeutic use; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008689:Methacrylates; D011108:Polymers; D012822:Silicon Dioxide
keywords: nanocomposites; self-assembly; stimuli-sensitive polymers; thin films