title: Platelet-Rich Fibrin Improves the Viability of Diced Cartilage Grafts in a Rabbit Model.
abstract: BACKGROUND
  Diced cartilage may be wrapped with synthetic or biological materials before grafting to a recipient site. These materials have unique advantages and disadvantages, and a gold standard is not available.
  
  
  OBJECTIVE
  The authors investigated the effects of platelet-rich fibrin (PRF) on the survival of cartilage grafts in a rabbit model.
  
  
  METHODS
  In this experimental study, diced cartilage pieces from the ears of 9 male rabbits were left unwrapped or were wrapped with PRF, oxidized regenerated cellulose, or fascia. Specimens then were placed into subcutaneous pockets prepared on the backs of the rabbits. The animals were sacrificed 2 months after the procedure, and the grafts were excised for macroscopic and histopathologic examination.
  
  
  RESULTS
  The cartilage graft wrapped with PRF showed superior viability compared with the cartilage graft wrapped with oxidized regenerated cellulose. No significant differences were found among the other groups. The groups were not significantly different in terms of rates of inflammation, fibrosis, or vascularization.
  
  
  CONCLUSIONS
  PRF enhances the viability of diced cartilage grafts and should be considered an appropriate biological wrapping material for cartilage grafting.
authors.affiliation: Dr Göral is a Specialist, Department of Plastic, Reconstructive, and Aesthetic Surgery, Manisa Merkezefendi State Hospital, Manisa, Turkey. Dr Aslan is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, İzmir University School of Medicine, İzmir, Turkey. Dr Küçükzeybek is a Specialist, Department of Pathology, Kâtip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey. Dr Işık is an Associate Professor, Dr Hoşnuter is a Professor, and Dr Durgun is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, Kâtip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Göral
authors.affiliation: Dr Göral is a Specialist, Department of Plastic, Reconstructive, and Aesthetic Surgery, Manisa Merkezefendi State Hospital, Manisa, Turkey. Dr Aslan is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, İzmir University School of Medicine, İzmir, Turkey. Dr Küçükzeybek is a Specialist, Department of Pathology, Kâtip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey. Dr Işık is an Associate Professor, Dr Hoşnuter is a Professor, and Dr Durgun is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, Kâtip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Aslan
authors.affiliation: Dr Göral is a Specialist, Department of Plastic, Reconstructive, and Aesthetic Surgery, Manisa Merkezefendi State Hospital, Manisa, Turkey. Dr Aslan is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, İzmir University School of Medicine, İzmir, Turkey. Dr Küçükzeybek is a Specialist, Department of Pathology, Kâtip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey. Dr Işık is an Associate Professor, Dr Hoşnuter is a Professor, and Dr Durgun is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, Kâtip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey.
authors.forename: Betül
authors.initials: B
authors.lastname: Bolat Küçükzeybek
authors.affiliation: Dr Göral is a Specialist, Department of Plastic, Reconstructive, and Aesthetic Surgery, Manisa Merkezefendi State Hospital, Manisa, Turkey. Dr Aslan is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, İzmir University School of Medicine, İzmir, Turkey. Dr Küçükzeybek is a Specialist, Department of Pathology, Kâtip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey. Dr Işık is an Associate Professor, Dr Hoşnuter is a Professor, and Dr Durgun is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, Kâtip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey.
authors.forename: Dağhan
authors.initials: D
authors.lastname: Işık
authors.affiliation: Dr Göral is a Specialist, Department of Plastic, Reconstructive, and Aesthetic Surgery, Manisa Merkezefendi State Hospital, Manisa, Turkey. Dr Aslan is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, İzmir University School of Medicine, İzmir, Turkey. Dr Küçükzeybek is a Specialist, Department of Pathology, Kâtip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey. Dr Işık is an Associate Professor, Dr Hoşnuter is a Professor, and Dr Durgun is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, Kâtip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey.
authors.forename: Mübin
authors.initials: M
authors.lastname: Hoşnuter
authors.affiliation: Dr Göral is a Specialist, Department of Plastic, Reconstructive, and Aesthetic Surgery, Manisa Merkezefendi State Hospital, Manisa, Turkey. Dr Aslan is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, İzmir University School of Medicine, İzmir, Turkey. Dr Küçükzeybek is a Specialist, Department of Pathology, Kâtip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey. Dr Işık is an Associate Professor, Dr Hoşnuter is a Professor, and Dr Durgun is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, Kâtip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Durgun
mesh_terms: D000818:Animals; D064592:Autografts; D001792:Blood Platelets / Q000378:metabolism*; D002356:Cartilage / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000637:transplantation*; D002483:Cellulose, Oxidized / Q000494:pharmacology; D005337:Fibrin / Q000008:administration & dosage* / Q000378:metabolism; D006085:Graft Survival / Q000187:drug effects; D008297:Male; D023421:Models, Animal; D011817:Rabbits; D015503:Surgical Sponges; D013997:Time Factors; D014022:Tissue Survival / Q000187:drug effects
chemical_list: D002483:Cellulose, Oxidized; D005337:Fibrin