title: Animal models of head and neck squamous cell carcinoma.
abstract: Head and neck squamous cell carcinoma (HNSCC) is the most common oral cancer worldwide. Local bone invasion into the maxilla or mandible and metastasis to regional lymph nodes often result in a poor prognosis, decreased quality of life and shortened survival time for HNSCC patients. Poor response to treatment and clinical outcomes are the major concerns in this aggressive cancer. Multiple animal models have been developed to replicate spontaneous HNSCC and investigate genetic alterations and novel therapeutic targets. This review provides an overview of HNSCC as well as the traditional animal models used in HNSCC preclinical research. The value and challenges of each in vivo model are discussed. Similarity between HNSCC in humans and cats and the possibility of using spontaneous feline oral squamous cell carcinoma (FOSCC) as a model for HNSCC in translational research are highlighted.
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA.
authors.forename: Wachiraphan
authors.initials: W
authors.lastname: Supsavhad
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA.
authors.forename: Wessel P
authors.initials: WP
authors.lastname: Dirksen
authors.affiliation: Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3, Canada.
authors.forename: Chelsea K
authors.initials: CK
authors.lastname: Martin
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA. Electronic address: rosol.1@osu.edu.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Rosol
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D002415:Cats; D006224:Cricetinae; D004195:Disease Models, Animal; D004285:Dogs; D006258:Head and Neck Neoplasms / Q000235:genetics; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental; D051381:Rats; D012307:Risk Factors; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: Animal model; Feline oral squamous cell carcinoma; Head and neck squamous cell carcinoma