title: Reduced intensity allogeneic stem cell transplantation for follicular lymphoma relapsing after an autologous transplant achieves durable long-term disease control: an analysis from the Lymphoma Working Party of the EBMT†.
abstract: BACKGROUND
  Patients with follicular lymphoma (FL) relapsing after an autologous transplant (autoSCT) may be treated with a variety of therapies, including a reduced intensity allogeneic transplant (RICalloSCT). We conducted a retrospective analysis of a large cohort of patients undergoing RICalloSCT for FL in this setting.
  
  
  METHODS
  A total of 183 patients, median age 45 years (range 21-69), had undergone an autoSCT at a median of 30 months before the RICalloSCT. Before the RICalloSCT, they had received a median of four lines (range 3-10) of therapy and 81% of patients had chemosensitive disease and 16% had chemoresistant disease. Grafts were donated from sibling (47%) or unrelated donors (53%).
  
  
  RESULTS
  With a median follow-up of 59 months, the non-relapse mortality (NRM) was 27% at 2 years. The median remission duration post-autoSCT and RICalloSCT was 14 and 43 months, respectively. The 5-year relapse/progression rate, progression-free survival and overall survival were 16%, 48% and 51%, respectively, and were associated with age and disease status at RICalloSCT.
  
  
  CONCLUSIONS
  These data suggest that an RICalloSCT is an effective salvage strategy in patients with FL recurring after a prior autoSCT and might overcome the poor prognostic impact of early relapse after autoSCT.
authors.affiliation: BMT Unit, University Hospital Bristol NHS Foundation Trust, Bristol, UK; Lymphoma Working Party EBMT, Paris, France. Electronic address: stephen.robinson@ubht.nhs.uk.
authors.forename: S P
authors.initials: SP
authors.lastname: Robinson
authors.affiliation: Lymphoma Working Party EBMT, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Boumendil
authors.affiliation: Lymphoma Working Party EBMT, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Finel
authors.affiliation: Department of Haematology, University Hospital, Maastricht, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Schouten
authors.affiliation: Department of Haematology, Universitaetsklinikum, Dresden, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Ehninger
authors.affiliation: Department of Haematology, University Hospital Gasthuisberg, Leuven, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Maertens
authors.affiliation: Department of Haematology, Addenbrookes Hospital, Cambridge, UK.
authors.forename: C
authors.initials: C
authors.lastname: Crawley
authors.affiliation: Haematology and Bone Marrow Transplant Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Rambaldi
authors.affiliation: Department of Haematology, City Hospital, Nottingham, UK.
authors.forename: N
authors.initials: N
authors.lastname: Russell
authors.affiliation: Department of Haematology, University Hospital, Umea, Sweden.
authors.forename: W
authors.initials: W
authors.lastname: Anders
authors.affiliation: Department of Haematology, Institut Paoli Calmettes, Marseille.
authors.forename: D
authors.initials: D
authors.lastname: Blaise
authors.affiliation: Department of Haematology, Hôpital Claude Huriez, Lille, France.
authors.forename: I
authors.initials: I
authors.lastname: Yakoub-Agha
authors.affiliation: Department of Haematology, Medical School, Hannover, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Ganser
authors.affiliation: Department of Haematology, Istituto Clinico Humanitas, Milano, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Castagna
authors.affiliation: HUH Comprehensive Cancer Center, Stem Cell Transplantation Unit, Helsinki, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Volin
authors.affiliation: Haematology, Clinique Universitaire d'Hématologie CHU Grenoble UMR 38043, Grenoble Cedex 09, France.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Cahn
authors.affiliation: Lymphoma Working Party EBMT, Paris, France; Department of Haematology, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Montoto
authors.affiliation: Lymphoma Working Party EBMT, Paris, France; Department of Medicine V, University of Heidelberg, Heidelberg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Dreger
keywords: follicular lymphoma; reduced intensity allogeneic stem cell transplant