title: Lipids and Oxidative Stress Associated with Ethanol-Induced Neurological Damage.
abstract: The excessive intake of alcohol is a serious public health problem, especially given the severe damage provoked by chronic or prenatal exposure to alcohol that affects many physiological processes, such as memory, motor function, and cognitive abilities. This damage is related to the ethanol oxidation in the brain. The metabolism of ethanol to acetaldehyde and then to acetate is associated with the production of reactive oxygen species that accentuate the oxidative state of cells. This metabolism of ethanol can induce the oxidation of the fatty acids in phospholipids, and the bioactive aldehydes produced are known to be associated with neurotoxicity and neurodegeneration. As such, here we will review the role of lipids in the neuronal damage induced by ethanol-related oxidative stress and the role that lipids play in the related compensatory or defense mechanisms.
authors.affiliation: Tecnologico de Monterrey, Escuela Nacional de Medicina, 64710 Monterrey, NL, Mexico.
authors.forename: José A
authors.identifier: 0000-0003-4556-7257
authors.initials: JA
authors.lastname: Hernández
authors.affiliation: Tecnologico de Monterrey, Escuela Nacional de Medicina, 64710 Monterrey, NL, Mexico.
authors.forename: Rosa C
authors.identifier: 0000-0002-6200-1397
authors.initials: RC
authors.lastname: López-Sánchez
authors.affiliation: Unidad de Biofísica (CSIC, UPV/EHU) and Departamento de Bioquímica, Universidad del País Vasco, Apartado 644, 48080 Bilbao, Spain.
authors.forename: Adela
authors.identifier: 0000-0002-6850-6396
authors.initials: A
authors.lastname: Rendón-Ramírez
mesh_terms: D000085:Acetates / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D000431:Ethanol / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D000085:Acetates; D000975:Antioxidants; D000431:Ethanol