title: Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity.
abstract: Context Acetaminophen (APAP), also known as paracetamol and N-acetyl p-aminophenol, is one of the most frequently used drugs for analgesic and antipyretic purposes on a worldwide basis. It is safe and effective at recommended doses but has the potential for causing hepatotoxicity and acute liver failure (ALF) with overdose. To solve this problem, different strategies have been developed, including the use of compounds isolated from food, which have been studied to characterize their efficacy as natural dietary antioxidants. Objective The objective of this study is to show the beneficial effects of a variety of natural compounds and their use against acetaminophen-induced hepatotoxicity. Methods PubMed database was reviewed to compile data about natural compounds with hepatoprotective effects against APAP toxicity. Results and conclusion As a result, the health-promoting properties of 13 different food-derived compounds with protective effect against APAP-induced hepatotoxicity were described as well as the mechanisms involved in hepatoprotection.
authors.affiliation: a Department of Biology, Faculty of Chemistry , National Autonomous University of Mexico (UNAM) , University City , Mexico City , DF , Mexico.
authors.forename: Dianelena
authors.initials: D
authors.lastname: Eugenio-Pérez
authors.affiliation: a Department of Biology, Faculty of Chemistry , National Autonomous University of Mexico (UNAM) , University City , Mexico City , DF , Mexico.
authors.forename: Héctor Adolfo
authors.initials: HA
authors.lastname: Montes de Oca-Solano
authors.affiliation: a Department of Biology, Faculty of Chemistry , National Autonomous University of Mexico (UNAM) , University City , Mexico City , DF , Mexico.
authors.forename: José
authors.initials: J
authors.lastname: Pedraza-Chaverri
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D058633:Antipyretics / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D019610:Cytoprotection; D004032:Diet; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D018712:Analgesics, Non-Narcotic; D000975:Antioxidants; D058633:Antipyretics; D000082:Acetaminophen
keywords: Antioxidant capacity; liver damage; natural compounds; oxidative stress