title: Perioperative immunonutrition in normo-nourished patients undergoing laparoscopic colorectal resection.
abstract: To determine whether the joint implementation of immunonutrition and a laparoscopic approach improves morbidity, mortality, and length of stay (LOS) compared with dietary advice.
  
  
  
  Despite progress in recent years in the surgical management of patients with colorectal cancer, postoperative complications are frequent. Nutritional supplements enriched with immunonutrients have recently been introduced into clinical practice. However, the immunonutrition benefits in patients undergoing colorectal laparoscopic surgery are unknown.
  
  
  
  This study was a prospective, randomized trial with two parallel treatment groups receiving an immune-enhancing dietary supplement for 7 days before colorectal resection and 5 days postoperatively or dietary advice.
  
  
  
  A total of 128 patients were randomized. At baseline, both groups were comparable with respect to age, sex, surgical risk, comorbidities, and analytical and nutritional parameters. The median postoperative LOS was 5 days and was not significantly different between the groups. Wound infection differed significantly between the groups (11.50 vs. 0.00 %, p = 0.006). No other differences between the groups were identified.
  
  
  
  The joint use of laparoscopy and supplementation with immunonutrients reduces surgical wound infection in patients undergoing colorectal surgery.
  
  
  
  This study is registered with ClinicalTrial.gov : NCT0239396.
authors.affiliation: Department of Surgery and Pathology, University Miguel Hernandez of Elche, Elche, Spain. pedromoyaforcen@gmail.com.|Division of Colorectal Surgery, Department of General Surgery, University General Hospital of Elche, Elche, Spain. pedromoyaforcen@gmail.com.
authors.forename: Pedro
authors.initials: P
authors.lastname: Moya
authors.affiliation: Department of Anaesthesia, University General Hospital of Elche, Elche, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Miranda
authors.affiliation: Department of Surgery and Pathology, University Miguel Hernandez of Elche, Elche, Spain.
authors.forename: Leticia
authors.initials: L
authors.lastname: Soriano-Irigaray
authors.affiliation: Department of Surgery and Pathology, University Miguel Hernandez of Elche, Elche, Spain.|Division of Colorectal Surgery, Department of General Surgery, University General Hospital of Elche, Elche, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Arroyo
authors.affiliation: Division of Colorectal Surgery, Department of General Surgery, University General Hospital of Elche, Elche, Spain.
authors.forename: Maria-Del-Mar
authors.initials: MD
authors.lastname: Aguilar
authors.affiliation: Division of Colorectal Surgery, Department of General Surgery, University General Hospital of Elche, Elche, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Bellón
authors.affiliation: Department of Anaesthesia, University General Hospital of Elche, Elche, Spain.
authors.forename: Jose-Luis
authors.initials: JL
authors.lastname: Muñoz
authors.affiliation: Department of Surgery and Pathology, University Miguel Hernandez of Elche, Elche, Spain.|Division of Colorectal Surgery, Department of General Surgery, University General Hospital of Elche, Elche, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Candela
authors.affiliation: Department of Surgery and Pathology, University Miguel Hernandez of Elche, Elche, Spain.|Division of Colorectal Surgery, Department of General Surgery, University General Hospital of Elche, Elche, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Calpena
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000601:surgery*; D019587:Dietary Supplements; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D010535:Laparoscopy; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission; D019990:Perioperative Care; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000209:etiology
keywords: Immunonutrition; Laparoscopic; Surgical complication