title: Molecularly Imprinted Polymer-Decorated Magnetite Nanoparticles for Selective Sulfonamide Detection.
abstract: Sulfonamides are known not only to be antimicrobial drugs that lead to antimicrobial resistance but also to be chemotherapeutic agents that may be allergenic and potentially carcinogenic, which represents a potentially hazardous compound once present in soil or water. Herein, a hybrid material based on molecularly imprinted polymer (MIP)-decorated magnetite nanoparticles for specific and label-free sulfonamide detection is reported. The composite has been characterized using different spectroscopic and imaging techniques. The magnetic properties of the composite are used to separate, preconcentrate, and manipulate the analyte which is selectively captured by the MIP onto the surface of the composite. Screen printed electrodes have been employed to monitor the impedance levels of the whole material, which is related to the amount of the captured analyte, via electrochemical impedance spectroscopy. This composite-based sensing system exhibits an extraordinary limit of detection of 1 × 10(-12) mol L(-1) (2.8 × 10(-4) ppb) (S/N = 3), which is close to those obtained with liquid chromatography and mass spectrometry, and it was demonstrated to screen sulfamethoxazole in a complex matrix such as seawater, where according to the literature sulfonamides content is minimum compared with other environmental samples.
authors.affiliation: Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technolgy , Campus UAB, Bellaterra, 08193 Barcelona, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Zamora-Gálvez
authors.affiliation: Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technolgy , Campus UAB, Bellaterra, 08193 Barcelona, Spain.|Faculty of Science and Techniques, Hassan II University of Casablanca , B.P.146, 20650, Mohammedia, Morocco.
authors.forename: Abdellatif
authors.initials: A
authors.lastname: Ait-Lahcen
authors.affiliation: Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technolgy , Campus UAB, Bellaterra, 08193 Barcelona, Spain.|National Laboratory for Nanotechnology in Agribusiness (LNNA), Embrapa Instrumentation, 13560-970, São Carlos, São Paulo Brazil.
authors.forename: Luiza A
authors.initials: LA
authors.lastname: Mercante
authors.affiliation: Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technolgy , Campus UAB, Bellaterra, 08193 Barcelona, Spain.
authors.forename: Eden
authors.initials: E
authors.lastname: Morales-Narváez
authors.affiliation: Faculty of Science and Techniques, Hassan II University of Casablanca , B.P.146, 20650, Mohammedia, Morocco.
authors.forename: Aziz
authors.initials: A
authors.lastname: Amine
authors.affiliation: Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technolgy , Campus UAB, Bellaterra, 08193 Barcelona, Spain.|ICREA-Catalan Institution for Research and Advanced Studies , Barcelona, 08010, Spain.
authors.forename: Arben
authors.initials: A
authors.lastname: Merkoçi
mesh_terms: D055664:Electrochemical Techniques; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D054802:Molecular Imprinting; D011108:Polymers / Q000737:chemistry*; D013449:Sulfonamides / Q000032:analysis*
chemical_list: D058185:Magnetite Nanoparticles; D011108:Polymers; D013449:Sulfonamides