title: Female patients with lymphoma demonstrate diminished ovarian reserve even before initiation of chemotherapy when compared with healthy controls and patients with other malignancies.
abstract: OBJECTIVE
  The purpose of this study is to investigate if female patients with lymphoma demonstrate diminished ovarian reserve prior to initiation of the lymphoma treatment.
  
  
  METHODS
  Sixty-four patients with newly diagnosed lymphoma undergoing controlled ovarian hyperstimulation for fertility preservation were compared with 365 healthy controls undergoing elective oocyte cryopreservation (controlled ovarian hyperstimulation (COH)) and 128 patients with other types of malignancy prompting fertility preservation. The data of all lymphoma patients, all elective, and all the patients with other types of malignancy who met the inclusion criteria and underwent COH for fertility preservation during the study period were retrospectively analyzed. Primary outcomes included serum anti-Müllerian hormone (AMH) levels (ng/mL) and antral follicle count (AFC).
  
  
  RESULTS
  Patients in the lymphoma group demonstrated significantly lower AMH levels and AFC and had less oocytes harvested and cryopreserved when compared to healthy controls as well as patients with other malignancies.
  
  
  CONCLUSIONS
  Patients with lymphoma demonstrate diminished ovarian reserve when compared with healthy controls and patients with other malignancies. This should be taken into consideration when deciding on the dose for COH.
authors.affiliation: The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 1305 York Avenue, 6th floor, New York, NY, 10021, USA. jol9105@med.cornell.edu.
authors.forename: Jovana
authors.initials: J
authors.lastname: Lekovich
authors.affiliation: The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 1305 York Avenue, 6th floor, New York, NY, 10021, USA.
authors.forename: Alexandre L S
authors.initials: ALS
authors.lastname: Lobel
authors.affiliation: Department of Obstetrics and Gynecology, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Stewart
authors.affiliation: The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 1305 York Avenue, 6th floor, New York, NY, 10021, USA.
authors.forename: Nigel
authors.initials: N
authors.lastname: Pereira
authors.affiliation: The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 1305 York Avenue, 6th floor, New York, NY, 10021, USA.
authors.forename: Isaac
authors.initials: I
authors.lastname: Kligman
authors.affiliation: The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 1305 York Avenue, 6th floor, New York, NY, 10021, USA.
authors.forename: Zev
authors.initials: Z
authors.lastname: Rosenwaks
mesh_terms: D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015925:Cryopreservation; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D007247:Infertility, Female / Q000150:complications*; D008223:Lymphoma / Q000150:complications*; D065851:Ovarian Reserve; D010062:Ovulation Induction; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D054304:Anti-Mullerian Hormone
keywords: AMH; Lymphoma; Ovarian reserve