title: Comparison between resveratrol and cabergoline in preventing ovarian hyperstimulation syndrome in a rat model.
abstract: OBJECTIVE
  The aim of this study is to investigate the effects of resveratrol in a rat model of ovarian hyperstimulation syndrome (OHSS) and compare with cabergoline.
  
  
  METHODS
  Randomized controlled, animal study.
  
  
  METHODS
  Female Wistar rats.
  
  
  METHODS
  A rat OHSS model was used to investigate the effects of resveratrol compare with cabergoline administration for preventing OHSS. Body weight, ovary weight, diameter, vascular permeability (VP), vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2) expression (immunohistochemistry), and serum estradiol (E2) levels were then compared.
  
  
  RESULTS
  The ovarian VEGF concentration was significantly increased in the OHSS Groups (Groups 3-5) compared with the control groups (1 and 2). But vascular permeability, VEGF, and COX-2 expressions were reduced in animals treated with the resveratrol group compared with the cabergoline group (group 5) and the severe OHSS (group 3) group. Blood E2 levels were decreased in group treated with the resveratrol group compared with the cabergoline group (group 5) and severe the OHSS (group 3) group.
  
  
  CONCLUSIONS
  Our results in a rat model suggest that resveratrol has a beneficial effect on OHSS by reducing the increases in ovarian daimeter, VP, and VEGF expression associated with OHSS. These effects may be mediated by the COX-2 inhibitory capacity of resveratrol.
authors.affiliation: a Department of Obstetrics and Gynecology , Sifa University School of Medicine , İzmir , Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Kasap
authors.affiliation: a Department of Obstetrics and Gynecology , Sifa University School of Medicine , İzmir , Turkey.
authors.forename: Gülizar Arzu
authors.initials: GA
authors.lastname: Turan
authors.affiliation: b Department of Obstetrics and Gynecology , Merkez Efendi State Hospital , Manisa , Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Eskicioğlu
authors.affiliation: c Department of Biostatistics and Medical Informatics , Medical School, Sifa University, Izmir, Turkey Molecular Medicine, Institute of Health Science, Dokuz Eylül University , Inciralti , Izmir , Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Cengiz
authors.affiliation: a Department of Obstetrics and Gynecology , Sifa University School of Medicine , İzmir , Turkey.
authors.forename: Esra Bahar
authors.initials: EB
authors.lastname: Gur
authors.affiliation: d Department of Pathology , Sifa University School of Medicine , İzmir , Turkey , and.
authors.forename: Oya Nermin
authors.initials: ON
authors.lastname: Sivrikoz
authors.affiliation: a Department of Obstetrics and Gynecology , Sifa University School of Medicine , İzmir , Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Genc
authors.affiliation: e Department of Laboratory Animal Science , Dokuz Eylul University School of Medicine , İzmir , Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Yılmaz
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D000077465:Cabergoline; D004195:Disease Models, Animal; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D004873:Ergolines / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D010053:Ovary / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D018491:Dopamine Agonists; D004873:Ergolines; D013267:Stilbenes; D000077465:Cabergoline; D000077185:Resveratrol
keywords: Cabergoline; OHSS; rat model; resveratrol