title: INVESTIGATION OF PARTIAL VOLUME EFFECT IN DIFFERENT PET/CT SYSTEMS: A COMPARISON OF RESULTS USING THE MADEIRA PHANTOM AND THE NEMA NU-2 2001 PHANTOM.
abstract: Positron emission tomography combined with computed tomography (PET/CT) is a quantitative technique used for diagnosing various diseases and for monitoring treatment response for different types of tumours. However, the accuracy of the data is limited by the spatial resolution of the system. In addition, the so-called partial volume effect (PVE) causes a blurring of image structures, which in turn may cause an underestimation of activity of a structure with high-activity content. In this study, a new phantom, MADEIRA (Minimising Activity and Dose with Enhanced Image quality by Radiopharmaceutical Administrations) for activity quantification in PET and single photon emission computed tomography (SPECT) was used to investigate the influence on the PVE by lesion size and tumour-to-background activity concentration ratio (TBR) in four different PET/CT systems. These measurements were compared with data from measurements with the NEMA NU-2 2001 phantom. The results with the MADEIRA phantom showed that the activity concentration (AC) values were closest to the true values at low ratios of TBR (<10) and reduced to 50 % of the actual AC values at high TBR (30-35). For all scanners, recovery of true values became closer to 1 with an increasing diameter of the lesion. The MADEIRA phantom showed good agreement with the results obtained from measurements with the NEMA NU-2 2001 phantom but allows for a wider range of possibilities in measuring image quality parameters.
authors.affiliation: Research Institute of Radiation Hygiene, St. Petersburg, Russian Federation Federal Almazov North-West Medical Research Centre, St. Petersburg, Russian Federation larisa.chipiga@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Chipiga
authors.affiliation: Department of Radiation Physics, Skane University Hospital, Lund, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Sydoff
authors.affiliation: Research Institute of Radiation Hygiene, St. Petersburg, Russian Federation.
authors.forename: I
authors.initials: I
authors.lastname: Zvonova
authors.affiliation: Medical Radiation Physics, Department of Translational Medicine, Lund University, Skane University Hospital, Malmö, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Bernhardsson
mesh_terms: D016477:Artifacts; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D021621:Imaging, Three-Dimensional / Q000379:methods; D009369:Neoplasms / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D000072078:Positron Emission Tomography Computed Tomography / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D047368:Tumor Burden