title: Congenital varicella syndrome: A systematic review.
abstract: Varicella-zoster virus (VZV) is a teratogen that can cross the placenta and cause the congenital varicella syndrome (CVS), which is characterised by multi-system anomalies. There have been 130 reported cases of CVS from 1947 to 2013. The estimated incidence of CVS was 0.59% and 0.84% for women infected with VZV during the entire pregnancy and for those infected the first 20 weeks of pregnancy, respectively. Nine cases were reported at 21-27 weeks of gestation and one case was identified at 36 weeks. Herpes zoster caused CVS in two cases. Regarding treatment, varicella zoster immunoglobulin treatment, irrespective of gestational age, should be considered in addition to antiviral drugs for women who have been exposed to or infected with virus.
authors.affiliation: a Department of Obstetrics and Gynaecology , Korea University Anam Hospital, Korea University College of Medicine , Seoul , South Korea .
authors.forename: Ki Hoon
authors.initials: KH
authors.lastname: Ahn
authors.affiliation: a Department of Obstetrics and Gynaecology , Korea University Anam Hospital, Korea University College of Medicine , Seoul , South Korea .
authors.forename: Yun-Jung
authors.initials: YJ
authors.lastname: Park
authors.affiliation: a Department of Obstetrics and Gynaecology , Korea University Anam Hospital, Korea University College of Medicine , Seoul , South Korea .
authors.forename: Soon-Cheol
authors.initials: SC
authors.lastname: Hong
authors.affiliation: b Department of Paediatrics , Korea University College of Medicine , Seoul , South Korea , and.
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Lee
authors.affiliation: c Clinical Research Centre , Asan Medical Centre , Seoul , South Korea.
authors.forename: Ji-Sung
authors.initials: JS
authors.lastname: Lee
authors.affiliation: a Department of Obstetrics and Gynaecology , Korea University Anam Hospital, Korea University College of Medicine , Seoul , South Korea .
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Oh
authors.affiliation: a Department of Obstetrics and Gynaecology , Korea University Anam Hospital, Korea University College of Medicine , Seoul , South Korea .
authors.forename: Hai-Joong
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D002644:Chickenpox / Q000151:congenital* / Q000635:transmission / Q000821:virology; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology* / Q000821:virology; D005865:Gestational Age; D014645:Herpesvirus 3, Human; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data*; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000821:virology; D013577:Syndrome
keywords: Chickenpox; congenital varicella syndrome; herpes zoster; pregnancy