title: Role of signal peptide-Cub-Egf domain-containing protein-1 in serum as a predictive biomarker of outcome after severe traumatic brain injury.
abstract: BACKGROUND
  Signal peptide-Cub-Epidermal growth factor domain-containing protein 1 (SCUBE1), a marker for coagulation, is secreted under hypoxia and inflammatory conditions from platelet α granules. This study was designed to determine the associations of serum SCUBE1 concentrations with trauma severity and prognosis after severe traumatic brain injury.
  
  
  METHODS
  Serum SCUBE1 concentrations of 113 patients and 113 controls were measured. An unfavorable outcome was defined as Glasgow Outcome Scale score of 1-3.
  
  
  RESULTS
  Serum SCUBE1 concentrations were significantly higher in patients than in controls (15.5 ± 6.0 vs. 1.1 ± 0.3 ng/ml, P < 0.001) and were associated with Glasgow coma scale scores (r = -0.439, P < 0.001) and blood platelet count (r = 0.420, P < 0.001). SCUBE1 was identified as an independent prognostic marker of 6-month unfavorable outcome (odds ratio, 1.357; 95% confidence interval, 1.159-1.589; P < 0.001), and had high predictive value according to receiver operating characteristic curve (area under curve, 0.830; 95% confidence interval, 0.748-0.890; P < 0.001).
  
  
  CONCLUSIONS
  Increased serum SCUBE1 concentrations are associated highly with trauma severity, platelet activation and poor outcome, suggesting that SCUBE1 might be a novel prognostic biomarker after traumatic brain injury.
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Tonglu County, 338 Xuesheng Road, Tonglu 311500, China. Electronic address: hzffengchen@163.com.
authors.forename: Qi-Han
authors.initials: QH
authors.lastname: Chen
authors.affiliation: Department of Neurology, The First People's Hospital of Tonglu County, 338 Xuesheng Road, Tonglu 311500, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Lin
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Tonglu County, 338 Xuesheng Road, Tonglu 311500, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Tonglu County, 338 Xuesheng Road, Tonglu 311500, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Deng
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D000070642:Brain Injuries, Traumatic / Q000097:blood* / Q000175:diagnosis*; D002135:Calcium-Binding Proteins; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D011379:Prognosis
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D008565:Membrane Proteins; C469998:SCUBE1 protein, human
keywords: Biomarker; Platelet activation; Prognosis; Severity; Signal peptide-Cub-Epidermal growth factor domain-containing protein 1; Traumatic brain injury