title: Brief Report: Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection.
abstract: To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre- and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV-monoinfected and 22% for coinfected men. Decreases in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men.
authors.affiliation: *Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco, CA; †Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; ‡Division of Infectious Diseases, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL; §Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles Biomedical Research Institute, Harbor-UCLA, Torrance, CA; ‖Division of Infectious Diseases, Department of Medicine, Ohio State University, Columbus, OH; and ¶Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Price
authors.forename: Eric C
authors.initials: EC
authors.lastname: Seaberg
authors.forename: John P
authors.initials: JP
authors.lastname: Phair
authors.forename: Mallory D
authors.initials: MD
authors.lastname: Witt
authors.forename: Susan L
authors.initials: SL
authors.lastname: Koletar
authors.forename: Chloe L
authors.initials: CL
authors.lastname: Thio
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D023241:Antiretroviral Therapy, Highly Active; D001219:Aspartate Aminotransferases / Q000097:blood; D018791:CD4 Lymphocyte Count; D060085:Coinfection; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology*; D018451:Homosexuality, Male; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology* / Q000821:virology; D008107:Liver Diseases / Q000188:drug therapy* / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D008297:Male; D011446:Prospective Studies; D019562:Viral Load
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase