title: Cytokeratin 7-negative mammary Paget's disease: A diagnostic pitfall.
abstract: Pathologists should be aware of the existence of a rare CK7-negative variant of breast carcinoma in general, and of Paget's disease in particular. Cytokeratin 7-negative Paget's disease and CK7-negative ductal intraepithelial neoplasia (ductal carcinoma in situ) present a major diagnostic challenge for pathologists since there is limited awareness of their existence. When there is classic Paget's morphology on H&E sections, GATA3 positivity should resolve any doubts about the diagnosis in the setting of a CK7-negative neoplastic cell population.
authors.affiliation: Department of Pathology, Yale University School of Medicine, PO Box 208023, New Haven, CT 06520-8023, USA.
authors.forename: Ugur
authors.initials: U
authors.lastname: Ozerdem
authors.affiliation: Department of Pathology, Yale University School of Medicine, PO Box 208023, New Haven, CT 06520-8023, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: McNiff
authors.affiliation: Department of Pathology, Yale University School of Medicine, PO Box 208023, New Haven, CT 06520-8023, USA. Electronic address: fattaneh.tavassoli@yale.edu.
authors.forename: Fattaneh A
authors.initials: FA
authors.lastname: Tavassoli
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7 / Q000096:biosynthesis*; D008875:Middle Aged; D009558:Nipples / Q000378:metabolism / Q000473:pathology; D010144:Paget's Disease, Mammary / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D053552:Keratin-7
keywords: Breast; CK7; Cancer; GATA3; Paget's disease