title: Invasive Breast Cancer Version 1.2016, NCCN Clinical Practice Guidelines in Oncology.
abstract: Breast cancer is the most common malignancy in women in the United States and is second only to lung cancer as a cause of cancer death. The overall management of breast cancer includes the treatment of local disease with surgery, radiation therapy, or both, and the treatment of systemic disease with cytotoxic chemotherapy, endocrine therapy, biologic therapy, or combinations of these. This article outlines the NCCN Guidelines specific to breast cancer that is locoregional (restricted to one region of the body), and discusses the management of clinical stage I, II, and IIIA (T3N1M0) tumors. For NCCN Guidelines on systemic adjuvant therapy after locoregional management of clinical stage I, II and IIIA (T3N1M0) and for management for other clinical stages of breast cancer, see the complete version of these guidelines at NCCN.org.
authors.forename: William J
authors.initials: WJ
authors.lastname: Gradishar
authors.forename: Benjamin O
authors.initials: BO
authors.lastname: Anderson
authors.forename: Ron
authors.initials: R
authors.lastname: Balassanian
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Blair
authors.forename: Harold J
authors.initials: HJ
authors.lastname: Burstein
authors.forename: Amy
authors.initials: A
authors.lastname: Cyr
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Elias
authors.forename: William B
authors.initials: WB
authors.lastname: Farrar
authors.forename: Andres
authors.initials: A
authors.lastname: Forero
authors.forename: Sharon Hermes
authors.initials: SH
authors.lastname: Giordano
authors.forename: Matthew
authors.initials: M
authors.lastname: Goetz
authors.forename: Lori J
authors.initials: LJ
authors.lastname: Goldstein
authors.forename: Clifford A
authors.initials: CA
authors.lastname: Hudis
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Isakoff
authors.forename: P Kelly
authors.initials: PK
authors.lastname: Marcom
authors.forename: Ingrid A
authors.initials: IA
authors.lastname: Mayer
authors.forename: Beryl
authors.initials: B
authors.lastname: McCormick
authors.forename: Meena
authors.initials: M
authors.lastname: Moran
authors.forename: Sameer A
authors.initials: SA
authors.lastname: Patel
authors.forename: Lori J
authors.initials: LJ
authors.lastname: Pierce
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Reed
authors.forename: Kilian E
authors.initials: KE
authors.lastname: Salerno
authors.forename: Lee S
authors.initials: LS
authors.lastname: Schwartzberg
authors.forename: Karen Lisa
authors.initials: KL
authors.lastname: Smith
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Smith
authors.forename: Hatem
authors.initials: H
authors.lastname: Soliman
authors.forename: George
authors.initials: G
authors.lastname: Somlo
authors.forename: Melinda
authors.initials: M
authors.lastname: Telli
authors.forename: John H
authors.initials: JH
authors.lastname: Ward
authors.forename: Dorothy A
authors.initials: DA
authors.lastname: Shead
authors.forename: Rashmi
authors.initials: R
authors.lastname: Kumar
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D003131:Combined Modality Therapy; D005260:Female; D005298:Fertility / Q000187:drug effects; D059247:Fertility Preservation; D006801:Humans; D016462:Mammaplasty / Q000379:methods; D008408:Mastectomy / Q000379:methods; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D014481:United States