title: Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat.
abstract: OBJECTIVE
  To investigate the role of adenosine A2A receptors on 6-OHDA-induced motor disorder in rat.
  
  
  METHODS
  In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three weeks as a recovery period, 6-OHDA-induced bradykinesia and balance disturbances were assessed by using beam traversal test 10, 30 and 60 minutes after intraperitoneal injections of the drugs (caffeine, SCH58261).
  
  
  RESULTS
  The results showed that 6-OHDA (8 μg/rat, Intra-SNc) induced motor disorders of Parkinson's disease and increased elapsed time in the beam test (p<0.001). Injection of caffeine (30 mg/kg, i.p.) and SCH58261 (2 mg/kg, i.p.) attenuated elapsed time on beam (p<0.01 and p<0.001). We showed that acute administration of caffeine and SCH 58261 can improve the 6-OHDA-induced bradykinesia and motor disturbance.
  
  
  CONCLUSIONS
  Adenosine A2AR antagonists improve 6-OHDA-motor deficit and this effect seems to be mediated by the inhibition of A2A presynaptic receptors in substantia nigra pars compacta.
authors.affiliation: Department of Laboratory Sciences, Islamic Azad University, Marand, Iran.
authors.forename: Siamak
authors.initials: S
authors.lastname: Reyhani-Rad
authors.affiliation: Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Mahmoudi
mesh_terms: D058917:Adenosine A2 Receptor Antagonists / Q000494:pharmacology*; D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D004195:Disease Models, Animal; D018476:Hypokinesia / Q000139:chemically induced; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D000068079:Motor Disorders / Q000139:chemically induced; D016627:Oxidopamine / Q000009:adverse effects*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D058915:Purinergic P1 Receptor Antagonists / Q000494:pharmacology*; D017208:Rats, Wistar; D013996:Time and Motion Studies
chemical_list: D058917:Adenosine A2 Receptor Antagonists; D058915:Purinergic P1 Receptor Antagonists; D002110:Caffeine; D016627:Oxidopamine