title: Plasma apolipoprotein C1 concentration is associated with plasma triglyceride concentration, but not visceral fat, in patients with type 2 diabetes.
abstract: BACKGROUND
  Apolipoprotein C1 (apoC1) is likely to play an important role in triglyceride (TG) metabolism. Mice overexpressing human apoC1 present decreased adipose tissue stores. This study aimed to determine whether apoC1 concentration influences fat mass and distribution and liver fat content (LFC) in patients with type 2 diabetes (T2D).
  
  
  METHODS
  ApoC1 concentrations were measured by ELISA in 113 T2D patients and 56 normolipidaemic-normoglycaemic subjects. Visceral and subcutaneous fat areas were determined by single-slice axial T1-weighted magnetic resonance imaging (MRI), while LFC was measured by hydrogen-1 ((1)H) MR spectroscopy.
  
  
  RESULTS
  ApoC1 concentrations were higher in T2D patients than in normolipidaemic-normoglycaemic subjects (P<0.0001), and did not correlate with visceral or subcutaneous fat areas, but significantly correlated with TG (P<0.0001) and LFC (P=0.02) in T2D patients. However, the correlation between apoC1 and LFC was lost after adjusting for TG. ApoC1 concentration was also significantly higher in T2D patients with TG<1.5mmol/L than in control subjects (P<0.0001), although both groups had similar TG levels. On multivariate analysis performed in T2D patients with TG<1.5mmol/L and control subjects, apoC1 concentration was independently and positively associated with type 2 diabetes (P<0.0001) and TG levels (P=0.03).
  
  
  CONCLUSIONS
  This study reports, for the first time, that apoC1 is increased in T2D patients and is significantly correlated with TG, whereas no association was found between apoC1 and adipose tissue. This indicates that, in T2D, apoC1 may play a role in TG metabolism, but is unlikely to modulate fat mass and distribution. This increased apoC1 concentration in T2D patients is not only explained by the increased TG level in T2D patients.
authors.affiliation: Endocrinology, Diabetology department, University Hospital of Dijon, 2, boulevard du Maréchal-de-Lattre-de-Tassigny, BP 77908, 21079 Dijon, France; INSERM UMR 866, University of Bourgogne, Dijon, France. Electronic address: benjamin.bouillet@chu-dijon.fr.
authors.forename: B
authors.initials: B
authors.lastname: Bouillet
authors.affiliation: INSERM UMR 866, University of Bourgogne, Dijon, France.
authors.forename: T
authors.initials: T
authors.lastname: Gautier
authors.affiliation: Epidemiology department, University Hospital of Dijon, 2, boulevard du Maréchal-de-Lattre-de-Tassigny, BP 77908, 21079 Dijon, France.
authors.forename: L S
authors.initials: LS
authors.lastname: Aho
authors.affiliation: INSERM UMR 866, University of Bourgogne, Dijon, France.
authors.forename: L
authors.initials: L
authors.lastname: Duvillard
authors.affiliation: Endocrinology, Diabetology department, University Hospital of Dijon, 2, boulevard du Maréchal-de-Lattre-de-Tassigny, BP 77908, 21079 Dijon, France; INSERM UMR 866, University of Bourgogne, Dijon, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Petit
authors.affiliation: INSERM UMR 866, University of Bourgogne, Dijon, France.
authors.forename: L
authors.initials: L
authors.lastname: Lagrost
authors.affiliation: Endocrinology, Diabetology department, University Hospital of Dijon, 2, boulevard du Maréchal-de-Lattre-de-Tassigny, BP 77908, 21079 Dijon, France; INSERM UMR 866, University of Bourgogne, Dijon, France.
authors.forename: B
authors.initials: B
authors.lastname: Vergès
mesh_terms: D050154:Adiposity; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053302:Apolipoprotein C-I / Q000097:blood*; D050218:Body Fat Distribution; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism / Q000473:pathology*; D050356:Lipid Metabolism / Q000502:physiology; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D053302:Apolipoprotein C-I; D014280:Triglycerides
keywords: Apolipoprotein C1; Liver fat content; Triglycerides; Type 2 diabetes; Visceral fat