title: Mitochondria in pluripotent stem cells: stemness regulators and disease targets.
abstract: Beyond their canonical role in efficient ATP production through oxidative metabolism, mitochondria are increasingly recognized as critical in defining stem cell function and fate. Implicating a fundamental interplay within the epigenetics of eukaryotic cell systems, the integrity of mitochondria is found vital across the developmental/differentiation spectrum from securing pluripotency maintenance to informing organotypic decisions. This overview will discuss recent progress on examining the plasticity of mitochondria in enabling the execution of programming and reprogramming regimens, as well as the application of nuclear reprogramming and somatic cell nuclear transfer as rescue techniques to generate genetically and functionally corrected pluripotent stem cells from patients with mitochondrial DNA-based disease.
authors.affiliation: Center for Regenerative Medicine, Mayo Clinic, Rochester, MN 55905, USA; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Clifford Dl
authors.initials: CD
authors.lastname: Folmes
authors.affiliation: Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Ma
authors.affiliation: Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Electronic address: mitalipo@oshu.edu.
authors.forename: Shoukhrat
authors.initials: S
authors.lastname: Mitalipov
authors.affiliation: Center for Regenerative Medicine, Mayo Clinic, Rochester, MN 55905, USA; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: terzic.andre@mayo.edu.
authors.forename: Andre
authors.initials: A
authors.lastname: Terzic
mesh_terms: D000066670:Cell Plasticity / Q000235:genetics; D065150:Cellular Reprogramming / Q000235:genetics*; D057890:Epigenomics; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D028361:Mitochondrial Diseases / Q000235:genetics* / Q000628:therapy; D053652:Nuclear Transfer Techniques; D039904:Pluripotent Stem Cells