title: Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons.
abstract: Inhibitory neurons regulate the adaptation of neural circuits to sensory experience, but the molecular mechanisms by which experience controls the connectivity between different types of inhibitory neuron to regulate cortical plasticity are largely unknown. Here we show that exposure of dark-housed mice to light induces a gene program in cortical vasoactive intestinal peptide (VIP)-expressing neurons that is markedly distinct from that induced in excitatory neurons and other subtypes of inhibitory neuron. We identify Igf1 as one of several activity-regulated genes that are specific to VIP neurons, and demonstrate that IGF1 functions cell-autonomously in VIP neurons to increase inhibitory synaptic input onto these neurons. Our findings further suggest that in cortical VIP neurons, experience-dependent gene transcription regulates visual acuity by activating the expression of IGF1, thus promoting the inhibition of disinhibitory neurons and affecting inhibition onto cortical pyramidal neurons.
authors.affiliation: Department of Molecular and Cellular Biology, University of California Berkeley, 205 Life Sciences Addition, Berkeley, California 94720, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Mardinly
authors.affiliation: Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA.
authors.forename: I
authors.initials: I
authors.lastname: Spiegel
authors.affiliation: FM Kirby Neurobiology Center, Boston Children's Hospital, 3 Blackfan Circle, Boston, Massachusetts 02115, USA.
authors.forename: A
authors.initials: A
authors.lastname: Patrizi
authors.affiliation: FM Kirby Neurobiology Center, Boston Children's Hospital, 3 Blackfan Circle, Boston, Massachusetts 02115, USA.
authors.forename: E
authors.initials: E
authors.lastname: Centofante
authors.affiliation: Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Bazinet
authors.affiliation: Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA.
authors.forename: C P
authors.initials: CP
authors.lastname: Tzeng
authors.affiliation: Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA.
authors.forename: C
authors.initials: C
authors.lastname: Mandel-Brehm
authors.affiliation: Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Harmin
authors.affiliation: Department of Molecular and Cellular Biology, University of California Berkeley, 205 Life Sciences Addition, Berkeley, California 94720, USA.
authors.forename: H
authors.initials: H
authors.lastname: Adesnik
authors.affiliation: FM Kirby Neurobiology Center, Boston Children's Hospital, 3 Blackfan Circle, Boston, Massachusetts 02115, USA.
authors.forename: M
authors.initials: M
authors.lastname: Fagiolini
authors.affiliation: Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Greenberg
mesh_terms: D000818:Animals; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009433:Neural Inhibition; D009434:Neural Pathways; D009473:Neuronal Plasticity; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D017966:Pyramidal Cells / Q000378:metabolism; D013569:Synapses / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*; D014785:Vision, Ocular / Q000502:physiology; D014793:Visual Cortex / Q000166:cytology* / Q000502:physiology*
chemical_list: C519530:insulin-like growth factor-1, mouse; D014660:Vasoactive Intestinal Peptide; D007334:Insulin-Like Growth Factor I