title: [Use of a novel polymer, the in-situ gelling mucoadhesive thiolated poly(aspartic acid) in ophthalmic drug delivery].
abstract: The bioavailability of drugs used on mucosal surfaces can be increased by the use of mucoadhesive polymers. A new type of mucoadhesive polymers is the group of thiolated polymers with thiol group containing side chains. These polymers are able to form covalent bonds (disulphide linkages) with the mucin glycoproteins. For the formulation of an ocular drug delivery system (DDS) thiolated poly(aspartic acid) polymer (ThioPASP) was used. Our aim was to determine their biocompatibility, mucoadhesion and drug release property. According to the results it can be established that the thiolated poly(aspartic acid) polymers can be a potential vehicle of an ocular drug delivery system due to their biocompatibility, good mucoadhesive property and drug release profile. Thanks to their properties controlled drug delivery can be achieved and bioavailability of the ophthalmic formulation can be increased, while the usage frequency can be decreased.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Horvát
authors.forename: Mária
authors.initials: M
authors.lastname: Budai-Szűcs
authors.forename: Szilvia
authors.initials: S
authors.lastname: Berkó
authors.forename: Piroska
authors.initials: P
authors.lastname: Szabóné-Révész
authors.forename: Benjámin
authors.initials: B
authors.lastname: Gyarmati
authors.forename: Barnabas Áron
authors.initials: BÁ
authors.lastname: Szilágyi
authors.forename: András
authors.initials: A
authors.lastname: Szilágyi
authors.lastname: Csányi Erzsébet
mesh_terms: D000268:Adhesiveness; D001224:Aspartic Acid / Q000008:administration & dosage; D001682:Biological Availability; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry / Q000494:pharmacology; D005128:Eye Diseases / Q000188:drug therapy; D005782:Gels; D006801:Humans; D009092:Mucous Membrane; D009883:Ophthalmic Solutions / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012212:Rheology; D013438:Sulfhydryl Compounds
chemical_list: D005079:Excipients; D005782:Gels; D009883:Ophthalmic Solutions; D011108:Polymers; D013438:Sulfhydryl Compounds; D001224:Aspartic Acid