title: Controlled Release of Ciprofloxacin from Core-Shell Nanofibers with Monolithic or Blended Core.
abstract: Sustained controlled drug release is one of the prominent contributions for more successful treatment outcomes in the case of several diseases. However, the incorporation of hydrophilic drugs into nanofibers, a promising novel delivery system, and achieving a long-term sustained release still pose a challenging task. In this work we demonstrated a robust method of avoiding burst release of drugs and achieving a sustained drug release from 2 to 4 weeks using core-shell nanofibers with poly(methyl methacrylate) (PMMA) shell and monolithic poly(vinyl alcohol) (PVA) core or a novel type of core-shell nanofibers with blended (PVA and PMMA) core loaded with ciprofloxacin hydrochloride (CIP). It is also shown that, for core-shell nanofibers with monolithic core, drug release can be manipulated by varying flow rate of the core PVA solution, whereas for core-shell nanofibers with blended core, drug release can be manipulated by varying the ratios between PMMA and PVA in the core. During coaxial electrospinning, when the solvent from the core evaporates in concert with the solvent from the shell, the interconnected pores spanning the core and the shell are formed. The release process is found to be desorption-limited and agrees with the two-stage desorption model. Ciprofloxacin-loaded nanofiber mats developed in the present work could be potentially used as local drug delivery systems for treatment of several medical conditions, including periodontal disease and skin, bone, and joint infections.
authors.affiliation: Department of Mechanical and Industrial Engineering, University of Illinois at Chicago , Chicago, Illinois 60607-7022, United States.|Faculty of Pharmacy, University of Ljubljana , Aškerčeva 7, 1000 Ljubljana, Slovenia.
authors.forename: Špela
authors.initials: Š
authors.lastname: Zupančič
authors.affiliation: Department of Mechanical and Industrial Engineering, University of Illinois at Chicago , Chicago, Illinois 60607-7022, United States.
authors.forename: Sumit
authors.initials: S
authors.lastname: Sinha-Ray
authors.affiliation: Department of Mechanical and Industrial Engineering, University of Illinois at Chicago , Chicago, Illinois 60607-7022, United States.|Corporate Innovation Center, United States Gypsum , 700 US 45N, Libertyville, Illinois 60048, United States.|Department of Materials Science and Engineering, Indian Institute of Technology , Indore, Madhya Pradesh 452017, India.
authors.forename: Suman
authors.initials: S
authors.lastname: Sinha-Ray
authors.affiliation: Faculty of Pharmacy, University of Ljubljana , Aškerčeva 7, 1000 Ljubljana, Slovenia.
authors.forename: Julijana
authors.initials: J
authors.lastname: Kristl
authors.affiliation: Department of Mechanical and Industrial Engineering, University of Illinois at Chicago , Chicago, Illinois 60607-7022, United States.|College of Engineering, Korea University , Seoul, South Korea.
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Yarin
mesh_terms: D002939:Ciprofloxacin / Q000737:chemistry*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods*; D057927:Hydrophobic and Hydrophilic Interactions; D057139:Nanofibers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D003692:Delayed-Action Preparations; D002939:Ciprofloxacin
keywords: antibiotic; ciprofloxacin hydrochloride; coaxial electrospinning; core−shell nanofibers; phase separation; sustained drug release