title: The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity.
abstract: We have shown that melanoma-derived factors alter the function of differentiated tissue-resident dendritic cells (DC) in a tumorigenicity-dependent manner. Soluble factors, including TGFβ1 and VEGF-A, contributed to dendritic cell dysfunction associated with a highly-aggressive melanoma and conferred a phenotype upon DC likely to favor immune escape and tumor outgrowth.
authors.affiliation: Hargadon Laboratory, Department of Biology, Hampden-Sydney College , Hampden-Sydney, VA, USA.
authors.forename: Kristian Michael
authors.initials: KM
authors.lastname: Hargadon
keywords: Dendritic cells; dysfunction; immune regulation; melanoma; tumor; tumor-associated macrophages