title: Significance of high-normal blood pressure during early second trimester for predicting the onset of hypertensive disorders in pregnancy.
abstract: OBJECTIVE
  The aim of this study was to determine the predictive value of high-normal blood pressure (HNBP) during the early second trimester for hypertensive disorders in pregnancy, including gestational hypertension (GH) and preeclampsia (PE).
  
  
  METHODS
  This was a retrospective single-center cohort study of 2143 singleton pregnant women. The association of HNBP, ranging from 130/85 to 139/89 mmHg between 14 and 19 weeks of gestation, with the development of hypertensive disorders was assessed by multivariable logistic regression analyses.
  
  
  RESULTS
  In a cohort of 2102 pregnant women, 93 (4.4%) pregnancies had HNBP during early second trimester. Pregnant women with HNBP more frequently developed hypertensive disorders than normotensive women (20.4% vs. 8.2%, p < 0.001). HNBP was significantly associated with the development of GH (adjusted odds ratio (aOR): 1.81; 95% confidence interval (CI): 1.16-3.25, p = 0.015) and PE (aOR: 6.05; 95% CI: 3.46-12.6, p = 0.013) after adjustment for confounders.
  
  
  CONCLUSIONS
  HNBP during the early second trimester is an independent risk factor for both GH and PE.
authors.affiliation: a Department of Obstetrics, Osaka Medical Center and Research Institute for Maternal and Child Health , Murodochou, Izumi, Osaka , Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Mabuchi
authors.affiliation: a Department of Obstetrics, Osaka Medical Center and Research Institute for Maternal and Child Health , Murodochou, Izumi, Osaka , Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Yamamoto
authors.affiliation: a Department of Obstetrics, Osaka Medical Center and Research Institute for Maternal and Child Health , Murodochou, Izumi, Osaka , Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ishii
authors.affiliation: a Department of Obstetrics, Osaka Medical Center and Research Institute for Maternal and Child Health , Murodochou, Izumi, Osaka , Japan.
authors.forename: Reisa
authors.initials: R
authors.lastname: Kakubari
authors.affiliation: a Department of Obstetrics, Osaka Medical Center and Research Institute for Maternal and Child Health , Murodochou, Izumi, Osaka , Japan.
authors.forename: Sachi
authors.initials: S
authors.lastname: Takaoka
authors.affiliation: a Department of Obstetrics, Osaka Medical Center and Research Institute for Maternal and Child Health , Murodochou, Izumi, Osaka , Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Muto
authors.affiliation: a Department of Obstetrics, Osaka Medical Center and Research Institute for Maternal and Child Health , Murodochou, Izumi, Osaka , Japan.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Mitsuda
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000175:diagnosis* / Q000503:physiopathology; D008875:Middle Aged; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000502:physiology*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Early second trimester; gestational hypertension; high-normal blood pressure; preeclampsia