title: Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation.
abstract: Nrf1 (also referred to as NFE2L1) is a member of the CNC-bZIP family of transcription factors that are characterized by a highly conserved CNC-domain, and a basic-leucine zipper domain required for dimerization and DNA binding. Nrf1 is ubiquitously expressed across tissue and cell types as various isoforms, and is induced by stress signals from a broad spectrum of stimuli. Evidence indicates that Nrf1 plays an important role in regulating a range of cellular functions including oxidative stress response, differentiation, inflammatory response, metabolism, and maintaining proteostasis. Thus, Nrf1 has been implicated in the pathogenesis of various disease processes including cancer development, and degenerative and metabolic disorders. This review summarizes our current understanding of Nrf1 and the molecular mechanism underlying its regulation and action in different cellular functions.
authors.affiliation: Department of Laboratory Medicine and Pathology, University of California, Irvine, D440 Medical Sciences, Irvine, CA 92697, USA.
authors.forename: Hyun Min
authors.initials: HM
authors.lastname: Kim
authors.affiliation: Department of Laboratory Medicine and Pathology, University of California, Irvine, D440 Medical Sciences, Irvine, CA 92697, USA.
authors.forename: Jeong Woo
authors.initials: JW
authors.lastname: Han
authors.affiliation: Department of Laboratory Medicine and Pathology, University of California, Irvine, D440 Medical Sciences, Irvine, CA 92697, USA. Electronic address: jchan@uci.edu.
authors.forename: Jefferson Y
authors.initials: JY
authors.lastname: Chan
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D051265:NF-E2-Related Factor 1 / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D011487:Protein Conformation
chemical_list: D051265:NF-E2-Related Factor 1
keywords: Antioxidant; Antioxidant response element; CNC-bZIP; Cellular stress response; Proteostasis; Transcription factor; proteasome regulation