title: Serum NT-proBNP Levels Are Not Related to Vitamin D Status in Young Patients with Congenital Heart Defects.
abstract: BACKGROUND
  Hypovitaminosis D frequently occurs in early life and increases with age. Vitamin D has been suggested to influence cardiac performance and N-terminal-pro-type B natriuretic peptide (NT-proBNP) release in adults with heart failure.
  
  
  OBJECTIVE
  To assess the vitamin D status and the impact of hypovitaminosis D on circulating NT-proBNP levels in young patients with congenital heart defects (CHD).
  
  
  METHODS
  This cross-sectional study included the assessment of serum 25-hydroxyvitamin D (25OHD), parathyroid function markers, and NT-proBNP levels in a series of 230 young in-patients (117 females, 113 males; 6.4 (4.0-9.1) years (median, interquartile range)) with CHD.
  
  
  RESULTS
  Serum 25OHD levels <20 ng/mL were detected in 55.3% of patients. Optimal 25OHD levels (>30 ng/mL) occurred in 25% of patients. Serum 25OHD levels inversely correlated with age (r = -0.169, P = 0.013) and height standard deviation score (r = -0.269, P = 0.001). After correction for age, 25OHD negatively correlated with serum PTH levels (β = -0.200, P = 0.002). PTH levels above the upper quartile (44 pg/mL) occurred in 32% of hypovitaminosis D patients. Serum NT-proBNP levels were not correlated with 25OHD and PTH levels.
  
  
  CONCLUSIONS
  Half of the young CHD patients were diagnosed with 25OHD deficiency and a third of hypovitaminosis D patients experienced hyperparathyroidism. Nonetheless, serum NT-proBNP levels were not associated with hypovitaminosis D as well as hyperparathyroidism.
authors.affiliation: Endocrinology Unit, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Passeri
authors.affiliation: Laboratorio di Chimica Clinica, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Rigolini
authors.affiliation: Laboratorio di Chimica Clinica, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Costa
authors.affiliation: Laboratory of Molecular Biology, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Verdelli
authors.affiliation: Pediatric Cardiosurgery, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Arcidiacono
authors.affiliation: Pediatric Cardiosurgery, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Carminati
authors.affiliation: Endocrinology Unit, Department of Biomedical Sciences for Health, University of Milan, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Corbetta
mesh_terms: D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications / Q000378:metabolism*; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood; D010446:Peptide Fragments / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D010281:Parathyroid Hormone; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D014807:Vitamin D; C104450:25-hydroxyvitamin D