title: Clinical monitoring of smooth surface enamel lesions using CP-OCT during nonsurgical intervention.
abstract: Studies have shown that cross-polarization optical coherence tomography (CP-OCT) can be used to image the internal structure of carious lesions in vivo. The objective of this study was to show that CP-OCT can be used to monitor changes in the internal structure of early active carious lesions on smooth surfaces during non-surgical intervention with fluoride.
  
  
  
  Lesions on the smooth surfaces of teeth were imaged using CP-OCT on 17 test subjects. Lesion structural changes were monitored during fluoride varnish application at 6-week intervals for 30 weeks. The lesion depth (Ld), integrated reflectivity (ΔR), and surface zone thickness (Sz) were monitored.
  
  
  
  A distinct transparent surface zone that may be indicative of lesion arrestment was visible in CP-OCT images on 62/63 lesions before application of fluoride varnish. The lesion depth and internal structure were resolved for all the lesions. The overall change in the mean values for Ld, ΔR, and Szfor all the lesions was minimal and was not significant during the study (P > 0.05). Only 5/63 lesions manifested a significant increase in Szduring intervention.
  
  
  
  Even though it appears that most of the lesions manifested little change with fluoride varnish application in the 30 weeks of the study, CP-OCT was able to measure the depth and internal structure of all the lesions including the thickness of the important transparent surface zone located at the surface of the lesions, indicating that CP-OCT is ideally suited for monitoring lesion severity in vivo. Lasers Surg. Med. 48:915-923, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: University of California, San Francisco, San Francisco, California, 94143-0758.
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Chan
authors.affiliation: University of California, San Francisco, San Francisco, California, 94143-0758.
authors.forename: Henry
authors.initials: H
authors.lastname: Tom
authors.affiliation: University of California, San Francisco, San Francisco, California, 94143-0758.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Lee
authors.affiliation: University of California, San Francisco, San Francisco, California, 94143-0758.
authors.forename: Hobin
authors.initials: H
authors.lastname: Kang
authors.affiliation: University of California, San Francisco, San Francisco, California, 94143-0758.
authors.forename: Jacob C
authors.initials: JC
authors.lastname: Simon
authors.affiliation: University of California, San Francisco, San Francisco, California, 94143-0758.
authors.forename: Michal
authors.initials: M
authors.lastname: Staninec
authors.affiliation: University of California, San Francisco, San Francisco, California, 94143-0758.
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Darling
authors.affiliation: University of California, San Francisco, San Francisco, California, 94143-0758.
authors.forename: Roger B
authors.initials: RB
authors.lastname: Pelzner
authors.affiliation: University of California, San Francisco, San Francisco, California, 94143-0758.
authors.forename: Daniel
authors.initials: D
authors.lastname: Fried
mesh_terms: D000293:Adolescent; D000328:Adult; D002327:Cariostatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003731:Dental Caries / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D003743:Dental Enamel / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000473:pathology; D004334:Drug Administration Schedule; D005260:Female; D005460:Fluorides, Topical / Q000494:pharmacology / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical
keywords: cross polarization optical coherence tomography; dental caries; tooth demineralization