title: The diagnostic accuracy of rapid urease biopsy test compared to histopathology in implementing "test and treat" policy for Helicobacter pylori.
abstract: BACKGROUND
  Helicobacter pylori is one of the most important causes of the varied spectrum of gastroduodenal diseases. It is important to have a rapid diagnostic method to detect the organism so as to initiate the treatment early and check its progression to malignancy.
  
  
  OBJECTIVE
  To evaluate the diagnostic accuracy of rapid urease biopsy test in detecting H. pylori infection and implementation of "test and treat" policy.
  
  
  METHODS
  All patients of chronic dyspepsia not responding to conventional treatment were subjected to endoscopy, and mucosal biopsy samples were collected. A rapid urease test (RUT) and histopathology was performed on these samples and taking histopathology as gold standard for H. pylori demonstration, the diagnostic accuracy of RUT was evaluated.
  
  
  RESULTS
  The specificity, sensitivity, positive predictive value, negative predictive value, and diagnostic accuracy of RUT were 97.22%, 94.04%, 98.75%, 87.5%, and 95%, respectively.
  
  
  CONCLUSIONS
  Use of a rapid diagnostic test viz., rapid urease biopsy test to confirm H. pylori infection is recommended for early diagnosis and treatment of H. pylori associated gastroduodenal diseases.
authors.affiliation: Department of Pathology, IQ City Medical College, Durgapur, West Bengal, India.
authors.forename: Asitava Deb
authors.initials: AD
authors.lastname: Roy
authors.affiliation: Department of Pathology, Gauhati Medical College, Guwahati, Assam, India.
authors.forename: Swapna
authors.initials: S
authors.lastname: Deuri
authors.affiliation: Department of Pathology, Gauhati Medical College, Guwahati, Assam, India.
authors.forename: Umesh Chandra
authors.initials: UC
authors.lastname: Dutta
keywords: Diagnosis; Helicobacter pylori; histopathology; urease test