title: A pilot study of gestational diabetes mellitus not controlled by diet alone: First-line medical treatment with myoinositol may limit the need for insulin.
abstract: OBJECTIVE
  This study assessed whether myoinositol might be a first-line medical treatment for gestational diabetes mellitus (GDM).
  
  
  METHODS
  For 12 months, women with GDM not controlled by diet (n=32) were prospectively treated with myoinositol 1200mg and folic acid 400μg/day, while consecutive women (n=28) with insulin-requiring GDM treated during the previous year at our centre constituted the control group. Baseline characteristics and care were similar in both groups.
  
  
  RESULTS
  Insulin was required in eight women (25%) in the myoinositol group who, compared with the 24 who did not need insulin, were older (37±5 vs. 32±5 years, respectively; P=0.018) and had a larger percentage of high self-monitored glucose values (45±8% vs. 32±14%; P<0.0001) during the week prior to the introduction of myoinositol treatment. All of the women had similar pregnancy outcomes regardless of their GDM management, although less labour induction was required in the myoinositol group (OR: 0.22 [0.07-0.65]), which had no side effects.
  
  
  CONCLUSIONS
  This pilot study suggests that myoinositol may be a safe first-line medical treatment for uncontrolled GDM.
authors.affiliation: Maternité, Clinique de l'Étoile, 13100 Aix-en-Provence, France. Electronic address: vanessa.lubin@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Lubin
authors.affiliation: Maternité, Clinique de l'Étoile, 13100 Aix-en-Provence, France.
authors.forename: R
authors.initials: R
authors.lastname: Shojai
authors.affiliation: Pôle ENDO, CHU La Conception, AP-HM, INRA, UMR 1260, Inserm, UMR 1062, Nutrition, Obésité et Risque Thrombotique, Aix-Marseille Université, Faculté de Médecine, 13385 Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Darmon
authors.affiliation: Paris-Nord University, CRNH-IdF, CINFO, 93140 Bondy, France; UMR U1153 Inserm/U11125 Inra/CNAM/Université Paris13, Unité de Recherche Épidémiologique Nutritionnelle, 93000 Bobigny, France.
authors.forename: E
authors.initials: E
authors.lastname: Cosson
mesh_terms: D000328:Adult; D015190:Blood Glucose Self-Monitoring; D003131:Combined Modality Therapy; D016640:Diabetes, Gestational / Q000097:blood / Q000178:diet therapy* / Q000188:drug therapy*; D004032:Diet; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D005602:France; D006801:Humans; D007294:Inositol / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D010865:Pilot Projects; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D007328:Insulin; D007294:Inositol; D005492:Folic Acid
keywords: Diabetes; Gestational diabetes mellitus; Insulin; Macrosomia; Myoinositol; Pregnancy