title: Prosthetic heart valve selection in women of childbearing age with acquired heart disease: a case report.
abstract: BACKGROUND
  The problem of prosthetic heart valve selection in fertile women with acquired heart defects remains crucial in modern cardiology. Mechanical heart valves require lifelong indirect anticoagulant therapy, which has significant fetal toxicity and is unacceptable for women planning pregnancy. Bioprosthetic heart valves are the best choice for fertile women; however, their durability is limited, and reoperations are required.
  
  
  METHODS
  We describe the clinical case of a 21-year-old Russian woman with infectious endocarditis who underwent heart valve replacement with an epoxy-treated mitral valve prosthesis.
  
  
  CONCLUSIONS
  Epoxy-treated bioprosthetic heart valves can be used without long-term anticoagulant therapy because of their optimal hemodynamic functional parameters. Moreover, their high thromboresistance and resistance to infection improve patients' quality of life in their late postoperative period. We recommend these valves both in older persons and in young patients including women who are planning pregnancy.
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd., 6, Kemerovo, 650002, Russian Federation. bls14@yandex.ru.
authors.forename: Leonid
authors.initials: L
authors.lastname: Barbarash
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd., 6, Kemerovo, 650002, Russian Federation. wenys@mail.ru.
authors.forename: Natalya
authors.initials: N
authors.lastname: Rutkovskaya
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd., 6, Kemerovo, 650002, Russian Federation. barb61@yandex.ru.
authors.forename: Olga
authors.initials: O
authors.lastname: Barbarash
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd., 6, Kemerovo, 650002, Russian Federation. odarun3@mail.ru.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Odarenko
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd., 6, Kemerovo, 650002, Russian Federation. astasev@gmail.com.
authors.forename: Alexander
authors.initials: A
authors.lastname: Stasev
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd., 6, Kemerovo, 650002, Russian Federation. evg.uchasova@yandex.ru.
authors.forename: Evgenya
authors.initials: E
authors.lastname: Uchasova
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000925:Anticoagulants / Q000008:administration & dosage; D002443:Ceftriaxone / Q000008:administration & dosage*; D002585:Cesarean Section; D004696:Endocarditis / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005298:Fertility; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008943:Mitral Valve / Q000473:pathology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D011256:Pregnancy Outcome; D012772:Shock, Septic / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D002443:Ceftriaxone