title: Role of adiponectin on antioxidant profile: evaluation during healthy and hypertensive disorders of pregnancy.
abstract: The study of adipokines and oxidative stress has aided in understanding pre-eclampsia physiopathology. Therefore, our group aimed to evaluate the correlation between the adipokines (adiponectin and leptin) and the oxidative stress marker malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) and antioxidant activity of plasma [ferric reducing ability of plasma (FRAP)] in healthy pregnant women and patients with gestational hypertension and pre-eclampsia. We found a significant negative correlation between MDA-TBARS and adiponectin (r = -0.40, p = 0.0042), suggesting a relationship between antioxidant levels and this adipokine in healthy pregnancies which is altered in patients with gestational hypertension or pre-eclampsia.
authors.affiliation: a Department of Pharmacology , Institute of Biosciences, State University of Sao Paulo (UNESP) , Botucatu , SP , Brazil ;
authors.forename: Níbia Mariana
authors.initials: NM
authors.lastname: Eleuterio
authors.affiliation: b Department of Pharmacology, Faculty of Medicinal Sciences , State University of Campinas , Campinas , SP , Brazil ;
authors.forename: Ana C T
authors.initials: AC
authors.lastname: Palei
authors.affiliation: c Departments of Gynecology and Obstetrics ;
authors.forename: Jackeline S Rangel
authors.initials: JS
authors.lastname: Machado
authors.affiliation: d Pharmacology, Faculty of Medicine of Ribeirao Preto , University of Sao Paulo , Ribeirao Preto , SP , Brazil.
authors.forename: Jose E
authors.initials: JE
authors.lastname: Tanus-Santos
authors.affiliation: c Departments of Gynecology and Obstetrics ;
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Cavalli
authors.affiliation: a Department of Pharmacology , Institute of Biosciences, State University of Sao Paulo (UNESP) , Botucatu , SP , Brazil ;
authors.forename: Valeria C
authors.initials: VC
authors.lastname: Sandrim
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000378:metabolism; D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood* / Q000378:metabolism; D020738:Leptin / Q000097:blood / Q000378:metabolism; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D018384:Oxidative Stress; D011247:Pregnancy; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis / Q000378:metabolism; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D000975:Antioxidants; D020738:Leptin; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde
keywords: Adipokines; gestational hypertension; oxidative stress; pre-eclampsia; pregnancy