title: Serum Beta-Trace Protein as a Novel Predictor of Pregnancy-Induced Hypertension.
abstract: Beta-trace protein (BTP) has emerged as a novel biomarker of cardiovascular risk. However, the level of circulating BTP in pregnancy-induced hypertension (PIH) is still unknown. The aim of this study was to determine the concentration of serum BTP in healthy pregnant women and patients with PIH. No significant difference was found in the serum concentration of BTP in patients with a normal pregnancy. In contrast, serum BTP levels in women with PIH (n=46) were significantly higher than those in women with normal pregnancy (n=57). Receiver operating characteristic analysis revealed that using a serum BTP value of 321.3 ng/mL as a cutoff produced a sensitivity of 91.3% and a specificity of 89.5%. Taken together, these findings suggest that a higher serum BTP concentration in PIH patients compared with those with normal pregnancy and serum BTP might be a novel biomarker in the diagnosis of PIH.
authors.affiliation: Department of Obstetrics and Gynecology, QiLu Hospital of Shandong University, Ji'nan, Shandong Province, China.|Department of Obstetrics, The Central Hospital of Zibo, Zibo, Shandong Province, China.
authors.forename: Bide
authors.initials: B
authors.lastname: Duan
authors.affiliation: Department of Obstetrics, The Second Hospital of Shandong University, Ji'nan, Shandong Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics, The Central Hospital of Zibo, Zibo, Shandong Province, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Obstetrics, The People's Hospital of Rizhao, Rizhao, Shandong Province, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Obstetrics, The Central Hospital of Zibo, Zibo, Shandong Province, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Obstetrics, The Central Hospital of Zibo, Zibo, Shandong Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Geng
authors.affiliation: Department of Obstetrics and Gynecology, QiLu Hospital of Shandong University, Ji'nan, Shandong Province, China. yvyanma@126.com.
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Ma
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood* / Q000175:diagnosis; D019746:Intramolecular Oxidoreductases / Q000097:blood*; D054834:Lipocalins / Q000097:blood*; D011247:Pregnancy; D012372:ROC Curve; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D054834:Lipocalins; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase