title: Pediatric gliomatosis cerebri mimicking tubercular encephalitis.
abstract: Gliomatosis cerebri (GC) is a diffuse infiltrating glial neoplasm of astrocytic origin. GC in children is rare and difficult to diagnose, often presenting with a variety of signs and symptoms that may mimic myriad conditions. We discuss here the presentation and diagnosis of GC in a child who was initially treated on lines of tubercular encephalitis, with transient clinical relief and disappearance of enhancing component of the disease on magnetic resonance imaging. In this report, we highlight the limitations of clinical presentation and neuroimaging as well as the essential role of histological evaluation for the diagnosis of GC in children. Also is highlighted a more benign and protracted clinical course following radiotherapy in a subset of patients, with Ki index <10%, thereby stressing earliest possible diagnosis. A new prognostic classification can also be proposed for pediatric GC based on various parameters. Since these are rare cases, a combined effort is required for this.
authors.affiliation: Department of Neurosciences, SS Hospital, Agra, Uttar Pradesh, India.
authors.forename: Namit
authors.initials: N
authors.lastname: Singhal
authors.affiliation: Agarwal Neurology Clinic, Agra, Uttar Pradesh, India.
authors.forename: Vinay
authors.initials: V
authors.lastname: Agarwal
keywords: Astrocytoma; Ki index; gliomatosis cerebri; pediatric; tubercular encephalitis