title: Abnormalities of Anthropometric, Hemodynamic, and Autonomic Variables in Offspring of Hypertensive Parents.
abstract: Young adult offspring of hypertensive parents (pHTN⊕) are a good model for assessing abnormalities of anthropometric, cardiometabolic, and autonomic variables prior to clinical hypertension. The objectives of this study were to determine whether these variables and autonomic responses to oral carbohydrates were altered in offspring of pHTN⊕. Two hundred consecutive patients, including 100 pHTN⊕, were evaluated, with 29 patients, including 14 pHTN⊕, given a 70-gram carbohydrate load. The pHTN⊕ group had higher blood pressure, pulse pressure, abdominal circumference (AC), weight, body mass index, and basal metabolic rate than offspring of normotensive parents (pHTN∅). At baseline, the low-frequency (LF, sympathetic) to high-frequency (HF, parasympathetic) ratio, assessed by spectral analysis of heart rate variability, was similar in both groups. After the carbohydrate load, the LF/HF ratio was greater in offspring of pHTN⊕. pHTN⊕ individuals have abnormalities of anthropometric and hemodynamic variables at baseline and autonomic responses to oral carbohydrates before developing hypertension.
authors.affiliation: Universidade Nove de Julho-UNINOVE, Sao Paulo, Brasil. jommtta99@yahooo.com.br.|Hospital Campo Limpo, São Paulo, Brasil. jommtta99@yahooo.com.br.
authors.forename: Josiane M
authors.initials: JM
authors.lastname: Motta
authors.affiliation: Universidade Nove de Julho-UNINOVE, Sao Paulo, Brasil.
authors.forename: Tércio M
authors.initials: TM
authors.lastname: Lemos
authors.affiliation: Universidade Nove de Julho-UNINOVE, Sao Paulo, Brasil.|Heart Institute (InCor) Medical School Universidade de Sao Paulo, São Paulo, Brasil.
authors.forename: Fernanda M
authors.initials: FM
authors.lastname: Consolim-Colombo
authors.affiliation: Universidade Nove de Julho-UNINOVE, Sao Paulo, Brasil.
authors.forename: Rosa M A
authors.initials: RM
authors.lastname: Moyses
authors.affiliation: Hospital Campo Limpo, São Paulo, Brasil.
authors.forename: Marcelo A N
authors.initials: MA
authors.lastname: Gusmão
authors.affiliation: Department of Medicine, University of South Carolina School of Medicine-Greenville, Greenville, SC, USA.
authors.forename: Brent M
authors.initials: BM
authors.lastname: Egan
authors.affiliation: Universidade Nove de Julho-UNINOVE, Sao Paulo, Brasil.|Heart Institute (InCor) Medical School Universidade de Sao Paulo, São Paulo, Brasil.
authors.forename: Heno F
authors.initials: HF
authors.lastname: Lopes
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000886:Anthropometry; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D001794:Blood Pressure; D002241:Carbohydrates / Q000008:administration & dosage* / Q000494:pharmacology; D005192:Family Health; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D010290:Parents; D012307:Risk Factors; D055815:Young Adult
chemical_list: D002241:Carbohydrates