title: Startle Modification and P50 Gating in Schizophrenia Patients and Controls: Russian Population.
abstract: Prepulse modification of the acoustic startle response (ASR) and P50 gating are potential neurophysiological endophenotypes of schizophrenia and may be used in the construction of valid clinical biomarkers. Such approach requires a large amount of data obtained in the representative samples from different gender, socio-typological and ethnic groups, replicating studies using the similar protocols and meta-analyses. This is a replication study of ASR and the first study of P50 suppression in Russian patients with schizophrenia (n = 28) and healthy controls (n = 25). ASR and P50 were estimated according to standard protocols. Patients exhibited increased baseline ASR latency (d = 0.35, p = .026) and reduced prepulse inhibition (PPI) at 60 ms interval (d = 0.39, p = .003) and 120 ms interval (d = 0.37, p = .005) relative to controls. In the P50 test patients displayed greater S2 response amplitude (d = 0.24, p = .036) and deficit of P50 suppression (d = 0.43, p = .001). No correlations of PPI and P50 suppression were found in both groups. Only in controls prepulse ASR facilitation (at 2500 ms interval) positively correlated with P50 suppression (r = -.514, p = .013). In patients PPI displayed significant correlations with Difficulty in abstract thinking (N5: r = -.49, p = .005) and Hallucination (P3: r = .40, p = .036) PANSS scales. Logistic regression showed that the combination of PPI and P50 suppression could serve as a diagnostic predictor. Obtained results demonstrated that both PPI and P50 could be regarded as potential schizophrenia biomarkers in Russian population.
authors.affiliation: Serbsky National Research Centre for Social and Forensic Psychiatry (Russia).
authors.forename: Zinaida I
authors.initials: ZI
authors.lastname: Storozheva
authors.affiliation: Serbsky National Research Centre for Social and Forensic Psychiatry (Russia).
authors.forename: Anna V
authors.initials: AV
authors.lastname: Kirenskaya
authors.affiliation: Serbsky National Research Centre for Social and Forensic Psychiatry (Russia).
authors.forename: Vladimir Y
authors.initials: VY
authors.lastname: Novototsky-Vlasov
authors.affiliation: Serbsky National Research Centre for Social and Forensic Psychiatry (Russia).
authors.forename: Klavdia Y
authors.initials: KY
authors.lastname: Telesheva
authors.affiliation: Johns Hopkins University School of Medicine (USA).
authors.forename: Mikhail
authors.initials: M
authors.lastname: Pletnikov
mesh_terms: D000328:Adult; D015415:Biomarkers; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D065808:Prepulse Inhibition / Q000502:physiology*; D013216:Reflex, Startle / Q000502:physiology*; D012426:Russia; D012559:Schizophrenia / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: P50 gating; acoustic startle reaction; schizophrenia