title: Placental levels of total oxidative and anti-oxidative status, ADAMTS-12 and decorin in early- and late-onset severe preeclampsia.
abstract: OBJECTIVE
  Preeclampsia (PE), can be classified according to the timing of disease onset: early-onset PE occurs before the 34th gestational week and late-onset PE occurs in the 34th gestational week or later. The aim of this study was to determine whether total antioxidant status (TAS), and total oxidant status (TOS), ADAMTS-12 and decorin levels differ among early-onset severe PE (EOS-PE), late-onset severe PE (LOS-PE) and uncomplicated pregnancies.
  
  
  METHODS
  In this case-control study, placental samples obtained from 25 pregnant patients with EOS-PE, 26 pregnant patients with LOS-PE and 28 healthy patients with uncomplicated pregnancies (control group).
  
  
  RESULTS
  Placenta levels of decorin and TOS were significantly higher and TAS was significantly lower in the EOS-PE and LOS-PE groups than in the control group. These alterations were more prominent in patients with EOS-PE than in patients with LOS-PE. There were no significant differences in the ADAMTS-12 levels of the groups.
  
  
  CONCLUSIONS
  The distinctly higher rate of negative perinatal outcomes in both EOS-PE and LOS-PE patients is well evidenced. However, the main questions that need to be answered are whether the only difference between these two diseases is the time of their onset and whether the only difference between them with respect to fetal morbidity and mortality is prematurity.
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey and.
authors.forename: Korkut
authors.initials: K
authors.lastname: Daglar
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey and.
authors.forename: Ayse
authors.initials: A
authors.lastname: Kirbas
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey and.
authors.forename: Hakan
authors.initials: H
authors.lastname: Timur
authors.affiliation: b Department of Obstetrics and Gynecology , Konya Education and Research Hospital , Konya , Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ozturk Inal
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey and.
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
mesh_terms: D051722:ADAM Proteins / Q000032:analysis* / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D058575:Decorin / Q000032:analysis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D000067562:Late Onset Disorders; D010084:Oxidation-Reduction; D010920:Placenta / Q000737:chemistry* / Q000378:metabolism; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D058575:Decorin; D051722:ADAM Proteins
keywords: Fetal growth restriction; matrix metalloproteinase; oxidative stress; placenta; trophoblast