title: SOX7 is associated with the suppression of human glioma by HMG-box dependent regulation of Wnt/β-catenin signaling.
abstract: SOX7 has been recently recognized as a tumor suppressor belonging to the SOX (SRY-related HMG-box) family of a transcription factor. However, its role in human gliomas is unknown. Our study showed that SOX7 expression was significantly downregulated in human gliomas. Statistical analysis showed that SOX7 suppression was associated with higher histological grades of tumors in glioma tissues. SOX7 could suppress tumor properties both in vivo and in vitro, and depletion of the HMG domain abolishes its tumor suppressive roles. In vitro assays demonstrated that SOX7 could downregulate Wnt/β-catenin transcription and decrease the expression of Cyclin D1 and c-Myc, while the mutant SOX7 lost these functions. These results suggested that the HMG-box is a key domain of SOX7 for negatively regulating the Wnt/β-catenin signaling pathway when functioning as a tumor suppressor in a glioma.
authors.affiliation: Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Tianshu
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Clinical Laboratory, Beijing Shijiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Su
authors.affiliation: Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Baijing
authors.initials: B
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Ce
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: jiangchuanlusox@163.com.
authors.forename: Chuanlu
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China. Electronic address: liuxiaoqiansox@163.com.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Liu
mesh_terms: D000328:Adult; D000818:Animals; D001665:Binding Sites; D001932:Brain Neoplasms / Q000378:metabolism*; D063646:Carcinogenesis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D008297:Male; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D017434:Protein Structure, Tertiary; D055760:SOXF Transcription Factors / Q000502:physiology*; D060449:Wnt Signaling Pathway
chemical_list: C484456:SOX7 protein, human; D055760:SOXF Transcription Factors
keywords: Glioma; SOX7; Tumor suppressor; Wnt/β-catenin