title: Severe Small-Vessel Vasculitis Temporally Associated With Administration of Ustekinumab.
abstract: Vasculitis may be caused by infection, medications, systemic diseases, malignancy, or occur as an idiopathic condition. In cases of drug-induced vasculitis, it is essential to identify and discontinue the culprit medication. As novel agents are approved through clinical trials, some rare events, including vasculitis, may not become apparent until wider use, and rigorous post-marketing surveillance for new medications is important. Physicians should consider drug-induced vasculitis on the differential for all new vasculitis diagnoses, and if the potential triggering medication is a novel medication, it is essential to rigorously investigate the potential for emerging cases of medication-associated vasculitis in all available scientific literature.
authors.forename: Kelly M
authors.initials: KM
authors.lastname: MacArthur
authors.forename: Peter A
authors.initials: PA
authors.lastname: Merkel
authors.forename: Abby S
authors.initials: AS
authors.lastname: Van Voorhees
authors.forename: Jennifer
authors.initials: J
authors.lastname: Nguyen
authors.forename: Misha
authors.initials: M
authors.lastname: Rosenbach
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000175:diagnosis; D001706:Biopsy; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007279:Injections, Subcutaneous; D007866:Leg / Q000473:pathology; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy*; D012867:Skin / Q000382:microbiology / Q000473:pathology; D013211:Staphylococcus aureus; D000069549:Ustekinumab / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology
chemical_list: D003879:Dermatologic Agents; D005938:Glucocorticoids; D000069549:Ustekinumab; D011241:Prednisone