title: Nitride coating enhances endothelialization on biomedical NiTi shape memory alloy.
abstract: Surface nitriding was demonstrated to be an effective process for improving the biocompatibility of implantable devices. In this study, we investigated the benefits of nitriding the NiTi shape memory alloy for vascular stent applications. Results from cell experiments indicated that, compared to untreated NiTi, a superficial gas nitriding treatment enhanced the adhesion of human umbilical vein endothelial cells (HUVECs), cell spreading and proliferation. This investigation provides data to demonstrate the possibility of improving the rate of endothelialization on NiTi by means of nitride coating.
authors.affiliation: University of Bucharest, Department of Biochemistry and Molecular Biology, 91-95 Spl. Independentei, 050095 Bucharest, Romania.
authors.forename: Raluca
authors.initials: R
authors.lastname: Ion
authors.affiliation: National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor, P.O. Box MG-36, 077125 Magurele-Bucharest, Romania.
authors.forename: Catalin
authors.initials: C
authors.lastname: Luculescu
authors.affiliation: University of Bucharest, Department of Biochemistry and Molecular Biology, 91-95 Spl. Independentei, 050095 Bucharest, Romania. Electronic address: anisoara.cimpean@bio.unibuc.ro.
authors.forename: Anisoara
authors.initials: A
authors.lastname: Cimpean
authors.affiliation: AMF Company, Route de Quincy, 18120 Lury-sur-Arnon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Marx
authors.affiliation: INSA Rennes, UMR CNRS 6226 ISCR, 20 Avenue des Buttes de Coësmes, 35708 Rennes Cedex 7, France.
authors.forename: Doina-Margareta
authors.initials: DM
authors.lastname: Gordin
authors.affiliation: INSA Rennes, UMR CNRS 6226 ISCR, 20 Avenue des Buttes de Coësmes, 35708 Rennes Cedex 7, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Gloriant
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D009532:Nickel / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D020099:Coated Materials, Biocompatible; C040654:titanium nickelide; D009532:Nickel; D014025:Titanium
keywords: Endothelialization; HUVEC; NiTi alloy; Surface nitriding