title: Expectant management of severe preterm preeclampsia: a comparison of maternal and fetal indications for delivery.
abstract: OBJECTIVE
  To examine the delivery indication (maternal or fetal) for patients with preterm preeclampsia and assess whether disease characteristics at presentation are predictive of delivery indication.
  
  
  METHODS
  We conducted a retrospective cohort study at a tertiary hospital in Melbourne, Australia (Mercy Hospital for Women). We assessed indication for delivery for participants presenting with preeclampsia from 23(+0) to 32(+6) weeks gestation. We compared baseline disease characteristics, disease features at delivery and postnatal outcomes between those delivered for maternal or fetal indications, or for both maternal and fetal indications.
  
  
  RESULTS
  Two hundred sixty six participants presented with preterm preeclampsia and 108 were eligible for inclusion in our study. More participants were delivered for maternal indications at 65.7% compared to those requiring delivery on fetal grounds at 19.4% or for both indications at 14.8% (p < 0.0001). Maternal disease characteristics at presentation were similar between groups; however, there was a higher proportion of growth restriction and abnormal Dopplers among those delivered on fetal grounds. Participants delivered on maternal grounds gained less gestation, had higher blood pressure and higher incidence of abnormal liver function tests than those delivering for fetal indications at delivery.
  
  
  CONCLUSIONS
  Participants with preterm preeclampsia were predominantly delivered due to maternal disease progression compared to fetal compromise.
authors.affiliation: a Department of Obstetrics and Gynaecology , Mercy Hospital for Women , Heidelberg , Victoria , Australia and.
authors.forename: Samantha S
authors.initials: SS
authors.lastname: Mooney
authors.affiliation: a Department of Obstetrics and Gynaecology , Mercy Hospital for Women , Heidelberg , Victoria , Australia and.
authors.forename: Rilka M
authors.initials: RM
authors.lastname: Lee
authors.affiliation: b Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women , Heidelberg , Victoria , Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Tong
authors.affiliation: b Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women , Heidelberg , Victoria , Australia.
authors.forename: Fiona C
authors.initials: FC
authors.lastname: Brownfoot
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D036861:Delivery, Obstetric; D018450:Disease Progression; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D054238:Perinatal Mortality; D011225:Pre-Eclampsia / Q000175:diagnosis; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors; D057832:Watchful Waiting
keywords: Delivery indication; fetal morbidity; maternal morbidity; preterm preeclampsia; therapeutics