title: Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation.
abstract: Photoactivatable CO releasing protein crystals were developed by immobilization of Mn carbonyl complexes in polyhedral crystals, which are spontaneously formed in insect cells. The photoactivatable CO release from the engineered protein crystals activates nuclear factor kappa B (NF-κB) upon stimulation by visible light irradiation with suppression of cytotoxicity of the Mn complex.
authors.affiliation: Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. kitagawa@icems.kyoto-u.ac.jp.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Tabe
authors.affiliation: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Midori-ku, Yokohama 224-8501, Japan. tueno@bio.titech.ac.jp.
authors.forename: Takuya
authors.initials: T
authors.lastname: Shimoi
authors.affiliation: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC3800, Australia.
authors.forename: Marion
authors.initials: M
authors.lastname: Boudes
authors.affiliation: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Midori-ku, Yokohama 224-8501, Japan. tueno@bio.titech.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Abe
authors.affiliation: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC3800, Australia.
authors.forename: Fasséli
authors.initials: F
authors.lastname: Coulibaly
authors.affiliation: Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. kitagawa@icems.kyoto-u.ac.jp.
authors.forename: Susumu
authors.initials: S
authors.lastname: Kitagawa
authors.affiliation: Insect Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Mori
authors.affiliation: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Midori-ku, Yokohama 224-8501, Japan. tueno@bio.titech.ac.jp.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ueno
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000737:chemistry*; D016328:NF-kappa B / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry*; D018411:Spodoptera
chemical_list: D016328:NF-kappa B; D011506:Proteins; D002248:Carbon Monoxide