title: The clinical significance of atypical antipsychotics.
abstract: A concise review is given of the importance of the atypical antipsychotic drugs clozapine, sulpiride, remoxipride and raclopride. Both the concept of atypicality and the pharmacological profile of these compounds is discussed. The newly developed atypical antipsychotic remoxipride has been studied in several double blind studies. In virtually all of these studies a reduced propensity for the induction of extrapyramidal symptoms was found. These findings implicate that atypical antipsychotics may also not induce tardive dyskinesia. In addition to the treatment of acute schizophrenia, these compounds might be of use in the treatment of treatment resistent schizophrenia (clozapine), tardive dyskinesia and psychosis during the course of Parkinson's disease.
authors.affiliation: psychiater en klinisch farmacoloog verbonden aan de Afdeling Biologische,Psychiatrie van het AZU.
authors.forename: J A
authors.initials: JA
authors.lastname: Boer
authors.affiliation: psychiater en klinisch farmacoloog verbonden aan de Afdeling Biologische,Psychiatrie van het AZU.
authors.forename: H G
authors.initials: HG
authors.lastname: Westenberg
authors.affiliation: psychiater verbonden aan de afdeling psychiatrie van het Academisch Ziekenhuis Groningen,alsmede Psychiatrisch Ziekenhuis Licht en Kracht te Assen.
authors.forename: J W
authors.initials: JW
authors.lastname: Louwerens
authors.affiliation: psychiater verbonden aan de afdeling psychiatrie van het Academisch Ziekenhuis Groningen,alsmede Psychiatrisch Ziekenhuis Licht en Kracht te Assen.
authors.forename: C J
authors.initials: CJ
authors.lastname: Slooff