title: The frequency of hematuria in acne vulgaris patients during isotretinoin treatment.
abstract: BACKGROUND
  Systemic isotretinoin (13-cis-retinoic acid) is effective in the treatment of acne vulgaris. The most common side effects are mucocutaneous ones. Hematuria seen secondary to isotretinoin treatment is thought to be due to mucosal dryness in the urinary system. This study aims to determine the frequency of hematuria in acne vulgaris patients during isotretinoin treatment.
  
  
  METHODS
  Eighty-eight subjects aged 16-32 years were included in the study group and 52 subjects were in the control group. The subjects were treated for 6 months and were monitored monthly by complete urine analyzes. They were also examined each month in terms of cheilitis, xerosis, epistaxis, rectal bleeding, fatigue, myalgia, weight loss, dry eye, conjunctivitis, headache, dysuria and pollakiuria.
  
  
  RESULTS
  In the study group, 15 subjects (17%) had hematuria at least once during the study, and in the control group, four subjects (7.7%) had hematuria. The difference was not statistically significant (p = 0.118). Among the subjects who had hematuria, 11 of them (73.3%) were female and four of them (33.3%) were male in the study group while all the subjects with hematuria in the control group were female. Hematuria and gender did not show a statistically significant correlation.
  
  
  CONCLUSIONS
  Hematuria was observed in 17% of the study group; this frequency rate was not different from that of the normal population. In subjects having isotretinoin treatment, if all the other reasons or disorders are excluded, one must keep in mind that hematuria may be due to isotretinoin use.
authors.affiliation: a Department of Dermatology , Ankara Numune Education and Research Hospital , Ankara , Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Yesilkaya
authors.affiliation: b Department of Dermatology and Venereology , Kafkas University , Kars , Turkey , and.
authors.forename: Nuran
authors.initials: N
authors.lastname: Alli
authors.affiliation: a Department of Dermatology , Ankara Numune Education and Research Hospital , Ankara , Turkey.
authors.forename: R Ferda
authors.initials: RF
authors.lastname: Artuz
authors.affiliation: a Department of Dermatology , Ankara Numune Education and Research Hospital , Ankara , Turkey.
authors.forename: Ezgi
authors.initials: E
authors.lastname: Ulu
authors.affiliation: c Department of Dermatology , Faculty of Medicine, Erciyes University , Kayseri , Turkey.
authors.forename: Demet
authors.initials: D
authors.lastname: Kartal
authors.affiliation: c Department of Dermatology , Faculty of Medicine, Erciyes University , Kayseri , Turkey.
authors.forename: S Levent
authors.initials: SL
authors.lastname: Cinar
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000652:urine; D000293:Adolescent; D000328:Adult; D003879:Dermatologic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006417:Hematuria / Q000139:chemically induced* / Q000652:urine; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin
keywords: Acne vulgaris; hematuria; isotretinoin