title: Association Between the Transforming Growth Factor Beta 1 Gene Polymorphisms and Turkish Patients with Nonsyndromic Cleft Lip With/Without Cleft Palate.
abstract: OBJECTIVE
  To examine transforming growth factor beta 1 (TGFβ1) gene polymorphisms in Turkish patients with nonsyndromic cleft lip with/without cleft palate (nsCL/P).
  
  
  METHODS
  A total of 205 Turkish subjects were included; 80 nsCL/P patients and 125 unrelated control individuals. Analysis of gene polymorphisms was carried out by polymerase chain reaction and DNA sequencing.
  
  
  RESULTS
  We found the substitution of a proline by a leucine at codon 10 (Pro10Leu) and the substitution of an arginine by a proline at codon 25 (Arg25Pro) in exon 1 of the TGFβ1 gene in nsCL/P patients.
  
  
  CONCLUSIONS
  This is the first report investigating prevalence of TGFβ1 polymorphisms in Turkish patients with nsCL/P.
authors.affiliation: Department of Biology, Faculty of Science, Gazi University , Ankara, Turkey .
authors.forename: Deniz Aslar
authors.initials: DA
authors.lastname: Oner
authors.affiliation: Department of Biology, Faculty of Science, Gazi University , Ankara, Turkey .
authors.forename: Hakki
authors.initials: H
authors.lastname: Tastan
mesh_terms: D019943:Amino Acid Substitution; D001120:Arginine / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002971:Cleft Lip / Q000150:complications / Q000235:genetics*; D002972:Cleft Palate / Q000150:complications / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007930:Leucine / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011392:Proline / Q000235:genetics; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D014421:Turkey
chemical_list: C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1; D001120:Arginine; D011392:Proline; D007930:Leucine