title: RIT2 Polymorphisms: Is There a Differential Association?
abstract: Neurological disorders include a wide variety of mostly multifactorial diseases related to the development, survival, and function of the neuron cells. Single-nucleotide polymorphisms (SNPs) have been extensively studied in neurological disorders, and in a number of instances have been reproducibly linked to disease as risk factors. The RIT2 gene has been recently shown to be associated with a number of neurological disorders, such as Parkinson's disease (PD) and autism. In the study reported here, we investigated the association of the rs12456492 and rs16976358 SNPs of the RIT2 gene with PD, essential tremor (ET), autism, schizophrenia (SCZ), and bipolar disorder (BPD; total of 2290 patients), and 1000 controls, by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Significant association was observed between rs12456492 and two disorders, PD and ET, whereas rs16976358 was found to be associated with autism, SCZ, and BPD. Our findings are indicative of differential association between the RIT2 SNPs and different neurological disorders.
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Emamalizadeh
authors.affiliation: Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Jamshidi
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Movafagh
authors.affiliation: Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Ohadi
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Tabriz University of medical Sciences, Tabriz, Iran.|Neurosciences Research Center, Tabriz University of medical Sciences, Tabriz, Iran.
authors.forename: Mahmoud Shekari
authors.initials: MS
authors.lastname: Khaniani
authors.affiliation: Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Somayyeh
authors.initials: S
authors.lastname: Kazeminasab
authors.affiliation: Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Akbar
authors.initials: A
authors.lastname: Biglarian
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Taghavi
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Motallebi
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Atena
authors.initials: A
authors.lastname: Fazeli
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Ahmadifard
authors.affiliation: Movement Disorders Clinic, Hazrat Rassol Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Gholam-Ali
authors.initials: GA
authors.lastname: Shahidi
authors.affiliation: Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Petramfar
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Shahmohammadibeni
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Dadkhah
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Ehteram
authors.initials: E
authors.lastname: Khademi
authors.affiliation: Department of Neurology, School of Medicine, Imam Khomeini Hospital and Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Tafakhori
authors.affiliation: Sabzevar University of Medical Sciences, Sabzevar, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Khaligh
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Tannaz
authors.initials: T
authors.lastname: Safaralizadeh
authors.affiliation: Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Kowsari
authors.affiliation: Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Mirabzadeh
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Amir Ehtesham Shafiei
authors.initials: AES
authors.lastname: Zarneh
authors.affiliation: Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Khorrami
authors.affiliation: Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Parasto
authors.initials: P
authors.lastname: Shokraeian
authors.affiliation: Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran.
authors.forename: Mohammad Javad Soltani
authors.initials: MJS
authors.lastname: Banavandi
authors.affiliation: Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Behnam Safarpour
authors.initials: BS
authors.lastname: Lima
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Monavvar
authors.initials: M
authors.lastname: Andarva
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Alehabib
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Minoo
authors.initials: M
authors.lastname: Atakhorrami
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. darvish_mg@yahoo.com.
authors.forename: Hossein
authors.initials: H
authors.lastname: Darvish
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D001321:Autistic Disorder / Q000235:genetics; D001714:Bipolar Disorder / Q000235:genetics; D020329:Essential Tremor / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D020559:Monomeric GTP-Binding Proteins; C583559:RiT2 protein, human
keywords: Autism; Bipolar disorder; Essential tremor; Neurological disorders; Parkinson’s disease; Polymorphism; RIT2; Schizophrenia