title: Optogenetic Modulation of Locomotor Activity on Free-Behaving Rats.
abstract: The technology of optogenetics provides a new method to modulate neural activity with spatial specificity and millisecond-temporal scale. This nonelectrical modulation method also gives chance for simultaneous electrophysiological recording during stimulations. Here, we describe our locomotor activity modulation on free-behaving rats using optogenetic techniques. The target sites of the rat brain were dorsal periaqueductal gray (dPAG) and ventral tegmental area (VTA) for the modulation of defensive and reward behaviors, respectively.
authors.affiliation: Qiushi Academy for Advanced Studies (QAAS), Zhejiang University, Hangzhou, 310027, China.|Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Education Ministry, Zhejiang University, Hangzhou, 310027, China.|Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Hangzhou, 310027, China.
authors.forename: Kedi
authors.initials: K
authors.lastname: Xu
authors.affiliation: Qiushi Academy for Advanced Studies (QAAS), Zhejiang University, Hangzhou, 310027, China.|Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Education Ministry, Zhejiang University, Hangzhou, 310027, China.|Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Hangzhou, 310027, China.
authors.forename: Jiacheng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Qiushi Academy for Advanced Studies (QAAS), Zhejiang University, Hangzhou, 310027, China.|Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Education Ministry, Zhejiang University, Hangzhou, 310027, China.|Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Hangzhou, 310027, China.
authors.forename: Songchao
authors.initials: S
authors.lastname: Guo
authors.affiliation: Qiushi Academy for Advanced Studies (QAAS), Zhejiang University, Hangzhou, 310027, China. qaas@zju.edu.cn.|Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Education Ministry, Zhejiang University, Hangzhou, 310027, China. qaas@zju.edu.cn.|Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Hangzhou, 310027, China. qaas@zju.edu.cn.
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D004567:Electrodes, Implanted; D055724:Electrophysiological Phenomena / Q000528:radiation effects; D008124:Locomotion / Q000528:radiation effects; D009043:Motor Activity / Q000528:radiation effects*; D062308:Optogenetics / Q000379:methods*; D010487:Periaqueductal Gray / Q000502:physiology* / Q000528:radiation effects; D010775:Photic Stimulation / Q000379:methods*; D051381:Rats; D017557:Ventral Tegmental Area / Q000502:physiology* / Q000528:radiation effects; D014780:Viruses / Q000235:genetics
keywords: Locomotor activity modulation; Optical-electrode array; Optogenetics; VTA; Virus injection; dPAG