title: Control Status of Atherosclerotic Cardiovascular Risk Factors Among Japanese High-Risk Subjects:Analyses of a Japanese Health Check Database from 2008 to 2011.
abstract: OBJECTIVE
  Several guidelines propose target levels (TLs) of atherosclerotic risk factors (ARFs) to reduce atherosclerotic cardiovascular diseases; however, few data are available regarding the attainment statuses of TLs in Japan. In this study, utilizing the data obtained from the annual "Specific Health Check and Guidance in Japan" conducted from 2008 to 2011 (approximately 280,000 subjects each year), we determined TL attainments of ARFs in cardiovascular high-risk subjects.
  
  
  METHODS
  Those who had suffered from cerebrovascular disease (pCVD) or coronary heart disease (pCHD) or were receiving diabetes mellitus treatment (DM) were selected, and the rates of subjects that attained TLs of blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and glycated hemoglobin (HbA1c) were analyzed.
  
  
  RESULTS
  Approximately 70% of pCVD or pCHD and 35% of subjects with DM attained TLs of BP. With regard to HbA1c, ＞90% of pCVD or pCHD and approximately 50% of subjects with DM attained TLs. With regard to LDL-C, ＜25% of pCHD females and approximately 35% of pCHD males and 50%-55% of subjects with pCVD or DM attained TLs. The TL-attainment rates of HDL-C and TGs were approximately 90% and 75%, respectively, for the three diseases. Analyses of time course changes in their attainment statuses revealed that the attainment rates of BP and LDL-C significantly improved in all the diseases.
  
  
  CONCLUSIONS
  TL-attainment rates of BP and LDL-C were not as high as those for HDL-C, TGs, and HbA1c; however, they both showed highly significant improvements during the study period.
authors.affiliation: Department of Metabolism, Diabetes and Nephrology, Aizu Medical Center, Fukushima Medical University.
authors.forename: Koji
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Tsukamoto
authors.forename: Motoei
authors.initials: M
authors.lastname: Kunimi
authors.forename: Koichi
authors.initials: K
authors.lastname: Asahi
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Iseki
authors.forename: Toshiki
authors.initials: T
authors.lastname: Moriyama
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Yamagata
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Tsuruya
authors.forename: Shouichi
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Ichiei
authors.initials: I
authors.lastname: Narita
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Konta
authors.forename: Masahide
authors.initials: M
authors.lastname: Kondo
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kimura
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D001794:Blood Pressure; D002561:Cerebrovascular Disorders / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D016208:Databases, Factual; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014280:Triglycerides