title: NMR-based metabolomics of prostate cancer: a protagonist in clinical diagnostics.
abstract: Advances in the application of NMR spectroscopy-based metabolomic profiling of prostate cancer comprises a potential tactic for understanding the impaired biochemical pathways arising due to a disease evolvement and progression. This technique involves qualitative and quantitative estimation of plethora of small molecular weight metabolites of body fluids or tissues using state-of-the-art chemometric methods delivering an important platform for translational research from basic to clinical, to reveal the pathophysiological snapshot in a single step. This review summarizes the present arrays and recent advancements in NMR-based metabolomics and a glimpse of currently used medical imaging tactics, with their role in clinical diagnosis of prostate cancer.
authors.affiliation: a Centre of Biomedical Research, SGPGIMS Campus , Lucknow , UP , India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Kumar
authors.affiliation: a Centre of Biomedical Research, SGPGIMS Campus , Lucknow , UP , India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Gupta
authors.affiliation: b Department of Radiology , University of Pennsylvania , Philadelphia , PA , USA.
authors.forename: Kavindra
authors.initials: K
authors.lastname: Nath
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D055442:Metabolome; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
keywords: MRSI; Metabolomics; NMR spectroscopy; PET; clinical intervention; prostate cancer