title: An observational study assessing peripheral neuropathy related to multiple myeloma.
abstract: We aimed at assessing the prevalence of peripheral neuropathy in newly diagnosed, treatment-naïve patients with multiple myeloma. We enrolled 153 patients with multiple myeloma at initial diagnosis. All patients underwent neurological examination and nerve conduction study. Patients with suspected pure small fiber neuropathy underwent skin biopsy. Of the 153 patients included in this study, 7.2 % had a multiple myeloma-related neuropathy. All patients suffered from a distal symmetric sensory peripheral neuropathy, associated with age (P = 0.04). Our study on prevalence rate of multiple myeloma-related peripheral neuropathy might provide a basis for improving the clinical management of this condition.
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University, Rome, Italy. caterinamaria.leone@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Leone
authors.affiliation: Department of Cellular Biotechnology and Haematology, Sapienza University, Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Federico
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: La Cesa
authors.affiliation: Department of Cellular Biotechnology and Haematology, Sapienza University, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Russo
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Di Stefano
authors.affiliation: Department of Cellular Biotechnology and Haematology, Sapienza University, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Finsinger
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Labriola
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cruccu
authors.affiliation: Department of Cellular Biotechnology and Haematology, Sapienza University, Rome, Italy.
authors.forename: M T
authors.initials: MT
authors.lastname: Petrucci
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Truini
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy
keywords: Multiple myeloma; Polyneuropathy; Skin biopsy