title: Insights into centromeric transcription in mitosis.
abstract: The major role of RNA polymerase II (RNAP II) is to generate mRNAs. I recently uncovered a novel function of RNAP II in chromosome segregation in mitosis, installing the cohesin protector, Shugoshin, at centromeres. Here I will discuss the current understanding of RNAP II-dependent centromeric transcription in mitosis.
authors.affiliation: a Department of Biochemistry and Molecular Biology , Tulane University; School of Medicine , New Orleans , LA , USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
mesh_terms: D001324:Autoantigens / Q000235:genetics / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D002503:Centromere / Q000235:genetics*; D000076247:Centromere Protein A; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D020090:Chromosome Segregation; D006801:Humans; D008938:Mitosis; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D001324:Autoantigens; D018797:Cell Cycle Proteins; D000076247:Centromere Protein A; D002868:Chromosomal Proteins, Non-Histone; C496644:SGO1 protein, human; C584277:BUB1 protein, human; D017346:Protein Serine-Threonine Kinases; D012319:RNA Polymerase II
keywords: Bub1; RNA polymerase II; Sgo1; centromere; centromeric cohesion; kinetochore; mitosis; transcription