title: Association of single nucleotide polymorphisms in UBR2 gene with idiopathic aspermia or oligospermia in Sichuan, China.
abstract: The associations between three single nucleotide polymorphisms (SNPs; rs3749897, rs16895863 and rs373341) of UBR2 gene and idiopathic aspermia or oligospermia were investigated in this study by a case-control experiment with 149 fertile and 316 infertile men, including 244 patients with idiopathic aspermia and 72 patients with severe oligospermia. The time-of-flight mass spectrometry (Sequenom MassARRAY®system) was used in this study. A significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) was observed in this research (odds ratio [OR]: 2.764; 95% CI: 95% confidence interval [CI]: 1.171-6.525; P = 0.017), which could indicate that the combined AT-TC-CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China.
authors.affiliation: Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, School of Life Science, Institute of Medical Genetics, Sichuan University, Chengdu, China.|Bio-resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Chengdu, China.|Biotechnology Academy of Nanchuan, Chongqing, China.
authors.forename: T-J
authors.initials: TJ
authors.lastname: Ma
authors.affiliation: Yongchuan Hospital of Chongqing Medical University, Yongchuan, Chongqing, China.
authors.forename: X-J
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, School of Life Science, Institute of Medical Genetics, Sichuan University, Chengdu, China.|Bio-resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Chengdu, China.|Biotechnology Academy of Nanchuan, Chongqing, China.
authors.forename: X-P
authors.initials: XP
authors.lastname: Ding
authors.affiliation: Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, School of Life Science, Institute of Medical Genetics, Sichuan University, Chengdu, China.|Bio-resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Chengdu, China.|Biotechnology Academy of Nanchuan, Chongqing, China.
authors.forename: H-H
authors.initials: HH
authors.lastname: Chen
authors.affiliation: Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, School of Life Science, Institute of Medical Genetics, Sichuan University, Chengdu, China.|Bio-resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Chengdu, China.|Biotechnology Academy of Nanchuan, Chongqing, China.
authors.forename: Y-W
authors.initials: YW
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, School of Life Science, Institute of Medical Genetics, Sichuan University, Chengdu, China.|Bio-resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Chengdu, China.|Biotechnology Academy of Nanchuan, Chongqing, China.
authors.forename: M
authors.initials: M
authors.lastname: Ding
mesh_terms: D000328:Adult; D000483:Alleles; D053714:Aspermia / Q000235:genetics*; D002681:China; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D055815:Young Adult
chemical_list: C499858:UBR2 protein, human; D044767:Ubiquitin-Protein Ligases
keywords: Idiopathic infertility; UBR2 gene; polymorphisms; time-of-flight mass spectrometry