title: Enantioselective Friedel-Crafts Alkylation Reactions of 3-Substituted Indoles with Electron-Deficient Alkenes.
abstract: Highly enantioselective Friedel-Crafts C2-alkylation reactions of 3-substituted indoles with α,β-unsaturated esters and nitroalkenes were developed using chiral Lewis acids as catalysts, which afforded chiral indole derivatives bearing C2-benzylic stereogenic centers in good to excellent yields (up to 99%) and enantioselectivities (up to 96% ee).
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Jian-Quan
authors.initials: JQ
authors.lastname: Weng
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Ren-Jie
authors.initials: RJ
authors.lastname: Fan
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Qiao-Man
authors.initials: QM
authors.lastname: Deng
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Ren-Rong
authors.initials: RR
authors.lastname: Liu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Gao
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Yi-Xia
authors.initials: YX
authors.lastname: Jia