title: Pathogenesis of Castleman's Disease.
abstract: Castleman's disease (CD) is a rare lymphoproliferative disorder that comprises at least two distinct clinical subtypes (unicentric and multicentric). Three pathologic variants (hyaline vascular variant, plasma cell variant, and mixed variant) have been recognized. In addition to interleukin-6 and human herpes virus 8, some other cytokines and viruses may also be involved in the pathogenesis of CD. This review summarizes the recent advances in the underlying pathogenesis of CD, with an attempt to provide evidence for new treatment options that may change the current treatment strategies and improve patients' outcomes.
authors.affiliation: Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
mesh_terms: D005871:Castleman Disease; D019288:Herpesvirus 8, Human; D006801:Humans; D015850:Interleukin-6
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6