title: Brief Report: HIV-1 Tropism During Primary Infections in France: 1996-2014.
abstract: HIV-1 was mainly CCR5 tropic in recent seroconverters. We analyzed the coreceptor use in 239 primary HIV-1 infections (PHIs) between 1996 and 2014 using a validated recombinant virus phenotypic entry assay. CXCR4-using viruses were detected in 8.3%, 3.8%, and 6.1% of PHIs from 1996 to 2004, 2005 to 2009, and 2010 to 2014, respectively. The presence of CXCR4-using viruses was associated with the virological failure of antiretroviral treatment initiated during PHI (odds ratio, 7.9; 95% confidence interval, 1.1 to 56.5). The phenotypic tropism assay data show that the prevalence of X4 tropic transmitted viruses was stable in this French cohort of PHIs between 1996 and 2014.
authors.affiliation: *INSERM, U1043, Toulouse, France; †Université Toulouse III Paul-Sabatier, Faculté de Médecine Toulouse-Purpan, Toulouse, France; ‡CHU de Toulouse, Hôpital Purpan, Laboratoire de Virologie, Toulouse, France; and §CHU de Toulouse, Hôpital Purpan, Service des Maladies Infectieuses et Tropicales, Toulouse, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Raymond
authors.forename: Florence
authors.initials: F
authors.lastname: Nicot
authors.forename: Karine
authors.initials: K
authors.lastname: Sauné
authors.forename: Michelle
authors.initials: M
authors.lastname: Cazabat
authors.forename: Christophe
authors.initials: C
authors.lastname: Pasquier
authors.forename: Patrice
authors.initials: P
authors.lastname: Massip
authors.forename: Bruno
authors.initials: B
authors.lastname: Marchou
authors.forename: Pierre
authors.initials: P
authors.lastname: Delobel
authors.forename: Jacques
authors.initials: J
authors.lastname: Izopet
mesh_terms: D000328:Adult; D005260:Female; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008297:Male; D015995:Prevalence; D019718:Receptors, CXCR4 / Q000378:metabolism*; D015728:Receptors, HIV / Q000378:metabolism*; D056189:Viral Tropism
chemical_list: C527276:CXCR4 protein, human; D019718:Receptors, CXCR4; D015728:Receptors, HIV