title: Current treatment approaches and trials in central sleep apnea.
abstract: Central sleep apnea (CSA) is one of the most common comorbidities in patients with heart failure with reduced ejection fraction and is associated with negative consequences. Despite several recent advances, there are currently no widely accepted therapies for CSA. In this review we will discuss available therapies for CSA and review the published trials addressing treatment of CSA in HFrEF patients.
authors.affiliation: Sleep Heart Program, The Ohio State University, Columbus, OH, United States. Electronic address: rami.khayat@osumc.edu.
authors.forename: Rami N
authors.initials: RN
authors.lastname: Khayat
authors.affiliation: Sleep Heart Program, The Ohio State University, Columbus, OH, United States; Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, United States.
authors.forename: William T
authors.initials: WT
authors.lastname: Abraham
mesh_terms: D002245:Carbon Dioxide / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D019468:Disease Management; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D010102:Oxygen Inhalation Therapy / Q000379:methods; D017286:Polysomnography; D011175:Positive-Pressure Respiration / Q000379:methods; D020182:Sleep Apnea, Central / Q000628:therapy*; D004561:Transcutaneous Electric Nerve Stimulation / Q000379:methods; D016896:Treatment Outcome
chemical_list: D006993:Hypnotics and Sedatives; D002245:Carbon Dioxide
keywords: Central sleep apnea; Continuous positive airway pressure; Heart failure; Phrenic nerve stimulation; Sleep apnea