title: Common Polymorphisms in IL-27 Genes May Contribute to Risk of Various Human Diseases in Asian Populations: A Meta-Analysis.
abstract: BACKGROUND
  Genetic variations in the IL-27 gene have been proven to be associated with various types of human cancers and diseases. The purpose of the current study was to clarify the associations of the IL-27 rs153109 A>G and rs181206 T>C variants with human diseases using a meta-analysis study.
  
  
  METHODS
  A comprehensive electronic and manual search was carried out to find potential eligible studies. The effect size was represented by the unadjusted odds ratios (ORs). A 95% confidence interval (95%CI) was tested for the pooled OR using the Z test.
  
  
  RESULTS
  A total of 17 case-control studies (cases=4185, healthy controls=4077) were included in our study. Our study showed that the carriers of the rs181206 T>C and rs153109 A>G polymorphism in the IL-27 gene have elevated risks of diseases in the allele model (rs181206 T>C: OR=0.76, 95%CI=0.69~0.84, P<0.001; rs153109 A>G: OR=0.85, 95%CI=0.76~0.94, P=0.002) and dominant model (rs181206 T>C: OR=0.77, 95%CI=0.69~0.87, P<0.001; rs153109 A>G: OR=0.84, 95%CI=0.71~0.99, P=0.033). Disease type-stratified subgroup analysis yielded increased risk of related diseases in IL-27 rs181206 T>C carriers in the allele model in immune thrombocytopenia (ITP), asthma, and esophageal cancer (EC) subgroups (ITP: OR=0.69, 95%CI=0.53~0.88, P=0.004; asthma: OR=0.60, 95%CI=0.41~0.89, P=0.010; EC: OR=0.79, 95%CI=0.64~0.97, P=0.026); and IL-27 rs153109 A>G polymorphism was remarkably associated with the increased risk of related diseases in the allele model in ovarian cancer (OC), systemic lupus erythematosus (SLE), tuberculosis (TB), ulcerative colitis (UC), and chronic obstructive pulmonary disease (COPD) subgroups (all P<0.05).
  
  
  CONCLUSIONS
  Our results indicate that the genetic polymorphisms of IL-27 rs153109 and rs181206 may be involved in the progression of human cancers and diseases, especially of TB, UC, COPD, OC, and ITP.
authors.affiliation: The Second department of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an , China (mainland).
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Nanchang University, Jiangxi Medical College, Nanchang , China (mainland).
authors.forename: An-Di
authors.initials: AD
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D007378:Interleukins; C464565:MYDGF protein, human