title: Evaluation of bishexadecyltrimethyl ammonium palladium tetrachloride based dual functional colloidal carrier as an antimicrobial and anticancer agent.
abstract: We have developed a dual function carrier using bishexadecyltrimethyl ammonium palladium tetrachloride, which has anticancer as well as antibacterial activity, using a ligand insertion method with a simple and easy work procedure. The complex is prepared by a simple and cost effective method using hexadecyltrimethyl ammonium chloride and palladium chloride under controlled stoichiometry. Herein, we report the aggregation (self assembly) of the metallosurfactant having palladium as a counter ion, in aqueous medium along with its binding affinity with bovine serum albumin. The palladium surfactant has exhibited excellent antimicrobial efficacy against fungus and bacteria (both Gram-positive and Gram-negative bacteria). Cytotoxicity of palladium surfactant against cancerous (Human leukemia HL-60, pancreatic MIA-Pa-Ca-2 and prostate cancer PC-3) and healthy cells (fR2 human breast epithelial cells) was also evaluated using MTT assay. The present dual functional moiety shows a low IC50 value and has potential to be used as an anticancer agent. Our dual function carrier which itself possesses antimicrobial and anticancer activity represents a simple and effective system and can also be utilized as a drug carrier in the future.
authors.affiliation: Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160 014, India. gurpreet14@pu.ac.in.
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Kaur
authors.affiliation: Department of Bio and Nano Technology, Guru Jambheshwar University of Science & Technology, Hisar 125 001, Haryana, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Bio and Nano Technology, Guru Jambheshwar University of Science & Technology, Hisar 125 001, Haryana, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Dilbaghi
authors.affiliation: Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160 014, India. gurpreet14@pu.ac.in.
authors.forename: Baljinder
authors.initials: B
authors.lastname: Kaur
authors.affiliation: Department of Bio and Nano Technology, Guru Jambheshwar University of Science & Technology, Hisar 125 001, Haryana, India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Kant
authors.affiliation: Division of Cancer Pharmacology, Indian Institute of Integrative Medicine, CSIR, Jammu, India.
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Guru
authors.affiliation: Division of Cancer Pharmacology, Indian Institute of Integrative Medicine, CSIR, Jammu, India.
authors.forename: Shashi
authors.initials: S
authors.lastname: Bhushan
authors.affiliation: Quality Control & Quality Assurance Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
authors.forename: Sundeep
authors.initials: S
authors.lastname: Jaglan
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002417:Cattle; D045744:Cell Line, Tumor; D003102:Colloids; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D003102:Colloids; D009942:Organometallic Compounds; D012710:Serum Albumin, Bovine; D010165:Palladium