title: OXA-48 Producing Klebsiella pneumoniae in a Household Contact of a Previously Infected Patient: Person-to-Person Transmission or Coincidental Community Acquisition?
abstract: We reported a woman with urinary-tract infection caused by OXA-48 producing Klebsiella pneumoniae. Using molecular techniques, we showed that she might acquire this bacterium from another family member who lived in the same house. The two isolates, although different by pulsed-field gel electrophoresis and multilocus sequence typing, carried blaOXA-48 in a similar IncL/M plasmid. This case report shows that community spreading of carbapenemase producing Enterobacteriaceae occurs in the low endemic area not only in nosocomial setting but also in the community.
authors.affiliation: 1 Department of Microbiology and Infection Control, Universitair Ziekenhuis Brussel , Brussels, Belgium .
authors.forename: Erlangga
authors.initials: E
authors.lastname: Yusuf
authors.affiliation: 2 National Reference Centre for Monitoring of Antimicrobial Resistance in Gram-Negative Bacteria, CHU Dinant Godinne , UCL Namur, Yvoir, Belgium .
authors.forename: Te-Din
authors.initials: TD
authors.lastname: Huang
authors.affiliation: 1 Department of Microbiology and Infection Control, Universitair Ziekenhuis Brussel , Brussels, Belgium .
authors.forename: Anneleen
authors.initials: A
authors.lastname: Schallier
authors.affiliation: 3 Health Inspection (Service de l'Inspection de l'Hygiène de la Commission Communautaire Commune) , Brussels, Belgium .
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Trémérie
authors.affiliation: 4 Department of Internal Medicine, Universitair Ziekenhuis Brussel , Brussels, Belgium .
authors.forename: Rembert
authors.initials: R
authors.lastname: Mertens
authors.affiliation: 5 Healthcare-Associated Infections and Antimicrobial Resistance, Public Health and Surveillance, Scientific Institute of Public Health (WIV-ISP) , Brussels, Belgium .
authors.forename: Beatrice
authors.initials: B
authors.lastname: Jans
authors.affiliation: 2 National Reference Centre for Monitoring of Antimicrobial Resistance in Gram-Negative Bacteria, CHU Dinant Godinne , UCL Namur, Yvoir, Belgium .
authors.forename: Youri
authors.initials: Y
authors.lastname: Glupczynski
authors.affiliation: 1 Department of Microbiology and Infection Control, Universitair Ziekenhuis Brussel , Brussels, Belgium .
authors.forename: Denis
authors.initials: D
authors.lastname: Piérard
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001530:Belgium; D015780:Carbapenems / Q000494:pharmacology; D017714:Community-Acquired Infections; D004269:DNA, Bacterial / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D005191:Family Characteristics; D005260:Female; D015870:Gene Expression; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D004269:DNA, Bacterial; D001618:beta-Lactamases; C108449:oxacillinase