title: [Posterior Reversible Encephalopathy Syndrome Associated with Cancer Therapy].
abstract: Posterior reversible encephalopathy syndrome(PRES)is a subacute neurological syndrome typically manifesting with headache, cortical blindness, and seizures. This syndrome is associated with risk factors such as malignant hypertension, eclampsia, and renal failure. Numerous case reports depict its occurrence in cancer patients. The direct causal mechanisms of PRES in cancer patients have not yet been identified. Cytotoxic chemotherapy may cause direct endothelial damage, which would impact the blood brain barrier. Angiogenesis inhibitors also cause elevation in blood pressure;this is significant, because PRES onset may be solely related to hypertension. An increased number of case reports involving new molecular targeted agent suggests that incidence of PRES as an oncological emergency may increase in the future.
authors.affiliation: Division of Neurosurgery, Shizuoka Cancer Center.
authors.forename: Koichi
authors.initials: K
authors.lastname: Mitsuya
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nakasu
authors.forename: Nakamasa
authors.initials: N
authors.lastname: Hayashi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yasui
authors.forename: Takashi
authors.initials: T
authors.lastname: Ikeda
authors.forename: Shiho
authors.initials: S
authors.lastname: Kuji
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Onozawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Endo
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D054038:Posterior Leukoencephalopathy Syndrome / Q000209:etiology* / Q000473:pathology