title: Genetic Variants in the Wnt Signaling Pathway Are Not Associated with Survival Outcome of Non-Small Cell Lung Cancer in a Korean Population.
abstract: Recently, genetic variants in the WNT signaling pathway have been reported to affect the survival outcome of Caucasian patients with early stage non-small cell lung cancer (NSCLC). We therefore attempted to determine whether these same WNT signaling pathway gene variants had similar impacts on the survival outcome of NSCLC patients in a Korean population. A total of 761 patients with stages I-IIIA NSCLC were enrolled in this study. Eight variants of WNT pathway genes were genotyped and their association with overall survival and disease-free survival were analyzed. None of the eight variants were significantly associated with overall survival or disease-free survival. There were no differences in survival outcome after stratifying the subjects according to age, gender, smoking status, and histological type. These results suggest that genetic variants in the WNT signaling pathway may not affect the survival outcome of NSCLC in a Korean population.
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea .
authors.forename: Seung Soo
authors.identifier: 0000-0002-7309-9254
authors.initials: SS
authors.lastname: Yoo
authors.affiliation: Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea .
authors.forename: Mi Jeong
authors.identifier: 0000-0002-9504-334X
authors.initials: MJ
authors.lastname: Hong
authors.affiliation: Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea .
authors.forename: Jin Eun
authors.identifier: 0000-0001-7833-2257
authors.initials: JE
authors.lastname: Choi
authors.affiliation: Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea .
authors.forename: Jang Hyuck
authors.identifier: 0000-0001-5537-3013
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea .
authors.forename: Sun Ah
authors.identifier: 0000-0002-8088-9764
authors.initials: SA
authors.lastname: Baek
authors.affiliation: Department of Preventive Medicine, Kyungpook National University School of Medicine, Daegu, Korea .
authors.forename: Won Kee
authors.identifier: 0000-0003-4217-5792
authors.initials: WK
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea .
authors.forename: So Yeon
authors.identifier: 0000-0002-1868-7715
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea .
authors.forename: Shin Yup
authors.identifier: 0000-0002-2121-7335
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea .
authors.forename: Jaehee
authors.identifier: 0000-0001-8111-7320
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea .
authors.forename: Seung Ick
authors.identifier: 0000-0002-7246-0909
authors.initials: SI
authors.lastname: Cha
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea .
authors.forename: Chang Ho
authors.identifier: 0000-0002-1550-5752
authors.initials: CH
authors.lastname: Kim
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Seoul National University School of Medicine, Seoul, Korea .
authors.forename: Sukki
authors.identifier: 0000-0002-9309-8865
authors.initials: S
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.; Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Jae Yong
authors.identifier: 0000-0001-7993-4495
authors.initials: JY
authors.lastname: Park
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D003710:Demography; D018572:Disease-Free Survival; D005260:Female; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea; D012907:Smoking; D060449:Wnt Signaling Pathway / Q000235:genetics*
keywords: Lung Neoplasms; Polymorphisms; Survival; WNT