title: Roles of the kidney in the formation, remodeling and repair of bone.
abstract: The relationship between the kidney and bone is highly complex, and the kidney plays an important role in the regulation of bone development and metabolism. The kidney is the major organ involved in the regulation of calcium and phosphate homeostasis, which is essential for bone mineralization and development. Many substances synthesized by the kidney, such as 1,25(OH)2D3, Klotho, bone morphogenetic protein-7, and erythropoietin, are involved in different stages of bone formation, remodeling and repair. In addition, some cytokines which can be affected by the kidney, such as osteoprotegerin, sclerostin, fibroblast growth factor -23 and parathyroid hormone, also play important roles in bone metabolism. In this paper, we summarize the possible effects of these kidney-related cytokines on bone and their possible mechanisms. Most of these cytokines can interact with one another, constituting an intricate network between the kidney and bone. Therefore, kidney diseases should be considered among patients presenting with osteodystrophy and disturbances in bone and mineral metabolism, and treatment for renal dysfunction may accelerate their recovery.
authors.affiliation: Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing, 100853, People's Republic of China.|Medical College, NanKai University, Tianjin, 300071, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wei
authors.affiliation: Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing, 100853, People's Republic of China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing, 100853, People's Republic of China. xieyuansn@hotmail.com.
authors.forename: Yuansheng
authors.initials: Y
authors.lastname: Xie
mesh_terms: D055419:Bone Morphogenetic Protein 7 / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D017102:Fracture Healing; D005966:Glucuronidase / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology*; D000090265:Klotho Proteins; D010012:Osteogenesis / Q000502:physiology*; D010710:Phosphates / Q000378:metabolism
chemical_list: D055419:Bone Morphogenetic Protein 7; D010710:Phosphates; D005966:Glucuronidase; D000090265:Klotho Proteins; D002118:Calcium
keywords: 1,25(OH)2D3; Bone; Bone morphogenetic protein-7; Erythropoietin; Kidney; Klotho