title: E-Cigarettes for Immediate Smoking Substitution in Women Diagnosed with Cervical Dysplasia and Associated Disorders.
abstract: The aim of this study was to determine if 31 women with cervical dysplasia and associated conditions exacerbated by smoking would be successful substituting cigarettes with their choice of either nicotine replacement therapy (NRT) or electronic cigarettes (EC). Women received motivational interviewing and tried both NRT and ECs, choosing one method to use during a six-week intervention period. Daily cigarette consumption was measured at baseline, six, and 12 weeks, with differences analyzed by the Wilcoxon signed-rank test. Study analysis consisted only of women choosing to use ECs (29/31), as only two chose NRT. At the 12-week follow-up, the seven day point prevalence abstinence from smoking was 28.6%, and the median number of cigarettes smoked daily decreased from 18.5 to 5.5 (p < 0.0001). The median number of e-cigarette cartridges used dropped from 21 at the six-week follow-up to 12.5 at the 12-week follow-up. After initiating EC use, women at risk for cervical cancer were able to either quit smoking or reduce the number of cigarettes smoked per day. Although a controlled trial with a larger sample size is needed to confirm these initial results, this study suggests that using ECs during quit attempts may reduce cigarette consumption.
authors.affiliation: Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. shirley-james@ouhsc.edu.
authors.forename: Shirley A
authors.initials: SA
authors.lastname: James
authors.affiliation: Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. emeier@ostatemail.okstate.edu.
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Meier
authors.affiliation: Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. theodore-wagener@ouhsc.edu.
authors.forename: Theodore L
authors.initials: TL
authors.lastname: Wagener
authors.affiliation: Oklahoma University Physicians, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. katie-smith@ouhsc.edu.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Smith
authors.affiliation: Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. barbara-neas@ouhsc.edu.
authors.forename: Barbara R
authors.initials: BR
authors.lastname: Neas
authors.affiliation: Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. laura-beebe@ouhsc.edu.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Beebe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D066300:Electronic Nicotine Delivery Systems / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012907:Smoking / Q000628:therapy*; D016540:Smoking Cessation / Q000379:methods*; D061485:Tobacco Use Cessation Devices / Q000706:statistics & numerical data*; D014481:United States; D002578:Uterine Cervical Dysplasia / Q000517:prevention & control*; D055815:Young Adult
keywords: EC; cervical dysplasia; electronic cigarette; electronic nicotine delivery device; smoking cessation; vaping