title: Data on megakaryocytes in the bone marrow of mice exposed to formaldehyde.
abstract: Previously, we reported that occupational exposure to formaldehyde (FA) exposure in factory workers reduced platelet counts, http://dx.doi.org/10.1158/1055-9965.EPI-09-0762[1], while exposure in mice increased platelet counts http://dx.doi.org/10.1371/journal.pone.0074974[2]. Bone marrow megakaryocyte (MK) numbers were also increased in exposed mice, as determined qualitatively. The data presented here are from a quantitative evaluation of MK numbers in the bone marrow histopathological slides from the previous FA exposure experiments in mice. Bone marrow slides were prepared using a single 5 μm section of femur from 2 mice randomly selected from each exposure group (n=9) treated with 0, 0.5 and 3.0 mg/m(3) FA by nose-only inhalation. MKs were systemically counted and average MK frequency was calculated as the total MK per slide divided by the number of fields evaluated. Data are presented visually as microscopy views and graphically as MK frequency.
authors.affiliation: Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, China.
authors.forename: Yuchao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, United States.
authors.forename: Cliona M
authors.initials: CM
authors.lastname: McHale
authors.affiliation: Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yang
authors.affiliation: Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, China.
authors.forename: Shumao
authors.initials: S
authors.lastname: Ding
authors.affiliation: Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, United States.
authors.forename: Luoping
authors.initials: L
authors.lastname: Zhang