title: KLF17 Expression in Colorectal Carcinoma and Its Clinical Significance.
abstract: OBJECTIVE
  To detect KLF17 expression in colorectal carcinoma (CRC) and to evaluate its effect on the prognosis of colorectal carcinoma.
  
  
  METHODS
  Immunohistochemistry was performed to detect the expression of KLF17 in CRC and matched pericarcinous tissue,and the relationship between KLF17 expression and disease-free survival (DFS) was analyzed.
  
  
  RESULTS
  Of 73 CRC patients, KLF17 expression was positive in 32 patients and negative in 41 patients. KLF17 expression rate was significantly lower in CRC tissue than in pericarcinous tissue (χ(2)=12.418, P=0.001). The DFS of KLF17-positive stage III colon cancer patients was (56.3±7.2) months (95% CI: 42-70 months), which was significantly longer than that [(32.3±5.5) months (95% CI: 22-43 months)] of KLF17-negative patients (P=0.039).
  
  
  CONCLUSIONS
  KLF17 expression decreases in CRC tissue, and a positivie KLF17 expression predicts a better prognosis in stage III CRC patients.
authors.affiliation: Department of Oncology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: He-li
authors.initials: HL
authors.lastname: Gao
authors.affiliation: Department of Oncology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhou
authors.affiliation: Department of Oncology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Oncology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Xue-lin
authors.initials: XL
authors.lastname: Dou
authors.affiliation: Department of Oncology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Mei
authors.initials: M
authors.lastname: Guan
authors.affiliation: Department of Oncology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Chun-mei
authors.initials: CM
authors.lastname: Bai
mesh_terms: D015179:Colorectal Neoplasms; D018572:Disease-Free Survival; D006801:Humans; D007150:Immunohistochemistry; D011379:Prognosis; D014157:Transcription Factors
chemical_list: C510638:KLF17 protein, human; D014157:Transcription Factors