title: Severe anemia due to parvovirus B19 in a silver haired boy.
abstract: Griscelli syndrome (GS) is a rare autosomal recessive immunodeficiency disorder in which the affected children present with characteristic silvery-white hairs. The hair microscopy of these children is characteristic and is helpful in differentiating GS from Chediak-Higashi syndrome which also presents with immunodeficiency and silver hairs. We report a 17-month-old boy with GS type 2 who presented with severe anemia. Bone marrow examination of the child suggested parvovirus B19 as the cause of severe anemia, which was later confirmed by DNA polymerase chain reaction.
authors.affiliation: Department of Pediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Nishant
authors.initials: N
authors.lastname: Verma
authors.forename: Archana
authors.initials: A
authors.lastname: Kumar
authors.forename: Rashmi
authors.initials: R
authors.lastname: Kushwaha
mesh_terms: D000740:Anemia / Q000209:etiology* / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology; D003955:Diagnostic Tests, Routine; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications*; D008297:Male; D008853:Microscopy; D010322:Parvoviridae Infections / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D016116:Piebaldism / Q000150:complications*; D016133:Polymerase Chain Reaction; D000081207:Primary Immunodeficiency Diseases