title: [Influence of Professional Contact with Plutonium-239 on Indicators of the Immune Status of the Personnel at Siberian Chemical Plant].
abstract: The results of the examination and monitoring of the personnel at the Siberian Chemical Plant (SChP) and adult population of Seversk are presented. The results of primary examination of the personnel who professionally contact the ionizing radiation (IR) from external sources and incorporated 239Pu showed that clinical symptoms of dysfunction of the immune system manifested themselves with a frequency of 75.30%. Infectious-inflammatory diseases (46.95%) and the combined pathology of infectious and allergic character (20.12%) were the most widespread. The allergic diseases (AD) without manifestations of an infectious component were observed not often (7.62%). The monitoring which was carried out for 10 years revealed a decrease in a percentage of persons with clinical signs of disorders of the immune system up to 60.68% among the personnel at the Chemical-Steel Plant and even more among the whole group of the studied personnel at SChP--49.68% (389 : 783). Among the population their frequency made up 51.78%. Features of clinical manifestations of dysfunction ofthe immune system depending on accumulation of 239Pu in the organism are established. Similar dynamics of infectious and infectious and allergic syndromes is revealed when the activity of 239Pu is 40 nCi. AD frequency reliably increased .when the activity of 239Pu is 20 nCi, but if accumulation is higher than 20-40 nCi it decreases and again increases when the activity is over 40 nCi. Pathologies of infectious and allergic genesis are most often observed when the content of 239Pu in an organism is over 40 nCi. Indicators of the immune status (IS) of the personnel at SChP with incorporated 239Pu are analyzed. 59 people--carriers of 239Pu and 408 people without 239Pu accumulated in an organism are examined. In comparison with the control, IS indicators characteristic for all dose loading groups are revealed: increase of lymphocytes, existence of dissociation in indicators of relative and absolute values of the T-cellular link, CD16+56+(-) NK-cells and B-lymphocytes with increase of absolute values, decrease in markers of activation of HLA-DR+ and CD95+, increase of B-lymphocytes and low level of serum IgM. Features of IS in comparison with the group of the personnel with the absence of 239Pu in an organism and indicators of IS which depend on the activity of 239Pu are established. Among them are a decrease in the percentage of persons with increased number of lymphocytes with increased beam loading; increase of NK-T-cells when the activity of 239Pu is 10-20 nCi and the highest value at doses over40 nCi; the dynamics of CD16+56(+)-lymphocytes with the increase of the contents and a percentage of persons with the increase of the activity above 40 nCi; the highest frequenc of a regulatory imbalance with high frequency decrease of CD8(+)-T-lymphocytes at the content of 239Pu > 0-10 nCi; decrease in indicators of B-lymphocytes and serum IgA with an increase in the activity of 239Pu with the lowest values under internal radiation over 40 nCi; decrease in the percentage of persons with a weakening expression of HLA-DR+ with the increase in dose loading.
authors.forename: I V
authors.initials: IV
authors.lastname: Oradovskaya
authors.forename: T T
authors.initials: TT
authors.lastname: Radzivil
mesh_terms: D002617:Chemical Industry; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D055633:Immune System Phenomena / Q000528:radiation effects*; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects; D008297:Male; D015166:Monitoring, Immunologic / Q000379:methods*; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D011005:Plutonium / Q000009:adverse effects* / Q000032:analysis; D015995:Prevalence; D000069079:Radiation Exposure / Q000009:adverse effects* / Q000032:analysis; D012800:Siberia
chemical_list: D011005:Plutonium