title: Citation Sentiment Analysis in Clinical Trial Papers.
abstract: In scientific writing, positive credits and negative criticisms can often be seen in the text mentioning the cited papers, providing useful information about whether a study can be reproduced or not. In this study, we focus on citation sentiment analysis, which aims to determine the sentiment polarity that the citation context carries towards the cited paper. A citation sentiment corpus was annotated first on clinical trial papers. The effectiveness of n-gram and sentiment lexicon features, and problem-specified structure features for citation sentiment analysis were then examined using the annotated corpus. The combined features from the word n-grams, the sentiment lexicons and the structure information achieved the highest Micro F-score of 0.860 and Macro-F score of 0.719, indicating that it is feasible to use machine learning methods for citation sentiment analysis in biomedical publications. A comprehensive comparison between citation sentiment analysis of clinical trial papers and other general domains were conducted, which additionally highlights the unique challenges within this domain.
authors.affiliation: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Yaoyun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Wu
authors.affiliation: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Jingqi
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Xiao
authors.initials: X
authors.lastname: Dong
authors.affiliation: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Xu
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D011642:Publications