title: Giant seminal vesicle cyst: an unusual site for a malignant extragastrointestinal stromal tumour.
abstract: Mesenchymal tumours with clinicopathological and molecular profiles similar to gastrointestinal stromal tumours (GISTs) are, on occasion, found in extragastrointestinal locations. Extra GIST (EGIST) is a singular occurrence in the genitourinary tract. A 30-year-old man, catheterised following urinary retention, was found to have a complex pelvic retrovesical cyst on imaging. At operation, origin from the right seminal vesicle was evident with histopathology confirming a GIST. The patient received adjuvant therapy with tyrosine kinase inhibitor and is currently disease free at 2 years. This is only the second report of an EGIST at this anatomic locale. The current literature presents significant uncertainty in defining the true origin of EGISTs, particularly those in the pelvis. We propose the designation origin indeterminate stromal tumour (OIST), to facilitate disambiguation and advance accurate profiling of EGIST; a subject in evolution.
authors.affiliation: Department of Urology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
authors.forename: Ranil Johann
authors.identifier: http://orcid.org/0000-0002-0770-3839
authors.initials: RJ
authors.lastname: Boaz
authors.affiliation: Department of Urology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
authors.forename: Arun Philip
authors.initials: AP
authors.lastname: George
authors.affiliation: Department of Pathology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
authors.forename: Ramani Manoj
authors.initials: RM
authors.lastname: Kumar
authors.affiliation: Department of Urology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
authors.forename: Antony
authors.initials: A
authors.lastname: Devasia
mesh_terms: D000328:Adult; D017024:Chemotherapy, Adjuvant; D005834:Genital Neoplasms, Male / Q000000981:diagnostic imaging* / Q000628:therapy; D006801:Humans; D008297:Male; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D012669:Seminal Vesicles / Q000473:pathology* / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D047428:Protein Kinase Inhibitors