title: Soluble CD40L is associated with insulin resistance, but not with glucose tolerance in obese nondiabetic patients.
abstract: OBJECTIVE
  The soluble platelet secreted ligand CD40 (sCD40L) has a role in atherosclerosis progression. The aim of the present study was to investigate the link between the levels of sCD40L and some classical cardiovascular risk factors in obese nondiabetic patients.
  
  
  METHODS
  In the present cross-sectional study, we included76 patients with mean age of 50.7 ± 10.7 years. Oral glucose tolerance test (OGTT) was performed in all participants and levels of sCD40L were measured using enzyme-linked immunosorbent assay (ELISA) method.
  
  
  RESULTS
  We found significantly higher levels in patients with insulin resistance compared to those without (6.4 ± 3.7 vs. 4.1 ± 2.4 ng/ml, р = 0.025) and only a tendency toward higher levels in prediabetes compared to normoglycemic patients (5.9 ± 3.6 vs. 5.3 ± 3.4 ng/ml). There was no correlation between sCD40L and platelet count, systolic and diastolic blood pressure and lipid profile.
  
  
  CONCLUSIONS
  The main factor for increased sCD40L plasma levels was the presence of insulin resistance and not the state of glucose tolerance.
authors.affiliation: a Clinic of Endocrinology, University Hospital "Alexandrovska", Medical University-Sofia , Sofia , Bulgaria , and.
authors.forename: Antoaneta
authors.initials: A
authors.lastname: Gateva
authors.affiliation: a Clinic of Endocrinology, University Hospital "Alexandrovska", Medical University-Sofia , Sofia , Bulgaria , and.
authors.forename: Yavor
authors.initials: Y
authors.lastname: Assyov
authors.affiliation: b Central Clinical Laboratory, University Hospital "Alexandrovska", Medical University-Sofia , Sofia , Bulgaria.
authors.forename: Adelina
authors.initials: A
authors.lastname: Tsakova
authors.affiliation: a Clinic of Endocrinology, University Hospital "Alexandrovska", Medical University-Sofia , Sofia , Bulgaria , and.
authors.forename: Zdravko
authors.initials: Z
authors.lastname: Kamenov
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood*; D023201:CD40 Ligand / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D011236:Prediabetic State / Q000097:blood / Q000175:diagnosis / Q000209:etiology*
chemical_list: D015415:Biomarkers; D023201:CD40 Ligand
keywords: Atherosclerosis; cardiovascular complications; prediabetes