title: Protein Partners of α-Synuclein in Health and Disease.
abstract: α-synuclein is normally situated in the nerve terminal but it accumulates and aggregates in axons and cell bodies in synucleinopathies such as Parkinson's disease. The conformational changes occurring during α-synucleins aggregation process affects its interactions with other proteins and its subcellular localization. This review focuses on interaction partners of α-synuclein within different compartments of the cell with a focus on those preferentially binding aggregated α-synuclein. The aggregation state of α-synuclein also affects its catabolism and we hypothesize impaired macroautophagy is involved neuronal excretion of α-synuclein species responsible for the prion-like spreading of α-synuclein pathology.
authors.affiliation: DANDRITE-Danish Research Institute of Translational Neuroscience & Department of Biomedicine, University of Aarhus, Aarhus, Denmark.
authors.forename: Louise Berkhoudt
authors.initials: LB
authors.lastname: Lassen
authors.affiliation: DANDRITE-Danish Research Institute of Translational Neuroscience & Department of Biomedicine, University of Aarhus, Aarhus, Denmark.
authors.forename: Lasse
authors.initials: L
authors.lastname: Reimer
authors.affiliation: DANDRITE-Danish Research Institute of Translational Neuroscience & Department of Biomedicine, University of Aarhus, Aarhus, Denmark.
authors.forename: Nelson
authors.initials: N
authors.lastname: Ferreira
authors.affiliation: DANDRITE-Danish Research Institute of Translational Neuroscience & Department of Biomedicine, University of Aarhus, Aarhus, Denmark.
authors.forename: Cristine
authors.initials: C
authors.lastname: Betzer
authors.affiliation: DANDRITE-Danish Research Institute of Translational Neuroscience & Department of Biomedicine, University of Aarhus, Aarhus, Denmark.
authors.forename: Poul Henning
authors.initials: PH
authors.lastname: Jensen
mesh_terms: D000818:Animals; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology*; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein
keywords: Lewy Body; Parkinson's disease; dementia; neurodegeneration; protein interaction; proteomics; α-synuclein