title: Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits.
abstract: We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas. Localized intracranial deposits of non-amyloid immunoglobulin may rarely mimic space-occupying intracranial neoplasms and should be considered in the differential diagnosis.
authors.affiliation: Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene Street, Suite 12D, Baltimore, MD 21201, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Hersh
authors.affiliation: Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Petra
authors.initials: P
authors.lastname: Houbova
authors.affiliation: Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Rudolph J
authors.initials: RJ
authors.lastname: Castellani
authors.affiliation: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Fausto J
authors.initials: FJ
authors.lastname: Rodriguez
authors.affiliation: Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Minesh P
authors.initials: MP
authors.lastname: Mehta
authors.affiliation: Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene Street, Suite 12D, Baltimore, MD 21201, USA; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: gwoodworth@smail.umaryland.edu.
authors.forename: Graeme F
authors.initials: GF
authors.lastname: Woodworth
mesh_terms: D000328:Adult; D000682:Amyloid; D001932:Brain Neoplasms / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D007136:Immunoglobulins; D008297:Male; D009422:Nervous System Diseases / Q000000981:diagnostic imaging* / Q000209:etiology
chemical_list: D000682:Amyloid; D007136:Immunoglobulins
keywords: Amyloid; Immunoglobulin; Mass spectrometry