title: Clinical results of ab interno trabeculotomy using the Trabectome in patients with pigmentary glaucoma compared to primary open angle glaucoma.
abstract: BACKGROUND
  To evaluate outcomes of Trabectome on pigmentary glaucoma (PG) patients compared to matched controls with primary open angle glaucoma (POAG).
  
  
  METHODS
  Prospective comparison study PARTICIPANTS: A total of 101 POAG cases were matched with 101 PG cases.
  
  
  METHODS
  Data of the patients diagnosed with PG or POAG was obtained from Trabectome Study Group Database. A one-to-one exact matching was performed between POAG and pigmentary cases based on type of surgery, baseline IOP and baseline number of glaucoma medications. IOP and number of glaucoma medications were compared between groups by Wilcoxon test. Success was defined as IOP ≤ 21 mmHg, at least 20% IOP reduction from baseline for two consecutive visits after 3 months and no secondary surgery.
  
  
  METHODS
  Success rate after Trabectome surgery in PG patients.
  
  
  RESULTS
  Baseline IOP for PG is 24.4 ± 7.7 mmHg and 24.2 ± 7.5 mmHg for POAG (P = 1.0), while baseline number of glaucoma medications was 2.8 ± 1.2 mmHg for PG and 2.8 ± 1.2 mmHg for POAG (P = 1.0). Postoperative IOP values at 12 months were 17.1 ± 5.0 for PG cases and 15.9 ± 4.2 mmHg for POAG cases. Postoperative number of glaucoma medications at 12 month was 2.1 ± 1.4 in PG cases and 2.4 ± 1.3 in POAG cases. There was no statistically significant difference between groups in IOP or number of medications at any time point. Survival rate at 12 months was 92% and 86% in PG and POAG, respectively (P = 0.47). Six PG cases and nine POAG cases required secondary surgery.
  
  
  CONCLUSIONS
  Trabectome provides similar outcomes to PG patients and POAG patients.
authors.affiliation: Doheny Eye Institute, Doheny Image Reading Center, Los Angeles, California, USA. HAkil@doheny.org.
authors.forename: Handan
authors.initials: H
authors.lastname: Akil
authors.affiliation: Doheny Eye Institute, Doheny Image Reading Center, Los Angeles, California, USA.|Department of Ophthalmology, David Geffen School of Medicine, Los Angeles, California, USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Chopra
authors.affiliation: Doheny Eye Institute, Doheny Image Reading Center, Los Angeles, California, USA.|Department of Ophthalmology, David Geffen School of Medicine, Los Angeles, California, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Huang
authors.affiliation: Department of Ophthalmology, University of Pittsburgh, Pennsylvania, USA.
authors.forename: Nils
authors.initials: N
authors.lastname: Loewen
authors.affiliation: University of California, San Diego School of Medicine, La Jolla, California, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Noguchi
authors.affiliation: Doheny Eye Institute, Doheny Image Reading Center, Los Angeles, California, USA.|Department of Ophthalmology, David Geffen School of Medicine, Los Angeles, California, USA.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Francis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011446:Prospective Studies; D014065:Tonometry, Ocular; D014129:Trabecular Meshwork / Q000601:surgery*; D014130:Trabeculectomy
chemical_list: D000959:Antihypertensive Agents
keywords: Trabectome; pigmentary glaucoma; primary open-angle glaucoma; success rate