title: A Drug-Free Zone--Lymph Nodes as a Safe Haven for HIV.
abstract: Understanding where and how the HIV latent reservoir persists is essential for developing rational HIV cure strategies. In a recent paper in Nature, Lorenzo-Redondo et al. (2016) demonstrate that HIV persists and actively evolves within lymph nodes due to low antiretroviral drug penetration, revealing the need to target these drug-privileged sites.
authors.affiliation: The Ragon Institute of MGH, MIT & Harvard, 400 Technology Square, Cambridge, MA 02139, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Licht
authors.affiliation: The Ragon Institute of MGH, MIT & Harvard, 400 Technology Square, Cambridge, MA 02139, USA. Electronic address: galter@partners.org.
authors.forename: Galit
authors.initials: G
authors.lastname: Alter
mesh_terms: D002353:Carrier State / Q000188:drug therapy* / Q000821:virology*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1 / Q000254:growth & development*; D006801:Humans; D019562:Viral Load; D014779:Virus Replication