title: Imipenem/cilastatin-induced acute eosinophilic pneumonia.
abstract: Drugs, toxins, and infections are known to cause acute eosinophilic pneumonia. Daptomycin and minocycline are the commonly reported antibiotics associated with acute eosinophilic pneumonia. In this study, we present a case of imipenem/cilastatin-induced acute eosinophilic pneumonia. The patient presented with fever, acute hypoxic respiratory distress, and diffuse ground-glass opacities on the chest CT a day after the initiation of imipenem/cilastatin. Patient also developed peripheral eosinophilia. A reinstitution of imipenem/cilastatin resulted in recurrence of the signs and symptoms. A bronchoscopy with bronchoalveolar lavage showed 780 nucleated cells/mm(3) with 15% eosinophil. The patient's clinical condition improved significantly after the discontinuation of imipenem/cilastatin therapy and the treatment with corticosteroid.
authors.affiliation: Department of Medicine, Crozer Chester Medical Center, Upland, Pennsylvania, USA.
authors.forename: Kap Sum
authors.initials: KS
authors.lastname: Foong
authors.affiliation: Department of Radiology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
authors.forename: Ashley
authors.initials: A
authors.lastname: Lee
authors.affiliation: Department of Radiology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
authors.forename: Marijeta
authors.initials: M
authors.lastname: Pekez
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Crozer-Chester Medical Center, Upland, Pennsylvania, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Bin
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D015377:Cilastatin / Q000009:adverse effects* / Q000627:therapeutic use; D000077728:Cilastatin, Imipenem Drug Combination; D004338:Drug Combinations; D005260:Female; D006801:Humans; D015378:Imipenem / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D004338:Drug Combinations; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination