title: Sequence comparison of six human microRNAs genes between tuberculosis patients and healthy individuals.
abstract: OBJECTIVE
  MicroRNAs (miRNAs) play an important role in diseases development. Therefore, human miRNAs may be able to inhibit the survival of Mycobacterium tuberculosis (Mtb) in the human host by targeting critical genes of the pathogen. Mutations within miRNAs can alter their target selection, thereby preventing them from inhibiting Mtb genes, thus increasing host susceptibility to the disease.
  
  
  METHODS
  This study was undertaken to investigate the genetic association of pulmonary tuberculosis (TB) with six human miRNAs genes, namely, hsa-miR-370, hsa-miR-520d, hsa-miR-154, hsa-miR-497, hsa-miR-758, and hsa-miR-593, which have been predicted to interact with Mtb genes. The objective of the study was to determine the possible sequence variation of selected miRNA genes that are potentially associated with the inhibition of critical Mtb genes in TB patients.
  
  
  RESULTS
  The study did not show differences in the sequences compared with healthy individuals without antecedents of TB.
  
  
  CONCLUSIONS
  This result could have been influenced by the sample size and the selection of miRNA genes, which need to be addressed in future studies.
authors.affiliation: School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors.forename: A
authors.initials: A
authors.lastname: Amila
authors.affiliation: Institute for Research in Molecular Medicine Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors.forename: A
authors.initials: A
authors.lastname: Acosta
authors.affiliation: School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors.forename: M E
authors.initials: ME
authors.lastname: Sarmiento
authors.affiliation: School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors.forename: Siti
authors.initials: S
authors.lastname: Suraiya
authors.affiliation: School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors.forename: Z
authors.initials: Z
authors.lastname: Zafarina
authors.affiliation: School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors.forename: S
authors.initials: S
authors.lastname: Panneerchelvam
authors.affiliation: School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia; Institute for Research in Molecular Medicine Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. Electronic address: norazmimn@usm.my.
authors.forename: M N
authors.initials: MN
authors.lastname: Norazmi
mesh_terms: D020869:Gene Expression Profiling; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000502:physiology; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology
chemical_list: C561122:MIRN154 microRNA, human; C526503:MIRN370 microRNA, human; C559640:MIRN497 microRNA, human; C575048:MIRN520 microRNA, human; C577650:MIRN593 microRNA, human; C569441:MIRN758 microRNA, human; D035683:MicroRNAs
keywords: Mycobacterium tuberculosis; Tuberculosis; microRNAs