title: A Low-Cost Method for Multiple Disease Prediction.
abstract: Recently, in response to the rising costs of healthcare services, employers that are financially responsible for the healthcare costs of their workforce have been investing in health improvement programs for their employees. A main objective of these so called "wellness programs" is to reduce the incidence of chronic illnesses such as cardiovascular disease, cancer, diabetes, and obesity, with the goal of reducing future medical costs. The majority of these wellness programs include an annual screening to detect individuals with the highest risk of developing chronic disease. Once these individuals are identified, the company can invest in interventions to reduce the risk of those individuals. However, capturing many biomarkers per employee creates a costly screening procedure. We propose a statistical data-driven method to address this challenge by minimizing the number of biomarkers in the screening procedure while maximizing the predictive power over a broad spectrum of diseases. Our solution uses multi-task learning and group dimensionality reduction from machine learning and statistics. We provide empirical validation of the proposed solution using data from two different electronic medical records systems, with comparisons to a statistical benchmark.
authors.affiliation: Graduate School of Business, Stanford University.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Bayati
authors.affiliation: Department of Electrical Engineering, Stanford University.
authors.forename: Sonia
authors.initials: S
authors.lastname: Bhaskar
authors.affiliation: Department of Electrical Engineering, Stanford University; Department of Statistics, Stanford University.
authors.forename: Andrea
authors.initials: A
authors.lastname: Montanari
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D002908:Chronic Disease / Q000191:economics / Q000517:prevention & control*; D003198:Computer Simulation; D057286:Electronic Health Records; D017048:Health Care Costs; D006293:Health Promotion / Q000191:economics; D006801:Humans; D008954:Models, Biological; D011237:Predictive Value of Tests; D018570:Risk Assessment / Q000379:methods*
chemical_list: D015415:Biomarkers