title: Encapsulation of CO2 into amorphous alpha-cyclodextrin powder at different moisture contents - Part 1: Encapsulation capacity and stability of inclusion complexes.
abstract: This study investigated the effects of water-induced crystallization of amorphous alpha-cyclodextrin (α-CD) powder on CO2 encapsulation at 0.4-1.6 MPa pressure for 1-72 h through the addition of water (to reach to 13, 15 and 17% wet basis, w.b.) into amorphous α-CD powder prior to the encapsulation. The results showed that the α-CD encapsulation capacity was over 1 mol CO2/mol α-CD after pressurizing for longer than 48 h. The encapsulated CO2 concentration by the addition of water was considerably higher (p<0.05) than that of amorphous α-CD powder (5.51% MC, w.b.) without an addition of water and that of crystalline α-CD powders under the same MC and encapsulation conditions. A comparison of CO2 release properties (75% relative humidity, 25 °C) from complexed powders prepared from amorphous and crystalline α-CD powders under the same conditions is also presented.
authors.affiliation: School of Agriculture and Food Sciences, The University of Queensland, QLD 4072, Australia.
authors.forename: Thao M
authors.initials: TM
authors.lastname: Ho
authors.affiliation: School of Chemical Engineering, The University of Queensland, St. Lucia, QLD 4072, Australia.
authors.forename: Tony
authors.initials: T
authors.lastname: Howes
authors.affiliation: School of Agriculture and Food Sciences, The University of Queensland, QLD 4072, Australia. Electronic address: b.bhandari@uq.edu.au.
authors.forename: Bhesh R
authors.initials: BR
authors.lastname: Bhandari
mesh_terms: D002245:Carbon Dioxide / Q000737:chemistry*; D003460:Crystallization; D004355:Drug Stability; D011208:Powders; D011312:Pressure; D014867:Water / Q000032:analysis / Q000737:chemistry; D047391:alpha-Cyclodextrins / Q000737:chemistry*
chemical_list: D011208:Powders; D047391:alpha-Cyclodextrins; D014867:Water; D002245:Carbon Dioxide; C032613:alpha-cyclodextrin
keywords: Amorphous α-cyclodextrin; Carbon dioxide; Complexed powder; Crystallization; Solid encapsulation