title: Triterpene alcohols and sterols from rice bran reduce postprandial hyperglycemia in rodents and humans.
abstract: Hyperglycemia is a major public health problem worldwide and there is increasing demand for prevention of postprandial hyperglycemia in diabetic, prediabetic, and healthy humans.
  
  
  
  We investigated whether rice bran and triterpene alcohol and sterol preparation (TASP) lowered hyperglycemia in mice and humans. Brown rice and white rice supplemented with TASP lowered the postprandial hyperglycemia in humans. TASP and its components (cycloartenol [CA], 24-methylene cycloartanol, β-sitosterol, and campesterol) decreased postprandial hyperglycemia in C57BL/6J mice. Glucose transport into everted rat intestinal sacs and human HuTu80 cells transfected with sodium-glucose cotransporter-1 (SGLT1) was significantly reduced by the addition of CA. Intracellular localization analysis suggested that SGLT1 translocation to the apical plasma membrane was inhibited when the cells were treated with CA.
  
  
  
  We demonstrated for the first time that TASP from rice bran lowered postprandial hyperglycemia in mice and humans. The smaller increase in blood glucose following TASP consumption may be due to the CA-induced decrease in glucose absorption from the intestine, which may be related to decreased membrane translocation of SGLT1.
authors.affiliation: Biological Science Laboratories, Kao Corporation, Tochigi, Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Okahara
authors.affiliation: Biological Science Laboratories, Kao Corporation, Tochigi, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Suzuki
authors.affiliation: Biological Science Laboratories, Kao Corporation, Tochigi, Japan.
authors.forename: Kohjiro
authors.initials: K
authors.lastname: Hashizume
authors.affiliation: Biological Science Laboratories, Kao Corporation, Tochigi, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Osaki
authors.affiliation: Biological Science Laboratories, Kao Corporation, Tochigi, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Shimotoyodome
mesh_terms: D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001835:Body Weight; D045744:Cell Line, Tumor; D002784:Cholesterol / Q000008:administration & dosage / Q000031:analogs & derivatives; D004043:Dietary Fiber / Q000008:administration & dosage*; D006801:Humans; D006943:Hyperglycemia / Q000178:diet therapy*; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012275:Oryza / Q000737:chemistry*; D010840:Phytosterols / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D016037:Single-Blind Method; D012855:Sitosterols / Q000008:administration & dosage; D051269:Sodium-Glucose Transporter 1 / Q000235:genetics / Q000378:metabolism; D013261:Sterols / Q000008:administration & dosage*; D014315:Triterpenes / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber; D007328:Insulin; D010840:Phytosterols; D012855:Sitosterols; D051269:Sodium-Glucose Transporter 1; D013261:Sterols; D014315:Triterpenes; C066041:24-methylene cycloartanol; C021273:campesterol; C025473:gamma-sitosterol; D002784:Cholesterol; C100089:cycloartenol
keywords: Cycloartenol; Hyperglycemia; Rice bran; SGLT1; Triterpene alcohol