title: Epigenetic and genetic variations at the TNNT1 gene locus are associated with HDL-C levels and coronary artery disease.
abstract: OBJECTIVE
  To assess whether epigenetic and genetic variations at the TNNT1 gene locus are associated with high-density lipoprotein cholesterol (HDL-C) and coronary artery disease (CAD). Patients, materials & methods: TNNT1 DNA methylation and c.-20G>A polymorphism were genotyped in subjects with and without familial hypercholesterolemia (FH).
  
  
  RESULTS
  Lower TNNT1 DNA methylation levels were independently associated with lower HDL-C levels and with the TNNT1 c.-20G>A polymorphism. In FH men, carriers of the TNNT1 c.-20G>A polymorphism had lower HDL-C levels and an increased risk of CAD compared with noncarriers. In non-FH men, a higher TNNT1 DNA methylation level was associated with CAD.
  
  
  CONCLUSIONS
  These results suggest that TNNT1 genetic and epigenetic variations are associated with HDL-C levels and CAD.
authors.affiliation: Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.|ECOGENE-21 & Lipid Clinic, Chicoutimi Hospital, Saguenay, QC G7H 5H6, Canada.
authors.forename: Simon-Pierre
authors.initials: SP
authors.lastname: Guay
authors.affiliation: Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.|ECOGENE-21 & Lipid Clinic, Chicoutimi Hospital, Saguenay, QC G7H 5H6, Canada.
authors.forename: Cécilia
authors.initials: C
authors.lastname: Légaré
authors.affiliation: ECOGENE-21 & Lipid Clinic, Chicoutimi Hospital, Saguenay, QC G7H 5H6, Canada.|Department of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada.
authors.forename: Diane
authors.initials: D
authors.lastname: Brisson
authors.affiliation: Centre de recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, QC G1V 0A6, Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Mathieu
authors.affiliation: Centre de recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, QC G1V 0A6, Canada.|Department of Molecular Medicine, Université Laval, Québec, QC G1V 0A6, Canada.
authors.forename: Yohan
authors.initials: Y
authors.lastname: Bossé
authors.affiliation: ECOGENE-21 & Lipid Clinic, Chicoutimi Hospital, Saguenay, QC G7H 5H6, Canada.|Department of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gaudet
authors.affiliation: Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.|ECOGENE-21 & Lipid Clinic, Chicoutimi Hospital, Saguenay, QC G7H 5H6, Canada.
authors.forename: Luigi
authors.initials: L
authors.lastname: Bouchard
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011792:Quebec; D020107:Troponin T / Q000235:genetics
chemical_list: D008076:Cholesterol, HDL; D020107:Troponin T
keywords: 19q13.42; DNA methylation; SNP; TNNT1 c.-20G>A polymorphism (rs9636153); cardiovascular disease; dyslipidemia; missing heritability