title: A Case of Salicylate Intoxication Complicated by Coagulopathy, Pulmonary Edema, and Pancreatitis.
abstract: The large availability of salicylic acid products makes them an often encountered source of poisoning in the emergency department. Even though in most cases the prognosis is good, with a low incidence of long-term morbidity and mortality, complications do occur, and some of those can be life threatening. We present an unusual case of salicylate intoxication in an adolescent in which several uncommon complications (severe coagulopathy, pulmonary edema, and pancreatitis) conjoined together. We review the literature and discuss the complications pathogenesis and differential diagnosis. We suggest that these potentially life-threatening complications be acknowledged, investigated, and rapidly treated.
authors.affiliation: 1Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH; and 2Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH.
authors.forename: Itay
authors.initials: I
authors.lastname: Ayalon
authors.forename: Matthew Noble
authors.initials: MN
authors.lastname: Alder
authors.forename: Travis Ryan
authors.initials: TR
authors.lastname: Langner
authors.forename: Einar Thor
authors.initials: ET
authors.lastname: Hafberg
authors.forename: Alexander Gerhard
authors.initials: AG
authors.lastname: Miethke
authors.forename: Jennifer Melissa
authors.initials: JM
authors.lastname: Kaplan
mesh_terms: D000138:Acidosis / Q000139:chemically induced; D000293:Adolescent; D000472:Alkalosis, Respiratory / Q000139:chemically induced / Q000628:therapy; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D053099:Azotemia / Q000139:chemically induced / Q000628:therapy; D001778:Blood Coagulation Disorders / Q000139:chemically induced* / Q000628:therapy; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced; D007010:Hyponatremia / Q000139:chemically induced / Q000628:therapy; D000860:Hypoxia / Q000139:chemically induced / Q000628:therapy; D010102:Oxygen Inhalation Therapy; D010195:Pancreatitis / Q000139:chemically induced*; D010949:Plasma; D011654:Pulmonary Edema / Q000139:chemically induced*; D020156:Salicylic Acid / Q000506:poisoning*; D014812:Vitamin K / Q000627:therapeutic use
chemical_list: D000933:Antifibrinolytic Agents; D014812:Vitamin K; D020156:Salicylic Acid