title: Synthetic Approaches To Construct the 6,8-DOBCO Framework in Natural Products.
abstract: 6,8-Dioxabicyclo[3.2.1]octane skeleton (6,8-DOBCO) is a very common structural motif in many biologically active natural products. This synopsis surveys various approaches used to access the 6,8-DOBCO framework present in natural products and summarizes total syntheses of 6,8-DOBCO-containing psoracorylifol B, ent-psoracorylifol C, didemniserinolipid B, and attenol B from our laboratory and others.
authors.affiliation: Department of Chemistry, The Hong Kong University of Science and Technology , Clearwater Bay, Kowloon, Hong Kong, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, The Hong Kong University of Science and Technology , Clearwater Bay, Kowloon, Hong Kong, China.
authors.forename: Rongbiao
authors.initials: R
authors.lastname: Tong
mesh_terms: D001686:Biological Phenomena; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D003500:Cyclization; D004988:Ethers, Cyclic / Q000737:chemistry; D015394:Molecular Structure; D011409:Propylene Glycols / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C000595010:6,8-dioxabicyclo(3.2.1)octane; D001688:Biological Products; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004988:Ethers, Cyclic; D011409:Propylene Glycols; C423354:attenol A; C467921:didemniserinolipid B