title: Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, successfully treated by radical cystectomy with adjuvant chemotherapy: a case report.
abstract: BACKGROUND
  Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, is a rare histological type of bladder cancer similar to plasma cells and is an aggressive variant of urothelial carcinoma associated with a poor prognosis.
  
  
  METHODS
  A 41-year-old Asian man was referred to our hospital due to macroscopic hematuria. Cystoscopy detected a non-papillary tumor, and a transurethral resection of the bladder tumor revealed pT1N0M0 bladder cancer. A pathological examination showed high-grade invasive urothelial carcinoma and a component of signet ring cell carcinoma. A follow-up of the transurethral resection with radical cystectomy was carried out, and a pathological examination showed infiltrating urothelial carcinoma, with partial features of the plasmacytoid variant. We added chemotherapy treatment with gemcitabine and cisplatin for two cycles. Our patient has been free from recurrence for 2 years.
  
  
  CONCLUSIONS
  We herein report the case of a patient with a plasmacytoid variant of urothelial carcinoma controlled with radial cystectomy and subsequent chemotherapy.
authors.affiliation: Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. marimo633@yahoo.co.jp.
authors.forename: Mari
authors.initials: M
authors.lastname: Ohtaka
authors.affiliation: Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. takashi_tk2001@yahoo.co.jp.|Department of Urology, Yokohama City University Graduate School of Medicine, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. takashi_tk2001@yahoo.co.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawahara
authors.affiliation: Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. y.kumano.2925@gmail.com.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kumano
authors.affiliation: Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. yocomn_comn@yahoo.co.jp.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Maeda
authors.affiliation: Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. T.Kondo0807@gmail.com.
authors.forename: Takuya
authors.initials: T
authors.lastname: Kondo
authors.affiliation: Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. apotaku24@yahoo.co.jp.
authors.forename: Taku
authors.initials: T
authors.lastname: Mochizuki
authors.affiliation: Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. temp4@kamakura-medical.com.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ishida
authors.affiliation: Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. hatu98@yokohama-cu.ac.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hattori
authors.affiliation: Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. jteran@yokohama-cu.ac.jp.
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Teranishi
authors.affiliation: Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. miyoyasu@yokohama-cu.ac.jp.
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Miyoshi
authors.affiliation: Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. yumura@yokohama-cu.ac.jp.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yumura
authors.affiliation: Department of Urology, Yokohama City University Graduate School of Medicine, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. masayao@yokohama-cu.ac.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yao
authors.affiliation: Department of Diagnostic Pathology, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. inayama@yokohama-cu.ac.jp.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Inayama
authors.affiliation: Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan. hu0428@yokohama-cu.ac.jp.
authors.forename: Hiroji
authors.initials: H
authors.lastname: Uemura
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D015653:Cystectomy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy*; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine