title: First reported cases: renal denervation with second-generation multi-electrode catheter via brachial and radial access.
abstract: Renal denervation is a minimally invasive procedure that aims to reduce brain-kidney sympathetic cross-talk. Despite the negative results of the recent SYMPLICITY HTN-3 trial, the procedure is considered safe and has been associated with many beneficial effects, including the reversal of hypertensive heart disease substrate and the prevention of cardiac arrhythmia. The first-generation radiofrequency catheter system featured a monopolar catheter that required sequential singlepoint energy application, followed by rotation, partial withdrawal of the catheter and re-application of energy. The latest generation device features four electrodes configured in a helical arrangement that can simultaneously ablate in four quadrants of the vessel circumference. Renal denervation via brachial or radial arterial access with the second-generation system has not been described before.
authors.affiliation: Department of Internal Medicine, Stellenbosch University, South Africa ; SA Endovascular, Netcare Kuilsriver Hospital, Cape Town, South Africa.
authors.forename: M J
authors.initials: MJ
authors.lastname: Heradien
authors.affiliation: SA Endovascular, Netcare Kuilsriver Hospital, Cape Town, South Africa.
authors.forename: J
authors.initials: J
authors.lastname: Augustyn
authors.affiliation: SA Endovascular, Netcare Kuilsriver Hospital, Cape Town, South Africa.
authors.forename: A
authors.initials: A
authors.lastname: Saaiman
authors.affiliation: Department of Internal Medicine, Stellenbosch University, South Africa.
authors.forename: P A
authors.initials: PA
authors.lastname: Brink
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D017115:Catheter Ablation / Q000379:methods; D057785:Catheters; D004566:Electrodes; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007668:Kidney / Q000601:surgery*; D008875:Middle Aged; D013562:Sympathectomy / Q000379:methods