title: Influence of Proton and Salt Concentration on the Chromonic Liquid Crystal Phase Diagram of Disodium Cromoglycate Solutions: Prospects and Limitations of a Host for DNA Nanostructures.
abstract: Lyotropic chromonic liquid crystals have recently been suggested for use as a self-organized host for dispersing and aligning self-organized DNA origami nanostructures. However, an appropriate pH value and a suitable cation concentration are necessary to stabilize such nanostructures and to avoid unfolding of the DNA. The present study shows that the nematic and columnar liquid crystal phases appearing in aqueous solutions of disodium cromoglycate are robust against the replacement of deionized water by a neutral or alkaline buffer solution. However, disodium cromoglycate precipitates when an acidic buffer is used or when the concentration of magnesium cations exceeds a critical concentration of about 0.6-0.7 mmol/L.
authors.affiliation: Department of Chemistry, University of Paderborn , Warburger Strasse 100, 33098 Paderborn, Germany.
authors.forename: Bingru
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, University of Paderborn , Warburger Strasse 100, 33098 Paderborn, Germany.
authors.forename: Heinz-S
authors.initials: HS
authors.lastname: Kitzerow
mesh_terms: D004205:Cromolyn Sodium / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D050866:Liquid Crystals / Q000737:chemistry*; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D011522:Protons; D012492:Salts / Q000737:chemistry; D012996:Solutions
chemical_list: D011522:Protons; D012492:Salts; D012996:Solutions; D004247:DNA; D004205:Cromolyn Sodium