title: Neuroimaging-Based Phenotyping of the Autism Spectrum.
abstract: Recent advances in neuroimaging have offered a rich array of structural and functional markers to probe the organization of regional and large-scale brain networks. The current chapter provides a brief introduction into these techniques and overviews their contribution to the understanding of autism spectrum disorder (ASD), a neurodevelopmental condition associated with atypical social cognition, language function, and repetitive behaviors/interests. While it is generally recognized that ASD relates to structural and functional network anomalies, the extent and overall pattern of reported findings have been rather heterogeneous. Indeed, while several attempts have been made to label the main neuroimaging phenotype of ASD (e.g., 'early brain overgrowth hypothesis', 'amygdala theory', 'disconnectivity hypothesis'), none of these frameworks has been without controversy. Methodological sources of inconsistent results may include differences in subject inclusion criteria, variability in image processing, and analysis methodology. However, inconsistencies may also relate to high heterogeneity across the autism spectrum itself. It, therefore, remains to be investigated whether a consistent imaging phenotype that adequately describes the entire autism spectrum can, in fact, be established. On the other hand, as previous findings clearly emphasize the value of neuroimaging in identifying atypical brain morphology, function, and connectivity, they ultimately support its high potential to identify biologically and clinically relevant endophenotypes.
authors.affiliation: Department of Social Neuroscience, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. bernhardt@cbs.mpg.de.|McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada. bernhardt@cbs.mpg.de.
authors.forename: Boris C
authors.initials: BC
authors.lastname: Bernhardt
authors.affiliation: Autism Research Program at the NYU Child Study Center, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Adriana
authors.initials: A
authors.lastname: Di Martino
authors.affiliation: Department of Social Neuroscience, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Sofie L
authors.initials: SL
authors.lastname: Valk
authors.affiliation: Department of Speech and Hearing Sciences, George Washington University, Washington, DC, USA.
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Wallace
mesh_terms: D000067877:Autism Spectrum Disorder / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D006801:Humans; D059906:Neuroimaging / Q000379:methods*; D010641:Phenotype
keywords: ASD; Autism; Biomarkers; Connectome; MRI