title: Chronic hepatitis B associated with hepatic steatosis, insulin resistance, necroinflammation and fibrosis.
abstract: BACKGROUND
  The effect of hepatitis B virus (HBV) infection on fatty liver disease is unclear.
  
  
  OBJECTIVE
  The aim of this study was to investigate the viral and host causes of fatty liver in chronic hepatitis B (CHB) patients. This study included 88 CHB patients of which 17 were not treated. Liver biopsy was performed in each patient. Group 1 included those with hepatic steatosis (n=28) and group 2 those without hepatic steatosis. The groups were compared in terms of age, body mass index (BMI), Homeostasis Model Assessment- Insulin Resistance (HOMA-IR), viral load, biochemical parameters and histological findings. Patients in group 1 were subdivided according to the degree of steatosis as follows: grade 1 (15 patients, 53.6%), grade 2 (6 patients, 21.4%), and grade 3 (7 patients, 25%).
  
  
  RESULTS
  In group 1 (n=28), mean age, BMI, cholesterol, and HOMA-IR were found to be significantly higher than in group 2 (n=60). There were no significant differences in the positivity of viral load, HbeAg, treatment, fibrosis and other laboratory parameters between the two groups. HOMA-IR was the only independent predictive factor of liver steatosis in patients with CHB in logistic regression analysis.
  
  
  CONCLUSIONS
  Hepatic steatosis in CHB patients was associated with host metabolic factors.
authors.affiliation: Department of Internal Medicine, Dicle University School of Medicine, Ankara, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Yilmaz
authors.affiliation: Department of Gastroenterology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Koklu
authors.affiliation: Department of Pathology, Dicle University School of Medicine, Ankara, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Buyukbayram
authors.affiliation: Department of Gastroenterology, Dicle University School of Medicine, Ankara, Turkey.
authors.forename: Kendal
authors.initials: K
authors.lastname: Yalçin
authors.affiliation: Department of Gastroenterology, Bolu Izzet Baysal State Hospital, Bolu, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Korkmaz
authors.affiliation: Department of Gastroenterology, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Posul
authors.affiliation: Department of Gastroenterology, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey.
authors.forename: Guray
authors.initials: G
authors.lastname: Can
authors.affiliation: Department of Gastroenterology, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey.
authors.forename: Mevlut
authors.initials: M
authors.lastname: Kurt
mesh_terms: D000328:Adult; D000410:Alanine Transaminase; D001706:Biopsy; D002784:Cholesterol / Q000097:blood; D005234:Fatty Liver / Q000150:complications / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D005260:Female; D006515:Hepatitis B virus / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000453:epidemiology* / Q000378:metabolism; D019698:Hepatitis C, Chronic / Q000453:epidemiology* / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology* / Q000378:metabolism / Q000821:virology; D015995:Prevalence; D012720:Severity of Illness Index; D019562:Viral Load
chemical_list: D007328:Insulin; D002784:Cholesterol; D000410:Alanine Transaminase
keywords: BMI; Chronic hepatitis B; HOMA-IR; biopsy; liver steatosis