title: Sex-dependent effects of sleep deprivation on myocardial sensitivity to ischemic injury.
abstract: Sleep deprivation is associated with increased risk of myocardial infarction. However, it is unknown whether the effects of sleep deprivation are limited to increasing the likelihood of experiencing a myocardial infarction or if sleep deprivation also increases the extent of myocardial injury. In this study, rats were deprived of paradoxical sleep for 96 h using the platform-over-water method. Control rats were subjected to the same condition except the control platform was large enough for the rats to sleep. Hearts from sleep deprived and control rats were subjected to 20 min ischemia on a Langendorff isolated heart system. Infarct size and post ischemic recovery of contractile function were unaffected by sleep deprivation in male hearts. In contrast, hearts from sleep-deprived females exhibited significantly larger infarcts than hearts from control females. Post ischemic recovery of rate pressure product and + dP/dT were significantly attenuated by sleep deprivation in female hearts, and post ischemic recovery of end diastolic pressure was significantly elevated in hearts from sleep deprived females compared to control females, indicating that post ischemic recovery of both systolic and diastolic function were worsened by sleep deprivation. These data provide evidence that sleep deprivation increases the extent of ischemia-induced injury in a sex-dependent manner.
authors.affiliation: a Department of Psychology , Sociology & Criminal Justice and.
authors.forename: Phillip R
authors.initials: PR
authors.lastname: Zoladz
authors.affiliation: a Department of Psychology , Sociology & Criminal Justice and.
authors.forename: Anna
authors.initials: A
authors.lastname: Krivenko
authors.affiliation: a Department of Psychology , Sociology & Criminal Justice and.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Eisenmann
authors.affiliation: b Department of Pharmaceutical & Biomedical Sciences , Ohio Northern University , Ada , OH , USA.
authors.forename: Albert D
authors.initials: AD
authors.lastname: Bui
authors.affiliation: b Department of Pharmaceutical & Biomedical Sciences , Ohio Northern University , Ada , OH , USA.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Seeley
authors.affiliation: a Department of Psychology , Sociology & Criminal Justice and.
authors.forename: Megan E
authors.initials: ME
authors.lastname: Fry
authors.affiliation: a Department of Psychology , Sociology & Criminal Justice and.
authors.forename: Brandon L
authors.initials: BL
authors.lastname: Johnson
authors.affiliation: b Department of Pharmaceutical & Biomedical Sciences , Ohio Northern University , Ada , OH , USA.
authors.forename: Boyd R
authors.initials: BR
authors.lastname: Rorabaugh
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003971:Diastole; D005260:Female; D006321:Heart / Q000503:physiopathology*; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000502:physiology*; D012737:Sex Factors; D012892:Sleep Deprivation / Q000503:physiopathology*
keywords: Sleep deprivation; cardiac ischemia; heart; heart attack; infarct; ischemic injury