title: Cerebral white matter lesions and silent cerebral infarcts in postmenopausal women with polycystic ovary syndrome.
abstract: OBJECTIVE
  The association between polycystic ovary syndrome (PCOS) and cardiovascular disease remains unclear. Our objective was to examine the relation of PCOS with cerebrovascular disease measured by brain magnetic resonance imaging (MRI) as white matter lesions (WMLs) and silent cerebral infarcts (SCIs).
  
  
  METHODS
  Seventy postmenopausal women with PCOS and 140 controls participated in the case-control, cross-sectional study. Clinical, anthropometric, hormonal and metabolic parameters were measured. WMLs and SCIs were evaluated by brain MRI.
  
  
  RESULTS
  Compared with controls, postmenopausal women with PCOS had higher mean body mass index, larger waist hip ratio, higher level of low-density lipoprotein cholesterol, free androgen index and lower sex hormone-binding globulin level. The PCOS group had a significantly higher prevalence of WMLs (40% versus 22%, p = 0.009), and SCIs (17% versus 7%, p = 0.032) compared to the control group.
  
  
  CONCLUSIONS
  Postmenopausal women with PCOS are associated with WMLs and SCIs.
authors.affiliation: a Department of Geriatric Neurology , Jinling Hospital, Nanjing University School of Medicine , Nanjing , China and.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Guoqing
authors.affiliation: a Department of Geriatric Neurology , Jinling Hospital, Nanjing University School of Medicine , Nanjing , China and.
authors.forename: Sun
authors.initials: S
authors.lastname: Fang
authors.affiliation: a Department of Geriatric Neurology , Jinling Hospital, Nanjing University School of Medicine , Nanjing , China and.
authors.forename: Duan
authors.initials: D
authors.lastname: Lihui
authors.affiliation: a Department of Geriatric Neurology , Jinling Hospital, Nanjing University School of Medicine , Nanjing , China and.
authors.forename: Yan
authors.initials: Y
authors.lastname: Bing
authors.affiliation: a Department of Geriatric Neurology , Jinling Hospital, Nanjing University School of Medicine , Nanjing , China and.
authors.forename: Peng
authors.initials: P
authors.lastname: Qiaoling
authors.affiliation: a Department of Geriatric Neurology , Jinling Hospital, Nanjing University School of Medicine , Nanjing , China and.
authors.forename: Wang
authors.initials: W
authors.lastname: Yingting
authors.affiliation: b Department of Gynecology and Obstetrics , Jinling Hospital, Nanjing University School of Medicine , Nanjing , China.
authors.forename: Liu
authors.initials: L
authors.lastname: Jinxia
mesh_terms: D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000000981:diagnostic imaging* / Q000453:epidemiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000000981:diagnostic imaging* / Q000453:epidemiology; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*; D017698:Postmenopause / Q000097:blood / Q000378:metabolism*
keywords: Polycystic ovary syndrome; silent cerebral infarcts; white matter lesions