title: Neuroinflammation in Synucleinopathies.
abstract: The causes of most neurodegenerative diseases are attributed to multiple genetic and environmental factors interacting with one another. Above all, inflammation in the nervous system has been implicated in many neurodegenerative diseases. Still, the roles of neuroinflammation in disease mechanisms and the triggers of inflammatory responses in disease-inflicted brain tissues seem to remain unclear. This review will examine previous studies that had been done from genetic, pathological and epidemiological perspectives. These studies assess the involvement of neuroinflammation in synucleinopathies, a group of neurodegenerative diseases that are characterized by deposition of α-synuclein aggregates such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. The review will also discuss the role of α-synuclein aggregates in triggering inflammatory responses from glial cells. It is expected that a precise assessment of the roles and mechanisms of neuroinflammation in neurodegenerative diseases will pave the way for the development of disease-modifying drugs.
authors.affiliation: Department of Biomedical Sciences, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, 03080, Korea.
authors.forename: Somin
authors.initials: S
authors.lastname: Lim
authors.affiliation: Department of Biomedical Sciences, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, 03080, Korea.
authors.forename: Yewon
authors.initials: Y
authors.lastname: Chun
authors.affiliation: Department of Biomedical Sciences, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, 03080, Korea.
authors.forename: Jun Sung
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Biomedical Sciences, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, 03080, Korea.
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000209:etiology* / Q000473:pathology*; D051843:Synucleins / Q000009:adverse effects*
chemical_list: D051843:Synucleins
keywords: Parkinson's disease; eurodegeneration; inflammation; microglia; synuclein