title: Ocular blood flow and cerebrospinal fluid pressure in glaucoma.
abstract: Disease mechanism underlying glaucoma remains unclear. Extensive research on this pathology has highlighted changes in vascular parameters and in circulation of the cerebrospinal fluid (CSF). Here, we review the most recent research on alterations in ocular blood flow and/or CSF flow in glaucoma. Ultrasound Doppler imaging studies have shown an increased resistive index in ophthalmic artery's in glaucoma. Furthermore, changes in optic nerve CSF circulation, which can be assessed with magnetic resonance imaging, may lead to a greater translaminar pressure difference, mechanical stress, and poor clearance of toxic substances. This constitutes a new approach for understanding blood-CSF interactions involved in glaucoma.
authors.affiliation: Ophthalmology Department, Amiens University Medical Center, Amiens, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Promelle
authors.affiliation: Bioflow Image Unit, Jules Verne University of Picardie, Amiens, France.
authors.forename: Joël
authors.initials: J
authors.lastname: Daouk
authors.affiliation: Bioflow Image Unit, Jules Verne University of Picardie, Amiens, France; Medical Image Processing Unit, Amiens University Medical Center, Amiens, France.
authors.forename: Roger
authors.initials: R
authors.lastname: Bouzerar
authors.affiliation: Ophthalmology Department, Amiens University Medical Center, Amiens, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Jany
authors.affiliation: Ophthalmology Department, Amiens University Medical Center, Amiens, France.
authors.forename: Solange
authors.initials: S
authors.lastname: Milazzo
authors.affiliation: Bioflow Image Unit, Jules Verne University of Picardie, Amiens, France; Medical Image Processing Unit, Amiens University Medical Center, Amiens, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Balédent
keywords: Glaucoma; blood flow; cerebrospinal fluid (CSF); regulation