title: For avid glucose tumors, the SUV peak is the most reliable parameter for [(18)F]FDG-PET/CT quantification, regardless of acquisition time.
abstract: BACKGROUND
  This study is an assessment of the impact of acquisition times on SUV with [(18)F]FDG-PET/CT on healthy livers (reference organ with stable uptake over time) and on tumors.
  
  
  METHODS
  One hundred six [(18)F]FDG-PET/CT were acquired in list mode over a single-bed position (livers (n = 48) or on tumors (n = 58)). Six independent datasets of different durations were reconstructed (from 1.5 to 10 min). SUVmax (hottest voxel), SUVpeak (maximum average SUV within a 1-cm(3) spherical volume), and SUVaverage were measured within a 3-cm-diameter volume of interest (VOI) in the right lobe of the liver. For [(18)F]FDG avid tumors (SUVmax ≥ 5), the SUVmax, SUVpeak, and SUV41% (isocontour threshold method) were computed.
  
  
  RESULTS
  For tumors, SUVpeak values did not vary with acquisition time. SUVmax displayed significant differences between 1.5- and 5-10-min reconstruction times. SUV41% was the most time-dependent parameter. For the liver, the SUVaverage was the sole parameter that did not vary over time.
  
  
  CONCLUSIONS
  For [(18)F]FDG avid tumors, with short acquisition times, i.e., with new generations of PET systems, the SUVpeak may be more robust than the SUVmax. The SUVaverage over a 3-cm-diameter VOI in the right lobe of the liver appears to be a good method for a robust and reproducible assessment of the hepatic metabolism.
authors.affiliation: Nuclear Medicine Department, University Hospital - Angers, 4 rue Larrey 49933, Angers, Cedex 09, France. av.sher@yahoo.com.
authors.forename: Avigaëlle
authors.initials: A
authors.lastname: Sher
authors.affiliation: Nuclear Medicine Department, University Hospital - Angers, 4 rue Larrey 49933, Angers, Cedex 09, France.|LUNAM Université - INSERM UMR-S 1066, Micro et nanomédecine biomimétiques, 4 rue Larrey 49933, Angers, Cedex 09, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Lacoeuille
authors.affiliation: Nuclear Medicine Department, University Hospital - Angers, 4 rue Larrey 49933, Angers, Cedex 09, France.
authors.forename: Pacôme
authors.initials: P
authors.lastname: Fosse
authors.affiliation: Nuclear Medicine Department, University Hospital - Angers, 4 rue Larrey 49933, Angers, Cedex 09, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Vervueren
authors.forename: Aurélie
authors.initials: A
authors.lastname: Cahouet-Vannier
authors.affiliation: Nuclear Medicine Department, University Hospital - Angers, 4 rue Larrey 49933, Angers, Cedex 09, France.
authors.forename: Djamel
authors.initials: D
authors.lastname: Dabli
authors.affiliation: Nuclear Medicine Department, University Hospital - Angers, 4 rue Larrey 49933, Angers, Cedex 09, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Bouchet
authors.affiliation: Nuclear Medicine Department, University Hospital - Angers, 4 rue Larrey 49933, Angers, Cedex 09, France.|LUNAM Université - INSERM UMR-S 1066, Micro et nanomédecine biomimétiques, 4 rue Larrey 49933, Angers, Cedex 09, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Couturier
keywords: Acquisition time; SUVpeak; [18F]FDG uptake