title: Low Prevalence of Sleep Disorders in Demyelinating Disease in a Northern Tenerife Population.
abstract: Sleep disorders are seen in patients with demyelinating disease (DD) more often than in the general population. Combination of physical and psychological factors such as pain, spasms, nocturia, depression, anxiety, or medication effects could contribute to sleep disruption. Frequently, these disturbances have a major impact on health and quality of life of patients. The aim of this study was to estimate the prevalence of sleep disorders in patients seen in the DD consultation.
  
  
  
  240 patients; mean age 43 years, 187 women; 163 patients with multiple sclerosis (MS): 144 relapsing-remitting, 19 progressive forms, 36 clinically isolated syndrome, 26 radiological isolated syndrome, and 15 patients with others DD. All participants completed questionnaires: Pittsburgh, Epworth, and Stanford scales, indirect symptoms of RLS and Obstructive Sleep Apnea, Fatigue Severity Scale, and Multiple Sclerosis Quality of Life-54.
  
  
  
  Moderate/severe insomnia 12.5%, OSA 5.8%, RLS 9.6% (confirmed 3 cases), narcolepsy 0, fatigue (> 4) 24.6%. Physical QoL 66.6 ± 19.6, Mental QoL 66.1 ± 21.9. Patients with an established diagnosis showed higher scores on insomnia compared to the group of CIS and RIS (F = 3.85; p = 0.023), no differences were in the other parameters. Fatigue showed high correlation with insomnia (r = 0.443; p < 0.001), RLS (r = 0.513; p < 0.001), and sleepiness (r = 0.211; p = 0.001). None of the variables included in the regression model were shown to be predictors of Physical and Mental QoL.
  
  
  
  A high percentage of our sample sleeps well. Emphasize the low prevalence of sleep disorders (insomnia, fatigue, RLS, etc). We detected an overestimation in the RLS questionnaire and the low QoL recorded.
authors.affiliation: Department of Neurology, Hospital Universitario de Canarias, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: González-Platas
authors.affiliation: Faculty of Mathematics and Physics, University of La Laguna, Campus Anchieta, La Laguna, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: González-Platas
authors.affiliation: Department of Neurology, Hospital Universitario de Canarias, Spain.
authors.forename: Moises
authors.initials: M
authors.lastname: Bermúdez-Hernández
authors.affiliation: Department of Neurology, Hospital Universitario de Canarias, Spain.
authors.forename: Maria Yaiza
authors.initials: MY
authors.lastname: Pérez-Martín
authors.affiliation: Department of Neurology, Hospital Universitario de Canarias, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Croissier-Elías
authors.affiliation: Department of Neurology, Hospital Universitario de Canarias, Spain.
authors.forename: Pedro Javier
authors.initials: PJ
authors.lastname: Pérez-Lorensu
mesh_terms: D000328:Adult; D015897:Comorbidity; D020278:Demyelinating Autoimmune Diseases, CNS / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography; D015995:Prevalence; D012893:Sleep Wake Disorders / Q000453:epidemiology*; D013030:Spain / Q000453:epidemiology
keywords: demyelinating disease; fatigue; multiple sclerosis; sleep disorders