title: Does tight control of systemic factors help in the management of diabetic retinopathy?
abstract: Diabetic retinopathy (DR), one of the leading causes of preventable blindness, is associated with many systemic factors that contribute to the development and progression of this microvascular complication of diabetes. While the duration of diabetes is the major risk factor for the development of DR, the main modifiable systemic risk factors for development and progression of DR are hyperglycemia, hypertension, and dyslipidemia. This review article looks at the evidence that control of these systemic factors has significant benefits in delaying the onset and progression of DR.
authors.forename: Ramachandran
authors.initials: R
authors.lastname: Rajalakshmi
authors.forename: Vijayaraghavan
authors.initials: V
authors.lastname: Prathiba
authors.affiliation: Department of Diabetology, Dr. Mohan's Diabetes Specialties Centre and Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India.
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Mohan
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D003920:Diabetes Mellitus / Q000378:metabolism / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000378:metabolism / Q000503:physiopathology*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D038321:Glycemic Index; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D012084:Renin-Angiotensin System / Q000502:physiology; D012307:Risk Factors; D000068900:Sitagliptin Phosphate / Q000627:therapeutic use; D045162:Thiazolidinediones / Q000627:therapeutic use; D014786:Vision Disorders / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D000068900:Sitagliptin Phosphate; D045162:Thiazolidinediones; C517652:hemoglobin A1c protein, human