title: Rhodium-catalyzed pyridannulation of indoles with diazoenals: a direct approach to pyrido[1,2-a]indoles.
abstract: A novel rhodium catalyzed pyridannulation of 3-substituted indoles with diazoenals furnished privileged pyrido[1,2-a]indoles. The reaction is proposed to involve a [4 + 2]-annulation of the diacceptor rhodium enalcarbenoid via C-2 functionalization of the indole. The utility of the methodology was demonstrated with a short synthesis of the tetrahydropyrido[1,2-a]indole core, present in a large number of biologically important polycyclic indole alkaloids.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education & Research, Bhopal, Madhya Pradesh 462066, India. sk@iiserb.ac.in.
authors.forename: Sudam Ganpat
authors.initials: SG
authors.lastname: Dawande
authors.forename: Bapurao Sudam
authors.initials: BS
authors.lastname: Lad
authors.forename: Sunitkumar
authors.initials: S
authors.lastname: Prajapati
authors.forename: Sreenivas
authors.initials: S
authors.lastname: Katukojvala