title: Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution: application in protein labelling.
abstract: The photo-induced reactions of diaryltetrazoles with carboxylic acids in aqueous solution were investigated. Besides measuring the apparent second-order rate constant and evaluating the functional group compatibility of these reactions, we further incorporated the tetrazoles into SAHA, leading to a new active-site-directed probe for labelling HDACs in both cell lysates and living cells.
authors.affiliation: Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. tuopingluo@pku.edu.cn and Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry and Molecular Engineering, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. tuopingluo@pku.edu.cn and Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry and Molecular Engineering, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Jianye
authors.initials: J
authors.lastname: Dai
authors.affiliation: Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry and Molecular Engineering, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Mo
authors.initials: M
authors.lastname: Hu
authors.affiliation: Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry and Molecular Engineering, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.affiliation: Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry and Molecular Engineering, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Meng
authors.affiliation: Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry and Molecular Engineering, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Liu
authors.affiliation: Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. tuopingluo@pku.edu.cn and Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry and Molecular Engineering, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Chu
authors.initials: C
authors.lastname: Wang
authors.affiliation: Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. tuopingluo@pku.edu.cn and Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry and Molecular Engineering, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Tuoping
authors.initials: T
authors.lastname: Luo
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D008027:Light; D008954:Models, Biological; D015394:Molecular Structure; D009211:Myoglobin / Q000737:chemistry; D019920:Photoaffinity Labels; D010777:Photochemistry; D011422:Propionates / Q000737:chemistry; D012996:Solutions / Q000737:chemistry; D013777:Tetrazoles / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D009211:Myoglobin; D019920:Photoaffinity Labels; D011422:Propionates; D012996:Solutions; D013777:Tetrazoles; D014867:Water; C029658:propionic acid