title: Application of Nanotechnology in the Diagnosis and Therapy of Hepatocellular Carcinoma.
abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. However, the inherent limitations of traditional surgery and insensitivity to radiation and chemotherapy result in failing treatment and poor prognosis. In recent years, the development and advances of nanotechnology has brought new hope for the diagnosis and treatment of HCC. This article reviews the development of nanoparticles used for cancer detection, diagnosis and treatment due to their large specific surface area and unique optical, electronic and magnetic properties. Moreover, studies have shown that after intended surface modification, nano-carriers can achieve active targeting effect, which improves the efficiency of chemotherapeutic drugs and decreases their side effects. In this review, we provide an overview of these studies results, patents about novel nanomaterials and conclude with a discussion about future development.
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Hou
authors.affiliation: Dermatology Department, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, Jiangsu P.R. China. dr.guanjiang@gmail.com.
authors.forename: Guan
authors.initials: G
authors.lastname: Jiang
authors.forename: Chun-Sheng
authors.initials: CS
authors.lastname: Yang
authors.forename: Jian-Qin
authors.initials: JQ
authors.lastname: Tang
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Wei
authors.affiliation: . xyfylyq@sohu.com.
authors.forename: Yan-Qun
authors.initials: YQ
authors.lastname: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D003287:Contrast Media; D004059:Diffusion of Innovation; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D025202:Molecular Diagnostic Techniques; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles; D011237:Predictive Value of Tests; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D004337:Drug Carriers