title: [Structural and Functional Modifications of Human Lymphocytes in Dynamics of UV-Induced Development of Their Apoptosis].
abstract: The flow-cytometric analysis of condition of human peripheral blood lymphocytes in dynamics of development of the apoptosis induced by exposure to UV-light (240-390 nanometers) at a dose of 1510 J/m2 was carried out. Superficial architectonics and changes of the level of a membrane potential and functional activity of succinatedehydrogenase of mitochondrions are studied. The contribution of extracellular calcium to the processes of lymphocyte cellular death is revealed. The ideas about dynamics of the intracellular events leading to the death of photomodified lymphocytes 1-6 h after their UV-radiation exposure are specified and added on the basis of the analysis of our new and already published results.
authors.forename: M A
authors.initials: MA
authors.lastname: Nakvasina
authors.forename: O V
authors.initials: OV
authors.lastname: Lidokhova
authors.forename: T L
authors.initials: TL
authors.lastname: Domanskya
authors.forename: V G
authors.initials: VG
authors.lastname: Artyukhov
authors.forename: S V
authors.initials: SV
authors.lastname: Ryazantsev
mesh_terms: D017209:Apoptosis / Q000528:radiation effects*; D002118:Calcium / Q000378:metabolism; D018929:Cell Culture Techniques; D002478:Cells, Cultured; D003470:Culture Media / Q000737:chemistry; D053938:DNA Fragmentation / Q000528:radiation effects*; D004305:Dose-Response Relationship, Drug; D005434:Flow Cytometry; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects* / Q000648:ultrastructure; D008928:Mitochondria / Q000201:enzymology / Q000528:radiation effects / Q000648:ultrastructure; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D003470:Culture Media; D013385:Succinate Dehydrogenase; D002118:Calcium