title: Follow-Up of Children with Gastrointestinal Malformations and Postnatal Surgery and Anesthesia: Evaluation at Two Years of Age.
abstract: The impact of general anesthesia is considered a risk factor for developmental delay. Very few studies have been performed to measure the neurodevelopmental outcome of patients with selected malformations.
  
  
  
  The purpose of this ambidirectional cohort study was to measure the neurodevelopmental outcome of patients with congenital gastrointestinal-tract malformations (GIM).
  
  
  
  Forty patients with relevant congenital GIM born in the period from June 2008 to April 2011 were identified. The inclusion criteria were a gestational age >32 completed weeks and surgery that required a general anesthetic within the first 28 days of life. The neonatal characteristics and anesthesia data were retrospectively collected. Based on information about the neonatal characteristics and socioeconomic background, a matched pair was found. All participants were tested at the corrected age of 24 months with the Bayley Scales of Infant Development II assessment.
  
  
  
  The outcome was split into the psychomotor index (PDI) and mental developmental index (MDI). The patient group achieved a mean PDI of 103 and the control group achieved 106, i.e. these values were not significantly different. The mean MDI was 102 in the patient group and 110 in the control group. This difference was significant (p = 0.022). Detailed analysis of the items showed no significance for nonverbal items but a significant difference for verbal items (p = 0.029). Further analysis showed no correlation between relevant anesthesia data and the neurodevelopmental outcome.
  
  
  
  We found lower MDI scores due to worse verbal abilities in the patient group. Children born with GIM should be considered a risk group with respect to language development.
authors.affiliation: Department of Neonatology, J.W. Goethe University Hospital, Frankfurt am Main, Germany.
authors.forename: Nora
authors.initials: N
authors.lastname: Doberschuetz
authors.forename: Ruth
authors.initials: R
authors.lastname: Dewitz
authors.forename: Udo
authors.initials: U
authors.lastname: Rolle
authors.forename: Rolf
authors.initials: R
authors.lastname: Schlösser
authors.forename: Antje
authors.initials: A
authors.lastname: Allendorf
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects / Q000379:methods*; D016022:Case-Control Studies; D002675:Child, Preschool; D000013:Congenital Abnormalities / Q000601:surgery*; D003430:Cross-Sectional Studies; D016208:Databases, Factual; D004065:Digestive System Abnormalities / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D007223:Infant; D007804:Language Development; D008297:Male; D011597:Psychomotor Performance; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index