title: A case of adenoid cystic carcinoma of the esophagus.
abstract: Esophageal adenoid cystic carcinoma (EACC) is a very rare form of malignant tumor in the esophagus. Here, we report the case of a 78-year-old man who was diagnosed with EACC by preoperative endoscopic biopsy. Thoracoscopy-assisted subtotal esophagectomy with lymph node dissection was carried out. Microscopic examination of the resected specimen suggested that the tumor invaded to submucosal layer and showed no lymph node metastasis. Histologically, tumor primarily exhibited an alveolar solid pattern with partial cribriform and tubular patterns. Alcian blue staining showed many mucoid materials within the glandular cavity formed by tumor cells. Immunohistochemical studies revealed that the tumor cells reacted with pan-cytokeratin immunostains and expressed vimentin and S-100 protein. Collectively, the tumor was diagnosed as primary EACC, T1bN0M0 according to "Japanese Classification of Esophageal Cancer 10th edition." The patient showed no recurrence sign 12 months after the surgery.The current study also reviewed 35 EACC cases reported in Japanese literatures from 1990 to 2014. Combined with our case, we found that EACC is less frequently accompanied by lymph node metastasis as compared to esophageal squamous cell carcinoma, especially at the early stage. The prognosis of EACC is relatively better when tumors have no lymph node metastasis.
authors.affiliation: Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyamacho, Kure, 737-0023, Japan. gsawada@gesurg.med.osaka-u.ac.jp.
authors.forename: Genta
authors.initials: G
authors.lastname: Sawada
authors.affiliation: Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyamacho, Kure, 737-0023, Japan. mun_c@hotmail.co.jp.
authors.forename: Jeongho
authors.initials: J
authors.lastname: Moon
authors.affiliation: Department of Diagnostic Pathology, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, Kure, Japan. saitoa@kure-nh.go.jp.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Saito
authors.affiliation: Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyamacho, Kure, 737-0023, Japan. kzkoda.no.9@gmail.com.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Odagiri
authors.affiliation: Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyamacho, Kure, 737-0023, Japan. yurikitty9981@yahoo.co.jp.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyamacho, Kure, 737-0023, Japan. nos_boost_bz_gen0514@yahoo.co.jp.
authors.forename: Gen
authors.initials: G
authors.lastname: Takahashi
authors.affiliation: Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyamacho, Kure, 737-0023, Japan. osakansa@yahoo.co.jp.
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamashita
authors.affiliation: Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyamacho, Kure, 737-0023, Japan. inouem@kure-nh.go.jp.
authors.forename: Masashi
authors.initials: M
authors.lastname: Inoue
authors.affiliation: Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyamacho, Kure, 737-0023, Japan. ireit@kure-nh.go.jp.
authors.forename: Toshimitu
authors.initials: T
authors.lastname: Irei
authors.affiliation: Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyamacho, Kure, 737-0023, Japan. nakahira@sakai-hospital.jp.
authors.forename: Shin
authors.initials: S
authors.lastname: Nakahira
authors.affiliation: Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyamacho, Kure, 737-0023, Japan. yosukes@kure-nh.go.jp.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Shimizu
authors.affiliation: Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyamacho, Kure, 737-0023, Japan. haltomi@me.com.
authors.forename: Harumi
authors.initials: H
authors.lastname: Tominaga
authors.affiliation: Department of Diagnostic Pathology, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, Kure, Japan. kuraokak@kure-nh.go.jp.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Kuraoka
authors.affiliation: National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, Kure, Japan. taniyamak@kure-nh.go.jp.
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Taniyama
authors.affiliation: Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyamacho, Kure, 737-0023, Japan. hatanakan0829@yahoo.co.jp.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hatanaka
keywords: Adenoid cystic carcinoma; Esophageal cancer