title: Whole Body Vibration Improves Insulin Resistance in db/db Mice: Amelioration of Lipid Accumulation and Oxidative Stress.
abstract: Insulin resistance (IR) is the hallmark of type 2 diabetes mellitus (T2DM), which is one of the most important chronic noncommunicable diseases. Effective and feasible strategies to treat IR are still urgently needed. Previous research studies reported that whole body vibration (WBV) was beneficial for IR in clinical; however, its underlying mechanisms remains unknown. In the present study, db/db mice were treated with WBV administration 60 min/day for 12 weeks and the impaired insulin sensitivity was improved. Besides, liver steatosis was also ameliorated. Further explorations revealed that WBV could reduce the expression of SREBP1c and increase the expression of GSH-Px and consequently suppress oxidative stress. In conclusion, WBV attenuates oxidative stress to ameliorate liver steatosis and thus improves insulin resistance in db/db mice. Therefore, WBV administration is a promising treatment for individuals who suffered from central obesity and IR.
authors.affiliation: Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free Radical Biology and Medicine, School of Public Health, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, The Fourth Military Medical University, Xi'an, 710032, People's Republic of China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Zhai
authors.affiliation: Department of Radiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, People's Republic of China.
authors.forename: Fan
authors.initials: F
authors.lastname: Guo
authors.affiliation: Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free Radical Biology and Medicine, School of Public Health, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.
authors.forename: Tengrui
authors.initials: T
authors.lastname: Shi
authors.affiliation: Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free Radical Biology and Medicine, School of Public Health, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.
authors.forename: Jiangzheng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free Radical Biology and Medicine, School of Public Health, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free Radical Biology and Medicine, School of Public Health, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.
authors.forename: Xiaodi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Biomedical Engineering, The Fourth Military Medical University, Xi'an, 710032, People's Republic of China. jingdaasq@126.com.
authors.forename: Da
authors.initials: D
authors.lastname: Jing
authors.affiliation: Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free Radical Biology and Medicine, School of Public Health, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China. cx-hai@fmmu.edu.cn.
authors.forename: Chunxu
authors.initials: C
authors.lastname: Hai
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000235:genetics*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D016688:Mice, Inbred NOD; D018384:Oxidative Stress / Q000502:physiology*; D013314:Stress, Mechanical; D014732:Vibration
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: Glutathione peroxidases; Insulin resistance; Liver steatosis; Oxidative stress; Whole body vibration