title: Central serous chorioretinopathy: from glucocorticoids to light intensity.
abstract: Central serous chorioretinopathy (CSC) is characterized by a localized accumulation of subretinal fluid and an idiopathic focal leakage from choroidal vessels. The exact pathogenesis of CSC, however, still remains obscure. In this paper, we hypothesized that CSC may result from a response of choroidal vessels to an acute increase in the environmental light intensity leading to a focal leakage from the choroidal vessels. High levels of glucocorticoids, in our proposed model, may cause persistence rather than initiation of the focal leakage, probably by suppressing the synthesis of collagen and extracellular matrix components and inhibiting fibroblastic activity.
authors.affiliation: Eye Research Center, Khatam-Al-Anbia Eye Hospital, Mashhad University of Medical Sciences, Mashhad 91959-65919, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Norouzpour
authors.affiliation: Retina Research Center, Khatam-Al-Anbia Eye Hospital, Mashhad University of Medical Sciences, Mashhad 91959-65919, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Abrishami
keywords: central serous chorioretinopathy; choroidal vessels; glucocorticoids; light intensity; temperature