title: Suvorexant: a promising, novel treatment for insomnia.
abstract: Suvorexant a novel, orexin receptor antagonist was recently approved by the US Food and Drug Administration for the treatment of sleep onset and sleep maintenance insomnia in August 2014. Multiple animal and human studies support the efficacy, safety, and tolerability of suvorexant for patients of various profiles. Current recommendations advocate for a starting dose of 10 mg and a maximum dose of 20 mg, with cautious use in women, obese patients, and patients taking other CYP3A4 inhibitors. More head-to-head studies comparing suvorexant to other sedative-hypnotic therapies are needed to further delineate which patients will benefit the most from this medication over others.
authors.affiliation: Division of Neurology, Sleep Disorders Center, Banner University Medical Center, Phoenix, AZ, USA.
authors.forename: Joyce K
authors.initials: JK
authors.lastname: Lee-Iannotti
authors.affiliation: Division of Pulmonary Medicine, Center for Sleep Medicine, Mayo Clinic, Phoenix, AZ, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Parish
keywords: CYP3A4; MK-4305; benzodiazepan receptor antagonist; insomnia; orexin-receptor antagonist