title: The mycotoxin definition reconsidered towards fungal cyclic depsipeptides.
abstract: Currently, next to the major classes, cyclic depsipeptides beauvericin and enniatins are also positioned as mycotoxins. However, as there are hundreds more fungal cyclic depsipeptides already identified, should these not be considered as mycotoxins as well? The current status of the mycotoxin definition revealed a lack of consistency, leading to confusion about what compounds should be called mycotoxins. Because this is of pivotal importance in risk assessment prioritization, a clear and quantitatively expressed mycotoxin definition is proposed, based on data of widely accepted mycotoxins. Finally, this definition is applied to a set of fungal cyclic depsipeptides, revealing that some of these should indeed be considered as mycotoxins.
authors.affiliation: a Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University , Ghent , Belgium.
authors.forename: Lien
authors.initials: L
authors.lastname: Taevernier
authors.affiliation: a Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University , Ghent , Belgium.
authors.forename: Evelien
authors.initials: E
authors.lastname: Wynendaele
authors.affiliation: b Centre for Logic and Philosophy of Science, Faculty of Arts and Philosophy, Ghent University , Ghent , Belgium.
authors.forename: Leen
authors.initials: L
authors.lastname: De Vreese
authors.affiliation: c Department of Comparative Physiology and Biometrics , Faculty of Veterinary Medicine, Ghent University , Merelbeke , Belgium.
authors.forename: Christian
authors.initials: C
authors.lastname: Burvenich
authors.affiliation: a Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University , Ghent , Belgium.
authors.forename: Bart
authors.initials: B
authors.lastname: De Spiegeleer
mesh_terms: D047630:Depsipeptides / Q000145:classification / Q000633:toxicity; D005658:Fungi; D009183:Mycotoxins / Q000145:classification / Q000633:toxicity*
chemical_list: D047630:Depsipeptides; D009183:Mycotoxins; C100264:enniatins; C004456:beauvericin
keywords: Cyclic depsipeptides; definition; hazard; mycotoxins; risk; toxicity