title: Complement factor H and susceptibility to major depressive disorder in Han Chinese.
abstract: Accumulating evidence suggests that altered immunity contributes to the development of major depressive disorder (MDD).
  
  
  
  To examine whether complement factor H (CFH), a regulator of activation of the alternative pathway of the complement cascade, confers susceptibility to MDD.
  
  
  
  Expression analyses were tested in 53 unmedicated people with MDD and 55 healthy controls. A two-stage genetic association analysis was performed in 3323 Han Chinese with or without MDD. Potential associations between CFH single nucleotide polymorphisms and age at MDD onset were evaluated.
  
  
  
  CFH levels were significantly lower in the MDD group at both protein and mRNA levels (P = 0.009 and P = 0.014 respectively). A regulatory variant in the CFH gene, rs1061170, showed statistically significant genotypic and allelic differences between the MDD and control groups (genotypic P = 0.0005, allelic P = 0.0001). Kaplan-Meier survival analysis showed that age at onset of MDD was significantly associated with the C allele of rs1061170 (log rank statistic χ(2) = 6.82, P = 0.009). The C-allele carriers had a younger age at onset of MDD (22.2 years, s.d. = 4.0) than those without the C allele (23.6 years, s.d. = 4.3).
  
  
  
  CFH is likely to play an important role in the development of MDD. rs1061170 has an important effect on age at onset of MDD in Han Chinese and may therefore be related to early pathogenesis of MDD, although further study is needed.
authors.affiliation: Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Deng-Feng Zhang, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Zhi-Guo Wu, MD, PhD, Dai-Hui Peng, MD, PhD, Jun Chen, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; Jianliang Ni, MD, Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang; Wenxin Tang, MD, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang; Lin Xu, PhD, Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan and CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai; Yi-Ru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Deng-Feng Zhang, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Zhi-Guo Wu, MD, PhD, Dai-Hui Peng, MD, PhD, Jun Chen, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; Jianliang Ni, MD, Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang; Wenxin Tang, MD, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang; Lin Xu, PhD, Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan and CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai; Yi-Ru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Deng-Feng
authors.initials: DF
authors.lastname: Zhang
authors.affiliation: Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Deng-Feng Zhang, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Zhi-Guo Wu, MD, PhD, Dai-Hui Peng, MD, PhD, Jun Chen, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; Jianliang Ni, MD, Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang; Wenxin Tang, MD, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang; Lin Xu, PhD, Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan and CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai; Yi-Ru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Zhi-Guo
authors.initials: ZG
authors.lastname: Wu
authors.affiliation: Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Deng-Feng Zhang, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Zhi-Guo Wu, MD, PhD, Dai-Hui Peng, MD, PhD, Jun Chen, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; Jianliang Ni, MD, Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang; Wenxin Tang, MD, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang; Lin Xu, PhD, Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan and CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai; Yi-Ru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Dai-Hui
authors.initials: DH
authors.lastname: Peng
authors.affiliation: Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Deng-Feng Zhang, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Zhi-Guo Wu, MD, PhD, Dai-Hui Peng, MD, PhD, Jun Chen, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; Jianliang Ni, MD, Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang; Wenxin Tang, MD, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang; Lin Xu, PhD, Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan and CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai; Yi-Ru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Deng-Feng Zhang, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Zhi-Guo Wu, MD, PhD, Dai-Hui Peng, MD, PhD, Jun Chen, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; Jianliang Ni, MD, Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang; Wenxin Tang, MD, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang; Lin Xu, PhD, Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan and CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai; Yi-Ru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Jianliang
authors.initials: J
authors.lastname: Ni
authors.affiliation: Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Deng-Feng Zhang, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Zhi-Guo Wu, MD, PhD, Dai-Hui Peng, MD, PhD, Jun Chen, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; Jianliang Ni, MD, Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang; Wenxin Tang, MD, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang; Lin Xu, PhD, Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan and CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai; Yi-Ru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Tang
authors.affiliation: Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Deng-Feng Zhang, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Zhi-Guo Wu, MD, PhD, Dai-Hui Peng, MD, PhD, Jun Chen, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; Jianliang Ni, MD, Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang; Wenxin Tang, MD, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang; Lin Xu, PhD, Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan and CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai; Yi-Ru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Deng-Feng Zhang, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Zhi-Guo Wu, MD, PhD, Dai-Hui Peng, MD, PhD, Jun Chen, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; Jianliang Ni, MD, Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang; Wenxin Tang, MD, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang; Lin Xu, PhD, Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan and CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai; Yi-Ru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China yirufang@aliyun.com yaoyg@mail.kiz.ac.cn.
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Yao
authors.affiliation: Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Deng-Feng Zhang, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan; Zhi-Guo Wu, MD, PhD, Dai-Hui Peng, MD, PhD, Jun Chen, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; Jianliang Ni, MD, Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang; Wenxin Tang, MD, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang; Lin Xu, PhD, Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan and CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai; Yi-Ru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China yirufang@aliyun.com yaoyg@mail.kiz.ac.cn.
authors.forename: Yi-Ru
authors.initials: YR
authors.lastname: Fang
mesh_terms: D000328:Adult; D017668:Age of Onset; D002681:China; D017242:Complement Factor H / Q000235:genetics; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: C493495:CFH protein, human; D017242:Complement Factor H