title: Reviving virus based cancer vaccines by using cytomegalovirus vectors expressing modified tumor antigens.
abstract: Cancer vaccines that have utilized various immunization strategies to induce antitumor immunity have largely failed in clinical settings. We have recently developed a cancer vaccine using a cytomegalovirus (CMV) based vector that expressed a modified melanoma antigen that elicited a robust antitumor CD8+T cell response and tumor rejection.
authors.affiliation: Department of Immunology.
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Qiu
authors.affiliation: Department of Immunology.
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Grenier
authors.affiliation: Department of Immunology; Department of Pediatrics; University of Connecticut Health Center; Farmington, CT USA.
authors.forename: Kamal M
authors.initials: KM
authors.lastname: Khanna
keywords: cancer vaccines; immunotherapy; melanoma; viral vectors