title: The Levels of Cortisol, Oxidative Stress, and DNA Damage in the Victims of Childhood Sexual Abuse: A Preliminary Study.
abstract: In this study we aimed to investigate serum cortisol, oxidative stress, and DNA damage in children who are sexual abuse victims. The study included 38 children who sustained child sexual abuse and 38 age- and gender-matched children who did not have a history of trauma. Cortisol levels reflecting the status of the hypothalamic-pituitary-adrenal axis, anti-oxidant enzymes glutathione peroxidase, superoxide dismutase, natural anti-oxidant coenzyme Q, and 8-hydroxy-2-deoxyguanosine as the indicator of DNA damage were analyzed in serum samples using the enzyme linked immunosorbent assay method. Cortisol levels were significantly higher in the child sexual abuse group compared to the control group. There were no significant differences between the groups in terms of oxidative stress and DNA damage. Cortisol and 8-hydroxy-2-deoxyguanosine levels decreased as the time elapsed since the sexual abuse increased. Coenzyme Q level was lower in victims who sustained multiple assaults than in the victims of a single assault. Cortisol and superoxide dismutase levels were lower in the victims of familial sexual abuse. Decreases in cortisol and 8-hydroxy-2-deoxyguanosine levels as time elapsed may be an adaptation to the toxic effects of high cortisol levels over a prolonged period of time. Child sexual abuse did not result in oxidative stress and DNA damage; however, some features of sexual abuse raised the level of oxidative stress.
authors.affiliation: a Department of Child Psychiatry, Dicle University , Diyarbakır , Turkey.
authors.forename: Şeref
authors.initials: Ş
authors.lastname: Şimşek
authors.affiliation: b Department of Biochemistry, Dicle University , Diyarbakır , Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Kaplan
authors.affiliation: c Department of Forensic Medicine, Dicle University , Diyarbakır , Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Uysal
authors.affiliation: a Department of Child Psychiatry, Dicle University , Diyarbakır , Turkey.
authors.forename: Tuğba
authors.initials: T
authors.lastname: Yüksel
authors.affiliation: a Department of Child Psychiatry, Dicle University , Diyarbakır , Turkey.
authors.forename: Rümeysa
authors.initials: R
authors.lastname: Alaca
mesh_terms: D000293:Adolescent; D002648:Child; D002650:Child Abuse, Sexual; D019548:Crime Victims; D004249:DNA Damage / Q000502:physiology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D013315:Stress, Psychological / Q000503:physiopathology
chemical_list: D006854:Hydrocortisone
keywords: DNA damage; oxidative stress; sexual abuse; trauma