title: Spermatogonial cells: mouse, monkey and man comparison.
abstract: In all mammals, spermatogonia are defined as constituting the mitotic compartment of spermatogenesis including stem, undifferentiated and differentiating cell types, possessing distinct morphological and molecular characteristics. Even though the real nature of the spermatogonial stem cell and its regulation is still debated the general consensus holds that in steady-state spermatogenesis the stem cell compartment needs to balance differentiation versus self-renewal. This review highlights current understanding of spermatogonial biology, the kinetics of amplification and the signals directing spermatogonial differentiation in mammals. The focus will be on relevant similarities and differences between rodents and non human and human primates.
authors.affiliation: Fondazione Pasteur Cenci Bolognetti and Department of Anatomical, Histological, Forensic and Orthopedic Sciences-Section of Histology and Medical Embryology, Sapienza University of Rome, Via Antonio Scarpa, 14, 00161 Rome, Italy. Electronic address: carla.boitani@uniroma1.it.
authors.forename: Carla
authors.initials: C
authors.lastname: Boitani
authors.affiliation: Fondazione Pasteur Cenci Bolognetti and Department of Anatomical, Histological, Forensic and Orthopedic Sciences-Section of Histology and Medical Embryology, Sapienza University of Rome, Via Antonio Scarpa, 14, 00161 Rome, Italy. Electronic address: sara.dipersio@uniroma1.it.
authors.forename: Sara
authors.initials: S
authors.lastname: Di Persio
authors.affiliation: Fondazione Pasteur Cenci Bolognetti and Department of Anatomical, Histological, Forensic and Orthopedic Sciences-Section of Histology and Medical Embryology, Sapienza University of Rome, Via Antonio Scarpa, 14, 00161 Rome, Italy. Electronic address: valentina.esposito@uniroma1.it.
authors.forename: Valentina
authors.initials: V
authors.lastname: Esposito
authors.affiliation: Fondazione Pasteur Cenci Bolognetti and Department of Anatomical, Histological, Forensic and Orthopedic Sciences-Section of Histology and Medical Embryology, Sapienza University of Rome, Via Antonio Scarpa, 14, 00161 Rome, Italy. Electronic address: elena.vicini@uniroma1.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Vicini
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D000882:Haplorhini; D006801:Humans; D007700:Kinetics; D008297:Male; D051379:Mice; D008954:Models, Biological; D010641:Phenotype; D013093:Spermatogonia / Q000166:cytology*; D055153:Stem Cell Niche
keywords: Human; Mouse; Non-human primates; Spermatogonia; Spermatogonial stem cell niche; Spermatogonial stem cells