title: A meta-analysis of contagious caprine pleuropneumonia (CCPP) in Ethiopia.
abstract: This systematic literature review was initiated due to lack of comprehensive information on the status and distribution of contagious caprine pleuropneumonia (CCPP) in Ethiopia. The objectives of the review were thus to provide a pooled prevalence estimate of CCPP in the country and asses the level of in between study variance among the available reports. Manual and electronic search was conducted between 8th of January and 25th of June 2015. A total of twelve published articles and one MSc thesis was retrieved from 19 initially identified studies. Twenty five animal level datasets were extracted at regional level considering some hypothesized predictors. The retrieved data were summarized in a meta-analytical approach. Accordingly, the pooled prevalence estimate of CCPP was 25.7% (95% CI:20.9,31.0). The inverse variance square (I(2)) that explains the variation in effect size attributed to reports true heterogeneity was 95.7%.The sub-group analysis was also computed for assumed predictors including, age, sex, type of study population, production systems and regional states. Among these predictors, study population type revealed statistically significant difference (P<0.05). Accordingly, the prevalence estimate for samples collected at abattoir was 39.2%, while that of samples collected at field level was 22.4%. In the final model, type of study population fitted the multivariable meta-regression model accounting for 22.87% of the explainable proportion of heterogeneity among the presumed predictors. Evidence on isolation and confirmation of Mycoplasma capricolum subspp. capripneumonie in the country was obtained from five regional states. In conclusion, it is recommended to further investigate facilities related with transportation and collection premises along with potential role of sheep in the epidemiology of CCPP. Finally, the review emphasizes the need for monitoring the ongoing CCPP control intervention and introduces amendments based on the findings. Besides more surveys are needed in some of the regions where no or few valid data was available.
authors.affiliation: School of Veterinary Medicine, Hawassa University, P.O. Box 005, Hawassa, Ethiopia. Electronic address: kassahun7588@gmail.com.
authors.forename: Kassahun
authors.initials: K
authors.lastname: Asmare
authors.affiliation: College of Veterinary Medicine and Agriculture, Addis Ababa University, P.O. Box 34, Debre Zeit, Ethiopia.
authors.forename: Takele
authors.initials: T
authors.lastname: Abayneh
authors.affiliation: School of Veterinary Medicine, Hawassa University, P.O. Box 005, Hawassa, Ethiopia.
authors.forename: Solomon
authors.initials: S
authors.lastname: Mekuria
authors.affiliation: National Veterinary Institute, P.O. Box 19, Debre Zeit, Ethiopia.
authors.forename: Gelagay
authors.initials: G
authors.lastname: Ayelet
authors.affiliation: College of Veterinary Medicine, Haramaya University, P.O. Box 138, Dire Dawa, Ethiopia.
authors.forename: Berhanu
authors.initials: B
authors.lastname: Sibhat
authors.affiliation: Norwegian University of life Sciences, P.O. Box 8146 Dep., N-0033 Oslo, Norway.
authors.forename: Eystein
authors.initials: E
authors.lastname: Skjerve
authors.affiliation: International Livestock Research Institute (ILRI), P.O. Box 5689, Addis Ababa, Ethiopia.
authors.forename: Barbara
authors.initials: B
authors.lastname: Szonyi
authors.affiliation: International Livestock Research Institute (ILRI), P.O. Box 5689, Addis Ababa, Ethiopia.
authors.forename: Barbara
authors.initials: B
authors.lastname: Wieland
mesh_terms: D000818:Animals; D005002:Ethiopia / Q000453:epidemiology; D005260:Female; D015511:Goat Diseases / Q000453:epidemiology* / Q000517:prevention & control; D006041:Goats; D045623:Mycoplasma capricolum / Q000302:isolation & purification; D011002:Pleuropneumonia, Contagious / Q000453:epidemiology* / Q000517:prevention & control; D015995:Prevalence; D012756:Sheep
keywords: CCPP; Ethiopia; Goat; Meta-analysis; Sero-prevalence; Sheep