title: Disseminated anetoderma in a patient with nodal Epstein-Barr virus-associated classical Hodgkin lymphoma: Anetodermic form of a concurrent discordant cutaneous marginal zone lymphoma.
abstract: Patients with a lymphoma have an increased risk of developing a second lymphoproliferative disorder. The association of nodal Hodgkin lymphoma and primary cutaneous marginal zone lymphoma (MALT type) is exceptional, and only very few cases have been documented. Anetoderma represents a circumscribed loss or rarefication of elastic fibers. Different underlying processes may result in anetoderma, including cutaneous marginal zone lymphoma. We report a 50-year-old male patient with Epstein-Barr virus (EBV)-associated nodal Hodgkin lymphoma who presented with disseminated anetodermic skin lesions. Biopsies of the skin lesions revealed a B-cell infiltrate containing monoclonal plasma cells but without detection of EBV. The skin lesions represent an anetodermic form of primary cutaneous marginal zone lymphoma. It is the first case report of an association of anetodermic cutaneous marginal zone lymphoma and a synchronous EBV-associated nodal Hodgkin lymphoma.
authors.affiliation: Department of Pathology, Muzaffarnagar Medical College & Hospital, Muzaffarnagar, Uttar Pradesh.
authors.forename: Anupam
authors.initials: A
authors.lastname: Varshney
authors.affiliation: Department of Dermatology, Muzaffarnagar Medical College & Hospital, Muzaffarnagar, Uttar Pradesh.
authors.forename: Tarang
authors.initials: T
authors.lastname: Goyal
authors.affiliation: Consultant Dermatologist, Skin Diseases Centre Nashik, India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Zawar
authors.affiliation: Kempf und Pfaltz Histologische Diagnostik, Research Unit, Zurich, Switzerland.
authors.forename: Marianne
authors.initials: M
authors.lastname: Tinguely
authors.affiliation: Kempf und Pfaltz Histologische Diagnostik, Research Unit, Zurich, Switzerland.
authors.forename: Werner
authors.initials: W
authors.lastname: Kempf
mesh_terms: D057088:Anetoderma / Q000209:etiology*; D020031:Epstein-Barr Virus Infections / Q000150:complications; D004854:Herpesvirus 4, Human; D006689:Hodgkin Disease / Q000150:complications* / Q000821:virology; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications*; D008297:Male; D008875:Middle Aged