title: Spontaneous brain tumor imaging of aged rat by crystal X-ray interferometer-based phase-contrast X-ray CT.
abstract: BACKGROUND
  Crystal X-ray interferometer-based phase-contrast X-ray computed tomography (C-PCCT) enables the depiction of internal structures of biological tissue without contrast agents.
  
  
  OBJECTIVE
  To determine the advantage of this technique in visualizing detailed morphological structures of a rare spontaneous brain tumor in an aged rat.
  
  
  METHODS
  An aged rat's spontaneous brain tumor was imaged by C-PCCT without contrast agent. Three-dimensional (3D) images of the tumor microvasculature were reconstructed and compared with pathological pictures.
  
  
  RESULTS
  C-PCCT depicted the tumor's various pathological features clearly, e.g. its cell density and vasculature, and blood clots caused by hemorrhaging and/or hematomas. The obtained images resembled pathological pictures with a magnification of ×20 and were used to reconstruct 3D images of the tumor vascularity up to approximately 26 µm in diameter.
  
  
  CONCLUSIONS
  Since C-PCCT is able to depict various pathological conditions, it might be useful for cancer research.
authors.affiliation: Allied Health Sciences, Kitasato University, Sagamihara, Japan; Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
authors.forename: Thet-Thet
authors.initials: TT
authors.lastname: Lwin
authors.affiliation: Allied Health Sciences, Kitasato University, Sagamihara, Japan; Kitasato University, School of Medicine, Sagamihara, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Yoneyama
authors.affiliation: Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan; Kitasato University, School of Medicine, Sagamihara, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Hara
authors.affiliation: Allied Health Sciences, Kitasato University, Sagamihara, Japan; Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohbu
authors.affiliation: Allied Health Sciences, Kitasato University, Sagamihara, Japan; Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Maruyama
authors.affiliation: Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Taguchi
authors.affiliation: Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Esashi
authors.affiliation: Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Matsushima
authors.affiliation: Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Terazaki
authors.affiliation: High Energy Accelerator Research Organization, Tsukuba, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hyodo
authors.affiliation: Allied Health Sciences, Kitasato University, Sagamihara, Japan; Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
authors.forename: Tohoru
authors.initials: T
authors.lastname: Takeda
keywords: Crystal X-ray interferometer-based phase-contrast X-ray CT (C-PCCT); aged rat; computed tomography (CT); spontaneous brain tumor