title: Mathematical modeling of cardiac growth and remodeling.
abstract: This review provides an overview of the current state of mathematical models of cardiac growth and remodeling (G&R). We concisely describe the experimental observations associated with cardiac G&R and discuss existing mathematical models that describe this process. To facilitate the discussion, we have organized the G&R models in terms of (1) the physical focus (biochemical vs mechanical) and (2) the process that they describe (myocyte hypertrophy vs extracellular matrix remodeling). The review concludes with a discussion of some possible directions that can advance the existing state of cardiac G&R mathematical modeling. WIREs Syst Biol Med 2016, 8:211-226. doi: 10.1002/wsbm.1330 For further resources related to this article, please visit the WIREs website.
authors.affiliation: Department of Mechanical Engineering, Michigan State University, East Lansing, MI, USA.
authors.forename: L C
authors.initials: LC
authors.lastname: Lee
authors.affiliation: California Medical Innovations Institute, San Diego, CA, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Kassab
authors.affiliation: Department of Surgery, University of California at San Francisco, San Francisco, CA, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Guccione
mesh_terms: D058406:Cardiac Resynchronization Therapy; D005109:Extracellular Matrix / Q000378:metabolism; D006331:Heart Diseases / Q000503:physiopathology / Q000628:therapy; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008962:Models, Theoretical; D009206:Myocardium / Q000378:metabolism; D020257:Ventricular Remodeling