title: Mex3B: a coreceptor to present dsRNA to TLR3.
abstract: Toll-Like Receptors (TLRs) play critical roles in the early innate immune response to invading pathogens by sensing microorganisms; a number of accessory molecules have been shown to assist microbial recognition by TLRs. In a recent paper in Cell Research, Yang et al. demonstrate that Mex3B is associated with TLR3 in the endosomes and promotes dsRNA binding and proteolytic processing of TLR3, suggesting that Mex3B acts as a coreceptor of TLR3 in response to dsRNA.
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Geng
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Xuqiu
authors.initials: X
authors.lastname: Lei
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.|Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Flavell
mesh_terms: D011992:Endosomes / Q000378:metabolism; D012330:RNA, Double-Stranded / Q000378:metabolism; D015398:Signal Transduction; D051196:Toll-Like Receptor 3; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D012330:RNA, Double-Stranded; D051196:Toll-Like Receptor 3; D051193:Toll-Like Receptors