title: [VESTIBULAR AND THERMOPROTECTIVE PROPERTIES OF A NEW ACTOPROTECTOR].
abstract: In experiments with rats, a new 3-hydroxypyridine (3-HP) derivative--2-ethyl-6-methyl-3-hydroxypyridine L-asparaginate (30 mg/kg)--exhibited a strong vestibuloprotective effect which was better than of promethazine (50 mg/kg), a well-known vestibuloprotector Besides the new actoprotector was competitive with another 3-HP derivative, namely, mexidol (ethyl-methyl-hydroxypyridine succinate) (100 mg/kg). Moreover, a distinct thermoprotective effect of 2-ethyl-6-methyl-3-hydroxypyridine L-asparaginate (30 mg/kg) in mice was not worse than that of mexidol or metaprot (ethylthiobenzimidasol, former name bimethy), an actoprotector with good thermoprotective properties. To conclude, owing to the membrane-protective and antioxidative qualities, the vestibuloprotective and thermoprotective properties of 2-ethyl-6-methyl-3-hydroxypyridine L-asparaginate are better or competitive with the reference preparations.
authors.forename: V V
authors.initials: VV
authors.lastname: Yasnetsov
authors.forename: E G
authors.initials: EG
authors.lastname: Tsublova
authors.forename: Vik V
authors.initials: VV
authors.lastname: Yasnetsov
authors.forename: S Ya
authors.initials: SY
authors.lastname: Skachilova
authors.forename: S K
authors.initials: SK
authors.lastname: Karsanova
authors.forename: N A
authors.initials: NA
authors.lastname: Chelnaya
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D009041:Motion Sickness / Q000188:drug therapy* / Q000503:physiopathology; D010847:Picolines / Q000494:pharmacology*; D051381:Rats; D014722:Vestibule, Labyrinth / Q000187:drug effects* / Q000502:physiology
chemical_list: D000975:Antioxidants; D010847:Picolines; C070020:emoxypine succinate; C009820:6-methyl-2-ethyl-3-hydroxypyridine