title: Synthesis of indole-annulated sulfur heterocycles using copper-catalysed C-N coupling and palladium-catalysed direct arylation.
abstract: A simple and efficient method for the synthesis of biologically relevant 5H-benzo[4,5][1,3]thiazino[3,2-a]indoles and 5,7-dihydroisothiochromeno[3,4-b]indoles has been developed via intramolecular copper catalysed Ullmann-type C-N coupling and palladium catalysed direct arylation from the corresponding precursors 2-(2-bromobenzylthio)-1H-indole and 2-(2-bromobenzylthio)-1-methyl-1H-indole, respectively, in good to excellent yields.
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science, Pilani, 333031 Rajasthan, India. anilkumar@pilani.bits-pilani.ac.in.
authors.forename: Ganesh M
authors.initials: GM
authors.lastname: Shelke
authors.forename: Mukund
authors.initials: M
authors.lastname: Jha
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D007211:Indoles; D010165:Palladium; D013455:Sulfur; D003300:Copper