title: The vascular clock system generates the intrinsic circadian rhythm of vascular contractility.
abstract: Many of the cardiovascular parameters or incidences of coronary artery diseases display circadian variations. These day/night time variances may be attributable to the diurnal change in vascular contractility. However, the molecular mechanism of the vascular clock system which generates the circadian variation of vascular contractility has remained largely unknown. Recently we found the existence of the intrinsic circadian rhythm in vascular contractility. A clock gene Rorα in vascular smooth muscle cells (VSMC) provokes the diurnal oscillatory change in the expression of Rho-associated kinase 2 (ROCK2), which induces the time-of-day-dependent variation in the agonist-induced phosphorylation of myosin light chain (MLC) and myofilament Ca(2+) sensitization. In this review, we introduce our recent findings with reference to the molecular basis of the biological clock system and the current literature concerning cardiovascular chronobiology.
authors.affiliation: Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Saito
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002320:Cardiovascular Physiological Phenomena / Q000235:genetics*; D002940:Circadian Rhythm / Q000235:genetics* / Q000502:physiology*; D015870:Gene Expression; D006801:Humans; D009119:Muscle Contraction / Q000235:genetics / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D009210:Myofibrils / Q000378:metabolism; D018994:Myosin Light Chains / Q000378:metabolism; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1 / Q000502:physiology; D010766:Phosphorylation / Q000235:genetics; D054460:rho-Associated Kinases / Q000235:genetics / Q000378:metabolism
chemical_list: D018994:Myosin Light Chains; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; C539738:RORA protein, human; D054460:rho-Associated Kinases; D002118:Calcium