title: Evaluation of Pericardial Fluid C-Type Natriuretic Peptide Levels in Patients Undergoing Coronary Bypass Surgery.
abstract: BackgroundNeurohumoral and hemodynamic mechanisms have an effect on cardiac activity. C-type natriuretic peptide (CNP) is accessible in the cardiovascular system. The aim of this study was to determine whether CNP concentrations in pericardial fluid and blood are related to cardiac dysfunction in patients undergoing coronary artery bypass graft surgery.Materials and MethodsIn this study, 40 patients undergoing coronary artery bypass grafting were enrolled. The patients were separated into two groups according to left ventricular (LV) ejection fraction (EF): group 1 contained 28 patients with normal LV systolic function (LVEF ≥ 50%) and group 2 contained 12 patients with impaired LV systolic function (LVEF < 45%). Plasma and pericardial fluid samples were acquired during surgery to measure CNP levels.ResultsIn group 1, CNP levels were detected to be 0.46 ± 0.10 ng/mL in plasma and 0.66 ± 0.8 ng/mL in pericardial liquid. In group 2, these levels were 0.51 ± 0.09 and 0.79 ± 0.12 ng/mL, respectively. CNP levels were determined to be significantly higher in patients with low EF compared with those with normal EF in pericardial fluid concentrations (p= 0.013).ConclusionsCNP level in pericardial fluid is a more sensitive and proper marker of LV dysfunction than CNP levels in plasma. To the best of our knowledge, this study is the first to examine pericardial fluid CNP levels in patients undergoing coronary artery bypass surgery. It may have a valuable role in organizing cardiac remodeling and hypertrophy.
authors.affiliation: Department of Cardiovascular Surgery, Medical School, Trakya University, Edirne, Turkey.
authors.forename: Orkut
authors.initials: O
authors.lastname: Guclu
authors.affiliation: Department of Cardiovascular Surgery, Medical School, Dicle University, Diyarbakir, Turkey.
authors.forename: Oguz
authors.initials: O
authors.lastname: Karahan
authors.affiliation: Department of Cardiology, Isparta State Hospital, Isparta, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karabacak
authors.affiliation: Department of Cardiovascular Surgery, Medical School, Trakya University, Edirne, Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Yuksel
authors.affiliation: Department of Cardiovascular Surgery, Medical School, Trakya University, Edirne, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Huseyin
authors.affiliation: Department of Cardiovascular Surgery, Medical School, Dicle University, Diyarbakir, Turkey.
authors.forename: Binali
authors.initials: B
authors.lastname: Mavitas
mesh_terms: D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000378:metabolism; D001026:Coronary Artery Bypass / Q000009:adverse effects; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D020098:Natriuretic Peptide, C-Type / Q000097:blood / Q000378:metabolism*; D000069236:Pericardial Fluid / Q000378:metabolism*; D011237:Predictive Value of Tests; D012372:ROC Curve; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D020098:Natriuretic Peptide, C-Type