title: Application of the cultured epidermal autograft "JACE(®") for treatment of severe burns: Results of a 6-year multicenter surveillance in Japan.
abstract: BACKGROUND
  In the 1970s, Green et al. developed a method that involved culturing keratinocyte sheets and used for treatment of burns. Since then, the take rate of cultured epidermal autograft (CEA) onto fascia, granulation tissue, or allografts has been extensively reported, while that on an artificial dermis in a large case series is not. Moreover, the contribution of CEA to patient survival has not been analyzed in a multicenter study.
  
  
  METHODS
  We conducted a 6-year multicenter surveillance on the application of the CEA "JACE(®") for treatment of burns >30% total body surface area (TBSA) across 118 Japanese hospitals. This surveillance included 216 patients and 718 graft sites for efficacy analysis. The CEA take rate at 4 weeks after grafting was evaluated, and safety was monitored until 52 weeks. In addition, the survival curve obtained in this study and the data obtained from the Tokyo Burn Unit Association (TBUA) were compared.
  
  
  RESULTS
  The mean CEA take rates at week 4 were 66% (sites) and 68% (patients), and the rate on the artificial dermis was 65% for 226 sites. CEA application combined with wide split-thickness auto or patch autograft increased the CEA take rate. On comparison with the data obtained from the TBUA, which included data on individuals with burns of the same severity, CEA application was found to contribute to patient survival until 7 weeks after burn.
  
  
  CONCLUSIONS
  We reported the take rate of CEA based on a 6-year multicenter surveillance. From our results, we found that the application of CEA is a useful treatment for the patients with extensive burns.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. Electronic address: hmatsu-tki@umin.ac.jp.
authors.forename: Hajime
authors.initials: H
authors.lastname: Matsumura
authors.affiliation: Department of Advancing Acute Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi Aza Mizuhocho Mizuho-ku, Nagoya 467-8602, Japan. Electronic address: asakouab@gmail.com.
authors.forename: Asako
authors.initials: A
authors.lastname: Matsushima
authors.affiliation: Department of Trauma, Critical Care Medicine and Burn Center, Japan Community Healthcare Organization Chukyo Hospital, 1-1-10 Sanjo, Minami-Ku, Nagoya 457-8510, Japan. Electronic address: m.ueyama@gmail.com.
authors.forename: Masashi
authors.initials: M
authors.lastname: Ueyama
authors.affiliation: St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki, Kanagawa, 216-8511, Japan. Electronic address: kumano952@gmail.com.
authors.forename: Norio
authors.initials: N
authors.lastname: Kumagai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001830:Body Surface Area; D002056:Burns / Q000601:surgery*; D002478:Cells, Cultured / Q000637:transplantation*; D002648:Child; D002675:Child, Preschool; D004817:Epidermis / Q000637:transplantation*; D005260:Female; D006085:Graft Survival; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D008297:Male; D008875:Middle Aged; D016038:Skin Transplantation; D017768:Skin, Artificial; D046509:Tissue Culture Techniques; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult
keywords: Burn; Cultured epidermal autograft; Grafting; Multicenter surveillance