title: C(sp(2))-H Functionalization of 2H-Indazoles at C3-Position via Palladium(II)-Catalyzed Isocyanide Insertion Strategy Leading to Diverse Heterocycles.
abstract: Herein, we have reported an efficient Pd-catalyzed C-H functionalization of 2H-indazole at C3-position via an isocyanide insertion strategy for the synthesis of unprecedented benzoxazinoindazoles, indazoloquinaoxalines and benzoxazinoindazolones for the first time. Our new method provides an operationally simple and versatile route for a selective synthesis of 2-(2H-indazol-2-yl)phenols. Furthermore, we developed a sequential one-pot strategy for the synthesis of benzoxazinoindazolone under metal-oxidant-free conditions. We also achieved the isocyanide insertion between C(sp(2))-H and oxygen heteroatom for the first time. The key features of the present protocol are construction of 4 bonds in one-pot, synthesis of new skeletally diverse scaffolds, broad substrate scope, high yields and environmentally benign conditions.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Hyderabad , Kandi, Sangareddy, Medak District 502285, Telangana, India.
authors.forename: Shinde
authors.initials: S
authors.lastname: Vidyacharan
authors.affiliation: Department of Chemistry, Indian Institute of Technology Hyderabad , Kandi, Sangareddy, Medak District 502285, Telangana, India.
authors.forename: Arumugavel
authors.initials: A
authors.lastname: Murugan
authors.affiliation: Department of Chemistry, Indian Institute of Technology Hyderabad , Kandi, Sangareddy, Medak District 502285, Telangana, India.
authors.forename: Duddu S
authors.initials: DS
authors.lastname: Sharada