title: The role of dehydroepiandrosterone (DHEA) in schizophrenia.
abstract: Neurosteroid dehydropiandrosterone (DHEA) and its sulphate (DHEAS) are reported to have modulatory effects on neuronal excitabillity and synaptic plasticity. DHEA and DHEAS are synthesized in central and peripheral nervous system from cholesterol or steroidal precursors imported from peripheral sources. There is accumulating evidence that alterations in DHEA(S) levels may be involved in the pathophysiology of schizophrenia. The possible effects of DHEA(S) as augmentation therapy in schizophrenia, related to psychological and somatic aspects of this disease, are discussed.
authors.affiliation: Department of Psychiatry, University Hospital Center Zagreb, Kišpatićeva 12, 10 000 Zagreb, Croatia, bjanka.vuksan@gmail.com.
authors.forename: Bjanka
authors.initials: B
authors.lastname: Vuksan-Ćusa
authors.forename: Marina
authors.initials: M
authors.lastname: Šagud
authors.forename: Iva
authors.initials: I
authors.lastname: Radoš
mesh_terms: D003687:Dehydroepiandrosterone / Q000627:therapeutic use*; D006801:Humans; D018377:Neurotransmitter Agents / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D018377:Neurotransmitter Agents; D003687:Dehydroepiandrosterone