title: NDUFA12L mitochondrial complex-I assembly factor: Implications for taupathies.
abstract: There is a strong correlation between taupathies and the development and progression of neurodegenerative disorders. Abnormal tau becomes hyperphosphorylated and dissociated from microtubules with the aggregation of intracellular tau aggregates within the patient's brain. The current review is divided into two broad sections. In the first section we discuss the molecular biology and the clinicopathologic features of taupathies. While in the second section we discuss the relationship between mitochondrial complex-I and taupathies. Polymorphism in NDUFA12L may be a crucial factor for development of neurodegenerative taupathies. Thus NDUFA12L screening may be an early biomarker for identifying risk groups for such disorders.
authors.affiliation: Toxicology Department, Mansoura University, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Salama
authors.affiliation: Clinical Pharmacology Dept, Menoufia Medical School, Menoufia University, Egypt.
authors.forename: Wael M Y
authors.initials: WM
authors.lastname: Mohamed
keywords: Mitochondrial complex; Neurodegeneration; Taupathies