title: Bougainvinones A-H, Peltogynoids from the Stem Bark of Purple Bougainvillea spectabilis and Their Cytotoxic Activity.
abstract: Eight new peltogynoids, named bougainvinones A-H (1-8), were obtained from the stem bark of Bougainvillea spectabilis. Their structures were elucidated by means of physical data (1D and 2D NMR, HRESIMS) and single-crystal X-ray crystallographic analyses. The peltogynoids, a rare type of modified flavonoids, are reported for the first time from this species of the genus Bougainvillea. All isolated compounds were evaluated for their cytotoxic effects against five cancer cell lines including KB, Hela S-3, HT-29, MCF-7, and HepG2. Among them, compound 7 showed cytotoxicity against five cancer cell lines with IC50 values in the 7.4-9.7 μM range, and compounds 2 and 3 exhibited cytotoxicity against the KB cell line with IC50 values of 6.6 and 9.0 μM.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University , Bangkok 10330, Thailand.|Sai Gon University , Ho Chi Minh City 748355, Vietnam.
authors.forename: Lien T M
authors.initials: LT
authors.lastname: Do
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University , Bangkok 10330, Thailand.
authors.forename: Thammarat
authors.initials: T
authors.lastname: Aree
authors.affiliation: Natural Products Research Section, Research Division, National Cancer Institute, Bangkok 10400, Thailand.
authors.forename: Pongpun
authors.initials: P
authors.lastname: Siripong
authors.affiliation: Sai Gon University , Ho Chi Minh City 748355, Vietnam.
authors.forename: Tuyen N K
authors.initials: TN
authors.lastname: Pham
authors.affiliation: University of Science, National University - Ho Chi Minh City , Ho Chi Minh City 748355, Vietnam.
authors.forename: Phung K P
authors.initials: PK
authors.lastname: Nguyen
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University , Bangkok 10330, Thailand.
authors.forename: Santi
authors.initials: S
authors.lastname: Tip-Pyang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D008968:Molecular Conformation; D015394:Molecular Structure; D039281:Nyctaginaceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; C000610547:bougainvinone G