title: Actin' on HIV: How Dendritic Cells Spread Infection.
abstract: Dendritic cells (DCs) capture HIV particles and transmit them to CD4 T cells. In a recent article published in Cell, Ménager and Littman (2016) perform an shRNA screen in DCs and find that actin nucleation and stabilization regulate HIV uptake and maintain the virus on membrane protrusions for efficient transfer.
authors.affiliation: Institut Pasteur, Department of Virology, Virus & Immunity Unit, Paris 75015, France; CNRS URA 3015, Paris 75015, France. Electronic address: ddonahue@pasteur.fr.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Donahue
authors.affiliation: Institut Pasteur, Department of Virology, Virus & Immunity Unit, Paris 75015, France; CNRS URA 3015, Paris 75015, France; Vaccine Research Institute, Creteil 94010, France. Electronic address: schwartz@pasteur.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Schwartz
mesh_terms: D000199:Actins / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000199:Actins