title: B Cells Promote Pancreatic Tumorigenesis.
abstract: Three recent studies, approaching the question from different angles and using different and/or overlapping models, provide compelling evidence for the involvement of tumor-infiltrating B cells in the initiation and progression of pancreatic ductal adenocarcinoma. These studies highlight the need for a better understanding of pancreatic tumor-immune system interactions and the immunologic mechanisms that promote or inhibit tumorigenesis, paving the way for better treatment strategies.
authors.affiliation: Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts. Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.
authors.forename: Ali
authors.initials: A
authors.lastname: Roghanian
authors.affiliation: Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.
authors.forename: Christopher
authors.initials: C
authors.lastname: Fraser
authors.affiliation: Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.
authors.forename: Marianna
authors.initials: M
authors.lastname: Kleyman
authors.affiliation: Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts. jchen@mit.edu.
authors.forename: Jianzhu
authors.initials: J
authors.lastname: Chen
mesh_terms: D001402:B-Lymphocytes; D021441:Carcinoma, Pancreatic Ductal; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D006801:Humans; D010179:Pancreas