title: Biomaterial-based regional chemotherapy: Local anticancer drug delivery to enhance chemotherapy and minimize its side-effects.
abstract: Since the majority of anticancer pharmacological agents affect not only cancer tissue but also normal cells, chemotherapy is usually accompanied with severe side effects. Regional chemotherapy, as the alternative version of conventional treatment, leads to the enhancement of the therapeutic efficiency of anticancer drugs and, simultaneously, reduction of toxic effects to healthy tissues. This paper provides an insight into different approaches of local delivery of chemotherapeutics, such as the injection of anticancer agents directly into tumor tissue, the use of injectable in situ forming drug carriers or injectable platforms in a form of implants. The wide range of biomaterials used as reservoirs of anticancer drugs is described, i.e. poly(ethylene glycol) and its copolymers, polyurethanes, poly(lactic acid) and its copolymers, poly(ɛ-caprolactone), polyanhydrides, chitosan, cellulose, cyclodextrins, silk, conducting polymers, modified titanium surfaces, calcium phosphate based biomaterials, silicone and silica implants, as well as carbon nanotubes and graphene. To emphasize the applicability of regional chemotherapy in cancer treatment, the commercially available products approved by the relevant health agencies are presented.
authors.affiliation: Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland. Electronic address: katarzyna.krukiewicz@polsl.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Krukiewicz
authors.affiliation: Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland. Electronic address: jerzy.zak@polsl.pl.
authors.forename: Jerzy K
authors.initials: JK
authors.lastname: Zak
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000737:chemistry* / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry* / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D011108:Polymers / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D011108:Polymers
keywords: Anticancer implants; Biomaterials; Drug carriers; Local drug delivery; Regional chemotherapy