title: Blood glucose and lipid concentrations after overload are not associated with the risk of alcohol relapse.
abstract: OBJECTIVE
  There is evidence for the functioning of feedback between alcohol consumption and fat (positive) and carbohydrate (negative) intake. We tried to verify the hypothesis that blood glucose and lipid concentration in a fasting state and after loading may affect the risk of relapse in alcohol-dependent male patients during withdrawal therapy.
  
  
  METHODS
  Blood glucose, total cholesterol (TC) and triglycerides (TG) were determined at the beginning of the study, and again after 4 weeks and 6 months of observation in 54 alcohol-dependent male patients treated against drinking relapse. Glucose concentration was checked after fasting and 2h after loading with a 75 g water solution of glucose, and blood lipids were determined on an empty stomach and 5h after butter loading (0.5 g of butter per kilogram of body mass).
  
  
  RESULTS
  Patients who relapsed compared to subjects who remained abstinent during the 6-month observation did not differ significantly in relation to blood glucose, TC or TG blood concentrations, either in a fasting state or after loading. Patients with an initial above-median increase in TG blood concentration after butter loading (>38%) before the beginning of the study, and who smoked cigarettes with a greater content of nicotine and tar, preferred vodka and had lower values of aminotransferases.
  
  
  CONCLUSIONS
  Fasting and postprandial blood glucose, TC and TG concentrations had no relationship with the outcome of anti-relapse treatment. However, they presented some associations with the pathomechanism of addiction to nicotine.
authors.affiliation: Department of Vascular and Internal Medicine, Faculty of Health Sciences, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus Universisty, Toruń, Poland; Clinic of Vascular and Internal Diseases, Jan Biziel University Hospital No. 2, Bydgoszcz, Poland. Electronic address: budz@cps.pl.
authors.forename: Jacek
authors.initials: J
authors.lastname: Budzyński
authors.affiliation: Department of Psychiatric Nursing, Faculty of Health Sciences, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Ziółkowski
authors.affiliation: Department of Vascular and Internal Medicine, Faculty of Health Sciences, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus Universisty, Toruń, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Kłopocka
authors.affiliation: Department of Psychiatric Nursing, Faculty of Health Sciences, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland.
authors.forename: Damian
authors.initials: D
authors.lastname: Czarnecki
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000097:blood*; D001786:Blood Glucose; D005215:Fasting; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D012008:Recurrence
chemical_list: D001786:Blood Glucose; D008055:Lipids
keywords: Alcohol relapse risk; Blood glucose; Glucose tolerance test; Postprandial lipemia; Total cholesterol blood; Triglycerides blood