title: Inulin and Fibersol-2 Combined Have Hypolipidemic Effects on High Cholesterol Diet-Induced Hyperlipidemia in Hamsters.
abstract: The resistant carbohydrates, inulin, and Fibersol-2, belong to soluble dietary fibers and are considered important prebiotics that maintain biological functions, including glucose homeostasis, lipid regulation, colon disease prevention, and prebiotics characteristics. However, few studies have investigated Fibersol-2 alone or in combination with inulin to assess a pooled effect on modulation of hyperlipidemia. We aimed to investigate the effects of this combined supplement (defined as InF) on hamsters fed a 0.2% cholesterol and 10% lard diet (i.e., high-cholesterol diet, HCD) to induce hyperlipidemia. A total of 40 male hamsters were randomly assigned to five groups (n = 8 per group) for treatment: standard diet, vehicle (control); or vehicle or InF supplementation by oral gavage at 0, 864, 1727, or 2591 mg/kg/day for eight weeks, designated HCD, InF-1X, InF-2X, and InF-3X groups, respectively. The hypolipidemic efficacy and safety of InF supplementation was assessed by serum lipid indexes, hepatic and fecal lipid content, and histology. InF supplementation significantly improved serum levels of triacylglycerol (TG) and low-density lipoprotein cholesterol (LDL-C) and the ratio of LDL-C/HDL-C after two-week treatment, and reduced serum total cholesterol (TC) levels after four-week administration. After eight-week supplementation, InF supplementation dose-dependently improved serum levels of TC, TG, HDL-C, and LDL-C; LDL-C/HDL-C ratio; and hepatic TC and TG levels. It inhibited TC absorption by feces elimination. Our study provides experiment-based evidence to support that this prebiotics remedy may be useful in preventing or treating hyperlipidemia.
authors.affiliation: Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 33301, Taiwan. magicpica521@gmail.com.
authors.forename: Wen-Ching
authors.initials: WC
authors.lastname: Huang
authors.affiliation: Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 33301, Taiwan. 1031303@ntsu.edu.tw.|Department of Orthopedic Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan. 1031303@ntsu.edu.tw.
authors.forename: Che-Li
authors.initials: CL
authors.lastname: Lin
authors.affiliation: Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 33301, Taiwan. 1041302@ntsu.edu.tw.
authors.forename: Yi-Ju
authors.initials: YJ
authors.lastname: Hsu
authors.affiliation: Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 33301, Taiwan. 1021301@ntsu.edu.tw.|Department of Orthopedic Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan. 1021301@ntsu.edu.tw.|School of Nutrition and Health Sciences, Taipei Medical University, Taipei City 11031, Taiwan. 1021301@ntsu.edu.tw.
authors.forename: Yen-Shuo
authors.initials: YS
authors.lastname: Chiu
authors.affiliation: Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 33301, Taiwan. 1021302@ntsu.edu.tw.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Chen
authors.affiliation: Z-Plus Biotechnology Co., Ltd., Hami St., Datong Dist., Taipei City 10367, Taiwan. minfang58@gmail.com.
authors.forename: Ming-Fang
authors.initials: MF
authors.lastname: Wu
authors.affiliation: Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 33301, Taiwan. john5523@ntsu.edu.tw.
authors.forename: Chi-Chang
authors.initials: CC
authors.lastname: Huang
authors.affiliation: Department of Food and Nutrition, Providence University, Taichung City 43301, Taiwan. mfwang@pu.edu.tw.
authors.forename: Ming-Fu
authors.initials: MF
authors.lastname: Wang
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D006224:Cricetinae; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy* / Q000209:etiology; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D007444:Inulin / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D056692:Prebiotics / Q000008:administration & dosage; D014280:Triglycerides / Q000378:metabolism
chemical_list: D002791:Cholesterol, Dietary; D004041:Dietary Fats; D004043:Dietary Fiber; D000960:Hypolipidemic Agents; D008055:Lipids; D056692:Prebiotics; D014280:Triglycerides; D007444:Inulin; D002784:Cholesterol; C029310:lard
keywords: high-cholesterol diet; hypolipidemic; inulin; lipid-profiles; resistant maltodextrin