title: Meroterpenoid enantiomers from Ganoderma sinensis.
abstract: Zizhines A-F (1-6), six pairs of new meroterpenoid enantiomers and a known meroterpenoid (7) were isolated from the fruiting bodies of Ganoderma sinensis. The structures and absolute configurations of the new substances were assigned by spectroscopic and computational methods. All the compounds apart from 7 were evaluated for their inhibition on extracellular matrix component (fibronectin) generation by using TGF-β1-induced rat kidney tubular epithelial cells. Although none of them was found to be active in these cells, the present findings add new facets for the chemistry of Ganoderma.
authors.affiliation: Guangdong Pharmaceutical University, Guangzhou 510006, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Cao
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Yuquan Road 19, Beijing 100049, PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: yxcheng@mail.kib.ac.cn.
authors.forename: Yong-Xian
authors.initials: YX
authors.lastname: Cheng
authors.affiliation: Guangdong Pharmaceutical University, Guangzhou 510006, PR China. Electronic address: shmwang@sina.com.
authors.forename: Shu-Mei
authors.initials: SM
authors.lastname: Wang
mesh_terms: D000818:Animals; D002460:Cell Line; D004847:Epithelial Cells / Q000187:drug effects*; D005109:Extracellular Matrix / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism; D032902:Ganoderma / Q000737:chemistry*; D007684:Kidney Tubules / Q000166:cytology; D015394:Molecular Structure; D051381:Rats; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification; D053773:Transforming Growth Factor beta1 / Q000494:pharmacology
chemical_list: D005353:Fibronectins; D013729:Terpenes; D053773:Transforming Growth Factor beta1
keywords: Extracellular matrix production; Fornicin A (PubChem CID:16086601); Ganoderma sinensis; Meroterpenoids; Zizhines A–F