title: Cerebral white matter correlates of delay discounting in adolescents.
abstract: The adolescent brain undergoes extensive structural white matter (WM) changes. Adolescence is also a critical time period during which cognitive, emotional and social maturation occurs in transition into adulthood. Compared to adults, adolescents are generally more impulsive with increased risk-taking behaviors. The goal of this study is to examine whether adolescent impulsivity may be related to cerebral WM maturation. In 89 healthy adolescents, we assessed impulsivity using the delay discounting task, and MRI WM volumes in brain regions previously implicated in delay discounting behaviors. We found that smaller delay discounting AUC (area under the curve) was associated with larger WM volumes in orbitofrontal, dorsolateral and medial prefrontal cortices (PFC) and motor cortex. There were no significant effects of AUC on WM volumes within somatosensory brain regions. In our sample, younger age was significantly associated with greater WM volumes in orbitofrontal and dorsolateral PFC subregions. Even after accounting for age-related effects, preference for immediate rewards (or greater impulsivity) still correlated with larger WM volumes in prefrontal regions known to mediate cognitive control. Our findings lend further support to the notion that reduced brain WM maturity may limit the ability in adolescents to forgo immediate rewards leading to greater impulsivity.
authors.affiliation: Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA. Electronic address: beng-ho@uiowa.edu.
authors.forename: Beng-Choon
authors.initials: BC
authors.lastname: Ho
authors.affiliation: Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Koeppel
authors.affiliation: Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
authors.forename: Amy B
authors.initials: AB
authors.lastname: Barry
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D019540:Area Under Curve; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D002648:Child; D065786:Delay Discounting / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D013223:Statistics as Topic; D066127:White Matter / Q000033:anatomy & histology* / Q000000981:diagnostic imaging
keywords: Addiction; Connectivity; Impulsivity; MRI; Neurodevelopment; Neuroimaging