title: [Analysis of Clinical Characteristics in 595 Patients with Herb-induced Liver Injury].
abstract: OBJECTIVE
  To observe clinical characteristics of herb-induced liver injury (HILI).
  
  
  METHODS
  General conditions, medical history, clinical manifestations, biochemical indices, prognosis, and Roussed Uclaf Causality Assessment Method (RUCAM) scores were retrospectively analyzed in 595 inpatients at 302 Military Hospital between January 2009 and January 2014.
  
  
  RESULTS
  There were 423 cases (accounting for 71.1%) were females with multiple onset age ranging 41 to 50 years old. The median time from starting Chinese herbs to the occurrence of liver injury (LI) was 30 days (15-75 days), and 511 cases (85.9%) were classified as hepatocellular injury. Chinese herbs inducing HILI were mainly used for skin disease (102 cases, 17.1%), osteoarticular disease (57 cases, 9.6%), and gastrointestinal disease (49 cases, 8.2%), covering 207 kinds of Chinese patent medicines. Polygonum multiflorum, Psoralea corylifolia, and Corydalis ambigua were often seen in Chinese prescriptions. In RUCAM scoring, 451 HILI patients (accounting for 74.1%) were very possibly associated with Chinese herbs. Liver failure occurred in 47 HILI patients (accounting for 7.9%), cirrhosis in 45 patients (accounting for 7.6%), chronic HILI in 80 patients (accounting for 13.4%), 27 (4.5%) died, and only 2 (0.3%) underwent liver transplantation.
  
  
  CONCLUSIONS
  Chinese herbs could cause LI or even death. Attention should be paid to herbal hepatotoxicity and improving monitoring system of HILI.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yong-gang
authors.initials: YG
authors.lastname: Li
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Wang
authors.forename: Jia-bo
authors.initials: JB
authors.lastname: Wang
authors.forename: Rui-lin
authors.initials: RL
authors.lastname: Wang
authors.forename: Li-fu
authors.initials: LF
authors.lastname: Wang
authors.forename: Ya-kun
authors.initials: YK
authors.lastname: Meng
authors.forename: Zhong-xia
authors.initials: ZX
authors.lastname: Wang
authors.forename: He
authors.initials: H
authors.lastname: Xiao Xiao
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011379:Prognosis; D012189:Retrospective Studies