title: Developmental Dynamics of Rett Syndrome.
abstract: Rett Syndrome was long considered to be simply a disorder of postnatal development, with phenotypes that manifest only late in development and into adulthood. A variety of recent evidence demonstrates that the phenotypes of Rett Syndrome are present at the earliest stages of brain development, including developmental stages that define neurogenesis, migration, and patterning in addition to stages of synaptic and circuit development and plasticity. These phenotypes arise from the pleotropic effects of MeCP2, which is expressed very early in neuronal progenitors and continues to be expressed into adulthood. The effects of MeCP2 are mediated by diverse signaling, transcriptional, and epigenetic mechanisms. Attempts to reverse the effects of Rett Syndrome need to take into account the developmental dynamics and temporal impact of MeCP2 loss.
authors.affiliation: Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Feldman
authors.affiliation: Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Mriganka
authors.initials: M
authors.lastname: Sur
mesh_terms: D000818:Animals; D001921:Brain / Q000002:abnormalities* / Q000378:metabolism / Q000503:physiopathology*; D002465:Cell Movement; D044127:Epigenesis, Genetic; D006801:Humans; D009473:Neuronal Plasticity; D010641:Phenotype; D015518:Rett Syndrome / Q000196:embryology* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D015398:Signal Transduction; D009435:Synaptic Transmission