title: Rapid Normalization of High Glutamic Acid Decarboxylase Autoantibody Titers and Preserved Endogenous Insulin Secretion in a Patient with Diabetes Mellitus: A Case Report and Literature Review.
abstract: A 59-year-old Japanese woman developed diabetes mellitus without ketoacidosis in the presence of glutamic acid decarboxylase autoantibody (GADA) (24.7 U/mL). After the amelioration of her hyperglycemia, the patient had a relatively preserved serum C-peptide level. Her endogenous insulin secretion capacity remained almost unchanged during 5 years of insulin therapy. The patient's GADA titers normalized within 15 months. The islet-related autoantibodies, including GADA, are believed to be produced following the autoimmune destruction of pancreatic beta cells and are predictive markers of type 1 diabetes mellitus. Therefore, the transient appearance of GADA in our patient may have reflected pancreatic autoimmune processes that terminated without progression to insulin deficiency.
authors.affiliation: Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Japan.
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Ohara
authors.forename: Masanori
authors.initials: M
authors.lastname: Kaneko
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Furukawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Koike
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sone
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tanaka
authors.forename: Kenzo
authors.initials: K
authors.lastname: Kaneko
authors.forename: Kyuzi
authors.initials: K
authors.lastname: Kamoi
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002096:C-Peptide / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D018450:Disease Progression; D005260:Female; D005968:Glutamate Decarboxylase / Q000097:blood* / Q000187:drug effects; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000378:metabolism* / Q000627:therapeutic use; D000078790:Insulin Secretion; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D011237:Predictive Value of Tests; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D002096:C-Peptide; D007004:Hypoglycemic Agents; D007328:Insulin; D005968:Glutamate Decarboxylase