title: Stuck in a rut with old chemistry.
authors.affiliation: Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, Mölndal, 431 83, Sweden. Electronic address: Jonas.Bostrom@astrazeneca.com.
authors.forename: Jonas
authors.initials: J
authors.lastname: Boström
authors.affiliation: Neuroscience, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, 141 Portland Street, Cambridge, MA 02139, USA.
authors.forename: Dean G
authors.initials: DG
authors.lastname: Brown
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods* / Q000639:trends; D039301:Computers, Molecular / Q000639:trends; D015195:Drug Design; D006801:Humans