title: Circulating leptin and adiponectin concentrations in healthy exceptional longevity.
abstract: People reaching exceptional longevity free of major age-related diseases represent the paradigm of successful aging. Adipose tissue function declines as we age, potentially resulting in changes of circulating adipokines (e.g., leptin and adiponectin). Here, we measured circulating levels of leptin and adiponectin in healthy centenarians (n=81; 100-104 years) and younger elderly controls (n=46; 70-80 years). Centenarians had significant higher serum levels of leptin compared with controls (p<0.001), whereas no significant differences were observed for adiponectin. Further research including also other blood variables will be needed to elucidate whether high leptin levels could serve as a hallmark of healthy exceptional longevity.
authors.affiliation: Universidad Europea de Madrid, Spain; Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain. Electronic address: helios.pareja@uem.es.
authors.forename: Helios
authors.initials: H
authors.lastname: Pareja-Galeano
authors.affiliation: Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; GIDFYS, European University Miguel de Cervantes, Department of Health Sciences, Valladolid, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Santos-Lozano
authors.affiliation: Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
authors.forename: Fabian
authors.initials: F
authors.lastname: Sanchis-Gomar
authors.affiliation: Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Fiuza-Luces
authors.affiliation: Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; Facultad de Ciencias de la Salud y del Deporte, Universidad de Zaragoza, Huesca, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Garatachea
authors.affiliation: Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
authors.forename: Beatriz G
authors.initials: BG
authors.lastname: Gálvez
authors.affiliation: Universidad Europea de Madrid, Spain; Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
authors.affiliation: 2E Science, Robbio, Pavia, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: Emanuele
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008136:Longevity / Q000502:physiology*; D008297:Male
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin
keywords: Adipokines; Adiponectin; Adipose tissue; Centenarian; Leptin