title: Deposition, structure, physical and invitro characteristics of Ag-doped β-Ca3(PO4)2/chitosan hybrid composite coatings on Titanium metal.
abstract: Pure and five silver-doped (0-5Ag) β-tricalcium phosphate [β-TCP, β-Ca3(PO4)2]/chitosan composite coatings were deposited on Titanium (Ti) substrates and their properties that are relevant for applications in hard tissue replacements were assessed. Silver, β-TCP and chitosan were combined to profit from their salient and complementary antibacterial and biocompatible features.The β-Ca3(PO4)2 powders were synthesized by co-precipitation. The characterization results confirmed the Ag(+) occupancy at the crystal lattice of β-Ca3(PO4)2. The Ag-dopedβ-Ca3(PO4)2/chitosan composite coatings deposited by electrophoresis showed good antibacterial activity and exhibited negative cytotoxic effects towards the human osteosarcoma cell line MG-63. The morphology of the coatings was observed by SEM and their efficiency against corrosion of metallic substrates was determined through potentiodynamic polarization tests.
authors.affiliation: Centre for Nanoscience and Technology, Pondicherry University, Puducherry605 014, India.
authors.forename: Ram Kishore
authors.initials: RK
authors.lastname: Singh
authors.affiliation: Department of Biotechnology, Pondicherry University, Puducherry605 014, India.
authors.forename: Sharad
authors.initials: S
authors.lastname: Awasthi
authors.affiliation: Department of Biotechnology, Pondicherry University, Puducherry605 014, India.
authors.forename: Arunkumar
authors.initials: A
authors.lastname: Dhayalan
authors.affiliation: Department of Materials and Ceramics Engineering, University of Aveiro, CICECO, Aveiro3810 193, Portugal.
authors.forename: J M F
authors.initials: JM
authors.lastname: Ferreira
authors.affiliation: Centre for Nanoscience and Technology, Pondicherry University, Puducherry605 014, India. Electronic address: para_kanna@yahoo.com.
authors.forename: S
authors.initials: S
authors.lastname: Kannan
mesh_terms: D002130:Calcium Phosphates / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D003343:Corrosion; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D012834:Silver / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D014025:Titanium / Q000737:chemistry*
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C485817:beta-tricalcium phosphate; D012834:Silver; D048271:Chitosan; D014025:Titanium
keywords: Chitosan; Composite; Silver; Ti metal; β-Ca(3)(PO(4))(2)