title: Molecular and Epigenetic Mechanism Regulating Hypothalamic Kiss1 Gene Expression in Mammals.
abstract: After the discovery of hypothalamic kisspeptin encoded by the Kiss1 gene, the central mechanism regulating gonadotropin-releasing hormone (GnRH) secretion, and hence gonadotropin secretion, is gradually being unraveled. This has increased our understanding of the central mechanism regulating puberty and subsequent reproductive performance in mammals. Recently, emerging evidence has indicated the molecular and epigenetic mechanism regulating hypothalamic Kiss1 gene expression. Here we compile data regarding DNA and histone modifications in the Kiss1 promoter region and provide a hypothetic scheme of the molecular and epigenetic mechanism regulating Kiss1 gene expression in two populations of hypothalamic kisspeptin neurons, which govern puberty and subsequent reproductive performance via GnRH/gonadotropin secretion.
authors.affiliation: Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Uenoyama
authors.forename: Junko
authors.initials: J
authors.lastname: Tomikawa
authors.forename: Naoko
authors.initials: N
authors.lastname: Inoue
authors.forename: Teppei
authors.initials: T
authors.lastname: Goto
authors.forename: Shiori
authors.initials: S
authors.lastname: Minabe
authors.forename: Nahoko
authors.initials: N
authors.lastname: Ieda
authors.forename: Sho
authors.initials: S
authors.lastname: Nakamura
authors.forename: Youki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Kana
authors.initials: K
authors.lastname: Ikegami
authors.forename: Fuko
authors.initials: F
authors.lastname: Matsuda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohkura
authors.forename: Kei-Ichiro
authors.initials: K
authors.lastname: Maeda
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tsukamura
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D015870:Gene Expression / Q000502:physiology*; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000166:cytology* / Q000378:metabolism; D059648:Kisspeptins / Q000235:genetics* / Q000378:metabolism*; D008322:Mammals / Q000235:genetics; D009474:Neurons / Q000378:metabolism*
chemical_list: D006657:Histones; C106628:KISS1 protein, human; D059648:Kisspeptins