title: Gold Nanosphere Gated Mesoporous Silica Nanoparticle Responsive to Near-Infrared Light and Redox Potential as a Theranostic Platform for Cancer Therapy.
abstract: A gold/mesoporous silica hybrid nanoparticle (GoMe), which possesses the best of both conventional gold nanoparticles and mesoporous silica nanoparticles, such as excellent photothermal converting ability as well as high drug loading capacity and triggerable drug release, has been developed. In contrast to gold nanorod and other heat generating gold nanoparticles, GoMe is photothermal stable and can be repetitively activated through NIR irradiation. Doxorubicin loaded GoMe (DOX@GoMe) is sensitive to both NIR irradiation and intracellularly elevated redox potential. DOX@GoMe coupled with NIR irradiation exhibits a synergistic effect of photothermal therapy and chemotherapy in killing cancer cells. Furthermore, 64Cu-labeled GoMe can successfully detect the existence of clinically relevant spontaneous lung tumors in a urethane-induced lung cancer mouse model through PET imaging. Altogether, GoMe can be utilized as an effective theranostic platform for cancer therapy.
authors.forename: Bei
authors.initials: B
authors.lastname: Cheng
authors.forename: Huacheng
authors.initials: H
authors.lastname: He
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.forename: Stuart S
authors.initials: SS
authors.lastname: Berr
authors.forename: Jiang
authors.initials: J
authors.lastname: He
authors.forename: Daping
authors.initials: D
authors.lastname: Fan
authors.forename: Jiajia
authors.initials: J
authors.lastname: Zhang
authors.forename: Peisheng
authors.initials: P
authors.lastname: Xu
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D059248:Chemoradiotherapy / Q000379:methods; D003301:Copper Radioisotopes; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D005260:Female; D006046:Gold / Q000737:chemistry; D007259:Infrared Rays; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D053769:Nanocapsules / Q000737:chemistry* / Q000627:therapeutic use; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D010084:Oxidation-Reduction; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D016062:Porosity; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012822:Silicon Dioxide / Q000737:chemistry; D000068936:Theranostic Nanomedicine / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D003301:Copper Radioisotopes; D053769:Nanocapsules; D017319:Photosensitizing Agents; D019275:Radiopharmaceuticals; D006046:Gold; D012822:Silicon Dioxide; D004317:Doxorubicin