title: Species-specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins.
abstract: How host-virus co-evolutionary relationships manifest is one of the most intriguing issues in virology. To address this topic, the mammal-lentivirus relationship can be considered as an interplay of cellular and viral proteins, particularly apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) and viral infectivity factor (Vif). APOBEC3s enzymatically restrict lentivirus replication, whereas Vif antagonizes the host anti-viral action mediated by APOBEC3. In this study, the focus was on the interplay between feline APOBEC3 proteins and two feline immunodeficiency viruses in cats and pumas. To our knowledge, this study provides the first evidence of non-primate lentiviral Vif being incapable of counteracting a natural host's anti-viral activity mediated via APOBEC3 protein.
authors.affiliation: Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, 6068507.
authors.forename: Rokusuke
authors.initials: R
authors.lastname: Yoshikawa
authors.affiliation: Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, 6068507.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakano
authors.affiliation: Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, 6068507.
authors.forename: Eri
authors.initials: E
authors.lastname: Yamada
authors.affiliation: Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, 6068507.|CREST, Japan Science and Technology Agency, Saitama, 3220012, Japan.
authors.forename: Taisuke
authors.initials: T
authors.lastname: Izumi
authors.affiliation: Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, 6068507.
authors.forename: Naoko
authors.initials: N
authors.lastname: Misawa
authors.affiliation: Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, 6068507.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Koyanagi
authors.affiliation: Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, 6068507.|CREST, Japan Science and Technology Agency, Saitama, 3220012, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Sato
mesh_terms: D000071478:APOBEC Deaminases; D000818:Animals; D002415:Cats; D003564:Cytidine Deaminase; D043525:Cytosine Deaminase / Q000235:genetics / Q000378:metabolism*; D019143:Evolution, Molecular; D016346:Gene Products, vif / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D016089:Immunodeficiency Virus, Feline / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D046011:Puma; D013045:Species Specificity; D014777:Virus Diseases / Q000662:veterinary; D014779:Virus Replication
chemical_list: D016346:Gene Products, vif; D043525:Cytosine Deaminase; D000071478:APOBEC Deaminases; C502889:APOBEC3 proteins, human; D003564:Cytidine Deaminase
keywords: apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3; feline immunodeficiency virus; lentivirus; viral infectivity factor