title: Glucose Sensing Using Functionalized Amorphous In-Ga-Zn-O Field-Effect Transistors.
abstract: Recent advances in glucose sensing have focused on the integration of sensors into contact lenses to allow noninvasive continuous glucose monitoring. Current technologies focus primarily on enzyme-based electrochemical sensing which requires multiple nontransparent electrodes to be integrated. Herein, we leverage amorphous indium gallium zinc oxide (IGZO) field-effect transistors (FETs), which have found use in a wide range of display applications and can be made fully transparent. Bottom-gated IGZO-FETs can have significant changes in electrical characteristics when the back-channel is exposed to different environments. We have functionalized the back-channel of IGZO-FETs with aminosilane groups that are cross-linked to glucose oxidase and have demonstrated that these devices have high sensitivity to changes in glucose concentrations. Glucose sensing occurs through the decrease in pH during glucose oxidation, which modulates the positive charge of the aminosilane groups attached to the IGZO surface. The change in charge affects the number of acceptor-like surface states which can deplete electron density in the n-type IGZO semiconductor. Increasing glucose concentrations leads to an increase in acceptor states and a decrease in drain-source conductance due to a positive shift in the turn-on voltage. The functionalized IGZO-FET devices are effective in minimizing detection of interfering compounds including acetaminophen and ascorbic acid. These studies suggest that IGZO FETs can be effective for monitoring glucose concentrations in a variety of environments, including those where fully transparent sensing elements may be of interest.
authors.affiliation: School of Chemical, Biological, and Environmental Engineering, Oregon State University , Corvallis, Oregon 97331, United States.
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Du
authors.affiliation: School of Chemical, Biological, and Environmental Engineering, Oregon State University , Corvallis, Oregon 97331, United States.|College of Science, Civil Aviation University of China , Tianjin 300300, China.
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Chemical, Biological, and Environmental Engineering, Oregon State University , Corvallis, Oregon 97331, United States.
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Motley
authors.affiliation: Hewlett-Packard Company , Corvallis, Oregon 97330, United States.
authors.forename: William F
authors.initials: WF
authors.lastname: Stickle
authors.affiliation: School of Chemical, Biological, and Environmental Engineering, Oregon State University , Corvallis, Oregon 97331, United States.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Herman
mesh_terms: D000082:Acetaminophen / Q000737:chemistry; D001205:Ascorbic Acid / Q000737:chemistry; D005708:Gallium; D005947:Glucose / Q000032:analysis*; D007204:Indium; D010087:Oxides; D014173:Transistors, Electronic; D015032:Zinc
chemical_list: D010087:Oxides; D007204:Indium; D000082:Acetaminophen; D005708:Gallium; D005947:Glucose; D015032:Zinc; D001205:Ascorbic Acid
keywords: back-channel surface functionalization; field-effect transistor; glucose sensor; transparent amorphous oxide semiconductor; type I diabetes