title: Vitamin D and functional arterial parameters in postmenopausal women with metabolic syndrome.
abstract: OBJECTIVE
  Our cross sectional study aimed to identify the relation between vitamin D level and functional arterial parameters in postmenopausal women with metabolic syndrome.
  
  
  METHODS
  100 postmenopausal women at age 50-65 with diagnosed metabolic syndrome were included in this study. Laboratory tests were performed to determine lipid profile, serum glucose, creatinine, C-reactive protein, serum levels of 25(OH) D, ionized calcium and urine albumin/creatinine ratio. Also non-invasive assessment of arterial function (arterial stiffness, flow-mediated dilatation and carotid artery ultrasound examinations) was performed.
  
  
  RESULTS
  The mean vitamin D blood concentration was 47.4±16.9nmol/l. The prevalence of modest insufficiency and deficiency of vitamin D was 62%. Vitamin D concentration in samples assembled from January to March was significantly lower than concentration levels from September to November. No significant relationship was observed between vitamin D and endothelial function, arterial stiffness, carotid intima-media thickness. Week negative correlation was stated between mean arterial pressure and 25(OH) D concentration (p=0.04). A positive correlation was found between high density lipoprotein cholesterol and vitamin 25(OH) D (r=0.3, p<0.05). No significant difference between 25(OH) D and other lipoproteins, calcium ions, glucose, albumin/creatinine ratio and C-reactive protein blood concentrations were found.
  
  
  CONCLUSIONS
  The prevalence of vitamin D deficiency in postmenopausal women with metabolic syndrome is high. No relation was found between vitamin D levels and parameters that indicate atherosclerotic vascular lesions. Nevertheless our study revealed the relation between concentrations of vitamin D and mean blood pressure and high density lipoprotein cholesterol.
authors.affiliation: Vilnius University Medical Faculty, Vilnius, Lithuania; State Research Institute for Inovative Medicine, Vilnius, Lithuania.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Dadonienė
authors.affiliation: Vilnius University Medical Faculty, Vilnius, Lithuania; Vilnius University Centre of Cardiology and Angiology, Vilnius, Lithuania; State Research Institute for Inovative Medicine, Vilnius, Lithuania. Electronic address: alma.cypiene@santa.lt.
authors.forename: Alma
authors.initials: A
authors.lastname: Čypienė
authors.affiliation: Vilnius University Medical Faculty, Vilnius, Lithuania; Vilnius University Centre of Cardiology and Angiology, Vilnius, Lithuania; State Research Institute for Inovative Medicine, Vilnius, Lithuania.
authors.forename: Egidija
authors.initials: E
authors.lastname: Rinkūnienė
authors.affiliation: Vilnius University Medical Faculty, Vilnius, Lithuania; Vilnius University Centre of Cardiology and Angiology, Vilnius, Lithuania.
authors.forename: Jolita
authors.initials: J
authors.lastname: Badarienė
authors.affiliation: Vilnius University Medical Faculty, Vilnius, Lithuania; Vilnius University Centre of Cardiology and Angiology, Vilnius, Lithuania; State Research Institute for Inovative Medicine, Vilnius, Lithuania.
authors.forename: Jelizaveta
authors.initials: J
authors.lastname: Burca
authors.affiliation: Vilnius University Medical Faculty, Vilnius, Lithuania.
authors.forename: Ieva
authors.initials: I
authors.lastname: Sakaitė
authors.affiliation: Vilnius University Medical Faculty, Vilnius, Lithuania.
authors.forename: Goda
authors.initials: G
authors.lastname: Kalinauskaitė
authors.affiliation: Vilnius University Medical Faculty, Vilnius, Lithuania.
authors.forename: Vaiva
authors.initials: V
authors.lastname: Kumpauskaitė
authors.affiliation: Vilnius University Medical Faculty, Vilnius, Lithuania; Vilnius University Centre of Cardiology and Angiology, Vilnius, Lithuania; State Research Institute for Inovative Medicine, Vilnius, Lithuania.
authors.forename: Aleksandras
authors.initials: A
authors.lastname: Laucevičius
mesh_terms: D000368:Aged; D001158:Arteries / Q000503:physiopathology*; D001794:Blood Pressure; D003710:Demography; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood* / Q000503:physiopathology*; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D012621:Seasons; D014807:Vitamin D / Q000097:blood*
chemical_list: D014807:Vitamin D
keywords: Endothelial function; Metabolic syndrome; Vitamin D