title: [Immunohistochemical investigations on pulmonary tissue in cases of sudden infant death syndrome (SIDS)].
abstract: Numerous theories on the pathomechanism of SIDS favor a multifactorial genesis whereby infections of the upper respiratory tract and the pulmonary tissue have a trigger function. The aim of the presented study was to prove the presence of inflammatory responses in pulmonary tissue in SIDS cases because various studies revealed contradictory results about the evidence of inflammatory pulmonary responses in SIDS cases. For this purpose, 10 cases with defined causes of death were examined in comparison to 75 cases of sudden infant death syndrome (SIDS) with regard to CD45RO, CD68 and LCA positive cells in pulmonary tissue. Furthermore, the cell adhesion molecules E-selectin, P-selectin and VCAM were investigated. In the study group, the immunohistochemical imaging of CD45RO and LCA positive cells showed mostly negative results. There were no significant differences between study and control group as to the number of cells expressing CD45R0, CD68 and LCA. The same was true for the adhesion molecules E-selectin, P-selectin and VCAM.
authors.forename: Elke
authors.initials: E
authors.lastname: Doberentz
authors.forename: Younis
authors.initials: Y
authors.lastname: Albalooshi
authors.forename: Burkhard
authors.initials: B
authors.lastname: Madea
mesh_terms: D001344:Autopsy; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D005260:Female; D005858:Germany; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D007962:Leukocytes / Q000473:pathology; D008168:Lung / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D009000:Monocytes / Q000473:pathology; D013398:Sudden Infant Death / Q000473:pathology*
chemical_list: D015415:Biomarkers