title: Regulation of Growth Hormone by the Splanchnic Area.
abstract: The regulation of growth hormone (GH) was traditionally thought to be under the control of two main hypothalamic neuropeptides; GH-releasing hormone and somatostatin. In 1999, with the isolation of ghrelin, as a gastric-derived peptide with potent GH-releasing activity, concept of regulation of the somatotropic axis completely changed. In addition to its GH-releasing activity, ghrelin exhibited the capacity to modulate food intake and body weight. The role of this splanchnic factor in regulating GH as a nexus of energy balance control and GH are explored in this chapter. From a physiological standpoint, a novel mechanism of GH regulation mediated by ghrelin exists, implicating the peripheral modulation of the cannabinoid receptor.
authors.affiliation: Grupo Fisiopatología Endocrina, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain; Pediatric Department, Universidade de Santiago de Compostela, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain; CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Barja-Fernandez
authors.affiliation: Grupo Fisiopatología Endocrina, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain; CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Spain.
authors.forename: Cintia
authors.initials: C
authors.lastname: Folgueira
authors.affiliation: Grupo Fisiopatología Endocrina, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain; CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Spain.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Castelao
authors.affiliation: Pediatric Department, Universidade de Santiago de Compostela, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain.
authors.forename: Rosaura
authors.initials: R
authors.lastname: Leis
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Spain; Laboratorio de Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela, Spain.
authors.forename: Ana B
authors.initials: AB
authors.lastname: Crujeiras
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Spain; Laboratorio de Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela, Spain.
authors.forename: Felipe F
authors.initials: FF
authors.lastname: Casanueva
authors.affiliation: Grupo Fisiopatología Endocrina, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain; Pediatric Department, Universidade de Santiago de Compostela, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain. Electronic address: luisamaria.seoane@usc.es.
authors.forename: Luisa M
authors.initials: LM
authors.lastname: Seoane
mesh_terms: D000818:Animals; D002186:Cannabinoids / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism; D054439:Ghrelin / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D009752:Nutritional Status; D013152:Splanchnic Circulation
chemical_list: D002186:Cannabinoids; D054439:Ghrelin; D013006:Growth Hormone
keywords: GH; cannabinoid; ghrelin; stomach