title: Yttrium-90 hepatic radioembolization: clinical review and current techniques in interventional radiology and personalized dosimetry.
abstract: In recent years, yttrium-90 ((90)Y) microsphere radioembolization has been establishing itself as a safe and efficacious treatment for both primary and metastatic liver cancers. This extends to both first-line therapies as well as in the salvage setting. In addition, radioembolization appears efficacious for patients with portal vein thrombosis, which is currently a contraindication for surgery, transplantation and transarterial chemoembolization. This article reviews the efficacy and expanding use of (90)Y microsphere radioembolization with an added emphasis on recent advances in personalized dosimetry and interventional radiology techniques. Directions for future research into combination therapies with radioembolization and expansion into sites other than the liver are also explored.
authors.affiliation: 1 Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.
authors.forename: Aaron K T
authors.initials: AK
authors.lastname: Tong
authors.affiliation: 2 Department of Nuclear Medicine, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
authors.forename: Yung Hsiang
authors.initials: YH
authors.lastname: Kao
authors.affiliation: 3 Department of Diagnostic Radiology, Singapore General Hospital, Singapore.
authors.forename: Chow Wei
authors.initials: CW
authors.lastname: Too
authors.affiliation: 4 Duke-NUS Graduate Medical School, Singapore.
authors.forename: Kenneth F W
authors.initials: KF
authors.lastname: Chin
authors.affiliation: 1 Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.
authors.forename: David C E
authors.initials: DC
authors.lastname: Ng
authors.affiliation: 5 Department of Hepato-Pancreato-Biliary (HPB) and Transplant Surgery, Singapore General Hospital Surgical Oncology, National Cancer Centre, Singapore.
authors.forename: Pierce K H
authors.initials: PK
authors.lastname: Chow
mesh_terms: D019317:Evidence-Based Medicine; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D057285:Precision Medicine / Q000379:methods; D015641:Radiography, Interventional / Q000639:trends*; D011874:Radiometry / Q000639:trends*; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D061089:Radiotherapy, Image-Guided / Q000639:trends*; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes