title: Neurobiology ofCaenorhabditis elegansLocomotion: Where Do We Stand?
abstract: Animals use a nervous system for locomotion in some stage of their life cycle. The nematode Caenorhabditis elegans, a major animal model for almost all fields of experimental biology, has long been used for detailed studies of genetic and physiological locomotion mechanisms. Of its 959 somatic cells, 302 are neurons that are identifiable by lineage, location, morphology, and neurochemistry in every adult hermaphrodite. Of those, 75 motoneurons innervate body wall muscles that provide the thrust during locomotion. In this Overview, we concentrate on the generation of either forward- or backward-directed motion during crawling and swimming. We describe locomotion behavior, the parts constituting the locomotion system, and the relevant neuronal connectivity. Because it is not yet fully understood how these components combine to generate locomotion, we discuss competing hypotheses and models.
authors.affiliation: Julijana Gjorgjieva is a postdoctoral research fellow at the Center for Brain Science of Harvard University, in Cambridge, Massachusetts. She uses theoretical and numerical tools to understand how developing neural circuits wire to perform a particular function, from the mammalian visual system to the motor system of small invertebrates. David Biron is a physicist at the University of Chicago, Illinois. He studies the sleep of the roundworm Caenorhabditis elegans and related problems in biological physics. Gal Haspel ( haspel@njit.edu ) is a neuroethologist at the New Jersey Institute of Technology, in Newark. He studies the activity, connectivity and recovery from injury of the neuronal network that underlie locomotion in the nematode Caenorhabditis elegans.
authors.forename: Julijana
authors.initials: J
authors.lastname: Gjorgjieva
authors.affiliation: Julijana Gjorgjieva is a postdoctoral research fellow at the Center for Brain Science of Harvard University, in Cambridge, Massachusetts. She uses theoretical and numerical tools to understand how developing neural circuits wire to perform a particular function, from the mammalian visual system to the motor system of small invertebrates. David Biron is a physicist at the University of Chicago, Illinois. He studies the sleep of the roundworm Caenorhabditis elegans and related problems in biological physics. Gal Haspel ( haspel@njit.edu ) is a neuroethologist at the New Jersey Institute of Technology, in Newark. He studies the activity, connectivity and recovery from injury of the neuronal network that underlie locomotion in the nematode Caenorhabditis elegans.
authors.forename: David
authors.initials: D
authors.lastname: Biron
authors.affiliation: Julijana Gjorgjieva is a postdoctoral research fellow at the Center for Brain Science of Harvard University, in Cambridge, Massachusetts. She uses theoretical and numerical tools to understand how developing neural circuits wire to perform a particular function, from the mammalian visual system to the motor system of small invertebrates. David Biron is a physicist at the University of Chicago, Illinois. He studies the sleep of the roundworm Caenorhabditis elegans and related problems in biological physics. Gal Haspel ( haspel@njit.edu ) is a neuroethologist at the New Jersey Institute of Technology, in Newark. He studies the activity, connectivity and recovery from injury of the neuronal network that underlie locomotion in the nematode Caenorhabditis elegans.
authors.forename: Gal
authors.initials: G
authors.lastname: Haspel
keywords: Caenorhabditis elegans; animal behavior; locomotion; neurobiology