title: Patients with Rosacea Have Increased Risk of Depression and Anxiety Disorders: A Danish Nationwide Cohort Study.
abstract: BACKGROUND
  Rosacea is a chronic skin condition that affects self-esteem and quality of life. However, data on depression and anxiety in patients with rosacea are scarce.
  
  
  OBJECTIVE
  The aim of this study was to investigate the relationship between rosacea and new-onset depression and anxiety disorders.
  
  
  METHODS
  Data on all Danish citizens aged ≥18 years between January 1, 1997, and December 31, 2011, were linked at individual level in nationwide registers. Incidence rates per 1,000 person-years were calculated, and crude and adjusted incidence rate ratios (IRRs) with 95% confidence intervals (95% CIs) were estimated by Poisson regression models.
  
  
  RESULTS
  The study comprised a total of 4,632,341 individuals, including 30,725 and 24,712 patients with mild and moderate-to-severe rosacea, respectively. Mild and moderate-to-severe rosacea increased the risk of both depression [IRR 1.89 (95% CI 1.82-1.96) and IRR 2.04 (95% CI 1.96-2.12)] and anxiety disorders [IRR 1.80 (95% CI 1.75-1.86) and IRR 1.98 (95% CI 1.91-2.05)].
  
  
  CONCLUSIONS
  Rosacea was associated with a disease severity-dependent, increased risk of depression and anxiety disorders. The findings may call for increased awareness of psychiatric morbidity in patients with rosacea.
authors.affiliation: National Allergy Research Centre, Department of Dermato-Allergology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
authors.forename: Alexander
authors.initials: A
authors.lastname: Egeberg
authors.forename: Peter Riis
authors.initials: PR
authors.lastname: Hansen
authors.forename: Gunnar Hilmar
authors.initials: GH
authors.lastname: Gislason
authors.forename: Jacob Pontoppidan
authors.initials: JP
authors.lastname: Thyssen
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000453:epidemiology*; D016022:Case-Control Studies; D003718:Denmark / Q000453:epidemiology; D003863:Depression / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012393:Rosacea / Q000453:epidemiology / Q000523:psychology*; D012720:Severity of Illness Index; D055815:Young Adult