title: The functional connectivity in the motor loop of human basal ganglia.
abstract: Basal ganglia interact in a complex way which is still not completely understood. The model generally used to explain basal ganglia interactions is based on experimental data in animals, but its validation in humans has been hampered by methodological restrictions. The time-relationship (partial correlation) of the fluctuations of the blood-oxygen-level-dependent signals recorded in the main basal ganglia was used here (32 healthy volunteers; 18-72 years of age; 16 males and 16 females) to test whether the interaction of the main basal ganglia in humans follows the pattern of functional connectivity in animals. Data showed that most basal ganglia have a functional connectivity which is compatible with that of the established closed-loop model. The strength of the connectivity of some basal ganglia changed with finger motion, suggesting that the functional interactions between basal ganglia are quickly restructured by the motor tasks. The present study with the motor cortico-BG loop centers supports the circling dynamic of the basal ganglia model in humans, showing that motor tasks may change the functional connectivity of these centers.
authors.affiliation: Laboratory of Neurobiology and Experimental Neurology, Department of Physiology; Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.|Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: Rodriguez-Sabate
authors.affiliation: Department of Pharmacology and Physical Medicine, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.|Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Sabate
authors.affiliation: Department of Pharmacology and Physical Medicine, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: Catalina
authors.initials: C
authors.lastname: Llanos
authors.affiliation: Laboratory of Neurobiology and Experimental Neurology, Department of Physiology; Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.|Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Morales
authors.affiliation: Laboratory of Neurobiology and Experimental Neurology, Department of Physiology; Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.|Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Sanchez
authors.affiliation: Laboratory of Neurobiology and Experimental Neurology, Department of Physiology; Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain. mrdiaz@ull.es.|Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. mrdiaz@ull.es.
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodriguez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001479:Basal Ganglia / Q000502:physiology*; D003198:Computer Simulation; D063132:Connectome / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology*; D055815:Young Adult
keywords: Basal ganglia; Cerebral cortex; Functional connectivity; Hand motion; Resting state