title: Testing for association between RNA-Seq and high-dimensional data.
abstract: BACKGROUND
  Testing for association between RNA-Seq and other genomic data is challenging due to high variability of the former and high dimensionality of the latter.
  
  
  RESULTS
  Using the negative binomial distribution and a random-effects model, we develop an omnibus test that overcomes both difficulties. It may be conceptualised as a test of overall significance in regression analysis, where the response variable is overdispersed and the number of explanatory variables exceeds the sample size.
  
  
  CONCLUSIONS
  The proposed test can detect genetic and epigenetic alterations that affect gene expression. It can examine complex regulatory mechanisms of gene expression. The R package globalSeq is available from Bioconductor.
authors.affiliation: Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007, MB, The Netherlands. a.rauschenberger@vumc.nl.
authors.forename: Armin
authors.initials: A
authors.lastname: Rauschenberger
authors.affiliation: Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007, MB, The Netherlands. m.jonker2@vumc.nl.
authors.forename: Marianne A
authors.initials: MA
authors.lastname: Jonker
authors.affiliation: Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007, MB, The Netherlands. mark.vdwiel@vumc.nl.|Department of Mathematics, VU University, Amsterdam, 1081, HV, The Netherlands. mark.vdwiel@vumc.nl.
authors.forename: Mark A
authors.initials: MA
authors.lastname: van de Wiel
authors.affiliation: Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007, MB, The Netherlands. r.menezes@vumc.nl.
authors.forename: Renée X
authors.initials: RX
authors.lastname: Menezes
mesh_terms: D000465:Algorithms; D020869:Gene Expression Profiling; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics*; D012313:RNA / Q000235:genetics*; D012044:Regression Analysis; D017423:Sequence Analysis, RNA / Q000379:methods*
chemical_list: D012313:RNA