title: Pregabalin in Chemotherapy Induced Neuropathic Pain.
abstract: Chemotherapeutic agents belonging to vinca alkaloids, taxanes, and antitubulins produce peripheral neuropathy for which there is no validated treatment. Pregabalin, a gamma-aminobutyric acid analog, is known to inhibit theα2δ subunit of the voltage-gated calcium channel. Earlier studies and case reports have shown pregabalin to be effective in treating neuropathic pain. We present a case series of patients with chemotherapy-induced peripheral neuropathy who were successfully treated with pregabalin with reduction in the hyperalgesia, allodynia, and improvement in the quality of life.
authors.affiliation: Department of Palliative Care and Psychooncology, Tata Medical Center, Kolkata, West Bengal, India.
authors.forename: Shrikant
authors.initials: S
authors.lastname: Atreya
keywords: Cancer; Chemotherapy-induced peripheral neuropathy; Pregabalin