title: Catalog of genetic progression of human cancers: non-Hodgkin lymphoma.
abstract: The recent application of next-generation sequencing technologies lead to significant improvements in our understanding of genetic underpinnings of non-Hodgkin lymphomas with identification of an unexpectedly high number of novel mutation targets across the different B-cell lymphoma entities. These recently discovered molecular lesions are expected to have a major impact on development of novel biomarkers and targeted therapies as well as patient stratification based on the underlying genetic profile. This review will cover the major discoveries in B-cell lymphomas using next-generation sequencing technologies over the last few years, highlighting alterations associated with relapse and progression of these diseases.
authors.affiliation: MTA-SE Lendulet Molecular Oncohematology Research Group, Budapest, Hungary.|1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Bödör
authors.affiliation: 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary. reiniger.lilla@med.semmelweis-univ.hu.|2nd Department of Pathology, MTA-SE NAP, Brain Metastasis Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary. reiniger.lilla@med.semmelweis-univ.hu.
authors.forename: Lilla
authors.initials: L
authors.lastname: Reiniger
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D018450:Disease Progression; D019143:Evolution, Molecular; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000235:genetics* / Q000473:pathology; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics
chemical_list: D009363:Neoplasm Proteins
keywords: Clonal evolution; Next-generation sequencing; Non-Hodgkin lymphoma