title: Decorated self-assembling β(3)-tripeptide foldamers form cell adhesive scaffolds.
abstract: A popular strategy to control cellular growth and differentiation is the employment of self-assembling peptides as biomaterials. In this study we decorated ultrashort helical N-acetylated β-tripeptides with cell adhesion signals IKVAV and RGD, which spontaneously self-assemble to give nanofibres with multiple signals, and form a bioscaffold that supports the growth of cells.
authors.affiliation: Department of Biochemistry & Molecular Biology, Monash University, Clayton, VIC, Australia. mark.delborgo@monash.edu mibel.aguilar@monash.edu.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Luder
authors.affiliation: Department of Biochemistry & Molecular Biology, Monash University, Clayton, VIC, Australia. mark.delborgo@monash.edu mibel.aguilar@monash.edu.
authors.forename: Ketav
authors.initials: K
authors.lastname: Kulkarni
authors.affiliation: Department of Pharmacology, Monash University, Wellington Rd, Clayton, VIC 3800, Australia.
authors.forename: Huey Wen
authors.initials: HW
authors.lastname: Lee
authors.affiliation: Department of Pharmacology, Monash University, Wellington Rd, Clayton, VIC 3800, Australia.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Widdop
authors.affiliation: Department of Biochemistry & Molecular Biology, Monash University, Clayton, VIC, Australia. mark.delborgo@monash.edu mibel.aguilar@monash.edu.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Del Borgo
authors.affiliation: Department of Biochemistry & Molecular Biology, Monash University, Clayton, VIC, Australia. mark.delborgo@monash.edu mibel.aguilar@monash.edu.
authors.forename: Marie-Isabel
authors.initials: MI
authors.lastname: Aguilar
mesh_terms: D002448:Cell Adhesion; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D009842:Oligopeptides / Q000737:chemistry*; D017510:Protein Folding; D054457:Tissue Scaffolds
chemical_list: D009842:Oligopeptides