title: A Facile Strategy to Prepare Dendrimer-stabilized Gold Nanorods with Sub-10-nm Size for Efficient Photothermal Cancer Therapy.
abstract: Gold (Au) nanoparticles are promising photothermal agents with the potential of clinical translation. However, the safety concerns of Au photothermal agents including the potential toxic compositions such as silver and copper elements in their structures and the relative large size-caused retention and accumulation in the body post-treatment are still questionable. In this article, we successfully synthesized dendrimer-stabilized Au nanorods (DSAuNRs) with pure Au composition and a sub-10-nm size in length, which represented much higher photothermal effect compared with dendrimer-encapsulated Au nanoparticles due to their significantly enhanced absorption in the near-infrared region. Furthermore, glycidol-modified DSAuNRs exhibited the excellent biocompatibility and further showed the high photothermal efficiency of killing cancer cells in vitro and retarding tumor growth in vivo. The investigation depicted an optimal photothermal agent with the desirable size and safe composition.
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life sciences, East China Normal University, Shanghai, 200241, P.R. China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life sciences, East China Normal University, Shanghai, 200241, P.R. China.
authors.forename: Hanling
authors.initials: H
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life sciences, East China Normal University, Shanghai, 200241, P.R. China.
authors.forename: Yitong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai, 200241, P.R. China.
authors.forename: Xiangtong
authors.initials: X
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai, 200241, P.R. China.
authors.forename: Sanjun
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life sciences, East China Normal University, Shanghai, 200241, P.R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life sciences, East China Normal University, Shanghai, 200241, P.R. China.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D050091:Dendrimers / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D008297:Male; D008807:Mice, Inbred BALB C; D043942:Nanotubes / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D010789:Phototherapy / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; C104700:PAMAM Starburst