title: Peptide [4]Catenane by Folding and Assembly.
abstract: A topologically complex peptide [4]catenane with the crossing number of 12 was synthesized by a folding and assembly strategy wherein the folding and metal-directed self-assembly of a short peptide fragment occur simultaneously. The latent Ω-looped conformation of the Pro-Gly-Pro sequence was found only when pyridines at the C- and N-termini coordinatively bind metal ions (Ag(I) or Au(I) ). Crystallographic studies revealed that the Ω-looped motifs formed four M3 L3 macrocycles that were intermolecularly entwined to generate an unprecedented peptide [4]catenane topology.
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. tsawada@appchem.t.u-tokyo.ac.jp.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Sawada
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Motoya
authors.initials: M
authors.lastname: Yamagami
authors.affiliation: Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa, 769-2193, Japan.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ohara
authors.affiliation: Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa, 769-2193, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yamaguchi
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. mfujita@appchem.t.u-tokyo.ac.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Fujita
mesh_terms: D000873:Anthracenes / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry*; D017510:Protein Folding
chemical_list: D000873:Anthracenes; D010455:Peptides; C467767:catenane
keywords: macrocycles; peptides; self-assembly; silver; structure elucidation