title: Membrane Dynamics and Signaling of the Coxsackievirus and Adenovirus Receptor.
abstract: The coxsackievirus and adenovirus receptor (CAR) belongs to the immunoglobulin superfamily and acts as a receptor for some adenovirus types and group B coxsackieviruses. Its role is best described in epithelia where CAR participates to tight junction integrity and maintenance. Recently, several studies aimed to characterize its potential interaction with intracellular signaling pathways and highlighted several features linking CAR to gene expression. In addition, the molecular mechanisms leading to CAR-specific membrane targeting via the secretory pathway in polarized cells and its internalization are starting to be unraveled. This chapter discusses the interaction between membrane dynamics, intracellular trafficking, and signaling of CAR.
authors.affiliation: Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, Montpellier, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Loustalot
authors.affiliation: Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, Montpellier, France. Electronic address: eric.kremer@igmm.cnrs.fr.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Kremer
authors.affiliation: Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, Montpellier, France. Electronic address: sara.salinas@inserm.fr.
authors.forename: Sara
authors.initials: S
authors.lastname: Salinas
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D021381:Protein Transport / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D019108:Tight Junctions / Q000378:metabolism*
chemical_list: D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein
keywords: cellular signaling; coxsackievirus and adenovirus receptor (CAR); membrane dynamics; protein trafficking