title: Deficits in coordinated motor behavior and in nigrostriatal dopaminergic system ameliorated and VMAT2 expression up-regulated in aged male rats by administration of testosterone propionate.
abstract: The effects of testosterone propionate (TP) supplements on the coordinated motor behavior and nigrostriatal dopaminergic (NSDA) system were analyzed in aged male rats. The present study showed the coordinated motor behavioral deficits, the reduced activity of NSDA system and the decreased expression of vesicular monoamine transporter 2 (VMAT2) in 24 month-old male rats. Long term TP treatment improved the motor coordination dysfunction with aging. Increased tyrosine hydroxylase and dopamine transporter, as well as dopamine and its metabolites were found in the NSDA system of TP-treated 24 month-old male rats, indicative of the amelioratory effects of TP supplements on NSDA system of aged male rats. The enhancement of dopaminergic (DAergic) activity of NSDA system by TP supplements might underlie the amelioration of the coordinated motor dysfunction in aged male rats. TP supplements up-regulated VMAT2 expression in NSDA system of aged male rats. Up-regulation of VMAT2 expression in aged male rats following chronic TP treatment might be involved in the maintenance of DAergic function of NSDA system in aged male rats.
authors.affiliation: Department of Neurobiology, Hebei Medical University, Shijiazhuang 050017, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Neurobiology, Hebei Medical University, Shijiazhuang 050017, PR China.
authors.forename: Yunxiao
authors.initials: Y
authors.lastname: Kang
authors.affiliation: Department of Neurobiology, Hebei Medical University, Shijiazhuang 050017, PR China; Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, PR China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Neurobiology, Hebei Medical University, Shijiazhuang 050017, PR China.
authors.forename: Yingbo
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Cui
authors.affiliation: Department of Neurobiology, Hebei Medical University, Shijiazhuang 050017, PR China.
authors.forename: Wensheng
authors.initials: W
authors.lastname: Yan
authors.affiliation: Department of Anatomy, Liaoning Medical College, Jinzhou, PR China.
authors.forename: Huibing
authors.initials: H
authors.lastname: Tan
authors.affiliation: Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, PR China.
authors.forename: Shuangcheng
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Anatomy, Liaoning Medical College, Jinzhou, PR China.
authors.forename: Baiyila
authors.initials: B
authors.lastname: Wu
authors.affiliation: Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, PR China.
authors.forename: Huixian
authors.initials: H
authors.lastname: Cui
authors.affiliation: Department of Neurobiology, Hebei Medical University, Shijiazhuang 050017, PR China. Electronic address: shigeming@163.com.
authors.forename: Geming
authors.initials: G
authors.lastname: Shi
mesh_terms: D000375:Aging; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000187:drug effects*; D043343:Testosterone Propionate / Q000494:pharmacology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D015854:Up-Regulation; D050493:Vesicular Monoamine Transport Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; C493454:Slc18a2 protein, rat; D050493:Vesicular Monoamine Transport Proteins; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine; D043343:Testosterone Propionate
keywords: Aged male rats; Coordinated motor behavior; Nigrostriatal dopaminergic system; Testosterone propionate; Vesicular monoamine transporter 2