title: Combined effects of engineered tendon matrix and GDF-6 on bone marrow mesenchymal stem cell-based tendon regeneration.
abstract: OBJECTIVE
  To examine whether an engineered tendon matrix (ETM) environment and growth and differentiation factor-6 (GDF-6) have synergistic effects on the tenogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and the quality of tendon repair.
  
  
  RESULTS
  ETM and GDF-6 promote tenogenic differentiation of BMSCs in vitro. Implantation of GDF-6-incorporated ETM containing BMSCs into a tendon injury model significantly improved the histological and mechanical properties of the repaired tendon.
  
  
  CONCLUSIONS
  GDF-6-incorporated ETM containing BMSCs represents a promising strategy for tendon injury repair.
authors.affiliation: Department of Pediatric Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 KongJiang Road, Shanghai, 200092, China. jdp509@163.com.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Jiang
authors.affiliation: Department of Pediatric Surgery, Harbin Children Hospital, Harbin, 150086, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Gao
authors.affiliation: Department of Pediatric Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 KongJiang Road, Shanghai, 200092, China.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pediatric Surgery, Harbin Children Hospital, Harbin, 150086, China.
authors.forename: Shulong
authors.initials: S
authors.lastname: Yang
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D005109:Extracellular Matrix / Q000378:metabolism*; D055431:Growth Differentiation Factor 6 / Q000378:metabolism*; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D009924:Organ Culture Techniques; D011817:Rabbits; D051381:Rats; D012038:Regeneration; D013710:Tendons / Q000502:physiology*
chemical_list: D055431:Growth Differentiation Factor 6
keywords: Bone marrow mesenchymal stem cells; Differentiation; Extracellular matrix; Growth and differentiation factor; Stem cells (bone marrow); Tendon matrix