title: Altered Amygdala Resting-State Functional Connectivity in Maintenance Hemodialysis End-Stage Renal Disease Patients with Depressive Mood.
abstract: The purpose of this study was to investigate patterns in the amygdala-based emotional processing circuit of hemodialysis patients using resting-state functional MR imaging (rs-fMRI). Fifty hemodialysis patients (25 with depressed mood and 25 without depressed mood) and 26 healthy controls were included. All subjects underwent neuropsychological tests and rs-fMRI, and patients also underwent laboratory tests. Functional connectivity of the bilateral amygdala was compared among the three groups. The relationship between functional connectivity and clinical markers was investigated. Depressed patients showed increased positive functional connectivity of the left amygdala with the left superior temporal gyrus and right parahippocampal gyrus (PHG) but decreased amygdala functional connectivity with the left precuneus, angular gyrus, posterior cingulate cortex (PCC), and left inferior parietal lobule compared with non-depressed patients (P < 0.05, AlphaSim corrected). Depressed patients had increased positive functional connectivity of the right amygdala with bilateral supplementary motor areas and PHG but decreased amygdala functional connectivity with the right superior frontal gyrus, superior parietal lobule, bilateral precuneus, and PCC (P < 0.05, AlphaSim corrected). After including anxiety as a covariate, we discovered additional decreased functional connectivity with anterior cingulate cortex (ACC) for bilateral amygdala (P < 0.05, AlphaSim corrected). For the depressed, neuropsychological test scores were correlated with functional connectivity of multiple regions (P < 0.05, AlphaSim corrected). In conclusion, functional connectivity in the amygdala-prefrontal-PCC-limbic circuits was impaired in depressive hemodialysis patients, with a gradual decrease in ACC between controls, non-depressed, and depressed patients for the right amygdala. This indicates that ACC plays a role in amygdala-based emotional regulatory circuits in these patients.
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 210002, China.
authors.forename: Hui Juan
authors.initials: HJ
authors.lastname: Chen
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 210002, China.
authors.forename: Yun Fei
authors.initials: YF
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 210002, China.
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Qi
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 210002, China.|Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, MSC 226, 25 Courtenay Dr, Charleston, SC, 29401, USA.
authors.forename: U Joseph
authors.initials: UJ
authors.lastname: Schoepf
authors.affiliation: Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, MSC 226, 25 Courtenay Dr, Charleston, SC, 29401, USA.
authors.forename: Akos
authors.initials: A
authors.lastname: Varga-Szemes
authors.affiliation: Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, MSC 226, 25 Courtenay Dr, Charleston, SC, 29401, USA.
authors.forename: B Devon
authors.initials: BD
authors.lastname: Ball
authors.affiliation: National Clinical Research Center of Kidney Disease, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 210002, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Kong
authors.affiliation: National Clinical Research Center of Kidney Disease, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China.
authors.forename: Jiqiu
authors.initials: J
authors.lastname: Wen
authors.affiliation: National Clinical Research Center of Kidney Disease, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 210002, China.
authors.forename: Guang Ming
authors.initials: GM
authors.lastname: Lu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 210002, China. kevinzhlj@163.com.
authors.forename: Long Jiang
authors.identifier: 0000-0002-6664-7224
authors.initials: LJ
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000503:physiopathology*; D001931:Brain Mapping; D003863:Depression / Q000523:psychology*; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000523:psychology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D006435:Renal Dialysis / Q000379:methods; D055815:Young Adult
keywords: Amygdala; End-stage renal disease; Hemodialysis; Magnetic resonance imaging; Resting-state functional connectivity