title: Rhodium- and Iridium-Catalyzed Asymmetric Addition of Optically Pure P-Chiral H-Phosphinates to Aldehydes Leading to Optically Active α-Hydroxyphosphinates.
abstract: Optically active α-hydroxyphosphinates with both C- and P-stereogenic centers are obtained by rhodium- or iridium-catalyzed substrate-directed stereoselective addition of the optically pure H-phosphinates to aldehydes. The reaction most probably proceeds by a transition-metal-catalyzed mechanism with hydridometal complexes as key intermediates in the catalytic cycle.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, 410081, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, 410081, China.
authors.forename: Tieqiao
authors.initials: T
authors.lastname: Chen
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang, 325035, China. qing-xu@wzu.edu.cn.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
authors.affiliation: National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, 305-8565, Japan. libiao-han@aist.go.jp.
authors.forename: Li-Biao
authors.initials: LB
authors.lastname: Han
keywords: aldehydes; hydroxyphosphinates; iridium catalyst; phosphinates; rhodium catalyst; stereoselective addition