title: Cabergoline in the Treatment of Male Orgasmic Disorder-A Retrospective Pilot Analysis.
abstract: BACKGROUND
  Male orgasmic disorder is common, with few treatment options. Cabergoline is a dopamine agonist that acts centrally to normalize serum prolactin that could improve orgasmic dysfunction.
  
  
  OBJECTIVE
  To determine whether cabergoline increases the potential for orgasm in men with orgasmic disorder.
  
  
  METHODS
  A retrospective chart review of men treated in a single andrology clinic for delayed orgasm or anorgasmia in a pilot study using cabergoline 0.5 mg twice weekly was performed. Duration of treatment and response were noted. Medical records were examined for other factors including history of prostatectomy and concomitant androgen supplementation.
  
  
  METHODS
  Subjective improvement in orgasmic function resulting from cabergoline treatment.
  
  
  RESULTS
  Of 131 men treated with cabergoline for orgasmic disorder, 87 (66.4%) reported subjective improvement in orgasm and 44 (33.6%) reported no change in orgasm. Duration of therapy (P = .03) and concomitant testosterone therapy (P = .02) were associated with a significant positive response to cabergoline treatment. No differences were found between injectable and non-injectable testosterone formulations (P = .90), and neither age (P = .90) nor prior prostatectomy (P = .41) influenced the outcome of cabergoline treatment. Serum testosterone levels before (P = .26) and after (P = .81) treatment were not significantly different in responders vs non-responders.
  
  
  CONCLUSIONS
  Cabergoline is a potentially effective and easy-to-administer treatment for male orgasmic disorder, the efficacy of which appears to be independent of patient age or orgasmic disorder etiology. Prospective randomized trials are needed to determine the true role of cabergoline in the treatment of this disorder.
authors.affiliation: Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Adam B
authors.initials: AB
authors.lastname: Hollander
authors.affiliation: Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA; Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA. Electronic address: pastusza@bcm.edu.
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Pastuszak
authors.affiliation: Department of Urology, University of California-San Diego, San Diego, CA, USA.
authors.forename: Tung-Chin
authors.initials: TC
authors.lastname: Hsieh
authors.affiliation: Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: William G
authors.initials: WG
authors.lastname: Johnson
authors.affiliation: Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA; Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Scovell
authors.affiliation: Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Christina K
authors.initials: CK
authors.lastname: Mai
authors.affiliation: Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA; Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Larry I
authors.initials: LI
authors.lastname: Lipshultz
keywords: Anorgasmia; Cabergoline; Male Orgasmic Disorder; Orgasm