title: Subclinical arterial and cardiac damage in white-coat and masked hypertension.
abstract: The study aimed to compare arterial and echocardiographic parameters in subjects with newly diagnosed masked (MH) or white-coat hypertension (WCH) to subjects with sustained normotension or sustained hypertension, defined according to the 2014 European Society of Hypertension practice guidelines for ambulatory blood pressure (BP) monitoring. We recruited 303 participants (mean age 46.9 years) in a family-based population study. SpaceLabs monitors and oscillometric sphygmomanometers were used to evaluate ambulatory and office BP, respectively. Central pulse pressure (PP) and aortic pulse-wave velocity (PWV) were measured with pulse-wave analysis (SphygmoCor software). Carotid intima-media thickness (IMT) and cardiac evaluation were assessed by ultrasonography. Analysing participants without antihypertensive treatment (115 sustained normotensives, 41 sustained hypertensives, 20 with WCH, 25 with MH), we detected significantly higher peripheral and central PP, PWV, IMT and left ventricular mass index in hypertensive subgroups than in those with sustained normotension. The differences between categories remained significant for peripheral PP and PWV after adjustment for confounding factors, including 24 h systolic and diastolic BP. Participants with WCH and MH, defined according to strict criteria, had more pronounced arterial and heart involvement than normotensive participants. The study demonstrates a high prevalence of these conditions in the general population that deserves special attention from physicians.
authors.affiliation: a The First Department of Cardiology, Interventional Electrocardiology and Hypertension , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Wiktoria
authors.initials: W
authors.lastname: Wojciechowska
authors.affiliation: a The First Department of Cardiology, Interventional Electrocardiology and Hypertension , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Stolarz-Skrzypek
authors.affiliation: a The First Department of Cardiology, Interventional Electrocardiology and Hypertension , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Olszanecka
authors.affiliation: a The First Department of Cardiology, Interventional Electrocardiology and Hypertension , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Klima
authors.affiliation: b Department of Internal Medicine and Gerontology , Jagiellonian University Medical College , Kraków , Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Gąsowski
authors.affiliation: b Department of Internal Medicine and Gerontology , Jagiellonian University Medical College , Kraków , Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grodzicki
authors.affiliation: a The First Department of Cardiology, Interventional Electrocardiology and Hypertension , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Kalina
authors.initials: K
authors.lastname: Kawecka-Jaszcz
authors.affiliation: a The First Department of Cardiology, Interventional Electrocardiology and Hypertension , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Danuta
authors.initials: D
authors.lastname: Czarnecka
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001795:Blood Pressure Determination; D018660:Blood Pressure Monitoring, Ambulatory; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D004452:Echocardiography; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D059468:Masked Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008875:Middle Aged; D014463:Ultrasonography; D059289:Vascular Stiffness; D059466:White Coat Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology*
keywords: Ambulatory blood pressure monitoring; arterial stiffness; left ventricle diastolic dysfunction; left ventricular hypertrophy; masked hypertension; white-coat hypertension