title: Efficacy of Ablation Therapy for Secondary Hyperparathyroidism by Ultrasound Guided Percutaneous Thermoablation.
abstract: The objective of this study was to explore the value of ultrasound-guided percutaneous microwave thermoablation to treat secondary hyperparathyroidism (SHPT). One hundred and thirty-eight parathyroid glands from 56 patients with SHPT were ablated in this study. All the parathyroid glands were evaluated by real-time contrast-enhanced ultrasound before, during and after ablation. Changes in serum parathyroid hormone (sPTH) levels were measured before treatment and at 1 h, 1 wk, 1 mo and 6 mo after thermoablation treatment. All 56 cases had a 1-mo follow-up, and 34 cases had a 6-mo follow-up. The sPTH level of the 54 cases 1 mo after ablation was significantly lower than that before (p < 0.05). In the 34 cases that had a 6-mo follow-up, the sPTH levels were also significantly lower at 6 mo after ablation than before (p < 0.05). Bone pain in patients improved post-operatively (p < 0.05), but itchiness and insomnia did not improve (p > 0.05). Ultrasound-guided percutaneous microwave thermoablation is a feasible and effective non-surgical alternative treatment for SHPT patients.
authors.affiliation: Department of Ultrasound, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Ultrasound, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China. Electronic address: qianlinxue2002@163.com.
authors.forename: Linxue
authors.initials: L
authors.lastname: Qian
authors.affiliation: Department of Ultrasound, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zu
authors.affiliation: Department of Ultrasound, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Ultrasound, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Hu
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000000981:diagnostic imaging* / Q000628:therapy*; D006979:Hyperthermia, Induced / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids; D013459:Sulfur Hexafluoride; D025321:Surgery, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride
keywords: Secondary hyperparathyroidism; Serum parathyroid hormone; Thermal ablation; Ultrasound