title: High Mortality of Cirrhotic Patients With End-Stage Renal Disease.
abstract: Ascites, hepatic encephalopathy (HE), and esophageal variceal bleeding (EVB) are 3 major complications in patients with cirrhosis. Limited data exist with which to evaluate the long-term mortality of end-stage renal disease (ESRD) in cirrhotic patients with or without complications.The National Health Insurance Database in Taiwan was used to identify patients with cirrhosis hospitalized between January 1, 2007, and December 31, 2007. The study group consisted of 1068 cirrhotic patients with ESRD, and the control group consisted of 10,680 randomly selected cirrhotic patients without baseline renal function impairment.The overall 1-year and 3-year mortality rates were 48.5% and 73.1% in the ESRD group, and 32.9% and 55.6% in the control group, respectively. After adjusting for other comorbid disorders, the cirrhotic patients with ESRD showed a statistically significant increase in 3-year mortality (hazard ratio [HR], 1.65; P < 0.001). The HR for 3-year mortality of ESRD cirrhotic patients with recurrent complications was 1.98 (P < 0.001), compared to those with no recent or past complications. The HR of ESRD for 3-year mortality was 1.48 (P < 0.001) in cirrhotic patients with ascites, 1.67 (P < 0.001) in patients with EVB, and 1.19 (P = 0.147) in patients with HE.ESRD increases the mortality rate in patients with cirrhosis. Recurrent complications can account for a 2-fold increase in the 3-year mortality of ESRD cirrhotic patients. ESRD has a smaller impact on the 3-year mortality of cirrhotic patients with HE compared to those with ascites or EVB.
authors.affiliation: From the Division of Gastroenterology (T-HH, K-CT, C-WT, Y-HH, H-FL), Department of Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Foundation, Chia-Yi; School of Medicine (T-HH, C-CT, K-CT, C-WT, Y-HH, H-FL), Tzu Chi University, Hualien; Department of Mathematics (C-CT), Tamkang University, Tamsui; and Division of Infectious disease (C-CT), Department of Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Foundation, Chia-Yi, Taiwan.
authors.forename: Tsung-Hsing
authors.initials: TH
authors.lastname: Hung
authors.forename: Chen-Chi
authors.initials: CC
authors.lastname: Tsai
authors.forename: Kuo-Chih
authors.initials: KC
authors.lastname: Tseng
authors.forename: Chih -Wei
authors.initials: C-
authors.lastname: Tseng
authors.forename: Yu-Hsi
authors.initials: YH
authors.lastname: Hsieh
authors.forename: Chih-Chun
authors.initials: CC
authors.lastname: Tsai
authors.forename: Hsing-Feng
authors.initials: HF
authors.lastname: Lee
mesh_terms: D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000401:mortality*; D008103:Liver Cirrhosis / Q000150:complications / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013624:Taiwan / Q000453:epidemiology; D013997:Time Factors