title: Do biofilms confer a pro-carcinogenic state?
abstract: It is now widely recognized that a range of human diseases, including obesity, cancer and inflammatory bowel disease, is strongly linked to the microbiota. For decades, the microbiota has been proposed to contribute to the pathogenesis of colon cancer. Our recent work reveals that the organization of the mucosal microbiota into biofilms marks a subset of human colon cancer. Further, biofilm-positive colon mucosa in the colon cancer host yields an infrequently detected polyamine metabolite, N(1), N(12)-diacetylspermine, that deserves further study to determine its utility as a marker for colon neoplasia.
authors.affiliation: a Department of Oncology , Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions , Baltimore , MD , USA.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Dejea
authors.affiliation: a Department of Oncology , Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions , Baltimore , MD , USA.|b Department of Medicine , Johns Hopkins University School of Medicine, Johns Hopkins Medical Institutions , Baltimore , MD , USA.
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Sears
mesh_terms: D001427:Bacterial Toxins / Q000378:metabolism; D001441:Bacteroides fragilis / Q000472:pathogenicity; D018441:Biofilms; D003110:Colonic Neoplasms / Q000382:microbiology* / Q000473:pathology; D004926:Escherichia coli / Q000472:pathogenicity; D016967:Fusobacterium nucleatum / Q000472:pathogenicity; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology*; D008666:Metalloendopeptidases / Q000378:metabolism; D010455:Peptides / Q000378:metabolism; D061065:Polyketides / Q000378:metabolism; D013096:Spermine / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D001427:Bacterial Toxins; D010455:Peptides; D061065:Polyketides; C569566:colibactin; D013096:Spermine; C029453:N',N''-diacetylspermine; C405031:Bacteroides fragilis toxin; D008666:Metalloendopeptidases
keywords: bacteroides; biofilm; colorectal cancer; escherichia coli; fusobacterium; microbiome; screening colonoscopy