title: [Correlates of Cognitive Impairment of Rheumatic Disease: Systematic Review and Meta-analysis].
abstract: OBJECTIVE
  This study was conducted to synthesis the results of research on relationships of cognitive impairment with multi-dimensional correlates of rheumatic disease through a systematic literature review and meta-analysis.
  
  
  METHODS
  For the study purpose, 23 studies were selected through a systematic process of searching the literature.
  
  
  RESULTS
  The study results showed that among general characteristics, age and education were the variables having a significant relationship with cognitive impairment. Among health risk factors, obesity appeared to have a significant positive relationship with cognitive impairment. For past history, diabetes and hypertension were shown to have a significant positive relationship with cognitive impairment. It was noted also that aPL, one of the physiological factor, had significant association with cognitive impairment. None of the medication related factors had a significant relationship with cognitive impairment. Results showed that among disease related factors, disease activity had the highest relationship with cognitive impairment. Depression, among psychological factors, was the only variable having a significant relationship with cognitive impairment.
  
  
  CONCLUSIONS
  The findings indicate that the variables strongly impacting on cognitive impairment in rheumatic disease are depression and disease activity.
authors.affiliation: National Evidence-based Health Care Collaborating Agency, Seoul, Korea.
authors.forename: Jina
authors.initials: J
authors.lastname: Mo
authors.affiliation: Department of Nursing, Inha University Hospital, Incheon, Korea.
authors.forename: Jisuk
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Nursing, Inha University, Incheon, Korea. hsoh@inha.ac.kr.
authors.forename: Hyunsoo
authors.initials: H
authors.lastname: Oh
mesh_terms: D001007:Anxiety; D003071:Cognition; D003072:Cognition Disorders / Q000150:complications / Q000473:pathology*; D016208:Databases, Factual; D003863:Depression / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D009765:Obesity / Q000150:complications; D012216:Rheumatic Diseases / Q000150:complications / Q000473:pathology*; D012307:Risk Factors
keywords: Cognition disorders; Meta-analysis; Review; Rheumatic diseases