title: A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase.
abstract: Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.
authors.affiliation: Institute of Technical Biology and Agriculture Engineering, Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, P. R. China. zly0605@ustc.edu.cn.
authors.forename: Liyun
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543, Singapore and Graduate School for Integrative Sciences and Engineering, National University of Singapore, Centre for Life Sciences, #05-01, 28 Medical Drive, 117456 Singapore.
authors.forename: Jun Cheng
authors.initials: JC
authors.lastname: Er
authors.affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Institute of Technical Biology and Agriculture Engineering, Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, P. R. China. zly0605@ustc.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China.
authors.forename: Zhaofeng
authors.initials: Z
authors.lastname: Luo
authors.affiliation: MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, EH16 4TJ Edinburgh, UK. mvendrel@staffmail.ed.ac.uk.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ramezani
authors.affiliation: MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, EH16 4TJ Edinburgh, UK. mvendrel@staffmail.ed.ac.uk.
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543, Singapore.
authors.forename: Mui Kee
authors.initials: MK
authors.lastname: Tang
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543, Singapore.
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
authors.affiliation: MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, EH16 4TJ Edinburgh, UK. mvendrel@staffmail.ed.ac.uk.
authors.forename: Marc
authors.initials: M
authors.lastname: Vendrell
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry*; D057054:Molecular Imaging; D015394:Molecular Structure; D000072105:Superoxide Dismutase-1 / Q000032:analysis* / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D000072105:Superoxide Dismutase-1