title: Estrogen-dependent expression of sine oculis homeobox 1 in the mouse uterus during the estrous cycle.
abstract: The sine oculis homeobox 1 (SIX1) is a member of the Six gene family. SIX1 is involved in tissue development by regulating proliferation, apoptosis, and differentiation. However, function of SIX1 in the uterus remains unknown. Here, we found that Six1 expression is regulated along the estrous cycle in mouse uterus. Six1 expression was significantly increased at estrus stage and decreased at the rest of stages. SIX1 is detected in the luminal and glandular epithelium of uterine endometrium at the estrus stage. Estrogen injection increased Six1 expression in the ovariectomized mouse uterus, whereas progesterone had no effect on its expression. Estrogen receptor antagonist inhibited estrogen-induced Six1 expression. Our findings imply that SIX1 may play a role as an important regulator to orchestrate the dynamic of uterine endometrium in response to estrogen level during the estrous cycle. These results will give us a better understanding of uterine biology.
authors.affiliation: Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-do 13488, Republic of Korea.
authors.forename: Sijeong
authors.initials: S
authors.lastname: Bae
authors.affiliation: Fertility Center of CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do 13496, Republic of Korea.
authors.forename: Hwang
authors.initials: H
authors.lastname: Kwon
authors.affiliation: Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-do 13488, Republic of Korea.
authors.forename: Hyemin
authors.initials: H
authors.lastname: Yoon
authors.affiliation: Fertility Center of CHA Gangnam Medical Center, Seoul 06135, Republic of Korea.
authors.forename: Miseon
authors.initials: M
authors.lastname: Park
authors.affiliation: Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-do 13488, Republic of Korea.
authors.forename: Hye-Ryun
authors.initials: HR
authors.lastname: Kim
authors.affiliation: Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-do 13488, Republic of Korea.
authors.forename: Haengseok
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan-si, Chungcheongnam-do 31116, Republic of Korea. Electronic address: kwonho.hong@dankook.ac.kr.
authors.forename: Kwonho
authors.initials: K
authors.lastname: Hong
authors.affiliation: Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-do 13488, Republic of Korea; Fertility Center of CHA Gangnam Medical Center, Seoul 06135, Republic of Korea. Electronic address: youngsokchoi@cha.ac.kr.
authors.forename: Youngsok
authors.initials: Y
authors.lastname: Choi
mesh_terms: D000818:Animals; D004967:Estrogens / Q000378:metabolism*; D030762:Estrous Cycle / Q000502:physiology*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D018398:Homeodomain Proteins / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D011960:Receptors, Estrogen / Q000378:metabolism*
chemical_list: D004967:Estrogens; D018398:Homeodomain Proteins; D011960:Receptors, Estrogen; C490947:Six1 protein, mouse
keywords: Estrogen; Estrous cycle; Six1; Uterus