title: Presynaptic Adenosine Receptor-Mediated Regulation of Diverse Thalamocortical Short-Term Plasticity in the Mouse Whisker Pathway.
abstract: Short-term synaptic plasticity (STP) sets the sensitivity of a synapse to incoming activity and determines the temporal patterns that it best transmits. In "driver" thalamocortical (TC) synaptic populations, STP is dominated by depression during stimulation from rest. However, during ongoing stimulation, lemniscal TC connections onto layer 4 neurons in mouse barrel cortex express variable STP. Each synapse responds to input trains with a distinct pattern of depression or facilitation around its mean steady-state response. As a result, in common with other synaptic populations, lemniscal TC synapses express diverse rather than uniform dynamics, allowing for a rich representation of temporally varying stimuli. Here, we show that this STP diversity is regulated presynaptically. Presynaptic adenosine receptors of the A1R type, but not kainate receptors (KARs), modulate STP behavior. Blocking the receptors does not eliminate diversity, indicating that diversity is related to heterogeneous expression of multiple mechanisms in the pathway from presynaptic calcium influx to neurotransmitter release.
authors.affiliation: Instituto de Neurociencias de Alicante UMH-CSIC Sant Joan d'Alacant, Spain.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ferrati
authors.affiliation: Instituto de Neurociencias de Alicante UMH-CSIC Sant Joan d'Alacant, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Martini
authors.affiliation: Instituto de Neurociencias de Alicante UMH-CSICSant Joan d'Alacant, Spain; School of Life Sciences, Sussex Neuroscience, University of SussexBrighton, UK.
authors.forename: Miguel
authors.initials: M
authors.lastname: Maravall
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000378:metabolism; D004558:Electric Stimulation; D018683:Excitatory Amino Acid Agents / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D017729:Presynaptic Terminals / Q000378:metabolism*; D058905:Purinergic Agents / Q000494:pharmacology; D018047:Receptors, Purinergic P1 / Q000378:metabolism*; D013003:Somatosensory Cortex / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*; D014738:Vibrissae / Q000294:innervation*
chemical_list: D018683:Excitatory Amino Acid Agents; D058905:Purinergic Agents; D018047:Receptors, Purinergic P1; D002118:Calcium
keywords: in vitro; patch clamp; short-term plasticity; somatosensory; tactile; vibrissae; whole-cell