title: Influence of Corynebacterium pseudotuberculosis infection on level of acute phase proteins in goats.
abstract: BACKGROUND
  Goat caseous lymphadenitis (CLA) is a chronic disease caused by Corynebacterium pseudotuberculosis. However, there is paucity of data about goat's acute phase response during the course of CLA. This study was conducted to investigate the response of acute phase proteins, mainly haptoglobin (Hp), serum amyloid A (SAA) and the negative acute phase response, especially albumin after an experimental challenge of C. pseudotuberculosis and phospholipase D (PLD) in Cross bred Boer goats.
  
  
  RESULTS
  Serum Hp concentration in goats challenged with C. pseudotuberculosis (inoculated with 1x10(9) cfu subcutaneously) showed a significant increase, 5 fold in males (0.98 ± 0.12 mg/ml) and 3 fold in females (0.66 ± 0.12 mg/ml) compared to the control (0.2 ± 0.02 mg/ml). Challenge with PLD (1 ml/20 kg body weight intravenously) also showed significant increase, 4 fold in males and females (0.89 ± 0.11 mg/ml; 0.82 ± 0.12 mg/ml) respectively compared to the control (0.2 ± 0.02 mg/ml). Albumin concentration showed a significant decrease in both treated groups compared to the control. There were no significant changes in SAA concentration between challenged and control goats.
  
  
  CONCLUSIONS
  There was a significant response by Hp to C. pseudotuberculosis infection and PLD challenge. This was supported by the early acute response in which Hp was detected before CLA lesions were developed. Therefore, it concluded that C. pseudotuberculosis and PLD can influence the level of acute phase proteins in goats.
authors.affiliation: Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, UPM, Serdang, Selangor, Malaysia. zaid.jeber@Gmail.com.
authors.forename: Z K H
authors.initials: ZK
authors.lastname: Jeber
authors.affiliation: Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, UPM, Serdang, Selangor, Malaysia. zurinazlin_lin@yahoo.com.
authors.forename: Z
authors.initials: Z
authors.lastname: MohdJin
authors.affiliation: Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, UPM, Serdang, Selangor, Malaysia. jesse@putra.upm.edu.my.
authors.forename: F F
authors.initials: FF
authors.lastname: Jesse
authors.affiliation: Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, UPM, Serdang, Selangor, Malaysia. abdaziz@upm.edu.my.
authors.forename: A A
authors.initials: AA
authors.lastname: Saharee
authors.affiliation: Department of Clinical Studies, Faculty of Veterinary Medicine, UMK, Kelantan, Malaysia. jasni@umk.edu.my.
authors.forename: J
authors.initials: J
authors.lastname: Sabri
authors.affiliation: Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, UPM, Serdang, Selangor, Malaysia. rosnina@vet.upm.edu.my.
authors.forename: R
authors.initials: R
authors.lastname: Yusoff
authors.affiliation: Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, UPM, Serdang, Selangor, Malaysia. wahid@vet.upm.edu.my.
authors.forename: H
authors.initials: H
authors.lastname: Wahid
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000818:Animals; D003354:Corynebacterium Infections / Q000097:blood / Q000662:veterinary*; D016925:Corynebacterium pseudotuberculosis; D005260:Female; D006041:Goats / Q000097:blood*; D006242:Haptoglobins / Q000378:metabolism; D008297:Male; D010739:Phospholipase D / Q000494:pharmacology; D000685:Serum Amyloid A Protein / Q000378:metabolism
chemical_list: D000209:Acute-Phase Proteins; D006242:Haptoglobins; D000685:Serum Amyloid A Protein; D010739:Phospholipase D