title: A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.
abstract: The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.
authors.affiliation: Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogerstr. 30, München 81675, Germany. Anna.Waldhuber@med.uni-muenchen.de.
authors.forename: Anna
authors.initials: A
authors.lastname: Waldhuber
authors.affiliation: Institute of Human Virology, Departments of Medicine, and Microbiology and Immunology, University of Maryland, School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA. GSnyder@ihv.umaryland.edu.
authors.forename: Greg A
authors.initials: GA
authors.lastname: Snyder
authors.affiliation: Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogerstr. 30, München 81675, Germany. franziska.roemmler@tum.de.
authors.forename: Franziska
authors.initials: F
authors.lastname: Römmler
authors.affiliation: Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogerstr. 30, München 81675, Germany. ccirl@gmx.de.
authors.forename: Christine
authors.initials: C
authors.lastname: Cirl
authors.affiliation: Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogerstr. 30, München 81675, Germany. tina.mueller@tum.de.
authors.forename: Tina
authors.initials: T
authors.lastname: Müller
authors.affiliation: Department of Pathology, Case Western Reserve University, 2103 Cornell Rd, Cleveland, OH 44106, USA. tsan.xiao@case.edu.
authors.forename: Tsan Sam
authors.initials: TS
authors.lastname: Xiao
authors.affiliation: Department of Microbiology, Immunology and Glycobiology (MIG), Institute of Laboratory Medicine, Lund University, 221 00 Lund, Sweden. catharina.svanborg@med.lu.se.
authors.forename: Catharina
authors.initials: C
authors.lastname: Svanborg
authors.affiliation: Institute of Medical Microbiology and Hygiene, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany. Thomas.Miethke@medma.uni-heidelberg.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Miethke
keywords: TIR-containing proteins; TIR-domain structure; Toll-like receptors; bacterial pathogens