title: Retrospective Evaluation of Children with Congenital Pulmonary Airway Malformation: A Single Center Experience of 20 Years.
abstract: OBJECTIVE
  Congenital pulmonary airway malformation (CPAM) is an uncommon congenital abnormality of the lungs that generally presents during prenatal period or early childhood. In this study, we aimed to evaluate clinical and pathologic findings of the children with CPAMs who were referred to our center between 1992 and 2011.
  
  
  METHODS
  We reviewed 19 children with CPAM, who were diagnosed and treated at the Izmir Dr. Behçet Uz Children's Hospital between 1992 and 2011. All of them are alive and have been still followed up by our center.
  
  
  RESULTS
  The study population consisted of 9 boys (47.4%) and 10 girls (52.6%) with a mean age of 3.26 (1 month - 13 years). Most newborns had respiratory distress, while recurrent pulmonary infections were detected in older children. Surgical treatment was performed on patients with subtypes I (n = 4; 21.1%), II (n = 8; 42.1%), III (n = 5; 26.3%), and IV (n = 2; 10.5%). In 13 cases (63.4%), lesions were located in the right lung and in almost all cases lesions were confined to one lobe. A one-month- old child with type I CPAM had multiple lesions involving two lobes and in only a newborn with type II CPAM, lesions were located bilaterally. There was no type 0 cases in this series. All cases were treated with lobectomy without any complication.
  
  
  CONCLUSIONS
  In the present study, a realistic comprehensive picture of CPAM in a central children's hospital has been provided. In addition, we want to emphasize that complications and unnecessary medical treatment could be reduced with early surgery.
authors.affiliation: a Pathology Department , Izmir University Medical Park Hospital , Izmir , Turkey.
authors.forename: Ragip
authors.initials: R
authors.lastname: Ortac
authors.affiliation: b Pathology Department , İzmir Tepecik Hospital , Izmir , Turkey.
authors.forename: Gulden
authors.initials: G
authors.lastname: Diniz
authors.affiliation: c Pathology Department , İzmir Dr. Behçet Uz Children's Hospital , Izmir , Turkey.
authors.forename: Hulya Tosun
authors.initials: HT
authors.lastname: Yildirim
authors.affiliation: d Basic Oncology Department , İzmir Dokuz Eylul University , Izmir , Turkey.
authors.forename: Safiye
authors.initials: S
authors.lastname: Aktas
authors.affiliation: e Pediatric Surgery Department , İzmir University Medical Park Hospital , Izmir , Turkey.
authors.forename: Irfan
authors.initials: I
authors.lastname: Karaca
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000473:pathology; D008168:Lung / Q000002:abnormalities / Q000473:pathology*; D008297:Male; D015619:Respiratory System Abnormalities / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods
keywords: Congenital cystic adenomatoid malformation; a single center experience; congenital pulmonary airway malformation