title: Differential screening-selected gene aberrative in neuroblastoma (DAN) is increased in the CSF of patients with MS and may be induced by therapy with interferon-β.
abstract: Bone morphogenic proteins (BMPs) signaling blockade induce neurogenesis and oligodendrogenesis. Differential screening-selected gene aberrative in neuroblastoma (DAN) is a glycoprotein that antagonizes BMPs. We found that DAN levels were higher in CSF compared to serum in all participants. CSF-DAN levels were elevated in RR-and progresssive MS patients compared to controls. Moreover, serum-DAN levels were reduced in those patients, but elevated in IFN-β1a treated patients. The main source of DAN is apparently CNS- resident cells. The enhanced levels of CSF-DAN in MS patients suggest a tendency to induce neurogenesis/oligodendrogenesis in the patients CNS. Our results suggest an unreported mode of action of IFN-β1a.
authors.affiliation: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel.
authors.forename: Karin
authors.initials: K
authors.lastname: Mausner-Fainberg
authors.affiliation: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel.
authors.forename: Hadar
authors.initials: H
authors.lastname: Kolb
authors.affiliation: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel.
authors.forename: Moran
authors.initials: M
authors.lastname: Penn
authors.affiliation: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel.
authors.forename: Keren
authors.initials: K
authors.lastname: Regev
authors.affiliation: Department of Neurology, and Laboratory of Neuroimmunology, Ein-Karem, Jerusalem, Israel; Agnes-Ginges Center for Neurogenetics, Hadassah Medical Center, Ein-Karem, Jerusalem, Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Vaknin-Dembinsky
authors.affiliation: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel.
authors.forename: Avi
authors.initials: A
authors.lastname: Gadoth
authors.affiliation: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel.
authors.forename: Meir
authors.initials: M
authors.lastname: Kestenbaum
authors.affiliation: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: arnonk@tlvmc.gov.il.
authors.forename: Arnon
authors.initials: A
authors.lastname: Karni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000134:cerebrospinal fluid; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors* / Q000276:immunology; D018797:Cell Cycle Proteins; D002478:Cells, Cultured; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000188:drug therapy*; D009447:Neuroblastoma / Q000134:cerebrospinal fluid* / Q000235:genetics; D011506:Proteins / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000906:Antibodies; D019485:Bone Morphogenetic Proteins; D018797:Cell Cycle Proteins; C490087:NBL1 protein, human; D011506:Proteins; D016899:Interferon-beta
keywords: Bone morphogenic proteins; Cerebrospinal fluid; Differential screening-selected gene aberrative in neuroblastoma (DAN); Interferon-β; Multiple sclerosis; Neurogenesis; Oligodendrogenesis