title: Identification of a Novel CRF01_AE/CRF07_BC Recombinant Form in Men Who Have Sex with Men in Sichuan, China.
abstract: A novel second-generation CCR5-tropic HIV-1 recombinant virus (XC2014EU09) was identified here, which was isolated from a HIV-positive man who had sex with men (MSM) in Sichuan, China. Phylogenic analyses showed that XC2014EU09 was composed of two well-established circulating recombinant forms (CRF01_AE and CRF07_BC). Different from the other four reported CRF01_AE/CRF07_BC recombinant forms, three recombinant breakpoints of XC2014EU09 with four fragments were observed in the vpr, env, and nef genes, respectively, as follows: ICRF01_AE (636-5,843 nt), IICRF07_BC (5,844-8,393 nt), IIICRF01_AE (8,394-9,119 nt), and IVCRF07_BC (9,120-9,600 nt). The emergence of CRF01_AE/CRF07_BC recombinant strain indicates the increasing complexity of the HIV-1 epidemic among the MSM group in China.
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 2 MOH Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology, and AIDS Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing, People's Republic of China .
authors.forename: Huamian
authors.initials: H
authors.lastname: Wei
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Weisi
authors.initials: W
authors.lastname: Xu
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Yin
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: 3 Sichuan Center for Disease Control and Prevention , Chengdu, People's Republic of China .
authors.forename: Shu
authors.initials: S
authors.lastname: Liang
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Liying
authors.initials: L
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D010802:Phylogeny; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D056189:Viral Tropism; D055815:Young Adult