title: Comparison of Electrochemical Immunosensors and Aptasensors for Detection of Small Organic Molecules in Environment, Food Safety, Clinical and Public Security.
abstract: We review here the most frequently reported targets among the electrochemical immunosensors and aptasensors: antibiotics, bisphenol A, cocaine, ochratoxin A and estradiol. In each case, the immobilization procedures are described as well as the transduction schemes and the limits of detection. It is shown that limits of detections are generally two to three orders of magnitude lower for immunosensors than for aptasensors, due to the highest affinities of antibodies. No significant progresses have been made to improve these affinities, but transduction schemes were improved instead, which lead to a regular improvement of the limit of detections corresponding to ca. five orders of magnitude over these last 10 years. These progresses depend on the target, however.
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR 7086 CNRS, 15 rue J-A de Baïf, Paris 75205, France. piro@univ-paris-diderot.fr.
authors.forename: Benoit
authors.initials: B
authors.lastname: Piro
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR 7086 CNRS, 15 rue J-A de Baïf, Paris 75205, France. shshh2008@hotmail.com.
authors.forename: Shihui
authors.initials: S
authors.lastname: Shi
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR 7086 CNRS, 15 rue J-A de Baïf, Paris 75205, France. steeve.reisberg@univ-paris-diderot.fr.
authors.forename: Steeve
authors.initials: S
authors.lastname: Reisberg
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR 7086 CNRS, 15 rue J-A de Baïf, Paris 75205, France. vincent.noel@univ-paris-diderot.fr.
authors.forename: Vincent
authors.initials: V
authors.lastname: Noël
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR 7086 CNRS, 15 rue J-A de Baïf, Paris 75205, France. guillaume.anquetin@univ-paris-diderot.fr.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Anquetin
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis*; D001559:Benzhydryl Compounds / Q000032:analysis*; D015374:Biosensing Techniques / Q000379:methods; D003042:Cocaine / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods; D059022:Food Safety; D006801:Humans; D009793:Ochratoxins / Q000032:analysis*; D010636:Phenols / Q000032:analysis*; D000098826:Bisphenol A Compounds
chemical_list: D000900:Anti-Bacterial Agents; D001559:Benzhydryl Compounds; D003042:Cocaine; D009793:Ochratoxins; D010636:Phenols; C025589:ochratoxin A; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: ampicillin; aptasensor; bisphenol A; ciprofloxacin; cocaine; enrofloxacin; estradiol; immunosensor; kanamycin; neomycin; ochratoxin A; ofloxacin; sulfonamides; tetracyclines; tobramycin