title: Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation.
abstract: The mechanistic target of rapamycin complex 1 (mTORC1) coordinates nutrient availability with cell growth. Recent reports by Sabatini and coworkers (Saxton et al., 2016; Wolfson et al., 2016) characterize a cytoplasmic amino acid receptor that couples the binding of leucine to the activation of mTORC1.
authors.affiliation: Oncology-Rinat R&D Group, Pfizer Worldwide Research & Development, 10646 Science Center Drive/CB4, San Diego, CA 92121, USA. Electronic address: robert.abraham@pfizer.com.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Abraham