title: (131)I-labeled multifunctional dendrimers modified with BmK CT for targeted SPECT imaging and radiotherapy of gliomas.
abstract: The poly(amidoamine) dendrimers modified with Buthus martensii Karsch chlorotoxin (BmK CT) were developed as a (131)I delivery system for glioma-targeted imaging and therapy.
  
  
  
  Dendrimers before and after labeling (131)I were synthetized and their physicochemical properties were tested. The targeting and therapeutic efficacy of (131)I-G5.NHAc-HPAO-(PEG-BmK CT)-(mPEG) dendrimer against glioma was evaluated in vitro and in vivo.
  
  
  
  All the dendrimers were stable under different conditions. BmK CT modification increased the cellular uptake of dendrimers in C6 glioma cells, but not in the normal RLE-6TN cells. (131)I-G5.NHAc-HPAO-(PEG-BmK CT)-(mPEG) dendrimer was radiochemically pure and could be applied in glioma-targeting single-photon emission CT (SPECT) imaging and radiotherapy.
  
  
  
  (131)I-G5.NHAc-HPAO-(PEG-BmK CT)-(mPEG) complex is a promising multifunctional nanoplatform for glioma-specific nuclear imaging and radiotherapy.
authors.affiliation: Department of Nuclear Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, People's Republic of China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers & Polymer Materials, College of Materials Science & Engineering, Donghua University, Shanghai 201620, People's Republic of China.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Nuclear Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, People's Republic of China.
authors.forename: Lingzhou
authors.initials: L
authors.lastname: Zhao
authors.affiliation: College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Xiong
authors.affiliation: Experiment Center, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, People's Republic of China.
authors.forename: Yueqin
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Nuclear Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, People's Republic of China.
authors.forename: Changcun
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Nuclear Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, People's Republic of China.
authors.forename: Lilei
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Nuclear Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, People's Republic of China.
authors.forename: Wenli
authors.initials: W
authors.lastname: Qiao
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers & Polymer Materials, College of Materials Science & Engineering, Donghua University, Shanghai 201620, People's Republic of China.|College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Nuclear Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, People's Republic of China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002460:Cell Line; D045744:Cell Line, Tumor; D050091:Dendrimers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005910:Glioma / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011073:Polyamines / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D051381:Rats; D012604:Scorpion Venoms / Q000737:chemistry*; D012605:Scorpions / Q000737:chemistry; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D050091:Dendrimers; D007457:Iodine Radioisotopes; C531249:Poly(amidoamine); D011073:Polyamines; D012604:Scorpion Venoms; C091539:Chlorotoxin; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol
keywords: 131I; BmK CT; MMP-2; SPECT; cancer; cholorotoxin; dendrimer; glioma; imaging; radiotherapy