title: The osteogenic capacity of biomimetic hierarchical micropore/nanorod-patterned Sr-HA coatings with different interrod spacings.
abstract: Advanced titanium based bone implant with fast established, rigid and stable osseointegration is stringently needed in clinic. Here the hierarchical micropore/nanorod-patterned strontium doped hydroxyapatite (Ca9Sr1(PO4)6(OH)2, Sr1-HA) coatings (MNRs) with different interrod spacings varying from about 300 to 33nm were developed. MNRs showed dramatically differential biological performance closely related to the interrod spacing. Compared to micropore/nanogranule-patterned Sr1-HA coating (MNG), MNRs with an interrod spacing of larger than 137nm resulted in inhibited in vitro mesenchymal stem cell functions and in vivo osseointegration, while those of smaller than 96nm gave rise to dramatically enhanced the biological effect, especially those of mean 67nm displayed the best effect. The differential biological effect of MNRs was related to their modulation on the focal adhesion mediated mechanotransduction. These results suggest that MNRs with a mean interrod spacing of 67nm may give rise to an advanced implant of improved clinical performance.
authors.affiliation: State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, China; Institute of Physics & Optoelectronics Technology, Baoji University of Arts and Sciences, Baoji, China.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Zhou
authors.affiliation: State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, China. Electronic address: yonghan@mail.xjtu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Han
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, China. Electronic address: zhaolingzhou1983@hotmail.com.
authors.forename: Lingzhou
authors.initials: L
authors.lastname: Zhao
mesh_terms: D032701:Biomimetics; D020099:Coated Materials, Biocompatible; D017886:Durapatite; D006801:Humans; D040542:Mechanotransduction, Cellular; D043942:Nanotubes; D016348:Osseointegration; D010012:Osteogenesis; D014025:Titanium
chemical_list: D020099:Coated Materials, Biocompatible; D017886:Durapatite; D014025:Titanium
keywords: Hierarchical biomimetic topography; Interrod spacing; Mechanotransduction; Nanorod arrays; Osseointegration