title: Connective tissue diseases: Mitochondria drive NETosis and inflammation in SLE.
abstract: Mitochondria are the powerhouses of the cell, providing energy through oxidative respiration. Possibly owing to their similarities with bacteria, however, mitochondria extruded from cells promote inflammation. New research demonstrates that in systemic lupus erythematosus, mitochondrial respiration is critical in neutrophil extracellular trap formation, and that mitochondria released by neutrophils induce inflammatory cytokine production.
authors.affiliation: Department of Infectious Diseases and Immunity, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l'Université Laval, 2705, Boulevard Laurier, Quebec City, Quebec G1V 4G2, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Boilard
authors.affiliation: Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Axe Maladies Infectieuses et Immunitaires and Division of Rheumatology, Department of Medicine, Université Laval, 2705, Boulevard Laurier, Quebec City, Quebec G1V 4G2, Canada.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Fortin
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000378:metabolism*; D065206:Extracellular Traps / Q000276:immunology*; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D009504:Neutrophils / Q000276:immunology*
chemical_list: D004272:DNA, Mitochondrial