title: Novel myokine: irisin may be an independent predictor for subclinic atherosclerosis in Behçet's disease.
abstract: Behçet's disease (BD) is a vasculitic and inflammatory disease causing endothelial dysfunction. Irisin is a metabolic hormone related to insulin resistance and endothelial functions. In this study, we investigated the relationship between irisin and carotid intima-media thickness (cIMT), which is a marker of atherosclerosis in patients with BD. 48 patients with BD and 50 healthy individuals were enrolled in the study. Disease severity was evaluated by BD current activity form. Irisin, glucose, insulin, C reactive protein, erythrocyte sedimentation rate and lipid panel were examined in all patients. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was used to calculate insulin resistance. A simple and inexpensive cIMT test was used as indicator of atherosclerosis. cIMT was 0.62 (0.45-1.05) mm in the patients, while it was 0.38 (0.25-0.65) mm in the control group (p < 0.001). Irisin value was found to be 197.3 (24.8-834.2) ng/mL in the control group, while it was 85.4 (4.7-471.1) ng/mL in the patient group (p = 0.007). There was a negative correlation between irisin level and cIMT (r = -0.511, p < 0.001) and HOMA-IR (r = -0.371, p = 0.009). Decreased irisin levels (OR 0.996, 95% CI 0.992 to 1.000, p = 0.041), male gender (OR 7.634, 95% CI 1.415 to 41.191, p = 0.018), and HOMA-IR (OR 2.596, 95% CI 1.451 to 4.643, p = 0.001) are independent risk factors for cIMT in patients with BD. We detected a very strong relationship between cIMT, which is an indicator of subclinical atherosclerosis, and decreased irisin levels in patients with BD. BD is characterized by chronic inflammation, and low serum irisin levels in BD may be related to atherosclerosis.
authors.affiliation: Department of Cardiology, Meram, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Icli
authors.affiliation: Department of Internal Medicine, Recep Tayyip Erdogan Universitesi, Rize, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Cure
authors.affiliation: Department of Biochemistry, Recep Tayyip Erdogan Universitesi, Rize, Turkey.
authors.forename: Medine
authors.initials: M
authors.lastname: Cumhur Cure
authors.affiliation: Eskisehir Military Hospital, Eskisehir, Turkey.
authors.forename: Ali Ugur
authors.initials: AU
authors.lastname: Uslu
authors.affiliation: Department of Cardiology, Gulhane Askeri Tip Akademisi, Ankara, Turkey.
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.affiliation: Division of Allergy and Clinical Immunology, Department of Internal Medicine, Necmettin Erbakan Universitesi Meram Tip Fakultesi, Konya, Turkey.
authors.forename: Sevket
authors.initials: S
authors.lastname: Arslan
authors.affiliation: Department of Internal Medicine, Necmettin Erbakan Universitesi Meram Tip Fakultesi, Konya, Turkey.
authors.forename: Davut
authors.initials: D
authors.lastname: Sakiz
authors.affiliation: Department of Rheumatology, Necmettin Erbakan Universitesi Meram Tip Fakultesi, Konya, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Kucuk
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications* / Q000473:pathology; D001528:Behcet Syndrome / Q000097:blood* / Q000150:complications* / Q000473:pathology; D015992:Body Mass Index; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D016015:Logistic Models; D008297:Male
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins
keywords: Atherosclerosis; Inflammation