title: A case report of severe ulcerative colitis with mediastinal and subcutaneous emphysema.
abstract: A 17-year-old boy developed prominent mediastinal and subcutaneous emphysema while receiving treatment with 5-aminosalicylic acid (5-ASA) and oral corticosteroids for severe ulcerative colitis. We ruled out infection and initiated oral administration of tacrolimus, after which both the underlying disease and mediastinal and subcutaneous emphysema improved. However, he continued to experience repeated bouts of ulcerative colitis, so we ultimately opted for surgical intervention. Although mediastinal and subcutaneous emphysema is rare, it is one of the known extra-intestinal complications and can be particularly concerning. In this patient, mediastinal and subcutaneous emphysema might have been caused by the vulnerability of pulmonary alveolar walls to steroid medication and the increase of pulmonary alveolar pressure with abdominal pain and breath holding. Here, we report a case of inflammatory bowel disease with mediastinal and subcutaneous emphysema, along with a review of the literature.
authors.affiliation: Department of Gastroenterology, Japanese Red Cross Kyoto Daiichi Hospital.
authors.forename: Kei
authors.initials: K
authors.lastname: Terasaki
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Okuyama
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ueda
authors.forename: Kiichi
authors.initials: K
authors.lastname: Matsuyama
authors.forename: Yoji
authors.initials: Y
authors.lastname: Urata
authors.forename: Norimasa
authors.initials: N
authors.lastname: Yoshida
mesh_terms: D000293:Adolescent; D003093:Colitis, Ulcerative / Q000150:complications*; D006801:Humans; D008297:Male; D008478:Mediastinal Emphysema / Q000209:etiology*; D013352:Subcutaneous Emphysema / Q000209:etiology*