title: Urine phyto-oestrogen metabolites are not significantly associated with risk of type 2 diabetes: the Singapore Chinese health study.
abstract: We evaluated the relationship between urine concentrations of phyto-oestrogens (isoflavones and lignans) and risk of incident type 2 diabetes in middle-aged and elderly Chinese residing in Singapore. Urine metabolites of isoflavones and lignans were assayed by HPLC among 564 diabetes cases and 564 matched controls in a case-control study nested within the Singapore Chinese Health Study cohort. Participants were free of diagnosed diabetes, CVD and cancer at morning urine collections during 1999-2004. Cases were participants who reported to have physician-diagnosed diabetes at follow-up visits during 2006-2010, whereas controls were randomly selected among those who remained free of diabetes and were matched to the index cases by age, sex, dialect group and date of urine collection. Conditional logistic regression models were used to calculate OR and 95 % CI with adjustment for potential confounders. The mean age of the participants at the time of urine collection was 59·8 years, and the average interval between urine collection and diabetes diagnosis was 4·0 years. The multivariate-adjusted OR for diabetes were 1·00 (reference), 0·76 (95 % CI 0·52, 1·11), 0·78 (95 % CI 0·53, 1·14) and 0·79 (95 % CI 0·54, 1·15) across quartiles of urine isoflavones (P for trend=0·54), and were 1·00 (reference), 0·87 (95 % CI 0·60, 1·27), 1·10 (95 % CI 0·77, 1·56) and 0·93 (95 % CI 0·63, 1·37) for lignans (P for trend=0·93). The results were similar in men and women, as well as for individual metabolites of isoflavones (genistein, daidzein, glycitin and equol) or lignans (enterodiol and enterolactone). The present study did not find a significant association between urine phyto-oestrogen metabolites and risk of type 2 diabetes in Chinese adults.
authors.affiliation: 1Saw Swee Hock School of Public Health,National University of Singapore and National University Health System,Singapore 117549,Singapore.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Talaei
authors.affiliation: 1Saw Swee Hock School of Public Health,National University of Singapore and National University Health System,Singapore 117549,Singapore.
authors.forename: Bee L
authors.initials: BL
authors.lastname: Lee
authors.affiliation: 1Saw Swee Hock School of Public Health,National University of Singapore and National University Health System,Singapore 117549,Singapore.
authors.forename: Choon N
authors.initials: CN
authors.lastname: Ong
authors.affiliation: 1Saw Swee Hock School of Public Health,National University of Singapore and National University Health System,Singapore 117549,Singapore.
authors.forename: Rob M
authors.initials: RM
authors.lastname: van Dam
authors.affiliation: 4Division of Cancer Control and Population Sciences,University of Pittsburgh Cancer Institute,Pittsburgh,PA 15232,USA.
authors.forename: Jian M
authors.initials: JM
authors.lastname: Yuan
authors.affiliation: 6Duke-NUS Graduate Medical School,Singapore 169857,Singapore.
authors.forename: Woon P
authors.initials: WP
authors.lastname: Koh
authors.affiliation: 7Department of Epidemiology and Biostatistics,MOE Key Laboratory of Environment and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,People's Republic of China.
authors.forename: An
authors.initials: A
authors.lastname: Pan
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000209:etiology / Q000517:prevention & control / Q000652:urine; D060754:Equol / Q000652:urine; D005260:Female; D019833:Genistein / Q000652:urine; D006801:Humans; D007529:Isoflavones / Q000652:urine*; D017705:Lignans / Q000652:urine*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D048789:Phytoestrogens / Q000652:urine*; D012307:Risk Factors; D012846:Singapore
chemical_list: D007529:Isoflavones; D017705:Lignans; D048789:Phytoestrogens; D060754:Equol; C004742:daidzein; D019833:Genistein; C433283:glycitin
keywords: CRP C-reactive protein; Incidence; Isoflavones; Lignans; NHS Nurse’s Health Study; SCHS Singapore Chinese Health Study; T2D type 2 diabetes; Type 2 diabetes; Urine metabolites