title: Common antigens between hydatid cyst and cancers.
abstract: BACKGROUND
  Different research groups reported a negative correlation between cancers and parasitical infections. As an example, the prevalence of a hydatid cyst among patients with cancer was significantly lower than its prevalence among normal population. Tn antigens exist both in cancer and hydatid cyst. This common antigen may be involved in the effect of parasite on cancer growth. So in this work, common antigens between hydatid cyst and cancers have been investigated.
  
  
  METHODS
  Different hydatid cyst antigens including hydatid fluid, laminated and germinal layer antigens, and excretory secretory antigens of protoscolices were run in SDS PAGE and transferred to NCP paper. In western immunoblotting, those antigens were probed with sera of patients with different cancer and also sera of non-cancer patients. Also, cross reaction among excretory secretory products of cancer cells and antisera raised against different hydatid cyst antigen was investigated.
  
  
  RESULTS
  In western immunoblotting, antisera raised against laminated and germinal layers of hydatid cyst reacted with excretory secretory products of cancer cells. Also, a reaction was detected between hydatid cyst antigens and sera of patients with some cancers.
  
  
  CONCLUSIONS
  Results of this work emphasize existence of common antigens between hydatid cyst and cancers. More investigation about these common antigens is recommended.
authors.affiliation: Department of Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Daneshpour
authors.affiliation: Department of Parasitology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Bahadoran
authors.affiliation: Department of Parasitology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Seyed Hossein
authors.initials: SH
authors.lastname: Hejazi
authors.affiliation: Department of Parasitology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Abas Ali
authors.initials: AA
authors.lastname: Eskandarian
authors.affiliation: Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Mahmoudzadeh
authors.affiliation: Department of Parasitology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Hossein Yousofi
authors.initials: HY
authors.lastname: Darani
keywords: Cancer; common antigen; hydatid cyst