title: Increased calcium-independent lipoprotein phospholipase A2 but not protein S100 in patients with schizophrenia.
abstract: BACKGROUND
  The aim of this paper was to investigate serum concentrations of calcium-independent lipoprotein phospholipase A2 (PLA2) and protein S100 in schizophrenia patients in comparison to healthy controls and correlate them with the clinical severity, duration, and number of schizophrenia relapses.
  
  
  METHODS
  This study included 65 schizophrenia patients and 70 controls. Schizophrenia was diagnosed according to DSM-IV-TR criteria. Clinical severity was determined by PANSS. PLA2 and protein S100 concentration were assessed by the enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  PLA2 concentrations were higher in patients with schizophrenia, whereas protein S100 concentrations were not. Higher concentrations of PLA2 were positively correlated with the duration of illness and number of episodes, as determined by multivariate analysis.
  
  
  CONCLUSIONS
  PLA2 might be considered a possible biochemical trait marker for schizophrenia. Further research with larger and more homogeneous clinical samples is required.
authors.affiliation: Department of Psychiatry, University Hospital Center "Sestre Milosrdnice", Vinogradska cesta 29, 10 000 Zagreb, Croatia.
authors.forename: Maristela
authors.initials: M
authors.lastname: Šakić
authors.forename: Dalibor
authors.initials: D
authors.lastname: Karlović
authors.forename: Branka
authors.initials: B
authors.lastname: Vidrih
authors.forename: Vjekoslav
authors.initials: V
authors.lastname: Peitl
authors.forename: Danijel
authors.initials: D
authors.lastname: Crnković
authors.forename: Nada
authors.initials: N
authors.lastname: Vrkić
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054512:Phospholipases A2, Calcium-Independent / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D012559:Schizophrenia / Q000097:blood* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D064568:S100 Calcium Binding Protein beta Subunit; D054512:Phospholipases A2, Calcium-Independent