title: Mechanobiology of Ciliogenesis.
abstract: Cilia are force-generating and -sensing organelles that serve as mechanical interfaces between the cell and the extracellular environment. Cilia are present in tissues that adaptively respond to mechanical loading and fluid flow, and defects in ciliary function can lead to diseases affecting these tissues. As might be expected for a mechanical interface, the formation of cilia is, itself, regulated by mechanical forces, and these links between mechanics and ciliary formation are providing new entry points for dissecting the regulatory pathways of ciliogenesis.
authors.affiliation: Hiroaki Ishikawa and Wallace F. Marshall are affiliated with the Department of Biochemistry and Biophysics at the University of California San Francisco wallace.marshall@ucsf.edu .
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ishikawa
authors.affiliation: Hiroaki Ishikawa and Wallace F. Marshall are affiliated with the Department of Biochemistry and Biophysics at the University of California San Francisco wallace.marshall@ucsf.edu .
authors.forename: Wallace F
authors.initials: WF
authors.lastname: Marshall
keywords: biomechanics; calcium; cilia; developmental biology; hydrodynamics; mucus