title: Norharman and anxiety disorders.
abstract: Norharman is a ß-carboline, possibly of endogenous origin, although cigarette smoking and food are sources too. In brain specific binding sites have been demonstrated. In higher doses norharman binds to benzodiazepine receptors and has MAO-B inhibitory activity. From animal experiments it can be concluded that norharman induces sedation and muscle relaxation. A role in psychosis is unclear, a role in the pathogenesis in anxiety is possible, but has to be further substantiated. As current research suggests, norharman may be an important factor in addiction and withdrawal.
authors.forename: L
authors.initials: L
authors.lastname: Pepplinkhuizen
authors.forename: D
authors.initials: D
authors.lastname: Fekkes
authors.forename: L
authors.initials: L
authors.lastname: Timmerman