title: 1,2,3-Triazole Bridge as Conformational Constrain in β-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions.
abstract: Conformational constrained β-hairpin peptides are useful tool to modulate protein-protein interactions. A triazole bridge in hydrogen-bonded positions between two antiparallel strands induces a conformational stabilization of the β-hairpin peptide. The entity of the stability of the β-hairpin peptide depends on the length of the bridge.
authors.affiliation: Istituto di Biostrutture e Bioimmagini CNR, Via Mezzocannone 16, 80134, Napoli, (Italy).
authors.forename: V
authors.initials: V
authors.lastname: Celentano
authors.affiliation: Istituto di Biostrutture e Bioimmagini CNR, Via Mezzocannone 16, 80134, Napoli, (Italy).
authors.forename: D
authors.initials: D
authors.lastname: Diana
authors.affiliation: Istituto di Biostrutture e Bioimmagini CNR, Via Mezzocannone 16, 80134, Napoli, (Italy).|National University of Ireland, Galway, (Ireland).
authors.forename: C
authors.initials: C
authors.lastname: Di Salvo
authors.affiliation: Istituto di Biostrutture e Bioimmagini CNR, Via Mezzocannone 16, 80134, Napoli, (Italy).
authors.forename: L
authors.initials: L
authors.lastname: De Rosa
authors.affiliation: Dipartimento di Farmacia, Università di Napoli "Federico II", Via Mezzocannone 16, 80134, Napoli, (Italy).
authors.forename: A
authors.initials: A
authors.lastname: Romanelli
authors.affiliation: Dipartimento di Scienze Ambientali, Biologiche e Farmaceutiche, Seconda Università di Napoli, Via Vivaldi 46, 81100, Caserta, Napoli, (Italy).
authors.forename: R
authors.initials: R
authors.lastname: Fattorusso
authors.affiliation: Istituto di Biostrutture e Bioimmagini CNR, Via Mezzocannone 16, 80134, Napoli, (Italy). luca.dandrea@cnr.it.
authors.forename: L D
authors.identifier: http://orcid.org/0000-0002-2589-216X
authors.initials: LD
authors.lastname: D'Andrea
mesh_terms: D000595:Amino Acid Sequence; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D014230:Triazoles / Q000737:chemistry*
chemical_list: D010455:Peptides; D014230:Triazoles
keywords: NMR spectroscopy; click chemistry; cycloaddition; peptidomimetics; β-hairpin