title: Zinc sensing and regulation in yeast model systems.
abstract: The Zap1 transcription factor of Saccharomyces cerevisiae and the Loz1 transcription factor of Schizosaccharomyces pombe both play a central role in zinc homeostasis by controlling the expression of genes necessary for zinc metabolism. Zap1 activates gene expression when cells are limited for zinc, while Loz1 is required for gene repression when zinc is in excess. In this review we highlight what is known about the underlying mechanisms by which these factors are regulated by zinc, and how transcriptional activation and repression in eukaryotic cells can be finely tuned according to intracellular zinc availability.
authors.affiliation: Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Stevin
authors.initials: S
authors.lastname: Wilson
authors.affiliation: Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA; Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA. Electronic address: bird.96@osu.edu.
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Bird
mesh_terms: D015966:Gene Expression Regulation, Fungal; D006706:Homeostasis; D000072417:Protein Domains; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D015032:Zinc / Q000737:chemistry*; D016335:Zinc Fingers
chemical_list: C584539:Loz1 protein, S pombe; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; D014157:Transcription Factors; C103264:ZAP1 protein, S cerevisiae; D015032:Zinc
keywords: Loz1; Nutrient; Transcription; Yeast; Zap1; Zinc homeostasis