title: Checking the Biocompatibility of Plant-Derived Metallic Nanoparticles: Molecular Perspectives.
abstract: Understanding the biocompatibility of metallic nanoparticles (MNPs) is pivotal for biomedical applications. The biocompatibility of plant-derived MNPs has been mostly attributed to capped plant molecules. This claim seems to be straightforward but lacks conclusive evidence. The capped phytochemicals and the metallic core might have decisive and individual roles in imparting the overall biocompatibility. Whether capped phytochemicals really make sense in diminishing the toxicity effect of the otherwise naked or metallic core needs further analysis. Here, we readdress the biocompatibility of plant-derived MNPs with references to contemporary cellular assays, different reactants for green synthesis, possible epigenetic involvement, and nanobiocompatibility at the molecular level. Finally, we discuss relevant in vivo studies and large-scale production issues.
authors.affiliation: ETE Centre, INRS Université, 490, Rue de la Couronne, Québec, QC, G1K 9A9, Canada.
authors.forename: Ratul Kumar
authors.initials: RK
authors.lastname: Das
authors.affiliation: ETE Centre, INRS Université, 490, Rue de la Couronne, Québec, QC, G1K 9A9, Canada. Electronic address: satinder.brar@ete.inrs.ca.
authors.forename: Satinder Kaur
authors.initials: SK
authors.lastname: Brar
authors.affiliation: CO(2) Solutions Inc., 2300, rue Jean-Perrin, Québec, QC, G2C 1T9, Canada.
authors.forename: Mausam
authors.initials: M
authors.lastname: Verma
mesh_terms: D001681:Biological Assay / Q000379:methods; D003584:Cytological Techniques / Q000379:methods; D008422:Materials Testing / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity; D010944:Plants / Q000737:chemistry* / Q000633:toxicity*; D046888:Tissue Array Analysis / Q000379:methods*; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D010936:Plant Extracts
keywords: biocompatibility; cellular assay; epigenetics; metallic nanoparticles; nanobiocompatibility; phytochemicals