title: Successfully treated advanced esophageal cancer with left axillary lymph node metastasis and synchronous right breast cancer: a case report.
abstract: The incidence of double cancer of the esophagus and breast is rare, and axillary lymph node metastasis (ALM) in esophageal cancer is also very rare. We report a case of advanced esophageal cancer with left ALM and synchronous right breast cancer. A 64-year-old woman was admitted to our hospital with dysphagia. The clinical diagnosis was esophageal cancer (T3N0M1 stage IV) and right breast cancer (T1cN0M0 stage I). She was initially treated with triple chemotherapy with docetaxel, cisplatin, and 5-fluorouracil. The primary lesion in the esophagus achieved almost complete response as assessed by esophageal endoscopy. A computed tomography scan showed that the left ALM reduced in size and that stable disease was achieved for the right breast cancer. She underwent partial mastectomy of the right breast and bilateral axillary lymph node dissection. The histopathological diagnosis of the breast cancer was T1cN1M0 stage IIA. The lymph nodes from the left axilla contained metastatic cells from the squamous cell carcinoma of the esophagus. Complete response was achieved for the primary lesion in the esophagus following chemoradiotherapy (CRT), and the patient has been relapse free 2 years after treatment. Thus, we report the successful treatment of synchronous double cancers of the esophagus with left ALM and right breast by combination therapy with chemotherapy, CRT, and surgery.
authors.affiliation: Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan. yakiyama@iwate-med.ac.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Akiyama
authors.affiliation: Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan. tiwaya@iwate-med.ac.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iwaya
authors.affiliation: Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan. yoshioi@iwate-med.ac.jp.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Shioi
authors.affiliation: Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan. fumitakaendo@me.com.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Endo
authors.affiliation: Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan. kishiday08@gmail.com.
authors.forename: Kazushige
authors.initials: K
authors.lastname: Ishida
authors.affiliation: Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan. mkashiwa@iwate-med.ac.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kashiwaba
authors.affiliation: Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan. kokiotsu@iwate-med.ac.jp.
authors.forename: Koki
authors.initials: K
authors.lastname: Otsuka
authors.affiliation: Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan. hironitta@cyber.ocn.ne.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nitta
authors.affiliation: Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan. keikoeda@iwate-med.ac.jp.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Koeda
authors.affiliation: Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan. mmizuno@iwate-med.ac.jp.
authors.forename: Masaru
authors.initials: M
authors.lastname: Mizuno
authors.affiliation: Department of Palliative Care Medicine, Iwate Medical University School of Medicine, Iwate, Japan. ykimura@iwate-med.ac.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan. sakira@iwate-med.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Sasaki
keywords: Axillary lymph node metastasis; DCF therapy; Esophageal cancer; Synchronous double cancer