title: A novel disposable electrochemical sensor for determination of carbamazepine based on Fe doped SnO2 nanoparticles modified screen-printed carbon electrode.
abstract: An effective strategy to fabricate a novel disposable screen printing carbon electrode modified by iron doped tin dioxide nanoparticles for carbamazepine (CBZ) detection has been developed. Fe-SnO2 (Fe=0 to 5 wt.%) NPs were synthesized by a simple microwave irradiation method and assessed for their structural and morphological changes due to Fe doping into SnO2 matrix by X-ray diffraction and scanning and transmission electron microscopy. The electrochemical behaviour of carbamazepine at the Fe-SnO2 modified screen printed carbon electrode (SPCE) was investigated by cyclic voltammetry and square wave voltammetry. Electron transfer coefficient α (0.63) and electron transfer rate constant ks (0.69 s(-1)) values of the 5 wt.% Fe-SnO2 modified SPCE indicate that the diffusion controlled process takes place on the electrode surface. The fabricated sensor displayed a good electrooxidation response towards the detection of CBZ at a lower oxidation potential of 0.8 V in phosphate buffer solution at pH7.0. Under the optimal conditions, the sensor showed fast and sensitive current response to CBZ over a wide linear range of 0.5-100 μM with a low detection limit of 92 nM. Furthermore, the practical application of the modified electrode has been investigated by the determination of CBZ in pharmaceutical products using standard addition method.
authors.affiliation: Department of Biosensors and Bioelectronics, Alagappa University, Karaikudi 630003, TN, India; Department of Electronic Engineering, Chemistry and Materials Engineering, University of Messina, Messina 98166, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Lavanya
authors.affiliation: Department of Biosensors and Bioelectronics, Alagappa University, Karaikudi 630003, TN, India. Electronic address: Sekar2025@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Sekar
authors.affiliation: Department of Chemical Sciences, University of Messina, Messina 98166, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Ficarra
authors.affiliation: Department of Chemical Sciences, University of Messina, Messina 98166, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Tellone
authors.affiliation: Department of Electronic Engineering, Chemistry and Materials Engineering, University of Messina, Messina 98166, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bonavita
authors.affiliation: Department of Electronic Engineering, Chemistry and Materials Engineering, University of Messina, Messina 98166, Italy.
authors.forename: S G
authors.initials: SG
authors.lastname: Leonardi
authors.affiliation: Department of Electronic Engineering, Chemistry and Materials Engineering, University of Messina, Messina 98166, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Neri
mesh_terms: D002220:Carbamazepine / Q000032:analysis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D055664:Electrochemical Techniques; D004566:Electrodes; D007501:Iron / Q000737:chemistry*; D057230:Limit of Detection; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry; D017971:Tin Compounds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D004364:Pharmaceutical Preparations; D017971:Tin Compounds; D002220:Carbamazepine; D002244:Carbon; D007501:Iron; C045358:stannic oxide
keywords: Carbamazepine; Fe doped SnO(2) nanoparticles; Pharmaceutical products; Square wave voltammetry