title: Macrophages and HIV-1: An Unhealthy Constellation.
abstract: Lentiviruses have a long-documented association with macrophages. Abundant evidence exists for in vitro and, in a tissue-specific manner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV. However, macrophage contribution to aspects of HIV-1 and SIV pathogenesis, and their role in viral persistence in individuals on suppressive antiretroviral therapy, remains unclear. Here we discuss recent evidence implicating macrophages in HIV-1-mediated disease and highlight directions for further investigation.
authors.affiliation: The Sir William Dunn School of Pathology, The University of Oxford, Oxford OX13RE, UK. Electronic address: Quentin.sattentau@path.ox.ac.uk.
authors.forename: Quentin J
authors.initials: QJ
authors.lastname: Sattentau
authors.affiliation: Department of Medicine, University of Miami Miller School of Medicine, FL 33133, USA,. Electronic address: MStevenson@med.miami.edu.
authors.forename: Mario
authors.initials: M
authors.lastname: Stevenson
mesh_terms: D000818:Animals; D015658:HIV Infections / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008251:Macaca; D008264:Macrophages / Q000821:virology*; D008954:Models, Biological; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology / Q000821:virology; D015302:Simian Immunodeficiency Virus
keywords: HIV-1; macrophage; pathogenesis; reservoir