title: Subjective quality of life in first-episode psychosis. A ten year follow-up study.
abstract: Subjective quality of life (S-QoL) is an important outcome measure in first episode psychosis (FEP). The aims of this study were to describe S-QoL-development the first 10-years in FEP patients and to identify predictors of this development.
  
  
  METHODS
  A representative sample of 272 patients with a first episode psychotic disorder was included from 1997 through 2000. At 10 year follow-up 186 patients participated. QoL was measured by the Lehman's Quality of Life Interview. Linear mixed model analyses were performed to investigate longitudinal effects of baseline psychiatric symptoms and socio-economic variables and the effects of changes in the same variables on S-QoL-development.
  
  
  RESULTS
  S-QoL improved significantly over the follow-up period. More contact with family and a better financial situation at baseline had a positive and longstanding effect on S-QoL-development, but changes in these variables were not associated with S-QoL-development. Higher depressive symptoms and less daily activities at baseline both had a negative independent effect, but a positive interaction effect with time on S-QoL-development indicating that the independent negative effect diminished over time. In the change analysis, increased daily activities and a decrease in depressive symptoms were associated with a positive S-QoL-development.
  
  
  CONCLUSIONS
  Treatment of depressive symptoms and measures aimed at increasing daily activities seem important to improve S-QoL in patients with psychosis. More contact with family and a better financial situation at baseline have a long-standing effect on S-QoL-development in FEP patients.
authors.affiliation: Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway. Electronic address: e.s.gardsjord@medisin.uio.no.
authors.forename: Erlend Strand
authors.initials: ES
authors.lastname: Gardsjord
authors.affiliation: Division of Mental Health and Addiction, Oslo University Hospital, 0407 Oslo, Norway.
authors.forename: Kristin Lie
authors.initials: KL
authors.lastname: Romm
authors.affiliation: Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, 0407 Oslo, Norway.
authors.forename: Svein
authors.initials: S
authors.lastname: Friis
authors.affiliation: Women and Children's Division, Oslo University Hospital, 0407 Oslo, Norway.
authors.forename: Helene Eidsmo
authors.initials: HE
authors.lastname: Barder
authors.affiliation: Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway; Adult Psychiatric Department Vinderen, Diakonhjemmet Hospital, 0319 Oslo, Norway.
authors.forename: Julie
authors.initials: J
authors.lastname: Evensen
authors.affiliation: Early Psychosis Intervention Center, Psychiatry East-Region Zealand, 4000 Roskilde, Denmark; Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
authors.forename: Ulrik
authors.initials: U
authors.lastname: Haahr
authors.affiliation: Psychiatric Division, Network of Clinical Psychosis Research, Stavanger University Hospital, 4068 Stavanger, Norway.
authors.forename: Wenche
authors.initials: W
authors.lastname: ten Velden Hegelstad
authors.affiliation: Psychiatric Division, Network of Clinical Psychosis Research, Stavanger University Hospital, 4068 Stavanger, Norway; Faculty of Social Sciences, University of Stavanger, 4036 Stavanger, Norway.
authors.forename: Inge
authors.initials: I
authors.lastname: Joa
authors.affiliation: Psychiatric Division, Network of Clinical Psychosis Research, Stavanger University Hospital, 4068 Stavanger, Norway; Faculty of Social Sciences, University of Stavanger, 4036 Stavanger, Norway.
authors.forename: Jan Olav
authors.initials: JO
authors.lastname: Johannessen
authors.affiliation: Psychiatric Division, Network of Clinical Psychosis Research, Stavanger University Hospital, 4068 Stavanger, Norway.
authors.forename: Johannes
authors.initials: J
authors.lastname: Langeveld
authors.affiliation: Psychiatric Division, Network of Clinical Psychosis Research, Stavanger University Hospital, 4068 Stavanger, Norway; Department of Clinical Medicine, Section Psychiatry, University of Bergen, 5021 Bergen, Norway.
authors.forename: Tor Ketil
authors.initials: TK
authors.lastname: Larsen
authors.affiliation: Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway.
authors.forename: Stein
authors.initials: S
authors.lastname: Opjordsmoen
authors.affiliation: Department of Psychology, University of Oslo, P.O. 1094, Blindern, 0317 Oslo, Norway; Vestre Viken Hospital Trust, 3004 Drammen, Norway.
authors.forename: Bjørn Rishovd
authors.initials: BR
authors.lastname: Rund
authors.affiliation: Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Psychiatric Research Unit, Region Zealand, 4000 Roskilde, Denmark.
authors.forename: Erik
authors.initials: E
authors.lastname: Simonsen
authors.affiliation: Department of Behavioural Sciences in Medicine, University of Oslo, 0318 Oslo, Norway.
authors.forename: Per
authors.initials: P
authors.lastname: Vaglum
authors.affiliation: Department of Social and Behavioural Health, Yale School of Medicine, Yale University, New Haven, CT, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: McGlashan
authors.affiliation: Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, 0407 Oslo, Norway.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Melle
authors.affiliation: Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, 0407 Oslo, Norway.
authors.forename: Jan Ivar
authors.initials: JI
authors.lastname: Røssberg
mesh_terms: D000208:Acute Disease; D000328:Adult; D003863:Depression / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000453:epidemiology / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D012559:Schizophrenia / Q000453:epidemiology; D012565:Schizophrenic Psychology
keywords: Affective psychosis; First-episode psychosis; Follow-up; Quality of life; Schizophrenia