title: Solid-State Conformational Flexibility at Work: Zipping and Unzipping within a Cyclic Peptoid Single Crystal.
abstract: A peptidomimetic compound undergoes a reversible single-crystal-to-single-crystal transformation upon guest release/uptake with the transformation involving a drastic conformational change. The extensive and reversible alteration in the solid state is connected to the formation of an unprecedented "CH-π zipper" which can reversibly open and close (through the formation of CH-π interactions), thus allowing for guest sensing.
authors.affiliation: Dipartimento di Chimica e Biologia "A. Zambelli", Università degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano (SA), Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Meli
authors.affiliation: Dipartimento di Chimica e Biologia "A. Zambelli", Università degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano (SA), Italy.
authors.forename: Eleonora
authors.identifier: http://orcid.org/0000-0003-0251-901X
authors.initials: E
authors.lastname: Macedi
authors.affiliation: Dipartimento di Chimica e Biologia "A. Zambelli", Università degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano (SA), Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: De Riccardis
authors.affiliation: Department of Chemistry and Polymer Science, University of Stellenbosch, Private Bag X1, 7602, Matieland, Stellenbosch, South Africa.
authors.forename: Vincent J
authors.identifier: http://orcid.org/0000-0003-3546-3884
authors.initials: VJ
authors.lastname: Smith
authors.affiliation: Department of Chemistry and Polymer Science, University of Stellenbosch, Private Bag X1, 7602, Matieland, Stellenbosch, South Africa.
authors.forename: Leonard J
authors.identifier: http://orcid.org/0000-0002-6453-8331
authors.initials: LJ
authors.lastname: Barbour
authors.affiliation: Dipartimento di Chimica e Biologia "A. Zambelli", Università degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano (SA), Italy. iizzo@unisa.it.
authors.forename: Irene
authors.identifier: http://orcid.org/0000-0002-0369-0102
authors.initials: I
authors.lastname: Izzo
authors.affiliation: Dipartimento di Chimica e Biologia "A. Zambelli", Università degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano (SA), Italy. ctedesco@unisa.it.
authors.forename: Consiglia
authors.identifier: http://orcid.org/0000-0001-6849-798X
authors.initials: C
authors.lastname: Tedesco
keywords: crystal engineering; host-guest systems; noncovalent interactions; peptoids; supramolecular chemistry