title: Graft modification strategies to improve patency of prosthetic arteriovenous grafts for hemodialysis.
abstract: Prosthetic arteriovenous grafts (AVGs) are indicated for vascular access for long-term hemodialysis in patients in whom creation or maintenance of an arteriovenous fistula (AVF) has failed or is contraindicated. AVGs have an inferior long-term patency as compared to AVFs. To ameliorate patency rates of prosthetic AVGs, different strategies have emerged to improve graft materials. This review aims to describe current strategies and future perspectives on graft modification, by graft geometry, drug coatings and graft surface technology, to improve AVG patency.
authors.affiliation: Department of Vascular Surgery, Maastricht University Medical Center, Maastricht - The Netherlands.
authors.forename: Andrew
authors.initials: A
authors.lastname: Moufarrej
authors.affiliation: Department of Vascular Surgery, Maastricht University Medical Center, Maastricht - The Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: Tordoir
authors.affiliation: Department of Vascular Surgery, Maastricht University Medical Center, Maastricht - The Netherlands.|European Vascular Center Aachen-Maastricht, Maastricht - The Netherlands and Aachen - Germany.
authors.forename: Barend
authors.initials: B
authors.lastname: Mees
mesh_terms: D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects / Q000295:instrumentation*; D001783:Blood Flow Velocity; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation*; D002404:Catheterization; D020099:Coated Materials, Biocompatible; D006083:Graft Occlusion, Vascular / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D011474:Prosthesis Design; D011677:Punctures; D012039:Regional Blood Flow; D006435:Renal Dialysis; D012307:Risk Factors; D013499:Surface Properties; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency
chemical_list: D020099:Coated Materials, Biocompatible