title: Emerging Technologies to Prevent Pregnancy and Sexually Transmitted Infections in Women.
abstract: Worldwide, there continues to be a large unmet need for family planning and sexually transmitted infection (STI) prevention methods. Multipurpose prevention technology (MPT) is a general term encompassing any single prevention methodology targeting more than one STI (including HIV) and/or pregnancy. While innovation has been slow over the past several decades, recent scientific advances have resulted in new products entering clinical trials. This review focuses primarily on multipurpose technologies that are designed to prevent pregnancy and HIV. To examine the current state of MPTs, we outline key discoveries of biologic mechanisms that influence susceptibility of the female genital tract to HIV and STIs, and review the effects of hormonal contraception on HIV susceptibility. We discuss the state of currently available HIV prevention strategies for women, and their interactions with hormonal contraceptive products. Finally, we describe MPTs currently in preclinical and clinical trials and propose ongoing questions requiring research to help advance the field.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California.
authors.forename: Dominika
authors.initials: D
authors.lastname: Seidman
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California.
authors.forename: Anke
authors.initials: A
authors.lastname: Hemmerling
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California.
authors.forename: Karen
authors.initials: K
authors.lastname: Smith-McCune
mesh_terms: D003267:Contraception / Q000379:methods*; D005260:Female; D006801:Humans; D011247:Pregnancy; D049168:Pregnancy, Unplanned; D012749:Sexually Transmitted Diseases / Q000517:prevention & control*