title: Anion Recognition and Induced Self-Assembly of an α,γ-Cyclic Peptide To Form Spherical Clusters.
abstract: A cyclic octapeptide composed of hydroxy-functionalized γ-amino acids folds in a "V-shaped" conformation that allows the selective recognition of anions such as chloride, nitrate, and carbonate. The process involves the simultaneous self-assembly of six peptide subunits and the recognition of four anions to form a tetrahedral structure, in which the anions are located at the corners of the resulting structure. Each anion is coordinated to three different peptides. The structure was fully characterized by several techniques, including NMR spectroscopy and X-ray diffraction, and the material was able to facilitate the transmembrane transport of chloride ions.
authors.affiliation: Departamento de Química Orgánica and Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS), Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Rodríguez-Vázquez
authors.affiliation: Departamento de Química Orgánica and Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS), Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Amorín
authors.affiliation: Departamento de Química Biológica y Modelización Molecular, Instituto de Química Avanzada de Cataluña (IQAC-CSIC), Jordi Girona, 18-26, 08034, Barcelona, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Alfonso
authors.affiliation: Departamento de Química Orgánica and Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS), Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain. juanr.granja@usc.es.
authors.forename: Juan R
authors.identifier: http://orcid.org/0000-0002-5842-7504
authors.initials: JR
authors.lastname: Granja
keywords: anionrecognition; cyclic peptides; self-assembly; supramolecular chemistry; transport