title: Infiltrating spinal cord astrocytomas: Epidemiology, diagnosis, treatments and future directions.
abstract: Spinal cord gliomas, consisting mostly of ependymomas and astrocytomas, are rare entities. Of the gliomas, infiltrating astrocytomas are particularly challenging entities to treat due to their invasive nature. Surgical resection is oftentimes not possible without subjecting patients to permanent neurological deficits because of the difficulty in establishing clear tissue planes. As more is learned about the molecular genetics, genomics, and biology of these tumors, it is becoming more apparent that there are important differences between these tumors and their more common intracranial counterparts. There also appears to be important clinical differences between low-grade and high-grade astrocytomas. A multidisciplinary approach is needed to optimize the treatment of these difficult tumors.
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Muhammad M
authors.initials: MM
authors.lastname: Abd-El-Barr
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Kevin T
authors.initials: KT
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: jchi@partners.org.
authors.forename: John H
authors.initials: JH
authors.lastname: Chi
mesh_terms: D001254:Astrocytoma / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery
keywords: Infiltrating astrocytomas; Intramedullary spinal cord tumor; Literature review; Spinal cord neoplasms