title: Perfluoroalkyl substances in serum from South Korean infants with congenital hypothyroidism and healthy infants--Its relationship with thyroid hormones.
abstract: Exposure to perfluoroalkyl substances (PFASs) may disrupt thyroid systems, though the specific effects of PFASs are still being elucidated. Since research regarding exposure in infants is highly limited, our goal was to investigate exposure levels of PFASs in infant serum and correlate these levels with thyroid hormones (THs). This was accomplished by analyzing 16 PFASs in sera from a case group of infants with congenital hypothyroidism and a control group. Total PFAS exposure level was 2.63-44.7ng/mL in the case group and 2.44-22.4ng/mL in the control group. Concentrations of serum perfluorooctanoic acid (PFOA, p<0.01), perfluorononanoic acid (PFNA, p<0.001), perfluorooctanoic acid (PFDA, p<0.005), and perfluoroundecanoic acid (PFUnDA, p<0.005) were significantly higher in the case group than the control group. Levels of certain PFASs (PFOA, perfluorotridecanoic acid [PFTrDA], and perfluorohexane sulfonate [PFHxS]) showed a moderate to weak correlation with relevant antibodies.
authors.affiliation: Department of Civil and Environmental Engineering, Pusan National University, Busan, Republic of Korea.
authors.forename: Da-Hye
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Civil and Environmental Engineering, Pusan National University, Busan, Republic of Korea.
authors.forename: Un-Jung
authors.initials: UJ
authors.lastname: Kim
authors.affiliation: Department of Civil and Environmental Engineering, Pusan National University, Busan, Republic of Korea.
authors.forename: Hee-Young
authors.initials: HY
authors.lastname: Kim
authors.affiliation: School of Urban and Environmental Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
authors.forename: Sung-Deuk
authors.initials: SD
authors.lastname: Choi
authors.affiliation: Department of Civil and Environmental Engineering, Pusan National University, Busan, Republic of Korea. Electronic address: jeoh@pusan.ac.kr.
authors.forename: Jeong-Eun
authors.initials: JE
authors.lastname: Oh
mesh_terms: D016022:Case-Control Studies; D003409:Congenital Hypothyroidism / Q000097:blood* / Q000139:chemically induced; D005466:Fluorocarbons / Q000097:blood* / Q000633:toxicity; D006801:Humans; D007223:Infant; D056910:Republic of Korea; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D005466:Fluorocarbons; D013963:Thyroid Hormones
keywords: Congenital hypothyroidism; Infant; Perfluoroalkyl substances; Serum; South Korea