title: Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery.
abstract: We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaP-coating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery.
authors.affiliation: Center for Self-assembly and Complexity, Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
authors.forename: Hyung Woo
authors.initials: HW
authors.lastname: Choi
authors.affiliation: Center for Self-assembly and Complexity, Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
authors.forename: Jihoon
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Pohang University of Science and Technology (POSTECH) , Pohang 37673, Republic of Korea.
authors.forename: Jinhwan
authors.initials: J
authors.lastname: Kim
authors.affiliation: Center for Self-assembly and Complexity, Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
authors.forename: Yonghwi
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Biomedical Sciences, Seoul National University Graduate School , Seoul 03080, Republic of Korea.
authors.forename: Hyun Beom
authors.initials: HB
authors.lastname: Song
authors.affiliation: Department of Biomedical Sciences, Seoul National University Graduate School , Seoul 03080, Republic of Korea.
authors.forename: Jeong Hun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Center for Self-assembly and Complexity, Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.|Department of Chemistry, Pohang University of Science and Technology (POSTECH) , Pohang 37673, Republic of Korea.
authors.forename: Kimoon
authors.initials: K
authors.lastname: Kim
authors.affiliation: Center for Self-assembly and Complexity, Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.|Department of Chemistry, Pohang University of Science and Technology (POSTECH) , Pohang 37673, Republic of Korea.
authors.forename: Won Jong
authors.initials: WJ
authors.lastname: Kim
keywords: calcium phosphate; corneal wound healing; gatekeeper; nitric oxide delivery; pH-jump reagent