title: Helicobacter pylori and gut microbiota modulate energy homeostasis prior to inducing histopathological changes in mice.
abstract: Helicobacter pylori have been shown to influence physiological regulation of metabolic hormones involved in food intake, energy expenditure and body mass. It has been proposed that inducing H. pylori-induced gastric atrophy damages hormone-producing endocrine cells localized in gastric mucosal layers and therefore alter their concentrations. In a recent study, we provided additional proof in mice under controlled conditions that H. pylori and gut microbiota indeed affects circulating metabolic gut hormones and energy homeostasis. In this addendum, we presented data from follow-up investigations that demonstrated H. pylori and gut microbiota-associated modulation of metabolic gut hormones was independent and precedes H. pylori-induced histopathological changes in the gut of H. pylori-infected mice. Thus, H. pylori-associated argumentation of energy homeostasis is not caused by injury to endocrine cells in gastric mucosa.
authors.affiliation: a Department of Medical Microbiology , Faculty of Medicine, University of Malaya , Kuala Lumpur , Malaysia.
authors.forename: Yalda
authors.initials: Y
authors.lastname: Khosravi
authors.affiliation: b Duke-NUS Graduate Medical School , Singapore.
authors.forename: Ralph M
authors.initials: RM
authors.lastname: Bunte
authors.affiliation: c School of Chemical and Life Sciences, Singapore Polytechnic , Singapore.
authors.forename: Kher Hsin
authors.initials: KH
authors.lastname: Chiow
authors.affiliation: c School of Chemical and Life Sciences, Singapore Polytechnic , Singapore.
authors.forename: Tuan Lin
authors.initials: TL
authors.lastname: Tan
authors.affiliation: c School of Chemical and Life Sciences, Singapore Polytechnic , Singapore.
authors.forename: Whye Yen
authors.initials: WY
authors.lastname: Wong
authors.affiliation: c School of Chemical and Life Sciences, Singapore Polytechnic , Singapore.
authors.forename: Qian Hui
authors.initials: QH
authors.lastname: Poh
authors.affiliation: c School of Chemical and Life Sciences, Singapore Polytechnic , Singapore.
authors.forename: Ignatius Mario
authors.initials: IM
authors.lastname: Doli Sentosa
authors.affiliation: d National Cancer Center , Singapore.
authors.forename: Shih Wee
authors.initials: SW
authors.lastname: Seow
authors.affiliation: d National Cancer Center , Singapore.
authors.forename: Arlaine Anne
authors.initials: AA
authors.lastname: Amoyo
authors.affiliation: d National Cancer Center , Singapore.|e Department of Microbiology , Tumor and Cell Biology (MTC), Karolinska Institutet , Stockholm , Sweden.|f LKC School of Medicine, Nanyang Technological University , Singapore.
authors.forename: Sven
authors.initials: S
authors.lastname: Pettersson
authors.affiliation: a Department of Medical Microbiology , Faculty of Medicine, University of Malaya , Kuala Lumpur , Malaysia.
authors.forename: Mun Fai
authors.initials: MF
authors.lastname: Loke
authors.affiliation: a Department of Medical Microbiology , Faculty of Medicine, University of Malaya , Kuala Lumpur , Malaysia.
authors.forename: Jamuna
authors.initials: J
authors.lastname: Vadivelu
mesh_terms: D000818:Animals; D004734:Energy Metabolism; D005753:Gastric Mucosa / Q000378:metabolism* / Q000382:microbiology; D000069196:Gastrointestinal Microbiome; D054439:Ghrelin / Q000378:metabolism; D016481:Helicobacter Infections / Q000382:microbiology; D016480:Helicobacter pylori / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D051379:Mice; D019894:Peptide YY / Q000378:metabolism
chemical_list: D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D019894:Peptide YY
keywords: H. pylori; crosstalk; germ-free mice; microbiota; specific pathogen-free mice