title: Disruptions of Sleep/Wake Patterns in the Stable Tubule Only Polypeptide (STOP) Null Mouse Model of Schizophrenia.
abstract: Disruption of sleep/wake cycles is common in patients with schizophrenia and correlates with cognitive and affective abnormalities. Mice deficient in stable tubule only polypeptide (STOP) show cognitive, behavioral, and neurobiological deficits that resemble those seen in patients with schizophrenia, but little is known about their sleep phenotype. We characterized baseline sleep/wake patterns and recovery sleep following sleep deprivation in STOP null mice. Polysomnography was conducted in adult male STOP null and wild-type (WT) mice under a 12:12 hours light:dark cycle before, during, and after 6 hours of sleep deprivation during the light phase. At baseline, STOP null mice spent more time awake and less time in non-rapid eye movement sleep (NREMS) over a 24-hour period, with more frequent transitions between wake and NREMS, compared to WT mice, especially during the dark phase. The distributions of wake, NREMS and REMS across the light and the dark phases differed by genotype, and so did features of the electroencephalogram (EEG). Following sleep deprivation, both genotypes showed homeostatic increases in sleep duration, with no significant genotype differences in the initial compensatory increase in sleep intensity (EEG delta power). These results indicate that STOP null mice sleep less overall, and their sleep and wake periods are more fragmented than those of WT mice. These features in STOP null mice are consistent with the sleep patterns observed in patients with schizophrenia.
authors.affiliation: Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada;
authors.forename: Maxine F
authors.initials: MF
authors.lastname: Profitt
authors.affiliation: Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada;
authors.forename: Samuel
authors.initials: S
authors.lastname: Deurveilher
authors.affiliation: Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada;
authors.forename: George S
authors.initials: GS
authors.lastname: Robertson
authors.affiliation: Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada; Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Rusak
authors.affiliation: Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada semba@dal.ca.
authors.forename: Kazue
authors.initials: K
authors.lastname: Semba
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D017286:Polysomnography; D012559:Schizophrenia / Q000503:physiopathology*; D012892:Sleep Deprivation; D012894:Sleep Stages / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
chemical_list: D008869:Microtubule-Associated Proteins; C491893:Mtap6 protein, mouse
keywords: microtubule-associated protein; polysomnography; rodent model; sleep and wake states; sleep homeostasis