title: Diagnostic value of serum procalcitonin, neopterin, and gamma interferon in neonatal calves with septicemic colibacillosis.
abstract: The objective of our study was to compare the serum concentrations of procalcitonin (PCT), neopterin, tumor necrosis factor alpha (TNF-α), prostaglandin E2, malondialdehyde, interleukin 8, and gamma interferon (IFN-γ) in neonatal calves with septicemic colibacillosis (n = 15) with healthy controls (n = 15). Septicemic colibacillosis was diagnosed based on clinical signs and the isolation of Escherichia coli from heparinized blood in clinically suspected cases. PCT, neopterin, TNF-α (p < 0.05), and IFN-γ concentrations in calves with septicemic colibacillosis were significantly higher than in the healthy controls (p < 0.01). Serum PCT concentrations were ~4 times higher in the calves with septicemic colibacillosis than in the healthy calves, suggesting that PCT could be a useful marker of septicemic colibacillosis in neonatal calves.
authors.affiliation: Departments of Biochemistry (Ercan), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyInternal Medicine (Başbug), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyPathology (Tuzcu), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyDepartment of Pharmaceutical Microbiology, Cumhuriyet University, Faculty of Pharmacy, Sivas, Turkey (Tuzcu, Alim) nazliercan@yahoo.com.
authors.forename: Nazli
authors.initials: N
authors.lastname: Ercan
authors.affiliation: Departments of Biochemistry (Ercan), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyInternal Medicine (Başbug), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyPathology (Tuzcu), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyDepartment of Pharmaceutical Microbiology, Cumhuriyet University, Faculty of Pharmacy, Sivas, Turkey (Tuzcu, Alim).
authors.forename: Nevin
authors.initials: N
authors.lastname: Tuzcu
authors.affiliation: Departments of Biochemistry (Ercan), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyInternal Medicine (Başbug), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyPathology (Tuzcu), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyDepartment of Pharmaceutical Microbiology, Cumhuriyet University, Faculty of Pharmacy, Sivas, Turkey (Tuzcu, Alim).
authors.forename: Onur
authors.initials: O
authors.lastname: Başbug
authors.affiliation: Departments of Biochemistry (Ercan), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyInternal Medicine (Başbug), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyPathology (Tuzcu), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyDepartment of Pharmaceutical Microbiology, Cumhuriyet University, Faculty of Pharmacy, Sivas, Turkey (Tuzcu, Alim).
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tuzcu
authors.affiliation: Departments of Biochemistry (Ercan), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyInternal Medicine (Başbug), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyPathology (Tuzcu), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyDepartment of Pharmaceutical Microbiology, Cumhuriyet University, Faculty of Pharmacy, Sivas, Turkey (Tuzcu, Alim).
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alim
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D016470:Bacteremia / Q000097:blood / Q000662:veterinary; D015415:Biomarkers / Q000097:blood*; D002116:Calcitonin / Q000097:blood; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000175:diagnosis*; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000097:blood / Q000662:veterinary*; D007371:Interferon-gamma / Q000097:blood; D019798:Neopterin / Q000097:blood; D011498:Protein Precursors / Q000097:blood
chemical_list: D015415:Biomarkers; D011498:Protein Precursors; D019798:Neopterin; D007371:Interferon-gamma; D002116:Calcitonin
keywords: Colibacillosis; neonatal calves; procalcitonin; septicemia