title: Total testosterone levels are correlated to metabolic syndrome components.
abstract: BACKGROUND
  Metabolic syndrome (MetS) is a constellation of interrelated risk factors of metabolic origin. Some studies suggest a possible link between low total testosterone (TT) levels and the presence of MetS.
  
  
  OBJECTIVE
  To analyze the strength and independence of associations between TT and MetS components in non-diabetic men.
  
  
  METHODS
  In this cross-sectional study, 143 non-diabetic men older than 40 were analyzed.
  
  
  METHODS
  Blood samples were collected to evaluate metabolic profile and TT levels. MetS was defined as the presence of three or more of the following characteristics: fasting blood glucose levels ≥ 100 mg/dL, triglyceride ≥ 150 mg/dL, HDL-c < 40 mg/dL, hypertension or blood pressure ≥ 130/85 mmHg, and waist girth > 102 cm.
  
  
  RESULTS
  Mean age of the study population was 61.5 ± 8.61 years old. MetS was present in 47.9% of the individuals. Thirty-four men had low TT and MetS was observed in 23 (70%) against 50 (46%) in those with normal TT (≥ 300 ng/dL) (OR 4.94, p < 0.01), adjusted to confounder's factors. In multiple linear regression analysis, only waist circumference (Beta: -0.395; p = 0.03) and HDL-c (Beta: 0.19; p = 0.04) remained significantly correlated with TT levels.
  
  
  CONCLUSIONS
  Low TT levels were associated with MetS diagnosis. Abdominal obesity was the MetS component independently correlated to low TT levels.
authors.affiliation: a Post-Graduating Course of Medical Sciences, Universidade Federal De Ciências Da Saúde De Porto Alegre (UFCSPA), Urologist at Irmandade Santa Casa De Porto Alegre (ISCMPA) and Hospital Moinhos De Vento De Porto Alegre (HMV) , Porto Alegre , RS , Brazil .
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Blaya
authors.affiliation: b UFCSPA , Porto Alegre , RS , Brazil .
authors.forename: Leonardo Dalla Giacomassa Rocha
authors.initials: LD
authors.lastname: Thomaz
authors.affiliation: b UFCSPA , Porto Alegre , RS , Brazil .
authors.forename: Fernanda
authors.initials: F
authors.lastname: Guilhermano
authors.affiliation: b UFCSPA , Porto Alegre , RS , Brazil .
authors.forename: Artur de Oliveira
authors.initials: Ade O
authors.lastname: Paludo
authors.affiliation: c Universidade Católica De Pelotas (UCPel) , Pelotas , RS , Brazil .
authors.forename: Luiza
authors.initials: L
authors.lastname: Rhoden
authors.affiliation: d UFCSPA, Centro Universitário Ritter Dos Reis (UniRitter) , Porto Alegre , RS , Brazil , and.
authors.forename: Graziele
authors.initials: G
authors.lastname: Halmenschlager
authors.affiliation: e UFCSPA, Urologist at ISCMPA and HMV , Porto Alegre , RS , Brazil.
authors.forename: Ernani Luis
authors.initials: EL
authors.lastname: Rhoden
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D013739:Testosterone / Q000097:blood* / Q000172:deficiency; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides; D013739:Testosterone
keywords: Testosterone; abdominal obesity; hypogonadism; insulin resistance; metabolic syndrome X; waist circumference