title: Precise identification of immunotherapeutic targets for solid malignancies using clues within the tumor microenvironment-Evidence to turn on the LIGHT.
abstract: Targeted immunotherapy for solid gastrointestinal malignancies is challenging due to a lack of identified tumor antigens. Therefore, a strategy that supports and expands tumor infiltrating lymphocytes in the tumor microenvironment may allow these tumor-reactive T-cells to incite an antitumor response. Gene expression analysis of colon metastases has identified specific immunotherapeutic targets for this malignancy.
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Department of Microbiology and Immunology, University of Illinois at Chicago , Chicago, IL, USA.
authors.forename: Ajay V
authors.initials: AV
authors.lastname: Maker
keywords: Colon cancer; LIGHT; Tnfsf14; gastrointestinal cancers; immunotherapy; metastasis; tumor infiltrating lymphocytes; tumor microenvironment