title: Association between Tooth Loss and Gastric Cancer: A Meta-Analysis of Observational Studies.
abstract: Observational studies showed that tooth loss is associated with gastric cancer, but the findings are inconsistent. In this study, a meta-analysis was conducted to evaluate the relationship between tooth loss and gastric cancer. Relevant studies were screened in PubMed and Embase databases, and nine observational studies were considered eligible for the analysis. The combined relative risks for the highest versus the lowest categories of tooth loss were 1.86 (95% CI: 1.08-3.21) and 1.31 (95% CI: 1.12-1.53) in case control and cohort studies, respectively. However, unstable results were observed in the stratified and sensitivity analysis. The current evidence, based solely on four case-control studies and five cohort studies, suggested that tooth loss is a potential marker of gastric cancer. However, we can not concluded at this time that tooth loss may be a risk factor for gastric cancer due to significant heterogeneity among studies and mixed results between case-control studies and cohort studies. Additional large-scale and high-quality prospective studies are required to evaluate the association between tooth loss and risk of gastric cancer.
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou Provincial People's hospital, Guiyang, China.
authors.forename: Xin-Hai
authors.initials: XH
authors.lastname: Yin
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou Provincial People's hospital, Guiyang, China.
authors.forename: Ya-Dong
authors.initials: YD
authors.lastname: Wang
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou Provincial People's hospital, Guiyang, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Luo
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou Provincial People's hospital, Guiyang, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhao
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou Provincial People's hospital, Guiyang, China.
authors.forename: Guang-Lei
authors.initials: GL
authors.lastname: Huang
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou Provincial People's hospital, Guiyang, China.
authors.forename: Si-Yang
authors.initials: SY
authors.lastname: Luo
authors.affiliation: Department of Orthodontics, Stomatology hospital of Gui yang, Guiyang, China.
authors.forename: Ju-Xiang
authors.initials: JX
authors.lastname: Peng
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou Provincial People's hospital, Guiyang, China.
authors.forename: Ju-Kun
authors.initials: JK
authors.lastname: Song
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D064887:Observational Studies as Topic; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology*; D016388:Tooth Loss / Q000150:complications*