title: Energy-dependent effects of resveratrol in Saccharomyces cerevisiae.
abstract: The metabolic effects induced by resveratrol have been associated mainly with the consumption of high-calorie diets; however, its effects with standard or low-calorie diets remain unclear. To better understand the interactions between resveratrol and cellular energy levels, we used Saccharomyces cerevisiae as a model. Herein it is shown that resveratrol: (a) decreased cell viability in an energy-dependent manner; (b) lessening of cell viability occurred specifically when cells were under cellular respiration; and (c) inhibition of oxygen consumption in state 4 occurred at low and standard energy levels, whereas at high energy levels oxygen consumption was promoted. These findings indicate that the effects of resveratrol are dependent on the cellular energy status and linked to metabolic respiration. Importantly, our study also revealed that S. cerevisiae is a suitable and useful model to elucidate the molecular targets of resveratrol under different nutritional statuses. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Laboratorio de Biotecnología Microbiana del Instituto Tecnológico Superior de Ciudad Hidalgo, Michoacán, México.|Universidad Autónoma de Querétaro, Santiago de Querétaro, Qro, México.
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: Madrigal-Perez
authors.affiliation: Laboratorio de Biotecnología Microbiana del Instituto Tecnológico Superior de Ciudad Hidalgo, Michoacán, México.
authors.forename: Melina
authors.initials: M
authors.lastname: Canizal-Garcia
authors.affiliation: Laboratorio de Bioquímica del Instituto Tecnológico de Morelia, Michoacán, México.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: González-Hernández
authors.affiliation: Universidad Autónoma de Querétaro, Santiago de Querétaro, Qro, México.
authors.forename: Rosalia
authors.initials: R
authors.lastname: Reynoso-Camacho
authors.affiliation: Universidad Autónoma de Querétaro, Santiago de Querétaro, Qro, México.
authors.forename: Gerardo M
authors.initials: GM
authors.lastname: Nava
authors.affiliation: Universidad Autónoma de Querétaro, Santiago de Querétaro, Qro, México.
authors.forename: Minerva
authors.initials: M
authors.lastname: Ramos-Gomez
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D010101:Oxygen Consumption; D000077185:Resveratrol; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism*; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013267:Stilbenes; D000077185:Resveratrol