title: New Chiral Reagent for Installation of Pharmacophoric (S)- or (R)-2-(Alkoxyphosphono)-1-amino-2,2-difluoroethyl Groups.
abstract: A new chiral reagent has been developed for generalized installation of pharmacophoric (S)- or (R)-2-(alkoxyphosphono)-1-amino-2,2-difluoroethyl group into organic compounds. The original synthetic application of this new reagent is exemplified by Friedel-Crafts reactions with indoles, which proceed efficiently with excellent diastereoselectivity to give enantiomerically pure products.
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, P. R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xie
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, P. R. China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, P. R. China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Mei
authors.affiliation: Department of Life Sciences and Chemistry, Jacobs University Bremen gGmbH, 28759, Bremen, Germany.
authors.forename: Romana
authors.initials: R
authors.lastname: Pajkert
authors.affiliation: Department of Life Sciences and Chemistry, Jacobs University Bremen gGmbH, 28759, Bremen, Germany.
authors.forename: Maksym
authors.initials: M
authors.lastname: Ponomarenko
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of Life Sciences and Chemistry, Jacobs University Bremen gGmbH, 28759, Bremen, Germany. g.roeschenthaler@jacobs-university.de.
authors.forename: Gerd-Volker
authors.initials: GV
authors.lastname: Röschenthaler
authors.affiliation: Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018, San Sebastián, Spain. vadym.soloshonok@ehu.es.|IKERBASQUE, Basque Foundation for Science, Alameda Urquijo 36-5, Plaza Bizkaia, 48011, Bilbao, Spain. vadym.soloshonok@ehu.es.
authors.forename: Vadim A
authors.initials: VA
authors.lastname: Soloshonok
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, P. R. China. hanjl@nju.edu.cn.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Han
keywords: Friedel-Crafts; asymmetric synthesis; imine; indoles; synthetic methods