title: Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course.
abstract: The incidence of malignant melanoma in the developed world is continuously increasing. We conducted a case-control study in order to evaluate the association between each of the four estrogen receptor alpha polymorphisms (ESR1 single-nucleotide polymorphisms [SNPs] +2464C/T, -4576A/C, +1619A/G, and +6362C/T) and malignant melanoma susceptibility and disease course. The study population consisted of 205 Caucasian patients who were diagnosed as having malignant melanoma and 208 healthy Caucasian controls. Through DNA genotyping, we identified a SNP-dependent malignant melanoma susceptibility as well as a SNP-dependent effect on the course of disease and response to therapy.
authors.affiliation: Trauma and Hand Surgery, St. Vincentius Hospital Karlsruhe, Germany.
authors.forename: Hanna
authors.initials: H
authors.lastname: Glatthaar
authors.affiliation: Biologist, José Carreras Center for Immuno and Gene Therapy, University of Saarland, Homburg/Saar, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Katto
authors.affiliation: Clinical Director of Dermatology, University Hospital of Homburg/Saar, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Vogt
authors.affiliation: Chief Physician Medicine/Oncology, St. Lukas Hospital Solingen, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Mahlknecht
keywords: ESR1; SNP; estrogen receptor; malignant melanoma