title: Hourly analysis of cerebrospinal fluid glucose shows large diurnal fluctuations.
abstract: Cerebrospinal fluid analysis is important in the diagnostics of many neurological disorders. Since the influence of food intake on the cerebrospinal fluid glucose concentration and the cerebrospinal fluid/plasma glucose ratio is largely unknown, we studied fluctuations in these parameters in healthy adult volunteers during a period of 36 h. Our observations show large physiological fluctuations of cerebrospinal fluid glucose and the cerebrospinal fluid/plasma glucose ratio, and their relation to food intake. These findings provide novel insights into the physiology of cerebral processes dependent on glucose levels such as energy formation (e.g. glycolysis), enzymatic reactions (e.g. glycosylation), and non-enzymatic reactions (e.g. advanced endproduct glycation).
authors.affiliation: Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlandsv Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands marcel.verbeek@radboudumc.nl.
authors.forename: Marcel M
authors.initials: MM
authors.lastname: Verbeek
authors.affiliation: Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlandsv Department of Pediatric Neurology, Radboud University Medical Center, Nijmegen, The Netherlands Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Wilhelmina G
authors.initials: WG
authors.lastname: Leen
authors.affiliation: Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlandsv Department of Pediatric Neurology, Radboud University Medical Center, Nijmegen, The Netherlands Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Michèl A
authors.initials: MA
authors.lastname: Willemsen
authors.affiliation: Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Diane
authors.initials: D
authors.lastname: Slats
authors.affiliation: Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Jurgen A
authors.initials: JA
authors.lastname: Claassen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002555:Cerebrospinal Fluid / Q000737:chemistry* / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D004435:Eating / Q000502:physiology; D005260:Female; D005947:Glucose / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D013997:Time Factors
chemical_list: D005947:Glucose
keywords: Cerebrospinal fluid; diurnal; glucose; glucose transport; plasma