title: Lnc-SGK1 induced by Helicobacter pylori infection and highsalt diet promote Th2 and Th17 differentiation in human gastric cancer by SGK1/Jun B signaling.
abstract: Serum and glucocorticoid-inducible kinase (SGK) 1can be triggered in several malignancies. Most research on SGK1has focused on its role in cancer cells, and we sought to investigate its potential upstream non-coding RNA nominated as Lnc-SGK1, and their expression and diagnostic value in T cells in human gastric cancer (GC). Excessive expression of Lnc-SGK1 and SGK1 were observed in T cell either within the tumor or peripheral T cells, and furthermore associated with Helicobacter pylori infection and high-salt diet (HSD). Within T cells, Helicobacter pylori (Hp) infection and high-salt dietcan up-regulated SGK1 expression and in turn enhance expression of Lnc-SGK1 through JunB activation. And expression of Lnc-SGK1 can further enhance transcription of SGK1 through cis regulatory mode. Lnc-SGK1 can induce Th2 and Th17 and reduce Th1 differentiation via SGK1/JunB signaling. Serum Lnc-SGK1 expression in combination with H. pylori infection and/or HSD in T cells was associated with poor prognosis of GC patients, and could be an ideal diagnostic index in human GC.
authors.affiliation: Department of Clinical Laboratory, The First People's Hospital of Kunshan, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Clinical Laboratory, The Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China.
authors.forename: Qingbo
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Department of Clinical Laboratory, Wujin Hospital Affiliated to Jiangsu University, Changzhou, Jiangsu, China.
authors.forename: Lixing
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Clinical Laboratory, The First People's Hospital of Kunshan, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Clinical Laboratory, The First People's Hospital of Kunshan, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
authors.forename: Qinghui
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Clinical Laboratory, The First People's Hospital of Kunshan, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory, The First People's Hospital of Kunshan, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
authors.forename: Huang
authors.initials: H
authors.lastname: Feng
authors.affiliation: Department of Clinical Laboratory, The First People's Hospital of Kunshan, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
authors.forename: Panpan
authors.initials: P
authors.lastname: Zang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D002454:Cell Differentiation; D002478:Cells, Cultured; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000187:drug effects / Q000821:virology; D016481:Helicobacter Infections / Q000150:complications* / Q000821:virology; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D017874:Immediate-Early Proteins / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D022661:RNA, Untranslated / Q000235:genetics*; D015398:Signal Transduction; D017673:Sodium Chloride, Dietary / Q000009:adverse effects*; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000473:pathology* / Q000821:virology; D015996:Survival Rate; D058504:Th17 Cells / Q000187:drug effects / Q000473:pathology* / Q000821:virology; D018418:Th2 Cells / Q000187:drug effects / Q000473:pathology* / Q000821:virology; D000099184:Serum-Glucocorticoid Regulated Kinases
chemical_list: D014408:Biomarkers, Tumor; D017874:Immediate-Early Proteins; D017346:Protein Serine-Threonine Kinases; D016755:Proto-Oncogene Proteins c-jun; D022661:RNA, Untranslated; D017673:Sodium Chloride, Dietary; D000099184:Serum-Glucocorticoid Regulated Kinases
keywords: Helicobacter pylori infection; LncRNA; gastric cancer; high-salt diet; serum and glucocorticoid-inducible kinase