title: HSC Fate Is Tethered to Mitochondria.
abstract: Mitochondria play important roles in homeostasis of hematopoietic stem cells (HSCs), which exhibit clonal heterogeneity in their lymphoid and myeloid production. Recently in Nature, Luchsinger et al. (2016) showed that mitochondria-ER tethering maintains lymphoid-biased HSCs through calcium-dependent NFAT signaling, providing molecular insights into the basis of HSC heterogeneity.
authors.affiliation: Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Lauren P
authors.initials: LP
authors.lastname: Diebold
authors.affiliation: Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: nav@northwestern.edu.
authors.forename: Navdeep S
authors.initials: NS
authors.lastname: Chandel
mesh_terms: D000818:Animals; D005260:Female; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism*; D008214:Lymphocytes / Q000166:cytology*; D008297:Male
chemical_list: D020558:GTP Phosphohydrolases