title: First report of Lividin and Spinulosain peptides from the skin secretion of an Indian frog.
abstract: Here, we report two novel peptides identified from the skin secretion, having homologies to Lividin and Spinulosain, of an endemic frog, Hydrophylax bahuvistara, of Western Ghats. This is the first report of these peptides from Indian frogs and first identification of Lividin from the Hydrophylax genus. Both peptides exhibited weak antimicrobial activity but very low haemolytic activity. The problems of naming amphibian host defense peptides (HDPs) are also discussed.
authors.affiliation: Molecular Ecology Laboratory, Rajiv Gandhi Centre for Biotechnology , Thiruvananthapuram-695014, Kerala , India.
authors.forename: Thundiparampil V
authors.initials: TV
authors.lastname: Vineeth Kumar
authors.affiliation: Molecular Ecology Laboratory, Rajiv Gandhi Centre for Biotechnology , Thiruvananthapuram-695014, Kerala , India.
authors.forename: Shyla
authors.initials: S
authors.lastname: Gopal
authors.affiliation: Molecular Ecology Laboratory, Rajiv Gandhi Centre for Biotechnology , Thiruvananthapuram-695014, Kerala , India.
authors.forename: Sanil
authors.initials: S
authors.lastname: George
mesh_terms: D029845:Amphibian Proteins / Q000032:analysis* / Q000737:chemistry; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000032:analysis* / Q000737:chemistry; D012634:Bodily Secretions / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D011898:Ranidae; D012867:Skin / Q000378:metabolism*
chemical_list: D029845:Amphibian Proteins; D023181:Antimicrobial Cationic Peptides; C000607825:lividin, Hydrophylax bahuvistara; C000607826:spinulosain, Hydrophylax bahuvistara
keywords: Hylarana; Lividin; Spinulosain; antimicrobial; nomenclature