title: Metallomics approach to changes in element concentration during differentiation from fibroblasts into adipocytes by element array analysis.
abstract: We aimed to establish an element array analysis that involves the simultaneous detection of all elements in cells and the display of changes in element concentration before and after a cellular event. In this study, we demonstrated changes in element concentration during the differentiation of 3T3-L1 mouse fibroblasts into adipocytes. This metallomics approach yielded unique information of cellular response to physiological and toxicological events.
authors.affiliation: Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University.
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Ogra
authors.forename: Shu
authors.initials: S
authors.lastname: Nagasaki
authors.forename: Ayako
authors.initials: A
authors.lastname: Yawata
authors.forename: Yasumi
authors.initials: Y
authors.lastname: Anan
authors.forename: Koichi
authors.initials: K
authors.lastname: Hamada
authors.forename: Akihiro
authors.initials: A
authors.lastname: Mizutani
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology* / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation; D004602:Elements; D005347:Fibroblasts / Q000166:cytology* / Q000378:metabolism*; D020342:Finite Element Analysis; D055432:Metabolomics / Q000379:methods*; D008670:Metals / Q000378:metabolism*; D051379:Mice
chemical_list: D004602:Elements; D008670:Metals