title: Ceftaroline fosamil treatment outcomes compared with standard of care among hospitalized patients with complicated skin and soft tissue infections.
abstract: Compare clinical and cost outcomes associated with ceftaroline fosamil with other commonly used antibiotics in complicated skin and soft tissue infections.
  
  
  
  Retrospective analysis of hospital records from 2010 to 2013 in Premier's Perspective comparative database for adults with complicated skin and soft tissue infection treated with intravenous ceftaroline fosamil, vancomycin, daptomycin, linezolid or tigecycline. Length of stay, inpatient costs and mortality were compared between propensity score-matched treatment groups.
  
  
  
  Compared with the other commonly used antibiotics, matched patients in the ceftaroline fosamil treatment group had an equivalent (1%) or lower (compared with linezolid, 2%) in-hospital mortality rate, and significantly lower (p < 0.001) average unadjusted and regression-adjusted length of stay and inpatient costs (savings of $3398.80 compared with daptomycin).
authors.affiliation: AstraZeneca, Gaithersburg, MD, USA.
authors.forename: Sudeep
authors.initials: S
authors.lastname: Karve
authors.affiliation: AstraZeneca, Gaithersburg, MD, USA.
authors.forename: Judith
authors.initials: J
authors.lastname: Hackett
authors.affiliation: AstraZeneca, Gaithersburg, MD, USA.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Levinson
authors.affiliation: Wickenstones, Oxford, UK.
authors.forename: Edward
authors.initials: E
authors.lastname: Gibson
authors.affiliation: Wickenstones, Oxford, UK.
authors.forename: Alysia
authors.initials: A
authors.lastname: Battersby
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D006801:Humans; D012189:Retrospective Studies; D018461:Soft Tissue Infections / Q000188:drug therapy*; D059039:Standard of Care; D016896:Treatment Outcome; D000097583:Ceftaroline
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000097583:Ceftaroline
keywords: ceftaroline fosamil; complicated skin and soft tissue infection; economic evaluation; patient registry