title: Metachronous primary uterine cancer surgically resected during Crizotinib treatment in a ALK-rearranged advanced lung adenocarcinoma.
abstract: Rearrangements of the anaplastic lymphoma kinase (ALK) gene are present in 3% to 7% of non-small-cell lung cancers (NSCLCs). Patients harboring ALK rearrangements show very favourable outcomes if treated with targeted agents, among which crizotinib is the first and best studied. Crizotinib, an oral small-molecule tyrosine kinase inhibitor of ALK, MET, and ROS1 kinases, is a very active and well tolerated drug. Nevertheless, the optimal therapy management with this new drug is still partially unknown, especially with regard to the safety of combined treatments. Recently, the integration of locoregional treatments has been proposed as a feasible multimodality strategy in selected patients with good clinical conditions and slow-growing or oligoprogressive disease. In this report, a case of advanced lung adenocarcinoma, progressed after first line chemotherapy and re-biopsied detecting ALK rearrangement, is described. During crizotinib treatment the primary lung tumor showed an excellent regression; meanwhile a major surgery for a metachronous uterine cancer was safely and successfully carried out.
authors.affiliation: 1 Medical Oncology Unit, 2 Pathology Department, Clinical Cancer Center Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco 65, Bari 70124, Italy ; 3 Pathology Department, DETO, University of Bari, Piazza Giulio Cesare, Bari 70124, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Catino
authors.affiliation: 1 Medical Oncology Unit, 2 Pathology Department, Clinical Cancer Center Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco 65, Bari 70124, Italy ; 3 Pathology Department, DETO, University of Bari, Piazza Giulio Cesare, Bari 70124, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Misino
authors.affiliation: 1 Medical Oncology Unit, 2 Pathology Department, Clinical Cancer Center Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco 65, Bari 70124, Italy ; 3 Pathology Department, DETO, University of Bari, Piazza Giulio Cesare, Bari 70124, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Scattone
authors.affiliation: 1 Medical Oncology Unit, 2 Pathology Department, Clinical Cancer Center Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco 65, Bari 70124, Italy ; 3 Pathology Department, DETO, University of Bari, Piazza Giulio Cesare, Bari 70124, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Caldarola
authors.affiliation: 1 Medical Oncology Unit, 2 Pathology Department, Clinical Cancer Center Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco 65, Bari 70124, Italy ; 3 Pathology Department, DETO, University of Bari, Piazza Giulio Cesare, Bari 70124, Italy.
authors.forename: Stella
authors.initials: S
authors.lastname: Petroni
authors.affiliation: 1 Medical Oncology Unit, 2 Pathology Department, Clinical Cancer Center Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco 65, Bari 70124, Italy ; 3 Pathology Department, DETO, University of Bari, Piazza Giulio Cesare, Bari 70124, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Logroscino
authors.affiliation: 1 Medical Oncology Unit, 2 Pathology Department, Clinical Cancer Center Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco 65, Bari 70124, Italy ; 3 Pathology Department, DETO, University of Bari, Piazza Giulio Cesare, Bari 70124, Italy.
authors.forename: Elisabetta Sara
authors.initials: ES
authors.lastname: Montagna
authors.affiliation: 1 Medical Oncology Unit, 2 Pathology Department, Clinical Cancer Center Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco 65, Bari 70124, Italy ; 3 Pathology Department, DETO, University of Bari, Piazza Giulio Cesare, Bari 70124, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Serio
authors.affiliation: 1 Medical Oncology Unit, 2 Pathology Department, Clinical Cancer Center Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco 65, Bari 70124, Italy ; 3 Pathology Department, DETO, University of Bari, Piazza Giulio Cesare, Bari 70124, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Simone
authors.affiliation: 1 Medical Oncology Unit, 2 Pathology Department, Clinical Cancer Center Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco 65, Bari 70124, Italy ; 3 Pathology Department, DETO, University of Bari, Piazza Giulio Cesare, Bari 70124, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Galetta
keywords: ALK rearrangement; Crizotinib therapy; Re-biopsy; major surgery; metachronous uterine cancer