title: Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease.
abstract: Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.
authors.affiliation: Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385, France Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology.
authors.forename: Amanda Farage
authors.initials: AF
authors.lastname: Frade
authors.affiliation: Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385, France.
authors.forename: Laurie
authors.initials: L
authors.lastname: Laugier
authors.affiliation: Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology University of Santo Amaro, São Paulo, Brazil.
authors.forename: Ludmila Rodrigues Pinto
authors.initials: LR
authors.lastname: Ferreira
authors.affiliation: Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology.
authors.forename: Monique Andrade
authors.initials: MA
authors.lastname: Baron
authors.affiliation: Division of Pathology.
authors.forename: Luiz Alberto
authors.initials: LA
authors.lastname: Benvenuti
authors.affiliation: Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology.
authors.forename: Priscila Camillo
authors.initials: PC
authors.lastname: Teixeira
authors.affiliation: Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology.
authors.forename: Isabela Cunha
authors.initials: IC
authors.lastname: Navarro
authors.affiliation: Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Cabantous
authors.affiliation: Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology University of Santo Amaro, São Paulo, Brazil.
authors.forename: Frederico Moraes
authors.initials: FM
authors.lastname: Ferreira
authors.affiliation: Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology.
authors.forename: Darlan
authors.initials: D
authors.lastname: da Silva Cândido
authors.affiliation: Division of Pathology.
authors.forename: Fabio Antônio
authors.initials: FA
authors.lastname: Gaiotto
authors.affiliation: Division of Heart Transplantation, Heart Institute.
authors.forename: Fernando
authors.initials: F
authors.lastname: Bacal
authors.affiliation: Division of Heart Transplantation, Heart Institute.
authors.forename: Pablo
authors.initials: P
authors.lastname: Pomerantzeff
authors.affiliation: Division of Pathology.
authors.forename: Ronaldo Honorato Barros
authors.initials: RH
authors.lastname: Santos
authors.affiliation: Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385, France Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo.
authors.forename: Jorge
authors.initials: J
authors.lastname: Kalil
authors.affiliation: Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology.
authors.forename: Edecio
authors.initials: E
authors.lastname: Cunha-Neto
authors.affiliation: Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Chevillard
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000150:complications* / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D051379:Mice; D009203:Myocardial Infarction / Q000209:etiology* / Q000235:genetics*; D062085:RNA, Long Noncoding; D014157:Transcription Factors
chemical_list: D062085:RNA, Long Noncoding; D014157:Transcription Factors
keywords: Chagas disease; MIAT; biomarker; cardiomyopathy; dilated; lncRNA