title: Surveillance of mosquito-borne infectious diseases in febrile travelers entering China via Shenzhen ports, China, 2013.
abstract: BACKGROUND
  About 100 million passengers enter China via Shenzhen ports every year and such huge populations increase the risk of various infectious diseases, particularly mosquito-borne diseases, entering China. This paper reports the testing and monitoring of mosquito-borne diseases in febrile travelers through Shenzhen ports in 2013.
  
  
  METHODS
  The blood samples of 619 febrile cases were collected and the serum of each sample was used for the specific gene amplification and IgM antibody detection of five typical mosquito-borne pathogens: Dengue virus (DENV), Japanese encephalitis virus (JEV), Chikungunya virus (CHIKV), yellow fever virus (YFV), and West Nile Virus (WNV). Additionally, malaria was diagnosed by rapid diagnostic tests (RDTs).
  
  
  RESULTS
  In total, 34 cases were detected of DENV infection (serotype I to IV), 17 cases of JEV infection, 2 cases of CHIKV infection, and 3 cases of malaria infection. No virus genes or IgM antibodies of YFV or WNV were detected in the samples. DENV, JEV and CHIKV cases were mainly from Southeast Asia, while malaria cases from Africa.
  
  
  CONCLUSIONS
  DENV, JEV and CHIKV were the primary pathogens imported via Shenzhen ports. International travelers with mosquito-borne infections would accelerate the spread of these diseases, thus reinforcing the need for surveillance of mosquito-borne infections at ports should become a high priority.
authors.affiliation: Shen Zhen International Travel Healthcare Center, 8 South of Fuqiang Road, Futian District, Shenzhen, 518033, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Infectious Disease Prevention and Control, Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 155 Changbai Road, Changping District, Beijing, 102206, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, PR China.
authors.forename: Shihong
authors.initials: S
authors.lastname: Fu
authors.affiliation: State Key Laboratory of Infectious Disease Prevention and Control, Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 155 Changbai Road, Changping District, Beijing, 102206, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, PR China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Infectious Disease Prevention and Control, Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 155 Changbai Road, Changping District, Beijing, 102206, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, PR China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Li
authors.affiliation: Shen Zhen International Travel Healthcare Center, 8 South of Fuqiang Road, Futian District, Shenzhen, 518033, PR China.
authors.forename: Dayong
authors.initials: D
authors.lastname: Gu
authors.affiliation: Shen Zhen International Travel Healthcare Center, 8 South of Fuqiang Road, Futian District, Shenzhen, 518033, PR China.
authors.forename: Chunxiao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Shen Zhen International Travel Healthcare Center, 8 South of Fuqiang Road, Futian District, Shenzhen, 518033, PR China.
authors.forename: Chunzhong
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Shen Zhen International Travel Healthcare Center, 8 South of Fuqiang Road, Futian District, Shenzhen, 518033, PR China.
authors.forename: Jian'an
authors.initials: J
authors.lastname: He
authors.affiliation: State Key Laboratory of Infectious Disease Prevention and Control, Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 155 Changbai Road, Changping District, Beijing, 102206, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, PR China. Electronic address: gdliang@hotmail.com.
authors.forename: Guodong
authors.initials: G
authors.lastname: Liang
mesh_terms: D000349:Africa; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D002681:China / Q000453:epidemiology; D009033:Culicidae / Q000469:parasitology / Q000821:virology; D016054:DNA, Protozoan / Q000097:blood; D005334:Fever / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008288:Malaria / Q000175:diagnosis / Q000453:epidemiology; D011159:Population Surveillance; D012327:RNA Virus Infections / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology; D012328:RNA Viruses / Q000302:isolation & purification; D012367:RNA, Viral / Q000097:blood; D014195:Travel
chemical_list: D000913:Antibodies, Protozoan; D000914:Antibodies, Viral; D016054:DNA, Protozoan; D012367:RNA, Viral
keywords: Chikungunya virus; Dengue virus; Febrile travelers; Mosquito-borne diseases