title: Cannabinoid-Elicited Conditioned Place Preference in a Modified Behavioral Paradigm.
abstract: Cannabinoids are the active ingredients in marijuana, which is among the most widely used addictive drugs despite the well-documented harmfulness related to its abuse. The mechanism underlying cannabinoid addiction remains unclear, which is attributed partially to the difficulty in behavioral testing of high-dose cannabinoids using the conditioned place preference (CPP) model. Here, we optimized conditions for establishing CPP with the synthetic cannabinoid HU210 intraperitoneally administered at a high dose. We found that the natural place preference of rats could be exploited for establishing a biased CPP model, and that the adverse effect of HU210 could be ameliorated by adding four daily pre-injections before the conditioning program. Thus, 0.1 mg/kg HU210 induced CPP when pre-injections were administered before traditional conditioning with HU210 administration paired with the non-preferred compartment. The present study provides a useful CPP model for behavioral measurement of the rewarding effects of cannabinoids.
authors.affiliation: Key Laboratory of MOE for Modern Teaching Technology, Shaanxi Normal University.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Qiaohua
authors.initials: Q
authors.lastname: Zheng
authors.forename: Zhaoqiang
authors.initials: Z
authors.lastname: Qian
authors.forename: Haoquan
authors.initials: H
authors.lastname: Wang
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Ren
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Han
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects*; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D020318:Rats, Long-Evans; D017207:Rats, Sprague-Dawley; D012201:Reward
chemical_list: D013759:Dronabinol; C062018:HU 211