title: Crosstalk between the heart and peripheral organs in heart failure.
abstract: Mediators from peripheral tissues can influence the development and progression of heart failure (HF). For example, in obesity, an altered profile of adipokines secreted from adipose tissue increases the incidence of myocardial infarction (MI). Less appreciated is that heart remodeling releases cardiokines, which can strongly impact various peripheral tissues. Inflammation, and, in particular, activation of the nucleotide-binding oligomerization domain-like receptors with pyrin domain (NLRP3) inflammasome are likely to have a central role in cardiac remodeling and mediating crosstalk with other organs. Activation of the NLRP3 inflammasome in response to cardiac injury induces the production and secretion of the inflammatory cytokines interleukin (IL)-1β and IL-18. In addition to having local effects in the myocardium, these pro-inflammatory cytokines are released into circulation and cause remodeling in the spleen, kidney, skeletal muscle and adipose tissue. The collective effects of various cardiokines on peripheral organs depend on the degree and duration of myocardial injury, with systematic inflammation and peripheral tissue damage observed as HF progresses. In this article, we review mechanisms regulating myocardial inflammation in HF and the role of factors secreted by the heart in communication with peripheral tissues.
authors.affiliation: Department of Biology, York University, Toronto, ON, Canada.
authors.forename: James Won Suk
authors.initials: JW
authors.lastname: Jahng
authors.affiliation: Department of Biology, York University, Toronto, ON, Canada.
authors.forename: Erfei
authors.initials: E
authors.lastname: Song
authors.affiliation: Department of Biology, York University, Toronto, ON, Canada.
authors.forename: Gary
authors.initials: G
authors.lastname: Sweeney
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002450:Cell Communication; D016207:Cytokines / Q000378:metabolism; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D007668:Kidney / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D009206:Myocardium / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D013154:Spleen / Q000378:metabolism
chemical_list: D016207:Cytokines; D058847:Inflammasomes