title: Rhodium-Catalyzed Synthesis of 4-Bromo-1,2-dihydroisoquinolines: Access to Bromonium Ylides by the Intramolecular Reaction of a Benzyl Bromide and an α-Imino Carbene.
abstract: Highly functionalized 4-bromo-1,2-dihydroisoquinolines were synthesized from readily available 4-(2-(bromomethyl)phenyl)-1-sulfonyl-1,2,3-triazoles. A bromonium ylide is proposed as the key intermediate, which can be formed by the intramolecular nucleophilic attack of the benzyl bromide on the α-imino rhodium carbene formed in the presence of the rhodium catalyst.
authors.affiliation: Department of Chemistry, Zhejiang Sci-Tech University, Xiasha West Higher Education District, Hangzhou, 310018, China.
authors.forename: Jun
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Chemistry, Zhejiang Sci-Tech University, Xiasha West Higher Education District, Hangzhou, 310018, China.
authors.forename: Yinping
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Chemistry, Zhejiang Sci-Tech University, Xiasha West Higher Education District, Hangzhou, 310018, China.
authors.forename: Wanli
authors.initials: W
authors.lastname: Cheng
authors.affiliation: Department of Chemistry, Zhejiang Sci-Tech University, Xiasha West Higher Education District, Hangzhou, 310018, China.
authors.forename: Zengming
authors.initials: Z
authors.lastname: Man
authors.affiliation: Department of Chemistry, Zhejiang Sci-Tech University, Xiasha West Higher Education District, Hangzhou, 310018, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Chemistry, Zhejiang Sci-Tech University, Xiasha West Higher Education District, Hangzhou, 310018, China. licy@zstu.edu.cn.
authors.forename: Chuan-Ying
authors.initials: CY
authors.lastname: Li
keywords: bromonium ylides; carbenes; isoquinolines; rhodium; triazoles