title: ARHGEF17 sets the timer for retention of Mps1 at kinetochores.
abstract: The kinetochore-associated kinase Mps1 controls the spindle assembly checkpoint, but the regulation of its kinetochore recruitment and activity is unclear. In this issue, Isokane et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201408089) show that interaction with and phosphorylation of its substrate, ARHGEF17, regulates Mps1 kinetochore retention, suggesting an autoregulated, timer-like mechanism.
authors.affiliation: Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Marquardt
authors.affiliation: Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210 fisk.13@osu.edu.
authors.forename: Harold A
authors.initials: HA
authors.lastname: Fisk
mesh_terms: D059447:Cell Cycle Checkpoints / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D006801:Humans; D018386:Kinetochores / Q000378:metabolism* / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D064067:Rho Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D064067:Rho Guanine Nucleotide Exchange Factors; D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases