title: The Interaction of CORM-2 with Block Copolymers Containing Poly(4-vinylpyridine): Macromolecular Scaffolds for Carbon Monoxide Delivery in Biological Systems.
abstract: CORM-2, tricarbonyldichlororuthenium(II) dimer (Ru2 Cl4 (CO)6 ), is a common carbon monoxide releasing molecule (CORM) studied both in vitro and in vivo, but this compound possesses poor water solubility and a short half-life, which hinders its clinical development. Herein, for the first time the conjugation of CORM-2 is reported with a copolymer containing poly(4-vinylpyridine) to yield water-soluble CO-releasing polymeric nanoparticles. CORM-2 is rapidly conjugated to copolymers through pyridine groups as confirmed by inductively coupled plasma-optical emission spectroscopy and infrared spectroscopy. In comparison with free CORM-2, the copolymers functionalized with CORM-2 display better water solubility and the CO release from the polymer-based CORM is slow and sustained. This study paves the way for the potential use of a copolymer encapsulating CORM-2 as a therapeutic agent.
authors.affiliation: Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, University of New South, WalesSydney, NSW, 2052, Australia.
authors.forename: Diep
authors.initials: D
authors.lastname: Nguyen
authors.affiliation: Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, University of New South, WalesSydney, NSW, 2052, Australia.
authors.forename: Nik Nik M
authors.initials: NN
authors.lastname: Adnan
authors.affiliation: Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, University of New South, WalesSydney, NSW, 2052, Australia.|Australian Centre for Nanomedicine (ACN), University of New South Wales, Sydney, NSW, 2052, Australia.
authors.forename: Susan
authors.initials: S
authors.lastname: Oliver
authors.affiliation: Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, University of New South, WalesSydney, NSW, 2052, Australia.|Australian Centre for Nanomedicine (ACN), University of New South Wales, Sydney, NSW, 2052, Australia.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Boyer
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D008823:Micelles; D009211:Myoglobin / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*
chemical_list: D008823:Micelles; D009211:Myoglobin; D009942:Organometallic Compounds; D011145:Polyvinyls; C447082:tricarbonyldichlororuthenium (II) dimer; C019535:poly(4-vinylpyridine); D002248:Carbon Monoxide
keywords: RAFT polymerization; carbon monoxide; drug delivery; macromolecules; nanoparticles