title: Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment.
abstract: We demonstrate in the present study that young host mice rejuvenate aged hair follicles after transplantation. Young mice promote the hair shaft growth of transplanted old hair follicles, as well as young follicles, in contrast to old host mice, which did not support hair-shaft growth from transplanted old or young follicles. Nestin-expressing hair follicle-associated pluripotent (HAP) stem cells of transplanted old and young hair follicles remained active in young host nude mice. In contrast, the nestin-expressing HAP stem cells in young and old hair follicles transplanted to old nude mice were not as active as in young nude host mice. The present study shows that transplanted old hair follicles were rejuvenated by young host mice, suggesting that aging may be reversible.
authors.affiliation: a AntiCancer Inc. , San Diego , CA , USA.|b Department of Surgery , University of California , San Diego , CA , USA.|c Department of Anatomy , Second Military Medical University , Shanghai , China.
authors.forename: Wenluo
authors.initials: W
authors.lastname: Cao
authors.affiliation: a AntiCancer Inc. , San Diego , CA , USA.
authors.forename: Lingna
authors.initials: L
authors.lastname: Li
authors.affiliation: a AntiCancer Inc. , San Diego , CA , USA.|b Department of Surgery , University of California , San Diego , CA , USA.|d Department of Dermatology , Kitasato University , Sagimahara , Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kajiura
authors.affiliation: d Department of Dermatology , Kitasato University , Sagimahara , Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Amoh
authors.affiliation: a AntiCancer Inc. , San Diego , CA , USA.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Tan
authors.affiliation: c Department of Anatomy , Second Military Medical University , Shanghai , China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: a AntiCancer Inc. , San Diego , CA , USA.|b Department of Surgery , University of California , San Diego , CA , USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Hoffman
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D005453:Fluorescence; D049452:Green Fluorescent Proteins / Q000378:metabolism; D018859:Hair Follicle / Q000254:growth & development / Q000637:transplantation*; D008819:Mice, Nude; D008822:Mice, Transgenic; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism; D012060:Rejuvenation; D040521:Subcutaneous Tissue / Q000637:transplantation*; D013997:Time Factors
chemical_list: D049452:Green Fluorescent Proteins
keywords: GFP; aged; growth; hair follicle; hair shaft; mouse; nestin; rejuvenation; stem cell; transplant; young