title: Review of gestational diabetes mellitus effects on vascular structure and function.
abstract: Vascular dysfunction has been described in women with a history of gestational diabetes mellitus. Furthermore, previous gestational diabetes mellitus increases the risk of developing Type 2 diabetes mellitus, a risk factor for cardiovascular disease. Factors contributing to vascular changes remain uncertain. The aim of this review was to summarize vascular structure and function changes found to occur in women with previous gestational diabetes mellitus and to identify factors that contribute to vascular dysfunction. A systematic search of electronic databases yielded 15 publications from 1998 to March 2014 that met the inclusion criteria. Our review confirmed that previous gestational diabetes mellitus contributes to vascular dysfunction, and the most consistent risk factor associated with previous gestational diabetes mellitus and vascular dysfunction was elevated body mass index. Heterogeneity existed across studies in determining the relationship of glycaemic levels and insulin resistance to vascular dysfunction.
authors.affiliation: Edmonton Clinic Health Academy, University of Alberta, Edmonton, AB, Canada lajensen@ualberta.ca.
authors.forename: Louise A
authors.initials: LA
authors.lastname: Jensen
authors.affiliation: Division of Endocrinology & Metabolism, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
authors.forename: Constance L
authors.initials: CL
authors.lastname: Chik
authors.affiliation: Division of Endocrinology & Metabolism, Alberta Diabetes Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
authors.forename: Edmond A
authors.initials: EA
authors.lastname: Ryan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000097:blood / Q000473:pathology / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000097:blood / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D042783:Endothelial Cells / Q000378:metabolism / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000175:diagnosis; D011247:Pregnancy; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin
keywords: Gestational diabetes; diabetes in pregnancy; endothelial dysfunction; vascular function