title: Fragrance allergy could be missed without patch testing with 26 individual fragrance allergens.
abstract: BACKGROUND
  In 2003, the EU Cosmetics Directive stated that 26 fragrance substances must be listed on the cosmetic product ingredient labels. Not all of these 26 fragrance substances are detected by the usual screening markers comprising fragrance mix I, fragrance mix II, and Myroxylon pereirae.
  
  
  OBJECTIVE
  To evaluate the usefulness of testing with the 26 individual fragrance substances in addition to the standard fragrance screening markers.
  
  
  METHODS
  Three hundred and twelve consecutive patients were patch tested with our baseline series and the 26 specific fragrance substances required to be declared on cosmetic product ingredient labels in accordance with the EU Cosmetics Directive.
  
  
  RESULTS
  Positive reactions to at least either one of the 26 individual fragrance substances or the usual fragrance screening markers were seen in 84 of 312 patients (26.9%). Fifteen of these 84 patients (17.8%) reacted negatively to the fragrance screening markers. The most common individual fragrance allergens were cinnamyl alcohol (11.2%), cinnamal (9%), and hydroxycitronellal (3.8%). Sixty-two of 312 patients (19.8%) had at least one positive reaction to the fragrance screening markers.
  
  
  CONCLUSIONS
  Additional patch testing with the 26 individual fragrance allergens, or with the commonest fragrance allergens identified within these 26, should be performed to optimize the detection of fragrance allergy. Cinnamyl alcohol and cinnamal are important fragrance allergens in Thailand.
authors.affiliation: Occupational and Contact Dermatitis Unit, Institute of Dermatology, 420/7 Rajavithi Road, Ratchathewi, Bangkok, 10400, Thailand.
authors.forename: Patnapa
authors.initials: P
authors.lastname: Vejanurug
authors.affiliation: Occupational and Contact Dermatitis Unit, Institute of Dermatology, 420/7 Rajavithi Road, Ratchathewi, Bangkok, 10400, Thailand.
authors.forename: Poohglin
authors.initials: P
authors.lastname: Tresukosol
authors.affiliation: Occupational and Contact Dermatitis Unit, Institute of Dermatology, 420/7 Rajavithi Road, Ratchathewi, Bangkok, 10400, Thailand.
authors.forename: Praneet
authors.initials: P
authors.lastname: Sajjachareonpong
authors.affiliation: Occupational and Contact Dermatitis Unit, Institute of Dermatology, 420/7 Rajavithi Road, Ratchathewi, Bangkok, 10400, Thailand.
authors.forename: Pailin
authors.initials: P
authors.lastname: Puangpet
mesh_terms: D000328:Adult; D000485:Allergens / Q000009:adverse effects* / Q000032:analysis; D015331:Cohort Studies; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D029904:Myroxylon / Q000009:adverse effects; D010328:Patch Tests / Q000379:methods; D010476:Perfume / Q000009:adverse effects* / Q000032:analysis / Q000737:chemistry; D020005:Propanols / Q000009:adverse effects / Q000032:analysis; D011446:Prospective Studies; D017678:Sex Distribution; D013729:Terpenes / Q000009:adverse effects / Q000032:analysis; D013785:Thailand / Q000453:epidemiology
chemical_list: D000485:Allergens; D010476:Perfume; D020005:Propanols; D013729:Terpenes; C020755:hydroxycitronellal; C020722:cinnamyl alcohol
keywords: 26 labelled fragrances; allergic contact dermatitis; fragrances