title: Encapsulation of cannabinoid drugs in nanostructured lipid carriers.
abstract: This study describes the development and optimization of a method to encapsulate the potent and expensive cannabinoids drugs in nanostructured lipid carriers; namely, URB597, AM251 and rimonabant have been considered. NLC production by melt and ultrasonication protocol has been specifically designed to optimize nanoparticle recovery and drug encapsulation efficiency. Special care has been devoted to the modality of oil and water phase emulsification and the entire production has been studied and discussed. NLC recovery, morphology, dimensional distribution and encapsulation efficiency are presented.
authors.affiliation: Department of Life Sciences and Biotechnology, University of Ferrara, I-44121 Ferrara, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Esposito
authors.affiliation: BIMF/Soft Matter Electronmicroscopy, University of Bayreuth, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Drechsler
authors.affiliation: Department of Life Sciences and Biotechnology, University of Ferrara, I-44121 Ferrara, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Cortesi
authors.affiliation: Department of Life Sciences and Biotechnology, University of Ferrara, I-44121 Ferrara, Italy. Electronic address: nas@unife.it.
authors.forename: Claudio
authors.initials: C
authors.lastname: Nastruzzi
mesh_terms: D001549:Benzamides / Q000737:chemistry; D002186:Cannabinoids / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry; D011720:Pyrazoles / Q000737:chemistry; D000077285:Rimonabant
chemical_list: D001549:Benzamides; D002186:Cannabinoids; D002219:Carbamates; D004337:Drug Carriers; D008055:Lipids; D010880:Piperidines; D011720:Pyrazoles; C500528:cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester; C103505:AM 251; D000077285:Rimonabant
keywords: Cannabinoid drugs; Cryo-TEM; Nanostructured lipid carriers