title: Assessment of Depression Prevalence and Its Relation With Interleukin 18 One Year After Renal Transplantation.
abstract: Renal transplantation is the treatment of choice for many patients with end-stage renal disease. Because there is little information about depression after kidney transplantation, we investigated frequency and determinant factors of depression and also its association with interleukin (IL)-18. Kidney transplant recipients were investigated between January 2011 and February 2013. Depression was assessed using the Beck Depression Inventory (BDI, BDI-II). We investigated the relationship between 1-year posttransplantation depression and all-cause mortality, acute kidney injury, and serum creatinine 1, 3, and 12 months after transplantation. Furthermore, the association of depression with IL-18 biomarker was recorded 1 year after transplantation. A total of 74 patients (age: 37.06 ± 16.2 years; 59.5% male) were enrolled in this study 1 year after transplantation. Nineteen (25.6%), 2 (2.7%), and 1 (1.3%) of them experienced mild, moderate, and severe depression, respectively. IL-18 biomarker (independent variable) was significantly associated with depression 1 year after transplantation. Our data suggested that IL-18 level increased significantly in renal transplant patients with depression.
authors.affiliation: 1Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Clinical Pharmacy, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran; 3Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran; and 4Department of Statistics, Faculty of Mathematical Sciences, Shahid Beheshti University, Evin, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Sahraei
authors.forename: Azadeh
authors.initials: A
authors.lastname: Eshraghi
authors.forename: Neda
authors.initials: N
authors.lastname: Eslami
authors.forename: Mona
authors.initials: M
authors.lastname: Mehdizadeh
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology / Q000523:psychology; D000328:Adult; D000367:Age Factors; D015415:Biomarkers; D003404:Creatinine / Q000097:blood; D003863:Depression / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D016030:Kidney Transplantation / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012720:Severity of Illness Index; D012737:Sex Factors; D013997:Time Factors; D066027:Transplant Recipients / Q000523:psychology*
chemical_list: D015415:Biomarkers; D020382:Interleukin-18; D003404:Creatinine