title: Colony Stimulating Factor 3 Mutations and Myeloid Malignancies.
abstract: Granulocyte colony stimulating factor (G-CSF) plays a major role in the proliferation, differentiation, and activation of neutrophil cell line hematopoietic cells. G-CSF exert the function depending on its binding to colony-stimulating factor 3 receptor (CSF3R), a homo-dimer receptor located on the surface of effector cells. Some recent studies have demonstrated that CSF3R mutations play a significant role in many diseases. Some of the hematopoietic diseases, especially myeloid malignancies (e.g. chronic neutrophilic leukemia) are related to the presence of various CSF3R mutations, which leads to abnormal G-CSF signal pathways. Also, the downstream kinases can be the treatment targets for these diseases. This review summarizes CSF3R mutations, mechanisms of mutations, and their contributions to the myeloid malignancies, with an attempt to further reveal the pathogenesis of myeloid malignancies, inform the diagnosis and clinical treatment of the myeloid malignancies, and provide clues for the research and development of new molecular target drugs.
authors.affiliation: Department of Hematology,Tianjin First Central Hospital,the First Central Clinical College of Tianjin Medical University,Tianjin 300192,China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Hematology,Tianjin First Central Hospital,the First Central Clinical College of Tianjin Medical University,Tianjin 300192,China.
authors.forename: Ming-feng
authors.initials: MF
authors.lastname: Zhao
mesh_terms: D003115:Colony-Stimulating Factors; D019337:Hematologic Neoplasms; D006801:Humans; D009154:Mutation; D022423:Myeloid Cells; D016184:Receptors, Colony-Stimulating Factor; D015398:Signal Transduction
chemical_list: C517047:CSF3R protein, human; D003115:Colony-Stimulating Factors; D016184:Receptors, Colony-Stimulating Factor