title: Effects of aerobic dance training on blood pressure in individuals with uncontrolled hypertension on two antihypertensive drugs: a randomized clinical trial.
abstract: There is a dearth of reports on possible additive blood pressure (BP)-reducing effect of aerobic exercise on antihypertensive drug in humans. This study investigated the additive BP-reducing effect of aerobic exercise on BP in individuals with uncontrolled hypertension. In this 12-week double-blind study, 120 new-diagnosed individuals with mild-to-moderate hypertension were randomized to receive coamilozide + 5/10 mg of amlodipine + aerobic dance or coamilozide + 5/10 mg of amlodipine alone. Forty-five and 43 participants in exercise and control groups, respectively, completed the 12-week intervention. Addition of aerobic exercise to antihypertensive drug therapy significantly reduced systolic BP (7.1 mm Hg [95% confidence interval: 5.0, 9.3]; P < .001) and diastolic BP (1.7 mm Hg [95% confidence interval: 0.4, 3.0]; P = .009) at 12 weeks. BP control rate differed significantly between exercise (53.9%) and control (35.3%) groups, P < .001. Postintervention, proportion of participants in exercise group who had their number of antihypertensive drug reduced to one (20.3%) differed from that in control group (11.1%); (χ(2) = 11.0; P = .001). Combination of aerobic dance and antihypertensive drugs reduces number of antihypertensive drugs needed to achieve BP control and enhances BP control in individuals with hypertension on two antihypertensive drugs.
authors.affiliation: Department of Medical Rehabilitation, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria. Electronic address: mafaad@yahoo.com.
authors.forename: Fatai Adesina
authors.initials: FA
authors.lastname: Maruf
authors.affiliation: Department of Physiotherapy, Faculty of Clinical Sciences, University of Ibadan, Ibadan, Oyo State, Nigeria.
authors.forename: Aderonke Omobonike
authors.initials: AO
authors.lastname: Akinpelu
authors.affiliation: Nephrology Unit, Department of Medicine, Faculty of Clinical Sciences, University of Ibadan, Oyo State, Nigeria.
authors.forename: Babatunde Lawal
authors.initials: BL
authors.lastname: Salako
authors.affiliation: Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
authors.forename: Joshua Odunayo
authors.initials: JO
authors.lastname: Akinyemi
mesh_terms: D000328:Adult; D000368:Aged; D000584:Amiloride / Q000008:administration & dosage / Q000627:therapeutic use*; D017311:Amlodipine / Q000008:administration & dosage / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001795:Blood Pressure Determination / Q000295:instrumentation / Q000379:methods; D003131:Combined Modality Therapy; D003614:Dance Therapy; D004311:Double-Blind Method; D004338:Drug Combinations; D015444:Exercise; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D006852:Hydrochlorothiazide; D017311:Amlodipine; C010247:amiloride, hydrochlorothiazide drug combination; D000584:Amiloride
keywords: Aerobic exercise; antihypertensive drug; blood pressure control; hypertension