title: STAT3 inhibitor has potent antitumor activity in B-lineage acute lymphoblastic leukemia cells overexpressing the high mobility group A1 (HMGA1)-STAT3 pathway.
authors.affiliation: a Hematology Division, Department of Medicine , Johns Hopkins University School of Medicine , Baltimore , MD , USA ;
authors.forename: Amy
authors.initials: A
authors.lastname: Belton
authors.affiliation: a Hematology Division, Department of Medicine , Johns Hopkins University School of Medicine , Baltimore , MD , USA ;
authors.forename: Lingling
authors.initials: L
authors.lastname: Xian
authors.affiliation: a Hematology Division, Department of Medicine , Johns Hopkins University School of Medicine , Baltimore , MD , USA ;
authors.forename: Tait
authors.initials: T
authors.lastname: Huso
authors.affiliation: a Hematology Division, Department of Medicine , Johns Hopkins University School of Medicine , Baltimore , MD , USA ;
authors.forename: Michael
authors.initials: M
authors.lastname: Koo
authors.affiliation: a Hematology Division, Department of Medicine , Johns Hopkins University School of Medicine , Baltimore , MD , USA ;
authors.forename: Li Z
authors.initials: LZ
authors.lastname: Luo
authors.affiliation: b Cell and Molecular Biology Department , John A. Burns School of Medicine, University of Hawaii , Honolulu , HI , USA ;
authors.forename: James
authors.initials: J
authors.lastname: Turkson
authors.affiliation: c Department of Chemistry , University of Toronto , Ontario , Canada ;
authors.forename: Brent D G
authors.initials: BD
authors.lastname: Page
authors.affiliation: c Department of Chemistry , University of Toronto , Ontario , Canada ;
authors.forename: Patrick T
authors.initials: PT
authors.lastname: Gunning
authors.affiliation: d Department of Molecular and Comparative Pathobiology , Johns Hopkins University School of Medicine , Baltimore , MD , USA ;
authors.forename: Guosheng
authors.initials: G
authors.lastname: Liu
authors.affiliation: d Department of Molecular and Comparative Pathobiology , Johns Hopkins University School of Medicine , Baltimore , MD , USA ;|e Department of Oncology, Institute for Cellular Engineering , the Johns Hopkins University School of Medicine , Baltimore , MD , USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Huso
authors.affiliation: a Hematology Division, Department of Medicine , Johns Hopkins University School of Medicine , Baltimore , MD , USA ;|e Department of Oncology, Institute for Cellular Engineering , the Johns Hopkins University School of Medicine , Baltimore , MD , USA.
authors.forename: Linda M S
authors.initials: LM
authors.lastname: Resar
mesh_terms: D000636:Aminosalicylic Acids / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D019070:Cell Lineage / Q000187:drug effects / Q000235:genetics; D015973:Gene Expression Regulation, Leukemic / Q000187:drug effects; D025741:HMGA1a Protein / Q000235:genetics / Q000378:metabolism; D006801:Humans; D019169:Jurkat Cells; D051379:Mice; D008819:Mice, Nude; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D054448:Precursor Cells, B-Lymphoid / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D050796:STAT3 Transcription Factor / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D013449:Sulfonamides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D015854:Up-Regulation / Q000187:drug effects / Q000235:genetics; D023041:Xenograft Model Antitumor Assays
chemical_list: D000636:Aminosalicylic Acids; D000970:Antineoplastic Agents; C000595192:BP-1-102; D050796:STAT3 Transcription Factor; D013449:Sulfonamides; D025741:HMGA1a Protein