title: Three new triterpenoid saponins from the roots of Ardisia crenata and their cytotoxic activities.
abstract: Three new triterpenoid saponins, ardisicrenoside O (1), ardisicrenoside P (2) and ardisicrenoside Q (3) together with three known compounds, 3β,16α-dihydroxy-30-methoxy-28, 30-epoxy-olean-12-en, cyclamiretin A 3-O-β-d-glucopyranosyl-(1→2) -α-l-arabinopyranoside and cyclamiretin A 3-O-β-d-glucopyranosyl-(1→4) -α-l-arabinopyranoside were isolated from the roots of Ardisia crenata Sims. Their structures were determined by one- and two-dimensional NMR techniques, including HSQC, HMBC and TOCSY experiments, as well as acid hydrolysis and GC analysis. All isolates were evaluated for the cytotoxic activities on two human cancer cell lines and compounds 3, 5 and 6 showed significant cytotoxicity.
authors.affiliation: a Tianjin Key Laboratory for Prevention and Control of Occupational and Environmental hazard , Tianjin , P.R. China.|b Department of Pharmacognosy , Logistics University of Chinese People's Armed Police Forces , Tianjin , P.R. China.
authors.forename: Dai-Lin
authors.initials: DL
authors.lastname: Liu
authors.affiliation: c Department of Natural Products Chemistry , Shenyang Pharmaceutical University , Shenyang , P.R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.affiliation: a Tianjin Key Laboratory for Prevention and Control of Occupational and Environmental hazard , Tianjin , P.R. China.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: c Department of Natural Products Chemistry , Shenyang Pharmaceutical University , Shenyang , P.R. China.
authors.forename: Nai-Li
authors.initials: NL
authors.lastname: Wang
authors.affiliation: c Department of Natural Products Chemistry , Shenyang Pharmaceutical University , Shenyang , P.R. China.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
keywords:  Sims; cytotoxicity; oleanane; triterpenoid saponins