title: Neonatal adiposity increases with rising cord blood IGF-1 levels.
abstract: Infants with higher adiposity at birth may be at greater risk of developing obesity later in life. IGF-1 is important for intrauterine growth and may be a useful early life marker of adiposity, and thus later obesity risk. The aim of this study was to determine the relationship between cord blood IGF-1, neonatal anthropometrics and markers of neonatal adiposity.
  
  
  
  A cross-sectional study design was utilized to study a multiethnic cohort of full-term neonates born to healthy mothers with normal glucose tolerance at a large university hospital. Neonatal cord blood was collected after birth and assayed for IGF-1, leptin and C-peptide. Neonatal body composition was measured between 24 and 72 h of life using the method of air displacement plethysmography.
  
  
  
  Cord blood IGF-1 was positively and significantly associated with markers of neonatal adiposity in models adjusted for maternal age at delivery, race, maternal prepregnancy BMI, gestational age at delivery and neonatal sex: birthweight (r = 0·62, P < 0·001), leptin (r = 0·33, P = 0·018), fat mass (r = 0·52, P < 0·001) and percent body fat (r = 0·51, P < 0·001). Cord blood IGF-1 was not associated with cord blood C-peptide.
  
  
  
  Cord blood IGF-1 is strongly associated with all measures of neonatal adiposity suggesting that IGF-1 may be an important contributor to in utero neonatal fat accumulation.
authors.affiliation: Division of Endocrinology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Kadakia
authors.affiliation: Biostatistics Collaboration Center, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Ma
authors.affiliation: Division of Endocrinology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Jami L
authors.initials: JL
authors.lastname: Josefson
mesh_terms: D050154:Adiposity; D000328:Adult; D001823:Body Composition; D002096:C-Peptide / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000502:physiology*; D020738:Leptin / Q000097:blood; D008297:Male; D008423:Maternal Age; D011247:Pregnancy
chemical_list: D002096:C-Peptide; D020738:Leptin; D007334:Insulin-Like Growth Factor I