title: Centroacinar cells: At the center of pancreas regeneration.
abstract: The process of regeneration serves to heal injury by replacing missing cells. Understanding regeneration can help us replace cell populations lost during disease, such as the insulin-producing β cells lost in diabetic patients. Centroacinar cells (CACs) are a specialized ductal pancreatic cell type that act as progenitors to replace β cells in the zebrafish. However, whether CACs contribute to β-cell regeneration in adult mammals remains controversial. Here we review the current understanding of the role of CACs as endocrine progenitors during regeneration in zebrafish and mammals.
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, United States. Electronic address: rbeer2@jhmi.edu.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Beer
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, United States; Department of Surgery, Johns Hopkins University, Baltimore, MD, United States.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Parsons
authors.affiliation: Genomic Programming of Beta-Cells Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain. Electronic address: merovira@clinic.ub.es.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Rovira
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D055098:Endocrine Cells / Q000166:cytology; D006706:Homeostasis; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000378:metabolism; D008322:Mammals; D051379:Mice; D010179:Pancreas / Q000166:cytology / Q000196:embryology* / Q000502:physiology*; D010183:Pancreatic Ducts / Q000166:cytology*; D012038:Regeneration; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology; D015027:Zebrafish
keywords: Centroacinar cell; Pancreas; Progenitor; Regeneration; Zebrafish; β cell