title: Biological role and clinical implications of homeobox genes in serous epithelial ovarian cancer.
abstract: Homeobox (HOX) genes are a family of transcription factors that are essential regulators of development. HOX genes play important roles in normal reproductive physiology, as well as in the development and progression of serous carcinomas, the predominant and most aggressive subtype of epithelial ovarian cancer (EOC). This review discusses aberrant HOX gene expression in serous EOC and its impact on tumor development and progression. Further identification of HOX target genes may facilitate the development of novel diagnostic and therapeutic strategies to improve the prognosis of patients with serous EOC.
authors.affiliation: Department of Cancer Pharmacology, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA.
authors.forename: Katherine R
authors.initials: KR
authors.lastname: Miller
authors.affiliation: Department of Cancer Pharmacology, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA.
authors.forename: Jai N
authors.initials: JN
authors.lastname: Patel
authors.affiliation: Department of Cancer Pharmacology, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA.
authors.forename: Mahrukh K
authors.initials: MK
authors.lastname: Ganapathi
authors.affiliation: Division of Gynecologic Oncology, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA. Electronic address: david.tait@carolinashealthcare.org.
authors.forename: David L
authors.initials: DL
authors.lastname: Tait
authors.affiliation: Department of Cancer Pharmacology, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA. Electronic address: ram.ganapathi@carolinashealthcare.org.
authors.forename: Ram N
authors.initials: RN
authors.lastname: Ganapathi
mesh_terms: D000818:Animals; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005801:Genes, Homeobox; D006801:Humans; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology
keywords: Cancer; Gene; HOX; Ovarian; Protein; Serous