title: Norsesquiterpenoids and triterpenoids from strawberry cv. Falandi.
abstract: Falandi is a common strawberry (Fragaria × ananassa Duch.) cultivar in southern China. Further study of the chemical constituents in Falandi fruit led to the isolation of nine norsesquiterpenoids and three triterpenoids. Falandioside D (1) and falandins A (2) and B (3) were new norsesquiterpenoids, and the others excluding tormentic acid (11) were found in strawberry for the first time. Compounds 1 and 11 exhibited potent α-glucosidase inhibitory activity with the half maximal inhibitory concentration (IC50) values of 565.0 and 27.4 μM in comparison to acarbose (619.9 μM). Compounds 3, 7 (blumenol C glucoside), and 11 showed cytotoxicity against human nasopharyngeal carcinoma cell line CNE1 with the IC50 values of 57.6, 56.4, and 36.0 μM, respectively. Among new compounds, 1 showed 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical cation scavenging capacity (IC50=36.2 μM). These results suggested that non-phenolic constituents were also involved in the antidiabetic, antitumour, and antioxidant effects of strawberry fruit.
authors.affiliation: Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, China; Foundation College, Jining Medical University, Jining 272067, Shangdong, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.affiliation: Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liang
authors.affiliation: Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, China. Electronic address: xiehaih@scbg.ac.cn.
authors.forename: Haihui
authors.initials: H
authors.lastname: Xie
authors.affiliation: Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis / Q000494:pharmacology; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002681:China; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D031985:Fragaria / Q000737:chemistry* / Q000254:growth & development; D005638:Fruit / Q000737:chemistry*; D005960:Glucosides / Q000032:analysis / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors / Q000032:analysis / Q000494:pharmacology; D006801:Humans; D045792:Norisoprenoids / Q000032:analysis / Q000494:pharmacology; D012717:Sesquiterpenes / Q000032:analysis* / Q000494:pharmacology; D014315:Triterpenes / Q000032:analysis* / Q000494:pharmacology; D000520:alpha-Glucosidases / Q000032:analysis
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D005960:Glucosides; D065089:Glycoside Hydrolase Inhibitors; D045792:Norisoprenoids; D012717:Sesquiterpenes; D014315:Triterpenes; C007695:euscaphic acid; C549752:9-hydroxymegastigman-4-en-3-one 9-O-beta-D-glucopyranoside; D000520:alpha-Glucosidases
keywords: (6S,9R)-Roseoside (PubChem CID: 9930064); 4,6E-Megastigmadien-3-one-9-glucoside (PubChem CID: 76335966); 4,6Z-Megastigmadien-3-one-9-glucoside (PubChem CID: 76310564); Blumenol C glucoside (PubChem CID: 14135395); Corchoionoside C (PubChem CID: 10317980); Cytotoxicity; Norsesquiterpenoids; Sericic acid (PubChem CID: 124214); Strawberry; Tormentic acid (PubChem CID: 73193); Triterpenoids; α-Glucosidase inhibitory activity