title: Evaluation of Soft Tissue Reaction to Corundum Ceramic Implants Infiltrated with Colloidal Silver.
abstract: BACKGROUND
  Corundum ceramic is a biomaterial used as a bone graft substitute. Silver is a well known antiseptic substance with many practical, clinical applications.
  
  
  OBJECTIVE
  The aim of this study was to estimate soft tissue (in vivo) reaction to a new kind of ceramic implants. In our experiment, we examined the soft tissue reaction after implantation of corundum ceramic infiltrated with colloidal silver in the back muscles of 18 Wistar rats. The use of colloidal silver as a coating for the implant was designed to protect it against colonization by bacteria and the formation of bacterial biofilm.
  
  
  METHODS
  In our study, based on the experimental method, we performed implantation operations on 18 Wistar rats. We implanted 18 modified ceramic implants and, as a control group, 18 unmodified implants. As a follow up, we observed the animals operated upon, and did postoperative, autopsy and histopathological examinations 14, 30, 90 and 180 days after implantation.
  
  
  RESULTS
  We didn't observe any pathological reactions and significant differences between the soft tissue reaction to the modified implants and the control group.
  
  
  CONCLUSIONS
  Lack of pathological reaction to the modified implants in the living organism is the proof of their biocompatibility. This is, of course, the first step on the long path to introduce a new kind of biocompatible ceramic implant with antiseptic cottage. Our experiment has an only introductory character and we plan to perform other, more specific, tests of this new kind of implant.
authors.affiliation: Department of Traumatology, Clinic of Traumatology and Hand Surgery, Wroclaw Medical University, Poland.
authors.forename: Witold
authors.initials: W
authors.lastname: Wnukiewicz
authors.affiliation: Department of Sport Medicine, The University School of Physical Education, Wrocław, Poland.
authors.forename: Roman
authors.initials: R
authors.lastname: Rutowski
authors.affiliation: Department of Ceramics and Bioplastics, Institute of Electrical Engineering, Wrocław, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Zboromirska-Wnukiewicz
authors.affiliation: Department of Traumatology, Clinic of Traumatology and Hand Surgery, Wroclaw Medical University, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Reichert
authors.affiliation: Department of Traumatology, Clinic of Traumatology and Hand Surgery, Wroclaw Medical University, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Gosk
mesh_terms: D000537:Aluminum Oxide / Q000633:toxicity; D000818:Animals; D064131:Back Muscles / Q000187:drug effects* / Q000473:pathology / Q000601:surgery*; D018786:Bone Substitutes / Q000009:adverse effects; D002516:Ceramics / Q000633:toxicity; D020099:Coated Materials, Biocompatible; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D023421:Models, Animal; D017208:Rats, Wistar; D012834:Silver / Q000008:administration & dosage* / Q000633:toxicity; D013997:Time Factors
chemical_list: D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; C586932:colloidal silver; D012834:Silver; D000537:Aluminum Oxide