title: Impact of the bioresorbable vascular scaffold surface area on on-treatment platelet reactivity.
abstract: While promising data with the novel bioresorbable vascular scaffold (BVS) are accumulating, signals of scaffold thrombosis (ST) were noted in recent reports. We aimed to assess the relationship between the total surface area (TSA) of implanted everolimus-eluting BVSs and the on-treatment adenosine diphosphate (ADP)-induced platelet reactivity in patients undergoing percutaneous coronary intervention (PCI). 202 consecutive patients undergoing BVS implantation and platelet function testing were included. For investigating the impact of the scaffold surface on platelet reactivity, patients were stratified into two groups regarding the median BVS TSA. The on-treatment ADP-induced platelet reactivity was determined with the Multiplate analyzer and 30-day follow-up was available in 98% of patients. ADP-induced platelet aggregation values (median, [IQR]) did not differ between the two study groups (12.0 [9.0-19.0] U for patients with TSA > 1.39 cm(2) and 13.0 [9.0-19.5] U for patients with TSA ≤ 1.39 cm(2); p = 0.69). No correlation was observed between the BVS TSA and levels of platelet reactivity (Spearman rank correlation = -0.10, p = 0.16). At 30 days after PCI, two early STs (1%) were documented. Thus, in patients on a dual antiplatelet treatment regimen following BVS implantation, the extent of blood-to-BVS contact surface does not negatively affect levels of on-treatment platelet reactivity.
authors.affiliation: a Department of Cardiology , Munich University Hospital, Ludwig-Maximilians-University , Munich , Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Gross
authors.affiliation: a Department of Cardiology , Munich University Hospital, Ludwig-Maximilians-University , Munich , Germany.|b DZHK (German Center for Cardiovascular Research) , partner site Munich Heart Alliance , Munich , Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Sibbing
authors.affiliation: a Department of Cardiology , Munich University Hospital, Ludwig-Maximilians-University , Munich , Germany.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Eickhoff
authors.affiliation: a Department of Cardiology , Munich University Hospital, Ludwig-Maximilians-University , Munich , Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Baquet
authors.affiliation: a Department of Cardiology , Munich University Hospital, Ludwig-Maximilians-University , Munich , Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Orban
authors.affiliation: a Department of Cardiology , Munich University Hospital, Ludwig-Maximilians-University , Munich , Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Krieg
authors.affiliation: a Department of Cardiology , Munich University Hospital, Ludwig-Maximilians-University , Munich , Germany.
authors.forename: Katarina
authors.initials: K
authors.lastname: Grujic
authors.affiliation: a Department of Cardiology , Munich University Hospital, Ludwig-Maximilians-University , Munich , Germany.
authors.forename: Hans D
authors.initials: HD
authors.lastname: Theiss
authors.affiliation: a Department of Cardiology , Munich University Hospital, Ludwig-Maximilians-University , Munich , Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Brunner
authors.affiliation: c Department of Laboratory Medicine , Ludwig-Maximilians-University , Munich , Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Teupser
authors.affiliation: c Department of Laboratory Medicine , Ludwig-Maximilians-University , Munich , Germany.
authors.forename: Lesca
authors.initials: L
authors.lastname: Holdt
authors.affiliation: a Department of Cardiology , Munich University Hospital, Ludwig-Maximilians-University , Munich , Germany.|b DZHK (German Center for Cardiovascular Research) , partner site Munich Heart Alliance , Munich , Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Massberg
authors.affiliation: a Department of Cardiology , Munich University Hospital, Ludwig-Maximilians-University , Munich , Germany.|b DZHK (German Center for Cardiovascular Research) , partner site Munich Heart Alliance , Munich , Germany.
authors.forename: Julinda
authors.initials: J
authors.lastname: Mehilli
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D015539:Platelet Activation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D012189:Retrospective Studies; D013927:Thrombosis / Q000097:blood / Q000209:etiology / Q000628:therapy; D054457:Tissue Scaffolds; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors
keywords: Bioresorbable vascular scaffold; platelet activation; platelet function testing; scaffold thrombosis