title: Febuxostat for the chronic management of hyperuricemia in patients with gout.
abstract: Febuxostat is a non-purine, selective inhibitor of both isoforms of xanthine oxido-reductase (XOR), and a major alternative to the scarce number of urate-lowering medications available in the last decades. Its inhibition of XOR is more potent than allopurinol in a mg to mg comparison, what is associated to achievement of serum urate target more frequently than allopurinol at doses tested in clinical trials, especially in patients with the highest baseline serum urate levels. Its pharmacokinetics is not greatly dependent on renal clearance, contrary to allopurinol, what may be an advantage in patients with chronic kidney disease. Several trials are further evaluating both the cardiovascular safety of febuxostat and its possible beneficial effect on renal function preservation. Still scarce, but clinically interesting, evidence on its use in transplant patients has been recently released.
authors.affiliation: a Rheumatology Division , Hospital Universitario Cruces, OSI EE-Cruces , Baracaldo , Spain.
authors.forename: Sandra Pamela
authors.initials: SP
authors.lastname: Chinchilla
authors.affiliation: a Rheumatology Division , Hospital Universitario Cruces, OSI EE-Cruces , Baracaldo , Spain.
authors.forename: Irati
authors.initials: I
authors.lastname: Urionaguena
authors.affiliation: a Rheumatology Division , Hospital Universitario Cruces, OSI EE-Cruces , Baracaldo , Spain.|b Biocruces Health Research Institute , Baracaldo , Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Perez-Ruiz
mesh_terms: D004334:Drug Administration Schedule; D000069465:Febuxostat / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006073:Gout / Q000188:drug therapy*; D006074:Gout Suppressants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy*
chemical_list: D006074:Gout Suppressants; D000069465:Febuxostat
keywords: Gout; allopurinol; cardiovascular disease; chronic kidney disease; febuxostat; hyperuricemia