title: Mild Cognitive Impairment and Dementia Prevalence: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).
abstract: BACKGROUND
  We examined prevalence of mild cognitive impairment (MCI) and dementia in the Atherosclerosis Risk in Communities (ARIC) Neurocognitive Study.
  
  
  METHODS
  Beginning in June, 2011, we invited all surviving ARIC participants to undergo cognitive, neurological and brain imaging assessments to diagnose MCI or dementia and assign an etiology for the cognitive disorder.
  
  
  RESULTS
  Of 10713 surviving ARIC participants (age range 69-88 yrs), we ascertained cognitive diagnoses in 6471 in-person, 1966 by telephone interviews (participant or informant) and the remainder by medical record review. The prevalence of dementia was 9.0% and MCI 21%. Alzheimer's disease was the primary or secondary etiology in 76% of dementia and 75% of MCI participants. Cerebrovascular disease was the primary or secondary etiology in 46% of dementia and 32% of MCI participants.
  
  
  CONCLUSIONS
  MCI and dementia were common among survivors from the original ARIC cohort. Nearly 30% of the ARIC cohort received diagnoses of either dementia or MCI, and for the majority of these individuals (about 75%) the etiologic basis was attributed to Alzheimer's disease.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN.
authors.forename: David S
authors.initials: DS
authors.lastname: Knopman
authors.affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: Rebecca F
authors.initials: RF
authors.lastname: Gottesman
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
authors.forename: A Richey
authors.initials: AR
authors.lastname: Sharrett
authors.affiliation: Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Wruck
authors.affiliation: Department of Medicine; University of Mississippi Medical Center, Jackson, MS.
authors.forename: B Gwen
authors.initials: BG
authors.lastname: Windham
authors.affiliation: Division of Public Health Sciences, School of Medicine, Wake Forest University, Winston-Salem, NC.
authors.forename: Laura
authors.initials: L
authors.lastname: Coker
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
authors.forename: Andrea Lc
authors.initials: AL
authors.lastname: Schneider
authors.affiliation: Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
authors.forename: Sun
authors.initials: S
authors.lastname: Hengrui
authors.affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Alonso
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
authors.forename: Josef
authors.initials: J
authors.lastname: Coresh
authors.affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: Marilyn S
authors.initials: MS
authors.lastname: Albert
authors.affiliation: Department of Medicine; University of Mississippi Medical Center, Jackson, MS.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Mosley
keywords: Alzheimer’s disease; cerebrovascular disease; dementia; epidemiology; mild cognitive impairment; prevalence