title: Factors affecting the quality of life in drug-resistant epilepsy patients.
abstract: Epilepsy patients whose seizures cannot be controlled by treatment have a lower quality of life (QoL). The aim of the present study was to compare the potential factors affecting the QoL in patients who were seizure-free with medication or who had drug-resistant epilepsy. The study included 46 drug-resistant and 42 seizure-free epilepsy patients. The demographic and clinical features of the patients were investigated for their effects on patient QoL. The QoL was assessed by the QoL in Epilepsy Inventory-89 and depression was detected by the Beck Depression Inventory. The QoL was significantly lower in the drug-resistant patients than in the seizure-free epilepsy patients (p < 0.001). Depression, lower education level, and unemployment were associated with lower QoL scores (p < 0.001, p < 0.01, p < 0.001, respectively). After adjusting for lower education level and unemployment, depression remained as an independent factor affecting QoL (p < 0.05). In addition to their efforts to control and stop seizures, clinicians should remain aware of depression and treat it effectively to improve the QoL of drug-resistant epilepsy patients.
authors.affiliation: Department of Neurology, Trakya University Medical Faculty, 22030, Edirne, Turkey.
authors.forename: Vedat
authors.initials: V
authors.lastname: Akdemir
authors.affiliation: Department of Biostatistics, Trakya University Medical Faculty, Edirne, Turkey.
authors.forename: Necdet
authors.initials: N
authors.lastname: Sut
authors.affiliation: Department of Neurology, Trakya University Medical Faculty, 22030, Edirne, Turkey. baburhan@hotmail.com.
authors.forename: Baburhan
authors.initials: B
authors.lastname: Guldiken
mesh_terms: D000328:Adult; D003863:Depression / Q000453:epidemiology / Q000209:etiology; D000069279:Drug Resistant Epilepsy / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life
keywords: Depression; Drug resistance; Epilepsy; Quality of life