title: Positive TTF-1 Expression in Malignant Mesothelioma: A Case Report.
abstract: BACKGROUND
  The histopathological diagnosis of malignant mesothelioma is based mainly on the immunohistological profile of the neoplasia, using different immunohistochemical markers to distinguish between a malignant mesothelioma and a carcinoma.
  
  
  METHODS
  A female patient presented with a right paravertebral rapidly growing tumor and severe pain. Based on the immunohistochemical findings, we present the first case of a malignant mesothelioma with immunohistochemical expression of thyroid transcription factor-1.
  
  
  CONCLUSIONS
  The detection of a positive reaction for thyroid transcription factor-1 in the tumor cells may not exclude a malignant mesothelioma.
authors.affiliation: , Institute of Pathology, Hameln, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Richter
authors.affiliation: Department of Radiology, Sana Klinikum Hameln-Pyrmont, Hameln, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Heidersdorf
authors.affiliation: Department of Radiation Therapy & Radiation Oncology, Hannover-Hildesheim-Hameln, Hamelin, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Hirschfeld
authors.affiliation: Department of Oncology, Sana Klinikum Hameln-Pyrmont, Hamelin, Germany.
authors.forename: Friedhelm
authors.initials: F
authors.lastname: Krebbel
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D008654:Mesothelioma / Q000175:diagnosis / Q000378:metabolism*; D000086002:Mesothelioma, Malignant; D009687:Nuclear Proteins / Q000378:metabolism*; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors