title: [Progress on the Function of Herpesvirus-encoded MicroRNAs].
abstract: Since Epstein Barr virus was shown to encode microRNAs(miRNAs) in 2004, more than 470 miRNAs have been discovered in α-, β-, and γ-herpesviruses. MiRNAs are small non-coding RNA molecules and generally only have 18-25 nucleotides in length, which can regulate the expression of target genes by targeting its transcripts. Herpesvirus-encoded miRNAs not only target the key genes from latency to lytic replication, but also regulate various host cellular genes. Current data manifest that herpesvirus-encoded miRNAs can regulate viral latent infection and lytic replication, immune recognition, apoptosis, and tumorigenesis. The purpose of this paper is to summarize the targets and their fuction of hepesvirus-encoded miRNAs, in order to provide theoretical support for further analysis herpesviral pathogenesis.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Cai
authors.forename: Renyong
authors.initials: R
authors.lastname: Jia
mesh_terms: D000818:Animals; D006564:Herpesviridae / Q000235:genetics / Q000378:metabolism*; D006566:Herpesviridae Infections / Q000821:virology*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D012367:RNA, Viral