title: Clinical Trials in Retinal Dystrophies.
abstract: Research development is burgeoning for genetic and cellular therapy for retinal dystrophies. These dystrophies are the focus of many research efforts due to the unique biology and accessibility of the eye, the transformative advances in ocular imaging technology that allows for in vivo monitoring, and the potential benefit people would gain from success in the field - the gift of renewed sight. Progress in the field has revealed the immense complexity of retinal dystrophies and the challenges faced by researchers in the development of this technology. This study reviews the current trials and advancements in genetic and cellular therapy in the treatment of retinal dystrophies and also discusses the current and potential future challenges.
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
authors.forename: Seanna R
authors.initials: SR
authors.lastname: Grob
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
authors.forename: Avni
authors.initials: A
authors.lastname: Finn
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA; Retina, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
authors.forename: Thanos D
authors.initials: TD
authors.lastname: Papakostas
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA; Retina, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
authors.forename: Dean
authors.initials: D
authors.lastname: Eliott
mesh_terms: D064987:Cell- and Tissue-Based Therapy; D002986:Clinical Trials as Topic; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D058499:Retinal Dystrophies / Q000628:therapy*
keywords: Cell Therapy; Genetic Therapy; Retinal Dystrophies