title: Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy.
abstract: Trauma-induced coagulopathy (TIC) is a recently described condition which traditionally has been diagnosed by the common coagulation tests (CCTs) such as prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen levels. The varying sensitivity and specificity of these CCTs have led trauma coagulation researchers and clinicians to use Viscoelastic Tests (VET) such as Thromboelastography (TEG) to provide Targeted Thromboelastographic Hemostatic and Adjunctive Therapy (TTHAT) in a goal directed fashion to those trauma patients in need of hemostatic resuscitation. This review describes the utility of VETs, in particular, TEG, to provide TTHAT in trauma and acquired non-trauma-induced coagulopathy.
authors.affiliation: Memorial Hospital of South Bend, South Bend, Indiana 46601, USA. markwalshmd@gmail.com.
authors.forename: Mark
authors.initials: M
authors.lastname: Walsh
authors.forename: Stephanie
authors.initials: S
authors.lastname: Fritz
authors.forename: Daniel
authors.initials: D
authors.lastname: Hake
authors.forename: Michael
authors.initials: M
authors.lastname: Son
authors.forename: Sarah
authors.initials: S
authors.lastname: Greve
authors.forename: Manar
authors.initials: M
authors.lastname: Jbara
authors.forename: Swetha
authors.initials: S
authors.lastname: Chitta
authors.forename: Braxton
authors.initials: B
authors.lastname: Fritz
authors.forename: Adam
authors.initials: A
authors.lastname: Miller
authors.forename: Mary K
authors.initials: MK
authors.lastname: Bader
authors.forename: Jonathon
authors.initials: J
authors.lastname: McCollester
authors.forename: Sophia
authors.initials: S
authors.lastname: Binz
authors.forename: Alyson
authors.initials: A
authors.lastname: Liew-Spilger
authors.forename: Scott
authors.initials: S
authors.lastname: Thomas
authors.forename: Anton
authors.initials: A
authors.lastname: Crepinsek
authors.forename: Faisal
authors.initials: F
authors.lastname: Shariff
authors.forename: Victoria
authors.initials: V
authors.lastname: Ploplis
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Castellino
mesh_terms: D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006489:Hemostatic Techniques; D006801:Humans; D010314:Partial Thromboplastin Time / Q000379:methods; D010976:Platelet Count; D011517:Prothrombin Time / Q000379:methods; D012680:Sensitivity and Specificity; D013916:Thrombelastography / Q000379:methods*; D014947:Wounds and Injuries / Q000150:complications*