title: Impact of Serum Uric Acid Levels on Coronary Plaque Stability Evaluated Using Integrated Backscatter Intravascular Ultrasound in Patients with Coronary Artery Disease.
abstract: OBJECTIVE
  Because the prevalence of hyperuricemia is lower in females than in males, the association between hyperuricemia and cardiovascular disease has been frequently reported in females. Increased serum uric acid levels are associated with the presence of cardiovascular risk factors such as hypertension, renal dysfunction, insulin resistance, and metabolic syndrome. However, it is controversial whether hyperuricemia is an independent risk factor for coronary artery disease in both the genders. The purpose of this study was to investigate the relationship between serum uric acid levels and coronary plaque components assessed using integrated backscatter intravascular ultrasound (IB-IVUS) in males and females.
  
  
  METHODS
  In total, 385 patients (298 males and 87 females) who underwent percutaneous coronary intervention using IB-IVUS were divided into three groups in each gender according to their serum uric acid levels. We characterized tissue from coronary plaques in culprit lesions.
  
  
  RESULTS
  Serum uric acid levels significantly correlated with percent lipid volume (r=0.37) and inversely correlated with percent fibrous volume (r=－0.35). Multivariate analysis showed that the uric acid level was independently associated with lipid-rich plaques (odds ratio 2.43, 95%, confidence interval 1.75-3.47). The prevalence of lipid-rich plaques increased with increasing uric acid levels in both genders.
  
  
  CONCLUSIONS
  Increased serum uric acid levels were associated with larger lipid content plaques in both genders.
authors.affiliation: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Ando
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Tetsu
authors.initials: T
authors.lastname: Watanabe
authors.forename: Hyuma
authors.initials: H
authors.lastname: Daidoji
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Otaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishiyama
authors.forename: Takanori
authors.initials: T
authors.lastname: Arimoto
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Shishido
authors.forename: Takehiko
authors.initials: T
authors.lastname: Miyashita
authors.forename: Takuya
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007564:Japan / Q000453:epidemiology; D008297:Male; D058226:Plaque, Atherosclerotic / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology*; D015995:Prevalence; D018084:Ultrasonography, Interventional / Q000379:methods*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid