title: Acute angle-closure glaucoma in a highly myopic patient secondary to Weill-Marchesani syndrome: histopathologic lens features.
abstract: The authors describe a case of acute angle-closure glaucoma in a highly myopic patient secondary to Weill-Marchesani syndrome (WMS) and histopathologic features of his lens. A 37-year-old male patient visited our clinic for ocular pain with elevated intraocular pressure (19/57 mmHg). The slit-lamp examination showed an inferiorly subluxated lens in the right eye, and anterior dislocated microspherophakia with corneolenticular contact in the left eye. The physical examination showed brachydactyly and relatively short stature. To control the IOP and to improve visual acuity, lens extraction, anterior vitrectomy, and scleral-sutured IOL implantation surgery were performed. To the best of our knowledge, this is the first histopathologic report of bilateral lens in a Korean patient with WMS. The pathologic specimens showed epithelial cell changes, hyaloid degeneration, and subcapsular cortical fiber changes. The authors attributed these changes to physical and mechanical factors because the lens is highly mobile and often comes in contact with the iris.
authors.affiliation: Department of Ophthalmology, Yeungnam University College of Medicine, #170 Hyeonchung-ro, Nam-gu, Daegu, 705-717, Republic of Korea.|Department of Ophthalmology, Daegu Veterans Health Service Center, Daegu, Republic of Korea.
authors.forename: Su-Ho
authors.initials: SH
authors.lastname: Lim
authors.affiliation: Department of Ophthalmology, Yeungnam University College of Medicine, #170 Hyeonchung-ro, Nam-gu, Daegu, 705-717, Republic of Korea.
authors.forename: Jun Hyuk
authors.initials: JH
authors.lastname: Son
authors.affiliation: Department of Ophthalmology, Yeungnam University College of Medicine, #170 Hyeonchung-ro, Nam-gu, Daegu, 705-717, Republic of Korea. sccha@yumail.ac.kr.
authors.forename: Soon Cheol
authors.identifier: http://orcid.org/0000-0002-9887-2354
authors.initials: SC
authors.lastname: Cha
mesh_terms: D000328:Adult; D003316:Corneal Diseases / Q000150:complications; D004479:Ectopia Lentis / Q000150:complications; D005901:Glaucoma / Q000150:complications; D015812:Glaucoma, Angle-Closure / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007498:Iris / Q000002:abnormalities; D007908:Lens, Crystalline / Q000473:pathology*; D008297:Male; D009216:Myopia / Q000473:pathology*; D056846:Weill-Marchesani Syndrome / Q000150:complications*
keywords: Angle-closure glaucoma; Microspherophakia; Pathology; Weill–Marchesani syndrome