title: Polymorphisms of the PPAR-γ (rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus.
abstract: Background. The present study was designed to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (PGC-1α) gene (rs8192673) are associated with markers of carotid and coronary atherosclerosis in Caucasians with type 2 diabetes mellitus (T2DM). Patients and Methods. 595 T2DM subjects and 200 control subjects were enrolled in the cross-sectional study. Markers of carotid atherosclerosis were assessed ultrasonographically. In 215 out of 595 subjects with T2DM, a coronary computed tomography angiography (CCTA) was performed for diagnostic purposes. Genotyping of either rs1801282 or rs8192673 was performed using KASPar assays. Results. In our study, we demonstrated an effect of the rs1801282 on markers of carotid atherosclerosis (presence of plaques) in Caucasians with T2DM in univariate and in multivariable linear regression analyses. Finally, we did not demonstrate any association between either rs1801282 or rs8192673 and markers of coronary atherosclerosis. Conclusions. In our study, we demonstrated a minor effect of the rs1801282 on markers of carotid atherosclerosis (presence of plaques) in Caucasians with T2DM. Moreover, we demonstrated a minor effect of the rs8192673 on CIMT progression in the 3.8-year follow-up in Caucasians with T2DM.
authors.affiliation: Department of Cardiology, University Medical Centre Ljubljana, Zaloška 2, SI-1000 Ljubljana, Slovenia.
authors.forename: Aleš
authors.initials: A
authors.lastname: Pleskovič
authors.affiliation: Department of Radiology, General Hospital Murska Sobota, Ulica Dr. Vrbnjaka 6, SI-9000 Murska Sobota, Slovenia.
authors.forename: Marija
authors.initials: M
authors.lastname: Šantl Letonja
authors.affiliation: Department of Internal Medicine, General Hospital Slovenj Gradec, Gosposvetska Cesta 1, SI-2380 Slovenj Gradec, Slovenia.
authors.forename: Andreja
authors.initials: A
authors.lastname: Cokan Vujkovac
authors.affiliation: Institute of Histology and Embryology, Faculty of Medicine, University in Ljubljana, Vrazov Trg 2, 1000 Ljubljana, Slovenia.
authors.forename: Jovana Nikolajević
authors.initials: JN
authors.lastname: Starćević
authors.affiliation: Institute of Histology and Embryology, Faculty of Medicine, University in Ljubljana, Vrazov Trg 2, 1000 Ljubljana, Slovenia; Cardiology Outpatient Department, MC Medicor, 1000 Ljubljana, Slovenia.
authors.forename: Danijel
authors.initials: D
authors.lastname: Petrovič