title: [HORMONAL-GENETIC SCREENING IN PATIENTS, SUFFERING GASTRODUODENAL ULCER HEMORRHAGE].
abstract: Genetic-hormonal regulation plays a key pathophysiologic role in a blood loss on background of complicated gastroduodenal ulcer disease, but a clinical significance of some genes of compensatory steroidogenesis remains unrevealed. Examination of 63 patients, using a chain reaction with polymerase (CRP); analysis of length of restriction fragments (CRP-RFLP) and immunohistochemical investigation of gastroduodenal mucosa were performed on the base of a Sumsky Rural Clinical Hospital. Trustworthy difference of distribution of polymorphic genes ESR1 and VKORC1 in patients of both gender in presence of the ulcer hemorrhage was not revealed, excluding genotype A/A VKORC1, what trustworthy more frequently was revealed in women (p < 0.05). There was established, that intact zone of gastric fundus owes immunoreactivity towards alpha-receptors of estrogen in nuclei of epitheliocytes and stromocytes. Diagnosis of polymorphic gene VKORC1 and expression of the estrogen receptors may serve the base for pathogenetic therapy in patients with hemorrhage occurrence.
authors.forename: I D
authors.initials: ID
authors.lastname: Duzhiy
authors.forename: A M
authors.initials: AM
authors.lastname: Romanyuk
authors.forename: M C
authors.initials: MC
authors.lastname: Lyndin
authors.forename: V V
authors.initials: VV
authors.lastname: Bratushka
authors.forename: V Yu
authors.initials: VY
authors.lastname: Dubnytskiy
authors.forename: Yu Yu
authors.initials: YY
authors.lastname: Shevchenko
authors.forename: S V
authors.initials: SV
authors.lastname: Kharchenko
mesh_terms: D000483:Alleles; D002467:Cell Nucleus / Q000378:metabolism / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D047628:Estrogen Receptor alpha / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D005787:Gene Frequency; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008297:Male; D010437:Peptic Ulcer / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010438:Peptic Ulcer Hemorrhage / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D064417:Vitamin K Epoxide Reductases / Q000235:genetics* / Q000378:metabolism
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases