title: New Labdane diterpenes from Hedychium yunnanense with cytotoxicity and inhibitory effects on nitric oxide production.
abstract: Two new labdane diterpenes, hedychenoids A (1) and B (2), were isolated from the rhizomes of Hedychium yunnanense, together with four known ones hedychenone (3), forrestin A (4), villosin (5) and calcaratarin C (6). Their structures were determined on the basis of NMR (1D and 2D) and mass spectroscopic analysis. Compounds 2, 3 and 5 exhibited cytotoxicity against SGC-7901 with IC50values of 14.88 ± 0.52, 7.08 ± 0.21 and 7.76 ± 0.21 μg/ml, 3 and 5 against HeLa with IC50values of 9.76 ± 0.48 and 13.24 ± 0.63 μg/ml, respectively. Compounds 2, 5 showed inhibitory effects against nitric oxide production in LPS and IFN-γ-induced RAW 264.7 murine macrophages with IC50values of 6.57 ± 0.88 and 5.99 ± 1.20 μg/ml, respectively.
authors.affiliation: a Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials , Yunnan Agricultural University , Kunming , P.R. China.|b School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products , Kunming Medical University , Kunming , P.R. China.
authors.forename: Yu-Peng
authors.initials: YP
authors.lastname: Li
authors.affiliation: c State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming , P.R. China.
authors.forename: Si-Meng
authors.initials: SM
authors.lastname: Zhao
authors.affiliation: a Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials , Yunnan Agricultural University , Kunming , P.R. China.
authors.forename: Jun-Ju
authors.initials: JJ
authors.lastname: Xu
authors.affiliation: c State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming , P.R. China.
authors.forename: Guang-Zhi
authors.initials: GZ
authors.lastname: Zeng
authors.affiliation: c State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming , P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: c State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming , P.R. China.
authors.forename: Ning-Hua
authors.initials: NH
authors.lastname: Tan
authors.affiliation: d Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming , P.R. China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Yang
keywords: Zingiberaceae; cytotoxicity; inhibition of NO production; labdane diterpenes