title: FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis.
abstract: Brain Positron Emission Tomography/Computed Tomography with (18)F-fluorodeoxyglucose (FDG PET/CT) was performed in a 44-year-old woman with marked cognitive impairment, diffuse myalgias, sensory, memory and visual disorders, and chronic fatigue, presenting with histopathological features of macrophagic myofasciitis (MMF) at deltoid muscle biopsy. Cerebromedullary Magnetic Resonance Imaging (MRI), electromyography, ophthalmic examination, and cerebrospinal fluid analysis were normal. Visual analysis of FDG PET/CT images showed an atypical pattern of hypometabolism, involving symmetrically the occipital cortex, temporal lobes, and limbic system (including in particular amygdalo-hippocampal complexes), and the cerebellum. Posterior cingulate cortex and parietal areas were preserved. This pattern was confirmed by a voxel-based procedure using Statistical Parametric Mapping (SPM12) that compared a patient's images to normal reference samples from six healthy subjects with adjustment to age obtained using the same PET/CT camera. These results provide a glucose metabolism substrate for cognitive complaints in patients with long-lasting aluminium hydroxide-induced MMF.
authors.affiliation: Department of Nuclear Medicine, Hôpital Henri Mondor AP-HP, Paris-Est University, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France.
authors.forename: Axel
authors.initials: A
authors.lastname: Van Der Gucht
authors.affiliation: Deparment of Neurology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, F-94010 France.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Aoun-Sebaiti
authors.affiliation: Department of Radiology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, F-94010 France.
authors.forename: Paul
authors.initials: P
authors.lastname: Kauv
authors.affiliation: Department of Nuclear Medicine, Hospital "La Timone", Assistance Publique des Hôpitaux de Marseille, Marseille, F-13000 France.
authors.forename: Eric
authors.initials: E
authors.lastname: Guedj
authors.affiliation: Department of Pathology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, F-94010 France ; Reference Center for Neuromuscular Disorders, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, F-94010 France ; INSERM U955-Team 10, Créteil, F-94010 France.
authors.forename: Jessie
authors.initials: J
authors.lastname: Aouizerate
authors.affiliation: CHU Nancy, Nuclear Medecine & Nancyclotep Experimental Imaging Platform, Nancy, F-54000 France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Verger
authors.affiliation: Department of Pathology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, F-94010 France ; Reference Center for Neuromuscular Disorders, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, F-94010 France ; INSERM U955-Team 10, Créteil, F-94010 France.
authors.forename: Romain K
authors.initials: RK
authors.lastname: Gherardi
authors.affiliation: Deparment of Neurology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, F-94010 France ; INSERM U955-Team 1, Créteil, F-94010 France.
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Bachoud-Levi
authors.affiliation: Department of Pathology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, F-94010 France ; Reference Center for Neuromuscular Disorders, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, F-94010 France ; INSERM U955-Team 10, Créteil, F-94010 France.
authors.forename: François-Jérôme
authors.initials: FJ
authors.lastname: Authier
authors.affiliation: Department of Nuclear Medicine, Hôpital Henri Mondor AP-HP, Paris-Est University, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Itti
keywords: 18F-FDG; Aluminum hydroxide; Brain imaging; Macrophagic myofasciitis