title: The effect of permissive hypotension in combined traumatic brain injury and blunt abdominal trauma: an experimental study in swines.
abstract: OBJECTIVE
  Optimal hemodynamic resuscitation strategy of the trauma patient with uncontrolled hemorrhage and severe head injury in the pre-hospital setting remains a special challenge. Permissive hypotension prior to definite surgical haemostasis promotes coagulation, decreases blood loss and favors survival. However, hypotension is associated with poor outcome in severe head injury. The purpose of this experimental animal study was to assess the impact of permissive hypotension on survival, hemodynamic profile and brain oxygenation parameters before and/or after definite surgical haemostasis.
  
  
  METHODS
  Six-week-old pigs (n=12) underwent general anesthesia and brain injury was produced by the fluid percussion model. Animals were instrumented to measure hemodynamic parameters and cerebral blood flow. All animals (n=12) were subjected to laparotomy and a surgical knot was placed through the abdominal aorta wall. Uncontrolled hemorrhage was simulated by pulling out the intentionally left protruding free ends of the suture (goal MAP=30 mmHg). Animals were randomly divided into two groups; group A (n=6) was subjected to aggressive fluid resuscitation (goal SAP >80 mmHg) and group B (n=6) was left hypotensive (permissive hypotension). Animals who survived one hour of hypotensive shock underwent definite surgical haemostasis and were resuscitated for one hour. We measured survival, hemodynamic and brain oxygenation parameters at different time points before and after surgical haemostasis.
  
  
  RESULTS
  All animals from Group A and 50% from Group B died before surgical haemostasis. In surviving animals (Group B, 50%, p=0.033), MAP, CO, rCBF, SjO2 and AVDO2 were restored to pre-procedural levels.
  
  
  CONCLUSIONS
  Permissive hypotension by delaying fluid resuscitation up to definite surgical haemostasis improves survival, hemodynamics and allows restoration of cerebral oxygenation in severe head injury.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, University Hospital of Patras, Patras, Greece. teovret@gmail.com.
authors.forename: T
authors.initials: T
authors.lastname: Vrettos
authors.forename: E
authors.initials: E
authors.lastname: Poimenidi
authors.forename: P
authors.initials: P
authors.lastname: Athanasopoulos
authors.forename: S
authors.initials: S
authors.lastname: Balasis
authors.forename: N
authors.initials: N
authors.lastname: Karagiorgos
authors.forename: T
authors.initials: T
authors.lastname: Siklis
authors.forename: G
authors.initials: G
authors.lastname: Gatzounis
authors.forename: F
authors.initials: F
authors.lastname: Fligkou
mesh_terms: D000007:Abdominal Injuries / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D000818:Animals; D000070642:Brain Injuries, Traumatic / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D004195:Disease Models, Animal; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D006439:Hemodynamics / Q000502:physiology; D006470:Hemorrhage / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D007022:Hypotension / Q000150:complications / Q000503:physiopathology*; D012151:Resuscitation / Q000379:methods; D013552:Swine; D014949:Wounds, Nonpenetrating / Q000150:complications / Q000503:physiopathology / Q000628:therapy