title: [Treatment of Rheumatoid Arthritis by Hebi Recipe: an Efficacy Observation].
abstract: OBJECTIVE
  To observe the auxiliary efficacy and safety of Hebi Recipe (HR)in treating early rheumatoid arthritis (RA).
  
  
  METHODS
  Totally 63 early RA patients with Gan-Pi disharmony were randomly assigned to the treatment group [32 cases, treated by HR (one dose per day, taken in two portions for 24 successive weeks) plus Methotrexate (MTX)] and the control group (31 cases, treated by MTX alone). The dosage of MTX was increased from 7.5 mg to 12.5 mg, once per week, 24 weeks as one course of treatment. Efficacy for Chinese medical syndromes, American College of Rheumatology 20 (ACR20) improvement rate, disease activity score in 28 joints (DAS28), laboratory related indices [ESR, rheumatoid factor (RF), C-reactive protein (CRP), anti-cyclic citrullinated peptide (CCP)], and related ultrasonic inspection items (synovium thickness, synovium blood flow classification, effusion of joint), and adverse reactions were observed.
  
  
  RESULTS
  The total effective rate (83.9%, 26/31 cases) and ACR20 improvement rate (74.2%, 23/31 cases) were higher in the treatment group than in the control group [60.7% (17/28 cases), 46.4% (13/28 cases); P < 0.05]. Compared with before treatment in the same group, DAS28 score, ESR, RF, CRP, CCP, synovium thickness, synovium blood flow classification, effusion of joint all decreased in the two groups after treatment (P < 0.01, P < 0.05). Compared with the control group after treatment, ACR20 improvement rate, DAS28 score, ESR, RF, CRP, CCP, synovium thickness, synovium blood flow classification, effusion of joint all decreased in the treatment group (P < 0.01, P < 0.05). Liver dysfunction occurred in 1 case of the treatment group. One leucopenia and 2 liver dysfunction occurred in the control group.
  
  
  CONCLUSIONS
  HR could effectively improve joints and systemic symptoms of early RA patients with Gan-Pi disharmony.
authors.forename: Ping
authors.initials: P
authors.lastname: Jiang
authors.forename: Lin-ying
authors.initials: LY
authors.lastname: Zhang
authors.forename: Ling-ling
authors.initials: LL
authors.lastname: Dai
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Jiang
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002097:C-Reactive Protein; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008727:Methotrexate; D008517:Phytotherapy; D012217:Rheumatoid Factor; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D002097:C-Reactive Protein; D012217:Rheumatoid Factor; D008727:Methotrexate