title: How does our increased understanding of the role of inflammation and innate immunity in acne impact treatment approaches?
abstract: A supplement article recently published in the Journal of the European Academy of Dermatology and Venereology by Dréno et al., members of the Global Alliance to Improve Outcomes in Acne group, summarized the data for the emerging concept that inflammation in general and the innate immune system specifically play a central role in the pathogenesis of acne. This review, entitled "Understanding innate immunity and inflammation in acne: implications for management", also discusses the impact of different treatment options on the innate immune response and inflammation. The aim of the present summary is to provide a synopsis of the key points made in the paper, from the members of the Global Alliance, as relevant to the main article within this supplement: "Recent advances in the use of adapalene 0.1%/benzoyl peroxide 2.5% to treat acne patients with moderate to severe acne".
authors.affiliation: a Department of Dermatology , University of Pennsylvania School of Medicine , Philadelphia , PA , USA.
authors.forename: James
authors.initials: J
authors.lastname: Leyden
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000068816:Adapalene / Q000008:administration & dosage; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology
chemical_list: D004338:Drug Combinations; D000068816:Adapalene; D001585:Benzoyl Peroxide
keywords: activator protein-1; antibiotic; benzoyl peroxide; retinoid; toll-like receptor