title: The Wnt7's Tale: A story of an orphan who finds her tie to a famous family.
abstract: The transformation suppressor gene RECK was isolated by cDNA expression cloning (1998), and GPR124/TEM5 was detected as a tumor endothelial marker by differential screening (2000). The importance of Wnt7a/b and Gpr124 in brain angiogenesis was demonstrated by reverse genetics in mice (2008-2010). A series of recent studies using genetically engineered mice and zebrafish as well as luciferase reporter assays in cultured cells led to the discovery of functional interactions among Reck, Gpr124, and Wnt7a/b in triggering canonical Wnt signaling with relevance to embryonic brain angiogenesis and blood-brain barrier formation.
authors.affiliation: Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Noda
authors.affiliation: Hematology Division, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Vallon
authors.affiliation: Hematology Division, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Calvin J
authors.initials: CJ
authors.lastname: Kuo
mesh_terms: D000818:Animals; D058851:GPI-Linked Proteins / Q000378:metabolism*; D006801:Humans; D018919:Neovascularization, Physiologic; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D015027:Zebrafish / Q000235:genetics / Q000378:metabolism; D029961:Zebrafish Proteins / Q000378:metabolism
chemical_list: D058851:GPI-Linked Proteins; D011518:Proto-Oncogene Proteins; C000605632:RECK protein, zebrafish; D043562:Receptors, G-Protein-Coupled; C492025:Reck protein, mouse; D051153:Wnt Proteins; C490508:Wnt7a protein, mouse; C095937:Wnt7b protein, mouse; D029961:Zebrafish Proteins; C000605631:adgra2 protein, zebrafish
keywords: Angiogenesis; Gpr124; Reck; Wnt7a/b; zebrafish