title: Mouse-Based Research on Quiescent Primate Malaria Parasites.
abstract: Mice engrafted with primate tissue make two important plasmodial dormancy-related questions researchable. The first is concerned with whether latent merozoites in the lymphatic system can give rise to relapse-like, recurrent malaria in primates. The second is that genetic evidence of hypnozoite activation as the source of relapsing primate malaria can be looked for.
authors.affiliation: School of Animal, Plant, and Environmental Sciences, Faculty of Science, University of Witwatersrand, Johannesburg, South Africa; Wits Research Institute for Malaria, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa. Electronic address: medsynth@yahoo.co.uk.
authors.forename: Miles B
authors.initials: MB
authors.lastname: Markus
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008208:Lymphatic System / Q000469:parasitology; D008288:Malaria / Q000469:parasitology*; D051379:Mice; D010961:Plasmodium / Q000235:genetics / Q000502:physiology*; D011323:Primates / Q000469:parasitology*; D012008:Recurrence; D012106:Research / Q000639:trends*
keywords: Plasmodium malariae; Plasmodium ovale; Plasmodium vivax; hypnozoite; malaria; relapse