title: Fate of Coiled Aneurysms with Minor Recanalization at 6 Months: Rate of Progression to Further Recanalization and Related Risk Factors.
abstract: Minor recanalization in coiled aneurysms may remain stable with time or may progress to major recanalization. Our aim was to monitor the aneurysms displaying minor recanalization in imaging studies at 6 months, gauging major recanalization rates and related risk factors through extended follow-up.
  
  
  
  Sixty-five aneurysms (in 65 patients) showing minor recanalization in follow-up imaging at 6 months were reviewed retrospectively. Medical records and radiologic data accruing during extended monitoring (mean, 24.8 ± 8.2 months) were assessed. Univariate and multivariate analyses were conducted to identify risk factors for progression from minor-to-major recanalization.
  
  
  
  Progression to major recanalization was observed in 24 (36.9%) of the initially qualifying aneurysms during a follow-up of 112.5 aneurysm-years, for an annual rate of 17.84% per aneurysm-year. Progression was determined chronologically as follows: 14 (58.3%) at 6 months, 8 (33.3%) at 18 months, and 2 (8.4%) at 30 months. Stent deployment significantly decreased the occurrence of major recanalization (OR = 0.22, P = .03), whereas antiplatelet therapy (OR = 0.82, P = .75), posterior location (OR = 0.24, P = .20), and second coiling for recanalized aneurysms (OR = 0.96, P = .96) were unrelated.
  
  
  
  Our analysis determined a 36.9% rate of major recanalization during a follow-up of 112.5 aneurysm-years in coiled aneurysms showing minor recanalization at 6 months. Stent deployment alone conferred a protective effect, preventing further recanalization without additional treatment. Given the fair probability of late major recanalization, aneurysms showing minor recanalization at 6 months should be monitored diligently, particularly in the absence of stent placement.
authors.affiliation: From the Department of Neurosurgery (J.P.J.), Hallym University College of Medicine, Chuncheon, Korea.
authors.forename: J P
authors.identifier: 0000-0001-8543-6855
authors.initials: JP
authors.lastname: Jeon
authors.affiliation: Departments of Radiology (Y.D.C., J.K.R., D.H.Y., M.H.H.) aronnn@empal.com.
authors.forename: Y D
authors.identifier: 0000-0002-5293-2761
authors.initials: YD
authors.lastname: Cho
authors.affiliation: Departments of Radiology (Y.D.C., J.K.R., D.H.Y., M.H.H.).
authors.forename: J K
authors.identifier: 0000-0003-2538-8374
authors.initials: JK
authors.lastname: Rhim
authors.affiliation: Departments of Radiology (Y.D.C., J.K.R., D.H.Y., M.H.H.).
authors.forename: D H
authors.identifier: 0000-0003-1658-5341
authors.initials: DH
authors.lastname: Yoo
authors.affiliation: Neurosurgery (W.s.C., H.-S.K., J.E.K.), Seoul National University College of Medicine, Seoul, Korea.
authors.forename: W-S
authors.identifier: 0000-0002-3345-8718
authors.initials: WS
authors.lastname: Cho
authors.affiliation: Neurosurgery (W.s.C., H.-S.K., J.E.K.), Seoul National University College of Medicine, Seoul, Korea.
authors.forename: H-S
authors.identifier: 0000-0002-6957-1907
authors.initials: HS
authors.lastname: Kang
authors.affiliation: Neurosurgery (W.s.C., H.-S.K., J.E.K.), Seoul National University College of Medicine, Seoul, Korea.
authors.forename: J E
authors.identifier: 0000-0002-6927-3109
authors.initials: JE
authors.lastname: Kim
authors.affiliation: Departments of Radiology (Y.D.C., J.K.R., D.H.Y., M.H.H.).
authors.forename: M H
authors.identifier: 0000-0001-5476-3482
authors.initials: MH
authors.lastname: Han
mesh_terms: D018450:Disease Progression; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000379:methods; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology* / Q000628:therapy; D008297:Male; D015999:Multivariate Analysis; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents; D016896:Treatment Outcome