title: Construction of Quaternary Stereogenic Carbon Centers through Copper-Catalyzed Enantioselective Allylic Alkylation of Azoles.
abstract: Copper-catalyzed enantioselective allylic alkylation of azoles with γ,γ-disubstituted primary allylic phosphates was achieved using a new chiral N-heterocyclic carbene ligand bearing a naphtholic hydroxy group. This reaction occurred with excellent branch regioselectivity and high enantioselectivity, thus forming a controlled all-carbon quaternary stereogenic center at the position α to the heteroaromatic ring.
authors.affiliation: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan. ohmiya@sci.hokudai.ac.jp.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Ohmiya
authors.affiliation: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan.
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Shibata
authors.affiliation: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Harada
authors.affiliation: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan. sawamura@sci.hokudai.ac.jp.
authors.forename: Masaya
authors.initials: M
authors.lastname: Sawamura
keywords: allylic compounds; asymmetric catalysis; carbenes; copper; heterocycles