title: Glycosyltransferases and non-alcoholic fatty liver disease.
abstract: Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease and its incidence is increasing worldwide. However, the underlying mechanisms leading to the development of NAFLD are still not fully understood. Glycosyltransferases (GTs) are a diverse class of enzymes involved in catalyzing the transfer of one or multiple sugar residues to a wide range of acceptor molecules. GTs mediate a wide range of functions from structure and storage to signaling, and play a key role in many fundamental biological processes. Therefore, it is anticipated that GTs have a role in the pathogenesis of NAFLD. In this article, we present an overview of the basic information on NAFLD, particularly GTs and glycosylation modification of certain molecules and their association with NAFLD pathogenesis. In addition, the effects and mechanisms of some GTs in the development of NAFLD are summarized.
authors.affiliation: Yu-Tao Zhan, Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: Zhan
authors.affiliation: Yu-Tao Zhan, Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Su
authors.affiliation: Yu-Tao Zhan, Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Wei
authors.initials: W
authors.lastname: An
mesh_terms: D000273:Adipose Tissue / Q000201:enzymology* / Q000473:pathology; D000818:Animals; D006031:Glycosylation; D016695:Glycosyltransferases / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology* / Q000473:pathology; D065626:Non-alcoholic Fatty Liver Disease / Q000201:enzymology* / Q000473:pathology; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
chemical_list: D016695:Glycosyltransferases
keywords: Glycosylation; Glycosyltransferases; Non-alcoholic fatty liver disease; Pathogenesis