title: Effects of maternal exposure to di-n-butyl phthalate during pregnancy and breastfeeding on ovarian development and function of F1 female rats.
abstract: This study aimed to investigate the effects of maternal exposure to di-n-butyl phthalate (DBP) during pregnancy and breastfeeding on F1 ovarian development and function. A rat model of maternal exposure to DBP during pregnancy and breastfeeding was established by gavage feeding female Sprague Dawley rats with 0, 10, 100, or 600mg/kg/day DBP from gestational day (GD) 12 to postnatal day (PND) 21. F1 offspring were weaned on PND21 and were not exposed to DBP afterward. The age of vaginal opening and estrus onset, estrous cyclicity, c-Kit-ligand expression on ovarian granulosa cells, and the weight of ovaries and uterus of F1 female offspring were not affected, whereas serum levels of estradiol and progesterone were increased significantly by maternal exposure to 10mg/kg/day DBP from GD12 to PND21. Although F1 ovarian function may not be adversely affected by maternal exposure to DBP, the increased reproductive hormone levels may interfere in F1 rat fertility.
authors.affiliation: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang Province, China.
authors.forename: Zuoliang
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang Province, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang Province, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Dai
authors.affiliation: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang Province, China.
authors.forename: Xubing
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang Province, China.
authors.forename: Kele
authors.initials: K
authors.lastname: Wu
authors.affiliation: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang Province, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang Province, China. Electronic address: wangqu61@126.com.
authors.forename: Yuhuan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D001942:Breast Feeding; D003993:Dibutyl Phthalate / Q000633:toxicity*; D005260:Female; D015386:Hazardous Substances / Q000633:toxicity*; D018811:Maternal Exposure; D010053:Ovary / Q000187:drug effects / Q000254:growth & development*; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015386:Hazardous Substances; D003993:Dibutyl Phthalate; D011374:Progesterone
keywords: Di-n-butyl-phthalate; Estradiol; Estrus; Kit-ligand; Progesterone; Vaginal opening