title: Malignant phyllodes tumor metastasized to the right ventricle: a case report.
abstract: Cardiac metastasis of malignant phyllodes tumor is very rare. We herein report a rare case that developed cardiac metastasis from malignant phyllodes tumor. A 38-year-old woman underwent lumpectomy, and the final pathological findings showed the 5-cm malignant phyllodes tumor partially containing 1 cm of squamous cell carcinoma. Four months after the first surgery, a local recurrence of malignant phyllodes tumor and distant metastases to the bone, lung, pulmonary main trunk, and right ventricle were detected. Mass reduction surgery of cardiac metastasis of the malignant phyllodes tumor was performed to avoid sudden death. In immunohistochemical findings, the tumor was suspected to be originated in myoepithelial cells because of the expression of smooth muscle lineage including α-smooth muscle actin and Calponin1 and highly malignant characteristics showing MIB-1 and p53 highly positive with angiogenesis. Further studies are needed to clarify the effective treatment to these tumors.
authors.affiliation: Department of Breast Surgical Oncology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan. fumi.et.hana20000119@gmail.com.
authors.forename: Fumi
authors.initials: F
authors.lastname: Yoshidaya
authors.affiliation: Department of Breast Surgical Oncology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan. naokiha@luke.ac.jp.
authors.forename: Naoki
authors.initials: N
authors.lastname: Hayashi
authors.affiliation: Department of Molecular Medicine and Pathophysiology, Osaka Medical Center for Cancer and Cardiovascular Disease, 1-3-3 Nakamichi, Higashinari-ku, Osaka, 537-8511, Japan. takahasik617@gmail.com.
authors.forename: Katsuhito
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Department of Diagnostic Pathology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan. koyusuz@luke.ac.jp.
authors.forename: Koyu
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Division of Pathology, Cancer institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. fakiyama@jfcr.or.jp.
authors.forename: Futoshi
authors.initials: F
authors.lastname: Akiyama
authors.affiliation: Department of Radiology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan. issie1009@yahoo.co.jp.
authors.forename: Mitsutomi
authors.initials: M
authors.lastname: Ishiyama
authors.affiliation: Department of Breast Surgical Oncology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan. yukotaka@luke.ac.jp.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Department of Breast Surgical Oncology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan. atsuyosi@luke.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Department of Breast Surgical Oncology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan. hyagata@gmail.com.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yagata
authors.affiliation: Department of Breast Surgical Oncology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan. seigonak@gmail.com.|Department of Breast Surgical Oncology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. seigonak@gmail.com.
authors.forename: Seigo
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Radiology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan. hirokots@luke.ac.jp.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tsunoda
authors.affiliation: Department of Breast Surgical Oncology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan. hideyama@luke.ac.jp.
authors.forename: Hideko
authors.initials: H
authors.lastname: Yamauchi
keywords: Breast; Cardiac metastasis; Debulking surgery; Malignant phyllodes tumor; Myoepithelial cells