title: Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity.
abstract: The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from monocular deprivation and stimulus-selective response potentiation (SRP) resulting from enriched visual experience. These two forms of plasticity are triggered by different events but lead to a similar increase in visual cortical response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs expressed within PV+ cells, reversibly inhibited by the psychotomimetic drug ketamine, play a critical role in SRP, but not in the induction or expression of adult OD plasticity.
authors.affiliation: Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
authors.forename: Eitan S
authors.initials: ES
authors.lastname: Kaplan
authors.affiliation: Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
authors.forename: Sam F
authors.initials: SF
authors.lastname: Cooke
authors.affiliation: Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Komorowski
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, United States.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Chubykin
authors.affiliation: Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
authors.forename: Aurore
authors.initials: A
authors.lastname: Thomazeau
authors.affiliation: Department of Neurology, Sanford Health, Fargo, United States.
authors.forename: Lena A
authors.initials: LA
authors.lastname: Khibnik
authors.affiliation: Department of Biology, Boston University, Boston, United States.
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Gavornik
authors.affiliation: Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
authors.forename: Mark F
authors.identifier: http://orcid.org/0000-0002-9903-2541
authors.initials: MF
authors.lastname: Bear
mesh_terms: D000818:Animals; D059330:GABAergic Neurons / Q000378:metabolism* / Q000502:physiology*; D051379:Mice; D009473:Neuronal Plasticity; D010320:Parvalbumins / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D014793:Visual Cortex / Q000502:physiology*
chemical_list: D010320:Parvalbumins; D016194:Receptors, N-Methyl-D-Aspartate
keywords: ketamine; mouse; neuroscience; ocular dominance plasticity; orientation-selective habituation; recognition memory; schizophrenia; stimulus-selective response potentiation