title: Mathematical modeling for local trans-round window membrane drug transport in the inner ear.
abstract: The structure and composition of the round window membrane (RWM) make it a particularly effective pathway for drug delivery to the inner ear. Therefore, predicting the efficiency of RWM transport would provide useful information for enhancing local application. In the present study, a mathematical model was established to achieve this goal. A series of drugs with different physicochemical properties were introduced in the inner ear cavity of guinea pigs via RWM by intratympanic application. The perilymphatic drug concentration (C) data were used to calculate the permeability coefficient (Kp) of different drugs diffusing through the RWM. The experimental data were fitted using the Matlab software to set up the numerical model based on Fick's diffusion law and the single-compartment model following extravascular administration, which facilitated the prediction of the permeation profiles of different drugs while trans-RWM. In summary, this mathematical model is a contribution toward developing potentially useful RWM administration simulating tools.
authors.affiliation: a School of Pharmacy, Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a School of Pharmacy, Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Huanpeng
authors.initials: H
authors.lastname: Su
authors.affiliation: a School of Pharmacy, Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wen
authors.affiliation: a School of Pharmacy, Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: a School of Pharmacy, Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods; D007758:Ear, Inner / Q000378:metabolism*; D006168:Guinea Pigs; D023421:Models, Animal; D008962:Models, Theoretical; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations
keywords: Inner ear drug delivery; mathematical model; permeability coefficient; round window membrane; topical administration