title: LIFESTAT - Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction.
abstract: OBJECTIVE
  LIFESTAT is an interdisciplinary project that leverages approaches and knowledge from medicine, the humanities and the social sciences to analyze the impact of statin use on health, lifestyle and well-being in cohorts of Danish citizens. The impetus for the study is the fact that 10% of the population in the Scandinavian countries are treated with statins in order to maintain good health and to avoid cardiovascular disease by counteracting high blood levels of cholesterol. The potential benefit of treatment with statins should be considered in light of evidence that statin use has prevalent and unintended side effects (e.g. myalgia, and glucose and exercise intolerance).
  
  
  METHODS
  The LIFESTAT project combines invasive human experiments, biomedical analyses, nationwide surveys, epidemiological studies, qualitative interviews, media content analyses, and ethnographic participant observations. The study investigates the biological consequences of statin treatment; determines the mechanism(s) by which statin use causes muscle and mitochondrial dysfunction; and analyzes achievement of treatment goals, people's perception of disease risk, media influence on people's risk and health perception, and the way people manage to live with the risk (personally, socially and technologically). CONCLUSIONS THE ORIGINALITY AND SUCCESS OF LIFESTAT DEPEND ON AND DERIVE FROM ITS INTERDISCIPLINARY APPROACH, IN WHICH THE DISCIPLINES CONVERGE INTO THOROUGH AND HOLISTIC STUDY AND DESCRIBE THE IMPACT OF STATIN USE ON THE EVERYDAY LIFE OF STATIN USERS THIS HAS THE POTENTIAL FOR MUCH GREATER BENEFIT THAN ANY ONE OF THE DISCIPLINES ALONE INTEGRATING TRADITIONAL DISCIPLINES PROVIDES NOVEL PERSPECTIVES ON POTENTIAL CURRENT AND FUTURE SOCIAL, MEDICAL AND PERSONAL BENEFITS OF STATIN USE.
authors.affiliation: Section of Film, Media and Communication, Department of Media, Cognition and Communication, Faculty of the Humanities, University of Copenhagen, Denmark.
authors.forename: Christa Lykke
authors.initials: CL
authors.lastname: Christensen
authors.affiliation: Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medicine, University of Copenhagen, Denmark.
authors.forename: Jørn
authors.initials: J
authors.lastname: Wulff Helge
authors.affiliation: Section of Health Services Research, Department of Public Health, Faculty of Health and Medicine, University of Copenhagen, Denmark.
authors.forename: Allan
authors.initials: A
authors.lastname: Krasnik
authors.affiliation: Section of Health Services Research, Department of Public Health, Faculty of Health and Medicine, University of Copenhagen, Denmark.
authors.forename: Margit
authors.initials: M
authors.lastname: Kriegbaum
authors.affiliation: Center for Healthy Aging, Department of Cellular and Molecular Medicine, Faculty of Health and Medicine, University of Copenhagen, Denmark.
authors.forename: Lene Juel
authors.initials: LJ
authors.lastname: Rasmussen
authors.affiliation: Center for Healthy Aging, Department of Cellular and Molecular Medicine, Faculty of Health and Medicine, University of Copenhagen, Denmark.
authors.forename: Ian D
authors.initials: ID
authors.lastname: Hickson
authors.affiliation: Section of Film, Media and Communication, Department of Media, Cognition and Communication, Faculty of the Humanities, University of Copenhagen, Denmark.
authors.forename: Kasper Bering
authors.initials: KB
authors.lastname: Liisberg
authors.affiliation: Department of Anthropology, Faculty of Social Sciences, University of Copenhagen, Denmark.
authors.forename: Bjarke
authors.initials: B
authors.lastname: Oxlund
authors.affiliation: Department of Anthropology, Faculty of Social Sciences, University of Copenhagen, Denmark.
authors.forename: Birgitte
authors.initials: B
authors.lastname: Bruun
authors.affiliation: Department of Anthropology, Faculty of Social Sciences, University of Copenhagen, Denmark.
authors.forename: Sofie Rosenlund
authors.initials: SR
authors.lastname: Lau
authors.affiliation: Center for Healthy Aging, Department of Cellular and Molecular Medicine, Faculty of Health and Medicine, University of Copenhagen, Denmark.
authors.forename: Maria Nathalie Angleys
authors.initials: MN
authors.lastname: Olsen
authors.affiliation: Section of General Practice, Department of Public Health, Faculty of Health and Medicine, University of Copenhagen, Denmark.
authors.forename: John Sahl
authors.initials: JS
authors.lastname: Andersen
authors.affiliation: Section of General Practice, Department of Public Health, Faculty of Health and Medicine, University of Copenhagen, Denmark.
authors.forename: Andreas Søndergaard
authors.initials: AS
authors.lastname: Heltberg
authors.affiliation: Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medicine, University of Copenhagen, Denmark.
authors.forename: Anja Birk
authors.initials: AB
authors.lastname: Kuhlman
authors.affiliation: Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medicine, University of Copenhagen, Denmark.
authors.forename: Thomas Hoffmann
authors.initials: TH
authors.lastname: Morville
authors.affiliation: Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medicine, University of Copenhagen, Denmark.
authors.forename: Tine Lovsø
authors.initials: TL
authors.lastname: Dohlmann
authors.affiliation: Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medicine, University of Copenhagen, Denmark.
authors.forename: Steen
authors.initials: S
authors.lastname: Larsen
authors.affiliation: Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medicine, University of Copenhagen, Denmark fdela@sund.ku.dk.
authors.forename: Flemming
authors.initials: F
authors.lastname: Dela
mesh_terms: D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D015331:Cohort Studies; D003718:Denmark; D058006:General Practice; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D057226:Information Seeking Behavior; D008402:Mass Media / Q000706:statistics & numerical data; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Cholesterol; general practice; media; muscle; myalgia; prevention