title: Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine.
abstract: Despite the broad anti-microbial and anti-inflammatory properties of silver nanoparticles (AgNPs), their use in bioengineered corneal replacements or bandage contact lenses has been hindered due to their intense yellow coloration. In this communication, we report the development of a new strategy to pre-stabilize and incorporate AgNPs with different colours into collagen matrices for fabrication of corneal implants and lenses, and assessed their in vitro and in vivo activity.
authors.affiliation: Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Rm H5229, Ottawa, Canada.
authors.forename: E I
authors.initials: EI
authors.lastname: Alarcon
authors.affiliation: Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Rm H5229, Ottawa, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Vulesevic
authors.affiliation: Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Rm H5229, Ottawa, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Argawal
authors.affiliation: Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Rm H5229, Ottawa, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Ross
authors.affiliation: Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Rm H5229, Ottawa, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Bejjani
authors.affiliation: Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Rm H5229, Ottawa, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Podrebarac
authors.affiliation: Department of Physics, Chemistry and Biology, Linköping University, SE 581 83 Linköping, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Ravichandran
authors.affiliation: Department of Physics, Chemistry and Biology, Linköping University, SE 581 83 Linköping, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Phopase
authors.affiliation: Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Rm H5229, Ottawa, Canada.
authors.forename: E J
authors.initials: EJ
authors.lastname: Suuronen
authors.affiliation: Integrative Regenerative Medicine Centre, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. ealarcon@ottawaheart.ca May.Griffith@liu.se.
authors.forename: M
authors.initials: M
authors.lastname: Griffith
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry; D001672:Biocompatible Materials; D003094:Collagen / Q000737:chemistry; D003315:Cornea / Q000601:surgery*; D016039:Corneal Transplantation / Q000295:instrumentation* / Q000379:methods; D020100:Hydrogels / Q000737:chemistry; D015850:Interleukin-6 / Q000378:metabolism; D007908:Lens, Crystalline / Q000601:surgery; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D050997:Nanomedicine / Q000379:methods; D044968:Regenerative Medicine / Q000379:methods*; D012834:Silver / Q000737:chemistry*; D013314:Stress, Mechanical; D013718:Tensile Strength; D054804:Cathelicidins
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D001672:Biocompatible Materials; D020100:Hydrogels; D015850:Interleukin-6; D012834:Silver; D003094:Collagen; D054804:Cathelicidins