title: A gene expression study denies the ability of 25 candidate biomarkers to predict the interferon-beta treatment response in multiple sclerosis patients.
abstract: We studied the baseline expression level of 25 interferon-regulated genes (MxA, GPR3, IL17RC, ISG15, TRAIL, OASL, IFIT1, IFIT2, RSAD2, OAS3, IFI44L, TRIM22, IL10, CXCL10, STAT1, OAS1, OAS2, IFNAR1, IFNAR2, IFNβ, ISG20, IFI6, PKR, IRF7, USP18), recurrently proposed in the literature as predictive biomarkers of interferon-beta treatment response, in whole blood of 10 "responders" and 10 "non-responders" multiple sclerosis relapsing-remitting patients, retrospectively selected on the basis of stringent clinical criteria after a five years follow-up. However, we cannot confirm the predictive value of these candidate biomarkers.
authors.affiliation: AOU San Luigi Gonzaga, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neurobiology Unit, Orbassano, TO, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, TO, Italy. Electronic address: serena.martire@gmail.com.
authors.forename: Serena
authors.initials: S
authors.lastname: Martire
authors.affiliation: AOU San Luigi Gonzaga, SCDU Medical Oncology, Orbassano, TO, Italy. Electronic address: nicolednavone@gmail.com.
authors.forename: Nicole D
authors.initials: ND
authors.lastname: Navone
authors.affiliation: AOU San Luigi Gonzaga, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neurobiology Unit, Orbassano, TO, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, TO, Italy. Electronic address: francesca.montarolo@unito.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Montarolo
authors.affiliation: AOU San Luigi Gonzaga, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neurobiology Unit, Orbassano, TO, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, TO, Italy. Electronic address: simona.perga@unito.it.
authors.forename: Simona
authors.initials: S
authors.lastname: Perga
authors.affiliation: AOU San Luigi Gonzaga, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neurobiology Unit, Orbassano, TO, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, TO, Italy. Electronic address: antonio.bertolotto@gmail.com.
authors.forename: Antonio
authors.initials: A
authors.lastname: Bertolotto
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000188:drug therapy*; D012333:RNA, Messenger / Q000378:metabolism; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D012333:RNA, Messenger; D016899:Interferon-beta
keywords: Biomarkers; Gene expression; Interferon-beta; Multiple sclerosis; Treatment response