title: Effectiveness of Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy With Versus Without Extreme Septal Hypertrophy.
abstract: OBJECTIVE
  Data on the effectiveness of alcohol septal ablation (ASA) in patients with hypertrophic cardiomyopathy (HCM) and extreme septal hypertrophy (ESH) are lacking. This study aimed to compare the effectiveness of ASA in patients with vs without ESH.
  
  
  METHODS
  Clinical profiles of 17 patients with ESH and 256 patients without ESH were compared.
  
  
  RESULTS
  Baseline pressure gradient and limiting symptoms were comparable between patients with and without ESH. At median 1.1 years of follow-up after ASA, pressure gradient was 48.5 ± 40.4 mm Hg in the ESH group and 40.9 ± 35.2 mm Hg in the non-ESH (N-ESH) group (P=.33). Patients with New York Heart Association class III/IV represented 5.9% of the ESH group and 16.9% of the N-ESH group (P=.39). Patients with Canadian Cardiovascular Society class III/IV represented 5.9% of the ESH group and 10.2% of the N-ESH group (P=.87).
  
  
  CONCLUSIONS
  The effectiveness of ASA seems comparable between patients with and without ESH.
authors.forename: Yin-Jian
authors.initials: YJ
authors.lastname: Yang
authors.affiliation: Key Laboratory of Clinical Trial Research in Cardiovascular Drugs, Ministry of Health, 167 Beilishi Rd, Xi Cheng District, Beijing, China 100037. fancm2004@126.com.
authors.forename: Chao-Mei
authors.initials: CM
authors.lastname: Fan
authors.affiliation: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 100037. yuanjinqing2013@yeah.net.
authors.forename: Jin-Qing
authors.initials: JQ
authors.lastname: Yuan
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Wang
authors.forename: Fu-Jian
authors.initials: FJ
authors.lastname: Duan
authors.forename: Shu-Bin
authors.initials: SB
authors.lastname: Qiao
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: You
authors.forename: Jian-Song
authors.initials: JS
authors.lastname: Yuan
authors.forename: Feng-Huan
authors.initials: FH
authors.lastname: Hu
authors.forename: Wei-Xian
authors.initials: WX
authors.lastname: Yang
authors.forename: Xi-Ying
authors.initials: XY
authors.lastname: Guo
authors.forename: Yi-Shi
authors.initials: YS
authors.lastname: Li
mesh_terms: D000328:Adult; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000601:surgery*; D017115:Catheter Ablation; D015150:Echocardiography, Doppler; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D006346:Heart Septum / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000431:Ethanol