title: Antibody recognition of HIV and dengue glycoproteins.
abstract: The last 6 years have witnessed an explosion of discoveries at the interface of glycobiology and immunology. Binding of clustered oligosaccharides has turned out to be a very frequent mode by which human antibodies have developed broadly neutralizing activity against HIV. This mini-review will cover many recent developments in the HIV antibody field, as well as emerging data about Dengue broadly neutralizing antibodies.
authors.affiliation: Department of Chemistry, Brandeis University, Waltham, MA 02454, USA kraussi@brandeis.edu.
authors.forename: Isaac J
authors.initials: IJ
authors.lastname: Krauss
mesh_terms: D057134:Antibodies, Neutralizing / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D000914:Antibodies, Viral / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D001665:Binding Sites; D003715:Dengue / Q000276:immunology / Q000821:virology; D003716:Dengue Virus / Q000737:chemistry* / Q000276:immunology; D000939:Epitopes / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D015699:HIV Envelope Protein gp120 / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D015658:HIV Infections / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D000072756:Protein Conformation, alpha-Helical; D000072757:Protein Conformation, beta-Strand; D054730:Protein Interaction Domains and Motifs; D014759:Viral Envelope Proteins / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D000939:Epitopes; D015699:HIV Envelope Protein gp120; D014759:Viral Envelope Proteins; C466981:glycoprotein E, dengue virus type 4
keywords: Dengue broadly neutralizing antibodies; HIV broadly neutralizing antibodies; glycoproteins; multivalency; protein–carbohydrate interactions