title: Other Proteins Involved in Parkinson's Disease and Related Disorders.
abstract: In order to explain the molecular causes of Parkinson's Disease (PD) it is important to understand the effect that mutations described as causative of the disease have at the functional level. In this special issue, several authors have been reviewing the effects in PD and other parkinsonisms of mutations described in LRRK2, α-synuclein, PINK1-Parkin-DJ-1, UCHL1, ATP13A2, GBA, VPS35, FBOX7 and HTRA2. In this review, we compile the knowledge about other proteins with a more general role in neurodegenerative diseases (MAPT) or for which less data is available due to its recent discovery (EIF4G1, DNAJC13), the lack of structural or functional data (as for PLA2G6 or DNAJC6), or even their doubtful association with the disease (as for GIGYF2, SYNJ1 and SPR). Also the cellular pathways involved in this disease are reviewed, with the goal of having an overview of the effects on the proteins and its possible role in the disease. This knowledge could also serve as the basis for designing tools that may potentially be used as a treatment for the disease, such as inhibitory or activating molecules, as well as other involved in regulating the half-life of the proteins involved.
authors.affiliation: Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas (IBV-CSIC). Calle Jaime Roig 11, Valencia E46010, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Cardona
authors.affiliation: Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas (IBV-CSIC). Calle Jaime Roig 11, Valencia E46010, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Perez-Tur
mesh_terms: D000429:Alcohol Oxidoreductases / Q000235:genetics / Q000378:metabolism; D001692:Biological Transport / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D039603:Eukaryotic Initiation Factor-4G / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D054522:Group VI Phospholipases A2 / Q000235:genetics / Q000378:metabolism; D050956:HSP40 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics / Q000378:metabolism; D009435:Synaptic Transmission / Q000235:genetics; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism; D000099182:Phosphoinositide 5-Phosphatases
chemical_list: D000429:Alcohol Oxidoreductases; D002352:Carrier Proteins; D039603:Eukaryotic Initiation Factor-4G; D054522:Group VI Phospholipases A2; D050956:HSP40 Heat-Shock Proteins; D018832:Molecular Chaperones; D010744:Phosphoric Monoester Hydrolases; D016875:tau Proteins; D000099182:Phosphoinositide 5-Phosphatases; C507525:DNAJC13 protein, human; C494652:DNAJC6 protein, human; C113920:EIF4G1 protein, human; C478016:GIGYF2 protein, human; C054369:MAPT protein, human; C022630:sepiapterin reductase; C516475:PLA2G6 protein, human
keywords: DNAJC13; DNAJC6; GIGYF2; MAPT; PARK10; PARK16; PLA2G6; SPR; SYNJ1; eIF4G1