title: Gastrointestinal Congestion Dilates the Hepatic Artery Through the P38 MAPK Signal Transduction Pathway During Liver Transplantation.
abstract: During the neohepatic stage of liver transplantation, hemodynamics change markedly. The current study aimed to investigate whether gastrointestinal congestion caused by inferior vena cava and hepatic portal vein clamping can dilate the hepatic artery and to determine the associated mechanisms. Ring segments of the hepatic artery were treated with the plasma from gastrointestinal congestion or the superior vena cava. The fractions in gastrointestinal congestion and the superior vena cava plasma were tested, and the effect of these fractions on the tone of the hepatic artery ring was examined. Different signal transduction blockers and different inhibitors were then used to determine the exact signal transduction pathway involved. In addition, endothelial cell structure was observed by transmission electron microscopy after treatment with the gastrointestinal congestion plasma or the superior vena cava plasma. Gastrointestinal congestion plasma contained more inflammatory cytokines than superior vena cava plasma, and these cytokines could cause hepatic artery ring dilatation. A P38 mitogen-activated protein kinase (P38 MAPK) signal transduction pathway blocker and nitric oxide (NO), prostaglandin (PGI2), nuclear factor-κB (NF-κB), and adenosine triphosphate (ATP)-sensitive K (KATP) channel inhibitors were able to significantly reverse the ring tension caused by gastrointestinal congestion plasma. The normal endothelium was also injured by treatment with gastrointestinal congestion plasma. The inflammatory cytokines in gastrointestinal congestion can cause hepatic artery ring dilatation through the P38 MAPK signal transduction pathway, and this phenomenon is also associated with NO, PGI2, NF-κB, and the KATP channel. These inflammatory cytokines can injure endothelial cells in the hepatic artery.
authors.affiliation: From the *Department of Anesthesia, Logistics University of Chinese People Armed Police Force Hospital, Tianjin, China; and †Department of Anesthesia, Beijing Haidian Hospital, Beijing, China.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Cao
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Tang
authors.forename: Shike
authors.initials: S
authors.lastname: Hou
mesh_terms: D016207:Cytokines / Q000502:physiology; D006499:Hepatic Artery / Q000503:physiopathology*; D006801:Humans; D016031:Liver Transplantation; D020935:MAP Kinase Signaling System / Q000502:physiology*; D011169:Portal Vein / Q000502:physiology; D014682:Vena Cava, Inferior / Q000502:physiology; D048051:p38 Mitogen-Activated Protein Kinases / Q000502:physiology*
chemical_list: D016207:Cytokines; D048051:p38 Mitogen-Activated Protein Kinases