title: Poly(vinyl alcohol) Physical Hydrogels: Matrix-Mediated Drug Delivery Using Spontaneously Eroding Substrate.
abstract: Poly(vinyl alcohol) hydrogels have a long and successful history of applications in biomedicine. Historically, these matrices were developed to be nondegradable-limiting their utility to applications as permanent implants. For tissue engineering and drug delivery, herein we develop spontaneously eroding physical hydrogels based on PVA. We characterize in detail a mild, noncryogenic method of producing PVA physical hydrogels using poly(ethylene glycol) as a gelating agent, and investigate PVA molar mass as a means to define the kinetics of erosion of these biomaterials. PVA hydrogels are characterized for associated inflammatory response in adhering macrophages, antiproliferative effects mediated through delivery of cytotoxic drugs to myoblasts, and pro-proliferative activity achieved via presentation of conjugated growth factors to endothelial cells. Together, these data present a multiangle characterization of these novel multifunctional matrices for applications in tissue engineering and drug delivery mediated by implantable biomaterials.
authors.affiliation: Department of Chemistry, Aarhus University , Aarhus, Denmark.
authors.forename: Bettina E B
authors.initials: BE
authors.lastname: Jensen
authors.affiliation: Department of Chemistry, Aarhus University , Aarhus, Denmark.
authors.forename: Izaskun
authors.initials: I
authors.lastname: Dávila
authors.affiliation: Department of Chemistry, Aarhus University , Aarhus, Denmark.|iNANO Interdisciplinary Nanoscience Center, Aarhus University , Aarhus, Denmark.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Zelikin
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D032446:Myoblasts / Q000166:cytology / Q000187:drug effects; D011092:Polyethylene Glycols / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D000067996:RAW 264.7 Cells; D023822:Tissue Engineering / Q000379:methods*; D053835:Unilamellar Liposomes / Q000737:chemistry*
chemical_list: D020100:Hydrogels; D036341:Intercellular Signaling Peptides and Proteins; D008070:Lipopolysaccharides; D053835:Unilamellar Liposomes; D011092:Polyethylene Glycols; D011142:Polyvinyl Alcohol