title: An easy and effective method for synthesis and radiolabelling of risedronate as a model for bone imaging.
abstract: This study aimed to provide an easy method for synthesis of 1-hydroxy-2-(3-pyridyl) ethylidene bisphosphonic acid monosodium (sod. risedronate) with a high yield of 71%. The synthesized risedronate was labeled with technetium-99 m using two different reducing agents (SnCl2 .2H2 O and NaBH4 ) where NaBH4 gave stable complex and higher radiochemical yield more than SnCl2 .2H2 O. The results showed that, the radiochemical purity of (99m) Tc(NaBH4 )-risedronate was 99.2 ± 0.6% and its stability was up to 6 h. Biodistribution study showed high uptake and long retention of (99m) Tc(NaBH4 )-risedronate in bone starting from 15 min (29 ± 2.5% ID/organ) up to 4 h (35.1 ± 3.2 ID/organ) post injection. This research could introduce an easy and effective method for synthesis and labeling of risedrionate and affording a good tracer for bone imaging.
authors.affiliation: Labeled Compounds Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: Motaleb
authors.affiliation: Labeled Compounds Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt.
authors.forename: A S A
authors.initials: AS
authors.lastname: Adli
authors.affiliation: Labeled Compounds Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: El-Tawoosy
authors.affiliation: Labeled Compounds Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt.
authors.forename: M H
authors.initials: MH
authors.lastname: Sanad
authors.affiliation: Faculty of Science, Department of Chemistry, Zagazig University, Zagazig, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: AbdAllah
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D001894:Borohydrides / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D004355:Drug Stability; D007553:Isotope Labeling; D007700:Kinetics; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D019163:Reducing Agents / Q000737:chemistry; D000068296:Risedronic Acid / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D013667:Technetium / Q000737:chemistry; D017971:Tin Compounds / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D001894:Borohydrides; D019275:Radiopharmaceuticals; D019163:Reducing Agents; D017971:Tin Compounds; C023599:stannous chloride; D013667:Technetium; C025364:sodium borohydride; D000068296:Risedronic Acid
keywords: 99mTc; Bisphosphonate; Bone; Imaging; Risedronate; Synthesis