title: Both slowly developing embryos and a variable pace of luteal endometrial progression may conspire to prevent normal birth in spite of a capable embryo.
abstract: Embryonic implantation requires synchrony between the endometrium and the embryo. When analyzed in isolation, competent embryos may be unsuccessful when placed on a nonreceptive endometrium or vice versa, contributing to the "black box" of implantation failure. It is when the two are assessed together that dyssynchrony becomes evident, due to premature progesterone stimulus on the endometrium, physiologic displacement of the window of implantation or late blastulation of the embryo, or all combined. From the embryonic component, detailed assessment of the timing of blastulation is essential. The molecular diagnosis of endometrial receptivity based on its transcriptomic signature could be superior to other techniques used in the past for defining the endometrial window of implantation.
authors.affiliation: Division of Reproductive Endocrinology, Department of Obstetrics Gynecology, and Reproductive Science, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey; Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Franasiak
authors.affiliation: Igenomix, Paterna, Valencia, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Ruiz-Alonso
authors.affiliation: Division of Reproductive Endocrinology, Department of Obstetrics Gynecology, and Reproductive Science, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey; Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Richard T
authors.initials: RT
authors.lastname: Scott
authors.affiliation: Igenomix, Paterna, Valencia, Spain; Department of Obstetrics and Gynecology, School of Medicine, Valencia University, and Instituto Universitario IVI/INCLIVA, Fundación Instituto Valenciano de Infertilidad, Valencia, Spain. Electronic address: carlos.simon@ivi.es.
authors.forename: Carlos
authors.initials: C
authors.lastname: Simón
mesh_terms: D000818:Animals; D010064:Embryo Implantation / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology*; D004717:Endometrium / Q000502:physiology*; D005260:Female; D006801:Humans; D008183:Luteal Phase / Q000502:physiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000378:metabolism
chemical_list: D011374:Progesterone
keywords: Receptivity; embryo; endometrium; implantation