title: Wine consumption reduced postprandial platelet sensitivity against platelet activating factor in healthy men.
abstract: OBJECTIVE
  Platelet activating factor (PAF) is a potent inflammatory and thrombotic mediator that participates in the initiation and prolongation of atherosclerosis. The aim of the present study was to evaluate the potential effect of wine consumption on platelet aggregation against PAF.
  
  
  METHODS
  The study had cross-over design. Ten healthy men participated in four daily trials on separate days: They consumed a standardized meal along with white wine, Robola variety (trial R), or red wine, Cabernet Sauvignon variety (trial CS), or an ethanol solution (trial E), or water (trial W). Blood samples were collected before and after meal consumption and at several time points during the next 6 h. Platelet aggregation against PAF (EC50values) and several blood biomarkers were measured, and incremental areas under the curve (iAUC) were calculated.
  
  
  RESULTS
  A significant trial effect was found in platelet sensitivity against PAF (ptrial= 0.01). Moreover, the iAUC-PAF EC50of CS trial was higher compared to both iAUC-PAF EC50of E and W trials (P = 0.04, P = 0.02). Plasminogen activator inhibitor-1 iAUC was higher in all alcoholic beverages compare with the one of W trial (PE= 0.05, PR= 0.01, PCS= 0.01). Triacylglycerol iAUC increased significantly only in E compared to W trial (P = 0.04) and were significantly lower at 60-120 min in wine trials compared to the one of E (P < 0.05).
  
  
  CONCLUSIONS
  Wine consumption improved platelet sensitivity independently of alcohol, kept triacylglycerols at lower levels during their postprandial elevation, and did not affect plasminogen activator inhibitor-1 levels more adversely than ethanol per se.
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671, Athens, Greece.
authors.forename: Marianna N
authors.initials: MN
authors.lastname: Xanthopoulou
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671, Athens, Greece.
authors.forename: Konstantia
authors.initials: K
authors.lastname: Kalathara
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671, Athens, Greece.
authors.forename: Sophia
authors.initials: S
authors.lastname: Melachroinou
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671, Athens, Greece.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Arampatzi-Menenakou
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671, Athens, Greece.
authors.forename: Smaragdi
authors.initials: S
authors.lastname: Antonopoulou
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671, Athens, Greece.
authors.forename: Mary
authors.initials: M
authors.lastname: Yannakoulia
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671, Athens, Greece. efragop@hua.gr.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Fragopoulou
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000166:cytology*; D015992:Body Mass Index; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D018592:Cross-Over Studies; D006801:Humans; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D010972:Platelet Activating Factor / Q000378:metabolism*; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood; D014920:Wine
chemical_list: D015415:Biomarkers; D017395:Plasminogen Activator Inhibitor 1; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; C051321:SERPINE1 protein, human; D014280:Triglycerides; D002784:Cholesterol
keywords: Alcohol; Inflammation; Microconstituents; Phenolic compounds; Postprandial; Thrombosis