title: Clinical, radiological, and pathological features of 33 adult unilateral thalamic gliomas.
abstract: BACKGROUND
  Unilateral adult thalamic gliomas are rarely reported. In this study, the authors aimed to analyze the clinical, radiological, and pathological features of adult primary unilateral thalamus gliomas (UTGs).
  
  
  METHODS
  Clinical data of 33 UTGs in adults who underwent surgical treatment between 2005 and 2014 at the Beijing Tiantan Hospital were collected and retrospectively studied. Follow-up evaluation was performed.
  
  
  RESULTS
  This study included 21 males and 12 females with a mean age of 43.1 years. The most common symptoms were headache (75.8%, 25/33 patients) and motor deficits (42.4%, 14/33 patients). Radiological results showed that enhancement was common (90.9%, 30/33 patients) and included cystic appearances in 9 cases (27.3%). All patients underwent maximal safe tumor resection. Gross total resection (GTR) was achieved in 19 cases, subtotal resection (≥80%) in 9 cases, and partial resection (<80%) in 5 cases. Molecular pathology results were available in 15 cases. After surgery, 25 patients received postoperative adjuvant therapy based on the remaining pathology. The median follow-up period of all 33 patients with UTGs was 17 months (1 week~49 months). Twenty-four patients experienced tumor recurrence. The 1-year and 2-year progression-free survival (PFS) rates were 49.0 and 10.2%, respectively. The 1-year and 2-year overall survival (OS) rates were 68.1 and 25.9%, respectively. Survival analyses revealed that several predictive factors were correlated with better prognosis, among which, GTR and tumor with cystic appearances were significantly associated with a longer survival.
  
  
  CONCLUSIONS
  Adult UTGs displayed a wide spectrum of clinical features. GTR can be achieved in adult UTGs with acceptable complications and conferred a better prognosis. Tumor with cystic appearance may indicate better prognosis. More patients and longer follow-up periods are needed to further elucidate the biological features of adult UTGs.
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, 100050, China.|Beijing Key Laboratory of Brain Tumor, Beijing, 100050, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, 100050, China.|Beijing Key Laboratory of Brain Tumor, Beijing, 100050, China.
authors.forename: Xingchao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, 100050, China.|Beijing Key Laboratory of Brain Tumor, Beijing, 100050, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Ji
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, 100050, China.|Beijing Key Laboratory of Brain Tumor, Beijing, 100050, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Neurosurgery, Beijing Puren Hospital, Beijing, 100069, China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, 100050, China.|Beijing Key Laboratory of Brain Tumor, Beijing, 100050, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Ren
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, 100050, China.|Beijing Key Laboratory of Brain Tumor, Beijing, 100050, China.
authors.forename: Guidong
authors.initials: G
authors.lastname: Song
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, 100050, China.|Beijing Key Laboratory of Brain Tumor, Beijing, 100050, China.
authors.forename: Ruofei
authors.initials: R
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, 100050, China.|Beijing Key Laboratory of Brain Tumor, Beijing, 100050, China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. gzx.tth@hotmail.com.|China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, 100050, China. gzx.tth@hotmail.com.|Beijing Key Laboratory of Brain Tumor, Beijing, 100050, China. gzx.tth@hotmail.com.
authors.forename: Zhixian
authors.initials: Z
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
keywords: Gross total resection; Prognosis; Unilateral thalamic glioma