title: Quantification of Short-Chain Chlorinated Paraffins by Deuterodechlorination Combined with Gas Chromatography-Mass Spectrometry.
abstract: Analysis of short-chain chlorinated paraffins (SCCPs) is extremely difficult because of their complex compositions with thousands of isomers and homologues. A novel analytical method, deuterodechlorination combined with high resolution gas chromatography-high resolution mass spectrometry (HRGC-HRMS), was developed. A protocol is applied in the deuterodechlorination of SCCPs with LiAlD4, and the formed deuterated n-alkanes of different alkane chains can be distinguished readily from each other on the basis of their retention time and fragment mass ([M](+)) by HRGC-HRMS. An internal standard quantification of individual SCCP congeners was achieved, in which branched C10-CPs and branched C12-CPs were used as the extraction and reaction internal standards, respectively. A maximum factor of 1.26 of the target SCCP concentrations were determined by this method, and the relative standard deviations for quantification of total SCCPs were within 10%. This method was applied to determine the congener compositions of SCCPs in commercial chlorinated paraffins and environmental and biota samples after method validation. Low-chlorinated SCCP congeners (Cl1-4) were found to account for 32.4%-62.4% of the total SCCPs. The present method provides an attractive perspective for further studies on the toxicological and environmental characteristics of SCCPs.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zou
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
authors.forename: Zhengkun
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
authors.forename: Xianbo
authors.initials: X
authors.lastname: Lu
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
authors.forename: Jiping
authors.initials: J
authors.lastname: Chen
mesh_terms: D000473:Alkanes / Q000032:analysis / Q000737:chemistry; D017607:Aluminum Compounds / Q000737:chemistry; D004784:Environmental Monitoring / Q000379:methods; D004785:Environmental Pollutants / Q000032:analysis* / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D054879:Halogenation; D006843:Hydrocarbons, Chlorinated / Q000032:analysis* / Q000737:chemistry; D018020:Lithium Compounds / Q000737:chemistry; D010232:Paraffin / Q000032:analysis* / Q000737:chemistry
chemical_list: D000473:Alkanes; D017607:Aluminum Compounds; D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D018020:Lithium Compounds; C042073:lithium aluminum hydride; D010232:Paraffin