title: Antiplasmodial activity of some phenolic compounds from Cameroonians Allanblackia.
abstract: BACKGROUND
  Plasmodium falciparum, one of the causative agents of malaria, has high adaptability through mutation and is resistant to many types of anti-malarial drugs. This study presents an in vitro assessment of the antiplasmodial activity of some phenolic compounds isolated from plants of the genus Allanblackia.
  
  
  METHODS
  Tests were performed on well plates filled with a fixed parasitized erythrocytes volume. Compounds to be tested were then added in wells. After incubation, tritiated hypoxanthine is added and the plates were returned to the incubator. After thawing, the nucleic acids are collected. Inhibitory Concentration 50 (IC50) was determined by linear interpolation.
  
  
  RESULTS
  From Allanblackia floribunda, have been isolated and characterized 1,7-dihydroxyxanthone 1, macluraxanthone 4, morelloflavone 9, Volkensiflavone 10 and morelloflavone 7-O-glucoside 11; from Allanblackia monticola, α-mangosine 2, rubraxanthone 3, allaxanthone C 5, norcowanine 6, tovophiline A 7, allaxanthone B 8 and from Allanblackia gabonensis, 1,7-dihydroxyxanthone 1. Six of them were evaluated for their antimalarial properties. The most active compound, macluraxanthone, presented a very interesting activity, with an IC50 of 0.36 and 0.27 µg/mL with the F32 and FcM29 strains respectively.
  
  
  CONCLUSIONS
  This work confirms that species of Allanblackia genus are medicinally important plants containing many biologically active compounds that can be used effectively as antiplasmodial.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Douala, P.O. Box. 24157, Douala, Cameroon.
authors.forename: Anatole Guy Blaise
authors.initials: AG
authors.lastname: Azebaze
authors.affiliation: Department of Chemistry, Faculty of Science, University of Douala, P.O. Box. 24157, Douala, Cameroon; Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, P.O. Box. 2701 Douala, Cameroon.
authors.forename: Jean Emmanuel Mbosso
authors.initials: JE
authors.lastname: Teinkela
authors.affiliation: Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, P.O. Box. 2701 Douala, Cameroon.
authors.forename: Edwige Laure
authors.initials: EL
authors.lastname: Nguemfo
authors.affiliation: Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR 152 IRD-UPS, Université Paul Sabatier, Faculté des Sciences Pharmaceutiques, 35, Chemin des Maraîchers 31062 Toulouse Cedex 4, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Valentin
authors.affiliation: Department of Animal Biology and Physiology, Faculty of Science, University of Douala, P.O. Box. 24157, Douala, Cameroon.
authors.forename: Alain Bertrand
authors.initials: AB
authors.lastname: Dongmo
authors.affiliation: Department of Chemistry, Faculty of Science, University of Douala, P.O. Box. 24157, Douala, Cameroon.
authors.forename: Juliette Catherine
authors.initials: JC
authors.lastname: Vardamides
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D044946:Biflavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D002163:Cameroon; D028084:Clusiaceae / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D008288:Malaria / Q000188:drug therapy*; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D044946:Biflavonoids; D010636:Phenols; D010936:Plant Extracts; C105620:morelloflavone
keywords: Allanblackia; Antiplasmodial activity; Guttiferaceae; Phenolic compounds