title: A comprehensive procedure for antiviral inhibitor discovery using EV71 as an example.
abstract: The prevalence of chronic viral infectious diseases, the emergence and re-emergence of new viral infections, and in particular, resistance to currently used antiviral drugs have led to increased demand for new antiviral strategies and reagents. Increased understanding of the molecular mechanisms of viral infection has provided great potential for the discovery of new antiviral agents that target viral proteins or host factors. In this work, we introduce a comprehensive system using enteroviruses 71 (EV71) as an example for leading compound discovery to develop new antiviral.
authors.affiliation: College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457 China.
authors.forename: Lin
authors.initials: L
authors.lastname: Cao
authors.affiliation: College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457 China.
authors.forename: Shouhai
authors.initials: S
authors.lastname: Zhu
authors.affiliation: National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, 100101 China.
authors.forename: Yaxin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, 100084 China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Lou
authors.affiliation: National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, 100101 China.
authors.forename: Yuna
authors.initials: Y
authors.lastname: Sun
keywords: Antiviral; Assay; Entry; Replication; Virus