title: Impact of mobilisation therapy on the haemodynamic and respiratory status of elderly intubated patients in an intensive care unit: A retrospective analysis.
abstract: OBJECTIVE
  This study identified respiratory and haemodynamic parameters affected by limited mobilisation therapy in elderly, critically ill, intubated patients in an intensive care unit.
  
  
  METHODS
  Over 18 months, we retrospectively assessed physiological changes during 43 mobilisation therapy sessions in 23 patients requiring mechanical ventilation for >48h. We compared heart rate, mean arterial blood pressure, respiratory rate, partial pressure of oxygen in arterial blood/inspired fraction of oxygen and lactate before and after mobilisation therapy, which entailed sitting on the edge of a hospital bed without back support. We analysed baseline characteristics and therapy duration.
  
  
  RESULTS
  Patients' median age was 75 (interquartile range: 65-79) years, and the median Acute Physiology and Chronic Health Evaluation II score was 27 (26-31). Average therapy duration was 1h (0.5-2h). Therapy did not significantly modify heart rate or arterial blood pressure but increased the partial pressure of oxygen in arterial blood/inspired fraction of oxygen ratio significantly, from 218.8 (135.4-271.7) to 237.3 (167.2-284.9; p=0.007), indicating improved lung function.
  
  
  CONCLUSIONS
  In this retrospective review, mobilisation therapy had no adverse effect on elderly, critically ill, intubated patients' haemodynamic status and appeared to improve the PaO2/FIO2 ratio; further research is required to confirm this finding.
authors.affiliation: Department of Intensive Care Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka 534-0021, Japan. Electronic address: gabira0517@gmail.com.
authors.forename: Nao
authors.initials: N
authors.lastname: Umei
authors.affiliation: Department of Intensive Care Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka 534-0021, Japan.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Atagi
authors.affiliation: Department of Intensive Care Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka 534-0021, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Okuno
authors.affiliation: Department of Intensive Care Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka 534-0021, Japan.
authors.forename: Seino
authors.initials: S
authors.lastname: Usuke
authors.affiliation: Department of Intensive Care Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka 534-0021, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Otsuka
authors.affiliation: Department of Intensive Care Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka 534-0021, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ujiro
authors.affiliation: Department of Intensive Care Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka 534-0021, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Shimaoka
mesh_terms: D000368:Aged; D005260:Female; D006304:Health Status; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007362:Intensive Care Units / Q000458:organization & administration; D007442:Intubation, Intratracheal / Q000009:adverse effects; D008297:Male; D056888:Patient Positioning / Q000379:methods* / Q000451:nursing / Q000592:standards*; D012137:Respiratory System / Q000503:physiopathology; D012189:Retrospective Studies
keywords: Haemodynamics; Intensive care unit; Lung function; Mobilisation