title: Disorder in Milk Proteins: α -Lactalbumin. Part A. Structural Properties and Conformational Behavior.
abstract: This is a first part of the two-part article that continues a series of reviews on the abundance and roles of intrinsic disorder in milk proteins. We introduce here α-lactalbumin, a small (Mr 14 200), simple, acidic (pI 4-5), Ca(2+)-binding protein that might constitute up to 20% of total milk protein. Although function (it is one of the two components of lactose synthase that catalyzes the final step of the lactose biosynthesis in the lactating mammary gland), structure (protein has two domains, a large α -helical domain and a small β -sheet domain connected by a calcium binding loop), and folding mechanisms (α-lactalbumin is well-known as a classic example of the molten globule state) of this model globular protein are relatively well understood, α-lactalbumin continues to surprise researchers and clearly continues to have high discovery potential. The goal of this review is to summarize some recent advances in the field of α-lactalbumin research and to analyze the peculiarities of the "intrinsic disorder code" of this protein.
authors.affiliation: Institute for Biological Instrumentation of the Russian Academy of Sciences, Institutskaya str., 7, Pushchino, Moscow region 142290, Russia. epermyak@yandex.ru.
authors.forename: Eugene A
authors.initials: EA
authors.lastname: Permyakov
authors.forename: Serge E
authors.initials: SE
authors.lastname: Permyakov
authors.forename: Leonid
authors.initials: L
authors.lastname: Breydo
authors.forename: Elrashdy M
authors.initials: EM
authors.lastname: Redwan
authors.forename: Hussein A
authors.initials: HA
authors.lastname: Almehdar
authors.affiliation: Department of Molecular Medicine, College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, MDC3540, Tampa, FL 33612, USA. vuversky@health.usf.edu.
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Uversky
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007768:Lactalbumin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D011487:Protein Conformation; D013045:Species Specificity
chemical_list: D007768:Lactalbumin