title: The association of serum trans-nonachlor levels with atherosclerosis.
abstract: Recent epidemiological studies suggest a strong association between exposure to environmental contaminants, including organochlorine (OC) insecticides or their metabolites, and development of pathologies, such as atherosclerosis, in which oxidative stress plays a significant etiological role. Biomarkers of systemic oxidative stress have the potential to link production of reactive oxygen species (ROS), which are formed as a result of exposure to xenobiotic toxicants, and underlying pathophysiological states. Measurement of F2-isoprostane concentrations in body fluids is the most accurate and sensitive method currently available for assessing in vivo steady-state oxidative stress levels. In the current study, urinary concentrations of F2-isoprostanes and serum levels of persistent OC compounds p,p'-dichlorodiphenyldichloroethene (DDE), trans-nonachlor (a component of the technical chlordane mixture), and oxychlordane (a chlordane metabolite) were quantified in a cross-sectional study sample and the association of these factors with a clinical diagnosis of atherosclerosis determined. Urinary isoprostane levels were not associated with atherosclerosis or serum concentrations of OC compounds in this study sample. However, occurrence of atherosclerosis was found to be associated with serum trans-nonachlor levels. DDE and oxychlordane were not associated with atherosclerosis. This finding supports current evidence that exposure to environmental factors is a risk factor for atherosclerosis, in addition to other known risk factors.
authors.affiliation: a Center for Environmental Health Sciences, Department of Basic Sciences , College of Veterinary Medicine, Mississippi State University, Mississippi State , Mississippi , USA.
authors.forename: Lee C
authors.initials: LC
authors.lastname: Mangum
authors.affiliation: a Center for Environmental Health Sciences, Department of Basic Sciences , College of Veterinary Medicine, Mississippi State University, Mississippi State , Mississippi , USA.
authors.forename: Lauren H
authors.initials: LH
authors.lastname: Mangum
authors.affiliation: a Center for Environmental Health Sciences, Department of Basic Sciences , College of Veterinary Medicine, Mississippi State University, Mississippi State , Mississippi , USA.
authors.forename: Janice E
authors.initials: JE
authors.lastname: Chambers
authors.affiliation: a Center for Environmental Health Sciences, Department of Basic Sciences , College of Veterinary Medicine, Mississippi State University, Mississippi State , Mississippi , USA.
authors.forename: Matthew K
authors.initials: MK
authors.lastname: Ross
authors.affiliation: a Center for Environmental Health Sciences, Department of Basic Sciences , College of Veterinary Medicine, Mississippi State University, Mississippi State , Mississippi , USA.
authors.forename: Edward C
authors.initials: EC
authors.lastname: Meek
authors.affiliation: b Department of Pathobiology and Population Medicine , College of Veterinary Medicine, Mississippi State University, Mississippi State , Mississippi , USA.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Wills
authors.affiliation: a Center for Environmental Health Sciences, Department of Basic Sciences , College of Veterinary Medicine, Mississippi State University, Mississippi State , Mississippi , USA.
authors.forename: J Allen
authors.initials: JA
authors.lastname: Crow
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000139:chemically induced / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004785:Environmental Pollutants / Q000097:blood*; D028441:F2-Isoprostanes / Q000097:blood* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood* / Q000494:pharmacology; D007306:Insecticides / Q000097:blood* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D008922:Mississippi / Q000453:epidemiology; D018384:Oxidative Stress / Q000187:drug effects; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D028441:F2-Isoprostanes; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; C001870:nonachlor