title: The Right Dorsal Premotor Mosaic: Organization, Functions, and Connectivity.
abstract: The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using meta-analytic approach applied to PMd coactivations. We compared our connectivity-based parcellation results with parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into 5 distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found 1) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory, 2) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and 3) a caudal subregion closely integrated with the motor system. Additionally, we found 4) a dorsal subregion, preferentially related to hand movements and connected to both cognitive and motor regions, and 5) a ventral subregion, whose functional profile fits the concept of an eye movement-related field. In conclusion, right PMd may be considered as a functional mosaic formed by 5 subregions.
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.|Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Genon
authors.affiliation: Brainnetome Center, Institute of Automation and.|National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Li
authors.affiliation: Brainnetome Center, Institute of Automation and.|National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Lingzhong
authors.initials: L
authors.lastname: Fan
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.|Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: Veronika I
authors.initials: VI
authors.lastname: Müller
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.|Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: Edna C
authors.initials: EC
authors.lastname: Cieslik
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Hoffstaedter
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Reid
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.|Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Langner
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.|Department of Neurology, Cologne University Hospital, Cologne, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Grefkes
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center at San Antonio, TX, USA.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.affiliation: Centre for Urban Epidemiology (CUE), Universitätsklinikum Essen, University of Duisburg-Essen, Essen, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Moebus
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.
authors.forename: Svenja
authors.initials: S
authors.lastname: Caspers
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Amunts
authors.affiliation: Brainnetome Center, Institute of Automation and.|National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.|Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, China.
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.|Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: Simon B
authors.initials: SB
authors.lastname: Eickhoff
mesh_terms: D001931:Brain Mapping; D006801:Humans; D008279:Magnetic Resonance Imaging; D009044:Motor Cortex / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000502:physiology*; D009434:Neural Pathways / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology; D012146:Rest
keywords: activation likelihood estimation; clustering; functional connectivity; parcellation; premotor cortex