title: Risk of neurodevelopmental impairment for outborn extremely preterm infants in an Australian regional network.
abstract: OBJECTIVE
  To compare neurodevelopmental outcomes at 2-3 years in extremely premature outborn and inborn infants.
  
  
  METHODS
  Population-based retrospective cohort study.
  
  
  METHODS
  Geographically defined area of New South Wales (NSW) and the Australian Capital Territory (ACT) served by a network of 10 neonatal intensive care units (NICUs).
  
  
  METHODS
  All premature infants <29 weeks gestation born between 1998 and 2004 in the setting.
  
  
  METHODS
  At 2-3 years, corrected age, 1473 children were assessed with either the Griffiths Mental Developmental Scales (GMDS) or the Bayley Scales of Infant Development (BSID-II).
  
  
  METHODS
  Moderate/severe functional disability (FD) defined as: developmental delay (GMDS general quotient (GQ) or BSID-II mental developmental index (MDI)) > 2 standard deviations (SD) below the mean; cerebral palsy (CP) requiring aids; sensorineural or conductive deafness (requiring amplification); or bilateral blindness (visual acuity <6/60 in better eye).
  
  
  RESULTS
  At 2-3 years, moderate/severe functional disability does not appear to be significantly different between outborn and inborn infants (adjusted OR 0.782; 95% CI 0.424-1.443). However, there were a significant number of outborn infants lost to follow up (23.3% versus 42.9%).
  
  
  CONCLUSIONS
  In this cohort, at 2-3 years follow up neurodevelopmental outcome does not appear to be significantly different between outborn and inborn infants. These results should be interpreted with caution given the limitation of this study.
authors.affiliation: a Medical School, College of Medicine, Biology & Environment, Australian National University , Acton, Canberra, Australian Capital Territory , Australia.
authors.forename: Kate
authors.initials: K
authors.lastname: Mahoney
authors.affiliation: b Neonatal Intensive Care Units' (NICUS) Data Collection, NSW Pregnancy and Newborn Services Network (PSN), Sydney Children's Hospitals Network , NSW , Australia.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bajuk
authors.affiliation: c Department of Newborn Care , Royal Hospital for Women , NSW , Australia.|d School of Women's and Children's Heath, University of New South Wales , NSW , Australia , and.
authors.forename: Julee
authors.initials: J
authors.lastname: Oei
authors.affiliation: c Department of Newborn Care , Royal Hospital for Women , NSW , Australia.|d School of Women's and Children's Heath, University of New South Wales , NSW , Australia , and.
authors.forename: Kei
authors.initials: K
authors.lastname: Lui
authors.affiliation: a Medical School, College of Medicine, Biology & Environment, Australian National University , Acton, Canberra, Australian Capital Territory , Australia.|e Department of Neonatology , Centenary Hospital for Women and Children , Garran, Australian Capital Territory , Australia.
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Abdel-Latif
mesh_terms: D020958:Australian Capital Territory / Q000453:epidemiology; D001766:Blindness / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D002547:Cerebral Palsy / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D002675:Child, Preschool; D003638:Deafness / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D002658:Developmental Disabilities / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D007363:Intensive Care Units, Neonatal / Q000458:organization & administration; D015931:Intensive Care, Neonatal / Q000458:organization & administration*; D016015:Logistic Models; D008297:Male; D009517:New South Wales / Q000453:epidemiology; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Inborn; low birth weight; neurodevelopment; outborn; outcome; premature