title: Efficacy and safety of Yunxiangjing derived from Chinese herbal medicine administered as an enema in the management of acute radiation-induced proctitis in patients with pelvic malignancy.
abstract: OBJECTIVE
  To assess the efficacy and safety of Yunxiangjing (YXJ), derived from Chinese herbal medicine, in the management of acute radiation-induced proctitis (ARIP) in patients with pelvic malignancy.
  
  
  METHODS
  Forty-eight patients with grade 2 ARIP were administered YXJ as an enema (1 : 30 dilution) for 2 weeks and followed up for 2 years. All were assessed for response and ARIP grade. Quality of life (QOL) was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30.
  
  
  RESULTS
  Of the 48 patients, six (12.5%) achieved complete remission of ARIP and 28 (58.3%) showed a decrease from grade 2 to grade 1 ARIP. No patient experienced a grade ≥3 toxicity. At the end of radiotherapy, patients showed significant improvements in QOL (P < 0.05). Two years after treatment, 46 patients showed no late toxicity, with only two experiencing grade 1 late toxicity.
  
  
  CONCLUSIONS
  YXJ can be used as an enema to manage acute radiation-induced proctitis in cancer patients undergoing radiotherapy. These findings suggest that YXJ enema may be an alternative treatment of ARIP.
authors.forename: Yuaying
authors.initials: Y
authors.lastname: Tang
authors.forename: Yinchun
authors.initials: Y
authors.lastname: Huang
authors.forename: Xingneng
authors.initials: X
authors.lastname: Mo
authors.forename: Guisheng
authors.initials: G
authors.lastname: Yi
authors.forename: Hui
authors.initials: H
authors.lastname: Wen
authors.forename: Zhen
authors.initials: Z
authors.lastname: Guo
authors.forename: Kaihua
authors.initials: K
authors.lastname: Feng
authors.forename: Yin
authors.initials: Y
authors.lastname: Liu
authors.forename: Qing
authors.initials: Q
authors.lastname: Bu
authors.forename: Wei
authors.initials: W
authors.lastname: JiAng
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000009:adverse effects; D004733:Enema; D005260:Female; D006801:Humans; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000532:radiotherapy*; D011349:Proctitis / Q000188:drug therapy* / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*
chemical_list: D004365:Drugs, Chinese Herbal