title: The CAR that drives Ca2+ to Orai1.
abstract: How Ca(2+) permeates the Orai1 channel and the mechanism by which the channel achieves high Ca(2+) selectivity remain critical questions in understanding store-operated Ca(2+) influx. In research published in Science Signaling, Frischauf et al. identified a Ca(2+)-accumulating region (CAR) in the extracellular opening of Orai1, which explains how concentrating Ca(2+) at the mouth of Orai1 facilitates channel permeation and contributes to selectivity.
authors.affiliation: The Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Archana
authors.initials: A
authors.lastname: Jha
authors.affiliation: The Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. shmuel.muallem@nih.gov.
authors.forename: Shmuel
authors.initials: S
authors.lastname: Muallem
mesh_terms: D000818:Animals; D002118:Calcium / Q000737:chemistry* / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D000071740:ORAI1 Protein / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D000072417:Protein Domains
chemical_list: D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; D002118:Calcium