title: Inside Out: Core Network of Transcription Factors Drives Axon Regeneration.
abstract: In this issue, Chandran et al. (2016) pursue a multi-level bioinformatics approach combined with wet bench validation to identify gene networks associated with the regenerative state of injured adult sensory neurons. A small molecular compound, ambroxol, mimics aspects of the identified gene expression patterns and promotes axon regeneration in the injured adult mouse CNS, demonstrating feasibility of in silico-based methods to identify compounds that promote neuronal growth following CNS injury.
authors.affiliation: Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
authors.forename: Choya
authors.initials: C
authors.lastname: Yoon
authors.affiliation: Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA. Electronic address: rgiger@med.umich.edu.
authors.forename: Roman J
authors.initials: RJ
authors.lastname: Giger
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D005727:Ganglia, Spinal / Q000166:cytology*; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000166:cytology*; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology*