title: [Histiocytoses: General classification and molecular criteria].
abstract: Histiocytoses are rare and heterogeneous disease sharing histology, characterized by accumulation of histiocytes. They may be inherited or sporadic, and related to the accumulation of endo- or exogenous material in macrophages or to macrophage activation. Recent discoveries have shown that some histiocytoses, such as Langerhans cell histiocytosis or Erdheim-Chester disease, previously considered as idiopathic or inflammatory were clonal myeloid proliferations. This review presents the general classification of histiocytoses, and describes diagnostic and molecular criteria of idiopathic histiocytoses and histiocytic neoplasms.
authors.affiliation: EA4340 « Biomarqueurs en cancérologie et 7 onco-hématologie », université de Versailles, université Paris-Saclay, 78035 Versailles, France; AP-HP, service de pathologie, hôpital Ambroise-Paré, 9, avenue Charles-de-Gaulle, 92104 Boulogne, France. Electronic address: jean-francois.emile@uvsq.fr.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Emile
authors.affiliation: AP-HP, hôpital de la Pitié-Salpétrière, service de pathologie, 75013 Paris, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Charlotte
authors.affiliation: Centre Léon-Bérard, service de pathologie, 69373 Lyon, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Chassagne-Clement
authors.affiliation: CHU de Lille, service de pathologie, 59037 Lille, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Copin
authors.affiliation: AP-HP, hôpital Necker, service de pathologie, 75015 Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Fraitag
authors.affiliation: AP-HP, hôpital de la Pitié-Salpétrière, service de pathologie, 75013 Paris, France.
authors.forename: Karima
authors.initials: K
authors.lastname: Mokhtari
authors.affiliation: Hôpital Ambroise-Paré, service de pathologie, 44000 Nantes, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Moreau
mesh_terms: D003937:Diagnosis, Differential; D006644:Histiocytes / Q000473:pathology*; D015614:Histiocytosis / Q000145:classification* / Q000235:genetics / Q000473:pathology*; D006801:Humans; D009154:Mutation; D009626:Terminology as Topic