title: Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review).
abstract: Alzheimer's disease affects 27 million individuals and is the most common cause of dementia worldwide. The pathology of Alzheimer's disease is primarily due to the β‑amyloid deposits and neurofibrillary tangles. These deposits exist largely in the cerebral blood vessels, but have also been shown to exist in retinal vessels. A new class of cells that were recently identified, known as melanopsin‑expressing retinal ganglion cells (mRGCs), are involved in the non‑image forming functions of the eye. These functions include circadian activities such as temperature rhythms, melatonin release and rest‑activity cycles. Circadian dysfunction has been investigated in many cases of Alzheimer's disease. In this review, we outline the current accepted Alzheimer's disease pathology, the role of mRCGs in optic neuropathies and the role of mRCGs, leading to circadian dysfunction, in Alzheimer's disease.
authors.affiliation: Department of Geriatrics, Yunnan Provincial Mental Hospital, Kunming, Yunnan 650223, P.R. China.
authors.forename: Ruiqi
authors.initials: R
authors.lastname: Feng
authors.affiliation: Administrative Office, School of Public Health, Dali University, Dali, Yunnan 671000, P.R. China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Pharmacy, Yunnan Provincial Mental Hospital, Kunming, Yunnan 650223, P.R. China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Yu
authors.affiliation: Administrative Office, School of Public Health, Dali University, Dali, Yunnan 671000, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, School of Clinical Medicine, Dali University, Dali, Yunnan 671000, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D008881:Migraine Disorders / Q000378:metabolism / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000378:metabolism*; D017299:Rod Opsins / Q000378:metabolism*; D014786:Vision Disorders / Q000378:metabolism / Q000473:pathology; D000099210:Melanopsin
chemical_list: D017299:Rod Opsins; D000099210:Melanopsin