title: Changes of ultrastructure and downregulation of heat shock protein 70 and fibroblast growth factor 2 in gastric mucosa of rats with depressive-like behaviour.
abstract: OBJECTIVE
  To understand the underlying mechanism of gastric symptoms in patients with depressive disorder.
  
  
  METHODS
  This study tested in the rat depression model evoked with chronic mild stress whether the microstructure gastric mucosa is injured using scanning electronic microscopy and transmission electronic microscopy (TEM). In addition, the expression of heat shock protein 70 (HSP70) and fibroblast growth factor 2 (FGF2) proteins in the gastric mucosa were measured by Western blotting.
  
  
  RESULTS
  We found that the gastric epithelial cells were ruptured and the gastric pits were widened in rats with depression. The amount of mucous granules was also reduced in the surface mucous cells. Moreover, parietal cells became active, and the secretory canaliculi were magnified. Expression of HSP70 and FGF2 was reduced in the gastric mucosa.
  
  
  CONCLUSIONS
  These findings suggested that gastric symptoms in rats with depressive-like behaviour were caused by the injury of the gastric mucosa, AQ1 and HSP70 and FGF2 may be key molecules in the pathogenesis.
authors.affiliation: Department of psychology, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Gonglin
authors.initials: G
authors.lastname: Hou
authors.affiliation: Department of psychology, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of psychology, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Yan
authors.affiliation: Department of psychology, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Wang