title: Pancreatic Cancer Epidemiology, Detection, and Management.
abstract: PC (pancreatic cancer) is the fourth most common cause of death due to cancer worldwide. The incidence and mortality rates have been increasing year by year worldwide, and this review has analyzed the most recent incidence and mortality data for pancreatic cancer occurrence in China. Several possible risk factors have been discussed here, involving known established risk factors and novel possible risk factors. The development of this cancer is a stepwise progression through intraepithelial neoplasia to carcinoma. Though early and accurate diagnosis is promising based on a combination of recent techniques including tumor markers and imaging modalities, lacking early clinical symptoms makes the diagnosis late. Correct staging is critical because treatment is generally based on this parameter. Treatment options have improved throughout the last decades. However, surgical excision remains the primary therapy and efficacy of conventional chemoradiotherapy for PC is limited. Recently, some novel new therapies have been developed and will be applied in clinics soon. This review will provide an overview of pancreatic cancer, including an understanding of the developments and controversies.
authors.affiliation: Department of Gastroenterology, Lihuili Hospital of Ningbo Medical Center, 57 Xingning Road, Ningbo 315040, China.
authors.forename: Qiubo
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-Sen University, 52 Meihua East Road, Zhuhai 519000, China.
authors.forename: Linjuan
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Department of Gastroenterology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou 510000, China.
authors.forename: Yinting
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou 510000, China.
authors.forename: Guoda
authors.initials: G
authors.lastname: Lian
authors.affiliation: Department of Gastroenterology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou 510000, China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Qian
authors.affiliation: Department of Gastroenterology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou 510000, China.
authors.forename: Shaojie
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou 510000, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou 510000, China.
authors.forename: Kaihong
authors.initials: K
authors.lastname: Huang