title: Lycibarbarspermidines A-O, New Dicaffeoylspermidine Derivatives from Wolfberry, with Activities against Alzheimer's Disease and Oxidation.
abstract: Fifteen new dicaffeoylspermidine derivatives, lycibarbarspermidines A-O (1-15), were isolated from the fruit of Lycium barbarum (wolfberry). The structures were unambiguously determined by spectroscopic analyses and chemical methods. Dicaffeoylspermidine derivatives, a rare kind of plant secondary metabolites, are primarily distributed in the family of Solanaceae. Only six compounds were structurally identified, and all of them are acyclic aglycones. Compounds 1-15 are the first glycosidic products of dicaffeoylspermidine derivatives, and compounds 14-15 are the first cyclization products of dicaffeoylspermidine derivatives. Moreover, dicaffeoylspermidine derivatives were first isolated and identified from wolfberry. The short-term memory assay on a transgenic fly Alzheimer's disease (AD) model showed that 1-15 exhibited different levels of anti-AD activity. The oxygen radical absorbance capacity assay revealed that 1-15 all displayed antioxidant capacity. Both anti-AD and antioxidant functions are related to the effects of wolfberry. Therefore, dicaffeoylspermidine derivatives are considered beneficial constituents responsible for the antiaging, neuroprotective, anti-AD, and antioxidant effects of wolfberry.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, ‡Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, and §Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University , Guangzhou 510632, PR China.
authors.forename: Zheng-Qun
authors.initials: ZQ
authors.lastname: Zhou
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, ‡Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, and §Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University , Guangzhou 510632, PR China.
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Fan
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, ‡Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, and §Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University , Guangzhou 510632, PR China.
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: He
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, ‡Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, and §Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University , Guangzhou 510632, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, ‡Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, and §Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University , Guangzhou 510632, PR China.
authors.forename: Bun
authors.initials: B
authors.lastname: Tsoi
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, ‡Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, and §Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University , Guangzhou 510632, PR China.
authors.forename: Kang-Hua
authors.initials: KH
authors.lastname: Lan
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, ‡Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, and §Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University , Guangzhou 510632, PR China.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kurihara
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, ‡Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, and §Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University , Guangzhou 510632, PR China.
authors.forename: Kwok-Fai
authors.initials: KF
authors.lastname: So
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, ‡Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, and §Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University , Guangzhou 510632, PR China.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, ‡Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, and §Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University , Guangzhou 510632, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D000544:Alzheimer Disease / Q000517:prevention & control*; D000975:Antioxidants; D005638:Fruit / Q000737:chemistry*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D032305:Lycium / Q000737:chemistry; D018696:Neuroprotective Agents; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species; D013095:Spermidine / Q000031:analogs & derivatives*
chemical_list: D000975:Antioxidants; D006027:Glycosides; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D013095:Spermidine
keywords: Alzheimer’s disease (AD); Lycium barbarum; antioxidant; dicaffeoylspermidine derivatives; lycibarbarspermidine; transgenic fly AD model; wolfberry