title: Irisin modulates the association of interleukin-17A with the presence of non-proliferative diabetic retinopathy in patients with type 2 diabetes.
abstract: The role of inflammation in pathogenesis of diabetic retinopathy (DR) is getting increasingly recognized. However, it is unclear whether and how non-proliferative diabetic retinopathy (NPDR) is affected by Interleukin-17A (IL-17A) and Interleukin-22 (IL-22), two well-known inflammatory factors, and irisin, a novel potential anti-inflammatory factor. Here we recruited 40 type 2 diabetes mellitus (T2DM) patients with NPDR, 60 T2DM patients without DR (no-DR), and 20 normal glucose tolerance (NGT) controls. Serum levels of IL-17A, IL-22, and irisin were examined. Compared with NGT and no-DR subjects, NPDR group had significantly higher IL-17A levels. Irisin levels were significantly lower in T2DM patients, while IL-22 levels were not significantly different across all three groups. Multiple logistic regression analysis revealed that IL-17A significantly increased the risk of NPDR (OR = 1.22, P < 0.05) before adjusting for irisin. When irisin was included in the model, neither irisin nor IL-17A was associated with NPDR. Further partial correlation analysis showed that irisin was intrinsically correlated with IL-17A even after multiple adjustment (r = -0.252; P = 0.018). These findings suggest that IL-17A is an independent risk factor of NPDR, and irisin could protect against DR through potential anti-IL-17A effects.
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Lingshu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Lin
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Liang
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Tianyi
authors.initials: T
authors.lastname: He
authors.affiliation: Division of Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, TX, 77030, USA.|Division of Endocrinology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, China. houxinguo@foxmail.com.
authors.forename: Xinguo
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, China. chenliqilu@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood*; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D007378:Interleukins / Q000097:blood; D008297:Male; D008875:Middle Aged; D000097043:Interleukin-22
chemical_list: D005353:Fibronectins; D020381:Interleukin-17; D007378:Interleukins; D000097043:Interleukin-22; C577593:FNDC5 protein, human
keywords: Interleukin-17A; Interleukin-22; Irisin; Non-proliferative diabetic retinopathy