title: Poly(ethylene glycol)-grafted cyclic acetals based polymer networks with non-water-swellable, biodegradable and surface hydrophilic properties.
abstract: Cyclic acetals based biomaterial without acidic products during hydrolytic degradation is a promising candidate for tissue engineering applications; however, low hydrophilicity is still one limitation for its biomedical application. In this work, we aim to achieve non-water-swellable cyclic acetal networks with improved hydrophilicity and surface wettability by copolymerization of cyclic acetal units based monomer, 5-ethyl-5-(hydroxymethyl)-β,β-dimethyl-1, 3-dioxane-2-ethanol diacrylate (EHD) and methoxy poly(ethylene glycol) monoacrylate (mPEGA) under UV irradiation, to avoid swelling of conventional hydrogels which could limit their applicability in particular of the mechanical properties and geometry integrity. Various EHD/mPEGA networks were fabricated with different concentrations of mPEGA from 0 to 30%, and the results showed photopolymerization behavior, mechanical property and thermal stability could not be significantly affected by addition of mPEGA, while the surface hydrophilicity was dramatically improved with the increase of mPEGA and could achieve a water contact angle of 37° with 30% mPEGA concentration. The obtained EHD/mPEGA network had comparative degradation rate to the PECA hydrogels reported previously, and MTT assay indicated it was biocompatible to L929 cells.
authors.affiliation: Complex and Intelligent Research Center, School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai, PR China. Electronic address: qdruinyan@hotmail.com.
authors.forename: Ruixue
authors.initials: R
authors.lastname: Yin
authors.affiliation: School of Materials Science and Engineering, Changzhou University, Changzhou 213164, PR China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: School of Materials Science and Engineering, Changzhou University, Changzhou 213164, PR China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Wu
authors.affiliation: School of Materials Science and Engineering, Changzhou University, Changzhou 213164, PR China. Electronic address: kemin-wang@hotmail.com.
authors.forename: Kemin
authors.initials: K
authors.lastname: Wang
mesh_terms: D000080:Acetals / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020100:Hydrogels / Q000737:chemistry*; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry* / Q000633:toxicity; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013696:Temperature; D014466:Ultraviolet Rays; D014867:Water / Q000737:chemistry; D017155:Wettability
chemical_list: D000080:Acetals; D001672:Biocompatible Materials; D020100:Hydrogels; D011108:Polymers; D014867:Water; D011092:Polyethylene Glycols
keywords: Cyclic acetals; Non-water-swellable; Pendent PEG chains; Photopolymerization