title: Statistical analyses in trials for the comprehensive understanding of organogenesis and histogenesis in humans and mice.
abstract: Statistical analyses based on the quantitative data from real multicellular organisms are useful as inductive-type studies to analyse complex morphogenetic events in addition to deductive-type analyses using mathematical models. Here, we introduce several of our trials for the statistical analysis of organogenesis and histogenesis of human and mouse embryos and foetuses. Multidimensional scaling has been applied to prove the existence and examine the mode of interkinetic nuclear migration, a regulatory mechanism of stem cell proliferation/differentiation in epithelial tubular tissues. Several statistical methods were used on morphometric data from human foetuses to establish the multidimensional standard growth curve and to describe the relation among the developing organs and body parts. Although the results are still limited, we show that these analyses are not only useful to understand the normal and abnormal morphogenesis in humans and mice but also to provide clues that could correlate aspects of prenatal developmental events with postnatal diseases.
authors.affiliation: Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan; Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan; hotani@med.shimane-u.ac.jp.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Otani
authors.affiliation: Division of Anatomy and Cell Biology, Department of Anatomy, Shiga University of Medical Science, Otsu 520-2192, Japan; and.
authors.forename: Jun
authors.initials: J
authors.lastname: Udagawa
authors.affiliation: Department of Mathematics, Shimane University, Matsue 690-8504, Japan.
authors.forename: Kanta
authors.initials: K
authors.lastname: Naito
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000196:embryology*; D006801:Humans; D051379:Mice; D038081:Organogenesis / Q000502:physiology*
keywords: histogenesis; interkinetic nuclear migration; multidimensional scaling; organogenesis; statistics