title: Hypomagnesemia linked to new-onset diabetes mellitus after kidney transplantation: A systematic review and meta-analysis.
abstract: BACKGROUND
  New-onset diabetes after kidney transplantation (NODAT) is associated with both renal allograft failure and increased mortality. The objective of this meta-analysis was to evaluate the risk of NODAT in patients with hypomagnesemia.
  
  
  METHODS
  A literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception through May, 2015. Studies that reported relative risks, odd ratios or hazard ratios comparing the risk of NODAT in patients with hypomagnesemia were included. Pooled risk ratios (RR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.
  
  
  RESULTS
  Five cohort studies with 1699 patients were included in the analysis to assess the risk of NODAT in patients with hypomagnesemia. The pooled RR of NODAT in patients with hypomagnesemia was 1.25 (95% CI, 1.08-1.45). When meta-analysis was limited only to studies with the post-transplant hypomagnesemia, the pooled RR of NODAT was 1.22 (95% CI, 1.09-1.38).
  
  
  CONCLUSIONS
  Our meta-analysis demonstrates a significant association between hypomagnesemia and NODAT in kidney transplant recipients. This finding suggests the need for a large randomized controlled trial-with very careful attention to assess the effects of normalizing Mg levels and the risk of NODAT.
authors.affiliation: a Division of Nephrology and Hypertension , Mayo Clinic , Rochester , MN , USA.
authors.forename: Wisit
authors.initials: W
authors.lastname: Cheungpasitporn
authors.affiliation: a Division of Nephrology and Hypertension , Mayo Clinic , Rochester , MN , USA.
authors.forename: Charat
authors.initials: C
authors.lastname: Thongprayoon
authors.affiliation: b Division of Diabetes, Endocrinology and Metabolism , University of Minnesota , Minneapolis , MN , USA.
authors.forename: Tasma
authors.initials: T
authors.lastname: Harindhanavudhi
authors.affiliation: c SUNY Upstate Medical University , Syracuse , NY , USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Edmonds
authors.affiliation: a Division of Nephrology and Hypertension , Mayo Clinic , Rochester , MN , USA.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Erickson
mesh_terms: D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D008275:Magnesium Deficiency / Q000453:epidemiology*
keywords: Electrolytes; graft; hypomagnesaemia; hypomagnesemia; kidney; magnesium; meta-analysis; new-onset diabetes; transplantation