title: Rumination and behavioural factors in Parkinson's disease depression.
abstract: OBJECTIVE
  Parkinson's disease is associated with high rates of depression. There is growing interest in non-pharmacological management including psychological approaches such as Cognitive Behaviour Therapy. To date, little research has investigated whether processes that underpin cognitive models of depression, on which such treatment is based, apply in patients with Parkinson's disease. The study aimed to investigate the contribution of core psychological factors to the presence and degree of depressive symptoms.
  
  
  METHODS
  104 participants completed questionnaires measuring mood, motor disability and core psychological variables, including maladaptive assumptions, rumination, cognitive-behavioural avoidance, illness representations and cognitive-behavioural responses to symptoms.
  
  
  RESULTS
  Regression analyses revealed that a small number of psychological factors accounted for the majority of depression variance, over and above that explained by overall disability. Participants reporting high levels of rumination, avoidance and symptom focusing experienced more severe depressive symptoms. In contrast, pervasive negative dysfunctional beliefs did not independently contribute to depression variance.
  
  
  CONCLUSIONS
  Specific cognitive (rumination and symptom focusing) and behavioural (avoidance) processes may be key psychological markers of depression in Parkinson's disease and therefore offer important targets for tailored psychological interventions.
authors.affiliation: King's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychology, London, UK; Department of Health and Rehabilitation Psychology, Barts Health NHS Trust, London, UK.
authors.forename: Camille L
authors.initials: CL
authors.lastname: Julien
authors.affiliation: King's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychology, London, UK.
authors.forename: Katharine A
authors.initials: KA
authors.lastname: Rimes
authors.affiliation: King's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychology, London, UK. Electronic address: richard.g.brown@kcl.ac.uk.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Brown
mesh_terms: D000339:Affect; D000368:Aged; D001362:Avoidance Learning; D015928:Cognitive Behavioral Therapy; D003863:Depression / Q000523:psychology* / Q000628:therapy; D006233:Persons with Disabilities / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000523:psychology*; D011597:Psychomotor Performance; D057566:Self Report
keywords: Avoidance; Behaviour; CBT; Depression; Parkinson's disease; Rumination