title: Stepwise development of a cancer care delivery research study to evaluate the prevalence of virus infections in cancer patients.
abstract: BACKGROUND
  SWOG initiated a cancer care delivery research study of virus infection rates among newly diagnosed cancer patients. This study will inform viral screening guidelines in oncology clinics.
  
  
  METHODS
  In a first step 'vanguard' phase, we evaluated the feasibility of multiple study procedures. Site investigators were surveyed to obtain feedback on study implementation.
  
  
  RESULTS
  Much higher enrollment occurred at sites where all physicians participated and viral testing was performed as routine practice. These procedures will be required going forward. Additional protocol changes based on site investigator input were implemented.
  
  
  CONCLUSIONS
  This multistep protocol design process illustrates how cancer care delivery research studies can adapt to real-world strategies and procedures that exist at community clinics where the predominance of cancer patients are treated.
authors.affiliation: SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Unger
authors.affiliation: Columbia University, New York, NY, USA.
authors.forename: Dawn L
authors.initials: DL
authors.lastname: Hershman
authors.affiliation: SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Kathryn B
authors.initials: KB
authors.lastname: Arnold
authors.affiliation: University of California - San Diego, La Jolla, CA, USA.
authors.forename: Rohit
authors.initials: R
authors.lastname: Loomba
authors.affiliation: University of Michigan, Ann Arbor, MI, USA.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Chugh
authors.affiliation: MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Jessica P
authors.initials: JP
authors.lastname: Hwang
authors.affiliation: NCORP of the Carolinas/Greenville Health System, Greenville, SC, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: O'Rourke
authors.affiliation: MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Nishin A
authors.initials: NA
authors.lastname: Bhadkamkar
authors.affiliation: Bay Area Institute NCORP Oakland, CA, USA.|Contra Costa Regional Medical Center, Martinez, CA, USA.
authors.forename: Lili X
authors.initials: LX
authors.lastname: Wang
authors.affiliation: Columbia University Minority Underserved NCORP, New York, NY, USA.
authors.forename: Abby B
authors.initials: AB
authors.lastname: Siegel
authors.affiliation: Boston Medical Center, Boston, MA, USA.
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Cooley
authors.affiliation: Hawaii Minority Underserved NCORP/University of Hawaii, Honolulu, HI, USA.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Berenberg
authors.affiliation: Pacific Cancer Research Consortium NCORP, Seattle, WA, USA.|St Luke's Mountain States Tumor Institute, Boise, ID, USA.
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Bridges
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Scott D
authors.initials: SD
authors.lastname: Ramsey
mesh_terms: D003695:Delivery of Health Care / Q000379:methods*; D006801:Humans; D008403:Mass Screening / Q000379:methods; D009369:Neoplasms / Q000821:virology*; D015995:Prevalence; D012107:Research Design; D014777:Virus Diseases / Q000453:epidemiology*
keywords: cancer care delivery research; screening; viral infections in cancer patients