title: Photoactivatable cytotoxic agents derived from mitochondria-targeting luminescent iridium(III) poly(ethylene glycol) complexes modified with a nitrobenzyl linkage.
abstract: Two novel photoactivatable mitochondria-targeting luminescent iridium(III) poly(ethylene glycol) (PEG) complexes incorporated with a nitrobenzyl group were designed. They showed minimal cytotoxic activity in the dark, but became significantly cytotoxic upon irradiation due to the release of the PEG pendants.
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. bhkenlo@cityu.edu.hk.
authors.forename: Karson Ka-Shun
authors.initials: KK
authors.lastname: Tso
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. bhkenlo@cityu.edu.hk.
authors.forename: Kam-Keung
authors.initials: KK
authors.lastname: Leung
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. bhkenlo@cityu.edu.hk.
authors.forename: Hua-Wei
authors.initials: HW
authors.lastname: Liu
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. bhkenlo@cityu.edu.hk and State Key Lab of Millimeter Waves, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China and Centre for Functional Photonics, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China.
authors.forename: Kenneth Kam-Wing
authors.initials: KK
authors.lastname: Lo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D007495:Iridium / Q000737:chemistry*; D049449:Luminescence; D008928:Mitochondria / Q000187:drug effects*; D009578:Nitrobenzenes / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009578:Nitrobenzenes; D011092:Polyethylene Glycols; D007495:Iridium; C036077:nitrobenzene