title: [Hemophagocytic syndrome associated to hepatitis].
abstract: Hemophagocytic syndrome is characterized by increased proliferation and activation of antigen presenting cells (histiocytes) in bone marrow and other organs of the reticuloendothelial system as well as CD8+ T cells that threatens life of patients. The predominant clinical manifestations such as fever, cytopenia, hepatitis, coagulopathy, neurological symptoms and multiple organ failure are related to systemic inflammation. We report the case of an infant who started with jaundice, abdominal pain, vomiting and malaise, at admission, hepatomegaly, splenomegaly and biochemically with features suggestive of hepatocellular inflammation and progressive cholestasis with poor outcome, it was added persistent fever, seizures, anemia, thrombocytopenia, leukopenia, elevated ferritin and hypertriglyceridemia integrating hemophagocytic syndrome with fatal outcome despite immunosuppressive therapy.
authors.affiliation: Servicio de Alergia e Inmunología Clínica Pediátrica, Hospital de Especialidades Pediátrico de León, Guanajuato, México. drasandoval83@yahoo.com.
authors.forename: Eunice
authors.initials: E
authors.lastname: Sandoval-Ramírez
authors.forename: Ignacio
authors.initials: I
authors.lastname: Camacho-Meza
authors.forename: Nery
authors.initials: N
authors.lastname: Eduardo-Solís
authors.forename: Oswaldo
authors.initials: O
authors.lastname: Plascencia-Tabares
authors.forename: Efraín
authors.initials: E
authors.lastname: Navarro-Olivos
authors.forename: Francisco Ignacio
authors.initials: FI
authors.lastname: Ortiz-Aldana
mesh_terms: D000938:Antigen-Presenting Cells; D049109:Cell Proliferation; D017809:Fatal Outcome; D006505:Hepatitis / Q000150:complications*; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications*; D013577:Syndrome
keywords: cytokine; hemophagocytosis; hepatitis; macrophage; syndrome