title: Study and application of noncatalyzed photoinduced conjugation of azides and cycloocta-1,2,3-selenadiazoles.
abstract: The non-catalyzed cycloaddition of eight structurally different azides with cyclooctyne generated in situ by the photolysis of cycloocta-1,2,3-selenadiazole gives 1,2,3-triazole derivatives as the main products. The application of this reaction was demonstrated by the photoconjugation reaction of cycloocta-1,2,3-selenadiazole with an avidin-modified biotin complex to introduce a new strategy in the non-catalyzed synthesis of bioconjugates.
authors.affiliation: Institute of Molecular and Translation Medicine, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Jedináková
authors.forename: P
authors.initials: P
authors.lastname: Šebej
authors.forename: T
authors.initials: T
authors.lastname: Slanina
authors.forename: P
authors.initials: P
authors.lastname: Klán
authors.forename: J
authors.initials: J
authors.lastname: Hlaváč