title: Intraoperative hemodynamics with vecuronium bromide and rocuronium for maintenance under general anesthesia.
abstract: OBJECTIVE
  The present study is undertaken to compare the hemodynamic effects using vecuronium versus rocuronium for maintenance in patients undergoing general surgical procedures.
  
  
  METHODS
  It is a prospective, randomized, and cohort study.
  
  
  METHODS
  100 patients were randomly divided into two groups. All patients were induced with 5 mg/kg of thiopentone sodium, and intubation conditions were achieved with 1.5 mg/kg of suxamethonium, using a well-lubricated cuffed endotracheal tube of appropriate size. When the patient started to breathe spontaneously, they were administered either 0.6 mg/kg of rocuronium (Group A) or 0.1 mg/kg of vecuronium (Group B). Hemodynamic parameters (heart rate and mean arterial pressure [MAP]) were monitored before administering the drug; at 1, 5, 10, 15, and 20 min after the drug and at the end of the surgery.
  
  
  METHODS
  Data were compiled, analyzed and presented as frequency, proportions, mean, standard deviation, percentages, and t-test using SPSS (version 16). A P < 0.05 was considered as significant.
  
  
  RESULTS
  The heart rate increased significantly at 1-min and 5-min after administration of rocuronium (83.76 ± 10.37 and 86.8 ± 9.98), unlike vecuronium. However, it gradually declined towards normal, and change in heart rate with either drug was not significant beyond 10 min. The MAP decreased significantly at 1-min after administration of rocuronium (96.68 ± 7.57) which later showed a gradual increasing trend when compared to vecuronium which had no statistically significant change at any time.
  
  
  CONCLUSIONS
  For short surgical procedures rocuronium is a good alternative to vecuronium, as the drug is reasonably cardio stable, produces excellent intubation conditions, has a shorter duration of action, and shows minimal cumulative effect.
authors.affiliation: Department of Anesthesia, KVG Medical College and Hospital, Sullia, Dakshina Kannada, Karnataka, India.
authors.forename: Alen
authors.initials: A
authors.lastname: Mathew
authors.affiliation: Department of Anesthesia, KVG Medical College and Hospital, Sullia, Dakshina Kannada, Karnataka, India.
authors.forename: Anish N G
authors.initials: AN
authors.lastname: Sharma
authors.affiliation: Department of Anesthesia, KVG Medical College and Hospital, Sullia, Dakshina Kannada, Karnataka, India.
authors.forename: P
authors.initials: P
authors.lastname: Ganapathi
authors.affiliation: Department of Anesthesia, KVG Medical College and Hospital, Sullia, Dakshina Kannada, Karnataka, India.
authors.forename: P
authors.initials: P
authors.lastname: Shankaranarayana
authors.affiliation: Department of Anesthesia, KVG Medical College and Hospital, Sullia, Dakshina Kannada, Karnataka, India.
authors.forename: M
authors.initials: M
authors.lastname: Nazim
authors.affiliation: Department of Anesthesia, KVG Medical College and Hospital, Sullia, Dakshina Kannada, Karnataka, India.
authors.forename: D S
authors.initials: DS
authors.lastname: Aiyappa
keywords: Hemodynamic changes; rocuronium; vecuronium