title: Broad taxonomic characterization of Verticillium wilt resistance genes reveals an ancient origin of the tomato Ve1 immune receptor.
abstract: Plant-pathogenic microbes secrete effector molecules to establish themselves on their hosts, whereas plants use immune receptors to try and intercept such effectors in order to prevent pathogen colonization. The tomato cell surface-localized receptor Ve1 confers race-specific resistance against race 1 strains of the soil-borne vascular wilt fungus Verticillium dahliae which secrete the Ave1 effector. Here, we describe the cloning and characterization of Ve1 homologues from tobacco (Nicotiana glutinosa), potato (Solanum tuberosum), wild eggplant (Solanum torvum) and hop (Humulus lupulus), and demonstrate that particular Ve1 homologues govern resistance against V. dahliae race 1 strains through the recognition of the Ave1 effector. Phylogenetic analysis shows that Ve1 homologues are widely distributed in land plants. Thus, our study suggests an ancient origin of the Ve1 immune receptor in the plant kingdom.
authors.affiliation: Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708 PB, Wageningen, the Netherlands.
authors.forename: Yin
authors.initials: Y
authors.lastname: Song
authors.affiliation: Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708 PB, Wageningen, the Netherlands.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708 PB, Wageningen, the Netherlands.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Seidl
authors.affiliation: Biotechnical Faculty, Agronomy Department, Centre for Plant Biotechnology and Breeding, University of Ljubljana, Jamnikarieva 101, 1000, Ljubljana, Slovenia.
authors.forename: Aljaz
authors.initials: A
authors.lastname: Majer
authors.affiliation: Biotechnical Faculty, Agronomy Department, Centre for Plant Biotechnology and Breeding, University of Ljubljana, Jamnikarieva 101, 1000, Ljubljana, Slovenia.
authors.forename: Jernej
authors.initials: J
authors.lastname: Jakse
authors.affiliation: Biotechnical Faculty, Agronomy Department, Centre for Plant Biotechnology and Breeding, University of Ljubljana, Jamnikarieva 101, 1000, Ljubljana, Slovenia.
authors.forename: Branka
authors.initials: B
authors.lastname: Javornik
authors.affiliation: Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708 PB, Wageningen, the Netherlands.
authors.forename: Bart P H J
authors.initials: BP
authors.lastname: Thomma
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D003001:Cloning, Molecular; D060467:Disease Resistance / Q000235:genetics*; D019143:Evolution, Molecular; D005656:Fungal Proteins / Q000378:metabolism; D017343:Genes, Plant; D018551:Solanum lycopersicum / Q000235:genetics / Q000382:microbiology*; D010802:Phylogeny; D010935:Plant Diseases / Q000235:genetics* / Q000382:microbiology*; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D030821:Plants, Genetically Modified; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D032322:Solanum / Q000382:microbiology; D011198:Solanum tuberosum / Q000382:microbiology; D014026:Nicotiana / Q000276:immunology / Q000382:microbiology; D020172:Verticillium / Q000502:physiology*
chemical_list: D005656:Fungal Proteins; D010940:Plant Proteins; D011971:Receptors, Immunologic
keywords: Ave1 effector; RLP; Verticillium dahliae; leucine-rich repeat; receptor-like protein