title: Deconstructing Dietary Restriction: A Case for Systems Approaches in Aging.
abstract: Dietary restriction is a robust and conserved intervention to slow aging and extend lifespan. In this issue of Cell Metabolism, Hou et al. (2016) use a systems biology approach in C. elegans to uncover key molecular nodes underlying the transcriptomic response to dietary restriction and predict novel regulators of lifespan.
authors.affiliation: Department of Genetics, Stanford University, Stanford, CA 94305, USA; Genetics Graduate Program, Stanford University, Stanford, CA 94305, USA.
authors.forename: Robin
authors.initials: R
authors.lastname: Yeo
authors.affiliation: Department of Genetics, Stanford University, Stanford, CA 94305, USA; Glenn Laboratories for the Biology of Aging, Stanford University, Stanford, CA 94305, USA. Electronic address: abrunet1@stanford.edu.
authors.forename: Anne
authors.initials: A
authors.lastname: Brunet
mesh_terms: D000375:Aging; D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D031204:Caloric Restriction; D006801:Humans; D008136:Longevity
chemical_list: D029742:Caenorhabditis elegans Proteins