title: Bone Age and Serum Osteocalcin Levels in Children With Obstructive Sleep Apnea Hypopnea Syndrome Before and After Adenotonsillectomy.
abstract: Our aim was to study the changes in bone age and serum osteocalcin levels before and after adenotonsillectomy (AT) in children with obstructive sleep apnea hypopnea syndrome (OSAHS). A total of 58 OSAHS children (37 males and 21 females) with the mean age of 6.68 ± 1.11 years were enrolled and assessed by x-ray-based bone age estimation and enzyme-linked immunosorbent assay-based measurement of serum osteocalcin levels, before surgery and 6 months after AT. SPSS 19.0 software was used for statistical analysis. Our results revealed that bone age and serum osteocalcin levels in OSAHS patients were significantly lower than normal controls before AT (P < 0.05). Within 6 months after surgery, the bone age and the serum osteocalcin levels were significantly elevated in OSAHS patients (P < 0.05), compared with those before surgery. Serum osteocalcin levels and bone age are negatively correlated with apnea-hypopnea index, oxygen desaturation index, the percentage of the total recorded time spent below 90% oxygen saturation, and Epworth sleepiness scale scores (all P < 0.05). Our findings suggested that bone age and serum osteocalcin levels may be correlated with the development of OSAHS in children. AT may improve bone age and serum osteocalcin levels in OSAHS children.
authors.affiliation: 1Department of Otorhinolaryngology, the Second Hospital of Shandong University, Jinan, China; and 2Department of Orthopedic Surgery, the First Hospital of Jinan, Jinan, China.
authors.forename: Hui-Wei
authors.initials: HW
authors.lastname: Feng
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Tian
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Jia
authors.forename: Hai-Ling
authors.initials: HL
authors.lastname: Zhang
authors.forename: Xian-Liang
authors.initials: XL
authors.lastname: Fan
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Chen
authors.forename: Feng-Lei
authors.initials: FL
authors.lastname: Xu
mesh_terms: D000233:Adenoidectomy; D000365:Age Determination by Skeleton; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D015675:Osteocalcin / Q000097:blood*; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000601:surgery; D014068:Tonsillectomy; D016896:Treatment Outcome
chemical_list: D015675:Osteocalcin