title: 9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner.
abstract: Single nucleotide polymorphisms from the chromosome locus 9p21 are reported to carry a risk for various cardiovascular diseases. One of the lead single nucleotide polymorphisms, rs10757278, was mostly investigated in association with coronary artery disease but rarely with carotid atherosclerosis. In this study, we aimed to analyze the association of rs10757278 A/G polymorphism with carotid plaque presence in advanced carotid atherosclerosis. The study included 803 participants, 486 patients with high-grade stenosis (>70%) who were undergoing carotid endarterectomy and 317 controls from Serbian population. Genotypes were determined using the real-time polymerase chain reaction. According to the recessive model of inheritance, GG genotype was significantly and independently associated with carotid plaque in females only (odds ratio 2.42, CI = 1.20-4.90, P = 0.013). Odds ratio was adjusted for age, body mass index, hypertension, TC, LDLC, HDLC and TG, and P value was corrected for multiple comparisons. Our preliminary findings suggest a gender-specific association of rs10757278 polymorphism with carotid plaque. Further studies on larger sample and in genetically and environmentally similar populations are needed.
authors.affiliation: Laboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Zivotić
authors.affiliation: Laboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Tamara
authors.initials: T
authors.lastname: Djurić
authors.affiliation: Laboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Stanković
authors.affiliation: Laboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Djordjević
authors.affiliation: Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia Clinic for the Vascular and Endovascular Surgery, Clinical Center of Serbia, 11000 Belgrade, Serbia.
authors.forename: Igor
authors.initials: I
authors.lastname: Končar
authors.affiliation: Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia Clinic for the Vascular and Endovascular Surgery, Clinical Center of Serbia, 11000 Belgrade, Serbia.
authors.forename: Lazar
authors.initials: L
authors.lastname: Davidović
authors.affiliation: Laboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Dragan
authors.initials: D
authors.lastname: Alavantić
authors.affiliation: Laboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences, University of Belgrade, 11000 Belgrade, Serbia majaz@vinca.rs.
authors.forename: Maja
authors.initials: M
authors.lastname: Zivković
mesh_terms: D000328:Adult; D000368:Aged; D002340:Carotid Artery Diseases / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction; D055771:Serbia / Q000453:epidemiology; D012737:Sex Factors
keywords: 9p21; carotid plaque; gender specific; gene polymorphism; rs10757278