title: Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.
abstract: Intravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical challenge. Herein we report on the production and the characterization of gold surfaces covalently derivatized with the peptide α-alpha-melanocyte stimulating hormone (α-MSH), with a quantifiable surface density. In vitro study demonstrated that the tethered α-MSH is able to decrease the expression of an inflammatory cytokine produced by endothelial cells.
authors.affiliation: Univ. Bordeaux, CBMN, UMR 5248, F-33600, Pessac, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Le Saux
authors.affiliation: Univ. Bordeaux, CBMN, UMR 5248, F-33600, Pessac, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Plawinski
authors.affiliation: Univ. Bordeaux, CBMN, UMR 5248, F-33600, Pessac, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Nlate
authors.affiliation: Univ. Bordeaux, BIOTIS, INSERM U1026, F-33076, Bordeaux, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Ripoche
authors.affiliation: Univ. Bordeaux, ISM, UMR 5255, F-33400, Talence, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Buffeteau
authors.affiliation: Univ. Bordeaux, CBMN, UMR 5248, F-33600, Pessac, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Durrieu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation* / Q000379:methods; D002448:Cell Adhesion; D004563:Electrochemistry; D042783:Endothelial Cells / Q000166:cytology; D005947:Glucose / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D006868:Hydrolysis; D007249:Inflammation; D015850:Interleukin-6 / Q000737:chemistry; D008070:Lipopolysaccharides / Q000737:chemistry; D008301:Maleimides / Q000737:chemistry; D008856:Microscopy, Fluorescence; D010455:Peptides / Q000737:chemistry; D019736:Prostheses and Implants; D013052:Spectrometry, X-Ray Emission; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013499:Surface Properties; D000521:alpha-MSH / Q000378:metabolism*
chemical_list: D001672:Biocompatible Materials; D015850:Interleukin-6; D008070:Lipopolysaccharides; D008301:Maleimides; D010455:Peptides; D013438:Sulfhydryl Compounds; C043592:maleimide; D000521:alpha-MSH; D006046:Gold; D005947:Glucose