title: Transcriptional enhancers: Transcription, function and flexibility.
abstract: Active transcriptional enhancers are often transcribed to eRNAs, whose changing levels mirror those of the target gene mRNA. We discuss some of the reported functions of these eRNAs and their likely diversity to allow utilization of distinct cis regulatory regions to enhance transcription in diverse developmental and cellular contexts.
authors.affiliation: a Faculty of Biology, Technion-Israel Institute of Technology , Haifa , Israel.
authors.forename: Philippa
authors.initials: P
authors.lastname: Melamed
authors.affiliation: a Faculty of Biology, Technion-Israel Institute of Technology , Haifa , Israel.
authors.forename: Yahav
authors.initials: Y
authors.lastname: Yosefzon
authors.affiliation: a Faculty of Biology, Technion-Israel Institute of Technology , Haifa , Israel.
authors.forename: Sergei
authors.initials: S
authors.lastname: Rudnizky
authors.affiliation: a Faculty of Biology, Technion-Israel Institute of Technology , Haifa , Israel.
authors.forename: Lilach
authors.initials: L
authors.lastname: Pnueli
mesh_terms: D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D006657:Histones / Q000378:metabolism; D006801:Humans; D008745:Methylation; D011401:Promoter Regions, Genetic; D012313:RNA / Q000737:chemistry* / Q000235:genetics; D024363:Transcription Initiation Site; D014158:Transcription, Genetic
chemical_list: D006657:Histones; D012313:RNA
keywords: chromatin; eRNA; enhancer; histone modification; non-coding RNA; promoter; transcription