title: Membrane traffic during axon development.
abstract: Brain formation requires the establishment of complex neural circuits between a diverse array of neuronal subtypes in an intricate and ever changing microenvironment and yet with a large degree of specificity and reproducibility. In the last three decades, mounting evidence has established that neuronal development relies on the coordinated regulation of gene expression, cytoskeletal dynamics, and membrane trafficking. Membrane trafficking has been considered important in that it brings new membrane and proteins to the plasma membrane of developing neurons and because it also generates and maintains the polarized distribution of proteins into neuronal subdomains. More recently, accumulating evidence suggests that membrane trafficking may have an even more active role during development by regulating the distribution and degree of activation of a wide variety of proteins located in plasma membrane subdomains and endosomes. In this article the evidence supporting the different roles of membrane trafficking during axonal development, particularly focusing on the role of SNAREs and Rabs was reviewed. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1185-1200, 2016.
authors.affiliation: Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, CNRS UMR 7592, Membrane Traffic in Health & Disease, INSERM ERL U950, Paris, F-75013, France.
authors.forename: José
authors.initials: J
authors.lastname: Wojnacki
authors.affiliation: Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, CNRS UMR 7592, Membrane Traffic in Health & Disease, INSERM ERL U950, Paris, F-75013, France. thierry.galli@inserm.fr.
authors.forename: Thierry
authors.initials: T
authors.lastname: Galli
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D021381:Protein Transport / Q000502:physiology*; D050600:SNARE Proteins / Q000378:metabolism*; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D050600:SNARE Proteins; D020691:rab GTP-Binding Proteins
keywords: Rab; SNARE; axonal plasticity; membrane traffic; neuronal development