title: [Fatal pneumococcal meningitis due to serotype 19 A: A preventable case?].
abstract: Invasive pneumococcal disease (IPD) remains as an important cause of morbidity in the world and in our country, while in Chile the incidence has decreased after the incorporation of the 10 valent pneumococcal conjugate vaccine, in the routine infant inmunization schedule (EPI). One of the expected effects of the program after vaccination with 10-valent pneumococcal vaccine is the likely replacement serotype phenomenon that means the presence of ENI caused by serotypes not included in the vaccine. In this context, we present the case of a child with pneumococcal meningitis caused by serotype 19 A of fatal course. The occurrence of ENI in a later stage of pneumococcal vaccine incorporation in Chile reinforces the importance of active surveillance, in order to know in detail the impact of vaccination, distribution of circulating serotypes and their correlation with the different clinical disease and their severity.
authors.forename: M Carolina
authors.initials: MC
authors.lastname: Rivacoba
authors.forename: José
authors.initials: J
authors.lastname: Cofré
authors.forename: M Elena
authors.initials: ME
authors.lastname: Santolaya
mesh_terms: D002675:Child, Preschool; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008586:Meningitis, Pneumococcal / Q000175:diagnosis* / Q000188:drug therapy; D022242:Pneumococcal Vaccines / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification
chemical_list: C538863:10-valent pneumococcal vaccine; D022242:Pneumococcal Vaccines