title: Irisin immunohistochemistry in gastrointestinal system cancers.
abstract: Cancer is the leading cause of morbidity and mortality worldwide. Some studies have shown that high heat kills cancer cells. Irisin is a protein involved in heat production by converting white into brown adipose tissue, but there is no information about how its expression changes in cancerous tissues. We used irisin antibody immunohistochemistry to investigate changes in irisin expression in gastrointestinal cancers compared to normal tissues. Irisin was found in human brain neuroglial cells, esophageal epithelial cells, esophageal epidermoid carcinoma, esophageal adenocarcinoma and neuroendocrine esophageal carcinoma, gastric glands, gastric adenosquamous carcinoma, gastric neuroendocrine carcinoma, gastric signet ring cell carcinoma, neutrophils in vascular tissues, intestinal glands of colon, colon adenocarcinoma, mucinous colon adenocarcinoma, hepatocytes, hepatocellular carcinoma, islets of Langerhans, exocrine pancreas, acinar cells and interlobular and interlobular ducts of normal pancreas, pancreatic ductal adenocarcinoma, and intra- and interlobular ducts of cancerous pancreatic tissue. Histoscores (area × intensity) indicated that irisin was increased significantly in gastrointestinal cancer tissues, except liver cancers. Our findings suggest that the relation of irisin to cancer warrants further investigation.
authors.affiliation: a Firat University, School of Medicine , Department of Medical Biochemistry (Firat Hormones Research Group) , Elazig , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Aydin
authors.affiliation: b Firat University, School of Medicine , Department of Histology and Embryology , Elazig , Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Kuloglu
authors.affiliation: c Firat University, School of Medicine , Department of Pathology , Elazig , Turkey.
authors.forename: M R
authors.initials: MR
authors.lastname: Ozercan
authors.affiliation: d Elazig Education and Research Hospital , Department of Neurosurgery , Elazig , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Albayrak
authors.affiliation: e Firat University, School of Medicine , Department of Anatomy , Elazig , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Aydin
authors.affiliation: f Firat University, School of Medicine , Department of Pediatric Surgery , Elazig , Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Bakal
authors.affiliation: a Firat University, School of Medicine , Department of Medical Biochemistry (Firat Hormones Research Group) , Elazig , Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Yilmaz
authors.affiliation: g Laboratory of Medical Biochemistry, Elazig Education and Research Hospital , Elazig , Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kalayci
authors.affiliation: a Firat University, School of Medicine , Department of Medical Biochemistry (Firat Hormones Research Group) , Elazig , Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Yardim
authors.affiliation: f Firat University, School of Medicine , Department of Pediatric Surgery , Elazig , Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Sarac
authors.affiliation: f Firat University, School of Medicine , Department of Pediatric Surgery , Elazig , Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Kazez
authors.affiliation: h Dokuz Eylul University, School of Medicine , Department of Medical Biochemistry , İzmir , Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Kocdor
authors.affiliation: i Elazig Education and Research Hospital , Department of General Surgery , Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Kanat
authors.affiliation: c Firat University, School of Medicine , Department of Pathology , Elazig , Turkey.
authors.forename: İ H
authors.initials: İH
authors.lastname: Ozercan
authors.affiliation: j Firat University, School of Medicine , Department of Neurology , Elazig , Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Gonen
authors.affiliation: k Oslo University, School of Medicine , Oslo , Norway.
authors.forename: M
authors.initials: M
authors.lastname: Bilgen
authors.affiliation: j Firat University, School of Medicine , Department of Neurology , Elazig , Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Balgetir
mesh_terms: D005353:Fibronectins / Q000235:genetics* / Q000378:metabolism*; D005770:Gastrointestinal Neoplasms / Q000503:physiopathology*; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins
keywords: cancer; gastrointestinal system; immunohistochemistry; irisin