title: [Effects of Intensity of Acting Agents on the Manifestation of Synergistic Interaction].
abstract: The universal dependence of the synergistic interaction on the intensity of the acting agents was demonstrated. This dependence is not associated with the biological object, as well as the nature of the physical or chemical agents used in the combined exposures. In all cases, with a decrease in the intensity of one of the agents the intensity of the other factor should be also decreased to ensure the greatest synergistic effect. Such relationship of synergy and the intensity of the acting agents is of interest for radiation safety. This regularity indicates the principal possibility of synergistic interaction of harmful environmental factors actually occurring in the biosphere at their low intensities.
authors.forename: V G
authors.initials: VG
authors.lastname: Petin
authors.forename: G P
authors.initials: GP
authors.lastname: Zhurakovskaya
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D002945:Cisplatin / Q000494:pharmacology; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004785:Environmental Pollutants / Q000494:pharmacology; D006358:Hot Temperature; D008954:Models, Biological; D011839:Radiation, Ionizing; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000528:radiation effects*; D014466:Ultraviolet Rays; D019287:Zinc Sulfate / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D004785:Environmental Pollutants; D019287:Zinc Sulfate; D002945:Cisplatin