title: A Review on Platensimycin: A Selective FabF Inhibitor.
abstract: Emerging resistance to existing antibiotics is an inevitable matter of concern in the treatment of bacterial infection. Naturally occurring unique class of natural antibiotic, platensimycin, a secondary metabolite from Streptomyces platensis, is an excellent breakthrough in recent antibiotic research with unique structural pattern and significant antibacterial activity. β-Ketoacyl-(acyl-carrier-protein (ACP)) synthase (FabF) whose Gram-positive bacteria need to biosynthesize cell membranes is the target of inhibition of platensimycin. So, isolation, retrosynthetic analysis, synthesis of platensimycin, and analogues of platensimycin synthesized till today are the objectives of this review which may be helpful to further investigate and to reveal untouched area on this molecule and to obtain a potential antibacterial lead with enhanced significant antibacterial activity.
authors.affiliation: Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura 799022, India.
authors.forename: Manik
authors.identifier: 0000-0001-5739-4870
authors.initials: M
authors.lastname: Das
authors.affiliation: Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura 799022, India.
authors.forename: Partha
authors.initials: P
authors.lastname: Sakha Ghosh
authors.affiliation: Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura 799022, India.
authors.forename: Kuntal
authors.initials: K
authors.lastname: Manna