title: Bipolar left ventricular pacing is associated with significant reduction in heart failure or death in CRT-D patients with LBBB.
abstract: There are limited data on the significance of left ventricular (LV) lead pacing polarity to predict clinical outcomes.
  
  
  
  We aimed to determine the association between the LV lead pacing polarity for heart failure (HF) or death and ventricular tachyarrhythmias (VTA) in patients enrolled in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy), receiving a cardiac resynchronization therapy device with implanted cardioverter-defibrillator (CRT-D).
  
  
  
  We retrospectively analyzed LV pacing polarity. Patients with LV bipolar leads paced between LV ring and LV tip were identified as True Bipolar, while those with LV bipolar leads paced between LV tip or LV ring and right ventricular coil or unipolar leads were identified as Unipolar/Extended Bipolar. Kaplan-Meier survival analyses and multivariate Cox proportional hazards regression models were used.
  
  
  
  Of the 969 patients, 421 had True Bipolar pacing while the remainder (n = 548) had Unipolar/Extended Bipolar pacing. Among patients with left bundle branch block (LBBB), True Bipolar pacing was associated with lower cumulative incidence of death (P = .022) and HF/death (P = .046) compared to those with Unipolar/Extended Bipolar LV pacing. After adjustment for clinical covariates, bipolar LV pacing in LBBB patients was associated with 54% lower risk for death (HR: 0.46; 95% CI: 0.24-0.88; P = .020) and 32% lower risk for HF/death (HR: 0.68; 95% CI: 0.46-1.00; P = .048) compared to Unipolar/Extended Bipolar LV pacing, but not in those with non-LBBB. No association was seen with risk of ventricular tachyarrhythmia.
  
  
  
  True Bipolar LV pacing configuration is associated with a significantly lower risk of HF/death and all-cause mortality in CRT-D patients with LBBB.
authors.affiliation: Stanford University, Stanford, California.
authors.forename: Sina
authors.initials: S
authors.lastname: Jamé
authors.affiliation: University of Rochester Medical Center, Rochester, New York. Electronic address: valentina.kutyifa@heart.rochester.edu.
authors.forename: Valentina
authors.initials: V
authors.lastname: Kutyifa
authors.affiliation: University of Rochester Medical Center, Rochester, New York.
authors.forename: Mehmet K
authors.initials: MK
authors.lastname: Aktas
authors.affiliation: University of Rochester Medical Center, Rochester, New York.
authors.forename: Scott
authors.initials: S
authors.lastname: McNitt
authors.affiliation: University of Rochester Medical Center, Rochester, New York.
authors.forename: Bronislava
authors.initials: B
authors.lastname: Polonsky
authors.affiliation: Stanford University, Stanford, California.
authors.forename: Amin
authors.initials: A
authors.lastname: Al-Ahmad
authors.affiliation: University of Rochester Medical Center, Rochester, New York.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Zareba
authors.affiliation: University of Rochester Medical Center, Rochester, New York.
authors.forename: Arthur
authors.initials: A
authors.lastname: Moss
authors.affiliation: Stanford University, Stanford, California.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Wang
mesh_terms: D000368:Aged; D002037:Bundle-Branch Block / Q000175:diagnosis / Q000628:therapy; D058406:Cardiac Resynchronization Therapy / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D058409:Cardiac Resynchronization Therapy Devices / Q000706:statistics & numerical data; D017147:Defibrillators, Implantable / Q000706:statistics & numerical data; D004452:Echocardiography / Q000379:methods; D004554:Electric Countershock / Q000009:adverse effects / Q000379:methods; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care; D012720:Severity of Illness Index; D016019:Survival Analysis
keywords: Biventricular pacing; Cardiac resynchronization; Death; Heart failure; Pacig polarity