title: [IgG4-related sialodacryoadenitis and chronic rhinosinusitis: a clinicopathologic analysis of 13 cases].
abstract: OBJECTIVE
  To study the clinicopathologic characteristics of IgG4-related sialodacryoadenitis and chronic rhinosinusitis (CRS).
  
  
  METHODS
  A total of 13 patients (patient group) were evaluated clinically and biopsy specimens from the lacrimal/salivary glands (n=12) and nasal mucosa (n=8) were reviewed and immunohistochemistry was performed to assess IgG-and IgG4-positive cells. Similarly, nine patients with IgG4-related sialodacryoadenitis without CRS and 10 patients with common CRS were included as controls.
  
  
  RESULTS
  There were 8 male patients and 5 female patients. The age of patients ranged from 32 to 71 years (mean 50.2 years). The patient group had higher serum IgG4 concentration than that of the control group (P<0.05). Lymphoplasmacytic infiltration, lymphoid follicle formation and sclerosis were prominent in lacrimal/salivary glands in both groups; however the magnitude of IgG4-positive plasmacytic infiltration in the patient group was significantly higher than that of the control group (P<0.05). Similarly, evaluation of nasal mucosa revealed greater lymphocytic and plasmacytic infiltration, and lymphoid follicle formation, together with significantly higher amount of IgG4-positive plasma cell infiltration in the patient group compared to the common CRS group (P<0.05).
  
  
  CONCLUSIONS
  IgG4-related disease (IgG4-RD) simultaneously involving lacrimal/salivary glands and nasal cavity/paranasal sinuses is rare and characterized by a combination of IgG4-positive plasma cell infiltration involving lacrimal/salivary glands and nasal mucosa along with an increased serum level of IgG4. As a systemic disease, early and accurate diagnosis is therefore of great importance, and unnecessary surgery should be avoided.
authors.affiliation: Department of Pathology, Beijing Tongren Hospital, Capital Medical University; the Key Laboratory of Head and Neck Molecular Pathological Diagnosis, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Yingshi
authors.initials: Y
authors.lastname: Piao
authors.forename: Wenling
authors.initials: W
authors.lastname: Yu
authors.forename: Chunyan
authors.initials: C
authors.lastname: He
authors.forename: Changli
authors.initials: C
authors.lastname: Yue
authors.forename: Honggang
authors.initials: H
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007150:Immunohistochemistry; D007765:Lacrimal Apparatus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology; D010256:Paranasal Sinuses / Q000473:pathology; D012220:Rhinitis / Q000175:diagnosis* / Q000276:immunology; D012469:Salivary Glands / Q000473:pathology; D012793:Sialadenitis / Q000175:diagnosis* / Q000276:immunology; D012852:Sinusitis / Q000175:diagnosis* / Q000276:immunology
chemical_list: D007074:Immunoglobulin G