title: Acute Myeloid Leukemia: A Concise Review.
abstract: Acute myeloid leukemia (AML) is a heterogeneous clonal disorder characterized by immature myeloid cell proliferation and bone marrow failure. Cytogenetics and mutation testing remain a critical prognostic tool for post induction treatment. Despite rapid advances in the field including new drug targets and increased understanding of the biology, AML treatment remains unchanged for the past three decades with the majority of patients eventually relapsing and dying of the disease. Allogenic transplant remains the best chance for cure for patients with intermediate or high risk disease. In this review, we discuss the landmark genetic studies that have improved outcome prediction and novel therapies.
authors.affiliation: Medical Oncology/Hematology, Department of Internal Medicine, Starling-Loving Hall, Room M365, 320 W. 10th Ave., Columbus, OH 43210, USA. Jennifer.saultz@osumc.edu.
authors.forename: Jennifer N
authors.initials: JN
authors.lastname: Saultz
authors.affiliation: Division of Hematology, Department of Internal Medicine, 460 W 12th Ave, Columbus, OH 43210, USA. ramiro.garzon@osumc.edu.
authors.forename: Ramiro
authors.initials: R
authors.lastname: Garzon
keywords: AML; leukemia; review