title: Does Inflammation Mediate the Association Between Obesity and Insulin Resistance?
abstract: In adult obesity, low-grade systemic inflammation is considered an important step in the pathogenesis of insulin resistance (IR). The association between obesity and inflammation is less well established in adolescents. Here, we ascertain the importance of inflammation in IR among obese adolescents by utilizing either random forest (RF) classification or mediation analysis approaches. The inflammation balance score, composed of eight pro- and anti-inflammatory makers, as well as most of the individual inflammatory markers differed significantly between lean and overweight/obese. In contrast, adiponectin was the only individual marker selected as a predictor of IR by RF, and the balance score only revealed a medium-to-low importance score. Neither adiponectin nor the inflammation balance score was found to mediate the relationship between obesity and IR. These findings do not support the premise that low-grade systemic inflammation is a key for the expression of IR in the human. Prospective longitudinal studies should confirm these findings.
authors.affiliation: Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
authors.forename: Razieh
authors.initials: R
authors.lastname: Adabimohazab
authors.affiliation: Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Garfinkel
authors.affiliation: Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
authors.forename: Emily C
authors.initials: EC
authors.lastname: Milam
authors.affiliation: Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
authors.forename: Olivia
authors.initials: O
authors.lastname: Frosch
authors.affiliation: Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Mangone
authors.affiliation: Department of Psychiatry, New York University School of Medicine, New York, NY, USA. antonio.convit@med.nyu.edu.|Department of Medicine, New York University School of Medicine, New York, NY, USA. antonio.convit@med.nyu.edu.|Department of Radiology, New York University School of Medicine, New York, NY, USA. antonio.convit@med.nyu.edu.|Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA. antonio.convit@med.nyu.edu.|Brain, Obesity, and Diabetes Laboratory (BODyLab), New York University School of Medicine, 145 East 32nd Street, 8th Floor, New York, NY, 10016, USA. antonio.convit@med.nyu.edu.
authors.forename: Antonio
authors.initials: A
authors.lastname: Convit
mesh_terms: D052242:Adiponectin / Q000032:analysis; D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D007249:Inflammation / Q000150:complications*; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications*; D011237:Predictive Value of Tests
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers
keywords: inflammation; inflammation balance score; insulin resistance; obesity; random forest