title: Embryology of the Absent Vas Supported by 2 Cases of Congenital Unilateral Absence of Vas With Varied Associations.
abstract: Congenital absence of the vas occurs in up to 1% of men. Congenital unilateral absence of the vas deferens can be related to cystic fibrosis transmembrane conductance regulator mutations or in 79% of cases, renal agenesis. We present a case of each, diagnosed in children at operation for elective inguinal hernia repairs. One patient had associated ipsilateral renal agenesis with a normal cystic fibrosis screen. The other patient had an ipsilateral pelvic kidney and a mutation detected on cystic fibrosis screening. Current understanding of the embryology of the relationship between these defects would seem to be supported by our cases.
authors.affiliation: Department of Paediatric Urology, Nottingham Children's Hospital, Queen's Medical Centre, Nottingham, UK.
authors.forename: Gregory
authors.initials: G
authors.lastname: Shepherd
authors.affiliation: Department of Paediatric Urology, The Children's Hospital, Leicester Royal Infirmary, Leicester, UK.
authors.forename: Ashok
authors.initials: A
authors.lastname: Rajimwale
keywords: Absent vas; Cystic fibrosis; Embryology; Renal agenesis