title: Impact of Cold Ischemia Time on Outcomes of Liver Transplantation: A Single Center Experience.
abstract: BACKGROUND
  Significant geographic disparities exist in access to liver transplantation and consequently the current liver allocation system is being challenged. We sought to describe our unique experience with using organs with long cold ischemia times from the largest donation service area.
  
  
  METHODS
  From 2009-2014 we performed 350 liver transplants. 167 (48%) had a cold ischemia time <8 hours, 134 (38%) between 8 and 12 hours, and 49 (14%) greater than 12 hours.
  
  
  RESULTS
  Early allograft dysfunction was observed more commonly with increasing cold ischemia times. 53% of the recipients in the >12 h group had early allograft dysfunction compared to 28% in the 8-12 h group, and 18% in the <8 h group (P<0.001). We found no correlation between early allograft dysfunction and allograft or patient survival. One-year liver allograft survival was 92%, 94%, 87%, three-year graft survival was 82%, 89%, and 87%, and five-year graft survival was 82%, 89%, and 79% in the <8 h, 8-12 h, and >12 h cold ischemia time groups, respectively. One-year patient survival was 95%, 94%, and 92% and five-year patient survival was 90%, 89%, and 83% in the <8 h, 8-12 h, and >12 h cold ischemia time groups, respectively. Both unadjusted and multivariate Cox regression analyses indicated no statistically significant associations between cold ischemia time and graft or patient survival.
  
  
  CONCLUSIONS
  In conclusion, the prolonged cold ischemia time led to early allograft dysfunction but did not have a deleterious association with graft or patient survival.
authors.affiliation: Department of Surgery, Division of Transplantation, University of Washington, Seattle, WA, USA.
authors.forename: Lena
authors.initials: L
authors.lastname: Sibulesky
authors.affiliation: Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington, Seattle, WA, USA.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington, Seattle, WA, USA.
authors.forename: Ryan N
authors.initials: RN
authors.lastname: Hansen
authors.affiliation: Department of Surgery, Division of Transplantation, University of Washington, Seattle, WA, USA.
authors.forename: Andre A S
authors.initials: AA
authors.lastname: Dick
authors.affiliation: Department of Surgery, Division of Transplantation, University of Washington, Seattle, WA, USA.
authors.forename: Martin I
authors.initials: MI
authors.lastname: Montenovo
authors.affiliation: Department of Surgery, Division of Transplantation, University of Washington, Seattle, WA, USA.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Rayhill
authors.affiliation: Department of Surgery, Division of Transplantation, University of Washington, Seattle, WA, USA.
authors.forename: Ramasamy
authors.initials: R
authors.lastname: Bakthavatsalam
authors.affiliation: Department of Surgery, Division of Transplantation, University of Washington, Seattle, WA, USA.
authors.forename: Jorge D
authors.initials: JD
authors.lastname: Reyes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050377:Cold Ischemia / Q000706:statistics & numerical data*; D051799:Delayed Graft Function / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009926:Organ Preservation / Q000379:methods* / Q000706:statistics & numerical data; D017063:Outcome Assessment, Health Care; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors; D014184:Transplantation, Homologous / Q000379:methods / Q000401:mortality; D014861:Washington; D055815:Young Adult