title: Relationship between HLA-DRB1 allele polymorphisms and familial aggregations of hepatocellular carcinoma.
abstract: OBJECTIVE
  We explored the relationship between HLA-DRB1 allele polymorphisms and familial aggregation of hepatocellular carcinoma (fhcc).
  
  
  METHODS
  Polymerase chain reaction sequence-specific primers were used to determine HLA-DRB1 genotypes for 130 members of families with 2 or more liver cancer patients and for 130 members of families without any diagnosed cancers. The genotype profiles were then compared to explore the relationship between HLA-DRB1 gene polymorphism and fhcc.
  
  
  RESULTS
  Of 11 selected alleles, the frequencies of DRB1*11 and DRB1*12 were significantly lower in the fhcc group than in no-cancer group (p < 0.05; odds ratio: 0.286; 95% confidence interval: 0.091 to 0.901; and odds ratio: 0.493; 95% confidence interval: 0.292 to 0.893). Differences in the frequencies of the other 9 alleles were not statistically significant in the two groups (p > 0.05).
  
  
  CONCLUSIONS
  Our research suggests that if genetic factors play a role in fhcc, the deficiency in the DRB1*11 and DRB1*12 alleles might be the risk factor at work in Guangxi Zhuang Autonomous Region, P.R.C.
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, P.R.C.
authors.forename: S
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, P.R.C.
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, P.R.C.
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, P.R.C.
authors.forename: Y
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, P.R.C.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, P.R.C.
authors.forename: Q
authors.initials: Q
authors.lastname: Ning
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, P.R.C.
authors.forename: D
authors.initials: D
authors.lastname: Hu
keywords: HLA-DRB1 alleles; familial aggregation; hepatocellular carcinoma; pcr-ssp; polymorphisms