title: PROMIS Fatigue Item Bank had Clinical Validity across Diverse Chronic Conditions.
abstract: To evaluate the comparability and responsiveness of Patient-Reported Outcomes Measurement Information System (PROMIS) fatigue item bank across six chronic conditions.
  
  
  
  Individuals (n = 1,430) with chronic obstructive pulmonary disease (n = 125), chronic heart failure (n = 60), chronic back pain (n = 218), major depressive disorder (n = 196), rheumatoid arthritis (n = 521), and cancer (n = 310) completed assessments from the PROMIS fatigue item bank at baseline and a clinically relevant follow-up. The cancer and arthritis samples were followed in observational studies; the other four groups were enrolled immediately before a planned clinical intervention. All participants completed global ratings of change at follow-up. Linear mixed-effects models and standardized response means were estimated to examine clinical validity and responsiveness to change.
  
  
  
  All patient groups reported more fatigue than the general population (range = 0.2-1.29 standard deviation worse). The four clinical groups with pretreatment baseline data experienced significant improvement in fatigue at follow-up (effect size range = 0.25-0.91). Individuals reporting better overall health usually experienced larger fatigue changes than those reporting worse overall health.
  
  
  
  The results support the PROMIS fatigue measures's responsiveness to change in six different chronic conditions. In addition, these results support the ability of the PROMIS fatigue measures to compare differences in fatigue across a range of chronic conditions, thereby enabling comparative effectiveness research.
authors.affiliation: Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 633 N. St. Clair, 19th Floor, Chicago, IL, USA. Electronic address: d-cella@northwestern.edu.
authors.forename: David
authors.initials: D
authors.lastname: Cella
authors.affiliation: Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 633 N. St. Clair, 19th Floor, Chicago, IL, USA.
authors.forename: Jin-Shei
authors.initials: JS
authors.lastname: Lai
authors.affiliation: Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 633 N. St. Clair, 19th Floor, Chicago, IL, USA.
authors.forename: Sally E
authors.initials: SE
authors.lastname: Jensen
authors.affiliation: Department of Neurology, Health Science Center T12-045, ​Stony Brook University, Stony Brook, NY 11794-8121, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Christodoulou
authors.affiliation: University of Southern California, USC Dornsife Center for Self-Report Science, 635 Downey Way, ​Los Angeles, CA 90089-3332, USA.
authors.forename: Doerte U
authors.initials: DU
authors.lastname: Junghaenel
authors.affiliation: Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 1101D McGavran-Greenberg Hall, CB #7411, Chapel Hill, NC 27599-7411, USA.
authors.forename: Bryce B
authors.initials: BB
authors.lastname: Reeve
authors.affiliation: University of Southern California, USC Dornsife Center for Self-Report Science, 635 Downey Way, ​Los Angeles, CA 90089-3332, USA.
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Stone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease / Q000453:epidemiology*; D015897:Comorbidity; D005221:Fatigue / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D015203:Reproducibility of Results; D057566:Self Report; D011795:Surveys and Questionnaires / Q000592:standards*; D055815:Young Adult
keywords: Chronic conditions; Fatigue; Item bank; PROMIS; Patient-reported outcomes; Responsiveness