title: Maternal oral administration of osteocalcin protects offspring from metabolic impairment in adulthood.
abstract: OBJECTIVE
  Maternal diet during pregnancy has been found to influence the health of offspring. However, strategies for modulation of maternal energy metabolism without an adverse effect on the fetus have remained limited. It was recently shown that oral administration of uncarboxylated osteocalcin (GluOC) improves metabolic status in adult female mice. Whether maternal GluOC administration during gestation might improve the metabolic status of offspring was investigated.
  
  
  METHODS
  Female C57BL/6 mice were fed a normal diet (ND) or high-fat, high-sucrose diet (HFS) and were given saline or GluOC by oral administration during pregnancy. The resulting offspring were in turn assigned to ND- or HFS-fed groups immediately after weaning, and their body weight, glucose metabolism, serum lipid parameters, and level of adipose tissue inflammation were subsequently assessed.
  
  
  RESULTS
  Maternal HFS feeding during gestation had adverse effects on glucose and lipid parameters, body weight, and adipose tissue inflammation in female offspring fed the same diet, and these effects were attenuated by maternal oral GluOC administration.
  
  
  CONCLUSIONS
  Maternal oral administration of GluOC protects HFS-fed female offspring from metabolic disorders induced by maternal obesity.
authors.affiliation: Laboratory of Molecular and Cellular Biochemistry, Kyushu University, Japan.|Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Fukuoka, Japan.
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Kawakubo-Yasukochi
authors.affiliation: Laboratory of Molecular and Cellular Biochemistry, Kyushu University, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kondo
authors.affiliation: Laboratory of Molecular and Cellular Biochemistry, Kyushu University, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Mizokami
authors.affiliation: Laboratory of Molecular and Cellular Biochemistry, Kyushu University, Japan.|Section of Oral and Maxillofacial Oncology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: Laboratory of Molecular and Cellular Biochemistry, Kyushu University, Japan.
authors.forename: Sakura
authors.initials: S
authors.lastname: Chishaki
authors.affiliation: Section of Oral and Maxillofacial Oncology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Division of Applied Pharmacology, Kyushu Dental University, Kitakyushu, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeuchi
authors.affiliation: Laboratory of Molecular and Cellular Biochemistry, Kyushu University, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Hirata
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005947:Glucose / Q000378:metabolism; D008055:Lipids / Q000097:blood; D039382:Maternal Nutritional Physiological Phenomena; D008659:Metabolic Diseases / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000378:metabolism*; D015675:Osteocalcin / Q000008:administration & dosage* / Q000378:metabolism; D011247:Pregnancy; D014886:Weaning
chemical_list: D008055:Lipids; D015675:Osteocalcin; D005947:Glucose