title: A case of unusual histology of infantile lipoblastoma confirmed by PLAG1 rearrangement.
abstract: Lipoblastoma, a relatively rare benign adipose neoplasm, predominantly affects children younger than 3 years of age. We herein report the case of a 7-month-old girl with an unusual myxomatous histology of lipoblastoma. A rapidly growing mass was detected in the subcutaneous area of the left buttock. Histologically, the tumor consisted of abundant myxoid stroma exhibiting cellular atypia and a high mitotic activity. Although the histological findings were unusual, the tumor was diagnosed as a lipoblastoma according to both PLAG1 immunohistochemistry and the presence of PLAG1 rearrangement on fluorescence in situ hybridization.
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. tshinkai@md.tsukuba.ac.jp.
authors.forename: Toko
authors.initials: T
authors.lastname: Shinkai
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. kmasu@md.tsukuba.ac.
authors.forename: Kouji
authors.initials: K
authors.lastname: Masumoto
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. kentarock1011@mac.com.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ono
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. eyano-tuk@umin.ac.jp.
authors.forename: Eri
authors.initials: E
authors.lastname: Yano
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. ckobayashi@md.tsukuba.ac.jp.
authors.forename: Chie
authors.initials: C
authors.lastname: Kobayashi
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. tksfksm@md.tsukuba.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukushima
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. rsuma@md.tsukuba.ac.jp.
authors.forename: Ryo
authors.initials: R
authors.lastname: Sumazaki
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. kaishis@md.tsukuba.ac.jp.
authors.forename: Kaishi
authors.initials: K
authors.lastname: Satomi
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. nmasayuk@md.tsukuba.ac.jp.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Noguchi
keywords: Fluorescence in situ hybridization (FISH); Immunohistochemistry (IHC); Lipoblastoma; PLAG1