title: [Effect of Zishen Huoxue Recipe on Pathomorphology in Coronary Heart Disease Rats with Shen Deficiency Blood Stasis Syndrome].
abstract: OBJECTIVE
  To observe the effect of Zishen Huoxue Recipe (ZHR) on pathomorphology in coronary heart disease (CHD) rats with Shen deficiency blood stasis syndrome (SDBSS).
  
  
  METHODS
  Totally 60 healthy Wistar rats were divided into the blank control group, the model group, high, middle, and low dose ZHR groups according to random digit table, 12 in each group. Myocardial ischemia SDBSS rat model was prepared by ligating the left anterior descending coronary artery and injecting hydrocortisone. ZHR physic liquor was administered to rats in high, middle, and low dose ZHR groups at the daily dose of 21.6, 10.8, 5.4 g/kg by gastrogavage for 7 successive days, equal volume of pure water was administered to rats in the blank control group and the model group by gastrogavage for 7 successive days. Rat heart was collected for pathomorphological observation under light microscope.
  
  
  RESULTS
  In the model group the heart muscle fiber was swollen and deformed with widened space, loose and dropsy tissues. Blood vessels in myocardial mesenchymal were dilated, infiltrated with more inflammatory cells. Myocardial cells were markedly swollen, degenerated, or necrotic, with caryolysis or disappearance of partial nuclear. A large amount of collagen fibrous tissue became hyperplasia. Endocardial blood vessels were swollen and degenerated with infiltration of few inflammatory cells. Epicardium tissue and structure were destroyed and got hyperplasia. Swollen, degenerated, or necrotic vessels could be seen, with infiltration of more inflammatory cells and collagen deposition. Pathomorphological injuries were alleviated in each ZHR group. The higher ZHR concentration, the milder the injury degree of myocardial tissue, the more limited range of damage.
  
  
  CONCLUSIONS
  ZHR could attenuate pathomorphological injuries of myocardial ischemia rats with SDBSS and regulate myocardial function, thus improving myocardial ischemia in CHD rats with SDBSS.
authors.forename: Sheng-fang
authors.initials: SF
authors.lastname: Zhou
authors.forename: Ru-xiu
authors.initials: RX
authors.lastname: Liu
authors.forename: He-wei
authors.initials: HW
authors.lastname: Luo
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xuan-ke
authors.initials: XK
authors.lastname: Guan
authors.forename: Lin-lin
authors.initials: LL
authors.lastname: Yin
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Dong-peng
authors.initials: DP
authors.lastname: Hu
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D008516:Medicine, Chinese Traditional; D017202:Myocardial Ischemia; D009206:Myocardium; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal