title: Role of multifaceted regulators in cancer glucose metabolism and their clinical significance.
abstract: Aberrant glucose metabolism, "aerobic glycolysis" or "Warburg effect", is a hallmark of human cancers. There is a cluster of "multifaceted regulators", which plays a pivotal role in the regulation of glucose metabolism. They can not only modulate the activities of specific enzymes, but also act as transcriptional activators to regulate the expression of metabolism related genes. Additionally, they can crosstalk with other key factors involved in glucose metabolism and work together to initiate multiple oncogenic processes. These "multifaceted regulators", especially p53, HIF-1, TIGAR and microRNA, will be focused in this review. And we will comprehensively illustrate their regulatory effects on cancer glucose metabolism, and further elaborate on their clinical significance. In-depth elucidation the role of "multifaceted regulators" in cancer glucose metabolism will provide us novel insights in cancer research field and offer promising therapeutic targets for anti-cancer therapies.
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.|Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China.|Department of Pathology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.|Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Luqing
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Yitao
authors.initials: Y
authors.lastname: Mao
authors.affiliation: School of Information Sceince and Engineering, Central South University, Changsha, Hunan, China.
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Cancer Research Institute, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.|Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
mesh_terms: D051017:Apoptosis Regulatory Proteins; D015972:Gene Expression Regulation, Neoplastic; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis / Q000235:genetics*; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D010744:Phosphoric Monoester Hydrolases; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; D051793:Hypoxia-Inducible Factor 1; D047908:Intracellular Signaling Peptides and Proteins; D035683:MicroRNAs; D016159:Tumor Suppressor Protein p53; D010744:Phosphoric Monoester Hydrolases; C512708:TIGAR protein, human; D005947:Glucose
keywords: HIF-1; TIGAR; glucose metabolism; multifaceted regulators; p53