title: Occult recurrence of monomorphic epitheliotropic intestinal T-cell lymphoma and the role of MATK gene expression in diagnosis.
abstract: Monomorphic epitheliotropic intestinal T-cell lymphomas (MEITL), formerly Type II enteropathy-associated T-cell lymphomas (EATL), are rare peripheral T-cell lymphomas. They are associated with poor survival outcomes, in part because of their late diagnosis. Although MEITLs may be reliably diagnosed based on histological and immunophenotypic findings, overlaps with other NK/T and T-cell lymphomas may confound the diagnosis. The distinctive high-level nuclear staining of the novel marker Megakaryocyte-associated tyrosine kinase (MATK) in MEITLs is an invaluable tool in distinguishing MEITL from classical EATL and other NK/T or T-cell lymphomas. 18-Fluorine-2-fluorodeoxyglucose positron emission tomography (18F-FDG PET) has been shown to be a useful tool in the staging and follow-up of aggressive lymphomas. Herein, we describe an unusual case of occult hepatic recurrence of MEITL that was non-avid on18F-FDG PET, in which diagnosis was confirmed based on the expression of MATK in tumour cells. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Haematology, Singapore General Hospital, Singapore.
authors.forename: Yunxin
authors.identifier: http://orcid.org/0000-0001-9039-3474
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pathology, Singapore General Hospital, Singapore.
authors.forename: Soo-Yong
authors.initials: SY
authors.lastname: Tan
authors.affiliation: Department of Pathology, National University Health System, Singapore.
authors.forename: Bengt Fredrik
authors.initials: BF
authors.lastname: Petersson
authors.affiliation: Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.
authors.forename: Yiu Ming
authors.initials: YM
authors.lastname: Khor
authors.affiliation: Department of Haematology, Singapore General Hospital, Singapore.
authors.forename: Sathish Kumar
authors.initials: SK
authors.lastname: Gopalakrishnan
authors.affiliation: Department of Haematology, Singapore General Hospital, Raffles Cancer Centre, Raffles Hospital, Singapore.
authors.forename: Daryl
authors.initials: D
authors.lastname: Tan
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000235:genetics*; D012008:Recurrence
chemical_list: D014408:Biomarkers, Tumor; C085377:MATK protein, human; D016392:Proto-Oncogene Proteins pp60(c-src)
keywords: MATK; MEITL