title: Management strategies in malignant glaucoma secondary to antiglaucoma surgery.
abstract: OBJECTIVE
  To assess the outcomes of various interventions for malignant glaucoma (MG).
  
  
  METHODS
  A retrospective, comparative analysis of case series were performed on 38 eyes of 35 MG patients treated in Aier Eye Hospital of Wuhan between Jan. 2009 and Dec. 2012. Numerous treatments were administered including medical therapy, neodymium: yttrium- aluminium-garnet (Nd:YAG) laser posterior capsulotomy and hyaloidotomy as well as 3 surgical options. The characteristic, treatment option and outcome of MG in every individual patient were reviewed and analyzed among all patients who were followed up for an average of 27.1±9.1mo.
  
  
  RESULTS
  Four eyes of 3 patients achieved complete resolution with medical therapy. Nd:YAG laser posterior capsulotomy and hyaloidotomy were performed on 2 eyes, both of which achieved resolution after initial intervention. Thirty-two eyes were given surgical treatments with anterior vitrectomy- reformation of anterior chamber in 13 eyes, phacoemulsification- intraocular lens implantation in 10 eyes and phacoemulsification- intraocular lens implantation- anterior vitrectomy in 9 eyes. Resolution of MG was seen in almost all patients. The mean intraocular pressure decreased from 41.87±9.44 mm Hg at presentation to 15.84±3.73 mm Hg at the last visit. The mean anterior chamber depth improved from 0.28±0.27 mm to 2.28±0.19 mm. Twenty eyes with preoperative visual acuity better than counting figure/ 50 cm had various visual improvements. Complications occurred in 3 eyes of 3 patients including bleeding at the entry site of vitrectomy into vitreous cavity, corneal endothelial decompensation and allergic to atropine respectively.
  
  
  CONCLUSIONS
  MG occurs as a result of multiple mechanisms involved simultaneously or sequentially.Medical therapy is advocated as the initial treatment, laser therapy is beneficial in pseudophakic eyes, and different surgical regimen is recommended based on different pathogenesis of MG when non-response occurs to nonsurgical management. MG can be managed successfully by appropriate and timely interventions with good visual outcome.
authors.affiliation: Aier Eye Hospital of Wuhan, Wuhan 430063, Hubei Province,China.
authors.forename: Zuo-Hong
authors.initials: ZH
authors.lastname: Wu
authors.affiliation: Aier Eye Hospital of Wuhan, Wuhan 430063, Hubei Province,China.
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Aier Eye Hospital of Changsha, Changsha 410015, Hunan Province, China; Wilmer Eye Institute, Johns Hopkins University, Baltimore 21231, MD, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
keywords: laser therapy; malignant glaucoma; medical therapy; pathogenesis; surgical interventions