title: The relationship between microvasculature in white matter hyperintensities and cognitive function.
abstract: White matter hyperintensities (WMHs) are associated with cognitive decline, but less is known about pathophysiology of cognitive decline in patients with WMHs. We investigated microvasculature and microstructure in WMHs using intravoxel incoherent motion (IVIM) and their associations with cognitive function. Thirty-two subjects with WMHs were enrolled in our study. Fast diffusion coefficient (D*), perfusion fraction (f) and slow diffusion coefficient (D) from IVIM model were compared between regions of WMHs (periventricular WMHs, PWMHs and deep WMHs, DWMHs) and surrounding normal white matter. Multivariate linear model was used to determine the independent factors associated with cognitive function assessed by the Mini Mental State Examination (MMSE) and the standardized coefficient (β) of factors was estimated. D* was significantly lower (4.95 × 10-3mm2/s versus 8.36 × 10-3mm2/s in PWMHs and 5.04 × 10-3mm2/s versus 8.67 × 10-3mm2/s in DWMHs, both P < 0.001), and f (14.64 % versus 12.01 % in PWMHs and 14.26 % versus 11.31 % in DWMHs, both P < 0.001) and D (1.02 × 10-3mm2/s versus 0.73 × 10-3mm2/s in PWMHs and 0.86 × 10-3mm2/s versus 0.70 × 10-3mm2/s in DWMHs, both P < 0.001) were significantly higher in WMHs. Only f in PWMHs was independently associated with MMSE (β = 0.443, P = 0.016). The decreased D* and increased D in WMHs were similar to previous findings. The increased f in PWMHs relating with better cognition provides the pathophysiological basis in understanding cognitive decline in patients with WMHs.
authors.affiliation: Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
authors.forename: Yerfan
authors.initials: Y
authors.lastname: Jiaerken
authors.affiliation: Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
authors.forename: Ruirui
authors.initials: R
authors.lastname: Song
authors.affiliation: Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
authors.forename: Peiyu
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering and Instrument Science, Key Laboratory for Biomedical Engineering of Education Ministry of China, Zhejiang University, Hangzhou, China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Department of Neurology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Department of Neurology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Psychiatry, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
authors.forename: Hualiang
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China. zhangminming@zju.edu.cn.
authors.forename: Minming
authors.identifier: 0000-0003-0145-7558
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001921:Brain / Q000098:blood supply*; D058245:Cognitive Reserve / Q000502:physiology*; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D055806:Microvessels / Q000033:anatomy & histology*; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013647:Task Performance and Analysis; D066127:White Matter / Q000033:anatomy & histology*
keywords: Cerebral small vessel disease; Diffusion; Intravoxel incoherent motion; Magnetic resonance imaging; Perfusion