title: The effects of neuromuscular facilitation techniques on osteoporosis of hemiplegia limbs and serum leptin level in patients or rats with cerebral infarction.
abstract: This study was to investigate the effect of proprioceptive neuromuscular facilitation techniques (NFT) on osteoporosis and serum leptin level in cerebral infarction patients or rats.
  
  
  
  Forty cerebral infarction rats were randomly grouped into control, sham operation, conventional treatment (CT) group and CT+NFT group. Fifty-two stroke patients with hemiplegia were included in this study.
  
  
  
  The bone mineral densities (BMD) of proximal hemiplegia limbs and serum ALP, BALP, BGP, IL-6 and leptin levels were detected using commercial kits.
  
  
  
  In cerebral infarction rats, the BMD, BGP, BALP, ALP and leptin concentrations in the CT+NFT group was higher compared with the control and CT group, while serum IL-6 level was more reduced by CT+NFT than control and CT. In cerebral infarction patients, both CT and CT+NFT increased the BMD, ALP, BGP and leptin levels. In addition, compared with CT, the BMD, ALP, BGP and leptin levels were markedly increased by CT+NFT. C Conclusion: NFC elevated the BMD of hemiplegia limbs, serum ALP, BGP, IL-6 and leptin levels and, thus, alleviated osteoporosis in rats and patients with cerebral infarction.
authors.affiliation: a Department of Neurology.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Si
authors.affiliation: b Department of Emergency Internal Medicine , Qianfoshan Hospital Affiliated to Shandong University , Jinan , Shandong , PR China.
authors.forename: Ke
authors.initials: K
authors.lastname: Hu
authors.affiliation: c Shandong University School of Medicine , Jinan , Shandong , PR China.
authors.forename: Congcong
authors.initials: C
authors.lastname: Wang
authors.affiliation: a Department of Neurology.
authors.forename: Likun
authors.initials: L
authors.lastname: Jia
authors.affiliation: a Department of Neurology.
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: a Department of Neurology.
authors.forename: Aihua
authors.initials: A
authors.lastname: Wang
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D000818:Animals; D015519:Bone Density; D002544:Cerebral Infarction / Q000150:complications / Q000000981:diagnostic imaging; D004195:Disease Models, Animal; D005260:Female; D005500:Follow-Up Studies; D006429:Hemiplegia / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D052580:Muscle Stretching Exercises / Q000379:methods*; D010024:Osteoporosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D051381:Rats; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D020738:Leptin
keywords: Cerebral infarction; bone density; leptin; osteoporosis