title: Effect of Antiglaucoma Medicine on Intraocular Pressure in DBA/2J Mice.
abstract: BACKGROUND
  The DBA/2J mouse strain is known to develop glaucomatous changes. Intraocular pressure (IOP) fluctuations affected by age or antiglaucoma drug administration were compared among three mouse strains, DBA/2J, C57BL/6, and BALB/c.
  
  
  METHODS
  IOP was measured using the TonoLab tonometer under systemic anesthesia. For each mouse strain, the effects of age and topical administration of antiglaucoma medications (timolol maleate, dorzolamide, brimonidine tartrate, and travoprost) were assessed, and results were compared among the three strains.
  
  
  RESULTS
  IOP started to rise in DBA/2J mice at 21 weeks of age. The highest values of IOP were distributed from 18 to 51 mm Hg. Eighty percent of DBA/2J mice showed maximum IOP at either 35 or 46 weeks. IOP of C57BL/6 ranged from 9 to 14 mm Hg as the mice aged. Treatment with any of the antiglaucoma medications resulted in IOP-lowering effects in all three strains. The difference in levels before and after administration ranged from 6 to 10 mm Hg on average in DBA/2J.
  
  
  CONCLUSIONS
  DBA/2J mice are a useful animal model to study the effects of antiglaucoma therapy.
authors.affiliation: Department of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Sawada
authors.forename: Miki
authors.initials: M
authors.lastname: Hiraoka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohguro
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D005901:Glaucoma / Q000188:drug therapy*; D007429:Intraocular Pressure / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D014065:Tonometry, Ocular
chemical_list: D000959:Antihypertensive Agents