title: Hyperlipidemia Is Associated with Chronic Urticaria: A Population-Based Study.
abstract: The etiology of chronic urticaria (CU) is diverse, with chronic infections and inflammation being reported as considerable contributing factors. Although the prevalence of metabolic syndrome was found to be significantly elevated in patients with CU, no one has specifically estimated the effects on CU following hyperlipidemia. This study aimed to examine the association between hyperlipidemia and CU using a population-based dataset in Taiwan. This study included 9798 adults with CU as cases and 9798 sex- and age-matched controls. These patients were examined for whether they had received a prior diagnosis of hyperlipidemia. We used conditional logistic regression analyses to calculate the odds ratio (OR) and its corresponding 95% confidence interval (CI) for having been previously diagnosed with hyperlipidemia between cases and controls. In total, 7066 (36.1%) patients had received a prior diagnosis of hyperlipidemia, including 4287 (43.8%) among CU cases and 2779 (28.4%) among controls. The conditional logistic regression revealed that the OR of prior hyperlipidemia for cases was 1.97 (95% CI: 1.85~2.09) compared to the controls. Furthermore, compared to patients without CU, patients with CU independently experienced a 1.65-fold (95% CI = 1.55~1.76; p<0.001) increased risk of having a prior hyperlipidemia diagnosis, after adjustments were made. We concluded that CU was associated with having received a prior diagnosis of hyperlipidemia.
authors.affiliation: Department of Surgery, Far Eastern Memorial Hospital, Banciao, Taipei, Taiwan.|Graduate Program in Biomedical Informatics, College of Informatics, Yuan-Ze University, Chung-Li, Taiwan.|Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: Shiu-Dong
authors.initials: SD
authors.lastname: Chung
authors.affiliation: Department of Dermatology, Taipei Medical University and Hospital, Taipei, Taiwan.
authors.forename: Kuo-Hsien
authors.initials: KH
authors.lastname: Wang
authors.affiliation: School of Healthcare Administration, Taipei Medical University, Taipei, Taiwan.|Department of Internal Medicine, Cathay General Hospital, Hsinchu Branch, Hsinchu, Taiwan.
authors.forename: Ming-Chieh
authors.initials: MC
authors.lastname: Tsai
authors.affiliation: Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan.|School of Healthcare Administration, Taipei Medical University, Taipei, Taiwan.
authors.forename: Herng-Ching
authors.initials: HC
authors.lastname: Lin
authors.affiliation: Department & Institute of Physiology, National Yang-Ming University, Taipei, Taiwan.|Department of Cosmetic Applications and Management, Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan.|Department of Thoracic Surgery, MacKay Memorial Hospital, Taipei, Taiwan.
authors.forename: Chao-Hung
authors.initials: CH
authors.lastname: Chen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D016208:Databases, Factual; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D013624:Taiwan / Q000453:epidemiology; D014581:Urticaria / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology*