title: Cancer cell associated glycans as targets for immunotherapy.
abstract: Therapeutic anti-glycan antibodies for cancer treatment are limited, in spite of the differential glycophenotype of cancer cells and associated biology. We have generated anti-Le glycan antibodies with clinical potential and multifaceted functionality. Increased understanding of all aspects of glycomic research will ensure the continued development of glycan-targeted immunotherapeutics.
authors.affiliation: Division of Cancer and Stem Cells; School of Medicine; City Hospital Campus; University of Nottingham ; Hucknall Road ; Nottingham, UK.
authors.forename: Mireille
authors.initials: M
authors.lastname: Vankemmelbeke
authors.affiliation: Division of Cancer and Stem Cells; School of Medicine; City Hospital Campus; University of Nottingham ; Hucknall Road ; Nottingham, UK.
authors.forename: Jia Xin
authors.initials: JX
authors.lastname: Chua
authors.affiliation: Division of Cancer and Stem Cells; School of Medicine; City Hospital Campus; University of Nottingham ; Hucknall Road ; Nottingham, UK.
authors.forename: Lindy G
authors.initials: LG
authors.lastname: Durrant
keywords: ADC; glycomics; lewis glycan; programmed cell death; therapeutic antibody