title: Is the use of esomeprazole in gastroesophageal reflux disease a cost-effective option in Poland?
abstract: OBJECTIVE
  To compare the cost-effectiveness of therapy of gastroesophageal reflux disease with esomeprazole and other proton pump inhibitors (PPIs) in Poland.
  
  
  METHODS
  Studies comparing esomeprazole with other PPIs in the treatment of erosive esophagitis, non-erosive reflux disease and gastroesophageal reflux disease maintenance therapy were systematically reviewed. 9 randomized clinical trials were selected, meta-analyses were conducted. Cost data derived from Polish Ministry of Health and Pharmacies in Wroclaw.
  
  
  RESULTS
  In the treatment of erosive esophagitis esomeprazole was significantly more effective than other PPIs. Both for 4- and 8-week therapy respective incremental cost-effectiveness ratio values were acceptably low. Differences in effectiveness of non-erosive reflux disease therapy were not significant. The replacement of pantoprazole 20 mg with more effective esomeprazole 20 mg in the 6-month maintenance therapy was associated with a substantially high incremental cost-effectiveness ratio.
authors.affiliation: Department of Clinical Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Petryszyn
authors.affiliation: Department of Clinical Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Staniak
authors.affiliation: Department of Histology & Embriology, Wroclaw Medical University, Poland.
authors.forename: Jedrzej
authors.initials: J
authors.lastname: Grzegrzolka
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000191:economics / Q000627:therapeutic use; D003362:Cost-Benefit Analysis / Q000706:statistics & numerical data*; D064098:Esomeprazole / Q000191:economics* / Q000627:therapeutic use*; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000191:economics; D006801:Humans; D000077402:Pantoprazole; D011044:Poland; D054328:Proton Pump Inhibitors / Q000191:economics / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D054328:Proton Pump Inhibitors; D000077402:Pantoprazole; D064098:Esomeprazole
keywords: cost effectiveness; esomeprazole; gastroesophageal reflux