title: [Serum homocysteine and metabolic syndrome in middle-aged and elderly men].
abstract: OBJECTIVE
  To investigate the relationship among serum reproductive hormone levels, serum homocysteine (Hcy) levels, metabolic syndrome (MS), and the components of MS in middle-aged and elderly males.
  
  
  METHODS
  Using the cluster and stratified sampling methods and a unified structured questionnaire, we conducted a survey among 948 men aged 40 - 80 years in the rural community, measured their basic physical parameters, and obtained their reproductive hormone levels, serum Hcy concentrations, and metabolism-related indicators. We collected 868 valid questionnaires along with their serum samples, divided the subjects into an MS and a non-MS control group in a 1:1 ratio, and measured their serum Hcy concentrations.
  
  
  RESULTS
  Among the subjects included, 132 were diagnosed with MS. Nonparametric tests showed statistically significant differences between the MS and non-MS groups in the waist circumference (WC), waist-hip ratio (WHR), body mass index (BMI), systolic blood pressure (SBP), and diastolic blood pressure (DBP) (P < 0.05), but not in age (P > 0.05). Significant differences were also observed between the two groups in the levels of serum tT, SHBG, LH, and FTI (P < 0.05) , but not in the concentrations of serum Hcy (P > 0.05). The concentration of serum Hcy exhibited no correlation with BMI, SBP, DBP, FBG, TG, and HDL-C (P > 0.05) and had no influence on MS.
  
  
  CONCLUSIONS
  The concentration of serum Hcy is not significantly correlated with MS, nor with its components. The levels of male serum reproductive hormones are associated both with MS and with its components.
authors.forename: Ming-jia
authors.initials: MJ
authors.lastname: Zhao
authors.forename: Yi-hong
authors.initials: YH
authors.lastname: Yang
authors.forename: Shan-jie
authors.initials: SJ
authors.lastname: Zhou
authors.forename: Dong
authors.initials: D
authors.lastname: Yuan
authors.forename: Wen-hong
authors.initials: WH
authors.lastname: Lu
authors.lastname: Liang Xiao-wei
authors.forename: Bao-long
authors.initials: BL
authors.lastname: Zhang
authors.forename: Yu-dang
authors.initials: YD
authors.lastname: Ji
authors.forename: Can-gang
authors.initials: CG
authors.lastname: Wang
authors.forename: Yi-qun
authors.initials: YQ
authors.lastname: Gu
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis; D008875:Middle Aged; D012098:Reproduction; D012424:Rural Population; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood; D013974:Thyroxine / Q000097:blood; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D012738:Sex Hormone-Binding Globulin; D006710:Homocysteine; D013739:Testosterone; D007986:Luteinizing Hormone; D013974:Thyroxine