title: Mathematical model for calcium-assisted epidermal homeostasis.
abstract: Using a mathematical model of the epidermis, we propose a mechanism of epidermal homeostasis mediated by calcium dynamics. We show that calcium dynamics beneath the stratum corneum can reduce spatio-temporal fluctuations of the layered structure of the epidermis. We also demonstrate that our model can reproduce experimental results that the recovery from a barrier disruption is faster when the disrupted site is exposed to air. In particular, simulation results indicate that the recovery speed depends on the size of barrier disruption.
authors.affiliation: Research Institute for Electronic Science, Hokkaido University, N12W7, Kita-ku, Sapporo 060-0812, Japan; CREST, Japan Science and Technology Agency, Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan. Electronic address: yasuaki.kobayashi@es.hokudai.ac.jp.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Department of Mathematics, Graduate School of Science, Hokkaido University, N12W7, Kita-ku, Sapporo 060-0812, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sawabu
authors.affiliation: Department of Physics, Graduate School of Science, Chiba University, Yayoi-cho 1-33, Chiba 263-8522, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kitahata
authors.affiliation: Shiseido Research Center, Shiseido Co., Ltd., 2-12-1 Fukuura, Kanazawa-ku, Yokohama 236-8643, Japan; CREST, Japan Science and Technology Agency, Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Denda
authors.affiliation: Research Institute for Electronic Science, Hokkaido University, N12W7, Kita-ku, Sapporo 060-0812, Japan; CREST, Japan Science and Technology Agency, Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan; CREST, Japan Science and Technology Agency, Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan. Electronic address: nagayama@es.hokudai.ac.jp.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nagayama
mesh_terms: D000465:Algorithms; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D000078404:Epidermal Cells; D004817:Epidermis / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological
chemical_list: D002118:Calcium
keywords: Dermatology; Dynamical system; Reaction-diffusion system