title: Postradiation angiosarcoma of bladder with extensive osseous metaplasia.
abstract: Angiosarcomas are rare soft tissue neoplasms accounting for <2% of all sarcomas. Rare cases have been reported in other sites like breast, spleen, liver, bone and bladder. This is a case report of an angiosarcoma of the bladder in a 65 year old lady who came with complaints of haematuria. Ultrasonography and computerized tomography revealed a bladder tumour with calcification, which on cystoscopy also showed a calcified mass. The patient had a past history of carcinoma cervix for which she had undergone surgery and radiotherapy, 22 years ago. Biopsy of the bladder mass showed features of a high grade epithelioid sarcoma with extensive osseous metaplasia. On immune stains,the tumour was positive for CD31 and vimentin and negative for cytokeratin, desmin and CD34. Until now, only sixteen cases of angiosarcoma of the bladder have been reported in english literature, of which 6 occurred secondary to radiation. Our case is the first to occur after 22 years of radiotherapy and have extensive osseous metaplasia.
authors.affiliation: Department of Histopathology, Apollo Hospital, Hyderabad, Telangana, India.
authors.forename: Hima Bindu
authors.initials: HB
authors.lastname: Rallabandi
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Swain
authors.forename: Swarnalata
authors.initials: S
authors.lastname: Gowrishankar
authors.forename: Sanjay
authors.initials: S
authors.lastname: Sinha
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D003558:Cystoscopy; D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008679:Metaplasia / Q000473:pathology*; D008853:Microscopy; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D014746:Vimentin