title: [Development of new magistral method for the preparation of artificial tears].
abstract: Nowadays, large part of the population in Hungary is affected by the dry eye disease or symptom. Most of these magistral pharmaceuticals (FoNo VI) compared to the industrial products have disadvantages. They are not compatible with contact lenses, because of the preservatives and after opening they can be used only for seven days. In our experiments we used sodium-perborate as preservative, which could be a solution for the problems mentioned above. Our results indicate that the sodium-perborate sterilized the solution and resists against microbiological contamination. Its preservative effect maintained for more than four weeks. Our further purpose is to develop a new pharmacy drug preparation method to find an effective solution for the microbiological stability-related problems of artificial tears.
authors.forename: Georgina
authors.initials: G
authors.lastname: Kovács
authors.forename: Dávid
authors.initials: D
authors.lastname: Varga
authors.forename: István
authors.initials: I
authors.lastname: Sebe
authors.forename: Mária
authors.initials: M
authors.lastname: Hajdú
authors.forename: Péter
authors.initials: P
authors.lastname: Szabó
authors.forename: Eszter
authors.initials: E
authors.lastname: Ostorházi
authors.forename: István
authors.initials: I
authors.lastname: Antal
mesh_terms: D001881:Borates / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods*; D004340:Drug Contamination / Q000517:prevention & control*; D015352:Dry Eye Syndromes / Q000188:drug therapy; D006801:Humans; D006814:Hungary; D065346:Lubricant Eye Drops / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D001881:Borates; D065346:Lubricant Eye Drops; D011310:Preservatives, Pharmaceutical; C027707:sodium perborate