title: Bilateral Thalamic Glioma: Case Report and Review of the Literature.
abstract: Bilateral thalamic glioma is extremely rare and the incidence cannot be adequately expressed. We present the case of a 72 years old male suffering from the rapid deterioration of cognitive function to moderately severe dementia in a short period of time. Magnetic resonance studies demonstrated a bilateral thalamic glioma with a minimal focal gadolinium uptake in the left thalamus. Biopsy was performed and pathology report was of anaplastic astrocytoma, WHO grade III. Radiotherapy was proposed but was rejected by the patient's relatives. The patient deceased 57 days later. We performed an extensive review of the literature and by updating the previous described series we can state that to the best of our knowledge this is the 60th case described in the literature and the second eldest patient presented. Patients suffering from this disease present a poor prognosis, the longest survival described being of 3 years in patients diagnosed with grade II bilateral thalamic glioma. Adjuvant therapy in form of radiotherapy to the thalami is most commonly used but the benefits are unclear. The natural progression of WHO grade III bilateral thalamic glioma left untreated, as can be seen from our case, has an even poorer outcome.
authors.affiliation: Tirgu Mures Clinical Emergency Hospital, Department of Neurosurgery, Târgu Mureș, Romania.
authors.forename: Adrian
authors.initials: A
authors.lastname: Balasa
authors.forename: Rodica
authors.initials: R
authors.lastname: Balasa
authors.forename: Imre
authors.initials: I
authors.lastname: Egyed-Zsigmond
authors.forename: Rares
authors.initials: R
authors.lastname: Chinezu
mesh_terms: D000368:Aged; D001706:Biopsy; D001932:Brain Neoplasms / Q000473:pathology*; D018450:Disease Progression; D017809:Fatal Outcome; D005910:Glioma / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013786:Thalamic Diseases / Q000473:pathology*