title: Comparison between stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF with GnRH antagonist protocol.
abstract: OBJECTIVE
  Highly purified Human Menopausal Gonadotropins (hp-hMG) and recombinant FSH (rFSH) are widely used in assisted reproductive technology (ART). The aim of this study was to compare ART results of the two preparations in GnRH antagonist cycles.
  
  
  METHODS
  In this retrospective cohort study, IVF antagonist cycles performed from 2011 through 2013 were reviewed. There were 508 antagonist cycles: 320 stimulated with rFSH and 188 with hp-hMG. For every hp-hMG, two rFSH were matched for patient's age and infertility diagnosis. Subgroup analysis of patients younger and older than 35 was done as well.
  
  
  RESULTS
  Both treatments were resulted in comparable pregnancy and live birth rates. However, cumulative pregnancy rates were higher for the rFSH group. In the matching analysis, the rFSH group had more mature oocytes and more embryos while using lower doses of gonadotropins. Pregnancy, cumulative pregnancy rates, and live birth rates were comparable. In the subgroup analysis, young patients in the rFSH group had better cycle outcomes compared with those in the hp-hMG group.
  
  
  CONCLUSIONS
  In antagonist protocol, different gonadotropin products are equally effective. The choice of one or the other should depend on the availability, convenience of use, and cost.
authors.affiliation: a IVF Unit, Department of Obstetrics & Gynecology, Hillel Yaffe Medical Center, Rappaport School of Medicine, Technion, Israel Institute of Technology , Haifa , Hadera , IL , Israel.
authors.forename: Tal
authors.initials: T
authors.lastname: Shavit
authors.affiliation: a IVF Unit, Department of Obstetrics & Gynecology, Hillel Yaffe Medical Center, Rappaport School of Medicine, Technion, Israel Institute of Technology , Haifa , Hadera , IL , Israel.
authors.forename: Einat
authors.initials: E
authors.lastname: Shalom-Paz
authors.affiliation: a IVF Unit, Department of Obstetrics & Gynecology, Hillel Yaffe Medical Center, Rappaport School of Medicine, Technion, Israel Institute of Technology , Haifa , Hadera , IL , Israel.
authors.forename: Nivin
authors.initials: N
authors.lastname: Samara
authors.affiliation: a IVF Unit, Department of Obstetrics & Gynecology, Hillel Yaffe Medical Center, Rappaport School of Medicine, Technion, Israel Institute of Technology , Haifa , Hadera , IL , Israel.
authors.forename: Nardin
authors.initials: N
authors.lastname: Aslih
authors.affiliation: a IVF Unit, Department of Obstetrics & Gynecology, Hillel Yaffe Medical Center, Rappaport School of Medicine, Technion, Israel Institute of Technology , Haifa , Hadera , IL , Israel.
authors.forename: Madiea
authors.initials: M
authors.lastname: Michaeli
authors.affiliation: a IVF Unit, Department of Obstetrics & Gynecology, Hillel Yaffe Medical Center, Rappaport School of Medicine, Technion, Israel Institute of Technology , Haifa , Hadera , IL , Israel.
authors.forename: Adrian
authors.initials: A
authors.lastname: Ellenbogen
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008596:Menotropins / Q000627:therapeutic use*; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D011247:Pregnancy; D018873:Pregnancy Rate; D011994:Recombinant Proteins; D012189:Retrospective Studies
chemical_list: D006727:Hormone Antagonists; D011994:Recombinant Proteins; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins; D005640:Follicle Stimulating Hormone
keywords: Antagonist protocol; assisted reproductive technology; infertility; ovulation induction