title: Serous Retinal Detachment Associated with Dome-Shaped Macula and Staphyloma Edge in Myopic Patients before and after Treatment with Spironolactone.
abstract: Objective. Serous retinal detachment (SRD) is a common anatomical complication associated with dome-shaped macula (DSM) and staphyloma margin in myopic patients. Here we described the anatomical and functional outcomes obtained with the use of oral spironolactone, a mineralocorticoid antagonist, in the management of myopic patients with SRD associated with DSM and staphyloma margin. Methods. We evaluated both eyes of twelve myopic patients with long-standing SRD associated with DSM or staphyloma margin. The patients were treated daily for six months with oral spironolactone 50 mg. Best-corrected visual acuity (BCVA) and central retinal thickness (CRT), determined by optical coherence tomography, were evaluated on the first day and on monthly follow-up visits. Results. Pretreatment BCVA (mean ± standard deviation) was 0.406 ± 0.324 LogMAR, and posttreatment BCVA was 0.421 ± 0.354 LogMAR (P = 0.489). Pretreatment CRT was 323.9 ± 78.6 μm, and after six months of treatment it was significantly lower, 291.2 ± 74.5 μm (P = 0.010). There were no treatment-related complications. Conclusions. We evaluated a novel treatment for SRD associated with DSM and staphyloma margin in myopic patients. After six months of treatment with the mineralocorticoid antagonist spironolactone, the subretinal fluid and CRT were significantly reduced; however, there was no improvement in BCVA.
authors.affiliation: Instituto Oftalmológico Fernández-Vega, 33012 Oviedo, Spain; Instituto Universitario Fernández-Vega, Universidad de Oviedo, Oviedo, Spain.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Fernández-Vega Sanz
authors.affiliation: Instituto Oftalmológico Fernández-Vega, 33012 Oviedo, Spain; Fundación Oftalmológica de Santander (FOSCAL), Floridablanca 681004, Colombia; Universidad Industrial de Santander, Bucaramanga 680002, Colombia.
authors.forename: Carlos Mario
authors.initials: CM
authors.lastname: Rangel
authors.affiliation: Instituto Oftalmológico Fernández-Vega, 33012 Oviedo, Spain; Instituto Universitario Fernández-Vega, Universidad de Oviedo, Oviedo, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Villota Deleu
authors.affiliation: Instituto Oftalmológico Fernández-Vega, 33012 Oviedo, Spain; Instituto Universitario Fernández-Vega, Universidad de Oviedo, Oviedo, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Fernández-Vega Sanz
authors.affiliation: Instituto Universitario Fernández-Vega, Universidad de Oviedo, Oviedo, Spain; Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Ronald Mauricio
authors.initials: RM
authors.lastname: Sánchez-Ávila