title: Proteasome inhibitory, antioxidant, and synergistic antibacterial and anticandidal activity of green biosynthesized magnetic Fe3O4nanoparticles using the aqueous extract of corn (Zea mays L.) ear leaves.
abstract: Herein, Fe3O4nanoparticles synthesized using aqueous extract of corn ear leaves were investigated for proteasome inhibitory activity, antioxidant activity, synergistic antibacterial, and anticandidal potential. The UV-Vis spectrum displayed an absorption band at 355 nm that indicated the formation of nano-sized Fe3O4particles. Vibrating sample magnetometer analysis revealed its superparamagnetic nature. Fe3O4nanoparticles exhibited strong proteasome inhibitory potential and antioxidant activity and exerted strong synergistic antibacterial and anticandidal activity. Its significant proteasome inhibitory potential could be useful in cancer treatment and drug delivery. Furthermore, strong antioxidant, antibacterial, and anticandidal activity make them a promising candidate for biomedical and pharmaceutical applications.
authors.affiliation: a School of Biotechnology , Yeungnam University , Gyeongsan , Gyeongbuk , Republic of Korea.|b Research Institute of Biotechnology & Medical Converged Science , Dongguk University , Ilsandong-gu , Goyang , Republic of Korea.
authors.forename: Jayanta Kumar
authors.initials: JK
authors.lastname: Patra
authors.affiliation: a School of Biotechnology , Yeungnam University , Gyeongsan , Gyeongbuk , Republic of Korea.
authors.forename: Md Sarafat
authors.initials: MS
authors.lastname: Ali
authors.affiliation: c Central Laboratory , Andong National University , Andong , Gyeongbuk , Republic of Korea.
authors.forename: In-Gyung
authors.initials: IG
authors.lastname: Oh
authors.affiliation: a School of Biotechnology , Yeungnam University , Gyeongsan , Gyeongbuk , Republic of Korea.
authors.forename: Kwang-Hyun
authors.initials: KH
authors.lastname: Baek
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D018515:Plant Leaves / Q000737:chemistry*; D061988:Proteasome Inhibitors / Q000737:chemistry / Q000494:pharmacology; D003313:Zea mays / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D000975:Antioxidants; D058185:Magnetite Nanoparticles; D061988:Proteasome Inhibitors
keywords: Antibacterial; Fe3O4 nanoparticles; anticandidal; antioxidant; corn ear leaves; proteasome inhibitory