title: Developmental origins of infant stress reactivity profiles: A multi-system approach.
abstract: This study tested the hypothesis that maternal physiological and psychological variables during pregnancy discriminate between theoretically informed infant stress reactivity profiles.
  
  
  
  The sample comprised 254 women and their infants. Maternal mood, salivary cortisol, respiratory sinus arrhythmia (RSA), and salivary α-amylase (sAA) were assessed at 15 and 32 weeks gestational age. Infant salivary cortisol, RSA, and sAA reactivity were assessed in response to a structured laboratory frustration task at 6 months of age. Infant responses were used to classify them into stress reactivity profiles using three different classification schemes: hypothalamic-pituitary-adrenal (HPA)-axis, autonomic, and multi-system. Discriminant function analyses evaluated the prenatal variables that best discriminated infant reactivity profiles within each classification scheme.
  
  
  
  Maternal stress biomarkers, along with self-reported psychological distress during pregnancy, discriminated between infant stress reactivity profiles.
  
  
  
  These results suggest that maternal psychological and physiological states during pregnancy have broad effects on the development of the infant stress response systems. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58: 578-599, 2016.
authors.affiliation: Department of Psychology, University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Rash
authors.affiliation: Department of Psychology, University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada.
authors.forename: Jenna C
authors.initials: JC
authors.lastname: Thomas
authors.affiliation: Department of Psychology, University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada.
authors.forename: Tavis S
authors.initials: TS
authors.lastname: Campbell
authors.affiliation: Faculty of Nursing and Cumming School of Medicine (Pediatrics and Psychiatry), University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada.|Alberta Children's Hospital Research Institute, University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada.
authors.forename: Nicole
authors.initials: N
authors.lastname: Letourneau
authors.affiliation: Institute for Interdisciplinary Saliva Bioscience Research, Arizona State University, Tempe, AZ, 85287.|Bloomberg School of Public Health and School of Medicine, The John Hopkins University School of Nursing, Baltimore, MD, 21205.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Granger
authors.affiliation: Alberta Children's Hospital Research Institute, University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada.|Department of Pediatrics, Cumming School of Medicine, University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada.
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Giesbrecht
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology; D001341:Autonomic Nervous System / Q000502:physiology*; D015415:Biomarkers; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000502:physiology*; D007223:Infant; D018730:Infant Behavior / Q000145:classification* / Q000502:physiology / Q000523:psychology; D008137:Longitudinal Studies; D010913:Pituitary-Adrenal System / Q000378:metabolism / Q000502:physiology*; D011247:Pregnancy / Q000378:metabolism / Q000502:physiology* / Q000523:psychology; D011248:Pregnancy Complications / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology; D065809:Respiratory Sinus Arrhythmia / Q000502:physiology; D013315:Stress, Psychological / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology; D000516:alpha-Amylases / Q000378:metabolism
chemical_list: D015415:Biomarkers; D000516:alpha-Amylases; D006854:Hydrocortisone
keywords: fetal programming; psychological distress; respiratory sinus arrhythmia; salivary cortisol; salivary α-amylase; stress reactivity