title: Cochlear changes in serous labyrinthitis associated with silent otitis media: A human temporal bone study.
abstract: OBJECTIVE
  To determine histopathological findings in the cochlea of human temporal bones with serous labyrinthitis.
  
  
  METHODS
  We compared human temporal bones with serous labyrinthitis (20 cases) associated with silent otitis media and without serous labyrinthitis (20 cases) to study location of serous labyrinthitis, the degree of endolymphatic hydrops, number of spiral ganglion cells and hair cells, loss of fibrocytes in the spiral ligament, and areas of the spiral ligament and stria vascularis.
  
  
  RESULTS
  The serous labyrinthitis caused significant loss of outer hair cells in the lower basal (P=0.006), upper basal (P=0.005), and lower middle (P=0.011) cochlear turns, and significant increase in the degree of endolymphatic hydrops than the control group (P=0.036). No significant difference was found in the loss of inner hair cells, in the number of spiral ganglion cells and fibrocytes in the spiral ligament, and in areas of the stria vascularis and spiral ligament (P>0.05).
  
  
  CONCLUSIONS
  Serous labyrinthitis resulted in significant loss of outer hair cells and significant increase in the degree of endolymphatic hydrops.
authors.affiliation: Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA; Gebze Fatih State Hospital Division of Otolaryngology, Gebze, Kocaeli, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Kaya
authors.affiliation: Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Tsuprun
authors.affiliation: Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA; Giresun A. Ilhan Ozdemir State Hospital Division of Otolaryngology, Giresun, Turkey.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Hızlı
authors.affiliation: Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Schachern
authors.affiliation: Paparella Ear Head & Neck Institute, Minneapolis, MN, USA.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Paparella
authors.affiliation: Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA. Electronic address: cureo003@umn.edu.
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Cureoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D003051:Cochlea / Q000473:pathology*; D005260:Female; D006198:Hair Cells, Auditory / Q000473:pathology*; D006801:Humans; D007223:Infant; D007762:Labyrinthitis / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010033:Otitis Media / Q000150:complications / Q000175:diagnosis; D013136:Spiral Ganglion / Q000473:pathology*; D013316:Stria Vascularis / Q000473:pathology*; D013701:Temporal Bone / Q000473:pathology*; D055815:Young Adult