title: New potent accelerator of neurite outgrowth from Lawsonia inermis flower under non-fasting condition.
abstract: The methanolic extract of Lawsonia inermis L. (henna) showed accelerative effects on nerve growth factor-induced neurite outgrowth in PC12 cells under non-fasting conditions. To elucidate the active constituents responsible for the neuronal differentiation, we conducted a search of the constituents and examined their accelerative effects on neurite outgrowth in PC12 cells. We isolated a new acetophenone glycoside, inermioside A, which exerted a significant accelerative effect on neurite outgrowth. We also confirmed the activities of nine known compounds, including quercetin and lalioside. In addition, we found that quercetin, one of the active constituents, increased Vav3 mRNA expression.
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.|N. T. H Co., Ltd., 1-8-11 4F Sky-ebisu Bldg., Ebisu, Shibuya-ku, Tokyo, 150-0013, Japan.
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Oda
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan. nakashima@nthhenna.co.jp.|N. T. H Co., Ltd., 1-8-11 4F Sky-ebisu Bldg., Ebisu, Shibuya-ku, Tokyo, 150-0013, Japan. nakashima@nthhenna.co.jp.
authors.forename: Souichi
authors.initials: S
authors.lastname: Nakashima
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Mamiko
authors.initials: M
authors.lastname: Yano
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Akiyama
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Kayo
authors.initials: K
authors.lastname: Imai
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Tomohito
authors.initials: T
authors.lastname: Kimura
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakata
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Tani
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D035264:Flowers / Q000737:chemistry*; D031564:Lawsonia Plant / Q000737:chemistry*; D000071446:Neuronal Outgrowth / Q000502:physiology*; D016716:PC12 Cells; D010936:Plant Extracts / Q000737:chemistry*; D051381:Rats
chemical_list: D010936:Plant Extracts
keywords: Henna; Lawsonia inermis; Neurite outgrowth; PC12; Quercetin; Vav3