title: Modulation of the Translational Landscape During Herpesvirus Infection.
abstract: Herpesviral mRNAs are produced and translated by cellular machinery, rendering them susceptible to the network of regulatory events that impact translation. In response, these viruses have evolved to infiltrate and hijack translational control pathways as well as to integrate specialized host translation strategies into their own repertoire. They are robust systems to dissect mechanisms of mammalian translational regulation and continue to offer insight into cis-acting mRNA features that impact assembly and activity of the translation apparatus. Here, I discuss recent advances revealing the extent to which the three herpesvirus subfamilies regulate both host and viral translation, thereby dramatically impacting the landscape of protein synthesis in infected cells.
authors.affiliation: Department of Plant and Microbial Biology, University of California, Berkeley, California 94720; email: glaunsinger@berkeley.edu.
authors.forename: Britt A
authors.initials: BA
authors.lastname: Glaunsinger
mesh_terms: D000818:Animals; D018178:Flaviviridae Infections / Q000235:genetics* / Q000378:metabolism / Q000821:virology; D015967:Gene Expression Regulation, Viral; D006564:Herpesviridae / Q000235:genetics / Q000502:physiology*; D006801:Humans; D014176:Protein Biosynthesis; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D014764:Viral Proteins
keywords: eIF4F; herpesvirus; protein kinase R; translation; uORF; unfolded protein response