title: Parametric techniques for characterizing myocardial tissue by magnetic resonance imaging (part 1): T1 mapping.
abstract: The development of myocardial fibrosis is a common process in the appearance of ventricular dysfunction in many heart diseases. Magnetic resonance imaging makes it possible to accurately evaluate the structure and function of the heart, and its role in the macroscopic characterization of myocardial fibrosis by late enhancement techniques has been widely validated clinically. Recent studies have demonstrated that T1-mapping techniques can quantify diffuse myocardial fibrosis and the expansion of the myocardial extracellular space in absolute terms. However, further studies are necessary to validate the usefulness of this technique in the early detection of tissue remodeling at a time when implementing early treatment would improve a patient's prognosis. This article reviews the state of the art for T1 mapping of the myocardium, its clinical applications, and its limitations.
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Clínic, Universidad de Barcelona, Barcelona, España. Electronic address: rjperea@clinic.ub.es.
authors.forename: R J
authors.initials: RJ
authors.lastname: Perea Palazón
authors.affiliation: Servicio de Cardiología, Hospital Clínic, Universidad de Barcelona, Barcelona, España.
authors.forename: J T
authors.initials: JT
authors.lastname: Ortiz Pérez
authors.affiliation: Servicio de Cardiología, Hospital Clínic, Universidad de Barcelona, Barcelona, España.
authors.forename: S
authors.initials: S
authors.lastname: Prat González
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Clínic, Universidad de Barcelona, Barcelona, España.
authors.forename: T M
authors.initials: TM
authors.lastname: de Caralt Robira
authors.affiliation: Servicio de Hematología, Hospital Clínic, Universidad de Barcelona, Barcelona, España.
authors.forename: M T
authors.initials: MT
authors.lastname: Cibeira López
authors.affiliation: Servicio de Anatomía Patológica, Hospital Clínic, Universidad de Barcelona, Barcelona, España.
authors.forename: M
authors.initials: M
authors.lastname: Solé Arqués
mesh_terms: D057791:Cardiac Imaging Techniques / Q000379:methods*; D009202:Cardiomyopathies; D005355:Fibrosis / Q000000981:diagnostic imaging; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009206:Myocardium / Q000473:pathology*
keywords: Cardiac magnetic resonance imaging; Diffuse myocardial fibrosis; Disease; Extracellular volume fraction; Fibrosis miocárdica difusa; Fracción de volumen extracelular; Mapas de T1; Miocardio; Myocardium; Patología; Resonancia magnética cardiaca; T1 mapping