title: Antioxidant Activity and α-Glucosidase Inhibitory Activities of the Polycondensate of Catechin with Glyoxylic Acid.
abstract: In order to investigate polymeric flavonoids, the polycondensate of catechin with glyoxylic acid (PCG) was prepared and its chemically antioxidant, cellular antioxidant (CAA) and α-glucosidase inhibitory activities were evaluated. The DPPH and ABTS radical scavenging activities and antiproliferative effect of PCG were lower than those of catechin, while PCG had higher CAA activity than catechin. In addition, PCG had very high α-glucosidase inhibitory activities (IC50 value, 2.59 μg/mL) in comparison to catechin (IC50 value, 239.27 μg/mL). Inhibition kinetics suggested that both PCG and catechin demonstrated a mixture of noncompetitive and anticompetitive inhibition. The enhanced CAA and α-glucosidase inhibitor activities of PCG could be due to catechin polymerization enhancing the binding capacity to the cellular membrane and enzymes.
authors.affiliation: School of Food Science, Henan Institute of Science and Technology, Xinxiang, 453003, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Geng
authors.affiliation: Department of Rehabilitation, The First Affiliated Hospital/School of Clinical Medicine of G.D.P.D, Guangzhou, China.
authors.forename: Sharui
authors.initials: S
authors.lastname: Shan
authors.affiliation: School of Food Science, Henan Institute of Science and Technology, Xinxiang, 453003, China.
authors.forename: Hanjun
authors.initials: H
authors.lastname: Ma
authors.affiliation: School of Food Science, Henan Institute of Science and Technology, Xinxiang, 453003, China.
authors.forename: Benguo
authors.initials: B
authors.lastname: Liu
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D006038:Glyoxylates / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D006038:Glyoxylates; D002392:Catechin; D000520:alpha-Glucosidases; C031150:glyoxylic acid