title: Glycopeptide antibiotic analogs for selective inactivation and two-photon imaging of vancomycin-resistant strains.
abstract: A novel theranostic divalent vancomycin analog using a planar 1,8-diazapyrene moiety as a rigid scaffold exhibits potent and selective antibacterial activity against Gram (+) bacteria including vancomycin-resistant strains, while having minimal influence on Gram (-) bacteria and mammalian cells. Moreover, this theranostic analog can be also applied for selective two-photon fluorescence imaging of Gram (+) bacteria.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore. shunsuke@ntu.edu.sg bengang@ntu.edu.sg.
authors.forename: Shinya
authors.initials: S
authors.lastname: Ariyasu
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore. shunsuke@ntu.edu.sg bengang@ntu.edu.sg.
authors.forename: Pei Chui
authors.initials: PC
authors.lastname: Too
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore. shunsuke@ntu.edu.sg bengang@ntu.edu.sg.
authors.forename: Jing
authors.initials: J
authors.lastname: Mu
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore, 138648, Singapore.
authors.forename: Chi Ching
authors.initials: CC
authors.lastname: Goh
authors.affiliation: Singapore Centre for Environmental Life Sciences Engineering (SCELSE), School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.
authors.forename: Yichen
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore. shunsuke@ntu.edu.sg bengang@ntu.edu.sg.
authors.forename: Ya Lin
authors.initials: YL
authors.lastname: Tnay
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore. shunsuke@ntu.edu.sg bengang@ntu.edu.sg.
authors.forename: Edwin Kok Lee
authors.initials: EK
authors.lastname: Yeow
authors.affiliation: Singapore Centre for Environmental Life Sciences Engineering (SCELSE), School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.
authors.forename: Liang
authors.initials: L
authors.lastname: Yang
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore, 138648, Singapore.
authors.forename: Lai Guan
authors.initials: LG
authors.lastname: Ng
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore. shunsuke@ntu.edu.sg bengang@ntu.edu.sg.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Chiba
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore. shunsuke@ntu.edu.sg bengang@ntu.edu.sg and Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, 117602, Singapore.
authors.forename: Bengang
authors.initials: B
authors.lastname: Xing
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D006020:Glycopeptides / Q000737:chemistry* / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D008826:Microbial Sensitivity Tests; D064347:Microscopy, Electrochemical, Scanning; D015394:Molecular Structure; D061848:Optical Imaging; D020713:Vancomycin Resistance / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides