title: Antibacterial Activity of Alanine-Derived Gemini Quaternary Ammonium Compounds.
abstract: The antibacterial activity of alanine-derived gemini quaternary ammonium salts (chlorides and bromides) with various spacer and alkyl chain lengths was investigated. The studied compounds exhibited a strong bactericidal effect, especially bromides with 10 and 12 carbon alkyl chains and 3 carbon spacer groups (TMPAL-10 Br and TMPAL-12 Br), with a short contact time. Both salts dislodged biofilms ofPseudomonas aeruginosaandStaphylococcus epidermidis, and were lethal to adherent cells ofS. epidermidis.Bromide with 2 carbon spacer groups and 12 carbon alkyl chains (TMEAL-12 Br) effectively reduced microbial adhesion by coating polystyrene and silicone surfaces. The results obtained suggest that, after further studies, gemini QAS might be considered as antimicrobial agents in medicine or industry.
authors.affiliation: Institute of Genetics and Microbiology, University of Wrocław, Przybyszewskiego 63/77, 51-148 Wrocław, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Piecuch
authors.affiliation: Institute of Genetics and Microbiology, University of Wrocław, Przybyszewskiego 63/77, 51-148 Wrocław, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Obłąk
authors.affiliation: Institute of Genetics and Microbiology, University of Wrocław, Przybyszewskiego 63/77, 51-148 Wrocław, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Guz-Regner
keywords: Adhesion; Biofilm; Gemini quaternary ammonium compounds; Pseudomonas aeruginosa; Staphylococcus epidermidis