title: Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy.
abstract: Cardiovascular disease is a leading cause of death worldwide. Since adult cardiac cells are limited in their proliferation, cardiac tissue with dead or damaged cardiac cells downstream of the occluded vessel does not regenerate after myocardial infarction. The cardiac tissue is then replaced with nonfunctional fibrotic scar tissue rather than new cardiac cells, which leaves the heart weak. The limited proliferation ability of host cardiac cells has motivated investigators to research the potential cardiac regenerative ability of stem cells. Considerable progress has been made in this endeavor. However, the optimum type of stem cells along with the most suitable matrix-material and cellular microenvironmental cues are yet to be identified or agreed upon. This review presents an overview of various types of biofunctional materials and biomaterial matrices, which in combination with stem cells, have shown promises for cardiac tissue replacement and reinforcement. Engineered biomaterials also have applications in cardiac tissue engineering, in which tissue constructs are developed in vitro by combining stem cells and biomaterial scaffolds for drug screening or eventual implantation. This review highlights the benefits of using biomaterials in conjunction with stem cells to repair damaged myocardium and give a brief description of the properties of these biomaterials that make them such valuable tools to the field.
authors.affiliation: Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha, Qatar.|Biomedical Engineering and Departmentof Mechanical Engineering, Faculty of Engineering and Architecture, American University of Beirut, Beirut, 1107 2020, Lebanon.|Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Anwarul
authors.initials: A
authors.lastname: Hasan
authors.affiliation: BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, KS, USA.
authors.forename: Renae
authors.initials: R
authors.lastname: Waters
authors.affiliation: Biomedical Engineering and Departmentof Mechanical Engineering, Faculty of Engineering and Architecture, American University of Beirut, Beirut, 1107 2020, Lebanon.
authors.forename: Boustany
authors.initials: B
authors.lastname: Roula
authors.affiliation: Biomedical Engineering and Departmentof Mechanical Engineering, Faculty of Engineering and Architecture, American University of Beirut, Beirut, 1107 2020, Lebanon.
authors.forename: Rahbani
authors.initials: R
authors.lastname: Dana
authors.affiliation: Biomedical Engineering and Departmentof Mechanical Engineering, Faculty of Engineering and Architecture, American University of Beirut, Beirut, 1107 2020, Lebanon.
authors.forename: Seif
authors.initials: S
authors.lastname: Yara
authors.affiliation: Biomedical Engineering and Departmentof Mechanical Engineering, Faculty of Engineering and Architecture, American University of Beirut, Beirut, 1107 2020, Lebanon.
authors.forename: Toubia
authors.initials: T
authors.lastname: Alexandre
authors.affiliation: BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, KS, USA.
authors.forename: Arghya
authors.initials: A
authors.lastname: Paul
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000235:genetics; D006321:Heart / Q000254:growth & development* / Q000503:physiopathology; D006801:Humans; D009203:Myocardial Infarction / Q000628:therapy*; D012038:Regeneration; D033581:Stem Cell Transplantation; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials
keywords: angiogenesis; hydrogel; myocardial infarction; nanomedicine; stem cells