title: Evaluation of anorganic bovine-derived hydroxyapatite matrix/cell binding peptide as a bone graft material in the treatment of human periodontal infrabony defects: A clinico-radiographic study.
abstract: BACKGROUND
  Various bone graft materials have been used in the treatment of periodontal defects. A synthetic bone substitute material composed of P-15 with anorganic bone mineral has been scantly studied. Hence, the present study was aimed to evaluate and compare the efficacy of anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) in human periodontal infrabony defects with that of open flap debridement (OFD) alone.
  
  
  METHODS
  A split-mouth, randomized controlled clinical study was designed to investigate the efficacy of ABM/P-15. In this clinical trial, 10 patients having bilateral periodontal infrabony defects were treated either with ABM/P-15 or OFD and followed for a period of 9 months. At baseline and at 9 months probing pocket depth (PPD), relative attachment level (RAL), depth of a defect, and radiographic bone level were measured; and compared between test and control sites.
  
  
  RESULTS
  A statistically significant reduction (P < 0.001) in PPD was observed in test sites compared to control sites. Both sites showed a gain in RAL without any significant difference. Similarly, the radiographic evaluation revealed significantly higher radiographic defect fill in test sites as compared to control sites (P < 0.001).
  
  
  CONCLUSIONS
  ABM/P-15 bone graft material appears to be useful and beneficial in the treatment of human periodontal infrabony defects.
authors.affiliation: Department of Periodontics, Al-Badar Dental College and Hospital, Gulbarga, Karnataka, India.
authors.forename: Ghousia
authors.initials: G
authors.lastname: Fatima
authors.affiliation: Department of Periodontics, Sri Hassanamba Dental College, Hassan, Karnataka, India.
authors.forename: Ravindra
authors.initials: R
authors.lastname: Shivamurthy
authors.affiliation: Department of Periodontics, SDM Dental College and Hospital, Dharwad, Karnataka, India.
authors.forename: Srinath
authors.initials: S
authors.lastname: Thakur
authors.affiliation: Department of Preventive Dentistry, Riyadh Colleges of Dentistry and Pharmacy, Riyadh, Saudi Arabia.
authors.forename: Mohammad Abdul
authors.initials: MA
authors.lastname: Baseer
keywords: Cell binding peptide P-15; grafts; hydroxyapatite; periodontal disease; periodontal regeneration