title: Iron oxide nanoparticles as magnetic relaxation switching (MRSw) sensors: Current applications in nanomedicine.
abstract: Since pioneering work in the early 60s on the development of enzyme electrodes the field of sensors has evolved to different sophisticated technological platforms. Still, for biomedical applications, there are key requirements to meet in order to get fast, low-cost, real-time data acquisition, multiplexed and automatic biosensors. Nano-based sensors are one of the most promising healthcare applications of nanotechnology, and prone to be one of the first to become a reality. From all nanosensors strategies developed, Magnetic Relaxation Switches (MRSw) assays combine several features which are attractive for nanomedical applications such as safe biocompatibility of magnetic nanoparticles, increased sensitivity/specificity measurements, possibility to detect analytes in opaque samples (unresponsive to light-based interferences) and the use of homogeneous setting assay. This review aims at presenting the ongoing progress of MRSw technology and its most important applications in clinical medicine.
authors.affiliation: BIONAND, Andalusian Center for Nanomedicine and Biotechnology, Campanillas, Malaga, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Alcantara
authors.affiliation: CABIMER, Andalusian Center for molecular Biology and Regenerative Medicine, Isla de la Cartuja, Seville, Spain; Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, Seville, Spain.
authors.forename: Soledad
authors.initials: S
authors.lastname: Lopez
authors.affiliation: BIONAND, Andalusian Center for Nanomedicine and Biotechnology, Campanillas, Malaga, Spain.
authors.forename: María Luisa
authors.initials: ML
authors.lastname: García-Martin
authors.affiliation: CABIMER, Andalusian Center for molecular Biology and Regenerative Medicine, Isla de la Cartuja, Seville, Spain; Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, Seville, Spain. Electronic address: david.pozo@cabimer.es.
authors.forename: David
authors.initials: D
authors.lastname: Pozo
mesh_terms: D015374:Biosensing Techniques; D006801:Humans; D008280:Magnetics; D050997:Nanomedicine; D053758:Nanoparticles; D036103:Nanotechnology
keywords: Biosensors; Magnetic nanoparticles; Magnetic resonance; Nanodiagnostics; Nanoengineering; Nanomedical devices