title: Ultrasound-Accelerated Thrombolysis in Patients With Intracardiac Thrombi: A Case Series.
abstract: We describe a case series of 3 patients presenting with intracardiac thrombi treated with standard anticoagulation therapy and intervention with ultrasound-accelerated thrombolysis therapy. Right-sided intracardiac thrombi portend significant mortality due to their susceptibility for embolization and pulmonary embolus despite the continuation of current standard of therapy of parenteral anticoagulation and surgical embolectomy if warranted. We demonstrate the safety and clinical efficacy of ultrasound-accelerated thrombolysis therapy with the EkoSonic Endovascular System infusion catheter system (EKOS Corporation) and highlight its use in resolving intracardiac thrombi and impeding the propagation of pulmonary emboli.
authors.forename: Ajay
authors.initials: A
authors.lastname: Yadlapati
authors.forename: Ranya
authors.initials: R
authors.lastname: Sweis
authors.affiliation: Interventional Cardiology, Northwestern University Feinberg School of Medicine, Division of Cardiology, 676 N. St. Clair Street, Suite 600, Chicago, IL 60611-2996 USA. dschimme@nm.org.
authors.forename: Daniel
authors.initials: D
authors.lastname: Schimmel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015150:Echocardiography, Doppler; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006331:Heart Diseases / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000175:diagnosis / Q000628:therapy*; D014464:Ultrasonic Therapy / Q000379:methods*
chemical_list: D005343:Fibrinolytic Agents