title: Bone Quality in Paget's Disease of Bone.
abstract: Paget's disease of bone is produced by a localized increase in osteoclastic and osteoblastic activity which can progress slowly to involve an entire bone if untreated. A common feature is enlarged bones which are deformed, particularly in weight-bearing regions of the skeleton such as the lower extremity. Pathologic fractures may be a consequence, and nonunion of femoral fractures is not uncommon. Analyses of bone biopsies from patients with Paget's disease indicate that there is a lower, heterogeneous degree of bone mineralization and a younger tissue age than that found in control bone. Pagetic bone also has less resistance to plastic deformation and a straighter crack path than control bone.
authors.affiliation: Endocrine/Bone Disease Program, John Wayne Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA. singer@jwci.org.|Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. singer@jwci.org.
authors.forename: Frederick R
authors.initials: FR
authors.lastname: Singer
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000002:abnormalities* / Q000737:chemistry / Q000473:pathology* / Q000503:physiopathology; D002113:Calcification, Physiologic; D003094:Collagen / Q000032:analysis; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology; D006801:Humans; D010001:Osteitis Deformans / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology
chemical_list: D003094:Collagen