title: Relaxin Treatment in an Ang-II-Based Transgenic Preeclamptic-Rat Model.
abstract: Relaxin is a peptide related to pregnancy that induces nitric oxide-related and gelatinase-related effects, allowing vasodilation and pregnancy-related adjustments permitting parturition to occur. Relaxin controls the hemodynamic and renovascular adaptive changes that occur during pregnancy. Interest has evolved regarding relaxin and a therapeutic principle in preeclampsia and heart failure. Preeclampsia is a pregnancy disorder, featuring hypertension, proteinuria and placental anomalies. We investigated relaxin in an established transgenic rat model of preeclampsia, where the phenotype is induced by angiotensin (Ang)-II production in mid pregnancy. We gave recombinant relaxin to preeclamtic rats at day 9 of gestation. Hypertension and proteinuria was not ameliorated after relaxin administration. Intrauterine growth retardation of the fetus was unaltered by relaxin. Heart-rate responses and relaxin levels documented drug effects. In this Ang-II-based model of preeclampsia, we could not show a salubrious effect on preeclampsia.
authors.affiliation: Experimental and Clinical Research Center, a joint cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz and the Charité Medical Faculty, Berlin, Germany.
authors.forename: Nadine
authors.initials: N
authors.lastname: Haase
authors.affiliation: Experimental and Clinical Research Center, a joint cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz and the Charité Medical Faculty, Berlin, Germany.
authors.forename: Michaela
authors.initials: M
authors.lastname: Golic
authors.affiliation: Experimental and Clinical Research Center, a joint cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz and the Charité Medical Faculty, Berlin, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Herse
authors.affiliation: Experimental and Clinical Research Center, a joint cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz and the Charité Medical Faculty, Berlin, Germany.
authors.forename: Julianna
authors.initials: J
authors.lastname: Rugor
authors.affiliation: Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Linz
authors.affiliation: Department of Obstetrics and Fetal Medicine, Laboratory for Experimental Feto-Maternal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Maria Emilia
authors.initials: ME
authors.lastname: Solano
authors.affiliation: Experimental and Clinical Research Center, a joint cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz and the Charité Medical Faculty, Berlin, Germany.
authors.forename: Dominik N
authors.initials: DN
authors.lastname: Müller
authors.affiliation: Experimental and Clinical Research Center, a joint cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz and the Charité Medical Faculty, Berlin, Germany.|HELIOS-Klinikum Berlin, Berlin, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Dechend
mesh_terms: D000809:Angiotensins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005317:Fetal Growth Retardation / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D055647:Rats, Transgenic; D012065:Relaxin / Q000494:pharmacology*
chemical_list: D000809:Angiotensins; D012065:Relaxin