title: Hierarchical electrodeposition of methylene blue on ZnO nanocrystals thin films layered on SnO2/F electrode for in vitro sensing of anti-thalassemic drug.
abstract: Zinc oxide nanocrystals-methylene blue nanocomposites were developed by electrodeposition of methylene blue onto the thin films of zinc oxide nanocrystals deposited onto SnO2/F coated glass substrates for in vitro sensing of anti-thalassemic drug i.e. deferiprone. Detailed morphological, electrochemical, structural and optical characterizations of ZnONC-MB/FTO electrode were done using XRD, SEM, EIS, FTIR, LSV, and CV and show quick response time (within 5 s), linearity as 1 × 10(-3) to 10(3) μM and shelf life of about 10 weeks under refrigerated conditions. Attempts have been made to utilize this electrode for estimation of deferiprone in urine samples. The developed sensor exhibited high reproducibility and good storage stability.
authors.affiliation: Amity Institute of Nanotechnology, Amity University, Noida, UP, India.
authors.forename: Chaitali
authors.initials: C
authors.lastname: Singhal
authors.affiliation: Amity Institute of Physiotherapy, Amity University, Noida, UP, India.
authors.forename: Nitesh
authors.initials: N
authors.lastname: Malhotra
authors.affiliation: Amity Institute of Nanotechnology, Amity University, Noida, UP, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Chauhan
authors.affiliation: Oil and Natural Gas Corporation (ONGC), India.
authors.forename: Sumit
authors.initials: S
authors.lastname: Narang
authors.affiliation: Dept. of Biochemistry, MD University, Rohtak 124001, India.
authors.forename: C S
authors.initials: CS
authors.lastname: Pundir
authors.affiliation: Amity Institute of Nanotechnology, Amity University, Noida, UP, India. Electronic address: jags_biotech@yahoo.co.in.
authors.forename: Jagriti
authors.initials: J
authors.lastname: Narang
mesh_terms: D002138:Calibration; D000077543:Deferiprone; D055664:Electrochemical Techniques / Q000592:standards; D004566:Electrodes; D004595:Electroplating; D005461:Fluorine / Q000737:chemistry; D007502:Iron Chelating Agents / Q000032:analysis* / Q000592:standards; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D008751:Methylene Blue / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011728:Pyridones / Q000032:analysis / Q000592:standards; D017550:Spectroscopy, Fourier Transform Infrared; D017971:Tin Compounds / Q000737:chemistry; D014961:X-Ray Diffraction; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D007502:Iron Chelating Agents; D011728:Pyridones; D017971:Tin Compounds; D005461:Fluorine; D000077543:Deferiprone; C045358:stannic oxide; D015034:Zinc Oxide; D008751:Methylene Blue
keywords: Composites; Deferiprone; Methylene blue; Sensor; SnO(2)/F; Thalassemia; Zinc oxide nanocrystals