title: Noralashinol A, a new norlignan from stem barks of Syringa pinnatifolia.
abstract: One new norlignan, namely noralashinol A (1), one known analogue (2), together with seven known lignans (3-9) were isolated from the stem barks of Syringa pinnatifolia. Their structures were elucidated extensively by spectroscopic methods, including mass spectrometry and 1D and 2D NMR spectroscopies. Compound 8 significantly inhibited NO production in LPS-induced BV-2 murine microglia cells with its IC50 value of 20.7 μM, compared to a positive control quercetin with its IC50 value of 15.3 μM.
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
authors.forename: Guozhu
authors.initials: G
authors.lastname: Su
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
authors.forename: Ruifeng
authors.initials: R
authors.lastname: Bai
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
authors.forename: Xuelong
authors.initials: X
authors.lastname: Yu
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Cao
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yin
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Tu
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , China.
authors.forename: Xingyun
authors.initials: X
authors.lastname: Chai
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical / Q000379:methods; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D009284:Naphthols / Q000302:isolation & purification / Q000494:pharmacology*; D009569:Nitric Oxide / Q000096:biosynthesis; D024301:Plant Bark / Q000737:chemistry; D031662:Syringa / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D017705:Lignans; D008070:Lipopolysaccharides; D009284:Naphthols; D009569:Nitric Oxide
keywords: Syringa pinnatifolia; anti-inflammatory activity; noralashinol A