title: Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development.
abstract: Primary cilia are unique sensory organelles that coordinate cellular signaling networks in vertebrates. Inevitably, defects in the formation or function of primary cilia lead to imbalanced regulation of cellular processes that causes multisystemic disorders and diseases, commonly known as ciliopathies. Mounting evidence has demonstrated that primary cilia coordinate multiple activities that are required for cell migration, which, when they are aberrantly regulated, lead to defects in organogenesis and tissue repair, as well as metastasis of tumors. Here, we present an overview on how primary cilia may contribute to the regulation of the cellular signaling pathways that control cyclic processes in directional cell migration.
authors.affiliation: Iben Rønn Veland ( irveland@bio.ku.dk ) is a postdoctoral researcher from the Christensen Lab, at the University of Copenhagen, Denmark, and she studies the role of primary cilia in cell polarization and migration. Louise Lindbæk ( llindbaek@bio.ku.dk ) is a PhD student in the Christensen Lab, and she studies the function of primary cilia in neurogenesis and brain development. Søren Tvorup Christensen ( stchristensen@bio.ku.dfk ) is a professor at the University of Copenhagen. He studies how primary cilia coordinate signaling pathways during development and in tissue homeostasis.
authors.forename: Iben Rønn
authors.initials: IR
authors.lastname: Veland
authors.affiliation: Iben Rønn Veland ( irveland@bio.ku.dk ) is a postdoctoral researcher from the Christensen Lab, at the University of Copenhagen, Denmark, and she studies the role of primary cilia in cell polarization and migration. Louise Lindbæk ( llindbaek@bio.ku.dk ) is a PhD student in the Christensen Lab, and she studies the function of primary cilia in neurogenesis and brain development. Søren Tvorup Christensen ( stchristensen@bio.ku.dfk ) is a professor at the University of Copenhagen. He studies how primary cilia coordinate signaling pathways during development and in tissue homeostasis.
authors.forename: Louise
authors.initials: L
authors.lastname: Lindbæk
authors.affiliation: Iben Rønn Veland ( irveland@bio.ku.dk ) is a postdoctoral researcher from the Christensen Lab, at the University of Copenhagen, Denmark, and she studies the role of primary cilia in cell polarization and migration. Louise Lindbæk ( llindbaek@bio.ku.dk ) is a PhD student in the Christensen Lab, and she studies the function of primary cilia in neurogenesis and brain development. Søren Tvorup Christensen ( stchristensen@bio.ku.dfk ) is a professor at the University of Copenhagen. He studies how primary cilia coordinate signaling pathways during development and in tissue homeostasis.
authors.forename: Søren Tvorup
authors.initials: ST
authors.lastname: Christensen
keywords: cell migration; cell polarity; cellular signaling; development; primary cilia; tissue repair