title: Calcium homeostasis modulator 1 gene P86L polymorphism and the risk for alzheimer's disease: A meta-analysis.
abstract: OBJECTIVE
  Recently, many epidemiological studies have demonstrated an association between P86L polymorphism of calcium homeostasis modulator 1 (CALHM1) and risk for Alzheimer's disease (AD). However, the results of these association studies are inconsistent. In this study, we re-evaluated the relation between CALHM1 P86L polymorphism and risk for AD in a meta-analysis.
  
  
  METHODS
  This meta-analysis was performed using the PubMed, Science Direct, Scopus and Google Scholar databases up to June 2015 using the search terms "CALHM1" and "polymorphism or SNP or variant" in combination with "Alzheimer's disease". A meta-analysis with pooled odds ratios and 95% confidence intervals was carried out to assess the associations between P86L polymorphism and the risks for Alzheimer's disease under four genetic models with fixed or random effects models.
  
  
  RESULTS
  Sixteen studies (twenty-four subgroup studies involving 9795 cases and 15,335 controls) were included in our meta-analysis. Our meta-analysis results indicated that several genetic models of CALHM1 P86L polymorphism were significantly associated with increased risk for AD in overall and Caucasian populations.
  
  
  CONCLUSIONS
  In conclusion, our comprehensive meta-analysis indicated that P86L polymorphism is significantly associated with an increased risk for AD. Our data suggest that CALHM1 polymorphism may be potential biomarker in patients with AD.
authors.affiliation: Department of Chemistry, School of Natural Science, Dankook University, Cheonan 330-714, South Korea; Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University Graduate School, South Korea; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, South Korea.
authors.forename: Myung-Jin
authors.initials: MJ
authors.lastname: Mun
authors.affiliation: Department of Chemistry, School of Natural Science, Dankook University, Cheonan 330-714, South Korea.
authors.forename: Jin-Ho
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Chemistry, School of Natural Science, Dankook University, Cheonan 330-714, South Korea.
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Department of Chemistry, School of Natural Science, Dankook University, Cheonan 330-714, South Korea. Electronic address: wcjang@dankook.ac.kr.
authors.forename: Won-Cheoul
authors.initials: WC
authors.lastname: Jang
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D015220:Calcium Channels / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C530077:CALHM1 protein, human; D015220:Calcium Channels; D008562:Membrane Glycoproteins
keywords: Alzheimer’s disease; Calcium homeostasis modulator 1; Meta-analysis; Polymorphism