title: Relationship between thioredoxin and thioredoxin-binding protein in patients with gestational diabetes mellitus.
abstract: OBJECTIVE
  This study examined the clinical and biological significance of thioredoxin (Trx) and thioredoxin-binding protein (TrxBP), which are redox-active proteins that control multiple biological functions, in gestational diabetes.
  
  
  METHODS
  We measured serum concentrations of Trx, TrxBP, insulin and other blood parameters, as well as insulin resistance and glucose tolerance in pregnant women with or without gestational dieabetes mellitus (GDM) (34/34) at the early second trimester.
  
  
  RESULTS
  Contrary to diabetes patients, serum TrxBP levels were lower in women with GDM than healthy pregnant controls. The serum insulin concentrations were higher in GDM, but the difference was not statistically significant. Furthermore, the intracellular redox potential ratio (Trx/TrxBP) of GDM patients was higher than that of the control group.
  
  
  CONCLUSIONS
  During pregnancy, the mother is potentially subjected to glucotoxicity as well as oxidative stress (OS) to help the foetus absorb more nutrients. Our results suggest that the Trx/TrxBP system may mediate a compensating mechanism. Reduced TrxBP levels and consequent enhanced Trx activity may alleviate OS and protect the foetus from hypoglycaemia. We hypothesise that the decrease in TrxBP levels is not a consequence of GDM, but rather is an instance of the active functional role of TrxBP in maternal development, unifying redox regulation and glucose metabolism.
authors.affiliation: a Department of Clinical Biochemistry , Central Laboratories of Antalya Training and Research Hospital , Antalya , Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Eren
authors.affiliation: a Department of Clinical Biochemistry , Central Laboratories of Antalya Training and Research Hospital , Antalya , Turkey.
authors.forename: Guzin
authors.initials: G
authors.lastname: Aykal
authors.affiliation: b Research and Development Unit, Antalya Association of Public Hospitals , Antalya , Turkey , and.
authors.forename: Suha
authors.initials: S
authors.lastname: Sayrac
authors.affiliation: c Department of Gynecology and Obstetrics , Antalya Training and Research Hospital , Antalya , Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Erol
authors.affiliation: a Department of Clinical Biochemistry , Central Laboratories of Antalya Training and Research Hospital , Antalya , Turkey.
authors.forename: Hamit Yasar
authors.initials: HY
authors.lastname: Ellidag
authors.affiliation: a Department of Clinical Biochemistry , Central Laboratories of Antalya Training and Research Hospital , Antalya , Turkey.
authors.forename: Necat
authors.initials: N
authors.lastname: Yilmaz
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002352:Carrier Proteins / Q000097:blood*; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015999:Multivariate Analysis; D018384:Oxidative Stress; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000378:metabolism; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D013879:Thioredoxins / Q000097:blood*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D002352:Carrier Proteins; D007328:Insulin; D013879:Thioredoxins
keywords: Gestational diabetes; glucose metabolism; glucotoxicity; oxidative stress; thioredoxin; thioredoxin-binding protein