title: [STUDY OF THE ROLE OF INNATE IMMUNITY FACTORS (TLR2, HBD-2, TNF-α, TGF-β) IN PERIODONTITIS PATHOGENESIS].
abstract: OBJECTIVE
  Study of the role of innate immunity factors, namely, expression of TLR2 and HBD-2 genes, as well as TNF-α arid TGF-β in pathogenesis of periodontium tissue inflammation.
  
  
  METHODS
  59 individuals with periodontitis illnesses were included into the study; 15 healthy donors represented the comparison group. Study of the TLR2 and HBD-2 gene expression levels was carried out by rRT-PCR, cytokine production evaluation--by EIA.
  
  
  RESULTS
  The results of the study have shown the presence of TLR-mediated disbalance in the innate immunity system in the periodontium tissue during chronic generalized periodontitis. TLR2 gene hyperexpression was accompanied by the reduction of expression of anti-microbial peptide HBD-2, as well as an increase of production of TNF-αand TGF-P by epithelial cells of periodontium mucosa. Conclusion.-The study carried out has shown that disturbance of molecular mechanisms of innate immunity system has an important place in pathogenesis of periodontitis. -
authors.forename: L V
authors.initials: LV
authors.lastname: Gankovskaya
authors.forename: N M
authors.initials: NM
authors.lastname: Helminskaya
authors.forename: O A
authors.initials: OA
authors.lastname: Svitich
authors.forename: E A
authors.initials: EA
authors.lastname: Molchanova
authors.forename: V V
authors.initials: VV
authors.lastname: Grechenko
authors.forename: E V
authors.initials: EV
authors.lastname: Sokolova
authors.forename: K V
authors.initials: KV
authors.lastname: Rusanova
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004847:Epithelial Cells / Q000276:immunology / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000276:immunology / Q000473:pathology; D010518:Periodontitis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D010519:Periodontium / Q000276:immunology* / Q000473:pathology; D015398:Signal Transduction; D051195:Toll-Like Receptor 2 / Q000235:genetics / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology*; D023083:beta-Defensins / Q000235:genetics / Q000276:immunology*
chemical_list: C106641:DEFB4A protein, human; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D023083:beta-Defensins