title: High intercorneal symmetry in corneal biomechanical metrics.
abstract: BACKGROUND
  To evaluate the symmetry of corneal biomechanical metrics, measured using an ocular response analyzer (ORA) and self-built corneal inflation test platform, in bilateral rabbit corneas and to investigate their relationship with physical intraocular pressure (IOPp).
  
  
  METHODS
  Twenty fresh enucleated eyes from ten rabbits were used for ex vivo whole ocular globe inflation. IOP was increased from 7.5 to 37.5 mmHg with 7.5 mmHg steps and biomechanical metrics were acquired using the ORA. At least 3 examinations were performed at each pressure stage. Two biomechanical metrics, corneal hysteresis (CH) and corneal resistance factor (CRF) were recorded and analyzed as a function of IOPp. Corneal specimens were then excised from the intact ocular globe and tested under inflation conditions up to 45.7 mmHg posterior pressure. The experimental pressure-deformation data was analyzed using an inverse modeling procedure to derive the stress-strain behavior of the cornea.
  
  
  RESULTS
  A comparison of corneal shape parameters showed no statistically significant difference (P > 0.05) between bilateral eyes. Similarly, there were no statistically significant differences in values of CH, CRF and corneal stiffness (as measured by the tangent modulus, Et) between bilateral eyes (CH: F = 0.94, P = 0.54; CRF: F = 4.42, P = 0.35; Et: F = 3.15, P = 0.12) at different pressure levels. IOPp was highly correlated with CRF while the relationship with CH was less pronounced.
  
  
  CONCLUSIONS
  An obvious interocular symmetry in biomechanical metrics is found in this research. IOP has been shown to have important influences on the value of CRF provided by ORA.
authors.affiliation: The Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province 325027 China ; The Institution of Ocular Biomechanics, Eye Hospital, Wenzhou Medical University, No. 270# Xueyuan West Road, Wenzhou City, Zhejiang Province 325027 China.
authors.forename: XiaoBo
authors.initials: X
authors.lastname: Zheng
authors.affiliation: The Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province 325027 China ; The Institution of Ocular Biomechanics, Eye Hospital, Wenzhou Medical University, No. 270# Xueyuan West Road, Wenzhou City, Zhejiang Province 325027 China.
authors.forename: FangJun
authors.initials: F
authors.lastname: Bao
authors.affiliation: School of Engineering, University of Liverpool, Liverpool, L69 3GH UK.
authors.forename: Brendan
authors.initials: B
authors.lastname: Geraghty
authors.affiliation: The Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province 325027 China ; The Institution of Ocular Biomechanics, Eye Hospital, Wenzhou Medical University, No. 270# Xueyuan West Road, Wenzhou City, Zhejiang Province 325027 China.
authors.forename: JinHai
authors.initials: J
authors.lastname: Huang
authors.affiliation: The Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province 325027 China ; The Institution of Ocular Biomechanics, Eye Hospital, Wenzhou Medical University, No. 270# Xueyuan West Road, Wenzhou City, Zhejiang Province 325027 China.
authors.forename: Ayong
authors.initials: A
authors.lastname: Yu
authors.affiliation: The Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province 325027 China ; The Institution of Ocular Biomechanics, Eye Hospital, Wenzhou Medical University, No. 270# Xueyuan West Road, Wenzhou City, Zhejiang Province 325027 China.
authors.forename: QinMei
authors.initials: Q
authors.lastname: Wang
keywords: Corneal biomechanical metrics; Corneal stiffness; Intercorneal symmetry; Ocular response analyzer