title: Prescribers' behavior following below- versus above-range international normalized ratio values in warfarin-treated deep vein thrombosis patients.
abstract: Maintaining acceptable international normalized ratio (INR) control among deep vein thrombosis (DVT) patients taking warfarin is challenging. We evaluated prescribers' behavior to out-of-range INRs in DVT patients following initial INR stabilization. Following INR stabilization, a below-range INR was associated with fewer subsequent measurements and warfarin-dosing adjustments, and a longer time to re-achieve a therapeutic INR compared to an above-range INR.
authors.affiliation: a Janssen Scientific Affairs LLC , Raritan , NJ , USA ;
authors.forename: Monika K
authors.initials: MK
authors.lastname: Raut
authors.affiliation: a Janssen Scientific Affairs LLC , Raritan , NJ , USA ;
authors.forename: Winnie W
authors.initials: WW
authors.lastname: Nelson
authors.affiliation: b Janssen Research and Development LLC , Raritan , NJ , USA ;
authors.forename: Sheng-Wei
authors.initials: SW
authors.lastname: Wang
authors.affiliation: c The University of Connecticut Evidence-Based Practice Center , Hartford , CT , USA ;|d University of Connecticut School of Pharmacy , Storrs , CT , USA ;
authors.forename: Craig I
authors.initials: CI
authors.lastname: Coleman
authors.affiliation: b Janssen Research and Development LLC , Raritan , NJ , USA ;
authors.forename: Lang
authors.initials: L
authors.lastname: Lu
authors.affiliation: e University of the Sciences, Philadelphia College of Pharmacy , Philadelphia , PA , USA.
authors.forename: Dhaval
authors.initials: D
authors.lastname: Patel
authors.affiliation: a Janssen Scientific Affairs LLC , Raritan , NJ , USA ;
authors.forename: Jeff R
authors.initials: JR
authors.lastname: Schein
authors.affiliation: b Janssen Research and Development LLC , Raritan , NJ , USA ;
authors.forename: Jim
authors.initials: J
authors.lastname: Xiang
authors.affiliation: b Janssen Research and Development LLC , Raritan , NJ , USA ;
authors.forename: C V
authors.initials: CV
authors.lastname: Damaraju
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D019934:International Normalized Ratio / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D020246:Venous Thrombosis / Q000188:drug therapy*; D014859:Warfarin / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D014859:Warfarin
keywords: Deep vein thrombosis; International normalized ratio; Vitamin K antagonist; Warfarin