title: Satellite Cell Heterogeneity in Skeletal Muscle Homeostasis.
abstract: The cellular turnover required for skeletal muscle maintenance and repair is mediated by resident stem cells, also termed satellite cells. Satellite cells normally reside in a quiescent state, intermittently entering the cell cycle to fuse with neighboring myofibers and replenish the stem cell pool. However, the mechanisms by which satellite cells maintain the precise balance between self-renewal and differentiation necessary for long-term homeostasis remain unclear. Recent work has supported a previously unappreciated heterogeneity in the satellite cell compartment that may underlie the observed variability in cell fate and function. In this review, we examine the work supporting this notion as well as the potential governing principles, developmental origins, and principal determinants of satellite cell heterogeneity.
authors.affiliation: Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, 10901N Torrey Pines Road, La Jolla, CA 92037, USA; Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, 10901N Torrey Pines Rd, La Jolla, CA 92037, USA.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Tierney
authors.affiliation: Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, 10901N Torrey Pines Rd, La Jolla, CA 92037, USA. Electronic address: asacco@sbpdiscovery.org.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Sacco
mesh_terms: D000818:Animals; D002451:Cell Compartmentation; D000066673:Cell Self Renewal; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000166:cytology*; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology*
keywords: plasticity; satellite cells; skeletal muscle; stem cell heterogeneity