title: A multimodal approach to dementia prevention: A report from the Cambridge Institute of Public Health.
abstract: BACKGROUND
  Globally, dementia is the most frequent form of degenerative condition in the older adult population and poses a major health burden with high socioeconomic costs. So far, attempts to find pharmacologic interventions that can change the onset or progression of dementia have been largely unsuccessful, prompting a shift to focus on interventions aimed at modifying risk factors that occur throughout the life course.
  
  
  METHODS
  The Cognitive Function and Ageing Studies, funded by the Medical Research Council, UK, convened three multidisciplinary groups of experts, expert witnesses, and advocates to discuss the state of evidence on primary, secondary, and tertiary dementia prevention and recommend future direction for intervention studies.
  
  
  RESULTS
  Using the United Kingdom Parliamentary Select Committees' approach to gathering evidence, the primary prevention working group focused their deliberation on risk factors strongly associated with dementia. The group highlighted the need for high-quality studies to assess the effects of behavioral intervention on the delay of cognitive decline and dementia onset.
  
  
  CONCLUSIONS
  The working group recommended that the development of a future dementia prevention trial should use a multimodal, multifactor, multilevel, community and individually tailored approach.
authors.affiliation: Department of Public Health and Primary Care, Cambridge Institute of Public Health, Cambridge, UK.
authors.forename: Olawale
authors.initials: O
authors.lastname: Olanrewaju
authors.affiliation: REACH: The Centre for Research in Aging and Cognitive Health, Department of Psychology, College of Life and Environmental Sciences, University of Exeter University (Professor Linda Clare).
authors.forename: Linda
authors.initials: L
authors.lastname: Clare
authors.affiliation: Department of Public Health and Primary Care, Cambridge Institute of Public Health, Cambridge, UK.
authors.forename: Linda
authors.initials: L
authors.lastname: Barnes
authors.affiliation: Department of Public Health and Primary Care, Cambridge Institute of Public Health, Cambridge, UK.
authors.forename: Carol
authors.initials: C
authors.lastname: Brayne
keywords: Aging; Cognitive decline; Dementia; Expert review; Non-pharmacological intervention; Preventive health