title: Food-derived immunomodulatory peptides.
abstract: Food proteins contain specific amino acid sequences within their structures that may positively impact bodily functions and have multiple immunomodulatory effects. The functional properties of these specific sequences, also referred to as bioactive peptides, are revealed only after the degradation of native proteins during digestion processes. Currently, milk proteins have been the most explored source of bioactive peptides, which presents an interesting opportunity for the dairy industry. However, plant- and animal-derived proteins have also been shown to be important sources of bioactive peptides. This review summarizes the in vitro and in vivo evidence of the role of various food proteins as sources of immunomodulatory peptides and discusses the possible pathways involving these properties. © 2016 Society of Chemical Industry.
authors.affiliation: Laboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo, AC (CIAD), Carretera a La Victoria Km 0.6, 83304, Hermosillo, Sonora, Mexico.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Santiago-López
authors.affiliation: Laboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo, AC (CIAD), Carretera a La Victoria Km 0.6, 83304, Hermosillo, Sonora, Mexico.
authors.forename: Adrián
authors.initials: A
authors.lastname: Hernández-Mendoza
authors.affiliation: Laboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo, AC (CIAD), Carretera a La Victoria Km 0.6, 83304, Hermosillo, Sonora, Mexico.
authors.forename: Belinda
authors.initials: B
authors.lastname: Vallejo-Cordoba
authors.affiliation: Laboratorio de Microbiología e Inmunología, Centro de Investigación en Alimentación y Desarrollo, AC (CIAD), Carretera a La Victoria Km 0.6, 83304, Hermosillo, Sonora, Mexico.
authors.forename: Verónica
authors.initials: V
authors.lastname: Mata-Haro
authors.affiliation: Laboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo, AC (CIAD), Carretera a La Victoria Km 0.6, 83304, Hermosillo, Sonora, Mexico.
authors.forename: Aarón F
authors.initials: AF
authors.lastname: González-Córdova
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004032:Diet; D004044:Dietary Proteins / Q000494:pharmacology*; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D008894:Milk Proteins / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D010940:Plant Proteins / Q000494:pharmacology
chemical_list: D004044:Dietary Proteins; D008894:Milk Proteins; D010455:Peptides; D010940:Plant Proteins
keywords: food proteins; immunomodulatory peptides