title: Vancomycin Functionalized Nanoparticles for Bactericidal Biomaterial Surfaces.
abstract: In this paper, we describe a simple and powerful way to synthesize antibacterial biomaterials with applications as implants in orthopedic surgery. Such implants are obtained by covalently grafting onto the Ti90A16 V4 alloy surface with vancomycin-functionalized nanoparticles. Nanoparticles were produced by ring-opening metathesis polymerization of α-norbornenyl-ω-vancomycin poly(ethylene oxide) macromonomers. Vancomycin is an interesting candidate because of its use in the field of implant associated infection as it is a glycopeptide which acts on bacterial walls. As a consequence, vancomycin does not need to be released for it to be active. In the first part of this paper, the synthesis and the complete characterization of these materials are described. In a second part, the in vitro antibacterial behavior is analyzed and discussed.
authors.affiliation: CNRS UMR5629, Laboratoire de Chimie des Polymères Organiques, IPB-ENSCBP, Université de Bordeaux, 16 avenue Pey Berland, F-33607 Pessac, France.|CNRS UMR5248, Institut de Chimie & Biologie des Membranes & des Nanoobjets, Université de Bordeaux, INP Bordeaux, 2 rue Robert Escarpit, F-33607 cedex Pessac France.
authors.forename: Loïc
authors.initials: L
authors.lastname: Pichavant
authors.affiliation: CNRS UMR5629, Laboratoire de Chimie des Polymères Organiques, IPB-ENSCBP, Université de Bordeaux, 16 avenue Pey Berland, F-33607 Pessac, France.|CNRS UMR5248, Institut de Chimie & Biologie des Membranes & des Nanoobjets, Université de Bordeaux, INP Bordeaux, 2 rue Robert Escarpit, F-33607 cedex Pessac France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Carrié
authors.affiliation: CNRS UMR5629, Laboratoire de Chimie des Polymères Organiques, IPB-ENSCBP, Université de Bordeaux, 16 avenue Pey Berland, F-33607 Pessac, France.|Faculty of Chemistry, VNU University of Science , Hanoi, 19 Le Thanh Tong, Hoan Kiem, Hanoi, Vietnam.
authors.forename: Minh Ngoc
authors.initials: MN
authors.lastname: Nguyen
authors.affiliation: CNRS UMR5248, Institut de Chimie & Biologie des Membranes & des Nanoobjets, Université de Bordeaux, INP Bordeaux, 2 rue Robert Escarpit, F-33607 cedex Pessac France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Plawinski
authors.affiliation: CNRS UMR5248, Institut de Chimie & Biologie des Membranes & des Nanoobjets, Université de Bordeaux, INP Bordeaux, 2 rue Robert Escarpit, F-33607 cedex Pessac France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Durrieu
authors.affiliation: CNRS UMR5629, Laboratoire de Chimie des Polymères Organiques, IPB-ENSCBP, Université de Bordeaux, 16 avenue Pey Berland, F-33607 Pessac, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Héroguez
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000737:chemistry; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D019736:Prostheses and Implants / Q000382:microbiology*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry; D014640:Vancomycin / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D011092:Polyethylene Glycols; D014640:Vancomycin; D014025:Titanium