title: Genome-association analysis of Korean Holstein milk traits using genomic estimated breeding value.
abstract: OBJECTIVE
  Holsteins are known as the world's highest-milk producing dairy cattle. The purpose of this study was to identify genetic regions strongly associated with milk traits (milk production, fat, and protein) using Korean Holstein data.
  
  
  METHODS
  This study was performed using single nucleotide polymorphism (SNP) chip data (Illumina BovineSNP50 Beadchip) of 911 Korean Holstein individuals. We inferred each genomic estimated breeding values based on best linear unbiased prediction (BLUP) and ridge regression using BLUPF90 and R. We then performed a genome-wide association study and identified genetic regions related to milk traits.
  
  
  RESULTS
  We identified 9, 6, and 17 significant genetic regions related to milk production, fat and protein, respectively. These genes are newly reported in the genetic association with milk traits of Holstein.
  
  
  CONCLUSIONS
  This study complements a recent Holstein genome-wide association studies that identified other SNPs and genes as the most significant variants. These results will help to expand the knowledge of the polygenic nature of milk production in Holsteins.
authors.affiliation: Department of Agricultural Biotechnology, Animal Biotechnology, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea.
authors.forename: Donghyun
authors.initials: D
authors.lastname: Shin
authors.affiliation: Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 151-921, Korea.
authors.forename: Chul
authors.initials: C
authors.lastname: Lee
authors.affiliation: The Animal Molecular Genetics & Breeding Center, Chonbuk National University, Jeonju 561-756, Korea.
authors.forename: Kyoung-Do
authors.initials: KD
authors.lastname: Park
authors.affiliation: Department of Agricultural Biotechnology, Animal Biotechnology, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea.|Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 151-921, Korea.
authors.forename: Heebal
authors.initials: H
authors.lastname: Kim
authors.affiliation: Division of Animal Breeding and Genetics, National Institute of Animal Science, Rural Development Administration, Cheonan 331-801, Korea.
authors.forename: Kwang-Hyeon
authors.initials: KH
authors.lastname: Cho
keywords: Genome-wide Association Studies (GWAS); Korean Holstein; Milk Fat; Milk Production; Milk Protein