title: Impact of two rounds of praziquantel mass drug administration on Schistosoma mansoni infection prevalence and intensity: a comparison between community wide treatment and school based treatment in western Kenya.
abstract: This study compared the effectiveness of the community-wide treatment and school-based treatment approaches in the control of Schistosoma mansoni infections in villages with ⩾25% prevalence in western Kenya. Stool samples from first year students, 9-12year olds and adults (20-55years) were analyzed by the Kato-Katz technique for S. mansoni eggs. After two rounds of treatment, S. mansoni prevalence and intensity levels significantly declined in both treatment approaches. Prevalence comparisons between the two approaches did not show any significant differences following treatment. However, infection intensity levels in the 9-12year old school-attending pupils were significantly higher in the community-wide treatment arm than in the school-based treatment arm. Nevertheless, significant reductions in S. mansoni infection prevalence and intensity levels were achieved among school-age children regardless of the treatment approach used.
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, P.O. Box 1578-40100, Kisumu, Kenya.
authors.forename: Isaac O
authors.initials: IO
authors.lastname: Onkanga
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, P.O. Box 1578-40100, Kisumu, Kenya.
authors.forename: Pauline N M
authors.initials: PN
authors.lastname: Mwinzi
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, P.O. Box 1578-40100, Kisumu, Kenya.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Muchiri
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, P.O. Box 1578-40100, Kisumu, Kenya.
authors.forename: Kennedy
authors.initials: K
authors.lastname: Andiego
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, P.O. Box 1578-40100, Kisumu, Kenya.
authors.forename: Martin
authors.initials: M
authors.lastname: Omedo
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, P.O. Box 1578-40100, Kisumu, Kenya.
authors.forename: Diana M S
authors.initials: DM
authors.lastname: Karanja
authors.affiliation: Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, 1600 Clifton Rd, N.E., Atlanta, GA 30329, USA.
authors.forename: Ryan E
authors.initials: RE
authors.lastname: Wiegand
authors.affiliation: Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, 1600 Clifton Rd, N.E., Atlanta, GA 30329, USA. Electronic address: was4@cdc.gov.
authors.forename: W Evan
authors.initials: WE
authors.lastname: Secor
authors.affiliation: Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, 1600 Clifton Rd, N.E., Atlanta, GA 30329, USA.
authors.forename: Susan P
authors.initials: SP
authors.lastname: Montgomery
mesh_terms: D000293:Adolescent; D000328:Adult; D000871:Anthelmintics / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003695:Delivery of Health Care; D005243:Feces / Q000469:parasitology; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008875:Middle Aged; D010270:Parasite Egg Count; D011223:Praziquantel / Q000008:administration & dosage*; D015995:Prevalence; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D012572:School Health Services; D055815:Young Adult
chemical_list: D000871:Anthelmintics; D011223:Praziquantel
keywords: Community wide treatment; Mass drug administration; Praziquantel; Prevalence; Schistosoma mansoni; Schistosomiasis; School based treatment