title: Potential Therapeutic Agents Against Retinal Diseases Caused by Aberrant Metabolism of Retinoids.
abstract: The retinoid (visual) cycle is a complex enzymatic pathway that operates in the retina for the regeneration of 11-cis-retinal (11-cis-Ral), the inherent visual chromophore indispensable for vision. Deficiencies in the retinoid metabolism are involved in pathologic mechanisms of several forms of retinal diseases including age-related macular degeneration, Stargardt's disease, and Leber's congenital amaurosis, for which no effective cures presently exist. Nevertheless, the interference of abnormal retinoid metabolism with chemicals has been considered to be a promising strategy aimed at alleviating these retinal dysfunctions. Moreover, since gene therapy is gaining increasing importance in clinical practice, the modulation of key enzymes implicated with the retinoid cycle at a genetic level will hold great promise for the treatment of patients with degenerative diseases of the retina.
authors.affiliation: Eye Center of the Second Affiliated Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang Province, China.
authors.forename: Jingmeng
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Taizhou First People's Hospital, Taizhou, Zhejiang Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Eye Center of the Second Affiliated Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Yao
authors.affiliation: Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian Province, China.
authors.forename: Yalin
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D012160:Retina / Q000378:metabolism*; D012164:Retinal Diseases / Q000139:chemically induced / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D012176:Retinoids / Q000009:adverse effects / Q000378:metabolism* / Q000493:pharmacokinetics
chemical_list: D012176:Retinoids