title: Post splenectomy related pulmonary hypertension.
abstract: Splenectomy predisposes patients to a slew of infectious and non-infectious complications including pulmonary vascular disease. Patients are at increased risk for venous thromboembolic events due to various mechanisms that may lead to chronic thromboembolic pulmonary hypertension (CTEPH). The development of CTEPH and pulmonary vasculopathy after splenectomy involves complex pathophysiologic mechanisms, some of which remain unclear. This review attempts congregate the current evidence behind our understanding about the etio-pathogenesis of pulmonary vascular disease related to splenectomy and highlight the controversies that surround its management.
authors.affiliation: Department of Pulmonary, Critical Care and Sleep Medicine, North Shore - LIJ Health System, New York, NY 11040, United States.
authors.forename: Atul V
authors.initials: AV
authors.lastname: Palkar
authors.affiliation: Department of Medicine, Monmouth Medical Center, Long Branch, NJ 07740, United States.
authors.forename: Abhinav
authors.initials: A
authors.lastname: Agrawal
authors.affiliation: Department of Pulmonary, Critical Care and Sleep Medicine, North Shore - LIJ Health System, New York, NY 11040, United States.
authors.forename: Sameer
authors.initials: S
authors.lastname: Verma
authors.affiliation: Department of Pulmonary, Critical Care and Sleep Medicine, North Shore - LIJ Health System, New York, NY 11040, United States.
authors.forename: Asma
authors.initials: A
authors.lastname: Iftikhar
authors.affiliation: Department of Pulmonary, Critical Care and Sleep Medicine, North Shore - LIJ Health System, New York, NY 11040, United States.
authors.forename: Edmund J
authors.initials: EJ
authors.lastname: Miller
authors.affiliation: Department of Pulmonary, Critical Care and Sleep Medicine, North Shore - LIJ Health System, New York, NY 11040, United States.
authors.forename: Arunabh
authors.initials: A
authors.lastname: Talwar
keywords: Chronic thromboembolic pulmonary hypertension; Pulmonary hypertension; Splenectomy; Thalassemia; Thrombocytosis