title: A model of dopamine regulation of glutamatergic synapse on medium size spiny neurons.
abstract: Spiny neurons of striatum receive glutamatergic synapses on dendritic spines on the neck of which project dopaminergic synapses. Dopamine modulates, by D1 type receptors, the glutamatergic synapses by inducing the phosphorylation of AMPA and NMDA receptors which produces an increased amplitude response. Herein we present a model where, in addition to phosphorylation, the direct modulation by dopamine of the spine resistance can cooperate in producing the observed effect on some of these synapses.
authors.affiliation: Istituto di Scienze Applicate e Sistemi Intelligenti del CNR, Italy. Electronic address: vito.dimaio@cnr.it.
authors.forename: Vito
authors.initials: V
authors.lastname: Di Maio
authors.affiliation: Istituto di Scienze Applicate e Sistemi Intelligenti del CNR, Italy. Electronic address: francescoventriglia02@gmail.com.
authors.forename: Francesco
authors.initials: F
authors.lastname: Ventriglia
authors.affiliation: Istituto di Scienze Applicate e Sistemi Intelligenti del CNR, Italy. Electronic address: s.santillo@isasi.cnr.it.
authors.forename: Silvia
authors.initials: S
authors.lastname: Santillo
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D049229:Dendritic Spines / Q000378:metabolism / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation; D018091:Receptors, AMPA / Q000378:metabolism; D017447:Receptors, Dopamine D1 / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D013569:Synapses / Q000378:metabolism / Q000502:physiology*
chemical_list: D018091:Receptors, AMPA; D017447:Receptors, Dopamine D1; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D004298:Dopamine
keywords: AMPA; Dopamine regulation; EPSC; EPSP; Glutamatergic synapse; NMDA; Synaptic model