title: Postoperative renormalization of C-reactive protein with adjuvant lienal polypeptide and its association with tumour recurrence in T1 clear cell renal cell carcinoma.
abstract: OBJECTIVE
  To evaluate the effect of pre- and postoperative C-reactive protein (CRP) levels on tumour recurrence following curative nephrectomy in patients with stage T1 clear cell renal cell carcinoma (CCRCC).
  
  
  METHODS
  Patients with stage T1 CCRCC were recruited. CRP was quantified 3 days before and 4 weeks after surgery. Patients were followed-up for clinical outcome every 3 months. A subset of patients received lienal polypeptide as adjuvant treatment.
  
  
  RESULTS
  Patients with elevated preoperative CRP levels (≥8.2 mg/l; n = 61) had higher grade tumours, were more likely to require radical nephrectomy and were more likely to experience recurrence than those with normal CRP levels. Non-normalization of elevated preoperative CRP was associated with tumour recurrence, but elevated CRP was not an independent risk factor of tumour recurrence.
  
  
  CONCLUSIONS
  Postoperative renormalization of elevated CRP is associated with decreased risk of recurrence in CCRCC.
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, Shanghai, China Fudan Institute of Urology, Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, Shanghai, China Fudan Institute of Urology, Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, Shanghai, China Fudan Institute of Urology, Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Chuanyu
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, Shanghai, China Fudan Institute of Urology, Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Gu
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, Shanghai, China Fudan Institute of Urology, Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, Shanghai, China Fudan Institute of Urology, Huashan Hospital of Fudan University, Shanghai, China drxiaguowei@163.com.
authors.forename: Guowei
authors.initials: G
authors.lastname: Xia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000601:surgery*; D003710:Demography; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010455:Peptides / Q000627:therapeutic use*; D011182:Postoperative Care; D016016:Proportional Hazards Models
chemical_list: D010455:Peptides; D002097:C-Reactive Protein
keywords: C-reactive protein; Clear cell renal cell carcinoma; recurrence