title: Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy.
abstract: Exosomes are a class of naturally occurring nanoparticles that are secreted endogenously by mammalian cells. Clinical applications for exosomes remain a challenge because of their unsuitable donors, low scalability, and insufficient targeting ability. In this study, we developed a dual-functional exosome-based superparamagnetic nanoparticle cluster as a targeted drug delivery vehicle for cancer therapy. The resulting exosome-based drug delivery vehicle exhibits superparamagnetic behavior at room temperature, with a stronger response to an external magnetic field than individual superparamagnetic nanoparticles. These properties enable exosomes to be separated from the blood and to target diseased cells. In vivo studies using murine hepatoma 22 subcutaneous cancer cells showed that drug-loaded exosome-based vehicle delivery enhanced cancer targeting under an external magnetic field and suppressed tumor growth. Our developments overcome major barriers to the utility of exosomes for cancer application.
authors.affiliation: Tianjin Key Laboratory of Composite and Functional Materials, School of Material Science and Engineering, Tianjin University , Tianjin 300072, China.
authors.forename: Hongzhao
authors.initials: H
authors.lastname: Qi
authors.affiliation: Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Department of Neurosurgery, Tianjin Medical University General Hospital and Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government , Tianjin 300052, China.
authors.forename: Chaoyong
authors.initials: C
authors.lastname: Liu
authors.affiliation: Tianjin Key Laboratory of Composite and Functional Materials, School of Material Science and Engineering, Tianjin University , Tianjin 300072, China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Long
authors.affiliation: Tianjin Research Center of Basic Medical Science, Tianjin Medical University , Tianjin 300070, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Tianjin Key Laboratory of Composite and Functional Materials, School of Material Science and Engineering, Tianjin University , Tianjin 300072, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory of Composite and Functional Materials, School of Material Science and Engineering, Tianjin University , Tianjin 300072, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Chang
authors.affiliation: Tianjin Key Laboratory of Composite and Functional Materials, School of Material Science and Engineering, Tianjin University , Tianjin 300072, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Qian
authors.affiliation: Tianjin Research Center of Basic Medical Science, Tianjin Medical University , Tianjin 300070, China.
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Jia
authors.affiliation: Tianjin Key Laboratory of Composite and Functional Materials, School of Material Science and Engineering, Tianjin University , Tianjin 300072, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Surgery, Second Hospital of Tianjin Medical University , Tianjin 300211, China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Sun
authors.affiliation: Tianjin Key Laboratory of Composite and Functional Materials, School of Material Science and Engineering, Tianjin University , Tianjin 300072, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Hou
authors.affiliation: Tianjin Key Laboratory of Composite and Functional Materials, School of Material Science and Engineering, Tianjin University , Tianjin 300072, China.
authors.forename: Xubo
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Department of Neurosurgery, Tianjin Medical University General Hospital and Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government , Tianjin 300052, China.
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Kang
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D055354:Exosomes / Q000737:chemistry*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D060526:Magnetic Fields; D059346:Magnets / Q000737:chemistry*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin
keywords: cancer targeting; drug delivery; exosome; scalable separation; superparamagnetic nanoparticle clusters