title: Functional polymorphism of the myeloperoxidase gene (G-463A) in depressive patients.
abstract: Gałecki P, Florkowski A, Bobińska K, Śmigielski J, Bieńkiewicz M, Szemraj J. Functional polymorphism of the myeloperoxidase gene (G-463A) in depressive patients.
  
  
  OBJECTIVE
  Myeloperoxidase (MPO) is an enzyme involved in the production of hypochloric acid as well as other reactive oxygen species. This enzyme plays a significant role in inflammatory processes. In view of the observed associations between depression and such inflammatory processes, as well as of the reports that confirm the presence of oxidative stress in depression, this study was designed to assess the correlation, if any, between the single nucleotide polymorphism G-463A of the MPO gene and the risk of recurrent depressive disorders (DD).
  
  
  METHODS
  The study was carried out in a group of 149 patients with recurrent DD and 149 healthy control subjects. Genotyping was performed by PCR/restriction fragment length polymorphism.
  
  
  RESULTS
  A comparison between healthy controls and depressive patients showed a statistically significant difference in genotype distribution and allele frequency in the studied groups. Genotype distribution and allele frequency did not correlate with clinical variables of the patients.
  
  
  CONCLUSIONS
  The obtained results of the study allow us to draw a cautious conclusion about the role of the analysed G-463A MPO polymorphism in recurrent DD development, which, however, requires eventual confirmation in further studies.
authors.affiliation: 1Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Gałecki
authors.affiliation: 1Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland.
authors.forename: Antoni
authors.initials: A
authors.lastname: Florkowski
authors.affiliation: 1Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland.
authors.forename: Kinga
authors.initials: K
authors.lastname: Bobińska
authors.affiliation: 2Department of Informatics and Medical Statistics, Medical University of Lodz, Lodz, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Śmigielski
authors.affiliation: 3Department of Quality Control and Radiological Protection, Medical University of Lodz, Lodz, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Bieńkiewicz
authors.affiliation: 4Department of Medical Biochemistry, Medical University of Lodz, Lodz, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Szemraj