title: Relationship between G1287A of the NET Gene Polymorphisms and Brain Volume in Major Depressive Disorder: A Voxel-Based MRI Study.
abstract: BACKGROUND
  Earlier studies implicated norepinephrine transporter (NET) gene (SLC6A2) polymorphisms in the etiology of major depressive disorder (MDD). Recently, two single nucleotide SLC6A2 polymorphisms, G1287A in exon 9 and T-182C in the promoter region, were found to be associated with MDD in different populations. We investigated the relationship between the brain volume and these two polymorphisms of the SLC6A2 in MDD patients.
  
  
  METHODS
  We obtained 3D high-resolution T1-weighted images of 30 first-episode MDD patients and 48 age- and sex-matched healthy subjects (HS). All were divided into 4 groups based on polymorphism of either the G1287A or the T-182C genotype. VBM analysis examined the effects of diagnosis, genotype, and genotype-diagnosis interactions.
  
  
  RESULTS
  Diagnosis effects on the brain morphology were found in the left superior temporal cortex. No significant genotype effects were found in the T-182C and the G1287A. A significant genotype (G1287A)-diagnosis interaction was found in the left dorsolateral prefrontal cortex. No significant genotype (T-182C)-diagnosis interaction effects were observed in any brain region.
  
  
  CONCLUSIONS
  In MDD patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Issei
authors.initials: I
authors.lastname: Ueda
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kakeda
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.affiliation: Department of Psychiatry, Fujita Health University, School of Medicine, Toyoake, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Kishi
authors.affiliation: Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Abe
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Ide
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Moriya
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Asuka
authors.initials: A
authors.lastname: Katsuki
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Hori
authors.affiliation: Department of Psychiatry, Fujita Health University, School of Medicine, Toyoake, Japan.
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Yukunori
authors.initials: Y
authors.lastname: Korogi
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D003710:Demography; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics*; D009929:Organ Size; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human