title: Effect of the consumption of β-lactoglobulin and epigallocatechin-3-gallate with or without calcium on glucose tolerance in C57BL/6 mice.
abstract: Interactions between β-lactoglobulin (β-lg) and epigallocatechin-3-gallate (EGCG) may modulate their health benefits. The objective of this study was therefore to investigate the synergistic effect of consuming β-lg and EGCG complexes on glucose tolerance of C57BL/6 male mice given an oral glucose tolerance test (OGTT) and randomized to one of the following treatments administered prior to the OGTT: 1) simulated milk ultrafiltrate (SMUF(-)), 2) SMUF(-) + EGCG, 3) SMUF(-) + β-lg, 4) SMUF(-) + EGCG + β-lg, 5) SMUF + calcium (SMUF(+)) and 6) SMUF(+) + EGCG + β-lg. We found no significant between-group difference in postprandial glucose response. However, when mice were separated in those who received β-lg from those who did not, we found that the latter displayed significantly higher postprandial glucose concentrations. Our results support the beneficial impact of β-lg on glycemic control and suggest that concomitant EGCG or calcium consumption does not improve this effect.
authors.affiliation: a Dairy Science and Technology Research Centre (STELA), Université Laval, 2425 rue de l'Agriculture , Québec , Canada ;|b Institute of Nutrition and Functional Foods (INAF), Université Laval, 2440 boulevard Hochelaga , Québec , Canada ;|c Department of Food Science , Université Laval, 2425 rue de l'Agriculture , Québec , Canada ;
authors.forename: Valérie
authors.initials: V
authors.lastname: Carnovale
authors.affiliation: b Institute of Nutrition and Functional Foods (INAF), Université Laval, 2440 boulevard Hochelaga , Québec , Canada ;|d Québec Heart and Lung Institute Research Center , 2725 chemin Ste-Foy , Québec , Canada ;
authors.forename: Geneviève
authors.initials: G
authors.lastname: Pilon
authors.affiliation: a Dairy Science and Technology Research Centre (STELA), Université Laval, 2425 rue de l'Agriculture , Québec , Canada ;|b Institute of Nutrition and Functional Foods (INAF), Université Laval, 2440 boulevard Hochelaga , Québec , Canada ;|e Agriculture and Agri-Food Canada , Food Research and Development Centre , Saint-Hyacinthe (Québec) , Canada .
authors.forename: Michel
authors.initials: M
authors.lastname: Britten
authors.affiliation: a Dairy Science and Technology Research Centre (STELA), Université Laval, 2425 rue de l'Agriculture , Québec , Canada ;|b Institute of Nutrition and Functional Foods (INAF), Université Laval, 2440 boulevard Hochelaga , Québec , Canada ;|c Department of Food Science , Université Laval, 2425 rue de l'Agriculture , Québec , Canada ;
authors.forename: Laurent
authors.initials: L
authors.lastname: Bazinet
authors.affiliation: b Institute of Nutrition and Functional Foods (INAF), Université Laval, 2440 boulevard Hochelaga , Québec , Canada ;|f School of Nutrition , Université Laval, 2425 rue de l'Agriculture , Québec , Canada.
authors.forename: Charles
authors.initials: C
authors.lastname: Couillard
mesh_terms: D000818:Animals; D001786:Blood Glucose; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology*; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005947:Glucose / Q000008:administration & dosage* / Q000378:metabolism; D018149:Glucose Intolerance / Q000517:prevention & control*; D007782:Lactoglobulins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011897:Random Allocation
chemical_list: D001786:Blood Glucose; D007782:Lactoglobulins; D002392:Catechin; C045651:epigallocatechin gallate; D005947:Glucose; D002118:Calcium
keywords: Catechin; incretins; insulin; whey proteins