title: Lutetium(III) acetate phthalocyanines for photodynamic therapy applications: Synthesis and photophysicochemical properties.
abstract: BACKGROUND
  The development of new water-soluble photosensitizers for photodynamic therapy (PDT) applications is a very active research topic. Efforts have been made to obtain the far-red absorbing phthalocyanine complexes with molecular design that facilitates the uptake and selectivity for a high PDT efficiency.
  
  
  METHODS
  The monomolecular lutetium(III) acetate phthalocyanines (LuPcs) substituted with methylpyridyloxy groups at non-peripheral (5) and peripheral (6) positions were synthesized by following the modification of the well-known synthetical routes. The photo-physicochemical properties of the both quaternized LuPcs were evaluated by the steady-state and time-resolved spectroscopy. The photochemical technique was applied to study the generation of the singlet oxygen.
  
  
  RESULTS
  Two water-soluble and cationic LuPcs were synthesized and chemically characterized. The photo-physicochemical properties of absorption (675 and 685nm) and the red shifted fluorescence (704 and 721nm) as well as the fluorescence lifetimes (2.24 and 3.27ns) were studied. The promising values of singlet oxygen quantum yields (0.32 for 5 and 0.35 for 6) were determined.
  
  
  CONCLUSIONS
  Lutetium(III) acetate phthalocyanine complexes were synthesized and evaluated with physicochemical properties suitable for future photodynamic therapy applications.
authors.affiliation: Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str., Bld. 9, 1113 Sofia, Bulgaria. Electronic address: mantareva@yahoo.com.
authors.forename: Vanya
authors.initials: V
authors.lastname: Mantareva
authors.affiliation: Gebze Technical University, Department of Chemistry, P. O. Box 141, Gebze-Kocaeli 41400, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Durmuş
authors.affiliation: Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str., Bld. 9, 1113 Sofia, Bulgaria; Gebze Technical University, Department of Chemistry, P. O. Box 141, Gebze-Kocaeli 41400, Turkey.
authors.forename: Meliha
authors.initials: M
authors.lastname: Aliosman
authors.affiliation: Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str., Bld. 9, 1113 Sofia, Bulgaria.
authors.forename: Ivanka
authors.initials: I
authors.lastname: Stoineva
authors.affiliation: Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str., Bld. 9, 1113 Sofia, Bulgaria.
authors.forename: Ivan
authors.initials: I
authors.lastname: Angelov
mesh_terms: D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D054833:Isoindoles; D008187:Lutetium / Q000737:chemistry / Q000627:therapeutic use; D015394:Molecular Structure; D010778:Photochemotherapy; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D007211:Indoles; D054833:Isoindoles; D014867:Water; D008187:Lutetium; C013647:phthalocyanine
keywords: Fluorescence; Life-time measurements; Lutetium(III) phthalocyanines; Photosensitizers; Singlet oxygen