title: Optical coherence tomography angiography in adult-onset foveomacular vitelliform dystrophy.
abstract: OBJECTIVE
  To describe structural features of eyes with adult-onset foveomacular vitelliform dystrophy (AFVD) on optical coherence tomography angiography (OCT-A) and to evaluate the ability to detect the presence of choroidal neovascularisation (CNV).
  
  
  METHODS
  Consecutive patients presenting at the University Eye Clinic of Creteil with diagnosis of AFVD were included. All patients underwent a complete ophthalmological examination, including fundus autofluorescence, fluorescein angiography, indocyanine green angiography, spectral domain optical coherence tomography and OCT-A by Optovue RTVue XR Avanti.
  
  
  RESULTS
  Twenty-two eyes of 18 consecutive patients (8 women and 10 men; 68±12.8 years) were included. On OCT-A the presence of subretinal material leads to displacement of blood vessels at both the superficial and deep capillary plexuses of the retina. In one case, these vascular abnormalities were associated with long filamentous vessels running thorough the foveal avascular area. In all cases, a rarefaction of the choriocapillaris was also observed. In two eyes OCT-A distinctly disclosed the presence of a CNV secondary to AFVD while conventional imaging did not show clearly the neovascularisation due to masking effect of the subretinal vitelliform material.
  
  
  CONCLUSIONS
  In patients with AFVD, OCT-A showed vascular network rarefaction with less blood vessels at the superficial and deep capillary plexuses, and the choriocapillaris layer. These vascular abnormalities may play a role in the pathogenesis or simply represent a consequence of material accumulation and reabsorption in AFVD. In two cases, the conventional imaging did not show clearly the neovascularisation due to masking effect of the subretinal vitelliform material, while OCT-A showed distinctly the CNV.
authors.affiliation: Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.|Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Querques
authors.affiliation: Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
authors.forename: Olivia
authors.initials: O
authors.lastname: Zambrowski
authors.affiliation: Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.|Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Corvi
authors.affiliation: Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Miere
authors.affiliation: Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
authors.forename: Oudy
authors.initials: O
authors.lastname: Semoun
authors.affiliation: Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
authors.forename: Mayer
authors.initials: M
authors.lastname: Srour
authors.affiliation: Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
authors.forename: Eric H
authors.initials: EH
authors.lastname: Souied
mesh_terms: D000368:Aged; D002829:Choroid / Q000473:pathology*; D020256:Choroidal Neovascularization / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000473:pathology*; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D057826:Vitelliform Macular Dystrophy / Q000150:complications / Q000175:diagnosis*
keywords: Imaging; Macula; Retina