title: Nanomedicines for Endothelial Disorders.
abstract: The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications.
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Department of Chemical Engineering, Massachusetts Institute of Technology.
authors.forename: Bomy Lee
authors.initials: BL
authors.lastname: Chung
authors.affiliation: George W. Woodruff School of Mechanical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Institute for Electronics and Nanotechnology (IEN), Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Georgia Institute of Technology.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Toth
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Laboratory of Nanomedicine and Biomaterials, Brigham and Women's Hospital, Harvard Medical School.
authors.forename: Nazila
authors.initials: N
authors.lastname: Kamaly
authors.affiliation: George W. Woodruff School of Mechanical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Institute for Electronics and Nanotechnology (IEN), Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Georgia Institute of Technology.
authors.forename: Yoshitaka J
authors.initials: YJ
authors.lastname: Sei
authors.affiliation: Department of Biological Engineering, Massachusetts Institute of Technology.
authors.forename: Jacob
authors.initials: J
authors.lastname: Becraft
authors.affiliation: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai.
authors.forename: Willem J M
authors.initials: WJ
authors.lastname: Mulder
authors.affiliation: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai.
authors.forename: Zahi A
authors.initials: ZA
authors.lastname: Fayad
authors.affiliation: Laboratory of Nanomedicine and Biomaterials, Brigham and Women's Hospital, Harvard Medical School; King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Omid C
authors.initials: OC
authors.lastname: Farokhzad
authors.affiliation: George W. Woodruff School of Mechanical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Institute for Electronics and Nanotechnology (IEN), Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Georgia Institute of Technology.
authors.forename: YongTae
authors.initials: Y
authors.lastname: Kim
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Department of Chemical Engineering, Massachusetts Institute of Technology; Department of Biological Engineering, Massachusetts Institute of Technology; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology.
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
keywords: atherosclerosis; cancer; diabetes; endothelial disorder; endothelium; nanomedicine; permeability