title: Development and Validation of the Rappel Indicé-24: Behavioral and Brain Morphological Evidence.
abstract: The primary goals of the present study were to develop and validate the Rappel Indicé 24 (RI-24), a shorter version of the original Rappel Indicé, which includes 48 items (RI-48), and to identify the specific brain regions that were correlated with scores on the RI-24. Using these clinical scales, the present study evaluated 91 elderly Korean participants who were classified into 3 groups: normal control (NC; n = 34), patients with mild cognitive impairment (MCI; n = 29), and patients with Alzheimer disease (AD; n = 28). Of the 91 participants, 77 also underwent magnetic resonance imaging scans. The RI-24 delayed cued recall (DCR) scores significantly differed among the NC, MCI, and AD groups. A receiver-operating characteristic curve analysis revealed that the RI-24 was very sensitive (89%) and specific (91%) for the detection of AD. Furthermore, although the time needed to administer the RI-24 was half that needed for the RI-48, the 24-item version showed a high correlation (r= .85 for the DCR score) with the 48-item version. In terms of brain morphological characteristics, voxel-based morphometry analyses revealed a significant positive correlation between DCR score and gray matter volume in the parahippocampal gyrus (r= .468), which plays a role in cued recall. Taken together, the present findings indicate that the RI-24 is a sensitive and reliable test for the detection of memory impairments in patients with MCI and AD despite its brief administration time.
authors.affiliation: Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine and SMG-SNU Boramae Medical Center, Seoul, Korea Department of Education, Seoul National University, Seoul, Korea.
authors.forename: Soowon
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine and SMG-SNU Boramae Medical Center, Seoul, Korea.
authors.forename: Inhye
authors.initials: I
authors.lastname: Kim
authors.affiliation: University of California Santa Cruz, Santa Cruz, CA, USA.
authors.forename: Hyun Gyu
authors.initials: HG
authors.lastname: Park
authors.affiliation: Department of Biomedical Sciences, Seoul National University, Seoul, Korea.
authors.forename: Seong A
authors.initials: SA
authors.lastname: Shin
authors.affiliation: Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine and SMG-SNU Boramae Medical Center, Seoul, Korea.
authors.forename: Youngsung
authors.initials: Y
authors.lastname: Cho
authors.affiliation: Yongmoon Graduate School of Counseling Psychology, Seoul, Korea.
authors.forename: Jung-Hae
authors.initials: JH
authors.lastname: Youn
authors.affiliation: Department of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea.
authors.forename: Yu Kyeong
authors.initials: YK
authors.lastname: Kim
authors.affiliation: Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine and SMG-SNU Boramae Medical Center, Seoul, Korea benji@snu.ac.kr.
authors.forename: Jun-Young
authors.initials: JY
authors.lastname: Lee
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology* / Q000523:psychology*; D044466:Asian People; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D060825:Cognitive Dysfunction / Q000150:complications / Q000473:pathology* / Q000523:psychology*; D003463:Cues; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D011939:Mental Recall; D009483:Neuropsychological Tests; D012372:ROC Curve; D056910:Republic of Korea
keywords: Alzheimer disease; Rappel indicé-48; cued recall; mild cognitive impairment