title: Incidence, epidemiology and clinical features of Kawasaki disease in Catalonia, Spain.
abstract: OBJECTIVE
  To assess the incidence, epidemiology and clinical features of Kawasaki disease (KD) in Catalonia (northeast region of Spain).
  
  
  METHODS
  This was an observational population-based study including all Paediatric Units in Catalonia, under both public and private management. Retrospective data retrieval was performed for 10 years (2004-2013). A 12-month (March 2013 to March 2014) prospective collection of new cases of KD was carried out to determine the incidence of KD.
  
  
  RESULTS
  Data from 399 patients over the 10-year study period was analysed, revealing that 233 (58.4%) had complete KD, 159 (39.8) incomplete KD and 7 (1.7%) were considered atypical KD. Mean annual incidence was 3.5/105 children <14 years old (yo) and 8/105 children <5 yo (mean age 37±33 months, range 1.3-191.3). KD was more frequent in boys (59.6%, p<0.001) and in rural areas (p<0.001). Patients with IVIG non-responsiveness, need of a 2(nd) IVIG dose, delay of treatment >10(th) day of illness, ages <1 yo and >8 yo and the presence of sterile piuria, aseptic meningitis, abdominal pain and uveitis at diagnosis were found to have higher risk of coronary aneurisms (CAA) (p<0.05).
  
  
  CONCLUSIONS
  This is the first population-based study on the epidemiology of KD in the western Mediterranean area. Incidence, clinical features and treatment plans in our cohort are similar to those described in other European studies.
authors.affiliation: Unitat de Reumatologia Pediàtrica, Servei de Pediatria, Hospital Universitari Parc Taulí, Sabadell, Barcelona; and Unitat de Reumatologia Pediàtrica, Servei de Pediatria, Hosp. Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain. jsanchez@tauli.cat.
authors.forename: Judith
authors.initials: J
authors.lastname: Sánchez-Manubens
authors.affiliation: Unitat de Reumatologia Pediàtrica, Servei de Pediatria, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Antón
authors.affiliation: Unitat de Reumatologia Pediàtrica, Servei de Pediatria, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Bou
authors.affiliation: Unitat de Reumatologia Pediàtrica, Servei de Pediatria, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
authors.forename: Estíbaliz
authors.initials: E
authors.lastname: Iglesias
authors.affiliation: Unitat de Reumatologia Pediàtrica, Servei de Pediatria, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Calzada-Hernandez
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000453:epidemiology*; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology