title: [Tumorigenesis: interplay of pattern recognition receptors and autophagy].
abstract: According to recent data, the involvement of autophagy in tumor development is unquestionable. Nevertheless, cell-derived pathogen/danger-associated molecular pattern (PAMP/DAMP)-sensing Toll-like receptors (TLRs) are also able to contribute to tumorigenesis and immune escape of malignantly transformed cells. Besides immunocompetent cells, several types of tumors also exhibit TLRs. TLR- and autophagy-related signaling pathways, on the other hand, may evolve anti-tumor effects in a context dependent cell- and microenvironment-specific mode. Nowadays, the autophagy machinery has been considered as a crucial homeostatic process of eukaryotic cells, and as essential constituent of the immune system influencing antimicrobial and inflammation-related immune responses. Accumulating evidence indicates that TLRs and autophagy are interdependent in response to PAMPs and DAMPs, in addition there is a bi-directional controling cross-modulation between them. Regarding personalized medicine, theoretically, it is reasonable that manipulation of the TLR-autophagy regulatory loop might be adaptable for anti-cancer therapy.
authors.affiliation: II. Sz. Belgyógyászati Klinika, Semmelweis Egyetem, Budapest, Hungary. muzes.gyorgyi@med.semmelweis-univ.hu.
authors.forename: Györgyi
authors.initials: G
authors.lastname: Mûzes
authors.affiliation: II. Sz. Belgyógyászati Klinika, Semmelweis Egyetem, Budapest, Hungary. muzes.gyorgyi@med.semmelweis-univ.hu.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Sipos
mesh_terms: D001343:Autophagy; D063646:Carcinogenesis; D002468:Cell Physiological Phenomena; D002471:Cell Transformation, Neoplastic; D006801:Humans; D007113:Immunity, Innate; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology*; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors / Q000378:metabolism*
chemical_list: D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors