title: The impact of common polymorphisms in CETP and ABCA1 genes with the risk of coronary artery disease in Saudi Arabians.
abstract: BACKGROUND
  Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Many genetic and environmental risk factors including atherogenic dyslipidemia contribute towards the development of CAD. Functionally relevant mutations in the dyslipidemia-related genes and enzymes involved in the reverse cholesterol transport system are associated with CAD and contribute to increased susceptibility of myocardial infarction (MI).
  
  
  METHODS
  Blood samples from 990 angiographically confirmed Saudi CAD patients with at least one event of myocardial infarction were collected between 2012 and 2014. A total of 618 Saudi controls with no history or family history of CAD participated in the study. Four polymorphisms, rs2230806, rs2066715 (ABCA1), rs5882, and rs708272 (CETP), were genotyped using TaqMan Assay.
  
  
  RESULTS
  CETP rs5882 (OR = 1.45, P < 0.005) and ABCA1 rs2230806 (OR = 1.42, P = 0.017) polymorphisms were associated with increased risk of CAD. However, rs708272 polymorphism showed protective effect (B1 vs. B2: OR = 0.80, P = 0.003 and B2B2 vs. B1B1: OR = 0.68, P = 0.012) while the ABCA1 variant rs2066715 was not associated.
  
  
  CONCLUSIONS
  This study is the first to report the association of these polymorphisms with CAD in the population of the Eastern Province of Saudi Arabia. The rs5882 polymorphism (CETP) showed a significant association and therefore could be a promising marker for CAD risk estimation while the rs708272 polymorphism had a protective effect from CAD.
authors.affiliation: Institute for Research and Medical Consultation, University of Dammam, P.O.Box 1982, Dammam, 31441, Kingdom of Saudi Arabia. ccyrus@uod.edu.sa.
authors.forename: Cyril
authors.initials: C
authors.lastname: Cyrus
authors.affiliation: Institute for Research and Medical Consultation, University of Dammam, P.O.Box 1982, Dammam, 31441, Kingdom of Saudi Arabia.
authors.forename: Chittibabu
authors.initials: C
authors.lastname: Vatte
authors.affiliation: King Fahd Hospital of the University, University of Dammam, P.O.Box 4001, Al-Khobar, 31952, Kingdom of Saudi Arabia.
authors.forename: Awatif
authors.initials: A
authors.lastname: Al-Nafie
authors.affiliation: Institute for Research and Medical Consultation, University of Dammam, P.O.Box 1982, Dammam, 31441, Kingdom of Saudi Arabia.
authors.forename: Shahanas
authors.initials: S
authors.lastname: Chathoth
authors.affiliation: King Fahd Hospital of the University, University of Dammam, P.O.Box 4001, Al-Khobar, 31952, Kingdom of Saudi Arabia.
authors.forename: Rudaynah
authors.initials: R
authors.lastname: Al-Ali
authors.affiliation: King Fahd Hospital of the University, University of Dammam, P.O.Box 4001, Al-Khobar, 31952, Kingdom of Saudi Arabia.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Al-Shehri
authors.affiliation: King Fahd Hospital of the University, University of Dammam, P.O.Box 4001, Al-Khobar, 31952, Kingdom of Saudi Arabia.
authors.forename: Mohammed Shakil
authors.initials: MS
authors.lastname: Akhtar
authors.affiliation: King Fahd Hospital of the University, University of Dammam, P.O.Box 4001, Al-Khobar, 31952, Kingdom of Saudi Arabia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Almansori
authors.affiliation: King Fahd Hospital of the University, University of Dammam, P.O.Box 4001, Al-Khobar, 31952, Kingdom of Saudi Arabia.
authors.forename: Fahad
authors.initials: F
authors.lastname: Al-Muhanna
authors.affiliation: Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Brendan
authors.initials: B
authors.lastname: Keating
authors.affiliation: Institute for Research and Medical Consultation, University of Dammam, P.O.Box 1982, Dammam, 31441, Kingdom of Saudi Arabia.
authors.forename: Amein
authors.initials: A
authors.lastname: Al-Ali
mesh_terms: D064286:ATP Binding Cassette Transporter 1 / Q000235:genetics*; D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000235:genetics; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics* / Q000473:pathology; D050171:Dyslipidemias / Q000235:genetics / Q000473:pathology; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012529:Saudi Arabia
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins