title: Modified Polyacrylic Acid-Zinc Composites: Synthesis, Characterization and Biological Activity.
abstract: Polyacrylic acid (PAA) is an important industrial chemical, which has been extensively applied in various fields, including for several biomedical purposes. In this study, we report the synthesis and modification of this polymer with various phenol imides, such as succinimide, phthalimide and 1,8-naphthalimide. The as-synthesized derivatives were used to prepare polymer metal composites by the reaction with Zn(+2). These composites were characterized by using various techniques, including NMR, FT-IR, TGA, SEM and DSC. The as-prepared PAA-based composites were further evaluated for their anti-microbial properties against various pathogens, which include both Gram-positive and Gram-negative bacteria and different fungal strains. The synthesized composites have displayed considerable biocidal properties, ranging from mild to moderate activities against different strains tested.
authors.affiliation: Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. rafiskm@gmail.com.
authors.forename: Mohammed Rafi
authors.initials: MR
authors.lastname: Shaik
authors.affiliation: Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. mufsir@gmail.com.
authors.forename: Mufsir
authors.initials: M
authors.lastname: Kuniyil
authors.affiliation: Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. kmujeeb@ksu.edu.sa.
authors.forename: Mujeeb
authors.initials: M
authors.lastname: Khan
authors.affiliation: Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. exactlykot@gmail.com.
authors.forename: Naushad
authors.initials: N
authors.lastname: Ahmad
authors.affiliation: Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. awarthan@ksu.edu.sa.
authors.forename: Abdulrahman
authors.initials: A
authors.lastname: Al-Warthan
authors.affiliation: Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. rafiqs@ksu.edu.sa.
authors.forename: Mohammed Rafiq H
authors.initials: MR
authors.lastname: Siddiqui
authors.affiliation: Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. sfadil@ksu.edu.sa.
authors.forename: Syed Farooq
authors.initials: SF
authors.lastname: Adil
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003188:Composite Resins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008279:Magnetic Resonance Imaging; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D015032:Zinc / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D000890:Anti-Infective Agents; D003188:Composite Resins; C006903:carbopol 940; D015032:Zinc
keywords: biological activity; metal composite; polyacrylic acid; zinc