title: Management of Hypoparathyroidism: Summary Statement and Guidelines.
abstract: OBJECTIVE
  Hypoparathyroidism is a rare disorder characterized by hypocalcemia and absent or deficient PTH. This report presents a summary of current information about epidemiology, presentation, diagnosis, clinical features, and management and proposes guidelines to help clinicians diagnose, evaluate, and manage this disorder.
  
  
  METHODS
  Participants in the First International Conference on the Management of Hypoparathyroidism represented a worldwide constituency with acknowledged interest and expertise in key basic, translational, and clinical aspects of hypoparathyroidism. Three Workshop Panels were constituted to address questions for presentation and discussion at the Conference held in Florence, Italy, May 7-9, 2015. At that time, a series of presentations were made, followed by in-depth discussions in an open forum. Each Workshop Panel also met in closed sessions to formulate the three evidence-based reports that accompany this summary statement. An Expert Panel then considered this information, developed summaries, guidelines, and a research agenda that constitutes this summary statement.
  
  
  METHODS
  Preceding the conference, each Workshop Panel conducted an extensive literature search as noted in the individual manuscripts accompanying this report. All presentations were based upon the best peer-reviewed information taking into account the historical and current literature.
  
  
  METHODS
  This report represents the Expert Panel's synthesis of the conference material placed in a context designed to be relevant to clinicians and those engaged in cutting-edge studies of hypoparathyroidism.
  
  
  CONCLUSIONS
  This document not only provides a summary of our current knowledge but also places recent advances in its management into a context that should enhance future advances in our understanding of hypoparathyroidism.
authors.affiliation: Department of Surgery and Translational Medicine (M.L.B.), University of Florence, 50121 Florence, Italy; Columbia University College of Physicians & Surgeons (J.P.B.), New York, New York 10032; Endocrine Research Unit (D.S.), San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121; Clinic and Laboratory of Experimental Endocrinology (R.B.), Gasthuisberg, KU Leuven, 3000 Leuven, Belgium; Mayo Clinic (B.C.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Rochester, Minnesota 55905; Academic Endocrine Unit (R.V.T.), Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, United Kingdom; McMaster University Calcium Disorders Clinic (A.A.K.), Hamilton, Canada L8S4L8; and Massachusetts General Hospital (J.T.P.), Boston, Massachusetts 02114.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Brandi
authors.affiliation: Department of Surgery and Translational Medicine (M.L.B.), University of Florence, 50121 Florence, Italy; Columbia University College of Physicians & Surgeons (J.P.B.), New York, New York 10032; Endocrine Research Unit (D.S.), San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121; Clinic and Laboratory of Experimental Endocrinology (R.B.), Gasthuisberg, KU Leuven, 3000 Leuven, Belgium; Mayo Clinic (B.C.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Rochester, Minnesota 55905; Academic Endocrine Unit (R.V.T.), Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, United Kingdom; McMaster University Calcium Disorders Clinic (A.A.K.), Hamilton, Canada L8S4L8; and Massachusetts General Hospital (J.T.P.), Boston, Massachusetts 02114.
authors.forename: John P
authors.initials: JP
authors.lastname: Bilezikian
authors.affiliation: Department of Surgery and Translational Medicine (M.L.B.), University of Florence, 50121 Florence, Italy; Columbia University College of Physicians & Surgeons (J.P.B.), New York, New York 10032; Endocrine Research Unit (D.S.), San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121; Clinic and Laboratory of Experimental Endocrinology (R.B.), Gasthuisberg, KU Leuven, 3000 Leuven, Belgium; Mayo Clinic (B.C.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Rochester, Minnesota 55905; Academic Endocrine Unit (R.V.T.), Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, United Kingdom; McMaster University Calcium Disorders Clinic (A.A.K.), Hamilton, Canada L8S4L8; and Massachusetts General Hospital (J.T.P.), Boston, Massachusetts 02114.
authors.forename: Dolores
authors.initials: D
authors.lastname: Shoback
authors.affiliation: Department of Surgery and Translational Medicine (M.L.B.), University of Florence, 50121 Florence, Italy; Columbia University College of Physicians & Surgeons (J.P.B.), New York, New York 10032; Endocrine Research Unit (D.S.), San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121; Clinic and Laboratory of Experimental Endocrinology (R.B.), Gasthuisberg, KU Leuven, 3000 Leuven, Belgium; Mayo Clinic (B.C.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Rochester, Minnesota 55905; Academic Endocrine Unit (R.V.T.), Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, United Kingdom; McMaster University Calcium Disorders Clinic (A.A.K.), Hamilton, Canada L8S4L8; and Massachusetts General Hospital (J.T.P.), Boston, Massachusetts 02114.
authors.forename: Roger
authors.initials: R
authors.lastname: Bouillon
authors.affiliation: Department of Surgery and Translational Medicine (M.L.B.), University of Florence, 50121 Florence, Italy; Columbia University College of Physicians & Surgeons (J.P.B.), New York, New York 10032; Endocrine Research Unit (D.S.), San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121; Clinic and Laboratory of Experimental Endocrinology (R.B.), Gasthuisberg, KU Leuven, 3000 Leuven, Belgium; Mayo Clinic (B.C.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Rochester, Minnesota 55905; Academic Endocrine Unit (R.V.T.), Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, United Kingdom; McMaster University Calcium Disorders Clinic (A.A.K.), Hamilton, Canada L8S4L8; and Massachusetts General Hospital (J.T.P.), Boston, Massachusetts 02114.
authors.forename: Bart L
authors.initials: BL
authors.lastname: Clarke
authors.affiliation: Department of Surgery and Translational Medicine (M.L.B.), University of Florence, 50121 Florence, Italy; Columbia University College of Physicians & Surgeons (J.P.B.), New York, New York 10032; Endocrine Research Unit (D.S.), San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121; Clinic and Laboratory of Experimental Endocrinology (R.B.), Gasthuisberg, KU Leuven, 3000 Leuven, Belgium; Mayo Clinic (B.C.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Rochester, Minnesota 55905; Academic Endocrine Unit (R.V.T.), Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, United Kingdom; McMaster University Calcium Disorders Clinic (A.A.K.), Hamilton, Canada L8S4L8; and Massachusetts General Hospital (J.T.P.), Boston, Massachusetts 02114.
authors.forename: Rajesh V
authors.initials: RV
authors.lastname: Thakker
authors.affiliation: Department of Surgery and Translational Medicine (M.L.B.), University of Florence, 50121 Florence, Italy; Columbia University College of Physicians & Surgeons (J.P.B.), New York, New York 10032; Endocrine Research Unit (D.S.), San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121; Clinic and Laboratory of Experimental Endocrinology (R.B.), Gasthuisberg, KU Leuven, 3000 Leuven, Belgium; Mayo Clinic (B.C.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Rochester, Minnesota 55905; Academic Endocrine Unit (R.V.T.), Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, United Kingdom; McMaster University Calcium Disorders Clinic (A.A.K.), Hamilton, Canada L8S4L8; and Massachusetts General Hospital (J.T.P.), Boston, Massachusetts 02114.
authors.forename: Aliya A
authors.initials: AA
authors.lastname: Khan
authors.affiliation: Department of Surgery and Translational Medicine (M.L.B.), University of Florence, 50121 Florence, Italy; Columbia University College of Physicians & Surgeons (J.P.B.), New York, New York 10032; Endocrine Research Unit (D.S.), San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121; Clinic and Laboratory of Experimental Endocrinology (R.B.), Gasthuisberg, KU Leuven, 3000 Leuven, Belgium; Mayo Clinic (B.C.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Rochester, Minnesota 55905; Academic Endocrine Unit (R.V.T.), Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, United Kingdom; McMaster University Calcium Disorders Clinic (A.A.K.), Hamilton, Canada L8S4L8; and Massachusetts General Hospital (J.T.P.), Boston, Massachusetts 02114.
authors.forename: John T
authors.initials: JT
authors.lastname: Potts
mesh_terms: D019468:Disease Management; D019317:Evidence-Based Medicine; D006801:Humans; D007011:Hypoparathyroidism / Q000175:diagnosis* / Q000628:therapy*