title: An investigation into bisphenol A leaching from materials used intraorally.
abstract: In this study, the authors quantitatively determined the bisphenol A (BPA) leached from intraoral materials during simulated intraoral exposure.
  
  
  
  The authors subjected samples of intraoral materials to simulated abrasion, immersion in artificial saliva, thermal shock via temperature cycling, and simulated intraoral exposure. The authors collected sample aliquots for up to 2 weeks after artificial saliva immersion, derivatized, and then analyzed the aliquots for BPA by gas chromatography and mass spectroscopy.
  
  
  
  Quantifiable amounts of leached BPA were observed from only 1 of 13 intraoral materials tested: a silicone baby bottle nipple (20 micrograms). BPA leaching was only observed after 3 days of artificial saliva immersion, with no additional leaching thereafter.
  
  
  
  Under the test conditions, BPA was observed to leach from a silicone baby bottle nipple.
  
  
  
  Although the quantities of leached BPA were below the reference dose for daily intake, investigators have shown a possible association between low levels of BPA and many medical disorders. BPA exposure, and thus the use of the leaching material identified in this study, should be reduced or eliminated.
authors.forename: Richa
authors.initials: R
authors.lastname: Sharma
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Kotyk
authors.forename: William A
authors.initials: WA
authors.lastname: Wiltshire
mesh_terms: D001559:Benzhydryl Compounds / Q000493:pharmacokinetics*; D003764:Dental Materials / Q000737:chemistry*; D006801:Humans; D010636:Phenols / Q000493:pharmacokinetics*; D012464:Saliva, Artificial; D013696:Temperature; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D003764:Dental Materials; D010636:Phenols; D012464:Saliva, Artificial; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: BPA; Bisphenol A; intraoral materials; leaching