title: Calcium signalling in pancreatic stellate cells: Mechanisms and potential roles.
abstract: Hepatic and pancreatic stellate cells may or may not be regarded as stem cells, but they are capable of remarkable transformations. There is less information about stellate cells in the pancreas than in the liver, where they were discovered much earlier and therefore have been studied longer and more intensively than in the pancreas. Most of the work on pancreatic stellate cells has been carried out in studies on cell cultures, but in this review we focus attention on Ca(2+) signalling in stellate cells in their real pancreatic environment. We review current knowledge on patho-physiologically relevant Ca(2+) signalling events and their underlying mechanisms. We focus on the effects of bradykinin in the initial stages of acute pancreatitis, an often fatal disease in which the pancreas digests itself and its surroundings. Ca(2+) signals, elicited in the stellate cells by the action of bradykinin, may have a negative effect on the outcome of the acute disease process and promote the development of chronic pancreatitis. The bradykinin-elicited Ca(2+) signals can be inhibited by blockade of type 2 receptors and also by blockade of Ca(2+)-release activated Ca(2+) channels. The potential benefits of such pharmacological inhibition for the treatment of pancreatitis are reviewed.
authors.affiliation: Medical Research Council Group, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK; Bogomoletz Institute of Physiology, Kiev 01024, Ukraine.
authors.forename: Oleksiy
authors.initials: O
authors.lastname: Gryshchenko
authors.affiliation: Medical Research Council Group, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK.
authors.forename: Julia V
authors.initials: JV
authors.lastname: Gerasimenko
authors.affiliation: Medical Research Council Group, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK.
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Gerasimenko
authors.affiliation: Medical Research Council Group, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK. Electronic address: PetersenOH@cardiff.ac.uk.
authors.forename: Ole H
authors.initials: OH
authors.lastname: Petersen
mesh_terms: D001920:Bradykinin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000187:drug effects*; D006801:Humans; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D058954:Pancreatic Stellate Cells / Q000187:drug effects* / Q000378:metabolism; D010195:Pancreatitis / Q000188:drug therapy* / Q000378:metabolism; D044139:Receptor, Angiotensin, Type 2 / Q000378:metabolism
chemical_list: D044139:Receptor, Angiotensin, Type 2; D001920:Bradykinin; D002118:Calcium
keywords: Bradykinin; Bradykinin receptors; Calcium entry; Calcium release; Calcium signalling; Kallikrein; Kininogen