title: ANTIPARASITIC ACTIVITY OF SILVER AND COPPER OXIDE NANOPARTICLES AGAINST ENTAMOEBA HISTOLYTICA AND CRYPTOSPORIDIUM PARVUM CYSTS.
abstract: Nanoparticles (NPs) have received more attention as antiparasitic agents. In the present study, silver and copper nanoparticles were synthesized and characterized using scanning electron microscopy (SEM), transmission electron microscope (TEM) and X-ray fluorescence (XRF). The antiparasitic activity of Ag and CuO nanoparticles were tested against two of the most environmentally spread parasites in Egypt (Entamoeba histolytica and Cryptosporidium parvum). The average sizes of synthesized Ag NPs and CuO NPs were 9 & 29 nm respectively and a significant reduction for cysts viability (p > 0.05) was observed for CuO NPs against E. histolytica cysts and Ag NPs against C. parvum oocysts. Moreover, LC50-3h of CuO NPs for E. histolytica and C. parvum were 0.13 and 0.72 mg/l, while Ag NPs recorded 0.34 and 0.54 mg/l respectively. Accordingly, these NPs could be suggested as a new nanoform agent for safe and effective treatment of E. histolytica and C. parvum parasites.
authors.forename: Halim A
authors.initials: HA
authors.lastname: Saad
authors.forename: Mohamed I
authors.initials: MI
authors.lastname: Soliman
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Azzam
authors.forename: B
authors.initials: B
authors.lastname: Mostafa
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D016785:Cryptosporidium parvum / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004748:Entamoeba histolytica / Q000187:drug effects*; D005243:Feces / Q000469:parasitology; D006801:Humans; D053768:Metal Nanoparticles / Q000032:analysis*; D008855:Microscopy, Electron, Scanning; D033661:Oocysts / Q000187:drug effects; D012834:Silver / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000977:Antiparasitic Agents; D012834:Silver; D003300:Copper; C030973:cupric oxide