title: A rare complication of carcinoÏd carcinoma.
abstract: In this case report of a patient with carcinoid carcinoma we discuss the normal metabolism of tryptophan, one of the essential amino acids. We also examined the changes of this metabolism due to the metastasis of the carcinoid carcinoma and its psychiatric complications based on a central tryptophan deficiency. A less frequent complication of the changes in the tryptophan metabolism due to carcinoidosis is the disease pellagra. This disease is always accompanied with psychiatric symptoms. It plays an important role in the development of the transmethylation hypothesis of schizophrenia.
authors.affiliation: *afd. Psychiatrie van het Academisch Ziekenhuis Rotterdam-Dijkzigt.
authors.forename: W W
authors.initials: WW
authors.lastname: Broek
authors.affiliation: **biologische psychiatrie,Erasmus Universiteit Rotterdam.
authors.forename: L
authors.initials: L
authors.lastname: Pepplinkhuizen