title: The prognostic value of phosphatase and tensin homolog negativity in breast cancer: A systematic review and meta-analysis of 32 studies with 4393 patients.
abstract: The prognostic value of phosphatase and tensin homolog (PTEN) negativity in breast cancer has been evaluated by many studies but remains controversial. We conducted a meta-analysis to assess the association of PTEN negativity with overall survival and disease-free survival. Thirty-two studies with 4393 patients were identified. PTEN negativity was significantly associated with unfavorable overall survival in breast cancer (hazard ratio=1.89, 95% confidence interval 1.58-2.26), with low heterogeneity among the studies (I(2)=25%, P=0.160) and no evidence for publication bias. Meta-analysis of multivariate hazard ratios and sensitivity analyses did not materially change the results. The data on disease-free survival was heterogeneous (I(2)=61.9%, P<0.001), with a summary hazard ratio of 1.57 (95% confidence interval 1.31-1.89). The exact source of heterogeneity remains unclear. We thus concluded that PTEN negativity was significantly associated with unfavorable prognosis in terms of overall survival in breast cancer.
authors.affiliation: Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Zu-Yao
authors.initials: ZY
authors.lastname: Yang
authors.affiliation: Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Yu
authors.affiliation: Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Jin-Qiu
authors.initials: JQ
authors.lastname: Yuan
authors.affiliation: Cancer Institute, Shenzhen People's Hospital (2nd Clinical Medical College of Jinan University), Shenzhen, Guangdong Province, China.
authors.forename: Wei-Xi
authors.initials: WX
authors.lastname: Shen
authors.affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
authors.forename: Da-Yong
authors.initials: DY
authors.lastname: Zheng
authors.affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
authors.forename: Jin-Zhang
authors.initials: JZ
authors.lastname: Chen
authors.affiliation: Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong; Shenzhen Key Laboratory for Health Risk Analysis, Shenzhen Research Institute of The Chinese University of Hong Kong, Shenzhen, Guangdong Province, China. Electronic address: maochen@cuhk.edu.hk.
authors.forename: Chen
authors.initials: C
authors.lastname: Mao
authors.affiliation: Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong; Shenzhen Key Laboratory for Health Risk Analysis, Shenzhen Research Institute of The Chinese University of Hong Kong, Shenzhen, Guangdong Province, China; The Hong Kong Branch of The Chinese Cochrane Centre, The Chinese University of Hong Kong, Hong Kong. Electronic address: jltang@cuhk.edu.hk.
authors.forename: Jin-Ling
authors.initials: JL
authors.lastname: Tang
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D018572:Disease-Free Survival; D006801:Humans; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D011379:Prognosis; D000070876:Tensins / Q000378:metabolism*
chemical_list: D000070876:Tensins; D010749:Phosphoprotein Phosphatases
keywords: breast cancer; disease-free survival; meta-analysis; overall survival; phosphatase and tensin homolog; prognosis; systematic review