title: Subunit vaccines for the prevention of mucosal infection with Chlamydia trachomatis.
abstract: Chlamydia trachomatis is the most common preventable cause of tubal infertility in women. In high-income countries, despite public health control efforts, C. trachomatis case rates continue to rise. Most medium and low-income countries lack any Chlamydia control program; therefore, a vaccine is essential for the control of Chlamydia infections. A rationally designed Chlamydia vaccine requires understanding of the immunological correlates of protective immunity, pathological responses to this mucosal pathogen, identification of optimal vaccine antigens and selection of suitable adjuvant delivery systems that engender protective immunity. Fortunately, Chlamydia vaccinology is facilitated by genomic knowledge and by murine models that reproduce many of the features of human C. trachomatis infection. This article reviews recent progress in these areas with a focus on subunit vaccine development.
authors.affiliation: a Vaccine Research Laboratory , University of British Columbia Centre for Disease Control , Vancouver , British Columbia , Canada.
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.affiliation: a Vaccine Research Laboratory , University of British Columbia Centre for Disease Control , Vancouver , British Columbia , Canada.
authors.forename: Karuna P
authors.initials: KP
authors.lastname: Karunakaran
authors.affiliation: a Vaccine Research Laboratory , University of British Columbia Centre for Disease Control , Vancouver , British Columbia , Canada.
authors.forename: Xiaozhou
authors.initials: X
authors.lastname: Jiang
authors.affiliation: a Vaccine Research Laboratory , University of British Columbia Centre for Disease Control , Vancouver , British Columbia , Canada.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Brunham
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D002690:Chlamydia Infections / Q000517:prevention & control*; D002692:Chlamydia trachomatis / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; D022223:Vaccines, Subunit
keywords: Chlamydia; adjuvant; antigen; immunoproteomics; tissue-resident memory T cells; vaccine