title: Optimizing Salmonella enterica serovar Typhimurium for bacteria-mediated tumor therapy.
abstract: Bacteria-mediated tumor therapy using Salmonella enterica serovar Typhimurium is a therapeutic option with great potential. Numerous studies explored the potential of Salmonella Typhimurium for therapeutic applications, however reconciling safety with vectorial efficacy remains a major issue. Recently we have described a conditionally attenuated Salmonella vector that is based on genetic lipopolysaccharide modification. This vector combines strong attenuation with appropriate anti-tumor properties by targeting various cancerous tissues in vivo. Therefore, it was promoted as an anti-tumor agent. In this addendum, we summarize these findings and demonstrate additional optimization steps that may further improve the therapeutic efficacy of our vector strain.
authors.affiliation: a Department of Molecular Immunology , Helmholtz Centre for Infection Research , Braunschweig , Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Felgner
authors.affiliation: a Department of Molecular Immunology , Helmholtz Centre for Infection Research , Braunschweig , Germany.
authors.forename: Dino
authors.initials: D
authors.lastname: Kocijancic
authors.affiliation: a Department of Molecular Immunology , Helmholtz Centre for Infection Research , Braunschweig , Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Frahm
authors.affiliation: b Department of Infectious Diseases and Pathology , University of Florida , Gainesville , USA.
authors.forename: Roy
authors.initials: R
authors.lastname: Curtiss
authors.affiliation: c Junior Research Group Infection Biology of Salmonella, Helmholtz Centre for Infection Research , Braunschweig , Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Erhardt
authors.affiliation: a Department of Molecular Immunology , Helmholtz Centre for Infection Research , Braunschweig , Germany.|d Institute of Immunology, Medical School Hannover , Hannover , Germany.
authors.forename: Siegfried
authors.initials: S
authors.lastname: Weiss
mesh_terms: D000818:Animals; D001691:Biological Therapy; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D012486:Salmonella typhimurium / Q000235:genetics / Q000276:immunology*
keywords: LPS; Lipid A; Salmonella Typhimurium; UK-1; bacteria-mediated tumor therapy