title: Abietane diterpenoids from Caryopteris incana (Thunb.) Miq.
abstract: Twelve new diterpenes, caryopincaolide A-L (1-4, 11-12, 16-19, 27-28), together with twenty-eight known diterpenes, have been isolated from the whole plant of Caryopteris incana (Thunb.) Miq. Their structures were elucidated on the basis of 1D and 2D NMR, IR, X-ray crystal diffraction and mass spectroscopic data, as well as ECD calculations. All compounds were tested for in vitro dipeptidyl peptidase IV (DPP-IV) inhibitory activity, with compounds 3, 4, 28, 29, and 40 exhibiting DPP-IV inhibitory effects with IC50 values ranging from 54.2 to 228.9 μM. Compounds 1, 3 and 4 also showed potent activity toward the inhibition of the growth of human cancer cells and 1 can induce apoptosis in Hey and A-549 cells.
authors.affiliation: Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. chouguixinzyb@126.com.
authors.forename: Sen-Miao
authors.initials: SM
authors.lastname: Zhao
authors.forename: Gui-Xin
authors.initials: GX
authors.lastname: Chou
authors.forename: Qing-Shan
authors.initials: QS
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Zhou
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification*; D018360:Crystallography, X-Ray; D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared
chemical_list: D045784:Abietanes