title: An analysis of the differences between early and late preeclampsia with severe hypertension.
abstract: Preeclampsia is clinically divided into early onset and late onset preeclampsia based on the gestational age at delivery. Although the diagnostic criteria are the same in each subgroup of preeclampsia, it has been suggested that the maternal and perinatal mortalities of early onset and late onset preeclampsia are different. However, studies that compare clinical parameters or laboratory biomarkers between early onset and late onset preeclampsia are limited. Data on 177 women with early or late preeclampsia with severe hypertension were collected from a University Teaching Hospital from January 2010 to January 2011 and analysed. Data included all the clinical parameters and laboratory biomarkers of liver and renal function. 63 women and 114 women were diagnosed with early and late preeclampsia with severe hypertension, respectively. There was no difference in the maternal age and the incidence of clinical symptoms including edema, vision disturbance, severe headache and stillbirth between two groups. There was a decrease in alkaline phosphatase levels in early preeclampsia with severe hypertension but other markers of liver function were not altered. However, renal function including blood urea nitrogen, creatinine and uric acid were significantly higher in early preeclampsia with severe hypertension. Umbilical artery systolic velocity/diastolic velocity ratio was significantly higher in early preeclampsia with severe hypertension. Our data demonstrates that the laboratory biomarkers of renal function differ between early and late preeclampsia with severe hypertension. The severity of renal dysfunction correlated with the time of delivery in preeclampsia with severe hypertension.
authors.affiliation: Department of Obstetrics & Gynaecology, First Affiliated Hospital of Xi'an Jiaotong University, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Li
authors.affiliation: Department of Obstetrics & Gynaecology, Third Affiliated Hospital of Sun-Yat Sen University, Guangzhou, China.
authors.forename: P L
authors.initials: PL
authors.lastname: Guo
authors.affiliation: Department of Obstetrics & Gynaecology, First Affiliated Hospital of Xi'an Jiaotong University, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Obstetrics & Gynaecology, First Affiliated Hospital of Xi'an Jiaotong University, China.
authors.forename: W L
authors.initials: WL
authors.lastname: Gou
authors.affiliation: Department of Obstetrics & Gynaecology, The University of Auckland, New Zealand.
authors.forename: M
authors.initials: M
authors.lastname: Tong
authors.affiliation: The Hospital of Obstetrics & Gynaecology, Fudan University, China; Department of Obstetrics & Gynaecology, The University of Auckland, New Zealand. Electronic address: q.chen@auckland.ac.nz.
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002681:China / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008099:Liver / Q000503:physiopathology; D008111:Liver Function Tests; D010920:Placenta / Q000503:physiopathology; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Early preeclampsia with severe hypertension; Late preeclampsia with severe hypertension; Renal functions