title: Hepatitis C Virus Exploitation of Processing Bodies.
abstract: During infection, positive-strand RNA viruses subvert cellular machinery involved in RNA metabolism to translate viral proteins and replicate viral genomes to avoid or disable the host defense mechanisms. Cytoplasmic RNA granules modulate the stabilities of cellular and viral RNAs. Understanding how hepatitis C virus and other flaviviruses interact with the host machinery required for protein synthesis, localization, and degradation of mRNAs is important for elucidating how these processes occur in both virus-infected and uninfected cells.
authors.affiliation: Department of Biological Sciences, The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Biegel
authors.affiliation: Department of Biological Sciences, The RNA Institute, University at Albany, State University of New York, Albany, New York, USA ctpager@albany.edu.
authors.forename: Cara T
authors.initials: CT
authors.lastname: Pager
mesh_terms: D003594:Cytoplasmic Granules / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D016679:Genome, Viral; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000276:immunology; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D012367:RNA, Viral