title: One new linear C14 polyacetylene glucoside with antiadipogenic activities on 3T3-L1 cells from the capitula of Coreopsis tinctoria.
abstract: Based on characteristic UV spectrum of the ene-diyne chromophore, one new polyacetylene glucoside and three known polyacetylene glucosides have been isolated from the EtOH extract of Coreopsis tinctoria. Their chemical structures were determined by detailed spectroscopic analysis and by comparison with literature data. Compounds 1-2 were tested for their antiadipogenic effects on 3T3-L1 adipocytes, and both of them reduced lipid accumulation dose-dependently in 3T3-L1 adipocytes.
authors.affiliation: a West China-Washington Mitochondria and Metabolism Center, West China Hospital/West China Medical School , Sichuan University , Chengdu 610041 , China.
authors.forename: Dan
authors.initials: D
authors.lastname: Du
authors.affiliation: b Department of Integrated Traditional Chinese and Western Medicine, West China Hospital , Sichuan University , Chengdu 610041 , China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jin
authors.affiliation: c Laboratory of Ethnopharmacology, West China Hospital/West China Medical School , Sichuan University , Chengdu 610041 , China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Xing
authors.affiliation: a West China-Washington Mitochondria and Metabolism Center, West China Hospital/West China Medical School , Sichuan University , Chengdu 610041 , China.
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Hu
authors.affiliation: d Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital , Sichuan University , Chengdu 610041 , China.
authors.forename: Dan
authors.initials: D
authors.lastname: Long
authors.affiliation: d Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital , Sichuan University , Chengdu 610041 , China.
authors.forename: Sheng-Fu
authors.initials: SF
authors.lastname: Li
authors.affiliation: a West China-Washington Mitochondria and Metabolism Center, West China Hospital/West China Medical School , Sichuan University , Chengdu 610041 , China.
authors.forename: Meng
authors.initials: M
authors.lastname: Gong
mesh_terms: D041721:3T3-L1 Cells / Q000187:drug effects; D017667:Adipocytes / Q000187:drug effects*; D000818:Animals; D031945:Coreopsis / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D005960:Glucosides; C000613171:coreoside A; C000613170:coreoside E; D053279:Polyynes
keywords: 3T3-L1; Asteraceae; Coreopsis tinctoria; antiadipogenic effect; polyacetylene glucosides