title: Oxidant/antioxidant balance in the aqueous humor of patients with glaucoma.
abstract: OBJECTIVE
  To evaluate total antioxidant status (TAS), total oxidant status (TOS), and the oxidative stress index (OSI) of the aqueous humor (AH) in patients with glaucoma.
  
  
  METHODS
  The prospective study was composed of a study group (n=31) and a control group (n=31). Fifteen patients in the study group were diagnosed with primary open angle glaucoma (POAG), and 16 patients were diagnosed with pseudoexfoliation glaucoma (PEG). The control group was composed of non-glaucomatous patients with cataracts. AH samples were collected and analyzed for TAS, TOS, and OSI levels.
  
  
  RESULTS
  Mean AH TAS level was significantly higher in patients with glaucoma than that in the control group (P<0.01). Mean TOS and OSI levels tended to increase in patients with glaucoma. No significant differences in TAS, TOS, or OSI levels were observed between patients with POAG and PEG.
  
  
  CONCLUSIONS
  High levels of TAS were observed in patients with glaucoma, which was likely a response to the increased oxidative stress observed in these patients.
authors.affiliation: Department of Ophthalmology, Amasya University, Sabuncuoglu Serefeddin Research and Training Hospital, Amasya 05200, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Ergan
authors.affiliation: Department of Ophthalmology, Hacettepe University, Ankara 06230, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Ozturk
authors.affiliation: Department of Ophthalmology, Samsun Research and Training Hospital, Samsun 55100, Turkey.
authors.forename: Emrullah
authors.initials: E
authors.lastname: Beyazyildiz
authors.affiliation: Department of Opthalmology, Ulucanlar Eye Research Hospital, Ankara 06240, Turkey.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Elgin
authors.affiliation: Department of Opthalmology, Ulucanlar Eye Research Hospital, Ankara 06240, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Sen
authors.affiliation: Department of Opthalmology, Ulucanlar Eye Research Hospital, Ankara 06240, Turkey.
authors.forename: Ali Bulent
authors.initials: AB
authors.lastname: Cankaya
authors.affiliation: Department of Biochemistry, Turgut Ozal University, Ankara 06010, Turkey.
authors.forename: Tugrul
authors.initials: T
authors.lastname: Celik
keywords: oxidative stress; primary open angle glaucoma; pseudoexfoliation glaucoma; total antioxidant status; total oxidant status