title: CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10.
abstract: The superfamily of G-protein-coupled receptors (GPCR) conveys signals in response to various endogenous and exogenous stimuli. Consequently, GPCRs are the most important drug targets. CCR10, the receptor for the chemokines CCL27/CTACK and CCL28/MEC, belongs to the chemokine receptor subfamily of GPCRs and is thought to function in immune responses and tumour progression. However, there is only limited information on the intracellular regulation of CCR10. We find that S100A10, a member of the S100 family of Ca(2+) binding proteins, binds directly to the C-terminal cytoplasmic tail of CCR10 and that this interaction regulates the CCR10 cell surface presentation. This identifies S100A10 as a novel interaction partner and regulator of CCR10 that might serve as a target for therapeutic intervention.
authors.affiliation: Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, and Interdisciplinary Clinical Research Centre, University of Muenster, Von-Esmarch-Str. 56, D-48149 Muenster, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Hessner
authors.affiliation: Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, and Interdisciplinary Clinical Research Centre, University of Muenster, Von-Esmarch-Str. 56, D-48149 Muenster, Germany.
authors.forename: C P
authors.initials: CP
authors.lastname: Dlugos
authors.affiliation: Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, and Interdisciplinary Clinical Research Centre, University of Muenster, Von-Esmarch-Str. 56, D-48149 Muenster, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Chehab
authors.affiliation: Department of Internal Medicine D, Molecular Nephrology, University Hospital of Muenster, Albert-Schweitzer Campus 1, A14, and Interdisciplinary Clinical Research Centre, D-48149 Muenster, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Schaefer
authors.affiliation: Department of Dermatology, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Homey
authors.affiliation: Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, and Interdisciplinary Clinical Research Centre, University of Muenster, Von-Esmarch-Str. 56, D-48149 Muenster, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Gerke
authors.affiliation: Department of Internal Medicine D, Molecular Nephrology, University Hospital of Muenster, Albert-Schweitzer Campus 1, A14, and Interdisciplinary Clinical Research Centre, D-48149 Muenster, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Weide
authors.affiliation: Department of Internal Medicine D, Molecular Nephrology, University Hospital of Muenster, Albert-Schweitzer Campus 1, A14, and Interdisciplinary Clinical Research Centre, D-48149 Muenster, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Pavenstädt
authors.affiliation: Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, and Interdisciplinary Clinical Research Centre, University of Muenster, Von-Esmarch-Str. 56, D-48149 Muenster, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Rescher
mesh_terms: D017306:Annexin A2 / Q000378:metabolism*; D045744:Cell Line, Tumor; D005786:Gene Expression Regulation; D006801:Humans; D008544:Melanocytes / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D011485:Protein Binding; D025941:Protein Interaction Mapping; D054447:Receptors, CCR10 / Q000378:metabolism*; D009418:S100 Proteins / Q000378:metabolism*; D000099248:S100 Calcium Binding Protein A10
chemical_list: D017306:Annexin A2; D008565:Membrane Proteins; D054447:Receptors, CCR10; D009418:S100 Proteins; D000099248:S100 Calcium Binding Protein A10; C515706:CCR10 protein, human