title: Optimization of the synthesis process of an iron oxide nanocatalyst supported on activated carbon for the inactivation of Ascaris eggs in water using the heterogeneous Fenton-like reaction.
abstract: An experimental design methodology was used to optimize the synthesis of an iron-supported nanocatalyst as well as the inactivation process of Ascaris eggs (Ae) using this material. A factor screening design was used for identifying the significant experimental factors for nanocatalyst support (supported %Fe, (w/w), temperature and time of calcination) and for the inactivation process called the heterogeneous Fenton-like reaction (H2O2 dose, mass ratio Fe/H2O2, pH and reaction time). The optimization of the significant factors was carried out using a face-centered central composite design. The optimal operating conditions for both processes were estimated with a statistical model and implemented experimentally with five replicates. The predicted value of the Ae inactivation rate was close to the laboratory results. At the optimal operating conditions of the nanocatalyst production and Ae inactivation process, the Ascaris ova showed genomic damage to the point that no cell reparation was possible showing that this advanced oxidation process was highly efficient for inactivating this pathogen.
authors.affiliation: Instituto de Ingeniería, Universidad Nacional Autónoma de México, México D.F., México E-mail: rramirezz@iingen.unam.mx.
authors.forename: Ariadna A
authors.initials: AA
authors.lastname: Morales-Pérez
authors.affiliation: Departamento de Ecología de Agentes Patógenos, Hospital General Dr. Manuel Gea González, SSA, México D.F. 14000, México.
authors.forename: Pablo
authors.initials: P
authors.lastname: Maravilla
authors.affiliation: Instituto de Ingeniería, Universidad Nacional Autónoma de México, México D.F., México E-mail: rramirezz@iingen.unam.mx.
authors.forename: Myriam
authors.initials: M
authors.lastname: Solís-López
authors.affiliation: Departamento de Materiales y Manufactura, DIMEI, Universidad Nacional Autónoma de México, México D.F., México.
authors.forename: Rafael
authors.initials: R
authors.lastname: Schouwenaars
authors.affiliation: Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, México, D. F. 04510, México.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Durán-Moreno
authors.affiliation: Instituto de Ingeniería, Universidad Nacional Autónoma de México, México D.F., México E-mail: rramirezz@iingen.unam.mx.
authors.forename: Rosa-María
authors.initials: RM
authors.lastname: Ramírez-Zamora
mesh_terms: D000818:Animals; D001200:Ascaris / Q000187:drug effects*; D002244:Carbon / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D006861:Hydrogen Peroxide; D049329:Nanostructures / Q000737:chemistry*; D010063:Ovum / Q000737:chemistry*; D010084:Oxidation-Reduction; D014867:Water / Q000469:parasitology*; D014874:Water Pollutants, Chemical / Q000032:analysis; D018508:Water Purification / Q000379:methods
chemical_list: D005290:Ferric Compounds; D014874:Water Pollutants, Chemical; D014867:Water; C000499:ferric oxide; D002244:Carbon; D006861:Hydrogen Peroxide