title: Association of ICAM-1 (K469E) and MCP-1 -2518 A>G gene polymorphism with brain abscess.
abstract: Brain abscess develops in response to a parenchymal infection. Intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) play vital role in central nervous system (CNS) diseases. We studied ICAM-1 (K469E) and MCP-1 (-2518 A>G) polymorphisms among brain abscess patients. The genotypic distributions of ICAM-1 (K469E) and MCP-1 (-2518 A>G) were significantly different between patients and controls. Further, patient with predisposing factors, and also with culture result, we found significant association. The study revealed that the polymorphisms of these molecules lead to increased production, which appears to be a risk for the development of brain abscess.
authors.affiliation: Departments of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Mishra
authors.affiliation: Departments of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. Electronic address: kashinprasad@gmail.com.
authors.forename: Kashi Nath
authors.initials: KN
authors.lastname: Prasad
authors.affiliation: Departments of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
authors.forename: Kamini
authors.initials: K
authors.lastname: Singh
authors.affiliation: Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, India.
authors.forename: Rabi Narayan
authors.initials: RN
authors.lastname: Sahu
authors.affiliation: Department of Neurosurgery, King George Medical University, Lucknow, India.
authors.forename: Bal Krishna
authors.initials: BK
authors.lastname: Ojha
mesh_terms: D000293:Adolescent; D000328:Adult; D001922:Brain Abscess / Q000235:genetics*; D018932:Chemokine CCL2 / Q000235:genetics*; D002648:Child; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*; D055815:Young Adult
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D018799:Intercellular Adhesion Molecule-1
keywords: Brain abscess; ICAM-1; MCP-1; Polymorphisms; Serum level