title: Piracetam prevents memory deficit induced by postnatal propofol exposure in mice.
abstract: Postnatal propofol exposure impairs hippocampal synaptic development and memory. However, the effective agent to alleviate the impairments was not verified. In this study, piracetam, a positive allosteric modulator of AMPA receptor was administered following a seven-day propofol regime. Two months after propofol administration, hippocampal long-term potentiation (LTP) and long-term memory decreased, while intraperitoneal injection of piracetam at doses of 100mg/kg and 50mg/kg following last propofol exposure reversed the impairments of memory and LTP. Mechanically, piracetam reversed propofol exposure-induced decrease of BDNF and phosphorylation of mTor. Similar as piracetam, BDNF supplementary also ameliorated propofol-induced abnormalities of synaptic plasticity-related protein expressions, hippocampal LTP and long-term memory. These results suggest that piracetam prevents detrimental effects of propofol, likely via activating BDNF synthesis.
authors.affiliation: Department of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China.
authors.forename: Yuan-Lin
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, the First People's Hospital of Yancheng, Yancheng 224006, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China. Electronic address: xin_chen12@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D000076122:Disks Large Homolog 4 Protein; D004789:Enzyme Activation / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D051528:Guanylate Kinases / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology; D017774:Long-Term Potentiation / Q000187:drug effects; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008569:Memory Disorders / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D051379:Mice; D010889:Piracetam / Q000494:pharmacology*; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000076122:Disks Large Homolog 4 Protein; C501447:Dlg4 protein, mouse; D008565:Membrane Proteins; D017868:Cyclic AMP-Dependent Protein Kinases; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D051528:Guanylate Kinases; D015742:Propofol; D010889:Piracetam
keywords: BDNF; Long-term Potentiation; Memory; Piracetam; Propofol