title: TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance.
abstract: Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. Transforming growth factor-β1 (TGF-β1) has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding of LC ontogeny and diverse replenishment patterns, the underlying molecular mechanisms remain elusive. This review focuses on the recent discoveries in TGF-β1-mediated LC development and maintenance, with special attention to the involved transcription factors and related regulators.
authors.affiliation: Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Second Military Medical University Changhai Hospital, Shanghai, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Second Military Medical University Changhai Hospital, Shanghai, China.
authors.forename: J
authors.initials: J
authors.lastname: Gu
authors.affiliation: Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI, USA.|Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: F-S
authors.initials: FS
authors.lastname: Yu
authors.affiliation: Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.|Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.|Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.|Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.|Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: Q-S
authors.initials: QS
authors.lastname: Mi
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006801:Humans; D007801:Langerhans Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
chemical_list: D014157:Transcription Factors; D053773:Transforming Growth Factor beta1
keywords: TGF-β1; development; langerhans cells; transcription factors