title: Potential antimalarial activity of Methyl Jasmonate and its effect on lipid profiles in Plasmodium Berghei infected mice.
abstract: BACKGROUND
  The antimalarial activity and lipid profiles of Methyl Jasmonate (MJ) were investigated against established malaria infection in vivo using BALB/c mice.
  
  
  METHODS
  Arteether (AE) and chloroquine (CQ) were used as reference drugs while ethanol was used as the vehicle for drug delivery for MJ.
  
  
  RESULTS
  Mice treated with 10 and 25 mg/kg MJ showed a remarkable reduction in percentage parasitemia by 68.3% and 78.2% on day 10(post treatment) respectively while 45.4% and 87.2% reduction in percentage parasitemia were observed in the group treated with 50 mg/kg on day 3 and 10 (post treatment) respectively. The highest mean survival time was observed in CQ followed by AE and MJ in dose-dependent manner. A progressive decrease in packed cell volume (PCV) was observed in infected untreated mice which led to the death of all the mice by day 9 (post treatment). Infected mice treated with MJ showed reduced level of HDL and LDL compared with infected untreated group. As the dose of MJ increased in infected mice cholesterol levels increased while there was reduction in triglyceride.
  
  
  CONCLUSIONS
  Overall there was marked decrease in parasitemia in Plasmodium berghei infected mice treated with graded doses of MJ but appears to have reduced antimalarial activity compared with CQ and AE.
authors.affiliation: University of Ibadan, Department of Pharmacology and Therapeutics, College of Medicine.
authors.forename: Oladapo E
authors.initials: OE
authors.lastname: Oyinloye
authors.affiliation: University of Ibadan, Department of Biochemistry.
authors.forename: Ayokulehin M
authors.initials: AM
authors.lastname: Kosoko
authors.affiliation: University of Ibadan, Department of Veterinary Pathology.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Emikpe
authors.affiliation: University of Ibadan, Department of Pharmacology and Therapeutics, College of Medicine.
authors.forename: Catherine O
authors.initials: CO
authors.lastname: Falade
authors.affiliation: University of Ibadan, Institute for Advanced Medical Research and Training (IAMRAT), College of Medicine.
authors.forename: Olusegun G
authors.initials: OG
authors.lastname: Ademowo
mesh_terms: D000085:Acetates / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D037621:Artemisinins / Q000494:pharmacology* / Q000627:therapeutic use; D002738:Chloroquine / Q000494:pharmacology* / Q000627:therapeutic use; D003517:Cyclopentanes / Q000494:pharmacology* / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D054883:Oxylipins / Q000494:pharmacology* / Q000627:therapeutic use; D018512:Parasitemia / Q000188:drug therapy*; D010962:Plasmodium berghei / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000085:Acetates; D000962:Antimalarials; D037621:Artemisinins; D003517:Cyclopentanes; D054883:Oxylipins; D002738:Chloroquine; C072239:methyl jasmonate; C055141:artemotil
keywords: Antimalarial activity; Lipid profile; Methyl jasmonate; Mice; Plasmodium berghei