title: Doxycycline as a matrix metalloproteinase inhibitor to prevent bond degradation: the effect of acid and neutral solutions on dentin bond strength.
abstract: The aim of this in vitro study was to evaluate the pH effect of doxycycline solutions on the immediate dentin bond strength of a total-etch adhesive system. Twenty human molars were divided into 4 groups (n = 5) after acid etching according to surface treatment: 10% acidic doxycycline, 10% neutral doxycycline, 2% chlorhexidine, and control. Composite resin blocks were made and subjected to microtensile testing. Mean bond strength values were submitted to a 1-way analysis of variance and a Tukey test (α = 0.05). No statistically significant differences between the experimental groups were found (P = 0.093). The chlorhexidine group showed the highest number of pretesting failures. The application of either acidic or neutral doxycycline solution prior to the dentin adhesive did not influence the bond strength of the total-etch adhesive system evaluated.
authors.forename: Hellen de Lacerda
authors.initials: Hde L
authors.lastname: Oliveira
authors.forename: Tamara Kerber
authors.initials: TK
authors.lastname: Tedesco
authors.forename: Leonardo Eloy
authors.initials: LE
authors.lastname: Rodrigues-Filho
authors.forename: Fabio Zovico Maxnuck
authors.initials: FZ
authors.lastname: Soares
authors.forename: Rachel de Oliveira
authors.initials: Rde O
authors.lastname: Rocha
mesh_terms: D003188:Composite Resins / Q000627:therapeutic use; D001840:Dental Bonding / Q000379:methods; D003738:Dental Cements / Q000627:therapeutic use*; D003799:Dental Stress Analysis; D017220:Dentin-Bonding Agents / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use*; D006801:Humans; D066298:In Vitro Techniques; D061965:Matrix Metalloproteinase Inhibitors / Q000627:therapeutic use*
chemical_list: D003188:Composite Resins; D003738:Dental Cements; D017220:Dentin-Bonding Agents; D061965:Matrix Metalloproteinase Inhibitors; D004318:Doxycycline
keywords: adhesive system; chlorhexidine; matrix metalloproteinases; tetracyclines