title: Clinical features and treatment of hypertriglyceridemia-induced acute pancreatitis during pregnancy: A retrospective study.
abstract: OBJECTIVE
  To analyze the features and treatment of hypertriglyceridemia-induced acute pancreatitis (HTGP) during pregnancy.
  
  
  METHODS
  A retrospective study of 21 pregnant women diagnosed with acute pancreatitis (AP) was performed. Patients were divided into acute biliary pancreatitis (ABP), HTGP, and idiopathic groups according to etiology.
  
  
  RESULTS
  95% of the patients were in the third trimester of gestation. The percentage of patients with HTGP was higher than that of ABP (48% vs.14%). The percentage of severe acute pancreatitis (SAP) in the HTGP group was higher than that in the ABP group (40.0% vs.0%). The Ranson scores for moderately severe acute pancreatitis (MSAP) and SAP in the HTGP group were significantly different (2.50 ± 0.58 vs.3.60 ± 0.89, P < 0.05, respectively). The mean serum triglyceride (TG) levels in the MSAP and SAP HTGP groups were not significantly different (18.81 ± 11.13 vs. 30.53 ± 24.20 mmol/L, P > 0.05, respectively). In the HTGP group, there were five patients given plasma exchange therapy and five not. Plasmapheresis decreased the incidence of systemic inflammatory response syndrome (SIRS) from 100% to 28.6% and the TG level from 20.36 ± 7.41 mmol/L to 5.23 ± 3.62 mmol/L (P < 0.05). The length of hospitalization of the plasmapheresis group was shorter than that of the nonplasmapheresis group (17.3 ± 6.7 days vs. 37.0 ± 20.8 days).
  
  
  CONCLUSIONS
  Plasma exchange may be safe and effectively administered for HTGP patients during pregnancy with SIRS or multiple organ dysfunction syndrome (MODS). J. Clin. Apheresis 31:571-578, 2016. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
authors.forename: Chunlan
authors.initials: C
authors.lastname: Huang
authors.affiliation: Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.|Department of Gastroenterology, Suzhou Science and Technology City Hospital, Suzhou City, Jiangsu Province, 215000, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Fan
authors.affiliation: Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
authors.forename: Xingpeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications*; D009102:Multiple Organ Failure / Q000517:prevention & control; D010195:Pancreatitis / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D061214:Patient Safety; D010956:Plasmapheresis; D011247:Pregnancy; D012189:Retrospective Studies; D018746:Systemic Inflammatory Response Syndrome / Q000517:prevention & control; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides
keywords: acute pancreatitis; hypertriglyceridemia-induced acute pancreatitis; plasma exchange; pregnancy