title: Patterns of subretinal fluid resolution in Group D eyes treated with chemoreduction: Experience from the Children's Hospital Los Angeles/University of Southern California.
abstract: The purpose of this study was to evaluate patterns of subretinal fluid (SRF) resolution in Group D retinoblastoma eyes. Fifty-three Group D eyes were evaluated for the presence of SRF at diagnosis. They were subsequently treated with systemic chemoreduction (CRD) and the duration of SRF was evaluated. Logistic regression analysis was used to assess the association between duration of SRF and enucleation. Among the 53 Group D eyes, 42 eyes exhibited SRF at diagnosis (79%). After the first cycle of CRD, 27/42 eyes showed SRF (64%); 8/42 eyes demonstrated SRF after three cycles of CRD (19%), and only 3/42 eyes had SRF after six cycles (7%). Ten eyes were enucleated (10/53 or 19%). Only 1 of 10 eyes demonstrated persistent SRF at the time of enucleation. This retrospective analysis of patterns of subretinal fluid in retinoblastoma eyes demonstrates that 80% of Group D eyes present with SRF. Of these eyes, approximately 60% have persistent fluid after one cycle of CRD and less than 10% have persistent fluid after six cycles. However, presence or persistence of SRF during chemoreduction was not found to be a risk factor for enucleation in Group D retinoblastoma eyes.
authors.affiliation: a The Vision Center at Children's Hospital Los Angeles , Los Angeles , California , USA.|b The USC Eye Institute , University of Southern California Keck School of Medicine , Los Angeles , California , USA.
authors.forename: Jesse L
authors.initials: JL
authors.lastname: Berry
authors.affiliation: b The USC Eye Institute , University of Southern California Keck School of Medicine , Los Angeles , California , USA.
authors.forename: Grace
authors.initials: G
authors.lastname: Shih
authors.affiliation: b The USC Eye Institute , University of Southern California Keck School of Medicine , Los Angeles , California , USA.
authors.forename: Stavros N
authors.initials: SN
authors.lastname: Moysidis
authors.affiliation: c The Children's Center for Cancer and Blood Diseases , Children's Hospital Los Angeles , Los Angeles , California , USA.
authors.forename: Rima
authors.initials: R
authors.lastname: Jubran
authors.affiliation: d Radiation Oncology Program , Children's Hospital Los Angeles , Los Angeles , California , USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Wong
authors.affiliation: a The Vision Center at Children's Hospital Los Angeles , Los Angeles , California , USA.|b The USC Eye Institute , University of Southern California Keck School of Medicine , Los Angeles , California , USA.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Lee
authors.affiliation: a The Vision Center at Children's Hospital Los Angeles , Los Angeles , California , USA.|b The USC Eye Institute , University of Southern California Keck School of Medicine , Los Angeles , California , USA.
authors.forename: A Linn
authors.initials: AL
authors.lastname: Murphree
authors.affiliation: a The Vision Center at Children's Hospital Los Angeles , Los Angeles , California , USA.|b The USC Eye Institute , University of Southern California Keck School of Medicine , Los Angeles , California , USA.
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Kim
mesh_terms: D000046:Academic Medical Centers; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use; D002675:Child, Preschool; D005047:Etoposide / Q000627:therapeutic use; D015353:Eye Enucleation; D005260:Female; D005500:Follow-Up Studies; D006776:Hospitals, Pediatric; D006801:Humans; D015141:Los Angeles; D008297:Male; D019572:Retinal Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D012175:Retinoblastoma / Q000188:drug therapy* / Q000378:metabolism; D012189:Retrospective Studies; D058471:Subretinal Fluid / Q000378:metabolism*; D013997:Time Factors; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D005047:Etoposide; D016190:Carboplatin
keywords: Chemoreduction; chemotherapy; retinal detachment; retinoblastoma; subretinal fluid