title: Radiotherapy supports tumor-specific immunity by acute inflammation.
abstract: Local immune stimulation is an integral part of radiotherapy. Production of anaphylatoxins is a crucial initial event in radiotherapy-induced immunity and clinical efficacy. We propose applying radiotherapy in few fractions and include radiation holidays to achieve acute rather than chronic inflammatory responses, which promote protective immunity and therapeutic efficacy.
authors.affiliation: Institute of Experimental Immunology; University of Zurich; Winterthurerstrasse ; Zurich, Switzerland.
authors.forename: Laura
authors.initials: L
authors.lastname: Surace
authors.affiliation: Institute of Experimental Immunology; University of Zurich; Winterthurerstrasse ; Zurich, Switzerland.
authors.forename: Nicole Angelika
authors.initials: NA
authors.lastname: Scheifinger
authors.affiliation: Institute of Experimental Immunology; University of Zurich; Winterthurerstrasse ; Zurich, Switzerland.
authors.forename: Anurag
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Institute of Experimental Immunology; University of Zurich; Winterthurerstrasse ; Zurich, Switzerland.
authors.forename: Maries
authors.initials: M
authors.lastname: van den Broek
keywords: cancer; immune response; inflammation; radiotherapy