title: tert-Butyl Hydroperoxide Mediated Cascade Synthesis of 3-Arylsulfonylquinolines.
abstract: 3-Arylsulfonylquinoline derivatives play important roles as pharmaceutical drugs. A new method for the synthesis of 3-arylsulfonylquinoline derivatives has been achieved through tert-butyl hydroperoxide mediated cycloaddition between N-propargyl aromatic amine derivatives and arylsulfonylhydrazides without the addition of any metals. This transformation offers a straightforward route to the formation of a C-S bond and quinoline ring in one step via a sulfonylation-cyclization-aromatization process.
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen 361005, China.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen 361005, China.
authors.forename: Su
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen 361005, China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen 361005, China.
authors.forename: Pengbo
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen 361005, China.
authors.forename: Yile
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen 361005, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Tang
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen 361005, China.|Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D003500:Cyclization; D061565:Cycloaddition Reaction; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013441:Sulfinic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D020122:tert-Butylhydroperoxide / Q000737:chemistry*
chemical_list: D011804:Quinolines; D013441:Sulfinic Acids; D020122:tert-Butylhydroperoxide