title: Role of the Collecting Duct Renin Angiotensin System in Regulation of Blood Pressure and Renal Function.
abstract: Recent evidence suggests that the renal tubular renin angiotensin system regulates urinary Na(+) and water excretion and blood pressure. Three key components of the tubular renin angiotensin system, namely renin, prorenin receptor, and angiotensin-II type 1 receptor, are localized to the collecting duct. This system may modulate collecting duct Na(+) and water reabsorption via angiotensin-II-dependent and angiotensin-II-independent pathways. Further, the system may be of greatest relevance in hypertensive states and particularly those characterized by high circulating angiotensin-II. In this review, we summarize the current knowledge on the synthesis, regulation, and function of collecting duct-derived renin angiotensin system components and examine recent developments with regard to regulation of blood pressure and renal fluid and Na(+) excretion.
authors.affiliation: Division of Nephrology, University of Utah Health Sciences Center, 30 N 1900 E SOM 4R312, Salt Lake City, UT, 84132, USA.
authors.forename: Nirupama
authors.initials: N
authors.lastname: Ramkumar
authors.affiliation: Division of Nephrology, University of Utah Health Sciences Center, 30 N 1900 E SOM 4R312, Salt Lake City, UT, 84132, USA. donald.kohan@hsc.utah.edu.|Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USA. donald.kohan@hsc.utah.edu.
authors.forename: Donald E
authors.initials: DE
authors.lastname: Kohan
mesh_terms: D000818:Animals; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007685:Kidney Tubules, Collecting / Q000503:physiopathology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System; D025262:Vacuolar Proton-Translocating ATPases / Q000378:metabolism; D000093342:Prorenin Receptor
chemical_list: D011956:Receptors, Cell Surface; D012083:Renin; D025262:Vacuolar Proton-Translocating ATPases; C458319:ATP6AP2 protein, human; D000093342:Prorenin Receptor
keywords: Blood pressure; Collecting duct; Hypertension; Prorenin receptor; Renin; Renin angiotensin system