title: Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa.
abstract: The photoreceptor cell death associated with the various genetic forms of retinitis pigmentosa (RP) is currently untreatable and leads to partial or complete vision loss. Carnosic acid (CA) upregulates endogenous antioxidant enzymes and has proven neuroprotective in studies of neurodegenerative models affecting the brain. In this study, we examined the potential effect of CA on photoreceptor death in the Pde6b(rd10) mouse model of RP. Our data shows that CA provided morphological and functional preservation of photoreceptors. CA appears to exert its neuroprotective effects through inhibition of oxidative stress and endoplasmic reticulum stress.
authors.affiliation: Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland OH, USA.
authors.forename: Kai
authors.initials: K
authors.lastname: Kang
authors.affiliation: Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland OH, USA.|Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Tarchick
authors.affiliation: Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland OH, USA.
authors.forename: Xiaoshan
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland OH, USA.|Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA.
authors.forename: Craig
authors.initials: C
authors.lastname: Beight
authors.affiliation: Department of Ophthalmology, Loyola University Chicago, Maywood, IL, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Bu
authors.affiliation: Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland OH, USA.|Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland OH, USA.
authors.forename: Minzhong
authors.initials: M
authors.lastname: Yu
mesh_terms: D045784:Abietanes / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D054707:Cyclic Nucleotide Phosphodiesterases, Type 6 / Q000235:genetics*; D059865:Endoplasmic Reticulum Stress; D051379:Mice; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010786:Photoreceptor Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D012174:Retinitis Pigmentosa / Q000188:drug therapy* / Q000235:genetics
chemical_list: D045784:Abietanes; D000975:Antioxidants; D018696:Neuroprotective Agents; D054707:Cyclic Nucleotide Phosphodiesterases, Type 6; C517438:Pde6b protein, mouse; C018381:salvin