title: Herbicidal and Cytotoxic Constituents from Aralia armata (Wall.) Seem.
abstract: Two new triterpenoids, 3β-hydroxyoleana-11,13(18)-diene-28,30-dioic acid (1) and 3-oxooleana-11,13(18)-diene-28,30-dioic acid (2), one novel triterpenoid glycoside, 3β-O-(6'-O-methyl-β-D-glucuronopyranosyl)oleana-11,13(18)-dien-28-oic acid (3) along with six known compounds (4 - 9) were isolated from the stem bark of Aralia armata (Wall.) Seem. Their structures were elucidated through extensive spectroscopic methods. The herbicidal activities of these compounds against Bidens pilosa L., an invasive weed in P. R. China, were evaluated. Compounds 3, 5, and 6 exhibited more significant herbicidal activities on B. pilosa than the positive-control pendimethalin. Their possible use as herbicidal chemicals or model compounds deserved more attention. The effects of compounds 1 - 9 on Spodoptera litura cultured cell line Sl-1 cell proliferation and its morphology were also evaluated. The results indicated that compounds 1 - 5 affected Sl-1 cell proliferation. Compound 3 showed more obvious proliferation inhibition activities on Sl-1 cell than the positive-control rotenone. With regard to the effect on morphology, compound 2 significantly changed Sl-1 cell, resulting in cell blebbing and vacuole forming. Triterpenoids aremedicinally and agriculturally important, and cytotoxicity of the three new compounds 1 - 3 deserved further studies.
authors.affiliation: Key Laboratory of Natural Pesticide & Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, 510642, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Miao
authors.affiliation: Key Laboratory of Natural Pesticide & Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, 510642, P. R. China.
authors.forename: Yongyan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, P. R. China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Key Laboratory of Natural Pesticide & Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, 510642, P. R. China.
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Natural Pesticide & Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, 510642, P. R. China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Wu
authors.affiliation: Key Laboratory of Natural Pesticide & Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, 510642, P. R. China.
authors.forename: Weiyun
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Natural Pesticide & Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, 510642, P. R. China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D027983:Aralia / Q000737:chemistry*; D002460:Cell Line; D006540:Herbicides / Q000302:isolation & purification*; D018411:Spodoptera
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006540:Herbicides
keywords: Aralia armata; Botanical herbicide; Cytotoxicity; Herbicidal activity; Triterpenoids