title: Testing an anxiety process biomarker: Generalisation from an auditory to a visual stimulus.
abstract: We have previously reported an anxiolytic-sensitive human EEG biomarker, goal conflict specific rhythmicity (GCSR), using an auditory stop signal task (SST). Here we test if a visual SST could allow testing of GCSR in people with hearing impairments. The visual SST produced GCSR within the 4-12Hz band at the expected right frontal site, F8, but to a lesser extent than in previous auditory SSTs, possibly due to response instability. Positive GCSR appeared to be reduced by both buspirone (10mg), and triazolam (0.25mg), as previously; negative GCSR was increased. However, neuroticism, trait anxiety and Behavioural Inhibition System scores failed to show consistent positive correlations with GCSR, contrary to prediction. The visual SST generates anxiolytic-sensitive GCSR; but its limited extent and unexpected personality correlations suggest it needs further development to obtain quantitative equivalence with the auditory SST.
authors.affiliation: Dept. Psychology, University of Otago, Dunedin, New Zealand.
authors.forename: Shabah M
authors.initials: SM
authors.lastname: Shadli
authors.affiliation: Dept. Psychology, University of Otago, Dunedin, New Zealand.
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Smith
authors.affiliation: Dept. Psychological Medicine, University of Otago, Dunedin, New Zealand.
authors.forename: Paul
authors.initials: P
authors.lastname: Glue
authors.affiliation: Dept. Psychology, University of Otago, Dunedin, New Zealand. Electronic address: nmcn@psy.otago.ac.nz.
authors.forename: Neil
authors.initials: N
authors.lastname: McNaughton
mesh_terms: D000293:Adolescent; D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001007:Anxiety / Q000503:physiopathology*; D001307:Auditory Perception / Q000187:drug effects / Q000502:physiology*; D015415:Biomarkers; D058256:Brain Waves / Q000187:drug effects / Q000502:physiology*; D002065:Buspirone / Q000008:administration & dosage / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D003220:Conflict, Psychological; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D014229:Triazolam / Q000008:administration & dosage / Q000494:pharmacology; D014796:Visual Perception / Q000187:drug effects / Q000502:physiology*; D055815:Young Adult
chemical_list: D014151:Anti-Anxiety Agents; D015415:Biomarkers; D014229:Triazolam; D002065:Buspirone
keywords: Anxiolytic; Behavioural inhibition system; Conflict specific rhythmicity; Electroencephalography; Rhythmical slow activity; Stop signal task; Theta