title: ATYPICAL MACULOPATHY IN A PATIENT WITH LIGHT CHAIN DEPOSITION DISEASE MIMICKING ADVANCED GEOGRAPHIC ATROPHY.
abstract: OBJECTIVE
  To report a previously unreported presentation of advanced geographic atrophy of the macula mimicking nonneovascular (dry) age-related macular degeneration in a patient with light chain deposition disease.
  
  
  METHODS
  Ocular examination included dilated fundus examination, fundus autofluorescence, full-field electroretinography, and spectral domain optical coherence tomography.
  
  
  METHODS
  Single-patient case report.
  
  
  RESULTS
  Dilated fundus examination demonstrated diffuse loss of the retinal pigment epithelium in a geographic atrophy pattern in the macula and drusenlike deposits localized to the outer retina and retinal pigment epithelium. There were no signs of choroidal neovascularization or retinal pigment epithelium detachments. Fundus autofluorescence demonstrated wide areas of retinal pigment epithelium loss. Full-field electroretinography was normal. Spectral domain optical coherence tomography displayed atrophy of the outer retinal layers.
  
  
  CONCLUSIONS
  This is the first documented case of drusenlike deposits and maculopathy in a patient with light chain deposition disease that mimics advanced geographic atrophy that is typically observed in nonneovascular age-related macular degeneration. Physicians should be aware of the macular changes that can be associated with light chain deposition disease, and patients with light chain deposition disease should be regularly evaluated for associated macular disease.
authors.affiliation: *New England Eye Center, Tufts University School of Medicine, Boston, Massachusetts; and †Boston University School of Medicine, Boston, Massachusetts.
authors.forename: Courtney
authors.initials: C
authors.lastname: Crawford
authors.forename: Lauren J
authors.initials: LJ
authors.lastname: Oshry
authors.forename: Elias
authors.initials: E
authors.lastname: Reichel
mesh_terms: D005260:Female; D057092:Geographic Atrophy / Q000473:pathology*; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism*; D008268:Macular Degeneration / Q000473:pathology*; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications*; D014786:Vision Disorders / Q000209:etiology
chemical_list: D007145:Immunoglobulin kappa-Chains