title: MRI-Guided Derivation of the Input Function for PET Kinetic Modeling.
abstract: Blood samples obtained by arterial cannulation are the gold standard to measure the input function for PET pharmacokinetic modeling. There is interest in less invasive methods, such as image-derived input functions (IDAIF). MRI can be used to segment and correct partial volume effects of the PET images, improving IDAIF extraction. Preclinical studies have shown that the input function of PET tracers, namely fluorodeoxyglucose and [(18)F]fluoroethyl-l-tyrosine, can be derived from the Gd-DTPA input function. Noninvasive, MRI-guided, PET input function derivation is a promising avenue to reduce or eliminate the need for arterial plasma samples in preclinical and clinical settings.
authors.affiliation: Department of Nuclear Medicine and Radiobiology, Centre d'imagerie moléculaire de Sherbrooke (CIMS), Université de Sherbrooke, Suite 1983, 3001, 12th Avenue North, Sherbrooke, Québec J1H 5N4, Canada.
authors.forename: Marie Anne
authors.initials: MA
authors.lastname: Richard
authors.affiliation: Department of Nuclear Medicine and Radiobiology, Centre d'imagerie moléculaire de Sherbrooke (CIMS), Université de Sherbrooke, Suite 1983, 3001, 12th Avenue North, Sherbrooke, Québec J1H 5N4, Canada.
authors.forename: Jérémie P
authors.initials: JP
authors.lastname: Fouquet
authors.affiliation: Department of Nuclear Medicine and Radiobiology, Centre d'imagerie moléculaire de Sherbrooke (CIMS), Université de Sherbrooke, Suite 1982, 3001, 12th Avenue North, Sherbrooke, Québec J1H 5N4, Canada.
authors.forename: Réjean
authors.initials: R
authors.lastname: Lebel
authors.affiliation: Department of Nuclear Medicine and Radiobiology, Centre d'imagerie moléculaire de Sherbrooke (CIMS), Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Québec J1H 5N4, Canada. Electronic address: martin.lepage@usherbrooke.ca.
authors.forename: Martin
authors.initials: M
authors.lastname: Lepage
mesh_terms: D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008962:Models, Theoretical; D009068:Movement; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D019786:Gadolinium DTPA
keywords: Arterial input function; Image-derived input function; Input function conversion; Kinetic modeling; MRI; PET