title: Influence of the Surfactant Tyloxapol on Mucociliary Clearance in Human Respiratory Cystic Fibrosis Cells.
abstract: Dehydration of the apical surface of cystic fibrosis (CF) airway epithelia leads to a greatly impaired mucociliary clearance function in CF patients. In an in vitro cell model of human airway epithelia taken from CF patients and cultivated for 60 days, mucociliary clearance was zero. Tyloxapol, a synthetic surfactant, is able to restore the mucociliary clearance of the CF epithelia. The velocity of mucociliary clearance, using polystyrene microbeads as markers, increased within the first minute of tyloxapol treatment from zero to 12 µm/s and reached a maximum of 22 µm/s after 120 min. In conclusion, tyloxapol restores mucociliary clearance in a MucilAir™-CF model and may accordingly be efficient in CF patients to restore mucociliary clearance.
authors.affiliation: Department of Experimental and Clinical Pharmacology, Medical University Graz, Graz, Austria.
authors.forename: Eckhard
authors.initials: E
authors.lastname: Beubler
authors.forename: Rainald
authors.initials: R
authors.lastname: Fischer
authors.forename: Gerald
authors.initials: G
authors.lastname: Untersteiner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Strohmaier
mesh_terms: D003550:Cystic Fibrosis; D006801:Humans; D008863:Microspheres; D009079:Mucociliary Clearance / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011137:Polystyrenes / Q000493:pharmacokinetics*; D020545:Respiratory Mucosa / Q000166:cytology / Q000378:metabolism*; D013501:Surface-Active Agents / Q000494:pharmacology*; D046509:Tissue Culture Techniques
chemical_list: D011137:Polystyrenes; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; C016811:tyloxapol