title: Protein-surface interactions on stimuli-responsive polymeric biomaterials.
abstract: Responsive surfaces: a review of the dependence of protein adsorption on the reversible volume phase transition in stimuli-responsive polymers. Specifically addressed are a widely studied subset: thermoresponsive polymers. Findings are also generalizable to other materials which undergo a similarly reversible volume phase transition. As of 2015, over 100,000 articles have been published on stimuli-responsive polymers and many more on protein-biomaterial interactions. Significantly, fewer than 100 of these have focused specifically on protein interactions with stimuli-responsive polymers. These report a clear trend of increased protein adsorption in the collapsed state compared to the swollen state. This control over protein interactions makes stimuli-responsive polymers highly useful in biomedical applications such as wound repair scaffolds, on-demand drug delivery, and antifouling surfaces. Outstanding questions are whether the protein adsorption is reversible with the volume phase transition and whether there is a time-dependence. A clear understanding of protein interactions with stimuli-responsive polymers will advance theoretical models, experimental results, and biomedical applications.
authors.affiliation: Department of Physics, University of South Florida, Tampa, FL 33620, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Cross
authors.forename: Ryan G
authors.initials: RG
authors.lastname: Toomey
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Gallant
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D044367:Phase Transition; D011108:Polymers / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D011108:Polymers; D011506:Proteins; C052970:poly-N-isopropylacrylamide