title: Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function.
abstract: The central nervous system (CNS) is a highly organised structure. Many signalling systems work in concert to ensure that neural stem cells are appropriately directed to generate progenitor cells, which in turn mature into functional cell types including projection neurons, interneurons, astrocytes, and oligodendrocytes. Herein we explore the role of the low density lipoprotein (LDL) receptor family, in particular family members LRP1 and LRP2, in regulating the behaviour of neural stem and progenitor cells during development and adulthood. The ability of LRP1 and LRP2 to bind a diverse and extensive range of ligands, regulate ligand endocytosis, recruit nonreceptor tyrosine kinases for direct signal transduction and signal in conjunction with other receptors, enables them to modulate many crucial neural cell functions.
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
authors.forename: Loic
authors.identifier: 0000-0002-5017-8101
authors.initials: L
authors.lastname: Auderset
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia; The School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.
authors.forename: Lila M
authors.initials: LM
authors.lastname: Landowski
authors.affiliation: The School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.
authors.forename: Lisa
authors.identifier: 0000-0003-4131-8341
authors.initials: L
authors.lastname: Foa
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
authors.forename: Kaylene M
authors.initials: KM
authors.lastname: Young