title: Targeting TNF alpha as a novel strategy to enhance CD8+T cell-dependent immune response in melanoma?
abstract: Tumor Necrosis Factor α (TNF) is a pleiotropic cytokine exhibiting a dual activity in oncoimmunology, either acting as a cytotoxic effector produced by leukocytes or behaving as an immunosuppressive molecule. We have just discovered that TNF signaling impairs the accumulation of tumor-infiltrating CD8+T lymphocytes in experimental melanoma.
authors.affiliation: INSERM UMR 1037, CRCT, Toulouse, France; Equipe Labellisée Ligue Contre Le Cancer, Toulouse, France.
authors.forename: Florie
authors.initials: F
authors.lastname: Bertrand
authors.affiliation: INSERM UMR 1037, CRCT, Toulouse, France; Equipe Labellisée Ligue Contre Le Cancer, Toulouse, France; Université Toulouse III - Paul Sabatier, Toulouse, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Rochotte
authors.affiliation: INSERM UMR 1037, CRCT, Toulouse, France; Equipe Labellisée Ligue Contre Le Cancer, Toulouse, France; Université Toulouse III - Paul Sabatier, Toulouse, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Colacios
authors.affiliation: INSERM UMR 1037, CRCT, Toulouse, France; Equipe Labellisée Ligue Contre Le Cancer, Toulouse, France; Present affiliation: Queen Mary University, London, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Montfort
authors.affiliation: INSERM UMR 1037, CRCT, Toulouse, France; Equipe Labellisée Ligue Contre Le Cancer, Toulouse, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Andrieu-Abadie
authors.affiliation: INSERM UMR 1037, CRCT, Toulouse, France; Equipe Labellisée Ligue Contre Le Cancer, Toulouse, France; Université Toulouse III - Paul Sabatier, Toulouse, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Levade
authors.affiliation: INSERM UMR 1037, CRCT, Toulouse, France; Equipe Labellisée Ligue Contre Le Cancer, Toulouse, France; Université Toulouse III - Paul Sabatier, Toulouse, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Benoist
authors.affiliation: INSERM UMR 1037, CRCT, Toulouse, France; Equipe Labellisée Ligue Contre Le Cancer, Toulouse, France; Université Toulouse III - Paul Sabatier, Toulouse, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Ségui
keywords: Apoptosis; T lymphocytes; TNF; high endothelial venules; melanoma; tumor-infiltrating CD8+ lymphocytes