title: A single dose of alcohol does not meaningfully alter circadian phase advances and phase delays to light in humans.
abstract: Central circadian timing influences mental and physical health. Research in nocturnal rodents has demonstrated that when alcohol is consumed, it reaches the central hypothalamic circadian pacemaker (suprachiasmatic nuclei) and can directly alter circadian phase shifts to light. In two separate studies, we examined, for the first time, the effects of a single dose of alcohol on circadian phase advances and phase delays to light in humans. Two 23-day within-subjects placebo-controlled counterbalanced design studies were conducted. Both studies consisted of 6 days of fixed baseline sleep to stabilize circadian timing, a 2-day laboratory session, a 6-day break, and a repeat of 6 days of fixed sleep and a 2-day laboratory session. In the phase advance study (n= 10 light drinkers, 24-45 yr), the laboratory sessions consisted of a baseline dim light phase assessment, sleep episode, alcohol (0.6 g/kg) or placebo, 2-h morning bright light pulse, and final phase assessment. In the phase-delay study (n= 14 light drinkers, 22-44 yr), the laboratory sessions consisted of a baseline phase assessment, alcohol (0.8 g/kg) or placebo, 2-h late night bright light pulse, sleep episode, and final phase assessment. In both studies, alcohol either increased or decreased the observed phase shifts to light (interaction P≥ 0.46), but the effect of alcohol vs. placebo on phase shifts to light was always on average smaller than 30 min. Thus, no meaningful effects of a single dose of alcohol vs. placebo on circadian phase shifts to light in humans were observed.
authors.affiliation: Biological Rhythms Research Laboratory, Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois; Helen_J_Burgess@rush.edu.
authors.forename: Helen J
authors.initials: HJ
authors.lastname: Burgess
authors.affiliation: Biological Rhythms Research Laboratory, Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois;
authors.forename: Muneer
authors.initials: M
authors.lastname: Rizvydeen
authors.affiliation: College of Nursing, Rush University Medical Center, Chicago, Illinois; and.
authors.forename: Louis F
authors.initials: LF
authors.lastname: Fogg
authors.affiliation: Department of Digestive Diseases, Rush University Medical Center, Chicago, Illinois.
authors.forename: Ali
authors.initials: A
authors.lastname: Keshavarzian
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000428:Alcohol Drinking; D015415:Biomarkers / Q000097:blood; D002940:Circadian Rhythm / Q000187:drug effects* / Q000528:radiation effects*; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008027:Light; D008297:Male; D008550:Melatonin / Q000097:blood*; D008875:Middle Aged; D010775:Photic Stimulation; D017440:Photoperiod; D012890:Sleep; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D000431:Ethanol; D008550:Melatonin
keywords: alcohol; circadian; human; light; melatonin