title: Cardiometabolic crosstalk in obesity-associated arterial hypertension.
abstract: Abdominal obesity and elevated blood pressure commonly occur in the same patient and are key components of the metabolic syndrome. However, the association between obesity and increased blood pressure is variable. We review mechanisms linking cardiovascular and metabolic disease in such patients including altered systemic and regional hemodynamic control, neurohumoral activation, and relative natriuretic peptide deficiency. Moreover, we discuss recent results using omics techniques providing insight in molecular pathways linking adiposity, metabolic disease, and arterial hypertension. Recognition of the mechanisms orchestrating the crosstalk between cardiovascular and metabolic regulation in individual patients may lead to better and more precise treatments. It is reassuring that recently developed cardiovascular and metabolic medications may in fact ameliorate, both, cardiovascular and metabolic risks.
authors.affiliation: Institute for Clinical Pharmacology, Medical School Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Germany. jordan.jens@mh-hannover.de.
authors.forename: Jens
authors.initials: J
authors.lastname: Jordan
authors.affiliation: Section of Metabolic Vascular Medicine, Medical Clinic III, Dresden University School of Medicine, Dresden, TU, Germany.|Center for Clinical Studies, GWT-TUD GmbH, Dresden, Germany.|Paul Langerhans Institute Dresden (PLID), A Member of the German Center for Diabetes Research (DZD e.V.), Dresden, Germany.
authors.forename: Andreas L
authors.initials: AL
authors.lastname: Birkenfeld
mesh_terms: D015897:Comorbidity; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology
keywords: Hypertension; Individualized medicine; Metabolic syndrome; Natriuretic peptides; Neurohumoral; Obesity