title: Neurolymphomatosis in a cat.
abstract: A 9-year-old male mixed breed cat showed chronic progressive neurological symptoms, which are represented by ataxia and seizures. At necropsy, spinal roots and spinal ganglions at the level of sixth cervical nerve to second thoracic nerve were bilaterally swollen and replaced by white mass lesions. Right brachial plexus and cranial nerves (III, V and VII) were also swollen. A mass lesion was found in the right frontal lobe of the cerebrum. Histologically, neoplastic lymphocytes extensively involved the peripheral nerves, and they infiltrated into the cerebral and spinal parenchyma according to the peripheral nerve tract. Immunohistochemically, most neoplastic lymphocytes were positive for CD20. The clinical and histological features in this case resemble those of neurolymphomatosis in humans.
authors.affiliation: Department of Veterinary Pathology, Yamaguchi University, Yamaguchi, Yamaguchi 753-8511, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Sakurai
authors.forename: Kazushi
authors.initials: K
authors.lastname: Azuma
authors.forename: Arata
authors.initials: A
authors.lastname: Nagai
authors.forename: Toru
authors.initials: T
authors.lastname: Fujioka
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sunden
authors.forename: Akinori
authors.initials: A
authors.lastname: Shimada
authors.forename: Takehito
authors.initials: T
authors.lastname: Morita
mesh_terms: D000818:Animals; D001917:Brachial Plexus / Q000473:pathology; D002371:Cat Diseases / Q000175:diagnosis / Q000473:pathology*; D002415:Cats; D003391:Cranial Nerves / Q000473:pathology; D005625:Frontal Lobe / Q000473:pathology; D005727:Ganglia, Spinal / Q000473:pathology; D008297:Male; D008380:Marek Disease / Q000175:diagnosis / Q000473:pathology*; D013126:Spinal Nerve Roots / Q000473:pathology