title: Demographic and histopathologic profile of pediatric brain tumors: A hospital-based study.
abstract: BACKGROUND
  Very few hospital-based or population-based studies are published in the context to the epidemiologic profile of pediatric brain tumors (PBTs) in India and Indian subcontinent.
  
  
  OBJECTIVE
  To study the demographic and histopathologic profile of PBTs according to World Health Organization 2007 classification in a single tertiary health care center in India.
  
  
  METHODS
  Data regarding age, gender, topography, and histopathology of 76 pediatric patients (0-19 years) with brain tumors operated over a period of 24 months (January-2012 to December-2013) was collected retrospectively and analyzed using EpiInfo 7. Chi-square test and test of proportions (Z-test) were used wherever necessary.
  
  
  RESULTS
  PBTs were more common in males (55.3%) as compared to females (44.7%) with male to female ratio of 1.23:1. Mean age was 10.69 years. Frequency of tumors was higher in childhood age group (65.8%) when compared to adolescent age group (34.2%). The most common anatomical site was cerebellum (39.5%), followed by hemispheres (22.4%). Supratentorial tumors (52.6%) were predominant than infratentorial tumors (47.4%). Astrocytomas (40.8%) and embryonal tumors (29.0%) were the most common histological types almost contributing more than 2/3(rd) of all tumors. Craniopharyngiomas (11.8%) and ependymomas (6.6%) were the third and fourth most common tumors, respectively.
  
  
  CONCLUSIONS
  Astrocytomas and medulloblastomas are the most common tumors among children and adolescents in our region, which needs special attention from the neurosurgical department of our institute. Demographic and histopathologic profile of cohort in the present study do not differ substantially from that found in other hospital-based and population-based studies except for slight higher frequency of craniopharyngiomas.
authors.affiliation: Department of Neurosurgery, B. J. Medical College and Civil Hospital, Ahmedabad, Gujarat, India.
authors.forename: Harshil C
authors.initials: HC
authors.lastname: Shah
authors.affiliation: Department of Neurosurgery, B. J. Medical College and Civil Hospital, Ahmedabad, Gujarat, India.
authors.forename: Bhushan P
authors.initials: BP
authors.lastname: Ubhale
authors.affiliation: Department of Neurosurgery, B. J. Medical College and Civil Hospital, Ahmedabad, Gujarat, India.
authors.forename: Jaimin K
authors.initials: JK
authors.lastname: Shah
keywords: Astocytomas; World Health Organization; cerebellum; epidemiologic profile; supratentorial tumors