title: Arsenic methylation and skin lesions in migrant and native adult women with chronic exposure to arsenic from drinking groundwater.
abstract: In order to figure out the prevalence of skin lesions and methylation capacity for migrant and native adult women in an endemic area for arsenic poisoning in Inner Mongolia, China, 207 adult women were selected for study subjects. The results showed that the prevalence of skin lesions for the external group, provincial group and native group was 36.54, 26.15 and 35.56 %, respectively. The nail content of arsenic and urinary concentrations of dimethylarsenic (DMA), monomethylarsenic (MMA) and inorganic arsenic (iAs) were significantly higher in women with skin lesions than in those without skin lesions. The highest urinary concentrations of DMA, MMA and iAs were 213.93, 45.72 and 45.01 μg/L in the native group. The arsenic methylation capacity index revealed that the external group had the greatest capacity, while the native group had the lowest. The odds ratios of skin lesions in relation to arsenic metabolites and arsenic methylation capacity varied widely among the three groups. Urinary MMA and iAs concentrations were positively associated with risk of skin lesions in the three groups of adult women, while primary and secondary methylation capacities were negatively related to risk of skin lesions in native and provincial groups. The external group might be more susceptible to MMA and iAs, while the provincial and native groups were more tolerance to MMA and iAs. Lower primary and secondary arsenic methylation capacities increased the risk of skin lesions in native and provincial groups. Moreover, higher nail arsenic concentration increased the risk of skin lesions of adult women.
authors.affiliation: Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, Beijing, 100101, China.
authors.forename: Binggan
authors.initials: B
authors.lastname: Wei
authors.affiliation: Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, Beijing, 100101, China.
authors.forename: Jiangping
authors.initials: J
authors.lastname: Yu
authors.affiliation: Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, Beijing, 100101, China. yangls@igsnrr.ac.cn.
authors.forename: Linsheng
authors.initials: L
authors.lastname: Yang
authors.affiliation: Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, Beijing, 100101, China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, Beijing, 100101, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Chai
authors.affiliation: Inner Mongolia Center for Endemic Disease Control and Research, Huhhot, Inner Mongolia, China.
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Inner Mongolia Center for Endemic Disease Control and Research, Huhhot, Inner Mongolia, China.
authors.forename: Kegong
authors.initials: K
authors.lastname: Wu
authors.affiliation: Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, Beijing, 100101, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Gao
authors.affiliation: Inner Mongolia Center for Endemic Disease Control and Research, Huhhot, Inner Mongolia, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Inner Mongolia Center for Endemic Disease Control and Research, Huhhot, Inner Mongolia, China.
authors.forename: Na
authors.initials: N
authors.lastname: Cui
mesh_terms: D000328:Adult; D001151:Arsenic / Q000633:toxicity* / Q000652:urine; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008745:Methylation; D015995:Prevalence; D012871:Skin Diseases / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D001151:Arsenic
keywords: Adult women; Arsenic; Drinking water; Skin lesion methylation capacity