title: Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy-Induced Nausea and Vomiting in Children With Cancer.
abstract: This clinical practice guideline provides an approach to the treatment of breakthrough chemotherapy-induced nausea and vomiting (CINV) and the prevention of refractory CINV in children. It was developed by an international, interprofessional panel and is based on systematic literature reviews. Evidence-based interventions for the treatment of breakthrough and prophylaxis of refractory CINV are recommended. Gaps in the evidence used to support the recommendations made in this clinical practice guideline were identified. The contribution of these recommendations to breakthrough and refractory CINV control in children requires prospective evaluation.
authors.affiliation: Department of Pharmacy, The Hospital for Sick Children, Toronto, Canada.|Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Flank
authors.affiliation: Pediatric Oncology Group of Ontario, Toronto, Canada.
authors.forename: Paula D
authors.initials: PD
authors.lastname: Robinson
authors.affiliation: College of Pharmacy, University of New Mexico, Albuquerque, New Mexico.
authors.forename: Mark
authors.initials: M
authors.lastname: Holdsworth
authors.affiliation: Regional Department of Haematology and Oncology, Leeds Children's Hospital, Leeds, United Kingdom.|Centre for Reviews and Dissemination, University of York, York, United Kingdom.
authors.forename: Robert
authors.initials: R
authors.lastname: Phillips
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, McMaster University, Hamilton, Canada.
authors.forename: Carol
authors.initials: C
authors.lastname: Portwine
authors.affiliation: Pediatric Hematology/Oncology, Children's Hospital, London Health Sciences Centre, London, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Gibson
authors.affiliation: Pediatric Hematology/Oncology, Children's Hospital, London Health Sciences Centre, London, Canada.
authors.forename: Cathy
authors.initials: C
authors.lastname: Maan
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, McMaster University, Hamilton, Canada.
authors.forename: Nancy
authors.initials: N
authors.lastname: Stefin
authors.affiliation: Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada.|Research Institute, The Hospital for Sick Children, Toronto, Canada.
authors.forename: Lillian
authors.initials: L
authors.lastname: Sung
authors.affiliation: Department of Pharmacy, The Hospital for Sick Children, Toronto, Canada.|Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.|Research Institute, The Hospital for Sick Children, Toronto, Canada.
authors.forename: L Lee
authors.initials: LL
authors.lastname: Dupuis
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009325:Nausea / Q000209:etiology / Q000517:prevention & control*; D009369:Neoplasms / Q000628:therapy*; D017410:Practice Guidelines as Topic; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control*
keywords: chemotherapy-induced nausea; chemotherapy-induced vomiting; clinical practice guideline; supportive care