title: History of ABVD alters the number of oocytes vitrified after in vitro maturation in fertility preservation candidates.
abstract: OBJECTIVE
  This retrospective case-control study aimed at analyzing the results of in vitro maturation (IVM) of oocytes, used for fertility preservation (FP), in patients with history of ABVD (adriamycin, bleomycin, vinblastine and dacarbazine) for classical Hodgkin lymphoma.
  
  
  METHODS
  A total of 22 candidates for FP, having received ABVD at least 2 years before IVM for FP were studied. IVM results were compared with those of 44 breast cancer patients, without history of chemotherapy, matched for ovarian reserve parameters.
  
  
  RESULTS
  The number of cumulo-oocyte complexes recovered and the total number of matured oocytes vitrified was lower in patients having received AVBD (5.5 ± 4.8 vs 8.5 ± 4.4 oocytes; p = 0.03 and 3.5 ± 3.7 vs 6 ± 3.0 oocytes; p < 0.04, respectively).
  
  
  CONCLUSIONS
  In light of these results, FP should be discussed before ABVD.
authors.affiliation: Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Jean-Verdier, Avenue du 14 Juillet, 93140 Bondy, France.|Université Paris XIII, 93000 Bobigny, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Sonigo
authors.affiliation: Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Jean-Verdier, Avenue du 14 Juillet, 93140 Bondy, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Seroka
authors.affiliation: Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Jean-Verdier, Avenue du 14 Juillet, 93140 Bondy, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Cédrin-Durnerin
authors.affiliation: Service de Cytogénétique et Biologie de la Reproduction, Hôpital Jean-Verdier, Avenue du 14 Juillet, 93140 Bondy, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Sermondade
authors.affiliation: Service de Cytogénétique et Biologie de la Reproduction, Hôpital Jean-Verdier, Avenue du 14 Juillet, 93140 Bondy, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Sifer
authors.affiliation: Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Jean-Verdier, Avenue du 14 Juillet, 93140 Bondy, France.|Université Paris XIII, 93000 Bobigny, France.|Unité Inserm U1133, Université Paris-Diderot, 75013 Paris, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Grynberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects; D016022:Case-Control Studies; D003606:Dacarbazine / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects; D005260:Female; D059247:Fertility Preservation; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D009865:Oocytes / Q000187:drug effects*; D012189:Retrospective Studies; D014747:Vinblastine / Q000009:adverse effects; D058989:Vitrification; D055815:Young Adult
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin
keywords: ABVD; Hodgkin lymphoma; fertility preservation