title: The Effect of Preoperative Oral Immunonutrition on Complications and Length of Hospital Stay After Elective Surgery for Pancreatic Cancer--A Randomized Controlled Trial.
abstract: Major gastrointestinal surgery is associated with immune suppression and a high risk of postoperative complications. The aim of this open, randomized controlled trial was to examine the effect of supplementary per oral immunonutrition (IN) seven days before surgery for pancreatic cancer (PC) on postoperative complications and length of hospital stay (LOS). Secondary outcomes were the changes in functional capability and body weight (BW). Consecutive patients referred for surgery for diagnosed or plausible PC were included. The patients in the intervention group received supplementary IN (Oral Impact®, Nestlé) to reach a goal of 1.5 g protein/kg BW. The control group continued their habitual diet. Complications and LOS were independently assessed by the surgical staff. Secondary outcomes were measured 10, 20, and 30 days postoperatively. Thirty-five patients were included, of whom 19 (54%) were allocated to the intervention group. The doses of IN ranged from 250 to 1000 ml per day and the median compliance was 100 (0-100%). Based on the principle of intention-to-treat, no significant differences were found between the groups. We conclude that the lack of effect could be due to the limited dosage of IN, and/or because only 40% of the patients were at nutritional risk.
authors.affiliation: a Department of Nutrition, Exercise and Sports , University of Copenhagen , Copenhagen , Denmark.
authors.forename: Josephine
authors.initials: J
authors.lastname: Gade
authors.affiliation: a Department of Nutrition, Exercise and Sports , University of Copenhagen , Copenhagen , Denmark.|b Department of Medical Hepatology and Gastroenterology V , Aarhus University Hospital , Aarhus , Denmark.
authors.forename: Trine
authors.initials: T
authors.lastname: Levring
authors.affiliation: c Department of Surgical Gastroenterology , Rigshospitalet , Copenhagen , Denmark.
authors.forename: Jens
authors.initials: J
authors.lastname: Hillingsø
authors.affiliation: c Department of Surgical Gastroenterology , Rigshospitalet , Copenhagen , Denmark.
authors.forename: Carsten Palnæs
authors.initials: CP
authors.lastname: Hansen
authors.affiliation: a Department of Nutrition, Exercise and Sports , University of Copenhagen , Copenhagen , Denmark.|d Nutrition Unit 5711, Rigshospitalet , Copenhagen , Denmark.
authors.forename: Jens Rikardt
authors.initials: JR
authors.lastname: Andersen
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D001835:Body Weight; D017558:Elective Surgical Procedures / Q000009:adverse effects; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000009:adverse effects / Q000379:methods; D010190:Pancreatic Neoplasms / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology*; D011300:Preoperative Care