title: Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review.
abstract: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease which represents a wide spectrum of hepatic damage. Several studies have reported that NAFLD is a strong independent risk factor for coronary artery disease (CAD). And patients with NAFLD are at higher risk and suggested undergoperiodic cardiovascular risk assessment. Cardiovascular disease (CVD) is responsible for the main cause of death in patients with NAFLD, and is mostly influenced by genetic factors. Both NAFLD and CAD are heterogeneous disease. Common pathways involved in the pathogenesis of NAFLD and CAD includes insulin resistance (IR), atherogenic dyslipidemia, subclinical inflammation, oxidative stress, etc. Genomic characteristics of these two diseases have been widely studied, further research about the association of these two diseases draws attention. The gene polymorphisms of adiponectin-encoding gene (ADIPOQ), leptin receptor (LEPR), apolipoprotein C3 (APOC3), peroxisome proliferator-activated receptors (PPAR), sterol regulatory elementbinding proteins (SREBP), transmembrane 6 superfamily member 2 (TM6SF2), microsomal triglyceride transfer protein (MTTP), tumor necrosis factors-alpha (TNF-α) and manganese superoxide dismutase (MnSOD) have been reported to be related to NAFLD and CAD. In this review, we aimed to provide an overview of recent insights into the genetic basis of NAFLD and CAD.
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, 266011, China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, 266011, China.
authors.forename: Jian-Qing
authors.initials: JQ
authors.lastname: Sui
authors.affiliation: Digestive Disease Key Laboratory of Qingdao, Qingdao, 266071, China.|Central Laboratories, Qingdao Municipal Hospital, Qingdao, 266071, China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Lu
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, 266011, China.
authors.forename: Nan-Nan
authors.initials: NN
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, 266011, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, 266011, China.
authors.forename: Quan-Yong
authors.initials: QY
authors.lastname: Dong
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, 266011, China. xinyongning@163.com.|Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, 266011, China. xinyongning@163.com.|Digestive Disease Key Laboratory of Qingdao, Qingdao, 266071, China. xinyongning@163.com.
authors.forename: Yong-Ning
authors.initials: YN
authors.lastname: Xin
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, 266011, China. xuansydxy@163.com.|Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, 266011, China. xuansydxy@163.com.|Digestive Disease Key Laboratory of Qingdao, Qingdao, 266071, China. xuansydxy@163.com.
authors.forename: Shi-Ying
authors.initials: SY
authors.lastname: Xuan
mesh_terms: D052242:Adiponectin / Q000235:genetics; D053305:Apolipoprotein C-III / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D003324:Coronary Artery Disease / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D065626:Non-alcoholic Fatty Liver Disease / Q000235:genetics*; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics; D011110:Polymorphism, Genetic; D054411:Receptors, Leptin / Q000235:genetics; D051779:Sterol Regulatory Element Binding Proteins / Q000235:genetics; D013482:Superoxide Dismutase / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D000099156:Superoxide Dismutase 2
chemical_list: D052242:Adiponectin; D053305:Apolipoprotein C-III; D002352:Carrier Proteins; D008565:Membrane Proteins; D047492:Peroxisome Proliferator-Activated Receptors; D054411:Receptors, Leptin; D051779:Sterol Regulatory Element Binding Proteins; D013482:Superoxide Dismutase; D014409:Tumor Necrosis Factor-alpha; D000099156:Superoxide Dismutase 2; C499918:ADIPOQ protein, human; C515448:LEPR protein, human; C419195:TM6SF2 protein, human; C106092:microsomal triglyceride transfer protein
keywords: Coronary artery disease; Gene pathogenesis; Genetic polymorphisms; Non-alcoholic fatty liver disease