title: [THE ROLE OF BIFIDOBACTERIA IN THE FORMATION OF HUMAN IMMUNE HOMEOSTASIS].
abstract: In the review the materials on the formation of intestinal immune homeostasis through involvement of bifidobacteria which are the key species of microbiota of human colon biotype are presented. Key function of dominant microorganisms, bifidoflora in particular, in intestinal biotype of a host is carried out by means of maintenance of self microorganisms and pronounced antagonism concerning non-self. Realization of this principle in intermicrobial relations allowed to develop algorithm of microbial self-non-self discrimination in microsymbiocenosis on the basis of detected opposite phenomenon (enhancement/suppression) of the main physiological functions of microsymbionts survival (reproduction and adaptation) in dominant-associant pair. Primary discrimination of foreign,material by bifidobacteria is the initial stage of the following "signaling" in the regulation of host immune homeostasis. Further stages of regulation occur by activation of dendritic cells by bifidobacteria with the sequential influence on differentiation of Th0 towards regulatory lymphocytes. The formation of Treg and regulation of immune homeostasis are carried out by bifidobacteria: due to direct activation of dendritic cells (ligand-receptor interactions) and maintenance of optimal cytokine balance.
authors.forename: O V
authors.initials: OV
authors.lastname: Bukharin
authors.forename: E V
authors.initials: EV
authors.lastname: Ivanova
authors.forename: N B
authors.initials: NB
authors.lastname: Perunova
authors.forename: I N
authors.initials: IN
authors.lastname: Chainikova
mesh_terms: D001644:Bifidobacterium / Q000276:immunology*; D003106:Colon / Q000276:immunology / Q000382:microbiology; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology / Q000382:microbiology; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D064307:Microbiota / Q000276:immunology*; D015398:Signal Transduction; D013559:Symbiosis / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000382:microbiology; D058408:Th1-Th2 Balance
chemical_list: D016207:Cytokines