title: Steroidal Saponins from the Rhizomes of Aspidistra typica.
abstract: Eleven new furostanol saponins, typaspidosides B-L (1-11), one new spirostanol saponin, typaspidoside M (12), and five known spirostanol saponins, 25S-atropuroside (13), neoaspidistrin (14), (25S)-pratioside D1 (15), 25S-aspidistrin (16) and 25S-neosibiricoside (17) were isolated from the rhizomes of Aspidistra typica Baill. The structures of the new compounds were established using 1D and 2D NMR (1H-1H COSY, HMQC, HMBC and ROESY) spectroscopy, high resolution mass spectrometry, and chemical methods. The aglycones of 1-3 (unusual furostanol saponins with opened E ring type), 9 and 10 (the methoxyl substituent at C-23 position) were found, identified from natural products for the first time. Moreover, the anti-HIV activities of the isolated steroidal glycosides were assessed, and compounds 13, 14, 16 and 17 exhibited high active against HIV-1.
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.|School of Pharmaceutical Sciences, Central South University, Changsha, 410013, China.
authors.forename: Jiang-Ming
authors.initials: JM
authors.lastname: Cui
authors.affiliation: State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Kang
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
authors.forename: Jian-Yuan
authors.initials: JY
authors.lastname: Zhao
authors.affiliation: Ovation Health Science and Technology Co. Ltd., ENN Group, Langfang, 065001, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Pang
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.
authors.forename: He-Shui
authors.initials: HS
authors.lastname: Yu
authors.affiliation: Ovation Health Science and Technology Co. Ltd., ENN Group, Langfang, 065001, China.
authors.forename: De-Xian
authors.initials: DX
authors.lastname: Jia
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Yu
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.
authors.forename: Bai-Ping
authors.initials: BP
authors.lastname: Ma
mesh_terms: D019380:Anti-HIV Agents / Q000302:isolation & purification / Q000494:pharmacology*; D036022:Capsid Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D017930:Genes, Reporter; D057809:HEK293 Cells; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D006801:Humans; D019668:Liliaceae / Q000737:chemistry*; D008156:Luciferases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D016865:Reassortant Viruses / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D027343:Rhizome / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D013150:Spirostans / Q000302:isolation & purification / Q000494:pharmacology; D013256:Steroids / Q000302:isolation & purification / Q000494:pharmacology; D013261:Sterols / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D018116:Vesiculovirus / Q000235:genetics; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D036022:Capsid Proteins; D010936:Plant Extracts; D012503:Saponins; D013150:Spirostans; D013256:Steroids; D013261:Sterols; C521858:furostanol saponin I; C582534:typaspidoside A; D008156:Luciferases