title: Acute monoblastic leukemia with abnormal eosinophils and inversion (16): A rare entity.
abstract: Acute myeloid leukemia (AML) is a malignant hematopoietic stem cell disorder which is sub-classified based on bone marrow morphology and the presence of specific genetic abnormalities. One such cytogenetic abnormality is the pericentric inversion (inv) of chromosome 16 which is typically seen in AML M4 with eosinophilia and is associated with a favorable prognosis. We report the inv (16) in a young woman with AML M5 and abnormal eosinophils. This is a rare entity with only about 20 cases being reported till date.
authors.forename: Kiruthiga Kala
authors.initials: KK
authors.lastname: Gnanasekaran
authors.affiliation: Department of Transfusion Medicine and Immunohematology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Mary P
authors.initials: MP
authors.lastname: Chacko
authors.forename: Marie Therese
authors.initials: MT
authors.lastname: Manipadam
authors.forename: M S
authors.initials: MS
authors.lastname: Bindra
authors.forename: Biju
authors.initials: B
authors.lastname: George
authors.forename: Vivi M
authors.initials: VM
authors.lastname: Srivastava
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000175:diagnosis* / Q000473:pathology*; D008853:Microscopy
chemical_list: D014408:Biomarkers, Tumor