title: Iron-mediated inter- and intramolecular reductive cross-coupling of unactivated alkyl chlorides with aryl bromides.
abstract: An efficient one-pot intermolecular reductive cross-coupling of unactivated primary and secondary alkyl chlorides bearing β-hydrogens with aryl bromides is described. A combination of magnesium turnings and a catalytic amount of the commercially available iron(iii) complex Fe(PPh3)2Cl3 was used, and the conditions were also successfully extended to an intramolecular reaction for the first time. Both types of cross-coupling reactions proceed under mild conditions, involving the in situ generation of aryl Grignard reagents, and show good applicability to a variety of readily available unactivated alkyl chlorides, which have previously been challenging substrates in iron-catalyzed reductive cross-coupling reactions.
authors.affiliation: The Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China. sunhm@suda.edu.cn.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Li
authors.affiliation: The Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China. sunhm@suda.edu.cn.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Sun
authors.affiliation: The Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China. sunhm@suda.edu.cn.
authors.forename: Qi
authors.initials: Q
authors.lastname: Shen