title: Infertility and recurrent miscarriage with complex II deficiency-dependent mitochondrial oxidative stress in animal models.
abstract: Oxidative stress is associated with some forms of both male and female infertility. However, there is insufficient knowledge of the influence of oxidative stress on the maintenance of a viable pregnancy, including pregnancy complications and fetal development. There are a number of animal models for understanding age-dependent decrease of reproductive ability and diabetic embryopathy, especially abnormal spermatogenesis, oogenesis and embryogenesis with mitochondrial dysfunctions. Several important processes occur in mitochondria, including ATP synthesis, calcium ion storage, induction of apoptosis and production of reactive oxygen species (ROS). These events have different effects on the several aspects of reproductive function. Tet-mev-1 conditional transgenic mice, developed after studies with the mev-1 mutant of the nematode C. elegans, offer the ability to carefully regulate expression of doxycycline-induced mutated SDHC(V69E) levels and hence modulate endogenous oxidative stress. The mev-1 models have served to illuminate the effects of complex II deficiency-dependent mitochondrial ROS production, although interestingly they maintain normal mitochondrial and intracellular ATP levels. In this review, the reproductive dysfunctions are presented focusing on fertility potentials in each gamete, early embryogenesis, maternal conditions with placental function and neonatal development.
authors.affiliation: Department of Molecular Life Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan; Institute of Medical Sciences, Tokai University, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. Electronic address: ishiit@tokai.ac.jp.
authors.forename: Takamasa
authors.initials: T
authors.lastname: Ishii
authors.affiliation: Department of Molecular Life Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan; Support Center for Medical Research and Education, Tokai University, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Kayo
authors.initials: K
authors.lastname: Yasuda
authors.affiliation: Department of Biological Sciences, North Carolina State University, Box 7633, Raleigh, NC 27695, USA.
authors.forename: Masaki
authors.initials: M
authors.lastname: Miyazawa
authors.affiliation: Department of Obstetrics and Gynecology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya, Saitama 330-8503, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Mitsushita
authors.affiliation: Institute for Behavioral Genetics, University of Colorado, Box 447, Boulder, CO 80303, USA.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Johnson
authors.affiliation: Department of Biology, Texas Christian University, Fort Worth, TX 76129, USA.
authors.forename: Phil S
authors.initials: PS
authors.lastname: Hartman
authors.affiliation: Department of Molecular Life Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Naoaki
authors.initials: N
authors.lastname: Ishii
mesh_terms: D000022:Abortion, Spontaneous / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology / Q000235:genetics; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D042963:Electron Transport Complex II / Q000172:deficiency*; D005260:Female; D006801:Humans; D007246:Infertility / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D018384:Oxidative Stress; D011247:Pregnancy; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; D017382:Reactive Oxygen Species; D042963:Electron Transport Complex II
keywords: Embryopathy; Infertility; Miscarriage; Mitochondria; Oxidative stress; SDHC