title: Prophylactic use of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia: a randomized, double-blinded, placebo-controlled study.
abstract: BACKGROUND
  Succinylcholine is commonly used to achieve profound neuromuscular blockade of rapid onset and short duration.
  
  
  OBJECTIVE
  The present study compared the efficacy of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia.
  
  
  METHODS
  Prospective, randomized, placebo controlled, double blinded study.
  
  
  METHODS
  Patients of both genders undergoing elective spine surgery were randomly assigned to two groups. Patients in Group P (pregabalin group) received 150mg of pregabalin orally 1h prior to induction of anesthesia with sips of water and patients in Group C (control group) received placebo. Anesthesia was induced with fentanyl 1.5mcg/kg, propofol 1.5-2.0mg/kg followed by succinylcholine 1.5mg/kg. The intensity of fasciculations was assessed by an observer blinded to the group allotment of the patient on a 4-point scale. A blinded observer recorded postoperative myalgia grade after 24h of surgery. Patients were provided patient-controlled analgesia with fentanyl for postoperative pain relief.
  
  
  RESULTS
  Demographic data of both groups were comparable (p>0.05). The incidence of muscle fasciculation's was not significant between two groups (p=0.707), while more patients in group C had moderate to severe fasciculation's compared to group P (p=0.028). The incidence and severity of myalgia were significantly lower in group P (p<0.05).
  
  
  CONCLUSIONS
  Pregabalin 150mg prevents succinylcholine-induced fasciculations and myalgia and also decreases the fentanyl consumption in elective sine surgery.
authors.affiliation: Apollo Hospitals Bilaspur, Chhattisgarh, India. Electronic address: drvinit75@gmail.com.
authors.forename: Vinit K
authors.initials: VK
authors.lastname: Srivastava
authors.affiliation: Himalayan Institute of Medical Sciences, Dehradun, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Agrawal
authors.affiliation: Apollo Hospitals Bilaspur, Chhattisgarh, India.
authors.forename: Vikrant K
authors.initials: VK
authors.lastname: Nimbhorkar
authors.affiliation: Apollo Hospitals Bilaspur, Chhattisgarh, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Mishra
authors.affiliation: Apollo Hospitals Bilaspur, Chhattisgarh, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Apollo Hospitals Bilaspur, Chhattisgarh, India.
authors.forename: Prasanta K
authors.initials: PK
authors.lastname: Panda
mesh_terms: D000328:Adult; D016058:Analgesia, Patient-Controlled / Q000379:methods; D004311:Double-Blind Method; D017558:Elective Surgical Procedures / Q000379:methods; D005207:Fasciculation / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D063806:Myalgia / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D000069583:Pregabalin / Q000627:therapeutic use*; D015742:Propofol / Q000008:administration & dosage; D011446:Prospective Studies; D013131:Spine / Q000601:surgery; D013390:Succinylcholine / Q000008:administration & dosage* / Q000009:adverse effects; D055815:Young Adult
chemical_list: D000069583:Pregabalin; D013390:Succinylcholine; D005283:Fentanyl; D015742:Propofol
keywords: Fasciculation; Fasciculação; Mialgia; Myalgia; Pregabalin; Pregabalina; Succinilcolina; Succinylcholine