title: Social dysfunction after pediatric traumatic brain injury: A translational perspective.
abstract: Social dysfunction is common after traumatic brain injury (TBI), contributing to reduced quality of life for survivors. Factors which influence the development or persistence of social deficits after injury remain poorly understood, particularly in the context of ongoing brain maturation during childhood and adolescence. Aberrant social interactions have recently been modeled in adult and juvenile rodents after experimental TBI, providing an opportunity to gain new insights into the underlying neurobiology of these behaviors. Here, we review our current understanding of social dysfunction in both humans and rodent models of TBI, with a focus on brain injuries acquired during early development. Modulators of social outcomes are discussed, including injury-related and environmental risk and resilience factors. Disruption of social brain network connectivity and aberrant neuroendocrine function are identified as potential mechanisms of social impairments after pediatric TBI. Throughout, we highlight the overlap and disparities between outcome measures and findings from clinical and experimental approaches, and explore the translational potential of future research to prevent or ameliorate social dysfunction after childhood TBI.
authors.affiliation: Australian Centre for Child Neuropsychological Studies, Murdoch Childrens Research Institute, Parkville, VIC, Australia; Melbourne School of Psychological Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia. Electronic address: nicholas.ryan@mcri.edu.au.
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Ryan
authors.affiliation: Australian Centre for Child Neuropsychological Studies, Murdoch Childrens Research Institute, Parkville, VIC, Australia; Melbourne School of Psychological Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia; Department of Psychology, Royal Children's Hospital, Parkville, VIC, Australia. Electronic address: cathy.catroppa@mcri.edu.au.
authors.forename: Cathy
authors.initials: C
authors.lastname: Catroppa
authors.affiliation: Australian Centre for Child Neuropsychological Studies, Murdoch Childrens Research Institute, Parkville, VIC, Australia. Electronic address: celia.godfrey@mcri.edu.au.
authors.forename: Celia
authors.initials: C
authors.lastname: Godfrey
authors.affiliation: Departments of Neurological Surgery and Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA, USA. Electronic address: linda.noble@ucsf.edu.
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Noble-Haeusslein
authors.affiliation: Department of Medicine (Royal Melbourne Hospital), The University of Melbourne, Parkville, VIC, Australia. Electronic address: sandy.shultz@unimelb.edu.au.
authors.forename: Sandy R
authors.initials: SR
authors.lastname: Shultz
authors.affiliation: Department of Medicine (Royal Melbourne Hospital), The University of Melbourne, Parkville, VIC, Australia. Electronic address: obrientj@unimelb.edu.au.
authors.forename: Terence J
authors.initials: TJ
authors.lastname: O'Brien
authors.affiliation: Australian Centre for Child Neuropsychological Studies, Murdoch Childrens Research Institute, Parkville, VIC, Australia; Melbourne School of Psychological Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia; Department of Psychology, Royal Children's Hospital, Parkville, VIC, Australia. Electronic address: vicki.anderson@rch.org.au.
authors.forename: Vicki
authors.initials: V
authors.lastname: Anderson
authors.affiliation: Department of Medicine (Royal Melbourne Hospital), The University of Melbourne, Parkville, VIC, Australia. Electronic address: Bridgette.Semple@unimelb.edu.au.
authors.forename: Bridgette D
authors.initials: BD
authors.lastname: Semple
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology; D000070642:Brain Injuries, Traumatic / Q000503:physiopathology / Q000523:psychology*; D002648:Child; D006801:Humans; D012919:Social Behavior
keywords: Behavior; Brain; Children; Communication; Humans; Pediatric; Rodents; Social brain network; Social competency; Social interactions; Traumatic brain injury