title: Coombs-negative Autoimmune Hemolytic Anemia Followed by Anti-erythropoetin Receptor Antibody-associated Pure Red Cell Aplasia: A Case Report and Review of Literature.
abstract: A 76-year-old woman was referred to our hospital because of anemia. The laboratory findings revealed hemolysis. Although a direct Coombs test was negative, a high titer of RBC-bound IgG was detected, and a diagnosis of Coombs-negative autoimmune hemolytic anemia was made. She was successfully treated with prednisolone. One year and five months later, she again presented anemia and was diagnosed with pure red cell aplasia. Anti-erythropoietin receptor antibody was detected in the serum. She was treated with cyclosporine and obtained prompt recovery. We herein report this rare case and review the pertinent literature.
authors.affiliation: Department of Hematology, Mitsui Memorial Hospital, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Yoshimi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kadowaki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D003298:Coombs Test; D016572:Cyclosporine / Q000627:therapeutic use*; D004921:Erythropoietin; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D017467:Receptors, Erythropoietin / Q000037:antagonists & inhibitors*; D012010:Red-Cell Aplasia, Pure / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D017467:Receptors, Erythropoietin; D004921:Erythropoietin; D016572:Cyclosporine; D011239:Prednisolone