title: Tumor recurrence and tumor-related mortality in endometrial cancer: Analysis in 276 patients.
abstract: BACKGROUND
  In this manuscript, we assessed tumor recurrence and tumor-related mortality in a clinical series of endometrial cancer patients.
  
  
  METHODS
  A retrospective evaluation of 276 patients (mean age 64 years) with histologically confirmed endometrial cancer treated at a single hospital in Madrid (Spain) was conducted. The median follow-up was estimated using the inverse Kaplan-Meier method.
  
  
  RESULTS
  Salient findings were endometrioid carcinoma (84.8% of cases), grade G1 (48.9%) and stages IB (35.1%) and IC (23.2%). Myometrial infiltration >50% was documented in 31.2% of cases and lymphovascular space invasion in 11.9%. After surgery, 52.5% of patients were classified into the low risk group, 21.4% into the intermediate risk group and 26.1% into the high risk group. Tumor recurrence occurred in 14.5% of patients, with an estimated median follow-up of 45 months (95% confidence interval (CI): 41.2-48.8), locoregional recurrence in 42.5% and distant recurrences in 57.5%. Furthermore, 40% of tumor recurrences developed during the first year after primary treatment and 90% over the first 3 years of follow-up. The tumor-related mortality rate was 15.9%. The estimated median follow-up was 46 months (95% CI: 43.0-49.0). Furthermore, 5.07% of death because of tumor developed during the first year after primary treatment and 13.77% over the first 3 years of follow-up.
  
  
  CONCLUSIONS
  The rates of tumor-related death and tumor recurrence in endometrial cancer patients are low, with the highest percentages occurring within 3 years of primary treatment. Most of the recurrences occur outside the pelvis.
authors.forename: A
authors.initials: A
authors.lastname: Tejerizo-García
authors.forename: C
authors.initials: C
authors.lastname: Álvarez-Conejo
authors.forename: L
authors.initials: L
authors.lastname: Muñoz-Hernando
authors.forename: C
authors.initials: C
authors.lastname: Guillén-Gámez
authors.forename: J M
authors.initials: JM
authors.lastname: Seoane-Ruiz
authors.forename: C
authors.initials: C
authors.lastname: Pérez-Sagaseta
authors.affiliation: Department of Obstetrics and Gynecology, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: J S
authors.initials: JS
authors.lastname: Jiménez-López
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D016019:Survival Analysis