title: Type D lymphomatoid papulosis simulating aggressive epidermotropic cytotoxic lymphoma.
abstract: Three histological subtypes of lymphomatoid papulosis (LyP), type A (histiocytic), type B (mycosis fungoides like) and type C (anaplastic large cell lymphoma like) are well recognized. Two new histological variants, type D (simulating an aggressive epidermotropic cytotoxic lymphoma) and type E (angioinvasive type) has been described recently. We describe a 27-year-old man presented with a history of asymptomatic erythematous papules on both upper and lower limbs noted since 10 years of age. There were no systemic symptoms. Biopsy revealed an atypical dermal lymphoid infiltrate with epidermotropism, and the immunohistochemical markers showed a diffuse positivity for CD3, CD8, CD56, T1A and granzyme B with the focal positivity of CD30. All other relevant tests were normal. In this case report of a recently described delineated variant of LyP we emphasize the indolent course of this entity although the histology would suggest a more aggressive disease.
authors.forename: Venkatraman
authors.initials: V
authors.lastname: Mani
authors.affiliation: Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Renu
authors.initials: R
authors.lastname: George
authors.forename: Kavita
authors.initials: K
authors.lastname: Vijayakumar
authors.forename: Sheila
authors.initials: S
authors.lastname: Nair
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D053804:Granzymes / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000175:diagnosis* / Q000473:pathology*; D017731:Lymphomatoid Papulosis / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008853:Microscopy; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D053804:Granzymes