title: Retreatment with aromatase inhibitor therapy in the management of granulosa cell tumor.
abstract: •Over 90% of granulosa cell tumors have a FOXL2 mutation that contributes to aromatase upregulation.•Chemotherapy has demonstrated limited efficacy in the treatment of granulosa cell tumors.•A patient with recurrent granulosa cell tumor responded briefly to anastrazole treatment.•Retreatment with another aromatase inhibitor letrozole led to a durable response of 24 months.
authors.affiliation: Department of Obstetrics & Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, 1695 Eastchester Road, Suite 601, Bronx, NY 10461, United States.
authors.forename: Melissa
authors.initials: M
authors.lastname: Schwartz
authors.affiliation: Department of Obstetrics & Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, 1695 Eastchester Road, Suite 601, Bronx, NY 10461, United States.
authors.forename: Gloria S
authors.initials: GS
authors.lastname: Huang
keywords: Adult granulosa cell tumor of the ovary; Antineoplastic hormonal agents; Aromatase inhibitors; FOXL2; Letrozole; Statins