title: Adjunctive use of systematic retinal thickness map analysis to monitor disease activity in punctate inner choroidopathy.
abstract: A challenge in the management of 'white dot syndromes' is the lack of sensitive objective measures of disease activity. Retinal thickness maps from spectral domain optical coherence tomography (SD-OCT) inform treatment decisions in other retinal conditions such as age-related macular degeneration and diabetic maculopathy. In this report, we demonstrate their value in providing quantitative monitoring of a patient with punctate inner choroidopathy (PIC). Retinal thickness maps referenced against a baseline scan reliably detected focal areas of increased macular volume in active PIC lesions during symptomatic episodes, highlighting these as 'hot spots' that could be quantified, providing an objective basis for treatment decisions.
authors.affiliation: Centre for Rare Diseases, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.|Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
authors.forename: Savitha
authors.initials: S
authors.lastname: Madhusudhan
authors.affiliation: NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
authors.forename: Pearse A
authors.initials: PA
authors.lastname: Keane
authors.affiliation: Centre for Rare Diseases, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. a.denniston@bham.ac.uk.|Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. a.denniston@bham.ac.uk.|Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. a.denniston@bham.ac.uk.
authors.forename: Alastair K
authors.identifier: http://orcid.org/0000-0001-7849-0087
authors.initials: AK
authors.lastname: Denniston
keywords: Macular grid; Punctate inner choroidopathy; Retinal thickness map; SD-OCT; White dot syndromes