title: High Expression of Cullin7 Correlates with Unfavorable Prognosis in Epithelial Ovarian Cancer Patients.
abstract: Ubiquitin ligase Cullin7 has been has been suggested to act as an oncogene in some tumors; however, the prognostic role of Cullin7 has not been evaluated in cancer patients. In this study, we observed that the expression of Cullin7 mRNA was significantly higher in epithelial ovarian cancer (EOC) compared with normal ovarian surface tissues. In addition, Cullin7 expression was related to FIGO stage (p = .001) and lymph node metastasis (p = .033). Furthermore, Cullin7 overexpression inhibited the migration and invasion of ovarian cancer cells. These results suggest that Cullin7 may serve as an indicator of poor prognosis in patients with EOC.
authors.affiliation: a Department of Gynecology , Cangzhou Central Hospital, Hebei Medical University , Cangzhou , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xi
authors.affiliation: a Department of Gynecology , Cangzhou Central Hospital, Hebei Medical University , Cangzhou , China.
authors.forename: Sai-Tian
authors.initials: ST
authors.lastname: Zeng
authors.affiliation: a Department of Gynecology , Cangzhou Central Hospital, Hebei Medical University , Cangzhou , China.
authors.forename: Liang
authors.initials: L
authors.lastname: Guo
authors.affiliation: a Department of Gynecology , Cangzhou Central Hospital, Hebei Medical University , Cangzhou , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D000077216:Carcinoma, Ovarian Epithelial; D045744:Cell Line, Tumor; D002465:Cell Movement; D044842:Cullin Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D055785:Gene Knockdown Techniques; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis / Q000201:enzymology* / Q000401:mortality; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000401:mortality; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D014408:Biomarkers, Tumor; C506299:CUL7 protein, human; D044842:Cullin Proteins