title: Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat.
abstract: Aging is the greatest risk factor for developing neurodegenerative diseases, which are associated with diminished neurotransmission as well as neuronal structure and function. However, several traits seemingly evolved to avert or delay age-related deterioration in the brain of the longest-lived rodent, the naked mole-rat (NMR). The NMR remarkably also exhibits negligible senescence, maintaining an extended healthspan for ~75 % of its life span. Using a proteomic approach, statistically significant changes with age in expression and/or phosphorylation levels of proteins associated with neurite outgrowth and neurotransmission were identified in the brain of the NMR and include: cofilin-1; collapsin response mediator protein 2; actin depolymerizing factor; spectrin alpha chain; septin-7; syntaxin-binding protein 1; synapsin-2 isoform IIB; and dynamin 1. We hypothesize that such changes may contribute to the extended lifespan and healthspan of the NMR.
authors.affiliation: Department of Chemistry, University of Kentucky, Lexington, KY, 40506-0055, USA.
authors.forename: Judy C
authors.initials: JC
authors.lastname: Triplett
authors.affiliation: Department of Chemistry, University of Kentucky, Lexington, KY, 40506-0055, USA.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Swomley
authors.affiliation: Department of Chemistry, University of Kentucky, Lexington, KY, 40506-0055, USA.
authors.forename: Jessime
authors.initials: J
authors.lastname: Kirk
authors.affiliation: Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, 78245, USA.|Department of Physiology, University of Texas Health Science Center, San Antonio, TX, 78245, USA.
authors.forename: Kelly M
authors.initials: KM
authors.lastname: Grimes
authors.affiliation: Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, 78245, USA.|Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, 78245, USA.
authors.forename: Kaitilyn N
authors.initials: KN
authors.lastname: Lewis
authors.affiliation: Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, 78245, USA.|Department of Physiology, University of Texas Health Science Center, San Antonio, TX, 78245, USA.
authors.forename: Miranda E
authors.initials: ME
authors.lastname: Orr
authors.affiliation: Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, 78245, USA.|Department of Physiology, University of Texas Health Science Center, San Antonio, TX, 78245, USA.
authors.forename: Karl A
authors.initials: KA
authors.lastname: Rodriguez
authors.affiliation: Department of Nephrology and Proteomics Center, University of Louisville, Louisville, KY, 40202, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Nephrology and Proteomics Center, University of Louisville, Louisville, KY, 40202, USA.
authors.forename: Jon B
authors.initials: JB
authors.lastname: Klein
authors.affiliation: Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, 78245, USA.|Department of Physiology, University of Texas Health Science Center, San Antonio, TX, 78245, USA.
authors.forename: Rochelle
authors.initials: R
authors.lastname: Buffenstein
authors.affiliation: Department of Chemistry, University of Kentucky, Lexington, KY, 40506-0055, USA. dabcns@uky.edu.|Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40506, USA. dabcns@uky.edu.
authors.forename: D Allan
authors.initials: DA
authors.lastname: Butterfield
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry / Q000502:physiology*; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D005260:Female; D008136:Longevity / Q000502:physiology; D008297:Male; D008565:Membrane Proteins / Q000032:analysis / Q000378:metabolism*; D019577:Mole Rats; D000071446:Neuronal Outgrowth / Q000502:physiology*; D040901:Proteomics / Q000379:methods*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D008565:Membrane Proteins
keywords: Aging; Naked mole-rat; Neurite outgrowth; Neurotransmission; Phosphoproteomics; Proteomics