title: Gammaherpesvirus targets peritoneal B-1 B cells for long-term latency.
abstract: Gammaherpesviruses establish life-long infection in most adults and are associated with the development of B cell lymphomas. While the interaction between gammaherpesviruses and splenic B cells has been explored, very little is known about gammaherpesvirus infection of B-1 B cells, innate-like B cells that primarily reside in body cavities. This study demonstrates that B-1 B cells harbor the highest frequency of latently infected cells in the peritoneum throughout chronic infection, highlighting a previously unappreciated feature of gammaherpesvirus biology.
authors.affiliation: Department of Microbiology and Molecular Genetics, United States.
authors.forename: Michaela M
authors.initials: MM
authors.lastname: Rekow
authors.affiliation: Department of Microbiology and Molecular Genetics, United States.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Darrah
authors.affiliation: Department of Microbiology and Molecular Genetics, United States.
authors.forename: Wadzanai P
authors.initials: WP
authors.lastname: Mboko
authors.affiliation: Department of Microbiology and Molecular Genetics, United States.
authors.forename: Philip T
authors.initials: PT
authors.lastname: Lange
authors.affiliation: Department of Microbiology and Molecular Genetics, United States; Cancer Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States. Electronic address: vera@mcw.edu.
authors.forename: Vera L
authors.initials: VL
authors.lastname: Tarakanova
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology / Q000821:virology*; D018142:Gammaherpesvirinae / Q000502:physiology*; D006566:Herpesviridae Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D054884:Host-Pathogen Interactions; D051379:Mice; D008810:Mice, Inbred C57BL; D022423:Myeloid Cells / Q000276:immunology / Q000473:pathology / Q000821:virology*; D010537:Peritoneum / Q000276:immunology / Q000473:pathology / Q000821:virology; D013154:Spleen / Q000276:immunology / Q000473:pathology / Q000821:virology*; D014775:Virus Activation; D017735:Virus Latency
keywords: B-1 B cells; Chronic infection; Gammaherpesvirus