title: Role of sulfatase 2 in lipoprotein metabolism and angiogenesis.
abstract: OBJECTIVE
  This article summarizes the current evidence to support a role of sulfatase 2 (SULF2) in triglyceride-rich lipoprotein (TRL) metabolism and angiogenesis.
  
  
  RESULTS
  Heparan sulfate proteoglycans (HSPG) are involved in the hepatic clearance of TRLs in mice and in humans. Different genetically modified mouse models have been instrumental to provide evidence that syndecan1, the core protein of HSPG, but also the degree of sulfation of the heparin sulfate chain, attached to syndecan 1, is important for hepatic TRL metabolism. Studies in humans demonstrate the regulating role of SULF2 in the hepatic uptake of TRL by HSPG and demonstrate the importance of 6-O-sulfation, modulated by SULF2, for HSPG function. The role of SULF2 in angiogenesis is illustrated by increased SULF2 mRNA expression in the stalk cells of angiogenic vascular sprouts that use fatty acids derived from TRL as a source for biomass production. Interestingly, SULF2 also interferes with HSPG-vascular endothelial growth factor binding, which impacts upon the angiogenic properties of stalk cells.
  
  
  CONCLUSIONS
  SULF2 is a multifaceted protein involved in TRL homeostasis and angiogenesis. Future investigations should focus on the potential benefits of targeting SULF2 in atherosclerosis and angiogenesis.
authors.affiliation: aDepartment of Ophthalmology bDepartment of Vascular cDepartment of Experimental Vascular Medicine, Academic Medical Center Amsterdam, University of Amsterdam, The Netherlands.
authors.forename: Marchien G
authors.initials: MG
authors.lastname: Dallinga
authors.forename: Geesje M
authors.initials: GM
authors.lastname: Dallinga-Thie
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000201:enzymology; D006497:Heparan Sulfate / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism*; D018919:Neovascularization, Physiologic; D013429:Sulfatases; D015238:Sulfotransferases / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
chemical_list: D006497:Heparan Sulfate; D008074:Lipoproteins; D013429:Sulfatases; D015238:Sulfotransferases; D042461:Vascular Endothelial Growth Factor A; C470792:SULF2 protein, human