title: Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum".
abstract: Physicians have traditionally viewed ischemic heart disease in a cardiocentric manner: plaques grow in arteries until they block blood flow, causing acute coronary and other ischemic syndromes. Recent research provides new insight into the integrative biology of inflammation as it contributes to ischemic cardiovascular disease. These results have revealed hitherto unsuspected inflammatory signaling networks at work in these disorders that link the brain, autonomic nervous system, bone marrow, and spleen to the atherosclerotic plaque and to the infarcting myocardium. A burgeoning clinical published data indicates that such inflammatory networks-far from a mere laboratory curiosity-operate in our patients and can influence aspects of ischemic cardiovascular disease that determine decisively clinical outcomes. These new findings enlarge the circle of the traditional "cardiovascular continuum" beyond the heart and vessels to include the nervous system, the spleen, and the bone marrow.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: plibby@rics.bwh.harvard.edu.
authors.forename: Peter
authors.initials: P
authors.lastname: Libby
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Matthias
authors.initials: M
authors.lastname: Nahrendorf
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Filip K
authors.initials: FK
authors.lastname: Swirski
mesh_terms: D006801:Humans; D007249:Inflammation / Q000473:pathology*; D007962:Leukocytes / Q000473:pathology*; D017202:Myocardial Ischemia / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*
keywords: acute coronary syndromes; myocardial infarction; white blood cells