title: Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications.
abstract: A new drug-delivery system of polymer nanoparticles (NPs) bearing pinacol-type boronic ester and alkyne moieties displaying triggered self-immolative polymer degradation in the presence of reactive oxygen species (ROS) with the capability of cellular imaging is presented. The NPs specifically release their drug cargo under concentrations of ROS that are commonly found in the intracellular environment of certain tumors and of inflamed tissues and exhibit significant cytotoxicity to cancer cells compared to their non-ROS-responsive counterparts.
authors.affiliation: Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. jager@imc.cas.cz hocherl@imc.cas.cz.
authors.forename: Eliézer
authors.initials: E
authors.lastname: Jäger
authors.affiliation: Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. jager@imc.cas.cz hocherl@imc.cas.cz.
authors.forename: Anita
authors.initials: A
authors.lastname: Höcherl
authors.affiliation: Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. jager@imc.cas.cz hocherl@imc.cas.cz.
authors.forename: Olga
authors.initials: O
authors.lastname: Janoušková
authors.affiliation: Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. jager@imc.cas.cz hocherl@imc.cas.cz.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Jäger
authors.affiliation: Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. jager@imc.cas.cz hocherl@imc.cas.cz.
authors.forename: Martin
authors.initials: M
authors.lastname: Hrubý
authors.affiliation: Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. jager@imc.cas.cz hocherl@imc.cas.cz.
authors.forename: Rafał
authors.initials: R
authors.lastname: Konefał
authors.affiliation: Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. jager@imc.cas.cz hocherl@imc.cas.cz.
authors.forename: Miloš
authors.initials: M
authors.lastname: Netopilik
authors.affiliation: Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. jager@imc.cas.cz hocherl@imc.cas.cz.
authors.forename: Jiří
authors.initials: J
authors.lastname: Pánek
authors.affiliation: Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. jager@imc.cas.cz hocherl@imc.cas.cz.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Šlouf
authors.affiliation: Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. jager@imc.cas.cz hocherl@imc.cas.cz.
authors.forename: Karel
authors.initials: K
authors.lastname: Ulbrich
authors.affiliation: Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. jager@imc.cas.cz hocherl@imc.cas.cz.
authors.forename: Petr
authors.initials: P
authors.lastname: Štěpánek
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002478:Cells, Cultured; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D008856:Microscopy, Fluorescence / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D010078:Oxazines / Q000737:chemistry / Q000493:pharmacokinetics; D011108:Polymers / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000494:pharmacology*
chemical_list: D001897:Boronic Acids; D004337:Drug Carriers; D005456:Fluorescent Dyes; D010078:Oxazines; D011108:Polymers; D017382:Reactive Oxygen Species; C044808:nile red