title: Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere.
abstract: Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of outbreaks accompanied by unexpectedly severe clinical complications brought this virus into the spotlight as causing an infection of global public health concern. In this review, we discuss the history and epidemiology of ZIKV infection, recent outbreaks in Oceania and the emergence of ZIKV in the Western Hemisphere, newly ascribed complications of ZIKV infection, including Guillain-Barré syndrome and microcephaly, potential interactions between ZIKV and dengue virus, and the prospects for the development of antiviral agents and vaccines.
authors.affiliation: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA helen.lazear@med.unc.edu diamond@borcim.wustl.edu.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Lazear
authors.affiliation: Departments of Medicine, Molecular Microbiology, Pathology, and Immunology and The Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, Missouri, USA helen.lazear@med.unc.edu diamond@borcim.wustl.edu.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Diamond
mesh_terms: D000330:Aedes / Q000821:virology; D000818:Animals; D003716:Dengue Virus / Q000276:immunology / Q000502:physiology; D004196:Disease Outbreaks; D004197:Disease Reservoirs / Q000821:virology; D005260:Female; D014943:Global Health; D020275:Guillain-Barre Syndrome / Q000209:etiology / Q000821:virology; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008831:Microcephaly / Q000821:virology; D000072138:Mosquito Vectors / Q000821:virology; D044349:Oceania / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D014765:Viral Vaccines; D000071244:Zika Virus / Q000235:genetics / Q000502:physiology*; D000071243:Zika Virus Infection / Q000150:complications / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*
chemical_list: D014765:Viral Vaccines