title: Tumor radio-sensitivity assessment by means of volume data and magnetic resonance indices measured on prostate tumor bearing rats.
abstract: OBJECTIVE
  Radiation therapy is one of the most common treatments in the fight against prostate cancer, since it is used to control the tumor (early stages), to slow its progression, and even to control pain (metastasis). Although many factors (e.g., tumor oxygenation) are known to influence treatment efficacy, radiotherapy doses and fractionation schedules are often prescribed according to the principle "one-fits-all," with little personalization. Therefore, the authors aim at predicting the outcome of radiation therapy a priori starting from morphologic and functional information to move a step forward in the treatment customization.
  
  
  METHODS
  The authors propose a two-step protocol to predict the effects of radiation therapy on individual basis. First, one macroscopic mathematical model of tumor evolution was trained on tumor volume progression, measured by caliper, of eighteen Dunning R3327-AT1 bearing rats. Nine rats inhaled 100% O2 during irradiation (oxy), while the others were allowed to breathe air. Second, a supervised learning of the weight and biases of two feedforward neural networks was performed to predict the radio-sensitivity (target) from the initial volume and oxygenation-related information (inputs) for each rat group (air and oxygen breathing). To this purpose, four MRI-based indices related to blood and tissue oxygenation were computed, namely, the variation of signal intensity ΔSI in interleaved blood oxygen level dependent and tissue oxygen level dependent (IBT) sequences as well as changes in longitudinal ΔR1 and transverse ΔR2(*) relaxation rates.
  
  
  RESULTS
  An inverse correlation of the radio-sensitivity parameter, assessed by the model, was found with respect the ΔR2(*) (-0.65) for the oxy group. A further subdivision according to positive and negative values of ΔR2(*) showed a larger average radio-sensitivity for the oxy rats with ΔR2(*)<0 and a significant difference in the two distributions (p < 0.05). Finally, a leave-one-out procedure yielded a radio-sensitivity error lower than 20% in both neural networks.
  
  
  CONCLUSIONS
  While preliminary, these specific results suggest that subjects affected by the same pathology can benefit differently from the same irradiation modalities and support the usefulness of IBT in discriminating between different responses.
authors.affiliation: Department of Electronics, Information and Bioengineering, Politecnico di Milano University, Milan 20133, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Belfatto
authors.affiliation: Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390.
authors.forename: Derek A
authors.initials: DA
authors.lastname: White
authors.affiliation: Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390.
authors.forename: Ralph P
authors.initials: RP
authors.lastname: Mason
authors.affiliation: Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390.
authors.forename: Strahinja
authors.initials: S
authors.lastname: Stojadinovic
authors.affiliation: Department of Electronics, Information and Bioengineering, Politecnico di Milano University, Milan 20133, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Baroni
authors.affiliation: Department of Electronics, Information and Bioengineering, Politecnico di Milano University, Milan 20133, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Cerveri
mesh_terms: D000818:Animals; D019583:Dose Fractionation, Radiation; D008279:Magnetic Resonance Imaging; D008297:Male; D008954:Models, Biological; D016571:Neural Networks, Computer; D010100:Oxygen / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy; D011836:Radiation Tolerance; D051381:Rats; D047368:Tumor Burden
chemical_list: D010100:Oxygen