title: Clear-Cell Atypical Fibroxanthoma: A Combined Immunohistochemistry Analysis.
abstract: Atypical fibroxanthoma is considered to be a low-grade sarcoma, characterized by a proliferation of bizarre spindled cells. A case of a rare variant of this tumor, a clear-cell atypical fibroxanthoma, presenting with rapid growth on a 63-year-old female, is reported. The differential diagnosis of a clear cell proliferation and a review of the immunohistochemistry markers used in the diagnosis of atypical fibroxanthoma are discussed. In particular, the usefulness of markers such as CD10, procollagen 1, CD68, CD163, CD99, and S100A6, and the importance of negative markers such as S100, cytokeratin, and desmin are emphasized. Furthermore, the development of a keratoacanthoma at the site of previous Mohs surgery is recounted.
authors.affiliation: Department of Dermatology, University of Puerto Rico, San Juan, Puerto Rico.
authors.forename: Cristina N
authors.initials: CN
authors.lastname: Brau Javier
authors.forename: Diana C
authors.initials: DC
authors.lastname: Valentín Colón
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Sánchez
authors.forename: Julio E
authors.initials: JE
authors.lastname: Sánchez
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D060787:Neoplasm Grading; D011237:Predictive Value of Tests; D012509:Sarcoma / Q000737:chemistry* / Q000473:pathology; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor