title: α-Carbamoylsulfides as N-Carbamoylimine Precursors in the Visible Light Photoredox-Catalyzed Synthesis of α,α-Disubstituted Amines.
abstract: A general and practical photoredox-promoted addition of nucleophiles to N-acylimines generated in situ from α-amidosulfides using Ru(bpy)3(PF6)2 as the photocatalyst is reported. The broad scope of the reaction toward various nucleophiles and amidosulfide derivatives was explored. This novel protocol provides a rapid, mild, and efficient access to valuable α,α-disubstituted amines in respectable yields.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay , 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Lebée
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay , 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Morgan
authors.initials: M
authors.lastname: Languet
authors.affiliation: PPSM, ENS Cachan, CNRS, Université Paris-Saclay , 94235 Cachan, France.
authors.forename: Clémence
authors.initials: C
authors.lastname: Allain
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay , 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Masson
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D008027:Light; D015394:Molecular Structure; D010084:Oxidation-Reduction; D055668:Photochemical Processes; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry*
chemical_list: D000588:Amines; D002219:Carbamates; D007097:Imines; D013440:Sulfides