title: Effect of nonsurgical periodontal treatment in patients with periodontitis and rheumatoid arthritis: A systematic review.
abstract: BACKGROUND
  Periodontitis has been regarded as a potential risk factor for rheumatoid arthrosis (RA). A systematic review is made to determine whether nonsurgical periodontal treatment in patients with RA offers benefits in terms of the clinical activity and inflammatory markers of the disease.
  
  
  METHODS
  A search was made of the Medline-PubMed, Cochrane, Embase and Scopus databases to identify studies on the relationship between the two disease processes, and especially on the effects of nonsurgical treatment in patients of this kind. The search was based on the following keywords: rheumatoid arthritis AND periodontitis (MeSH), rheumatoid arthritis AND periodontal treatment.
  
  
  RESULTS
  Eight articles on the nonsurgical treatment of patients with periodontitis and RA were finally included in the study. All of them evaluated clinical (DAS28) and laboratory test activity (ESR, CRP, IL-6, TNFα) before and after treatment. A clear decrease in DAS28 score and ESR was recorded, while other parameters such as CRP, IL-6 and TNFα showed a nonsignificant tendency to decrease as a result of treatment.
  
  
  CONCLUSIONS
  Nonsurgical treatment improved the periodontal condition of patients with periodontitis and RA, with beneficial effects upon the clinical and laboratory test parameters (DAS28 and ESR), while other inflammatory markers showed a marked tendency to decrease. However, all the studies included in the review involved small samples sizes and follow-up periods of no more than 6 months. Larger and particularly longitudinal studies are therefore needed to more firmly establish possible significant relations between the two disease processes.
authors.affiliation: Pacientes Especiales, Clínica Odontológica Universitaria, C/ Gascó Oliag 1, 46010-Valencia Spain, Francisco.silvestre@uv.es.
authors.forename: F-J
authors.initials: FJ
authors.lastname: Silvestre
authors.forename: J
authors.initials: J
authors.lastname: Silvestre-Rangil
authors.forename: L
authors.initials: L
authors.lastname: Bagán
authors.forename: J-V
authors.initials: JV
authors.lastname: Bagán
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000628:therapy; D002097:C-Reactive Protein; D006801:Humans; D015850:Interleukin-6; D010510:Periodontal Diseases; D010518:Periodontitis / Q000150:complications* / Q000628:therapy
chemical_list: D015850:Interleukin-6; D002097:C-Reactive Protein