title: In Vitro Anti-arthritic Activity.
abstract: Formaldehyde-induced arthritis and complete Freund's adjuvant (CFA)-induced arthritis in rats are well-known models to determine the anti-arthritic activity. Arthritis is a symptom of chronic inflammation. It is a chronic progressive disorder, developing over months or years and involving essentially the synovial joints of the body. Hence, these two models become the basis of this chapter to analyse the anti-arthritic activity.
mesh_terms: D000818:Animals; D018501:Antirheumatic Agents / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000097:blood / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D055808:Drug Discovery / Q000379:methods*; D004906:Erythrocyte Count; D005260:Female; D005557:Formaldehyde; D005620:Freund's Adjuvant; D006454:Hemoglobins / Q000378:metabolism; D018836:Inflammation Mediators / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D011489:Protein Denaturation / Q000187:drug effects*; D017208:Rats, Wistar
chemical_list: D018501:Antirheumatic Agents; D015415:Biomarkers; D006454:Hemoglobins; D018836:Inflammation Mediators; D005557:Formaldehyde; D005620:Freund's Adjuvant