title: Data publication with the structural biology data grid supports live analysis.
abstract: Access to experimental X-ray diffraction image data is fundamental for validation and reproduction of macromolecular models and indispensable for development of structural biology processing methods. Here, we established a diffraction data publication and dissemination system, Structural Biology Data Grid (SBDG; data.sbgrid.org), to preserve primary experimental data sets that support scientific publications. Data sets are accessible to researchers through a community driven data grid, which facilitates global data access. Our analysis of a pilot collection of crystallographic data sets demonstrates that the information archived by SBDG is sufficient to reprocess data to statistics that meet or exceed the quality of the original published structures. SBDG has extended its services to the entire community and is used to develop support for other types of biomedical data sets. It is anticipated that access to the experimental data sets will enhance the paradigm shift in the community towards a much more dynamic body of continuously improving data analysis.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115, USA.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Meyer
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Socias
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Key
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Ransey
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115, USA.
authors.forename: Emily C
authors.initials: EC
authors.lastname: Tjon
authors.affiliation: Laboratory of Molecular &Structural Microbiology, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.|Department of Structural Biology &Chemistry, Institut Pasteur, 75015 Paris, France.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Buschiazzo
authors.affiliation: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Lei
authors.affiliation: Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Botka
authors.affiliation: NE-CAT and Department of Chemistry and Chemical Biology, Cornell University, Building 436E, Argonne National Laboratory, 9700S. Cass Avenue, Argonne, Illinois 60439, USA.
authors.forename: James
authors.initials: J
authors.lastname: Withrow
authors.affiliation: NE-CAT and Department of Chemistry and Chemical Biology, Cornell University, Building 436E, Argonne National Laboratory, 9700S. Cass Avenue, Argonne, Illinois 60439, USA.
authors.forename: David
authors.initials: D
authors.lastname: Neau
authors.affiliation: NE-CAT and Department of Chemistry and Chemical Biology, Cornell University, Building 436E, Argonne National Laboratory, 9700S. Cass Avenue, Argonne, Illinois 60439, USA.
authors.forename: Kanagalaghatta
authors.initials: K
authors.lastname: Rajashankar
authors.affiliation: Departments of Pharmacology and Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
authors.forename: Karen S
authors.initials: KS
authors.lastname: Anderson
authors.affiliation: Department of Chemistry, Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.
authors.forename: Richard H
authors.initials: RH
authors.lastname: Baxter
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115, USA.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Blacklow
authors.affiliation: Departments of Pharmacology and Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
authors.forename: Titus J
authors.initials: TJ
authors.lastname: Boggon
authors.affiliation: Bijvoet Center, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands.
authors.forename: Alexandre M J J
authors.initials: AM
authors.lastname: Bonvin
authors.affiliation: Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Dominika
authors.initials: D
authors.lastname: Borek
authors.affiliation: Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.
authors.forename: Tom J
authors.initials: TJ
authors.lastname: Brett
authors.affiliation: Department of Biochemistry, University of Zurich, CH-8057 Zurich, Switzerland.
authors.forename: Amedeo
authors.initials: A
authors.lastname: Caflisch
authors.affiliation: Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
authors.forename: Chung-I
authors.initials: CI
authors.lastname: Chang
authors.affiliation: Departments of Biochemistry and Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, USA.
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Chazin
authors.affiliation: Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, California 92093, USA.|Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Corbett
authors.affiliation: Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, New York 13210, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Cosgrove
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Crosson
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
authors.forename: Sirano
authors.initials: S
authors.lastname: Dhe-Paganon
authors.affiliation: Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA.
authors.forename: Enrico
authors.initials: E
authors.lastname: Di Cera
authors.affiliation: Departments of Chemistry and Biology and the Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Drennan
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115, USA.|Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Eck
authors.affiliation: Department of Biological Sciences and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37235, USA.
authors.forename: Brandt F
authors.initials: BF
authors.lastname: Eichman
authors.affiliation: Departments of Pharmacology and Pathology and Cell Biology, Columbia University, New York, New York 10032, USA.
authors.forename: Qing R
authors.initials: QR
authors.lastname: Fan
authors.affiliation: Laboratory of RNA Biophysics, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892, USA.
authors.forename: Adrian R
authors.initials: AR
authors.lastname: Ferré-D'Amaré
authors.affiliation: Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, USA.
authors.forename: J Christopher
authors.initials: JC
authors.lastname: Fromme
authors.affiliation: Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA.|Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA.|Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
authors.forename: K Christopher
authors.initials: KC
authors.lastname: Garcia
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: Rachelle
authors.initials: R
authors.lastname: Gaudet
authors.affiliation: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Gong
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115, USA.|Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.|Laboratory of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Harrison
authors.affiliation: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
authors.forename: Ekaterina E
authors.initials: EE
authors.lastname: Heldwein
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada K7M 3G5.
authors.forename: Zongchao
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Keenan
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115, USA.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Kruse
authors.affiliation: Department of Biochemistry and Genetics, La Trobe University, Melbourne, Victoria 3086, Australia.
authors.forename: Marc
authors.initials: M
authors.lastname: Kvansakul
authors.affiliation: Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, USA.
authors.forename: Jason S
authors.initials: JS
authors.lastname: McLellan
authors.affiliation: Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
authors.forename: Yorgo
authors.initials: Y
authors.lastname: Modis
authors.affiliation: University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Yunsun
authors.initials: Y
authors.lastname: Nam
authors.affiliation: Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Zbyszek
authors.initials: Z
authors.lastname: Otwinowski
authors.affiliation: Departments of Biochemistry, Medical Biophysics and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.|Campbell Family Institute for Cancer Research, Ontario Cancer Institute/University Health Network, Toronto, Ontario, Canada M5G 2M9.
authors.forename: Emil F
authors.initials: EF
authors.lastname: Pai
authors.affiliation: IBMC-Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4150 Porto, Portugal.
authors.forename: Pedro José Barbosa
authors.initials: PJ
authors.lastname: Pereira
authors.affiliation: Université Grenoble Alpes/CNRS/CEA, Institut de Biologie Structurale, 38027 Grenoble, France.
authors.forename: Carlo
authors.initials: C
authors.lastname: Petosa
authors.affiliation: Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland 21201, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Raman
authors.affiliation: Howard Hughes Medical Institute and Harvard Medical School, Department of Cell Biology, Boston, Massachusetts 02115, USA.
authors.forename: Tom A
authors.initials: TA
authors.lastname: Rapoport
authors.affiliation: Cell Biology and Biophysics Unit, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA.|National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA.
authors.forename: Antonina
authors.initials: A
authors.lastname: Roll-Mecak
authors.affiliation: Department of Biophysics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Rosen
authors.affiliation: Department of Pharmacology and Toxicology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, USA.
authors.forename: Gabby
authors.initials: G
authors.lastname: Rudenko
authors.affiliation: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Schlessinger
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Thomas U
authors.initials: TU
authors.lastname: Schwartz
authors.affiliation: Department of BioSciences, Rice University, Houston, Texas 77005, USA.
authors.forename: Yousif
authors.initials: Y
authors.lastname: Shamoo
authors.affiliation: Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
authors.forename: Holger
authors.initials: H
authors.lastname: Sondermann
authors.affiliation: Department of BioSciences, Rice University, Houston, Texas 77005, USA.
authors.forename: Yizhi J
authors.initials: YJ
authors.lastname: Tao
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
authors.forename: Niraj H
authors.initials: NH
authors.lastname: Tolia
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Tsodikov
authors.affiliation: Departments of Biochemistry and Radiation Oncology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Westover
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115, USA.|Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, Illinois, and Department of Computer Science, University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Ian
authors.initials: I
authors.lastname: Foster
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California 94158, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Fraser
authors.affiliation: Laboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden.|NERSC, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
authors.forename: Filipe R N C
authors.initials: FR
authors.lastname: Maia
authors.affiliation: Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147 USA.
authors.forename: Tamir
authors.initials: T
authors.lastname: Gonen
authors.affiliation: Program in Cellular and Molecular Medicine and Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts 02115, USA.|Departments of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Tom
authors.initials: T
authors.lastname: Kirchhausen
authors.affiliation: Department of Biology, University of Konstanz, D-78457 Konstanz, Germany.
authors.forename: Kay
authors.initials: K
authors.lastname: Diederichs
authors.affiliation: Institute for Quantitative Social Science, Harvard University, Cambridge, Massachusetts, 02138, USA.
authors.forename: Mercè
authors.initials: M
authors.lastname: Crosas
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115, USA.
authors.forename: Piotr
authors.initials: P
authors.lastname: Sliz
mesh_terms: D018360:Crystallography, X-Ray; D030541:Databases, Genetic; D020407:Internet; D046911:Macromolecular Substances / Q000737:chemistry*; D011642:Publications; D012984:Software
chemical_list: D046911:Macromolecular Substances