title: Novel indexes of arrhythmogenesis in preeclampsia: QT dispersion, Tp-e interval, and Tp-e/QT ratio.
abstract: OBJECTIVE
  There is increasing evidence that preeclampsia (PE) may also be a risk factor for future cardiovascular diseases (CVDs), including arrhythmia. In this study we aimed to evaluate the association between PE and ventricular repolarization using novel electrocardiogram markers: QT interval duration, Tp-e interval, and Tp-e/QT ratio.
  
  
  METHODS
  In this controlled cross-sectional study sixty-four pregnant women with PE (31 with mild and 33 with severe disease) and 32 healthy women with uncomplicated pregnancies in the third trimester were compared by measuring QT parameters, Tp-e interval, and Tp-e/QT ratio.
  
  
  RESULTS
  Tp-e interval and Tp-e/QT ratio values were significantly higher in both the mild and severe PE groups compared to the healthy pregnant group.
  
  
  CONCLUSIONS
  Prevention of CVD requires that patients be aware of their risk factors, be educated about their risk, and perhaps most importantly perceive them to be at risk. In this study, we documented that PE has a significant effect on ventricular repolarization. This alteration could, in part, explain the increased cardiovascular risk in women with a history of PE. This important association can be used to screen women for increased risk in order to better target counseling regarding lifestyle modifications and to follow up and manage women with a history of hypertensive disease of pregnancy more closely.
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: drayse1982@yahoo.com.
authors.forename: Ayse
authors.initials: A
authors.lastname: Kirbas
authors.affiliation: Department of Cardiology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey. Electronic address: ozgurkirbas@yahoo.com.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Kirbas
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: drhkd1@gmail.com.
authors.forename: Korkut
authors.initials: K
authors.lastname: Daglar
authors.affiliation: Department of Obstetrics and Gynecology, Konya Education and Research Hospital, Konya, Turkey. Electronic address: dr.hasanaliinal@yahoo.com.
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Inal
authors.affiliation: Department of Cardiology, Mersin State Hospital, Mersin, Turkey. Electronic address: ozge_kurmus@yahoo.com.
authors.forename: Ozge
authors.initials: O
authors.lastname: Kurmus
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: drozgurkara@gmail.com.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Kara
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: drhakantimur@gmail.com.
authors.forename: Hakan
authors.initials: H
authors.lastname: Timur
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: drgulenay@yahoo.com.
authors.forename: Gulenay
authors.initials: G
authors.lastname: Gencosmanoglu
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: nuridanisman@gmail.com.
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
mesh_terms: D000200:Action Potentials; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Heart; Hypertension; SFlt-1; Ventricular arrhythmia