title: Effects of colchicine treatment on mean platelet volume and the inflammatory markers in recurrent aphthous stomatitis.
abstract: OBJECTIVE
  Recurrent aphthous stomatitis (RAS) is the most commonly seen inflammatory disease in the oral mucosa affecting 5%-25% of the general population. The etiology of RAS is still not fully understood and its treatment is very challenging. With its anti-inflammatory affects, colchicine is used for systematic treatment of RAS. In this study, we want to examine the effects of colchicine on platelet density, mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and red cell distribution width (RDW) of the patients with RAS.
  
  
  METHODS
  Fifteen male and 45 female RAS patients that were taking colchicine were investigated retrospectively. The whole blood parameters of the patients were observed before starting colchicine treatment and in the third month of colchicine treatment.
  
  
  RESULTS
  Significant decrease in the levels of NLR, white blood cell count and RDW of the RAS patients under colchicine treatment was observed. Moreover, no changes were seen on MPVs, PLRs and hemoglobin (Hb) levels.
  
  
  CONCLUSIONS
  It was determined that colchicine lowers the levels of NLR, white blood cell count and RDW. Furthermore, no changes were seen on MPVs, PLRs and Hb levels.
authors.affiliation: a Department of Dermatology , School of Medicine, Gaziosmanpasa University , Tokat , Turkey .
authors.forename: Havva Yıldız
authors.initials: HY
authors.lastname: Seçkin
authors.affiliation: b Department of Biochemistry , School of Medicine, Gaziosmanpasa University , Tokat , Turkey , and.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Bütün
authors.affiliation: a Department of Dermatology , School of Medicine, Gaziosmanpasa University , Tokat , Turkey .
authors.forename: Yalçın
authors.initials: Y
authors.lastname: Baş
authors.affiliation: a Department of Dermatology , School of Medicine, Gaziosmanpasa University , Tokat , Turkey .
authors.forename: Zennure
authors.initials: Z
authors.lastname: Takcı
authors.affiliation: c Department of Dermatology , School of Medicine, Yıldırım Beyazıt University , Ankara , Turkey.
authors.forename: Göknur
authors.initials: G
authors.lastname: Kalkan
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects; D003078:Colchicine / Q000627:therapeutic use*; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D063847:Mean Platelet Volume; D009504:Neutrophils / Q000187:drug effects; D012189:Retrospective Studies; D013281:Stomatitis, Aphthous / Q000097:blood / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D003078:Colchicine
keywords: Colchicine; mean platelet volume; neutrophil to lymphocyte ratio