title: Therapeutic Effect of Carboxyamidotriazole on Adjuvant Arthritis in Rats.
abstract: OBJECTIVE
  To study the effect of carboxyamidotriazole (CAI) on adjuvant arthritis (AA) in rats.
  
  
  METHODS
  The rats were randomly divided into normal group,two vehicle groups (polyethylene glycol 400 control and normal sodium control group), CAI-treated groups (10, 20, and 40 mg/kg) and positive control dexamethasone group. Freund's completed adjuvant was used to induce AA in rats. The arthritis index (AI) was scored, and X-ray check of the hind limbs and histopathological examination were performed. The levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in the inflamed paw tissues were measured.
  
  
  RESULTS
  The administration of CAI significantly decreased the AI, restored the body weights, and ameliorated the radiological and histopathological features of joint destruction in AA rats (P<0.05, P<0.01). In addition, CAI reduced the TNF-α, IL-1β, and IL-6 levels in the inflamed paw tissues (P<0.05, P<0.01).
  
  
  CONCLUSIONS
  CAI has therapeutic effect on AA rats, which may be achieved by decreasing the pro-inflammatory cytokines at the site of inflammation.
authors.affiliation: Department of Pharmacology,Institute of Basic Medical Sciences,CAMS and PUMC, Beijing 100005,China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Pharmacology,Institute of Basic Medical Sciences,CAMS and PUMC, Beijing 100005,China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pharmacology,Institute of Basic Medical Sciences,CAMS and PUMC, Beijing 100005,China.
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Pharmacology,Institute of Basic Medical Sciences,CAMS and PUMC, Beijing 100005,China.
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Yu
authors.affiliation: Department of Pharmacology,Institute of Basic Medical Sciences,CAMS and PUMC, Beijing 100005,China.
authors.forename: Dan-wei
authors.initials: DW
authors.lastname: Wu
authors.affiliation: Department of Pharmacology,Institute of Basic Medical Sciences,CAMS and PUMC, Beijing 100005,China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Pharmacology,Institute of Basic Medical Sciences,CAMS and PUMC, Beijing 100005,China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Pharmacology,Institute of Basic Medical Sciences,CAMS and PUMC, Beijing 100005,China.
authors.forename: Xiao-wan
authors.initials: XW
authors.lastname: Du
authors.affiliation: Department of Pharmacology,Institute of Basic Medical Sciences,CAMS and PUMC, Beijing 100005,China.
authors.forename: De-chang
authors.initials: DC
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology,Institute of Basic Medical Sciences,CAMS and PUMC, Beijing 100005,China.
authors.forename: Cai-ying
authors.initials: CY
authors.lastname: Ye
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental; D005620:Freund's Adjuvant; D053583:Interleukin-1beta; D015850:Interleukin-6; D051381:Rats; D014230:Triazoles; D014409:Tumor Necrosis Factor-alpha
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6; D014230:Triazoles; D014409:Tumor Necrosis Factor-alpha; C062058:carboxyamido-triazole; D005620:Freund's Adjuvant