title: A novel phospholipid delivery system of curcumin (Meriva®) preserves muscular mass in healthy aging subjects.
abstract: OBJECTIVE
  Curcumin is known to interrupt pro-inflammatory signalling and increases anti-oxidant protection, thus inhibiting the expression of inflammatory cytokines and the expression and function of inducible inflammatory enzymes. Together, these effects contribute to limit the onset and the progression of sarcopenia, due to the major role played by inflammation in the pathophysiology of this disease. This registry study evaluates the effects of Meriva® supplementation in otherwise healthy elderly subjects.
  
  
  METHODS
  This was a registry, supplement study, conducted in healthy subjects > 65 years with apparent loss of strength and tiredness who freely decided to start one of the following interventions: (1) standard management (exercise, balanced diet including proteins) (n = 33); (2) standard management + Meriva® one tablet/day (n = 31); (3) standard management + Meriva® one tablet/day + other supplementation (n = 22). A number of functional and biochemical parameters were evaluated at baseline and after three months (hand grip, weight lifting, time/distance before feeling tired after cycling, walking and climbing stairs; general fitness, proteinuria, oxidative stress, Karnofsky scale; left ventricular ejection fraction).
  
  
  RESULTS
  Significant improvements in all parameters, with respect to baseline values, were observed in the two supplementation groups (p < 0.05 for all comparisons). On the other hand, no improvement was observed in the standard management-only group. At three months, inter-group comparison revealed a statistical advantage in all parameters for both supplementation groups compared with the standard management-only group (p < 0.05 for all comparisons).
  
  
  CONCLUSIONS
  Our registry study shows that the addition of Meriva® - either or not combined with other nutritional supplements - to standardized diet and exercise plan contributes to improve strength and physical performance in elderly subjects, potentially preventing the onset of sarcopenia.
authors.affiliation: Indena S.p.A, Milan, Italy. Federico.franceschi@indena.com.
authors.forename: F
authors.initials: F
authors.lastname: Franceschi
authors.forename: B
authors.initials: B
authors.lastname: Feregalli
authors.forename: S
authors.initials: S
authors.lastname: Togni
authors.forename: U
authors.initials: U
authors.lastname: Cornelli
authors.forename: L
authors.initials: L
authors.lastname: Giacomelli
authors.forename: R
authors.initials: R
authors.lastname: Eggenhoffner
authors.forename: G
authors.initials: G
authors.lastname: Belcaro
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects* / Q000502:physiology; D003474:Curcumin / Q000008:administration & dosage*; D019587:Dietary Supplements; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D015444:Exercise / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000187:drug effects* / Q000502:physiology; D010743:Phospholipids / Q000008:administration & dosage*; D012042:Registries; D055948:Sarcopenia / Q000175:diagnosis / Q000517:prevention & control*
chemical_list: D010743:Phospholipids; D003474:Curcumin