title: Post-translational modifications in Pseudomonas aeruginosa revolutionized by proteomic analysis.
abstract: Pseudomonas aeruginosa is an opportunistic pathogen that causes severe infections in vulnerable individuals. It is known that post-translational modifications (PTMs) play a key role in bacterial physiology. Their characterization is still challenging and the recent advances in proteomics allow large-scale and high-throughput analyses of PTMs. Here, we provide an overview of proteomic data about the modified proteins in P. aeruginosa. We emphasize the significant contribution of proteomics in knowledge enhancement of PTMs (phosphorylation, N-acetylation and glycosylation) and we discuss their importance in P. aeruginosa physiology.
authors.affiliation: CNRS, UMR 6270, Polymères, Biopolymères, Surfaces Laboratory, F-76820 Mont-Saint-Aignan, France; Normandie Univ, UR, France; PISSARO Proteomic Facility, IRIB, F-76820 Mont-Saint-Aignan, France.
authors.forename: Tassadit
authors.initials: T
authors.lastname: Ouidir
authors.affiliation: CNRS, UMR 6270, Polymères, Biopolymères, Surfaces Laboratory, F-76820 Mont-Saint-Aignan, France; Normandie Univ, UR, France; PISSARO Proteomic Facility, IRIB, F-76820 Mont-Saint-Aignan, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Jouenne
authors.affiliation: CNRS, UMR 6270, Polymères, Biopolymères, Surfaces Laboratory, F-76820 Mont-Saint-Aignan, France; Normandie Univ, UR, France; PISSARO Proteomic Facility, IRIB, F-76820 Mont-Saint-Aignan, France. Electronic address: julie.hardouin@univ-rouen.fr.
authors.forename: Julie
authors.initials: J
authors.lastname: Hardouin
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D040901:Proteomics; D011550:Pseudomonas aeruginosa / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins
keywords: Acetylation; Glycosylation; Phosphorylation; Post-translational modifications; Proteomics; Pseudomonas aeruginosa