title: Pregnane glycosides from the antidepressant active fraction of cultivated Cynanchum otophyllum.
abstract: Based on the bioactive screening results, four new pregnane glycosides, namely cynanotophyllosides A-D (1-4) were isolated from the anti-depressant active fraction of cultivated Cynanchum otophyllum, along with thirteen known compounds (5-17). The new compounds were characterized as qingyangshengenin 3-O-β-D-glucopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside (1), qingyangshengenin-3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranoside (2), caudatin-3-O-β-D-glucopyranosyl-(1→4)-β-D-thevetopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranoside (3) caudatin-3-O-β-D-glucopyranosyl -(1→4)-β-D-thevetopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside (4), by detailed spectroscopic analysis and acidic hydrolysis.
authors.affiliation: School of Chemistry and Materials Science, Guizhou Normal University, Guiyang 550001, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Ethnic Medicine, Yunnan Minzu University, Kunming 650005, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Luo
authors.affiliation: School of Ethnic Medicine, Yunnan Minzu University, Kunming 650005, China.
authors.forename: Gan-Peng
authors.initials: GP
authors.lastname: Li
authors.affiliation: School of Chemistry and Materials Science, Guizhou Normal University, Guiyang 550001, China. Electronic address: yangqx@gznu.edu.cn.
authors.forename: Qing-Xiong
authors.initials: QX
authors.lastname: Yang
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry* / Q000302:isolation & purification; D031105:Cynanchum / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D008297:Male; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D064209:Phytochemicals / Q000737:chemistry* / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011278:Pregnanes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000928:Antidepressive Agents; D006027:Glycosides; D064209:Phytochemicals; D011278:Pregnanes; C574437:pregnane glycoside
keywords: Antidepressant; Cynanchum otophyllum; Cynanotophylloside; Pregnane glycosides