title: Anti-diabetic Activity.
abstract: The hyperglycaemia continues to be a major health problem in India and other developing countries. This imbalance of blood glucose causes serious health problems such as damages to the blood vessel, poor healing of wounds, retinal damage, renal damage--kidney failure. The in vitro enzyme models and evaluation of hypoglycaemic effect of sample on normal and glucose-loaded rats has been used as a prediction experiment in this chapter before going for anti-diabetic experiment using animal models.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D005260:Female; D005951:Glucose Tolerance Test; D065089:Glycoside Hydrolase Inhibitors / Q000494:pharmacology*; D006868:Hydrolysis; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D023421:Models, Animal; D009598:Nitrophenylgalactosides / Q000378:metabolism; D017208:Rats, Wistar; D013213:Starch / Q000378:metabolism; D013379:Substrate Specificity; D000516:alpha-Amylases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D009598:Nitrophenylgalactosides; C059200:4-nitrophenylgalactoside; D013213:Starch; D000516:alpha-Amylases; D000520:alpha-Glucosidases