title: Ocular toxicities of MEK inhibitors and other targeted therapies.
abstract: Many classes of anticancer therapy, including chemotherapeutic agents, hormonal and molecular targeted treatments, can produce ocular toxicity. Novel agents that target different cellular pathways have been related to a wide spectrum of ophthalmologic toxicities that can range from mild to severe, and include conjunctivitis, blurred vision, keratitis and optic neuritis, among others. Special attention has been drawn to the inhibitors of the MEK signaling pathway, due to their sine qua non ocular toxicity, defined as MEK retinopathy and described as symmetrical bilateral disease that develops in a time-dependent and dose-dependent manner. In this review, we discuss ophthalmologic toxicities associated with molecular targeted therapies, with particular focus on MEK retinopathy, including its nomenclature, incidence, symptoms and management.
authors.affiliation: Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-University Health Network, Toronto; Department of Medicine, University of Toronto, Toronto.
authors.forename: N
authors.initials: N
authors.lastname: Stjepanovic
authors.affiliation: Ocular Oncology Clinic, Princess Margaret Cancer Centre-University Health Network, Toronto, Canada. Electronic address: doctorjpvm@gmail.com.
authors.forename: J P
authors.initials: JP
authors.lastname: Velazquez-Martin
authors.affiliation: Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre-University Health Network, Toronto; Department of Medicine, University of Toronto, Toronto.
authors.forename: P L
authors.initials: PL
authors.lastname: Bedard
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D020930:MAP Kinase Kinase Kinases / Q000037:antagonists & inhibitors; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D012164:Retinal Diseases / Q000139:chemically induced / Q000145:classification / Q000453:epidemiology / Q000503:physiopathology*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D020930:MAP Kinase Kinase Kinases
keywords: MEK retinopathy; antineoplastic agents; mitogen-activated protein kinase; ocular toxicity; targeted therapies