title: Synthesis and photobactericidal properties of a neutral porphyrin grafted onto lignocellulosic fibers.
abstract: Photodynamic antimicrobial chemotherapy (PACT), as one of the promising alternative antimicrobial treatment, has received great attention in recent years. In this work, a new antimicrobial material has been elaborated by grafting a neutral porphyrin, the metallated 5-(4-azidophenyl)-10,15,20-triphenylporphyrin, onto lignocellulosic fibers by using the Copper (I)-Catalyzed Alkyne-Azide 1,3-dipolar Cycloaddition (CuAAC) reaction. The cross-linked porphyrin-Kraft pulp material was characterized by infrared and by XPS spectroscopy analyses, which proved the covalent linkage between the porphyrin and propargylated Kraft pulp fibers. The antimicrobial activity of this material was tested under visible light irradiation with a low light dose (9.5 J/cm(2)) against Staphylococcus aureus and Pseudomonas aeruginosa. The two bacterial strains deposited on the resulting photosensitizing Kraft pulp are efficiently killed after illumination. Such materials could find applications in industrial, household and medical environments as an alternative to overcome the widespread microbial multiresistance to classical treatments.
authors.affiliation: Laboratoire de chimie des substances naturelles, Université de Limoges, 123 avenue Albert Thomas, 87060 Limoges, France.
authors.forename: Jean Kerim
authors.initials: JK
authors.lastname: Nzambe Ta keki
authors.affiliation: Laboratoire de chimie des substances naturelles, Université de Limoges, 123 avenue Albert Thomas, 87060 Limoges, France.
authors.forename: Tan-Sothéa
authors.initials: TS
authors.lastname: Ouk
authors.affiliation: Laboratoire de chimie des substances naturelles, Université de Limoges, 123 avenue Albert Thomas, 87060 Limoges, France; Centre de Recherche sur les Matériaux Lignocellulosiques, Université du Québec à Trois-Rivières, 3351 boul. des Forges, C.P. 500, Trois-Rivières, QC G9A 5H7, Canada.
authors.forename: Rachida
authors.initials: R
authors.lastname: Zerrouki
authors.affiliation: Laboratoire de chimie des substances naturelles, Université de Limoges, 123 avenue Albert Thomas, 87060 Limoges, France.
authors.forename: Pierre-Antoine
authors.initials: PA
authors.lastname: Faugeras
authors.affiliation: Laboratoire de chimie des substances naturelles, Université de Limoges, 123 avenue Albert Thomas, 87060 Limoges, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Sol
authors.affiliation: Centre de Recherche sur les Matériaux Lignocellulosiques, Université du Québec à Trois-Rivières, 3351 boul. des Forges, C.P. 500, Trois-Rivières, QC G9A 5H7, Canada.
authors.forename: François
authors.initials: F
authors.lastname: Brouillette
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D061565:Cycloaddition Reaction; D008027:Light; D008031:Lignin / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D056951:Photoelectron Spectroscopy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000480:Alkynes; D000890:Anti-Infective Agents; D001386:Azides; D017319:Photosensitizing Agents; D011166:Porphyrins; C036909:lignocellulose; D003300:Copper; D008031:Lignin
keywords: Antimicrobials materials; Click-chemistry; Kraft pulp; Neutral porphyrin; Photodynamic antimicrobial chemotherapy