title: Glucagon-like peptide-1 does not have acute effects on central or renal hemodynamics in patients with type 2 diabetes without nephropathy.
abstract: During acute administration of native glucagon-like peptide-1 (GLP-1), we previously demonstrated central hemodynamic effects in healthy males, whereas renal hemodynamics, despite renal uptake of GLP-1 in excess of glomerular filtration, was unaffected. In the present study, we studied hemodynamic effects of GLP-1 in patients with type 2 diabetes under fixed sodium intake. During a 3-h infusion of GLP-1 (1.5 pmol·kg(-1)·min(-1)) or saline, intra-arterial blood pressure and heart rate were measured continuously, concomitantly with cardiac output estimated by pulse contour analysis. Renal plasma flow, glomerular filtration rate, and uptake/release of hormones and ions were measured using Fick's Principle after catheterization of a renal vein. Urine collection was conducted throughout the experiments at voluntary voiding, and patients remained supine during the experiments. During the GLP-1 infusion, systolic and diastolic blood pressure and cardiac output remained unchanged, whereas heart rate increased significantly. Arterio-venous gradients for GLP-1 exceeded glomerular filtrations significantly, but renal plasma flow and glomerular filtration rate as well as renal sodium and lithium excretion were not affected. In conclusion, acute administration of GLP-1 in patients with type 2 diabetes leads to a positive chronotropic effect, but in contrast to healthy individuals, cardiac output does not increase in patients with type 2 diabetes. Renal hemodynamics and sodium excretion are not affected.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Bispebjerg University Hospital, Copenhagen, Denmark; aliasmar@sund.ku.dk.
authors.forename: Ali
authors.initials: A
authors.lastname: Asmar
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Bispebjerg University Hospital, Copenhagen, Denmark;
authors.forename: Lene
authors.initials: L
authors.lastname: Simonsen
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Bispebjerg University Hospital, Copenhagen, Denmark;
authors.forename: Meena
authors.initials: M
authors.lastname: Asmar
authors.affiliation: Department of Endocrinology, Hvidovre University Hospital, Copenhagen, Denmark;
authors.forename: Sten
authors.initials: S
authors.lastname: Madsbad
authors.affiliation: Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark;
authors.forename: Jens J
authors.initials: JJ
authors.lastname: Holst
authors.affiliation: Department of Diagnostics, Clinical Physiology, and Nuclear Medicine, Glostrup University Hospital, Copenhagen, Denmark; and.
authors.forename: Erik
authors.initials: E
authors.lastname: Frandsen
authors.affiliation: Institut National de la Santé et de la Recherche Médicale UMR 1048, Institute of Metabolic and Cardiovascular Diseases, and Paul Sabatier University, Toulouse, France.
authors.forename: Cedric
authors.initials: C
authors.lastname: Moro
authors.affiliation: Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark;
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Sorensen
authors.affiliation: Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark;
authors.forename: Thomas
authors.initials: T
authors.lastname: Jonassen
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Bispebjerg University Hospital, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark;
authors.forename: Jens
authors.initials: J
authors.lastname: Bülow
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D052216:Glucagon-Like Peptide 1 / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects*; D017595:Renal Plasma Flow / Q000187:drug effects*; D012964:Sodium / Q000652:urine
chemical_list: D052216:Glucagon-Like Peptide 1; D012964:Sodium
keywords: blood pressure; cardiac output; glomerular filtration rate; glucagon-like peptide-1; heart rate; renal plasma flow; renal sodium excretion