title: Human T Follicular Helper Cells in Primary Immunodeficiency: Quality Just as Important as Quantity.
abstract: T follicular helper (Tfh) cells are a subset of effector CD4(+) T cells specialised to induce Ab production by B cells. This review highlights some of the recent advances in the field of human Tfh cells that have come from the study of primary immunodeficiencies. In particular it is increasingly evident that the quality of the Tfh cells that are generated, is just as important as the quantity.
authors.affiliation: Immunology Division, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW, 2010, Australia. c.ma@garvan.org.au.|St Vincent's Clinical School, University of New South Wales, Kensington, NSW, 2052, Australia. c.ma@garvan.org.au.
authors.forename: Cindy S
authors.identifier: 0000-0001-5387-8413
authors.initials: CS
authors.lastname: Ma
mesh_terms: D015415:Biomarkers; D016207:Cytokines / Q000378:metabolism; D004198:Disease Susceptibility; D005786:Gene Expression Regulation; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology* / Q000378:metabolism*; D010641:Phenotype; D018121:Receptors, Cytokine / Q000378:metabolism; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018121:Receptors, Cytokine; D014157:Transcription Factors
keywords: B-cell help; Human T follicular helper (Tfh) cells; humoral immunity; primary immunodeficiency