title: Mitochondrial Dynamics: ER Actin Tightens the Drp1 Noose.
abstract: Drp1 is an oligomeric GTPase essential for mitochondrial division. A recent study has proposed a new model whereby machinery localized to the endoplasmic reticulum drives polymerization of actin, which then acts as a platform for Drp1 oligomerization and hydrolysis at mitochondrial constriction sites.
authors.affiliation: Montreal Neurological Institute, McGill University, 3801 University Ave, Montreal, PQ H3A 2B4, Canada.
authors.forename: Julien
authors.initials: J
authors.lastname: Prudent
authors.affiliation: Montreal Neurological Institute, McGill University, 3801 University Ave, Montreal, PQ H3A 2B4, Canada. Electronic address: heidi.mcbride@mcgill.ca.
authors.forename: Heidi M
authors.initials: HM
authors.lastname: McBride
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008928:Mitochondria; D063154:Mitochondrial Dynamics; D024101:Mitochondrial Proteins / Q000378:metabolism
chemical_list: D000199:Actins; D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D020558:GTP Phosphohydrolases