title: Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic.
abstract: Malnutrition has been associated with increased morbidity and mortality. The objective of this study was to determine the nutritional status and micronutrient levels of hospitalized patients in an infectious disease clinic and investigate their association with adverse clinical outcomes. The nutritional status of the study participants was assessed using the Nutritional Risk Screening 2002 (NRS 2002) and micronutrient levels and routine biochemical parameters were tested within the first 24 h of the patient's admission. The incidence of zinc, selenium, thiamine, vitamin B6, vitamin B12 deficiency were 66.7% (n = 40), 46.6% (n = 29), 39.7% (n = 27), 35.3% (n = 24), 14.1% (n = 9), respectively. Selenium levels were significantly higher in patients with urinary tract infections, but lower in soft tissue infections. Copper levels were significantly higher in patients with soft tissue infections. In the Cox regression models, lower albumin, higher serum lactate dehydrogenase levels and higher NRS-2002 scores were associated with increased death. Thiamine, selenium, zinc and vitamin B6 deficiencies but not chromium deficiencies are common in infectious disease clinics. New associations were found between micronutrient levels and infection type and their adverse clinical outcomes. Hypoalbuminemia and a high NRS-2002 score had the greatest accuracy in predicting death, systemic inflammatory response syndrome and sepsis on admission.
authors.affiliation: Department of Internal Medicine and Clinical Nutrition, Kayseri Training and Research Hospital, 38010 Kayseri, Turkey. osdizdar@gmail.com.
authors.forename: Oguzhan Sıtkı
authors.initials: OS
authors.lastname: Dizdar
authors.affiliation: Department of Internal Medicine, Kayseri Training and Research Hospital, 38010 Kayseri, Turkey. osmanbaspinar1980@gmail.com.
authors.forename: Osman
authors.initials: O
authors.lastname: Baspınar
authors.affiliation: Department of Biochemistry, Kayseri Training and Research Hospital, 38010 Kayseri, Turkey. ayder78@yahoo.com.
authors.forename: Derya
authors.initials: D
authors.lastname: Kocer
authors.affiliation: Department of Clinic Microbiology and Infectious Disease, Kayseri Training and Research Hospital, 38010 Kayseri, Turkey. dr.zehrabestepe@hotmail.com.
authors.forename: Zehra Bestepe
authors.initials: ZB
authors.lastname: Dursun
authors.affiliation: Department of Internal Medicine, Kayseri Training and Research Hospital, 38010 Kayseri, Turkey. denav38@gmail.com.
authors.forename: Deniz
authors.initials: D
authors.lastname: Avcı
authors.affiliation: Department of Biochemistry, Kayseri Training and Research Hospital, 38010 Kayseri, Turkey. ckarakukcu@hotmail.com.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Karakükcü
authors.affiliation: Department of Clinic Microbiology and Infectious Disease, Kayseri Training and Research Hospital, 38010 Kayseri, Turkey. ilhamicelik@hotmail.com.
authors.forename: İlhami
authors.initials: İ
authors.lastname: Çelik
authors.affiliation: Division of Intensive care and Clinical Nutrition Unit, Erciyes University Medicine School, 38039 Kayseri, Turkey. kgundogan@erciyes.edu.tr.
authors.forename: Kursat
authors.initials: K
authors.lastname: Gundogan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001361:Avitaminosis / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003141:Communicable Diseases / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D044342:Malnutrition / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D008875:Middle Aged; D015596:Nutrition Assessment; D009752:Nutritional Status; D016017:Odds Ratio; D010343:Patient Admission; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D014815:Vitamins / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014815:Vitamins
keywords: death; infection; micronutrients; nutrition