title: DPPIV/CD26: a tumor suppressor or a marker of malignancy?
abstract: Dipeptidyl peptidase IV (DPPIV/CD26) is a multifunctional protein with intrinsic peptidase activity that inactivates or degrades some bioactive peptides. It is the main cellular binding protein for ecto-adenosine deaminase and interacts with extracellular matrix proteins, besides participating in different signaling pathways. Due to these multiple functions, DPPIV/CD26 has been shown to be closely related to the tumor process. It has been reported that the progression of certain types of cancer is accompanied by a decrease in DPPIV/CD26 expression, and studies have shown that the malignant phenotype can be reverted when DPPIV/CD26 expression is induced in these cancer cells, characterizing this protein as a tumor suppressor. On the other hand, DPPIV/CD26 was described as a protein associated with invasion and metastatic spread, characterizing it as a marker of malignancy. Thus, this review explores the roles of DPPIV/CD26 expression in tumor progression in different types of cancer and demonstrates the importance of this protein as a promising therapeutic target and tumor biomarker.
authors.affiliation: Programa de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.|Laboratório de Análises Bioquímicas e Citológicas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul-UFRGS, Av. Ipiranga 2752, Bairro Santana, Zip Code: 90610-000, Porto Alegre, RS, Brazil.
authors.forename: Aline
authors.initials: A
authors.lastname: Beckenkamp
authors.affiliation: Programa de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.|Laboratório de Análises Bioquímicas e Citológicas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul-UFRGS, Av. Ipiranga 2752, Bairro Santana, Zip Code: 90610-000, Porto Alegre, RS, Brazil.
authors.forename: Samuel
authors.initials: S
authors.lastname: Davies
authors.affiliation: Laboratório de Análises Bioquímicas e Citológicas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul-UFRGS, Av. Ipiranga 2752, Bairro Santana, Zip Code: 90610-000, Porto Alegre, RS, Brazil.
authors.forename: Júlia Biz
authors.initials: JB
authors.lastname: Willig
authors.affiliation: Programa de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. andreia.buffon@ufrgs.br.|Laboratório de Análises Bioquímicas e Citológicas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul-UFRGS, Av. Ipiranga 2752, Bairro Santana, Zip Code: 90610-000, Porto Alegre, RS, Brazil. andreia.buffon@ufrgs.br.
authors.forename: Andréia
authors.initials: A
authors.lastname: Buffon
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D016147:Genes, Tumor Suppressor; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4
keywords: Biomarker; CD26; DPPIV; Marker of malignancy; Therapeutic target; Tumor suppressor