title: Conformational Study of N,N'-Diacyl Bispidines and Dioxo Bis-bispidines: Planar Chirality and Molecular Switching.
abstract: N,N'-Diacyl bispidines exhibit chirality in the absence of a chiral center and axis. Conformational analysis indicates planar chirality in the molecular structure as a result of open-ended chiral planes, which has been confirmed by X-ray diffraction studies. Substantial chiral-achiral molecular switching is observed in di(haloacetyl) bispidines upon changing the solvent polarity. Tethering the chiral planes with a bispidine linker alters the planar chirality significantly and renders the resulting bis-bispidine macrocycles achiral.
authors.affiliation: Department of Chemistry and Biochemistry, University of Windsor , 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Biochemistry, University of Windsor , 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada.
authors.forename: Md Jahirul
authors.initials: MJ
authors.lastname: Islam
authors.affiliation: Department of Chemistry and Biochemistry, University of Windsor , 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada.
authors.forename: V Nicholas
authors.initials: VN
authors.lastname: Vukotic
authors.affiliation: Department of Chemistry and Biochemistry, University of Windsor , 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Revington