title: Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice.
abstract: Despite its therapeutic advantages, chemotherapy can also cause adverse effects, including anorexia and loss of appetite. Although numerous patients with cancer have been reported to suffer from anorexia during or following chemotherapy, treatment options for anorexia remain to be determined. In Asian countries, traditional medicines are widely used to treat problems with appetite; sip-jeon-dea-bo-tang (SJDBT) is one of those medicines used for the treatment of anorexia. The present study demonstrated that SJDBT ameliorated cisplatin-induced anorexia. In a mouse model of chemotherapy-induced anorexia, oral administration of SJDBT prevented the cisplatin-induced reduction of food intake, inhibiting weight loss. The results of multiplex assays showed that SJDBT only altered the levels of interleukin (IL)-6 and leptin in the serum and fat tissue. In addition, SJDBT maintained the serum leptin level and increased the serum IL-6 level, whereas cisplatin reduced the levels of both serum leptin and IL‑6. Furthermore, SJDBT was revealed to increase the levels of leptin and IL-6 in the fat tissue by activating the JAK1/STAT3 signaling pathway. In conclusion, the present results revealed that SJDBT ameliorated cisplatin-induced anorexia, suggesting its usefulness in the prevention of anorexia during chemotherapy.
authors.affiliation: Department of Preventive Medicine, College of Republic of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea.
authors.forename: Sang-Mi
authors.initials: SM
authors.lastname: Woo
authors.affiliation: Department of Preventive Medicine, College of Republic of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea.
authors.forename: Youn Kyung
authors.initials: YK
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, College of Republic of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea.
authors.forename: Ah-Jeong
authors.initials: AJ
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, College of Republic of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea.
authors.forename: Yee Jin
authors.initials: YJ
authors.lastname: Yun
authors.affiliation: Department of Preventive Medicine, College of Republic of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea.
authors.forename: Yong Cheol
authors.initials: YC
authors.lastname: Shin
authors.affiliation: Department of Preventive Medicine, College of Republic of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea.
authors.forename: Sung-Gook
authors.initials: SG
authors.lastname: Cho
authors.affiliation: Department of Preventive Medicine, College of Republic of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea.
authors.forename: Seong Gyu
authors.initials: SG
authors.lastname: Ko
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D000855:Anorexia / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000009:adverse effects; D002945:Cisplatin / Q000009:adverse effects; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015850:Interleukin-6 / Q000096:biosynthesis*; D053613:Janus Kinase 1 / Q000378:metabolism*; D020738:Leptin / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D020738:Leptin; D050796:STAT3 Transcription Factor; D053613:Janus Kinase 1; D002945:Cisplatin