title: PET Imaging of Tau Deposition in the Aging Human Brain.
abstract: Tau pathology is a hallmark of Alzheimer's disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent (18)F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. The present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition.
authors.affiliation: Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, 94720, USA.|MedTech West and the Department of Clinical Neuroscience and Rehabilitation, University of Gothenburg, 405 30 Gothenburg, Sweden.
authors.forename: Michael
authors.initials: M
authors.lastname: Schöll
authors.affiliation: Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, 94720, USA.
authors.forename: Samuel N
authors.initials: SN
authors.lastname: Lockhart
authors.affiliation: Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, 94158, USA.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Schonhaut
authors.affiliation: Lawrence Berkeley National Laboratory, Berkeley, California, 94720, USA.
authors.forename: James P
authors.initials: JP
authors.lastname: O'Neil
authors.affiliation: Lawrence Berkeley National Laboratory, Berkeley, California, 94720, USA.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Janabi
authors.affiliation: Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, 94720, USA.|Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, 94158, USA.|Department of Neurology & Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, 1081 HV Amsterdam, The Netherlands.
authors.forename: Rik
authors.initials: R
authors.lastname: Ossenkoppele
authors.affiliation: Lawrence Berkeley National Laboratory, Berkeley, California, 94720, USA.
authors.forename: Suzanne L
authors.initials: SL
authors.lastname: Baker
authors.affiliation: Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, 94720, USA.
authors.forename: Jacob W
authors.initials: JW
authors.lastname: Vogel
authors.affiliation: Lawrence Berkeley National Laboratory, Berkeley, California, 94720, USA.
authors.forename: Jamie
authors.initials: J
authors.lastname: Faria
authors.affiliation: Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, 94720, USA.
authors.forename: Henry D
authors.initials: HD
authors.lastname: Schwimmer
authors.affiliation: Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, 94720, USA.|Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, 94158, USA.|Lawrence Berkeley National Laboratory, Berkeley, California, 94720, USA.
authors.forename: Gil D
authors.initials: GD
authors.lastname: Rabinovici
authors.affiliation: Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, 94720, USA.|Lawrence Berkeley National Laboratory, Berkeley, California, 94720, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Jagust
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000544:Alzheimer Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D000814:Aniline Compounds / Q000493:pharmacokinetics; D001057:Apolipoproteins E / Q000235:genetics; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D003072:Cognition Disorders / Q000209:etiology; D005026:Ethylene Glycols / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D011569:Psychiatric Status Rating Scales; D013844:Thiazoles / Q000493:pharmacokinetics; D055815:Young Adult; D016875:tau Proteins / Q000378:metabolism*
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D001057:Apolipoproteins E; D005026:Ethylene Glycols; D013844:Thiazoles; D016875:tau Proteins; C545186:florbetapir
keywords: PET; aging; amyloid; memory; tau