title: Fecal Microbiota Transplantation Inhibits Multidrug-Resistant Gut Pathogens: Preliminary Report Performed in an Immunocompromised Host.
abstract: Colonization of the gastrointestinal tract with multidrug-resistant (MDR) bacteria is a consequence of gut dysbiosis. We describe the successful utilization of fecal microbiota transplantation to inhibit Klebsiella pneumoniae MBL(+) and Escherichia coli ESBL(+) gut colonization in the immunocompromised host as a novel tool in the battle against MDR microorganisms. ClinicalTrials.gov identifier NCT02461199.
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Banacha 1A, 02-097, Warsaw, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Biliński
authors.affiliation: Foundation for the Infection Prevention Institute, Warsaw, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Grzesiowski
authors.affiliation: Department of Gastroenterology and Metabolic Diseases, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Muszyński
authors.affiliation: Department of Microbiology, Central Clinical Hospital, Medical University of Warsaw, Warsaw, Poland.|Department of Dental Microbiology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Wróblewska
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Banacha 1A, 02-097, Warsaw, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Mądry
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Banacha 1A, 02-097, Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Robak
authors.affiliation: Department of Microbiology, Central Clinical Hospital, Medical University of Warsaw, Warsaw, Poland.|Department of Medical Microbiology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Dzieciątkowski
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Banacha 1A, 02-097, Warsaw, Poland.
authors.forename: Wiesław
authors.initials: W
authors.lastname: Wiktor-Jedrzejczak
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Banacha 1A, 02-097, Warsaw, Poland. grzegorz.basak@wum.edu.pl.
authors.forename: Grzegorz W
authors.initials: GW
authors.lastname: Basak
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D064806:Dysbiosis / Q000628:therapy; D004926:Escherichia coli; D000069467:Fecal Microbiota Transplantation / Q000379:methods*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007413:Intestinal Mucosa / Q000382:microbiology*; D007711:Klebsiella pneumoniae; D008297:Male; D064307:Microbiota; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy; D010641:Phenotype; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents
keywords: Antibiotic-resistant bacteria; Fecal microbiota transplantation; Gut colonization