title: All that glitters is not gold: the need to consider desirable and undesirable immune aspects of oncolytic virus therapy.
abstract: Oncolytic viruses (OVs), a novel class of anticancer therapeutic agents, can overturn cancer-mediated immunosuppression and initiate antitumor immunity. Contrary to this paradigm, our recent study illustrates that oncolytic reovirus transiently augments cancer-associated immunosuppression immediately following its therapeutic administration. To achieve the optimum efficacy for OV-based anticancer therapies, the pathophysiological as well as clinical implications of this phenomenon need to be considered.
authors.affiliation: Department of Pathology; Dalhousie University ; Halifax, NS Canada.
authors.forename: Derek R
authors.initials: DR
authors.lastname: Clements
authors.affiliation: Department of Pathology; Dalhousie University ; Halifax, NS Canada.
authors.forename: Youra
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Microbiology and Immunology; Dalhousie University; Halifax, NS Canada; Strategy & Organizational Performance; IWK Health Centre; Halifax, NS Canada.
authors.forename: Shashi A
authors.initials: SA
authors.lastname: Gujar
authors.affiliation: Department of Pathology; Dalhousie University; Halifax, NS Canada; Department of Microbiology and Immunology; Dalhousie University; Halifax, NS Canada.
authors.forename: Patrick Wk
authors.initials: PW
authors.lastname: Lee
keywords: MDSCs; antitumor immunity; immunosuppression; oncolytic virus; reovirus; tumor microenvironment