title: Predicting Peak Oxygen Uptake From the 6-Minute Walk Test in Patients With Pulmonary Hypertension.
abstract: OBJECTIVE
  To determine whether the 6-minute walk test (6MWT) is a predictor of peak oxygen uptake ((Equation is included in full-text article.)O2) in patients with idiopathic pulmonary arterial hypertension (IPAH).
  
  
  METHODS
  A total of 157 patients treated for IPAH completed a 6MWT in accordance with American Thoracic Society standards. Heart rate, pulse oximetry, and Borg rating of perceived exertion were determined at baseline and posttest. A cardiopulmonary exercise test (CPET) was performed on a cycle ergometer using a ramp protocol. Participants were stratified post hoc by age into 3 groups: children (n = 26), adolescents (n = 49), and adults (n = 82). Multiple linear regression analysis was performed to predict peak (Equation is included in full-text article.)O2 from the 6MWT.
  
  
  RESULTS
  The regression equation generated for the children was the only model to strongly predict peak (Equation is included in full-text article.)O2 (r = 0.87; P < .001). Similar models for adolescent (r = 0.59; P < .001) and adult groups (r = 0.68; P < .001) did not achieve the same level of correlation.
  
  
  CONCLUSIONS
  Six-Minute Walk Test was able to accurately predict peak (Equation is included in full-text article.)O2 in children (6-12 years) with IPAH; however, the model was weaker for predicting peak (Equation is included in full-text article.)O2 in older populations. These findings suggest that 6MWT may be as valid a test for predicting peak (Equation is included in full-text article.)O2 in children with IPAH as CPET measured peak (Equation is included in full-text article.)O2. In older IPAH populations, CPET is the only reliable method for the evaluation of peak (Equation is included in full-text article.)O2.
authors.affiliation: Technical University of Madrid, Madrid, Spain (Drs Zapico and Calderón and Messrs Fuentes and Rojo-Tirado); Complutense University of Madrid, Madrid, Spain (Dr Zapico); and New York Presbyterian Hospital/Columbia University Medical Center, New York (Mr Fuentes and Drs Rosenzweig and Garofano).
authors.forename: Augusto G
authors.initials: AG
authors.lastname: Zapico
authors.forename: Darío
authors.initials: D
authors.lastname: Fuentes
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Rojo-Tirado
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Calderón
authors.forename: Erika B
authors.initials: EB
authors.lastname: Rosenzweig
authors.forename: Robert P
authors.initials: RP
authors.lastname: Garofano
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D065627:Familial Primary Pulmonary Hypertension / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate; D006801:Humans; D016014:Linear Models; D008297:Male; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D005082:Physical Exertion; D011237:Predictive Value of Tests; D012044:Regression Analysis; D014797:Vital Capacity; D000070857:Walk Test; D055815:Young Adult
chemical_list: D010100:Oxygen