title: Association between depression, parameters of adiposity and genetic polymorphisms of pro-inflammatory cytokines: IL-1α, IL-1β, IL-2 and IL-6 in subjects over 55 years old.
abstract: During the last few decades, adiposity has become a relatively common phenomenon worldwide. The available data on the effects of pro-inflammatory factors in both depression and adiposity has been attracting great attention.
  
  
  
  We sought to assess the prevalence of -889C>T IL-1α, -31T>C and -511C>T IL-1β, -330T>G IL-2 and -174G>C IL-6 genes and their association with adiposity and depression in Polish subjects.
  
  
  
  A cohort study was conducted in 2013/2014, covering a sample of 297 individuals (217 female and 80 male). Anthropometric data was handled using the BIA analysis method, while for genotyping PCR-RFLP techniques were used.
  
  
  
  A positive correlation between depression and anthropometric parameters: adipose tissue (in kg) and adipose tissue (in %) (R=0.135 and p=0.02, R=0.114 and p<0.05, respectively) was found. No association between studied polymorphisms and depression was observed.
  
  
  
  Although it was not possible to demonstrate any influence of the studied polymorphisms as the genetic modulator of depression, authors believe that the presented data are noticeable and may provide the basis for future studies on larger groups.
authors.affiliation: Department of Gerontobiology, Pomeranian Medical University, Szczecin, Szczecin, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Adler
authors.affiliation: Department of Gerontobiology, Pomeranian Medical University, Szczecin, Szczecin, Poland.
authors.forename: Karolina
authors.initials: K
authors.lastname: Skonieczna-Żydecka
authors.affiliation: Department of Gerontobiology, Pomeranian Medical University, Szczecin, Szczecin, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Madlani
authors.affiliation: Department of Civilization Diseases, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Ogonowski
authors.affiliation: Department of Nursing, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Grochans
authors.affiliation: Department of Public Health, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Pierzak-Sominka
authors.affiliation: Laboratory of Primary Health Care, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Brodowski
authors.affiliation: Chair and Department of Public Health, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Karakiewicz
mesh_terms: D050154:Adiposity / Q000235:genetics; D000368:Aged; D003863:Depression / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D007376:Interleukin-2 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: C508584:IL1A protein, human; C508585:IL1B protein, human; C508594:IL2 protein, human; C508600:IL6 protein, human; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D007376:Interleukin-2; D015850:Interleukin-6