title: Dependence of ultrasound echo decorrelation on local tissue temperature during ex vivo radiofrequency ablation.
abstract: This study investigates echo decorrelation imaging, an ultrasound method for thermal ablation monitoring. The effect of tissue temperature on the mapped echo decorrelation parameter was assessed in radiofrequency ablation experiments performed on ex vivo bovine liver tissue. Echo decorrelation maps were compared with corresponding tissue temperatures simulated using the finite element method. For both echo decorrelation imaging and integrated backscatter imaging, the mapped tissue parameters correlated significantly but weakly with local tissue temperature. Receiver operating characteristic (ROC) curves were used to assess the ability of echo decorrelation and integrated backscatter to predict tissue temperature greater than 40, 60, and 80 °C. Significantly higher area under the ROC curve (AUROC) values were obtained for prediction of tissue temperatures greater than 40, 60, and 80 °C using echo decorrelation imaging (AUROC = 0.871, 0.948 and 0.966) compared to integrated backscatter imaging (AUROC = 0.865, 0.877 and 0.832).
authors.affiliation: Department of Biomedical, Chemical, and Environmental Engineering, University of Cincinnati, Cincinnati, OH, USA.
authors.forename: Swetha
authors.initials: S
authors.lastname: Subramanian
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Schmidt
authors.forename: Marepalli B
authors.initials: MB
authors.lastname: Rao
authors.forename: T Douglas
authors.initials: TD
authors.lastname: Mast
mesh_terms: D000818:Animals; D001831:Body Temperature; D002417:Cattle; D019220:High-Energy Shock Waves / Q000627:therapeutic use; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D008099:Liver / Q000000981:diagnostic imaging* / Q000601:surgery; D012680:Sensitivity and Specificity