title: A Case of Kounis Type I in a Young Woman With Samter's Triad.
abstract: Kounis syndrome is defined as an acute coronary syndrome triggered by allergic or hypersensitivity reactions resulting in mast cell and platelet activation. Numerous causes have been described, including various drugs, medical conditions, and environmental exposures. Samter's triad consists of nasal polyps, asthma, and aspirin (or nonsteroidal anti-inflammatory drug) sensitivity. We describe a case of Kounis type I in a young woman with Samter's triad who presented with cardiac arrest on 3 occasions. Ergonovine provocation testing established the diagnosis of coronary vasospasm. The patient has derived significant benefit from calcium channel blockers.
authors.affiliation: Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Erin
authors.initials: E
authors.lastname: Rayner-Hartley
authors.affiliation: Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Annie
authors.initials: A
authors.lastname: Chou
authors.affiliation: Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Saw
authors.affiliation: Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: tara.sedlak@vch.ca.
authors.forename: Tara
authors.initials: T
authors.lastname: Sedlak
mesh_terms: D054058:Acute Coronary Syndrome / Q000209:etiology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001241:Aspirin / Q000009:adverse effects; D055963:Asthma, Aspirin-Induced; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis*; D004342:Drug Hypersensitivity; D004874:Ergonovine; D005260:Female; D006323:Heart Arrest / Q000209:etiology; D006801:Humans; D009298:Nasal Polyps; D014336:Troponin / Q000097:blood; D014665:Vasodilator Agents; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014336:Troponin; D014665:Vasodilator Agents; D001241:Aspirin; D004874:Ergonovine