title: Influence of initial insulin dosage on blood glucose dynamics of children and adolescents with newly diagnosed type 1 diabetes mellitus.
abstract: To investigate the effect of initial insulin dosage on blood glucose (BG) dynamics, β-cell protection, and oxidative stress in type 1 diabetes mellitus.
  
  
  
  Sixty newly diagnosed type 1 diabetes mellitus patients were randomly assigned to continuous subcutaneous insulin infusions of 0.6 ± 0.2 IU/kg/d (group 1), 1.0 ± 0.2 IU/kg/d (group 2), or 1.4 ± 0.2 IU/kg/d (group 3) for 3 wk. BG was monitored continuously for the first 10 d and the last 2 d of wk 2 and 3. A total of 24-hour urinary 8-iso-PGF2α was assayed on days 8, 9, and 10. The occurrence and duration of the honeymoon period were recorded. Fasting C-peptide and glycosylated hemoglobin (HbA1c) were assayed after 1, 6, and 12 months of insulin treatment.
  
  
  
  BG decreased to the target range by the end of wk 3 (group 1), wk 2 (group 2), or wk 1 (group 3). The actual insulin dosage over the 3 wk, frequency of hypoglycemia on wk 1 and 2, and median BG at the end of wk 1 differed significantly, but not 8-iso-PGF2α and the honeymoon period in the three groups. No severe hypoglycemia event was observed in any patient, but there was significant difference in the first occurrence of hypoglycemia.
  
  
  
  Differences in initial insulin dosage produced different BG dynamics in wk 1, equivalent BG dynamics on wk 2 and 3, but had no influence on short- and long-term BG control and honeymoon phase. The wide range of initial insulin dosage could be chosen if guided by BG monitoring.
authors.affiliation: Department of Endocrinology, Genetics and Metabolism, The Capital Medical University, Beijing Children's Hospital, Beijing, 100045, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Genetics and Metabolism, The Capital Medical University, Beijing Children's Hospital, Beijing, 100045, PR China.
authors.forename: Chunxiu
authors.initials: C
authors.lastname: Gong
authors.affiliation: Department of Endocrinology, Genetics and Metabolism, The Capital Medical University, Beijing Children's Hospital, Beijing, 100045, PR China.
authors.forename: Bingyan
authors.initials: B
authors.lastname: Cao
authors.affiliation: Department of Endocrinology, Genetics and Metabolism, The Capital Medical University, Beijing Children's Hospital, Beijing, 100045, PR China.
authors.forename: Xi
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Endocrinology, Genetics and Metabolism, The Capital Medical University, Beijing Children's Hospital, Beijing, 100045, PR China.
authors.forename: Liya
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Endocrinology, Genetics and Metabolism, The Capital Medical University, Beijing Children's Hospital, Beijing, 100045, PR China.
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Endocrinology, Genetics and Metabolism, The Capital Medical University, Beijing Children's Hospital, Beijing, 100045, PR China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Endocrinology, Genetics and Metabolism, The Capital Medical University, Beijing Children's Hospital, Beijing, 100045, PR China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Genetics and Metabolism, The Capital Medical University, Beijing Children's Hospital, Beijing, 100045, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Genetics and Metabolism, The Capital Medical University, Beijing Children's Hospital, Beijing, 100045, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Department of Endocrinology, Genetics and Metabolism, The Capital Medical University, Beijing Children's Hospital, Beijing, 100045, PR China.
authors.forename: Chang
authors.initials: C
authors.lastname: Su
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000652:urine; D001786:Blood Glucose / Q000032:analysis*; D002096:C-Peptide / Q000097:blood; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control*; D007003:Hypoglycemia / Q000139:chemically induced / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D007332:Insulin Infusion Systems; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018670:Monitoring, Ambulatory; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002096:C-Peptide; D015237:Dinoprost; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; C517652:hemoglobin A1c protein, human; C075750:8-epi-prostaglandin F2alpha
keywords: adolescents; blood glucose; children; insulin dosage; type 1 diabetes mellitus