title: Effect of Transsphenoidal Adenectomy on Glucose Tolerance Status in Patients with Growth Hormone-secreting Pituitary Adenoma.
abstract: OBJECTIVE
  To explore the effect of transsphenoidal adenectomy on glucose tolerance status in patients with growth hormone (GH)-secreting pituitary adenoma.
  
  
  METHODS
  The clinical data of 105 patients with GH-secreting pituitary adenoma who underwent transsphenoidal adenectomy in our department in 2013 were retrospectively analyzed. The glucose tolerance status, GH level, and insulin-like growth factor-1 (IGF-1) level before and after surgery were compared.
  
  
  RESULTS
  Among these 105 patients, the blood glucose tolerance status included normal glucose tolerance (NGT) in 47 cases (44.8%), early carbohydrate metabolism disorders (ECMDs) in 26 cases (24.8%), and diabetes mellitus (DM) in 32 cases (30.5%) before surgery. After the surgery, the fasting blood glucose (P=0.006, P=0.017) and postprandial blood glucose (P=0.000, P=0.000) in the ECMDs and DM groups were significantly improved. Also, the random GH (P=0.001, P=0.004, P=0.001), nadir GH (P=0.000, P=0.001, P=0.001), and IGF-1 (P=0.005, P=0.000, P=0.000) significantly decreased during the follow-up period in NGT, ECMDs and DM groups. Compared with ECMDs and DM groups, the decrease in fasting blood glucose (P=0.029, P=0.000), postprandial blood glucose (P=0.003, P=0.000), and serum IGF-1 (P=0.048, P=0.000) were more significant in DM group.
  
  
  CONCLUSIONS
  Transsphenoidal adenectomy can improve the blood glucose, GH, and IGF-1 levels in patients with growth hormone-secreting pituitary adenoma. Meanwhile,the surgery has a better effect in improving the glucose tolerance status and IGF-1 in patients with preoperatively confirmed DM.
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Yi-lin
authors.initials: YL
authors.lastname: Li
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Xiao-peng
authors.initials: XP
authors.lastname: Guo
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Lu
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lian
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Ren-zhi
authors.initials: RZ
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xing
mesh_terms: D000236:Adenoma; D001786:Blood Glucose; D003920:Diabetes Mellitus; D005947:Glucose; D049912:Growth Hormone-Secreting Pituitary Adenoma; D019382:Human Growth Hormone; D006801:Humans; D007334:Insulin-Like Growth Factor I; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D005947:Glucose