title: Arrhythmia as a cardiac manifestation in MELAS syndrome.
abstract: A 44-year-old female with a diagnosis of mitochondrial myopathy, encephalopathy and stroke-like episodes (MELAS) syndrome had progressive left ventricular hypertrophy (LVH) on echocardiogram. A Holter monitor demonstrated episodes of non-sustained atrial tachycardia, a finding not been previously described in this population. This unique case of MELAS syndrome demonstrates the known associated cardiac manifestation of LVH and the new finding of atrial tachycardia which may represent the potential for subclinical arrhythmia in this population.
authors.affiliation: Arkansas Children's Hospital, Little Rock, AR, United States.
authors.forename: Tamara
authors.initials: T
authors.lastname: Thomas
authors.affiliation: Texas Children's Genetics Clinic, Texas Children's Hospital, Houston, TX, United States.
authors.forename: William J
authors.initials: WJ
authors.lastname: Craigen
authors.affiliation: The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
authors.forename: Ryan
authors.initials: R
authors.lastname: Moore
authors.affiliation: The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
authors.forename: Richard
authors.initials: R
authors.lastname: Czosek
authors.affiliation: The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
authors.forename: John L
authors.initials: JL
authors.lastname: Jefferies
keywords: Arrhythmia; Heart failure; MELAS; Mitochondria