title: Why individual thermo sensation and pain perception varies? Clue of disruptive mutations in TRPVs from 2504 human genome data.
abstract: Every individual varies in character and so do their sensory functions and perceptions. The molecular mechanism and the molecular candidates involved in these processes are assumed to be similar if not same. So far several molecular factors have been identified which are fairly conserved across the phylogenetic tree and are involved in these complex sensory functions. Among all, members belonging to Transient Receptor Potential (TRP) channels have been widely characterized for their involvement in thermo-sensation. These include TRPV1 to TRPV4 channels which reveal complex thermo-gating behavior in response to changes in temperature. The molecular evolution of these channels is highly correlative with the thermal response of different species. However, recent 2504 human genome data suggest that these thermo-sensitive TRPV channels are highly variable and carry possible deleterious mutations in human population. These unexpected findings may explain the individual differences in terms of complex sensory functions.
authors.affiliation: a School of Biological Sciences, National Institute of Science Education and Research, Institute of Physics Campus , Bhubaneswar , Orissa , India.|b School of Biological Sciences, National Institute of Science Education and Research, Jatni Campus , Bhubaneswar , Orissa , India.
authors.forename: Arijit
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: c School of Biotechnology, KIIT University , Bhubaneswar , Orissa , India.
authors.forename: Navneet
authors.initials: N
authors.lastname: Kaur
authors.affiliation: d Molecular Genetic Epidemiology, Deutsches Krebsforschungszentrum (DKFZ) , Heidelberg , Germany.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Kumar
authors.affiliation: a School of Biological Sciences, National Institute of Science Education and Research, Institute of Physics Campus , Bhubaneswar , Orissa , India.|b School of Biological Sciences, National Institute of Science Education and Research, Jatni Campus , Bhubaneswar , Orissa , India.
authors.forename: Chandan
authors.initials: C
authors.lastname: Goswami
mesh_terms: D000818:Animals; D015894:Genome, Human; D006801:Humans; D009154:Mutation; D058748:Pain Perception; D013697:Thermosensing / Q000235:genetics*; D050051:Transient Receptor Potential Channels / Q000235:genetics*
chemical_list: D050051:Transient Receptor Potential Channels
keywords: TRPV channels; channelopathies; human genome; molecular evolution; mutations; physiology; thermosensation