title: No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations.
abstract: A hybrid allele between the carboxyl ester lipase gene (CEL) and its pseudogene, CELP (called CEL-HYB), generated by nonallelic homologous recombination between CEL intron 10 and CELP intron 10', was found to increase susceptibility to chronic pancreatitis in a case-control study of patients of European ancestry. We attempted to replicate this finding in 3 independent cohorts from China, Japan, and India, but failed to detect the CEL-HYB allele in any of these populations. The CEL-HYB allele might therefore be an ethnic-specific risk factor for chronic pancreatitis. An alternative hybrid allele (CEL-HYB2) was identified in all 3 Asian populations (1.7% combined carrier frequency), but was not associated with chronic pancreatitis.
authors.affiliation: Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Etablissement Français du Sang (EFS)-Bretagne, Brest, France; Shanghai Institute of Pancreatic Diseases, Shanghai, China.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Zou
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Etablissement Français du Sang (EFS)-Bretagne, Brest, France; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale (UBO), Brest, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Boulling
authors.affiliation: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Masamune
authors.affiliation: Genomic Research on Complex Diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.
authors.forename: Prachand
authors.initials: P
authors.lastname: Issarapu
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Centre Hospitalier Universitaire (CHU) Brest, Hôpital Morvan, Brest, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Masson
authors.affiliation: Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China.
authors.forename: Xiao-Tian
authors.initials: XT
authors.lastname: Sun
authors.affiliation: Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China.
authors.forename: Liang-Hao
authors.initials: LH
authors.lastname: Hu
authors.affiliation: Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Dai-Zhan
authors.initials: DZ
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Etablissement Français du Sang (EFS)-Bretagne, Brest, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Fichou
authors.affiliation: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Nakano
authors.affiliation: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Hamada
authors.affiliation: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kakuta
authors.affiliation: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kume
authors.affiliation: Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Isayama
authors.affiliation: Genomic Research on Complex Diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.
authors.forename: Sumit
authors.initials: S
authors.lastname: Paliwal
authors.affiliation: Genomic Research on Complex Diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.
authors.forename: K Radha
authors.initials: KR
authors.lastname: Mani
authors.affiliation: Genomic Research on Complex Diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.
authors.forename: Seema
authors.initials: S
authors.lastname: Bhaskar
authors.affiliation: Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.
authors.forename: David N
authors.initials: DN
authors.lastname: Cooper
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Etablissement Français du Sang (EFS)-Bretagne, Brest, France; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale (UBO), Brest, France; Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Centre Hospitalier Universitaire (CHU) Brest, Hôpital Morvan, Brest, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Férec
authors.affiliation: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Tooru
authors.initials: T
authors.lastname: Shimosegawa
authors.affiliation: Genomic Research on Complex Diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India; Human Genetics Division, Genome Institute of Singapore, Biopolis, Singapore; Laboratory of Human and Medical Genetics, Centre for DNA Fingerprinting & Diagnostics (CDFD), Hyderabad, India.
authors.forename: Giriraj R
authors.initials: GR
authors.lastname: Chandak
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Etablissement Français du Sang (EFS)-Bretagne, Brest, France; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale (UBO), Brest, France. Electronic address: Jian-Min.Chen@univ-brest.fr.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China. Electronic address: zhaoshenli@hotmail.com.
authors.forename: Zhao-Shen
authors.initials: ZS
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China. Electronic address: liaozhuan@smmu.edu.cn.
authors.forename: Zhuan
authors.initials: Z
authors.lastname: Liao
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D047668:Inteins; D007564:Japan; D008049:Lipase / Q000097:blood*; D050500:Pancreatitis, Chronic / Q000235:genetics*; D011544:Pseudogenes / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C054621:CEL protein, human; D008049:Lipase
keywords: Disease Susceptibility; Human Genetics; Nonsense-Mediated mRNA Decay; Pancreatic Acinar Cells