title: An extremely indolent T-cell leukemia: an 18-year follow-up.
abstract: T-cell prolymphocytic leukemia (T-PLL) is a rare malignancy that comprises about 2% of all mature lymphoid neoplasms. Patients usually present with prominent peripheral blood lymphocytosis, splenomegaly, hepatomegaly, lymphadenopathy, B symptoms, and occasionally with skin lesions.¹ The disease follows an aggressive clinical course with rapid progression and typically has a median survival of less than 1 year. In some cases, the disease is indolent for a period of time before becoming aggressive.² In 2002, 7 years after initial diagnosis in 1995, the case discussed herein was reported as a rare, indolent form of T-PLL.³ We now present 11 additional years of follow-up of this case, during which time the patient remained asymptomatic with respect to his lymphoid neoplasm.
authors.affiliation: Department of Medicine, Lehigh Valley Hospital, Allentown, Pennsylvania, USA. samuel.adediran@lvhn.org.
authors.forename: Samuel
authors.initials: S
authors.lastname: Adediran
authors.affiliation: Department of Pathology and Laboratory Medicine, Lehigh Valley Hospital, Allentown, Pennsylvania, USA.
authors.forename: Dennis
authors.initials: D
authors.lastname: Cornfield
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Bagg
authors.affiliation: Department of Medicine, Lehigh Valley Hospital, Allentown, Pennsylvania, USA.|Division of Hematology/Medical Oncology, Lehigh Valley Hospital, Allentown, Pennsylvania, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Agostino
keywords: CLL; T-PLL; T-cell neoplasm; indolent