title: Mental State Decoding in Adolescent Boys with Major Depressive Disorder versus Sex-Matched Healthy Controls.
abstract: BACKGROUND
  Several adult depression studies have investigated mental state decoding, the basis for theory of mind, using the Reading the Mind in the Eyes Test. Findings have been mixed, but a comprehensive study found a greater severity of depression to be associated with poorer mental state decoding. Importantly, there has yet to be a similar study of adolescent depression. Converging evidence suggests that atypical mental state decoding may have particularly profound effects for psychosocial functioning among depressed adolescent boys.
  
  
  METHODS
  Adolescent boys with major depressive disorder (MDD, n = 33) and sex-matched healthy controls (HCs, n = 84) completed structured clinical interviews, self-report measures of psychopathology and the Child Eyes Test (CET).
  
  
  RESULTS
  The MDD group performed significantly better than HCs on the CET overall (p = 0.002), underscored by greater accuracy for negatively valenced items (p = 0.003). Group differences on items depicting positive (p = 0.129) and neutral mental states (p = 0.081) were nonsignificant.
  
  
  CONCLUSIONS
  Enhanced mental state decoding among depressed adolescent boys may play a role in the maintenance of and vulnerability to adolescent depression. Findings and implications are discussed. Limitations of this study include a reliance on self-report data for HC boys, as well as a lack of 'pure' depression among the boys with MDD.
authors.affiliation: University of Houston, Houston, Tex., USA.
authors.forename: William
authors.initials: W
authors.lastname: Mellick
authors.forename: Carla
authors.initials: C
authors.lastname: Sharp
mesh_terms: D000293:Adolescent; D003865:Major Depressive Disorder / Q000523:psychology*; D004192:Discrimination, Psychological; D006801:Humans; D008297:Male; D057566:Self Report; D012938:Social Perception; D014796:Visual Perception / Q000502:physiology*