title: Association of Quadriceps Muscle Fat With Isometric Strength Measurements in Healthy Males Using Chemical Shift Encoding-Based Water-Fat Magnetic Resonance Imaging.
abstract: Magnetic resonance-based assessment of quadriceps muscle fat has been proposed as surrogate marker in sarcopenia, osteoarthritis, and neuromuscular disorders. We presently investigated the association of quadriceps muscle fat with isometric strength measurements in healthy males using chemical shift encoding-based water-fat magnetic resonance imaging. Intermuscular adipose tissue fraction and intramuscular proton density fat fraction correlated significantly (P < 0.05) with isometric strength (up to r = -0.83 and -0.87, respectively). Reproducibility of intermuscular adipose tissue fraction and intramuscular proton density fat fraction was 1.5% and 5.7%, respectively.
authors.affiliation: From the *Institut für Radiologie, Klinikum rechts der Isar, †Fakultät für Sport- und Gesundheitswissenschaften, Lehrstuhl Biomechanik im Sport, and ‡Abteilung für Neuroradiologie, Klinikum rechts der Isar, Technische Universität München, Munich; §Philips Research Laboratory; and ∥Philips Healthcare, Hamburg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Baum
authors.forename: Stephanie
authors.initials: S
authors.lastname: Inhuber
authors.forename: Michael
authors.initials: M
authors.lastname: Dieckmeyer
authors.forename: Christian
authors.initials: C
authors.lastname: Cordes
authors.forename: Stefan
authors.initials: S
authors.lastname: Ruschke
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Klupp
authors.forename: Pia M
authors.initials: PM
authors.lastname: Jungmann
authors.forename: Rosanna
authors.initials: R
authors.lastname: Farlock
authors.forename: Holger
authors.initials: H
authors.lastname: Eggers
authors.forename: Hendrik
authors.initials: H
authors.lastname: Kooijman
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Rummeny
authors.forename: Ansgar
authors.initials: A
authors.lastname: Schwirtz
authors.forename: Jan S
authors.initials: JS
authors.lastname: Kirschke
authors.forename: Dimitrios C
authors.initials: DC
authors.lastname: Karampinos
mesh_terms: D050154:Adiposity / Q000502:physiology; D000328:Adult; D001834:Body Water / Q000000981:diagnostic imaging / Q000502:physiology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000502:physiology*; D007537:Isometric Contraction / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D053580:Muscle Strength / Q000502:physiology*; D052097:Quadriceps Muscle / Q000000981:diagnostic imaging* / Q000502:physiology*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity