title: Analysis of biostructural changes, dynamics, and interactions - Small-angle X-ray scattering to the rescue.
abstract: Solution small angle X-ray scattering from biological macromolecules (BioSAXS) plays an increasingly important role in biostructural research. The analysis of complex protein mixtures, dynamic equilibriums, intrinsic disorder and evolving structural processes is facilitated by SAXS data, either in stand-alone applications, or with SAXS taking a prominent role in hybrid biostructural analysis. This is not the least due to the significant advances in both hardware and software that have taken place in particular at the large-scale facilities. Here, recent developments and the future potential of BioSAXS are reviewed, exemplified by numerous examples of elegant applications to challenging systems.
authors.affiliation: Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, 2100 Copenhagen, Denmark. Electronic address: bente.vestergaard@sund.ku.dk.
authors.forename: Bente
authors.initials: B
authors.lastname: Vestergaard
mesh_terms: D003198:Computer Simulation; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction / Q000379:methods*
chemical_list: D011506:Proteins
keywords: Advanced sample environments; Complex structural analysis; Hybrid biostructural analysis; Intrinsically disordered proteins; Small angle X-ray scattering