title: Annexin A5 haplotype M2 is not a risk factor for recurrent spontaneous abortion in Northern Europe: is there sufficient evidence?
abstract: The M2 haplotype of the annexin A5 gene is a well-recognized predisposition factor for recurrent spontaneous abortion (RSA). A recent publication by Nagirnaja et al. (2015) in PLoS One discusses the risk role of the M2 haplotype for RSA in cases compared with controls of North European extraction and arrives at a negative result. As a number of previous and fairly recent studies have supported the proposed involvement of the M2 haplotype in the cause of idiopathic RSA, this commentary aims to highlight problematic issues in the above publication. It is the opinion of the authors that the study by Nagirnaja et al. (2015) does not generate adequate proof of the absence of RSA risk, attributable to carriage of the M2 haplotype.
authors.affiliation: Institute of Human Genetics, University of Muenster, Vesaliusweg 12-14, 48149 Muenster, Germany. Electronic address: markoff@uni-muenster.de.
authors.forename: Arseni
authors.initials: A
authors.lastname: Markoff
authors.affiliation: Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kurahashi
authors.affiliation: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia 71013, Italy.
authors.forename: Elvira
authors.initials: E
authors.lastname: Grandone
authors.affiliation: Institute of Human Genetics, University of Muenster, Vesaliusweg 12-14, 48149 Muenster, Germany.
authors.forename: Nadja
authors.initials: N
authors.lastname: Bogdanova
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D017304:Annexin A5 / Q000235:genetics*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011401:Promoter Regions, Genetic
chemical_list: D017304:Annexin A5
keywords: ANXA5; M2/ANXA5; annexin A5; recurrent miscarriage; risk factor