title: Effectiveness of Systemic Fluconazole in Adult Patients With Asymptomatic Candiduria: A Systematic Review and Meta-Analysis.
abstract: Asymptomatic candiduria is a common finding in hospitalized patients. Its management modalities are still a matter of debate. Urinary catheter should be removed or replaced in all cases. In the current meta-analysis, we aimed to compare 2 different strategies in term of candida clearance from the urinary tract: Systemic fluconazole versus conservative management. A systematic search was performed in Pubmed, Web of science, and Cochrane Library database by 2 investigators. Three studies were included (421 patients). Data were extracted and the quality of each study was assessed. Systemic fluconazole was associated with a significantly higher short-term clearance of the funguria after 14 days of treatment [odds ratio = 0.43; confidence interval (CI) 95% (0.26-0.65)]. No significant heterogeneity was found among the included studies (Q statistic test = 0.38; I = 0). In conclusion, fluconazole significantly hasten short-term candida clearance from the urinary tract.
authors.affiliation: Department of Intensive Care, King Hamed University Hospital, Al Muharaq, Bussaiteen, Kingdom of Bahrain.
authors.forename: Anis
authors.initials: A
authors.lastname: Chaari
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ismail
authors.forename: Karim
authors.initials: K
authors.lastname: Abdel Hakim
authors.forename: Tarek
authors.initials: T
authors.lastname: Said Mahmoud
authors.forename: Kamel
authors.initials: K
authors.lastname: Boussalmi
authors.forename: Ahmed
authors.initials: A
authors.lastname: Elsaka
authors.forename: Mariem
authors.initials: M
authors.lastname: Al Khaja
authors.forename: Vipin
authors.initials: V
authors.lastname: Kauts
authors.forename: William Francis
authors.initials: WF
authors.lastname: Casey
mesh_terms: D061605:Administration, Intravenous; D000284:Administration, Oral; D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D058345:Asymptomatic Infections; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology / Q000628:therapy*; D000072700:Conservative Treatment; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000382:microbiology / Q000628:therapy*
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole