title: Comparison of Risk Factor between Lacunar Stroke and Large Artery Atherosclerosis Stroke: A Cross-Sectional Study in China.
abstract: BACKGROUND
  Stroke is the second most common cause of mortality in China. Although most subtypes of ischemic stroke share similar risk factors, they have different etiologies. Our study aimed to evaluate the different risk factor profiles between the stroke subtypes, lacunar infarcts (LI) and large-artery atherosclerosis (LAA), and clarify the characteristics of current acute ischemic stroke in China.
  
  
  METHODS
  In this cross-sectional study, we analyzed the clinical characteristics of 1982 patients with acute ischemic stroke who were admitted to the neurology department at the Peking University First Hospital between 2007 and 2014. Ischemic stroke was further classified into LAA, LI, cardioembolism (CE) and undetermined causes of infarction (UDI) according to TOAST classification. Demographic characteristics, risk factors, as well as the findings of laboratory and imaging tests of 1773 patients with LAA and LI, were analyzed by univariate and multivariate logistic analysis.
  
  
  RESULTS
  Of the 1982 ischemic stroke patients included in this study, 1207 were diagnosed with LAA, 566 with LI, 173 with cardioembolism (CE) and 36 with undetermined causes of infarction (UDI). By comparing the risk factors in multivariate logistic regression analysis, hypertension [odds ratio (OR) = 1.832] and white matter leukoaraiosis (WML) (OR = 1.865) were found to be more strongly correlated with LI than LAA. Low density lipoprotein- cholesterol (LDL-c) (OR = 0.774) were more strongly related to LAA than LI.
  
  
  CONCLUSIONS
  This study found that hypertension and WML were more strongly correlated with LI than LAA. LDL-c was more strongly related to LAA than LI.
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Pu
authors.initials: P
authors.lastname: Lv
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Haiqiang
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Peng
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Chenghe
authors.initials: C
authors.lastname: Fan
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Teng
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Yining
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000368:Aged; D001158:Arteries / Q000378:metabolism / Q000473:pathology*; D050197:Atherosclerosis / Q000150:complications* / Q000378:metabolism; D002545:Brain Ischemia / Q000150:complications / Q000378:metabolism; D002681:China; D008078:Cholesterol, LDL / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D059409:Stroke, Lacunar / Q000209:etiology* / Q000378:metabolism
chemical_list: D008078:Cholesterol, LDL