title: Nanofibrous Synthetic Dural Patch for Skull Base Defects: Preliminary Experience for Reconstruction after Extended Endonasal Approaches.
abstract: Setting One of the consequences of the widespread use of endoscopic endonasal approaches (EEA) to skull base pathologies is the management of complex skull base defects. Nowadays, the gold standard is a multilayer closure that reproduces the physiological tissue barriers. Several techniques have been described in the literature; however, skull base reconstruction after EEA still represents a matter of debate, especially after extended EEA. A watertight closure is paramount to prevent cerebrospinal fluid leak and meningitis. Design Regarding this issue, we present our experience with a new synthetic dural patch, ReDura (Medprin Biotech, La Mirada, California, United States), as a subdural inlay in three patients who underwent endoscopic endonasal removal of sellar and suprasellar lesions. Conclusions ReDura patch showed the same versatility of autologous iliotibial tract. A dural patch that easily adapts to all defects, revealed to be a useful tool for performing watertight closure, possibly in a short operative time, after endoscopic approaches.
authors.affiliation: Division of Neurosurgery, Department of Neuroscience, University of Torino, Turin, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Zenga
authors.affiliation: Division of Neurosurgery, Department of Neuroscience, University of Torino, Turin, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Tardivo
authors.affiliation: Division of Neurosurgery, Department of Neuroscience, University of Torino, Turin, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Pacca
authors.affiliation: 1st Division of ENT, Department of Surgical Sciences, University of Torino, Turin, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Garzaro
authors.affiliation: Division of Neurosurgery, Department of Neuroscience, University of Torino, Turin, Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Garbossa
authors.affiliation: Division of Neurosurgery, Department of Neuroscience, University of Torino, Turin, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ducati
keywords: cerebrospinal fluid leak; dural substitute; extended endoscopic endonasal approach