title: Scoring System Development and Validation for Prediction Choledocholithiasis before Open Cholecystectomy.
abstract: BACKGROUND
  Accurate precholecystectomy detection of concurrent asymptomatic common bile duct stones (CBDS) is key in the clinical decision-making process. The standard preoperative methods used to diagnose these patients are often not accurate enough.
  
  
  OBJECTIVE
  The aim of the study was to develop a scoring model that would predict CBDS before open cholecystectomy.
  
  
  METHODS
  We retrospectively collected preoperative (demographic, biochemical, ultrasonographic) and intraoperative (intraoperative cholangiography) data for 313 patients at the department of General Surgery at Gornji Milanovac from 2004 to 2007. The patients were divided into a derivation (213) and a validation set (100). Univariate and multivariate regression analysis was used to determine independent predictors of CBDS. These predictors were used to develop scoring model. Various measures for the assessment of risk prediction models were determined, such as predictive ability, accuracy, the area under the receiver operating characteristic curve (AUC), calibration and clinical utility using decision curve analysis.
  
  
  RESULTS
  In a univariate analysis, seven risk factors displayed significant correlation with CBDS. Total bilirubin, alkaline phosphatase and bile duct dilation were identified as independent predictors of choledocholithiasis. The resultant total possible score in the derivation set ranged from 7.6 to 27.9. Scoring model shows good discriminatory ability in the derivation and validation set (AUC 94.3 and 89.9%, respectively), excellent accuracy (95.5%), satisfactory calibration in the derivation set, similar Brier scores and clinical utility in decision curve analysis.
  
  
  CONCLUSIONS
  Developed scoring model might successfully estimate the presence of choledocholithiasis in patients planned for elective open cholecystectomy.
authors.forename: Tomislav
authors.initials: T
authors.lastname: Pejović
authors.forename: Miroslav M
authors.initials: MM
authors.lastname: Stojadinović
mesh_terms: D000328:Adult; D000368:Aged; D002763:Cholecystectomy; D042883:Choledocholithiasis / Q000175:diagnosis* / Q000601:surgery*; D000066491:Clinical Decision-Making; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment