title: [Allopurinol hypersensitivity syndrome. A report of two cases].
abstract: Patients in treatment with allopurinol are in risk of having life threatening adverse reactions particularly at the beginning of the treatment. Two percent of the patients prescribed with this drug have associated severe cutaneous adverse reactions. We present two cases of allopurinol hypersensitivity syndrome in mexican patients in which asymptomatic hyperuricemia was the indication to its use. The general physician and the specialist must be alert of this syndrome that causes elevate morbidity and mortality.
authors.affiliation: Departamento de Dermatología, Hospital Central "Dr. Ignacio Morones Prieto", San Luis Potosí, San Luis Potosí, México. torresmab@yahoo.com.mx.
authors.forename: Adriana
authors.initials: A
authors.lastname: Rodríguez-Arámbula
authors.forename: Elsa
authors.initials: E
authors.lastname: Arenas-Velázquez
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Castanedo-Cázares
authors.forename: Diana
authors.initials: D
authors.lastname: Hernández-Blanco
authors.forename: Cuauhtémoc
authors.initials: C
authors.lastname: Oros-Ovalle
authors.forename: Bertha
authors.initials: B
authors.lastname: Torres-Álvarez
mesh_terms: D000293:Adolescent; D000493:Allopurinol / Q000009:adverse effects* / Q000627:therapeutic use; D063926:Drug Hypersensitivity Syndrome / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006074:Gout Suppressants / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy; D008297:Male; D055815:Young Adult
chemical_list: D006074:Gout Suppressants; D000493:Allopurinol
keywords: Allopurinol; Drug hypersensitivity; Drug hypersensitivity syndrome