title: [Skin reaction to carbamazepine or DRESS syndrome: a case presentation].
abstract: Carbamazepine is a frequently used drug that can produce adverse reactions like vertigo, somnolence and severe skin reactions like Drug Rash with Eosinophilia and Systemic Symptoms Syndrome (DRESS Syndrome). This syndrome is characterized by a late-appearing, slow-progressing cutaneous eruption accompanied by atypical lymphocytes, eosinophilia, and systemic symptoms such as fever, lymphadenopathy, hepatic compromise, and renal dysfunction that can be severe enough to cause death. We present a case that aims to highlight the importance of an early diagnosis of DRESS syndrome to adjust therapy and improve survival. The patient is a female patient prescribed carbamazepine for trigeminal neuralgia who presented with skin lesions, which were initially attributed to a hypersensitivity reaction. The lesions worsened in spite of treatment and systemic symptoms ensued. A diagnosis of DRESS syndrome was proposed and steroid treatment was initiated with rapid improvement.
authors.affiliation: Policlínico Hospital Alberto Fernández Valdés, Santa Cruz del Norte, Mayabeque, Cuba. Address: Avenida 11, Edificio 22, Apartamento 1, Santa Cruz del Norte, Mayabeque, Cuba. Email: emigdio@infomed.sld.cu.
authors.forename: Emigdio Jesús
authors.initials: EJ
authors.lastname: Cabrera Fundora
authors.affiliation: Policlínico Hospital Alberto Fernández Valdés, Santa Cruz del Norte, Mayabeque, Cuba.
authors.forename: Yuliet
authors.initials: Y
authors.lastname: Cabrera Osorio
authors.affiliation: Policlínico Hospital Alberto Fernández Valdés, Santa Cruz del Norte, Mayabeque, Cuba.
authors.forename: Claudia
authors.initials: C
authors.lastname: Cabrera Osorio
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects*; D002220:Carbamazepine / Q000008:administration & dosage / Q000009:adverse effects*; D063926:Drug Hypersensitivity Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D014277:Trigeminal Neuralgia / Q000188:drug therapy
chemical_list: D018712:Analgesics, Non-Narcotic; D002220:Carbamazepine
keywords: DRESS syndrome; carbamazepine; drug eruptions; maculopapular drug eruption