title: Mutual Cooperation in the Formal Allyl Alcohol Nucleophilic Substitution and Hydration of Alkynes for the Construction of γ-Substituted Ketones.
abstract: Mutual cooperation in the formal allyl alcohol nucleophilic substitution reaction and hydration of an alkyne has been utilized in the presence of a gold catalyst to give a series of γ-functionalized ketones with high to excellent yields. This reaction actually involved an intramolecular O-H insertion cyclization of an alkyne to form the dihydrofuran intermediate, which was followed by the nucleophilic addition ring-opening of a dihydrofuran to give the target compound.
authors.affiliation: The College of Chemistry, the State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Wiejin Road 94#, Tianjin, 300071, P. R. China.
authors.forename: Kaimeng
authors.initials: K
authors.lastname: Huang
authors.affiliation: The College of Chemistry, the State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Wiejin Road 94#, Tianjin, 300071, P. R. China.
authors.forename: Hongkai
authors.initials: H
authors.lastname: Wang
authors.affiliation: The College of Chemistry, the State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Wiejin Road 94#, Tianjin, 300071, P. R. China. lijing@nankai.edu.cn.
authors.forename: Lingyan
authors.initials: L
authors.lastname: Liu
authors.affiliation: The College of Chemistry, the State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Wiejin Road 94#, Tianjin, 300071, P. R. China.
authors.forename: Weixing
authors.initials: W
authors.lastname: Chang
authors.affiliation: The College of Chemistry, the State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Wiejin Road 94#, Tianjin, 300071, P. R. China. liulingyan@nankai.edu.cn.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 300071, P. R. China. liulingyan@nankai.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
keywords: 1,5-enynols; cyclization; gold catalysis; hydration; nucleophilic substitution; ring-opening reactions