title: Systemic Inflammation and Autoimmunity in Women with Chronic Endometritis.
abstract: To determine in women with recurrent pregnancy loss (RPL) and/or implantation failure (RIF) the prevalence of chronic endometritis (CE), systemic inflammation and autoimmunity, and whether they relate.
  
  
  
  This retrospective study examined inflammatory (adiponectin, CRP, leptin, and IL6) and autoimmune (total immunoglobulins, ANA, thyroid antibodies, antiphospholipid antibodies) markers in a group of 55 women with RPL/RIF. A diagnosis of CE was reached by endometrial biopsy, demonstrating CD138-positive plasma cells on histology. The prevalence of markers of systemic inflammation and autoimmunity was compared between women with and without CE.
  
  
  
  Among all RPL/RIF patients, 32.7% demonstrated at least one positive inflammatory marker, 61.8% at least one autoimmune marker, and 45.5% CE. Moreover, CE patients did not differ in systematic inflammatory or autoimmune profiles from those without CE.
  
  
  
  Endometritis and elevated inflammatory and autoimmune markers are common in women with RPL/RIF, but endometritis cannot be predicted based on either peripheral inflammatory or autoimmune markers.
authors.affiliation: The Center for Human Reproduction, New York, NY, USA.|Wake Forest School of Medicine, Winston-Salem, NC, USA.
authors.forename: Vitaly A
authors.initials: VA
authors.lastname: Kushnir
authors.affiliation: Lenox Hill Hospital, New York, NY, USA.
authors.forename: Shirley
authors.initials: S
authors.lastname: Solouki
authors.affiliation: Sackler School of Medicine, Tel Aviv, Israel.
authors.forename: Tal
authors.initials: T
authors.lastname: Sarig-Meth
authors.affiliation: Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Mario G
authors.initials: MG
authors.lastname: Vega
authors.affiliation: The Center for Human Reproduction, New York, NY, USA.|University of Kansas Medical Center, Kansas City, KS, USA.
authors.forename: David F
authors.initials: DF
authors.lastname: Albertini
authors.affiliation: The Center for Human Reproduction, New York, NY, USA.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Darmon
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Liane
authors.initials: L
authors.lastname: Deligdisch
authors.affiliation: The Center for Human Reproduction, New York, NY, USA.|Albert Einstein College of Medicine, Bronx, NY, USA.|Foundation for Reproductive Medicine, New York, NY, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Barad
authors.affiliation: The Center for Human Reproduction, New York, NY, USA.|Foundation for Reproductive Medicine, New York, NY, USA.|The Rockefeller University, New York, NY, USA.
authors.forename: Norbert
authors.initials: N
authors.lastname: Gleicher
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology*; D052242:Adiponectin / Q000378:metabolism; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002908:Chronic Disease; D010064:Embryo Implantation; D004716:Endometritis / Q000453:epidemiology*; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008875:Middle Aged; D015995:Prevalence; D012008:Recurrence; D012189:Retrospective Studies; D017211:Treatment Failure; D014481:United States / Q000453:epidemiology
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001323:Autoantibodies; D018836:Inflammation Mediators; D015850:Interleukin-6; D002097:C-Reactive Protein
keywords: Autoimmunity; chronic endometritis; infertility; inflammation; recurrent implantation failure; recurrent pregnancy loss