title: Inverse Relationship Between Helicobacter Pylori Infection and Asthma Among Adults Younger than 40 Years: A Cross-Sectional Study.
abstract: Recent studies have suggested that Helicobacter pylori could prevent allergic disease, particularly in children. However, whether this is true in adults is controversial. The aim of this study was to investigate whether there is negative association between H. pylori infection and asthma among adults in an area with a high prevalence of H. pylori.This was a cross-sectional study using 2011 health surveillance data. Blood samples were taken from all participants to measure serum H. pylori IgG status. Information on demographics, socioeconomic status, and medical history, including asthma and other allergic conditions were collected by a questionnaire.Of the 15,032 patients, 9492 (63.1%) had a history of H. pylori infection, 359 (2.4%) had asthma, and 3277 (21.8%) had other allergic conditions. H. pylori infection was positively correlated with age (OR, 1.050; 95% CI, 1.047-1.053, P < 0.001). Asthma history was positively correlated with age (OR, 1.022; 95% CI, 1.013-1.032, P < 0.001). H. pylori and age were shown to have interaction on asthma in the total participants (OR, 1.041; 95% CI, 1.021-1.062, P < 0.001). In subgroup analysis, H. pylori infection among those < 40 years old was inversely correlated with asthma (OR, 0.503; 95% CI, 0.280-0.904, P = 0.021). Other allergic conditions were not related with H. pylori infection among the total and those <40 years old.The inverse association between H. pylori infection and asthma among young adults suggests that the underlying immune mechanism induced by H. pylori infection may affect allergic reactions associated with asthma in young adults.
authors.affiliation: From the Seoul National University Hospital, Healthcare System Gangnam Center, Healthcare Research Institute, Seoul (JHL, SHL, JSK, S-HC); Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do (NK, CMS, Y-SC); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu (J-WK); and Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea (LJH, NK, JSK, HCJ).
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Lim
authors.forename: Nayoung
authors.initials: N
authors.lastname: Kim
authors.forename: Seon Hee
authors.initials: SH
authors.lastname: Lim
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Kwon
authors.forename: Cheol Min
authors.initials: CM
authors.lastname: Shin
authors.forename: Yoon-Seok
authors.initials: YS
authors.lastname: Chang
authors.forename: Joo Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Hyun Chae
authors.initials: HC
authors.lastname: Jung
authors.forename: Sang-Heon
authors.initials: SH
authors.lastname: Cho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D001249:Asthma / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D003430:Cross-Sectional Studies; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G