title: Hydrothermal fabrication of porous hollow hydroxyapatite microspheres for a drug delivery system.
abstract: Porous hollow hydroxyapatite microspheres (PHHMs) are the promising biomaterials, owing to their excellent biocompatibility, biodegradability and bioactivity. PHHMs have been used as drug controlled carriers due to their advantages such as large drug loading capacity, nanochannels for drug loading and release and high specific surface area. In this study, PHHMs were prepared successfully in Na2HPO4 solution by an anion-exchange process using vaterite CaCO3 through a hydrothermal method. The previous vaterite CaCO3 was synthesized by a polymer-templated method in the poly(styrene sulfonic acid) sodium salt (PSS) aqueous solutions. The PHHMs have a size distribution from 0.8 to 2.0 μm, with an average pore size of about 24.3 nm. The wall of PHHMs is constructed with building units of hydroxyapatite nanofibers with an average length of 300 nm and an average width of 20 nm. The PHHMs displayed a high drug loading capacity and pH-responsive sustained-controlled drug release behavior when we used doxorubicin hydrochloride (DOX) as a loading drug. Moreover, the controlled drug release system showed a high ability to kill cancer cells and less damage to normal cells. These results indicated that PHHMs are promising for applications in various biomedical fields such as drug delivery system and oncotherapy.
authors.affiliation: Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Lai
authors.affiliation: Institute of Biomaterials and Marine Biological Resources, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Cen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Institute of Biomaterials and Marine Biological Resources, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Ren
authors.affiliation: Institute of Natural Science, Yonsei University, Seoul 120-749, Republic of Korea.
authors.forename: In-Seop
authors.initials: IS
authors.lastname: Lee
authors.affiliation: Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, China; Institute of Biomaterials and Marine Biological Resources, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address: kongxiangdong@gmail.com.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Kong
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000633:toxicity; D002119:Calcium Carbonate / Q000737:chemistry; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D016062:Porosity; D014961:X-Ray Diffraction
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D004317:Doxorubicin; D017886:Durapatite; D002119:Calcium Carbonate
keywords: Calcium carbonate; Drug delivery system; Hollow microspheres; Hydroxyapatite