title: Influence of Cytokines and Soluble Receptors in the Quality of Life and Functional Capacity of Workers Exposed to Silica.
abstract: OBJECTIVE
  The aim of the study was to evaluate the plasma levels of inflammatory mediators in subjects exposed to silica, with and without silicosis compared with unexposed control group; and to check the association between inflammatory mediators with pulmonary function, quality of life, functional capacity, and dyspnea grade.
  
  
  METHODS
  Inflammatory mediators were measured by enzyme-linked immunosorbent assay. There were 30 subjects exposed to silica and 24 control group.
  
  
  RESULTS
  Interleukin-6 plasma levels were higher in subjects exposed to silica with and without silicosis than in the control group. There was a positive correlation between radiological severity and the quality of life, whereas there was a negative correlation between radiological severity and pulmonary function. A negative correlation between sTNFR1 plasma level and functional capacity was found. Interleukin-10 was negatively correlated with the quality of life total score and was positively correlated with the functional capacity and pulmonary function.
authors.affiliation: Post Graduate Multicenter Program in Physiological Sciences (Dr Braz, Dr Lacerda, Dr Mendonça), Brazilian Society of Physiology, São Paulo; Inflammation and Metabolism Laboratory (Dr Braz, Dr Mendonça), UFVJM, Diamantina; Medical Doctor of State Reference Center in Occupational Health (Dr Carneiro), the Clinics Hospital, UFMG, Belo Horizonte; Department of Physical Therapy (Dr de Avelar), UFSC, Araranguá; Immunopharmacology Laboratory (Dr de Miranda, Dr Mauro Martins Teixeira, Dr Antônio Lúcio Teixeira), UFMG, Belo Horizonte, Brazil.
authors.forename: Nayara Felicidade Tomaz
authors.initials: NF
authors.lastname: Braz
authors.forename: Ana Paula Scalia
authors.initials: AP
authors.lastname: Carneiro
authors.forename: Núbia Carelli Pereira de
authors.initials: NC
authors.lastname: Avelar
authors.forename: Aline Silva de
authors.initials: AS
authors.lastname: Miranda
authors.forename: Ana Cristina Rodrigues
authors.initials: AC
authors.lastname: Lacerda
authors.forename: Mauro Martins
authors.initials: MM
authors.lastname: Teixeira
authors.forename: Antônio Lúcio
authors.initials: AL
authors.lastname: Teixeira
authors.forename: Vanessa Amaral
authors.initials: VA
authors.lastname: Mendonça
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood*; D004417:Dyspnea / Q000209:etiology; D005080:Exercise Test; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D011788:Quality of Life; D013902:Radiography, Thoracic; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D012822:Silicon Dioxide / Q000633:toxicity*; D012829:Silicosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016138:Walking / Q000502:physiology
chemical_list: D016207:Cytokines; D053583:Interleukin-1beta; D015850:Interleukin-6; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D016753:Interleukin-10; D012822:Silicon Dioxide