title: Association of serum immunoglobulin-G to Porphyromonas gingivalis with acute cerebral infarction in the Chinese population.
abstract: OBJECTIVE
  There is evidence supporting an association between ischemic stroke and periodontitis in western countries. Differing genetic backgrounds and lifestyles among populations may affect this association. The aim of our study was to determine whether antibody titers to Porphyromonas gingivalis are associated with acute cerebral infarction in the Chinese population.
  
  
  METHODS
  This case-control study was conducted on 88 acute cerebral infarction patients and 40 healthy control subjects. Serum immunoglobulin-G (IgG) antibody to P. gingivalis was analyzed by enzyme-linked immune sorbent assay. Serum lipids were determined with the automatic biochemical analyzer. Fibrinogen was measured using automated coagulation analyzer. High-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were quantified using commercial ELISA kits. The intima-media thickness of the common carotid arteries (IMT-CCA) was measured by ultrasonography.
  
  
  RESULTS
  The results showed that P. gingivalis IgG antibody levels were significantly higher in acute cerebral infarction cases than in healthy controls (mean ± standard deviation, 11.06 ± 1.49 vs. 9.15 ± 1.70, P < 0.001). There were significant correlations of P. gingivalis IgG titer with total cholesterol (r = 0.34, P = 0.001), low-density lipoprotein (r = 0.39, P < 0.001), apolipoprotein-B (r = 0.30, P = 0.004), hs-CRP (r = 0.35, P = 0.001), IL-6 (r = 0.27, P = 0.011), and IMT-CCA (left: r = 0.306, P = 0.004; right: r = 0.241, P = 0.024).
  
  
  CONCLUSIONS
  Antibody titers to P. gingivalis are associated with acute cerebral infarction in the Chinese population.
authors.affiliation: Department of Periodontology, Stomatological Hospital, Jilin University, Changchun, China; Department of Periodontology, Tianjin Stomatological Hospital, Nankai University, Tianjin, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Periodontology, Stomatological Hospital, Jilin University, Changchun, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.affiliation: Department of General Dentistry, Stomatological Hospital, Tianjin Medical University, Tianjin, China.
authors.forename: Youli
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Emergency, Stomatological Hospital, Jilin University, Changchun, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
keywords: Antibody; Porphyromonas gingivalis; cerebral infarction; periodontitis