title: Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study.
abstract: The association between maternal cadmium (Cd) exposure during pregnancy and the increased risk of fetal growth restriction (FGR) remains controversial. The present study evaluated the association between maternal serum Cd level and risk of small for gestational age (SGA) infants in a Chinese population. The present study analyzed a subsample of the C-ABCS cohort that recruited 3254 eligible mother-and-singleton-offspring pairs. Maternal serum Cd level during pregnancy was measured by graphite furnace atomic absorption spectrometry. The rate and odds ratio (OR) for SGA infant were calculated. The rate for SGA infant was 10.6% among subjects with H-Cd (≥1.06 μg/L), significantly higher than 7.5% among subjects with L-Cd (<1.06 μg/L). OR was 1.45 (95% CI: 1.11, 1.90; P = 0.007) among subjects with H-Cd. Adjusted OR for SGA infants was 1.43 (95% CI: 1.09, 1.88; P = 0.007) among subjects with H-Cd. Taken together, we observe the fact that maternal Cd exposure at middle gestational stage, elevates the risk of SGA in contrast to early gestational stage. The present results might be interesting and worth more discussing, and guarantee to further studies.
authors.affiliation: School of Public Health, Anhui Medical University; Hefei, China.|Anhui Provincial Key Laboratory of Population Health &Aristogenics, Hefei, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Public Health, Anhui Medical University; Hefei, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Public Health, Anhui Medical University; Hefei, China.
authors.forename: Yong-Fang
authors.initials: YF
authors.lastname: Hu
authors.affiliation: School of Public Health, Anhui Medical University; Hefei, China.|Anhui Provincial Key Laboratory of Population Health &Aristogenics, Hefei, China.
authors.forename: Jia-Hu
authors.initials: JH
authors.lastname: Hao
authors.affiliation: School of Public Health, Anhui Medical University; Hefei, China.|Anhui Provincial Key Laboratory of Population Health &Aristogenics, Hefei, China.
authors.forename: Yuan-Hua
authors.initials: YH
authors.lastname: Chen
authors.affiliation: School of Public Health, Anhui Medical University; Hefei, China.|Anhui Provincial Key Laboratory of Population Health &Aristogenics, Hefei, China.
authors.forename: Pu-Yu
authors.initials: PY
authors.lastname: Su
authors.affiliation: School of Public Health, Anhui Medical University; Hefei, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Fu
authors.affiliation: School of Public Health, Anhui Medical University; Hefei, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yu
authors.affiliation: School of Public Health, Anhui Medical University; Hefei, China.
authors.forename: Gui-Bin
authors.initials: GB
authors.lastname: Zhang
authors.affiliation: School of Public Health, Anhui Medical University; Hefei, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Public Health, Anhui Medical University; Hefei, China.|Anhui Provincial Key Laboratory of Population Health &Aristogenics, Hefei, China.
authors.forename: Fang-Biao
authors.initials: FB
authors.lastname: Tao
authors.affiliation: School of Public Health, Anhui Medical University; Hefei, China.|Anhui Provincial Key Laboratory of Population Health &Aristogenics, Hefei, China.
authors.forename: De-Xiang
authors.initials: DX
authors.lastname: Xu
mesh_terms: D000328:Adult; D002104:Cadmium / Q000097:blood*; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D006801:Humans; D007236:Infant, Small for Gestational Age; D011247:Pregnancy
chemical_list: D002104:Cadmium