title: [From clinical trials to clinical practice. Experience with rivaroxaban in the anticoagulant treatment of patients with non-valvular atrial fibrillation].
abstract: Despite the information provided by clinical trials is important, there are relevant clinical differences between those patients included in clinical trials and data of daily outpatient clinics. As a result, in some cases, the results of randomized clinical trials could not be directly applied to clinical practice. In this context, to perform «real-life» registries is mandatory. In the ROCKET-AF study, rivaroxaban, a once-daily direct oral anticoagulant, was at least as effective as warfarin for preventing stroke or systemic embolism, with similar rates of major bleeding, but with a lesser risk of intracranial, critical and fatal bleedings. In the last years, different large registries have confirmed that rivaroxaban is effective and even safer in real-life patients than in ROCKET-AF. The aim of this review is to update the current evidence about the efficacy, effectiveness and safety of rivaroxaban in real-life patients.
authors.affiliation: Servicio de Cardiología, Hospital Universitario Ramón y Cajal, Madrid, España; Universidad Alcalá de Henares, Madrid, España. Electronic address: vivenciobarrios@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Barrios
authors.affiliation: Servicio de Cardiología, Hospital Universitario La Paz, Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: Escobar
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy*; D004617:Embolism / Q000209:etiology / Q000517:prevention & control; D006470:Hemorrhage / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D000069552:Rivaroxaban / Q000009:adverse effects / Q000627:therapeutic use*; D020521:Stroke / Q000209:etiology / Q000517:prevention & control; D014859:Warfarin / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D000069552:Rivaroxaban
keywords: Clinical practice; Fibrilación auricular no valvular; Nonvalvular atrial fibrillation; Pacientes de la vida real; Práctica clínica; ROCKET-AF; Real-life patients; Registro; Registry; Rivaroxaban