title: Emerging targets and new small molecule therapies in Parkinson's disease treatment.
abstract: Parkinson's disease (PD) is a common chronic degenerative disease of the central nervous system. Due to a rapidly aging society worldwide, PD morbidity is on the rise; however, the treatment of PD with conventional drugs carries serious adverse reactions and cannot fix the root cause of PD, the degeneration of dopaminergic neurons, which limits conventional drug usage in clinical practice. In recent years, research on the pathogenesis of PD and its clinical manifestations has led to the discovery of an increasing number of novel targets in PD, including several small molecule targeted compounds. In this paper, we analyze and summarize the most recently published PD literature and review several recently discovered novel targets in PD and their small molecule targeted pharmacologically active agents based on their mechanisms of action and pharmacodynamic profiles.
authors.affiliation: Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China.
authors.forename: Hongjia
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China.
authors.forename: Rongsheng
authors.initials: R
authors.lastname: Tong
authors.affiliation: Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Bai
authors.affiliation: Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China; State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China. Electronic address: shijianyoude@126.com.
authors.forename: Jianyou
authors.initials: J
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China. Electronic address: ouyangliang@scu.edu.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: Ouyang
mesh_terms: D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D054852:Small Molecule Libraries
keywords: Drug treatment; Novel targets; Parkinson’s disease; Small molecule drugs