title: Effects of radiological extent on neutrophil/lymphocyte ratio in pulmonary sarcoidosis.
abstract: OBJECTIVE
  Determining the severity of sarcoidosis is based on the clinical and radiological findings of the disease and the changes in pulmonary function test results. On the other hand; studies are ongoing for objective and easy markers in this respect. Neutrophil/lymphocyte ratio (NLR) is shown as a good prognostic marker for inflammation due to tissue damage in recent clinical trials. In this study, we aimed to identify the possible relationship between NLR and radiological extent of sarcoidosis.
  
  
  METHODS
  Data of 122 patients included in the study were evaluated retrospectively in terms of age, gender, complete blood count parameters, erythrocyte sedimentation rate (ESR) and radiological findings at the time of diagnosis.
  
  
  RESULTS
  Mean NLR and ESR were significantly different between radiological stages according to chest radiography and also total HRCT score (THS) groups according to parenchymal involvement in thorax tomography (p <0.05). Mean NLR was found to be 1.28 in stage 0, 1.65 in stage 1, 2.88 in stage 2,5.47 in stage 3 and 8.48 in stage 4; 1.63 in THS group 1, 2.01 in group 2, 3.47 in group 3 and 5.46 in group 4. There were statistically significant positive correlations between NLR and WBC, NLR and THS, NLR and ESR, THS and ESR, ESR and platelet, WBC and #neutrophil, WBC and #lymphocyte.
  
  
  CONCLUSIONS
  Our findings suggest that NLR might be used as a prognostic marker in pulmonary sarcoidosis.
authors.affiliation: Department of Intensive Care, Gulhane Military Medical Faculty, Ankara, Turkey. nesrinbaygin@yahoo.com.
authors.forename: N
authors.initials: N
authors.lastname: Ocal
authors.forename: D
authors.initials: D
authors.lastname: Dogan
authors.forename: R
authors.initials: R
authors.lastname: Ocal
authors.forename: E
authors.initials: E
authors.lastname: Tozkoparan
authors.forename: O
authors.initials: O
authors.lastname: Deniz
authors.forename: E
authors.initials: E
authors.lastname: Ucar
authors.forename: S
authors.initials: S
authors.lastname: Gumus
authors.forename: C
authors.initials: C
authors.lastname: Tasci
authors.forename: B
authors.initials: B
authors.lastname: Yildiz
authors.forename: G
authors.initials: G
authors.lastname: Taskin
authors.forename: A
authors.initials: A
authors.lastname: Taskin
authors.forename: S
authors.initials: S
authors.lastname: Badem
authors.forename: U
authors.initials: U
authors.lastname: Turhan
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001772:Blood Cell Count / Q000379:methods; D001799:Blood Sedimentation; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D011859:Radiography; D012189:Retrospective Studies; D017565:Sarcoidosis, Pulmonary / Q000097:blood* / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D015415:Biomarkers