title: Coupling pre-mRNA splicing and 3' end formation to mRNA export: alternative ways to punch the nuclear export clock.
abstract: How does a mammalian cell determine when newly synthesized mRNAs are fully processed and appropriate for nuclear export? Müller-McNicoll and colleagues (pp. 553-566) expand on mechanisms known to be mediated by nuclear export factor 1 (NXF1) by describing SR proteins as NXF1 adaptors that flag alternatively spliced and polyadenylated mRNA isoforms as cargo ready for the cytoplasm.
authors.affiliation: Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA; Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA.
authors.forename: Reyad A
authors.initials: RA
authors.lastname: Elbarbary
authors.affiliation: Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA; Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA.
authors.forename: Lynne E
authors.initials: LE
authors.lastname: Maquat
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D051379:Mice; D011485:Protein Binding; D026721:RNA 3' End Processing; D012322:RNA Precursors / Q000378:metabolism*; D012326:RNA Splicing; D034443:RNA Transport
chemical_list: D012322:RNA Precursors
keywords: NXF1; SR protein; SRSF3; SRSF7; alternative 3′ end processing; iCLIP; mRNA export