title: Potential anti-tumor effects of FTY720 associated with PP2A activation: a brief review.
abstract: FTY720 (Fingolimod, Gilenya (†) ) is an FDA-approved immunosuppressant currently used in the treatment of multiple sclerosis. However, a large number of studies over the last few years have shown that FTY720 shows potent antitumor properties that suggest its potential usefulness as a novel anticancer agent. Interestingly, the restoration of protein phosphatase 2A (PP2A) activity mediated by FTY720 could play a key role in its antitumor effects. Taking into account that PP2A inactivation is a common event that determines poor outcome in several tumor types, FTY720 could serve as an alternative therapeutic strategy for cancer patients with such alterations.
authors.affiliation: a Translational Oncology Division , Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, University Hospital 'Fundacion Jimenez Diaz' , Madrid , Spain ;
authors.forename: Ion
authors.initials: I
authors.lastname: Cristóbal
authors.affiliation: b Pathology Department , IIS 'Fundacion Jimenez Diaz' , Madrid , Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Madoz-Gúrpide
authors.affiliation: b Pathology Department , IIS 'Fundacion Jimenez Diaz' , Madrid , Spain.
authors.forename: Rebeca
authors.initials: R
authors.lastname: Manso
authors.affiliation: b Pathology Department , IIS 'Fundacion Jimenez Diaz' , Madrid , Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: González-Alonso
authors.affiliation: b Pathology Department , IIS 'Fundacion Jimenez Diaz' , Madrid , Spain.
authors.forename: Federico
authors.initials: F
authors.lastname: Rojo
authors.affiliation: a Translational Oncology Division , Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, University Hospital 'Fundacion Jimenez Diaz' , Madrid , Spain ;
authors.forename: Jesús
authors.initials: J
authors.lastname: García-Foncillas
mesh_terms: D000068876:Fingolimod Hydrochloride / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy*; D054648:Protein Phosphatase 2 / Q000187:drug effects*
chemical_list: D007166:Immunosuppressive Agents; D054648:Protein Phosphatase 2; D000068876:Fingolimod Hydrochloride
keywords: Cancer; FTY720; Fingolimod; PP2A; Therapy