title: Imbalanced cholesterol metabolism in Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease that is mainly caused by β-amyloid accumulation. A large number of studies have shown that elevated cholesterol levels may perform a function in AD pathology, and several cholesterol-related gene polymorphisms are associated with this disease. Although numerous studies have shown the important function of cholesterol in AD pathogenesis and development, the underlying mechanism remains unclear. To further elucidate cholesterol metabolism disorder and AD, we first, review metabolism and regulation of the cholesterol in the brain. Second, we summarize the literature stating that hypercholesterolemia is one of the risk factors of AD. Third, we discuss the main mechanisms of abnormal cholesterol metabolism that increase the risk of AD. Finally, the relationships between AD and apolipoprotein E, PCSK9, and LRP1 are discussed in this article.
authors.affiliation: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Xue-Shan
authors.affiliation: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Juan
authors.affiliation: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Qi
authors.affiliation: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Ren
authors.initials: R
authors.lastname: Zhong
authors.affiliation: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Li-Hong
authors.affiliation: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Tang
authors.initials: T
authors.lastname: Zhi-Han
authors.affiliation: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China. Electronic address: zsjiang2005@163.com.
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhi-Sheng
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Gui-Xue
authors.affiliation: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China; College of Bioengineering, Chongqing University, Chongqing 400030, China. Electronic address: liuls2000@163.com.
authors.forename: Liu
authors.initials: L
authors.lastname: Lu-Shan
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000378:metabolism*; D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000235:genetics; D012307:Risk Factors
chemical_list: D002784:Cholesterol
keywords: Alzheimer's disease; Aβ; Cholesterol; LRP1; PCSK9; apoE