title: Prophylactic HPV vaccination and anal cancer.
abstract: The incidence of anal cancer is increasing. High risk populations include HIV-positive men who have sex with men (MSM), HIV-negative MSM, HIV-positive women and heterosexual men and women with a history of cervical cancer. HPV has been detected in over 90% of anal cancers. HPV16 is the most common genotype detected in about 70% of anal cancers. The quadrivalent HPV (qHPV) vaccine has been demonstrated to prevent vaccine associated persistent anal HPV infections as well as anal intraepithelial neoplasia grades 2-3 (AIN2+) in young MSM not previously infected. A retrospective analysis also suggests that qHPV vaccination of older MSM treated for AIN2+ may significantly decrease the risk of recurrence of the AIN2+. The HPV types detected in anal cancer are included in the 9-valent vaccine. Thus, the 9-valent HPV vaccine, when administered to boys and girls prior to the onset of sexual activity, should effectively prevent anal cancer.
authors.affiliation: a Boston University School of Medicine , Boston , MA , USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Stier
authors.affiliation: a Boston University School of Medicine , Boston , MA , USA.
authors.forename: Nagasudha L
authors.initials: NL
authors.lastname: Chigurupati
authors.affiliation: a Boston University School of Medicine , Boston , MA , USA.
authors.forename: Leslie
authors.initials: L
authors.lastname: Fung
mesh_terms: D000293:Adolescent; D000328:Adult; D001005:Anus Neoplasms / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology; D053918:Papillomavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D016896:Treatment Outcome; D014611:Vaccination / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D053918:Papillomavirus Vaccines
keywords: HPV; HPV vaccine; anal cancer