title: Resting state functional connectivity magnetic resonance imaging integrated with intraoperative neuronavigation for functional mapping after aborted awake craniotomy.
abstract: BACKGROUND
  Awake craniotomy is currently the gold standard for aggressive tumor resections in eloquent cortex. However, a significant subset of patients is unable to tolerate this procedure, particularly the very young or old or those with psychiatric comorbidities, cardiopulmonary comorbidities, or obesity, among other conditions. In these cases, typical alternative procedures include biopsy alone or subtotal resection, both of which are associated with diminished surgical outcomes.
  
  
  METHODS
  Here, we report the successful use of a preoperatively obtained resting state functional connectivity magnetic resonance imaging (MRI) integrated with intraoperative neuronavigation software in order to perform functional cortical mapping in the setting of an aborted awake craniotomy due to loss of airway.
  
  
  CONCLUSIONS
  Resting state functional connectivity MRI integrated with intraoperative neuronavigation software can provide an alternative option for functional cortical mapping in the setting of an aborted awake craniotomy.
authors.affiliation: Department of Computer Science, Washington University, St. Louis, Missouri, USA.
authors.forename: Prag
authors.initials: P
authors.lastname: Batra
authors.affiliation: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: S Kathleen
authors.initials: SK
authors.lastname: Bandt
authors.affiliation: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA; Department of Biomedical Engineering, Washington University, St. Louis, Missouri, USA; Center for Innovation in Neuroscience and Technology, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Leuthardt
keywords: Awake craniotomy; functional mapping; intraoperative neuronavigation; resting state functional connectivity magnetic resonance imaging