title: Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL, USA astoddar@bsd.uchicago.edu.
authors.forename: Angela
authors.initials: A
authors.lastname: Stoddart
authors.affiliation: Department of Medicine, and University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Qian
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL, USA.
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Fernald
authors.affiliation: Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Rachel J
authors.initials: RJ
authors.lastname: Bergerson
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL, USA.
authors.forename: Jianghong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Public Health Sciences, University of Chicago, Chicago, IL, USA University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, USA.
authors.forename: Theodore
authors.initials: T
authors.lastname: Karrison
authors.affiliation: University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, USA Department of Pathology, University of Chicago, Chicago, IL, USA.
authors.forename: John
authors.initials: J
authors.lastname: Anastasi
authors.affiliation: Department of Biochemistry and Molecular Genetics, Northwestern University Feinburg School of Medicine, Chicago, IL, USA.
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Bartom
authors.affiliation: Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Aaron L
authors.initials: AL
authors.lastname: Sarver
authors.affiliation: University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, USA Departments of Pathology and Pediatrics, and Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.
authors.forename: Megan E
authors.initials: ME
authors.lastname: McNerney
authors.affiliation: Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Largaespada
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL, USA University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, USA.
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Le Beau
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008817:Mice, Mutant Strains; D016254:Mutagenesis, Insertional; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D010454:Peptide Termination Factors / Q000235:genetics / Q000378:metabolism; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012190:Retroviridae; D014157:Transcription Factors; D060449:Wnt Signaling Pathway / Q000235:genetics*
chemical_list: C000601091:CXXC5 protein, mouse; D004268:DNA-Binding Proteins; C489003:Etf1 protein, mouse; D047908:Intracellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; D010454:Peptide Termination Factors; D011506:Proteins; C544759:TIFAB protein, mouse; D014157:Transcription Factors
keywords: Wnt pathway; del(5q); insertional mutagenesis; myeloid neoplasms; retroviral