title: Epidemiology.
abstract: More than 250,000 new cases of primary malignant brain tumors are diagnosed annually worldwide, 77% of which are gliomas. A small proportion of gliomas are caused by the inheritance of rare high-penetrance genetic variants or high-dose radiation. Since 2009, inherited genetic variants in 10 regions near eight different genes have been consistently associated with glioma risk via genome-wide association studies. Most of these variants increase glioma risk by 20-40%, but two have higher relative risks. One on chromosome 8 increases risk of IDH-mutated gliomas sixfold and another that affects TP53 function confers a 2.5-fold increased risk of glioma. Functions of some of the other risk variants are known or suspected, but future research will determine functions of other risk loci. Recent progress also has been made in defining subgroups of glioma based on acquired alterations within tumors. Allergy history has been consistently associated with reduced glioma risk, though the mechanisms have not yet been clarified. Future studies will need to be large enough so that environmental and constitutive genetic risk factors can be examined within molecularly defined, etiologically homogeneous subgroups.
authors.affiliation: Division of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco and UCSF Helen Diller Family Cancer Center, San Francisco, CA, USA.
authors.forename: Kyle M
authors.initials: KM
authors.lastname: Walsh
authors.affiliation: Section of Molecular Pathology, International Agency for Research on Cancer, Lyon, France.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ohgaki
authors.affiliation: Division of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco and UCSF Helen Diller Family Cancer Center, San Francisco, CA, USA. Electronic address: margaret.wrensch@ucsf.edu.
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Wrensch
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D001932:Brain Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy; D006801:Humans; D009154:Mutation / Q000235:genetics; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor
keywords: allergy; environment; genetic epidemiology; genome-wide association study; glioma; prognostic marker; risk factors; survival; telomeres; tumor genetics