title: Serum pentraxin 3 as a possible marker for mature cystic teratomas.
abstract: Pentraxin 3 (PTX3) is an inflammatory mediator that is released by a wide range of tissues and cells. Elevated PTX3 levels may represent a useful diagnostic and/or prognostic marker for a number of diseases. The purpose of this study was to investigate serum PTX3 levels in benign gynecological conditions including mature cystic teratomas (MCTs), endometriomas, and uterine leiomyomas. Serum PTX3 levels of the MCT group were found to be significantly higher compared to those of the other groups, including healthy controls (p = 0.001), although carbohydrate antigen 19-9 (CA19-9) did not exhibit a significant difference. Serum PTX3 levels of the MCT, but not the endometrioma group, were also found to have significantly decreased post-operatively (mean ± standard deviation, 4.98 ± 2.10 to 3.61 ± 1.53 ng/mL). Immunohistochemical analyses demonstrated positive staining for PTX3 protein in the sebaceous glands, epidermal tissues, and hair roots of MCT specimens. PTX3 is expressed by MCTs and is associated with increased serum concentrations compared to healthy controls and patients with either endometriomas or uterine leiomyomas. We conclude that serum PTX3 levels could be used as a potential diagnostic marker for MCTs, especially helpful in differentiating them from endometriomas with elevated expression of CA19-9.
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Showa-Ku , Japan , Nagoya and.
authors.forename: Chiharu
authors.initials: C
authors.lastname: Ishida
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Showa-Ku , Japan , Nagoya and.|b Department of Maternal and Perinatal Medicine , Nagoya University Hospital , Showa-Ku , Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Iwase
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Showa-Ku , Japan , Nagoya and.
authors.forename: Satoko
authors.initials: S
authors.lastname: Osuka
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Showa-Ku , Japan , Nagoya and.
authors.forename: Maki
authors.initials: M
authors.lastname: Goto
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Showa-Ku , Japan , Nagoya and.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Takikawa
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Showa-Ku , Japan , Nagoya and.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Showa-Ku , Japan , Nagoya and.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kotani
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Showa-Ku , Japan , Nagoya and.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Kikkawa
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D004715:Endometriosis / Q000097:blood*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000097:blood* / Q000601:surgery; D008875:Middle Aged; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D013724:Teratoma / Q000097:blood* / Q000601:surgery; D014594:Uterine Neoplasms / Q000097:blood* / Q000601:surgery; D055815:Young Adult; D000099153:Pentraxins
chemical_list: D014408:Biomarkers, Tumor; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
keywords: CA19-9; endometrioma; mature cystic teratoma; pentraxin 3; tumor marker