title: Laparoscopic ovarian transposition prior to pelvic irradiation in a young female patient with advanced rectal cancer.
abstract: In the report, we describe the first case of laparoscopic ovarian transposition prior to pelvic radio-chemo therapy in a young female patient with advanced rectal cancer in Japan. A 14-year-old female visited a hospital because of consistent diarrhea and melena. Colonoscopy examination showed a bulky tumor of the rectum, which was diagnosed as moderately to poorly differentiated adenocarcinoma. The diagnosis was cT3N2aM1a (due to lymph node in pelvic side wall), cStage IVA. In an attempt to improve local control and sphincter preservation, neoadjuvant concurrent radio-chemo therapy was planned. Considering that pelvic irradiation particularly in young female might cause ovarian failure, laparoscopic ovarian transposition was carried out prior to pelvic irradiation. Sequentially the patient underwent low anterior resection of the rectum and lymphadenectomy including pelvic side wall. The menstruation was maintained with delay for 6 months after adjuvant chemotherapy. There is no evidence of cancer recurrence at 3 years after the surgery.In premenopausal patients with rectal cancer undergoing pelvic irradiation, laparoscopic ovarian transposition is one of the choices to prevent ovarian failure.
authors.affiliation: Colorectal Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. kiharaky@pref.tottori.jp.|Department of Surgery, Tottori Prefectural Central Hospital, 730 Ezu, Tottori, 680-0901, Japan. kiharaky@pref.tottori.jp.
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Kihara
authors.affiliation: Colorectal Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. miyamamo@jcom.home.ne.jp.|Department of Digestive Surgery, Hiratsuka Municipal Hospital, 1-19-1 Nambara, Hiratsuka, 254-0065, Japan. miyamamo@jcom.home.ne.jp.
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Yamamoto
authors.affiliation: Colorectal Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Oshirotai@gmail.com.|Department of Surgical Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Syouwa-ku, Nagoya, 466-8560, Japan. Oshirotai@gmail.com.
authors.forename: Taihei
authors.initials: T
authors.lastname: Ohshiro
authors.affiliation: Colorectal Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. sifujita@tcc.pref.tochigi.lg.jp.|Department of Colorectal Surgery, Tochigi Cancer Center, 9-13 Yonan 4-Chome, Utsunomiya, 320-0834, Japan. sifujita@tcc.pref.tochigi.lg.jp.
authors.forename: Shin
authors.initials: S
authors.lastname: Fujita
keywords: Fertility; Laparoscopy; Menopause; Ovarian failure; Ovarian transposition; Radiation; Rectal cancer