title: Postnatal Anthropometric and Body Composition Profiles in Infants with Intrauterine Growth Restriction Identified by Prenatal Doppler.
abstract: BACKGROUND
  Infant anthropometry and body composition have been previously assessed to gauge the impact of intrauterine growth restriction (IUGR) at birth, but the interplay between prenatal Doppler measurements and postnatal development has not been studied in this setting. The present investigation was performed to assess the significance of prenatal Doppler findings relative to postnatal anthropometrics and body composition in IUGR newborns over the first 12 months of life.
  
  
  METHODS
  Consecutive cases of singleton pregnancies with suspected IUGR were prospectively enrolled over 12 months. Fetal biometry and prenatal Doppler ultrasound examinations were performed. Body composition was assessed by absorptiometry at ages 10 days, and at 4 and 12 months.
  
  
  RESULTS
  A total of 48 pregnancies qualifying as IUGR were studied. Doppler parameters were normal in 26 pregnancies. The remaining 22 deviated from normal, marked by an Umbilical Artery Pulsatility Index (UA-PI) >95th centil or Cerebro-placental ratio (CPR) <5th centile. No significant differences emerged when comparing anthropometry and body composition at each time point, in relation to Doppler findings. Specifically, those IUGR newborns with and without abnormal Doppler findings had similar weight, length, body mass index, lean and fat mass, and bone mineral content throughout the first 12 months of life. In a separate analysis, when comparing IUGR newborns by Doppler (abnormal UA-PI vs. abnormal CPR), anthropometry and body composition did not differ significantly.
  
  
  CONCLUSIONS
  Infants with IUGR maintain a pattern of body composition during the first year of life that is independent of prenatal Doppler findings. Future studies with larger sample sizes and correlating with hormonal status are warranted to further extend the phenotypic characterization of the various conditions now classified under the common label of IUGR.
authors.affiliation: BCN-Barcelona Center of Maternal-Fetal Medicine and Neonatology (Hospital Sant Joan de Déu and Hospital Clínic), Fetal i+D Fetal Medicine Research Center, Barcelona, Spain.|Spanish Maternal and Child Health Network, Retic SAMID, Institute Carlos III, Madrid, Spain.|IDIBAPS, University of Barcelona, Barcelona, Spain.|Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Mazarico
authors.affiliation: BCN-Barcelona Center of Maternal-Fetal Medicine and Neonatology (Hospital Sant Joan de Déu and Hospital Clínic), Fetal i+D Fetal Medicine Research Center, Barcelona, Spain.|Spanish Maternal and Child Health Network, Retic SAMID, Institute Carlos III, Madrid, Spain.|IDIBAPS, University of Barcelona, Barcelona, Spain.|Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Martinez-Cumplido
authors.affiliation: Endocrinology Unit, Sant Joan de Déu University Hospital, Barcelona, Spain.|Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Díaz
authors.affiliation: Endocrinology Unit, Sant Joan de Déu University Hospital, Barcelona, Spain.|Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Sebastiani
authors.affiliation: Endocrinology Unit, Sant Joan de Déu University Hospital, Barcelona, Spain.|Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Ibáñez
authors.affiliation: BCN-Barcelona Center of Maternal-Fetal Medicine and Neonatology (Hospital Sant Joan de Déu and Hospital Clínic), Fetal i+D Fetal Medicine Research Center, Barcelona, Spain.|Spanish Maternal and Child Health Network, Retic SAMID, Institute Carlos III, Madrid, Spain.|IDIBAPS, University of Barcelona, Barcelona, Spain.|Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.
authors.forename: M D
authors.initials: MD
authors.lastname: Gómez-Roig
mesh_terms: D000886:Anthropometry; D001699:Biometry; D001823:Body Composition; D015992:Body Mass Index; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D010641:Phenotype; D011247:Pregnancy; D011446:Prospective Studies; D012737:Sex Factors; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal