title: Serum adiponectin is a negative predictor of central arterial stiffness in kidney transplant patients.
abstract: BACKGROUND
  The role of adiponectin in arterial stiffness and its relationship to cardiovascular disease is not fully demonstrated and needs further elaboration. In this study, the association between adiponectin level and arterial stiffness is studied among kidney transplant patients.
  
  
  METHODS
  Anthropometric data and biochemical data including fasting glucose, lipid profile, renal function and serum adiponectin were determined in 55 kidney transplant patients. Central arterial stiffness was measured and presented by carotid-femoral pulse wave velocity.
  
  
  RESULTS
  Univariate linear analysis showed that body weight, waist circumference, brachial pulse pressure and body mass index were correlated positively with carotid-femoral pulse wave velocity in this patient group. However, logarithmically transformed adiponectin level (log-adiponectin) correlated negatively with carotid-femoral pulse wave velocity. In multivariate regression analysis of factors significantly associated with carotid-femoral pulse wave velocity, it showed that both log-adiponectin (β = -0.427; R(2) = 0.205, p = 0.001) and body weight (β = 0.327; R(2 )=( )0.106, p = 0.007) were independently predictive of central arterial stiffness.
  
  
  CONCLUSIONS
  Our study suggests that fasting serum adiponectin is negatively associated with carotid-femoral pulse wave velocity, hence arterial stiffness, in kidney transplant patients.
authors.affiliation: a Department of Surgery , Buddhist Tzu Chi General Hospital , Hualien , Taiwan ;
authors.forename: Ching-Chun
authors.initials: CC
authors.lastname: Ho
authors.affiliation: b Division of Nephrology , Buddhist Tzu Chi General Hospital , Hualien , Taiwan ;|c School of Medicine , Tzu Chi University , Hualien , Taiwan ;
authors.forename: Bang-Gee
authors.initials: BG
authors.lastname: Hsu
authors.affiliation: c School of Medicine , Tzu Chi University , Hualien , Taiwan ;|d Department of Organ Transplantation Surgery , Buddhist Dalin Tzu Chi General Hospital , Chia-Yi , Taiwan.
authors.forename: Wen-Yao
authors.initials: WY
authors.lastname: Yin
authors.affiliation: a Department of Surgery , Buddhist Tzu Chi General Hospital , Hualien , Taiwan ;|c School of Medicine , Tzu Chi University , Hualien , Taiwan ;
authors.forename: Guan-Jin
authors.initials: GJ
authors.lastname: Ho
authors.affiliation: a Department of Surgery , Buddhist Tzu Chi General Hospital , Hualien , Taiwan ;|c School of Medicine , Tzu Chi University , Hualien , Taiwan ;
authors.forename: Yen-Cheng
authors.initials: YC
authors.lastname: Chen
authors.affiliation: a Department of Surgery , Buddhist Tzu Chi General Hospital , Hualien , Taiwan ;|c School of Medicine , Tzu Chi University , Hualien , Taiwan ;
authors.forename: Ming-Che
authors.initials: MC
authors.lastname: Lee
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000473:pathology; D007674:Kidney Diseases / Q000097:blood / Q000473:pathology / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D065840:Protective Factors; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin
keywords: Adiponectin; arterial stiffness; body weight; kidney transplantation; pulse wave analysis