title: Preterm Birth and Hypertension: Is There a Link?
abstract: Factors in perinatal life have recently been recognized as determinants of later life health and diseases, especially hypertension. The detection of higher values of blood pressure in preterm-born individuals reaching adulthood has turned the attention to preterm birth-related complications and deleterious conditions as factors triggering early cardiovascular alterations, which may increase hypertension risk and associated complications in this population. Further, preterm birth is frequently associated with pregnancy complications such as lower placental perfusion, increased blood pressure in the mother and preeclampsia, often resulting in intrauterine growth restriction. These conditions further impact the risk of hypertension in the offspring whether through inherited genetic factors or perpetuated pathophysiology leading to preeclampsia, preterm delivery, and chronic hypertension. In this review, we will highlight evidence of developmental cardiovascular alterations and potential mechanisms linking preterm birth to the risk of hypertension and cardiovascular diseases into adulthood.
authors.affiliation: Department of Pediatrics, Sainte-Justine University Hospital Research Center, Université de Montréal, 3175 Chemin de la Côte-Sainte-Catherine, Montréal, Québec, H3T 1C5, Canada. mariane.b@gmail.com.
authors.forename: Mariane
authors.initials: M
authors.lastname: Bertagnolli
authors.affiliation: Department of Pediatrics, Sainte-Justine University Hospital Research Center, Université de Montréal, 3175 Chemin de la Côte-Sainte-Catherine, Montréal, Québec, H3T 1C5, Canada. thuy.mai.luu@umontreal.ca.
authors.forename: Thuy Mai
authors.initials: TM
authors.lastname: Luu
authors.affiliation: Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK. adam.lewandowski@cardiov.ox.ac.uk.
authors.forename: Adam James
authors.initials: AJ
authors.lastname: Lewandowski
authors.affiliation: Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK. paul.leeson@cardiov.ox.ac.uk.
authors.forename: Paul
authors.initials: P
authors.lastname: Leeson
authors.affiliation: Department of Pediatrics, Sainte-Justine University Hospital Research Center, Université de Montréal, 3175 Chemin de la Côte-Sainte-Catherine, Montréal, Québec, H3T 1C5, Canada. anne-monique.nuyt@recherche-ste-justine.qc.ca.|Division of Neonatology, Department of Pediatrics, Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, H3T 1C5, Montréal, Québec, Canada. anne-monique.nuyt@recherche-ste-justine.qc.ca.
authors.forename: Anne Monique
authors.initials: AM
authors.lastname: Nuyt
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000503:physiopathology; D007231:Infant, Newborn; D018919:Neovascularization, Physiologic; D011247:Pregnancy; D047928:Premature Birth / Q000209:etiology*
keywords: Cardiac development; Developmental origins of cardiovascular diseases; Hypertension; Preeclampsia; Premature infant; Preterm birth