title: Behavioral Periodicity Detection from 24 h Wrist Accelerometry and Associations with Cardiometabolic Risk and Health-Related Quality of Life.
abstract: Periodicities (repeating patterns) are observed in many human behaviors. Their strength may capture untapped patterns that incorporate sleep, sedentary, and active behaviors into a single metric indicative of better health. We present a framework to detect periodicities from longitudinal wrist-worn accelerometry data. GENEActiv accelerometer data were collected from 20 participants (17 men, 3 women, aged 35-65) continuously for 64.4 ± 26.2 (range: 13.9 to 102.0) consecutive days. Cardiometabolic risk biomarkers and health-related quality of life metrics were assessed at baseline. Periodograms were constructed to determine patterns emergent from the accelerometer data. Periodicity strength was calculated using circular autocorrelations for time-lagged windows. The most notable periodicity was at 24 h, indicating a circadian rest-activity cycle; however, its strength varied significantly across participants. Periodicity strength was most consistently associated with LDL-cholesterol (r's = 0.40-0.79, P's < 0.05) and triglycerides (r's = 0.68-0.86, P's < 0.05) but also associated with hs-CRP and health-related quality of life, even after adjusting for demographics and self-rated physical activity and insomnia symptoms. Our framework demonstrates a new method for characterizing behavior patterns longitudinally which captures relationships between 24 h accelerometry data and health outcomes.
authors.affiliation: Arizona State University, Phoenix, AZ 85004, USA.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Buman
authors.affiliation: Dublin City University, Dublin, Ireland.
authors.forename: Feiyan
authors.initials: F
authors.lastname: Hu
authors.affiliation: Dublin City University, Dublin, Ireland.
authors.forename: Eamonn
authors.initials: E
authors.lastname: Newman
authors.affiliation: Dublin City University, Dublin, Ireland.
authors.forename: Alan F
authors.initials: AF
authors.lastname: Smeaton
authors.affiliation: Phoenix Veterans Affairs Health Care System, Phoenix, AZ 85012, USA.
authors.forename: Dana R
authors.initials: DR
authors.lastname: Epstein
mesh_terms: D061725:Accelerometry; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000503:physiopathology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D011788:Quality of Life; D012307:Risk Factors; D057185:Sedentary Behavior; D014280:Triglycerides / Q000097:blood; D014953:Wrist / Q000503:physiopathology
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides