title: Enantioconvergent Fukuyama Cross-Coupling of Racemic Benzylic Organozinc Reagents.
abstract: The first enantioconvergent palladium-catalyzed Fukuyama cross-coupling of racemic benzylic organozinc reagents with thioesters has been developed. The reaction furnishes enantioenriched acyclic α-disubstituted ketone products in good yields and high enantioselectivities. A broad substrate scope is achieved under mild reaction conditions to prevent racemization of the potentially labile tertiary stereocenters.
authors.affiliation: University of Vienna, Faculty of Chemistry, Institute of Organic Chemistry, Währinger Strasse 38, 1090, Vienna, Austria.
authors.forename: Rik
authors.initials: R
authors.lastname: Oost
authors.affiliation: University of Vienna, Faculty of Chemistry, Institute of Organic Chemistry, Währinger Strasse 38, 1090, Vienna, Austria.
authors.forename: Antonio
authors.initials: A
authors.lastname: Misale
authors.affiliation: University of Vienna, Faculty of Chemistry, Institute of Organic Chemistry, Währinger Strasse 38, 1090, Vienna, Austria. nuno.maulide@univie.ac.at.
authors.forename: Nuno
authors.initials: N
authors.lastname: Maulide
keywords: cross-coupling; enantioselectivity; ligand effects; palladium; zinc