title: The Experimental Research (In Vitro) of Carrageenans and Fucoidans to Decrease Activity of Hantavirus.
abstract: The effect of carrageenans and fucoidans on the activity of Hantavirus is studied. It has been found that among carrageenans a significant antiviral effect is exerted by the ι-type, which decreases the viral titer by 2.5 log focus forming units per mL; among fucoidans, by a preparation from Laminaria cichorioides, which reduces the number of infected cells from 27.0 to 5.3 after pretreatment of both the macrophage culture and Hantavirus. The antiviral effect of fucoidan from Laminaria japonica is shown to grow in direct proportion to the increase of dose of the preparation.
authors.affiliation: School of Natural Sciences, Far Eastern Federal University (FEFU), Vladivostok, Russia.
authors.forename: Stanislav N
authors.initials: SN
authors.lastname: Pavliga
authors.affiliation: Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
authors.forename: Galina G
authors.initials: GG
authors.lastname: Kompanets
authors.affiliation: School of Natural Sciences, Far Eastern Federal University (FEFU), Vladivostok, Russia. tsig_90@mail.ru.|School of Biomedicine, Far Eastern Federal University (FEFU), 8 Sukhanova str., 690000, Vladivostok, Russia. tsig_90@mail.ru.
authors.forename: Vasiliy Yu
authors.identifier: 0000-0002-5095-7260
authors.initials: VY
authors.lastname: Tsygankov
mesh_terms: D002351:Carrageenan / Q000302:isolation & purification / Q000494:pharmacology*; D006476:Orthohantavirus / Q000187:drug effects* / Q000502:physiology; D007795:Laminaria / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D012624:Seaweed / Q000737:chemistry
chemical_list: D010936:Plant Extracts; D011134:Polysaccharides; D002351:Carrageenan; C007789:fucoidan
keywords: Carrageenans; Fucoidans; Hantaan virus; In vitro