title: Graft survival rate of renal transplantation during a period of 10 years in Iran.
abstract: BACKGROUND
  Kidney transplantation is a preferred treatment for many patients with end-stage renal disease (ESRD) and is far more profitable than hemodialysis. Analyzing renal transplantation data can help to evaluate the effectiveness of transplantation interventions. The aim of this study was to determine the organ survival rate after kidney transplantation during a period of 10 years (March 2001-March 2011) among transplanted patients in Arak, Markazi Province, Iran.
  
  
  METHODS
  In this historical cohort study, all recipients of kidney transplantation from Arak, Markazi Province, Iran who had medical records in Valiasr Hospital and "charity for kidney patients" of Arak, Markazi Province, Iran during a period of 10 years from March 2001 to March 2011 were included. Data collected by using checklists were completed from patients' hospital records. Kaplan-Meier method was used to determine the graft cumulative survival rate, log-rank test to compare survival curves in subgroups, and Cox regression model to define the hazard ratio and for ruling out the intervening factors. Statistical analysis was conducted by Statistical Package for the Social Sciences (SPSS) 20 and Stata 11.
  
  
  RESULTS
  Mean duration of follow-up was 55.43 ± 42.02 months. By using the Kaplan-Meier method, the cumulative probability of graft survival at 1, 3, 5, 7, and 10 years was 99.1, 97.7, 94.3, 85.7, and 62.1%, respectively. The number of dialysis by controlling the effect of other variables had a significant association with the risk of graft failure [hazard ratios and 95% confidence interval (CI): 1.47 (1.02-2.13)].
  
  
  CONCLUSIONS
  This study showed that the graft survival rate was satisfactory in this community and was similar to the results of single-center studies in the world. Dialysis time after transplantation was a significant predictor of survival in the recipients of kidney transplantation that should be considered.
authors.affiliation: Department of Public Health, Student Research Committee, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Shahbazi
authors.affiliation: Department of Epidemiology, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ranjbaran
authors.affiliation: Department of Public Health, Student Research Committee, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Simin
authors.initials: S
authors.lastname: Karami-Far
authors.affiliation: Department of Epidemiology, Safety Promotion and Injury Prevention Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Soori
authors.affiliation: Department of Nursing, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Hadi Jafari
authors.initials: HJ
authors.lastname: Manesh
keywords: Graft rejection; Iran; kidney transplantation; survival analysis