title: Effect of hypovolemia on traumatic spinal cord injury.
abstract: OBJECTIVE
  Experimentally evaluate the effect of hypovolemia in acute traumatic spinal cord injury.
  
  
  METHODS
  Twenty adult male Wistar rats were submitted to traumatic spinal cord injury through spinal cord contusion by direct impact. Ten animals were subjected to bleeding of 20% of their estimated blood to simulate a hypovolemic condition after spinal cord contusion and 10 animals were used as control. The animals were evaluated before, 1, 3, 7 and 14 days after the production of the spinal cord injury through behavioral tests (inclined plane test and motor assessment).
  
  
  RESULTS
  The spinal cord contusion associated with hypovolemia had a negative influence on functional outcomes of the spinal cord injury. The animals submitted to hypovolemia after spinal cord contusion had lower scores in behavioral tests (inclined plane test and motor assessment), presenting a slower recovery of the motor function.
  
  
  CONCLUSIONS
  In the experimental model used, the group of animals with hypovolemia after traumatic spinal cord injury had slower recovery and lower intensity in behavioral tests.
authors.affiliation: Graduate School of Health and Science, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: O
authors.initials: O
authors.lastname: de Cassia Sampaio
authors.affiliation: Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: H L A
authors.initials: HL
authors.lastname: Defino
authors.affiliation: Department of Morphology, Basic Physiology and Pathology, Ribeirão Preto Dental School, University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: E A
authors.initials: EA
authors.lastname: Del Bel Belluz Guimarães
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D020896:Hypovolemia / Q000209:etiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013119:Spinal Cord Injuries / Q000150:complications*; D018709:Statistics, Nonparametric; D013997:Time Factors