title: Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease.
abstract: Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.
authors.affiliation: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy; PhD in Nutritional Sciences University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy. Electronic address: evelyn.ferri@unimi.it.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Ferri
authors.affiliation: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy; Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Arosio
authors.affiliation: Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy; European Center for Brain Research (CERC)/Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: D'Addario
authors.affiliation: Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Via Francesco Sforza 35, 20122 Milan, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Galimberti
authors.affiliation: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Gussago
authors.affiliation: Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Pucci
authors.affiliation: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy; PhD in Nutritional Sciences University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Casati
authors.affiliation: Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Via Francesco Sforza 35, 20122 Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Fenoglio
authors.affiliation: Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Abbate
authors.affiliation: Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.
authors.forename: Paolo Dionigi
authors.initials: PD
authors.lastname: Rossi
authors.affiliation: Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Via Francesco Sforza 35, 20122 Milan, Italy.
authors.forename: Elio
authors.initials: E
authors.lastname: Scarpini
authors.affiliation: European Center for Brain Research (CERC)/Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy; Campus Bio-Medico University of Rome, Via Álvaro del Portillo 21, 00128 Rome, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Maccarrone
authors.affiliation: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy; Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Mari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D019175:DNA Methylation / Q000235:genetics*; D005260:Female; D057180:Frontotemporal Dementia / Q000175:diagnosis / Q000235:genetics*; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D000072340:NIMA-Interacting Peptidylprolyl Isomerase / Q000235:genetics* / Q000378:metabolism; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D012333:RNA, Messenger; D016875:tau Proteins; C000606846:PIN1 protein, human
keywords: Alzheimer's disease; Frontotemporal dementia; Methylation; Neurodegeneration; Peripheral marker; Pin1