title: Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases.
abstract: Autophagy is a cell survival process which is related to breaking down and reusing cytoplasm components. Moreover, autophagy regulates cell death under certain conditions. Apoptosis has the characteristics of chromatin agglutination and the shrinking of nuclear and apoptosis body form. Even if the mechanisms of autophagy and apoptosis have differences, some proteins modulate both autophagy and apoptosis. Crosstalk between them exists. This review highlights recent advances in the interaction of autophagy and apoptosis and its importance in the development of cardiovascular diseases.
authors.affiliation: Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. zhongyilimeng@163.com.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Medical Imaging, Urumqi General Hospital of Lanzhou Military Area Command, Urumqi 830000, China. doctorgaoping@sina.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Gao
authors.affiliation: Department of cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medcine, Tianjin 300192, China. tjzhtcm@163.com.
authors.forename: Junping
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001343:Autophagy / Q000187:drug effects; D000071183:Autophagy-Related Proteins / Q000378:metabolism; D000071186:Beclin-1 / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D002319:Cardiovascular System / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D020169:Caspases / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D000071183:Autophagy-Related Proteins; D000071186:Beclin-1; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D020169:Caspases
keywords: apoptosis; autophagy; cardiovascular diseases; crosstalk