title: The excretion and environmental effects of amoxicillin, ciprofloxacin, and doxycycline residues in layer chicken manure.
abstract: The excretion rates and ecological risk to the environment of three commonly used veterinary antibiotics (VAs), amoxicillin, ciprofloxacin, and doxycycline, in layer hen manure during the application and withdrawal periods were investigated in a study consisting of a control group fed with VA-free basal diet and nine treatment groups consisted of three levels (200 mg/kg, 100 mg/kg, and 50 mg/kg) of amoxicillin (AMX), ciprofloxacin (CIP), or doxycycline (DOC). Each treatment group was replicated seven times with three layer hens per replication. Results of the study showed that the average excretion rates of AMX in the 200, 100, and 50 mg/kg groups were 67.88, 55.82, and 66.15%, respectively, while those for CIP and DOC were 47.84, 51.85, and 44.87% and 82.67, 94.39, and 95.72%, respectively. The concentrations of the above veterinary drugs in manure decreased sharply in the withdrawal period (7, 28, and 10 d, respectively), for AMX, DOC, and CIP. Neither AMX nor DOC was detected in the manure after the withdrawal period. In contrast to AMX and DOC, the excretion rate of CIP was significantly lower and thus had a longer residence time. Ecological risk study, estimated using hazard quotient values, showed that AMX in the 100 and 50 mg/kg groups posed no risk to the environment after d 1 of withdrawal, while CIP in the 50 mg/kg group posed no risk to the environment from d 5 of withdrawal. CIP in the 200 and 100 mg/kg groups required 10 d withdrawal in order to pose no risk to the environment. In contrast, DOC residue during withdrawal in the manure posed no risk to the environment, thus making it more environmentally safe.
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou 510642, People's Republic of China Ministry of Agriculture Key Laboratory of Tropical Agricultural Environment, South China Agricultural University, Guangzhou 510642, People's Republic of China.
authors.forename: Ping-cai
authors.initials: PC
authors.lastname: Peng
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou 510642, People's Republic of China Ministry of Agriculture Key Laboratory of Tropical Agricultural Environment, South China Agricultural University, Guangzhou 510642, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou 510642, People's Republic of China Ministry of Agriculture Key Laboratory of Tropical Agricultural Environment, South China Agricultural University, Guangzhou 510642, People's Republic of China.
authors.forename: Long-yong
authors.initials: LY
authors.lastname: Liu
authors.affiliation: Nanhai Entry-Exit Inspection and Quarantine Bureau, Foshan 528200, China.
authors.forename: Yong-de
authors.initials: YD
authors.lastname: Zou
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou 510642, People's Republic of China Ministry of Agriculture Key Laboratory of Tropical Agricultural Environment, South China Agricultural University, Guangzhou 510642, People's Republic of China.
authors.forename: Xin-di
authors.initials: XD
authors.lastname: Liao
authors.affiliation: Institute of Tropical Agriculture, Universiti Putra Malaysia, 43400 Serdang, Malaysia.
authors.forename: Juan-boo
authors.initials: JB
authors.lastname: Liang
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou 510642, People's Republic of China Ministry of Agriculture Key Laboratory of Tropical Agricultural Environment, South China Agricultural University, Guangzhou 510642, People's Republic of China Guangdong Engineering Research Center for Modern Eco-agriculture and Circular Agriculture, Guangzhou 510642, China wuyinbao@scau.edu.cn.
authors.forename: Yin-bao
authors.initials: YB
authors.lastname: Wu
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism; D002645:Chickens; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D005243:Feces / Q000737:chemistry*; D005260:Female; D010058:Oviposition; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D000658:Amoxicillin; D004318:Doxycycline
keywords: amoxicillin; ciprofloxacin; doxycycline; environment risk; excretion