title: Asians compared to Whites show increased response to d-amphetamine on select subjective and cardiovascular measures.
abstract: OBJECTIVE
  Identifying factors that moderate subjective response to stimulants is important for understanding individuals at risk for abusing these drugs. Some research suggests that Asians may respond differently to stimulants than other races, but controlled human laboratory research of stimulant administration effects in Asians is scant.
  
  
  METHODS
  In this double-blind counterbalanced within-subject study, healthy stimulant-naïve participants (N = 65; 55% Asian; 63% female; age 18-35) received a single dose of 20-mg oral d-amphetamine or placebo on separate days. At each testing day, subjective measures of abuse liability and cardiovascular assessments were administered at repeated intervals before and after drug administration over a 4-hour period.
  
  
  RESULTS
  Asians (vs. Whites) demonstrated greater d-amphetamine-induced increases in diastolic blood pressure and ratings of 'Feel High' and 'Like Drug'.
  
  
  CONCLUSIONS
  Asian and White healthy young adults may differ in certain subjective and cardiovascular responses to acute doses of d-amphetamine. Such individual differences could help explain between-person differences in abuse potential of d-amphetamine and other stimulants.
authors.affiliation: Department of Preventive Medicine, University of Southern California. Electronic address: rpang@usc.edu.
authors.forename: Raina D
authors.initials: RD
authors.lastname: Pang
authors.affiliation: Department of Preventive Medicine, University of Southern California.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Kirkpatrick
authors.affiliation: Department of Preventive Medicine, University of Southern California.
authors.forename: Nicholas I
authors.initials: NI
authors.lastname: Goldenson
authors.affiliation: Department of Preventive Medicine, University of Southern California.
authors.forename: Casey R
authors.initials: CR
authors.lastname: Guillot
authors.affiliation: Department of Preventive Medicine, University of Southern California; Department of Psychology, University of Southern California.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Leventhal
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D044465:White People; D055815:Young Adult
chemical_list: D010919:Placebos; D003913:Dextroamphetamine
keywords: Asian; d-amphetamine; drug response; race