title: DNA methylation dynamics in neurogenesis.
abstract: Neurogenesis is not limited to the embryonic stage, but continually proceeds in the adult brain throughout life. Epigenetic mechanisms, including DNA methylation, histone modification and noncoding RNA, play important roles in neurogenesis. For decades, DNA methylation was thought to be a stable modification, except for demethylation in the early embryo. In recent years, DNA methylation has proved to be dynamic during development. In this review, we summarize the latest understanding about DNA methylation dynamics in neurogenesis, including the roles of different methylation forms (5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine), as well as their 'writers', 'readers' and interactions with histone modifications.
authors.affiliation: Department of Human Genetics, Emory University, Atlanta, GA 30322, USA.|Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
authors.forename: Beisha
authors.initials: B
authors.lastname: Tang
authors.affiliation: Department of Cardiology, The Third Affiliated Hospital of Jilin University, Jilin University, Changchun, Jilin, PR China.
authors.forename: Yuquan
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Human Genetics, Emory University, Atlanta, GA 30322, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Jin
mesh_terms: D044503:5-Methylcytosine / Q000378:metabolism / Q000031:analogs & derivatives; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D003596:Cytosine / Q000031:analogs & derivatives / Q000378:metabolism; D019175:DNA Methylation; D004622:Embryo, Mammalian / Q000502:physiology; D053595:Embryonic Stem Cells / Q000502:physiology; D044127:Epigenesis, Genetic; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000235:genetics; D055495:Neurogenesis / Q000235:genetics*
chemical_list: C560974:5-carboxylcytosine; C560973:5-formylcytosine; D006657:Histones; C011865:5-hydroxymethylcytosine; D044503:5-Methylcytosine; D003596:Cytosine
keywords: DNA methylation; DNA methyltransferase; TET family protein; histone modification; neurogenesis