title: B7-H4 is a positive regulator of antitumor immunity.
abstract: B7-H4 (B7x, B7S1, VTCN1, DD-0110) is a member of the B7 superfamily that negatively regulates T cell responses.1In addition, B7-H4 expression is increased on tumors and has been shown to be a negative prognostic marker for many cancers.2Unexpectedly our recent study demonstrated that B7-H4 inhibited tumor growth and was required to promote effective antitumor responses.3.
authors.affiliation: Campbell Family Institute for Breast Cancer Research; Princess Margaret Cancer Centre; Toronto, Ontario, Canada; Department of Immunology.
authors.forename: Ramtin
authors.initials: R
authors.lastname: Rahbar
authors.affiliation: Campbell Family Institute for Breast Cancer Research; Princess Margaret Cancer Centre; Toronto, Ontario, Canada; Department of Immunology; Department of Medical Biophysics; University of Toronto; Toronto, Ontario, Canada.
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Ohashi
keywords: B7-H4; T lymphocytes; cancer; co-inhibitory molecules