title: An Intestinal Inflammasome - The ILC3-Cytokine Tango.
abstract: The inflammasome is a key regulator of immune responses in the gut. Two recent studies in the journal Cell demonstrate that epithelial inflammasome activation and IL-18 secretion can control intestinal homeostasis or induce autoinflammation. ILC3 cells are triggered to secrete IL-22, regulating IL-18 expression in epithelial cells, in turn modulating homeostasis and inflammation.
authors.affiliation: Innate Immunity Unit, Institut Pasteur, Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U1223, Paris, France. Electronic address: pedro.goncalves@pasteur.fr.
authors.forename: Pedro
authors.initials: P
authors.lastname: Gonçalves
authors.affiliation: Innate Immunity Unit, Institut Pasteur, Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U1223, Paris, France.
authors.forename: James P
authors.initials: JP
authors.lastname: Di Santo
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000187:drug effects*; D003092:Colitis / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000473:pathology* / Q000503:physiopathology*; D003106:Colon / Q000187:drug effects* / Q000276:immunology* / Q000382:microbiology*; D004043:Dietary Fiber / Q000494:pharmacology*; D005232:Fatty Acids, Volatile / Q000378:metabolism*; D005260:Female; D058847:Inflammasomes / Q000187:drug effects* / Q000276:immunology*; D020382:Interleukin-18 / Q000276:immunology*; D008297:Male; D064307:Microbiota; D011956:Receptors, Cell Surface / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D002352:Carrier Proteins; D004043:Dietary Fiber; D005232:Fatty Acids, Volatile; D058847:Inflammasomes; D020382:Interleukin-18; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D011978:Receptors, Nicotinic
keywords: IL-18; IL-22; inflammasome; innate lymphoid cells; metabolites; microbiota