title: Interleukin-6 Receptor Polymorphisms Contribute to the Neurological Status of Korean Patients with Ischemic Stroke.
abstract: To investigate the contribution of the interleukin-6 receptor (IL-6R) gene single nucleotide polymorphisms (SNPs) to the neurological status of Korean patients with ischemic stroke (IS), two SNPs of the IL-6R gene (rs4845617, 5 UTR; rs2228144, Ala31Ala) were selected. IS patients were classified into clinical phenotypes according to two well-defined scores: the National Institutes of Health Stroke Survey (NIHSS) and the Modified Barthel Index scores. There were 121 IS patients and 291 control subjects. The SNP rs4845617 significantly contributed to the neurological status of patients with IS (P = 0.011 in codominant model 2, P = 0.006 in recessive model, and P = 0.008 in log-additive model). Allele frequencies of rs4845617 and rs2228144 demonstrated no significant difference in IS patients and controls. The AG and GG haplotypes differed between the NIHSS 1 (NIHSS scores < 6) group and the NIHSS 2 (NIHSS scores ≥ 6) group in patients with IS (P = 0.014, P = 0.0024). These results suggest that rs4845617 of the IL-6R gene is associated with the neurologic status of Korean patients with IS.
authors.affiliation: Department of Physical Medicine & Rehabilitation, College of Medicine, Kyung Hee University, Seoul, Korea .
authors.forename: Dong Hwan
authors.identifier: 0000-0002-3812-5509
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Physical Medicine & Rehabilitation, College of Medicine, Kyung Hee University, Seoul, Korea .
authors.forename: Seung Don
authors.initials: SD
authors.lastname: Yoo
authors.affiliation: Department of Physical Medicine & Rehabilitation, College of Medicine, Kyung Hee University, Seoul, Korea .
authors.forename: Jinmann
authors.initials: J
authors.lastname: Chon
authors.affiliation: Department of Physical Medicine & Rehabilitation, College of Medicine, Kyung Hee University, Seoul, Korea .
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Yun
authors.affiliation: Department of Physical Medicine & Rehabilitation, College of Medicine, Kyung Hee University, Seoul, Korea .
authors.forename: Hee-Sang
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Kohwang Medical Research Institute, Kyung Hee University, Seoul, Korea .
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Kohwang Medical Research Institute, Kyung Hee University, Seoul, Korea .
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Kohwang Medical Research Institute, Kyung Hee University, Seoul, Korea .
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Department of Physical Medicine & Rehabilitation, College of Medicine, Kyung Hee University, Seoul, Korea .
authors.forename: Jin Kyu
authors.initials: JK
authors.lastname: Kang
authors.affiliation: Department of Physical Medicine & Rehabilitation, College of Medicine, Kyung Hee University, Seoul, Korea .
authors.forename: Seung Ah
authors.identifier: 0000-0002-3426-6259
authors.initials: SA
authors.lastname: Lee
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D019947:Receptors, Interleukin-6 / Q000235:genetics*; D056910:Republic of Korea; D012720:Severity of Illness Index; D020521:Stroke / Q000235:genetics* / Q000473:pathology
chemical_list: D019947:Receptors, Interleukin-6
keywords: Brain Ischemia; Interleukin 6-Interleukin 6 Receptor Fusion Protein, Recombinant; Neurological Manifestations; Polymorphism; Stroke