title: Telomere length change plateaus at 4 years of age in Latino children: associations with baseline length and maternal change.
abstract: Telomeres are the protective complexes at the end of chromosomes, required for genomic stability. Little is known about predictors of attrition in young children or the relationship between parental and child patterns of telomere change. Telomere length was assessed twice over one year, at 4 and at 5 years of age, in Latino preschool children (n = 77) and their mothers (n = 70) in whole blood leukocytes. Maternal and child rates of attrition during the same time period were compared in 70 mother-child pairs. More children showed lengthened telomeres over one year compared to their mothers and very few children showed attrition (2.6 %). Approximately 31 % of children and 16 % of mothers displayed lengthening over one year while 66 % of children showed maintenance in contrast with 74 % of mothers. The strongest predictor for child telomere length change was child's baseline telomere length (r = -0.61, p < 0.01). Maternal rate of change was associated with child rate of change (r = 0.33, p < 0.01). After controlling for child baseline telomere length, the relationship between child and maternal rate of change trended towards significance (Coeff = 0.20, 95 % CI -0.03 to 0.43; p = 0.08). We found primarily maintenance and lengthening from 4 to 5 years of age in children, with minimal telomere attrition, indicating that most of the telomere loss happens in the first 4 years, plateauing by age 4. Lastly, we found close to 10 % of the variance in rate of change in children shared by mothers. While some of this shared variance is genetic, there are likely environmental factors that need to be further identified that impact rate of telomere length change.
authors.affiliation: Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. Wojcicki@gmail.com.
authors.forename: Janet M
authors.initials: JM
authors.lastname: Wojcicki
authors.affiliation: Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Shiboski
authors.affiliation: Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Melvin B
authors.initials: MB
authors.lastname: Heyman
authors.affiliation: Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Deena
authors.initials: D
authors.lastname: Elwan
authors.affiliation: Department of Biophysics and Biochemistry, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Jue
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Biophysics and Biochemistry, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Blackburn
authors.affiliation: Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Elissa
authors.initials: E
authors.lastname: Epel
mesh_terms: D000328:Adult; D002675:Child, Preschool; D005260:Female; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008297:Male; D009034:Mother-Child Relations; D016615:Telomere / Q000378:metabolism*; D059505:Telomere Homeostasis
keywords: Attrition rate; Heritability; Latinos; Telomere