title: [(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography.
abstract: Here we report the radiosynthesis of an endogenous redox pair, [(11)C]ascorbic acid ([(11)C]VitC) and [(11)C]dehydroascorbic acid ([(11)C]DHA), the reduced and oxidized forms of vitamin C, and their application to ROS sensing. These results provide the basis for in vivo detection of ROS using positron emission tomography (PET).
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94107, USA. David.M.Wilson@ucsf.edu.
authors.forename: V N
authors.initials: VN
authors.lastname: Carroll
authors.forename: C
authors.initials: C
authors.lastname: Truillet
authors.forename: B
authors.initials: B
authors.lastname: Shen
authors.forename: R R
authors.initials: RR
authors.lastname: Flavell
authors.forename: X
authors.initials: X
authors.lastname: Shao
authors.forename: M J
authors.initials: MJ
authors.lastname: Evans
authors.forename: H F
authors.initials: HF
authors.lastname: VanBrocklin
authors.forename: P J H
authors.initials: PJ
authors.lastname: Scott
authors.forename: F T
authors.initials: FT
authors.lastname: Chin
authors.forename: D M
authors.initials: DM
authors.lastname: Wilson
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry*; D002250:Carbon Radioisotopes / Q000737:chemistry*; D010084:Oxidation-Reduction; D049268:Positron-Emission Tomography; D017382:Reactive Oxygen Species / Q000032:analysis*
chemical_list: D002250:Carbon Radioisotopes; D017382:Reactive Oxygen Species; D001205:Ascorbic Acid