title: Matrix-Assisted Ionization on a Portable Mass Spectrometer: Analysis Directly from Biological and Synthetic Materials.
abstract: Matrix-assisted ionization (MAI)-mass spectrometry (MS) eliminates the need for high voltage, a heat source, lasers, and compressed gases in the ionization process and uses minimal solvents in sample preparation, thus making MAI ideal for field-portable mass spectrometers. The broad applicability of MAI is demonstrated by simple, rapid, and robust positive and negative detection mode analyses of low and high mass compounds including some pesticides, dyes, drugs, lipids, and proteins (186 Da to 8.5 kDa) from various materials including urine, biological tissue sections, paper, and plant material on a low pumping capacity, single-quadrupole mass spectrometer. Different sample introduction methods are applicable, including the use of a pipet tip or glass melting point tube, allowing integration of sample preparation with sample introduction for increased analytical utility and ease of operation, even when sampling directly from surfaces.
authors.affiliation: Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States.
authors.forename: Zachary J
authors.initials: ZJ
authors.lastname: Devereaux
authors.affiliation: Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Reynolds
authors.affiliation: Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States.
authors.forename: Joshua L
authors.initials: JL
authors.lastname: Fischer
authors.affiliation: Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States.
authors.forename: Casey D
authors.initials: CD
authors.lastname: Foley
authors.affiliation: Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: DeLeeuw
authors.affiliation: Gill Center for Biomolecular Science, Indiana University , 702 N. Walnut Grove Avenue, Bloomington, Indiana 47405, United States.
authors.forename: James
authors.initials: J
authors.lastname: Wager-Miller
authors.affiliation: Detroit Medical Center: Detroit Hospital, 4201 St. Antoine Street, Detroit, Michigan 48201, United States.
authors.forename: Srinivas B
authors.initials: SB
authors.lastname: Narayan
authors.affiliation: Gill Center for Biomolecular Science, Indiana University , 702 N. Walnut Grove Avenue, Bloomington, Indiana 47405, United States.
authors.forename: Ken
authors.initials: K
authors.lastname: Mackie
authors.affiliation: Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States.|Cardiovascular Research Institute, Wayne State University School of Medicine , 421 E. Canfield Street, Detroit, Michigan 48202, United States.
authors.forename: Sarah
authors.initials: S
authors.lastname: Trimpin
mesh_terms: D004396:Coloring Agents / Q000032:analysis*; D008055:Lipids / Q000032:analysis*; D010575:Pesticides / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011506:Proteins / Q000032:analysis*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000295:instrumentation
chemical_list: D004396:Coloring Agents; D008055:Lipids; D010575:Pesticides; D004364:Pharmaceutical Preparations; D011506:Proteins