title: Quantitative Assessment of Circumferential Enhancement along the Wall of Cerebral Aneurysms Using MR Imaging.
abstract: The incidence of wall enhancement of cerebral aneurysms on vessel wall MR imaging has been described as higher in ruptured intracranial aneurysms than in unruptured intracranial aneurysms, but the difference in the degree of enhancement between ruptured and unruptured aneurysms is unknown. We compared the degree of enhancement between ruptured and unruptured intracranial aneurysms by using quantitative MR imaging measures.
  
  
  
  We performed quantitative analyses of circumferential enhancement along the wall of cerebral aneurysms in 28 ruptured and 76 unruptured consecutive cases by using vessel wall MR imaging. A 3D-T1-weighted fast spin-echo sequence was obtained before and after contrast media injection, and the wall enhancement index was calculated. We then compared characteristics between ruptured and unruptured aneurysms.
  
  
  
  The wall enhancement index was significantly higher in ruptured than in unruptured aneurysms (1.70 ± 1.06 versus 0.89 ± 0.88, respectively; P = .0001). The receiver operating characteristic curve analysis found that the most reliable cutoff value of the wall enhancement index to differentiate ruptured from unruptured aneurysms was 0.53 (sensitivity, 0.96; specificity, 0.47). The wall enhancement index remained significant in the multivariate logistic regression analysis (P < .0001).
  
  
  
  Greater circumferential enhancement along the wall of cerebral aneurysms correlates with the ruptured state. A quantitative evaluation of circumferential enhancement by using vessel wall MR imaging could be useful in differentiating ruptured from unruptured intracranial aneurysms.
authors.affiliation: From the Departments of Neurosurgery (S.O., H.E.).
authors.forename: S
authors.identifier: 0000-0001-9660-7795
authors.initials: S
authors.lastname: Omodaka
authors.affiliation: From the Departments of Neurosurgery (S.O., H.E.) hideendo@gmail.com.
authors.forename: H
authors.identifier: 0000-0003-1472-6032
authors.initials: H
authors.lastname: Endo
authors.affiliation: Department of Neurosurgery (K.N., M.F., T.T.), Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: K
authors.identifier: 0000-0001-9282-6499
authors.initials: K
authors.lastname: Niizuma
authors.affiliation: Department of Neurosurgery (K.N., M.F., T.T.), Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: M
authors.identifier: 0000-0002-0991-0516
authors.initials: M
authors.lastname: Fujimura
authors.affiliation: Department of Neurosurgery (T.I.), Sendai Medical Center, Sendai, Japan.
authors.forename: T
authors.identifier: 0000-0003-0582-0908
authors.initials: T
authors.lastname: Inoue
authors.affiliation: Neuroendovascular Therapy (K.S.).
authors.forename: K
authors.identifier: 0000-0003-2638-771X
authors.initials: K
authors.lastname: Sato
authors.affiliation: Neuroanesthesia (S.-i.S.), Kohnan Hospital, Sendai, Japan.
authors.forename: S-I
authors.identifier: 0000-0002-0406-8307
authors.initials: SI
authors.lastname: Sugiyama
authors.affiliation: Department of Neurosurgery (K.N., M.F., T.T.), Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: T
authors.identifier: 0000-0003-3411-2900
authors.initials: T
authors.lastname: Tominaga
mesh_terms: D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods
chemical_list: D003287:Contrast Media