title: Protective Effect of Parsley Juice (Petroselinum crispum, Apiaceae) against Cadmium Deleterious Changes in the Developed Albino Mice Newborns (Mus musculus) Brain.
abstract: Parsley was used as a probe of the current experiment to prevent the behavioral, morphological and biochemical changes in the newborn brain following the administration of cadmium (Cd) to the pregnant mice. The nonanesthetized pregnant mice were given daily parsley juice (Petroselinum crispum) at doses of 20 mg/kg and 10 mg/kg. Pregnant mothers were given Cd at a dose of 30 mg/kg divided into 3 equal times. The newborns have been divided into 6 groups: Group A, mothers did not take treatment; Groups B and C, mothers were treated with low and high dose of parsley, respectively; Group D, mothers were treated only with Cd (perinatal intoxication); Groups E and F, mothers were treated with Cd doses and protected by low and high doses of parsley, respectively. Light microscopy showed that Cd-induced neuronal degeneration by chromatolysis and pyknosis in the brain regions. The low dose of parsley 10 g/kg/day exhibited significant effects in neutralizing and reducing the deleterious changes due to Cd exposure during pregnancy on the behavioral activities, neurotransmitters, oxidative stress, and brain neurons morphology of the mice newborns.
authors.affiliation: Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Allam
authors.affiliation: Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Salah N
authors.initials: SN
authors.lastname: Maodaa
authors.affiliation: Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt.
authors.forename: Rasha
authors.initials: R
authors.lastname: Abo-Eleneen
authors.affiliation: Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Jamaan
authors.initials: J
authors.lastname: Ajarem
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000254:growth & development; D002104:Cadmium / Q000633:toxicity*; D019610:Cytoprotection / Q000187:drug effects; D005260:Female; D000067030:Fruit and Vegetable Juices; D008297:Male; D051379:Mice; D009410:Nerve Degeneration / Q000473:pathology / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D028528:Petroselinum / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology / Q000517:prevention & control
chemical_list: D018696:Neuroprotective Agents; D010936:Plant Extracts; D002104:Cadmium