title: Clinical outcomes of osteonecrosis of the femoral head after autologous bone marrow stem cell implantation: a meta-analysis of seven case-control studies.
abstract: The purpose of this study was to evaluate the clinical outcomes of osteonecrosis of the femoral head after autologous bone marrow stem cell implantation. We searched the PubMed, Embase and Web of Science databases and included all case-control trials that reported on the clinical outcomes of osteonecrosis progression, incidence of total hip arthroplasty and improvement in Harris hip scores. Overall, seven case-control trials were included. Compared with the controls, patients treated with the bone marrow stem cells implantation treatment showed improved clinical outcomes with delayed osteonecrosis progression (odds ratio = 0.17, 95% CI: 0.09 - 0.32; p <0.001), a lower total hip arthroplasty incidence (odds ratio = 0.30, 95% CI: 0.12 - 0.72; p <0.01) and increased Harris hip scores (mean difference = 4.76, 95% CI: 1.24 - 8.28; p<0.01). The heterogeneity, publication bias, and sensitivity analyses showed no statistical difference significant differences between studies. Thus, our study suggests that autologous bone marrow stem cells implantation has a good therapeutic effect on osteonecrosis of the femoral, resulting in beneficial clinical outcomes. However, trials with larger sample sizes are needed to confirm these findings.
authors.affiliation: Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Heng-Feng
authors.initials: HF
authors.lastname: Yuan
authors.affiliation: Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Chang-An
authors.initials: CA
authors.lastname: Guo
authors.affiliation: Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Zuo-Qin
authors.initials: ZQ
authors.lastname: Yan
mesh_terms: D016026:Bone Marrow Transplantation / Q000379:methods*; D005271:Femur Head Necrosis / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D010020:Osteonecrosis / Q000601:surgery*; D016896:Treatment Outcome