title: Tumor Stroma Manipulation By MSC.
abstract: Tumor stroma (TS) plays relevant roles in all steps of cancer development. We here address several fundamental aspects related with the interaction between cancer cells and their stromal counterparts. Dissecting these players is of pivotal importance to understand oncogenesis, immunoescape and drug resistance. In addition, this better comprehension will allow the introduction of novel and more effective therapeutic approaches where manipulated stromal elements may become detrimental for tumor growth. Our group and others rely on the use of multipotent mesenchymal stromal/stem cells (MSC) as anti-cancer tools, since these putative TS cell precursors can deliver potent apoptosis-inducing agents. Multimodal-armed MSC can target a variety of cancers in vitro and, when injected in vivo, they localize into tumors mediating cell death without evident toxicities to normal tissues. While several aspects of these strategies shall require further investigations, these approaches collectively indicate how TS manipulation by MSC represents a tool to influence the fate of cancer cells, creating a new generation of anti-cancer strategies.
authors.forename: Giulia
authors.initials: G
authors.lastname: Grisendi
authors.forename: Carlotta
authors.initials: C
authors.lastname: Spano
authors.forename: Filippo
authors.initials: F
authors.lastname: Rossignoli
authors.forename: Naomi
authors.initials: N
authors.lastname: D Souza
authors.forename: Giulia
authors.initials: G
authors.lastname: Golinelli
authors.forename: Agnese
authors.initials: A
authors.lastname: Fiori
authors.forename: Edwin M
authors.initials: EM
authors.lastname: Horwitz
authors.forename: Valentina
authors.initials: V
authors.lastname: Guarneri
authors.forename: Federico
authors.initials: F
authors.lastname: Piacentini
authors.forename: Paolo
authors.initials: P
authors.lastname: Paolucci
authors.affiliation: Laboratory of Cellular Therapy Department of Medical and Surgical Sciences for Children & Adults University-Hospital of Modena and Reggio Emilia Via del Pozzo 71, 41124 Modena, Italy. massimo.dominici@unimore.it.
authors.forename: Massimo
authors.initials: M
authors.lastname: Dominici
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D017154:Stromal Cells / Q000166:cytology*