title: Analysis of enzyme-responsive peptide surfaces by Raman spectroscopy.
abstract: We report on the use of Raman spectroscopy as a tool to characterise model peptide functionalised surfaces. By taking advantage of Raman reporters built into the peptide sequence, the enzymatic hydrolysis of these peptides could be determined.
authors.affiliation: WestCHEM, Department of Pure & Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK.
authors.forename: Jugal Kishore
authors.initials: JK
authors.lastname: Sahoo
authors.affiliation: Centre of Molecular Nanometrology, WestCHEM, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK. Duncan.graham@strath.ac.uk and Department of Chemistry, University of Sri Jayewardenepura, Sri Lanka.
authors.forename: Narayana M S
authors.initials: NM
authors.lastname: Sirimuthu
authors.affiliation: University of Nottingham, School of Pharmacy, University Park, Boots Science Building, Nottingham, NG7 2RD, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Canning
authors.affiliation: University of Nottingham, School of Pharmacy, University Park, Boots Science Building, Nottingham, NG7 2RD, UK and National Physical Laboratory, Hampton Rd, Teddington, Middlesex TW11 0LW, UK.
authors.forename: Mischa
authors.initials: M
authors.lastname: Zelzer
authors.affiliation: Centre of Molecular Nanometrology, WestCHEM, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK. Duncan.graham@strath.ac.uk.
authors.forename: Duncan
authors.initials: D
authors.lastname: Graham
authors.affiliation: WestCHEM, Department of Pure & Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK and Advanced Science Research Center (ASRC) and Hunter College, City University of New York, NY 10031, NY, USA. Rein.Ulijn@asrc.cuny.edu.
authors.forename: Rein V
authors.initials: RV
authors.lastname: Ulijn
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006868:Hydrolysis; D008962:Models, Theoretical; D010179:Pancreas / Q000201:enzymology; D010196:Pancreatic Elastase / Q000737:chemistry / Q000378:metabolism*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D013059:Spectrum Analysis, Raman; D013499:Surface Properties; D013552:Swine
chemical_list: D010455:Peptides; D010196:Pancreatic Elastase