title: Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy.
abstract: The roles of the epidermal growth factor receptor (EGFR) signaling pathway in various cancers including breast, bladder, brain, colorectal, esophageal, gastric, head and neck, hepatocellular, lung, neuroblastoma, ovarian, pancreatic, prostate, renal and other cancers have been keenly investigated since the 1980's. While the receptors and many downstream signaling molecules have been identified and characterized, there is still much to learn about this pathway and how its deregulation can lead to cancer and how it may be differentially regulated in various cell types. Multiple inhibitors to EGFR family members have been developed and many are in clinical use. Current research often focuses on their roles and other associated pathways in cancer stem cells (CSCs), identifying sites where therapeutic resistance may develop and the mechanisms by which microRNAs (miRs) and other RNAs regulate this pathway. This review will focus on recent advances in these fields with a specific focus on breast cancer and breast CSCs. Relatively novel areas of investigation, such as treatments for other diseases (e.g., diabetes, metabolism, and intestinal parasites), have provided new information about therapeutic resistance and CSCs.
authors.forename: Linda S
authors.initials: LS
authors.lastname: Steelman
authors.forename: Timothy
authors.initials: T
authors.lastname: Fitzgerald
authors.forename: Kvin
authors.initials: K
authors.lastname: Lertpiriyapong
authors.forename: Lucio
authors.initials: L
authors.lastname: Cocco
authors.forename: Matilde Y
authors.initials: MY
authors.lastname: Follo
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Martelli
authors.forename: Luca M
authors.initials: LM
authors.lastname: Neri
authors.forename: Sandra
authors.initials: S
authors.lastname: Marmiroli
authors.forename: Massimo
authors.initials: M
authors.lastname: Libra
authors.forename: Saverio
authors.initials: S
authors.lastname: Candido
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Nicoletti
authors.forename: Aurora
authors.initials: A
authors.lastname: Scalisi
authors.forename: Concettina
authors.initials: C
authors.lastname: Fenga
authors.forename: Lyudmyla
authors.initials: L
authors.lastname: Drobot
authors.forename: Dariusz
authors.initials: D
authors.lastname: Rakus
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Gizak
authors.forename: Piotr
authors.initials: P
authors.lastname: Laidler
authors.forename: Joanna
authors.initials: J
authors.lastname: Dulinska-Litewka
authors.forename: Joerg
authors.initials: J
authors.lastname: Basecke
authors.forename: Sanja
authors.initials: S
authors.lastname: Mijatovic
authors.forename: Danijela
authors.initials: D
authors.lastname: Maksimovic-Ivanic
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Montalto
authors.forename: Melchiorre
authors.initials: M
authors.lastname: Cervello
authors.forename: Michelle
authors.initials: M
authors.lastname: Milella
authors.forename: Agustino
authors.initials: A
authors.lastname: Tafuri
authors.forename: Zoya
authors.initials: Z
authors.lastname: Demidenko
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Abrams
authors.affiliation: Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Brody Building 5N98C, Greenville, NC 27858 USA. mccubreyj@ecu.edu.
authors.forename: James A
authors.initials: JA
authors.lastname: McCubrey
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005260:Female; D006801:Humans; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D066246:ErbB Receptors