title: Eutypenoids A-C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1.
abstract: Eutypenoids A-C (1-3), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass spectroscopy (MS), nuclear magnetic resonance (NMR), X-ray crystallography, and electronic circular dichroism (ECD) analysis. The immunosuppressive effects of eutypenoids A-C (1-3) were studied using a ConA-induced splenocyte proliferation model, which suggested that 2 exhibited potent immunosuppressive activities.
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. 04100217@163.com.
authors.forename: Liu-Qiang
authors.initials: LQ
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. chen7673@163.com.
authors.forename: Xiao-Chong
authors.initials: XC
authors.lastname: Chen
authors.affiliation: Shanghai Institute of Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. zqchen@simm.ac.cn.
authors.forename: Zhao-Qiang
authors.initials: ZQ
authors.lastname: Chen
authors.affiliation: Shanghai Institute of Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. gmwang@simm.ac.cn.
authors.forename: Gui-Min
authors.initials: GM
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. jusco105@163.com.
authors.forename: Shi-Guo
authors.initials: SG
authors.lastname: Zhu
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. yangyifu@mail.shcnc.ac.cn.
authors.forename: Yi-Fu
authors.initials: YF
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. kxchen@simm.ac.cn.|Shanghai Institute of Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. kxchen@simm.ac.cn.
authors.forename: Kai-Xian
authors.initials: KX
authors.lastname: Chen
authors.affiliation: Department of Biochemistry and Molecular Biology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China. biolxy@163.com.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. ymli@shutcm.edu.cn.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Li
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001110:Arctic Regions; D001203:Ascomycota / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D002942:Circular Dichroism; D003208:Concanavalin A / Q000494:pharmacology; D018360:Crystallography, X-Ray; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008807:Mice, Inbred BALB C; D012988:Soil Microbiology; D013154:Spleen / Q000166:cytology / Q000187:drug effects
chemical_list: D045784:Abietanes; D007166:Immunosuppressive Agents; D003208:Concanavalin A
keywords: Arctic fungi; Eutypella; eutypenoid; immunosuppressive effect; novel pimarane diterpenes