title: Safety of classical swine fever virus vaccine strain LOM in pregnant sows and their offspring.
abstract: The present study aimed to evaluate the safety of the classical swine fever virus (CSFV) vaccine strain LOM in pregnant sows. Pregnant sows with free CSFV antibody were inoculated with a commercial LOM vaccine during early pregnancy (day 38; n=3) or mid-pregnancy (days 49-59; n=11). In pregnant sows vaccinated during the early stages of gestation, abortion (day 109) was observed in one case, with two stillbirths and seven mummified fetuses. The viability of live-born piglets was 34.9% in sows vaccinated during mid-pregnancy compared with 81.8% in the control group. Post-mortem examination of the organs of the sows and piglets did not reveal any pathological lesions caused by CSFV; however, CSFV RNA was detected in the organs of several vaccinated sows and their litters. The LOM strain was transmitted from sows with free CSFV antibody to their fetus, but did not appear to induce immune tolerance in the offspring from vaccinated pregnant sows. Side effects were not observed in pregnant sows with antibody to the LOM strain: transmission from sow to their litters and stillbirth or mummified fetuses. The LOM strain may induce sterile immunity and provide rapid, long-lasting, and complete protection against CSFV; however, it should be contraindicated in pregnant sows due to potential adverse effects in pregnant sows with free CSFV antibody.
authors.affiliation: Animal and Plant Quarantine Agency (QIA), 175 Anayangro Manangu Anyangsi, Gyeonggido 430-824, South Korea.
authors.forename: Seong-In
authors.initials: SI
authors.lastname: Lim
authors.affiliation: Animal and Plant Quarantine Agency (QIA), 175 Anayangro Manangu Anyangsi, Gyeonggido 430-824, South Korea.
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Song
authors.affiliation: Animal and Plant Quarantine Agency (QIA), 175 Anayangro Manangu Anyangsi, Gyeonggido 430-824, South Korea.
authors.forename: Jaejo
authors.initials: J
authors.lastname: Kim
authors.affiliation: Animal and Plant Quarantine Agency (QIA), 175 Anayangro Manangu Anyangsi, Gyeonggido 430-824, South Korea.
authors.forename: Bang-Hun
authors.initials: BH
authors.lastname: Hyun
authors.affiliation: Animal and Plant Quarantine Agency (QIA), 175 Anayangro Manangu Anyangsi, Gyeonggido 430-824, South Korea.
authors.forename: Ha-Young
authors.initials: HY
authors.lastname: Kim
authors.affiliation: Animal and Plant Quarantine Agency (QIA), 175 Anayangro Manangu Anyangsi, Gyeonggido 430-824, South Korea.
authors.forename: In-Soo
authors.initials: IS
authors.lastname: Cho
authors.affiliation: Animal and Plant Quarantine Agency (QIA), 175 Anayangro Manangu Anyangsi, Gyeonggido 430-824, South Korea.
authors.forename: Byounghan
authors.initials: B
authors.lastname: Kim
authors.affiliation: Department of Clinical Laboratory Science, Semyung University, Semyung-ro 65, Jecheon, Chungbuk 390-711, South Korea.
authors.forename: Gye-Hyeong
authors.initials: GH
authors.lastname: Woo
authors.affiliation: Konkuk University, 1 Hawayangdong Gwangjingu, Seoul 143-701, South Korea.
authors.forename: Jung-Bok
authors.initials: JB
authors.lastname: Lee
authors.affiliation: Animal and Plant Quarantine Agency (QIA), 175 Anayangro Manangu Anyangsi, Gyeonggido 430-824, South Korea. Electronic address: andj67@korea.kr.
authors.forename: Dong-Jun
authors.initials: DJ
authors.lastname: An
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D006691:Classical Swine Fever / Q000517:prevention & control*; D006692:Classical Swine Fever Virus; D000075202:Contraindications; D005260:Female; D007108:Immune Tolerance; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D011247:Pregnancy; D012367:RNA, Viral / Q000302:isolation & purification; D013552:Swine; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral; D014765:Viral Vaccines
keywords: Classical swine fever virus; LOM strain; Pregnant sows; Safety