title: Reply to G. Nasti and A. Ottaiano and to A. Avallone and A. Budillon.
authors.affiliation: University Hospital Grosshadern, Munich, and German Cancer Consortium and German Cancer Research Centre, Heidelberg, Germany.
authors.forename: Dominik Paul
authors.initials: DP
authors.lastname: Modest
authors.affiliation: ClinAssess, Leverkusen, Germany.
authors.forename: Swantje
authors.initials: S
authors.lastname: Held
authors.affiliation: University Hospital Grosshadern, Munich, and German Cancer Consortium and German Cancer Research Centre, Heidelberg, Germany volker.heinemann@med.uni-muenchen.de.
authors.forename: Volker
authors.initials: V
authors.lastname: Heinemann