title: Alterations of diffusion tensor MRI parameters in the brains of patients with Parkinson's disease compared with normal brains: possible diagnostic use.
abstract: OBJECTIVE
  To investigate the diagnostic performance of diffusion tensor imaging in patients with Parkinson's disease (PD).
  
  
  METHODS
  We examined a total of 126 PD patients (68 males/58 females, mean age: 62.0 ±7.6 years) and 91 healthy controls (43 males/48 females, mean age: 59.8 ±7.2 years). Images were acquired on a 3 Tesla magnetic resonance scanner. The Camino software was used to normalize and parcellate diffusion-weighted images into 90 cerebral regions based on the automatic anatomical labelling template. The minimum, median, and maximum values of the mean/radial/axial diffusivity/fractional anisotropy were determined. The diagnostic performance was assessed by receiver operating characteristic analysis. The associations of imaging parameters with disease severity were tested using Pearson's correlation coefficients after adjustment for disease duration.
  
  
  RESULTS
  Compared with healthy controls, PD patients showed increased diffusivity in multiple cortical regions that extended beyond the basal ganglia. An area under curve of 85 % was identified for the maximum values of mean diffusivity in the ipsilateral middle temporal gyrus. The most significant intergroup difference was 26.8 % for the ipsilateral inferior parietal gyrus.
  
  
  CONCLUSIONS
  The measurement of water diffusion from the parcellated cortex may be clinically useful for the assessment of PD patients.
  
  
  CONCLUSIONS
  • Increased diffusivity was identified in multiple cortical regions of Parkinson's disease patients. • The area under the receiver operating curve was 85 % in the middle temporal gyrus. • The ipsilateral inferior parietal gyrus showed the most significant change.
authors.affiliation: Division of Movement Disorders,Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.|Neuroscience Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.|School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Chin-Song
authors.initials: CS
authors.lastname: Lu
authors.affiliation: Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taiwan.|Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 WenHua 1st Road, Taoyuan County, 333, Taiwan.
authors.forename: Shu-Hang
authors.initials: SH
authors.lastname: Ng
authors.affiliation: Division of Movement Disorders,Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.|Neuroscience Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.|School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Yi-Hsin
authors.initials: YH
authors.lastname: Weng
authors.affiliation: Clinical Informatics and Medical Statistics Research Center,College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Jur-Shan
authors.initials: JS
authors.lastname: Cheng
authors.affiliation: Division of Movement Disorders,Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.|Neuroscience Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.|School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Wey-Yil
authors.initials: WY
authors.lastname: Lin
authors.affiliation: Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Keelung, Taiwan.
authors.forename: Yau-Yau
authors.initials: YY
authors.lastname: Wai
authors.affiliation: Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taiwan.|Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Keelung, Taiwan.
authors.forename: Yao-Liang
authors.initials: YL
authors.lastname: Chen
authors.affiliation: Neuroscience Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan. jwang@mail.cgu.edu.tw.|Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taiwan. jwang@mail.cgu.edu.tw.|Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 WenHua 1st Road, Taoyuan County, 333, Taiwan. jwang@mail.cgu.edu.tw.|Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University / Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. jwang@mail.cgu.edu.tw.
authors.forename: Jiun-Jie
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D016880:Anisotropy; D019540:Area Under Curve; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology*; D012372:ROC Curve
keywords: Computer assisted diagnosis; Diffusion tensor imaging; Parietal lobule; Parkinson’s disease; Temporal gyrus