title: Memory Deficit Recovery after Chronic Vanadium Exposure in Mice.
abstract: Vanadium is a transitional metal with an ability to generate reactive oxygen species in the biological system. This work was designed to assess memory deficits in mice chronically exposed to vanadium. A total of 132 male BALB/c mice (4 weeks old) were used for the experiment and were divided into three major groups of vanadium treated, matched controls, and animals exposed to vanadium for three months and thereafter vanadium was withdrawn. Animals were tested using Morris water maze and forelimb grip test at 3, 6, 9, and 12 months of age. The results showed that animals across the groups showed no difference in learning but had significant loss in memory abilities after 3 months of vanadium exposure and this trend continued in all vanadium-exposed groups relative to the controls. Animals exposed to vanadium for three months recovered significantly only 9 months after vanadium withdrawal. There was no significant difference in latency to fall in the forelimb grip test between vanadium-exposed groups and the controls in all age groups. In conclusion, we have shown that chronic administration of vanadium in mice leads to memory deficit which is reversible but only after a long period of vanadium withdrawal.
authors.affiliation: Neuroscience Unit, Department of Veterinary Anatomy, University of Ibadan, Ibadan 20001, Nigeria; Department of Anatomy, Ladoke Akintola University, Ogbomosho 21001, Nigeria.
authors.forename: Oluwabusayo
authors.initials: O
authors.lastname: Folarin
authors.affiliation: Department of Anatomy, University of Ibadan, Ibadan 20001, Nigeria.
authors.forename: Funmilayo
authors.initials: F
authors.lastname: Olopade
authors.affiliation: Neuroscience Unit, Department of Veterinary Anatomy, University of Ibadan, Ibadan 20001, Nigeria.
authors.forename: Silas
authors.initials: S
authors.lastname: Onwuka
authors.affiliation: Neuroscience Unit, Department of Veterinary Anatomy, University of Ibadan, Ibadan 20001, Nigeria.
authors.forename: James
authors.initials: J
authors.lastname: Olopade
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D004781:Environmental Exposure; D018737:Hand Strength; D008297:Male; D018782:Maze Learning; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000503:physiopathology / Q000534:rehabilitation*; D051379:Mice; D008807:Mice, Inbred BALB C; D053580:Muscle Strength / Q000187:drug effects; D020127:Recovery of Function / Q000187:drug effects*; D013997:Time Factors; D014639:Vanadium / Q000494:pharmacology*
chemical_list: D014639:Vanadium