title: Creating Shareable Clinical Decision Support Rules for a Pharmacogenomics Clinical Guideline Using Structured Knowledge Representation.
abstract: Pharmacogenomics (PGx) guidelines contain drug-gene relationships, therapeutic and clinical recommendations from which clinical decision support (CDS) rules can be extracted, rendered and then delivered through clinical decision support systems (CDSS) to provide clinicians with just-in-time information at the point of care. Several tools exist that can be used to generate CDS rules that are based on computer interpretable guidelines (CIG), but none have been previously applied to the PGx domain. We utilized the Unified Modeling Language (UML), the Health Level 7 virtual medical record (HL7 vMR) model, and standard terminologies to represent the semantics and decision logic derived from a PGx guideline, which were then mapped to the Health eDecisions (HeD) schema. The modeling and extraction processes developed here demonstrate how structured knowledge representations can be used to support the creation of shareable CDS rules from PGx guidelines.
authors.affiliation: Department of Biomedical Informatics, Arizona State University, Scottsdale, AZ.
authors.forename: Margaret K
authors.initials: MK
authors.lastname: Linan
authors.affiliation: Department of Biomedical Informatics, Arizona State University, Scottsdale, AZ; Office of Information and Knowledge Management, Mayo Clinic, Rochester, MN.
authors.forename: Davide
authors.initials: D
authors.lastname: Sottara
authors.affiliation: Office of Information and Knowledge Management, Mayo Clinic, Rochester, MN; Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Freimuth
mesh_terms: D020000:Decision Support Systems, Clinical; D057208:Health Level Seven; D006801:Humans; D010597:Pharmacogenetics; D017410:Practice Guidelines as Topic