title: Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure.
abstract: Here we present data on liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure. Archived liver samples from rhesus monkeys exposed to 0 (n=6), 0.06 (n=6), 0.3 (n=4) and 1.5 (n=4) mg/m(3) manganese inhalation for 65 days were obtained from a published study ("Tissue manganese concentrations in young male rhesus monkeys following subchronic manganese sulfate inhalation" [1]). Samples were analyzed by spectroscopy, immunoblotting and quantitative PCR to assess metal levels and gene expression. Liver manganese and iron levels were linearly correlated although only the intermediate manganese exposure level (0.3 mg Mn/m(3)) led to a statistically significant increase in liver iron levels.
authors.affiliation: Brown University, Department of Pathology and Laboratory Medicine, 70 Ship St., Rm. 522, Providence, RI 02912, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pettiglio
authors.affiliation: Brown University, Department of Pathology and Laboratory Medicine, 70 Ship St., Rm. 522, Providence, RI 02912, USA.
authors.forename: Carolina
authors.initials: C
authors.lastname: Herrera
authors.affiliation: North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, NC 27607, USA.
authors.forename: Melanie L
authors.initials: ML
authors.lastname: Foster
authors.affiliation: North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, NC 27607, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Dorman
authors.affiliation: Brown University, Department of Pathology and Laboratory Medicine, 70 Ship St., Rm. 522, Providence, RI 02912, USA.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Bartnikas
keywords: Inhalation; Iron; Manganese; Monkey