title: No association between ZNF804A rs1344706 and schizophrenia in a case-control study of Han Chinese.
abstract: Previous studies indicated that the single nucleotide polymorphism (SNP) rs1344706 within the gene ZNF804A was a promising risk variant for schizophrenia in European populations. However, existing results are inconsistent in Han Chinese. Hoping to validate the association of rs1344706 with schizophrenia susceptibility in Han Chinese, we conducted a case-control study in 1284 cases and 990 healthy controls from Jiangsu Province, China. We did not detect any significant between-group difference (all P>0.05) in either allele or genotype frequency under any genetic model between cases and controls. Stratified analysis by sex also failed to find any significant association. Our results did not support the association of rs1344706 with schizophrenia in Han Chinese, and further association studies with large samples from other ethnic backgrounds and focus on more SNPs of ZNF804A are warranted.
authors.affiliation: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu 214151, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China.
authors.forename: Shuidi
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Unit on Statistical Genomics, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
authors.forename: Yin Yao
authors.initials: YY
authors.lastname: Shugart
authors.affiliation: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu 214151, China.
authors.forename: Zhenhe
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu 214151, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Jin
authors.affiliation: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu 214151, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu 214151, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu 214151, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu 214151, China. Electronic address: chengzaohuo@126.com.
authors.forename: Zaohuo
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu 214151, China. Electronic address: zhangfq@njmu.edu.cn.
authors.forename: Fuquan
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult; D016335:Zinc Fingers
chemical_list: D051741:Kruppel-Like Transcription Factors; C540527:ZNF804A protein, human
keywords: Han Chinese; Schizophrenia; Zinc finger protein 804A; rs1344706