title: The curative effects of LPN combined LCA in treating with middle and advanced renal cancer.
abstract: OBJECTIVE
  To discuss the curative effects of laparoscopy partial nephrectomy (LPN) combined with laparoscopy cryoablation (LCA) in treating renal cancer.
  
  
  METHODS
  A total of 58 patients that were diagnosed with phase III-IV renal cancer in the Hospital from February 2013 to October 2014 were enrolled in this study. After obtaining the approval of Ethics Committee of the Hospital as well as the informed consent of the patients and their relatives, the patients were randomly divide into two groups: control group consisted of 24 patients, who were treated with LPN + chemo radiotherapy and the observation group consisted of 34 patients, who were treated with LPN in combination of LCA + chemo radiotherapy.
  
  
  RESULTS
  The rate of successful operation was significantly higher in the observation group than in control group and the prevalence of per procedural complications in observation group was significantly lower than that of control group, and these differences had statistical significance (p < 0.05). Glomerular filtration rate (eGFR) after operation and 6-month follow-up in observation group was significantly higher than that in control group, and the level of serum creatinine (sCr) was significantly lower compared to the control group and the differences had statistical significance (p < 0.05). Follow-up survival rate of patients in the observation group was significantly higher than that of control group, recurrence rate and recurrence time of patients in the observation group was significantly lower than those of control group and the difference had statistical significance (p < 0.05).
  
  
  CONCLUSIONS
  LPN combined LCA therapy was quite effective in treating with middle and advanced renal cancer. Compared with pure LPN therapy, LPN combined LCA therapy could significantly improve the surgical effects, retain the functions of the renal unit and improve the patients' prognosis.
authors.affiliation: Department of Urology, the Affiliated Hexian Memorial Hospital of Southern Medical University Guangzhou, Guangdong, China. doctorqiumin@163.com.
authors.forename: M-J
authors.initials: MJ
authors.lastname: Qiu
authors.forename: H
authors.initials: H
authors.lastname: Tian
authors.forename: C
authors.initials: C
authors.lastname: Pang
authors.forename: Z-J
authors.initials: ZJ
authors.lastname: Yang
authors.forename: C-Q
authors.initials: CQ
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Xu
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy / Q000639:trends; D003452:Cryosurgery / Q000639:trends; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology; D007677:Kidney Function Tests / Q000639:trends; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D010535:Laparoscopy / Q000639:trends; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000639:trends; D011379:Prognosis; D015996:Survival Rate / Q000639:trends