title: The value of local normal limits in quantitative Thallium-201 CZT MPI SPECT.
abstract: Considering the distinctive characteristics of CZT detectors, automatic quantification of ischemia using normal limits included with software package may deliver suboptimal results for CAD detection. The present study aims to evaluate the benefits of creating normal limits specific to a local population and laboratory protocol.
  
  
  
  Two groups were selected from patients who had undergone a CZT MPI. Normal limits were generated with the QPS application based on the population with low likelihood of CAD. Using the vendor-supplied and the population-specific normal limits i-TPD and vessel-specific SDS results obtained for patients who had subsequently undergone coronary angiography were compared with coronary angiography data. A weak correlation was observed for low i-TPD (stress TPD minus rest TPD) and SDS values. Both databases gave similar values for the area under the ROC curve concerning i-TPD (0.75 to 0.74) and SDS results (0.72 to 0.75 for the LAD, 0.62 to 0.64 for the LCx, and 0.63 to 0.67 for the RCA). Sensitivity (60%), specificity (78%), and predictive positive (84%) and negative (52%) values were also similar with a diagnostic and prognostic threshold value.
  
  
  
  The use of a population-specific created database did not influence the diagnostic value of thallium-201 MPI QPS results using a CZT camera.
authors.affiliation: Centre de Medicine Nucléaire, Hôpital Louis Pradel, 28, Avenue Doyen Lépine, 69500, Bron, France. bastien.gregoire@chu-lyon.fr.|Université Claude Bernard LYON 1, Faculté de Médecine de Lyon Est., 8 avenue Rockefeller, 69008, Lyon, France. bastien.gregoire@chu-lyon.fr.
authors.forename: Bastien
authors.initials: B
authors.lastname: Gregoire
authors.affiliation: Centre de Medicine Nucléaire, Hôpital Louis Pradel, 28, Avenue Doyen Lépine, 69500, Bron, France.|Université Claude Bernard LYON 1, Faculté de Médecine de Lyon Est., 8 avenue Rockefeller, 69008, Lyon, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Pina-Jomir
authors.affiliation: Centre de Medicine Nucléaire, Hôpital Louis Pradel, 28, Avenue Doyen Lépine, 69500, Bron, France.|Université Claude Bernard LYON 1, Faculté de Médecine de Lyon Est., 8 avenue Rockefeller, 69008, Lyon, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Bontemps
authors.affiliation: Centre de Medicine Nucléaire, Hôpital Louis Pradel, 28, Avenue Doyen Lépine, 69500, Bron, France.|Université Claude Bernard LYON 1, Faculté de Médecine de Lyon Est., 8 avenue Rockefeller, 69008, Lyon, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Janier
authors.affiliation: Centre de Medicine Nucléaire, Hôpital Louis Pradel, 28, Avenue Doyen Lépine, 69500, Bron, France.|Université Claude Bernard LYON 1, Faculté de Médecine de Lyon Est., 8 avenue Rockefeller, 69008, Lyon, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Scheiber
mesh_terms: D002104:Cadmium / Q000528:radiation effects; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000592:standards*; D011877:Radionuclide Imaging / Q000379:methods / Q000592:standards*; D019275:Radiopharmaceuticals; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013691:Tellurium / Q000528:radiation effects; D013794:Thallium Radioisotopes / Q000592:standards*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods / Q000592:standards*; D015032:Zinc / Q000528:radiation effects
chemical_list: C474490:CdZnTe; D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; D002104:Cadmium; D015032:Zinc; D013691:Tellurium
keywords: CZT camera; Myocardial perfusion imaging; SPECT; normal limits; quantification; thallium-201