title: Utility of MRI Diffusion Tensor Imaging in Carpal Tunnel Syndrome: A Meta-Analysis.
abstract: BACKGROUND After successful utilization of diffusion tensor imaging (DTI) in detecting brain pathologies, it is now being examined for use in the detection of peripheral neuropathies. The aim of this meta-analysis was to evaluate the diagnostic potentials of DTI in carpal tunnel syndrome (CTS). MATERIAL AND METHODS The literature search was performed in multiple electronic databases using a keyword search and final selection of the studies was based on predetermined inclusion and exclusion criteria. We performed a meta-analyses of mean differences in fractional anisotropy (FA) and apparent diffusion coefficient (ADC) between CTS patient and healthy subjects. Publication bias detection was done with Begg's test and sensitivity analyses were performed to explore the source/s of higher heterogeneity and the authenticity of results. RESULTS FA was significantly lower in CTS patients in comparison with healthy subjects (mean and the difference [95% confidence interval] was -0.06 [-0.10, -0.02] (p=0.003). The ADC was significantly higher in CTS patients (mean difference [95% CI] was 0.10 [0.02, 0.18], p=0.02). Overall sensitivity of FA-based diagnosis was 82.82%, with 77.83% specificity. CONCLUSIONS DTI can be a valuable tool in diagnosing CTS.
authors.affiliation: Department of Radiology, Second Affiliated Hospital, Xin-jiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Radiology, Second Affiliated Hospital, Xin-jiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Jingxu
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Radiology, Second Affiliated Hospital, Xin-jiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Liping
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Second Affiliated Hospital, Xin-jiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Yunling
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, Second Affiliated Hospital, Xin-jiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Jia
mesh_terms: D016880:Anisotropy; D002349:Carpal Tunnel Syndrome / Q000175:diagnosis*; D016022:Case-Control Studies; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017594:Publication Bias; D012680:Sensitivity and Specificity