title: The emerging role of GATA transcription factors in development and disease.
abstract: The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.
authors.affiliation: Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.
authors.forename: Marjolein H F M
authors.initials: MH
authors.lastname: Lentjes
authors.affiliation: Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.
authors.forename: Hanneke E C
authors.initials: HE
authors.lastname: Niessen
authors.affiliation: Department of Molecular Oncology,Graduate School of Medicine and Dentistry,Tokyo Medical and Dental University,Tokyo,Japan.
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Akiyama
authors.affiliation: Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.
authors.forename: Adriaan P
authors.initials: AP
authors.lastname: de Bruïne
authors.affiliation: Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.
authors.forename: Veerle
authors.initials: V
authors.lastname: Melotte
authors.affiliation: Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.
authors.forename: Manon
authors.initials: M
authors.lastname: van Engeland
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000254:growth & development / Q000378:metabolism; D002454:Cell Differentiation; D002490:Central Nervous System / Q000254:growth & development / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D004707:Endoderm / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D050980:GATA Transcription Factors / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006413:Hematopoietic System / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D008648:Mesoderm / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D017092:Porphyria, Erythropoietic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: D050980:GATA Transcription Factors