title: High-dose-rate interstitial brachytherapy in oral cancer-Its impact on quality of life.
abstract: The aim of the study was to assess the impact of high-dose-rate (HDR) interstitial brachytherapy on quality of life (QOL) in oral cancer.
  
  
  
  Thirty-two patients of oral cancer treated at our institute from January 2010 to December 2014 with radical radiotherapy (external beam radiotherapy + brachytherapy) were included for analysis; 30 patients received external beam radiotherapy (50-54 Gy) and HDR brachytherapy boost (18-24.5 Gy); 2 patients received radical HDR brachytherapy (31.5 Gy). Quality of life (QOL) was assessed by Telugu, Hindi, and English versions of EORTC Quality of Life Core-30 and EORTC Quality of Life Head and Neck Module (QLQ H&N35) before treatment, at 3 months, 6 months, 1 year, and 2 years after treatment.
  
  
  
  Of the 32 patients, 2 patients died and 1 patient progressed on followup; 2 patients were re-irradiation cases. On excluding these cases, 27 patients were available for analysis. The followup duration was 6-55 months. At the time of analysis, 91% (29) patients were disease free, 3% (1) progressed, and 6% (2) died. At the end of 2 years, none of the QLQ-C30 functional scores fell below the baseline. Pain, swallowing, sensory, speech, social contact, and social eating worsened at 3 months but improved over 2 years (p < 0.001). Sexuality and financial status showed delayed improvement (p < 0.001). Among the head and neck parameters, dry mouth and sticky saliva were significant determinants of QOL with delayed improvement (p < 0.001). The impact of age, sex, and tumor stage and on QOL was analyzed. Women reported a poorer QOL for physical and emotional parameters, social eating, weight loss, and fatigue. Tumor stage significantly affected QOL, with early stages showing a better QOL.
  
  
  
  Almost all patients regained normal function after treatment and reported an excellent QOL at 2 years. However, tumor stage significantly affected the QOL.
authors.affiliation: Department of Radiation Oncology, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, India. Electronic address: harjotbajwa1987@gmail.com.
authors.forename: Harjot Kaur
authors.initials: HK
authors.lastname: Bajwa
authors.affiliation: Department of Radiation Oncology, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, India.
authors.forename: Rohith
authors.initials: R
authors.lastname: Singareddy
authors.affiliation: Department of Radiation Oncology, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, India.
authors.forename: Krishnam Raju
authors.initials: KR
authors.lastname: Alluri
mesh_terms: D001918:Brachytherapy / Q000009:adverse effects* / Q000379:methods*; D003680:Deglutition Disorders / Q000209:etiology; D004435:Eating; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D010146:Pain / Q000209:etiology; D011788:Quality of Life; D011879:Radiotherapy Dosage; D019529:Sexuality; D058992:Social Participation; D013064:Speech Disorders / Q000209:etiology; D011795:Surveys and Questionnaires; D013997:Time Factors; D014987:Xerostomia / Q000209:etiology
keywords: HDR brachytherapy; Oral cancer; Quality life