title: The Hyperpolarization-Activated Cation Current Ih: The Missing Link Connecting Cannabinoids to Cognition.
abstract: In this issue of Neuron, Maroso et al. (2016) describe a novel link between cannabinoids and cognition. They show that CB1Rs bidirectionally modulate HCN-mediated Ih in a subset of CA1 pyramidal neurons to influence both short- and long-term circuit dynamics and alter spatial working memory in behaving mice.
authors.affiliation: Program in Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Vargish
authors.affiliation: Program in Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: mcbainc@mail.nih.gov.
authors.forename: Chris J
authors.initials: CJ
authors.lastname: McBain
mesh_terms: D000818:Animals; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / Q000378:metabolism*; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism*; D065852:Spatial Memory / Q000502:physiology*; D055366:Synaptic Potentials / Q000235:genetics*
chemical_list: D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D043884:Receptor, Cannabinoid, CB1