title: Prognostic implications of mean platelet volume on short- and long-term outcomes among patients with non-ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: A single-center large observational study.
abstract: BACKGROUND
  Mean platelet volume (MPV) is a simple and reliable indicator of platelet size that correlates with platelet activation and their ability to aggregate. We studied the predictive value of MPV in patients with non-ST-segment elevation myocardial infarction (NSTEMI) treated with percutaneous coronary intervention (PCI).
  
  
  METHODS
  We analyzed the consecutive records of 1001 patients who were hospitalized due to NSTEMI at our center. The primary end point was a composite end point that included the rates of all-cause death, non-fatal myocardial infarction, and acute coronary syndrome (ACS) driven revascularization at 12 months. The enrolled patients were stratified according to the quartile of the MPV level at admission.
  
  
  RESULTS
  Along with the increasing quartile of MPV, the 12-month composite end point increased significantly (p = 0.010), and this association remained significant after the risk-adjusted analyses (per 1 fL higher MPV; adjusted hazard ratio [HR] 1.13; 95% confidence interval [CI] 1.02-1.27; p = 0.026). In the multivariate analysis, the MPV was also an independent factor of all-cause mortality (per 1 fL increase; adjusted HR 1.34; 95% CI 1.12-1.61; p = 0.0014) and death or non-fatal myocardial infarction (per 1 fL increase; adjusted HR 1.16; 95% CI 1.03-1.31; p = 0.017).
  
  
  CONCLUSIONS
  In patients with NSTEMI treated with PCI, a high MPV value was associated with a significantly increased incidence of long-term adverse events, particularly for all-cause mortality.
authors.affiliation: a 3rd Chair and Department of Cardiology, SMDZ in Zabrze , Medical University of Silesia , Katowice , Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Wasilewski
authors.affiliation: a 3rd Chair and Department of Cardiology, SMDZ in Zabrze , Medical University of Silesia , Katowice , Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Desperak
authors.affiliation: a 3rd Chair and Department of Cardiology, SMDZ in Zabrze , Medical University of Silesia , Katowice , Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Hawranek
authors.affiliation: a 3rd Chair and Department of Cardiology, SMDZ in Zabrze , Medical University of Silesia , Katowice , Poland.
authors.forename: Aneta
authors.initials: A
authors.lastname: Ciślak
authors.affiliation: a 3rd Chair and Department of Cardiology, SMDZ in Zabrze , Medical University of Silesia , Katowice , Poland.|c Genomics Laboratory, Kardio-Med Silesia Science and Technology Park , Zabrze , Poland.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Osadnik
authors.affiliation: a 3rd Chair and Department of Cardiology, SMDZ in Zabrze , Medical University of Silesia , Katowice , Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Pyka
authors.affiliation: b School of Medicine with the Division of Dentistry in Zabrze , Medical University of Silesia , Katowice , Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Gawlita
authors.affiliation: b School of Medicine with the Division of Dentistry in Zabrze , Medical University of Silesia , Katowice , Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Bujak
authors.affiliation: a 3rd Chair and Department of Cardiology, SMDZ in Zabrze , Medical University of Silesia , Katowice , Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Niedziela
authors.affiliation: b School of Medicine with the Division of Dentistry in Zabrze , Medical University of Silesia , Katowice , Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Krawczyk
authors.affiliation: a 3rd Chair and Department of Cardiology, SMDZ in Zabrze , Medical University of Silesia , Katowice , Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Gąsior
mesh_terms: D054058:Acute Coronary Syndrome; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001792:Blood Platelets; D002423:Cause of Death; D015897:Comorbidity; D017023:Coronary Angiography; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D009203:Myocardial Infarction; D000072658:Non-ST Elevated Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D062645:Percutaneous Coronary Intervention; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D010975:Platelet Aggregation Inhibitors
keywords: Long-term prognosis; mean platelet volume; non-ST-segment elevation myocardial infarction; percutaneous coronary intervention