title: Polyethylene glycol plus ascorbic acid is as effective as sodium picosulfate with magnesium citrate for bowel preparation: A randomized trial.
abstract: OBJECTIVE
  This study was aimed to evaluate the efficacy and safety of two low-volume agents, polyethylene glycol (PEG)-3350 plus ascorbic acid (PEG + Asc) and sodium picosulfate with magnesium citrate (SPMC), for bowel preparation.
  
  
  METHODS
  We performed a prospective, endoscopist-blinded, single-center, randomized controlled trial comparing PEG + Asc with SPMC to evaluate the bowel cleansing efficacy of the two regimens using the modified Ottawa bowel preparation scale (OBPS) and the Aronchick scale. Patients' taste and overall tolerance were assessed with a questionnaire.
  
  
  RESULTS
  In total, 200 patients were randomized to receive either PEG + Asc (n = 98) or SPMC (n = 102). Both treatments were similarly efficacious in bowel cleansing, based on the modified OBSP (PEG + Asc 4.01 ± 2.29 vs SPMC 3.86 ± 2.47, P = 0.62) and Aronchick scale (PEG + Asc 1.96 ± 0.70 vs SPMC 1.89 ± 0.70, P = 0.42). Patient-reported taste and tolerance of each regimen, as reported by the questionnaire, were significantly greater in the PEG + Asc group than in the SPMC group (P = 0.01). In terms of adverse events, dizziness was more frequently observed in the PEG + Asc group (P = 0.03), whereas nausea was more common in the SPMC group (P = 0.02).
  
  
  CONCLUSIONS
  PEG + Asc and SPMC show similar efficacy for bowel preparation. However, patient's overall tolerance is higher in the PEG + Asc group.
authors.affiliation: Department of Internal Medicine, Gachon Graduate School of Medicine, Gil Medical Center, Incheon, Korea.
authors.forename: Hyun-Seok
authors.initials: HS
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Gachon Graduate School of Medicine, Gil Medical Center, Incheon, Korea.
authors.forename: Jun-Won
authors.initials: JW
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Gachon Graduate School of Medicine, Gil Medical Center, Incheon, Korea.
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Gachon Graduate School of Medicine, Gil Medical Center, Incheon, Korea.
authors.forename: Min Young
authors.initials: MY
authors.lastname: Lim
authors.affiliation: Department of Internal Medicine, Gachon Graduate School of Medicine, Gil Medical Center, Incheon, Korea.
authors.forename: Dong Kyun
authors.initials: DK
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Gachon Graduate School of Medicine, Gil Medical Center, Incheon, Korea.
authors.forename: Yoon Jae
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gachon Graduate School of Medicine, Gil Medical Center, Incheon, Korea.
authors.forename: Kwang Ahn
authors.initials: KA
authors.lastname: Kwon
authors.affiliation: Department of Internal Medicine, Gachon Graduate School of Medicine, Gil Medical Center, Incheon, Korea.
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D002400:Cathartics / Q000009:adverse effects / Q000627:therapeutic use*; D002951:Citrates / Q000009:adverse effects / Q000627:therapeutic use*; D019343:Citric Acid / Q000009:adverse effects / Q000627:therapeutic use*; D003106:Colon / Q000187:drug effects*; D003113:Colonoscopy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D010349:Patient Compliance; D017060:Patient Satisfaction; D010847:Picolines / Q000009:adverse effects / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000627:therapeutic use*; D016037:Single-Blind Method; D011795:Surveys and Questionnaires
chemical_list: D002400:Cathartics; D002951:Citrates; D004338:Drug Combinations; D009942:Organometallic Compounds; D010847:Picolines; D019343:Citric Acid; D011092:Polyethylene Glycols; C005701:picosulfate sodium; D001205:Ascorbic Acid; C110422:magnesium citrate
keywords: bowel preparation regimens; colonoscopy; polyethylene glycols, ascorbic acid; sodium picosulfate, magnesium citrate