title: Cronobacter sakazakii DNA Detection in Cerebrospinal Fluid of a Patient with Amyotrophic Lateral Sclerosis Mimic Syndrome.
abstract: A 45-year-old male noticed progressive weakness of the right lower limb with gait disturbance. Over the following months, motor deficits worsened, spreading to the right upper limb. Electromyography showed active denervation in the upper and lower limb muscles. A diagnosis of amyotrophic lateral sclerosis (ALS) was made. About 2 years after symptom onset, gradual improvement occurred. Cerebrospinal fluid analysis performed about 3 years after the beginning of symptoms identified Cronobacter sakazakii. Since no other possible causes were identified, we suggest that an almost completely reversible ALS-like syndrome had been triggered by Cronobacter infection in our immunocompetent patient.
authors.affiliation: Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Piombo
authors.affiliation: Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Chiarello
authors.affiliation: Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy.
authors.forename: Marzia
authors.initials: M
authors.lastname: Corbetto
authors.affiliation: Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy; Fondazione Alberto Sordi, Institute for Ageing, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Pino
authors.affiliation: Clinical Pathology and Microbiology Laboratory, Rome, Italy.
authors.forename: Giordano
authors.initials: G
authors.lastname: Dicuonzo
authors.affiliation: Clinical Pathology and Microbiology Laboratory, Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Angeletti
authors.affiliation: Virology, Clinical Pathology and Microbiology Laboratory, University Hospital Campus Bio-Medico of Rome, Rome, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Riva
authors.affiliation: Clinical Pathology and Microbiology Laboratory, Rome, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: De Florio
authors.affiliation: Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy; Fondazione Alberto Sordi, Institute for Ageing, Rome, Italy.
authors.forename: Fioravante
authors.initials: F
authors.lastname: Capone
authors.affiliation: Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy; Fondazione Alberto Sordi, Institute for Ageing, Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Lazzaro
keywords: Amyotrophic lateral sclerosis; Cerebrospinal fluid; Cronobacter sakazakii