title: Role of Platelets in Thromboembolism in Patients with Atrial Fibrillation.
abstract: Thromboembolic complications of atrial fibrillation (AF) are a major cause of morbidity and mortality but the mechanism of its process remain poorly understood. There are many as yet unanswered questions surrounding the increased thrombotic tendency in AF. One of the crucial questions is what determines the fact that a thrombus remains in the left atrium in situ in some patients, while in others it breaks off and leads to embolic complications. Recent studies indicated an important role of platelets in the left atrial's thrombus formation and suggest that the embolic potential of left atrial thromboses depends on the involvement of platelets in the process of fibrin stabilization rather than aggregation. New methods for investigating platelets function, such as the analysis of transcription activity of RNA coming from platelets contained in thrombi formed in AF, creates an opportunity for studying populations of platelets that are directly involved in homeostatic clot formation. In this paper we present current opinions on the participation of platelets in the pathogenesis of thromboembolism in patients with AF.
authors.affiliation: Department of Angiology, Hypertension and Diabetology, Wroclaw Medical University, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Gosk-Bierska
authors.affiliation: Department of Angiology, Hypertension and Diabetology, Wroclaw Medical University, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Wasilewska
authors.affiliation: Division of Cardiology Diseases, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Waldemar
authors.initials: W
authors.lastname: Wysokiński
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000097:blood / Q000150:complications* / Q000235:genetics; D001792:Blood Platelets / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015539:Platelet Activation; D010979:Platelet Function Tests; D018570:Risk Assessment; D012307:Risk Factors; D015398:Signal Transduction; D013923:Thromboembolism / Q000097:blood / Q000209:etiology* / Q000235:genetics