title: Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.
abstract: The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.
authors.affiliation: Department of Immunology and Infection, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK Priority Area Infections, Research Center Borstel, Borstel, Germany Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
authors.forename: Emmanuel C
authors.initials: EC
authors.lastname: Patin
authors.affiliation: Department of Immunology and Infection, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Sam
authors.initials: S
authors.lastname: Willcocks
authors.affiliation: Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
authors.forename: Selinda
authors.initials: S
authors.lastname: Orr
authors.affiliation: Department of Immunology and Infection, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Theresa H
authors.initials: TH
authors.lastname: Ward
authors.affiliation: Institute of Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Lang
authors.affiliation: Department of Immunology and Infection, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK Priority Area Infections, Research Center Borstel, Borstel, Germany German Center for Infection Research, TTU-TB, Borstel, Germany uschaible@fz-borstel.de.
authors.forename: Ulrich E
authors.initials: UE
authors.lastname: Schaible
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003311:Cord Factors / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism; D053762:Interleukin-12 Subunit p40 / Q000235:genetics / Q000378:metabolism; D037181:Lectins, C-Type / Q000235:genetics / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009159:Mycobacteriaceae / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology*; D051195:Toll-Like Receptor 2 / Q000235:genetics / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
chemical_list: C113583:Clecsf8 protein, mouse; D003311:Cord Factors; D053762:Interleukin-12 Subunit p40; D037181:Lectins, C-Type; D008565:Membrane Proteins; C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2; D016753:Interleukin-10
keywords: IL-10; Mincle; Mycobacteria; macrophage; receptor