title: Four Cytotoxic Spongian Diterpenes from the Sponge Dysidea cf. arenaria.
abstract: Chemical analysis of the sponge Dysidea cf. arenaria from Irabu Island provided four new diterpenes 1-4. Their structures were elucidated by NMR and other spectroscopic analyses. All the metabolites retained the spongian skeleton and an isovalerate ester, but were different from those previously isolated from a specimen of Okinawa Island, implying geographic variation. The cytotoxicity of compounds 1-4 to NBT-T2 cells was evaluated and their IC50 values were 3.1, 1.9, 8.4, and 3.1 µM, respectively.
authors.affiliation: Department of Chemistry, Biology and Marine Science, University of the Ryukyus.
authors.forename: Mika
authors.initials: M
authors.lastname: Shingaki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Wauke
authors.forename: Peni
authors.initials: P
authors.lastname: Ahmadi
authors.forename: Junichi
authors.initials: J
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D004224:Diterpenes