title: Molecular predictive and prognostic factors in ependymoma.
abstract: An ependymoma is an uncommon glial tumor, which arises from different parts of the neuroaxis. Considerable variation in presentation and survival in tumors in different locations after an optimum treatment indicates inherent molecular and genetic differences in tumorigenesis between them. A number of genetic aberrations have been identified to distinctly characterize different subgroups of ependymomas that include a posterior fossa tumor, a supratentorial tumor, and a pediatric tumor. These different groups have substantial genetic alterations, and also distinct demography, clinical characteristics, and prognosis. This article is intended to review the diverse molecular and genetic aberrations that may be helpful in prognostication and prediction of survival in patients suffering from an ependymoma.
authors.forename: Rony
authors.initials: R
authors.lastname: Benson
authors.affiliation: Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Supriya
authors.initials: S
authors.lastname: Mallick
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Julka
authors.forename: Goura K
authors.initials: GK
authors.lastname: Rath
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics; D004806:Ependymoma / Q000175:diagnosis* / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D015192:Infratentorial Neoplasms / Q000175:diagnosis / Q000235:genetics; D011379:Prognosis; D015173:Supratentorial Neoplasms / Q000175:diagnosis / Q000235:genetics
chemical_list: D005819:Genetic Markers