title: A Prospective Randomized Experimental Study to Investigate the Eradication Rate of Endometriosis after Surgical Resection versus Aerosol Plasma Coagulation in a Rat Model.
abstract: OBJECTIVE
  To investigate the eradication rate of endometriosis after surgical resection (SR) vs. thermal ablation with aerosol plasma coagulation (AePC) in a rat model.
  
  
  METHODS
  In this prospective, randomized, controlled, single-blinded animal study endometriosis was induced on the abdominal wall of 34 female Wistar rats. After 14 days endometriosis was either removed by SR or ablated by AePC. 14 days later the rats were euthanized to evaluate the eradication rate histopathologically. Intervention times were recorded.
  
  
  RESULTS
  Eradication rate of endometriosis after 14 days did not significantly differ between AePC and SR (p=0.22). Intervention time per endometrial lesion was 22.1 s for AePC and 51.8 s for SR (p<0.0001).
  
  
  CONCLUSIONS
  This study compares the eradication rate of the new aerosol plasma coagulation device versus standard surgical resection of endometriosis in a rat model. Despite being a thermal method, AePC showed equality towards SR regarding eradication rate but with significantly shorter intervention time.
authors.affiliation: 1. Department of Obstetrics and Gynaecology, University of Tuebingen, Calwerstr. 7, 72076 Tuebingen, Germany (Director: Prof. D. Wallwiener);
authors.forename: Ralf
authors.initials: R
authors.lastname: Rothmund
authors.affiliation: 2. Department of Pathology, University of Tuebingen, Liebermeisterstr. 8, 72076 Tuebingen, Germany (Director: Prof. F. Fend);
authors.forename: Marcus
authors.initials: M
authors.lastname: Scharpf
authors.affiliation: 1. Department of Obstetrics and Gynaecology, University of Tuebingen, Calwerstr. 7, 72076 Tuebingen, Germany (Director: Prof. D. Wallwiener);
authors.forename: Christos
authors.initials: C
authors.lastname: Tsaousidis
authors.affiliation: 1. Department of Obstetrics and Gynaecology, University of Tuebingen, Calwerstr. 7, 72076 Tuebingen, Germany (Director: Prof. D. Wallwiener);
authors.forename: Constanze
authors.initials: C
authors.lastname: Planck
authors.affiliation: 3. Erbe Elektromedizin GmbH, Waldhoernlestr. 17, 72072 Tuebingen, Germany.
authors.forename: Markus Dominik
authors.initials: MD
authors.lastname: Enderle
authors.affiliation: 3. Erbe Elektromedizin GmbH, Waldhoernlestr. 17, 72072 Tuebingen, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Neugebauer
authors.affiliation: 3. Erbe Elektromedizin GmbH, Waldhoernlestr. 17, 72072 Tuebingen, Germany.
authors.forename: Kristin
authors.initials: K
authors.lastname: Kroeker
authors.affiliation: 3. Erbe Elektromedizin GmbH, Waldhoernlestr. 17, 72072 Tuebingen, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Nuessle
authors.affiliation: 2. Department of Pathology, University of Tuebingen, Liebermeisterstr. 8, 72076 Tuebingen, Germany (Director: Prof. F. Fend);
authors.forename: Falko
authors.initials: F
authors.lastname: Fend
authors.affiliation: 1. Department of Obstetrics and Gynaecology, University of Tuebingen, Calwerstr. 7, 72076 Tuebingen, Germany (Director: Prof. D. Wallwiener);
authors.forename: Sara
authors.initials: S
authors.lastname: Brucker
authors.affiliation: 1. Department of Obstetrics and Gynaecology, University of Tuebingen, Calwerstr. 7, 72076 Tuebingen, Germany (Director: Prof. D. Wallwiener);
authors.forename: Bernhard
authors.initials: B
authors.lastname: Kraemer
mesh_terms: D034861:Abdominal Wall; D000818:Animals; D004195:Disease Models, Animal; D004715:Endometriosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D017075:Laser Coagulation / Q000379:methods*; D011446:Prospective Studies; D011897:Random Allocation; D017208:Rats, Wistar; D016896:Treatment Outcome
keywords: aerosol plasma coagulation; endometriosis; non-contact method; rat model; thermal damage.