title: Weight loss surgery improves quality of life in pediatric patients with osteogenesis imperfecta.
abstract: BACKGROUND
  Osteogenesis imperfecta (OI) is an inherited disorder, which causes brittle bones resulting in recurrent fractures. The associated poor mobility of children with OI increases susceptibility to obesity, and obesity further dramatically limits mobility and increases fracture risk.
  
  
  OBJECTIVE
  The aim of this report is to describe outcomes of weight loss surgery (WLS) in 2 adolescents with severe obesity and OI.
  
  
  METHODS
  Two University Hospitals (in the United Kingdom and in the United States).
  
  
  METHODS
  Two cases of OI treated with WLS were identified. Pre- and postoperative anthropometric and biochemical data and clinical course were reviewed.
  
  
  RESULTS
  In these 2 cases, preoperative Body Mass Index (BMI) values were 38 and 46 kg/m2. Following laparoscopic sleeve gastrectomy (LSG), BMI decreased by 55% and 60% by 26 and 24 months, respectively. There were no surgical complications, and both patients experienced improvement in their mobility and ability to perform activities of daily living.
  
  
  CONCLUSIONS
  WLS effectively treated severe obesity in 2 OI patients and substantially improved mobility and quality of life, theoretically reducing fracture risk.
authors.affiliation: King's College Hospital, London, United Kingdom; The Hospital for Sick Children, Toronto, Canada.
authors.forename: Augusto
authors.initials: A
authors.lastname: Zani
authors.affiliation: King's College Hospital, London, United Kingdom.
authors.forename: Martha
authors.initials: M
authors.lastname: Ford-Adams
authors.affiliation: Cincinnati Children׳s Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Megan
authors.initials: M
authors.lastname: Ratcliff
authors.affiliation: South London & Maudsley Trust, London, United Kingdom.
authors.forename: Denise
authors.initials: D
authors.lastname: Bevan
authors.affiliation: Cincinnati Children׳s Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Inge
authors.affiliation: King's College Hospital, London, United Kingdom. Electronic address: ashishdesai@nhs.net.
authors.forename: Ashish
authors.initials: A
authors.lastname: Desai
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D050110:Bariatric Surgery / Q000523:psychology; D015992:Body Mass Index; D005260:Female; D005743:Gastrectomy / Q000523:psychology*; D006801:Humans; D010535:Laparoscopy / Q000523:psychology*; D008297:Male; D009767:Obesity, Morbid / Q000523:psychology / Q000601:surgery*; D010013:Osteogenesis Imperfecta / Q000523:psychology*; D063766:Pediatric Obesity / Q000523:psychology / Q000601:surgery*; D011182:Postoperative Care; D011788:Quality of Life; D016896:Treatment Outcome; D061217:Weight Reduction Programs / Q000379:methods
keywords: Brittle bone; Child; Laparoscopic; Obesity; Osteogenesis imperfecta; Pediatric; Quality of life; Sleeve gastrectomy; Weight loss surgery