title: PREDICTION OF MORPHOLOGIC DETERIORATION IN PATIENTS WITH LAMELLAR MACULAR HOLES.
abstract: OBJECTIVE
  To analyze the morphologic evolution of idiopathic lamellar macular holes (LMHs) as determined by spectral domain optical coherence tomography, and evaluate the utility of retinal function assessments through multifocal electroretinography for predicting the likelihood of morphologic deterioration in LMHs.
  
  
  METHODS
  Twenty-eight eyes of 28 patients with LMHs were examined by spectral domain optical coherence tomography at the initial visit and after 12 months. Lamellar macular holes were subdivided into morphologic deterioration (DET) and morphologic maintenance (MAI) groups based on the change in central retinal thickness during the follow-up period. Patients with LMHs were also examined by multifocal electroretinography at the initial visit. Multifocal electroretinography amplitudes were compared between DET and MAI groups, and discriminant function was calculated to predict morphologic deterioration in LMH eyes.
  
  
  RESULTS
  During the follow-up period, morphologic deterioration was found in 8 (28.6%) of LMH cases. On multifocal electroretinography, amplitudes in the central ring (R1) and first paracentral ring (R2) were significantly lower in the DET than in the MAI group. Discriminant analysis performed on these two variables yielded a discriminant function with 75% of cases classified correctly.
  
  
  CONCLUSIONS
  Multifocal electroretinography is a useful tool for predicting morphologic deterioration of LMHs. Lower multifocal electroretinography amplitudes in R1 and R2 predict an increased risk of subsequent deterioration.
authors.affiliation: Division of Vitreoretinal Surgery, Hangil Eye Hospital, Incheon, Korea.
authors.forename: Heeyoung
authors.initials: H
authors.lastname: Chung
authors.forename: Kyungmin
authors.initials: K
authors.lastname: Lee
authors.forename: Duck Jin
authors.initials: DJ
authors.lastname: Hwang
authors.forename: Youngsook
authors.initials: Y
authors.lastname: Park
authors.forename: Joonhong
authors.initials: J
authors.lastname: Sohn
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004596:Electroretinography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012167:Retinal Perforations / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology