title: The role of dopamine in modulation of Th-17 immune response in multiple sclerosis.
abstract: Neuromediators may modulate neuroinflammation, particularly in multiple sclerosis (MS). We investigated the effects of dopamine (DA) on the pro-inflammatory Th17-branch of immunity in 43 patients with relapsing-remitting MS and 20 healthy subjects. Serum DA was lower in MS relapse, whereas percentages of blood CD4(+)CD26(+)CD161(+)CD196(+) Th17-cells and production of interleukin-17 (IL-17) and interferon-gamma by anti-CD3/anti-CD28-stimulated peripheral blood mononuclear cells (PBMC) were higher in MS relapse than in remission or healthy subjects. DA suppressed IL-17 production by PBMC from MS patients and healthy subjects. The suppressive effect of DA was abolished in the presence of an antagonist of D2-like receptors (sulpiride). These data suggest an anti-inflammatory role for DA in MS.
authors.affiliation: Pirogov Russian National Research Medical University, Moscow, Russia. Electronic address: medikms@yandex.ru.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Melnikov
authors.affiliation: Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Belousova
authors.affiliation: Laboratory of Clinical Immunology, Institute of Immunology, Moscow, Russia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Murugin
authors.affiliation: Laboratory of Clinical Immunology, Institute of Immunology, Moscow, Russia.
authors.forename: Мikhail
authors.initials: М
authors.lastname: Pashenkov
authors.affiliation: Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: Alexey
authors.initials: A
authors.lastname: Boyко
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D004298:Dopamine / Q000097:blood* / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000187:drug effects*; D008297:Male; D009103:Multiple Sclerosis / Q000473:pathology*; D018709:Statistics, Nonparametric; D013469:Sulpiride / Q000494:pharmacology; D058504:Th17 Cells / Q000187:drug effects / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D018492:Dopamine Antagonists; D020381:Interleukin-17; D013469:Sulpiride; D007371:Interferon-gamma; D004298:Dopamine
keywords: Dopamine; Multiple sclerosis; Neuroimmunomodulation; Th17-cells