title: Endosomes: Emerging Platforms for Integrin-Mediated FAK Signalling.
abstract: Integrins are vital cell adhesion receptors with the ability to transmit extracellular matrix (ECM) cues to intracellular signalling pathways. ECM-integrin signalling regulates various cellular functions such as cell survival and movement. Integrin signalling has been considered to occur exclusively from adhesion sites at the plasma membrane (PM). However, recent data demonstrates integrin signalling also from endosomes. Integrin-mediated focal adhesion kinase (FAK) signalling is strongly dependent on integrin endocytosis, and endosomal FAK signalling facilitates cancer metastasis by supporting anchorage-independent growth and anoikis resistance. Here we discuss the possible mechanisms and functions of endosomal FAK signalling compared with its previously known roles in other cellular locations and discuss the potential of endosomal FAK as novel target for future cancer therapies.
authors.affiliation: Turku Centre for Biotechnology, University of Turku, FIN-20520 Turku, Finland.
authors.forename: Jonna
authors.initials: J
authors.lastname: Alanko
authors.affiliation: Turku Centre for Biotechnology, University of Turku, FIN-20520 Turku, Finland; Department of Biochemistry and Food Chemistry, University of Turku, FIN-20520 Turku, Finland. Electronic address: johanna.ivaska@utu.fi.
authors.forename: Johanna
authors.initials: J
authors.lastname: Ivaska
mesh_terms: D000818:Animals; D011992:Endosomes / Q000378:metabolism*; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy; D015398:Signal Transduction
chemical_list: D016023:Integrins; D051416:Focal Adhesion Protein-Tyrosine Kinases
keywords: Rab21; anoikis; endocytosis; focal adhesion kinase (FAK); integrin signalling; integrin traffic