title: Bilateral Refractive Changes in Vascularized Pigment Epithelial Detachment Treated by Anti-VEGF Therapy.
abstract: We report the case of a patient bilaterally treated with anti-VEGF compounds for bilateral massive vascularized retinal pigment epithelial detachment (PED). During the years prior to treatment, PED growth was accompanied by gradual hypermetropization. After right intraocular injection of bevacizumab followed by three bilateral aflibercept injections, the PED flattened resulting in a rapid relative myopization. This case illustrates ocular refractive properties associated with PED and its response to treatment. This case also highlights the importance of assessing refraction in age-related macular degeneration patients experiencing substantial PED amplitude changes.
authors.affiliation: Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem, Israel.
authors.forename: Joel
authors.initials: J
authors.lastname: Hanhart
authors.affiliation: Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Itay
authors.initials: I
authors.lastname: Chowers
keywords: Acquired vitelliform lesions; Aflibercept; Age-related macular degeneration; Bevacizumab; Hypermetropization; Myopization; Refractive changes; Retinal pigment epithelial detachment; Spectacles