title: Metabolic Syndrome and Cognitive Performance Among Chinese ≥50 Years: A Cross-Sectional Study with 3988 Participants.
abstract: BACKGROUND
  To date, the relationship between metabolic syndrome (MetS) and cognitive performance has not been well defined. This study aimed to explore the relationship between MetS and cognitive performance among Chinese elderly population.
  
  
  METHODS
  A cross-sectional study was performed, with data collected in seven clinical centers from five provinces of Northern China. All recruited participants were ≥50 years of age and complained with cognitive impairment or were reported with cognitive impairment by his/her caregiver(s). MetS was diagnosed according to the criteria issued by Chinese Medical Association Diabetes Association. Cognitive function was scored by Montreal Cognitive Assessment (MoCA).
  
  
  RESULTS
  Three thousand nine hundred eighty-eight participants (in an average of 66.4 ± 8.8 years of age, male 53.1%) were included in the analysis. Six hundred seventy-three (16.9%) participants were diagnosed with MetS, and 3013 (75.6%) participants had mild cognitive impairment (MCI) (MoCA score <26). There was no statistically significant difference in the MoCA scores between participants with MetS (21.0 ± 5.4) and without MetS (21.3 ± 5.3). In the logistic regression, after adjusting factors of age, education, marital status, smoking, and physical activity, diabetes and dyslipidemia were associated with MCI, whereas hypertension and overweight or obesity were not. Participants with diabetes had a higher risk of MCI (OR = 1.24, 95% CI: 1.03-1.50). Participants with dyslipidemia had a lower risk of MCI (OR = 0.81, 95% CI: 0.68-0.97).
  
  
  CONCLUSIONS
  In our study, MetS is not associated with cognitive performance in elderly Chinese population. However, elderly Chinese with diabetes would have lower cognition function, and the dyslipidemia might be reversely associated with the cognitive function.
authors.affiliation: 1 Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine , Beijing, China .
authors.forename: Baoxin
authors.initials: B
authors.lastname: Chen
authors.affiliation: 1 Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine , Beijing, China .
authors.forename: Xianglan
authors.initials: X
authors.lastname: Jin
authors.affiliation: 1 Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine , Beijing, China .
authors.forename: Rongjuan
authors.initials: R
authors.lastname: Guo
authors.affiliation: 1 Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine , Beijing, China .
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: 2 Wangjing Hospital of China Academy of Chinese Medical Sciences , Beijing, China .
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Hou
authors.affiliation: 1 Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine , Beijing, China .
authors.forename: Fang
authors.initials: F
authors.lastname: Gao
authors.affiliation: 1 Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine , Beijing, China .
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 1 Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine , Beijing, China .
authors.forename: Shuo
authors.initials: S
authors.lastname: Zheng
authors.affiliation: 1 Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine , Beijing, China .
authors.forename: Chen
authors.initials: C
authors.lastname: Fu
authors.affiliation: 1 Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine , Beijing, China .
authors.forename: Feiran
authors.initials: F
authors.lastname: Xue
authors.affiliation: 1 Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine , Beijing, China .
authors.forename: Huanmin
authors.initials: H
authors.lastname: Niu
authors.affiliation: 1 Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine , Beijing, China .
authors.forename: Yunling
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002681:China; D060825:Cognitive Dysfunction / Q000150:complications* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000503:physiopathology; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors; D012720:Severity of Illness Index; D012984:Software