title: Sclerotic bone lesions at abdominal magnetic resonance imaging in children with tuberous sclerosis complex.
abstract: Sclerotic bone lesions are often seen on chest CT in adults with tuberous sclerosis complex.
  
  
  
  To characterize bone lesions at abdominal MRI in children with tuberous sclerosis complex.
  
  
  
  This retrospective review included 70 children with tuberous sclerosis complex who had undergone abdominal MRI for renal imaging. An additional longitudinal study was performed in 50 children who had had two or more MRI scans. Abdominal CT (eight children) and radiographs (three children) were reviewed and compared with MRI.
  
  
  
  A total of 173 sclerotic bone lesions were detected in 51/70 children (73%; 95% confidence interval: 0.61-0.82) chiefly affecting vertebral pedicles. New lesions appeared in 20 children and growth of previous sclerotic bone lesions was documented in 14 children. Sclerotic bone lesions were more frequent in girls and in children with more extensive renal involvement.
  
  
  
  Sclerotic bone lesions are commonly detected by abdominal MRI in children with tuberous sclerosis complex. They usually affect posterior vertebral elements and their number and size increase with age. As current recommendations for tuberous sclerosis complex surveillance include renal MR performed in childhood, recognition of these lesions is useful.
authors.affiliation: Department of Neurology, Massachusetts General Hospital, 175 Cambridge Street, Suite 340, Boston, MA, USA.|Department of Pediatric Neurology, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Boronat
authors.affiliation: Department of Pediatric Radiology, Vall d' Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain.
authors.forename: Ignasi
authors.initials: I
authors.lastname: Barber
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Pargaonkar
authors.affiliation: Department of Neurology, Massachusetts General Hospital, 175 Cambridge Street, Suite 340, Boston, MA, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: Chang
authors.affiliation: Department of Neurology, Massachusetts General Hospital, 175 Cambridge Street, Suite 340, Boston, MA, USA. ethiele@partners.org.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Thiele
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging; D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012598:Sclerosis / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity; D014402:Tuberous Sclerosis / Q000000981:diagnostic imaging*
keywords: Bone; Children; Magnetic resonance imaging; Sclerotic bone lesions; Tuberous sclerosis complex