title: Preoperative Anxiety in Patients With Myasthenia Gravis and Risk for Myasthenic Crisis After Extended Transsternal Thymectomy: A CONSORT Study.
abstract: A thymectomy can ameliorate the symptoms of myasthenia gravis (MG) and prevent the progression of ocular MG (OMG) to generalized MG (GMG). However, postoperative myasthenic crisis (POMC) is a serious post-thymectomy complication. Preoperative anxiety (POA) is common but typically neglected in MG patients. The association of POA with POMC has not yet been examined.From June 2007 to December 2013, 541 cases of MG were admitted to the First Affiliated Hospital of Sun Yat-sen University (Guangzhou, China). All cases underwent extended transsternal thymectomy (ETT). The clinical and pathological characteristics of these patients, including POA and POMC, were analyzed.A total of 179 patients experienced POA and 67 patients experienced POMC. Patients with POA were more likely to have POMC, a thymoma, and an ectopic thymus. Univariate analysis showed that POMC correlated with POA, presence of an ectopic thymus, dose of pyridostigmine bromide (PYR), presence of a thymoma, MGFA stage, preoperative myasthenic crisis, and postoperative pneumonia. Multivariate logistic regression analysis showed that the independent risk factors for POMC were POA, preoperative myasthenic crisis, higher dose of PYR, and postoperative pneumonia.Our results suggest that clinicians should consider the risk factors for POMC-especially preoperative anxiety-before performing a thymectomy in patients with MG.
authors.affiliation: From the Department of Thoracic Surgery, the First Affiliated Hospital (JZ, CS, HZ, YL, HL, ZC); Lung Cancer Research Center (JZ, CS, XL, WY, HZ, YL, HL, ZC); Department of Cardiothoracic Surgery of East Division, the First Affiliated Hospital (XL, WY, ZC); Department of Neurology, the First Affiliated Hospital (WL); and Department of Thoracic Surgery, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, China (BZ).
authors.forename: Jianyong
authors.initials: J
authors.lastname: Zou
authors.forename: Chunhua
authors.initials: C
authors.lastname: Su
authors.forename: Xueping
authors.initials: X
authors.lastname: Lun
authors.forename: Weibing
authors.initials: W
authors.lastname: Liu
authors.forename: Weiling
authors.initials: W
authors.lastname: Yang
authors.forename: Beilong
authors.initials: B
authors.lastname: Zhong
authors.forename: Haoshuai
authors.initials: H
authors.lastname: Zhu
authors.forename: Yiyan
authors.initials: Y
authors.lastname: Lei
authors.forename: Honghe
authors.initials: H
authors.lastname: Luo
authors.forename: Zhenguang
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000175:diagnosis / Q000503:physiopathology; D002681:China / Q000453:epidemiology; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D011014:Pneumonia / Q000175:diagnosis / Q000209:etiology; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D011729:Pyridostigmine Bromide / Q000008:administration & dosage*; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013934:Thymectomy / Q000009:adverse effects / Q000379:methods / Q000523:psychology; D013945:Thymoma / Q000150:complications / Q000601:surgery*
chemical_list: D002800:Cholinesterase Inhibitors; D011729:Pyridostigmine Bromide