title: T-cell Lymphomas: Updates in Biology and Diagnosis.
abstract: Nodal-based peripheral T-cell lymphomas are heterogeneous malignancies with overlapping morphology and clinical features. However, the current World Health Organization classification scheme separates these tumors into prognostically relevant categories. Since its publication, efforts to uncover the gene expression profiles and molecular alterations have subdivided these categories further, and distinct subgroups are emerging with specific profiles that reflect the cell of origin for these tumors and their microenvironment. Identification of the perturbed biologic pathways may prove useful in selecting patients for specific therapies and associating biomarkers with survival and relapse.
authors.affiliation: Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, L-30, Cleveland, OH 44195, USA.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Ondrejka
authors.affiliation: Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, L-30, Cleveland, OH 44195, USA. Electronic address: hsie@ccf.org.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Hsi
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000175:diagnosis / Q000235:genetics; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000235:genetics; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000235:genetics; D009154:Mutation
chemical_list: D014408:Biomarkers, Tumor
keywords: Anaplastic large cell lymphoma; Angioimmunoblastic T-cell lymphoma; Nodal; Non-Hodgkin lymphoma; Pathobiology; Peripheral T-cell lymphoma; T-cell lymphoma; T-cell lymphoma subtypes; T-follicular helper cells