title: A prospective comparison of perioperative morbidity in advanced epithelial ovarian cancer: Primary versus interval cytoreduction - experience from India.
abstract: OBJECTIVE
  The objective was to compare perioperative morbidity and mortality of patients with advanced epithelial ovarian cancer (EOC) treated with either of the two treatment approaches; neoadjuvant chemotherapy (NACT) followed by interval debulking versus upfront surgery.
  
  
  METHODS
  Prospective comparative observational study.
  
  
  METHODS
  In total, 51 patients were included in the study. All patients with diagnosed advanced EOC (International Federation of Gynecology and Obstetrics IIIC and IV) presenting for the 1(st) time were included in the study.
  
  
  METHODS
  Patients were either operated upfront (n = 19) if deemed operable or were subjected to NACT followed by interval debulking (n = 32).
  
  
  METHODS
  Intra- and postoperative morbidity and mortality were the primary outcome measures.
  
  
  RESULTS
  Patients with interval cytoreduction were noted to have significantly lesser operative time, blood loss, and extent of surgery. Their discharge time was also significantly earlier. However, they did not differ from the other group vis. a vis. postoperative complications or mortality.
  
  
  CONCLUSIONS
  Neoadjuvant chemotherapy although has a positive impact on various intraoperative adverse events, fails to show any impact on immediate postoperative negative outcomes.
authors.affiliation: Department of Surgical Oncology, Sheri-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
authors.forename: Sheikh Zahoor
authors.initials: SZ
authors.lastname: Ahmad
authors.affiliation: Department of Gynecologic Oncology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
authors.forename: Anupama
authors.initials: A
authors.lastname: Rajanbabu
authors.affiliation: Department of Surgical Oncology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
authors.forename: D K
authors.initials: DK
authors.lastname: Vijaykumar
authors.affiliation: Department of Surgical Oncology, Sheri-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
authors.forename: Altaf Gauhar
authors.initials: AG
authors.lastname: Haji
authors.affiliation: Department of Medical Oncology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
authors.forename: K
authors.initials: K
authors.lastname: Pavithran
keywords: Epithelial ovarian cancer; interval surgery; postoperative morbidity; primary surgery