title: Recurrent Episodes of Stroke-Like Symptoms in a Patient with Charcot-Marie-Tooth Neuropathy X Type 1.
abstract: Charcot-Marie-Tooth disease (CMT), also known as hereditary motor sensory neuropathy, is a heterogeneous group of disorders best known for causing inherited forms of peripheral neuropathy. The X-linked form, CMTX1, is caused by mutations in the gap junction protein beta 1 (GJB1) gene, expressed both by peripheral Schwann cells and central oligodendrocytes. Central manifestations are known but are rare, and there are few case reports of leukoencephalopathy with transient or persistent neurological deficits in patients with this CMT subtype. Here, we report the case of a man with multiple male and female family members affected by neuropathy who carries a pathologic mutation in GJB1. He has experienced three transient episodes with variable neurological deficits over the course of 7 years with corresponding changes on magnetic resonance imaging (MRI). This case illustrates CMT1X as a rare cause of transient neurological deficit and demonstrates the evolution of associated reversible abnormalities on MRI over time. To the best of our knowledge, this report provides the longest period of serial imaging in a single patient with this condition in the English language literature.
authors.affiliation: Departments of Neurology, Pennsylvania State Milton S. Hershey Medical Center, Pennsylvania State College of Medicine, Hershey, Pa., USA.
authors.forename: Ning
authors.initials: N
authors.lastname: Wu
authors.affiliation: Departments of Neurology, Pennsylvania State Milton S. Hershey Medical Center, Pennsylvania State College of Medicine, Hershey, Pa., USA.
authors.forename: Sarita
authors.initials: S
authors.lastname: Said
authors.affiliation: Departments of Radiology, Pennsylvania State Milton S. Hershey Medical Center, Pennsylvania State College of Medicine, Hershey, Pa., USA.
authors.forename: Shyamsunder
authors.initials: S
authors.lastname: Sabat
authors.affiliation: Departments of Neurology, Pennsylvania State Milton S. Hershey Medical Center, Pennsylvania State College of Medicine, Hershey, Pa., USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Wicklund
authors.affiliation: Departments of Neurology, Pennsylvania State Milton S. Hershey Medical Center, Pennsylvania State College of Medicine, Hershey, Pa., USA; Departments of Neural and Behavioral Sciences, Pennsylvania State Milton S. Hershey Medical Center, Pennsylvania State College of Medicine, Hershey, Pa., USA.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Stahl
keywords: CMTX1; Charcot-Marie-Tooth disease; Hereditary motor sensory neuropathy; Magnetic resonance imaging; Transient neurological symptoms