title: New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence.
abstract: Pathogenicity islands (PAIs) are regions of the chromosome of pathogenic bacteria that harbor virulence genes, which were probably acquired by lateral gene transfer. Several PAIs can excise from the bacterial chromosome by site-specific recombination and in this review have been denominated "excisable PAIs". Here, the characteristic of some of the excisable PAIs from Salmonella enterica and the possible role and impact of the excision process on bacterial virulence is discussed. Understanding the role of PAI excision could provide important insights relative to the emergence, evolution and virulence of pathogenic enterobacteria.
authors.affiliation: Millennium Institute on Immunology and Immunoterapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Nieto
authors.affiliation: Millennium Institute on Immunology and Immunoterapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Catalina
authors.initials: C
authors.lastname: Pardo-Roa
authors.affiliation: Millennium Institute on Immunology and Immunoterapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Salazar-Echegarai
authors.affiliation: Millennium Institute on Immunology and Immunoterapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Hugo E
authors.initials: HE
authors.lastname: Tobar
authors.affiliation: Millennium Institute on Immunology and Immunoterapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Irenice
authors.initials: I
authors.lastname: Coronado-Arrázola
authors.affiliation: Millennium Institute on Immunology and Immunotherapy, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas y Facultad de Medicina, Universidad Andrés Bello, Santiago, Chile.
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Riedel
authors.affiliation: Millennium Institute on Immunology and Immunoterapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile; Departamento de Endocrinología, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile, Santiago 8330024, Chile; INSERM UMR1064, 44000, Nantes, France.
authors.forename: Alexis M
authors.initials: AM
authors.lastname: Kalergis
authors.affiliation: Millennium Institute on Immunology and Immunoterapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile; INSERM UMR1064, 44000, Nantes, France. Electronic address: sbueno@bio.puc.cl.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Bueno
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D044404:Genomic Islands; D006801:Humans; D020071:Interspersed Repetitive Sequences; D011995:Recombination, Genetic; D012480:Salmonella Infections / Q000382:microbiology; D019779:Salmonella enterica / Q000235:genetics* / Q000472:pathogenicity*; D014774:Virulence
keywords: Excision; Pathogenicity island; Salmonella; Virulence