title: Colchicum autumnale in Patients with Goitre with Euthyroidism or Mild Hyperthyroidism: Indications for a Therapeutic Regulative Effect-Results of an Observational Study.
abstract: Introduction. Goitre with euthyroid function or with subclinical or mild hyperthyroidism due to thyroid autonomy is common. In anthroposophic medicine various thyroid disorders are treated with Colchicum autumnale (CAU). We examined the effects of CAU in patients with goitre of both functional states. Patients and methods. In an observational study, 24 patients with goitre having suppressed thyroid stimulating hormone (TSH) levels with normal or slightly elevated free thyroxine (fT4) and free triiodothyronine (fT3) (group 1, n = 12) or normal TSH, fT3, and fT4 (group 2, n = 12) were included. After 3 months and after 6 to 12 months of CAU treatment, we investigated clinical pathology using the Hyperthyroid Symptom Scale (HSS), hormone status (TSH, fT4, and fT3), and thyroidal volume (tV). Results. After treatment with CAU, in group 1 the median HSS decreased from 4.5 (2.3-11.8) to 2 (1.3-3) (p < 0.01) and fT3 decreased from 3.85 (3.5-4.78) to 3.45 (3.3-3.78) pg/mL (p < 0.05). In group 2 tV (13.9% (18.5%-6.1%)) and TSH (p < 0.01) were reduced. Linear regression for TSH and fT3 in both groups indicated a regulative therapeutic effect of CAU. Conclusions. CAU positively changed the clinical pathology of subclinical hyperthyroidism and thyroidal volume in patients with euthyroid goitre by normalization of the regulation of thyroidal hormones.
authors.affiliation: Integrated Curriculum for Anthroposophic Medicine, Institute for Integrative Medicine, Faculty for Health, Department for Medicine, Alfred-Herrhausen-Straße 50, 58448 Witten, Germany; Gemeinschaftskrankenhaus Herdecke, Department for Internal Medicine, Gerhard-Kienle-Weg 4, 58313 Herdecke, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Scheffer
authors.affiliation: Research Institute Havelhöhe, Kladower Damm 221, 14089 Berlin, Germany; Department of Internal Medicine, Havelhöhe Hospital, Kladower Damm 221, 14089 Berlin, Germany.
authors.forename: Marion
authors.initials: M
authors.lastname: Debus
authors.affiliation: Institute for Integrative Medicine, Faculty for Health, Department for Medicine, University of Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58448 Witten, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Heckmann
authors.affiliation: Integrated Curriculum for Anthroposophic Medicine, Institute for Integrative Medicine, Faculty for Health, Department for Medicine, Alfred-Herrhausen-Straße 50, 58448 Witten, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Cysarz
authors.affiliation: Research Institute Havelhöhe, Kladower Damm 221, 14089 Berlin, Germany; Department of Internal Medicine, Havelhöhe Hospital, Kladower Damm 221, 14089 Berlin, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Girke