title: A potent antibacterial indole alkaloid from Psychotria pilifera.
abstract: A new strychnine alkaloid, 16,17,19,20-tetrahydro-2,16-dehydro-18-deoxyisostrychnine (1), and fourteen known alkaloids were isolated from the leaves of Psychotria pilifera. Their structures were identified on the basis of extensive spectroscopic analysis, as well as by comparison with the reported spectroscopic data. The new alkaloid (1) exhibited potent antibacterial activity against Escherichia coli, equivalent to cefotaxime with MIC value of 0.781 μg/ml.
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.|c University of Chinese Academy of Sciences , Beijing 100049 , China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Chang-Wei
authors.initials: CW
authors.lastname: Song
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.|b Department of Chemistry , COMSATS Institute of Information Technology , Abbottabad 22060 , Pakistan.
authors.forename: Afsar
authors.initials: A
authors.lastname: Khan
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Xing-Wei
authors.initials: XW
authors.lastname: Yang
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Gui-Guang
authors.initials: GG
authors.lastname: Cheng
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Luo
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D032069:Psychotria / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013331:Strychnine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C000613172:16,17,19,20-tetrahydro-2,16-dehydro-18-deoxyisostrychnine; D000900:Anti-Bacterial Agents; D013331:Strychnine
keywords: 16,17,19,20–tetrahydro–2,16–dehydro–18–deoxyisostrychnine; Psychotria pilifera; Rubiaceae; antibacterial activity; indole alkaloid