title: Hepatocellular carcinoma and non-alcoholic steatohepatitis: The state of play.
abstract: Hepatocellular carcinoma (HCC) is now the fifth cancer of greatest frequency and the second leading cause of cancer related deaths worldwide. Chief amongst the risks of HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesity. The latter can promote non-alcoholic fatty liver disease (NAFLD), that can lead to the inflammatory form non-alcoholic steatohepatitis (NASH), and can in turn promote HCC. The mechanisms by which NASH promotes HCC are only beginning to be characterized. Here in this review, we give a summary of the recent findings that describe and associate NAFLD and NASH with the subsequent HCC progression. We will focus our discussion on clinical and genomic associations that describe new risks for NAFLD and NASH promoted HCC. In addition, we will consider novel murine models that clarify some of the mechanisms that drive NASH HCC formation.
authors.affiliation: Bérénice Charrez, Lionel Hebbard, Department of Molecular and Cell Biology, James Cook University, Townsville, QLD 4811, Australia.
authors.forename: Bérénice
authors.initials: B
authors.lastname: Charrez
authors.affiliation: Bérénice Charrez, Lionel Hebbard, Department of Molecular and Cell Biology, James Cook University, Townsville, QLD 4811, Australia.
authors.forename: Liang
authors.initials: L
authors.lastname: Qiao
authors.affiliation: Bérénice Charrez, Lionel Hebbard, Department of Molecular and Cell Biology, James Cook University, Townsville, QLD 4811, Australia.
authors.forename: Lionel
authors.initials: L
authors.lastname: Hebbard
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008113:Liver Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D014408:Biomarkers, Tumor
keywords: Hepatocellular carcinoma; Mice; Models; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis