title: Olaparib for the treatment of ovarian cancer.
abstract: Olaparib, an oral poly(ADP-ribose) polymerase (PARP) inhibitor, is the first FDA-approved drug in its class for patients with ovarian cancer, specifically in a subset of patients with BRCA mutations and prior chemotherapy treatments. PARP inhibitors have had other implications in different solid tumor types including breast, gastric and pancreatic malignancies. In light of the recent FDA approval of olaparib for the treatment of ovarian cancer, this article aims to outline the mechanisms and implications of the drug. With a favorable adverse event profile and improved outcomes, including progression-free survival, olaparib has demonstrated augmentation to therapeutic options in the treatment of ovarian cancer.
authors.affiliation: Department of Internal Medicine, Division of Hematology and Oncology, University of Colorado Cancer Center, Aurora, Colorado, USA. ethan.bornstein@ucdenver.edu.
authors.forename: E
authors.initials: E
authors.lastname: Bornstein
authors.affiliation: Department of Internal Medicine, Division of Hematology and Oncology, University of Colorado Cancer Center, Aurora, Colorado, USA. antonio.jimeno@UCDenver.edu.
authors.forename: A
authors.initials: A
authors.lastname: Jimeno
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D010793:Phthalazines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D010879:Piperazines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D010793:Phthalazines; D010879:Piperazines; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; C531550:olaparib
keywords: Olaparib; Ovarian cancer; PARP inhibitor