title: Schwannoma in Sellar Region Mimics Invasive Pituitary Macroadenoma: Literature Review With One Case Report.
abstract: In central nervous system, schwannomas, as ubiquitous tumors, mostly originate from sensory nerves like auditory and trigeminal nerves. However, intrasellar schwannomas are extremely rare. They are often misdiagnosed as pituitary adenomas. We report a rare case of schwannoma in the sellar region--a challenging diagnosis guided by clinical presentations, radiological signs, and postoperative pathological test. We represent a 65-year-old woman who had suffered from headaches, hypothyroidism, and visual disturbance. Her MRI revealed an abnormal sellar region mixed-signal mass lesion with suprasellar, left parasellar, and sellar floor invasiveness. We present detailed analysis of the patient's disease course and review relevant literatures. Written informed consent was obtained from the patient for publication of this article. A copy of the written consent is available for review by the editors of MEDICINE. Because this article does not involve any human or animal trials, there is no need to conduct special ethic review and the ethical approval is not necessary. When surgically treated, her specimen revealed a typical histopathology pattern of schwannoma. The patient's symptoms improved a lot after surgery and he continues to be under observation. Despite its rarity, intrasellar schwannoma should be considered in the differential diagnosis of sellar lesions that mimic pituitary adenomas.
authors.affiliation: From the Department of Neurosurgery (XK, WM, YL, YY, BX, JW, YY, JG, WL, ZX, WD, ZR, CS, RW); Department of Pathology (HW), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Xiangyi
authors.initials: X
authors.lastname: Kong
authors.forename: Huanwen
authors.initials: H
authors.lastname: Wu
authors.forename: Wenbin
authors.initials: W
authors.lastname: Ma
authors.forename: Yongning
authors.initials: Y
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Bing
authors.initials: B
authors.lastname: Xing
authors.forename: Junji
authors.initials: J
authors.lastname: Wei
authors.forename: Yong
authors.initials: Y
authors.lastname: Yao
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Lian
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Xu
authors.forename: Wanchen
authors.initials: W
authors.lastname: Dou
authors.forename: Zuyuan
authors.initials: Z
authors.lastname: Ren
authors.forename: Changbao
authors.initials: C
authors.lastname: Su
authors.forename: Renzhi
authors.initials: R
authors.lastname: Wang
mesh_terms: D000236:Adenoma / Q000175:diagnosis*; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009442:Neurilemmoma / Q000175:diagnosis* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000175:diagnosis*; D012658:Sella Turcica