title: Chemotherapy for intraperitoneal use: a review of hyperthermic intraperitoneal chemotherapy and early post-operative intraperitoneal chemotherapy.
abstract: Peritoneal spread of tumors is a major problem in cancer management. Patients develop a marked deterioration in quality of life and shortened survival. This is in part due to bowel obstructions, marked ascites, and overall increase debilitation. Standard medical management has shown to be inadequate for the treatment of these problems. Surgery can palliate symptoms, however, it is unable to be complete at the microscopic level by a significant spillage of tumor cells throughout the abdomen. Chemotherapy can have some improvement in symptoms however it is short lived due to poor penetration into the peritoneal cavity. The role of intraperitoneal chemotherapy is to maximize tumor penetration and optimize cell death while minimizing systemic toxicity. Hyperthermic intraperitoneal chemotherapy (HIPEC) and early post-operative intraperitoneal chemotherapy (EPIC) are two treatment methods that serve this role and have been shown to improve survival. This review will discuss different chemotherapies used for both of these treatment options.
authors.affiliation: 1 Department of Surgery, 2 Department of Medical Oncology, Tufts Medical Center, Boston, MA, USA.
authors.forename: Martin D
authors.initials: MD
authors.lastname: Goodman
authors.affiliation: 1 Department of Surgery, 2 Department of Medical Oncology, Tufts Medical Center, Boston, MA, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: McPartland
authors.affiliation: 1 Department of Surgery, 2 Department of Medical Oncology, Tufts Medical Center, Boston, MA, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Detelich
authors.affiliation: 1 Department of Surgery, 2 Department of Medical Oncology, Tufts Medical Center, Boston, MA, USA.
authors.forename: Muhammad Wasif
authors.initials: MW
authors.lastname: Saif
keywords: Intraperitoneal chemotherapy; early post-operative intraperitoneal chemotherapy (EPIC); hyperthermic intraperitoneal chemotherapy (HIPEC)