title: Oral bioavailability of curcumin: problems and advancements.
abstract: Curcumin is a natural compound of Curcuma longa L. and has shown many pharmacological activities such as anti-inﬂammatory, anti-oxidant in both preclinical and clinical studies. Moreover, curcumin has hepatoprotective, neuroprotective activities and protects against myocardial infarction. Particularly, curcumin has also demonstrated favorite anticancer efficacy. But limiting factors such as its extremely low oral bioavailability hampers its application as therapeutic agent. Therefore, many technologies have been developed and applied to overcome this limitation. This review described the main physicochemical properties of curcumin and summarized the recent studies in the design and development of oral delivery systems for curcumin to enhance the solubility and oral bioavailability, including liposomes, nanoparticles and polymeric micelles, phospholipid complexes, and microemulsions.
authors.affiliation: a Department of Pharmacy , Linyi People's Hospital Affiliated to Shandong University , Linyi , China ;
authors.forename: Weidong
authors.initials: W
authors.lastname: Liu
authors.affiliation: b Department of Pharmaceutics, College of Pharmacy , Shandong University , Jinan , China ;
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Zhai
authors.affiliation: c Department of Clinical Medicine , Linyi People's Hospital Affiliated to Shandong University , Linyi , China.
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Heng
authors.affiliation: c Department of Clinical Medicine , Linyi People's Hospital Affiliated to Shandong University , Linyi , China.
authors.forename: Feng Yuan
authors.initials: FY
authors.lastname: Che
authors.affiliation: c Department of Clinical Medicine , Linyi People's Hospital Affiliated to Shandong University , Linyi , China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Chen
authors.affiliation: c Department of Clinical Medicine , Linyi People's Hospital Affiliated to Shandong University , Linyi , China.
authors.forename: Dezhong
authors.initials: D
authors.lastname: Sun
authors.affiliation: b Department of Pharmaceutics, College of Pharmacy , Shandong University , Jinan , China ;
authors.forename: Guangxi
authors.initials: G
authors.lastname: Zhai
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001682:Biological Availability; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions; D006801:Humans; D008081:Liposomes; D008823:Micelles; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D065568:Oral Mucosal Absorption
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D004655:Emulsions; D008081:Liposomes; D008823:Micelles; D003474:Curcumin
keywords: Curcumin; liposomes; nanoparticles; oral bioavailability