title: Current status and future directions of T-lymphoblastic lymphoma in children and adolescents.
abstract: The main challenges in the treatment of T-cell lymphoblastic lymphoma (T-LBL) in children and adolescents are twofold: to increase survival rates in concert with reduction of acute and long-term toxicities including the rate of secondary malignancies. The need for molecular and prognostic markers in T-LBL is crucial to allow for systematic treatment optimization and may serve as targets for new treatment approaches.
authors.affiliation: Paediatric Haematology and Oncology, University Hospital Muenster, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Burkhardt
authors.affiliation: Paediatric Haematology and Oncology, University Hospital Muenster, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Mueller
authors.affiliation: Paediatric Haematology and Oncology, University Hospital Muenster, Germany.
authors.forename: Tasneem
authors.initials: T
authors.lastname: Khanam
authors.affiliation: Department of Pathology, University of Utah Health Sciences Center, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah.
authors.forename: Sherrie L
authors.initials: SL
authors.lastname: Perkins
mesh_terms: D000293:Adolescent; D002648:Child; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000628:therapy*; D058990:Molecular Targeted Therapy / Q000379:methods; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000628:therapy*
keywords: Paediatric T-lymphoblastic lymphoma; genetic classifier; molecular markers; risk group stratification; treatment