title: Streptococcal Infection-related Nephritis (SIRN) Manifesting Membranoproliferative Glomerulonephritis Type I.
abstract: We herein report the case of an 18-year-old boy who developed nephrotic syndrome and hypertension after upper airway inflammation. Post-streptococcal acute glomerulonephritis was diagnosed on the basis of a high antistreptolysin O titer, hypocomplementemia, proteinuria, and microscopic hematuria. A renal biopsy was performed due to persistent proteinuria, and the pathological diagnosis was membranoproliferative glomerulonephritis (MPGN) type I. Glomeruli showed positive staining for nephritis-associated plasmin receptor (NAPlr), a nephritogenic group A streptococcal antigen, and plasmin activity was found in a similar distribution as NAPlr deposition. This rare case of streptococcal infection-related nephritis (SIRN) manifesting MPGN type I supports the histological diversity of SIRN.
authors.affiliation: Division of Nephrology, Department of Medicine, Showa University School of Medicine, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Iseri
authors.forename: Masayuki
authors.initials: M
authors.lastname: Iyoda
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Naoto
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Oda
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Takanori
authors.initials: T
authors.lastname: Shibata
mesh_terms: D000293:Adolescent; D000942:Antigens, Bacterial / Q000302:isolation & purification; D001706:Biopsy; D004487:Edema / Q000209:etiology; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis* / Q000382:microbiology*; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007678:Kidney Glomerulus / Q000382:microbiology* / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000175:diagnosis* / Q000382:microbiology*; D011507:Proteinuria / Q000209:etiology; D011956:Receptors, Cell Surface / Q000302:isolation & purification; D012075:Remission, Spontaneous; D013290:Streptococcal Infections / Q000150:complications* / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000276:immunology / Q000302:isolation & purification*; D015430:Weight Gain
chemical_list: D000942:Antigens, Bacterial; D011956:Receptors, Cell Surface; C517776:nephritis-associated plasminogen receptor, Streptococcus