title: Therapy region monitoring based on PET using 478 keV single prompt gamma ray during BNCT: A Monte Carlo simulation study.
abstract: We confirmed the feasibility of using our proposed system to extract two different kinds of functional images from a positron emission tomography (PET) module by using an insertable collimator during boron neutron capture therapy (BNCT). Coincidence events from a tumor region that included boron particles were identified by a PET scanner before BNCT; subsequently, the prompt gamma ray events from the same tumor region were collected after exposure to an external neutron beam through an insertable collimator on the PET detector. Five tumor regions that contained boron particles and were located in the water phantom and in the BNCT system with the PET module were simulated with Monte Carlo simulation code. The acquired images were quantitatively analyzed. Based on the receiver operating characteristic (ROC) curves in the five boron regions, A, B, C, D, and E, the PET and single-photon images were 10.2%, 11.7%, 8.2% (center region), 12.6%, and 10.5%, respectively. We were able to acquire simultaneously PET and single prompt photon images for tumor regions monitoring by using an insertable collimator without any additional isotopes.
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul 505, Republic of Korea.
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Jung
authors.affiliation: Department of Radiation Oncology, University of Florida, Gainesville, FL 32610-0385, United States.
authors.forename: Bo
authors.initials: B
authors.lastname: Lu
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul 505, Republic of Korea.
authors.forename: Do-Kun
authors.initials: DK
authors.lastname: Yoon
authors.affiliation: Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, United States.
authors.forename: Key Jo
authors.initials: KJ
authors.lastname: Hong
authors.affiliation: Department of Radiation Oncology, College of Medicine, Seoul St. Mary's Hospital, Catholic University of Korea, Seoul 505, Republic of Korea.
authors.forename: HongSeok
authors.initials: H
authors.lastname: Jang
authors.affiliation: Department of Radiation Oncology, University of Florida, Gainesville, FL 32610-0385, United States.
authors.forename: Chihray
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul 505, Republic of Korea. Electronic address: suhsanta@catholic.ac.kr.
authors.forename: Tae Suk
authors.initials: TS
authors.lastname: Suh
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000379:methods*; D003198:Computer Simulation; D005720:Gamma Rays; D006801:Humans; D009010:Monte Carlo Method; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D049268:Positron-Emission Tomography / Q000379:methods*
keywords: Insertable collimator; PET; Prompt gamma ray; Tumor region