title: Impact of dermatologic adverse events induced by targeted therapies on quality of life.
abstract: BACKGROUND
  Investigations about the impact of dermatologic adverse events on quality of life in the context of targeted therapies are quite recent and results vary in some dimensions. This article aims to summarize the existing data and to clarify needs in terms of clinical management and future research.
  
  
  METHODS
  A literature review was done with Pubmed, Medline, Scopus and PsycInfo databases and it combined the empirical studies published in English and in French over the past ten years.
  
  
  CONCLUSIONS
  Dermatologic adverse events globally have a low to moderate impact on quality of life, mainly in the physical and emotional domains. Reasons for inter-individual variations in adjustment and long-term impact are still not well known. Making quality of life assessments systematic, making early referrals of patients to dermatology consultations and giving more attention to individual experience were identified as measures that could help prevent deterioration in quality of life.
authors.affiliation: Psycho-Oncology Unit, Gustave Roussy, Villejuif, France; Laboratory of Psychopathology and Health Processes, EA 4057, Psychology Institute, Paris Descartes University-Sorbonne Paris Cité, Boulogne-Billancourt, France. Electronic address: cecile.charles@gustaveroussy.fr.
authors.forename: Cécile
authors.initials: C
authors.lastname: Charles
authors.affiliation: Laboratory of Psychopathology and Health Processes, EA 4057, Psychology Institute, Paris Descartes University-Sorbonne Paris Cité, Boulogne-Billancourt, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Bungener
authors.affiliation: Psychosomatic and Psycho-Oncology Research Unit, University of Brussels-Psycho-Oncology Clinic, Jules Bordet Institute, Brussels, Belgium.
authors.forename: Darius
authors.initials: D
authors.lastname: Razavi
authors.affiliation: Dermatology Service, Gustave Roussy Cancer Campus Grand-Paris-Sud, Villejuif, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Mateus
authors.affiliation: Dermatology Service, Gustave Roussy Cancer Campus Grand-Paris-Sud, Villejuif, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Routier
authors.affiliation: Department of Biostatistics and Epidemiology, Gustave Roussy, Villejuif, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Lanoy
authors.affiliation: Department of Research and Innovation, L'Oreal, Paris, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Verschoore
authors.affiliation: Dermatology Service, Gustave Roussy Cancer Campus Grand-Paris-Sud, Villejuif, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Robert
authors.affiliation: Psycho-Oncology Unit, Gustave Roussy, Villejuif, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Dauchy
mesh_terms: D006801:Humans; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D011788:Quality of Life; D012871:Skin Diseases / Q000139:chemically induced
keywords: Dermatologic adverse events; Quality of life; Targeted therapies