title: Serum and Urinary Orosomucoid in Young Patients With Type 1 Diabetes: A Link Between Inflammation, Microvascular Complications, and Subclinical Atherosclerosis.
abstract: Orosomucoid is an acute-phase serum protein that is upregulated in urine samples of patients with diabetic nephropathy. We assessed serum and urinary orosomucoid levels in children and adolescents with type 1 diabetes and their relation to microvascular complications and carotid intima-media thickness (CIMT). Sixty patients with type 1 diabetes were divided into 2 groups according to the presence of microvascular complications and compared with 60 healthy controls. High-sensitivity C-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), urinary albumin-creatinine ratio (UACR), serum and urinary orosomucoid, and CIMT were assessed. Both serum and urinary orosomucoid levels were significantly increased in patients with and without microvascular complications compared with controls, and the highest levels were in patients with complications (P < .001). Serum and urinary orosomucoid were higher in patients with microalbuminuria than normoalbuminuric group (P < .001). The cutoff value of urinary orosomucoid at 2825 ng/mL could differentiate patients with and without microvascular complications. Serum and urinary orosomucoid were positively correlated. Multiple regression analysis showed that HbA1c, UACR, hs-CRP, and CIMT were independently related to orosomucoid. We suggest that orosomucoid is a significant independent factor for diabetic microvascular complications and can be considered as an early marker of renal injury. High orosomucoid levels in type 1 diabetes reflect endothelial dysfunction and subclinical atherosclerosis.
authors.affiliation: Department of Pediatrics, Ain Shams University, Cairo, Egypt.
authors.forename: Nagham M S
authors.initials: NM
authors.lastname: El-Beblawy
authors.affiliation: Department of Pediatrics, Ain Shams University, Cairo, Egypt.
authors.forename: Nevine G
authors.initials: NG
authors.lastname: Andrawes
authors.affiliation: Department of Clinical Pathology, Ain Shams University, Cairo, Egypt eman.ismail_70@yahoo.com.
authors.forename: Eman Abdel Rahman
authors.initials: EA
authors.lastname: Ismail
authors.affiliation: Department of Cardiology, Ain Shams University, Cairo, Egypt.
authors.forename: Basem El-Said
authors.initials: BE
authors.lastname: Enany
authors.affiliation: Department of Pediatrics, Ain Shams University, Cairo, Egypt.
authors.forename: Heba S Abou
authors.initials: HS
authors.lastname: El-Seoud
authors.affiliation: Department of Pediatrics, Ain Shams University, Cairo, Egypt.
authors.forename: Marwa A
authors.initials: MA
authors.lastname: Erfan
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis / Q000097:blood / Q000652:urine; D015415:Biomarkers / Q000097:blood*; D059168:Carotid Intima-Media Thickness; D002648:Child; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000652:urine*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000652:urine; D008297:Male; D009961:Orosomucoid / Q000378:metabolism* / Q000652:urine
chemical_list: D015415:Biomarkers; D009961:Orosomucoid
keywords: carotid intima–media thickness; microvascular complications; orosomucoid; type 1 diabetes