title: Peptide based hydrogels for cancer drug release: modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating d-amino acid residue(s).
abstract: Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels have been successfully modulated by incorporating d-amino acid residues, indicating their potential use for drug delivery in the future.
authors.affiliation: Department of Biological Chemistry, Indian Association for The Cultivation of Science, Jadavpur, Kolkata, 700032, India. bcab@iacs.res.in.
authors.forename: Kingshuk
authors.initials: K
authors.lastname: Basu
authors.forename: Abhishek
authors.initials: A
authors.lastname: Baral
authors.forename: Shibaji
authors.initials: S
authors.lastname: Basak
authors.forename: Ashkan
authors.initials: A
authors.lastname: Dehsorkhi
authors.forename: Jayanta
authors.initials: J
authors.lastname: Nanda
authors.forename: Debmalya
authors.initials: D
authors.lastname: Bhunia
authors.forename: Surajit
authors.initials: S
authors.lastname: Ghosh
authors.forename: Valeria
authors.initials: V
authors.lastname: Castelletto
authors.forename: Ian W
authors.initials: IW
authors.lastname: Hamley
authors.forename: Arindam
authors.initials: A
authors.lastname: Banerjee
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002470:Cell Survival; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation / Q000187:drug effects*; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D061986:MCF-7 Cells; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D010455:Peptides / Q000737:chemistry*; D059748:Proteolysis
chemical_list: D000596:Amino Acids; D000970:Antineoplastic Agents; D004337:Drug Carriers; D020100:Hydrogels; D010455:Peptides