title: The role of adipose tissue and adipokines in the manifestation of type 2 diabetes in the long-term period following myocardial infarction.
abstract: BACKGROUND
  This study aimed to evaluate the markers of insulin resistance and adipokine status in patients with visceral obesity during hospitalization following myocardial infarction (MI) and assess the disturbances of carbohydrate metabolism present 1 year after MI onset.
  
  
  METHODS
  94 male patients with MI were recruited. The exclusion criteria were as follows: age less than 50 or greater than 80 years, the presence of type 2 diabetes mellitus (T2DM), and a prior history of pronounced renal failure.Obesity types were defined according to body mass index (BMI), waist circumference (WC) and visceral adipose tissue (VAT) area. Glucose, insulin, adiponectin, leptin, and insulin resistance (IR) index were measured on days 1 and 12 after the onset of MI. New-onset type 2 diabetes was assessed 1 year after MI onset.
  
  
  RESULTS
  According to computed tomography assessments of all study patients, 69 % of patients with MI suffered from visceral obesity. The VAT area was more closely associated with the risk of developing type 2 diabetes compared with the obesity parameters, BMI and WC. Patients with a VAT area greater than 130 cm(2) had a 3.6-fold higher risk of developing type 2 diabetes. The presence of IR and hyperleptinemia increased the risk of developing diabetes in the post-MI period 3.5 and 3.7 times, respectively, in patients with visceral obesity compared with patients without visceral obesity.
  
  
  CONCLUSIONS
  Visceral obesity is associated with IR, a 5.7-fold increase in leptin levels and a high risk of developing type 2 diabetes 1 year after MI onset.
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Barbarash
authors.affiliation: Laboratory of Research Homeostasis, Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Gruzdeva
authors.affiliation: Laboratory of Research Homeostasis, Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Evgenya
authors.initials: E
authors.lastname: Uchasova
authors.affiliation: Laboratory of Research Homeostasis, Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Dyleva
authors.affiliation: Laboratory of Research Homeostasis, Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Belik
authors.affiliation: Department of Biochemistry and Molecular Biology, State Budget Educational Institution of Higher Professional Education "Siberian State Medical University" of the Russian Federation Ministry of Health, Tomsk, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Akbasheva
authors.affiliation: Laboratory of Blood Circulation Pathology, Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Victoria
authors.initials: V
authors.lastname: Karetnikova
authors.affiliation: Laboratory and X-ray tomographic diagnosis, Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kokov
keywords: Adipokines; Adipose tissue; Carbohydrate metabolism disorders; Diabetes; Inflammation percutaneous coronary intervention; Insulin resistance; Myocardial infarction