title: [Does consumption of tobacco, alcohol, and cannabis in adolescents and young adults with cancer affect the use of analgesics during hospitalizations?].
abstract: BACKGROUND
  The specificities of adolescents and young adults (AYAs) aged 15-25 years with cancer are now well recognized. Dedicated care was initiated in 2012 in France under the leadership of the INCa (National Cancer Institute). Research on supportive care and particularly pain management are still rare. This study aimed to evaluate the consumption of toxic substances (tobacco, cannabis, alcohol) in AYAs with cancer as well as its progression during the month following the diagnosis and to analyze its influence on opioid analgesic prescriptions during treatment.
  
  
  METHODS
  This is a prospective study including all new patients aged 15-25 years in two centers between January and June 2013. Data on consumption of psychoactive substances were obtained during an individual interview with a questionnaire. National surveys were used to compare this cohort with the general population. Data on opioid treatments were collected from the computerized prescription software and computerized patient record.
  
  
  RESULTS
  Thirty-seven AYAs were eligible and 30 were included; 67% of them were male and the median age was 18.7 years. The questionnaire on tobacco, alcohol, and cannabis consumption at diagnosis was well accepted. Consumption profiles were comparable to the general population. Changes in behavior were observed during the 1st month after diagnosis, with a decrease or cessation of consumption, particularly among young people. This study showed differences in the use and requirements for opioid analgesics during hospitalization according to these consumption data.
  
  
  CONCLUSIONS
  Prevention and support for AYAs who are regular consumers of toxic substances must be organized during initial care in oncology.
authors.affiliation: Unité DAJAC (dispositif adolescents jeunes adultes), centre Léon-Bérard, Institut d'hématologie et d'oncologie pédiatrique, 1, place du Pr-J.-Renaut, 69373 Lyon cedex 08, France. Electronic address: amandine.bertrand@ihope.fr.
authors.forename: A
authors.initials: A
authors.lastname: Bertrand
authors.affiliation: Unité DAJAC (dispositif adolescents jeunes adultes), centre Léon-Bérard, Institut d'hématologie et d'oncologie pédiatrique, 1, place du Pr-J.-Renaut, 69373 Lyon cedex 08, France.
authors.forename: H
authors.initials: H
authors.lastname: Boyle
authors.affiliation: Unité DAJAC (dispositif adolescents jeunes adultes), centre Léon-Bérard, Institut d'hématologie et d'oncologie pédiatrique, 1, place du Pr-J.-Renaut, 69373 Lyon cedex 08, France.
authors.forename: J
authors.initials: J
authors.lastname: Moreaux
authors.affiliation: Département de pharmacie, centre Léon-Bérard, 1, place du Pr-J.-Renaut, 69373 Lyon cedex 08, France.
authors.forename: L
authors.initials: L
authors.lastname: Guillot
authors.affiliation: Unité DAJAC (dispositif adolescents jeunes adultes), centre Léon-Bérard, Institut d'hématologie et d'oncologie pédiatrique, 1, place du Pr-J.-Renaut, 69373 Lyon cedex 08, France.
authors.forename: G
authors.initials: G
authors.lastname: Chvetzoff
authors.affiliation: Département de pharmacie, centre Léon-Bérard, 1, place du Pr-J.-Renaut, 69373 Lyon cedex 08, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Charbonnel
authors.affiliation: Unité DAJAC (dispositif adolescents jeunes adultes), centre Léon-Bérard, Institut d'hématologie et d'oncologie pédiatrique, 1, place du Pr-J.-Renaut, 69373 Lyon cedex 08, France.
authors.forename: P
authors.initials: P
authors.lastname: Marec-Berard
mesh_terms: D000293:Adolescent; D000428:Alcohol Drinking / Q000009:adverse effects*; D000698:Analgesia; D000700:Analgesics / Q000627:therapeutic use*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000150:complications*; D009369:Neoplasms / Q000150:complications*; D010146:Pain / Q000209:etiology; D059408:Pain Management; D011446:Prospective Studies; D012907:Smoking / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000700:Analgesics