title: Kv1.5 Inhibitors for Treatment of Atrial Fibrillation: A Tradeoff between Selectivity and Non-selectivity.
abstract: Atrial fibrillation (AF) is one of the common arrhythmias that threatens human health and brings a huge burden to society. Current treatments of AF possess limited efficacy and considerable risks, so a lot of efforts have been made to develop new AF therapies. Kv1.5 potassium channel is considered as an efficacious and safe therapeutic target of AF for its selective existence in atrium. This review will give a brief profile of Kv1.5 potassium channel and describe the progress of Kv1.5 inhibitors in this decade from nonselective drugs to selective agents. The final section will discuss the advantages and disadvantages between selectivity and non-selectivity.
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Guo
authors.forename: Weilin
authors.initials: W
authors.lastname: Chen
authors.affiliation: sunhaopeng@163.com.
authors.forename: Haopeng
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China. youqd@cpu.edu.cn.
authors.forename: Qidong
authors.initials: Q
authors.lastname: You
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D006801:Humans; D051666:Kv1.5 Potassium Channel / Q000037:antagonists & inhibitors; D015394:Molecular Structure; D026902:Potassium Channel Blockers / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000889:Anti-Arrhythmia Agents; D051666:Kv1.5 Potassium Channel; D026902:Potassium Channel Blockers