title: Cdx-2 polymorphism in Vitamin D Receptor gene was associated with serum 25-hydroxyvitamin D levels, bone mineral density and fracture in middle-aged and elderly Chinese women.
abstract: The aim of the current study was to examine the relationship between Cdx-2 polymorphism in the promoter region of the VDR gene and serum 25-hydroxyvitamin D (25(OH)D) levels, bone mineral density (BMD) and fracture in Chinese population. This was a cross-sectional study, which included 738 individuals (428 women and 310 men) aged 45 years or older. In women, the association of Cdx-2 polymorphism with serum 25(OH)D levels was significant adjusting for age, BMI, estimated glomerular filtration rate, menopausal status and season of blood collection (P = 0.002). Cdx-2 polymorphism was associated with lumbar spine BMD adjusted for age, BMI, menopausal status and serum 25(OH)D in women (P = 0.005). But it was not associated with femoral neck BMD or total hip BMD in women. In women, Cdx-2 polymorphism was also associated with fracture adjusted for age, BMI, menopausal status, serum 25(OH)D and total hip BMD (P = 0.03). Carriers of AA and AG genotypes was associated with a higher odds of fracture compared with the carriers of GG genotype (OR = 2.14, 95% CI 1.04-4.42 and OR = 1.90, 95% CI 1.03-3.51). In men, Cdx-2 polymorphism was not associated with serum 25(OH)D levels, BMD or fracture. Our results indicate that the association of Cdx-2 polymorphism in the VDR gene with serum 25(OH)D levels, BMD and fracture may have sex differences. Cdx-2 polymorphism in the VDR gene may affect the serum 25(OH)D concentrations and the risk of osteoporosis and fracture in middle-aged and elderly Chinese women.
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University and Institute of Chronic Metabolic Diseases of Fudan University, No. 180 Fenglin Road, 200032 Shanghai, China. Electronic address: ling.yan@zs-hospital.sh.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ling
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University and Institute of Chronic Metabolic Diseases of Fudan University, No. 180 Fenglin Road, 200032 Shanghai, China. Electronic address: lin.huandong@zs-hospital.sh.cn.
authors.forename: Huandong
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University and Institute of Chronic Metabolic Diseases of Fudan University, No. 180 Fenglin Road, 200032 Shanghai, China. Electronic address: qqg2012flxq@126.com.
authors.forename: Qiqige
authors.initials: Q
authors.lastname: Aleteng
authors.affiliation: Department of Geriatrics, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032 Shanghai, China. Electronic address: ma.hui@zs-hospital.sh.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Laboratory Medicine, Zhongshan Hospital, Fudan University and Institute of Chronic Metabolic Diseases of Fudan University, No. 180 Fenglin Road, 200032 Shanghai, China. Electronic address: pan.baishen@zs-hospital.sh.cn.
authors.forename: Baishen
authors.initials: B
authors.lastname: Pan
authors.affiliation: Department of Clinical Nutrition, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032 Shanghai, China. Electronic address: gao.jian@zs-hospital.sh.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University and Institute of Chronic Metabolic Diseases of Fudan University, No. 180 Fenglin Road, 200032 Shanghai, China. Electronic address: happy20061208@126.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D001665:Binding Sites / Q000235:genetics; D015519:Bone Density / Q000235:genetics; D000071616:CDX2 Transcription Factor; D005260:Female; D050723:Fractures, Bone / Q000097:blood / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D018167:Receptors, Calcitriol; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Bone mineral density; Cdx-2 polymorphism; Fracture; Serum 25-hydroxyvitamin D; Vitamin D Receptor gene