title: Atherosclerotic renal artery stenosis in the post-CORAL era part 2: new directions in Transcatheter Nephron Salvage following flawed revascularization trials.
abstract: Unlike endovascular therapeutic studies for atherosclerosis in many other vascular beds, major trials regarding endovascular renovascular revascularization have resulted in a stagnating equipoise. However, every major trial completed for this topic thus far has suffered from major methodological flaws that limit the validity and external generalizability of their results. Furthermore, certain patient populations who are known to benefit from renovascular revascularization may never be studied because they cannot be ethically withheld from life-saving treatment. Forthcoming percutaneous techniques may one day complement angioplasty and stenting in a burgeoning era of cellular modulation and endovascular-directed renal regeneration.
authors.affiliation: Division of Interventional Radiology, Department of Radiology, Koc University School of Medicine, Istanbul, Turkey.
authors.forename: Alan Alper
authors.initials: AA
authors.lastname: Sag
authors.affiliation: Division of Interventional Radiology, Department of Radiology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Sos
authors.affiliation: Koc University, School of Medicine, Istanbul, Turkey.
authors.forename: Caghan
authors.initials: C
authors.lastname: Benli
authors.affiliation: Koc University, School of Medicine, Istanbul, Turkey.
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Sal
authors.affiliation: INSERM, Centre d'Investigations cliniques-plurithématique 1433, Inserm U1116; CHU Nancy; Université de Lorraine; F-CRININI-CRCT network, Nancy, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Rossignol
authors.affiliation: Instituto de Investigacion Sanitaria de la Fundacion Jimenez Diaz (IIS-FJD), School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain; Fundacion Renal Iñigo Alvarez de Toledo-IRSIN and REDINREN, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ortiz
authors.affiliation: Division of Nephrology, Department of Medicine, Sakarya Training and Research Hospital, Sakarya, Turkey.
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Solak
authors.affiliation: Division of Nephrology, Department of Medicine, Koç University School of Medicine, Istanbul, Turkey. Electronic address: mkanbay@ku.edu.tr.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanbay
mesh_terms: D017130:Angioplasty / Q000295:instrumentation / Q000379:methods / Q000639:trends; D050197:Atherosclerosis / Q000150:complications*; D054855:Drug-Eluting Stents / Q000639:trends; D057510:Endovascular Procedures / Q000379:methods* / Q000639:trends*; D019317:Evidence-Based Medicine / Q000379:methods; D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D009399:Nephrons / Q000601:surgery; D000072356:Parenchymal Tissue / Q000000981:diagnostic imaging / Q000473:pathology; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*
keywords: Angioplasty; Atherosclerosis; Hypertension; Stents