title: Phoma glomerata D14: An Endophytic Fungus from Salvia miltiorrhiza That Produces Salvianolic Acid C.
abstract: In recent years, more and more researches focus on endophytic fungi derived from important medicinal plants, which can produce the same bioactive metabolites as their host plants. Salvia miltiorrhiza Bunge is a traditional medicinal plant with versatile pharmacological effects. But the wild plant resource has been in short supply due to the overcollection for bioactive metabolites. Our study was therefore conducted to isolate endophytic fungi from S. miltiorrhiza and get candidate strains that produce the same bioactive compounds as the plant. As a result, an endophyte that produces salvianolic acid C was obtained and identified as Phoma glomerata D14 based on its morphology and internal transcribed spacer analysis. Salvianolic acid C was found present in both the mycelia and fermentation broth. Our study indicates that the endophytic fungus has significant industrial potential to meet the pharmaceutical demands for salvianolic acid C in a cost-effective, easily accessible, and reproducible way.
authors.affiliation: School of Ecological and Environmental Science, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.|Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhai
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.
authors.forename: Zhiheng
authors.initials: Z
authors.lastname: Shu
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.
authors.forename: Ruifang
authors.initials: R
authors.lastname: Dong
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.
authors.forename: Qianliang
authors.initials: Q
authors.lastname: Ming
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China. qinsmmu@126.com.
authors.forename: Luping
authors.initials: L
authors.lastname: Qin
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China. zhengchengjian@smmu.edu.cn.
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zheng
mesh_terms: D000475:Alkenes; D001203:Ascomycota / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D060026:Endophytes / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D025282:Mycelium / Q000378:metabolism; D059808:Polyphenols / Q000096:biosynthesis*; D027561:Salvia miltiorrhiza / Q000382:microbiology*; D001572:Benzofurans
chemical_list: D000475:Alkenes; D059808:Polyphenols; C000597819:salvianolic acid C; D001572:Benzofurans