title: Early complications after interventions in patients with acute pancreatitis.
abstract: OBJECTIVE
  To identify the possible predictors of early complications after the initial intervention in acute necrotizing pancreatitis.
  
  
  METHODS
  We collected the medical records of 334 patients with acute necrotizing pancreatitis who received initial intervention in our center. Complications associated with predictors were analyzed.
  
  
  RESULTS
  The postoperative mortality rate was 16% (53/334). Up to 31% of patients were successfully treated with percutaneous catheter drainage alone. The rates of intra-abdominal bleeding, colonic fistula, and progressive infection were 15% (50/334), 20% (68/334), and 26% (87/334), respectively. Multivariate analysis indicated that Marshall score upon admission, multiple organ failure, preoperative respiratory infection, and sepsis were the predictors of postoperative progressive infection (P < 0.05). Single organ failure, systemic inflammatory response syndrome upon admission, and C-reactive protein level upon admission were the risk factors of postoperative colonic fistula (P < 0.05). Moreover, preoperative Marshall score, organ failure, sepsis, and preoperative systemic inflammatory response syndrome were the risk factors of postoperative intra-abdominal bleeding (P < 0.05).
  
  
  CONCLUSIONS
  Marshall score, organ failures, preoperative respiratory infection, sepsis, preoperative systemic inflammatory response syndrome, and C-reactive protein level upon admission are associated with postoperative complications.
authors.affiliation: Ai-Lin Wei, Qiang Guo, Ming-Jun Wang, Wei-Ming Hu, Zhao-Da Zhang, Department of Pancreatic Surgery, West China Hospital, Chengdu 610041, Sichuan Province, China.
authors.forename: Ai-Lin
authors.initials: AL
authors.lastname: Wei
authors.affiliation: Ai-Lin Wei, Qiang Guo, Ming-Jun Wang, Wei-Ming Hu, Zhao-Da Zhang, Department of Pancreatic Surgery, West China Hospital, Chengdu 610041, Sichuan Province, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Ai-Lin Wei, Qiang Guo, Ming-Jun Wang, Wei-Ming Hu, Zhao-Da Zhang, Department of Pancreatic Surgery, West China Hospital, Chengdu 610041, Sichuan Province, China.
authors.forename: Ming-Jun
authors.initials: MJ
authors.lastname: Wang
authors.affiliation: Ai-Lin Wei, Qiang Guo, Ming-Jun Wang, Wei-Ming Hu, Zhao-Da Zhang, Department of Pancreatic Surgery, West China Hospital, Chengdu 610041, Sichuan Province, China.
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Hu
authors.affiliation: Ai-Lin Wei, Qiang Guo, Ming-Jun Wang, Wei-Ming Hu, Zhao-Da Zhang, Department of Pancreatic Surgery, West China Hospital, Chengdu 610041, Sichuan Province, China.
authors.forename: Zhao-Da
authors.initials: ZD
authors.lastname: Zhang
mesh_terms: D018806:APACHE; D000208:Acute Disease; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000209:etiology / Q000401:mortality; D016009:Chi-Square Distribution; D002681:China; D003108:Colonic Diseases / Q000209:etiology / Q000401:mortality; D015897:Comorbidity; D004322:Drainage / Q000009:adverse effects* / Q000401:mortality; D005260:Female; D006801:Humans; D007412:Intestinal Fistula / Q000209:etiology / Q000401:mortality; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010180:Pancreatectomy / Q000009:adverse effects* / Q000401:mortality; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D011183:Postoperative Complications / Q000209:etiology* / Q000401:mortality; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000401:mortality; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: Acute necrotizing pancreatitis; Colonic fistula; Intervention complications; Intra-abdominal bleeding; Progressive infection