title: A history of breast cancer and older age allow risk stratification of mammographic BI-RADS 3 ratings in the diagnostic setting.
abstract: OBJECTIVE
  The objective was to investigate whether risk stratification of mammographic Breast Imaging: Reporting and Data System (BI-RADS) 3 can be accomplished in the diagnostic setting.
  
  
  METHODS
  We analyzed 4941 BI-RADS-3-rated patients (23 malignant outcomes) and built logistic-regression models with age, personal and family history of breast cancer, fibroglandular density, and additional mammographic findings as predictive variables.
  
  
  RESULTS
  A personal history of breast cancer (odds ratio: 5.53) and older age (odds ratio: 12.44/10.93 for age 50-64/>64) are independent risk factors. Patients with both risk factors have a risk >2%.
  
  
  CONCLUSIONS
  Biopsy may be warranted in older patients with a history of breast cancer who would be otherwise assigned BI-RADS 3.
authors.affiliation: University Hospital Freiburg, Department of Radiology, Hugstetter Straße 55, 79106 Freiburg, Germany. Electronic address: matthias.benndorf@uniklinik-freiburg.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Benndorf
authors.affiliation: Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address: ywu@uwhealth.org.
authors.forename: Yirong
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address: eburnside@uwhealth.org.
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Burnside
mesh_terms: D001706:Biopsy; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D009367:Neoplasm Staging; D018570:Risk Assessment; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
keywords: BI-RADS; Breast cancer; Mammography; Probably benign; Risk stratification