title: Maternal obesity alters the apelinergic system at the feto-maternal interface.
abstract: Apelin and its receptor APJ have been implicated in pathologies including cardiovascular disease, diabetes and obesity. Little is known about the function of the apelinergic system during gestation. We evaluated in mice this system at the feto-maternal interface in insulin-resistant obese female (HF) mice. Maternal apelinemia was decreased at term and fetal apelinemia was sixfold higher than maternal level. Ex-vivo, the placenta releases apelin at E12.5 and E18.5. In HF pregnant mice at term, apelinemia as well as placental apelin and APJ mRNA levels were increased whereas placental release of apelin was drastically reduced compared to controls.
authors.affiliation: CHRU of Lille, Jeanne de Flandre Hospital, Gynecology-Obstetrics, Lille, France; Univ. Lille, Unité Environnement Périnatal et Santé, EA 4489, Faculté de Médecine, Pôle recherche, IFR 114, 59045 Lille, France.
authors.forename: Sandy
authors.initials: S
authors.lastname: Hanssens
authors.affiliation: CHRU of Lille, Jeanne de Flandre Hospital, Gynecology-Obstetrics, Lille, France; Univ. Lille, Unité Environnement Périnatal et Santé, EA 4489, Faculté de Médecine, Pôle recherche, IFR 114, 59045 Lille, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Marx-Deseure
authors.affiliation: University of Lille 1, EA 4489, Villeneuve d'Ascq, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Lecoutre
authors.affiliation: Univ. Lille, Unité Environnement Périnatal et Santé, EA 4489, Faculté de Médecine, Pôle recherche, IFR 114, 59045 Lille, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Butruille
authors.affiliation: Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Team 3, INSERM U1048, 31432 Toulouse, France.
authors.forename: Audren
authors.initials: A
authors.lastname: Fournel
authors.affiliation: Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Team 3, INSERM U1048, 31432 Toulouse, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Knauf
authors.affiliation: Univ. Lille, Unité Environnement Périnatal et Santé, EA 4489, Faculté de Médecine, Pôle recherche, IFR 114, 59045 Lille, France.
authors.forename: Capucine
authors.initials: C
authors.lastname: Besengez
authors.affiliation: University of Lille 1, EA 4489, Villeneuve d'Ascq, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Breton
authors.affiliation: CHRU of Lille, Jeanne de Flandre Hospital, Gynecology-Obstetrics, Lille, France; CHRU of Lille, Jeanne de Flandre Hospital, Neonatal Reanimation, Lille, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Storme
authors.affiliation: CHRU of Lille, Jeanne de Flandre Hospital, Gynecology-Obstetrics, Lille, France; Univ. Lille, Unité Environnement Périnatal et Santé, EA 4489, Faculté de Médecine, Pôle recherche, IFR 114, 59045 Lille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Deruelle
authors.affiliation: University of Lille 1, EA 4489, Villeneuve d'Ascq, France. Electronic address: jean.lesage@univ-lille1.fr.
authors.forename: Jean
authors.initials: J
authors.lastname: Lesage
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000818:Animals; D000073861:Apelin; D005260:Female; D005333:Fetus / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction
chemical_list: D054392:Adipokines; D000073861:Apelin; C402826:Apln protein, mouse; D036341:Intercellular Signaling Peptides and Proteins
keywords: APJ; Apelin; Fetus; Maternal obesity; Mice; Placenta