title: Opioid-Induced Constipation Survey in Patients with Chronic Noncancer Pain.
abstract: Chronic pain patients relying on chronic opioid therapy are often challenged with opioid-induced constipation (OIC), a difficult condition to treat that has a significant psychosocial impact on those who are affected (Bruner et al., J Pain Res, 8, 2015, 289). Unlike other side effects of opioids, OIC does not resolve over time during chronic opioid use, and treatments used for functional constipation often fail to provide adequate symptom relief (Nelson and Camilleri, Therap Adv Gastroenterol, 8, 2015, 206). Estimates of the prevalence of OIC vary. It has been reported that 15% to 90% of opioid users are affected by OIC (Gaertner et al., J Clin Gastroenterol, 49, 2015, 9; Wan et al., Am Health Drug Benefits, 8, 2015, 93; Coyne et al., Clinicoecon Outcomes Res, 6, 2014, 269). In addition, a recent rise in opioid prescriptions by nonpain specialists has contributed to the increase in opioid-related side effects, such as OIC (Nelson and Camilleri, Therap Adv Gastroenterol, 8, 2015, 206; Tuteja et al., Neurogastroenterol Motil, 22, 2010, 424). We conducted a survey on OIC through PainPathways magazine in fall of 2014 and in spring of 2015. Survey results showed the prevalence of depression and the modification of opioid dosage were higher than previously thought. Additionally, we found that discussions with healthcare workers regarding OIC do not take place regularly. Our results re-emphasize the need for a consensus on OIC-specific diagnostic criteria, evidence-based treatment strategies, outcome metrics, and education about OIC for both prescribers and patients to improve clinical outcome as well as patient satisfaction.
authors.affiliation: Carolinas Pain Institute, and Pain Pathways Magazine, Winston-Salem, North Carolina, U.S.A.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Rauck
authors.affiliation: Center for Clinical Research, Winston-Salem, North Carolina, U.S.A.
authors.forename: Kyung-Soo Jason
authors.initials: KJ
authors.lastname: Hong
authors.affiliation: Carolinas Pain Institute, and Pain Pathways Magazine, Winston-Salem, North Carolina, U.S.A.
authors.forename: James
authors.initials: J
authors.lastname: North
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects* / Q000627:therapeutic use; D059350:Chronic Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology*; D003248:Constipation / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D017060:Patient Satisfaction; D011788:Quality of Life / Q000523:psychology; D011795:Surveys and Questionnaires
chemical_list: D000701:Analgesics, Opioid
keywords: chronic noncancer pain; chronic pain; opioid analgesics; opioid-induced bowel dysfunction; opioid-induced constipation; survey