title: The squaramide-catalyzed asymmetric Michael/cyclization tandem reaction for the synthesis of chiral trifluoromethylated hydroxyimino tetrahydrobenzofuranones.
abstract: An enantioselective synthesis of trifluoromethylated hydroxyimino tetrahydrobenzofuranones has been developed. 1,3-Dicarbonyl carbocyclic compounds react with β-CF3-β-disubstituted nitroalkenes in the presence of a chiral squaramide catalyst, providing efficient access to diverse hydroxyimino tetrahydrobenzofuranones featuring a trifluoromethyl group at the C3-position of an all-carbon quaternary stereocenter with good yields (up to 81%) and enantioselectivities (up to 89% ee).
authors.affiliation: Department of Pharmacy, School of chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, People's Republic of China. sycmichael@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Lai
authors.forename: Gaofeng
authors.initials: G
authors.lastname: Zha
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: Panpan
authors.initials: P
authors.lastname: Sun
authors.forename: Tao
authors.initials: T
authors.lastname: Xia
authors.forename: Yongcun
authors.initials: Y
authors.lastname: Shen