title: Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans.
abstract: High abundance of brown adipose tissue (BAT) is linked to lower glycaemia in humans, leading to the belief that BAT may protect against diabetes. The relationship between BAT glucose utilization and systemic glucose homeostasis has not been defined. In this paper we have characterized glycaemic excursions and BAT thermogenic responses in human brown adipocytes, BAT explants, and healthy adults through supraclavicular temperature profiling, revealing their circadian coupling in vivo and in vitro, orchestrated by UCP1, GLUT4, and Rev-erbα biorhythms. Extent of glycated haemoglobin also correlated positively with environmental temperature among community-dwelling patients. These data uncover potential crosstalk between BAT and glucose regulatory pathways, evident on cellular, tissue, individual, and population levels, and provide impetus to search for BAT harnessing strategies for therapeutic purposes.
authors.affiliation: Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; Department of Endocrinology, St. Vincent's Hospital, Sydney, NSW 2010, Australia; Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: p.lee@garvan.org.au.
authors.forename: Paul
authors.initials: P
authors.lastname: Lee
authors.affiliation: Department of Surgery, St. Vincent's Hospital, Sydney, NSW 2010, Australia.
authors.forename: Ron
authors.initials: R
authors.lastname: Bova
authors.affiliation: Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; Department of Endocrinology, St. Vincent's Hospital, Sydney, NSW 2010, Australia.
authors.forename: Lynne
authors.initials: L
authors.lastname: Schofield
authors.affiliation: Diabetes Centre, St. Vincent's Hospital, Sydney, NSW 2010, Australia.
authors.forename: Wendy
authors.initials: W
authors.lastname: Bryant
authors.affiliation: Department of Positron Emission Tomography, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: William
authors.initials: W
authors.lastname: Dieckmann
authors.affiliation: Department of PET and Nuclear Medicine, St. Vincent's Hospital, Sydney, NSW 2010, Australia.
authors.forename: Anthony
authors.initials: A
authors.lastname: Slattery
authors.affiliation: Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
authors.forename: Matt A
authors.initials: MA
authors.lastname: Govendir
authors.affiliation: Department of PET and Nuclear Medicine, St. Vincent's Hospital, Sydney, NSW 2010, Australia.
authors.forename: Louise
authors.initials: L
authors.lastname: Emmett
authors.affiliation: Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; Department of Endocrinology, St. Vincent's Hospital, Sydney, NSW 2010, Australia; Diabetes Centre, St. Vincent's Hospital, Sydney, NSW 2010, Australia; Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
authors.forename: Jerry R
authors.initials: JR
authors.lastname: Greenfield
mesh_terms: D052437:Adipocytes, Brown / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000502:physiology*; D000328:Adult; D002478:Cells, Cultured; D002940:Circadian Rhythm; D005260:Female; D005947:Glucose / Q000378:metabolism*; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D056953:Nuclear Receptor Subfamily 1, Group D, Member 1 / Q000378:metabolism; D022722:Thermogenesis; D000071256:Uncoupling Protein 1 / Q000378:metabolism; D055815:Young Adult
chemical_list: D051275:Glucose Transporter Type 4; C064353:NR1D1 protein, human; D056953:Nuclear Receptor Subfamily 1, Group D, Member 1; C495692:SLC2A4 protein, human; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1; D005947:Glucose
keywords: GLUT4; Rev-erb; UCP1; beige adipose; circadian