title: BIRDSHOT CHORIORETINITIS LESIONS ON INDOCYANINE GREEN ANGIOGRAPHY AS AN INDICATOR OF DISEASE ACTIVITY.
abstract: OBJECTIVE
  To determine whether classical indocyanine green angiography lesions in patients with birdshot chorioretinitis can be used to monitor disease activity.
  
  
  METHODS
  A retrospective case series was performed on 26 eyes in 26 consecutive patients with birdshot chorioretinitis who had at least one indocyanine green angiography performed during disease activity and another during disease quiescence. Using Photoshop, the mean number, area, and area per spot on indocyanine green angiography were compared between disease activity and quiescence using a paired ratio test.
  
  
  RESULTS
  The mean total lesion number, area, and area per spot during disease activity were 75.27 spots, 24,525 pixels, and 364 pixels/spots, respectively. The mean total lesion number, area, and area per spot size during disease quiescence were 28.35 spots (P < 0.01), 7,411 pixels (P < 0.01), and 279 pixels/spot (P = 0.12), respectively.
  
  
  CONCLUSIONS
  There was a statistically significant decrease in the mean total area and number of lesions between the time of disease activity and disease quiescence (P < 0.01). Our results suggest that indocyanine green angiography has a role not only in diagnosis but also in monitoring treatment effectiveness; lesions can be reversible with treatment and their reappearance may be an indicator of disease relapse.
authors.affiliation: *Massachusetts Eye Research and Surgery Institution (MERSI), Cambridge, Massachusetts; †Ocular Immunology and Uveitis Foundation, Cambridge, Massachusetts; ‡Department of Ophthalmology, Faculty of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand; and §Harvard Medical School, Cambridge, Massachusetts.
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Cao
authors.forename: Sukhum
authors.initials: S
authors.lastname: Silpa-Archa
authors.forename: Clovis A
authors.initials: CA
authors.lastname: Freitas-Neto
authors.forename: C Stephen
authors.initials: CS
authors.lastname: Foster
mesh_terms: D000328:Adult; D000080365:Birdshot Chorioretinopathy; D002825:Chorioretinitis / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D004396:Coloring Agents / Q000008:administration & dosage*; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007208:Indocyanine Green / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology; D012189:Retrospective Studies; D014794:Visual Fields / Q000502:physiology
chemical_list: D004396:Coloring Agents; D007166:Immunosuppressive Agents; D007208:Indocyanine Green