title: Anti-oxidative, anti-secretory and anti-inflammatory activities of the extract from the root bark of Lycium chinense (Cortex Lycii) against gastric ulcer in mice.
abstract: The evaluation of the antioxidant, anti-secretory and anti-inflammatory potentials of the ethyl acetate fraction (ELC) from the root bark of Lycium chinense against ethanol-induced gastric ulcer in mice and the possible mechanisms underlying this action was performed. The results indicated that oral administration of ELC (50, 100, 200 and 400 mg/kg) before ethanol-induced ulcer increased the gastric mucus content, restored the superoxide dismutase and glutathione levels, reduced malondialdehyde levels and inhibited the activity of myeloperoxidase. Furthermore, ELC displayed its anti-secretory activity by decreasing the gastric juice and increased the gastric pH and reduced pro-inflammatory markers and caspase-3 tissue levels. These results suggest that L. chinense displays gastroprotective properties as a result of its antioxidant, anti-inflammatory, anti-secretory and anti-apoptotic effects.
authors.affiliation: Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden Mem. Sun Yat-sen, No. 1 Qianhuhoucun, P. O. Box 1435, Nanjing, 210014, China.|School of Pharmacy, Jiangsu University, Zhenjiang, 212013, China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Jiangsu University, Zhenjiang, 212013, China.
authors.forename: Opeyemi J
authors.initials: OJ
authors.lastname: Olatunji
authors.affiliation: Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden Mem. Sun Yat-sen, No. 1 Qianhuhoucun, P. O. Box 1435, Nanjing, 210014, China. njgzhou@163.com.|Dongtai Institute of Tidal Flat, Nanjing Branch of Chinese Academy of Sciences, Dongtai, 224200, China. njgzhou@163.com.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000737:chemistry; D000975:Antioxidants / Q000627:therapeutic use*; D032305:Lycium / Q000737:chemistry*; D008297:Male; D051379:Mice; D018384:Oxidative Stress; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced*
chemical_list: D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D000975:Antioxidants; D010936:Plant Extracts
keywords: Anti-inflammatory; Antioxidant; Cortex Lycii; Ethanol; Lycium chinense