title: Physical Sequestration of Bacillus anthracis in the Pulmonary Capillaries in Terminal Infection.
abstract: The lung is the terminal target of Bacillus anthracis before death, whatever the route of infection (cutaneous, inhalational, or digestive). During a cutaneous infection in absence of toxins, we observed encapsulated bacteria colonizing the alveolar capillary network, bacteria and hemorrhages in alveolar and bronchiolar spaces, and hypoxic foci in the lung (endothelial cells) and brain (neurons and neuropil). Circulating encapsulated bacteria were as chains of approximately 13 µm in length. Bacteria of such size were immediately trapped within the lung capillary network, but bacteria of shorter length were not. Controlling lung-targeted pathology would be beneficial for anthrax treatment.
authors.affiliation: Institut Pasteur, Histopathologie Humaine et Modèles Animaux PRES Sorbonne-Paris-Cité, Paris Descartes University.
authors.forename: Gregory
authors.initials: G
authors.lastname: Jouvion
authors.affiliation: Pathogénie des Toxi-Infections Bactériennes.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Corre
authors.affiliation: Institut Pasteur, Histopathologie Humaine et Modèles Animaux.
authors.forename: Huot
authors.initials: H
authors.lastname: Khun
authors.affiliation: Plate-Forme de Microscopie Ultrastructurale.
authors.forename: Marie
authors.initials: M
authors.lastname: Moya-Nilges
authors.affiliation: Imagopole-Citech.
authors.forename: Pascal
authors.initials: P
authors.lastname: Roux
authors.affiliation: Institut Pasteur, Histopathologie Humaine et Modèles Animaux.
authors.forename: Claire
authors.initials: C
authors.lastname: Latroche
authors.affiliation: Pathogénie des Toxi-Infections Bactériennes Ecole du Val-de-Grâce Unité Interactions Hôte-Agents Pathogènes, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.
authors.forename: Jean-Nicolas
authors.initials: JN
authors.lastname: Tournier
authors.affiliation: URE Histotechnologie et Pathologie, Institut Pasteur.
authors.forename: Michel
authors.initials: M
authors.lastname: Huerre
authors.affiliation: Institut Pasteur, Histopathologie Humaine et Modèles Animaux PRES Sorbonne-Paris-Cité, Paris Descartes University Neuropathology Unit, CH Sainte-Anne, Paris.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Chrétien
authors.affiliation: Institut Pasteur, Histopathologie Humaine et Modèles Animaux Pathogénie des Toxi-Infections Bactériennes.
authors.forename: Pierre L
authors.initials: PL
authors.lastname: Goossens
mesh_terms: D000818:Animals; D000881:Anthrax / Q000382:microbiology* / Q000473:pathology*; D001408:Bacillus anthracis / Q000302:isolation & purification*; D002196:Capillaries / Q000382:microbiology* / Q000473:pathology; D004195:Disease Models, Animal; D006651:Histocytochemistry; D007150:Immunohistochemistry; D008168:Lung / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D046529:Microscopy, Electron, Transmission
keywords: anthrax; histopathology; lung infection; mice; polyglutamate capsule