title: [Role of SD-OCT in the diagnosis and prognosis of macular hypoplasia in nystagmus patients].
abstract: OBJECTIVE
  To investigate whether spectral domain optical coherence tomography (SD-OCT) is helpful for the diagnosis and prognosis of foveal hypoplasia in patients with overt nystagmus.
  
  
  METHODS
  A retrospective cross-sectional study was conducted in 48 patients with overt nystagmus. All patients underwent a complete ophthalmic examination including best corrected visual acuity, biomicroscopic and fundus examinations. Spectral domain optical coherence tomography was performed using 3D OCT-2000 FA PLUS Topcon, Tokyo, Japan, for the diagnosis and grading of foveal hypoplasia, using the Thomas classification, and its possible correlation with visual acuity.
  
  
  RESULTS
  Foveal hypoplasia was diagnosed in 6 patients (12.5%). The mean age of the patients was 13.2 years (10-18 years). Mean visual acuity was 1.53/10 (0.87 LogMAR). Foveal hypoplasia was associated with aniridia in 2 patients, albinism in 3 patients and keratoconus in 1 case. On SD-OCT, foveal hypoplasia was grade 4 in 4 patients and grade 3 in 2 patients. Mean visual acuity was 2.55/10 in patients with grade 3 foveal hypoplasia and 1.22/10 in patients with grade 4 foveal hypoplasia, and the difference in visual acuity between the two groups was statistically significant (P<0.001).
  
  
  CONCLUSIONS
  SD-OCT plays a double role in the diagnosis and prognosis of foveal hypoplasia in patients with nystagmus.
authors.affiliation: Service B, faculté de médecine de Tunis, institut Hédi Rais d'ophtalmologie de Tunis, université Tunis El Manar, boulevard du 9-Avril-1938, Tunis, Tunisie.
authors.forename: R
authors.initials: R
authors.lastname: Bouraoui
authors.affiliation: Service B, faculté de médecine de Tunis, institut Hédi Rais d'ophtalmologie de Tunis, université Tunis El Manar, boulevard du 9-Avril-1938, Tunis, Tunisie. Electronic address: mejdabouladi@yahoo.fr.
authors.forename: M
authors.initials: M
authors.lastname: Bouladi
authors.affiliation: Service B, faculté de médecine de Tunis, institut Hédi Rais d'ophtalmologie de Tunis, université Tunis El Manar, boulevard du 9-Avril-1938, Tunis, Tunisie.
authors.forename: F
authors.initials: F
authors.lastname: Nefaa
authors.affiliation: Service B, faculté de médecine de Tunis, institut Hédi Rais d'ophtalmologie de Tunis, université Tunis El Manar, boulevard du 9-Avril-1938, Tunis, Tunisie.
authors.forename: R
authors.initials: R
authors.lastname: Limaiem
authors.affiliation: Service B, faculté de médecine de Tunis, institut Hédi Rais d'ophtalmologie de Tunis, université Tunis El Manar, boulevard du 9-Avril-1938, Tunis, Tunisie.
authors.forename: L
authors.initials: L
authors.lastname: El Matri
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005124:Eye Abnormalities / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D005584:Fovea Centralis / Q000002:abnormalities*; D006801:Humans; D008297:Male; D009759:Nystagmus, Pathologic / Q000150:complications* / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D055815:Young Adult
keywords: Acuité visuelle; Foveal hypoplasia; Hypoplasie fovéolaire; Nystagmus; OCT spectral domain; Spectral domain OCT; Visual acuity