title: A single flexible RNAPII-CTD integrates many different transcriptional programs.
abstract: The RNAPII-CTD functions as a binding platform for coordinating the recruitment of transcription associated factors. Altering CTD function results in gene expression defects, although mounting evidence suggests that these effects likely vary among species and loci. Here we highlight emerging evidence of species- and loci-specific functions for the RNAPII-CTD.
authors.affiliation: a Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia , Vancouver , British Columbia , Canada.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Aristizabal
authors.affiliation: a Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia , Vancouver , British Columbia , Canada.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kobor
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D056426:Genetic Loci; D008322:Mammals / Q000235:genetics; D000072417:Protein Domains; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000235:genetics; D012568:Schizosaccharomyces / Q000201:enzymology* / Q000235:genetics; D013045:Species Specificity; D014158:Transcription, Genetic
chemical_list: D012319:RNA Polymerase II
keywords: C-terminal domain; CTD modifications; RNAPII; gene-specific; species-specific; transcription