title: Results of Further Diagnostic Procedures Among Patients with Cytological Characteristics of Minor Changes on Pap Smears.
abstract: BACKGROUND
  Atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesion (LSIL) are the two most common results of positive Pap smears.
  
  
  OBJECTIVE
  The aim of this study was to compare the management of patients with ASCUS and LSIL.
  
  
  METHODS
  All procedures were performed between 2003 and 2014 in an outpatient clinic affiliated to a tertiary referral center, and included Pap smears, colposcopy, histology and invasive treatment.
  
  
  RESULTS
  There were 131 patients in the ASCUS group and 84 in the LSIL group. Further negative cytological results were obtained more frequently among the ASCUS group than the LSIL group [relative risk (RR)=1.18, 95% confidence interval (CI)=1.33-2.40; p<0.001]. Histological results revealed higher occurrence of cervical intraepithelial neoplasia grade III or invasive squamous cancer in the LSIL group than the ASCUS group [RR=6.8 (95% CI=0.95-144.63), p=0.033]. Patients from the LSIL group more frequently required invasive treatment [RR=2.53, 95% CI=1.40-4.67, p=0.001].
  
  
  CONCLUSIONS
  Diagnosis of ASCUS is associated with more frequent cases of total remission in follow-up Pap smears and requires for less-invasive management.
authors.affiliation: Students' Scientific Group affiliated to the Second Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland asiakacperczyk@gmail.com.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kacperczyk
authors.affiliation: Students' Scientific Group affiliated to the Second Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Bartnik
authors.affiliation: Second Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Romejko-Wolniewicz
authors.affiliation: Second Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jalinik
mesh_terms: D065309:Atypical Squamous Cells of the Cervix / Q000473:pathology*; D019468:Disease Management; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D012189:Retrospective Studies; D065310:Squamous Intraepithelial Lesions of the Cervix / Q000473:pathology* / Q000628:therapy; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000628:therapy
keywords: ASCUS; LSIL; Pap smear; Screening; cervical cancer