title: [Pediatric medulloblastoma: Retrospective series of 52 patients].
abstract: OBJECTIVE
  Retrospective analysis of the results of 52 children irradiated for a medulloblastoma.
  
  
  METHODS
  Between 1974 and 2012, 52 children with an average age of 6 years and a half (11 months-17 years and a half) were treated with surgery then with radiotherapy at the Comprehensive Cancer Centre of Strasbourg (France). For 44 children, the treatment consisted of a chemotherapy.
  
  
  RESULTS
  After a mean follow-up of 106.6 months (7-446 months), 13 relapses and 24 deaths were observed. Overall survival at 5 years and 10 years were 62% and 57%, respectively. Disease-free survival at 5 years and 10 years were 80% and 63%, respectively. Univariate analysis found the following adverse prognostic factors: the existence of a postoperative residue, the positivity of the cerebrospinal fluid, the metastatic status and medulloblastoma of high-risk. Positivity of the cerebrospinal fluid remains a negative factor in multivariate analysis.
  
  
  CONCLUSIONS
  These results confirm the survival rate obtained by a conventional approach (surgery then irradiation). Insufficiency of results and rarity of medulloblastoma require the establishment of international protocols.
authors.affiliation: Département de radiothérapie, CLCC Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg, France.
authors.forename: C
authors.initials: C
authors.lastname: Vigneron
authors.affiliation: Département de radiothérapie, CLCC Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg, France.
authors.forename: D
authors.initials: D
authors.lastname: Antoni
authors.affiliation: Service de neurochirurgie, CHU Hautepierre, 67000 Strasbourg, France.
authors.forename: A
authors.initials: A
authors.lastname: Coca
authors.affiliation: Service d'oncologie pédiatrique, CHU Hautepierre, 67000 Strasbourg, France.
authors.forename: N
authors.initials: N
authors.lastname: Entz-Werlé
authors.affiliation: Service d'oncologie pédiatrique, CHU Hautepierre, 67000 Strasbourg, France.
authors.forename: P
authors.initials: P
authors.lastname: Lutz
authors.affiliation: Service d'oncologie pédiatrique, CHU Hautepierre, 67000 Strasbourg, France.
authors.forename: A
authors.initials: A
authors.lastname: Spiegel
authors.affiliation: Service d'oncologie pédiatrique, CHU Hautepierre, 67000 Strasbourg, France.
authors.forename: S
authors.initials: S
authors.lastname: Jannier
authors.affiliation: Département de radiothérapie, CLCC Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg, France.
authors.forename: C
authors.initials: C
authors.lastname: Niederst
authors.affiliation: Département de radiothérapie, CLCC Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg, France.
authors.forename: D
authors.initials: D
authors.lastname: Jarnet
authors.affiliation: Département de radiothérapie, CLCC Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg, France.
authors.forename: P
authors.initials: P
authors.lastname: Meyer
authors.affiliation: Service de neurochirurgie, CHU Hautepierre, 67000 Strasbourg, France.
authors.forename: P
authors.initials: P
authors.lastname: Kehrli
authors.affiliation: Département de radiothérapie, CLCC Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg, France; Laboratoire EA 3430, fédération de médecine translationnelle de Strasbourg (FMTS), université de Strasbourg, 67000 Strasbourg, France. Electronic address: gnoel@strasbourg.unicancer.fr.
authors.forename: G
authors.initials: G
authors.lastname: Noël
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002528:Cerebellar Neoplasms / Q000134:cerebrospinal fluid / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008297:Male; D008527:Medulloblastoma / Q000134:cerebrospinal fluid / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D008727:Methotrexate / Q000008:administration & dosage; D018365:Neoplasm, Residual / Q000473:pathology; D011344:Procarbazine / Q000008:administration & dosage; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D011344:Procarbazine; D014750:Vincristine; D008727:Methotrexate
keywords: Children; Enfants; Medulloblastoma; Médulloblastomes; Radiothérapie