title: Pure red cell aplasia due to azathioprine therapy for Crohn's disease.
abstract: Various mechanisms contribute to anemia in inflammatory bowel diseases (IBD), drug-related causes being less frequent. The hematological and other adverse events of azathioprine (AZA) therapy are well documented, but drug-associated pure red cell aplasia (PRCA) is an uncommon event. We hereby describe two cases of AZA-associated PRCA in patients with Crohn's disease. The diagnosis was supported by pathological reports, and prompt hematological recovery was seen with discontinuation of the offending drug. This report highlights the need to consider this rare entity in IBD patients in appropriate settings and for adopting adequate precautionary measures.
authors.affiliation: Department of Gastroenterology and Hepatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: Nagesh
authors.initials: N
authors.lastname: Kamath
authors.affiliation: Department of Gastroenterology and Hepatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: C Ganesh
authors.initials: CG
authors.lastname: Pai
authors.affiliation: Medical Student, CHRU Lille, Faculty Henri Warembourg, University of Lille2, Lille, France.
authors.forename: Thylbert
authors.initials: T
authors.lastname: Deltombe
mesh_terms: D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D003424:Crohn Disease / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced*
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine
keywords: Anemia; Crohn's disease; azathioprine; pure red cell aplasia