title: The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis.
abstract: Although a number of studies suggested that WT1 rs16754 polymorphism might be related to decreased relapse free survival (RFS) and overall survival (OS). The results remain controversial. Published reports were searched in PubMed, EMBASE, and Google Scholar. Twelve publications with 3903 patients had met the inclusion criteria and were subjected to further examination. We found WT1 rs16754 polymorphism was significantly associated with OS in AML (OR = 0.62; 95% CI 0.52 - 0.75; p < 0.00001; I2 = 47%). WT1 rs16754 polymorphism was also significantly associated with RFS in AML (OR = 0.69; 95% CI 0.57 - 0.83; p < 0.001; I2 = 46%). In the subgroup analyses of age, race, and subtype of AML, WT1 rs16754 polymorphism was a independent favorable-risk marker. In conclusion, WT1 rs16754 polymorphism is associated with better survival of AML. It could be used as a cost-effective prognostic biomarker for AML.
authors.affiliation: Department of Medicinal Oncology, The First Affiliated Hospital, SUN Yat-Sen University, Guangzhou 510080, China.
authors.forename: Jianting
authors.initials: J
authors.lastname: Long
authors.affiliation: Department of Clinic Nutrition, The First Affiliated Hospital, SUN Yat-Sen University, Guangzhou 510080, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Fang
authors.affiliation: Department of Medicinal Oncology, The First Affiliated Hospital, SUN Yat-Sen University, Guangzhou 510080, China.
authors.forename: Qiangsheng
authors.initials: Q
authors.lastname: Dai
authors.affiliation: Department of Hematology, Gaozhou People's Hospital, Gaozhou 525200, China.
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Hematology, Gaozhou People's Hospital, Gaozhou 525200, China.
authors.forename: Wanshou
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Vascular Surgery, The First Affiliated Hospital, SUN Yat-Sen University, Guangzhou 510080, China.
authors.forename: Shenming
authors.initials: S
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D025721:WT1 Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D025721:WT1 Proteins; C583751:WT1 protein, human
keywords: Wilms’ tumor gene 1; acute myeloid leukemia; association; meta-analysis