title: Evaluation of Fibrosis Markers: Apelin and Transforming Growth Factor-β1 in Autosomal Dominant Polycystic Kidney Disease Patients.
abstract: Renal interstitial fibrosis is an important pathological feature of autosomal dominant polycystic kidney disease (ADPKD), which progressively develops to end-stage renal disease (ESRD). It has been shown that apelin and transforming growth factor-β1 (TGF-β1) play important roles in the renal fibrosis process. The aim of the present study is to evaluate the relationship of these fibrosis markers and ADPKD. Forty-five patients with ADPKD and 28 healthy controls were studied cross-sectionally. Estimated glomerular filtration rate (eGFR), apelin, TGF-β1 were measured in all participants, using conventional methods. Apelin levels were lower (1.2 ± 0.9 ng/mL vs. 2.5 ±  1.3 ng/mL, P < 0.001), while TGF-β1 levels were higher in the patient group according to healthy controls (466.5 ±  200.5 ng/L vs. 367.1 ± 163.45 ng/L, P = 0.031), respectively. Apelin was negatively correlated with TGF-β1 and highly sensitive C-reactive protein (hs-CRP); and positively correlated with eGFR. In all subjects, eGFR was independently predicted by TGF-β1 and apelin. Apelin and TGF-β1 may be used as biomarkers of renal fibrosis that is an important pathological feature of ADPKD, which progressively develops to ESRD in ADPKD patients.
authors.affiliation: Department of Biochemistry, Training and Research Hospital, Kayseri, Turkey. ayder78@yahoo.com.
authors.forename: Derya
authors.initials: D
authors.lastname: Kocer
authors.affiliation: Department of Biochemistry, Training and Research Hospital, Kayseri, Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Karakukcu
authors.affiliation: Department of Internal Medicine, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Fahir
authors.initials: F
authors.lastname: Ozturk
authors.affiliation: Department of Internal Medicine, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Eray
authors.initials: E
authors.lastname: Eroglu
authors.affiliation: Department of Nephrology, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Kocyigit
mesh_terms: D000328:Adult; D000073861:Apelin; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005355:Fibrosis / Q000473:pathology; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000503:physiopathology*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins; D053773:Transforming Growth Factor beta1; D002097:C-Reactive Protein
keywords: Apelin; Fibrosis; Polycystic kidney disease; Transforming growth factor-β1