title: Alzheimer's Disease and Autistic Spectrum Disorder: Is there any Association?
abstract: Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are neurodevelopmental and neurodegenerative disorders respectively, with devastating effects not only on the individual but also the society. Collectively, a number of factors contribute to the expression of ASD and AD. It is of utmost curiosity that these disorders express at different stages of life and there is an involvement of certain susceptible genes. This genetic basis makes the background of common associations like memory deficits, cognition changes, demyelination, oxidative stress and inflammation, an integral part of both disorders. Modern technology resulting in genetically modified crops and increase in gadgets emitting electromagnetic frequencies have resulted in enhanced risks for neurological dysfunctions and disorders like ASD and AD. Subsequent advances in the psychological, pharmacological, biochemical and nutritional aspects of the disorders have resulted in the development of newer therapeutic approaches. The common clinical features like language impairment, executive functions, and motor problems have been discussed along with the patho-physiological changes, role of DNA methylation, myelin development, and heavy metals in the expression of these disorders. Psychopharmacological and nutritional approaches towards the reduction and management of risk factors have gained attention from the researchers in recent years. Current major therapies either target the inflammatory pathways or reduce cellular oxidative stress. This contribution focuses on the commonalities of the two disorders.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Khan
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Kingdom of Saudi Arabia. shahidakhan2009@gmail.com.
authors.forename: Shahida A
authors.initials: SA
authors.lastname: Khan
authors.forename: A R
authors.initials: AR
authors.lastname: Narendra
authors.forename: Gohar
authors.initials: G
authors.lastname: Mushtaq
authors.forename: Solafa A
authors.initials: SA
authors.lastname: Zahran
authors.forename: Shahzad
authors.initials: S
authors.lastname: Khan
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Kamal
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics / Q000628:therapy; D000067877:Autism Spectrum Disorder / Q000150:complications / Q000235:genetics / Q000628:therapy; D003072:Cognition Disorders / Q000209:etiology; D006801:Humans; D007249:Inflammation / Q000150:complications; D007806:Language Disorders / Q000209:etiology; D009069:Movement Disorders / Q000209:etiology; D018384:Oxidative Stress / Q000502:physiology; D011619:Psychotropic Drugs / Q000627:therapeutic use
chemical_list: D011619:Psychotropic Drugs