title: [Intravitreal bevacizumab in AMD complicated by submacular hemorrhage].
abstract: OBJECTIVE
  To evaluate functional and anatomic results of intravitreal bevacizumab as monotherapy at 12 and 24 months in patients with neovascular age-related macular degeneration (AMD) complicated by large submacular hemorrhage.
  
  
  METHODS
  Retrospective analysis of a total of 21 patients (22 eyes) with large submacular hemorrhage secondary to age-related macular degeneration between May 2008 and December 2011. Patients were treated with three monthly intravitreal bevacizumab injections (1.25mg/0.05 mL) at a four to six week interval and then PRN. Retreatment was based on the presence of hemorrhage on fundus examination or signs of activity on optical coherence tomography. Changes from baseline best corrected visual acuity (BCVA) scores, central retinal thickness, volume of hemorrhage and number of injections were analyzed.
  
  
  RESULTS
  The mean patient age was 72 years (range, 60-89 years). All patients completed at least 12 months of follow-up, and 17 patients fulfilled 24 months. The size of hemorrhage varied from 3 to 9 disc areas with a mean duration of 12.8 days. At baseline, mean initial BCVA was 20/400 (1.3 LogMAR) and improved to 20/160 at 12 months (P<0.001) and 20/164 at 24 months (P<0.001). Mean central retinal thickness decreased significantly from 550 μm to 255 μm at 24 months (P<0.001). The mean number of injections was 3.87 during the first 12 months. No case of recurrent bleeding was detected during the second year.
  
  
  CONCLUSIONS
  Intravitreal bevacizumab may be a beneficial approach for the management of large submacular hemorrhage secondary to AMD.
authors.affiliation: Service d'ophtalmologie B, institut Hédi Rais, boulevard 9 Avril, 1006 Tunis, Tunisie; Faculté de médecine de Tunis, université Tunis El Manar, El Manar 1, Tunisie. Electronic address: rimbouraoui28@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Bouraoui
authors.affiliation: Service d'ophtalmologie B, institut Hédi Rais, boulevard 9 Avril, 1006 Tunis, Tunisie; Faculté de médecine de Tunis, université Tunis El Manar, El Manar 1, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Bouladi
authors.affiliation: Service d'ophtalmologie B, institut Hédi Rais, boulevard 9 Avril, 1006 Tunis, Tunisie; Faculté de médecine de Tunis, université Tunis El Manar, El Manar 1, Tunisie.
authors.forename: F
authors.initials: F
authors.lastname: Kort
authors.affiliation: Service d'ophtalmologie B, institut Hédi Rais, boulevard 9 Avril, 1006 Tunis, Tunisie; Faculté de médecine de Tunis, université Tunis El Manar, El Manar 1, Tunisie.
authors.forename: R
authors.initials: R
authors.lastname: Limaiem
authors.affiliation: Service d'ophtalmologie B, institut Hédi Rais, boulevard 9 Avril, 1006 Tunis, Tunisie; Faculté de médecine de Tunis, université Tunis El Manar, El Manar 1, Tunisie.
authors.forename: F
authors.initials: F
authors.lastname: Mghaieth
authors.affiliation: Service d'ophtalmologie B, institut Hédi Rais, boulevard 9 Avril, 1006 Tunis, Tunisie; Faculté de médecine de Tunis, université Tunis El Manar, El Manar 1, Tunisie.
authors.forename: L
authors.initials: L
authors.lastname: El Matri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000068258:Bevacizumab / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008268:Macular Degeneration / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012166:Retinal Hemorrhage / Q000150:complications / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D000068258:Bevacizumab
keywords: Age-related macular degeneration; Bevacizumab; Dégénérescence maculaire liée à l’âge; Hémorragies sous maculaires; Injections intravitréennes d’anti-VEGF; Intravitreal anti-VEGF injections; Submacular haemorrhage