title: [Potentiation strategies].
abstract: Lithium is among the most classically recommended add-on therapeutic strategy for the management of depressive patients showing unsuccessful response to standard antidepressant medications. The effectiveness of the add-on strategy with lithium requires achieving plasma levels above 0.5 mEq/L. Mood-stabilizing antiepileptic drugs such as carbamazepine, valproate derivatives or lamotrigine have not demonstrated conclusive therapeutic effects for the management of depressive patients showing unsuccessful response to standard antidepressant medications. Thyroid hormones are considered among the currently recommended add-on therapeutic strategy for the management of depressive patients showing unsuccessful response to standard antidepressant medications. The effectiveness of the add-on strategy with thyroid hormones requires achieving plasma concentration of TSH close to the lower limits at the normal range (0.4 μUI/L) or even below it. Second-generation antipsychotics such as aripiprazole or quetiapine have consistently demonstrated significant therapeutic effects for the management of depressive patients showing unsuccessful response to standard antidepressant medications. Second-generation antipsychotics however require the careful monitoring of both cardiovascular and metabolic adverse effects.
authors.affiliation: Centre expert Dépression résistante FondaMental, CH Charles-Perrens, Pôle de Psychiatrie générale et universitaire, 33076 Bordeaux cedex, France. Electronic address: odoumy@ch-perrens.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Doumy
authors.affiliation: Centre expert Dépression résistante FondaMental, CHU de Besançon, Service de Psychiatrie de l'Adulte, 25030 Besançon cedex, France.
authors.forename: Djamila
authors.initials: D
authors.lastname: Bennabi
authors.affiliation: Centre expert Dépression résistante FondaMental, CHU de Tours, Clinique Psychiatrique Universitaire, 37044 Tours cedex 9, France.
authors.forename: Wissam
authors.initials: W
authors.lastname: El-Hage
authors.affiliation: Centre expert Dépression résistante FondaMental, hôpital Fernand-Widal, Service de Psychiatrie Adulte, 75010 Paris, France.
authors.forename: Najib
authors.initials: N
authors.lastname: Allaïli
authors.affiliation: Centre expert Dépression résistante FondaMental, Centre Hospitalier Le Vinatier, Service Universitaire de Psychiatrie Adulte, BP 300 39, 69678 Bron cedex, France.
authors.forename: Rémy
authors.initials: R
authors.lastname: Bation
authors.affiliation: Centre expert Dépression résistante FondaMental, hôpital Fernand-Widal, Service de Psychiatrie Adulte, 75010 Paris, France.
authors.forename: Frank
authors.initials: F
authors.lastname: Bellivier
authors.affiliation: Centre expert Dépression résistante FondaMental, Hôpital Nord, CHU de Grenoble, Service de Psychiatrie de l'adulte, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Holtzmann
authors.affiliation: Centre expert Dépression résistante FondaMental, hôpital Fontan 1, CHRU de Lille, Service de Psychiatrie Adulte, 59037 Lille cedex, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Bubrovszky
authors.affiliation: Centre expert Dépression résistante FondaMental, CHU de Tours, Clinique Psychiatrique Universitaire, 37044 Tours cedex 9, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Camus
authors.affiliation: Centre expert Dépression résistante FondaMental, CHU de Clermont-Ferrand, Service de Psychiatrie de l'adulte B, 63003 Clermont-Ferrand, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Charpeaud
authors.affiliation: Centre expert Dépression résistante FondaMental, Hôpital Nord, CHU de Grenoble, Service de Psychiatrie de l'adulte, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Courvoisier
authors.affiliation: Centre expert Dépression résistante FondaMental, Centre Hospitalier Le Vinatier, Service Universitaire de Psychiatrie Adulte, BP 300 39, 69678 Bron cedex, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: d'Amato
authors.affiliation: Centre expert Dépression résistante FondaMental, CHU de Clermont-Ferrand, Service de Psychiatrie de l'adulte B, 63003 Clermont-Ferrand, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Garnier
authors.affiliation: Centre expert Dépression résistante FondaMental, Centre Hospitalier Le Vinatier, Service Universitaire de Psychiatrie Adulte, BP 300 39, 69678 Bron cedex, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Haesebaert
authors.affiliation: Centre expert Dépression résistante FondaMental, Hôpital Nord, CHU de Grenoble, Service de Psychiatrie de l'adulte, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Bougerol
authors.affiliation: Centre expert Dépression résistante FondaMental, CHU La Conception, Pôle Psychiatrie Centre, 13005 Marseille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Lançon
authors.affiliation: Centre expert Dépression résistante FondaMental, Département des urgences et post-urgences psychiatrique, CHRU Lapeyronie, 34295 Montpellier cedex 5, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Moliere
authors.affiliation: Centre expert Dépression résistante FondaMental, hôpital Fernand-Widal, Service de Psychiatrie Adulte, 75010 Paris, France.
authors.forename: Isabel
authors.initials: I
authors.lastname: Nieto
authors.affiliation: Centre expert Dépression résistante FondaMental, CHU La Conception, Pôle Psychiatrie Centre, 13005 Marseille, France.
authors.forename: Raphaëlle
authors.initials: R
authors.lastname: Richieri
authors.affiliation: Centre expert Dépression résistante FondaMental, Pôle de Psychiatrie des hôpitaux universitaires, Henri-Mondor, Hôpital Chenevier, 94000 Créteil, France.
authors.forename: Ghassen
authors.initials: G
authors.lastname: Saba
authors.affiliation: Centre expert Dépression résistante FondaMental, Département des urgences et post-urgences psychiatrique, CHRU Lapeyronie, 34295 Montpellier cedex 5, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Courtet
authors.affiliation: Centre expert Dépression résistante FondaMental, hôpital Fontan 1, CHRU de Lille, Service de Psychiatrie Adulte, 59037 Lille cedex, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Vaiva
authors.affiliation: Centre expert Dépression résistante FondaMental, Pôle de Psychiatrie des hôpitaux universitaires, Henri-Mondor, Hôpital Chenevier, 94000 Créteil, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
authors.affiliation: Centre expert Dépression résistante FondaMental, CHU de Clermont-Ferrand, Service de Psychiatrie de l'adulte B, 63003 Clermont-Ferrand, France.
authors.forename: Pierre-Michel
authors.initials: PM
authors.lastname: Llorca
authors.affiliation: Centre expert Dépression résistante FondaMental, CH Charles-Perrens, Pôle de Psychiatrie générale et universitaire, 33076 Bordeaux cedex, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Aouizerate
authors.affiliation: Centre expert Dépression résistante FondaMental, CHU de Besançon, Service de Psychiatrie de l'Adulte, 25030 Besançon cedex, France.
authors.forename: Emmanuel
authors.initials: E
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mesh_terms: D000927:Anticonvulsants / Q000493:pharmacokinetics / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000145:classification / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D004351:Drug Resistance; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D016651:Lithium Carbonate / Q000493:pharmacokinetics / Q000627:therapeutic use; D015201:Meta-Analysis as Topic; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D013963:Thyroid Hormones / Q000493:pharmacokinetics / Q000627:therapeutic use; D013972:Thyrotropin / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D013963:Thyroid Hormones; D016651:Lithium Carbonate; D013972:Thyrotropin