title: Germ Plasm Biogenesis--An Oskar-Centric Perspective.
abstract: Germ granules are the hallmark of all germ cells. These membrane-less, electron-dense structures were first observed over 100 years ago. Today, their role in regulating and processing transcripts critical for the establishment, maintenance, and protection of germ cells is well established, and pathways outlining the biochemical mechanisms and physical properties associated with their biogenesis are emerging.
authors.affiliation: Howard Hughes Medical Institute (HHMI), Department of Cell Biology, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, USA. Electronic address: ruth.lehmann@med.nyu.edu.
authors.forename: Ruth
authors.initials: R
authors.lastname: Lehmann
mesh_terms: D000818:Animals; D004330:Drosophila / Q000254:growth & development* / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000166:cytology* / Q000378:metabolism; D009865:Oocytes / Q000166:cytology* / Q000378:metabolism; D009866:Oogenesis / Q000502:physiology*
chemical_list: D029721:Drosophila Proteins; C091675:osk protein, Drosophila
keywords: Drosophila; Germ cells; Germ granules; Germ plasm; Nanos; Nuage; Oskar; Phase transition; RNA granules; RNA localization; RNA translation; Tudor; Vasa