title: Luteinizing hormone-releasing hormone peptide tethered nanoparticulate system for enhanced antitumoral efficacy of paclitaxel.
abstract: OBJECTIVE
  Paclitaxel (PTX) is an effective anticancer agent used in the therapy of a wide variety of cancers. However, the drug is difficult to formulate due to its low solubility, and therefore, it is administered under slow infusion with castor oil/ethanol solution as surfactant that causes serious side effects. This investigation investigates leutinizing hormone releasing hormone (LHRH)-tethered nanparticulate system as modality for cancer-specific delivery of PTX and therefore minimizing the adverse effects.
  
  
  METHODS
  LHRH-tethered poly(lactic-co-glycolic acid) copolymer with poly ethylene glycol side chain was synthesized, characterized and employed to formulate PTX-loaded nanoparticulate system.
  
  
  CONCLUSIONS
  The developed nanoparticulate appears to be proficient in carrying as well as targeted delivery of PTX with improved therapeutic efficacy and better safety.
authors.affiliation: Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar 470003 MP, India.
authors.forename: Raksha
authors.initials: R
authors.lastname: Ghanghoria
authors.affiliation: The University of Texas Southwestern Medical Center, Advanced Imaging Research Centre, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.|The International Medical University, School of Pharmacy, Department of Pharmaceutical Technology, Jalan Jalil Perkasa 19, 57000 Kuala Lumpur, Malaysia.
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Tekade
authors.affiliation: Division of Cyclotron & Radiopharmaceutical Sciences, Molecular Imaging Research Center, Institute of Nuclear Medicine & Allied Sciences (INMAS), DRDO, 110054 Delhi, India.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Mishra
authors.affiliation: Division of Cyclotron & Radiopharmaceutical Sciences, Molecular Imaging Research Center, Institute of Nuclear Medicine & Allied Sciences (INMAS), DRDO, 110054 Delhi, India.
authors.forename: Krishna
authors.initials: K
authors.lastname: Chuttani
authors.affiliation: Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar 470003 MP, India.
authors.forename: Narendra Kumar
authors.initials: NK
authors.lastname: Jain
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001940:Breast / Q000187:drug effects* / Q000473:pathology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000737:chemistry*; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D061986:MCF-7 Cells; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry; D017239:Paclitaxel / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D007987:Gonadotropin-Releasing Hormone; D019344:Lactic Acid; D011092:Polyethylene Glycols; D017239:Paclitaxel
keywords: LHRH; PLGA copolymer; biodistribution; cancer targeting; paclitaxel; pharmacodynamics; pharmacokinetics