title: Bolus arrival time and its effect on tissue characterization with dynamic contrast-enhanced magnetic resonance imaging.
abstract: Matching the bolus arrival time (BAT) of the arterial input function (AIF) and tissue residue function (TRF) is necessary for accurate pharmacokinetic (PK) modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). We investigated the sensitivity of volume transfer constant ([Formula: see text]) and extravascular extracellular volume fraction ([Formula: see text]) to BAT and compared the results of four automatic BAT measurement methods in characterization of prostate and breast cancers. Variation in delay between AIF and TRF resulted in a monotonous change trend of [Formula: see text] and [Formula: see text] values. The results of automatic BAT estimators for clinical data were all comparable except for one BAT estimation method. Our results indicate that inaccuracies in BAT measurement can lead to variability among DCE-MRI PK model parameters, diminish the quality of model fit, and produce fewer valid voxels in a region of interest. Although the selection of the BAT method did not affect the direction of change in the treatment assessment cohort, we suggest that BAT measurement methods must be used consistently in the course of longitudinal studies to control measurement variability.
authors.affiliation: Brigham and Women's Hospital, Department of Radiology, Surgical Planning Laboratory, ASBI, L1-050, 75 Francis Street, Boston, Massachusetts 02115, United States; Harvard Medical School, Boston, Massachusetts 02115, United States.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mehrtash
authors.affiliation: General Electric Global Research , Niskayuna, New York 12309, United States.
authors.forename: Sandeep N
authors.initials: SN
authors.lastname: Gupta
authors.affiliation: General Electric Global Research , Niskayuna, New York 12309, United States.
authors.forename: Dattesh
authors.initials: D
authors.lastname: Shanbhag
authors.affiliation: General Electric Global Research , Niskayuna, New York 12309, United States.
authors.forename: James V
authors.initials: JV
authors.lastname: Miller
authors.affiliation: Brigham and Women's Hospital, Department of Radiology, Surgical Planning Laboratory, ASBI, L1-050, 75 Francis Street, Boston, Massachusetts 02115, United States; Harvard Medical School, Boston, Massachusetts 02115, United States.
authors.forename: Tina
authors.initials: T
authors.lastname: Kapur
authors.affiliation: Brigham and Women's Hospital, Department of Radiology, Surgical Planning Laboratory, ASBI, L1-050, 75 Francis Street, Boston, Massachusetts 02115, United States; Harvard Medical School, Boston, Massachusetts 02115, United States; Dana Farber Cancer Institute, Department of Radiology, Boston, Massachusetts 02115, United States.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Fennessy
authors.affiliation: Brigham and Women's Hospital, Department of Radiology, Surgical Planning Laboratory, ASBI, L1-050, 75 Francis Street, Boston, Massachusetts 02115, United States; Harvard Medical School, Boston, Massachusetts 02115, United States.
authors.forename: Ron
authors.initials: R
authors.lastname: Kikinis
authors.affiliation: Brigham and Women's Hospital, Department of Radiology, Surgical Planning Laboratory, ASBI, L1-050, 75 Francis Street, Boston, Massachusetts 02115, United States; Harvard Medical School, Boston, Massachusetts 02115, United States.
authors.forename: Andriy
authors.initials: A
authors.lastname: Fedorov
keywords: Tofts model; bolus arrival time; dynamic contrast-enhanced magnetic resonance imaging; pharmacokinetic analysis; quantitative imaging; reproducibly