title: [CELIAC DISEASE].
abstract: Celiac disease is an inflammatory enteropathy, autoimmune-like, due to gluten intake in genetically predisposed persons with HLA-DQ2/DQ8 genotyping. Prevalence rates are approaching 1% of population in Europe and USA. Clinical expression of celiac disease is extremely various. Screening is based on detection of serum celiac antibodies and diagnosis is confirmed with duodenal biopsy. Treatment relies on gluten free diet (GFD) with eviction of wheat, barley and rye. GFD allows prevention of osteopenia, autoimmune diseases and malignant complications. The main cause of resistance to GFD because is its bad observance.
authors.forename: Georgia
authors.initials: G
authors.lastname: Malamut
authors.forename: Christophe
authors.initials: C
authors.lastname: Cellier
mesh_terms: D000906:Antibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis* / Q000178:diet therapy* / Q000235:genetics / Q000276:immunology; D055050:Diet, Gluten-Free; D005060:Europe / Q000453:epidemiology; D005602:France / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000097:blood; D006801:Humans; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D000906:Antibodies; D015415:Biomarkers; D006683:HLA-DQ Antigens; C109756:HLA-DQ8 antigen