title: Inhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II.
abstract: New phenolic mono and bis Mannich bases incorporating benzimidazole, such as 2-(aminomethyl)-4-(1H-benzimidazol-2-yl)phenol and 2,6-bis(aminomethyl)-4-(1H-benzimidazol-2-yl)phenol were synthesized starting from 4-(1H-benzimidazol-2-yl)phenol. Amines used for the synthesis included dimethylamine, pyrrolidine, piperidine, N-methylpiperazine and morpholine. The CA inhibitory properties of these compounds were tested on the human carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I and hCA II. These new compounds, as many phenols show moderate CA inhibitory properties.
authors.affiliation: a Department of Pharmaceutical Chemistry , Faculty of Pharmacy, Ataturk University , Erzurum , Turkey and.
authors.forename: Halise Inci
authors.initials: HI
authors.lastname: Gul
authors.affiliation: a Department of Pharmaceutical Chemistry , Faculty of Pharmacy, Ataturk University , Erzurum , Turkey and.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Yazici
authors.affiliation: b Neurofarba Department e Laboratorio di Chimica Bioinorganica, Universita Degli Studi di Firenze , SestoFiorentino (Florence) , Italy.
authors.forename: Muhammet
authors.initials: M
authors.lastname: Tanc
authors.affiliation: b Neurofarba Department e Laboratorio di Chimica Bioinorganica, Universita Degli Studi di Firenze , SestoFiorentino (Florence) , Italy.
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D024401:Carbonic Anhydrase I / Q000378:metabolism*; D024402:Carbonic Anhydrase II / Q000378:metabolism*; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology*; D006801:Humans; D008352:Mannich Bases / Q000737:chemistry*; D010636:Phenols / Q000494:pharmacology*; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D001562:Benzimidazoles; D002257:Carbonic Anhydrase Inhibitors; D008352:Mannich Bases; D010636:Phenols; D024401:Carbonic Anhydrase I; D024402:Carbonic Anhydrase II
keywords: Benzimidazole; Mannich bases; carbonic anhydrase; enzyme inhibition; phenol