title: Catalytic Difluorination of Olefins.
abstract: Molecular editing with fluorine is a validated strategy for modulating the structure and function of organic systems. In the current arsenal of catalytic dihalogenation technologies, the direct generation of the vicinal difluoride moiety from simple olefins without a prefunctionalization step remains conspicuously absent. Herein we report a catalytic, vicinal difluorination of olefins displaying broad functional group tolerance, using inexpensive p-iodotoluene as the catalyst. Preliminary efforts toward the development of an enantioselective variant are also disclosed.
authors.affiliation: Institute for Organic Chemistry, Westfälische Wilhelms-Universität Münster , Corrensstrasse 40, 48149 Münster, Germany.
authors.forename: István Gábor
authors.initials: IG
authors.lastname: Molnár
authors.affiliation: Institute for Organic Chemistry, Westfälische Wilhelms-Universität Münster , Corrensstrasse 40, 48149 Münster, Germany.
authors.forename: Ryan
authors.initials: R
authors.lastname: Gilmour