title: Cyclopenta[b]benzofuran and Secodammarane Derivatives from the Stems of Aglaia stellatopilosa.
abstract: Four new 2,3-secodammarane triterpenoids, stellatonins A-D (3-6), together with a new 3,4-secodammarane triterpenoid, stellatonin E (7), and the known silvestrol (1), 5‴-episilvestrol (2), and β-sitosterol, were isolated from a methanol extract of the stems of Aglaia stellatopilosa through bioassay-guided fractionation. The structures of the new compounds were elucidated using spectroscopic and chemical methods. The compounds were evaluated for their cytotoxic activity against three human cancer cell lines and for their antimicrobial activity using a microtiter plate assay against a panel of Gram-positive and Gram-negative bacteria and fungi.
authors.affiliation: Sarawak Biodiversity Centre , KM20, Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, Kuching 93990, Sarawak Malaysia.
authors.forename: Nuraqilah
authors.initials: N
authors.lastname: Othman
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio 43210, United States.
authors.forename: Li
authors.initials: L
authors.lastname: Pan
authors.affiliation: Sarawak Biodiversity Centre , KM20, Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, Kuching 93990, Sarawak Malaysia.
authors.forename: Michele
authors.initials: M
authors.lastname: Mejin
authors.affiliation: Sarawak Biodiversity Centre , KM20, Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, Kuching 93990, Sarawak Malaysia.
authors.forename: Julian C L
authors.initials: JC
authors.lastname: Voong
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio 43210, United States.
authors.forename: Hee-byung
authors.initials: HB
authors.lastname: Chai
authors.affiliation: Department of Plant Sciences, University of Oxford , South Parks Road, Oxford OX1 3RB, United Kingdom.
authors.forename: Caroline M
authors.initials: CM
authors.lastname: Pannell
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio 43210, United States.
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
authors.affiliation: Sarawak Biodiversity Centre , KM20, Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, Kuching 93990, Sarawak Malaysia.
authors.forename: Tiong C
authors.initials: TC
authors.lastname: Yeo
mesh_terms: D031602:Aglaia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D019073:HT29 Cells; D006801:Humans; D008296:Malaysia; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012855:Sitosterols; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000097669:Dammaranes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D012855:Sitosterols; D014315:Triterpenes; D000097669:Dammaranes; C489893:episilvestrol; C489897:silvestrol; C000610474:stellatonin E; C025473:gamma-sitosterol