title: Serum Fatty Acids, Traditional Risk Factors, and Comorbidity as Related to Myocardial Injury in an Elderly Population with Acute Myocardial Infarction.
abstract: Background. Epidemiological and randomized clinical trials indicate that marine polyunsaturated n-3 fatty acids (n-3 PUFAs) may have cardioprotective effects. Aim. Evaluate the associations between serum fatty acid profile, traditional risk factors, the presence of cardiovascular diseases (CVD), and peak Troponin T (TnT) levels in elderly patients with an acute myocardial infarction (AMI). Materials and Methods. Patients (n = 299) consecutively included in the ongoing Omega-3 fatty acids in elderly patients with myocardial infarction (OMEMI) trial were investigated. Peak TnT was registered during the hospital stay. Serum fatty acid analysis was performed 2-8 weeks later. Results. No significant correlations between peak TnT levels and any of the n-3 PUFAs were observed. However, patients with a history of atrial fibrillation had significantly lower docosahexaenoic acid levels than patients without. Significantly lower peak TnT levels were observed in patients with a history of hyperlipidemia, angina, MI, atrial fibrillation, intermittent claudication, and previous revascularization (all p < 0.02). Conclusions. In an elderly population with AMI, no association between individual serum fatty acids and estimated myocardial infarct size could be demonstrated. However, a history of hyperlipidemia and the presence of CVD were associated with lower peak TnT levels, possibly because of treatment with cardioprotective medications.
authors.affiliation: Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ullevål, 0450 Oslo, Norway; Faculty of Medicine, University of Oslo, 0316 Oslo, Norway; Center for Heart Failure Research, University of Oslo, 0316 Oslo, Norway.
authors.forename: Kristian
authors.identifier: 0000-0003-2925-0823
authors.initials: K
authors.lastname: Laake
authors.affiliation: Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ullevål, 0450 Oslo, Norway; Faculty of Medicine, University of Oslo, 0316 Oslo, Norway; Center for Heart Failure Research, University of Oslo, 0316 Oslo, Norway.
authors.forename: Ingebjørg
authors.initials: I
authors.lastname: Seljeflot
authors.affiliation: Department of Cardiology, Aalborg University Hospital, 9000 Aalborg, Denmark.
authors.forename: Erik B
authors.initials: EB
authors.lastname: Schmidt
authors.affiliation: Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ullevål, 0450 Oslo, Norway; Center for Heart Failure Research, University of Oslo, 0316 Oslo, Norway; Department of Cardiology, Akershus University Hospital HF, 1478 Lørenskog, Norway.
authors.forename: Peder
authors.initials: P
authors.lastname: Myhre
authors.affiliation: Department of Medical Research, Vestre Viken Hospital Trust, Bærum Hospital, 1346 Rud, Norway.
authors.forename: Arnljot
authors.initials: A
authors.lastname: Tveit
authors.affiliation: Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ullevål, 0450 Oslo, Norway; Faculty of Medicine, University of Oslo, 0316 Oslo, Norway; Center for Heart Failure Research, University of Oslo, 0316 Oslo, Norway.
authors.forename: Harald
authors.initials: H
authors.lastname: Arnesen
authors.affiliation: Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ullevål, 0450 Oslo, Norway; Center for Heart Failure Research, University of Oslo, 0316 Oslo, Norway.
authors.forename: Svein
authors.identifier: 0000-0003-3321-6572
authors.initials: S
authors.lastname: Solheim