title: Universal features of fluctuations in globular proteins.
abstract: Using data from 2000 non-homologous protein crystal structures, we show that the distribution of residue B factors of proteins collapses onto a single master curve. We show by maximum entropy arguments that this curve is a Gamma function whose order and dispersion are obtained from experimental data. The distribution for any given specific protein can be generated from the master curve by a linear transformation. Any perturbation of the B factor distribution of a protein, imposed at constant energy, causes a decrease in the entropy of the protein relative to that of the reference state. Proteins 2016; 84:721-725. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Chemical and Biological Engineering Department, Koc University, Istanbul, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Erman
mesh_terms: D000465:Algorithms; D000818:Animals; D030562:Databases, Protein; D019277:Entropy; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins
keywords: B factors; Gaussian network model; distribution of fluctuations; entropy change; gamma function; residue fluctuations