title: Piperidine derivatives as nonprostanoid IP receptor agonists.
abstract: The discovery of a new class of nonprostanoid prostaglandin I2 receptor (IP receptor) agonists is reported. Among them, the unique piperidine derivative 31b (2-((1-(2-(N-(4-tolyl)benzamido)ethyl)piperidin-4-yl)oxy)acetic acid) was a good IP receptor agonist and was 50-fold more selective for the human IP receptor than for other human prostanoid receptors. This compound showed good pharmacokinetic properties in dog.
authors.affiliation: Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan. Electronic address: Ryoji_Hayashi2@nts.toray.co.jp.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Hayashi
authors.affiliation: Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Sakagami
authors.affiliation: Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Koiwa
authors.affiliation: Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ito
authors.affiliation: Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan.
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Miyamoto
authors.affiliation: Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Isogaya
mesh_terms: D000818:Animals; D004285:Dogs; D006801:Humans; D010880:Piperidines / Q000494:pharmacology*; D044006:Receptors, Epoprostenol / Q000819:agonists*
chemical_list: D010880:Piperidines; D044006:Receptors, Epoprostenol
keywords: Agonist; Benzanilide; IP; Nonprostanoid; Piperidine; Prostacyclin