title: Taking the Broad View on B Cell Affinity Maturation.
abstract: Germinal center (GC) responses are required for the generation of high-affinity antigen-specific B cells. Kuraoka et al. (2016) explore the importance of inter-clonal competition in GC affinity maturation through the use of complex immunizing antigens and discover an unexpected increase in clonal diversity over the course of the response.
authors.affiliation: Committee on Immunology, The Knapp Center of Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA.
authors.forename: Karlynn E
authors.initials: KE
authors.lastname: Neu
authors.affiliation: Committee on Immunology, The Knapp Center of Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA; The Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. Electronic address: wilsonp@uchicago.edu.
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Wilson
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D060966:Clonal Selection, Antigen-Mediated; D005260:Female; D018858:Germinal Center / Q000276:immunology*; D006801:Humans; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*
chemical_list: D011947:Receptors, Antigen, B-Cell