title: Primary lung tumors in children: 24 years of experience at a referral center.
abstract: OBJECTIVE
  Primary lung tumors are rare during childhood and encompass a wide variety of histological types. Each has a different biology and a different therapeutic approach. The aim of this article is to review the experience of a pediatric referral center with this kind of tumors during the last 24 years.
  
  
  METHODS
  A retrospective chart review was performed for patients with diagnosis of primary lung tumor between the years 1990-2014. The variables analyzed were age, sex, course of the disease, symptoms, localization, surgery, histology and outcome.
  
  
  RESULTS
  Between 1990 and 2014, 38 patients with primary lung tumors were treated at our institution. Age at presentation was 6.6 ± 5.2 years (r 0.91-16.58) and the female:male relationship was 1.37. Inflammatory myofibroblastic lung tumor (n = 13), carcinoid tumor (n = 6) and pleuropulmonary blastoma (n = 6) were the most frequent histological types. Persistent radiographic abnormality was the most frequent presenting sign (34 %). Global mortality was 15.8 % varying according to histology.
  
  
  CONCLUSIONS
  Although the diagnosis of primary lung tumor is rare, the persistence of a radiographic abnormality in spite of adequate treatment for inflammatory processes forces us to evaluate further. The age of the patient is an important factor in the decision of the diagnostic work-up.
authors.affiliation: Department of General Surgery, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina. giuse26@gmail.com.
authors.forename: Carlos
authors.identifier: http://orcid.org/0000-0001-8112-6817
authors.initials: C
authors.lastname: Giuseppucci
authors.affiliation: Department of General Surgery, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina.
authors.forename: Aixa
authors.initials: A
authors.lastname: Reusmann
authors.affiliation: Department of Pulmonology, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina.
authors.forename: Verónica
authors.initials: V
authors.lastname: Giubergia
authors.affiliation: Department of Pulmonology, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina.
authors.forename: Carolina
authors.initials: C
authors.lastname: Barrias
authors.affiliation: Department of Pulmonology, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina.
authors.forename: Anahi
authors.initials: A
authors.lastname: Krüger
authors.affiliation: Department of Pathology, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina.
authors.forename: Mónica
authors.initials: M
authors.lastname: Siminovich
authors.affiliation: Department of Endoscopy, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina.
authors.forename: Hugo
authors.initials: H
authors.lastname: Botto
authors.affiliation: Department of General Surgery, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina.
authors.forename: Martin
authors.initials: M
authors.lastname: Cadario
authors.affiliation: Department of General Surgery, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina.
authors.forename: Mariano
authors.initials: M
authors.lastname: Boglione
authors.affiliation: Department of General Surgery, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina.
authors.forename: Julieta
authors.initials: J
authors.lastname: Strambach
authors.affiliation: Department of General Surgery, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Barrenechea
mesh_terms: D000293:Adolescent; D002276:Carcinoid Tumor / Q000175:diagnosis / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis / Q000601:surgery; D018202:Pulmonary Blastoma / Q000175:diagnosis / Q000601:surgery; D012017:Referral and Consultation; D012189:Retrospective Studies
keywords: Carcinoid tumor; Lung; Myofibroblastic lung tumor; Pediatric; Tumor