title: Neuroendocrine Neoplasms of the Ovary: A Retrospective Study of the North Eastern German Society of Gynecologic Oncology (NOGGO).
abstract: OBJECTIVE
  Neuroendocrine neoplasms (NEN) of the female genital tract account for 2% of gynecological cancers. The aim of this study was to share our experience of 11 primary neuroendocrine neoplasms of the ovary.
  
  
  METHODS
  All patients who presented and/or were treated at our Institution with histologically-confirmed NEN of the ovary were included. Clinical data including tumor stage, diagnostic and therapeutic management and survival were assessed. Pathological specimens were critically reviewed.
  
  
  RESULTS
  We identified 11 patients with NEN of the ovary consisting of nine neuroendocrine cancers and two carcinoids. Median age was 55.9 years. NEN were mostly poorly differentiated (72.4%). Primary surgery was performed in all patients. Adjuvant chemotherapy was administered in five patients consisting of platinum-based regimens. Median overall survival was 20 months.
  
  
  CONCLUSIONS
  We propose a diagnostic algorithm for NEN of the ovary and discuss possible treatments according to FIGO stages. Patients should be included in multicenter studies whenever possible.
authors.affiliation: European Competence Center of Ovarian Cancer, Department of Gynecology, Charité University Medicine Berlin, Berlin, Germany.
authors.forename: Jalid
authors.initials: J
authors.lastname: Sehouli
authors.affiliation: European Competence Center of Ovarian Cancer, Department of Gynecology, Charité University Medicine Berlin, Berlin, Germany.
authors.forename: Hannah
authors.initials: H
authors.lastname: Woopen
authors.affiliation: Department of Gastroenterology and Hepatology, Charité University Medicine Berlin, Berlin, Germany.
authors.forename: Marianne
authors.initials: M
authors.lastname: Pavel
authors.affiliation: European Competence Center of Ovarian Cancer, Department of Gynecology, Charité University Medicine Berlin, Berlin, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Richter
authors.affiliation: European Competence Center of Ovarian Cancer, Department of Gynecology, Charité University Medicine Berlin, Berlin, Germany.
authors.forename: Lisa-Kathrin
authors.initials: LK
authors.lastname: Lauterbach
authors.affiliation: Institute of Pathology, Charité University Medicine Berlin, Berlin, Germany.
authors.forename: Eliane
authors.initials: E
authors.lastname: Taube
authors.affiliation: Institute of Pathology, Charité University Medicine Berlin, Berlin, Germany.
authors.forename: Silvia
authors.initials: S
authors.lastname: Darb-Esfahani
authors.affiliation: Ovarian Cancer Centre and Ovarian Cancer Action Research Centre, Imperial College Healthcare Trust London, Hammersmith Campus, London, U.K.
authors.forename: Christina
authors.initials: C
authors.lastname: Fotopoulou
authors.affiliation: European Competence Center of Ovarian Cancer, Department of Gynecology, Charité University Medicine Berlin, Berlin, Germany klaus.pietzner@charite.de.
authors.forename: Klaus
authors.initials: K
authors.lastname: Pietzner
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
keywords: Neuroendocrine cancer; ovarian; treatment algorithm