title: The impact of epilepsy on the quality of life of patients with meningioma: A systematic review.
abstract: Quality of life (QoL) is regarded as an important outcome measure in meningioma, and studies have investigated the role of various clinical and demographic factors. Epilepsy is known to impair quality of life but the impact of epilepsy on quality of life in a meningioma population is not well defined. The aim of this systematic review is to identify and summarise the current literature on meningioma, epilepsy and quality of life. A PubMed search was performed that identified 162 articles. Only 4 articles relevant to meningioma, epilepsy and QoL were found and each were analysed in terms of design, data, findings and conclusions. Each article was different in terms of study population, aims and outcome measure, but all suggest that epilepsy has an impact on quality of life. Anti-epileptic drugs, uncontrolled seizures and cognitive dysfunction may be particularly significant. The identified articles were weakened by small sample size, short follow-up, a lack of recorded epilepsy variables and the use of quality of life measures that are either too specific or not validated. Future studies are warranted to improve understanding in this topic, aid clinical decisions and improve QoL in these patients.
authors.affiliation: a The Walton Centre NHS Foundation Trust , Lower Lane, Fazakerley, Liverpool , UK.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Tanti
authors.affiliation: a The Walton Centre NHS Foundation Trust , Lower Lane, Fazakerley, Liverpool , UK.|b Institute of Translational Medicine, University of Liverpool , Liverpool , UK.
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Marson
authors.affiliation: a The Walton Centre NHS Foundation Trust , Lower Lane, Fazakerley, Liverpool , UK.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Chavredakis
authors.affiliation: a The Walton Centre NHS Foundation Trust , Lower Lane, Fazakerley, Liverpool , UK.|b Institute of Translational Medicine, University of Liverpool , Liverpool , UK.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Jenkinson
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D004827:Epilepsy / Q000150:complications / Q000523:psychology* / Q000628:therapy; D006801:Humans; D008577:Meningeal Neoplasms / Q000150:complications / Q000523:psychology* / Q000628:therapy; D008579:Meningioma / Q000150:complications / Q000523:psychology* / Q000628:therapy; D017063:Outcome Assessment, Health Care; D011788:Quality of Life / Q000523:psychology*
chemical_list: D000927:Anticonvulsants
keywords: AEDs; brain tumour; epilepsy; meningioma; quality of life