title: Efficacy of phytosterols and fish-oil supplemented high-oleic-sunflower oil rich diets in hypercholesterolemic growing rats.
abstract: Phytosterols (P) and fish-oil (F) efficacy on high-oleic-sunflower oil (HOSO) diets were assessed in hypercholesterolemic growing rats. Controls (C) received a standard diet for 8 weeks; experimental rats were fed an atherogenic diet (AT) for 3 weeks, thereafter were divided into four groups fed for 5 weeks a monounsaturated fatty acid diet (MUFA) containing either: extra virgin olive oil (OO), HOSO or HOSO supplemented with P or F. The diets did not alter body weight or growth. HOSO-P and HOSO-F rats showed reduced total cholesterol (T-chol), non-high-density lipoprotein-cholesterol (non-HDL-chol) and triglycerides and increased HDL-chol levels, comparably to the OO rats. Total body fat (%) was similar among all rats; but HOSO-F showed the lowest intestinal, epididymal and perirenal fat. However, bone mineral content and density, and bone yield stress and modulus of elasticity were unchanged. Growing hypercholesterolemic rats fed HOSO with P or F improved serum lipids and fat distribution, but did not influence material bone quality.
authors.affiliation: a Department of Biochemistry, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina ;
authors.forename: Estefania
authors.initials: E
authors.lastname: Alsina
authors.affiliation: a Department of Biochemistry, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina ;
authors.forename: Elisa V
authors.initials: EV
authors.lastname: Macri
authors.affiliation: b Pediatric Sunshine Academics Inc , Santa Barbara , CA , USA ;
authors.forename: Fima
authors.initials: F
authors.lastname: Lifshitz
authors.affiliation: c Department of Physiology, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina ;
authors.forename: Clarisa
authors.initials: C
authors.lastname: Bozzini
authors.affiliation: a Department of Biochemistry, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina ;
authors.forename: Patricia N
authors.initials: PN
authors.lastname: Rodriguez
authors.affiliation: c Department of Physiology, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina ;
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Boyer
authors.affiliation: d Department of General and Oral Biochemistry, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina.
authors.forename: Silvia M
authors.initials: SM
authors.lastname: Friedman
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002079:Butter / Q000009:adverse effects; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004036:Diet, Atherogenic / Q000009:adverse effects; D059305:Diet, High-Fat / Q000009:adverse effects; D004042:Dietary Fats, Unsaturated / Q000009:adverse effects / Q000627:therapeutic use*; D019587:Dietary Supplements / Q000009:adverse effects; D005395:Fish Oils / Q000009:adverse effects / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy* / Q000209:etiology; D008297:Male; D019301:Oleic Acid / Q000009:adverse effects / Q000627:therapeutic use; D000069463:Olive Oil / Q000009:adverse effects / Q000627:therapeutic use; D010840:Phytosterols / Q000009:adverse effects / Q000627:therapeutic use*; D010938:Plant Oils / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation; D017208:Rats, Wistar; D000074242:Sunflower Oil; D014280:Triglycerides / Q000097:blood; D014886:Weaning
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D000069463:Olive Oil; D010840:Phytosterols; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides; D019301:Oleic Acid; D002079:Butter; D002784:Cholesterol
keywords: Body fat; bone quality; fish oil; high-oleic-sunflower oil; lipid profile; phytosterol; weight and growth gain