title: Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis.
abstract: Previous studies have examined the role of three NOS3 gene polymorphisms [G894T, T-786C, and the variable number of tandem repeats 4b/a (VNTR 4b/a)] in the susceptibility to preeclampsia with inconclusive findings. We therefore conducted an updated meta-analysis by including more studies. The most appropriate genetic model was chosen for each polymorphism by using a well-established method. Pooled results indicated that, compared with the GT+GG genotype, the TT genotype of G894T was associated with an increased risk of preeclampsia (odds ratio (OR) = 1.46; 95% confidence interval (CI) = 1.21-1.77, P < 0.001; I(2) = 40.2%). The CC genotype of T-786C was also associated with a higher risk of preeclampsia (OR = 1.30; 95% CI = 1.07-1.58, P = 0.034; I(2) = 46.9%) than the CT + TT genotype. No association was found for VNTR 4b/a. Stratified analysis indicated that the increased risk was evident for high-quality studies both for G894T and T-786C, and for studies conducted among Caucasians and Africans for T-786C. However, the increased risk for T-786C among Africans needs further confirmation due to the high probability of false-positive reports. Our results suggested that G894T and T-786C polymorphisms, but not VNTR 4b/a, were associated with an increased risk of preeclampsia.
authors.affiliation: School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.|CUHK Shenzhen Research Institute, Shenzhen 518057, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Zeng
authors.affiliation: Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Sichuan 610044, China.
authors.forename: Sui
authors.initials: S
authors.lastname: Zhu
authors.affiliation: School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.|CUHK Shenzhen Research Institute, Shenzhen 518057, China.
authors.forename: Martin Chi-Sang
authors.initials: MC
authors.lastname: Wong
authors.affiliation: School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.|CUHK Shenzhen Research Institute, Shenzhen 518057, China.
authors.forename: Zuyao
authors.initials: Z
authors.lastname: Yang
authors.affiliation: School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.|CUHK Shenzhen Research Institute, Shenzhen 518057, China.
authors.forename: Jinling
authors.initials: J
authors.lastname: Tang
authors.affiliation: Stroke Center, Neurology &Neurosurgery Division, The Clinical Medicine Research Institute &The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
authors.forename: Keshen
authors.initials: K
authors.lastname: Li
authors.affiliation: School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.|CUHK Shenzhen Research Institute, Shenzhen 518057, China.
authors.forename: Xuefen
authors.initials: X
authors.lastname: Su
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III