title: The Protective Effects of Caffeic Acid Phenethyl Ester on Acetylsalicylic Acid-induced Lung Injury in Rats.
abstract: OBJECTIVE
  We aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on acetylsalicylic acid (ASA)-induced lung damage in rats in the present study.
  
  
  METHODS
  A total of 40 rats were randomly divided into five groups, with eight rats in each group-group 1: control, not receiving any medication; group 2: ASA (50 mg/kg/day); group 3: ASA (50 mg/kg/day) plus CAPE (20 μg/kg/day); group 4: ASA (100 mg/kg/day); and group 5: ASA (100 mg/kg/day) plus CAPE (20 μg/kg/day). ASA and CAPE were given via orogastric gavage for 5 days. The total oxidant status (TOS), total antioxidant capacity (TAC), oxidant stress index (OSI), and paraoxonase-1 (PON-1) activity of the blood samples and lung tissues were determined. Histopathological examinations of the lung tissues were performed by using light microscopic methods.
  
  
  RESULTS
  CAPE treatment significantly increased antioxidant PON-1 level both in the lung tissue and plasma (p < .05). Plasma antioxidant marker (TAC, PON-1) levels significantly increased and oxidant marker (TOS, OSI) levels significantly decreased in CAPE-treated rats (groups 3,5) compared to ASA given no-CAPE groups (group 2,4) (p < .05). Treatment with CAPE improved pulmonary interstitial inflammation and eosinophil accumulation due to ASA histopathologically.
  
  
  CONCLUSIONS
  Eosinophil-rich inflammation and oxidative stress play important roles in ASA-induced lung toxicity, and CAPE may protect against ASA-induced lung toxicity by reduction of oxidative damage and inflammation in rats.
authors.affiliation: a Department of Pulmonary Diseases , Dicle University School of Medicine , Diyarbakir , Turkey.
authors.forename: Mahşuk
authors.initials: M
authors.lastname: Taylan
authors.affiliation: a Department of Pulmonary Diseases , Dicle University School of Medicine , Diyarbakir , Turkey.
authors.forename: Halide
authors.initials: H
authors.lastname: Kaya
authors.affiliation: a Department of Pulmonary Diseases , Dicle University School of Medicine , Diyarbakir , Turkey.
authors.forename: Melike
authors.initials: M
authors.lastname: Demir
authors.affiliation: b Department of Biochemistry , Dicle University School of Medicine , Diyarbakir , Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoğlu
authors.affiliation: a Department of Pulmonary Diseases , Dicle University School of Medicine , Diyarbakir , Turkey.
authors.forename: Hadice Selimoglu
authors.initials: HS
authors.lastname: Sen
authors.affiliation: c Department of Pathology , Dicle University School of Medicine , Diyarbakir , Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Fırat
authors.affiliation: c Department of Pathology , Dicle University School of Medicine , Diyarbakir , Turkey.
authors.forename: Aysenur
authors.initials: A
authors.lastname: Keles
authors.affiliation: a Department of Pulmonary Diseases , Dicle University School of Medicine , Diyarbakir , Turkey.
authors.forename: Sureyya
authors.initials: S
authors.lastname: Yilmaz
authors.affiliation: a Department of Pulmonary Diseases , Dicle University School of Medicine , Diyarbakir , Turkey.
authors.forename: Cengizhan
authors.initials: C
authors.lastname: Sezgi
mesh_terms: D000818:Animals; D001241:Aspirin; D002109:Caffeic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008168:Lung / Q000473:pathology; D055370:Lung Injury / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D018384:Oxidative Stress / Q000187:drug effects; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D017208:Rats, Wistar
chemical_list: D002109:Caffeic Acids; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol; D001241:Aspirin
keywords: acetylsalicylic acid; asa; caffeic acid phenethyl ester; cape; lung injury