title: Effect of Statin Use on Mobility Disability and its Prevention in At-risk Older Adults: The LIFE Study.
abstract: HMG-CoA reductase inhibitors (statins) are among the most commonly prescribed classes of medications. Although their cardiovascular benefits and myalgia risks are well documented, their effects on older adults initiating an exercise training program are less understood.
  
  
  
  1,635 sedentary men and women aged 70-89 years with Short Physical Performance Battery (SPPB) score of 9 or below and were able to walk 400 m were randomized to a structured, moderate-intensity physical activity (PA) program consisting of both center-based (twice/wk) and home-based (3-4 times/wk) aerobic, resistance, and flexibility training or to a health education (HE) program combined with upper extremity stretching.
  
  
  
  Overall, the PA intervention was associated with lower risk of major mobility disability (hazard ratio [HR] = 0.82; 95% confidence interval [CI] = 0.69-0.98). The effect was similar (p value for interaction = .62) in both statin users (PA n = 415, HE n = 412; HR = 0.86, 95% CI = 0.67-1.1) and nonusers (PA n = 402, HE n = 404; HR = 0.78, 95% CI = 0.61-1.01). Attendance was similar for statin users (65%) and nonusers (63%). SPPB at 12 months was slightly greater for PA (8.35±0.10) than for HE (7.94±0.10) in statin users but not in nonusers (PA 8.25±0.10, HE 8.16±0.10), though the interaction effect was not statistically significant. Self-reported PA levels were not different between statin users and nonusers.
  
  
  
  Although statins have been associated with adverse effects on muscle, data from the LIFE Study show that statin users and nonusers both benefit from PA interventions. Older adults who require statin medications to manage chronic medical conditions and are sedentary will be able to benefit from interventions to increase PA.
authors.affiliation: Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina. rmyer@wakehealth.edu.
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Henderson
authors.affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina.
authors.forename: Laura
authors.initials: L
authors.lastname: Lovato
authors.affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Miller
authors.affiliation: Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts.
authors.forename: Roger A
authors.initials: RA
authors.lastname: Fielding
authors.affiliation: Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge.
authors.forename: Tim S
authors.initials: TS
authors.lastname: Church
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pennsylvania.
authors.forename: Anne B
authors.initials: AB
authors.lastname: Newman
authors.affiliation: Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Buford
authors.affiliation: Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Marco
authors.initials: M
authors.lastname: Pahor
authors.affiliation: Department of Aging and Geriatric Research, University of Florida College of Medicine, Gainesville.
authors.forename: Mary M
authors.initials: MM
authors.lastname: McDermott
authors.affiliation: Stanford Prevention Research Center, Stanford School of Medicine, Palo Alto, California.
authors.forename: Randall S
authors.initials: RS
authors.lastname: Stafford
authors.affiliation: College of Pharmacy, Oregon State University and Oregon Health and Science University, Portland.
authors.forename: David S H
authors.initials: DS
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kritchevsky
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015444:Exercise / Q000502:physiology*; D005260:Female; D015577:Geriatric Assessment; D006266:Health Education; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D051346:Mobility Limitation; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data; D057185:Sedentary Behavior; D016037:Single-Blind Method; D014481:United States
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Exercise; Functional performance; Physical activity; Physical function