title: [Peculiarities of the action of hyaluronidase of different origin to the connective tissue].
abstract: The lecture is devoted to consideration of mechanism of therapeutic action of the enzyme hyaluronidase in hyperplastic connective tissue. Drugs based on hyaluronidase increase bioavailability of other drugs used in adjuvant therapy; they significantly increase effectiveness of treatment, and also provide targeted synthesis of hyaluronic acid, ths regulating the regeneration process of connective tissue.
authors.affiliation: Semashko National Research Institute of Public Health, Mosсow, Russia.
authors.forename: R U
authors.initials: RU
authors.lastname: Habriyev
authors.affiliation: Russian Anti-Doping Agency RUSADA, Mosсow, Russia.
authors.forename: N O
authors.initials: NO
authors.lastname: Kamayev
authors.affiliation: "Biocenter" Ltd, Ivanovo, Ivanovo region, Russia.
authors.forename: T I
authors.initials: TI
authors.lastname: Danilova
authors.affiliation: Russian pharmaceutical company "Pharma" Ltd, Mosсow, Russia.
authors.forename: E G
authors.initials: EG
authors.lastname: Kakhoyan
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000493:pharmacokinetics / Q000627:therapeutic use; D009928:Organ Specificity / Q000187:drug effects
chemical_list: D006821:Hyaluronoglucosaminidase
keywords: classification of hyaluronidase; connective tissue; extracellular matrix; hyaluronate-lyase from non-pathogenic strain of bacteria of the genus Streptomyces; hyaluronic acid (hyaluronan); hyaluronidase from the testes of cattle