title: Steroidal Glucosides from the Rhizomes of Tacca chantrieri and Their Inhibitory Activities of NO Production in BV2 Cells.
abstract: Two new steroidal glucosides, chantriolides D and E (1 and 2), along with four known compounds, chantriolide A (3), chantriolide B (4), chantriolide C (5), and (25S)-spirost-5-en-3-ol 3-O-α-L-rhamnopyranosyl-(1-->2)-O-[α-L-rhamnopyranosyl-(1-->3)]-β-D-glucopyranoside (6) were isolated from the rhizomes of Tacca chantrieri. Their structures were determined by 1D and 2D NMR spectroscopic and HR-ESI-MS data, as well as by comparison with reported data. Compounds 1 and 2 were found to show strong inhibitory NO effect in BV2 cells, with IC₅₀ values of 12.45 and 59.03 µM, respectively.
authors.forename: Pham Hai
authors.initials: PH
authors.lastname: Yen
authors.forename: Vu Thi Quynh
authors.initials: VT
authors.lastname: Chi
authors.forename: Dong-Cheol
authors.initials: DC
authors.lastname: Kim
authors.forename: Wonmin
authors.initials: W
authors.lastname: Ko
authors.forename: Hyuncheol
authors.initials: H
authors.lastname: Oh
authors.forename: Youn-Chul
authors.initials: YC
authors.lastname: Kim
authors.forename: Duong Thi
authors.initials: DT
authors.lastname: Dung
authors.forename: Nguyen Thi Viet
authors.initials: NT
authors.lastname: Thanh
authors.forename: Tran Hong
authors.initials: TH
authors.lastname: Quang
authors.forename: Nguyen Thi Thanh
authors.initials: NT
authors.lastname: Ngan
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiema
authors.forename: Hoang Le Tuan
authors.initials: Hle T
authors.lastname: Anh
authors.forename: Chan Van
authors.initials: CV
authors.lastname: Minh
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
mesh_terms: D002460:Cell Line; D027743:Dioscoreaceae / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D017628:Microglia / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D027343:Rhizome / Q000737:chemistry*
chemical_list: D005960:Glucosides; D009569:Nitric Oxide