title: Flavored Intravenous Ondansetron Administered Orally for the Treatment of Persistent Vomiting in Children.
abstract: To study the serum level of ondansetron after oral administration of intravenous ondansetron, and test the palatability of the drug after being flavored.
  
  
  
  This is a single-center prospective study enrolling children aged 3-8 years with gastroenteritis treated for persistent vomiting; patients received single dose of flavored intravenous ondansetron orally. The primary outcome was ondansetron serum level at 4 hours. Secondary outcome was palatability of the drug.
  
  
  
  Forty previously healthy patients presenting with acute gastroenteritis were enrolled. The mean age was 4.86±1.37 years. Serum level at 4 h had a median of 26.23 ng/ml, range (8.3-52 ng/ml). Palatability of the drug had a mean of 3.23 (of 5) ± 0.80, based on score from visual analog scale.
  
  
  
  Flavored intravenous ondansetron administered orally is a safe and an effective option and can be considered in the absence of the oral forms of the drug.
authors.affiliation: Division of Pediatric Emergency Medicine, Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar.
authors.forename: Khalid
authors.initials: K
authors.lastname: Ibrahim
authors.affiliation: Division of Pediatric Emergency Medicine, Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar Division of Pediatric Emergency Medicine, Department of Pediatrics, Sidra Medical and Research Centre, Doha, Qatar Weill Cornell Medical College, Doha, Qatar dkmaa@hotmail.com.
authors.forename: Khalid
authors.initials: K
authors.lastname: Al Ansari
mesh_terms: D061605:Administration, Intravenous; D000284:Administration, Oral; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005759:Gastroenteritis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D017294:Ondansetron / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use*; D010147:Pain Measurement; D010865:Pilot Projects; D011446:Prospective Studies; D016896:Treatment Outcome; D014839:Vomiting / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000932:Antiemetics; D017294:Ondansetron
keywords: gastroenteritis; ondansetron; ondansetron serum level.; palatability; vomiting