title: Synthesis and biological evaluation of novel 2,3-dihydrochromeno[3,4-d]imidazol-4(1H)-one derivatives as potent anticancer cell proliferation and migration agents.
abstract: In this study, a series of novel molecules containing chromeno [3,4-d] imidazol-4(1H)-one was synthesized and their biological activities were evaluated. Among them, compound 35 showed a dramatic anticancer activity against HCT116 and MCF-7, and the flow cytometry assays demonstrated that it could arrest G0/G1 cell-cycle and induce apoptosis of SW620 cells in a dose-dependent manner. Besides, it also blocked MCF-7 cancer cell migration. Moreover, it inhibited tumor growth in HCT116 subcutaneously implanted xenografted mice. Taken together, compound 35 may be a promising candidate for anti-cancer agent as well as metastatic one.
authors.affiliation: National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041 Sichuan, PR China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Han
authors.affiliation: National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041 Sichuan, PR China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Luo
authors.affiliation: National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041 Sichuan, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wu
authors.affiliation: National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041 Sichuan, PR China.
authors.forename: XueYan
authors.initials: X
authors.lastname: Hou
authors.affiliation: National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041 Sichuan, PR China.
authors.forename: Guoyi
authors.initials: G
authors.lastname: Yan
authors.affiliation: Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guiyang Medical University, 9 Beijing Road, Guiyang, Guizhou 550004, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhou
authors.affiliation: National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041 Sichuan, PR China.
authors.forename: Mengqi
authors.initials: M
authors.lastname: Zhang
authors.affiliation: National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041 Sichuan, PR China.
authors.forename: Chunlan
authors.initials: C
authors.lastname: Pu
authors.affiliation: National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041 Sichuan, PR China. Electronic address: lirui@scu.edu.cn.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D002867:Chromones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: C000613140:2,3-dihydrochromeno(3,4-d)imidazol-4(1H)-one; D000970:Antineoplastic Agents; D002867:Chromones; D007093:Imidazoles
keywords: Anti-cancer agents; Anti-metastasis; Chromeno [3,4-d] imidazol-4(1H)-one