title: Persistent severe polyuria after renal transplant.
abstract: Polydipsia and polyuria are common symptoms in patients with diabetes insipidus (DI), which can be due to inadequate vasopressin production (cranial DI) or vasopressin insensitivity (nephrogenic DI). Clinical diagnosis of the subtypes of DI can be tricky. We present a 44-year-old man with a strong family history of DI who had been diagnosed with autosomal dominant nephrogenic DI from infancy. At the age of 40, he had progressed to end-stage renal failure. When he experienced unresolving severe polyuria after renal transplant, further investigations revealed that he was misdiagnosed and that he had a novel mutation causing autosomal dominant cranial DI.
authors.affiliation: Medical School , UCL , London , UK.
authors.forename: Timothy
authors.initials: T
authors.lastname: Wong
authors.affiliation: UCL Centre for Nephrology , Royal Free Hospital , London , UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Laing
authors.affiliation: Department of Genetics, Evolution and Environment , UCL , London , UK.
authors.forename: Rosemary
authors.initials: R
authors.lastname: Ekong
authors.affiliation: Department of Genetics, Evolution and Environment , UCL , London , UK.
authors.forename: Sue
authors.initials: S
authors.lastname: Povey
authors.affiliation: Division of Medicine , University College London , London , UK.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Unwin
keywords: chronic renal failure; congenital cranial diabetes insipidus; genetic testing; hereditary polyuric states; kidney transplantation