title: Evaluation of hepatoprotective activity of the commerson's anchovy (Stolephorus commersonnii).
abstract: OBJECTIVE
  In the present study, we have chosen a fish Stolephorus commersonnii which is abundant in whitebait catches along Kerala coast. This fish is reported to contain higher content of essential amino acids, monounsaturated fatty acids, polyunsaturated fatty acids and minerals. The medicinal values of this species have not been reported and remain unexplored. Hence, there is a necessity to explore their uses and to conduct the pharmacological studies to ascertain their therapeutic properties. Based on literature search, no study has been carried out to scientifically validate the fish S. commersonnii possesses hepatoprotective property. Hence, this study was carried out to investigate the hepatoprotective effect of the S. commersonnii.
  
  
  METHODS
  The fish was purchased from the fish market, Ernakulam, Kerala, India. The fish were kept on ice until processed in the lab. Fish is washed and cleaned properly. The tissue is homogenized and extracted with chloroform: methanol solvent system. The extract is transferred to a dark glass container and stored in a freezer. The preliminary analysis of fish extract was carried out by simple qualitative methods. The hepatoprotective activity of Stolephorus commersonnii (SC) extract at 300 mg/kg is carried out in isoniazid induced hepatotoxic model. The albino rats of either sex were used for these studies.
  
  
  RESULTS
  The results of hepatoprotective study revealed that the SC extract showed a liver protective action against isoniazid induced toxicity.
  
  
  CONCLUSIONS
  The present study suggests that the extract of S. commersonnii fish has therapeutic potential in the management of drug induced liver toxicity.
authors.affiliation: Department of Pharmaceutical Sciences, Mahatma Gandhi University Regional Institute of Medical Sciences and Research, Kottayam, Kerala, India.
authors.forename: Jeffy A
authors.initials: JA
authors.lastname: Varkey
authors.affiliation: Department of Pharmaceutical Sciences, Mahatma Gandhi University Regional Institute of Medical Sciences and Research, Kottayam, Kerala, India.
authors.forename: A Abdul
authors.initials: AA
authors.lastname: Vahab
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000009:adverse effects*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005399:Fishes; D007538:Isoniazid / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid
keywords: Hepatoprotective; SC; Stolephorus commersonnii; isoniazid induced toxicity