title: Synthesis, NMR and crystal characterization of dimeric terephthalates derived from epimeric 4,5-seco-cholest-3-yn-5-ols.
abstract: Two dimeric steroidal terephthalates derived from epimeric 4,5-seco-cholest-3-yn-5-ols were prepared starting from cholesterol in a five-step synthetic sequence. X-ray crystallography shows that the obtained compounds display novel supramolecular networks in the solid state in which the facial hydrophobicity of the steroidal skeletons plays an important role. Unambiguous NMR characterization of the obtained dimers is also provided.
authors.affiliation: Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510 México, D.F., Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Alarcón-Manjarrez
authors.affiliation: Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, 04510 México, D.F., Mexico.
authors.forename: Rafael
authors.initials: R
authors.lastname: Arcos-Ramos
authors.affiliation: Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510 México, D.F., Mexico.
authors.forename: Marcos Flores
authors.initials: MF
authors.lastname: Álamo
authors.affiliation: Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510 México, D.F., Mexico. Electronic address: martin.iglesias@unam.mx.
authors.forename: Martín A
authors.initials: MA
authors.lastname: Iglesias-Arteaga
mesh_terms: D060326:Chemistry Techniques, Synthetic; D002784:Cholesterol / Q000737:chemistry*; D018360:Crystallography, X-Ray; D019281:Dimerization; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010795:Phthalic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D010795:Phthalic Acids; C011363:terephthalic acid; D002784:Cholesterol
keywords: Dimeric steroidal terephthalates; Epimeric 4,5-seco-cholest-3-yn-5-ols; NMR; X-ray diffraction