title: Common genetic risk factors of venous thromboembolism in Western and Asian populations.
abstract: Venous thromboembolism (VTE) is a multifactorial disorder involving both acquired and genetic risk factors. The common genetic factors in Western populations have been studied and reported for several decades, while studies on Asian populations are relatively scarce. Evidence suggests that the prevalence and genetic risk factors of VTE vary significantly among ethnic populations. In this review, we summarize the common genetic risk factors of VTE in both Western and Asian populations. In addition to the development of DNA sequencing technology, genome-wide association studies have many advantages and are becoming more important in identifying new genetic risk factors and susceptible loci. They can therefore help in the prediction and prevention of VTE.
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors.forename: S S
authors.initials: SS
authors.lastname: Huang
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases.
authors.forename: Z C
authors.initials: ZC
authors.lastname: Jing
authors.affiliation: State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases.
authors.forename: X J
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Mao
mesh_terms: D044466:Asian People / Q000235:genetics; D005006:Ethnicity / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D015995:Prevalence; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D054556:Venous Thromboembolism / Q000453:epidemiology / Q000235:genetics*; D044465:White People / Q000235:genetics