title: Comparison of Phacotrabeculectomy and Phacotrabeculectomy with Subconjunctival 5-Fluorouracil.
abstract: BACKGROUND
  Glaucoma is the second leading cause of blindness worldwide. Phacotrabeculectomy is a technique in which glaucoma and cataract surgery performed.
  
  
  METHODS
  Prospective study was carried out in the department of glaucoma at Lumbini Eye Institute, Bhairahawa.100 patients who underwent phacotrabeculectomy within a period of two years. Patients were divided into two groups those who received 5FU (n=47) and no antifibrotic agent (n= 53) RESULTS: The age range was from 38 to 80 years; mean age of 62.97±9.14 SD. 55% were male and 45% were female.The postoperative IOP reduction in last follow- up group A was mean=13.08±1.57SD and mean=13.23±1.73SD in group B. This was statically significant with P <0.001. Bleb survival was almost similar in two groups 3.17(78.31%) in group A and 3.20 (78.93%) in group B. 85% visual acuity was improved in both groups.
  
  
  CONCLUSIONS
  Phacotrabeculectomy and phacotrabeculectomy with inj. 5FU, both were equally effective surgical techniques in terms of visual acuity, IOP control and bleb survival.There was no significant statistical difference vis-à-vis the success of Phacotrabeculectomy using of either these two techniques.
authors.affiliation: Department of Glaucoma Lumbini Eye Institute, Bhairahawa, Nepal.
authors.forename: N K
authors.initials: NK
authors.lastname: Gurung
authors.affiliation: Department of Glaucoma Lumbini Eye Institute, Bhairahawa, Nepal.
authors.forename: P
authors.initials: P
authors.lastname: Gautam
authors.affiliation: Department of Glaucoma Lumbini Eye Institute, Bhairahawa, Nepal.
authors.forename: S
authors.initials: S
authors.lastname: Gurung
authors.affiliation: Department of Glaucoma Lumbini Eye Institute, Bhairahawa, Nepal.
authors.forename: B
authors.initials: B
authors.lastname: Bhattarai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000963:Antimetabolites / Q000008:administration & dosage*; D002386:Cataract / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D002387:Cataract Extraction / Q000379:methods; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D056965:Injections, Intraocular; D007429:Intraocular Pressure; D019654:Lens Implantation, Intraocular / Q000379:methods; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification / Q000379:methods; D011446:Prospective Studies; D014130:Trabeculectomy / Q000379:methods; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D000963:Antimetabolites; D005472:Fluorouracil
keywords: glaucoma; 5FU; intraocular pressure; phacotrabeculectomy.