title: A Comparison of Intraoperative Dexamethasone Intravitreal Implant and Triamcinolone Acetonide Used During Vitrectomy and Epiretinal Membrane Peeling: A Case Control Study.
abstract: OBJECTIVE
  Intravitreal corticosteroids may accelerate the normalization of macular morphology after vitrectomy and epiretinal membrane (ERM) peeling. The authors compared the visual and anatomic outcomes of eyes undergoing this procedure with the intraoperative use of the dexamethasone intravitreal implant (DEX) (Ozurdex; Allergan, Irvine, CA) versus triamcinolone acetonide (IVTA) (Triesence; Alcon, Fort Worth, TX).
  
  
  METHODS
  Interventional, retrospective, consecutive, case-control study.
  
  
  RESULTS
  Fifty-five participants were included (DEX = 19; IVTA = 36). Best-corrected visual acuity (BCVA) improved at 1, 2, 3, and 6 months in both the DEX (P = .40, .45, .02, .08, respectively) and IVTA (P < .01, = .10, < .01, < .01) arms. Similarly, central macular thickness (CMT) improved at 1, 2, 3, and 6 months in both the DEX (P < .01, = .03, < .01, < .01) and IVTA (P < .01, < .01, < .01, < .01) arms. There were no statistical differences between DEX and IVTA regarding BCVA and CMT.
  
  
  CONCLUSIONS
  Both intraoperative DEX and IVTA, used at the completion of vitrectomy and at membrane peeling for epiretinal membrane, were effective in improving visual and anatomic outcomes, though there was a trend toward greater significance with IVTA.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yonekawa
authors.forename: Danny A
authors.initials: DA
authors.lastname: Mammo
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Thomas
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Wolfe
authors.forename: Tarek S
authors.initials: TS
authors.lastname: Hassan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D019773:Epiretinal Membrane / Q000601:surgery*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007430:Intraoperative Care; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone; D014222:Triamcinolone Acetonide