title: Tranexamic acid-associated seizures: A meta-analysis.
abstract: OBJECTIVE
  To investigate the incidence rate of tranexamic acid (TXA)-associated seizures.
  
  
  METHODS
  Two electronic databases (Medline and Embase) were searched. We looked for additional studies in the references of all identified publications. The cutoff day was 2015 Dec 06. Two authors independently reviewed the titles and abstracts of the publications identified firstly. Odds ratio (OR) and 95% confidence interval (CI) were used to compare discontinuous variables.
  
  
  RESULTS
  Ten studies enrolling 26,079 patients with TXA exposure and 7395 patients with non-TXA exposure were included. The cumulative incidence rate of TXA-associated seizures is 2.7%. The odds ratio of seizure is 5.39 (95%CI: 3.29-8.85; I(2)=0%; P<0.001) in patients with TXA exposure vs patients with non-TXA exposure. The incidence rate of TXA-associated seizures increased when the dose levels increased.
  
  
  CONCLUSIONS
  The risk of seizure increased in patients with TXA exposure and the incidence rate of TXA-associated seizures increased when the dose levels increased.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, China. Electronic address: xiaoyizou@163.com.
authors.forename: Zou
authors.initials: Z
authors.lastname: Xiaoyi
mesh_terms: D000933:Antifibrinolytic Agents / Q000009:adverse effects*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016017:Odds Ratio; D012640:Seizures / Q000139:chemically induced*; D014148:Tranexamic Acid / Q000009:adverse effects*
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid
keywords: Meta-analysis; Seizure incidence; Tranexamic acid