title: In vitro controlled release of clove essential oil in self-assembly of amphiphilic polyethylene glycol-block-polycaprolactone.
abstract: In this study, a micellar delivery system with an amphiphilic diblock copolymer of poly (ethylene glycol) and poly (ɛ-caprolactone) was synthesised and used to incorporate hydrophobic clove essential oil (CEO). To determine an optimal delivery system, the effects of the copolymer's hydrophobic block length and the CEO-loading content on the encapsulation of CEO were investigated. Percentages of entrapment efficiency (%EE), CEO loading (%CEO), and in vitro release profiles were determined. The size, size distribution, zeta potential, and morphology of the obtained micelles were determined by DLS, FE-SEM, and TEM. The %EE, %CEO, and in vitro release profiles of CEO incorporated in micelles were analysed by HPLC. The study revealed a sustained release profile of CEO from CEO-loaded micelles. The results indicate the successful formulation of CEO-loaded PEG-b-PCL micelle nanoparticles. It is suggested that this micelle system has considerably potential applications in the sustained release of CEO in intravascular drug delivery.
authors.affiliation: a Department of Textile Science and Technology, Faculty of Science and Technology , Thammasat University , Pathumthani , Thailand ;
authors.forename: O
authors.initials: O
authors.lastname: Thonggoom
authors.affiliation: a Department of Textile Science and Technology, Faculty of Science and Technology , Thammasat University , Pathumthani , Thailand ;
authors.forename: N
authors.initials: N
authors.lastname: Punrattanasin
authors.affiliation: b Materials Science and Engineering Program, Faculty of Science , Mahidol University , Bangkok , Thailand ;
authors.forename: N
authors.initials: N
authors.lastname: Srisawang
authors.affiliation: b Materials Science and Engineering Program, Faculty of Science , Mahidol University , Bangkok , Thailand ;
authors.forename: N
authors.initials: N
authors.lastname: Promawan
authors.affiliation: c Department of Chemistry, Faculty of Science , Mahidol University , Bangkok , Thailand ;|d Center for Surface Science and Engineering, Faculty of Science , Mahidol University , Nakhon Pathom , Thailand.
authors.forename: R
authors.initials: R
authors.lastname: Thonggoom
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D045783:Clove Oil / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D065546:Drug Liberation; D007783:Lactones / Q000737:chemistry*; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D009822:Oils, Volatile / Q000008:administration & dosage / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry; D027842:Syzygium / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D045783:Clove Oil; D003692:Delayed-Action Preparations; D007783:Lactones; D008823:Micelles; D009822:Oils, Volatile; D013501:Surface-Active Agents; C521904:poly(ethylene glycol)-block-poly(epsilon-caprolactone); D011092:Polyethylene Glycols
keywords: PCL; PEG; amphiphilic micelle; biodegradable polymer; clove essential oil; controlled release