title: CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study.
abstract: Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002), while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus (HPV) type, patients carrying the CCR2-64Ipolymorphism were protected against infection by HPV type 16 (OR = 0.35, p = 0.0184). In summary, our study showed a protective effect ofCCR2-64I rs1799864 polymorphism against the development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection.
authors.affiliation: Universidade Federal Rural de Pernambuco, Recife, PE, Brasil.
authors.forename: Erinaldo Ubirajara Damasceno dos
authors.initials: EU
authors.lastname: Santos
authors.affiliation: Universidade de Pernambuco, Recife, PE, Brasil.
authors.forename: Géssica Dayane Cordeiro de
authors.initials: GD
authors.lastname: Lima
authors.affiliation: Laboratório Central de Saúde Pública de Pernambuco, Recife, PE, Brasil.
authors.forename: Micheline de Lucena
authors.initials: Mde L
authors.lastname: Oliveira
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brasil.
authors.forename: Sandra de Andrade
authors.initials: Sde A
authors.lastname: Heráclio
authors.affiliation: Instituto Federal de Pernambuco, Garanhuns, PE, Brasil.
authors.forename: Hildson Dornelas Angelo da
authors.initials: HD
authors.lastname: Silva
authors.affiliation: Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
authors.affiliation: Universidade Federal Rural de Pernambuco, Recife, PE, Brasil.
authors.forename: Maria de Mascena Diniz
authors.initials: Mde M
authors.lastname: Maia
authors.affiliation: Universidade Federal Rural de Pernambuco, Recife, PE, Brasil.
authors.forename: Paulo Roberto Eleutério de
authors.initials: PR
authors.lastname: Souza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000453:epidemiology*; D011110:Polymorphism, Genetic; D015995:Prevalence; D054390:Receptors, CCR2 / Q000235:genetics*; D019713:Receptors, CCR5 / Q000235:genetics*; D065310:Squamous Intraepithelial Lesions of the Cervix / Q000235:genetics / Q000821:virology; D002577:Uterine Cervical Diseases / Q000235:genetics* / Q000821:virology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000235:genetics / Q000821:virology
chemical_list: C515334:CCR2 protein, human; C584933:CCR5 protein, human; D054390:Receptors, CCR2; D019713:Receptors, CCR5