title: The multifaceted role of astrocytes in regulating myelination.
abstract: Astrocytes are the major glial cell of the central nervous system (CNS), providing both metabolic and physical support to other neural cells. After injury, astrocytes become reactive and express a continuum of phenotypes which may be supportive or inhibitory to CNS repair. This review will focus on the ability of astrocytes to influence myelination in the context of specific secreted factors, cytokines and other neural cell targets within the CNS. In particular, we focus on how astrocytes provide energy and cholesterol to neurons, influence synaptogenesis, affect oligodendrocyte biology and instigate cross-talk between the many cellular components of the CNS.
authors.affiliation: Institute of Infection, Inflammation and Immunity, Sir Graeme Davies Building, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom.
authors.forename: Hülya
authors.initials: H
authors.lastname: Kıray
authors.affiliation: Institute of Infection, Inflammation and Immunity, Sir Graeme Davies Building, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Lindsay
authors.affiliation: Institute of Infection, Inflammation and Immunity, Sir Graeme Davies Building, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom.
authors.forename: Sara
authors.initials: S
authors.lastname: Hosseinzadeh
authors.affiliation: Institute of Infection, Inflammation and Immunity, Sir Graeme Davies Building, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom.. Electronic address: Susan.Barnett@Glasgow.ac.uk.
authors.forename: Susan C
authors.initials: SC
authors.lastname: Barnett
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000737:chemistry / Q000502:physiology*; D002454:Cell Differentiation; D002490:Central Nervous System; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D009186:Myelin Sheath / Q000502:physiology*; D009474:Neurons / Q000502:physiology
chemical_list: D016207:Cytokines
keywords: Astrocytes; Microglia; Myelination; Neurons; Oligodendrocytes; Phenotypes