title: Heparan Sulfate in the Developing, Healthy, and Injured Lung.
abstract: Remarkable progress has been achieved in understanding the regulation of gene expression and protein translation, and how aberrancies in these template-driven processes contribute to disease pathogenesis. However, much of cellular physiology is controlled by non-DNA, nonprotein mediators, such as glycans. The focus of this Translational Review is to highlight the importance of a specific glycan polymer-the glycosaminoglycan heparan sulfate (HS)-on lung health and disease. We demonstrate how HS contributes to lung physiology and pathophysiology via its actions as both a structural constituent of the lung parenchyma as well as a regulator of cellular signaling. By highlighting current uncertainties in HS biology, we identify opportunities for future high-impact pulmonary and critical care translational investigations.
authors.affiliation: 1 Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado; and.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Haeger
authors.affiliation: 1 Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado; and.
authors.forename: Yimu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: 1 Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado; and.|2 Department of Medicine, Denver Health Medical Center, Denver, Colorado.
authors.forename: Eric P
authors.initials: EP
authors.lastname: Schmidt
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D006497:Heparan Sulfate / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000196:embryology* / Q000378:metabolism* / Q000503:physiopathology; D055370:Lung Injury / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction
chemical_list: D006497:Heparan Sulfate
keywords: glycocalyx; glycosaminoglycan; heparan sulfate; proteoglycan