title: Pro-Cognitive Properties of the Immunomodulatory Polypeptide Complex, Yolkin, from Chicken Egg Yolk and Colostrum-Derived Substances: Analyses Based on Animal Model of Age-Related Cognitive Deficits.
abstract: The study aimed to assess the effect of the polypeptide Y complex (Yolkin), isolated from chicken egg yolk, on behavioural and cognitive functions. It also aimed to compare this activity with colostrum-derived substances (Colostrinin, Coloco), which have a confirmed impact on learning and memory. In the study, the effect of Yolkin, administered to rats of different ages, who performed various tasks involving spatial and episodic memory, motor functions and exploratory behavior, was assessed. The experiment was carried out in rats which were 6 and 12 months old. Two different doses of the studied specimens based on previous comparative studies and two different routes of administration (oral and retroperitoneal) were used. A series of behavioural tests were carried out, including an open field test, a novel object recognition test and a Morris water maze. They were used to evaluate the impact of the studied specimen on improving locomotor function and exploratory behaviour, preventing their decline and assess the functioning of episodic and spatial memory in aging rats. The administration of Yolkin gave distinct effects compared to colostrum-derived substances, although confirmed its suggested pro-cognitive action. Therefore, it may be used to enhance cognitive functions and inhibit the progression of dementia in the course of neurodegenerative disorders.
authors.affiliation: Division of Consultation Psychiatry and Neuroscience, Department of Psychiatry, Wroclaw Medical University, 10 Pasteura Street, 50-367, Wroclaw, Poland. m.lemieszewska@gmail.com.
authors.forename: Marta
authors.initials: M
authors.lastname: Lemieszewska
authors.affiliation: Division of Consultation Psychiatry and Neuroscience, Department of Psychiatry, Wroclaw Medical University, 10 Pasteura Street, 50-367, Wroclaw, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Jakubik-Witkowska
authors.affiliation: Division of Consultation Psychiatry and Neuroscience, Department of Psychiatry, Wroclaw Medical University, 10 Pasteura Street, 50-367, Wroclaw, Poland.
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Stańczykiewicz
authors.affiliation: Department of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, 37 Chelmonskiego Str, 51-630, Wroclaw, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Zambrowicz
authors.affiliation: Department of Immunochemistry, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla Str, 53-114, Wroclaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Zabłocka
authors.affiliation: Department of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, 37 Chelmonskiego Str, 51-630, Wroclaw, Poland.
authors.forename: Antoni
authors.initials: A
authors.lastname: Polanowski
authors.affiliation: Department of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, 37 Chelmonskiego Str, 51-630, Wroclaw, Poland.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Trziszka
authors.affiliation: Division of Consultation Psychiatry and Neuroscience, Department of Psychiatry, Wroclaw Medical University, 10 Pasteura Street, 50-367, Wroclaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Rymaszewska
mesh_terms: D000375:Aging; D000818:Animals; D030161:Avian Proteins / Q000008:administration & dosage* / Q000276:immunology*; D001835:Body Weight; D002645:Chickens; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000276:immunology*; D003126:Colostrum / Q000276:immunology*; D004527:Egg Proteins / Q000008:administration & dosage* / Q000276:immunology*; D004530:Egg Yolk / Q000276:immunology*; D007107:Immune System; D056747:Immunomodulation / Q000276:immunology; D008297:Male; D018782:Maze Learning; D008568:Memory; D051381:Rats; D017208:Rats, Wistar
chemical_list: D030161:Avian Proteins; D004527:Egg Proteins
keywords: Age-related disorders; Chicken egg yolk; Cognitive deficits; Coloco; Colostrinin; Dementia; Immunomodulatory peptides; Learning; Memory