title: Quantitative optical coherence elastography based on fiber-optic probe for in situ measurement of tissue mechanical properties.
abstract: We developed a miniature quantitative optical coherence elastography (qOCE) instrument with an integrated Fabry-Perot force sensor, for in situ elasticity measurement of biological tissue. The technique has great potential for biomechanics modeling and clinical diagnosis. We designed the fiber-optic qOCE probe that was used to exert a compressive force to deform tissue at the tip of the probe. Using the space-division multiplexed optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to quantify the probe deformation that was proportional to the force applied, and to quantify the tissue deformation corresponding to the external stimulus. Simultaneous measurement of force and displacement allowed us to extract Young's modulus of biological tissue. We experimentally calibrated our qOCE instrument, and validated its effectiveness on tissue mimicking phantoms and biological tissues.
authors.affiliation: Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
authors.forename: Yahui
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Electrical and Electronic Engineering, Hong Kong University, Hong Kong, China.
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
authors.forename: Namas
authors.initials: N
authors.lastname: Chandra
authors.affiliation: Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
authors.forename: James
authors.initials: J
authors.lastname: Haorah
authors.affiliation: Department of Radiology, New Jersey Medical School, Newark, NJ, 07103, USA.
authors.forename: Basil
authors.initials: B
authors.lastname: Hubbi
authors.affiliation: Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Pfister
authors.affiliation: Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
keywords: (170.4500) Optical coherence tomography; (280.3340) Laser Doppler velocimetry; (280.4788) Optical sensing and sensors