title: R1 changes in the human placenta at 3 T in response to a maternal oxygen challenge protocol.
abstract: Oxygen-enhanced MRI non-invasively monitors placental oxygenation in-vivo. This technique has been demonstrated at 1.5 Tesla (T) in healthy pregnancies. The aim of this study was to investigate whether findings are comparable at 3T. Nine pregnant volunteers underwent MRI at 3T. Scans obtained R1 (1/T1) measures from T1 maps under air, followed by a dynamic series breathing 100% oxygen. A statistically significant negative correlation was found between dR1 and gestation (P = 0.0008, r = -0.90, Pearson correlation test). The effect of the field strength was not significant within regression analysis. Placental Oxygen-Enhanced MRI at 3T gives comparable results to those previously obtained at 1.5T.
authors.affiliation: Maternal & Fetal Health Research Centre, University of Manchester, UK. Electronic address: emma.ingram@manchester.ac.uk.
authors.forename: Emma
authors.initials: E
authors.lastname: Ingram
authors.affiliation: Maternal & Fetal Health Research Centre, University of Manchester, UK.
authors.forename: Lauren
authors.initials: L
authors.lastname: Hawkins
authors.affiliation: Centre for Imaging Science, Institute of Population Health, University of Manchester, UK.
authors.forename: David M
authors.initials: DM
authors.lastname: Morris
authors.affiliation: Maternal & Fetal Health Research Centre, University of Manchester, UK.
authors.forename: Jenny
authors.initials: J
authors.lastname: Myers
authors.affiliation: Maternal & Fetal Health Research Centre, University of Manchester, UK.
authors.forename: Colin P
authors.initials: CP
authors.lastname: Sibley
authors.affiliation: Maternal & Fetal Health Research Centre, University of Manchester, UK.
authors.forename: Edward D
authors.initials: ED
authors.lastname: Johnstone
authors.affiliation: Centre for Imaging Science, Institute of Population Health, University of Manchester, UK.
authors.forename: Josephine H
authors.initials: JH
authors.lastname: Naish
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D010920:Placenta / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: MRI; Oxygen-enhanced; Placenta