title: Emerging nexus between RAB GTPases, autophagy and neurodegeneration.
abstract: The RAB class of small GTPases includes the major regulators of intracellular communication, which are involved in vesicle generation through fusion and fission, and vesicular trafficking. RAB proteins also play an imperative role in neuronal maintenance and survival. Recent studies in the field of neurodegeneration have also highlighted the process of autophagy as being essential for neuronal maintenance. Here we review the emerging roles of RAB proteins in regulating macroautophagy and its impact in the context of neurodegenerative diseases.
authors.affiliation: a Department of Biological Sciences & Bioengineering , Indian Institute of Technology , Kanpur , India.
authors.forename: Navodita
authors.initials: N
authors.lastname: Jain
authors.affiliation: a Department of Biological Sciences & Bioengineering , Indian Institute of Technology , Kanpur , India.
authors.forename: Subramaniam
authors.initials: S
authors.lastname: Ganesh
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D001692:Biological Transport / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D020691:rab GTP-Binding Proteins
keywords: GTPase; RAB proteins; autophagy; endocytosis; intracellular trafficking; neurodegeneration; neuronal maintenance; stress response