title: Gender differences for uric acid as predictor of hard events in patients referred for coronary angiography.
abstract: OBJECTIVE
  To assess gender differences in uric acid (UA) as predictor for hard events (HE, mortality and nonfatal myocardial infarction) in a large cohort of patients referred for coronary angiography. Design & patients: 3020 inpatients (2177 males, age: 68 ± 9 years, mean ± SD) were retrospectively studied, collecting data from the Institute electronic databank which included demographic, clinical, instrumental and follow-up data.
  
  
  RESULTS
  Although the Kaplan-Meier survival estimates showed a significantly worst outcome in female patients, high UA did not remained a significant predictor for HE after adjustment. Moreover, UA correlated with antioxidant capacity in both sexes.
  
  
  CONCLUSIONS
  Hyperuricemia was not an independent risk for HE, and being correlated with antioxidant capacity, its elevation appears more likely compensatory than causative for HE.
authors.affiliation: Fondazione G Monasterio CNR-Regione Toscana & Istituto di Fisiologia Clinica-CNR Via Moruzzi 1, I-56124 Pisa, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Vassalle
authors.affiliation: Fondazione G Monasterio CNR-Regione Toscana & Istituto di Fisiologia Clinica-CNR Via Moruzzi 1, I-56124 Pisa, Italy.
authors.forename: Kyriazoula
authors.initials: K
authors.lastname: Chatzianagnostou
authors.affiliation: Fondazione G Monasterio CNR-Regione Toscana & Istituto di Fisiologia Clinica-CNR Via Moruzzi 1, I-56124 Pisa, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vannucci
authors.affiliation: Fondazione G Monasterio CNR-Regione Toscana & Istituto di Fisiologia Clinica-CNR Via Moruzzi 1, I-56124 Pisa, Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Guiducci
authors.affiliation: Fondazione G Monasterio CNR-Regione Toscana & Istituto di Fisiologia Clinica-CNR Via Moruzzi 1, I-56124 Pisa, Italy.
authors.forename: Debora
authors.initials: D
authors.lastname: Battaglia
authors.affiliation: Fondazione G Monasterio CNR-Regione Toscana & Istituto di Fisiologia Clinica-CNR Via Moruzzi 1, I-56124 Pisa, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Maffei
authors.affiliation: Fondazione G Monasterio CNR-Regione Toscana & Istituto di Fisiologia Clinica-CNR Via Moruzzi 1, I-56124 Pisa, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Arvia
authors.affiliation: Fondazione G Monasterio CNR-Regione Toscana & Istituto di Fisiologia Clinica-CNR Via Moruzzi 1, I-56124 Pisa, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Landi
authors.affiliation: Fondazione G Monasterio CNR-Regione Toscana & Istituto di Fisiologia Clinica-CNR Via Moruzzi 1, I-56124 Pisa, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Carpeggiani
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging* / Q000401:mortality; D009765:Obesity / Q000150:complications; D012189:Retrospective Studies; D012737:Sex Factors; D014527:Uric Acid / Q000032:analysis*
chemical_list: D014527:Uric Acid
keywords: all-cause mortality; cardiovascular disease; gender; nonfatal myocardial infarction; prognosis; sex-related differences; uric acid