title: Status of vaccine research and development of vaccines for Nipah virus.
abstract: Nipah virus (NiV) is a highly pathogenic, recently emerged paramyxovirus that has been responsible for sporadic outbreaks of respiratory and encephalitic disease in Southeast Asia. High case fatality rates have also been associated with recent outbreaks in Malaysia and Bangladesh. Although over two billion people currently live in regions in which NiV is endemic or in which the Pteropus fruit bat reservoir is commonly found, there is no approved vaccine to protect against NiV disease. This report examines the feasibility and current efforts to develop a NiV vaccine including potential hurdles for technical and regulatory assessment of candidate vaccines and the likelihood for financing.
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Satterfield
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.
authors.forename: Brian E
authors.initials: BE
authors.lastname: Dawes
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States; Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, United States; WHO Collaborating Center, University of Texas Medical Branch, Galveston, TX, United States. Electronic address: gnmillig@utmb.edu.
authors.forename: Gregg N
authors.initials: GN
authors.lastname: Milligan
mesh_terms: D000818:Animals; D001210:Asia, Southeastern; D035843:Biomedical Research / Q000639:trends; D002685:Chiroptera / Q000821:virology; D004353:Drug Evaluation, Preclinical; D045464:Henipavirus Infections / Q000517:prevention & control*; D006801:Humans; D045405:Nipah Virus; D014765:Viral Vaccines / Q000627:therapeutic use*
chemical_list: D014765:Viral Vaccines
keywords: Live attenuated vaccine; Nipah virus; Soluble G protein; Subunit vaccine