title: Markers of Autolysis in Acute ST Elevation Myocardial Infarction.
abstract: BACKGROUND
  The availability of reliable noninvasive markers for infarct-related artery (IRA) patency status are very limited, otherwise could allow early identification of patients with patent IRA, for whom repeat thrombolysis or rescue percutaneous coronary intervention (PCI) are not necessary.
  
  
  METHODS
  We conducted a single centered retrospective study of STEMI patients undergoing primary PCI to determine how various factors such as demographic characteristics, risk markers of coronary heart disease, clinical and blood parameters present differently in patients with higher coronary flow and patent infarct related artery from patients with total occlusion at the time of initial angiography and how they affect in outcome of the disease.
  
  
  RESULTS
  MPV level (11.96 fL vs. 10.92 fL, P < 0.001), Lp (a) level (179.57 nmol/l vs 141.16 nmol/l , p < 0.001), CK-MB (290.2 vs. 190.98, P < 0.001), total cholesterol level (4.11 mmol/L vs. 3.8 mmol/L, p < 0.02) in total occlusion group were higher than in the patent IRA group. Wall motion abnormality was 77.2% for 203 patients with total occlusion group and 54.2% for 83 patients with patent IRA group (P<0.01). Mean hospital stay days were higher in total occlusion group as compared to the patent IRA group P < 0.01.
  
  
  CONCLUSIONS
  MVP, Lp (a), TC, and CK-MB levels and myocardial wall motion at the presentation may play the role of markers for IRA patency status that will help in early identification of patients with IRA, for whom repeat thrombolysis or rescue PCI may not be required.
authors.affiliation: Department of Cardiovascular Unit, First Affiliated Hospital of Xi'an Jiao Tong University School of Medicine, Xi'an, Shaanxi, China.
authors.forename: P
authors.initials: P
authors.lastname: Maharjan
authors.affiliation: Department of Cardiovascular Unit, First Affiliated Hospital of Xi'an Jiao Tong University School of Medicine, Xi'an, Shaanxi, China.
authors.forename: R
authors.initials: R
authors.lastname: Manandhar
authors.affiliation: Department of Cardiovascular Unit, First Affiliated Hospital of Xi'an Jiao Tong University School of Medicine, Xi'an, Shaanxi, China.
authors.forename: W
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Cardiovascular Unit, First Affiliated Hospital of Xi'an Jiao Tong University School of Medicine, Xi'an, Shaanxi, China.
authors.forename: S
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Cardiovascular Unit, First Affiliated Hospital of Xi'an Jiao Tong University School of Medicine, Xi'an, Shaanxi, China.
authors.forename: W
authors.initials: W
authors.lastname: Han
authors.affiliation: Department of Cardiovascular Unit, First Affiliated Hospital of Xi'an Jiao Tong University School of Medicine, Xi'an, Shaanxi, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular Unit, First Affiliated Hospital of Xi'an Jiao Tong University School of Medicine, Xi'an, Shaanxi, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Cardiovascular Unit, First Affiliated Hospital of Xi'an Jiao Tong University School of Medicine, Xi'an, Shaanxi, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Rijal
authors.affiliation: Department of Cardiovascular Unit, First Affiliated Hospital of Xi'an Jiao Tong University School of Medicine, Xi'an, Shaanxi, China.
authors.forename: C
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Cardiovascular Unit, First Affiliated Hospital of Xi'an Jiao Tong University School of Medicine, Xi'an, Shaanxi, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Yuan
mesh_terms: D000368:Aged; D001329:Autolysis / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D017023:Coronary Angiography; D003327:Coronary Disease / Q000453:epidemiology; D054059:Coronary Occlusion / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism* / Q000601:surgery; D052279:Creatine Kinase, MB Form / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000453:epidemiology; D050171:Dyslipidemias / Q000453:epidemiology; D004452:Echocardiography; D005260:Female; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D007902:Length of Stay; D017270:Lipoprotein(a) / Q000378:metabolism*; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism* / Q000601:surgery; D012907:Smoking / Q000453:epidemiology; D014280:Triglycerides / Q000378:metabolism
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D014280:Triglycerides; D006710:Homocysteine; D002097:C-Reactive Protein; D002784:Cholesterol; D052279:Creatine Kinase, MB Form
keywords: acute coronary syndrome; infarct related artery; myocardial infarction.