title: Orbital atherectomy for severely calcified lesions: More dissections in women but similar 30-day outcomes to men.
abstract: Calcified lesions are associated with lower rates of successful percutaneous coronary intervention (PCI), greater stent thrombosis, and increased target vessel revascularization. Women undergoing PCI are more often older than men and likely to present with severe lesion calcification. The ORBIT II study, for the first time compares the effect of the orbital atherectomy system (OAS) in men and women undergoing PCI for severely calcified lesions. Although the adjusted risk of severe dissections was higher in women, the incidence of in-hospital and 30-day outcomes was similar to men. Randomized comparisons of the OAS with rotational atherectomy and with stenting without atherectomy are needed to further elucidate sex-based differences in calcified lesion PCI.
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Jaya
authors.initials: J
authors.lastname: Chandrasekhar
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, New York.|Cardiovascular Research Foundation, New York, New York.
authors.forename: Roxana
authors.initials: R
authors.lastname: Mehran
mesh_terms: D017073:Atherectomy; D017225:Atherectomy, Coronary; D005260:Female; D006801:Humans; D008297:Male; D062645:Percutaneous Coronary Intervention; D016896:Treatment Outcome; D061205:Vascular Calcification