title: [The results of the multicenter pharmaco-epidemiological observational project on the use of mydocalm in the treatment of pain syndromes with the muscle spasm].
abstract: The prospective multicenter open noncomparative pharmaco-epidemiological observational project on the use of mydocalm in real clinical practice has been completed in 2013. The project has been performed in 2090 clinical/rehabilitation settings in 284 cities of 13 countries using the results of 35,383 patients. The project aimed to assess the safety of treatment (percentage of patients with adverse-effects) and pain relieving efficacy as well as patient's satisfaction with the treatment. In total, 6603 (19%) adverse-effects were recorded. Their severity was evaluated as mild in 84,48%, no serious adverse-effects were noted. The high efficacy of mydocalm in the treatment of pain syndromes with the muscle spasm has been demonstrated. The high level of tolerability and absence of the clinically significant increase of adverse effects in the combination with nonsteroidal anti-inflammatory drugs have been confirmed.
authors.affiliation: Ural State Medical University, Ekaterinburg, Ural State Medical Academy, Ekaterinburg, Rostov State Medical University, Rostov-on-Don, Yaroslavl State Medical Academy, Yaroslsvl, Kazan State Medical Academy, Kazan, V.F.Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Kazan State Medical University, Kazan, Irkutsk State Institute for Postgraduate Education, Irkutsk, Volga Federal Medical Research Center, Nizhny Novgorod, Pirogov Russian National Research Medical University, Moscow, Soloviev Research and Practical Psychoneurological Center, Moscow Department of Public Health, Moscow, Pavlov St.-Petersburg State Medical University, St.-Petersburg.
authors.forename: A A
authors.initials: AA
authors.lastname: Skoromets
authors.affiliation: .
authors.forename: A B
authors.initials: AB
authors.lastname: Guekht
authors.forename: D V
authors.initials: DV
authors.lastname: Galanov
authors.forename: O A
authors.initials: OA
authors.lastname: Danilenko
authors.affiliation: Ural State Medical University, Ekaterinburg, Ural State Medical Academy, Ekaterinburg, Rostov State Medical University, Rostov-on-Don, Yaroslavl State Medical Academy, Yaroslsvl, Kazan State Medical Academy, Kazan, V.F.Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Kazan State Medical University, Kazan, Irkutsk State Institute for Postgraduate Education, Irkutsk, Volga Federal Medical Research Center, Nizhny Novgorod, Pirogov Russian National Research Medical University, Moscow, Soloviev Research and Practical Psychoneurological Center, Moscow Department of Public Health, Moscow, Pavlov St.-Petersburg State Medical University, St.-Petersburg.
authors.forename: E R
authors.initials: ER
authors.lastname: Barantsevich
authors.forename: A V
authors.initials: AV
authors.lastname: Lebedeva
authors.affiliation: Tashkent Medical Institute for Postgraduate Education, Tashkent, Uzbekistan.
authors.forename: A N
authors.initials: AN
authors.lastname: Belova
authors.forename: V V
authors.initials: VV
authors.lastname: Shprakh
authors.forename: E I
authors.initials: EI
authors.lastname: Bogdanov
authors.forename: S V
authors.initials: SV
authors.lastname: Prokopenko
authors.forename: F A
authors.initials: FA
authors.lastname: Khabirov
authors.forename: N N
authors.initials: NN
authors.lastname: Spirin
authors.forename: V A
authors.initials: VA
authors.lastname: Baliazin
authors.forename: V S
authors.initials: VS
authors.lastname: Miakotnykh
authors.forename: L I
authors.initials: LI
authors.lastname: Volkova
authors.forename: B G
authors.initials: BG
authors.lastname: Gafurov
authors.forename: T S
authors.initials: TS
authors.lastname: Mishchenko
authors.affiliation: Insitute of Neurology, Psychiatry and Narcology, National Ukranian Academy of Medical Sciences, Kharkiv, Ukraine.
authors.forename: Ch T
authors.initials: CT
authors.lastname: Toktomushev
authors.affiliation: Kirghiz State Medical Institute for Postgraguate Training, Bishkek, Kirghizia.
authors.forename: R K
authors.initials: RK
authors.lastname: Shyralieva
authors.affiliation: Azerbaijan State Institute for Postgraduate Education, Baku, Azerbaijan.
authors.forename: S K
authors.initials: SK
authors.lastname: Musaev
authors.affiliation: Azerbaijan Medical University, Baku, Azerbaijan ,Research Institute of Medical Rehabilitation, Baku, Azerbaijan.
authors.forename: S G
authors.initials: SG
authors.lastname: Guseinov
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D009125:Muscle Relaxants, Central / Q000009:adverse effects / Q000627:therapeutic use; D010146:Pain / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D017891:Pharmacoepidemiology; D011446:Prospective Studies; D013035:Spasm / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D013577:Syndrome; D014049:Tolperisone / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome; D016032:Randomized Controlled Trials as Topic
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009125:Muscle Relaxants, Central; D014049:Tolperisone