title: Clinical applications of decellularized extracellular matrices for tissue engineering and regenerative medicine.
abstract: Decellularization is the process of removing the cellular components from tissues or organs. It is a promising technology for obtaining a biomaterial with a highly preserved extracellular matrix (ECM), which may also act as a biological scaffold for tissue engineering and regenerative therapies. Decellularized products are gaining clinical importance and market space due to their ease of standardized production, constant availability for grafting and mechanical or biochemical superiority against competing clinical options, yielding clinical results ahead of the ones with autografts in some applications. Current drawbacks and limitations of traditional treatments and clinical applications can be overcome by using decellularized or acellular matrices. Several companies are leading the market with versatile acellular products designed for diverse use in the reconstruction of tissues and organs. This review describes ECM-based decellularized and acellular products that are currently in use for different branches of clinic.
authors.affiliation: Ankara University Faculty of Science, and Ankara University Stem Cell Institute, Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Parmaksiz
authors.forename: Arin
authors.initials: A
authors.lastname: Dogan
authors.forename: Sedat
authors.initials: S
authors.lastname: Odabas
authors.forename: A Eser
authors.initials: AE
authors.lastname: Elçin
authors.forename: Y Murat
authors.initials: YM
authors.lastname: Elçin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D005109:Extracellular Matrix; D006801:Humans; D019651:Plastic Surgery Procedures; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials