title: Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities.
abstract: Great progress has been made in many areas of pediatric oncology. However, tumors of the central nervous system (CNS) remain a significant challenge. A recent explosion of data has led to an opportunity to understand better the molecular basis of these diseases and is already providing a foundation for the pursuit of rationally chosen therapeutics targeting relevant molecular pathways. The molecular biology of pediatric brain tumors is shifting from a singular focus on basic scientific discovery to a platform upon which insights are being translated into therapies.
authors.affiliation: Departments of †Genetics **Pediatrics ‡Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Hanover, NH *Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda §Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center ∥Division of Pediatric Oncology, Johns Hopkins School of Medicine, Bloomberg Children's Hospital, Baltimore, MD ¶The Brain Tumor Institute #Division of Hematology-Oncology, Children's National Medical Center, Washington, DC.
authors.forename: John
authors.initials: J
authors.lastname: Glod
authors.forename: Gilbert J
authors.initials: GJ
authors.lastname: Rahme
authors.forename: Harpreet
authors.initials: H
authors.lastname: Kaur
authors.forename: Eric
authors.initials: E
authors.lastname: H Raabe
authors.forename: Eugene I
authors.initials: EI
authors.lastname: Hwang
authors.forename: Mark A
authors.initials: MA
authors.lastname: Israel
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy; D016543:Central Nervous System Neoplasms / Q000473:pathology / Q000628:therapy; D002648:Child; D005910:Glioma; D006801:Humans; D008527:Medulloblastoma; D008967:Molecular Biology / Q000379:methods / Q000639:trends