title: [Risk factors for hearing impairment induced by cytomegalovirus infection].
abstract: OBJECTIVE
  To investigate the risk factors for hearing impairment induced by cytomegalovirus (CMV) infection in children.
  
  
  METHODS
  One hundred and fifty-eight children diagnosed with CMV infection were enrolled as subjects. Based on the results of the brainstem auditory evoked potential (BAEP) test, patients were classified into normal hearing group (n=117; BAEP≤35) and abnormal hearing group (n=41; BAEP>35). A retrospective analysis was performed on the general information, routine blood indices, liver function, copy number of CMV-DNA in urine and breast milk. The receiver operating characteristic (ROC) curve was used to predict the copy number of CMV-DNA resulting in abnormal BAEP. The Spearman rank correlation analysis was used to test the correlations of the copy number of CMV-DNA in urine with the degree of hearing impairment and platelet count.
  
  
  RESULTS
  The incidence rates of platelet abnormality and abnormal liver function and the copy number of CMV-DNA in urine were significantly higher in the abnormal hearing group than in the normal hearing group (P<0.01). According to the ROC curve, the copy number of CMV-DNA in urine had a sensitivity of 46.3% and a specificity of 93.2% in predicting hearing impairment when it reached 1.415×10(6) per mL. The results of correlation analysis showed that the degree of hearing impairment was positively correlated with the copy number of CMV-DNA (r=0.382, P<0.01); the platelet count was negatively correlated with the copy number of CMV-DNA in urine (r=-0.233, P=0.003).
  
  
  CONCLUSIONS
  An increased copy number of CMV-DNA in urine might be a risk factor for hearing impairment induced by CMV infection. Children are likely to have hearing impairment when the copy number of CMV-DNA reaches 1.415×10(6) per mL. The monitoring of hearing should be strengthened in CMV-infected children with a decreased platelet count.
authors.affiliation: Department of Neonatology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China. yuantm@hotmail.com.
authors.forename: Mei-Juan
authors.initials: MJ
authors.lastname: Zhang
authors.forename: Tian-Ming
authors.initials: TM
authors.lastname: Yuan
authors.forename: Li-Zhen
authors.initials: LZ
authors.lastname: Wang
mesh_terms: D003586:Cytomegalovirus Infections / Q000150:complications*; D004279:DNA, Viral / Q000652:urine; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D034381:Hearing Loss / Q000209:etiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010976:Platelet Count; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D004279:DNA, Viral