title: Metabolic stressors disrupt proteome homeostasis to suppress malignancy.
abstract: Within tumor cells the heat shock factor 1 (HSF1)-mediated stress response is constitutively mobilized to counter persistent proteotoxic stress, hence sustaining their fragile proteome homeostasis and supporting robust malignant phenotypes. Intriguingly, our new studies reveal that metabolic stressors, such as metformin, inactivate HSF1 and provoke proteomic chaos, thereby impeding tumorigenesis.
authors.affiliation: The Jackson Laboratory, Bar Harbor, ME 04609, USA.
authors.forename: Chengkai
authors.initials: C
authors.lastname: Dai
keywords: AMPK; HSF1; glucose deprivation; metabolic stress; metformin; proteostasis; proteotoxic stress; tumor suppression; ubiquitination