title: Zygotic Genome Activators, Developmental Timing, and Pluripotency.
abstract: The transcription factors Pou5f1, Sox2, and Nanog are central regulators of pluripotency in mammalian ES and iPS cells. In vertebrate embryos, Pou5f1/3, SoxB1, and Nanog control zygotic genome activation and participate in lineage decisions. We review the current knowledge of the roles of these genes in developing vertebrate embryos from fish to mammals and suggest a model for pluripotency gene regulatory network functions in early development.
authors.affiliation: Developmental Biology Unit, Institute Biology I, Faculty of Biology, and Center for Biological Signaling Studies (BIOSS), Albert-Ludwigs-University, Freiburg, Germany. Electronic address: onichtchouk@biologie.uni-freiburg.de.
authors.forename: Daria
authors.initials: D
authors.lastname: Onichtchouk
authors.affiliation: Developmental Biology Unit, Institute Biology I, Faculty of Biology, and Center for Biological Signaling Studies (BIOSS), Albert-Ludwigs-University, Freiburg, Germany. Electronic address: driever@biologie.uni-freiburg.de.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Driever
mesh_terms: D000818:Animals; D019070:Cell Lineage; D019143:Evolution, Molecular; D005260:Female; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D006801:Humans; D008322:Mammals / Q000196:embryology / Q000235:genetics; D000071317:Nanog Homeobox Protein / Q000235:genetics / Q000378:metabolism; D050814:Octamer Transcription Factor-3 / Q000235:genetics / Q000378:metabolism; D039904:Pluripotent Stem Cells; D015027:Zebrafish / Q000196:embryology / Q000235:genetics; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism; D015053:Zygote
chemical_list: D000071317:Nanog Homeobox Protein; D050814:Octamer Transcription Factor-3; C494174:Pou5f1 protein, mouse; C085437:Pou5f3 protein, zebrafish; D029961:Zebrafish Proteins
keywords: Blastula; Differentiation; Embryo; Embryonic stem cells; Gene regulatory network; Oct4; Pattern formation; Pluripotency; Pou5f3; Zygotic genome activation