title: Antinociceptive activity of intraperitoneally administered novel and potent anticonvulsive compound, CY-PROLL-SS, in animal neuropathic pain models.
abstract: BACKGROUND
  Neuropathic pain is still one of the most difficult pain states to be treated due to the lack of effective drugs. Although the mechanism of action of antiepileptic drugs in alleviating neuropathic pain is not fully understood, it is believed that the bases for both diseases are similar pathophysiologic disturbances. Therefore, in this article we explored the analgesic potential of a recently discovered compound CY-PROLL-SS (ADD 408003; 4-phenyl-perhydropyrrole[1,2-a]pyrazine-1,3-dione) with proved anticonvulsant activity.
  
  
  METHODS
  CY-PROLL-SS was delivered to animals systemically to assess the antinociceptive effects either in streptozocin (STZ)-induced diabetic or in chronic constriction injury (CCI) models of neuropathic pain after acute exposure to both thermal and mechanical stimulus.
  
  
  RESULTS
  Examined here compound dose-dependently reversed thermal and mechanical hyperalgesia induced by STZ single injection. Similar results were obtained for CCI-induced hyperalgesia; however, in this case an attenuation of thermal and reversal of mechanical hyperalgesia were observed.
  
  
  CONCLUSIONS
  High doses of CY-PROLL-SS considerably alleviate peripheral neuropathic pain in model of STZ diabetic neuropathy and CCI. However, mechanisms remain to be elucidated.
authors.affiliation: Department of Pharmacodynamics, Centre for Preclinical Research and Technology Medical University of Warsaw, Warszawa , Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Bujalska-Zadrożny
authors.affiliation: Department of Pharmacodynamics, Centre for Preclinical Research and Technology Medical University of Warsaw, Warszawa , Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Kogut
authors.affiliation: Department of Pharmacodynamics, Centre for Preclinical Research and Technology Medical University of Warsaw, Warszawa , Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: de Cordé
authors.affiliation: Department of Drug Technology and Pharmaceutical Biotechnology, Medical University of Warsaw, Warszawa , Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Dawidowski
authors.affiliation: Department of Pharmacodynamics, Centre for Preclinical Research and Technology Medical University of Warsaw, Warszawa , Poland. Electronic address: hazufiel@wp.pl.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Kleczkowska
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D008297:Male; D009437:Neuralgia / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects*; D011719:Pyrazines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013311:Streptozocin
chemical_list: C000620771:4-phenyl-perhydropyrrole(1,2-a)pyrazine-1,3-dione; D000700:Analgesics; D000927:Anticonvulsants; D011719:Pyrazines; D011758:Pyrroles; D013311:Streptozocin
keywords: Analgesia; Neuropathic pain; Streptozotocin