title: EEG in postanoxic coma: Prognostic and diagnostic value.
abstract: Evolution of the EEG background pattern is a robust contributor to prediction of poor or good outcome of comatose patients after cardiac arrest. At 24h, persistent isoelectricity, low voltage activity, or burst-suppression with identical bursts predicts a poor outcome without false positives. Rapid recovery toward continuous patterns within 12h is strongly associated with a good neurological outcome. Predictive values are highest in the first 24h, despite the use of mild therapeutic hypothermia and sedative medication. Studies on reactivity or mismatch negativity have not included the EEG background pattern. Therefore, the additional predictive value of reactivity parameters remains unclear. Whether or not treatment of electrographic status epilepticus improves outcome is studied in the randomized multicenter Treatment of Electroencephalographic STatus epilepticus After cardiopulmonary Resuscitation (TELSTAR) trial (NCT02056236).
authors.affiliation: Clinical Neurophysiology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands; Department of Neurology, Rijnstate Hospital, Arnhem, The Netherlands. Electronic address: jhofmeijer@rijnstate.nl.
authors.forename: J
authors.initials: J
authors.lastname: Hofmeijer
authors.affiliation: Clinical Neurophysiology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands; Department of Clinical Neurophysiology, Medisch Spectrum Twente, Enschede, The Netherlands. Electronic address: M.J.A.M.vanPutten@utwente.nl.
authors.forename: M J A M
authors.initials: MJ
authors.lastname: van Putten
mesh_terms: D003128:Coma / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D004569:Electroencephalography / Q000639:trends*; D006323:Heart Arrest / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D015337:Multicenter Studies as Topic / Q000379:methods; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic / Q000379:methods
keywords: EEG; Electrographic status epilepticus; Outcome prediction; Postanoxic coma; Postanoxic encephalopathy