title: Practical Considerations and the Intestinal Microbiome in Disease: Antibiotics for IBD Therapy.
abstract: The inflammatory bowel diseases, Crohn's and ulcerative colitis, have been treated with a range of antibiotics for inducing and maintaining remission, as well as the prevention of post-operative symptoms. To date, many studies have been performed assessing the efficacy of antibiotics when used alone, in combination with other antibiotics, or as an adjunctive therapy to other pharmaceutical treatments. Literature evidence supporting the use of antibiotics in IBD can be ambiguous, especially when considering the potential role of dysbiosis in the gastrointestinal tract. The review considers the systemic effect of antibiotics and the evidence base for their efficacy in the treatment of IBD.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta., Canada.
authors.forename: Richard N
authors.initials: RN
authors.lastname: Fedorak
authors.forename: Kathleen P
authors.initials: KP
authors.lastname: Ismond
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000906:Antibodies / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000382:microbiology; D003424:Crohn Disease / Q000188:drug therapy / Q000382:microbiology; D000069196:Gastrointestinal Microbiome; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D000906:Antibodies