title: PET Mapping of Neurofunctional Changes in a Posttraumatic Stress Disorder Model.
abstract: Posttraumatic stress disorder (PTSD) is an anxiety disorder that occurs after exposure to a traumatic event. This study aimed to investigate the neurobiologic changes before and after exposure-based therapy by PET in a rat model of PTSD.
  
  
  
  Serial (18)F-FDG PET imaging studies were performed under the control (tone presentation), fear-conditioning, and extinction retrieval phases. Neuroactivity marker c-Fos protein was used for immunostaining.
  
  
  
  Increased glucose metabolism was observed in the bilateral amygdala after fear-conditioning (P < 0.001) and in the right posterior insular cortex under extinction retrieval (P < 0.001) compared with the control phase. Increased c-Fos expression in the posterior insular cortex under extinction retrieval was positively correlated to the glucose metabolism (P < 0.01).
  
  
  
  Our results indicated that the amygdala plays a key role in fear memory formation and, most importantly, the insular cortex is related to the retrieval of extinction memory. (18)F-FDG PET may provide a promising in vivo approach for evaluating exposure-based therapy of PTSD.
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and.
authors.forename: Yunqi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and meitian@zju.edu.cn.
authors.forename: Ruili
authors.initials: R
authors.lastname: Du
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and.
authors.forename: Yuankai
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and.
authors.forename: Yehua
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and.
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and.
authors.forename: Fahuan
authors.initials: F
authors.lastname: Song
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China meitian@zju.edu.cn.
authors.forename: Mei
authors.initials: M
authors.lastname: Tian
mesh_terms: D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013313:Stress Disorders, Post-Traumatic / Q000000981:diagnostic imaging* / Q000503:physiopathology*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: extinction; fear conditioning; positron emission tomography (PET); post-traumatic stress disorder (PTSD)