title: Decreased Cathepsin K Plasma Level may Reflect an Association of Osteopoenia/Osteoporosis with Coronary Atherosclerosis and Coronary Artery Calcification in Male Patients with Stable Angina.
abstract: BACKGROUND
  The aim of this study was to evaluate the plasma levels of bone turnover markers (BTMs) in male patients with stable angina depending on the bone mineral density (BMD), coronary atherosclerosis (CA) and coronary artery calcification (CAC).
  
  
  METHODS
  We recruited 112 males with verified stable angina. All the patients underwent coronary angiography, multislice spiral computed tomography, and dual-energy X-ray absorptiometry. Plasma levels of BTMs were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Osteopoenia and osteoporosis were reported in 90 (80.4%) and 34 (30.4%) patients, respectively. Multivessel coronary artery disease, severe CA and CAC, decreased cathepsin K plasma level, and increased osteocalcin plasma level were significantly more prevalent in patients with osteopoenia/osteoporosis compared to the subjects with normal BMD. Patients with severe CA and CAC had significantly reduced cathepsin K plasma levels.
  
  
  CONCLUSIONS
  We revealed a significant association of osteopoenia/osteoporosis with severe CA and CAC in males with stable angina. Cathepsin K and osteocalcin plasma levels may be suggested as the significant markers of osteopoenia/osteoporosis. In addition, cathepsin K plasma level can be also a valuable marker of severe CA and CAC.
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation.
authors.forename: Olga L
authors.initials: OL
authors.lastname: Barbarash
authors.affiliation: Kemerovo State Medical Academy, Kemerovo, Russian Federation.
authors.forename: Natalia B
authors.initials: NB
authors.lastname: Lebedeva
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation.
authors.forename: Alexandr N
authors.initials: AN
authors.lastname: Kokov
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation.
authors.forename: Anastasia A
authors.initials: AA
authors.lastname: Novitskaya
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation.
authors.forename: Oksana N
authors.initials: ON
authors.lastname: Hryachkova
authors.affiliation: Kemerovo State Medical Academy, Kemerovo, Russian Federation.
authors.forename: Anna V
authors.initials: AV
authors.lastname: Voronkina
authors.affiliation: Kemerovo State Medical Academy, Kemerovo, Russian Federation.
authors.forename: Tatiana A
authors.initials: TA
authors.lastname: Raskina
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation.
authors.forename: Vasiliy V
authors.initials: VV
authors.lastname: Kashtalap
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation. Electronic address: antonkutikhin@gmail.com.
authors.forename: Anton G
authors.initials: AG
authors.lastname: Kutikhin
authors.affiliation: Regional Clinical Hospital for War Veterans, Kemerovo, Russian Federation.
authors.forename: Irina A
authors.initials: IA
authors.lastname: Shibanova
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D060050:Angina, Stable / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D056657:Cathepsin K / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging; D036542:Tomography, Spiral Computed; D061205:Vascular Calcification / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology
chemical_list: D015415:Biomarkers; C534130:CTSK protein, human; D056657:Cathepsin K
keywords: Calcification; Cathepsin K; Osteocalcin; Osteopoenia/osteoporosis; Stable angina