title: Tong Luo Jiu Nao, a Chinese Medicine Formula, Reduces Inflammatory Stress in a Mouse Model of Alzheimer's Disease.
abstract: The aim of this study is to extend the molecular mechanism of Tong Luo Jiu Nao (TLJN) for Alzheimer's disease (AD), which is a modern Chinese formula that has been used to treat AD.
  
  
  
  The senescence-accelerated mouse prone 8 strain (SAMP8) is one of the most appropriate models to study the mechanism that underlies AD. The levels of plasma amyloid β (Aβ) and the Aβ deposits were measured using enzyme-linked immunosorbent assay and immunohistochemistry. Immunoblotting was used to observe the effect of TLJN on inflammatory mediator expression in an senescence-accelerated mouse model of AD.
  
  
  
  Our data showed that the TLJN-treated groups exhibited a reduction in plasma Aβ levels and reduced Aβ expression. Moreover, TLJN effectively attenuated Aβ-induced activation of extracellular signal-regulated kinase and c-Jun N-terminal kinases and blocked changes in inflammatory mediator expression.
  
  
  
  These data suggest that TLJN might have protective effects and could potentially act to attenuate inflammatory stress in the pathogenesis of AD.
authors.affiliation: School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Nan Kai District, Tianjin, China School of Basic Medicine, Hena university of Traditional Chinese Medicine, Jin Shui District, Zhengzhou, China.
authors.forename: Ai-She
authors.initials: AS
authors.lastname: Gao
authors.affiliation: School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Nan Kai District, Tianjin, China duhuan0420@tjutcm.edu.cn.
authors.forename: Huan
authors.initials: H
authors.lastname: Du
authors.affiliation: School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Nan Kai District, Tianjin, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Gao
authors.affiliation: School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Nan Kai District, Tianjin, China.
authors.forename: Yi-Jing
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: School of Basic Medicine, Hena university of Traditional Chinese Medicine, Jin Shui District, Zhengzhou, China.
authors.forename: Xie-Yan
authors.initials: XY
authors.lastname: Wang
authors.affiliation: School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Nan Kai District, Tianjin, China.
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Liu
authors.affiliation: School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Nan Kai District, Tianjin, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Lu
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000097:blood / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D007249:Inflammation; D051379:Mice
chemical_list: D016229:Amyloid beta-Peptides; D004365:Drugs, Chinese Herbal; C528243:tongluo jiunao
keywords: Aβ; SAMP8 mice; Tong Luo Jiu Nao; inflammatory mediator