title: End-Stage Renal Disease From Cast Nephropathy in a Teenager With Neuroendocrine Carcinoma.
abstract: Cast nephropathy is the most common manifestation of renal injury in patients with multiple myeloma but is rarely reported in other conditions. We are reporting our experience in caring for a teenager with a metastatic neuroendocrine carcinoma who developed rapidly progressive kidney injury that advanced to end-stage renal disease. On renal biopsy extensive tubular necrosis and intratubular eosinophilic casts were noted. This previously unreported finding should prompt oncologists to closely monitor for such a complication in patients with secretory tumors. Whether early plasmapheresis could be of benefit, as has been tried in multiple myeloma, remains to be determined.
authors.affiliation: Departments of *Pediatrics, Section of Pediatric Nephrology †Pediatrics, Division of Pediatric Hematology and Oncology, University of California Davis Medical Center, Sacramento, CA.
authors.forename: Lavjay
authors.initials: L
authors.lastname: Butani
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ducore
mesh_terms: D000293:Adolescent; D000818:Animals; D001706:Biopsy; D018278:Carcinoma, Neuroendocrine / Q000150:complications* / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D007668:Kidney / Q000293:injuries*; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008297:Male; D009362:Neoplasm Metastasis