title: The prevalence of neuromuscular disease in the paediatric population in Yorkshire, UK; variation by ethnicity and deprivation status.
abstract: Previous studies suggest a higher prevalence of neurological disease within certain ethnic communities, but have not specifically considered neuromuscular diseases (NMDs). The aim of this study was to calculate the prevalence and relationship of NMDs to ethnicity and deprivation status.
  
  
  
  We undertook a retrospective case-note review of those younger than 16 years with a confirmed diagnosis of NMD in a single centre in Yorkshire in 2010.
  
  
  
  Two-hundred and sixty-one cases were included. The population (0-16y) in Yorkshire was 707 961. The overall prevalence was 36.9 per 100 000 (95% confidence interval [CI] 34.6-39.1). Dystrophin-related muscle disease was the most common condition, with a prevalence of 16.9 per 100 000 males (95% CI 14.7-19.1). There was a significant difference between ethnic groups, with a total NMD prevalence of 91.2 per 100 000 (95% CI 81.6-100.7) in the South Asian ethnic group compared with 28.7 per 100 000 (95% CI 26.4-30.9) in the White group. Prevalence of non-dystrophin-related NMDs was four times higher in South Asian than in White children. There was a linear relation between increased prevalence and increased deprivation.
  
  
  
  This study confirms higher levels of NMD, particularly recessively inherited NMDs within the South Asian population, as well as a link with higher deprivation. This has implications for service provision and resource allocation.
authors.affiliation: Department of Paediatric Neurology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Woodcock
authors.affiliation: Department of Health Sciences, University of York, York, UK.
authors.forename: Lorna
authors.initials: L
authors.lastname: Fraser
authors.affiliation: School of Geography, University of Leeds, Leeds, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Norman
authors.affiliation: Department of Paediatric Neurology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
authors.forename: Karen
authors.initials: K
authors.lastname: Pysden
authors.affiliation: Department of Paediatric Neurology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
authors.forename: Sue
authors.initials: S
authors.lastname: Manning
authors.affiliation: Department of Paediatric Neurology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Childs
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000706:statistics & numerical data*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009468:Neuromuscular Diseases / Q000453:epidemiology / Q000208:ethnology / Q000523:psychology; D015995:Prevalence; D011610:Psychosocial Deprivation; D012189:Retrospective Studies; D006113:United Kingdom / Q000453:epidemiology / Q000208:ethnology; D044465:White People / Q000706:statistics & numerical data*