title: Effectiveness of estrogen treatment before transcervical resection of adhesions on moderate and severe uterine adhesion patients.
abstract: Intrauterine adhesion (IUA), also known as Asherman's syndrome, is a common disease for among women. The extent of adhesion and pre-surgery hormone therapy greatly affects the function of uterine cavity. This current study investigates the association of different doses of estrogen before transcervical resection of adhesions (TCRA) surgery and clinical outcome in serious IUA. About 120 newly diagnostic serious IUA patients who underwent TCRA were randomly divided into three study groups: Estradiol valerate (progynova) 3 or 9 mg per diet before surgery and the control group. Follow-up hysteroscopy checkups were taken in 1- and 3-month post-operation. The effective power of 9 mg group was significantly higher than other groups. The 9 mg group achieved the best menstrual recovery rate in all study groups compared with the other two groups in 6 months post-operatively (p < 0.05). Our results confirmed estradiol valerateas an alternative effective drug for the prevention of IUAs before and after hysteroscopic surgery.
authors.affiliation: a Department of Gynecology and Obstetrics , Woman and Infant Hospital of Zhengzhou , Zhengzhou , Henan , P.R. China.
authors.forename: Ai-Zhen
authors.initials: AZ
authors.lastname: Liu
authors.affiliation: a Department of Gynecology and Obstetrics , Woman and Infant Hospital of Zhengzhou , Zhengzhou , Henan , P.R. China.
authors.forename: Hong-Guo
authors.initials: HG
authors.lastname: Zhao
authors.affiliation: a Department of Gynecology and Obstetrics , Woman and Infant Hospital of Zhengzhou , Zhengzhou , Henan , P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.affiliation: a Department of Gynecology and Obstetrics , Woman and Infant Hospital of Zhengzhou , Zhengzhou , Henan , P.R. China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.affiliation: a Department of Gynecology and Obstetrics , Woman and Infant Hospital of Zhengzhou , Zhengzhou , Henan , P.R. China.
authors.forename: Bao-Zhi
authors.initials: BZ
authors.lastname: Guo
mesh_terms: D000328:Adult; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004967:Estrogens / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006175:Gynatresia / Q000517:prevention & control* / Q000601:surgery*; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D004967:Estrogens; D004958:Estradiol
keywords: Estradiol valerate; hysteroscopy; intrauterine adhesions