title: Bevacizumab Plus Irinotecan Versus Temozolomide in Newly Diagnosed O6-Methylguanine-DNA Methyltransferase Nonmethylated Glioblastoma: The Randomized GLARIUS Trial.
abstract: In patients with newly diagnosed glioblastoma that harbors a nonmethylated O(6)-methylguanine-DNA methyltransferase promotor, standard temozolomide (TMZ) has, at best, limited efficacy. The GLARIUS trial thus explored bevacizumab plus irinotecan (BEV+IRI) as an alternative to TMZ.
  
  
  
  In this phase II, unblinded trial 182 patients in 22 centers were randomly assigned 2:1 to BEV (10 mg/kg every 2 weeks) during radiotherapy (RT) followed by maintenance BEV (10 mg/kg every 2 weeks) plus IRI(125 mg/m(2) every 2 weeks) or to daily TMZ (75 mg/m(2)) during RT followed by six courses of TMZ (150-200 mg/m(2)/d for 5 days every 4 weeks). The primary end point was the progression-free survival rate after 6 months (PFS-6).
  
  
  
  In the modified intention-to-treat (ITT) population, PFS-6 was increased from 42.6% with TMZ (95% CI, 29.4% to 55.8%) to 79.3% with BEV+IRI (95% CI, 71.9% to 86.7%; P <.001). PFS was prolonged from a median of 5.99 months (95% CI, 2.7 to 7.3 months) to 9.7 months (95% CI, 8.7 to 10.8 months; P < .001). At progression, crossover BEV therapy was given to 81.8% of all patients who received any sort of second-line therapy in the TMZ arm. Overall survival (OS) was not different in the two arms: the median OS was 16.6 months (95% CI, 15.4 to 18.4 months) with BEV+IRI and was 17.5 months (95% CI, 15.1 to 20.5 months) with TMZ. The time course of quality of life (QOL) in six selected domains of the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire (QLQ) -C30 and QLQ-BN20 (which included cognitive functioning), of the Karnofsky performance score, and of the Mini Mental State Examination score was not different between the treatment arms.
  
  
  
  BEV+IRI resulted in a superior PFS-6 rate and median PFS compared with TMZ. However, BEV+IRI did not improve OS, potentially because of the high crossover rate. BEV+IRI did not alter QOL compared with TMZ.
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany ulrich.herrlinger@ukb.uni-bonn.de.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Herrlinger
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Niklas
authors.initials: N
authors.lastname: Schäfer
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Joachim P
authors.initials: JP
authors.lastname: Steinbach
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Astrid
authors.initials: A
authors.lastname: Weyerbrock
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Hau
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Goldbrunner
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Friedrich
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Veit
authors.initials: V
authors.lastname: Rohde
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Ringel
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Schlegel
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Sabel
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Ronellenfitsch
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Uhl
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Maciaczyk
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Grau
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Schnell
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Hänel
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Dietmar
authors.initials: D
authors.lastname: Krex
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Vajkoczy
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Gerlach
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Rolf-Dieter
authors.initials: RD
authors.lastname: Kortmann
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Mehdorn
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Tüttenberg
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Regine
authors.initials: R
authors.lastname: Mayer-Steinacker
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Fietkau
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Brehmer
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Frederic
authors.initials: F
authors.lastname: Mack
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Stuplich
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Sied
authors.initials: S
authors.lastname: Kebir
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Kohnen
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Elmar
authors.initials: E
authors.lastname: Dunkl
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Leutgeb
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Proescholdt
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Torsten
authors.initials: T
authors.lastname: Pietsch
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Horst
authors.initials: H
authors.lastname: Urbach
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Claus
authors.initials: C
authors.lastname: Belka
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Stummer
authors.affiliation: Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Glas
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000008:administration & dosage; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000235:genetics / Q000378:metabolism; D045643:DNA Repair Enzymes / Q000235:genetics / Q000378:metabolism; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005909:Glioblastoma / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000532:radiotherapy; D006801:Humans; D000077146:Irinotecan; D008297:Male; D008875:Middle Aged; D011401:Promoter Regions, Genetic; D000077204:Temozolomide; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D025521:Tumor Suppressor Proteins; D000068258:Bevacizumab; D000077146:Irinotecan; D003606:Dacarbazine; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes; D002166:Camptothecin; D000077204:Temozolomide