title: Therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats.
abstract: The aim of this study was to explore the therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats. Rats were fed high-fat fodder to establish a rat fatty liver model, and were then fed different concentrations of Pleurotus eryngii cellulose for six weeks. Lipitor was used as a positive control. Measured levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), and total triglyceride (TG); the activity of malondialdehyde (MDA), superoxide dismutase (SOD), hepatic lipase (HL), and lipoprotein lipase; and liver histopathological changes. Successfully established rat fatty liver model after feeding high-fat fodder for one week. A diet of P. eryngii cellulose for six weeks significantly reduced ALT, AST, TC, and TG levels in rat serum (P < 0.01); TC and AST levels in P. eryngii cellulose high-dose group and Lipitor group were not significantly different from those of the control (P > 0.05). SOD activity increased significantly, while MDA and HL activity decreased (P < 0.05); fatty degeneration and fat accumulation both decreased in hepatic tissue. Hepatic protection of P. eryngii cellulose showed dose-related effect. P. eryngii cellulose can affect lipid metabolism, having therapeutic effects on fatty liver in rats.
authors.affiliation: Engineering Technological Center of Mushroom Industry, Minnan Normal University, Zhangzhou, Fujian, China.
authors.forename: J F
authors.initials: JF
authors.lastname: Huang
authors.affiliation: Engineering Technological Center of Mushroom Industry, Minnan Normal University, Zhangzhou, Fujian, China.
authors.forename: T
authors.initials: T
authors.lastname: Zhan
authors.affiliation: Engineering Technological Center of Mushroom Industry, Minnan Normal University, Zhangzhou, Fujian, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Yu
authors.affiliation: Engineering Technological Center of Mushroom Industry, Minnan Normal University, Zhangzhou, Fujian, China.
authors.forename: Q A
authors.initials: QA
authors.lastname: He
authors.affiliation: Engineering Technological Center of Mushroom Industry, Minnan Normal University, Zhangzhou, Fujian, China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Huang
authors.affiliation: Engineering Technological Center of Mushroom Industry, Minnan Normal University, Zhangzhou, Fujian, China.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Lin
authors.affiliation: Engineering Technological Center of Mushroom Industry, Minnan Normal University, Zhangzhou, Fujian, China.
authors.forename: Y T
authors.initials: YT
authors.lastname: Du
authors.affiliation: Engineering Technological Center of Mushroom Industry, Minnan Normal University, Zhangzhou, Fujian, China.
authors.forename: Y T
authors.initials: YT
authors.lastname: Pan
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002482:Cellulose / Q000494:pharmacology* / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000097:blood / Q000188:drug therapy*; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects; D008297:Male; D020076:Pleurotus; D051381:Rats; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002482:Cellulose; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase