title: Isolated anti-Ro/SSA thrombocytopenia: a rare feature of neonatal lupus.
abstract: We report a rare case of isolated thrombocytopenia related to anti-Ro/SSA antibodies. The mother was followed for unlabeled familial thrombocytopenia. The mother had positive anti-Ro/SSA antibodies. She was asymptomatic without skin lesions or other criteria neither of systemic lupus erythematosus nor other connective tissue disease. Pregnancy was uneventful. The postnatal examination was normal. On the first day of life, blood cells count showed thrombocytopenia at 40 x 10(9)/L. Within the second day of life, platelet level dropped to 20 x 10(9)/L. The management of thrombocytopenia included platelet transfusion and human immunoglobulin infusion. On the fifth day of life, there has been a drop in platelet count to 10 x 10(9)/L requiring renewed platelet transfusion and human immunoglobulin infusion. On the 10(th) of life platelets rate was stable around 60 x 10(9)/L. The infant had no evidence of cardiac, dermatologic or hepatobilary involvement initially or throughout follow up.
authors.affiliation: Department of Neonatology, Charles Nicolle Hospital, Tunis-El Manar University, Tunis, Tunisia.
authors.forename: Imene Dahmane
authors.initials: ID
authors.lastname: Ayadi
authors.affiliation: Department of Neonatology, Charles Nicolle Hospital, Tunis-El Manar University, Tunis, Tunisia.
authors.forename: Emira
authors.initials: E
authors.lastname: Ben Hamida
authors.affiliation: Department of Neonatology, Charles Nicolle Hospital, Tunis-El Manar University, Tunis, Tunisia.
authors.forename: Mohamed Riadh
authors.initials: MR
authors.lastname: Boukhris
authors.affiliation: Department of Neonatology, Charles Nicolle Hospital, Tunis-El Manar University, Tunis, Tunisia.
authors.forename: Ahlem
authors.initials: A
authors.lastname: Bezzine
authors.affiliation: Department of Neonatology, Charles Nicolle Hospital, Tunis-El Manar University, Tunis, Tunisia.
authors.forename: Sihem
authors.initials: S
authors.lastname: Chaouachi
authors.affiliation: Department of Neonatology, Charles Nicolle Hospital, Tunis-El Manar University, Tunis, Tunisia.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Marrakchi
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000151:congenital*; D008297:Male; D013921:Thrombocytopenia / Q000209:etiology* / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; C035356:SS-A antibodies
keywords: Neonatal lupus erythematosus; anti-Ro/SSA; thrombocytopenia