title: Microtubule plus-end tracking proteins in neuronal development.
abstract: Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal development and function. One such regulatory mechanism centers on microtubule plus-end tracking proteins (+TIPs): structurally and functionally diverse regulatory factors, which can form complex macromolecular assemblies at the growing microtubule plus-ends. +TIPs modulate important properties of microtubules including their dynamics and their ability to control cell polarity, membrane transport and signaling. Several neurodevelopmental and neurodegenerative diseases are associated with mutations in +TIPs or with misregulation of these proteins. In this review, we focus on the role and regulation of +TIPs in neuronal development and associated disorders.
authors.affiliation: Cell Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
authors.forename: Dieudonnée
authors.initials: D
authors.lastname: van de Willige
authors.affiliation: Cell Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands. c.hoogenraad@uu.nl.
authors.forename: Casper C
authors.initials: CC
authors.lastname: Hoogenraad
authors.affiliation: Cell Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands. a.akhmanova@uu.nl.
authors.forename: Anna
authors.initials: A
authors.lastname: Akhmanova
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology; D000818:Animals; D001369:Axons / Q000378:metabolism; D001927:Brain Diseases / Q000473:pathology; D002462:Cell Membrane / Q000378:metabolism; D016764:Cell Polarity; D003599:Cytoskeleton / Q000378:metabolism; D003712:Dendrites / Q000378:metabolism; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism / Q000502:physiology*; D009154:Mutation; D016501:Neurites / Q000378:metabolism; D055495:Neurogenesis / Q000502:physiology; D009474:Neurons / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D011485:Protein Binding; D015398:Signal Transduction; D013569:Synapses / Q000378:metabolism
chemical_list: D008869:Microtubule-Associated Proteins
keywords: CLASP; CLIP; Cytoskeleton; Development; EB; Microtubule; Neuron; Plus-end tracking proteins; Polarity