title: MicroRNA and extracellular vesicles in glioblastoma: small but powerful.
abstract: To promote the tumor growth, angiogenesis, metabolism, and invasion, glioblastoma (GBM) cells subvert the surrounding microenvironment by influencing the endogenous activity of other brain cells including endothelial cells, macrophages, astrocytes, and microglia. Large number of studies indicates that the intra-cellular communication between the different cell types of the GBM microenvironment occurs through the functional transfer of oncogenic components such as proteins, non-coding RNAs, DNA and lipids via the release and uptake of extracellular vesicles (EVs). Unlike the communication through the secretion of chemokines and cytokines, the transfer and gene silencing activity of microRNAs through EVs is more complex as the biogenesis and proper packaging of microRNAs is crucial for their uptake by recipient cells. Although the specific mechanism of EV-derived microRNA uptake and processing in recipient cells is largely unknown, the screening, identifying and finally targeting of the EV-associated pro-tumorigenic microRNAs are emerging as new therapeutic strategy to combat the GBM.
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 4 Blackfan Circle, Boston, MA, 02115, USA.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Rooj
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 4 Blackfan Circle, Boston, MA, 02115, USA.
authors.forename: Marco
authors.initials: M
authors.lastname: Mineo
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 4 Blackfan Circle, Boston, MA, 02115, USA. jgodlewski@partners.org.
authors.forename: Jakub
authors.initials: J
authors.lastname: Godlewski
mesh_terms: D001932:Brain Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D049109:Cell Proliferation / Q000235:genetics; D000067128:Extracellular Vesicles / Q000378:metabolism*; D020868:Gene Silencing; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D009389:Neovascularization, Pathologic / Q000235:genetics; D059016:Tumor Microenvironment / Q000235:genetics
chemical_list: D035683:MicroRNAs
keywords: Exosomes; Extracellular vesicles; Glioblastoma; microRNA