title: [Study and Evaluation on Preparation of Monolithic Osmotic Pump Tablet of Resveratrol].
abstract: OBJECTIVE
  To prepare monolithic osmotic pump tablet of resveratrol.
  
  
  METHODS
  Inclusion technology was adopted to enhance its solubility. The optimal formulation of resveratrol inclusion complex osmotic pump tablets was selected by the single-factor method and orthogonal design. The release in vitro of the optimized formulation was also fitted to different models.
  
  
  RESULTS
  The tablets with optimized formulation achieved the desired zero-order release profile in 12 h (r = 0.9963) with the cumulative release over 90%.
  
  
  CONCLUSIONS
  Resveratrol can be prepared into monolithic osmotic pump tablets based on the intermediate of inclusion technology, which have obvious characteristic of zero release.
authors.forename: Xian-chuang
authors.initials: XC
authors.lastname: Wu
authors.forename: Hai-jun
authors.initials: HJ
authors.lastname: Hao
authors.forename: Xiao-yong
authors.initials: XY
authors.lastname: Song
authors.forename: Yong-zhou
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Yu-xin
authors.initials: YX
authors.lastname: Liu
authors.forename: Hong-qin
authors.initials: HQ
authors.lastname: Zhang
mesh_terms: D002626:Chemistry, Pharmaceutical; D009995:Osmosis; D000077185:Resveratrol; D012995:Solubility; D013267:Stilbenes / Q000737:chemistry*; D013607:Tablets
chemical_list: D013267:Stilbenes; D013607:Tablets; D000077185:Resveratrol