title: [STUDYING THE ROLE OF BRAIN MELANOCORTIN RECEPTORS IN THE SUPPRESSING OF FOOD INTAKE UNDER ETHER STRESS IN MICE].
abstract: Melanocortin (MC) system regulates food intake under the rest conditions. Stress inhibits food intake. It is not clear whether brain MC system is involved in stress-induced anorexia in mice. The aim of the work was to investigate the effect of pharmacological blockade and activation of brain MC receptors on food intake under stress. C57B1/6J male mice were subjected to ether stress (0.5 minute ether anesthesia) before the administration of saline solution or synthetic non-selective blocker (SHU9119) or agonist (Melanotan II) of MC receptors into the lateral brain ventricle. Food intake was pre-stimulated with 17 hours of fasting in all mice. Ether stress decreased food intake, increased the plasma corticosterone level and hypothalamic mRNA AgRP (natural MC receptor antagonist) level at 1 hour after the stress. Pharmacological blockade of the MC receptors weakened stress-induced anorexia and decreased mRNA AgRP level in the hypothalamus. Pharmacological stimulation of the MC receptors enhanced ether stress-induced anorexia and hypercortisolism. Thus, our data demonstrated that the central MC system was involved in the development of stress-induced anorexia in mice.
authors.forename: N M
authors.initials: NM
authors.lastname: Bazhan
authors.forename: E V
authors.initials: EV
authors.lastname: Kulikova
authors.forename: E N
authors.initials: EN
authors.lastname: Makarova
authors.forename: T V
authors.initials: TV
authors.lastname: Yakovleva
authors.forename: A Yu
authors.initials: AY
authors.lastname: Kazantseva
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004435:Eating / Q000187:drug effects*; D004986:Ether / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D051379:Mice; D044101:Receptors, Melanocortin / Q000378:metabolism*; D013312:Stress, Physiological / Q000187:drug effects*
chemical_list: D044101:Receptors, Melanocortin; D004986:Ether