title: Nightly oral administration of topiramate for benign childhood epilepsy with centrotemporal spikes.
abstract: OBJECTIVE
  The objective of this study was to explore the feasibility of nightly oral administration of topiramate for treating benign childhood epilepsy with centrotemporal spikes (BECTS).
  
  
  METHODS
  Eighty-five children with BECTS receiving topiramate treatment were randomly divided into A group (44 patients) and B group (41 patients). In A group, topiramate was orally administrated once a night, with a final dose of 2 mg/kg/day. In B group, topiramate was orally administrated twice a day, with a final dose of 4 mg/kg/day. At the end of the 12-month follow-up period, clinical efficacy, changes in electroencephalographic (EEG) activity, and adverse reactions were analyzed.
  
  
  RESULTS
  There was no significant difference in overall efficacy rate, percentages of patients achieving seizure free, or changes in EEG activity between the two groups (P > 0.05). The rate of adverse reactions for A group was 9.1 %, which was significantly lower than the 29.3 % for B group (χ (2) = 4.262, P < 0.05).
  
  
  CONCLUSIONS
  Nightly oral administration of topiramate is a feasible strategy for the treatment of BECTS, with the advantages of comparable efficacy, convenience, and fewer adverse reactions.
authors.affiliation: Department of Pediatrics, People's Hospital of Yucheng, Yucheng, 251200, China.
authors.forename: Chunrong
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, People's Hospital of Yucheng, Yucheng, 251200, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Song
authors.affiliation: Department of Neurology, Shanghai Children's Medical Center, Shanghai Jiaotong University, Shanghai, 200127, China. docjiwenwang@163.com.
authors.forename: Jiwen
authors.initials: J
authors.lastname: Wang
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D004569:Electroencephalography; D019305:Epilepsy, Rolandic / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D000077236:Topiramate; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose
keywords: Benign childhood epilepsy; Therapy; Topiramate; Treatment