title: Adiponectin: a versatile player of innate immunity.
abstract: Adiponectin acts as a key regulator of the innate immune system and plays a major role in the progression of inflammation and metabolic disorders. Macrophages and monocytes are representative components of the innate immune system, and their proliferation, plasticity, and polarization are a key component of metabolic adaption. Innate-like lymphocytes such as group 2 innate lymphoid cells (ILC2s), natural killer T (NKT) cells, and gamma delta T (γδ T) cells are also members of the innate immune system and play important roles in the development of obesity and its related diseases. Adiponectin senses metabolic stress and modulates metabolic adaption by targeting the innate immune system under physiological and pathological conditions. Defining the mechanisms underlying the role of adiponectin in regulating innate immunity is crucial to adiponectin-based therapeutic intervention.
authors.affiliation: Institute of Metabolism and Endocrinology, Metabolic Syndrome Research Center, the Second Xiangya Hospital, Central South University, Changsha 410011, China Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Institute of Metabolism and Endocrinology, Metabolic Syndrome Research Center, the Second Xiangya Hospital, Central South University, Changsha 410011, China Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA meilianliu@salud.unm.edu.
authors.forename: Meilian
authors.initials: M
authors.lastname: Liu
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000818:Animals; D016764:Cell Polarity; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000166:cytology; D008264:Macrophages / Q000166:cytology; D009504:Neutrophils / Q000166:cytology
chemical_list: D052242:Adiponectin
keywords: adiponectin; innate immunity; innate-like lymphocyte; macrophage