title: Risk Factors for New-Onset Cardiac Valve Calcification in Patients on Maintenance Peritoneal Dialysis.
abstract: OBJECTIVE
  Patients with end-stage renal disease are susceptible to cardiac valve calcification (CVC) due to mineral metabolism disorders and other factors. The purpose of this study was to investigate the risk factors for new-onset CVC in patients on maintenance peritoneal dialysis (PD).
  
  
  METHODS
  This study included patients who underwent PD catheter insertion from January 2006 to June 2013 in our Peritoneal Dialysis Center. Clinical data were collected on CVC status during echocardiography evaluations (twice) at an interval of >6 months. The data collected included intact parathyroid hormone, C-reactive protein (CRP), serum phosphorus (P), serum calcium (Ca), albumin (Alb), prealbumin and the use of five types of antihypertensive drugs, statins, active vitamin D3 and Ca tablets.
  
  
  RESULTS
  In total, 194 patients - 105 (54.1%) men, average age 60.5 ± 13.0 years - were included. CVC was present in 50 (25.8%) patients during PD catheter placement. After an average PD duration of 20.9 ± 10.4 months, CVC was detected in 97 patients (50.0%). New-onset CVC was found in 62 patients (32.0%). Multivariate logistic regression analysis revealed that only serum P levels (p = 0.01, OR = 2.569), Alb levels (p = 0.04, OR = 0.935), dialysis duration (p = 0.03, OR = 1.039) and CRP levels (p = 0.02, OR = 1.031) were associated with CVC.
  
  
  CONCLUSIONS
  Serum P, Alb and CRP levels as well as dialysis duration are independent risk factors for CVC.
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Yunhuan
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Feng
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Zhoubing
authors.initials: Z
authors.lastname: Zhan
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Yancai
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Song
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Huaying
authors.initials: H
authors.lastname: Shen
keywords: Cardiac valve calcification; Peritoneal dialysis; Risk factor