title: Adipose tissue hypoxia and insulin resistance.
abstract: Despite the well-established association of obesity with insulin resistance and inflammation, the underlying mechanisms and sequence of events leading to inflammation and insulin resistance remain unknown. Adipose tissue hypoxia has been proposed as one of the possible key events during the process of fat expansion that leads to adipose tissue dysfunction. The focus of this paper is reviewing the evidence on adipose tissue hypoxia in obesity and its relation to insulin resistance.
authors.affiliation: Division of Endocrinology, Metabolism and Diabetes, University of Colorado, School of Medicine, Aurora, Colorado, USA VA Eastern Colorado Health Care System, Denver, Colorado, USA.
authors.forename: Neda
authors.initials: N
authors.lastname: Rasouli
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D000860:Hypoxia / Q000473:pathology*; D007333:Insulin Resistance; D009765:Obesity / Q000473:pathology
keywords: Hypoxia; Obesity