title: Signaling in Host-Associated Microbial Communities.
abstract: Human-associated microbiota form and stabilize communities based on interspecies interactions. We review how these microbe-microbe and microbe-host interactions are communicated to shape communities over a human's lifespan, including periods of health and disease. Modeling and dissecting signaling in host-associated communities is crucial to understand their function and will open the door to therapies that prevent or correct microbial community dysfunction to promote health and treat disease.
authors.affiliation: Department of Bioengineering and Therapeutic Sciences and California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: fischbach@fischbachgroup.org.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Fischbach
authors.affiliation: Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA. Electronic address: jsegre@nhgri.nih.gov.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Segre
mesh_terms: D000818:Animals; D001419:Bacteria / Q000145:classification / Q000378:metabolism; D006801:Humans; D056265:Microbial Interactions; D064307:Microbiota; D015398:Signal Transduction