title: Magnetic resonance imaging and cell-based neurorestorative therapy after brain injury.
abstract: Restorative cell-based therapies for experimental brain injury, such as stroke and traumatic brain injury, substantially improve functional outcome. We discuss and review state of the art magnetic resonance imaging methodologies and their applications related to cell-based treatment after brain injury. We focus on the potential of magnetic resonance imaging technique and its associated challenges to obtain useful new information related to cell migration, distribution, and quantitation, as well as vascular and neuronal remodeling in response to cell-based therapy after brain injury. The noninvasive nature of imaging might more readily help with translation of cell-based therapy from the laboratory to the clinic.
authors.affiliation: Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.
authors.forename: Quan
authors.identifier: 0000-0001-7908-4443
authors.initials: Q
authors.lastname: Jiang
keywords: MRI; angiogenesis; axonal remodeling; blood brain barrier permeability; cell labeling; cell therapy; cerebral blood flow; cerebral blood volume; diffusion tensor MRI; neuronal plasticity; stroke; traumatic brain injury; vascular remodeling