title: [Oxidative stress in adipose tissue as a primary link in pathogenesis of insulin resistance].
abstract: Obesity is a leading risk factor of diabetes mellitus type 2, impairments of lipid metabolism and cardiovascular diseases. Dysfunctions of the accumulating weight of the visceral fat are primarily linked to pathogenesis of systemic insulin resistance. The review considers modern views about biochemical mechanisms underlying formation of oxidative stress in adipocytes at obesity, as one of key elements of impairments of their metabolism triggering formation of systemic insulin resistance.
authors.affiliation: Siberian State Medical University, Тоmsk, Russia.
authors.forename: D I
authors.initials: DI
authors.lastname: Kuzmenko
authors.affiliation: Siberian State Medical University, Тоmsk, Russia.
authors.forename: S N
authors.initials: SN
authors.lastname: Udintsev
authors.affiliation: Siberian State Medical University, Тоmsk, Russia.
authors.forename: T K
authors.initials: TK
authors.lastname: Klimentyeva
authors.affiliation: Siberian State Medical University, Тоmsk, Russia.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Serebrov
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress
keywords: adipocyte; diabetes; insulin resistance; oxidative stress