title: Histopathology of NET: Current concepts and new developments.
abstract: The diagnosis of neuroendocrine tumors is based on their histopathologic appearance and immunohistochemical profile. With the WHO 2010 classification formal staging and grading was introduced for gastro-entero-pancreatic NET, however, the nomenclature for lung neuroendocrine tumors still relies on the carcinoid term. In this review we also focus on the situation of neuroendocrine carcinoma of unknown primary, tissue biomarkers and actual controversies in the histopathology of NEN.
authors.affiliation: Institute of Pathology, University of Bern, Murtenstrasse 31, 3010, Bern, Switzerland. Electronic address: anja.schmitt@pathology.unibe.ch.
authors.forename: Anja M
authors.initials: AM
authors.lastname: Schmitt
authors.affiliation: Institute of Pathology, University of Bern, Murtenstrasse 31, 3010, Bern, Switzerland. Electronic address: annika.blank@pathology.unibe.ch.
authors.forename: Annika
authors.initials: A
authors.lastname: Blank
authors.affiliation: Institute of Pathology, University of Bern, Murtenstrasse 31, 3010, Bern, Switzerland. Electronic address: ilaria.marinoni@pathology.unibe.ch.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Marinoni
authors.affiliation: Institute of Pathology, Triemli City Hospital, Birmensdorferstrasse 497, 8063, Zürich, Switzerland. Electronic address: paul.komminoth@triemli.stzh.ch.
authors.forename: Paul
authors.initials: P
authors.lastname: Komminoth
authors.affiliation: Institute of Pathology, University of Bern, Murtenstrasse 31, 3010, Bern, Switzerland. Electronic address: aurel.perren@pathology.unibe.ch.
authors.forename: Aurel
authors.initials: A
authors.lastname: Perren
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018278:Carcinoma, Neuroendocrine / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D060787:Neoplasm Grading / Q000379:methods; D009367:Neoplasm Staging / Q000379:methods; D018358:Neuroendocrine Tumors / Q000145:classification / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: NEC; NET; WHO; biomarker; carcinoid; classification; grading; histopathology; immunohistochemistry; neuroendocrine tumor