title: Splenic angiomyxoma with intravascular tumor embolus in a dog: a case report.
abstract: A 13-year-old castrated male Yorkshire terrier dog had a soft splenic mass, which measured 11 cm in the greatest diameter. Microscopically, the parenchyma of the spleen was completely replaced by myxoid substances. Numerous spindle and stellate cells were loosely arranged in the myxoid stroma, and variable vessels of variable sizes were observed in a loose matrix with poorly defined margins. Immunohistochemical analysis showed that tumor cells were positive for desmin and alpha-SMA, but negative for S-100. Interestingly, intravascular tumor embolus with positive α-SMA expression was observed. This case is meaningful, because angiomyxoma, a rare tumor of dogs, occurs in the spleen. Even in human cases, splenic angiomyxoma was not reported.
authors.affiliation: Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, 41566, Republic of Korea.
authors.forename: Eun-Mi
authors.initials: EM
authors.lastname: Lee
authors.forename: Ah-Young
authors.initials: AY
authors.lastname: Kim
authors.forename: Eun-Joo
authors.initials: EJ
authors.lastname: Lee
authors.forename: Jin-Kyu
authors.initials: JK
authors.lastname: Park
authors.forename: Tae-Hwan
authors.initials: TH
authors.lastname: Kim
authors.forename: Se-Il
authors.initials: SI
authors.lastname: Park
authors.forename: Kyu-Shik
authors.initials: KS
authors.lastname: Jeong
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D008297:Male; D009232:Myxoma / Q000473:pathology / Q000662:veterinary*; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D013154:Spleen / Q000473:pathology; D013160:Splenic Neoplasms / Q000473:pathology / Q000662:veterinary*