title: Automated interferometric synthetic aperture microscopy and computational adaptive optics for improved optical coherence tomography.
abstract: In this paper, we introduce an algorithm framework for the automation of interferometric synthetic aperture microscopy (ISAM). Under this framework, common processing steps such as dispersion correction, Fourier domain resampling, and computational adaptive optics aberration correction are carried out as metrics-assisted parameter search problems. We further present the results of this algorithm applied to phantom and biological tissue samples and compare with manually adjusted results. With the automated algorithm, near-optimal ISAM reconstruction can be achieved without manual adjustment. At the same time, the technical barrier for the nonexpert using ISAM imaging is also significantly lowered.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.forename: Yuan-Zhi
authors.initials: YZ
authors.lastname: Liu
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Boppart
authors.forename: P Scott
authors.initials: PS
authors.lastname: Carney
mesh_terms: D000465:Algorithms; D001331:Automation; D006801:Humans; D008857:Microscopy, Interference / Q000379:methods*; D055095:Optics and Photonics / Q000379:methods*; D019047:Phantoms, Imaging; D012867:Skin / Q000033:anatomy & histology; D041623:Tomography, Optical Coherence / Q000379:methods*