title: Candidate gene variants of the immune system and sudden infant death syndrome.
abstract: BACKGROUND
  Sudden infant death syndrome (SIDS) causes early infant death with an incidence between 0.5 and 2.5 cases among 1000 live births. Besides central sleep apnea and thermal dysregulation, infections have been repeatedly suggested to be implicated in SIDS etiology.
  
  
  METHODS
  To test the risk contribution of common genetic variants related to infection, we genotyped 40 single-nucleotide polymorphisms (SNPs) from 15 candidate genes for association with SIDS in a total of 579 cases and 1124 controls from Germany and the UK in a two-stage case control design.
  
  
  RESULTS
  The discovery-stage series (267 SIDS cases and 303 controls) revealed nominally significant associations for variants in interleukin 6 (IL6) (rs1880243), interleukin 10 (IL10) (rs1800871, rs1800872), and mannose-binding lectin 2 (MBL2) (rs930506), and for several other variants in subgroups. Meta-analyses were then performed in adding genotype information from a genome-wide association study of another 312 European SIDS cases and 821 controls. Overall associations were observed for two independent variants in MBL2: rs930506 in a co-dominant model (odds ratio (OR) = 0.82, p = 0.04) and rs1838065 in a dominant model (OR = 1.27, p = 0.03).
  
  
  CONCLUSIONS
  Our study did not replicate published associations of IL10 variants with SIDS. However, the evidence for two independent MBL2 variants in the combined analysis of two large series seems consistent with the hypothesis that infection may play a role in SIDS pathogenesis.
authors.affiliation: Institute of Legal Medicine, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
authors.forename: Delnaz
authors.initials: D
authors.lastname: Fard
authors.affiliation: Institute of Legal Medicine, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Läer
authors.affiliation: Institute of Legal Medicine, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Rothämel
authors.affiliation: Gynaecology Research Unit, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Schürmann
authors.affiliation: Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Arnold
authors.affiliation: Sheffield Children's Hospital NHS Trust, Western Bank, Sheffield, S10 2TH, UK.
authors.forename: Marta
authors.initials: M
authors.lastname: Cohen
authors.affiliation: Institute of Legal Medicine, Universität Münster, Roentgenstr. 23, 48149, Münster, Germany.
authors.forename: Mechtild
authors.initials: M
authors.lastname: Vennemann
authors.affiliation: Institute of Legal Medicine, Universität Münster, Roentgenstr. 23, 48149, Münster, Germany.
authors.forename: Heidi
authors.initials: H
authors.lastname: Pfeiffer
authors.affiliation: Institut of Legal Medicine, Universität Essen, Hufelandstr. 55, 45122, Essen, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bajanowski
authors.affiliation: Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Pfeufer
authors.affiliation: Gynaecology Research Unit, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
authors.forename: Thilo
authors.initials: T
authors.lastname: Dörk
authors.affiliation: Institute of Legal Medicine, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany. Klintschar.Michael@mh-hannover.de.
authors.forename: Michael
authors.identifier: http://orcid.org/0000-0001-8036-571X
authors.initials: M
authors.lastname: Klintschar
mesh_terms: D016022:Case-Control Studies; D005260:Female; D053803:Forensic Genetics; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016753:Interleukin-10 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013398:Sudden Infant Death / Q000235:genetics*
chemical_list: D015850:Interleukin-6; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin; D016753:Interleukin-10
keywords: Association study; Genetic predisposition; Infection; Mannose-binding lectin; Polymorphism; SIDS