title: Origanum vulgare and Thymbra capitata Essential Oils from Spain: Determination of Aromatic Profile and Bioactivities.
abstract: Oregano (Thymbra capitata and Origanum vulgare) essential oils (EOs), cultivated and extracted in the South-East of Spain, were analysed by GC/MS to determine their composition. (E)-β-Caryophyllene (0.5-4.9%), thymol (0.2-5.8%), p-cymene (3.8-8.2%), γ-terpinene (2.1-10.7%) and carvacrol (58.7-77.4%) were determined as the main molecules. This characterisation was completed with enantioselective gas chromatography, where (-)-(E)-β-caryophyllene, (+)-a- pinene and (+)-β-pinene were determined as the main enantiomers. Antioxidant activity was evaluated positively by several methods, accounting for activity against free radicals and reducing power. Important inhibitory activity on lipoxygenase (LOX) and acetylcholinesterase (AChE) was observed supporting potential anti-inflammatory, anti-Alzheimer and insecticidal activities, mainly due to carvacrol. These properties support the potential use of oregano EOs as natural cosmetic and natural pharmaceutical ingredients.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Carrasco
authors.forename: Enrique
authors.initials: E
authors.lastname: Perez
authors.forename: Ana-Belen
authors.initials: AB
authors.lastname: Cutillas
authors.forename: Ramiro
authors.initials: R
authors.lastname: Martinez-Gutierrez
authors.forename: Virginia
authors.initials: V
authors.lastname: Tomas
authors.forename: Jose
authors.initials: J
authors.lastname: Tudela
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry*; D031341:Origanum / Q000737:chemistry*; D010084:Oxidation-Reduction; D013030:Spain; D013045:Species Specificity; D017392:Thiobarbituric Acid Reactive Substances
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D016859:Lipoxygenase Inhibitors; D009822:Oils, Volatile; D017392:Thiobarbituric Acid Reactive Substances