title: Subgingivally delivered 1.2% atorvastatin in the treatment of chronic periodontitis among smokers: a randomized, controlled clinical trial.
abstract: OBJECTIVE
  Statins are known to have a beneficial effect in the treatment of chronic periodontitis (CP). The current study was designed to investigate the effectiveness of a 1.2% atorvastatin (ATV) local drug delivery system as an adjunct to scaling and root planing (SRP) in the treatment of intrabony defects (IBD) in CP among smokers.
  
  
  METHODS
  Seventy-one smokers with CP were categorized into two treatment groups: SRP + 1.2% ATV gel and SRP + placebo gel. Clinical parameters, modified sulcus bleeding index, probing depth, and clinical attachment level were recorded at baseline before SRP and at 3, 6, and 9 months. At baseline, 6 months, and 9 months, the percentage of radiographic defect depth reduction was determined using computer-aided software.
  
  
  RESULTS
  The mean probing depth reduction and mean clinical attachment level gain were found to be greater in the ATV group than the placebo group at 3, 6, and 9 months. A significantly greater mean percentage of radiographic defect depth reduction was found in the ATV group compared to the placebo group after 9 months.
  
  
  CONCLUSIONS
  The ATV local drug delivery as an adjunct to SRP can be used in the treatment of IBD in CP among smokers.
authors.affiliation: Department of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, Bangalore, India.
authors.forename: Minal
authors.initials: M
authors.lastname: Kumari
authors.affiliation: Department of Periodontics, Dr D.Y. Patil Dental College and Hospital, Pimpri, Pune, India.
authors.forename: Santosh S
authors.initials: SS
authors.lastname: Martande
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, India.
authors.forename: Avani R
authors.initials: AR
authors.lastname: Pradeep
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000069059:Atorvastatin / Q000008:administration & dosage*; D055113:Chronic Periodontitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000628:therapy; D000073865:Cigarette Smoking / Q000009:adverse effects; D003131:Combined Modality Therapy; D012534:Dental Scaling; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010514:Periodontal Pocket; D011861:Radiography, Dental
chemical_list: D005782:Gels; D000069059:Atorvastatin
keywords: atorvastatin; chronic periodontitis; clinical trial; scaling, periodontal pocket