title: Evidence-based guidelines for treating bipolar disorder: Revised third edition recommendations from the British Association for Psychopharmacology.
abstract: The British Association for Psychopharmacology guidelines specify the scope and targets of treatment for bipolar disorder. The third version is based explicitly on the available evidence and presented, like previous Clinical Practice Guidelines, as recommendations to aid clinical decision making for practitioners: it may also serve as a source of information for patients and carers, and assist audit. The recommendations are presented together with a more detailed review of the corresponding evidence. A consensus meeting, involving experts in bipolar disorder and its treatment, reviewed key areas and considered the strength of evidence and clinical implications. The guidelines were drawn up after extensive feedback from these participants. The best evidence from randomized controlled trials and, where available, observational studies employing quasi-experimental designs was used to evaluate treatment options. The strength of recommendations has been described using the GRADE approach. The guidelines cover the diagnosis of bipolar disorder, clinical management, and strategies for the use of medicines in short-term treatment of episodes, relapse prevention and stopping treatment. The use of medication is integrated with a coherent approach to psychoeducation and behaviour change.
authors.affiliation: University Department of Psychiatry, Warneford Hospital, Oxford, UK guy.goodwin@psych.ox.ac.uk.
authors.forename: G M
authors.initials: GM
authors.lastname: Goodwin
authors.affiliation: Greater Manchester West Mental Health NHS Foundation Trust, Eccles, Manchester, UK.
authors.forename: P M
authors.initials: PM
authors.lastname: Haddad
authors.affiliation: Institute of Neuroscience, Newcastle University, UK and Northumberland Tyne and Wear NHS Foundation Trust, Newcastle, UK.
authors.forename: I N
authors.initials: IN
authors.lastname: Ferrier
authors.affiliation: Centre for Evidence Based Medicine, Nuffield Department of Primary Care Health Sciences, Radcliffe Observatory Quarter, Oxford, UK.
authors.forename: J K
authors.initials: JK
authors.lastname: Aronson
authors.affiliation: The Centre for Mental Health, Imperial College London, Du Cane Road, London, UK.
authors.forename: Trh
authors.initials: T
authors.lastname: Barnes
authors.affiliation: University Department of Psychiatry, Warneford Hospital, Oxford, UK.
authors.forename: A
authors.initials: A
authors.lastname: Cipriani
authors.affiliation: MACHS 2, Ninewells' Hospital and Medical School, Dundee, UK; now Departments of Paediatrics and Psychiatry, Faculty of Medicine, Dentistry and Health Science, University of Melbourne, Melbourne, VIC, Australia.
authors.forename: D R
authors.initials: DR
authors.lastname: Coghill
authors.affiliation: University Department of Psychiatry, Warneford Hospital, Oxford, UK.
authors.forename: S
authors.initials: S
authors.lastname: Fazel
authors.affiliation: University Department of Psychiatry, Warneford Hospital, Oxford, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Geddes
authors.affiliation: Univ. Klinik f. Psychiatrie u. Psychotherapie, Christian Doppler Klinik, Universitätsklinik der Paracelsus Medizinischen Privatuniversität (PMU), Salzburg, Christian Doppler Klinik Salzburg, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Grunze
authors.affiliation: MRC Cognition & Brain Sciences Unit, Cambridge, UK.
authors.forename: E A
authors.initials: EA
authors.lastname: Holmes
authors.affiliation: Institute of Psychiatry (Box 67), London, UK.
authors.forename: O
authors.initials: O
authors.lastname: Howes
authors.affiliation: Bipolar UK, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Hudson
authors.affiliation: Fulbourn Hospital, Cambridge, UK.
authors.forename: N
authors.initials: N
authors.lastname: Hunt
authors.affiliation: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff, UK.
authors.forename: I
authors.initials: I
authors.lastname: Jones
authors.affiliation: Northumberland, Tyne and Wear NHS Foundation Trust, Queen Elizabeth Hospital, Gateshead, Tyne and Wear, UK.
authors.forename: I C
authors.initials: IC
authors.lastname: Macmillan
authors.affiliation: Institute of Neuroscience, Newcastle University, UK and Northumberland Tyne and Wear NHS Foundation Trust, Newcastle, UK.
authors.forename: H
authors.initials: H
authors.lastname: McAllister-Williams
authors.affiliation: UCLA Semel Institute for Neuroscience and Human Behavior, Division of Child and Adolescent Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Miklowitz
authors.affiliation: Division of Psychiatry and Applied Psychology, Institute of Mental Health, University of Nottingham Innovation Park, Nottingham, UK.
authors.forename: R
authors.initials: R
authors.lastname: Morriss
authors.affiliation: MRC Integrative Epidemiology Unit, UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, UK.
authors.forename: M
authors.initials: M
authors.lastname: Munafò
authors.affiliation: Oxleas NHS Foundation Trust, Dartford, UK.
authors.forename: C
authors.initials: C
authors.lastname: Paton
authors.affiliation: Department of Psychiatry (Box 189), University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: B J
authors.initials: BJ
authors.lastname: Saharkian
authors.affiliation: University Department of Psychiatry, Warneford Hospital, Oxford, UK.
authors.forename: Kea
authors.initials: K
authors.lastname: Saunders
authors.affiliation: University Department of Psychiatry, Southampton, UK.
authors.forename: Jma
authors.initials: J
authors.lastname: Sinclair
authors.affiliation: South London and Maudsley NHS Foundation Trust, Pharmacy Department, Maudsley Hospital, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Taylor
authors.affiliation: Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Vieta
authors.affiliation: Centre for Affective Disorders, King's College London, London, UK.
authors.forename: A H
authors.initials: AH
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mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D032921:Consensus; D003937:Diagnosis, Differential; D019317:Evidence-Based Medicine; D006801:Humans; D055118:Medication Adherence; D010353:Patient Education as Topic; D017410:Practice Guidelines as Topic; D011600:Psychopharmacology; D055502:Secondary Prevention
chemical_list: D000928:Antidepressive Agents
keywords: Bipolar disorder; antidepressants; antipsychotics; cognitive behaviour therapy; evidence-based guidelines; lithium; mood stabilizers; psychoeducation; treatment