title: Turning One Cell Type into Another.
abstract: The nature of cells in early embryos may be respecified simply by exposure to inducing factors. In later stage embryos, determined cell populations do not respond to inducing factors but may be respecified by other stimuli, especially the introduction of specific transcription factors. Fully differentiated cell types are hard to respecify by any method, but some degree of success can be achieved using selected combinations of transcription factors, and this may have clinical significance in the future.
authors.affiliation: Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: slack017@umn.edu.
authors.forename: Jonathan M W
authors.initials: JM
authors.lastname: Slack
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D065150:Cellular Reprogramming; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology*
keywords: Commitment; Determination; Differentiation; Inducing factor; Metaplasia