title: Natural products from microbes associated with insects.
abstract: Here we review discoveries of secondary metabolites from microbes associated with insects. We mainly focus on natural products, where the ecological role has been at least partially elucidated, and/or the pharmaceutical properties evaluated, and on compounds with unique structural features. We demonstrate that the exploration of specific microbial-host interactions, in combination with multidisciplinary dereplication processes, has emerged as a successful strategy to identify novel chemical entities and to shed light on the ecology and evolution of defensive associations.
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology e.V., Beutenbergstrasse 11a, 07745 Jena, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Beemelmanns
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology e.V., Beutenbergstrasse 11a, 07745 Jena, Germany.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Guo
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology e.V., Beutenbergstrasse 11a, 07745 Jena, Germany.
authors.forename: Maja
authors.initials: M
authors.lastname: Rischer
authors.affiliation: Centre for Social Evolution, Section for Ecology and Evolution, Department of Biology, University of Copenhagen, Universitetsparken 15, Building 3, 1st floor, 2100 Copenhagen East, Denmark.
authors.forename: Michael
authors.initials: M
authors.lastname: Poulsen
keywords: biosynthesis; chemical ecology; natural products; secondary metabolism; structure elucidation; symbiosis