title: Endothelin-1 as a predictor of impaired glucose tolerance and type 2 diabetes--A longitudinal study in the Vara-Skövde Cohort.
abstract: We addressed whether endothelin-1, a marker of endothelial dysfunction, predicts impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) in a population study in south-western Sweden. Follow-up after 9.7 years showed an association between circulating endothelin-1 levels at baseline and development of IGT/T2DM in women but not in men.
authors.affiliation: The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: josefin.olausson@wlab.gu.se.
authors.forename: Josefin
authors.initials: J
authors.lastname: Olausson
authors.affiliation: Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: bledar.daka@allmed.gu.se.
authors.forename: Bledar
authors.initials: B
authors.lastname: Daka
authors.affiliation: Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: margareta.leonardsson-hellgren@vgregion.se.
authors.forename: Margareta I
authors.initials: MI
authors.lastname: Hellgren
authors.affiliation: Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Social Medicine and Global Health, Department of Clinical Sciences, Malmö, Lund University, Sweden. Electronic address: charlotte_a.larsson@med.lu.se.
authors.forename: Charlotte A
authors.initials: CA
authors.lastname: Larsson
authors.affiliation: Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: max.petzold@gu.se.
authors.forename: Max
authors.initials: M
authors.lastname: Petzold
authors.affiliation: Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: ulf.lindblad@gu.se.
authors.forename: Ulf
authors.initials: U
authors.lastname: Lindblad
authors.affiliation: The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: per-anders.jansson@medic.gu.se.
authors.forename: Per-Anders
authors.initials: PA
authors.lastname: Jansson
mesh_terms: D015415:Biomarkers / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D005951:Glucose Tolerance Test; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D013548:Sweden / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D019332:Endothelin-1
keywords: Endothelin-1; Impaired glucose tolerance; Sex differences; Skaraborg Project; Type 2 diabetes