title: Anti-tubercular therapy for intraocular tuberculosis: A systematic review and meta-analysis.
abstract: Intraocular tuberculosis remains a diagnostic and management conundrum for both ophthalmologists and pulmonologists. We analyze the efficacy and safety of anti-tubercular therapy (ATT) in patients with intraocular tuberculosis and factors associated with favorable outcome. Twenty-eight studies are included in this review, with a total of 1,917 patients. Nonrecurrence of inflammation was observed in pooled estimate of 84% of ATT-treated patients (95% CI 79-89). There was minimal difference in the outcome between patients treated with ATT alone (85% successful outcome; 95% CI 25-100) and those with concomitant systemic corticosteroid (82%; 95% CI 73-90). The use of ATT may be of benefit to patients with suspected intraocular tuberculosis; however, this conclusion is limited by the lack of control group analysis and standardized recruitment and treatment protocols. We propose further prospective studies to better establish the efficacy of ATT and ascertain the factors associated with favorable treatment outcomes.
authors.affiliation: Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
authors.forename: Ae Ra
authors.initials: AR
authors.lastname: Kee
authors.affiliation: Tennent Institute of Ophthalmology, NHS Greater Glasgow and Clyde, Glasgow, UK. Electronic address: juliojose.gonzalez@live.com.
authors.forename: Julio J
authors.initials: JJ
authors.lastname: Gonzalez-Lopez
authors.affiliation: Tennent Institute of Ophthalmology, NHS Greater Glasgow and Clyde, Glasgow, UK.
authors.forename: Aws
authors.initials: A
authors.lastname: Al-Hity
authors.affiliation: Royal Berkshire Hospitals NHS Foundation Trust, Reading, UK; Moorfields Eye Hospital, NHS Foundation Trust, London, UK.
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Gupta
authors.affiliation: University of Washington, Seattle, Washington, USA.
authors.forename: Cecilia S
authors.initials: CS
authors.lastname: Lee
authors.affiliation: National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
authors.forename: Dinesh Visva
authors.initials: DV
authors.lastname: Gunasekeran
authors.affiliation: School of Materials Science & Engineering, Nanyang Technological University, Singapore, Singapore.
authors.forename: Nirmal
authors.initials: N
authors.lastname: Jayabalan
authors.affiliation: Kingston and St George's University of London, Kingston, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Grant
authors.affiliation: St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.
authors.forename: Onn Min
authors.initials: OM
authors.lastname: Kon
authors.affiliation: Advance Eye Centre, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Vishali
authors.initials: V
authors.lastname: Gupta
authors.affiliation: Moorfields Eye Hospital, NHS Foundation Trust, London, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Westcott
authors.affiliation: Moorfields Eye Hospital, NHS Foundation Trust, London, UK.
authors.forename: Carlos
authors.initials: C
authors.lastname: Pavesio
authors.affiliation: National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore; School of Materials Science & Engineering, Nanyang Technological University, Singapore, Singapore; Moorfields Eye Hospital, NHS Foundation Trust, London, UK. Electronic address: rupesh_agrawal@ttsh.com.sg.
authors.forename: Rupesh
authors.initials: R
authors.lastname: Agrawal
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use*; D019468:Disease Management; D006801:Humans; D011379:Prognosis; D014392:Tuberculosis, Ocular / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D000995:Antitubercular Agents
keywords: anti-tubercular therapy; intraocular; tuberculosis; uveitis