title: Lifestyle Shapes the Dialogue between Environment, Microglia, and Adult Neurogenesis.
abstract: Lifestyle modulates brain function. Diet, stress levels, and physical exercise among other factors influence the "brain cognitive reserve", that is, the capacity of the brain to maintain a normal function when confronting neurodegenerative diseases, injury, and/or aging. This cognitive reserve relays on several cellular and molecular elements that contribute to brain plasticity allowing adaptive responses to cognitive demands, and one of its key components is the hippocampal neurogenic reserve. Hippocampal neural stem cells give rise to new neurons that integrate into the local circuitry and contribute to hippocampal functions such as memory and learning. Importantly, adult hippocampal neurogenesis is well-known to be modulated by the demands of the environment and lifestyle factors. Diet, stress, and physical exercise directly act on neural stem cells and/or their progeny, but, in addition, they may also indirectly affect neurogenesis by acting on microglia. Microglia, the guardians of the brain, rapidly sense changes in the brain milieu, and it has been recently shown that their function is affected by lifestyle factors. However, few studies have analyzed the modulatory effect of microglia on adult neurogenesis in these conditions. Here, we review the current knowledge about the dialogue maintained between microglia and the hippocampal neurogenic cascade. Understanding how the communication between microglia and hippocampal neurogenesis is affected by lifestyle choices is crucial to maintain the brain cognitive reserve and prevent the maladaptive responses that emerge during disease or injury through adulthood and aging.
authors.affiliation: Achucarro Basque Center for Neuroscience , E-48170 Zamudio, Bizkaia Spain.|Ikerbasque Foundation , E-48013 Bilbao, Bizkaia Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Valero
authors.affiliation: Achucarro Basque Center for Neuroscience , E-48170 Zamudio, Bizkaia Spain.
authors.forename: Iñaki
authors.initials: I
authors.lastname: Paris
authors.affiliation: Achucarro Basque Center for Neuroscience , E-48170 Zamudio, Bizkaia Spain.|Ikerbasque Foundation , E-48013 Bilbao, Bizkaia Spain.|University of the Basque Country EHU/UPV , E-48940 Leioa, Bizkaia Spain.
authors.forename: Amanda
authors.initials: A
authors.lastname: Sierra
mesh_terms: D000818:Animals; D058245:Cognitive Reserve / Q000502:physiology; D004777:Environment; D006624:Hippocampus / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D008019:Life Style; D017628:Microglia / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*
keywords: Adult hippocampal neurogenesis; cognitive reserve; diet; exercise; microglia; stress