title: Effect of age at rheumatoid arthritis onset on clinical, radiographic, and functional outcomes: The ESPOIR cohort.
abstract: OBJECTIVE
  To investigate whether age at disease onset determines clinical, radiographic or functional outcomes in a cohort of early RA.
  
  
  METHODS
  The ESPOIR cohort is a multicenter cohort of patients with early arthritis. We selected patients fulfilling the 2010 ACR/EULAR criteria for RA during the first 3years of follow-up. Patients were pooled into 3 groups by age at RA onset: <45years (young-onset RA [YORA]), 45 to 60years (intermediate-onset RA [IORA]) and>60years (late-onset RA [LORA]). The following outcomes were compared at baseline and during the first 3years of follow-up: Simple Disease Activity Index (SDAI) remission rate, one additional erosion, Health Assessment Questionnaire Disability Index (HAQ-DI)<0.5 and first disease-modifying anti-rheumatic drug (DMARD) continuation rate.
  
  
  RESULTS
  We included 698 patients (median [interquartile range] age 50.3 [39.8-57.2]years), 266 YORA, 314 IORA, and 118 LORA. At 1year, SDAI remission was greater for YORA than IORA and LORA (P<0.0001). Having at least one additional erosion was greater for LORA and IORA than YORA after 1year (P=0.009) and 3years (P=0.017). The proportion of patients with HAQ score<0.5 was greater for YORA than IORA and LORA at 1 (P=0.007), 2 and 3years. First DMARD continuation rate was lower for YORA than other groups during the 3years (P=0.005).
  
  
  CONCLUSIONS
  In a cohort of early RA, young age at disease onset is associated with high rate of remission at 1year, no radiographic progression at 3years and low functional score during 3-year follow-up.
authors.affiliation: Rheumatology, Toulouse University Hospital Purpan, place du Docteur-Joseph-Baylac, 31300 Toulouse, France. Electronic address: Thomaskrams@gmail.com.
authors.forename: Thomas
authors.initials: T
authors.lastname: Krams
authors.affiliation: Rheumatology, Toulouse University Hospital Purpan, place du Docteur-Joseph-Baylac, 31300 Toulouse, France; INSERM/UPS Toulouse III, UMR 1027, 31300 Toulouse, France.
authors.forename: Adeline
authors.initials: A
authors.lastname: Ruyssen-Witrand
authors.affiliation: Rheumatology, Toulouse University Hospital Purpan, place du Docteur-Joseph-Baylac, 31300 Toulouse, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Nigon
authors.affiliation: Rheumatology, Toulouse University Hospital Purpan, place du Docteur-Joseph-Baylac, 31300 Toulouse, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Degboe
authors.affiliation: Brittany University, Hopital Morvan, 29000 Brest, France.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Tobon
authors.affiliation: Rheumatology, Pitié-Salpêtrière Hospital, AP-HP, 75013 Paris, France; UPMC, institut Pierre-Louis d'épidémiologie et santé publique, GRC-08, 75013 Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Fautrel
authors.affiliation: Department of Rheumatology, University Pierre-et-Marie-Curie Paris VI, Saint-Antoine hospital, "Department Hospitalo-Universitaire Inflammation-Immunopathology-Biotherapy" (I2B), AP-HP, 75012 Paris, France; INSERM/CDR Saint-Antoine, UMRS 938, 75012 Paris, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Berenbaum
authors.affiliation: Rheumatology, Toulouse University Hospital Purpan, place du Docteur-Joseph-Baylac, 31300 Toulouse, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Cantagrel
authors.affiliation: Rheumatology, Toulouse University Hospital Purpan, place du Docteur-Joseph-Baylac, 31300 Toulouse, France; INSERM/UPS Toulouse III, UMR 1027, 31300 Toulouse, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Constantin
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D012074:Remission Induction; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D018501:Antirheumatic Agents
keywords: Clinical remission; Health Assessment Questionnaire; Radiographic progression; Radiography; Rheumatoid arthritis; Treatment modalities