title: Triterpenoids from the stems of Schisandra grandiflora and their biological activity.
abstract: One new ursane-type triterpenoid (1), named granditriol, along with 14 known compounds (2-15), was isolated from the organic extracts of Schisandra grandiflora stems. The structure of the new compound was elucidated by extensive spectroscopic methods as 28-norursa-12,17,19,21-tetraen-2α,3α,23-triol. These isolates were evaluated for anti-phytopathogenic fungi activity and cytotoxicity against human cancer cell line (HepG2). Asiatic acid (8) and 2α,3α,19α-trihydroxyurs-12-en-28-oic acid (9) inhibited the growth of two plant pathogens, Alternaria alternata and Alternaria solani. In addition, compounds 12, 15, and 11 displayed notable anti-proliferative activity against HepG2 cells. Compound 1 is the first report of 28-nortriterpenoid from the Schisandraceae family. All these were obtained from this plant for the first time.
authors.affiliation: a Shaanxi Key Laboratory of Natural Products & Chemical Biology , College of Science, Northwest A&F University , Yangling 712100 , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.affiliation: b Ningbo Entry-Exit Inspection and Quarantine Bureau Technical Center , Ningbo 315012 , China.
authors.forename: Han-Wei
authors.initials: HW
authors.lastname: Liu
authors.affiliation: a Shaanxi Key Laboratory of Natural Products & Chemical Biology , College of Science, Northwest A&F University , Yangling 712100 , China.
authors.forename: Xin
authors.initials: X
authors.lastname: Guo
authors.affiliation: a Shaanxi Key Laboratory of Natural Products & Chemical Biology , College of Science, Northwest A&F University , Yangling 712100 , China.
authors.forename: Lan
authors.initials: L
authors.lastname: Hou
authors.affiliation: a Shaanxi Key Laboratory of Natural Products & Chemical Biology , College of Science, Northwest A&F University , Yangling 712100 , China.
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Gao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C000613230:granditriol
keywords: 28-nortriterpenoid; Schisandra grandiflora; Shisandraceae; antifungal activity; cytotoxicity; triterpenoids