title: Phytochemistry and pharmacological activities of the genus Prunella.
abstract: Prunella is a genus of perennial herbaceous plants in the Labiatae family. There are approximately 15 species worldwide, distributed widely in the temperate regions and tropical mountains of Europe and Asia. In the genus Prunella, P. vulgaris is the most studied, following a several thousand-year history as a traditional antipyretic and antidotal Chinese herb. Furthermore, since ancient times, P. vulgaris has been widely used as a cool tea ingredient and consumed as a vegetable. The genus Prunella contains triterpenoids and their saponins, phenolic acids, sterols and associated glycosides, flavonoids, organic acids, volatile oil and saccharides. Modern pharmacological studies have revealed that Prunella possess antiviral, antibacterial, anti-inflammatory, immunoregulatory, anti-oxidative, anti-tumor, antihypertensive and hypoglycemic functions. The active components related to these functions are mainly triterpenoids, phenolic acids, flavonoids and polysaccharides. This review mainly summarizes recent advances in traditional usage, chemical components and pharmacological functions.
authors.affiliation: School of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
authors.forename: Yubing
authors.initials: Y
authors.lastname: Bai
authors.affiliation: School of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
authors.forename: Bohou
authors.initials: B
authors.lastname: Xia
authors.affiliation: School of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
authors.forename: Wenjian
authors.initials: W
authors.lastname: Xie
authors.affiliation: School of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
authors.forename: Yamin
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: School of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
authors.forename: Jiachi
authors.initials: J
authors.lastname: Xie
authors.affiliation: School of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
authors.forename: Hongquan
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
authors.forename: Duanfang
authors.initials: D
authors.lastname: Liao
authors.affiliation: School of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China. Electronic address: linlimeiywfx@163.com.
authors.forename: Limei
authors.initials: L
authors.lastname: Lin
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Electronic address: yujiaolong1977@aliyun.com.
authors.forename: Chun
authors.initials: C
authors.lastname: Li
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D031347:Prunella / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Chemical constituents; Pharmacological activity; Prunella genus