title: PL37: a new hope in the treatment of painful diabetic neuropathy?
abstract: Solomon Tesfaye speaks to Nick Ward, Commissioning Editor: Solomon Tesfaye, MB ChB, MD, FRCP, speaks about PL37; the first orally administered dual inhibitor of enkephalinases and its potential role in the treatment of painful diabetic neuropathy. Solomon Tesfaye is a Consultant Physician/Endocrinologist at Sheffield Teaching Hospitals and Honorary Professor of Diabetic Medicine at the University of Sheffield. His research projects include the epidemiology, risk factors, pathogenesis, CNS involvement and treatment of diabetic neuropathy and neuropathic pain. He was awarded the Prestigious Camillo Golgi Prize of the European Association for the Study of Diabetes (EASD) in 2014 for major scientific contributions in diabetic neuropathy. He has had international leadership roles including chairmanship of the International Expert Group on Diabetic Neuropathy, and of NEURODIAB (2006-2009). He is also a member of the Science and Research Committee of Diabetes UK; a review panel member for the MRC, a Board Member of the Global Quantitative Sensation Testing Society; a member of the Advisory Council of the Neuropathy Trust; and Secretary of International Insulin Foundation. He has served as a member of the MRC, JDRF, NIDDK and UK NIHR scientific review panels and as a member of a Diabetes and Neuropathic Pain Review Group for NICE.
authors.affiliation: Sheffield Teaching Hospital, Room P20, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK.|University of Sheffield, Sheffield, UK.
authors.forename: Solomon
authors.initials: S
authors.lastname: Tesfaye
mesh_terms: D000284:Administration, Oral; D035843:Biomedical Research / Q000639:trends; D002986:Clinical Trials as Topic; D003929:Diabetic Neuropathies / Q000150:complications / Q000188:drug therapy*; D004220:Disulfides / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D015260:Neprilysin / Q000037:antagonists & inhibitors*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D011437:Propylamines / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: C534222:1-(2-((1-ethoxycarbonyloxyethoxycarbonylmethyl)carbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropylamine; D004220:Disulfides; D011437:Propylamines; D015260:Neprilysin
keywords: PL37; diabetic neuropathy; dual enkephalinase inhibitor; neuropathic pain; painful diabetic neuropathy