title: Analysis of Hemogram of Radiation Workers in Tangshan, China.
abstract: OBJECTIVE
  This study aimed to investigate changes in peripheral blood cells of radiation workers and explore the impact of long-term ionizing radiation (IR) on human peripheral hemogram.
  
  
  METHODS
  With a cohort method, we selected 1,392 radiation workers (case group) and 1,430 non-health-ray-exposure history persons (control group) to detect and analyze their peripheral hemogram. FAITH3000 automatic biochemical analyzer was used for blood testing. Examination of peripheral hemogram includes the examination of white blood cells (WBCs), platelet (PLTs), red blood cells (RBCs), hemoglobin (Hb), lymphocytes (LYMs), and mononuclear cells (MOs). The data analysis was conducted with software SPSS19.0.
  
  
  RESULTS
  All the peripheral hemogram indicators (WBCs, RBCs, Hb, PLTs, LYMs, and MOs) in the case group, in accordance with the order of radiology diagnostic medical group, industrial inspection group, petroleum logging group, and radiotherapy medical group, showed a significant decreasing trend and were lower than those in the control group (all P < 0.05). Besides, with the increase of radiation seniority and accumulative radiation dose, all the peripheral hemogram indicators (WBCs, RBCs, Hb, PLTs, LYMs, and MOs) in the case group dramatically decreased and were lower than those in the control group (all P < 0.05). Seniority was in negative association with the expressions of WBCs, PLTs, RBCs, Hb, LYMs, and MOs and radiation dose with Hb, LYMs, and MOs (all P < 0.05).
  
  
  CONCLUSIONS
  Long-term IR has some effects on the health of radiation workers, thus protective measures should be further strengthened.
authors.affiliation: Central Laboratory, College of Public Health, North China University of Science and Technology, Tangshan, P.R. China. qianqingzeng804@126.com.
authors.forename: Qing-Zeng
authors.initials: QZ
authors.lastname: Qian
authors.affiliation: Central Laboratory, College of Life Sciences, North China University of Science and Technology, Tangshan, P.R. China.
authors.forename: Xiang-Ke
authors.initials: XK
authors.lastname: Cao
authors.affiliation: Central Laboratory, College of Public Health, North China University of Science and Technology, Tangshan, P.R. China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Liu
authors.affiliation: Central Laboratory, College of Public Health, North China University of Science and Technology, Tangshan, P.R. China.
authors.forename: Fu-Hai
authors.initials: FH
authors.lastname: Shen
authors.affiliation: Central Laboratory, College of Public Health, North China University of Science and Technology, Tangshan, P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Central Laboratory, College of Public Health, North China University of Science and Technology, Tangshan, P.R. China.
authors.forename: Jun-Wang
authors.initials: JW
authors.lastname: Tong
authors.affiliation: Department of Internal Medicine - Neurology, Affiliated Tangshan Worker Hospital, North China University of Science and Technology, Tangshan, P.R. China.
authors.forename: Qing-Qiang
authors.initials: QQ
authors.lastname: Qian
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006403:Hematologic Tests / Q000379:methods*; D006801:Humans; D016014:Linear Models; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D000069079:Radiation Exposure / Q000009:adverse effects*; D011839:Radiation, Ionizing
keywords: accumulative radiation dose; hemogram; indicators; ionizing radiation; radiation workers; seniority