title: Antidepressant-Like Effect of Ropren® in β-Amyloid-(25-35) Rat Model of Alzheimer's Disease with Altered Levels of Androgens.
abstract: This study elucidated the potential antidepressant-like effect of prolonged Ropren® administration (8.6 mg/kg, orally, once daily for 28 days) using a β-amyloid (25-35) rat model of Alzheimer's disease following gonadectomy. The experimental model was created by intracerebroventricular injection of β-amyloid (25-35) into gonadectomized (GDX) rats and GDX rats with testosterone propionate (TP, 0.5 mg/kg, subcutaneous, once daily, 28 days) supplementation. Ropren® was administered to the GDX rats and GDX rats treated with TP. Depression-like behavior was assessed in the forced swimming test, and the spontaneous locomotor activity was assessed using the open-field test. The corticosterone and testosterone levels in the blood serum before and after FST were measured in all experimental groups. Treatment with Ropren® significantly decreased the immobility time of GDX rats with β-amyloid (25-35) in the forced swimming test. Coadministration of Ropren® with TP exerted a markedly synergistic antidepressant-like effect in the GDX rats with β-amyloid (25-35 on the same model of depression-like behavior testing. Ropren® administered alone or together with TP significantly enhanced crossing, frequency of rearing, and grooming of the GDX rats with β-amyloid (25-35) in the open-field test. Moreover, Ropren® administered alone or together with TP significantly decreased the elevated corticosterone levels in the blood serum of GDX rats with β-amyloid (25-35) following the forced swimming test. These results indicate that Ropren® has a marked antidepressant-like effect in the experimental model of Alzheimer's disease in male rats with altered levels of androgens.
authors.affiliation: Solagran Limited, Biotechnology Company, 98-106, Moray St, South Melbourne, 3205, Australia.
authors.forename: Vagif
authors.initials: V
authors.lastname: Soultanov
authors.affiliation: Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences, 6 Emb. Makarova, St. Petersburg, 199034, Russia. julia.fedotova@mail.ru.|Laboratory of Comparative Somnology and Neuroendocrinology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, 44 Tores pr, St. Petersburg, 194223, Russia. julia.fedotova@mail.ru.|Department of Chemistry and Molecular Biology, ITMO University, 49 Kronversky pr, St. Petersburg, 197101, Russia. julia.fedotova@mail.ru.
authors.forename: Julia
authors.initials: J
authors.lastname: Fedotova
authors.affiliation: Laboratory of Functional Biochemistry of Invertebrates, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, pr. Torez 44, St. Petersburg, 194223, Russia.
authors.forename: Tamara
authors.initials: T
authors.lastname: Nikitina
authors.affiliation: Department of Wood Chemistry, State Forest Technical Academy, 5 Institutsky per, St. Petersburg, 194021, Russia.
authors.forename: Victor
authors.initials: V
authors.lastname: Roschin
authors.affiliation: Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences, 6 Emb. Makarova, St. Petersburg, 199034, Russia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Ordyan
authors.affiliation: Department of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I, No. 11, Iasi, 700506, Romania. hritcu@uaic.ro.
authors.forename: Lucian
authors.identifier: 0000-0001-6981-4174
authors.initials: L
authors.lastname: Hritcu
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000188:drug therapy*; D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000728:Androgens / Q000378:metabolism*; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003345:Corticosterone / Q000378:metabolism; D003863:Depression / Q000150:complications / Q000188:drug therapy; D004195:Disease Models, Animal; D008297:Male; D010446:Peptide Fragments / Q000633:toxicity*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D017208:Rats, Wistar; D013550:Swimming; D013739:Testosterone / Q000378:metabolism / Q000494:pharmacology
chemical_list: D016229:Amyloid beta-Peptides; D000728:Androgens; D000928:Antidepressive Agents; D010446:Peptide Fragments; D010936:Plant Extracts; C000621159:Ropren; C074636:amyloid beta-protein (25-35); D013739:Testosterone; D003345:Corticosterone
keywords: Alzheimer’s disease; Depression-like behavior; Gonadectomy; Polyprenols; Ropren®; Testosterone