title: Miscarriage and recurrent miscarriage in patients with congenital factor V deficiency: a report of six cases in Iran.
abstract: Miscarriage and recurrent miscarriage have not been reported in women with congenital factor V (FV) deficiency. Here we describe cases of both miscarriage and recurrent miscarriage in women with congenital FV deficiency (FVD). We investigated six women with FVD from the southeast of Iran who had experienced miscarriage and recurrent miscarriage. Consequent diagnosis was made by routine coagulation tests as well as FV activity and antigen assays. To evaluate the presence of an inhibitor, a mixing study via prothrombin time (PT) assay was performed. All patients were investigated, and found to be negative for antiphospholipid syndrome. Demographic data and clinical presentations were obtained by standard questionnaire. The factor assays determined that all six women were suffering from moderate FVD. One had experienced eight miscarriages, while the others experienced two (two patients), three, and four episodes. Only one patient had a single miscarriage. Three of the women experienced successful delivery without medical intervention. Miscarriage and recurrent miscarriage should be considered as possible presentations of FVD to prevent its life-threatening consequences.
authors.affiliation: Department of Pediatrics Haematology and Oncology, Ali Ebn-e Abitaleb Hospital Research Center for Children and Adolescents Health [RCCAH], Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Naderi
authors.affiliation: Department of Haematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran. sh.tabibian@gmail.com.
authors.forename: Shadi
authors.initials: S
authors.lastname: Tabibian
authors.affiliation: School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Shamsizadeh
authors.affiliation: Department of Haematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran. dorgalaleha@gmail.com.
authors.forename: Akbar
authors.initials: A
authors.lastname: Dorgalaleh
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000209:etiology*; D000022:Abortion, Spontaneous / Q000097:blood / Q000209:etiology*; D001780:Blood Coagulation Tests; D005166:Factor V Deficiency / Q000150:complications / Q000151:congenital / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007492:Iran; D011247:Pregnancy
keywords: Factor V deficiency; Miscarriage; Recurrent miscarriage