title: Intestinal Failure: Adaptation, Rehabilitation, and Transplantation.
abstract: Intestinal failure (IF) is a state in which the nutritional demands are not met by the gastrointestinal absorptive surface. A majority of IF cases are associated with short-bowel syndrome, which is a result of malabsorption after significant intestinal resection for numerous reasons, some of which include Crohn's disease, vascular thrombosis, and radiation enteritis. IF can also be caused by obstruction, dysmotility, and congenital defects. Recognition and management of IF can be challenging, given the complex nature of this condition. This review discusses the management of IF with a focus on intestinal rehabilitation, parenteral nutrition, and transplantation.
authors.affiliation: *Center for Gut Rehabilitation and Transplantation, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, OH †College of Osteopathic Medicine, Michigan State University, East Lansing, MI.
authors.forename: Shishira
authors.initials: S
authors.lastname: Bharadwaj
authors.forename: Parul
authors.initials: P
authors.lastname: Tandon
authors.forename: Krishna
authors.initials: K
authors.lastname: Meka
authors.forename: John M
authors.initials: JM
authors.lastname: Rivas
authors.forename: Andrea
authors.initials: A
authors.lastname: Jevenn
authors.forename: Ning-Tsu
authors.initials: NT
authors.lastname: Kuo
authors.forename: Ezra
authors.initials: E
authors.lastname: Steiger
mesh_terms: D006801:Humans; D007410:Intestinal Diseases / Q000503:physiopathology* / Q000534:rehabilitation; D007422:Intestines / Q000503:physiopathology* / Q000637:transplantation; D008286:Malabsorption Syndromes / Q000503:physiopathology; D010288:Parenteral Nutrition / Q000379:methods*; D012778:Short Bowel Syndrome / Q000503:physiopathology