title: ABSOLUTE PLATELET REFRACTORINESS ASSOCIATED WITH HLA ANTIBODIES: A CASE REPORT.
abstract: Refractoriness to platelet transfusion is a complex process that can be due to a diverse array of etiologies. We report a case of refractoriness in a patient with acute myelogenous leukemia (AML) and the diagnostic challenge associated with it. During the course of myeloablative therapy the patient demonstrated no response to multiple sequential platelet transfusions given to prevent the onset of bleeding complications in the setting of severe thrombocytopenia. Diagnostic evaluation revealed multiple potential underlying etiologies and contributing factors, with alloimmunity to HLA antigens determined to be the most probable cause after thorough laboratory investigation.
authors.affiliation: Dr. Vora is a resident in the Department of Pathology, LSUHSC, Shreveport, LA.
authors.forename: Moiz
authors.initials: M
authors.lastname: Vora
authors.affiliation: Dr. Ong is an Associate Professor of Clinical Pathology.
authors.forename: Menchu
authors.initials: M
authors.lastname: Ong
authors.affiliation: Dr. Al-Delfi is a resident in the Department of Pathology, LSUHSC, Shreveport, LA.
authors.forename: Firas
authors.initials: F
authors.lastname: Al-Delfi
authors.affiliation: Dr. Cruz is an instructor of Clinical Pathology.
authors.forename: Nestor
authors.initials: N
authors.lastname: Dela Cruz
authors.affiliation: Dr. Veillon is a Professor of Clinical Pathology associated with the Department of Pathology, LSUHSC-Shreveport, LA.
authors.forename: Diana
authors.initials: D
authors.lastname: Veillon
authors.affiliation: Dr. Cotelingam is a Professor of Pathology, associated with the Department of Pathology, LSUHSC-Shreveport, LA.
authors.forename: James
authors.initials: J
authors.lastname: Cotelingam
mesh_terms: D001792:Blood Platelets; D006680:HLA Antigens; D006801:Humans; D007518:Isoantibodies; D015470:Leukemia, Myeloid, Acute; D017713:Platelet Transfusion / Q000009:adverse effects; D013921:Thrombocytopenia / Q000209:etiology*
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies