title: [Nesidioblastosis (diagnosis, surgical treatment)].
abstract: BACKGROUND
  Nesidioblastosis (NB) is rare disease with organic hyperinsulinism syndrome and caused by diffuse hyperplasia and/or hypertrophy of pancreatic islands of Langerhans.
  
  
  METHODS
  The results of surgical treatment of 3 patients with NB are presented. In all patients the diagnosis was suspected at the preoperative stage and confirmed by histological examination later. Herewith in 2 patients NB was combined with insulinoma. All patients underwent corpora-caudal pancreatectomy.
  
  
  RESULTS
  In postoperative period one patient hadn't episodes of hypoglycemia for the entire follow-up period (5 months), in another patient hypoglycemic states occurred at 1.5 months after surgery. The third patient required pancreatic head extirpation at 11 days after surgery due to persistent severe course of organic hyperinsulinism. In immediate postoperative period in the same patient hyperinsular hypoglycemia was observed that pointed on extrapancreatic source of insulin secretion. However contrast-enhanced CT did not reveal any formations.
  
  
  CONCLUSIONS
  Thus, corpora-caudal pancreatectomy is preferable as surgical treatment. Results of surgical management can provide a complete regression of the symptoms, but do not guarantee absence of recurrence and even any changes in frequency and severity of hypoglycemic states.
authors.affiliation: A.V. Vishnevskiy Institute of Surgery, Health Ministry of the Russian Federation, Moscow.
authors.forename: A G
authors.initials: AG
authors.lastname: Kriger
authors.affiliation: A.V. Vishnevskiy Institute of Surgery, Health Ministry of the Russian Federation, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Smirnov
authors.affiliation: A.V. Vishnevskiy Institute of Surgery, Health Ministry of the Russian Federation, Moscow.
authors.forename: D V
authors.initials: DV
authors.lastname: Kalinin
authors.affiliation: A.V. Vishnevskiy Institute of Surgery, Health Ministry of the Russian Federation, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Glotov
authors.affiliation: A.V. Vishnevskiy Institute of Surgery, Health Ministry of the Russian Federation, Moscow.
authors.forename: S V
authors.initials: SV
authors.lastname: Berelavichus
authors.affiliation: Lipetsk Regional Hospital, Lipetsk, Russia.
authors.forename: G I
authors.initials: GI
authors.lastname: Konyaeva
authors.affiliation: A.V. Vishnevskiy Institute of Surgery, Health Ministry of the Russian Federation, Moscow.
authors.forename: A N
authors.initials: AN
authors.lastname: Lebedeva
authors.affiliation: A.V. Vishnevskiy Institute of Surgery, Health Ministry of the Russian Federation, Moscow.
authors.forename: N A
authors.initials: NA
authors.lastname: Karel'skaya
authors.affiliation: A.V. Vishnevskiy Institute of Surgery, Health Ministry of the Russian Federation, Moscow.
authors.forename: V N
authors.initials: VN
authors.lastname: Tsygankov