title: Immunocytochemical localization of kisspeptin and kisspeptin receptor in the primate testis.
abstract: Hypothalamic kisspeptin-kisspeptin receptor signalling in primates ensures the successful progression into puberty during development and maintenance of reproductive capacity during adulthood. Human testis has been shown to express high-to-moderate levels of kisspeptin and kisspeptin receptor gene expression. In this study, we aimed at characterizing the localization of kisspeptin and kisspeptin receptor in adult primate testis tissue.
  
  
  
  Immunocytochemistry was performed on paraffin-embedded testicular sections from adult rhesus monkeys and from common marmoset monkeys.
  
  
  
  Kisspeptin receptor was detected in Sertoli cells in the periphery of the seminiferous tubules in adult testes of both species. In contrast, kisspeptin was not localized in the seminiferous epithelium and was detected only in the interstitial compartment of the adult rhesus monkey testis.
  
  
  
  Kisspeptin receptor and kisspeptin are localized in the testis of Old World and New World primates.
authors.affiliation: Institute of Reproductive and Regenerative Biology, Center of Reproductive Medicine and Andrology, University Clinics, Műnster, Germany.|Department of Animal Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
authors.forename: Shahzad
authors.initials: S
authors.lastname: Irfan
authors.affiliation: Institute of Reproductive and Regenerative Biology, Center of Reproductive Medicine and Andrology, University Clinics, Műnster, Germany.|Central Animal Facility of the Faculty of Medicine, University of Münster, Münster, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Ehmcke
authors.affiliation: Department of Animal Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Shahab
authors.affiliation: Institute of Reproductive and Regenerative Biology, Center of Reproductive Medicine and Andrology, University Clinics, Műnster, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Wistuba
authors.affiliation: Institute of Reproductive and Regenerative Biology, Center of Reproductive Medicine and Andrology, University Clinics, Műnster, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Schlatt
mesh_terms: D000818:Animals; D002144:Callithrix / Q000378:metabolism*; D007150:Immunohistochemistry; D059648:Kisspeptins / Q000378:metabolism*; D008253:Macaca mulatta / Q000378:metabolism*; D008297:Male; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D012671:Seminiferous Tubules / Q000737:chemistry; D012708:Sertoli Cells / Q000737:chemistry; D013045:Species Specificity; D013737:Testis / Q000737:chemistry*
chemical_list: D059648:Kisspeptins; D043562:Receptors, G-Protein-Coupled
keywords: Callithrix jacchus; Macaca mulatta; kisspeptin; kisspeptin receptor; non-human primates; testis