title: A decade of the anaphase-promoting complex in the nervous system.
abstract: Control of protein abundance by the ubiquitin-proteasome system is essential for normal brain development and function. Just over a decade ago, the first post-mitotic function of the anaphase-promoting complex, a major cell cycle-regulated E3 ubiquitin ligase, was discovered in the control of axon growth and patterning in the mammalian brain. Since then, a large number of studies have identified additional novel roles for the anaphase-promoting complex in diverse aspects of neuronal connectivity and plasticity in the developing and mature nervous system. In this review, we discuss the functions and mechanisms of the anaphase-promoting complex in neurogenesis, glial differentiation and migration, neuronal survival and metabolism, neuronal morphogenesis, synapse formation and plasticity, and learning and memory. We also provide a perspective on future investigations of the anaphase-promoting complex in neurobiology.
authors.affiliation: Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: Ju
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: Azad
authors.initials: A
authors.lastname: Bonni
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000196:embryology; D006801:Humans; D015394:Molecular Structure; D009420:Nervous System / Q000196:embryology*; D055495:Neurogenesis / Q000502:physiology*; D013569:Synapses / Q000378:metabolism
chemical_list: D064173:Anaphase-Promoting Complex-Cyclosome
keywords: E3 ubiquitin ligase; anaphase-promoting complex; ubiquitin–proteasome system