title: L-Proline Derived Bifunctional Organocatalysts: Enantioselective Michael Addition of Dithiomalonates to trans-β-Nitroolefins.
abstract: A series of novel L-proline derived tertiary amine bifunctional organocatalysts 9 are reported, which were applied to the asymmetric Michael addition of dithiomalonates 2 to trans-β-nitroolefins 1. The reaction proceeded in high yields (up to 99%) with high enantioselectivities (up to 97% ee). The synthetic utility of this methodology was demonstrated in the short synthesis of (R)-phenibut in high yield.
authors.affiliation: Department of Chemistry, Sungkyunkwan University , Suwon 440-746, Korea.
authors.forename: Hui
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Chemistry, Sungkyunkwan University , Suwon 440-746, Korea.
authors.forename: Seung Tae
authors.initials: ST
authors.lastname: Kim
authors.affiliation: Western Seoul Center, Korea Basic Science Institute , Seoul 120-140, Korea.
authors.forename: Geum-Sook
authors.initials: GS
authors.lastname: Hwang
authors.affiliation: Department of Chemistry, Sungkyunkwan University , Suwon 440-746, Korea.
authors.forename: Do Hyun
authors.initials: DH
authors.lastname: Ryu