title: Environmental Regulation of Yersinia Pathophysiology.
abstract: Hallmarks of Yersinia pathogenesis include the ability to form biofilms on surfaces, the ability to establish close contact with eukaryotic target cells and the ability to hijack eukaryotic cell signaling and take over control of strategic cellular processes. Many of these virulence traits are already well-described. However, of equal importance is knowledge of both confined and global regulatory networks that collaborate together to dictate spatial and temporal control of virulence gene expression. This review has the purpose to incorporate historical observations with new discoveries to provide molecular insight into how some of these regulatory mechanisms respond rapidly to environmental flux to govern tight control of virulence gene expression by pathogenic Yersinia.
authors.affiliation: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences Wuhan, China.
authors.forename: Shiyun
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Microbiology, College of Medicine, Howard University Washington, DC, USA.
authors.forename: Karl M
authors.initials: KM
authors.lastname: Thompson
authors.affiliation: Umeå Centre for Microbial Research, Umeå UniversityUmeå, Sweden; Department of Molecular Biology, Umeå UniversityUmeå, Sweden.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Francis
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000596:Amino Acids / Q000378:metabolism; D018441:Biofilms / Q000254:growth & development*; D001692:Biological Transport / Q000502:physiology; D050260:Carbohydrate Metabolism / Q000502:physiology; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000378:metabolism; D053038:Quorum Sensing / Q000235:genetics; D012329:RNA, Bacterial / Q000235:genetics; D058727:RNA, Small Untranslated / Q000235:genetics; D015398:Signal Transduction; D013312:Stress, Physiological / Q000502:physiology*; D013696:Temperature; D015007:Yersinia / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology; D015009:Yersinia Infections / Q000276:immunology / Q000382:microbiology / Q000473:pathology
chemical_list: D000596:Amino Acids; D012329:RNA, Bacterial; D058727:RNA, Small Untranslated; D007501:Iron
keywords: RovA; acidity; c-di-GMP; cAMP; extracytoplasmic stress; metabolism; temperature; transition metals