title: Decreased MALL expression negatively impacts colorectal cancer patient survival.
abstract: The aim of the present study was to determine whether MALL expression is associated with colon cancer progression and patient survival. MALL mRNA expression was reduced in the tumor tissues of 70% of the colon cancer patients and 75% of the rectal cancer patients as compared to their normal tissues. MALL protein was also significantly reduced in the tumor tissues of colon cancer patients (P < 0.001). Increased LOH and methylation of MALL was observed in tumor tissues as compared to normal tissues. Reduced MALL expression was associated with vessin invasion, disease recurrence and metastasis or death (P ≤ 0.027). Furthermore, patients with MALL-negative tumors had significantly decreased overall survival (OS) and disease-free survival (DFS) (P < 0.008 and P < 0.011, respectively). Univariate analysis indicated that MALL expression was significantly associated with OS and DFS. Finally, overexpression of MALL suppressed HCT116 and SW480 cell proliferation and inhibited HCT116 migration. MALL may play a role in colorectal cancer progression as suppression of its expression in tumor tissues negatively impacts colorectal cancer patient survival. Further analyses are required to determine if reduced MALL expression is due to LOH and/or methylation.
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Fan
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Fudong
authors.initials: F
authors.lastname: Yu
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Cui
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhong
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Dongwang
authors.initials: D
authors.lastname: Yan
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Chongzhi
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Guilong
authors.initials: G
authors.lastname: Deng
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xiaosheng
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Shuyun
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Qu
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Deng
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Pan
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Guohe
authors.initials: G
authors.lastname: Song
authors.affiliation: Department of Pathology, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Huamei
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Gastrointestinal Surgery, Laboratory of Digestive Surgery of State Key Laboratory of Biotherapy, West China hospital, Sichuan University, Guo Xue Xiang, Chengdu, Sichuan China.
authors.forename: Zongguang
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Zhihai
authors.initials: Z
authors.lastname: Peng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins / Q000032:analysis / Q000096:biosynthesis*; D011379:Prognosis; D016016:Proportional Hazards Models; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C110862:MALL protein, human; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins
keywords: biomarker; colorectal cancer; migration; survival