title: State of science: Choroidal thickness and systemic health.
abstract: The choroid is a highly vascular structure; therefore, a wide range of systemic conditions can affect it. Conversely, choroid health may also give us insight into systemic health. With the emergence of optical coherence tomography, there has been a surge in the research on choroidal thickness and factors affecting it. Studies regarding the effect of systemic health on the choroid have largely been in the form of cross-sectional, prospective, and case studies. We offer a summary of recent findings on the topic.
authors.affiliation: Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
authors.forename: Kara-Anne
authors.initials: KA
authors.lastname: Tan
authors.affiliation: Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore Eye Research Institute and Singapore National Eye Centre, Singapore, Singapore.
authors.forename: Preeti
authors.initials: P
authors.lastname: Gupta
authors.affiliation: Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: Department of Vitreoretina Services, L.V. Prasad Eye Institute, Hyderabad, Telangana, India.
authors.forename: Jay
authors.initials: J
authors.lastname: Chhablani
authors.affiliation: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore; Duke-NUS Graduate Medical School, Singapore, Singapore.
authors.forename: Ching-Yu
authors.initials: CY
authors.lastname: Cheng
authors.affiliation: Department of Medical Retina, Moorfields Eye Hospital, NHS Foundation Trust, London, United Kingdom.
authors.forename: Pearse A
authors.initials: PA
authors.lastname: Keane
authors.affiliation: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore; Duke-NUS Graduate Medical School, Singapore, Singapore. Electronic address: Rupesh_agrawal@ttsh.com.sg.
authors.forename: Rupesh
authors.initials: R
authors.lastname: Agrawal
mesh_terms: D002829:Choroid / Q000473:pathology*; D005128:Eye Diseases / Q000175:diagnosis* / Q000503:physiopathology; D006304:Health Status; D006801:Humans; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity
keywords: EDI-OCT; age; choroidal thickness; diurnal variation; inflammatory; metabolic; physiological; systemic disease; vascular layer