title: Spike sorting for large, dense electrode arrays.
abstract: Developments in microfabrication technology have enabled the production of neural electrode arrays with hundreds of closely spaced recording sites, and electrodes with thousands of sites are under development. These probes in principle allow the simultaneous recording of very large numbers of neurons. However, use of this technology requires the development of techniques for decoding the spike times of the recorded neurons from the raw data captured from the probes. Here we present a set of tools to solve this problem, implemented in a suite of practical, user-friendly, open-source software. We validate these methods on data from the cortex, hippocampus and thalamus of rat, mouse, macaque and marmoset, demonstrating error rates as low as 5%.
authors.affiliation: UCL Department of Neuroscience, Physiology and Pharmacology, London, UK.|UCL Institute of Neurology, London, UK.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Rossant
authors.affiliation: UCL Department of Neuroscience, Physiology and Pharmacology, London, UK.|UCL Institute of Neurology, London, UK.
authors.forename: Shabnam N
authors.initials: SN
authors.lastname: Kadir
authors.affiliation: Department of Electrical and Electronic Engineering, Imperial College, London, UK.
authors.forename: Dan F M
authors.initials: DFM
authors.lastname: Goodman
authors.affiliation: Department of Electrical Engineering and Computer Sciences, UC Berkeley, Berkeley, CA.
authors.forename: John
authors.initials: J
authors.lastname: Schulman
authors.affiliation: UCL Department of Neuroscience, Physiology and Pharmacology, London, UK.|UCL Institute of Neurology, London, UK.
authors.forename: Maximilian L D
authors.initials: MLD
authors.lastname: Hunter
authors.affiliation: UCL Institute of Ophthalmology, London, UK.
authors.forename: Aman B
authors.initials: AB
authors.lastname: Saleem
authors.affiliation: NYU Neuroscience Institute, Langone Medical Center, New York, NY.
authors.forename: Andres
authors.initials: A
authors.lastname: Grosmark
authors.affiliation: NYU Neuroscience Institute, Langone Medical Center, New York, NY.
authors.forename: Mariano
authors.initials: M
authors.lastname: Belluscio
authors.affiliation: Department of Neuroscience, Baylor College of Medicine, Houston, TX.
authors.forename: George H
authors.initials: GH
authors.lastname: Denfield
authors.affiliation: Department of Neuroscience, Baylor College of Medicine, Houston, TX.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Ecker
authors.affiliation: Department of Neuroscience, Baylor College of Medicine, Houston, TX.
authors.forename: Andreas S
authors.initials: AS
authors.lastname: Tolias
authors.affiliation: UCL Institute of Behavioural Neuroscience, Department of Experimental Psychology, London, UK.
authors.forename: Samuel
authors.initials: S
authors.lastname: Solomon
authors.affiliation: NYU Neuroscience Institute, Langone Medical Center, New York, NY.
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Buzsaki
authors.affiliation: UCL Institute of Ophthalmology, London, UK.
authors.forename: Matteo
authors.initials: M
authors.lastname: Carandini
authors.affiliation: UCL Department of Neuroscience, Physiology and Pharmacology, London, UK.|UCL Institute of Neurology, London, UK.
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Harris
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002144:Callithrix; D002540:Cerebral Cortex / Q000502:physiology*; D004567:Electrodes, Implanted; D006624:Hippocampus / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D051381:Rats; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013045:Species Specificity; D013788:Thalamus / Q000502:physiology*