title: Incidence of Acute Postoperative Endophthalmitis after Cataract Surgery: A Nationwide Study in France from 2005 to 2014.
abstract: To report the incidence of acute postoperative endophthalmitis (POE) after cataract surgery from 2005 to 2014 in France.
  
  
  
  Cohort study.
  
  
  
  Patients undergoing operation for cataract surgery by phacoemulsification and presenting acute POE.
  
  
  
  We identified acute POE occurring within 6 weeks after phacoemulsification cataract surgery and the use of intracameral antibiotic injection during the surgical procedure by means of billing codes from a national database.
  
  
  
  Incidence of acute POE.
  
  
  
  From January 2005 to December 2014, 6 371 242 eyes in 3 983 525 patients underwent phacoemulsification cataract surgery. The incidence of acute POE after phacoemulsification decreased from 0.145% to 0.053% during this 10-year period; the unadjusted incidence rate ratio (IRR) (95% confidence interval) was 0.37 (0.32-0.42; P < 0.001). In multivariate analysis, intracameral antibiotic injection was associated with a lower risk of acute POE 0.53 (0.50-0.57; P < 0.001), whereas intraoperative posterior capsule rupture, combined surgery, and gender (male) were associated with a higher risk of acute POE: 5.24 (4.11-6.68), 1.77 (1.53-2.05), and 1.48 (1.40-1.56) (P < 0.001), respectively.
  
  
  
  Access to a national database allowed us to observe a decrease in acute POE after phacoemulsification cataract surgery from 2005 to 2014. Within the same period, the use of intracameral antibiotics during the surgical procedures increased.
authors.affiliation: Department of Ophthalmology, University Hospital, Dijon, France; Eye and Nutrition Research Group, Bourgogne Franche-Comté University, Dijon, France. Electronic address: catherine.creuzot-garcher@chu-dijon.fr.
authors.forename: Catherine
authors.initials: C
authors.lastname: Creuzot-Garcher
authors.affiliation: University Hospital, Dijon, France; Biostatistics and Bioinformatics (DIM), Dijon, France; Bourgogne Franche-Comté University, Dijon, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Benzenine
authors.affiliation: University Hospital, Dijon, France; Biostatistics and Bioinformatics (DIM), Dijon, France; Bourgogne Franche-Comté University, Dijon, France; INSERM, CIC 1432, Dijon, France; Dijon University Hospital, Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Dijon, France; INSERM UMR 1181 Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), Bourgogne Franche-Comté University, Dijon, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Mariet
authors.affiliation: Department of Ophthalmology, University Hospital, Dijon, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: de Lazzer
authors.affiliation: Department of Ophthalmology, University Hospital, Grenoble, France; Joseph Fourier University, Grenoble 1, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Chiquet
authors.affiliation: Department of Ophthalmology, University Hospital, Dijon, France; Eye and Nutrition Research Group, Bourgogne Franche-Comté University, Dijon, France.
authors.forename: Alain M
authors.initials: AM
authors.lastname: Bron
authors.affiliation: University Hospital, Dijon, France; Biostatistics and Bioinformatics (DIM), Dijon, France; Bourgogne Franche-Comté University, Dijon, France; INSERM, CIC 1432, Dijon, France; Dijon University Hospital, Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Dijon, France; INSERM UMR 1181 Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), Bourgogne Franche-Comté University, Dijon, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Quantin
mesh_terms: D000208:Acute Disease; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002444:Cefuroxime / Q000627:therapeutic use; D009877:Endophthalmitis / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D005144:F Factor; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018918:Phacoemulsification / Q000009:adverse effects*; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D002444:Cefuroxime