title: Assessment of brachial artery reactivity, carotid intima-media thickness, and adhesion molecules in pediatric solid tumor patients treated with anthracyclines.
abstract: The aim of this study was to determine subclinical atherosclerosis and endothelial functional disturbance with measurement of carotid intima-media thickness (IMT), brachial artery reactivity (BAR), and levels of serum adhesion molecules in children with solid tumors who were treated with anthracyclines and are actually in complete remission. Fifty patients who were in remission and 30 healthy children were included in the study. Mean ages of patient and control groups were 13.5 ± 4.7 years (range: 3-23 years) and 12.00 ± 4.3 years (range: 4-21 years), respectively. The patients were divided into 3 groups according to cumulative doxorubicin dose: Group 1, ≤100 mg/m(2); Group 2, 101-299 mg/m(2); Group 3, ≥300 mg/m(2). The BAR and carotid IMT were measured in order to determine the endothelial function. The serum adhesion molecule levels in our patients and controls were also measured. The BAR of the patients with cumulative anthracycline dose ≥300 mg/m(2) was significantly lower than the patients with cumulative anthracycline dose ≤100 mg/m(2) and healthy controls (P =.005 and P =.003, respectively). Also, there was a negative correlation between brachial artery reactivity and increasing cumulative anthracycline dose (r = -.287, P =.044). We also found significant difference between the mean carotid IMT of the patients and the healthy children (P =.041). No statistically significant difference was detected between the serum levels of sICAM-1 (soluble intercellular adhesion molecule-1), sVCAM-1 (soluble vascular cell adhesion molecule-1), sE-selectin of the patients and controls. The use of anthracyclines in pediatric patients with cancer could result in increase of the carotid IMT and endothelial dysfunction.
authors.affiliation: a Division of Pediatric Hematology and Oncology, Department of Pediatrics, Gazi University Medical School , Ankara , Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Okur
authors.affiliation: a Division of Pediatric Hematology and Oncology, Department of Pediatrics, Gazi University Medical School , Ankara , Turkey.
authors.forename: Ceyda
authors.initials: C
authors.lastname: Karadeniz
authors.affiliation: b Department of Radiology , Gazi University Medical School , Ankara , Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Özhan Oktar
authors.affiliation: a Division of Pediatric Hematology and Oncology, Department of Pediatrics, Gazi University Medical School , Ankara , Turkey.
authors.forename: Faruk Güçlü
authors.initials: FG
authors.lastname: Pınarlı
authors.affiliation: c Department of Immunology , Gazi University Medical School , Ankara , Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Aral
authors.affiliation: a Division of Pediatric Hematology and Oncology, Department of Pediatrics, Gazi University Medical School , Ankara , Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Oğuz
mesh_terms: D000293:Adolescent; D000328:Adult; D018943:Anthracyclines / Q000627:therapeutic use*; D001916:Brachial Artery / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D015815:Cell Adhesion Molecules / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D019040:E-Selectin / Q000097:blood; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D018943:Anthracyclines; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1
keywords: Adhesion molecules; anthracycline; brachial artery reactivity; carotid childhood cancer; intima-media thickness