title: The Hippo pathway member YAP enhances human neural crest cell fate and migration.
abstract: The Hippo/YAP pathway serves as a major integrator of cell surface-mediated signals and regulates key processes during development and tumorigenesis. The neural crest is an embryonic tissue known to respond to multiple environmental cues in order to acquire appropriate cell fate and migration properties. Using multiple in vitro models of human neural development (pluripotent stem cell-derived neural stem cells; LUHMES, NTERA2 and SH-SY5Y cell lines), we investigated the role of Hippo/YAP signaling in neural differentiation and neural crest development. We report that the activity of YAP promotes an early neural crest phenotype and migration, and provide the first evidence for an interaction between Hippo/YAP and retinoic acid signaling in this system.
authors.affiliation: Emmy Noether-Group for Stem Cell Biology, Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Hindley
authors.affiliation: Emmy Noether-Group for Stem Cell Biology, Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg.|Spemann Graduate School of Biology and Medicine and Faculty of Biology, University of Freiburg, Freiburg, Germany.
authors.forename: Alexandra Larisa
authors.initials: AL
authors.lastname: Condurat
authors.affiliation: Emmy Noether-Group for Stem Cell Biology, Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg.|Spemann Graduate School of Biology and Medicine and Faculty of Biology, University of Freiburg, Freiburg, Germany.
authors.forename: Vishal
authors.initials: V
authors.lastname: Menon
authors.affiliation: Emmy Noether-Group for Stem Cell Biology, Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg.|Spemann Graduate School of Biology and Medicine and Faculty of Biology, University of Freiburg, Freiburg, Germany.
authors.forename: Ria
authors.initials: R
authors.lastname: Thomas
authors.affiliation: Emmy Noether-Group for Stem Cell Biology, Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Azmitia
authors.affiliation: Emmy Noether-Group for Stem Cell Biology, Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Davis
authors.affiliation: Emmy Noether-Group for Stem Cell Biology, Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg.|Center for Biological Signaling Studies (BIOSS), University of Freiburg.
authors.forename: Jan
authors.initials: J
authors.lastname: Pruszak
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D015703:Antigens, CD / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D009432:Neural Crest / Q000166:cytology*; D058953:Neural Stem Cells / Q000502:physiology*; D055495:Neurogenesis; D010750:Phosphoproteins / Q000502:physiology*; D015398:Signal Transduction; D014157:Transcription Factors; D014212:Tretinoin / Q000494:pharmacology; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015703:Antigens, CD; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; D014212:Tretinoin