title: Fecal microbiota transplantation in children: a brief review.
abstract: There has been a growing interest in fecal microbiota transplantation (FMT) over recent years, in part due to the increasing prevalence of Clostridium difficile infection (CDI) and expanding association of intestinal dysbiosis with a wide range of human diseases. Many adult studies have shown that FMT is an effective treatment for recurrent CDI and may possibly have applications in other illnesses such as inflammatory bowel disease (IBD); however, there is a paucity of data available in children who may differ from adults for many reasons including having a dynamic developing microbiome compared to adults who have a relatively stable microbiome. Here, we review published studies looking at FMT in children, for CDI and IBD, and discuss special considerations needed when conducting FMT in children.
authors.affiliation: Department of Pediatrics, Inova Children's Hospital, Fairfax, Virginia.|Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.|Department of Pediatrics, Pediatric Specialists of Virginia, Fairfax, Virginia.|Inova Translational Medicine Institute, Inova Health System, Fairfax, Virginia.
authors.forename: Suchitra K
authors.initials: SK
authors.lastname: Hourigan
authors.affiliation: Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Maria
authors.initials: M
authors.lastname: Oliva-Hemker
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D003015:Clostridium Infections / Q000628:therapy*; D064806:Dysbiosis; D000069467:Fecal Microbiota Transplantation / Q000379:methods*; D005243:Feces / Q000382:microbiology*; D006801:Humans; D007223:Infant; D015212:Inflammatory Bowel Diseases / Q000628:therapy*; D007422:Intestines; D064307:Microbiota; D010372:Pediatrics / Q000379:methods; D012008:Recurrence; D012307:Risk Factors; D016896:Treatment Outcome