title: Reverse Engineering Human Pathophysiology with Organs-on-Chips.
abstract: While studies of cultured cells have led to new insights into biological control, greater understanding of human pathophysiology requires the development of experimental systems that permit analysis of intercellular communications and tissue-tissue interactions in a more relevant organ context. Human organs-on-chips offer a potentially powerful new approach to confront this long-standing problem.
authors.affiliation: Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Vascular Biology Program, Departments of Pathology & Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, USA. Electronic address: don.ingber@wyss.harvard.edu.
authors.forename: Donald E
authors.initials: DE
authors.lastname: Ingber
mesh_terms: D001812:Blood-Brain Barrier; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D009369:Neoplasms / Q000503:physiopathology; D009924:Organ Culture Techniques; D023822:Tissue Engineering / Q000379:methods*