title: Genetic Targeting in Cerebellar Purkinje Cells: an Update.
abstract: Since the last review paper published in Cerebellum in 2002 [1], there has been a substantial increase in the number of experiments utilizing transgenic manipulations in murine cerebellar Purkinje cells. Most of these approaches were made possible with the use of the Cre/loxP methodology and pcp2/L7 based Cre recombinase expressing transgenic mouse strains. This review aims to summarize all studies which used Purkinje cell specific transgenesis since the first use of mouse strain with Purkinje cell specific Cre expression in 2002.
authors.affiliation: Center for Experimental Medicine, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.|Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Sługocka
authors.affiliation: Department of Pharmacology & Physiology, The George Washington University, 2300 Eye St., NW, Washington, DC, 20037, USA.
authors.forename: Jan
authors.initials: J
authors.lastname: Wiaderkiewicz
authors.affiliation: Center for Experimental Medicine, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland. jbarski@sum.edu.pl.|Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland. jbarski@sum.edu.pl.
authors.forename: Jaroslaw J
authors.initials: JJ
authors.lastname: Barski
mesh_terms: D000818:Animals; D008822:Mice, Transgenic; D023421:Models, Animal; D011689:Purkinje Cells / Q000378:metabolism*
keywords: Cerebellum; Gene targeting; Mouse; Purkinje cells