title: A novel norovirus GII.17 lineage contributed to adult gastroenteritis in Shanghai, China, during the winter of 2014–2015.
abstract: Norovirus (NoV) is now recognized as a leading cause of nonbacterial acute gastroenteritis; however, the NoV GII.17 genotype has rarely been reported as the predominant genotype in clinical diarrhea cases. During the winter of 2014–2015, the GII.17 genotype, together with the NoV GII.4 genotype, dominated in sporadic adult patients with gastroenteritis in Shanghai. Phylogenetic analysis based on full-length VP1 amino acid sequences showed that the GII.17 strains that emerged in Shanghai have close evolutionary relationships with strains recently collected in the Hong Kong area, Guangdong province of China, and Japan during the same period. This cluster in the phylogenetic tree may represent a novel NoV GII.17 lineage recently circulating in East Asia. Pairwise distances between clusters also revealed the evolution of the NoV GII.17 genotype in previous decades. Our study emphasizes the importance of combined surveillance of NoV-associated infections.
authors.forename: Haili
authors.initials: H
authors.lastname: Chen
authors.forename: Fangxing
authors.initials: F
authors.lastname: Qian
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.forename: Martin
authors.initials: M
authors.lastname: Chan
authors.forename: Zhen
authors.initials: Z
authors.lastname: Shen
authors.forename: Shubei
authors.initials: S
authors.lastname: Zai
authors.forename: Menglin
authors.initials: M
authors.lastname: Shan
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Cai
authors.forename: Wanju
authors.initials: W
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Yuan
authors.forename: Zhaoqin
authors.initials: Z
authors.lastname: Zhu
authors.forename: Yunwen
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D017250:Caliciviridae Infections / Q000453:epidemiology* / Q000821:virology*; D002648:Child; D002681:China / Q000453:epidemiology; D062665:Epidemiological Monitoring; D005202:Asia, Eastern / Q000453:epidemiology; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000821:virology*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D029322:Norovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D012621:Seasons; D017422:Sequence Analysis, DNA; D015678:Viral Structural Proteins / Q000235:genetics; D055815:Young Adult
chemical_list: D012367:RNA, Viral; D015678:Viral Structural Proteins