title: ExRNA in Biofluids as Biomarkers for Brain Tumors.
abstract: Patients with high-grade gliomas and glioblastomas (GBMs) have poor survival despite optimal surgical and drug therapy. Minimally invasive diagnostic biomarkers would enable early diagnosis and tumor-specific treatments for 'personalized targeted' therapy, and would create the basis for response tracking in patients with GBM. Extracellular vesicles (EVs) isolated from cerebrospinal fluid and blood contain glioma-specific molecules, including tumor-derived EV RNAs that are detectable in small copy numbers in these biofluids. EV RNA mutations or expression changes are also detectable, the analysis of which gives rise to 'liquid biopsy' tumor profiling.
authors.affiliation: Department of Neurosurgery, University of California - San Diego, 3855 Health Science Drive #0987, La Jolla, San Diego, CA, 92093-0987, USA. rrennert@ucsd.edu.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Rennert
authors.affiliation: Department of Neurosurgery, University of California - San Diego, 3855 Health Science Drive #0987, La Jolla, San Diego, CA, 92093-0987, USA.
authors.forename: Fred H
authors.initials: FH
authors.lastname: Hochberg
authors.affiliation: Department of Neurosurgery, University of California - San Diego, 3855 Health Science Drive #0987, La Jolla, San Diego, CA, 92093-0987, USA.
authors.forename: Bob S
authors.initials: BS
authors.lastname: Carter
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D000067128:Extracellular Vesicles / Q000378:metabolism*; D006801:Humans
chemical_list: D014408:Biomarkers, Tumor
keywords: Extracellular vesicle; Glioblastoma; Glioma; RNA