title: Increased Local Spontaneous Neural Activity in the Left Precuneus Specific to Auditory Verbal Hallucinations of Schizophrenia.
abstract: BACKGROUND
  Auditory verbal hallucinations (AVHs) of schizophrenia have been associated with structural and functional alterations of some brain regions. However, the brain regional homogeneity (ReHo) alterations specific to AVHs of schizophrenia remain unclear. In the current study, we aimed to investigate ReHo alterations specific to schizophrenic AVHs.
  
  
  METHODS
  Thirty-five schizophrenic patients with AVH, 41 schizophrenic patients without AVHs, and fifty healthy subjects underwent resting-state functional magnetic resonance imaging. ReHo differences across the three groups were tested using a voxel-wise analysis.
  
  
  RESULTS
  Compared with the healthy control group, the two schizophrenia groups showed significantly increased ReHo in the right caudate and inferior temporal gyrus and decreased ReHo in the bilateral postcentral gyrus and thalamus and the right inferior occipital gyrus (false discovery rate corrected, P < 0.05). More importantly, the AVH group exhibited significantly increased ReHo in the left precuneus compared with the non-AVH group. However, using correlation analysis, we did not find any correlation between the auditory hallucination rating scale score and the ReHo of brain regions.
  
  
  CONCLUSIONS
  Our results suggest that increased ReHo in the left precuneus may be a pathological feature exclusive to schizophrenic AVHs.
authors.forename: Chuan-Jun
authors.initials: CJ
authors.lastname: Zhuo
authors.forename: Jia-Jia
authors.initials: JJ
authors.lastname: Zhu
authors.forename: Chun-Li
authors.initials: CL
authors.lastname: Wang
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Qin
mesh_terms: D000328:Adult; D005260:Female; D006212:Hallucinations / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010296:Parietal Lobe / Q000503:physiopathology*; D012559:Schizophrenia / Q000473:pathology / Q000503:physiopathology*