title: Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I(131) during Adolescence and Young Adulthood.
abstract: Introduction. Differentiated thyroid cancer (DTC) is rare and confers good prognosis. Long-term health related quality of life (HRQoL) and pregnancy outcomes are not well known in subjects treated during adolescence and young adulthood. Methods. Cross-sectional analysis of HRQoL and global self-esteem, using SF-36 and ISP-25 surveys, and of pregnancy outcomes in female survivors of DTC treated by total thyroidectomy and I(131) before age of 25 years. Results. Forty-five of 61 patients (74%) responded to the survey. Cumulative I(131) activity was ≤3.85 GBq in 18 subjects and >3.85 GBq in 27 subjects. Mean time from diagnosis was 7.6 ± 5.2 years for the group ≤ 3.85 GBq versus 16.9 ± 11.6 years for the group > 3.85 GBq (P < 0.05). No significant alteration in long-term HRQoL and global self-esteem was observed. Thirty pregnancies after I(131) were noted in patients from the group > 3.85 GBq and 10 in patients from the group ≤ 3.85 GBq. Frequency of miscarriages was of 17% (group > 3.85 GBq) and 10% (group ≤ 3.85 GBq) with 9 and 24 live births, respectively. No congenital malformations or first year mortality was noted. Conclusion. Long-term HRQoL, global self-esteem, and pregnancy outcomes are not affected in young female survivors of DTC.
authors.affiliation: Department of Endocrinology, University Hospital Center of Nancy, 54000 Nancy, France.
authors.forename: Melanie
authors.initials: M
authors.lastname: Metallo
authors.affiliation: Department of Endocrinology, University Hospital Center of Nancy, 54000 Nancy, France.
authors.forename: Lelia
authors.initials: L
authors.lastname: Groza
authors.affiliation: Department of General and Endocrine Surgery, University Hospital Center of Nancy, 54000 Nancy, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Brunaud
authors.affiliation: Department of Endocrinology, University Hospital Center of Nancy, 54000 Nancy, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Klein
authors.affiliation: Department of Endocrinology, University Hospital Center of Nancy, 54000 Nancy, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Weryha
authors.affiliation: Department of Endocrinology, University Hospital Center of Nancy, 54000 Nancy, France; Department of Endocrinology, University Hospital Center of Poitiers, 86000 Poitiers, France.
authors.forename: Eva
authors.initials: E
authors.lastname: Feigerlova