title: Chromosomes and clinical anatomy.
abstract: Chromosome abnormalities may cast light on the nature of mechanisms whereby normal anatomy evolves, and abnormal anatomy arises. Correlating genotype to phenotype is an exercise in which the geneticist and the anatomist can collaborate. The increasing power of the new genetic methodologies is enabling an increasing precision in the delineation of chromosome imbalances, even to the nucleotide level; but the classical skills of careful observation and recording remain as crucial as they always have been. Clin. Anat. 29:540-546, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Clinical Genetics Group, Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
authors.forename: Robert James McKinlay
authors.initials: RJ
authors.lastname: Gardner
mesh_terms: D025063:Chromosome Disorders / Q000235:genetics*; D002875:Chromosomes; D004622:Embryo, Mammalian / Q000002:abnormalities*; D005333:Fetus / Q000002:abnormalities; D006801:Humans; D007621:Karyotyping; D010641:Phenotype; D024182:Uniparental Disomy
keywords: anatomy; chromosomes; morphogenesis