title: Generation of iPSC line epiHUVEC from human umbilical vein endothelial cells.
abstract: Human umbilical vein endothelial cells (HUVECs) were used to generate the iPSC line epiHUVEC employing a combination of three episomal-based plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and KLF4. Pluripotency was confirmed both in vivo and in vitro. The transcriptome profile of epiHUVEC and the human embryonic stem cell line - H1 have a Pearson correlation of 0.899.
authors.affiliation: Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany; Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany; Institute of Biology, Humboldt University, 10099 Berlin, Germany.
authors.forename: Peggy
authors.initials: P
authors.lastname: Matz
authors.affiliation: Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany; Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
authors.forename: James
authors.initials: J
authors.lastname: Adjaye
mesh_terms: D002454:Cell Differentiation; D002460:Cell Line; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism*; D000090062:Kruppel-Like Factor 4