title: 1,2-Thiazines: One-Pot Syntheses Utilizing Mono and Diaza Analogs of Sulfones.
abstract: A one-pot Michael addition/cyclization/condensation reaction sequence for the regioselective synthesis of 1,2-thiazines, starting from propargyl ketones and NH-sulfoximines or NH-sulfondiimines, has been developed. Under mild and operationally simple reaction conditions previously unprecedented 1,2-thiazine 1-imide and 1-oxide derivatives are formed in good to excellent yields. The products represent heterocyclic building blocks, readily modifiable by a regioselective C-H bond functionalization, classical cross-coupling reactions, and deprotection.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany), Fax.
authors.forename: Rebekka Anna
authors.initials: RA
authors.lastname: Bohmann
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany), Fax.|Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka, 565-0871, Japan.
authors.forename: Yuto
authors.initials: Y
authors.lastname: Unoh
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka, 565-0871, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miura
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany), Fax. Carsten.Bolm@oc.RWTH-Aachen.de.
authors.forename: Carsten
authors.initials: C
authors.lastname: Bolm
keywords: Michael addition; cyclization; heterocycles; sulfoximines; thiazines