title: Humoral Immune Response against Neural Antigens and Its Effects on Cognition in Lung Cancer Patients.
abstract: Cognitive impairment develops as a clinical manifestation of immune-mediated indirect effects of malignancy in lung cancer patients. This study aimed to evaluate the effects of humoral immune response on cognition in lung cancer patients. Fifty-one lung cancer patients were subjected to neurological examination: Mini Mental State Examination (MMSE), Trail Making Test (TMT), and Hamilton scale. The Psychology Experiment Building Language software was used for the evaluation of digit span, simple reaction time (SRT), and choice reaction time (CRT) tests. Serum samples were tested for the presence of onconeuronal antibodies and antineural antibodies. The results demonstrate that autoantibodies were found in 31 % patients. MMSE scores were lower (26.7 ± 2.7) in seropositive patients than in seronegative subjects (28.7 ± 1.2; p = 0.013). Executive functions were also influenced by the presence of autoantibodies. The humoral immune response in lung cancer patients affected both SRT and CRT. We conclude that the humoral immune response in lung cancer patients is associated with cognitive impairment. Cognitive impairment is associated with both specific reactions against onconeuronal or antineural antigens and non-organ specific reactions against nucleosome antigens.
authors.affiliation: Department of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-355, Poznan, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Rybacka-Mossakowska
authors.affiliation: Department of Oncology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Ramlau
authors.affiliation: Cancer Center, Poznan, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Gazdulska
authors.affiliation: Lung Diseases Center, Poznan, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Gołda-Gocka
authors.affiliation: Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Kozubski
authors.affiliation: Department of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-355, Poznan, Poland. swami622@gmail.com.|Neuroimmunological Unit, The Mossakowski Medical Research Center of the Polish Academy of Sciences, Poznan, Poland. swami622@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Michalak
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000523:psychology; D000974:Antibodies, Antinuclear / Q000097:blood*; D000951:Antigens, Neoplasm / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D014408:Biomarkers, Tumor / Q000097:blood; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000473:pathology / Q000523:psychology; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology / Q000523:psychology; D003072:Cognition Disorders / Q000097:blood / Q000209:etiology* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009483:Neuropsychological Tests; D011379:Prognosis; D011446:Prospective Studies; D011597:Psychomotor Performance; D055752:Small Cell Lung Carcinoma / Q000150:complications / Q000473:pathology / Q000523:psychology; D014145:Trail Making Test
chemical_list: D000974:Antibodies, Antinuclear; D000951:Antigens, Neoplasm; D001323:Autoantibodies; D014408:Biomarkers, Tumor; D009419:Nerve Tissue Proteins
keywords: Antineural antibodies; Executive functions; Memory; Onconeuronal antibodies; Pulmonary neoplasms