title: A G4·K(+) hydrogel that self-destructs.
abstract: A G4-quartet based hydrogel formed by self-assembly of borate esters of 5'-deoxy-5'-iodoguanosine (5'-IG 2) undergoes in situ cyclization to give 5'-deoxy-N3,5'-cycloguanosine (5'-cG 3). Formation of 5'-cG 3 causes self-destruction of the gel. This intramolecular cyclization can be used to release nucleoside analogs that have been pre-incorporated into the gel network.
authors.affiliation: Department of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742, USA. jdavis@umd.edu.
authors.forename: Taylor N
authors.initials: TN
authors.lastname: Plank
authors.forename: Jeffery T
authors.initials: JT
authors.lastname: Davis
mesh_terms: D003500:Cyclization; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry*; D008968:Molecular Conformation
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate