title: Three new cembranoids from the Bornean soft coral Nephthea sp.
abstract: Three new cembranoid diterpenes, 10-hydroxy-nephthenol acetate (1), 7,8-epoxy-10-hydroxy-nephthenol acetate (2), and 6-acetoxy-7,8-epoxy-10-hydroxy-nephthenol acetate (3), along with a known compound, 6-acetoxy-7,8-epoxy-nephthenol acetate (4), were isolated from the Bornean soft coral Nephthea sp. Antibacterial and anticancer activities were exhibited by compounds 1 and 2 against Staphylococcus aureus (ATCC 6538)/Escherichia coli (ATCC 13311) and Hela/MCF-7, respectively.
authors.affiliation: a Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation , Universiti of Malaysia Sabah , Kota Kinabalu , Malaysia.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ishii
authors.affiliation: a Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation , Universiti of Malaysia Sabah , Kota Kinabalu , Malaysia.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kamada
authors.affiliation: a Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation , Universiti of Malaysia Sabah , Kota Kinabalu , Malaysia.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Vairappan
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: C000613399:10-hydroxy-nephthenol acetate; C000613401:6-acetoxy-7,8-epoxy-10-hydroxy-nephthenol acetate; C000613400:7,8-epoxy-10-hydroxy-nephthenol acetate; D000900:Anti-Bacterial Agents; D004224:Diterpenes
keywords: Bornean soft coral; Cembranoid; Nephthea sp.; Nephtheidae