title: Clinicopathological Factors Related to the Prognosis of Metastatic Breast Cancer Patients after Development of Brain Metastasis.
abstract: BACKGROUND
  The prognosis of breast cancer patients with brain metastasis (BM) is extremely poor, and the survival after development of BM is very short. We aimed to investigate clinicopathological factors related to significant effects on the prognosis after BM development.
  
  
  METHODS
  This is a retrospective study of 75 early breast cancer patients who received the standard of care and subsequently developed BM.
  
  
  RESULTS
  Breast cancer subtype was one of the significant predictors for prognosis after BM diagnosis. Luminal HER2 patients had the most favorable prognosis after BM diagnosis (p = 0.011). Favorable performance status (PS) at BM diagnosis (p < 0.001) and a single metastatic brain tumor (p = 0.032) were significantly associated with good prognosis after BM diagnosis. Metastatic time courses of the patients was found not to be significantly associated with survival after BM diagnosis. Univariate and multivariate analysis indicated that luminal HER2 cancer, favorable PS at BM diagnosis, and a single metastatic brain tumor were the independent prognostic factors for survival after BM development, making a decisive influence on local or systemic control.
  
  
  CONCLUSIONS
  Appropriate treatments for tumor subtypes and to improve the general condition of patients would result in improved outcomes for the patients with BM.
authors.affiliation: Department of Surgery, Sakai City Medical Center, Osaka, Japan; Department of Surgery and Breast Oncology, Osaka National Hospital, Osaka, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Yamamura
authors.affiliation: Department of Surgery and Breast Oncology, Osaka National Hospital, Osaka, Japan.
authors.forename: Norikazu
authors.initials: N
authors.lastname: Masuda
authors.affiliation: Department of Surgery and Breast Oncology, Osaka National Hospital, Osaka, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yasojima
authors.affiliation: Department of Surgery and Breast Oncology, Osaka National Hospital, Osaka, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Mizutani
authors.affiliation: Radiology, Osaka National Hospital, Osaka, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Kuriyama
authors.affiliation: Department of Surgery and Breast Oncology, Osaka National Hospital, Osaka, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Nakamori
authors.affiliation: Department of Surgery and Breast Oncology, Osaka National Hospital, Osaka, Japan.
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Sekimoto
authors.affiliation: Pathology, Osaka National Hospital, Osaka, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Mano
authors.affiliation: Radiation Oncology, Osaka National Hospital, Osaka, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Tanaka
authors.affiliation: Neurosurgery, Osaka National Hospital, Osaka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nonaka
keywords: Brain metastases; Breast cancer; Prognostic factor; Survival