title: Immunohistochemical Study of TGF-β1 in Oral Leukoplakia and Oral Squamous Cell Carcinoma: Correlations Between Clinicopathologic Factors and Overall Survival.
abstract: The aim of the present study was to analyze transforming growth factor β1 (TGF-β1) expression in cases of leukoplakia and oral squamous cell carcinoma (OSCC) and to correlate these expression profiles with proliferative labeling index, clinicopathologic factors, and clinical outcome. Clinical data for 24 cases of leukoplakia and 87 cases of OSCC were retrieved from medical records. OSCC tissues were included into tissue microarray blocks and sections of normal mucosa, leukoplakia, and OSCC tissue microarray's were prepared on slides. Immunohistochemistry was used to detect expression of TGF-β1 and Ki67. The expression of TGF-β1 and Ki67 were significantly increased from normal mucosa, through leukoplakia to OSCC. High expression of TGF-β1 correlated with an increase in proliferative labeling index. No association between TGF-β1 expression and the clinicopathologic factors examined was observed. Expression of TGF-β1 also did not associate with clinical outcome in either of groups. Our results suggest that changes in TGF-β1 are associated with the progression of oral carcinogenesis.
authors.affiliation: *Department of Oral Pathology, School of Dentistry, Universidade Federal do rio Grande do Sul ‡Department of Pathology, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul †Department of Oral Pathology, Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia §Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Vivian P
authors.initials: VP
authors.lastname: Wagner
authors.forename: Paula R
authors.initials: PR
authors.lastname: Cardoso
authors.forename: Jean N
authors.initials: JN
authors.lastname: Dos Santos
authors.forename: Luise
authors.initials: L
authors.lastname: Meurer
authors.forename: Pablo A
authors.initials: PA
authors.lastname: Vargas
authors.forename: Felipe P
authors.initials: FP
authors.lastname: Fonseca
authors.forename: Vinicius C
authors.initials: VC
authors.lastname: Carrard
authors.forename: Manoela D
authors.initials: MD
authors.lastname: Martins
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007972:Leukoplakia, Oral / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D016019:Survival Analysis; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
chemical_list: D053773:Transforming Growth Factor beta1