title: Managing patients at genetic risk of breast cancer.
abstract: Hereditary syndromes that increase the risk of breast cancer are not common, but it is critical to recognize and manage them appropriately. This paper reviews the management of patients with the most common hereditary breast cancer syndromes, ie, hereditary breast and ovarian cancer syndrome, hereditary diffuse gastric cancer, Cowden syndrome (PTEN hamartoma tumor syndrome), Peutz-Jeghers syndrome, and Li-Fraumeni syndrome.
authors.affiliation: Director, Medical Breast Services, Department of Breast Services, Cleveland Clinic, Cleveland, OH, USA. E-mail: pedersh@ccf.org.|Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA.|Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.|Case Comprehensive Cancer Center representative to NCCN Breast Cancer Risk Reduction Committee.
authors.forename: Holly J
authors.initials: HJ
authors.lastname: Pederson
authors.affiliation: Mount Carmel Medical Group, Columbus, OH, USA.
authors.forename: Shilpa A
authors.initials: SA
authors.lastname: Padia
authors.affiliation: Allegheny Health Network, Pittsburgh, PA, USA.
authors.forename: Maureen
authors.initials: M
authors.lastname: May
authors.affiliation: Director, Department of Breast Services, Cleveland Clinic, Cleveland, OH, USA.|Director, Surgical Oncology, Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA.|Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Grobmyer
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D003131:Combined Modality Therapy; D019468:Disease Management; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods*; D014943:Global Health; D006801:Humans; D015994:Incidence; D018570:Risk Assessment