title: Problem-based learning discussion: Medical treatment of pediatric chronic rhinosinusitis.
abstract: This problem-based learning case focused on the approach to evaluation and management of a 5-year old girl who was "always sick" with sinus infections. The discussion unfolds in a "real life" scenario, i.e., based on information available to the clinician initially and after the acquisition of laboratory data, and, ultimately, after sinus surgery. Emphasis is placed on the differential diagnosis of the patient's symptoms, discussion of the initial management strategy for chronic rhinosinusitis (CRS), evolution from acute rhinosinusitis to CRS, the prevalence of and differential diagnosis of nasal polyps in children, treatment considerations specific for CRS with nasal polyps, the significance of Pseudomonas aeruginosa sinus infection, the significance of an abnormal sweat chloride test in a young child with nasal polyposis, special considerations in children with CRS who have cystic fibrosis, treatment considerations after endoscopic sinus surgery, and, finally, prognostic factors that impact the outcomes of endoscopic sinus surgery. This problem-based learning case highlights many facets of managing refractory CRS in children.
authors.affiliation: Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Hamilos
mesh_terms: D002675:Child, Preschool; D002712:Chlorides / Q000032:analysis; D002908:Chronic Disease; D003937:Diagnosis, Differential; D019468:Disease Management; D005260:Female; D006801:Humans; D009298:Nasal Polyps / Q000175:diagnosis*; D018794:Problem-Based Learning; D011552:Pseudomonas Infections / Q000175:diagnosis*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D012220:Rhinitis / Q000175:diagnosis*; D012852:Sinusitis / Q000175:diagnosis*; D013542:Sweat / Q000737:chemistry
chemical_list: D002712:Chlorides