title: Evaluation of Plasma Isoprostane in Patients with Oral Lichen Planus.
abstract: Lichen planus is a chronic inﬂammatory disease. Free radicals and reactive oxygen species play important roles in pathogenesis of oral lichen planus (OLP). Isoprostanes show oxidative stress and are formed by free-radical mediated lipid peroxidation of arachidonic acid and cell membrane phospholipids.
  
  
  OBJECTIVE
  This study was conducted to evaluate the plasma level of 8-isoprostane in patients suffering from erosive and non-erosive forms of OLP.
  
  
  METHODS
  In this case-control study, 31 patients with OLP and 30 control subjects were enrolled. Plasma samples were obtained and the level of 8-isoprostane was measured with Sandwich enzyme-linked immunosorbent assay (ELISA) in both groups. The data were analyzed by using two-sample t-test, chi-square and ANOVA tests.
  
  
  RESULTS
  The results showed significant increase in the plasma level of 8-isoprostane in OLP group compared with the control group. The results of independent t-test revealed no significant correlation between the plasma level of isoprostane and sex, smoking, or previous treatment.
  
  
  CONCLUSIONS
  Based on the findings of this study, oxidative stress was increased in patients with OLP, reflected by higher concentrations of 8-isoprostane in plasma.
authors.affiliation: Oral and Maxillofacial Diseases Research Center, Dept. of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Amirchaghmaghi
authors.affiliation: Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of MedicalSciences, Mashhad, Iran.
authors.forename: Seyed Isaac
authors.initials: SI
authors.lastname: Hashemy
authors.affiliation: Undergraduate Student, Faculty of Dentistry, Mashhad University of MedicalSciences, Mashhad, Iran.
authors.forename: Banafsheh
authors.initials: B
authors.lastname: Alirezaei
authors.affiliation: Undergraduate Student, Faculty of Dentistry, Mashhad University of MedicalSciences, Mashhad, Iran.
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Jahed Keyhani
authors.affiliation: Undergraduate Student, Faculty of Dentistry, Mashhad University of MedicalSciences, Mashhad, Iran.
authors.forename: Sanaz
authors.initials: S
authors.lastname: Kargozar
authors.affiliation: Undergraduate Student, Faculty of Dentistry, Mashhad University of MedicalSciences, Mashhad, Iran.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Vasigh
authors.affiliation: Undergraduate Student, Faculty of Dentistry, Mashhad University of MedicalSciences, Mashhad, Iran.
authors.forename: Shideh
authors.initials: S
authors.lastname: Gharaei
authors.affiliation: Oral and Maxillofacial Diseases Research Center, Dept. of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Atessa
authors.initials: A
authors.lastname: Pakfetrat
keywords: Isoprostane; Oral Lichen Planus; Oxidative Stress