title: Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein.
abstract: We report the crystal structure of a novel 60-subunit dodecahedral cage that results from self-assembly of a re-engineered version of a natural protein (PduA) from the Pdu microcompartment shell. Biophysical data illustrate the dependence of assembly on solution conditions, opening up new applications in microcompartment studies and nanotechnology.
authors.affiliation: UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA. yeates@mbi.ucla.edu.
authors.forename: J
authors.initials: J
authors.lastname: Jorda
authors.forename: D J
authors.initials: DJ
authors.lastname: Leibly
authors.forename: M C
authors.initials: MC
authors.lastname: Thompson
authors.forename: T O
authors.initials: TO
authors.lastname: Yeates
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry*; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D015202:Protein Engineering; D012486:Salmonella typhimurium / Q000737:chemistry*
chemical_list: D001426:Bacterial Proteins