title: Partial validation of a French version of the ADHD-rating scale IV on a French population of children with ADHD and epilepsy. Factorial structure, reliability, and responsiveness.
abstract: Attention deficit hyperactivity disorder (ADHD) is a well-known comorbidity in children with epilepsy. In English-speaking countries, the scores of the original ADHD-rating scale IV are currently used as main outcomes in various clinical trials in children with epilepsy. In French-speaking countries, several French versions are in use though none has been fully validated yet. We sought here for a partial validation of a French version of the ADHD-RS IV regarding construct validity, internal consistency (i.e., scale reliability), item reliability, and responsiveness in a group of French children with ADHD and epilepsy.
  
  
  
  The study involved 167 children aged 6-15years in 10 French neuropediatric units. The factorial structure and item reliability were assessed with a confirmatory factorial analysis for ordered categorical variables. The dimensions' internal consistency was assessed with Guttman's lambda 6 coefficient. The responsiveness was assessed by the change in score under methylphenidate and in comparison with a control group.
  
  
  
  The results confirmed the original two-dimensional factorial structure (inattention, hyperactivity/impulsivity) and showed a satisfactory reliability of most items, a good dimension internal consistency, and a good responsiveness of the total score and the two subscores.
  
  
  
  The studied French version of the ADHD-RS IV is thus validated regarding construct validity, reliability, and responsiveness. It can now be used in French-speaking countries in clinical trials of treatments involving children with ADHD and epilepsy. The full validation requires further investigations.
authors.affiliation: Service de Biostatistique, Hospices Civils de Lyon, Lyon, France; Université de Lyon, Lyon, France; Université Lyon 1, Villeurbanne, France; CNRS UMR5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France. Electronic address: catherine.mercier@chu-lyon.fr.
authors.forename: Catherine
authors.initials: C
authors.lastname: Mercier
authors.affiliation: Service de Biostatistique, Hospices Civils de Lyon, Lyon, France; Université de Lyon, Lyon, France; Université Lyon 1, Villeurbanne, France; CNRS UMR5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Roche
authors.affiliation: INSERM CIC 1407, Bron, France; CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Evaluation et modélisation des effets thérapeutiques, Villeurbanne, France; Service de Pharmacologie Clinique, Hospices Civils de Lyon, Bron, France.
authors.forename: Ségolène
authors.initials: S
authors.lastname: Gaillard
authors.affiliation: INSERM CIC 1407, Bron, France; CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Evaluation et modélisation des effets thérapeutiques, Villeurbanne, France; Service de Pharmacologie Clinique, Hospices Civils de Lyon, Bron, France.
authors.forename: Behrouz
authors.initials: B
authors.lastname: Kassai
authors.affiliation: Service Epilepsie, sommeil et explorations fonctionnelles neuropédiatriques, Hospices Civils de Lyon, Bron, France; DYCOG team, Centre de Recherche en Neurosciences de Lyon, INSERM UMR_S1028, CNRS UMR 5292, Bron, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Arzimanoglou
authors.affiliation: Service Epilepsie, sommeil et explorations fonctionnelles neuropédiatriques, Hospices Civils de Lyon, Bron, France; DYCOG team, Centre de Recherche en Neurosciences de Lyon, INSERM UMR_S1028, CNRS UMR 5292, Bron, France.
authors.forename: Vania
authors.initials: V
authors.lastname: Herbillon
authors.affiliation: Service de Biostatistique, Hospices Civils de Lyon, Lyon, France; Université de Lyon, Lyon, France; Université Lyon 1, Villeurbanne, France; CNRS UMR5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Roy
authors.affiliation: Service de Neurologie Fonctionnelle et d'Epileptologie, Hospices Civils de Lyon and Université de Lyon F-69500, Bron, France; Centre de Recherche en Neurosciences de Lyon, INSERM UMR_S1028, CNRS UMR 5292, Bron, France; Institut des Epilepsies, Bron, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Rheims
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D002648:Child; D004827:Epilepsy / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use; D011594:Psychometrics / Q000379:methods; D015203:Reproducibility of Results
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate
keywords: Adolescent; Attention deficit hyperactivity disorder; Child; Confirmatory factor analysis; Epilepsy; Validity