title: Reduced 123I Ioflupane Binding in Bilateral Diabetic Chorea: Findings With 18F FDG PET, 99mTc ECD SPECT, and 123I MIBG Scintigraphy.
abstract: We report a 64-year-old man with diabetic chorea whom we investigated with dopamine transporter SPECT, F FDG PET, Tc ethylcysteinate dimer (ECD) SPECT, and I metaiodobenzylguanidine (MIBG) scintigraphy. Dopamine transporter SPECT revealed reduced I ioflupane binding in the bilateral striatum. F FDG PET showed metabolic dysfunction in the bilateral striatum, as shown in earlier studies. Tc ECD SPECT revealed reduced brain perfusion in the bilateral caudate nucleus and putamen. I MIBG scintigraphy revealed no cardiac sympathetic nerve dysfunction. Our case suggests a possible nigrostriatal presynaptic dopaminergic involvement in diabetic chorea.
authors.affiliation: From the *Department of Neurology, and †Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Sato
authors.forename: Ayumi
authors.initials: A
authors.lastname: Hida
authors.forename: Masashi
authors.initials: M
authors.lastname: Kameyama
authors.forename: Miyako
authors.initials: M
authors.lastname: Morooka
authors.forename: Sousuke
authors.initials: S
authors.lastname: Takeuchi
mesh_terms: D019797:3-Iodobenzylguanidine; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D002819:Chorea / Q000000981:diagnostic imaging* / Q000378:metabolism; D003342:Corpus Striatum / Q000000981:diagnostic imaging; D003545:Cysteine / Q000031:analogs & derivatives; D048909:Diabetes Complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D003920:Diabetes Mellitus; D004298:Dopamine; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D017072:Neostriatum / Q000000981:diagnostic imaging* / Q000378:metabolism; D009662:Nortropanes; D015609:Organotechnetium Compounds; D049268:Positron-Emission Tomography; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013378:Substantia Nigra / Q000000981:diagnostic imaging* / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007457:Iodine Radioisotopes; D009662:Nortropanes; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D019797:3-Iodobenzylguanidine; C059659:technetium Tc 99m bicisate; D003545:Cysteine; C519528:ioflupane; D004298:Dopamine