title: The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin.
abstract: OBJECTIVE
  This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity.
  
  
  METHODS
  To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken.
  
  
  RESULTS
  In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P<0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group's measurements.
  
  
  CONCLUSIONS
  According to these results, Dxp may prevent cisplatin-induced ototoxicity.
authors.affiliation: Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, Turkey.
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Toplu
authors.affiliation: Department of Otorhinolaryngology, Malatya State Hospital, Malatya, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Sapmaz
authors.affiliation: Department of Pharmacology, Inonu University Medical Faculty, Malatya, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Parlakpinar
authors.affiliation: Department of Otorhinolaryngology, Sutcu Imam University Medical Faculty, Kahramanmaras, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kelles
authors.affiliation: Department of Otorhinolaryngology, Istanbul Medeniyet University Medical Faculty, Istanbul, Turkey.
authors.forename: M Tayyar
authors.initials: MT
authors.lastname: Kalcioglu
authors.affiliation: Department of Physiology, Inonu University Medical Faculty, Malatya, Turkey.
authors.forename: Kevser
authors.initials: K
authors.lastname: Tanbek
authors.affiliation: Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kizilay
keywords: Biomarkers; Cisplatin; Dexpanthenol; Otoacoustic Emissions; Ototoxicity