title: Translocation t(7;12) as the sole chromosomal abnormality resulting in ACTB-GLI1 fusion in pediatric gastric pericytoma.
abstract: We hereby report an unusual gastric tumor arising from the pyloric wall of the stomach in a 9-year-old child harboring the exceptionally rare translocation t(7;12) resulting in ACTB-GLI1 gene fusion. This tumor has been previously classified as pericytoma with t(7;12) and described in 6 patients, 2 of them children. We discuss the challenges in recognizing this rare entity and the importance of the molecular studies in establishing the correct diagnosis. Our case is the first report of this type arising in the stomach of a child.
authors.affiliation: Department of Pathology and Immunology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030. Electronic address: ecastro@bcm.edu.
authors.forename: Eumenia
authors.initials: E
authors.lastname: Castro
authors.affiliation: Department of Pathology and Immunology, Molecular Oncology Laboratory, Houston, TX 77030. Electronic address: CortesSantiago@bcm.edu.
authors.forename: Nahir
authors.initials: N
authors.lastname: Cortes-Santiago
authors.affiliation: Department of Pathology and Immunology, Molecular Oncology Laboratory, Houston, TX 77030. Electronic address: lmsuare1@texaschildrens.org.
authors.forename: Lizmery M Suarez
authors.initials: LM
authors.lastname: Ferguson
authors.affiliation: Department of Pediatrics, Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030. Electronic address: PHRAO@texaschildrens.org.
authors.forename: Pulivarthi H
authors.initials: PH
authors.lastname: Rao
authors.affiliation: Department of Pediatrics, Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030. Electronic address: venkatra@bcm.edu.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Venkatramani
authors.affiliation: Department of Pathology and Immunology, Molecular Oncology Laboratory, Houston, TX 77030. Electronic address: doloresl@bcm.edu.
authors.forename: Dolores
authors.initials: D
authors.lastname: López-Terrada
mesh_terms: D000199:Actins / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics*; D002648:Child; D002881:Chromosomes, Human, Pair 12; D002897:Chromosomes, Human, Pair 7; D005260:Female; D050939:Gene Fusion; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D010641:Phenotype; D013274:Stomach Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D014178:Translocation, Genetic; D000071676:Zinc Finger Protein GLI1 / Q000235:genetics*
chemical_list: D000199:Actins; D014408:Biomarkers, Tumor; C400551:GLI1 protein, human; D000071676:Zinc Finger Protein GLI1
keywords: Gastric; Pediatric; Pericytoma; Rare; Translocation; Tumor