title: Experimental study on the detection of rabbit intracranial hemorrhage using four coil structures based on magnetic induction phase shift.
abstract: Intracranial hemorrhage (ICH) is the bleeding induced by parenchyma vascular rupture. In this paper, four novel coils (a contralateral hemisphere cancellation coil, a coaxial coil, a double-end exciting coil, and a Helmholtz coil) were developed to detect the volume change of ICH with the magnetic induction phase shift (MIPS) technique. Both numerical studies on an ICH model and animal experiments on rabbits' hemorrhage model were performed with four coils. Twenty rabbits were measured for each coil. The animal results were consistent with the simulation and the theoretical analysis for each coil. The MIPS first declined and then increased with increasing injection volume, indicating the existence of a turning point. The MRI images showed that the average CSF decreased in the heads of five rabbits after blood injection was approximately equal to the average injection volume corresponding to the turning point of all animals. Thus, we concluded that when the MIPS turning point occurs, the CSF is already exhausted and the compensatory stage has ended. The results show that the MIPS technique has the potential to detect ICH growth and MIPS changes with increasing blood in a regular way. The turning point is expected to provide an early warning for ICH growth.
authors.forename: Qingguang
authors.initials: Q
authors.lastname: Yan
authors.forename: Gui
authors.initials: G
authors.lastname: Jin
authors.forename: Mingxin
authors.initials: M
authors.lastname: Qin
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
mesh_terms: D000818:Animals; D020300:Intracranial Hemorrhages / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D011817:Rabbits