title: The Association of Mean Platelet Volume with Intra Ventricular Hemorrhage and Broncho Pulmonary Dysplasia in Preterm Infants.
abstract: BACKGROUND
  Interventricular hemorrhage (IVH) and Broncho pulmonary dysplasia(BPD) commonly occur in premature infants and they associate with platelet dysfunction. The aim of this study was to investigate the association of MPV and occurrence of IVH and BPD.
  
  
  METHODS
  In this cross sectional study, 3 groups including IVH, BPD and control were compared. All participants were preterm neonates with <35 weeks of gestation. MPV was recorded during the first 48 hours of life for all cases. Data were reported by descriptive statistics and analyzed by Pearson correlation coefficient, spearman correlation coefficient, paired T test and multinomial regression analysis in SPSS version 17.
  
  
  RESULTS
  Higher MPV level was noted in BPD and IVH groups versus control group (9.79±0.73 fl and 10±1.04 fl versus 8.33±0,91 fl p<0.0001). Also, most participants in BPD (93.3%) and IVH (73.3%) groups had MPV >9 fl compared to controls (16.7%) (p<0.0001). Regression analysis showed that only MPV related to the occurrence of IVH (OR=2.200 95%CI p=0.013) and elevated MPV significantly increased duration of O2 therapy (p<0.0001) and mechanical ventilation (p=0.0010).
  
  
  CONCLUSIONS
  MPV value at first 48 hours of life can be noted as a simple biomarker for occurrence of BPD and specially IVH in preterm infants.
authors.affiliation: Pediatric growth disorders research center, 17 shahrivar hospital, school of medicine, Guilan University of medical sciences, Rasht, Iran.
authors.forename: K
authors.initials: K
authors.lastname: Bolouki Moghaddam
authors.affiliation: Pediatric growth disorders research center, 17 shahrivar hospital, school of medicine, Guilan University of medical sciences, Rasht, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Zarkesh
authors.affiliation: Pediatric growth disorders research center, 17 shahrivar hospital, school of medicine, Guilan University of medical sciences, Rasht, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Kamali
authors.affiliation: Pediatric growth disorders research center, 17 shahrivar hospital, school of medicine, Guilan University of medical sciences, Rasht, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Dalili
authors.affiliation: School of Medicine, Guilan University of Medical Sciences, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Heidarzadeh
authors.affiliation: Pediatric growth disorders research center, 17 shahrivar hospital, school of medicine, Guilan University of medical sciences, Rasht, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Hassanzadeh Rad
keywords: Bronchopulmonary dysplasia; Intraventricular hemorrhage; Mean platelet volume; preterm infants