title: A Comfort Survey of Timolol Hemihydrate 0.5% Solution Once or Twice Daily vs Timolol Maleate in Sorbate.
abstract: OBJECTIVE
  To evaluate by survey the comfort upon instillation of timolol hemihydrate compared to timolol maleate with potassium sorbate.
  
  
  METHODS
  A prospective, multicenter, observational, non-interventional study.
  
  
  METHODS
  One hundred and three patients of open-angle glaucoma or ocular hypertension who were ≥21 years old and were currently prescribed timolol hemihydrate (once or twice daily) or timolol maleate with potassium sorbate once daily as monotherapy or as a part of two-drug therapy.
  
  
  METHODS
  Study was performed at seven clinical sites in the United States. Patients were surveyed on comfort upon instillation of timolol hemihydrate compared to timolol maleate with potassium sorbate.
  
  
  RESULTS
  A difference between timolol hemihydrate and timolol maleate with potassium sorbate for questions 1 (burning/stinging on instillation, p < 0.001) and 4 (tearing on instillation, p = 0.024) was noted. There were no differences between treatment groups for any other question (p > 0.05).
  
  
  CONCLUSIONS
  This survey suggests that timolol hemihydrate is associated with less stinging/burning and tearing than timolol maleate with potassium sorbate. How to cite this article: Stewart WC, Oehler JC, Choplin NT, Markoff JI, Moster MR, Ichhpujani P, Nelson LA. A Comfort Survey of Timolol Hemihydrate 0.5% Solution Once or Twice Daily vs Timolol Maleate in Sorbate. J Current Glau Prac 2013;7(1):11-16.
authors.affiliation: Cofounder and Medical Director, PRN Pharmaceutical Research Network, LLC, Cheyenne Wyoming, USA.
authors.forename: William C
authors.initials: WC
authors.lastname: Stewart
authors.affiliation: Consultant, Northwest Eye Surgeons, Columbus, Ohio, USA.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Oehler
authors.affiliation: Consultant, Eye Care of San Diego, San Diego, California, USA.
authors.forename: Neil T
authors.initials: NT
authors.lastname: Choplin
authors.affiliation: Consultant, Philadelphia Eye Associates, Philadelphia, Pennsylvania, USA.
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Markoff
authors.affiliation: Consultant, Ophthalmic Partners of Pennsylvania, Bala-Cynwyd Pennsylvania, USA.
authors.forename: Marlene R
authors.initials: MR
authors.lastname: Moster
authors.affiliation: Consultant, Glaucoma Facility, Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, India.
authors.forename: Parul
authors.initials: P
authors.lastname: Ichhpujani
authors.affiliation: Consultant, PRN Pharmaceutical Research Network, LLC, Cheyenne Wyoming, USA.
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Nelson
keywords: Betimol; Comfort; Glaucoma; Istalol; Timolol hemihydrate; Timolol maleate with potassium sorbate.