title: Understanding of bacterial virulence using the silkworm infection model.
abstract: We have used silkworms, larva of Bombyx mori, to investigate host-pathogen interactions. Silkworms have several advantages, such as high availability of a large number of animals and ease of injection of quantitative amounts of samples. Human pathogenic bacteria such as Staphylococcus aureus, Streptococcus pyogenes, or Pseudomonas aeruginosa kill silkworms. In this review, I would like to summarize our approach identifying S. aureus virulence factors by using the silkworm infection model.
authors.affiliation: Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo.
authors.forename: Chikara
authors.initials: C
authors.lastname: Kaito
mesh_terms: D000818:Animals; D001419:Bacteria / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000382:microbiology*; D012831:Bombyx / Q000196:embryology / Q000382:microbiology*; D004195:Disease Models, Animal; D054884:Host-Pathogen Interactions; D006801:Humans; D007814:Larva / Q000382:microbiology; D013045:Species Specificity; D014774:Virulence