title: Biological Motion induced mu suppression is reduced in Early Psychosis (EP) patients with active negative symptoms and Autism Spectrum Disorders (ASD).
abstract: There is evidence of genetic and neural system overlap in Autism Spectrum Disorder (ASD) and Early Psychosis (EP). Five datasets were pooled to compare mu suppression index (MSI), a proxy of mirror neuron activity, in EP, high functioning ASD, and healthy subjects (HS). ASDs and EPs with "active" negative symptoms showed significant differences in mu suppression, in response to Biological Motion/point-light display animation, compared to HS. Preliminary findings suggest that similar neural network deficits in ASD and EP could be driven by the expression of negative symptoms in the latter group of patients. These findings may aid future studies on EP and ASD and facilitate the formulation of new hypotheses regarding their pathophysiology.
authors.affiliation: Department of Psychiatry, University of California at San Diego (UCSD), San Diego, CA, USA; Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy. Electronic address: amedeomin@gmail.com.
authors.forename: Amedeo
authors.initials: A
authors.lastname: Minichino
authors.affiliation: Department of Psychiatry, University of California at San Diego (UCSD), San Diego, CA, USA.
authors.forename: Fiza
authors.initials: F
authors.lastname: Singh
authors.affiliation: Department of Cognitive Science, University of California at San Diego (UCSD), San Diego, CA, USA.
authors.forename: Jaime
authors.initials: J
authors.lastname: Pineda
authors.affiliation: Department of Cognitive Science, University of California at San Diego (UCSD), San Diego, CA, USA.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Friederich
authors.affiliation: Department of Psychiatry, University of California at San Diego (UCSD), San Diego, CA, USA.
authors.forename: Kristin S
authors.initials: KS
authors.lastname: Cadenhead
mesh_terms: D000328:Adult; D000067877:Autism Spectrum Disorder / Q000235:genetics* / Q000503:physiopathology; D016022:Case-Control Studies; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059167:Mirror Neurons / Q000502:physiology*; D011618:Psychotic Disorders / Q000235:genetics*
keywords: Biological Motion; Early Psychosis; Mirror neurons; Negative symptoms; Posterior superior temporal sulcus