title: The transcription factor BATF modulates cytokine-mediated responses in T cells.
abstract: The transcription factor BATF (basic leucine zipper transcription factor, ATF-like), belongs to the AP-1 family of transcription factors and has been shown to be predominantly expressed in cells of haematopoietic origin, especially in B and T cells. In studies using Batf-deficient mice, a profound defect in the differentiation of T helper cells type 17 (Th17) and follicular T helper cells (Tfh) was described, as well as an impairment of antibody production with switched isotypes. More recently BATF has been described to influence also Th2 and Th9 responses in models of murine experimental asthma. In CD8(+) T cells BATF has been found associated with anti-viral responses. This review summarizes the role of BATF in CD4(+) T cell subsets and in CD8(+) T cells, with particular focus on this transcription factor in the setting of allergic asthma.
authors.affiliation: Department of Molecular Pneumology, Friedrich-Alexander University Erlangen-Nürnberg, 91052 Erlangen, Germany.
authors.forename: Nina
authors.initials: N
authors.lastname: Sopel
authors.affiliation: Department of Molecular Pneumology, Friedrich-Alexander University Erlangen-Nürnberg, 91052 Erlangen, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Graser
authors.affiliation: Department of Molecular Pneumology, Friedrich-Alexander University Erlangen-Nürnberg, 91052 Erlangen, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Mousset
authors.affiliation: Department of Molecular Pneumology, Friedrich-Alexander University Erlangen-Nürnberg, 91052 Erlangen, Germany. Electronic address: susetta.finotto@uk-erlangen.de.
authors.forename: Susetta
authors.initials: S
authors.lastname: Finotto
mesh_terms: D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000037:antagonists & inhibitors / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: C099359:BATF protein, human; D050976:Basic-Leucine Zipper Transcription Factors; D016207:Cytokines
keywords: AP-1; Asthma; BATF; T cells