title: Tonic Seizure Status Epilepticus Triggered by Valproate in a Child with Doose Syndrome.
abstract: Antiepileptic drugs may occasionally increase seizure frequency or eliciting de novo seizure occurrence; the underlying mechanism of these effects is not known. The potential adverse effects of valproic acid in myoclonic astatic epilepsy have been noted by experienced clinicians in various different regions of the world, but this important observation has not been sufficiently reported. We present the case of tonic status epilepticus in an 8-year-old boy with Doose syndrome related to valproic acid. Valproic acid, such as others antiepileptic drugs, is liable to produce paradoxical effects such as the atypical seizures we report. We emphasize the importance for the management of acute seizures in an intensive care unit setting and increase awareness of the acute toxic effects of antiepileptic drugs.
authors.affiliation: Department of Clinical Neurophysiology, General Hospital of Albacete, Albacete, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Grande-Martín
authors.affiliation: Department of Clinical Neurophysiology, General Hospital of Albacete, Albacete, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Pardal-Fernández
authors.affiliation: Department of Pediatrics, Intensive Care Unit, General Hospital of Albacete, Albacete, Spain.
authors.forename: María Carmen
authors.initials: MC
authors.lastname: Carrascosa-Romero
authors.affiliation: Neuropsychopharmacology Unit, General Hospital of Albacete, Albacete, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: De Cabo
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000188:drug therapy*; D006801:Humans; D008297:Male; D012640:Seizures / Q000139:chemically induced*; D013226:Status Epilepticus / Q000139:chemically induced*; D013577:Syndrome; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid