title: Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome.
abstract: Postprandial dyslipidaemia may be a plausible mechanism by which polycystic ovary syndrome (PCOS) increases cardiovascular risk. We sought to investigate whether the postprandial glucose and insulin and lipid and lipoprotein responses, including that of apolipoprotein B-48 (apoB-48) containing chylomicrons, to a mixed meal are different in obese PCOS women when compared to obese control subjects and whether differences, if any, are related to obesity, insulin resistance (IR), hyperandrogenaemia, or PCOS status. 26 women with PCOS (age 30.4 ± 1.2 years (mean ± SEM), body mass index (BMI) 36.8 ± 1.5 kg/m(2)) and 26 non-PCOS subjects (age 34.1 ± 0.9 years, BMI 31.5 ± 1.0 kg/m(2)) were studied before and up to 8 hours following a standard mixed meal. AUC-triglyceride (AUC-TG) was higher and AUC-high-density lipoprotein (AUC-HDL) lower in PCOS women. These differences were not apparent when BMI was accounted for. Insulin sensitivity (S I), AUC-apoB-48, and AUC-apolipoprotein B (AUC-apoB) were found to be independent predictors of AUC-TG, accounting for 55% of the variance. Only AUC-insulin remained significantly elevated following adjustment for BMI. Obesity related IR explains postprandial hypertriglyceridaemia and hyperinsulinaemic responses. Management of obesity in premenopausal women with PCOS is likely to reduce their cardiovascular risk burden.
authors.affiliation: Department of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
authors.forename: Tommy
authors.identifier: http://orcid.org/0000-0002-7570-3953
authors.initials: T
authors.lastname: Kyaw Tun
authors.affiliation: Department of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
authors.forename: Anne
authors.identifier: http://orcid.org/0000-0003-4222-622X
authors.initials: A
authors.lastname: McGowan
authors.affiliation: Department of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
authors.forename: Niamh
authors.initials: N
authors.lastname: Phelan
authors.affiliation: Department of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
authors.forename: Neuman
authors.identifier: http://orcid.org/0000-0001-6626-965X
authors.initials: N
authors.lastname: Correia
authors.affiliation: Department of Chemical Pathology, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
authors.forename: Gerard
authors.initials: G
authors.lastname: Boran
authors.affiliation: Nutrigenomics Research Group, UCD Conway Institute of Biomolecular and Biomedical Research, School of Public Health and Population Science, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Anna-Louise
authors.initials: AL
authors.lastname: O'Connor
authors.affiliation: Nutrigenomics Research Group, UCD Conway Institute of Biomolecular and Biomedical Research, School of Public Health and Population Science, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Helen M
authors.identifier: http://orcid.org/0000-0002-0628-3318
authors.initials: HM
authors.lastname: Roche
authors.affiliation: Department of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
authors.forename: James
authors.initials: J
authors.lastname: Gibney