title: A Pioneer's Tail.
abstract: In this issue of Immunity, Boller et al. (2016) show that a C-terminal domain of EBF1 is required for chromatin binding and induction of DNase I hypersensitive sites. These properties mark EBF1 as a pioneer factor in B cell development and demonstrate a role for non-DNA binding domains in this process.
authors.affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, Maryland 21224, USA. Electronic address: senra@mail.nih.gov.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Sen
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D002843:Chromatin / Q000378:metabolism*; D054503:Lymphoid Progenitor Cells / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism*
chemical_list: D002843:Chromatin; D015534:Trans-Activators