title: Methods of Inducing Inflammatory Bowel Disease in Mice.
abstract: Animal models of experimentally induced inflammatory bowel disease (IBD) are useful for understanding more about the mechanistic basis of the disease, identifying new targets for therapeutic intervention, and testing novel therapeutics. This unit provides detailed protocols for five widely used mouse models of experimentally induced intestinal inflammation: chemical induction of colitis by dextran sodium sulfate (DSS), hapten-induced colitis via 2,4,6-trinitrobenzene sulfonic acid (TNBS), Helicobacter-induced colitis in mdr1a(-/-) mice, the CD4(+) CD45RB(hi) SCID transfer colitis model, and the IL-10(-/-) colitis model. © 2016 by John Wiley & Sons, Inc.
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.|Department of Integrative Biology and Pharmacology, The University of Texas Medical School at Houston, Houston, Texas.
authors.forename: Byoungwook
authors.initials: B
authors.lastname: Bang
authors.affiliation: Department of Integrative Biology and Pharmacology, The University of Texas Medical School at Houston, Houston, Texas.
authors.forename: Lenard M
authors.initials: LM
authors.lastname: Lichtenberger
mesh_terms: D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000378:metabolism; D016264:Dextran Sulfate / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D007249:Inflammation / Q000139:chemically induced* / Q000378:metabolism; D015212:Inflammatory Bowel Diseases / Q000139:chemically induced* / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016513:Mice, SCID; D014301:Trinitrobenzenes / Q000494:pharmacology; D014302:Trinitrobenzenesulfonic Acid / Q000494:pharmacology
chemical_list: D014301:Trinitrobenzenes; D016753:Interleukin-10; C029222:sym-trinitrobenzene; D014302:Trinitrobenzenesulfonic Acid; D016264:Dextran Sulfate
keywords: IBD; colitis; model; mouse