title: Single Nucleotide Polymorphism rs10919543 in FCGR2A/FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population.
abstract: BACKGROUND
  Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population.
  
  
  METHODS
  Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014. A Chi-square test was used to test for genotype/allele frequencies variants.
  
  
  RESULTS
  Among the four SNPs, rs10919543 was found to be significantly associated with TA in the studied population. The GG genotype of rs10919543 at the FCGR2A/FCGR3A locus is a high risk factor (odds ratio [OR] = 6.532, 95% confidence interval [CI] = 2.402 - 17.763, P < 0.001) for TA. Among TA patients, the level of eosinophil granulocytes (Eos) in the peripheral blood was observed to be higher in the GG group of rs10919543 (n = 23, Eos = 0.11 [0.08, 0.17] ×109/L) than the GA + AA group (n = 100, Eos = 0.08 [0.05, 0.13] ×109/L, P = 0.028). No correlation between the genotypes of the other three SNPs and TA patients was observed.
  
  
  CONCLUSIONS
  Our findings revealed unique genetic pattern in Chinese TA patients that may be partly responsible for the higher risk of TA in this population. FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of TA.
authors.forename: Fang
authors.initials: F
authors.lastname: Qin
authors.forename: Hu
authors.initials: H
authors.lastname: Wang
authors.affiliation: Hypertension Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Song
authors.forename: Xi-Li
authors.initials: XL
authors.lastname: Lu
authors.forename: Li-Rui
authors.initials: LR
authors.lastname: Yang
authors.forename: Er-Peng
authors.initials: EP
authors.lastname: Liang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Yu-Bao
authors.initials: YB
authors.lastname: Zou
authors.forename: Jin
authors.initials: J
authors.lastname: Bian
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Wu
authors.forename: Xian-Liang
authors.initials: XL
authors.lastname: Zhou
authors.forename: Ru-Tai
authors.initials: RT
authors.lastname: Hui
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Zhang
authors.forename: Xiong-Jing
authors.initials: XJ
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics*; D013625:Takayasu Arteritis / Q000209:etiology / Q000235:genetics*
chemical_list: C445323:FCGR2A protein, human; C496124:FCGR3A protein, human; D017452:Receptors, IgG