title: Determining the Independent Risk Factors and Mortality Rate of Nosocomial Infections in Pediatric Patients.
abstract: The objective of this study was to determine the rate, independent risk factors, and outcomes of healthcare-associated infections in pediatric patients. This study was performed between 2011 and 2014 in pediatric clinic and intensive care unit. 86 patients and 86 control subjects were included in the study. Of 86 patients with nosocomial infections (NIs), there were 100 NIs episodes and 90 culture growths. The median age was 32.0 months. The median duration of hospital stay of the patients was 30.0 days. The most frequent pathogens were Coagulase-negative Staphylococcus, Acinetobacter spp., Klebsiella spp., and Candida spp. Unconsciousness, prolonged hospitalization, transfusion, mechanical ventilation, use of central venous catheter, enteral feeding via a nasogastric tube, urinary catheter, and receiving carbapenems and glycopeptides were found to be significantly higher in NIs patients. Multivariate logistic regression analysis showed prolonged hospitalization, neutropenia, and use of central venous catheter and carbapenems as the independent risk factors for NIs. In the univariate analysis, unconsciousness, mechanical ventilation, enteral feeding, use of enteral feeding via a nasogastric tube, H2 receptor blockers, and port and urinary catheter were significantly associated with mortality. In the multiple logistic regression analysis, only mechanical ventilation was found as an independent predictor of mortality in patients with NIs.
authors.affiliation: Department of Pediatric Intensive Care Unit, Dicle University Medical School, 21010 Diyarbakir, Turkey.
authors.forename: Fesih
authors.initials: F
authors.lastname: Aktar
authors.affiliation: Dicle University School of Medicine, Clinical Microbiology and Infectious Diseases, 21010 Diyarbakir, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Tekin
authors.affiliation: Department of Pediatric Intensive Care Unit, Dicle University Medical School, 21010 Diyarbakir, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Güneş
authors.affiliation: Department of Pediatrics, Dicle University Medical School, 21010 Diyarbakir, Turkey.
authors.forename: Cevat
authors.initials: C
authors.lastname: Ülgen
authors.affiliation: Department of Pediatrics, Dicle University Medical School, 21010 Diyarbakir, Turkey.
authors.forename: İlhan
authors.initials: İ
authors.lastname: Tan
authors.affiliation: Department of Pediatrics, Dicle University Medical School, 21010 Diyarbakir, Turkey.
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Ertuğrul
authors.affiliation: Department of Pediatric Infectious Diseases, Diyarbakir Children's Hospital, Diyarbakir, Turkey.
authors.forename: Muhammet
authors.initials: M
authors.lastname: Köşker
authors.affiliation: Department of Pediatrics, Dicle University Medical School, 21010 Diyarbakir, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Balık
authors.affiliation: Department of Pediatrics, Dicle University Medical School, 21010 Diyarbakir, Turkey.
authors.forename: Duran
authors.initials: D
authors.lastname: Karabel
authors.affiliation: Department of Pediatrics, Dicle University Medical School, 21010 Diyarbakir, Turkey.
authors.forename: Ilyas
authors.initials: I
authors.lastname: Yolbaş
mesh_terms: D002175:Candida / Q000302:isolation & purification / Q000472:pathogenicity; D015780:Carbapenems / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D008297:Male; D009026:Mortality; D010372:Pediatrics; D012121:Respiration, Artificial; D012307:Risk Factors
chemical_list: D015780:Carbapenems