title: Inside story of Group I Metabotropic Glutamate Receptors (mGluRs).
abstract: Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that are activated by the neurotransmitter glutamate in the central nervous system. Among the eight subtypes, mGluR1 and mGluR5 belong to the group I family. These receptors play important roles in the brain and are believed to be involved in multiple forms of experience dependent synaptic plasticity including learning and memory. In addition, group I mGluRs also have been implicated in various neuropsychiatric disorders like Fragile X syndrome, autism etc. The normal signaling depends on the precise location of these receptors in specific region of the neuron and the process of receptor trafficking plays a crucial role in controlling this localization. Intracellular trafficking could also regulate the desensitization, resensitization, down-regulation and intracellular signaling of these receptors. In this review I focus on the current understanding of group I mGluR regulation in the central nervous system and also their role in neuropsychiatric disorders.
authors.affiliation: Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge city, Sector-81, SAS Nagar, PO: 140306, Punjab, India. Electronic address: samarjit@iisermohali.ac.in.
authors.forename: Samarjit
authors.initials: S
authors.lastname: Bhattacharyya
mesh_terms: D000818:Animals; D006801:Humans; D001523:Mental Disorders / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009473:Neuronal Plasticity; D021381:Protein Transport; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018094:Receptors, Metabotropic Glutamate
keywords: Desensitization; Endocytosis; GPCR; Metabotropic glutamate receptors; Neurotransmitter receptors; Receptor recycling; Trafficking