title: Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three-Component Synthesis of Functionalized α-Ketoamides.
abstract: Using a flow microreactor system, carbamoyllithium compounds were successfully generated and used for reactions with electrophiles to give various amides, including α-ketoamides. The present method could be applied to the three-component synthesis of functionalized α-ketoamides using a carbamoyllithium compound, methyl chloroformate, and a functionalized organolithium reagent.
authors.affiliation: Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan. anagaki@sbchem.kyoto-u.ac.jp.
authors.forename: Aiichiro
authors.initials: A
authors.lastname: Nagaki
authors.affiliation: Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan. yoshida@sbchem.kyoto-u.ac.jp.
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Yoshida
keywords: amides; carbonyl groups; flow chemistry; lithiation; microreactors