title: Exercise as an intervention for first-episode psychosis: a feasibility study.
abstract: Exercise can improve psychiatric symptoms, neurocognitive functioning and physical health in schizophrenia. However, the effects in early psychosis have not been explored. This study aimed to assess the feasibility of an exercise intervention for early psychosis and to determine if it was associated with changes in physical and mental health.
  
  
  
  Thirty-one patients with first-episode psychosis (FEP) were recruited from early intervention services to a 10-week exercise intervention. The intervention group received individualized training programmes, aiming to achieve ≥90 min of moderate-to-vigorous activity each week, using exercise programmes tailored to individual preferences and needs. A comparison FEP sample from the same services (n = 7) received treatment as usual.
  
  
  
  Rates of consent and retention in the exercise group were 94% and 81%, respectively. Participants achieved an average of 107 min of moderate-to-vigorous exercise per week. Positive and Negative Syndrome Scale total scores reduced by 13.3 points after 10 weeks of exercise, which was significantly greater than the treatment as usual comparison group (P = 0.010). The greatest differences were observed in negative symptoms, which reduced by 33% in the intervention group (P = 0.013). Significant improvements were also observed in psychosocial functioning and verbal short-term memory. Increases in cardiovascular fitness and processing speed were positively associated with the amounts of exercise achieved by participants.
  
  
  
  Individualized exercise training could provide a feasible treatment option for improving symptomatic, neurocognitive and metabolic outcomes in FEP.
authors.affiliation: Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK.
authors.forename: Joseph
authors.initials: J
authors.lastname: Firth
authors.affiliation: Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK.
authors.forename: Rebekah
authors.identifier: 0000-0002-2859-6825
authors.initials: R
authors.lastname: Carney
authors.affiliation: Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK.|Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Elliott
authors.affiliation: Greater Manchester West NHS Mental Health Foundation Trust, Manchester, UK.|Department of Psychological Sciences, The University of Liverpool, Liverpool, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: French
authors.affiliation: Greater Manchester West NHS Mental Health Foundation Trust, Manchester, UK.|School of Psychological Sciences, University of Manchester, Manchester, UK.
authors.forename: Sophie
authors.initials: S
authors.lastname: Parker
authors.affiliation: Lincolnshire Partnership NHS Foundation Trust, Lincolnshire, UK.
authors.forename: Rebecca
authors.initials: R
authors.lastname: McIntyre
authors.affiliation: School of Healthcare Science, Manchester Metropolitan University, Manchester, UK.
authors.forename: Jamie S
authors.initials: JS
authors.lastname: McPhee
authors.affiliation: Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK.|Greater Manchester West NHS Mental Health Foundation Trust, Manchester, UK.
authors.forename: Alison R
authors.initials: AR
authors.lastname: Yung
mesh_terms: D000293:Adolescent; D000328:Adult; D003071:Cognition; D061345:Early Medical Intervention / Q000379:methods*; D005081:Exercise Therapy; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D010809:Physical Fitness; D011618:Psychotic Disorders / Q000523:psychology / Q000628:therapy*; D012919:Social Behavior; D055815:Young Adult
keywords: early intervention; exercise; physical activity; physical health; schizophrenia