title: Nano-biomaterials for cardiovascular applications: Clinical perspective.
abstract: Cardiovascular diseases, including ischemic heart disease and stroke, are responsible for nearly 25% of all deaths worldwide. Globally, their prevalence continues to increase, in spite of enormous progress in cardiovascular diagnostics and therapy. For therapeutic and regenerative purposes, biomaterials promise solutions with multiple advantages over synthetic materials. Furthermore, their easy availability as nanoformulations recommends their application as drug carriers or protective nanoshells improving the biocompatibility of imaging agents. In this work, we review the most promising and clinically meaningful scientific reports with regard to (nano)biomaterials with particular focus on potential improvements of existing, and development of novel constructs for cardiovascular applications.
authors.affiliation: Cardiovascular Nanomedicine Unit, Section of Experimental Oncology and Nanomedicine, ENT-Department, University Hospital Erlangen, Germany. Electronic address: Iwona.Cicha@yahoo.com.
authors.forename: Iwona
authors.initials: I
authors.lastname: Cicha
authors.affiliation: Cardiovascular Nanomedicine Unit, Section of Experimental Oncology and Nanomedicine, ENT-Department, University Hospital Erlangen, Germany.
authors.forename: Raminder
authors.initials: R
authors.lastname: Singh
authors.affiliation: Internal Medicine Clinic, Diako-Hospital, Flensburg, Germany.
authors.forename: Christoph D
authors.initials: CD
authors.lastname: Garlichs
authors.affiliation: Cardiovascular Nanomedicine Unit, Section of Experimental Oncology and Nanomedicine, ENT-Department, University Hospital Erlangen, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Alexiou
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001807:Blood Vessel Prosthesis; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D049329:Nanostructures / Q000627:therapeutic use*; D012038:Regeneration; D015607:Stents; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials
keywords: Biomaterials; Bioresorbable vascular stents; Cardiac patches; Cardiovascular tissue engineering; Drug delivery nanosystems; Vascular grafts