title: Preliminary Pharmacological Screening of Some Thiosemicarbazide, s-triazole, and Thiadiazole Derivatives.
abstract: Two thiosemicarbazide derivatives 1 and 2, three 2-amino-1,3,4-thiadiazole derivatives 3-5, and three N1- substituted-4-methyl-1,2,4-triazole-5-thione derivatives 6-8 were synthesized and evaluated for their central nervous system effects using rodent behavioral models. With the exception of 6, all compounds were devoid of neurotoxicity and they did not affect the body temperature of mice. New lead structures 1-4 with potential analgesic activity were identified.
authors.affiliation: Department of Organic Chemistry, Medical University of Lublin, Poland. agata.paneth@umlub.pl.
authors.forename: Agata
authors.initials: A
authors.lastname: Paneth
authors.forename: Monika
authors.initials: M
authors.lastname: Wujec
authors.forename: Tomasz
authors.initials: T
authors.lastname: Plech
authors.forename: Edyta
authors.initials: E
authors.lastname: Kuśmierz
authors.forename: Dominika
authors.initials: D
authors.lastname: Hagel
authors.forename: Szymon
authors.initials: S
authors.lastname: Kosiek
authors.forename: Ewa
authors.initials: E
authors.lastname: Jagiello-Wójtowicz
authors.forename: Iwona
authors.initials: I
authors.lastname: Piątkowska-Chmiel
authors.forename: Mariola
authors.initials: M
authors.lastname: Herbet
authors.forename: Magdalena
authors.initials: M
authors.lastname: Izdebska
authors.forename: Ewa
authors.initials: E
authors.lastname: Kędzierska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Orzelska-Górka
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001007:Anxiety / Q000188:drug therapy; D001831:Body Temperature / Q000187:drug effects; D002491:Central Nervous System Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D003863:Depression / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D059226:Nociceptive Pain / Q000188:drug therapy; D012640:Seizures / Q000188:drug therapy; D012663:Semicarbazides / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D012890:Sleep / Q000187:drug effects; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000700:Analgesics; D002491:Central Nervous System Agents; D012663:Semicarbazides; D013830:Thiadiazoles; D014230:Triazoles; C005151:thiosemicarbazide