title: Association Between LYPLAL1 rs12137855 Polymorphism With Ultrasound-Defined Non-Alcoholic Fatty Liver Disease in a Chinese Han Population.
abstract: BACKGROUND
  Recent genome-wide association studies (GWAS) identified that gene Lysophospholipase-like 1 (LYPLAL1) rs12137855 associated with non-alcoholic fatty liver disease (NAFLD). No research has been performed regarding the association between LYPLAL1 and NAFLD in China.
  
  
  OBJECTIVE
  The aim of the present study was to investigate the association between the gene LYPLAL1 rs12137855 and NAFLD, and the effect on serum lipid profiles in a Chinese Han population.
  
  
  METHODS
  LYPLAL1 rs12137855 gene was genotyped in 184 patients with NAFLD and 114 healthy controls using sequencing and polymerase chain reaction analysis (PCR). We tested serum lipid profiles using biochemical methods.
  
  
  RESULTS
  No significant differences in genotype and allele frequencies of LYPLAL1 rs12137855 was found between the NAFLD group and the controls group (P > 0.05). Subjects with the variant LYPLAL1 rs12137855 CC genotype had a higher mean weight, body mass index (BMI) and low density lipoprotein (LDL).
  
  
  CONCLUSIONS
  Our results showed for the first time that LYPLAL1 gene is not associated with a risk of NAFLD development in the Chinese Han population. The variant carriers of overall subjects significantly increased weight, BMI and LDL.
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yuan
authors.affiliation: Digestive Disease Key Laboratory of Qingdao, Qingdao, China; Central Laboratories, Qingdao Municipal Hospital, Qingdao, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China; Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China.
authors.forename: Baiquan
authors.initials: B
authors.lastname: An
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Jin
authors.affiliation: Central Laboratories, Qingdao Municipal Hospital, Qingdao, China; Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China.
authors.forename: Quanjiang
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China; Digestive Disease Key Laboratory of Qingdao, Qingdao, China; Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China.
authors.forename: Yongning
authors.initials: Y
authors.lastname: Xin
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China.
authors.forename: Shiying
authors.initials: S
authors.lastname: Xuan
keywords: LYPLAL1; Non-Alcoholic Fatty Liver Disease; Single Nucleotide Polymorphism