title: Evaluation of Clinical Metrology Instrument in Dogs with Osteoarthritis.
abstract: BACKGROUND
  In veterinary clinical pain studies, there is a paucity of data on test-retest variability in Clinical Metrology Instruments (CMIs), and it is unknown whether CMIs should be administered using independent (respondents not permitted to see previous answers) or dependent (respondents shown previous answers) interviewing.
  
  
  OBJECTIVE
  To compare baseline variability in CMIs designed to assess pain in dogs with osteoarthritis, and compare CMI scores using independent (InD) and dependent interviewing (DI) for the Canine Brief Pain Inventory (CBPI) and the Client-Specific Outcome Measures (CSOM).
  
  
  METHODS
  Fifty-one client-owned dogs with radiographic evidence of osteoarthritis and associated pain.
  
  
  METHODS
  Clinical Metrology Instruments data were collected during 2 randomized, double-masked, placebo-controlled, proof of principle pilot studies with parallel treatment groups. Enrolled dogs received either placebo or antinerve growth factor antibody (NV-01).
  
  
  RESULTS
  Agreement between baseline CMI scores was good (CBPI Pain P = .29, CBPI Interference P = .32, CSOM P = .036, LOAD P = .67, HCPI P = .27), being best for the LOAD (ICC = 0.89). CMI responses collected during independent and dependent interviewing were not statistically different (CBPI Pain P = .33, CBPI Interference P = .28, CSOM P = .42) and showed good agreement. Additionally, dependent interviewing resulted in increased treatment effect sizes.
  
  
  CONCLUSIONS
  There is little difference between independent and dependent interviewing, however, dependent interviewing resulted in increased treatment effect sizes. By using dependent interviewing, investigators could increase clinical trial power through minimal change to study design. Further research is warranted to investigate the use of dependent interviewing.
authors.affiliation: Comparative Pain Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
authors.forename: C
authors.initials: C
authors.lastname: Muller
authors.affiliation: Department of Statistics, North Carolina State University, Raleigh, NC.
authors.forename: B
authors.initials: B
authors.lastname: Gaines
authors.affiliation: Comparative Pain Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.|Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
authors.forename: M
authors.initials: M
authors.lastname: Gruen
authors.affiliation: Comparative Pain Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
authors.forename: B
authors.initials: B
authors.lastname: Case
authors.affiliation: Comparative Pain Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
authors.forename: K
authors.initials: K
authors.lastname: Arrufat
authors.affiliation: Chester Gates Referral Hospital, Chester, UK.
authors.forename: J
authors.initials: J
authors.lastname: Innes
authors.affiliation: Comparative Pain Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.|Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.|Center for Pain Research and Innovation, UNC School of Dentistry, Chapel Hill, NC.
authors.forename: B D X
authors.initials: BD
authors.lastname: Lascelles
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use; D004283:Dog Diseases / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D004285:Dogs; D004311:Double-Blind Method; D007167:Immunotherapy / Q000662:veterinary; D020932:Nerve Growth Factor / Q000276:immunology; D010003:Osteoarthritis / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D010146:Pain / Q000188:drug therapy / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary*; D010865:Pilot Projects; D000075082:Proof of Concept Study
chemical_list: D000906:Antibodies; D020932:Nerve Growth Factor
keywords: Analgesia; Client metrology instrument; Degenerative joint disease; Questionnaire