title: In vitro study on an antibacterial Ti-5Cu alloy for medical application.
abstract: Health of human beings is subjected to severe threats from the spread of harmful bacteria and the implant-associated infection remains a serious problem in clinic. In this study, a copper-bearing antibacterial titanium alloy, Ti-5Cu, has been developed for dental and orthopedic implant applications. The microstructure, mechanical property, electrochemical corrosion behavior, in vitro antibacterial performance, cytocompatibility and hemocompatibility of the alloy are systematically investigated. The results reveal that the Ti-5Cu alloy which consists of α-phase matrix and intermetallic compound Ti2Cu not only possesses strong antibacterial activity against both E. coli and S. aureus, but also exhibits better mechanical properties than the commercial pure titanium. It is confirmed that the release of trace amount of Cu ions from the alloy plays an important role in killing bacteria. In spite of the ion release, Ti-5Cu alloy still reveals excellent corrosion resistance. Moreover, good cytocompatibility and superior hemocompatibility make Ti-5Cu alloy to be a potential solution that could prevent the peri-implant infection in dental and orthopaedic applications.
authors.affiliation: Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen, China.|Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Orthopedic Department, Guangzhou Military General Hospital, Guangzhou, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.affiliation: Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.affiliation: Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Ren
authors.affiliation: Orthopedic Department, Guangzhou Military General Hospital, Guangzhou, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen, China.
authors.forename: Haobo
authors.initials: H
authors.lastname: Pan
authors.affiliation: Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen, China. ying.zhao@siat.ac.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China. kyang@imr.ac.cn.
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
mesh_terms: D016475:3T3 Cells; D000497:Alloys / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents; D001792:Blood Platelets / Q000502:physiology; D002448:Cell Adhesion; D049109:Cell Proliferation; D002470:Cell Survival; D003300:Copper / Q000737:chemistry*; D055664:Electrochemical Techniques; D004926:Escherichia coli / Q000187:drug effects; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D008422:Materials Testing; D051379:Mice; D013211:Staphylococcus aureus / Q000187:drug effects; D013314:Stress, Mechanical; D014025:Titanium / Q000737:chemistry*
chemical_list: D000497:Alloys; D000900:Anti-Bacterial Agents; D003300:Copper; D014025:Titanium