title: Cu(I)-Catalyzed Asymmetric Multicomponent Cascade Inverse Electron-Demand Aza-Diels-Alder/Nucleophilic Addition/Ring-Opening Reaction Involving 2-Methoxyfurans as Efficient Dienophiles.
abstract: An unprecedented multicomponent cascade asymmetric inverse-electron-demand Diels-Alder/nucleophilic addition/ring-opening reaction involving 2-methoxyfurans as efficient dienophiles was successfully developed with Cu(I)/(t)Bu-Box complex as the catalyst. A diverse array of tetrahydropyridazines containing unexpectedly stable γ-hydroxyl ester moiety was obtained in generally good yield with exclusive regioselectivity and excellent stereoselectivity.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Hubei, China 430072.
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Hubei, China 430072.
authors.forename: Xin
authors.initials: X
authors.lastname: Chang
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Hubei, China 430072.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Hubei, China 430072.|State Key Laboratory of Elemento-organic Chemistry, Nankai University , Tianjin, China 300071.
authors.forename: Chun-Jiang
authors.initials: CJ
authors.lastname: Wang
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004583:Electrons; D005663:Furans / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001372:Aza Compounds; D005663:Furans; D006835:Hydrazones; C000608973:2-methoxyfuran; D003300:Copper