title: [Colorectal cancer screening based on quantitative determining of fecal hemoglobin and transferrin].
abstract: To reduce mortality rate from cancer there has been developed a program of colorectal cancer screening. It was conducted a pilot implementation of the methodology of colorectal cancer screening based on quantitative immunochemical determination of fecal hemoglobin and transferrin with colonoscopy. The study included 10307 men and women aged 50 years and older without symptoms of the disease who received containers for a 2-day collection of stool samples. There were returned 9455 sets with samples (91.8%). Of these an excess hemoglobin level and/or transferrin above the threshold was in 1354 (14.3%). 1164 patients (86% of positive) underwent colonoscopy. Colon diseases were found in 662 patients including polyps in 237. The efficiency of a 2-day test to detect polyps was significantly higher compared to a 1-day. Colorectal cancer was revealed in 23 people--2.4 per 1000 patients. 87% of patients had cancer of stages I and II, 13%--in stage III. The results of the introduction of screening program confirm the possibility of its use in practical public health.
authors.forename: A V
authors.initials: AV
authors.lastname: Filimonov
authors.forename: E V
authors.initials: EV
authors.lastname: Kotlyarov
authors.forename: E V
authors.initials: EV
authors.lastname: Bilan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000517:prevention & control*; D055088:Early Detection of Cancer / Q000295:instrumentation / Q000379:methods*; D005243:Feces / Q000737:chemistry; D005260:Female; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000295:instrumentation / Q000379:methods*; D008875:Middle Aged; D009780:Occult Blood; D013048:Specimen Handling; D014168:Transferrin / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D006454:Hemoglobins; D014168:Transferrin