title: Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis.
abstract: Succinate is an important metabolite at the cross-road of several metabolic pathways, also involved in the formation and elimination of reactive oxygen species. However, it is becoming increasingly apparent that its realm extends to epigenetics, tumorigenesis, signal transduction, endo- and paracrine modulation and inflammation. Here we review the pathways encompassing succinate as a metabolite or a signal and how these may interact in normal and pathological conditions.(1).
authors.affiliation: Department of Medical Biochemistry, Semmelweis University, Budapest 1094, Hungary. Electronic address: laszlo.tretter@eok.sote.hu.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Tretter
authors.affiliation: MTA-SE Lendület Hereditary Endocrine Tumours Research Group, Budapest 1088, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Patocs
authors.affiliation: Department of Medical Biochemistry, Semmelweis University, Budapest 1094, Hungary; MTA-SE Lendület Neurobiochemistry Research Group, Budapest 1094, Hungary.
authors.forename: Christos
authors.initials: C
authors.lastname: Chinopoulos
mesh_terms: D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism; D053858:Metabolic Networks and Pathways / Q000235:genetics; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D019899:Paracrine Communication / Q000235:genetics; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013385:Succinate Dehydrogenase / Q000235:genetics / Q000378:metabolism*; D019802:Succinic Acid / Q000378:metabolism
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D021122:Protein Subunits; D017382:Reactive Oxygen Species; D043562:Receptors, G-Protein-Coupled; D019802:Succinic Acid; D013385:Succinate Dehydrogenase
keywords: Cancer; HIF1-alpha; Substrate-level phosphorylation; Succinate dehydrogenase; Succinate receptor