title: Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease.
abstract: Lyme disease (LD) is a systemic disorder caused by Borrelia burgdorferi. Lyme spirochetes encode for a functional 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR EC 1.1.1.88) serving as a rate limiting enzyme of the mevalonate pathway that contribute to components critical for cell wall biogenesis. Statins have been shown to inhibit B. burgdorferi in vitro. Using a mouse model of Lyme disease, we found that statins contribute to reducing bacterial burden and altering the murine immune response to favor clearance of spirochetes.
authors.affiliation: South Texas Center for Emerging Infectious Diseases, Center for Excellence in Infection Genomics and Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
authors.forename: Tricia A
authors.initials: TA
authors.lastname: Van Laar
authors.affiliation: South Texas Center for Emerging Infectious Diseases, Center for Excellence in Infection Genomics and Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
authors.forename: Camaron
authors.initials: C
authors.lastname: Hole
authors.affiliation: South Texas Center for Emerging Infectious Diseases, Center for Excellence in Infection Genomics and Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Rajasekhar Karna
authors.affiliation: South Texas Center for Emerging Infectious Diseases, Center for Excellence in Infection Genomics and Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
authors.forename: Christine L
authors.initials: CL
authors.lastname: Miller
authors.affiliation: The Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78249, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Reddick
authors.affiliation: South Texas Center for Emerging Infectious Diseases, Center for Excellence in Infection Genomics and Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
authors.forename: Floyd L
authors.initials: FL
authors.lastname: Wormley
authors.affiliation: South Texas Center for Emerging Infectious Diseases, Center for Excellence in Infection Genomics and Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA. Electronic address: j.seshu@utsa.edu.
authors.forename: J
authors.initials: J
authors.lastname: Seshu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D058491:Bacterial Load; D025065:Borrelia burgdorferi / Q000187:drug effects* / Q000302:isolation & purification; D005260:Female; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage*; D008193:Lyme Disease / Q000276:immunology* / Q000382:microbiology*; D008809:Mice, Inbred C3H; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007155:Immunologic Factors
keywords: Borrelia burgdorferi; Cell wall biogenesis; Lyme disease; Statins