title: p73 and FoxJ1: Programming Multiciliated Epithelia.
abstract: The mysteriously diverse phenotypes in mice lacking the p53 homolog p73 are recently unified by new analysis showing p73 is required for formation of multiciliated epithelia. p73 directly activates FoxJ1, the central transcriptional driver for multiciliation, and induces a host of genes critical for ciliogenesis.
authors.affiliation: Stanford University School of Medicine, Baxter Laboratory, Departments of Microbiology and Immunology and Pathology, Stanford, CA 94305, USA. Electronic address: pjackson@stanford.edu.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Jackson
authors.affiliation: Stanford University School of Medicine, Department of Radiation Oncology and Department of Genetics, Stanford, CA 94305, USA.
authors.forename: Laura D
authors.initials: LD
authors.lastname: Attardi
mesh_terms: D000818:Animals; D016764:Cell Polarity; D002923:Cilia / Q000235:genetics / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D004848:Epithelium / Q000254:growth & development / Q000378:metabolism*; D051858:Forkhead Transcription Factors / Q000172:deficiency / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D005838:Genotype; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D010750:Phosphoproteins / Q000172:deficiency / Q000235:genetics*; D015398:Signal Transduction; D015534:Trans-Activators / Q000172:deficiency / Q000235:genetics*; D014158:Transcription, Genetic; D000072160:Tumor Protein p73 / Q000172:deficiency / Q000235:genetics*
chemical_list: C481963:FOXJ1 protein, mouse; D051858:Forkhead Transcription Factors; D010750:Phosphoproteins; D015534:Trans-Activators; C486419:Trp63 protein, mouse; C000606368:Trp73 protein, mouse; D000072160:Tumor Protein p73
keywords: Primary cilia; differentiation; multiciliated epithelia; p53; p63; p73