title: Crosstalk between Long Noncoding RNAs and MicroRNAs in Health and Disease.
abstract: Protein-coding genes account for only a small part of the human genome; in fact, the vast majority of transcripts are comprised of non-coding RNAs (ncRNAs) including long ncRNAs (lncRNAs) and small ncRNAs, microRNAs (miRs). Accumulating evidence indicates that ncRNAs could play critical roles in regulating many cellular processes which are often implicated in health and disease. For example, ncRNAs are aberrantly expressed in cancers, heart diseases, and many other diseases. LncRNAs and miRs are therefore novel and promising targets to be developed into biomarkers for diagnosis and prognosis as well as treatment options. The interaction between lncRNAs and miRs as well as its pathophysiological significance have recently been reported. Mechanistically, it is believed that lncRNAs exert "sponge-like" effects on various miRs, which subsequently inhibits miR-mediated functions. This crosstalk between two types of ncRNAs frequently contributes to the pathogenesis of the disease. In this review, we provide a summary of the recent studies highlighting the interaction between these ncRNAs and the effects of this interaction on disease pathogenesis and regulation.
authors.affiliation: Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. abayoumi@gru.edu.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Bayoumi
authors.affiliation: Department of Internal Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. asayed@gru.edu.
authors.forename: Amer
authors.initials: A
authors.lastname: Sayed
authors.affiliation: Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. zbroskova@gru.edu.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Broskova
authors.affiliation: Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. jteoh@gru.edu.
authors.forename: Jian-Peng
authors.initials: JP
authors.lastname: Teoh
authors.affiliation: Department of Internal Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. jamwilson@gru.edu.
authors.forename: James
authors.initials: J
authors.lastname: Wilson
authors.affiliation: Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. hsu@gru.edu.
authors.forename: Huabo
authors.initials: H
authors.lastname: Su
authors.affiliation: Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. yaotang@gru.edu.
authors.forename: Yao-Liang
authors.initials: YL
authors.lastname: Tang
authors.affiliation: Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. ilkim@gru.edu.|Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. ilkim@gru.edu.
authors.forename: Il-Man
authors.initials: IM
authors.lastname: Kim
mesh_terms: D004194:Disease / Q000235:genetics*; D018450:Disease Progression; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding
keywords: cancer; chromatin; epigenetic regulation; gene regulation; heart disease; non-coding RNAs