title: Overview of Flaxseed Patent Applications for the Reduction of Cholesterol Levels.
abstract: BACKGROUND
  Flaxseed is becoming an increasingly widely used food ingredient. The rising interest of the food industry in this nutraceutical is primarily because of functional nutrients, such as alpha-linolenic acid and lignans, which have health benefits due to their lipid-lowering properties.
  
  
  OBJECTIVE
  The objective of this study was to provide an overview of the patenting of flaxseed products with cholesterol-lowering effects.
  
  
  METHODS
  Patent applications filed by country of origin were retrieved from the Derwent Innovations Index®database.
  
  
  RESULTS
  A total of 307 patent documents were identified, of which 184 claim the use of flaxseed or parts of the flax plant in the product formulation, for their lipid-lowering effect when consumed by humans. A few of the patent applications contain claims for new products based on flaxseed in isolation, including the preparation of foods designed to inhibit the production of cholesterol. Most of the claims were for flaxseed in the form of oil and in association with other lipid-lowering compounds, mainly for the food industry, in the form of dietary supplements or baked products designed to raise their high-density lipoprotein content, and for treating heart problems. China and the United States are the leading countries of flax-related applications.
  
  
  CONCLUSIONS
  These results may have important implications for the production of functional food products that meet specific societal demands.
authors.forename: Simone A
authors.initials: SA
authors.lastname: Ribas
authors.forename: Rafaela L
authors.initials: RL
authors.lastname: Grando
authors.forename: Lilia
authors.initials: L
authors.lastname: Zago
authors.forename: Elvira
authors.initials: E
authors.lastname: Carvajal
authors.affiliation: Universidade do Estado do Rio de Janeiro; Centro Biomédico; Laboratório de Desenvolvimento Estratégico do Centro Biomédico; Rua São Francisco Xavier 524, sala 2144F, Maracanã, Rio de Janeiro, RJ, Brazil..
authors.forename: Iolanda M
authors.initials: IM
authors.lastname: Fierro
mesh_terms: D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002784:Cholesterol; D019597:Flax / Q000737:chemistry*; D006801:Humans; D006937:Hypercholesterolemia / Q000628:therapy*; D010330:Patents as Topic; D012639:Seeds; D017962:alpha-Linolenic Acid
chemical_list: D000924:Anticholesteremic Agents; D017962:alpha-Linolenic Acid; D002784:Cholesterol
keywords: Cholesterol; flaxseed; flaxseed products; functional food; linseed; nutraceuticals; patent