title: Introduction and overview of the special issue "Brain imaging and aging": The new era of neuroimaging in aging research.
abstract: It is well known that the brain is one of the organs particularly affected by aging in terms of function, relative to the gastrointestinal tract and liver, which exhibit less functional decline. There is also a wide range of age-related neurological disorders such as stroke, Alzheimer's disease, and Parkinson's disease. Therefore, it is very important to understand the relationship between functional age-related change and neurological dysfunction. Neuroimaging techniques including magnetic resonance imaging and positron emission tomography have been significantly improved over recent years. Many physicians and researchers have investigated various mechanisms of age-related cerebral change and associated neurological disorders using neuroimaging techniques. In this special issue of Ageing Research Reviews, we focus on cerebral- and neuro-imaging, which are a range of tools used to visualize structure, functions, and pathogenic molecules in the nervous system. In addition, we summarize several review articles about the history, present values, and future perspectives of neuroimaging modalities.
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan. Electronic address: kfurukawa-ns@umin.ac.jp.
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Furukawa
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Aiko
authors.initials: A
authors.lastname: Ishiki
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Tomita
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Onaka
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Saito
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakamichi
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Hara
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kusano
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Masamune
authors.initials: M
authors.lastname: Ebara
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Arata
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Miku
authors.initials: M
authors.lastname: Sakota
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Miyazawa
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Totsune
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Okinaga
authors.affiliation: Department of Pharmacology, Tohoku University School of Medicine, Japan; Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Okamura
authors.affiliation: Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Yukitsuka
authors.initials: Y
authors.lastname: Kudo
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
mesh_terms: D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000473:pathology; D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development* / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D059906:Neuroimaging / Q000639:trends*; D012106:Research
keywords: Aging; Amyloid; MRI; Neuroimaging; PET; Tau