title: Two novel phenanthraquinones with anti-cancer activity isolated from Bletilla striata.
abstract: 7-Hydroxy-2-methoxy-phenanthrene-3,4-dione and 3',7',7-trihydroxy-2,2',4'-trimethoxy-[1,8'-biphenanthrene]-3,4-dione, two novel compounds and four known compounds were isolated from Bletilla striata. The structures of the compounds were established on the basis of extensive spectroscopic analysis. The two compounds exhibited antiproliferative effects using the MTT test; these effects may be due to cell cycle arrest and inducing ROS generation.
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, Fujian, China; Department of Clinical Pharmacy, The 180th Hospital of the People's Liberation Army, Quanzhou 362000, Fujian, China.
authors.forename: Aijing
authors.initials: A
authors.lastname: Sun
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, Fujian, China.
authors.forename: Jieqing
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, Fujian, China; Department of Clinical Pharmacy, The 180th Hospital of the People's Liberation Army, Quanzhou 362000, Fujian, China.
authors.forename: Suqiu
authors.initials: S
authors.lastname: Pang
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, Fujian, China.
authors.forename: Junsheng
authors.initials: J
authors.lastname: Lin
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, Fujian, China. Electronic address: ruianxu@hqu.edu.cn.
authors.forename: Ruian
authors.initials: R
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D029595:Orchidaceae / Q000737:chemistry*; D011809:Quinones / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011809:Quinones
keywords: Anti-tumor activity; Bletilla striata; Cell cycle arrest; Phenanthraquinone; Reactive oxygen species