title: Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals.
abstract: Design, synthesis and single-crystal conformations of hybrid triple-stranded β-sheets composed of E-vinylogous residues are reported. Restricting conformational flexibility of β-strands through the insertion of carbon-carbon double bonds at facing positions leads to increased peptide crystallinity, which allowed unambiguous structural characterization of three-stranded β-sheets. This strategy can be further explored for the design of functional β-sheets.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research-Pune, Dr Homi Bhabha Road, Pune, 411 008, India. hn.gopi@iiserpune.ac.in.
authors.forename: Anupam
authors.initials: A
authors.lastname: Bandyopadhyay
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Misra
authors.forename: Hosahudya N
authors.initials: HN
authors.lastname: Gopi
mesh_terms: D003460:Crystallization; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry
chemical_list: D010455:Peptides