title: Protein homeostasis-more than resisting a hot bath.
abstract: Maintenance of protein homeostasis is essential for survival of all organisms. In bacteria, the protein quality control system has a broad physiological impact beyond heat shock resistance, being involved in virulence, antibiotic resistance, as well as protection against environmental stresses. Its contribution to rejuvenation and growth arrest suggests interference with protein quality control to be a novel antimicrobial strategy. Remarkably, a protein quality control module originating from environmental strains has been found to be horizontally transferred to predominant clonal groups of bacteria providing exquisite thermotolerance to recently emerged global pathogens suggesting that novel features related to protein homeostasis contribute to the transition to new environments.
authors.affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 77, Sweden. Electronic address: Changhan.lee@ki.se.
authors.forename: Changhan
authors.initials: C
authors.lastname: Lee
authors.affiliation: Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 171 77, Sweden.
authors.forename: Edvard
authors.initials: E
authors.lastname: Wigren
authors.affiliation: The Helmholtz Center for Infection Research, Braunschweig 38124, Germany.
authors.forename: Heinrich
authors.initials: H
authors.lastname: Lünsdorf
authors.affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 77, Sweden. Electronic address: Ute.Romling@ki.se.
authors.forename: Ute
authors.initials: U
authors.lastname: Römling
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D006706:Homeostasis; D006358:Hot Temperature
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins