title: Exogenous genistein in late gestation: effects on fetal development and sow and piglet performance.
abstract: Due to their functional similarity to estradiol, phytoestrogens could prove to be beneficial in late gestating sows. The goal of this study was to determine the impact of providing the phytoestrogen genistein during late pregnancy on the performance of sows and their litters. In total, 56 gilts were equally divided into the two following groups on day 90 of gestation: (1) controls (CTL); and (2) two daily i.m. injections of 220 mg of genistein (GEN). Treatments were carried out until farrowing. Jugular blood samples were collected from 16 gilts/treatment on days 89 and 110 of gestation, and on days 3 and 21 of lactation. Milk samples were also obtained from those sows on day 3 of lactation. A male piglet from 16 CTL and 15 GEN litters was slaughtered at 24 h postpartum and a blood sample was obtained. The liver, heart and visceral organs were weighed and the semitendinosus (ST) muscle was collected and carcass composition was determined. The treatment increased (P0.1) on weight or backfat loss of sows during lactation, milk composition or weights of piglets. The pre-weaning mortality rate of piglets was very low (0.1). However, carcasses from GEN litters contained more fat than those from CTL litters (9.63% v. 8.34%, P0.1). In conclusion, injecting gilts with 440 mg/day of genistein in late gestation increased IGF1 concentrations in gilts and carcass fat in neonatal piglets, but had minimal effect on muscle development of piglets at birth and on the performance of lactating sows and their litters.
authors.affiliation: 1Agriculture and Agri-Food Canada,Dairy and Swine Research and Development Centre,2000 College Street,Sherbrooke,QC J1M 0C8,Canada.
authors.forename: C
authors.initials: C
authors.lastname: Farmer
authors.affiliation: 2Nutrition Research Division,Health Canada,Ottawa,ON K1A 0K9,Canada.
authors.forename: P
authors.initials: P
authors.lastname: Robertson
authors.affiliation: 2Nutrition Research Division,Health Canada,Ottawa,ON K1A 0K9,Canada.
authors.forename: C W
authors.initials: CW
authors.lastname: Xiao
authors.affiliation: 3Institute of Muscle Biology and Growth,Leibniz Institute for Farm Animal Biology (FBN), D-18196Dummerstorf,Germany.
authors.forename: C
authors.initials: C
authors.lastname: Rehfeldt
authors.affiliation: 3Institute of Muscle Biology and Growth,Leibniz Institute for Farm Animal Biology (FBN), D-18196Dummerstorf,Germany.
authors.forename: C
authors.initials: C
authors.lastname: Kalbe
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D019833:Genistein / Q000008:administration & dosage*; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D008321:Mammary Glands, Animal / Q000254:growth & development; D018482:Muscle, Skeletal / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D048789:Phytoestrogens / Q000008:administration & dosage*; D034421:Sus scrofa / Q000196:embryology / Q000502:physiology*
chemical_list: D048789:Phytoestrogens; D019833:Genistein
keywords: fetal development; genistein; gestation; litter performance; sows