title: Status of research and development of vaccines for enterovirus 71.
abstract: Although outbreaks of Hand, Foot, and Mouth Disease (HFMD) in young children have long been recognized worldwide, the occurrence of rare and life-threatening neurological, respiratory, and cardiac complications has propelled this common condition into the spotlight as a major public health problem in the affected countries. Various enteroviruses cause HFMD, but the severe complications have been mostly associated with enterovirus 71 (EV71). Medical treatment is supportive and measures to interrupt transmission have been challenging to implement. Preventive vaccines could have an important clinical impact, especially among children younger than 3 years old who are most susceptible to the neurological complications. Several groups in the highly affected Asia-Pacific region are working towards vaccines against EV71 and some candidates have progressed to late-stage clinical trials with two vaccines recently reported to have been approved by the regulatory authorities in China. This report summarizes current issues and progress in the development of vaccines against EV71.
authors.affiliation: Clinical Development Consultant, 26 Rue Lecourbe, Paris 75015, France. Electronic address: zahussain22@gmail.com.
authors.forename: Zarifah
authors.initials: Z
authors.lastname: Reed
authors.affiliation: Sentinext Therapeutics, 19H Level 19, Menara Northam, 55, Jalan Sultan Ahmad Shah, 10050 George Town, Pulau Pinang, Malaysia.
authors.forename: Mary Jane
authors.initials: MJ
authors.lastname: Cardosa
mesh_terms: D035843:Biomedical Research / Q000639:trends; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D029821:Enterovirus A, Human; D006232:Hand, Foot and Mouth Disease / Q000517:prevention & control*; D006801:Humans; D014765:Viral Vaccines / Q000627:therapeutic use*
chemical_list: D014765:Viral Vaccines
keywords: Coxsackievirus A16 (CA16); EV71 vaccine; Enterovirus 71 (EV71); Hand, Foot, and Mouth Disease (HFMD); Neutralizing antibody