title: Evaluation of the Hypoglycemic Effect of Composite Rice Flour in Diabetic Mice.
abstract: To study the hypoglycemic effect of composite rice flour, the diabetic mouse model was established through the intraperitoneal injection of alloxan saline (twice, 200 mg/kg bw). The mice were randomly divided into 4 groups: negative control, positive control, metformin medication group, and composite rice flour feed group. After 21 days, the fasting blood glucose levels were determined by glucose oxidase method and followed with a glucose tolerance test. The results show that the body weight growth rate of mice in the rice flour group was significantly higher than that of the medication group (P < 0.01). Comparing with the positive control group, the fasting blood glucose levels of medication group and rice flour group were significantly lower, and the glucose tolerance was significantly increased in rice flour group (P < 0.01). In conclusion, the composite rice flour has obvious hypoglycemic and protective effect for diabetic mouse model.
authors.affiliation: Anhui Science and Technology University Institute of Food and Drug, Donghua Road No. 9, Feng-Yang Anhui, 233100, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Anhui Science and Technology University Institute of Food and Drug, Donghua Road No. 9, Feng-Yang Anhui, 233100, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Gao
authors.affiliation: Anhui Science and Technology University Institute of Food and Drug, Donghua Road No. 9, Feng-Yang Anhui, 233100, China. chuanlaidu@163.com.
authors.forename: Chuanlai
authors.initials: C
authors.lastname: Du
authors.affiliation: Minnan Normal University School of Biological Science and Biotechnology, Fujian Province Zhangzhou County Front Street No. 36, Zhangzhou Fujian, 363000, China.
authors.forename: Yimei
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Anhui Science and Technology University Institute of Food and Drug, Donghua Road No. 9, Feng-Yang Anhui, 233100, China.
authors.forename: Yuanxin
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Anhui Science and Technology University Institute of Food and Drug, Donghua Road No. 9, Feng-Yang Anhui, 233100, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Pan
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003920:Diabetes Mellitus / Q000178:diet therapy* / Q000517:prevention & control; D005260:Female; D005433:Flour; D007003:Hypoglycemia / Q000139:chemically induced*; D008297:Male; D051379:Mice; D012275:Oryza / Q000737:chemistry*; D000067348:Whole Grains
chemical_list: D001786:Blood Glucose
keywords: Composite rice; Diabetic; Glucose tolerance; Hypoglycemic