title: Effect of Growth Hormone on Endometrial Thickness and Fertility Outcome in the Treatment of Women with Panhypopituitarism: A Case Report.
abstract: BACKGROUND
  The role of growth hormone (GH) in female reproduction has become a topic of increasing interest over the last decade. The replacement of GH for ovulation induction in women with hypopituitarism remains controversial. The role of GH in the human endometrium is still largely unknown. To the best of our knowledge, this study represents the first case report showing evidence that GH might play a role not only for ovulation induction, but also for the development of endometrial thickness in women with hypopituitarism.
  
  
  METHODS
  A 32-year-old hypophysectomized. woman, known for primary infertility, experienced multiple IVF/embryo transfer failures with inadequate endometrial development. The use of GH replacement therapy followed by conventional controlled ovarian hyperstimulation enabled endometrial development and better ovarian response to gonadotropins, leading to a successful ongoing pregnancy.
  
  
  CONCLUSIONS
  The substitution with GH resulted in fewer days of ovarian stimulation, an acceptable endometrium, and a twin pregnancy delivered at 38 weeks' gestation.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Drakopoulos
authors.forename: Nicola
authors.initials: N
authors.lastname: Pluchino
authors.forename: Paul
authors.initials: P
authors.lastname: Bischof
authors.forename: Pablo
authors.initials: P
authors.lastname: Cantero
authors.forename: Patrick
authors.initials: P
authors.lastname: Meyer
authors.forename: Didier
authors.initials: D
authors.lastname: Chardonnens
mesh_terms: D000328:Adult; D004717:Endometrium / Q000187:drug effects*; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D013006:Growth Hormone