title: The Role of Steroid Sulfatase as a Prognostic Factor in Patients with Endometrial Cancer.
abstract: OBJECTIVE
  The aim of the study was to determine steroid sulfatase (STS) expression in endometrial cancer patients and its correlation with disease prognosis.
  
  
  METHODS
  We conducted a retrospective study in 59 patients who underwent surgery with histologically confirmed endometrial cancer from January 2000 to December 2011 at Hanyang University Hospital. Immuno-histochemical staining of STS was performed using rabbit polyclonal anti-STS antibody.
  
  
  RESULTS
  Sixteen of the 59 patients (27.1%) were positive for STS expression. Disease free survival (DFS) was 129.83±8.67 [95% confidence interval (CI): 112.84-146.82] months in the STS positive group (group A) and 111.06±7.17 (95% CI: 97.01-125.10) months in the STS negative group (group B) (p=0.92). Overall survival (OS) was 129.01±9.38 (95% CI: 110.63-147.38) months and 111.16±7.10 (95% CI: 97.24-125.07) months for the groups A and B, respectively (p=0.45). Univariate analysis revealed that FIGO stage and adjuvant therapy are significantly associated with DFS and OS. However, in multivariate analysis, FIGO stage and adjuvant therapy did not show any statistical significance with DFS and OS. STS was also not significantly associated with DFS and OS in univariate and multivariate analysis.
  
  
  CONCLUSIONS
  STS expression was not significantly associated with DFS and OS, despite positive STS expression in 27% of endometrial cancer patients. Therefore, the role of STS as a prognostic factor in patients with endometrial cancer remains unclear and requires further research.
authors.affiliation: Division of Gynecologic Oncology and Gynecologic Minimally Invasive Surgery, Department of Obstetrics and Gynecology, Hanyang University College of Medicine, Seoul, Korea.
authors.forename: Won Moo
authors.initials: WM
authors.lastname: Lee
authors.affiliation: Department of Pathology, Hanyang University College of Medicine, Seoul, Korea.
authors.forename: Ki-Seok
authors.initials: KS
authors.lastname: Jang
authors.affiliation: Division of Gynecologic Oncology and Gynecologic Minimally Invasive Surgery, Department of Obstetrics and Gynecology, Hanyang University College of Medicine, Seoul, Korea. obgybae@hanyang.ac.kr.
authors.forename: Jaeman
authors.initials: J
authors.lastname: Bae
authors.affiliation: Division of Gynecologic Oncology and Gynecologic Minimally Invasive Surgery, Department of Obstetrics and Gynecology, Hanyang University College of Medicine, Seoul, Korea.
authors.forename: A Ra
authors.initials: AR
authors.lastname: Koh
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D043266:Steryl-Sulfatase / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*
chemical_list: D014408:Biomarkers, Tumor; D043266:Steryl-Sulfatase
keywords: Steroid sulfatase; endometrial cancer; prognostic factor