title: Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications.
abstract: Glassy cell carcinoma of the cervix (GCCC) is a very rare and aggressive form of cervical cancer. An adolescent female with advanced metastatic disease was enrolled in our genomic profiling research protocol. We identified high-level amplification of epidermal growth factor receptor (EGFR) and Yes-associated protein-1 (YAP1), which led to the addition of EGFR inhibitors to the chemotherapy regimen. Here, we report the first genetically profiled case of GCCC with potential therapeutic implications.
authors.affiliation: 1 Integrated Cancer Genomics Division, Translational Genomics Research Institute , Phoenix, Arizona.|2 Hyundai Cancer Genomics Center, Children's Hospital of Orange County , Orange, California.
authors.forename: Troy A
authors.initials: TA
authors.lastname: McEachron
authors.affiliation: 2 Hyundai Cancer Genomics Center, Children's Hospital of Orange County , Orange, California.|3 Division of Hematology-Oncology, Department of Medicine, School of Medicine, University of California-Irvine , Orange, California.|4 Department of Epidemiology, School of Medicine, University of California-Irvine , Orange, California.|5 Department of Pediatrics, School of Medicine, University of California-Irvine , Orange, California.
authors.forename: Leonard S
authors.initials: LS
authors.lastname: Sender
authors.affiliation: 2 Hyundai Cancer Genomics Center, Children's Hospital of Orange County , Orange, California.|3 Division of Hematology-Oncology, Department of Medicine, School of Medicine, University of California-Irvine , Orange, California.
authors.forename: Keri B
authors.initials: KB
authors.lastname: Zabokrtsky
authors.affiliation: 6 Marian University Osteopathic Medical School , Indianapolis, Indiana.
authors.forename: Brian
authors.initials: B
authors.lastname: Kaltenecker
authors.affiliation: 7 Department of Radiology, Children's Hospital of Orange County , Orange, California.
authors.forename: W Nathan
authors.initials: WN
authors.lastname: Holmes
authors.affiliation: 1 Integrated Cancer Genomics Division, Translational Genomics Research Institute , Phoenix, Arizona.
authors.forename: Irene
authors.initials: I
authors.lastname: Cherni
authors.affiliation: 1 Integrated Cancer Genomics Division, Translational Genomics Research Institute , Phoenix, Arizona.
authors.forename: Zarko
authors.initials: Z
authors.lastname: Manojlovic
authors.affiliation: 8 Department of Pathology, Children's Hospital of Orange County , Orange, California.|9 Department of Pathology, School of Medicine, University of California-Irvine , Orange, California.
authors.forename: Shu-Yuan
authors.initials: SY
authors.lastname: Liao
authors.affiliation: 10 Neurogenomics Division, Translational Genomics Research Institute , Phoenix, Arizona.
authors.forename: David W
authors.initials: DW
authors.lastname: Craig
authors.affiliation: 1 Integrated Cancer Genomics Division, Translational Genomics Research Institute , Phoenix, Arizona.
authors.forename: John D
authors.initials: JD
authors.lastname: Carpten
authors.affiliation: 2 Hyundai Cancer Genomics Center, Children's Hospital of Orange County , Orange, California.|5 Department of Pediatrics, School of Medicine, University of California-Irvine , Orange, California.
authors.forename: Lilibeth R
authors.initials: LR
authors.lastname: Torno
mesh_terms: D000293:Adolescent; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: carcinoma; cervical cancer; chemotherapy; gene regulation; imaging; treatment