title: [A comparative study between propofol and etomidate in patients under general anesthesia].
abstract: OBJECTIVE
  Induction of anesthesia is a critical part of anesthesia practice. Sudden hypotension, arrhythmias, and cardiovascular collapse are threatening complications following injection of induction agent in hemodynamically unstable patients. It is desirable to use a safe agent with fewer adverse effects for this purpose. Present prospective randomized study is designed to compare propofol and etomidate for their effect on hemodynamics and various adverse effects on patients in general anesthesia.
  
  
  METHODS
  Hundred ASA I and II patients of age group 18-60 years scheduled for elective surgical procedure under general anesthesia were randomly divided into two groups of 50 each receiving propofol (2mg/kg) and etomidate (0.3mg/kg) as an induction agent. Vital parameters at induction, laryngoscopy and thereafter recorded for comparison. Adverse effect viz. pain on injection, apnea and myoclonus were carefully watched.
  
  
  RESULTS
  Demographic variables were comparable in both the groups. Patients in etomidate group showed little change in mean arterial pressure (MAP) and heart rate (HR) compared to propofol (p>0.05) from baseline value. Pain on injection was more in propofol group while myoclonus activity was higher in etomidate group.
  
  
  CONCLUSIONS
  This study concludes that etomidate is a better agent for induction than propofol in view of hemodynamic stability and less pain on injection.
authors.affiliation: Departamento de Anestesiologia e Tratamento Intensivo, Faculdade de Medicina e Hospital Mahatma Gandhi, Jaipur, Rajasthan, Índia.
authors.forename: Supriya
authors.initials: S
authors.lastname: Aggarwal
authors.affiliation: Departamento de Anestesiologia e Tratamento Intensivo, Faculdade de Medicina e Hospital Mahatma Gandhi, Jaipur, Rajasthan, Índia. Electronic address: dr.vipin28@gmail.com.
authors.forename: Vipin Kumar
authors.initials: VK
authors.lastname: Goyal
authors.affiliation: Departamento de Anestesiologia e Tratamento Intensivo, Faculdade de Medicina e Hospital Mahatma Gandhi, Jaipur, Rajasthan, Índia.
authors.forename: Shashi Kala
authors.initials: SK
authors.lastname: Chaturvedi
authors.affiliation: Departamento de Anestesiologia e Tratamento Intensivo, Faculdade de Medicina e Hospital Mahatma Gandhi, Jaipur, Rajasthan, Índia.
authors.forename: Vijay
authors.initials: V
authors.lastname: Mathur
authors.affiliation: Departamento de Anestesiologia e Tratamento Intensivo, Faculdade de Medicina e Hospital Mahatma Gandhi, Jaipur, Rajasthan, Índia.
authors.forename: Birbal
authors.initials: B
authors.lastname: Baj
authors.affiliation: Departamento de Anestesiologia e Tratamento Intensivo, Faculdade de Medicina e Hospital Mahatma Gandhi, Jaipur, Rajasthan, Índia.
authors.forename: Alok
authors.initials: A
authors.lastname: Kumar
keywords: Estabilidade hemodinâmica; Hemodynamic stability; Induction of anesthesia; Indução da anestesia; Mean arterial pressure; Mioclonia; Myoclonus; Pressão arterial média; Propofol