title: Asymmetric Retro-Claisen Reaction by Chiral Primary Amine Catalysis.
abstract: The communication describes an enamine-based asymmetric retro-Claisen reaction of β-diketones by primary amine catalysis. The reaction proceeds via a sequence of stereoselective C-C formation, C-C cleavage, and a highly stereospecific enamine protonation to afford chiral α-alkylated ketones or macrolides with high yields and enantioselectivities. A detailed mechanism was explored on the basis of experimental evidence and computational studies to account for the observed stereocontrol.
authors.affiliation: Beijing National Laboratory for Molecule Sciences (BNLMS), CAS Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|Collaborative Innovation Center of Chemical Science and Engineering , Tianjin 300071, China.
authors.forename: Yunbo
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Beijing National Laboratory for Molecule Sciences (BNLMS), CAS Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|Collaborative Innovation Center of Chemical Science and Engineering , Tianjin 300071, China.
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Beijing National Laboratory for Molecule Sciences (BNLMS), CAS Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|Collaborative Innovation Center of Chemical Science and Engineering , Tianjin 300071, China.
authors.forename: Sanzhong
authors.initials: S
authors.lastname: Luo