title: Organizers in Development.
abstract: An "organizer" is formally defined as a region, or group of cells in an embryo that can both induce (change the fate) and pattern (generate an organized set of structures) adjacent embryonic cells. To date, about four such regions have been demonstrated: the primary or Spemann organizer (Hensen's node in amniotes), the notochord, the zone of polarizing activity of the limb bud, and the mid-hindbrain boundary. Here we review the evidence for these and compare them with a few other regions which have been proposed to represent other organizers and we speculate on why so few such regions have been discovered.
authors.affiliation: Department of Cell & Developmental Biology, University College London, London, United Kingdom.
authors.forename: Claire
authors.initials: C
authors.lastname: Anderson
authors.affiliation: Department of Cell & Developmental Biology, University College London, London, United Kingdom. Electronic address: c.stern@ucl.ac.uk.
authors.forename: Claudio D
authors.initials: CD
authors.lastname: Stern
mesh_terms: D000818:Animals; D016764:Cell Polarity; D004622:Embryo, Mammalian / Q000166:cytology*; D006801:Humans; D009672:Notochord / Q000166:cytology*; D020897:Organizers, Embryonic / Q000166:cytology*
keywords: Floor plate induction; Hensen's node; Neural induction; Notochord; Patterning; Primary organizer; Secondary organizers; Signaling; Spemann–Mangold organizer; Zone of polarizing activity