title: Calculation of Blood Dose in Patients Treated With 131I Using MIRD, Imaging, and Blood Sampling Methods.
abstract: Radioiodine therapy is known as the most effective treatment of differentiated thyroid carcinoma (DTC) to ablate remnant thyroid tissue after surgery. In patients with DTC treated with radioiodine, internal radiation dosimetry of radioiodine is useful for radiation risk assessment. The aim of this study is to describe a method to estimate the absorbed dose to the blood using medical internal radiation dosimetry methods. In this study, 23 patients with DTC with different administrated activities, 3.7, 4.62, and 5.55 GBq after thyroidectomy, were randomly selected. Blood dosimetry of treated patients was performed with external whole body counting using a dual-head gamma camera imaging device and also with blood sample activity measurements using a dose calibrator. Absorbed dose to the blood was measured at 2, 6, 12, 24, 48, and 96 hours after the administration of radioiodine with the 2 methods. Based on the results of whole body counting and blood sample activity dose rate measurements, 96 hours after administration of 3.7, 4.62, and 5.55 GBq of radioiodine, absorbed doses to patients' blood were 0.65 ± 0.20, 0.67 ± 0.18, 0.79 ± 0.51 Gy, respectively. Increasing radioiodine activity from 3.7 to 5.55 GBq increased blood dose significantly, while there was no significant difference in blood dose between radioiodine dosages of 3.7 and 4.62 GBq. Our results revealed a significant correlation between the blood absorbed dose and blood sample activity and between the blood absorbed dose and whole body counts 24 to 48 hours after the administration of radioiodine.
authors.affiliation: From the Nuclear Medicine and Molecular Imaging Research Center (EP, MH, SME), Namazi Teaching Hospital, Shiraz University of Medical Sciences; Ray Medical Engineering Department (EP, RF), Shiraz University, Shiraz, Iran; Radiation Research Center (RF), Shiraz University, Shiraz, Iran; and Radiation Medicine Engineering Department (SME), Shahid Beheshti University, GC, Tehran, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Piruzan
authors.forename: Mahdi
authors.initials: M
authors.lastname: Haghighatafshar
authors.forename: Reza
authors.initials: R
authors.lastname: Faghihi
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Entezarmahdi
mesh_terms: D065638:Absorption, Radiation; D000328:Adult; D002277:Carcinoma / Q000097:blood* / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods; D018714:Radiotherapy, Adjuvant; D011897:Random Allocation; D013964:Thyroid Neoplasms / Q000097:blood* / Q000532:radiotherapy* / Q000601:surgery; D013997:Time Factors; D014915:Whole-Body Counting / Q000379:methods
chemical_list: D007457:Iodine Radioisotopes