title: Clinical significance of diabetes mellitus on detrusor functionality on stress urinary incontinent women without bladder outlet obstruction.
abstract: OBJECTIVE
  Our aim was to evaluate the effect of diabetes mellitus (DM) on detrusor contractility (DC) in women without bladder outlet obstruction (BOO) by using urodynamic study (UDS).
  
  
  METHODS
  We reviewed the clinical records of 863 consecutive women without BOO, each of whom was diagnosed with stress urinary incontinence (SUI) by UDS. Uroflowmetry measurements included maximal flow rate (Qmax), time to Qmax, voided volume, and postvoid residual urine volume (PVR). Data from filling cystometry included the first strong desire to void and the Valsalva leak-point pressure (VLPP). For voiding cystometry data, detrusor pressure at Qmax (Pdet@Qmax) and bladder contractility index (BCI) were analyzed. In the DM group, the level of glycosylated hemoglobin (HbA1c) and DM duration were measured.
  
  
  RESULTS
  After the application of exclusion criteria, complete UDS data of 708 patients were available. The cohort was divided into two groups according to DM status. The DM group comprised 92 (12.9 %) patients, the non-DM group 616 (87.0 %). Mean maximal flow rate and Pdet@Qmax and bladder contractility index were lower in the DM group, in whom mean DM duration was 9.24 ± 7.63 years and mean HbA1c level 7.27 ± 1.43 %. DM duration was significantly correlated with Qmax (-0.309, p = 0.003), Pdet@Qmax (-0.369, p < 0.001), and BCI (-0.409, p < 0.001). Moreover, the HbA1c level was significantly correlated with Qmax (-0.256, p = 0.016), Pdet@Qmax (-0.231, p = 0.026), and BCI (-0.308, p = 0.002).
  
  
  CONCLUSIONS
  Our UDS data revealed that DM is associated with impaired DC in women without BOO. Moreover, longer DM duration and poor glycemic control were associated with impaired DC.
authors.affiliation: Department of Urology, Chonbuk National University Medical School, and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, 561-712, South Korea.
authors.forename: Yu Seob
authors.initials: YS
authors.lastname: Shin
authors.affiliation: Department of Urology, Chonbuk National University Medical School, and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, 561-712, South Korea.
authors.forename: Ji Won
authors.initials: JW
authors.lastname: On
authors.affiliation: Department of Urology, Chonbuk National University Medical School, and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, 561-712, South Korea. mkkim@jbnu.ac.kr.
authors.forename: Myung Ki
authors.initials: MK
authors.lastname: Kim
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009119:Muscle Contraction; D012189:Retrospective Studies; D001748:Urinary Bladder Neck Obstruction / Q000150:complications*; D053201:Urinary Bladder, Overactive / Q000150:complications*; D014550:Urinary Incontinence, Stress / Q000150:complications*; D014554:Urination / Q000502:physiology*
keywords: Diabetes mellitus; LUTS; Urodynamics