title: Plasma Endocan Levels in Patients With Isolated Coronary Artery Ectasia.
abstract: Endocan is a soluble proteoglycan, secreted by human vascular endothelial cells. Endocan is a marker for vascular pathologies and an important mediator of angiogenesis, strongly associated with inflammation, vascular endothelial dysfunction, and atherosclerosis. The relationship between coronary artery ectasia (CAE) and endocan has not been evaluated. We aimed to investigate this association. Fifty-four patients with isolated CAE without coronary stenosis and 30 controls with normal coronary angiogram were included in this study. Endocan plasma concentrations were measured using an enzyme-linked immunosorbent assay. Patients with isolated CAE had significantly higher levels of endocan compared to the controls (18.9 ± 7.3 vs 15.6 ± 3.6 ng/mL; P = .007). There was a significant correlation between endocan levels and severity of isolated CAE according to the Markis classification ( r = -.593, P < .001). Plasma endocan levels may reflect the presence and severity of isolated CAE, suggesting that endocan may be involved in pathogenesis of isolated CAE.
authors.affiliation: 1 Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Turhan
authors.initials: T
authors.lastname: Turan
authors.affiliation: 1 Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Ali Riza
authors.initials: AR
authors.lastname: Akyuz
authors.affiliation: 1 Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Ahmet Cagri
authors.initials: AC
authors.lastname: Aykan
authors.affiliation: 1 Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Kul
authors.affiliation: 1 Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Cirakoglu
authors.affiliation: 1 Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Ahmet Oguz
authors.initials: AO
authors.lastname: Aslan
authors.affiliation: 2 Department of Cardiology, Izmir Sifa University Hospital, Trabzon, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Gul
authors.affiliation: 3 Department of Clinical Biochemistry, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Utku
authors.initials: U
authors.lastname: Uçar
authors.affiliation: 4 Department of Nutrition and Dietetics, Faculty of Health Science, Karadeniz Technical University Trabzon, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Demir
authors.affiliation: 1 Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Sukru
authors.initials: S
authors.lastname: Celik
mesh_terms: D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D004108:Dilatation, Pathologic / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D011446:Prospective Studies; D011509:Proteoglycans / Q000097:blood*; D012016:Reference Values; D013223:Statistics as Topic
chemical_list: C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans
keywords: endocan (ESM-1); endothelium; inflammation; isolated coronary ectasia