title: PAH metabolites in fish bile: From the Seine estuary to Iceland.
abstract: Polycyclic aromatic hydrocarbons (PAH) are environmental contaminants that pose significant risk to health of fish. The International Workshop on Integrated Assessment of Contaminant Impacts on the North Sea (ICON) provided the framework to investigate biomarker responses as well as contaminant concentrations side by side in marine ecosystems. Concentrations of the main PAH metabolites 1-hydroxypyrene, 1-hydroxyphenanthren and 3-hydroxybenzo(a)pyrene were determined in bile by HPLC with fluorescence detection. Fish species under investigation were dab (Limanda limanda), flounder (Platichthys flesus) and haddock (Melanogrammus aeglefinus). A contamination gradient was demonstrated from the low contaminated waters of Iceland and off-shore regions of the North Sea towards higher concentrations in coastal areas. Concentrations of PAH metabolites differed primarily according to sampling region and secondarily to species.
authors.affiliation: Thünen Institut of Fisheries Ecology, Palmaille 9, D-22767, Hamburg & Deichstr. 12, 27472 Cuxhaven, Germany. Electronic address: ulrike.kammann@thuenen.de.
authors.forename: U
authors.initials: U
authors.lastname: Kammann
authors.affiliation: Ifremer, Department of Biogeochemistry and Ecotoxicology, BP 21105, 44311 Nantes Cedex 03, France.
authors.forename: F
authors.initials: F
authors.lastname: Akcha
authors.affiliation: Université Bordeaux 1, Laboratory of Physico- and Toxico-Chemistry of the Environment (LPTC), Molecular Sciences Institute (ISM), UMR 5255 CNRS, 33405 Talence, France.
authors.forename: H
authors.initials: H
authors.lastname: Budzinski
authors.affiliation: Ifremer, Department of Biogeochemistry and Ecotoxicology, BP 21105, 44311 Nantes Cedex 03, France.
authors.forename: T
authors.initials: T
authors.lastname: Burgeot
authors.affiliation: FRS Marine Laboratory, 375 Victoria Road, Aberdeen, AB11 9DB Scotland, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gubbins
authors.affiliation: Thünen Institut of Fisheries Ecology, Palmaille 9, D-22767, Hamburg & Deichstr. 12, 27472 Cuxhaven, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Lang
authors.affiliation: Université Bordeaux 1, Laboratory of Physico- and Toxico-Chemistry of the Environment (LPTC), Molecular Sciences Institute (ISM), UMR 5255 CNRS, 33405 Talence, France.
authors.forename: K
authors.initials: K
authors.lastname: Le Menach
authors.affiliation: Institute for Environmental Studies (IVM), VU University Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands.
authors.forename: A D
authors.initials: AD
authors.lastname: Vethaak
authors.affiliation: Department of Biology, University of Oslo, Pb 1066, Blindern, N-0316 Oslo, Norway; Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, N-0349 Oslo, Norway.
authors.forename: K
authors.initials: K
authors.lastname: Hylland
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D004784:Environmental Monitoring; D063366:Estuaries; D005399:Fishes / Q000378:metabolism*; D007055:Iceland; D011084:Polycyclic Aromatic Hydrocarbons / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D011084:Polycyclic Aromatic Hydrocarbons; D014874:Water Pollutants, Chemical
keywords: Atlantic; Dab; Flounder; Haddock; Marine monitoring; North Sea; PAH metabolite