title: Relationships between maximal strength, muscle size, and myosin heavy chain isoform composition and postactivation potentiation.
abstract: The purpose of this study was to examine the relationships between maximal voluntary postactivation potentiation (PAP) and maximal knee extensor torque, quadriceps cross-sectional area (CSA) and volume, and type II myosin heavy chain (MHC) isoform percentage in human skeletal muscle. Thirteen resistance-trained men completed a test protocol consisting of 2 isokinetic knee extensions at 180°·s(-)(1) performed before and 1, 4, 7, and 10 min after the completion of 4 maximal knee extensions at 60°·s(-)(1) (i.e., a conditioning activity (CA)). Magnetic resonance imaging and muscle microbiopsy procedures were completed on separate days to assess quadriceps CSA and volume and MHC isoform content. Maximal voluntary PAP response was assessed as the ratio of the highest knee extensor torques measured before and after the CA. There were large to very large correlations between maximal voluntary PAP response and maximal knee extensor torque (r = 0.62) and quadriceps CSA (r = 0.68) and volume (r = 0.63). Nonetheless, these correlations were not statistically significant after adjusting for the influence of type II MHC percentage using partial correlation analysis. By contrast, the strongest correlation was observed for type II MHC percentage (r = 0.77), and this correlation remained significant after adjusting for the other variables. Maximal voluntary PAP response is strongly correlated with maximal knee extensor torque and quadriceps CSA and volume, but is mostly clearly associated with the type II myosin isoform percentage in human skeletal muscle.
authors.affiliation: a Centre for Exercise and Sport Science Research, Edith Cowan University, Joondalup, WA 6027, Australia.
authors.forename: Laurent B
authors.initials: LB
authors.lastname: Seitz
authors.affiliation: a Centre for Exercise and Sport Science Research, Edith Cowan University, Joondalup, WA 6027, Australia.|b School of Exercise Science, Sport and Health, Charles Sturt University, Bathurst, NSW 2795, Australia.
authors.forename: Gabriel S
authors.initials: GS
authors.lastname: Trajano
authors.affiliation: a Centre for Exercise and Sport Science Research, Edith Cowan University, Joondalup, WA 6027, Australia.
authors.forename: G Gregory
authors.initials: GG
authors.lastname: Haff
authors.affiliation: c Department of Health and Human Performance, University of Montana, Missoula, MT 59812, USA.
authors.forename: Charles C L S
authors.initials: CC
authors.lastname: Dumke
authors.affiliation: a Centre for Exercise and Sport Science Research, Edith Cowan University, Joondalup, WA 6027, Australia.
authors.forename: James J
authors.initials: JJ
authors.lastname: Tufano
authors.affiliation: a Centre for Exercise and Sport Science Research, Edith Cowan University, Joondalup, WA 6027, Australia.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Blazevich
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015444:Exercise; D006801:Humans; D007717:Knee / Q000502:physiology; D007719:Knee Joint / Q000502:physiology; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000502:physiology*; D018995:Myosin Heavy Chains / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D055070:Resistance Training; D019415:Torque; D055815:Young Adult
chemical_list: D020033:Protein Isoforms; D018995:Myosin Heavy Chains
keywords: conditioning activity; fibre type; isoformes de myosine; moment de force; muscle size; muscle torque; myosin isoform; postactivation potentiation; potentialisation musculaire; stimulus conditionnant; typologie musculaire; volume musculaire