title: [Gliomas – What I Have to Know in ten Questions].
abstract: Gliomas are the most common primary tumors involving the central nervous system. They can manifest with diverse and non-specific general and neurological symptoms. The diagnostic gold standard is cerebral magnetic resonance imaging and subsequent histological confirmation of the diagnosis. Steroids, especially dexamethasone, are used in case of focal symptoms and of symptoms caused by increased intracranial pressure, and antiepileptic drugs are used to manage epileptic seizures. Non-enzyme-inducing antiepileptic drugs are preferable. Glioma patients have an inherently elevated thromboembolic risk, and therapeutic anticoagulation is indicated following a thromboembolic event. Surgery, radiotherapy and systemic therapy are used as tumor-specific therapy modalities in gliomas. Molecular markers play an increasing role in the prognosis and selection of therapy in daily oncological routine.
authors.affiliation: 1 Hirntumorzentrum, Universitätsspital Zürich.|2 Kliniken für Onkologie, Universitätsspital Zürich.
authors.forename: Wiebke
authors.initials: W
authors.lastname: Gulden-Sala
authors.affiliation: 1 Hirntumorzentrum, Universitätsspital Zürich.|3 Neurologie, Universitätsspital Zürich.
authors.forename: Patrick
authors.initials: P
authors.lastname: Roth
authors.affiliation: 1 Hirntumorzentrum, Universitätsspital Zürich.|4 Radio-Onkologie, Universitätsspital Zürich.
authors.forename: Michelle
authors.initials: M
authors.lastname: Brown
authors.affiliation: 1 Hirntumorzentrum, Universitätsspital Zürich.|4 Radio-Onkologie, Universitätsspital Zürich.
authors.forename: Nicolaus
authors.initials: N
authors.lastname: Andratschke
authors.affiliation: 1 Hirntumorzentrum, Universitätsspital Zürich.|3 Neurologie, Universitätsspital Zürich.
authors.forename: Michael
authors.initials: M
authors.lastname: Weller
authors.affiliation: 1 Hirntumorzentrum, Universitätsspital Zürich.|2 Kliniken für Onkologie, Universitätsspital Zürich.
authors.forename: Roger
authors.initials: R
authors.lastname: Stupp
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D003131:Combined Modality Therapy / Q000009:adverse effects / Q000379:methods; D003907:Dexamethasone / Q000009:adverse effects / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005909:Glioblastoma / Q000175:diagnosis* / Q000188:drug therapy; D005910:Glioma / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009837:Oligodendroglioma / Q000175:diagnosis* / Q000188:drug therapy; D049268:Positron-Emission Tomography; D014443:Tyrosine / Q000031:analogs & derivatives
chemical_list: D000925:Anticoagulants; D000927:Anticonvulsants; C545932:(18F)fluoroethyltyrosine; D014443:Tyrosine; D003907:Dexamethasone
keywords: Antiepileptika; Glioblastom; Oligodendrogliom; Steroide; Thrombose; antiepileptics; antiépileptique; glioblastoma; glioblastome; oligodendroglioma; oligodendrogliome; steroids; stéroides; thrombose; thrombosis