title: Interactions between maternal killer cell immunoglobulin receptor genes and foetal HLA ligand genes contribute to type 1 diabetes susceptibility in Han Chinese.
abstract: In this study, we aimed to test the hypothesis that KIR haplotypes (that interact with HLA class I molecules) are associated with susceptibility in patients with T1DM in utero through maternal-foetal interaction of KIR and their HLA class I ligands in Han Chinese population. We determined the KIR genes and KIR/ligand gene combination frequencies in 59 Han Chinese children with T1D and their mothers and compared it with 159 healthy control children and their mothers. The absence of KIR-2DS1 in the mother and the presence of HLA-C2 ligand in the child were negatively associated with type 1 diabetes in the child. Our results indicate that maternal KIR genes and their interaction with foetal HLA-C2 may contribute to the risk of type 1 diabetes among Han Chinese children.
authors.affiliation: Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.|Department of Pediatric Endocrinology and Inborn Metabolic diseases, Children's Hospital of Fudan University, Shanghai, China.
authors.forename: C
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Sanjeevi
authors.affiliation: Department of Pediatric Endocrinology and Inborn Metabolic diseases, Children's Hospital of Fudan University, Shanghai, China.
authors.forename: F
authors.initials: F
authors.lastname: Luo
authors.affiliation: Department of Pediatric Endocrinology and Inborn Metabolic diseases, Children's Hospital of Fudan University, Shanghai, China.
authors.forename: D
authors.initials: D
authors.lastname: Zhi
authors.affiliation: Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.
authors.forename: C B
authors.initials: CB
authors.lastname: Sanjeevi
mesh_terms: D000328:Adult; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes / Q000235:genetics; D054502:Histocompatibility, Maternal-Fetal / Q000235:genetics; D006801:Humans; D008024:Ligands; D008297:Male; D054340:Receptors, KIR / Q000235:genetics* / Q000276:immunology
chemical_list: D015236:HLA-C Antigens; C496212:KIR2DS1 protein, human; D008024:Ligands; D054340:Receptors, KIR