title: Acrokeratoelastoidosis.
abstract: Acrokeratoelastoidosis is a rare palmoplantar keratoderma. We report the case of a 32-year old man with multiple keratotic papules and plaques on the peripheral margins of his hands and feet. Histopathologic evaluation showed compact orthokeratosis; Verhoeff van Gieson stain showed thin and fragmented elastic fibers. The differential diagnosis includes focal acral hyperkeratosis, which has a similar presentation but with normal elastic fibers. Treatment of acrokeratoelastoidosis is often disappointing, with minimal response to topical glucocorticoids, keratolytics, retinoids, cryotherapy, and lasers.
authors.affiliation: New York University School of Medicine.
authors.forename: Euphemia W
authors.initials: EW
authors.lastname: Mu
authors.forename: Adnan
authors.initials: A
authors.lastname: Mir
authors.forename: Shane A
authors.initials: SA
authors.lastname: Meehan
authors.forename: Nathalie
authors.initials: N
authors.lastname: Nguyen
mesh_terms: D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005528:Foot; D006225:Hand; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000473:pathology*; D008297:Male; D012867:Skin / Q000473:pathology*