title: Graves' Patient with Thymic Expression of Thyrotropin Receptors and Dynamic Changes in Thymic Hyperplasia Proportional to Graves' Disease Activity.
abstract: Thymic hyperplasia is frequently observed in Graves' disease. However, detectable massive enlargement of the thymus is rare, and the mechanism of its formation has remained elusive. This case showed dynamic changes in thymic hyperplasia on serial computed tomography images consistent with changes in serum thyrotropin receptor (TSH-R) antibodies and thyroid hormone levels. Furthermore, the patient's thymic tissues underwent immunohistochemical staining for TSH-R, which demonstrated the presence of thymic TSH-R. The correlation between serum TSH-R antibody levels and thymic hyperplasia sizes and the presence of TSH-R in her thymus suggest that TSH-R antibodies could have a pathogenic role in thymic hyperplasia.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Young Shin
authors.initials: YS
authors.lastname: Song
authors.affiliation: Department of Pathology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Jae-Kyung
authors.initials: JK
authors.lastname: Won
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.|Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University, Seoul, Korea.
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Dong-Wan
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.|Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University, Seoul, Korea.
authors.forename: June-Key
authors.initials: JK
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Do Joon
authors.initials: do J
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea. yjparkmd@snu.ac.kr.
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Park
mesh_terms: D000328:Adult; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000601:surgery / Q000628:therapy; D006801:Humans; D008297:Male; D011989:Receptors, Thyrotropin / Q000097:blood; D013950:Thymus Gland / Q000000981:diagnostic imaging; D013952:Thymus Hyperplasia / Q000000981:diagnostic imaging* / Q000209:etiology / Q000276:immunology; D013963:Thyroid Hormones; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D011989:Receptors, Thyrotropin; D013963:Thyroid Hormones; D013972:Thyrotropin
keywords: Thymus hyperplasia; graves disease; immunoglobulins, thyroid-stimulating; receptors thyrotropin