title: Understanding Celiac Disease by Genomics.
abstract: Celiac disease (CeD) is a complex immune-mediated disease. Genetic studies have implicated 43 predisposing loci that collectively explain some 50% of the genetic variance in CeD. More than ∼90% of CeD-associated single nucleotide polymorphisms (SNPs) localize to the non-coding genome, which we need to better understand to translate genetic knowledge into clinical practice. New genomic technologies and resources are permitting a systematic analysis of the functional elements in the non-coding part of the genome. Here we explain how investigating the regulatory and epigenomic landscape will help to pinpoint the cell types involved in CeD, and the driver genes and gene regulatory networks that are affected by CeD-associated SNPs.
authors.affiliation: University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands. Electronic address: s.withoff@umcg.nl.
authors.forename: Sebo
authors.initials: S
authors.lastname: Withoff
authors.affiliation: University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
authors.forename: Iris
authors.initials: I
authors.lastname: Jonkers
authors.affiliation: University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
authors.forename: Cisca
authors.initials: C
authors.lastname: Wijmenga
mesh_terms: D002446:Celiac Disease / Q000235:genetics* / Q000503:physiopathology; D053263:Gene Regulatory Networks / Q000235:genetics*; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D020641:Polymorphism, Single Nucleotide
keywords: autoimmune disease; celiac disease; complex genetics; enhancer; epigenetics; non-coding genome