title: [Prognostic significance of serum gamma-glutamyl transferase before transcatheter arterial chemoembolization in patients with hepatitis C virus-related hepatocellular carcinoma].
abstract: OBJECTIVE
  To evaluate the prognostic significance of serum GGT in patients with hepatitis C virus-related hepatocellular carcinoma (HCV-HCC) treated with transcatheeter arterial chemoembolization (TACE).
  
  
  METHODS
  The clinicopathological data of 110 patients with hepatitis C virus-related stage B hepatocellular carcinoma, who received TACE treatment from January 2008 to May 2011, were retrospectively analyzed. The patients were divided into two groups: the normal GCT group (GGT<50 U/L, 41 cases) and high GCT group (GGT≥50 U/L, 69 cases). The Kaplan-Meier method was used to analyze the survival rates, log-rank test was used for univariate analysis, and Cox regression model was used for multivariate analysis. The factors affecting survival and prognosis of the patients were analyzed.
  
  
  RESULTS
  The pretreatment GGT level was (160.0±120.2) U/L in the high GGT group and (40.1±8.5) U/L in the normal GGT group (P<0.001). After TACE treatment, the 1-, 2- and 3-year survival rates were 90.2%, 45.9% and 24.6% in the high GGT group, and 90.2%, 75.6% and 58.5%, respectively, in the normal GGT group (P=0.002). The univariate analysis showed that the pretreatment GGT level, ECOG score, α-fetoprotein, tumor size, tumor number, and Child grade are factors affecting the prognosis of HCV-related hepatocellular carcinoma patients (P<0.05 for all). The Cox multivariate survival analysis revealed that the tumor size, tumor number, Child grade, and serum GGT level are independent prognostic factors for patients with stage B HCV-related hepatocellular carcinoma.
  
  
  CONCLUSIONS
  The level of serum GGT before TACE is an independent prognostic factor for patients with stage B HCV-related hepatocellular carcinoma.
authors.affiliation: Department of Traditional Chinese Medicine, Beijing Shijingshan Hospital, Shijingshan Teaching Hospital of Capital Medical University, Beijing 100043, China.
authors.forename: Z F
authors.initials: ZF
authors.lastname: Chang
authors.affiliation: Department of Interventional Radiology, General Hospital of Chinese PLA, Medical College of Chinese PLA, Beijing 100853, China.
authors.forename: F Y
authors.initials: FY
authors.lastname: Liu
authors.affiliation: Department of Interventional Radiology, General Hospital of Chinese PLA, Medical College of Chinese PLA, Beijing 100853, China.
authors.forename: F
authors.initials: F
authors.lastname: Duan
authors.affiliation: Department of Interventional Radiology, General Hospital of Chinese PLA, Medical College of Chinese PLA, Beijing 100853, China.
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Wang
authors.affiliation: Department of Interventional Radiology, General Hospital of Chinese PLA, Medical College of Chinese PLA, Beijing 100853, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Yan
authors.affiliation: Department of Interventional Radiology, General Hospital of Chinese PLA, Medical College of Chinese PLA, Beijing 100853, China.
authors.forename: M Q
authors.initials: MQ
authors.lastname: Wang
mesh_terms: D000704:Analysis of Variance; D006528:Carcinoma, Hepatocellular / Q000201:enzymology* / Q000473:pathology / Q000628:therapy* / Q000821:virology; D016461:Chemoembolization, Therapeutic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000201:enzymology* / Q000628:therapy* / Q000821:virology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D047368:Tumor Burden; D000509:alpha-Fetoproteins / Q000032:analysis; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D000509:alpha-Fetoproteins; D005723:gamma-Glutamyltransferase