title: The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans.
abstract: Food-derived bioactive peptides may have various physiological modulatory and regulatory functions and are now being studied extensively. Recently, the novel dipeptide Tyr-Ala was isolated from hydrolyzed maize protein. Tyr-Ala significantly prolonged the lifespan of wild-type Caenorhabditis elegans and extended the nematode healthspan and lifespan during heat/oxidative stress. Compared with its constituent amino acids, Tyr-Ala was more efficient in enhancing stress resistance. Further studies demonstrated that the significant longevity-extending effects of Tyr-Ala on Caenorhabditis elegans were attributed to its in vitro and in vivo free radical-scavenging effects, in addition to its ability to up-regulate stress resistance-related proteins, such as SOD (Superoxide Dismutase)-3 and HSP (Heat Shock Protein)-16.2. Real-time PCR results showed that the up-regulation of aging-associated genes, such as daf-16, sod-3, hsp-16.2 and skn-1, also contributed to the stress-resistance effect of Tyr-Ala. These results indicate that the novel dipeptide Tyr-Ala can protect against external stress and thus extend the lifespan and healthspan of Caenorhabditis elegans. Thereby, Tyr-Ala could be used as a potential medicine in anti-aging research.
authors.affiliation: Key laboratory for Molecular Enzymology and Engineering, the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China. guoyi@jlu.edu.cn xuli@jlu.edu.cn.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Food Sciences and Technology, Harbin Institute of Technology at Weihai, 264209, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Jilin Province People's Hospital, Changchun 130021, China.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key laboratory for Molecular Enzymology and Engineering, the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China. guoyi@jlu.edu.cn xuli@jlu.edu.cn.
authors.forename: R
authors.initials: R
authors.lastname: Lin
authors.affiliation: Key laboratory for Molecular Enzymology and Engineering, the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China. guoyi@jlu.edu.cn xuli@jlu.edu.cn.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key laboratory for Molecular Enzymology and Engineering, the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China. guoyi@jlu.edu.cn xuli@jlu.edu.cn.
authors.forename: H
authors.initials: H
authors.lastname: Ma
authors.affiliation: Key laboratory for Molecular Enzymology and Engineering, the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China. guoyi@jlu.edu.cn xuli@jlu.edu.cn.
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Key laboratory for Molecular Enzymology and Engineering, the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China. guoyi@jlu.edu.cn xuli@jlu.edu.cn.
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. zhaobl@sun5.ibp.ac.cn.
authors.forename: B
authors.initials: B
authors.lastname: Zhao
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D004151:Dipeptides / Q000008:administration & dosage*; D006801:Humans; D008136:Longevity / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010940:Plant Proteins / Q000008:administration & dosage* / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism; D003313:Zea mays / Q000737:chemistry*
chemical_list: D029742:Caenorhabditis elegans Proteins; D004151:Dipeptides; D010940:Plant Proteins; C016968:alanyltyrosine; D013482:Superoxide Dismutase