title: Self-assembly of a 5-fluorouracil-dipeptide hydrogel.
abstract: The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates was highly dependent on concentration in solution, whereas, release from the fully formed hydrogels was significantly slower. The 5-Fu conjugate also exhibited promising in vitro cytotoxicity against human tumor cell lines A549, H460 and H23.
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, Ohio 43210, USA. parquett@chemistry.ohio-state.edu.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Sun
authors.forename: Jonah A
authors.initials: JA
authors.lastname: Kaplan
authors.forename: Aileen
authors.initials: A
authors.lastname: Shieh
authors.forename: Hui-Lung
authors.initials: HL
authors.lastname: Sun
authors.forename: Carlo M
authors.initials: CM
authors.lastname: Croce
authors.forename: Mark W
authors.initials: MW
authors.lastname: Grinstaff
authors.forename: Jon R
authors.initials: JR
authors.lastname: Parquette
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D005472:Fluorouracil / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D004151:Dipeptides; D020100:Hydrogels; C024575:lysyllysine; D005472:Fluorouracil