title: Dataset of mouse hippocampus profiled by LC-MS/MS for label-free quantitation.
abstract: This dataset reports on the analysis of mouse hippocampus by LC-MS/MS, from mice fed a diet that was either deficient in n-3 FA (n-3 Def) or sufficient in n-3 FA (n-3 Adq). Label free quantitative (LFQ) analysis of the mass spectrometry data identified 1008 quantifiable proteins, 115 of which were found to be differentially expressed between the two dietary groups (n=8 per group). This data article refers to the research article "Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus" (English et al., 2013 [1]), in which a more comprehensive interpretation and analysis of the data is given.
authors.affiliation: Department of Psychiatry, Royal College of Surgeons in Ireland, ERC Beaumont Hospital, Dublin, Ireland; Proteome Research Centre, School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland.
authors.forename: Jane A
authors.initials: JA
authors.lastname: English
authors.affiliation: Proteome Research Centre, School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland.
authors.forename: Caitriona
authors.initials: C
authors.lastname: Scaife
authors.affiliation: Department of Food and Life Science, Azabu University, Sagamihara, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Harauma
authors.affiliation: Department of Psychiatry, Royal College of Surgeons in Ireland, ERC Beaumont Hospital, Dublin, Ireland.
authors.forename: Melanie
authors.initials: M
authors.lastname: Focking
authors.affiliation: Proteome Research Centre, School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland.
authors.forename: Kieran
authors.initials: K
authors.lastname: Wynne
authors.affiliation: Proteome Research Centre, School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland.
authors.forename: Gerard
authors.initials: G
authors.lastname: Cagney
authors.affiliation: Department of Food and Life Science, Azabu University, Sagamihara, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Moriguchi
authors.affiliation: Department of Psychiatry, Royal College of Surgeons in Ireland, ERC Beaumont Hospital, Dublin, Ireland.
authors.forename: David R
authors.initials: DR
authors.lastname: Cotter
keywords: Brain; Hippocampus; Mass spectrometry; Mouse; Omega-3 deficiency; Proteins; Proteomics