title: Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse.
abstract: The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature and diagnostic criteria for nonproliferative and proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and diagnostic criteria for classifying lesions in the digestive system including the salivary glands and the exocrine pancreas of laboratory rats and mice. Most lesions are illustrated by color photomicrographs. The standardized nomenclature, the diagnostic criteria, and the photomicrographs are also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and age related lesions as well as lesions induced by exposure to test items. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature and diagnostic criteria for the digestive system will decrease misunderstandings among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.
authors.affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany; Chairman of the Digestive Tract INHAND Committee.
authors.forename: Thomas
authors.initials: T
authors.lastname: Nolte
authors.affiliation: Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland.
authors.forename: Patricia
authors.initials: P
authors.lastname: Brander-Weber
authors.affiliation: Jackson Laboratory, Bar Harbor, Maine 04609, USA. Present: Sanofi5 The Mountain Road, Framingham, Massachusetts 01740, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Dangler
authors.affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Deschl
authors.affiliation: Covance Laboratories, Inc. 14500 Avion Parkway, Ste 125, Chantilly, Virginia 20151, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Elwell
authors.affiliation: University of Leicester, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Science Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: Greaves
authors.affiliation: GlaxoSmithKline PO Box 14164 Durham, North Carolina 27709, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Hailey
authors.affiliation: Pfizer, Inc. One Burtt Road, Andover, MA 01810, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Leach
authors.affiliation: Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA; Experimental Pathology Laboratories, Inc. PO Box 12766, Research Triangle Park, North Carolina 27709, USA.
authors.forename: Arun R
authors.initials: AR
authors.lastname: Pandiri
authors.affiliation: Tufts University, Department of Biomedical Sciences, 274 Tremont Street, Massachusetts 02111, USA.
authors.forename: Arlin
authors.initials: A
authors.lastname: Rogers
authors.affiliation: Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
authors.forename: Cynthia C
authors.initials: CC
authors.lastname: Shackelford
authors.affiliation: Covance Laboratories Ltd, Alnwick Research Centre, Willowburn Avenue, Alnwick, Northumberland NE66 2JH United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Spencer
authors.affiliation: Gifu Municipal Hospital Gifu 500-8285, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Global VetPathology, Montgomery Village, MD, USA.
authors.forename: Jerrold M
authors.initials: JM
authors.lastname: Ward
keywords: diagnostic criteria; diagnostic pathology; digestive system or tract; esophagus; intestine; large intestine; nomenclature; oral cavity; pancreas se; salivary glands; small intestine; stomach