title: Calcium oxalate precipitation by diffusion using laminar microfluidics: toward a biomimetic model of pathological microcalcifications.
abstract: The effect of mixing calcium and oxalate precursors by diffusion at miscible liquid interfaces on calcium oxalate crystalline phases, and in physiological conditions (concentrations and flow rates), is studied using a microfluidic channel. This channel has similar dimensions as the collection duct in human kidneys and serves as a biomimetic model in order to understand the formation of pathological microcalcifications.
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR 8234 CNRS, Laboratoire Physico-chimie des Electrolytes et Nanosystèmes Interfaciaux (PHENIX), 4 place Jussieu - case 51, F-75005, Paris, France. ali.abou_hassan@upmc.fr and Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), 11 Place Marcelin Berthelot, Bat D, F-75005, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Laffite
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), 11 Place Marcelin Berthelot, Bat D, F-75005, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Leroy
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), 11 Place Marcelin Berthelot, Bat D, F-75005, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Bonhomme
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), 11 Place Marcelin Berthelot, Bat D, F-75005, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Bonhomme-Coury
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, AP-HP, INSERM, Service d'Explorations Fonctionnelles, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Letavernier
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, AP-HP, INSERM, Service d'Explorations Fonctionnelles, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Daudon
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, AP-HP, INSERM, Service d'Explorations Fonctionnelles, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Frochot
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, AP-HP, INSERM, Service d'Explorations Fonctionnelles, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Haymann
authors.affiliation: Laboratoire de Physique des Solides, CNRS UMR 8502, Université Paris-Sud, Bât 510, 91405, Orsay, France.
authors.forename: S
authors.initials: S
authors.lastname: Rouzière
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR 8235 CNRS, Laboratoire Interfaces et Systèmes Electrochimiques (LISE), 4 place Jussieu - case 133, F-75005, Paris, France.
authors.forename: I T
authors.initials: IT
authors.lastname: Lucas
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), 11 Place Marcelin Berthelot, Bat D, F-75005, Paris, France and Laboratoire de Physique des Solides, CNRS UMR 8502, Université Paris-Sud, Bât 510, 91405, Orsay, France.
authors.forename: D
authors.initials: D
authors.lastname: Bazin
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), 11 Place Marcelin Berthelot, Bat D, F-75005, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Babonneau
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR 8234 CNRS, Laboratoire Physico-chimie des Electrolytes et Nanosystèmes Interfaciaux (PHENIX), 4 place Jussieu - case 51, F-75005, Paris, France. ali.abou_hassan@upmc.fr.
authors.forename: A
authors.initials: A
authors.lastname: Abou-Hassan
mesh_terms: D032701:Biomimetics; D002114:Calcinosis / Q000473:pathology*; D002129:Calcium Oxalate / Q000737:chemistry* / Q000302:isolation & purification; D011232:Chemical Precipitation; D004058:Diffusion; D006801:Humans; D007668:Kidney / Q000473:pathology*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation; D010316:Particle Size; D013499:Surface Properties
chemical_list: D002129:Calcium Oxalate