title: Het cytochroom P450 enzymsysteem: wat is de relevantie voor de praktijk? Deel II, interacties.
abstract: In man a great interindividual variability exists in the oxidative capacity to metabolize drugs. A major factor contributing to this phenomenon is the genetically determined hydroxyla-tion-capacity of the cytochrome P450 enzyme system. The cytochrome P450 system comprises of several isozymes. For several isozymes (CYP2D6, CYP2C) a genetically based hydroxylation capacity has been demonstrated. A frequency distribution of the clearance shows a bimodal distribution with poor and extensive metabolizers. Applying standard dosing schemes of the drugs that are predominantly metabolised by these isozymes, a considerable number of patients will be intoxicated because of poor metabolism. In general, cytochrome P450 capacity is limited and substrate-affinity is high. Henceforth cytochrome P450 isozymes are likely targets for pharmacokinetic interactions.
authors.affiliation: *Apotheek,Academisch ziekenhuis Vrije Universiteit.
authors.forename: D J
authors.initials: DJ
authors.lastname: Touw
authors.affiliation: **Zenuwarts,Vincent van Gogh Instituut voor Geestelijke,Gezondheid.
authors.forename: W M
authors.initials: WM
authors.lastname: Verhoeven
authors.affiliation: ***Stichting Ziekenhuisapotheek en Klinisch Laboratorium Venray.
authors.forename: J B
authors.initials: JB
authors.lastname: Noten