title: In vivo reflectance confocal microscopy characterization of silver deposits in localized cutaneous argyria.
abstract: Localized cutaneous argyria is a rare condition secondary to skin deposition of silver following exposure to substances containing this metal. The clinical appearance and dermoscopy findings require deep melanocytic lesions and particularly melanoma metastasis to be ruled out. Silver deposits are usually confirmed by scanning electron microscopy and/or energy-dispersive X-ray spectroscopy. Herein we describe the in vivo reflectance confocal microscopy (RCM) features observed in one case of localized cutaneous argyria. These features include the presence of a hyperrefractile network in the papillary dermis and a periadnexal dotted bright pattern. In vivo RCM might be a useful tool for an early diagnosis of this uncommon entity.
authors.affiliation: Department of Dermatology, Hospital del Mar, Passeig Marítim, 25-29, ES-08003, Barcelona, Spain. 60782@parcdesalutmar.cat.
authors.forename: P
authors.initials: P
authors.lastname: García-Martínez
authors.affiliation: Department of Dermatology, Hospital del Mar, Passeig Marítim, 25-29, ES-08003, Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: López Aventín
authors.affiliation: Department of Dermatology, Hospital del Mar, Passeig Marítim, 25-29, ES-08003, Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Segura
authors.affiliation: Department of Dermatology, Hospital del Mar, Passeig Marítim, 25-29, ES-08003, Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Gómez-Martín
authors.affiliation: Department of Pathology, Hospital del Mar, Passeig Marítim, 25-29, ES-08003, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Lloreta
authors.affiliation: Institut de Ciències de la Terra Jaume Almera, CSIC, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ibáñez
authors.affiliation: Institut de Ciències de la Terra Jaume Almera, CSIC, Barcelona, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Elvira
authors.affiliation: Department of Dermatology, Hospital del Mar, Passeig Marítim, 25-29, ES-08003, Barcelona, Spain.
authors.forename: R M
authors.initials: RM
authors.lastname: Pujol
mesh_terms: D000369:Aged, 80 and over; D001129:Argyria / Q000000981:diagnostic imaging*; D046169:Dermoscopy / Q000379:methods; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal / Q000379:methods; D012834:Silver / Q000378:metabolism*; D012867:Skin / Q000378:metabolism
chemical_list: D012834:Silver