title: Association of Frontotemporal Dementia GWAS Loci with Late-Onset Alzheimer's Disease in a Northern Han Chinese Population.
abstract: Both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are a class of neurodegenerative diseases. Strong similarities in cerebrospinal fluid biomarker, imaging markers, and disease progression profiles suggest that some or most of the pathophysiology is shared between AD and FTD. A recent large genome-wide association study reported several single nucleotide polymorphisms (SNPs) at the RAB38, RAB38/CTSC, HLA-DRA/HLA-DRB5, and BTNL2 in association with FTD.
  
  
  
  To explore whether these SNPs are associated with AD risk.
  
  
  
  We conducted a case-control study to investigate the association of FTD-associated loci in 2338 Han Chinese subjects.
  
  
  
  We observed significant differences in genotype distributions of rs302668 (pc = 0.025), rs9268877 (pc = 0.025), rs9268856 (p <  0.001), and rs1980493 (pc = 0.045) between cases and controls. The SNPs rs16913634 for RAB38/CTSC was unrelated to LOAD risk (p = 0.088).
  
  
  
  The SNPs rs302668 in RAB38, rs9268877 and rs9268856 polymorphism in HLA-DRA/HLA-DRB5, and rs1980493 polymorphism in BTNL2 might play a role in the susceptibility to late-onset AD in the Han Chinese population.
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Tan
authors.forename: Yu
authors.initials: Y
authors.lastname: Wan
authors.forename: Meng-Shan
authors.initials: MS
authors.lastname: Tan
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Zi-Xuan
authors.initials: ZX
authors.lastname: Wang
authors.forename: Fu-Rong
authors.initials: FR
authors.lastname: Sun
authors.forename: Dan
authors.initials: D
authors.lastname: Miao
authors.forename: Lan
authors.initials: L
authors.lastname: Tan
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D057180:Frontotemporal Dementia / Q000235:genetics*; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008609:Mental Status Schedule; D020641:Polymorphism, Single Nucleotide
chemical_list: D053327:Apolipoprotein E4
keywords: Alzheimer’s disease; association study; frontotemporal dementia; polymorphism