title: Preformation Versus Epigenesis in Early Mammalian Development.
abstract: Whether or not early mammalian development results from preformation or epigenesis remains an unresolved issue. Evidence for or against either is weak, inconclusive, and often misinterpreted. Yet, one can parsimoniously conceptualize formation of the mouse blastocyst as a series of random, stochastic events stemming from initial and sequential small asymmetries in egg, zygote, and cleavage stages. Differential compartmentalized gene expression does not lead but follows the morphogenesis and cell fate allocation in the mammalian blastocyst.
authors.affiliation: Siriraj Center of Excellence in Stem Cell Research, Mahidol University, Bangkok, Thailand; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. Electronic address: davorsolter@mac.com.
authors.forename: Davor
authors.initials: D
authors.lastname: Solter
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000166:cytology*; D019070:Cell Lineage; D004622:Embryo, Mammalian / Q000166:cytology*; D044127:Epigenesis, Genetic; D006801:Humans; D051379:Mice; D009024:Morphogenesis / Q000502:physiology*; D015053:Zygote / Q000166:cytology*
keywords: Blastocyst; Early mammalian development; Epigenesis; Preformation; Zona pellucida; Zygote