title: Peptide receptor radionuclide therapy of neuroendocrine tumours.
abstract: In the past decades, the number of neuroendocrine tumours that are detected is increasing. A relative new and promising therapy for patients with metastasised or inoperable disease is peptide receptor radionuclide therapy (PRRT). This therapy involves an infusion of somatostatin analogues linked to radionuclides like Yttrium-90 or Lutetium-177. Objective response rates are reported in 15-35%. Response rates may vary between type of tumour and radionuclide. Besides the objective response rate, overall survival and progression free survival increase significantly. Also, the quality of life improves as well. Serious side-affects are rare. PRRT is usually well tolerated, also in patients with extensive metastasised disease. Recent studies combined PRRT with other types of therapies. Unfortunately no randomised trials comparing these strategies are available. In the future, more research is needed to evaluate the best therapy combinations or sequence of therapies.
authors.affiliation: Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: t.brabander@erasmusmc.nl.
authors.forename: Tessa
authors.initials: T
authors.lastname: Brabander
authors.affiliation: Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: j.teunissen@erasmusmc.nl.
authors.forename: Jaap J M
authors.initials: JJ
authors.lastname: Teunissen
authors.affiliation: Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: c.vaneijck@erasmusmc.nl.
authors.forename: Casper H J
authors.initials: CH
authors.lastname: Van Eijck
authors.affiliation: Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: g.franssen@erasmusmc.nl.
authors.forename: Gaston J H
authors.initials: GJ
authors.lastname: Franssen
authors.affiliation: Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: r.feelders@erasmusmc.nl.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Feelders
authors.affiliation: Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: w.w.deherder@erasmusmc.nl.
authors.forename: Wouter W
authors.initials: WW
authors.lastname: de Herder
authors.affiliation: Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: d.j.kwekkeboom@erasmusmc.nl.
authors.forename: Dik J
authors.initials: DJ
authors.lastname: Kwekkeboom
mesh_terms: D006801:Humans; D018358:Neuroendocrine Tumors / Q000532:radiotherapy*; D015282:Octreotide / Q000009:adverse effects / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000009:adverse effects / Q000627:therapeutic use*; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods*; D018000:Receptors, Peptide / Q000378:metabolism*
chemical_list: D019275:Radiopharmaceuticals; D018000:Receptors, Peptide; D015282:Octreotide
keywords: PRRT; neuroendocrine tumours; radionuclides; somatostatin receptor