title: Polymorphisms of the IL27 gene in a Chinese Han population complicated with pre-eclampsia.
abstract: IL-27 could inhibit the development of Th17 cells, and the Th17/regulatory T-cell imbalance may reverse maternal tolerance in pre-eclampsia (PE). The aim of this study was to investigate the association between genetic polymorphisms in IL27 with PE. Three SNPs in IL27 (rs153109, rs17855750, and rs181206) were genotyped in a Chinese Han cohort of 1040 PE patients and 1247 normal pregnant women using the TaqMan allelic discrimination real-time PCR method. The CC genotypic distribution of rs153109 was significantly higher among cases than controls (19.1% versus 13.3%, odds ratio [OR]: 1.54, 95% confidence interval [CI]: 1.23-1.93, p < 0.001), and the CT genotype was found to be significantly lower in cases than controls (41.7% versus 49.0%, OR: 0.74, 95% CI: 0.63-0.88, p < 0.001), disputing existing reports indicating the allele frequency of rs153109 is not significantly different between PE patients and controls. Additionally, the CC genotype of rs153109 was significantly more prevalent in PE cases than controls using a recessive model (p < 0.001). The allelic and genotypic frequencies of rs17855750 and rs181206 were not significantly different between two groups. Our results reveal that IL27 polymorphisms may be involved in the development of PE in Chinese Han population.
authors.affiliation: Department of Rheumatology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Rheumatology, the Affiliated Hospital of Qingdao University, Qingdao, China.|Department of Medical Imageology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Rheumatology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Rheumatology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Rheumatology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Hongda
authors.initials: H
authors.lastname: Liang
authors.affiliation: Department of Rheumatology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Xin
authors.affiliation: Department of Rheumatology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Rheumatology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Medical Imageology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Jizheng
authors.initials: J
authors.lastname: Lin
authors.affiliation: Prenatal diagnosis center, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D002681:China; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D064094:Interleukin-27 / Q000235:genetics*; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000208:ethnology / Q000235:genetics*; D011247:Pregnancy
chemical_list: D064094:Interleukin-27