title: A New Antibacterial Tetrahydronaphthalene Lignanamide, Foveolatamide, from the Stems of Ficusfoveolata.
abstract: An antibacterial assay-guided isolation of the crude ethyl acetate extract from Ficus foveolata stems afforded four compounds, including a tetrahydronaphthalene lignanamide, foveolatamide (1), together with two known lignanamides, flavifloramide B (2) and N-trans-grossamide (3), and a known phenolic amide, N-trans-feruloyltyramine (4). The structures of these compounds were established on the basis of NMR spectroscopic and MS techniques. Among the isolated compounds, only 1 showed satisfactory antibacterial activities against Streptococcus pyogenes, with an MIC and MBC value of 45 µM. This is the first report of these four compounds from the stems of F. foveolata.
authors.forename: Wirod
authors.initials: W
authors.lastname: Meerungrueang
authors.forename: Parkphoom
authors.initials: P
authors.lastname: Panichayupakaranant
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003373:Coumaric Acids / Q000737:chemistry* / Q000494:pharmacology*; D030681:Ficus / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry* / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*; D014439:Tyramine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D003373:Coumaric Acids; D009281:Naphthalenes; C000607091:foveolatamide; C074004:feruloyltyramine; D014439:Tyramine