title: Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity.
abstract: The complexes [Ag2(OOC-(CH2)n-COO)] (n=1-10) (1-10) were synthesised and reacted with 1,10-phenanthroline (phen) to yield derivatives formulating as [Ag2(phen)x(OOC-(CH2)y-COO)]·zH2O (x=2 or 3; y=1-10; z=1-4) (11-20) which are highly water-soluble and photo-stable in aqueous solution. The phen derivatives 11-20 exhibit chemotherapeutic potential against Candida albicans, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and against cisplatin-sensitive breast (MCF-7) and resistant ovarian (SKOV-3) cancer cell lines. Cyclic voltammetric analysis and DNA binding and intercalation studies indicate that the mechanism of action of 11-20 is significantly different to that of their silver(I) dicarboxylate precursors and they do not induce DNA damage or ROS generation in mammalian cells. The representative complexes 9 and 19 (containing the undecanedioate ligand) were both found to significantly reduce superoxide and hydrogen peroxide induced oxidative stress in the yeast S. cerevisiae.
authors.affiliation: The Inorganic Pharmaceutical and Biomimetic Research Centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland; Centre of Applied Science for Health, Institute of Technology Tallaght Dublin, Tallaght, Dublin 24, Ireland.
authors.forename: Laura
authors.initials: L
authors.lastname: Thornton
authors.affiliation: The Inorganic Pharmaceutical and Biomimetic Research Centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland.
authors.forename: Vidya
authors.initials: V
authors.lastname: Dixit
authors.affiliation: Laboratory of Cytotoxicity and Genotoxicity, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro (UFRJ), Brazil.
authors.forename: Letícia O N
authors.initials: LO
authors.lastname: Assad
authors.affiliation: Laboratory of Cytotoxicity and Genotoxicity, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro (UFRJ), Brazil.
authors.forename: Thales P
authors.initials: TP
authors.lastname: Ribeiro
authors.affiliation: Laboratory of Cytotoxicity and Genotoxicity, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro (UFRJ), Brazil.
authors.forename: Daniela D
authors.initials: DD
authors.lastname: Queiroz
authors.affiliation: School of Chemical Sciences and National Institute of Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
authors.forename: Andrew
authors.initials: A
authors.lastname: Kellett
authors.affiliation: The Inorganic Pharmaceutical and Biomimetic Research Centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland.
authors.forename: Alan
authors.initials: A
authors.lastname: Casey
authors.affiliation: The Inorganic Pharmaceutical and Biomimetic Research Centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland.
authors.forename: John
authors.initials: J
authors.lastname: Colleran
authors.affiliation: Laboratory of Cytotoxicity and Genotoxicity, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro (UFRJ), Brazil.
authors.forename: Marcos D
authors.initials: MD
authors.lastname: Pereira
authors.affiliation: The Inorganic Pharmaceutical and Biomimetic Research Centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland.
authors.forename: Garret
authors.initials: G
authors.lastname: Rochford
authors.affiliation: Chemistry Department, Maynooth University, National University of Ireland, Maynooth, Co. Kildare, Ireland.
authors.forename: Malachy
authors.initials: M
authors.lastname: McCann
authors.affiliation: The Inorganic Pharmaceutical and Biomimetic Research Centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland.
authors.forename: Denis
authors.initials: D
authors.lastname: O'Shea
authors.affiliation: The Inorganic Pharmaceutical and Biomimetic Research Centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland.
authors.forename: Rita
authors.initials: R
authors.lastname: Dempsey
authors.affiliation: Centre of Applied Science for Health, Institute of Technology Tallaght Dublin, Tallaght, Dublin 24, Ireland.
authors.forename: Siobhán
authors.initials: S
authors.lastname: McClean
authors.affiliation: Centre of Applied Science for Health, Institute of Technology Tallaght Dublin, Tallaght, Dublin 24, Ireland.
authors.forename: Agnieszka Foltyn-Arfa
authors.initials: AF
authors.lastname: Kia
authors.affiliation: Centre of Applied Science for Health, Institute of Technology Tallaght Dublin, Tallaght, Dublin 24, Ireland.
authors.forename: Maureen
authors.initials: M
authors.lastname: Walsh
authors.affiliation: Centre of Applied Science for Health, Institute of Technology Tallaght Dublin, Tallaght, Dublin 24, Ireland.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Creaven
authors.affiliation: The Inorganic Pharmaceutical and Biomimetic Research Centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland.
authors.forename: Orla
authors.initials: O
authors.lastname: Howe
authors.affiliation: The Inorganic Pharmaceutical and Biomimetic Research Centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland. Electronic address: Michael.Devereux@dit.ie.
authors.forename: Michael
authors.initials: M
authors.lastname: Devereux
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000254:growth & development*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002176:Candida albicans / Q000254:growth & development*; D005260:Female; D006801:Humans; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D061986:MCF-7 Cells; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010618:Phenanthrolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D012834:Silver / Q000737:chemistry / Q000494:pharmacology; D012995:Solubility
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D007364:Intercalating Agents; D010618:Phenanthrolines; D012834:Silver
keywords: Antimicrobial/anticancer; Antioxidant activity; DNA interactions; Silver complexes