title: Recent Advance in the Relationship between Excitatory Amino Acid Transporters and Parkinson's Disease.
abstract: Parkinson's disease (PD) is the most common movement disorder disease in the elderly and is characterized by degeneration of dopamine neurons and formation of Lewy bodies. Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). If glutamate is not removed promptly in the synaptic cleft, it will excessively stimulate the glutamate receptors and induce excitotoxic effects on the CNS. With lack of extracellular enzyme to decompose glutamate, glutamate uptake in the synaptic cleft is mainly achieved by the excitatory amino acid transporters (EAATs, also known as high-affinity glutamate transporters). Current studies have confirmed that decreased expression and function of EAATs appear in PD animal models. Moreover, single unilateral administration of EAATs inhibitor in the substantia nigra mimics several PD features and this is a solid evidence supporting that decreased EAATs contribute to the process of PD. Drugs or treatments promoting the expression and function of EAATs are shown to attenuate dopamine neurons death in the substantia nigra and striatum, ameliorate the behavior disorder, and improve cognitive abilities in PD animal models. EAATs are potential effective drug targets in treatment of PD and thus study of relationship between EAATs and PD has predominant medical significance currently.
authors.affiliation: Department of Blood Transfusion, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510900, China; Department of Traditional Chinese Medicine, College of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan, Guangdong 528000, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Tan
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510080, China.
authors.forename: Pingyi
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Blood Transfusion, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510900, China.
authors.forename: Shaogang
authors.initials: S
authors.lastname: Qu
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D050491:Glutamate Plasma Membrane Transport Proteins / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism; D009435:Synaptic Transmission
chemical_list: D050491:Glutamate Plasma Membrane Transport Proteins; D018698:Glutamic Acid