title: LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19.
authors.affiliation: Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium Center for Medical Genetics, Ghent University, Belgium.
authors.forename: Hetty H
authors.initials: HH
authors.lastname: Helsmoortel
authors.affiliation: Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium.
authors.forename: Barbara
authors.initials: B
authors.lastname: De Moerloose
authors.affiliation: Center for Medical Genetics, Ghent University, Belgium Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University, Belgium Department of Biomedical Molecular Biology, Ghent University, Belgium.
authors.forename: Tim
authors.initials: T
authors.lastname: Pieters
authors.affiliation: Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium Center for Medical Genetics, Ghent University, Belgium.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Ghazavi
authors.affiliation: Department of Women and Child Health, University of Padova, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bresolin
authors.affiliation: Department of Genetics, University Hospital of Robert Debré and Paris-Diderot University, Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Cavé
authors.affiliation: Department of Paediatric Oncology/Haematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.
authors.forename: Andrica
authors.initials: A
authors.lastname: de Vries
authors.affiliation: Dutch Childhood Oncology Group (DCOG), the Hague, the Netherlands.
authors.forename: Valerie
authors.initials: V
authors.lastname: de Haas
authors.affiliation: Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Flotho
authors.affiliation: Pediatric Haemato-Oncology, University Hospitals Leuven, Belgium.
authors.forename: Veerle
authors.initials: V
authors.lastname: Labarque
authors.affiliation: Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg, Germany.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Niemeyer
authors.affiliation: Pathological Anatomy, AZ Sint Jan Bruges, Belgium.
authors.forename: Pascale
authors.initials: P
authors.lastname: De Paepe
authors.affiliation: Center for Medical Genetics, Ghent University, Belgium.
authors.forename: Nadine
authors.initials: N
authors.lastname: Van Roy
authors.affiliation: Department of Paediatric Haematology/Oncology, Charles University and University Hospital Motol, Prague, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Stary
authors.affiliation: Dutch Childhood Oncology Group (DCOG), the Hague, the Netherlands Princess Maxima Center for Paediatric Oncology, Utrecht, the Netherlands.
authors.forename: Marry M
authors.initials: MM
authors.lastname: van den Heuvel-Eibrink
authors.affiliation: Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium.
authors.forename: Yves
authors.initials: Y
authors.lastname: Benoit
authors.affiliation: Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany Department of Paediatric Oncology and Haematology, University Children's Hospital Essen, Essen, Germany German Consortium for Translational Cancer Research (DKTK), Essen, Germany Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Germany Centre for Medical Biotechnology, University Duisburg-Essen, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Schulte
authors.affiliation: Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University, Belgium Department of Biomedical Molecular Biology, Ghent University, Belgium.
authors.forename: Steven
authors.initials: S
authors.lastname: Goossens
authors.affiliation: Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University, Belgium Department of Biomedical Molecular Biology, Ghent University, Belgium.
authors.forename: Geert
authors.initials: G
authors.lastname: Berx
authors.affiliation: Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
authors.forename: Jody J
authors.initials: JJ
authors.lastname: Haigh
authors.affiliation: Center for Medical Genetics, Ghent University, Belgium.
authors.forename: Frank
authors.initials: F
authors.lastname: Speleman
authors.affiliation: Center for Medical Genetics, Ghent University, Belgium.
authors.forename: Pieter
authors.initials: P
authors.lastname: Van Vlierberghe
authors.affiliation: Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium Tim.Lammens@UGent.be.
authors.forename: Tim
authors.initials: T
authors.lastname: Lammens
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C094335:H19 long non-coding RNA; C516326:LIN28B protein, human; D009363:Neoplasm Proteins; D062085:RNA, Long Noncoding; D012334:RNA, Neoplasm; D016601:RNA-Binding Proteins
keywords: IncRNA H19 regulation; LIN28B overexpression; pediatric leukemia