title: Supersize my brain: A cross-sectional voxel-based morphometry study on the association between self-reported dietary restraint and regional grey matter volumes.
abstract: Restrained eaters do not eat less than their unrestrained counterparts. Proposed underlying mechanisms are that restrained eaters are more reward sensitive and that they have worse inhibitory control. Although fMRI studies assessed these mechanisms, it is unknown how brain anatomy relates to dietary restraint. Voxel-based morphometry was performed on anatomical scans from 155 normal-weight females to investigate how regional grey matter volume correlates with restraint. A positive correlation was found in several areas, including the parahippocampal gyrus, hippocampus, striatum and the amygdala (bilaterally, p<0.05, corrected). A negative correlation was found in several areas, including the inferior frontal gyrus, superior frontal gyrus, supplementary motor area, middle cingulate cortex and precentral gyrus (p<0.05, corrected). That higher restraint relates to higher grey matter volume in reward-related areas and lower grey matter volume in regions involved in inhibition, provides a neuroanatomical underpinning of theories relating restraint to increased reward sensitivity and reduced inhibitory capacity.
authors.affiliation: Image Sciences Institute, University Medical Center Utrecht, Postal address: Heidelberglaan 100 Q02.4.45, 3584CX Utrecht, The Netherlands. Electronic address: nynke@isi.uu.nl.
authors.forename: Laura N
authors.initials: LN
authors.lastname: van der Laan
authors.affiliation: Image Sciences Institute, University Medical Center Utrecht, Postal address: Heidelberglaan 100 Q02.4.45, 3584CX Utrecht, The Netherlands.
authors.forename: Lisette
authors.initials: L
authors.lastname: Charbonnier
authors.affiliation: Division of Human Nutrition, Wageningen University and Research centre, Postal address: PO box 8129, bode 62, 6700 EV Wageningen, The Netherlands.
authors.forename: Sanne
authors.initials: S
authors.lastname: Griffioen-Roose
authors.affiliation: Department of Clinical and Health Psychology, Utrecht University, Postal address: Padualaan 14, 3584CH Utrecht, The Netherlands.
authors.forename: Floor M
authors.initials: FM
authors.lastname: Kroese
authors.affiliation: Division of Human Nutrition, Wageningen University and Research centre, Postal address: PO box 8129, bode 62, 6700 EV Wageningen, The Netherlands.
authors.forename: Inge
authors.initials: I
authors.lastname: van Rijn
authors.affiliation: Image Sciences Institute, University Medical Center Utrecht, Postal address: Heidelberglaan 100 Q02.4.45, 3584CX Utrecht, The Netherlands; Division of Human Nutrition, Wageningen University and Research centre, Postal address: PO box 8129, bode 62, 6700 EV Wageningen, The Netherlands.
authors.forename: Paul A M
authors.initials: PAM
authors.lastname: Smeets
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005247:Feeding Behavior / Q000523:psychology*; D005260:Female; D066128:Gray Matter / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D012201:Reward; D057566:Self Report; D055815:Young Adult
keywords: Dietary restraint; Grey matter volume; Voxel-based morphometry