title: Summary of clinical and laboratory data of study subjects with and without DCE-MRI plaque measurements in the AIM-HIGH clinical trial.
abstract: This brief data article summarizes the clinical risk factors and laboratory data of a group of subjects recruited for the AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes) and an associated magnetic resonance imaging (MRI) substudy. The sample is restricted to those on statin therapy at the time of enrollment and data are presented stratified by whether dynamic contrast enhanced MRI (DCE-MRI) markers of carotid plaque vascularity and inflammation were available or not. The data provided herein are directly related to the article "Longer Duration of Statin Therapy is Associated with Decreased Carotid Plaque Vascularity by Magnetic Resonance Imaging" [2].
authors.affiliation: Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: O'Brien
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA, USA.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Hippe
authors.affiliation: Center for Biomedical Imaging Research, Tsinghua University, Beijing, China.
authors.forename: Huijun
authors.initials: H
authors.lastname: Chen
authors.affiliation: The Mountain-Whisper-Light Statistics, Seattle, WA, USA.
authors.forename: Moni B
authors.initials: MB
authors.lastname: Neradilek
authors.affiliation: Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Probstfield
authors.affiliation: Center for Child Health, Behavior and Development, Seattle Children׳s Research Institute, Seattle, WA, USA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Peck
authors.affiliation: Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Isquith
authors.affiliation: Department of Mechanical Engineering, University of Washington, Seattle, WA, USA.
authors.forename: Gador
authors.initials: G
authors.lastname: Canton
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA, USA.
authors.forename: Chun
authors.initials: C
authors.lastname: Yuan
authors.affiliation: The Mountain-Whisper-Light Statistics, Seattle, WA, USA.
authors.forename: Nayak L
authors.initials: NL
authors.lastname: Polissar
authors.affiliation: Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Xue-Qiao
authors.initials: XQ
authors.lastname: Zhao
authors.affiliation: Presage Biosciences, Inc., Seattle, WA, USA.
authors.forename: William S
authors.initials: WS
authors.lastname: Kerwin
keywords: AIM-HIGH, Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglyceride and Impact on Global Health Outcomes; Atherosclerosis; Carotid artery; DCE-MRI, dynamic contrast-enhanced magnetic resonance imaging; Inflammation; Ktrans, transfer constant; Magnetic resonance imaging; Plaque; Statin; Vp, fractional plasma volume