title: Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors.
abstract: Positron emission tomography (PET) neuroimaging of ion channel linked receptors is a developing area of preclinical and clinical research. The present review focuses on recent advances with radiochemistry, preclinical and clinical PET imaging studies of three receptors that are actively pursued in neuropsychiatric drug discovery: namely the γ-aminobutyric acid-benzodiazapine (GABA) receptor, nicotinic acetylcholine receptor (nAChR), and N-methyl-D-aspartate (NMDA) receptor. Recent efforts to develop new PET radioligands for these targets with improved brain uptake, selectivity, stability and pharmacokinetics are highlighted.
authors.forename: Alina
authors.initials: A
authors.lastname: Kassenbrock
authors.forename: Neil
authors.initials: N
authors.lastname: Vasdev
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. liang.steven@mgh.harvard.edu.
authors.forename: Steven H
authors.initials: SH
authors.lastname: Liang
mesh_terms: D014150:Antipsychotic Agents / Q000378:metabolism / Q000493:pharmacokinetics; D055808:Drug Discovery; D006801:Humans; D015394:Molecular Structure; D049268:Positron-Emission Tomography; D011868:Radioisotopes / Q000032:analysis* / Q000378:metabolism*; D018079:Receptors, GABA / Q000032:analysis* / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis* / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000032:analysis* / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D011868:Radioisotopes; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate; D011978:Receptors, Nicotinic