title: Piperine Augments the Protective Effect of Curcumin Against Lipopolysaccharide-Induced Neurobehavioral and Neurochemical Deficits in Mice.
abstract: The aim of the present study was to investigate the protective effects of curcumin alone and in combination with piperine against lipopolysaccharide (LPS)-induced neurobehavioral and neurochemical deficits in the mice hippocampus. Mice were treated with curcumin (100, 200, and 400 mg/kg, p.o.) and piperine (20 mg/kg, p.o.) for 7 days followed by LPS (0.83 mg/kg, i.p.) administration. Animals exhibited anxiety and depressive-like phenotype after 3 and 24 h of LPS exposure, respectively. LPS administration increased the oxido-nitrosative stress as evident by elevated levels of malondialdehyde, nitrite, and depletion of glutathione level in the hippocampus. Furthermore, we found raised level of pro-inflammatory cytokines (IL-1β and TNF-α) in the hippocampus of LPS-treated mice. Pretreatment with curcumin alleviated LPS-induced neurobehavioral and neurochemical deficits. Furthermore, co-administration of curcumin with piperine significantly potentiated the neuroprotective effect of curcumin. These results demonstrate that piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.
authors.affiliation: Department of Pharmacology and Toxicology, Laboratory of Neuroscience, National Institute of Pharmaceutical Education and Research, Guwahati, Assam, 781032, India. ashokjangra123@gmail.com.
authors.forename: Ashok
authors.initials: A
authors.lastname: Jangra
authors.affiliation: Department of Pharmacology and Toxicology, Laboratory of Neuroscience, National Institute of Pharmaceutical Education and Research, Guwahati, Assam, 781032, India.
authors.forename: Mohit
authors.initials: M
authors.lastname: Kwatra
authors.affiliation: Department of Pharmacology and Toxicology, Laboratory of Neuroscience, National Institute of Pharmaceutical Education and Research, Guwahati, Assam, 781032, India.
authors.forename: Tavleen
authors.initials: T
authors.lastname: Singh
authors.affiliation: Department of Pharmacology and Toxicology, Laboratory of Neuroscience, National Institute of Pharmaceutical Education and Research, Guwahati, Assam, 781032, India.
authors.forename: Rajat
authors.initials: R
authors.lastname: Pant
authors.affiliation: Department of Pharmacology and Toxicology, Laboratory of Neuroscience, National Institute of Pharmaceutical Education and Research, Guwahati, Assam, 781032, India.
authors.forename: Pawan
authors.initials: P
authors.lastname: Kushwah
authors.affiliation: Department of Pharmacology and Toxicology, Laboratory of Neuroscience, National Institute of Pharmaceutical Education and Research, Guwahati, Assam, 781032, India.
authors.forename: Yogita
authors.initials: Y
authors.lastname: Sharma
authors.affiliation: Department of Biotechnology, University Institute of Engineering & Technology (UIET), Maharishi Dayanand University, Rohtak, Haryana, India.
authors.forename: Babita
authors.initials: B
authors.lastname: Saroha
authors.affiliation: National Brain Research Centre, Manesar, Gurgaon, Haryana, India.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Datusalia
authors.affiliation: Department of Pharmacology, Gauhati Medical College, Guwahati, Assam, India.
authors.forename: Babul Kumar
authors.initials: BK
authors.lastname: Bezbaruah
mesh_terms: D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D052117:Benzodioxoles / Q000494:pharmacology* / Q000627:therapeutic use; D003474:Curcumin / Q000494:pharmacology* / Q000627:therapeutic use; D004357:Drug Synergism; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D008070:Lipopolysaccharides; D051379:Mice; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use; D053284:Polyunsaturated Alkamides / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D008070:Lipopolysaccharides; D018696:Neuroprotective Agents; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D003474:Curcumin; C008922:piperine
keywords: anxiety; curcumin; depression; oxido-nitrostative stress; piperine