title: Benzimidazolium-based novel silver N-heterocyclic carbene complexes: synthesis, characterisation and in vitro antimicrobial activity.
abstract: This study reports the synthesis, characterisation and antimicrobial activity of five novel silver N-heterocyclic carbene (Ag-NHC) complexes obtained by N-propylphthalimide and N-methyldioxane substituted benzimidazolium salts with silver oxide. The reactions were performed at room temperature for 24 h in the absence of light. The obtained complexes were identified and characterised by (1)H and (13)C NMR, FT-IR and elemental analysis techniques. The minimum inhibitory concentration (MIC) of the complexes was determined for E. coli, P. aeruginosa, E. faecalis, S. aureus, C. tropicalis and C. albicans in vitro through agar and broth dilution. The results indicated that these complexes exhibit antimicrobial activity. In particular, complex 3 presented the significant broad spectrum antimicrobial activity.
authors.affiliation: a Department of Chemistry , Faculty of Science and Arts, Inönü University , Malatya , Turkey .
authors.forename: Yakup
authors.initials: Y
authors.lastname: Sarı
authors.affiliation: b Department of Chemistry , Faculty of Science, Erciyes University , Kayseri , Turkey .|c Faculty of Pharmacy , The University of Sydney , Sydney , Australia , and.
authors.forename: Senem
authors.initials: S
authors.lastname: Akkoç
authors.affiliation: a Department of Chemistry , Faculty of Science and Arts, Inönü University , Malatya , Turkey .
authors.forename: Yetkin
authors.initials: Y
authors.lastname: Gök
authors.affiliation: c Faculty of Pharmacy , The University of Sydney , Sydney , Australia , and.
authors.forename: Vicki
authors.initials: V
authors.lastname: Sifniotis
authors.affiliation: a Department of Chemistry , Faculty of Science and Arts, Inönü University , Malatya , Turkey .
authors.forename: İlknur
authors.initials: İ
authors.lastname: Özdemir
authors.affiliation: d Department of Microbiology , Faculty of Medicine, Inönü University , Malatya , Turkey.
authors.forename: Selami
authors.initials: S
authors.lastname: Günal
authors.affiliation: c Faculty of Pharmacy , The University of Sydney , Sydney , Australia , and.
authors.forename: Veysel
authors.initials: V
authors.lastname: Kayser
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D066244:Proton Magnetic Resonance Spectroscopy; D012834:Silver / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D001562:Benzimidazoles; C030011:carbene; D012834:Silver; D008697:Methane
keywords: Antimicrobial activity; N-heterocyclic carbene; benzimidazole; silver complex