title: The role of leptin in diabetes: metabolic effects.
abstract: While it is well established that the adiposity hormone leptin plays a key role in the regulation of energy homeostasis, growing evidence suggests that leptin is also critical for glycaemic control. In this review we examine the role of the brain in the glucose-lowering actions of leptin and the potential mediators responsible for driving hyperglycaemia in states of uncontrolled insulin-deficient diabetes (uDM). These considerations highlight the possibility of targeting leptin-sensitive pathways as a therapeutic option for the treatment of diabetes. This review summarises a presentation given at the 'Is leptin coming back?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Christoffer Clemmensen and colleagues, DOI: 10.1007/s00125-016-3906-7 , and by Gerald Shulman and colleagues, DOI: 10.1007/s00125-016-3909-4 ) and an overview by the Session Chair, Ulf Smith (DOI: 10.1007/s00125-016-3894-7 ).
authors.affiliation: Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington at South Lake Union, 850 Republican St., N335, Box 358055, Seattle, WA, 98195, USA.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Meek
authors.affiliation: Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington at South Lake Union, 850 Republican St., N335, Box 358055, Seattle, WA, 98195, USA. gjmorton@u.washington.edu.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Morton
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003345:Corticosterone / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D020738:Leptin / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D020738:Leptin; D003345:Corticosterone
keywords: Brain; Corticosterone; Diabetes; Glucagon; Hepatic glucose production; Leptin; Review