title: [Effectiveness and safety of bronchial thermoplasty in patients with severe asthma].
abstract: OBJECTIVE
  To assess the effectiveness and safety of bronchial thermoplasty (BT) in patients with severe asthma.
  
  
  METHODS
  The China-Japan Friendship Hospital recruited 12 patients with severe asthma who were voluntary to take BT treatment from March 2014 to November 2014. The levels of airway inflammation and biological markers (percentage of blood eosinophils, percentage of sputum eosinophils, serum IgE, fractional exhaled nitric oxide) of the patients were examined before the treatment in order to identify the types of airway inflammation. The numbers of severe exacerbations and related hospitalizations within 1 year before and after BT were obtained for each patient. The occurrence of adverse events within 3 weeks after the treatment was collected. And the patient status within 1 year after the BT treatment was compared with that before the treatment, in terms of the number of severe exacerbations, exacerbation rate, the number of related hospitalizations, hospitalization rate and oral corticosteroid dose.
  
  
  RESULTS
  For before and 1 year after the treatment, the numbers of subjects suffering severe exacerbations were 11 and 6, the numbers of total severe exacerbation were 76 and 16, the numbers of patients hospitalized due to acute attacks were 10 and 3, and the numbers of total hospitalizations were 56 and 6, respectively. The severe exacerbation rate, hospitalization rate and oral corticosteroid dose were significantly reduced 1 year after the treatment [(1.3±0.48 vs. 6.3±1.9) events/subject/year, (0.50±0.26 vs. 4.67±1.90) events/subject/year, (8.5±4.6 vs. 22.0±2.6) mg/d, P<0.05]. The most common adverse events within 3 weeks after BT treatment were cough (8 events), expectoration (20 events), temporary PEF reduction (7 events), wheezing (4 events), but most of these symptoms were relieved in 1 week. One subject suffered pneumonia after each of the 3 procedures but also recovered soon after an antibiotic therapy. No adverse events occurred because of BT treatment within 3 weeks after the treatment. Computed tomographic scans from baseline to 1 year after the BT treatment showed no structural abnormalities related to BT.
  
  
  CONCLUSIONS
  These data demonstrate the benefits of BT with regard to both asthma control (based on reduction in severe exacerbations and hospitalizations due to acute exacerbations) and safety. BT might offer a new approach to treating severe asthma.
authors.affiliation: Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Nong
authors.forename: Nan
authors.initials: N
authors.lastname: Su
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Lin
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.forename: Chunyan
authors.initials: C
authors.lastname: Han
authors.forename: Yongming
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhang
authors.forename: Zhencui
authors.initials: Z
authors.lastname: Ren
authors.forename: Xiaopan
authors.initials: X
authors.lastname: Li
mesh_terms: D000305:Adrenal Cortex Hormones; D001249:Asthma / Q000628:therapy*; D015415:Biomarkers / Q000032:analysis; D001999:Bronchoscopy; D004804:Eosinophils; D006760:Hospitalization; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D012135:Respiratory Sounds; D013183:Sputum / Q000166:cytology
chemical_list: D000305:Adrenal Cortex Hormones; D015415:Biomarkers; D007073:Immunoglobulin E