title: [Construction of automatic elucidation platform for mechanism of traditional Chinese medicine].
abstract: Aim at the two problems in the field of traditional Chinese medicine (TCM) mechanism elucidation, one is the lack of detailed biological processes information, next is the low efficient in constructing network models, we constructed an auxiliary elucidation system for the TCM mechanism and realize the automatic establishment of biological network model. This study used the Entity Grammar Systems (EGS) as the theoretical framework, integrated the data of formulae, herbs, chemical components, targets of component, biological reactions, signaling pathways and disease related proteins, established the formal models, wrote the reasoning engine, constructed the auxiliary elucidation system for the TCM mechanism elucidation. The platform provides an automatic modeling method for biological network model of TCM mechanism. It would be benefit to perform the in-depth research on TCM theory of natures and combination and provides the scientific references for R&D of TCM.
authors.forename: Bai-xia
authors.initials: BX
authors.lastname: Zhang
authors.forename: Si-jun
authors.initials: SJ
authors.lastname: Luo
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
authors.forename: Hao
authors.initials: H
authors.lastname: Gu
authors.forename: Ji
authors.initials: J
authors.lastname: Luo
authors.forename: Yan-ling
authors.initials: YL
authors.lastname: Zhang
authors.forename: Ou
authors.initials: O
authors.lastname: Tao
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D001331:Automation / Q000295:instrumentation / Q000379:methods*; D016208:Databases, Factual; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D053263:Gene Regulatory Networks; D006801:Humans; D008516:Medicine, Chinese Traditional; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal