title: [Biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulphated derivatives].
abstract: The review considers recent experimental studies of biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives in diseases associated with disorders of carbohydrate and lipid metabolism. Particular attention is focused on the results of studies showing a high therapeutic potential of these phenolic compounds in their prophylactic and therapeutic use at experimental modeling of type 2 diabetes and hyperlipidemia. Based on the analysis of our results and the literature data putative mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives have been proposed.
authors.affiliation: Elyakov Pacibic Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia; Far Eastern Federal University, Vladivostok, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Popov
authors.affiliation: Elyakov Pacibic Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: O N
authors.initials: ON
authors.lastname: Krivoshapko
authors.affiliation: Elyakov Pacibic Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Klimovich
authors.affiliation: Elyakov Pacibic Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Artyukov
mesh_terms: D000818:Animals; D002934:Cinnamates / Q000493:pharmacokinetics / Q000627:therapeutic use; D053630:Depsides / Q000493:pharmacokinetics / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism; D047311:Luteolin / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use; D000097123:Rosmarinic Acid
chemical_list: D002934:Cinnamates; D053630:Depsides; D047311:Luteolin; D000097123:Rosmarinic Acid
keywords: atherosclerosis; flavonoids; hyperlipidemia; luteolin; rosmarinic acid; type 2 diabetes