title: Investigation of KIF6 Trp719Arg gene polymorphism in a case-control study of coronary artery disease and non-fatal myocardial infarction in the Eastern Province of Saudi Arabia.
abstract: BACKGROUND
  Kinesin-like protein 6 (KIF6), a member of the kinesin superfamily, is involved in intracellular transport. A few prospective studies have shown the KIF6 variant Trp719Arg (rs20455) to be associated with coronary artery disease (CAD) in Caucasian populations. However, recent genome-wide association studies on CAD have not proven these associations.
  
  
  OBJECTIVE
  Since the role of KIF6 719Arg allele in other ethnic populations is largely unknown, we sought to determine whether the KIF6 719Arg allele is associated with CAD in an ethnic Middle Eastern population.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  CAD patients and control subjects from King Fahd Hospital of the University, Al-Khobar, Saudi Arabia.
  
  
  METHODS
  The study population included angiographically defined CAD patients (n=1002) and controls (n=984) with a normal electrocardiogram.
  
  
  METHODS
  Association of KIF6 Trp719Arg mutation with CAD.
  
  
  RESULTS
  The KIF6 Trp719Arg polymorphism was not associated with CAD (OR 0.976, 95% CI 0.861-1.105; P=.704). In addition, KIF6 Trp719Arg polymorphism showed a lack of association even in stratified myocardial infarction patients (n=802) (OR 1.006, 95% CI 0.881-1.148; P=.929) in comparison to controls.
  
  
  CONCLUSIONS
  The absence of Trp719Arg polymorphism association with CAD and CAD in stratified myocardial infarction cases indicates that the polymorphism is not associated with an increased risk among CAD patients from the Eastern Province of Saudi Arabia.
  
  
  CONCLUSIONS
  Unavailability of data on statin usage among the patient population.
authors.forename: Chittibabu
authors.initials: C
authors.lastname: Vatte
authors.affiliation: Dr. Cyril Cyrus, University of Dammam, 31441 Saudi Arabia, T: +96613330866, ccyrus@uod.edu.sa.
authors.forename: Cyril
authors.initials: C
authors.lastname: Cyrus
authors.forename: Abdullah Mohammed
authors.initials: AM
authors.lastname: Al Shehri
authors.forename: Shahanas
authors.initials: S
authors.lastname: Chathoth
authors.forename: Mohammed
authors.initials: M
authors.lastname: Almansori
authors.forename: Awatif
authors.initials: A
authors.lastname: Al-Nafaie
authors.forename: Rudaynah
authors.initials: R
authors.lastname: Al-Ali
authors.forename: Fahad
authors.initials: F
authors.lastname: Al-Muhanna
authors.forename: Folkert W
authors.initials: FW
authors.lastname: Asselbergs
authors.forename: Amein
authors.initials: A
authors.lastname: Al-Ali
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016547:Kinesins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012529:Saudi Arabia
chemical_list: C526774:KIF6 protein, human; D016547:Kinesins