title: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for treatment of ovarian cancer.
abstract: Hyperthermic intraperitoneal chemotherapy (HIPEC), a strategy combining maximal cytoreductive surgery and maximal regional chemotherapy, has been applied to treat ovarian cancer resulting in long-term survival rates in selected patients. However, the status of HIPEC in ovarian cancer remains an experimental procedure, given the many variables among the data and trials reviewed, to enable us to derive strong conclusions about its role from this overview. In this review we discuss treatment with HIPEC in patients with ovarian cancer and future prospective of its use in clinical setting. HIPEC is an effective tool in the treatment of selected patients with peritoneal carcinomatosis from ovarian cancer. Unfortunately, due to the lack of randomised trials, the evidence of HIPEC is very limited. Future randomised studies are awaited to define the role and clinical impact of HIPEC in ovarian cancer.
authors.affiliation: a Unit of General and Minimally Invasive Surgery, Surgery and Neuroscience , University of Sienna , Sienna ;
authors.forename: Karol
authors.initials: K
authors.lastname: Polom
authors.affiliation: b Section of Pharmacology and University Centre, DIFF - Drug Innovation Forward Future, Department of Molecular and Translational Medicine , University of Brescia , Brescia ;|c Unit of Molecular Therapy and Pharmacogenomics , AO Azienda Istituti Ospitalieri di Cremona , Cremona ;
authors.forename: Giandomenico
authors.initials: G
authors.lastname: Roviello
authors.affiliation: c Unit of Molecular Therapy and Pharmacogenomics , AO Azienda Istituti Ospitalieri di Cremona , Cremona ;|d Department of Medical, Surgery and Health Sciences , University of Trieste , Trieste ;
authors.forename: Daniele
authors.initials: D
authors.lastname: Generali
authors.affiliation: e General, Minimally Invasive, and Robotic Surgery, Department of Surgery , 'San Matteo degli Infermi' Hospital , Spoleto ;
authors.forename: Luigi
authors.initials: L
authors.lastname: Marano
authors.affiliation: f Medical Oncology Unit , University of Sienna , Sienna ;
authors.forename: Roberto
authors.initials: R
authors.lastname: Petrioli
authors.affiliation: f Medical Oncology Unit , University of Sienna , Sienna ;
authors.forename: Stefania
authors.initials: S
authors.lastname: Marsili
authors.affiliation: a Unit of General and Minimally Invasive Surgery, Surgery and Neuroscience , University of Sienna , Sienna ;
authors.forename: Edda
authors.initials: E
authors.lastname: Caputo
authors.affiliation: g Department of Medical, Surgical and Neurosciences , Section of Advanced Surgical Oncology, University of Sienna , Sienna , Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Marrelli
authors.affiliation: a Unit of General and Minimally Invasive Surgery, Surgery and Neuroscience , University of Sienna , Sienna ;
authors.forename: Franco
authors.initials: F
authors.lastname: Roviello
mesh_terms: D000818:Animals; D010478:Chemotherapy, Cancer, Regional Perfusion; D003131:Combined Modality Therapy; D065426:Cytoreduction Surgical Procedures; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery / Q000628:therapy*; D011379:Prognosis; D016896:Treatment Outcome
keywords: Cytoreductive surgery; Epithelial ovarian cancer; HIPEC; Hyperthermic intraperitoneal chemotherapy