title: Epigenetic germline inheritance of diet-induced obesity and insulin resistance.
abstract: There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.
authors.affiliation: Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.|German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.|German Center for Diabetes Research (DZD), Neuherberg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Huypens
authors.affiliation: Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Sass
authors.affiliation: Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.|German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.
authors.forename: Moya
authors.initials: M
authors.lastname: Wu
authors.affiliation: Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.|German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.|German Center for Diabetes Research (DZD), Neuherberg, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Dyckhoff
authors.affiliation: German Center for Diabetes Research (DZD), Neuherberg, Germany.|Institute of Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.|Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Tschöp
authors.affiliation: Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.|Department of Mathematics, Technische Universität München, Garching, Germany.
authors.forename: Fabian
authors.identifier: 0000-0002-2419-1943
authors.initials: F
authors.lastname: Theis
authors.affiliation: Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.|German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.
authors.forename: Susan
authors.initials: S
authors.lastname: Marschall
authors.affiliation: Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.|German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.|German Center for Diabetes Research (DZD), Neuherberg, Germany.|Chair of Experimental Genetics, Technische Universität München, Freising, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Hrabě de Angelis
authors.affiliation: Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.|German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.|German Center for Diabetes Research (DZD), Neuherberg, Germany.|Chair of Experimental Genetics, Technische Universität München, Freising, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Beckers
mesh_terms: D000818:Animals; D059305:Diet, High-Fat; D044127:Epigenesis, Genetic; D005260:Female; D005307:Fertilization in Vitro; D020022:Genetic Predisposition to Disease; D005854:Germ Cells; D040582:Inheritance Patterns; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000235:genetics*