title: Association between Serum Uric Acid and Mortality among Chinese Patients with Coronary Artery Disease.
abstract: Several studies have investigated the association between serum uric acid (SUA) and the risks of coronary artery disease (CAD) but have yielded inconsistent results. The aim of this study was to assess whether there is an independent association of SUA with all-cause and cardiovascular disease (CVD) mortality in Chinese patients with CAD.
  
  
  
  A prospective cohort study of 1,799 patients was conducted. Cox regression models were used to estimate the association of SUA with the risk of death.
  
  
  
  During a median follow-up of 3.9 years, 177 deaths were recorded and 126 of these were due to CVD. Patients in the highest SUA quartile had a 2.43-fold risk of all-cause mortality and a 2.44-fold risk of CVD mortality compared with those in the lowest quartile. In the subpopulation analysis, the association between SUA and mortality remained similar when participants were stratified by age, gender, body mass index and type of CAD. In contrast, we found a significant interaction with estimated glomerular filtration rate (eGFR). There was a stronger association between SUA and the risk of all-cause and CVD mortality among patients with an eGFR ≥60 ml/min/1.73 m2, but no significant association was found in the population with an eGFR <60 ml/min/1.73 m2.
  
  
  
  Elevated SUA levels were positively associated with an increased risk of all-cause and CVD mortality among CAD patients.
authors.affiliation: Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ding
authors.initials: D
authors.lastname: Ding
authors.forename: Yunou
authors.initials: Y
authors.lastname: Yang
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.forename: Chaoqun
authors.initials: C
authors.lastname: Liu
authors.forename: Xinrui
authors.initials: X
authors.lastname: Li
authors.forename: Changjiang
authors.initials: C
authors.lastname: Hong
authors.forename: Wenhua
authors.initials: W
authors.lastname: Ling
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002681:China; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000208:ethnology / Q000401:mortality*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D015996:Survival Rate; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid