title: Breakable mesoporous silica nanoparticles for targeted drug delivery.
abstract: "Pop goes the particle". Here we report on the preparation of redox responsive mesoporous organo-silica nanoparticles containing disulfide (S-S) bridges (ss-NPs) that, even upon the exohedral grafting of targeting ligands, retained their ability to undergo structural degradation, and increase their local release activity when exposed to a reducing agent. This degradation could be observed also inside glioma C6 cancer cells. Moreover, when anticancer drug-loaded pristine and derivatized ss-NPs were fed to glioma C6 cells, the responsive hybrids were more effective in their cytotoxic action compared to non-breakable particles. The possibility of tailoring the surface functionalization of this hybrid, yet preserving its self-destructive behavior and enhanced drug delivery properties, paves the way for the development of effective biodegradable materials for in vivo targeted drug delivery.
authors.affiliation: Laboratoire de Chimie et des Biomatériaux Supramoléculaires, Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, 8 allée Gaspard Monge, 67083 Strasbourg, France. lm690@cam.ac.uk.
authors.forename: Laura
authors.initials: L
authors.lastname: Maggini
authors.affiliation: Laboratoire de Chimie et des Biomatériaux Supramoléculaires, Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, 8 allée Gaspard Monge, 67083 Strasbourg, France. lm690@cam.ac.uk.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Cabrera
authors.affiliation: Laboratoire de Chimie et des Biomatériaux Supramoléculaires, Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, 8 allée Gaspard Monge, 67083 Strasbourg, France. lm690@cam.ac.uk.
authors.forename: Amparo
authors.initials: A
authors.lastname: Ruiz-Carretero
authors.affiliation: Laboratoire de Chimie et des Biomatériaux Supramoléculaires, Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, 8 allée Gaspard Monge, 67083 Strasbourg, France. lm690@cam.ac.uk.
authors.forename: Eko A
authors.initials: EA
authors.lastname: Prasetyanto
authors.affiliation: Institut Hospitalo-Universitaire de Strasbourg (IHU), 1 place de l'Hôpital, 67091 Strasbourg, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Robinet
authors.affiliation: Laboratoire de Chimie et des Biomatériaux Supramoléculaires, Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, 8 allée Gaspard Monge, 67083 Strasbourg, France. lm690@cam.ac.uk and Institut für Nanotechnologie (INT) - Building 640, Karlsruhe Institute of Technology (KIT) - Campus Nord, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
authors.forename: Luisa
authors.initials: L
authors.lastname: De Cola
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D004220:Disulfides / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction / Q000187:drug effects; D010316:Particle Size; D016062:Porosity; D019163:Reducing Agents / Q000494:pharmacology; D012822:Silicon Dioxide / Q000737:chemistry*; D000077204:Temozolomide
chemical_list: D000970:Antineoplastic Agents; D004220:Disulfides; D004337:Drug Carriers; D019163:Reducing Agents; D012822:Silicon Dioxide; D003606:Dacarbazine; D000077204:Temozolomide