title: Comparison of Subconjunctival Mitomycin C and 5-Fluorouracil Injection for Needle Revision of Early Failed Trabeculectomy Blebs.
abstract: Background. To compare the efficacy of needle revision with 5-fluorouracil (5-FU) and mitomycin C (MMC) on dysfunctional filtration blebs shortly after trabeculectomy. Methods. It is a prospective randomized study comparing needle revision augmented with MMC or 5-FU for failed trabeculectomy blebs. Results. To date 71 patients (75 eyes) have been enrolled, 40 eyes in the MMC group and 35 in the 5-FU group. 68 patients (72 eyes) have completed 12-month follow-up, 38 eyes in the MMC group and 34 in the 5-FU group. The mean IOP before and that after needle revision in the MMC group were 26.5 ± 4.3 mmHg and 11.3 ± 3.4 mmHg, respectively (P < 0.05), and in the 5-FU group were 27.1 ± 3.8 mmHg and 10.9 ± 3.4 mmHg, respectively (P < 0.05). At 12-month follow-up, complete success rates were 57.5% for MMC group and 34.3% for 5-FU group (P = 0.042; log-rank test) and 75% and 60% (P = 0.145; log-rank test), respectively, for the qualified success. Complication rates between the two groups were not statistically different (P > 0.05). Conclusions. Needle revision and subconjunctival MMC injection were more effective than needling and subconjunctival 5-FU injection for early dysfunctional filtration blebs after trabeculectomies.
authors.affiliation: The Second People's Hospital of Jinan, No. 148 Jingyi Road, Jinan 250001, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: The Second People's Hospital of Jinan, No. 148 Jingyi Road, Jinan 250001, China.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Wang
authors.affiliation: The Second People's Hospital of Jinan, No. 148 Jingyi Road, Jinan 250001, China.
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Zhang
authors.affiliation: The Second People's Hospital of Jinan, No. 148 Jingyi Road, Jinan 250001, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tao
authors.affiliation: The Second People's Hospital of Jinan, No. 148 Jingyi Road, Jinan 250001, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun