title: Application of DPD in the design of polymeric nano-micelles as drug carriers.
abstract: Developing new drug carrier systems are of a great importance in the treatment approach for a wide range of diseases. The simulation techniques can be valuable for decreasing the time and cost of developing novel drug carriers. Among the simulation methods there are a vast number of studies using dissipative particle dynamics (DPD) method for the prediction of different aspects of polymeric nano-micelles for encapsulating drugs. Here, we reviewed the results of the studies employing DPD for the simulation of drug loading and release in different polymeric micelles carriers. In some cases the simulation results were compared with the experimental results by the authors that were demonstrated the reliability of the DPD predictions.
authors.affiliation: Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ramezani
authors.affiliation: Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: shamsaraj@mums.ac.ir.
authors.forename: Jamal
authors.initials: J
authors.lastname: Shamsara
mesh_terms: D004337:Drug Carriers / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D011108:Polymers / Q000737:chemistry* / Q000627:therapeutic use; D013499:Surface Properties; D013816:Thermodynamics
chemical_list: D004337:Drug Carriers; D008823:Micelles; D011108:Polymers
keywords: Dissipative particle dynamics; Drug delivery; Drug loading; Drug release; Nano-micelles; Polymeric micelles