title: Comparison of Formulas Based on Lipid Emulsions of Olive Oil, Soybean Oil, or Several Oils for Parenteral Nutrition: A Systematic Review and Meta-Analysis.
abstract: Many studies have reported that olive oil-based lipid emulsion (LE) formulas of soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) may be a viable alternative for parenteral nutrition. However, some randomized controlled clinical trials (RCTs) have raised concerns regarding the nutritional benefits and safety of SMOFs. We searched principally the MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Scopus, EMBASE, and Cochrane Central Register of Controlled Trials databases from inception to March 2014 for the relevant literature and conducted a meta-analysis of 15 selected RCTs that 1) compared either olive oil- or SMOF-based LEs with soybean oil-based LEs and 2) reported plasma concentrations of α-tocopherol, oleic acid, and ω-6 (n-6) and ω-3 (n-3) long-chain polyunsaturated fatty acids (PUFAs) and liver concentrations of total bilirubin and the enzymes alanine transaminase, aspartate transaminase, alkaline phosphatase, and γ-glutamyl transferase. The meta-analysis suggested that SMOF-based LEs were associated with higher plasma concentrations of plasma α-tocopherol, oleic acid, and the ω-3 PUFAs eicosapentaenoic and docosahexaenoic acid. Olive oil- and SMOF-based LEs correlated with lower plasma concentrations of long-chain ω-6 PUFAs and were similar to soybean oil-based LEs with regard to their effects on liver function indicators. In summary, olive oil- and SMOF-based LEs have nutritional advantages over soybean oil-based LEs and are similarly safe. However, their performance in clinical settings requires further investigation.
authors.affiliation: Departments of Clinical Nutrition, Unit for Evidence-Based Medicine, Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Dai
authors.affiliation: Neurology.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Sun
authors.affiliation: Nutrition and Food Hygiene, and Unit for Evidence-Based Medicine, Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Meng-Ying
authors.initials: MY
authors.lastname: Li
authors.affiliation: Departments of Clinical Nutrition, Nutrition and Food Hygiene, and.
authors.forename: Cui-Ling
authors.initials: CL
authors.lastname: Ding
authors.affiliation: Departments of Clinical Nutrition, Digital Center, Xi'jing Hospital, Fourth Military Medical University, Xi'an, China; and.
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Su
authors.affiliation: Departments of Clinical Nutrition.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Sun
authors.affiliation: Departments of Clinical Nutrition.
authors.forename: Sen-Hai
authors.initials: SH
authors.lastname: Xue
authors.affiliation: Departments of Clinical Nutrition.
authors.forename: Feng
authors.initials: F
authors.lastname: Yan
authors.affiliation: Departments of Clinical Nutrition, laohai800@qq.com.
authors.forename: Chang-Hai
authors.initials: CH
authors.lastname: Zhao
authors.affiliation: Unit for Evidence-Based Medicine, Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China laohai800@qq.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
mesh_terms: D003677:Deficiency Diseases / Q000097:blood / Q000517:prevention & control*; D019317:Evidence-Based Medicine; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects / Q000627:therapeutic use*; D005228:Fatty Acids, Essential / Q000009:adverse effects / Q000097:blood / Q000172:deficiency / Q000627:therapeutic use*; D005395:Fish Oils / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D000069463:Olive Oil / Q000009:adverse effects / Q000627:therapeutic use*; D010288:Parenteral Nutrition / Q000009:adverse effects / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D013024:Soybean Oil / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D005217:Fat Emulsions, Intravenous; D005228:Fatty Acids, Essential; D005395:Fish Oils; D000069463:Olive Oil; D013024:Soybean Oil
keywords: SMOF; lipid emulsion; meta-analysis; olive oil; parenteral nutrition