title: Multiple cranial neuropathies following zoledronic acid infusion: a relationship? Clinical features and pathogenic discussion concerning a case.
abstract: The widespread use of bisphosphonates, especially in osteoporosis, has led to a greater number of reports of side effects. We describe for the first time a case of a 75-year-old female patient with a history of indolent sicca syndrome who developed multiple cranial neuropathies after zoledronic acid infusion. In this case, the elimination of the main causes of multiple cranial neuropathies, the chronology with zoledronic acid infusion, the absence of secondary complications of the Sjögren's syndrome, reported cases of similar peripheral nerve injuries with interferon infusions, the spontaneous remission of this multiple cranial neuropathy in parallel with the induced flu-like syndrome, argue for its iatrogenic origin, probably by a great release of inflammatory mediators in this particular background of primary Sjögren's syndrome.
authors.affiliation: Department of Internal Medicine and Clinical Immunology, CHU de Caen, Avenue de la Côte de Nacre, Caen, 14033 Cedex 09, France.
authors.forename: S
authors.identifier: 0000-0001-8887-3233
authors.initials: S
authors.lastname: Deshayes
authors.affiliation: Department of Internal Medicine and Clinical Immunology, CHU de Caen, Avenue de la Côte de Nacre, Caen, 14033 Cedex 09, France.
authors.forename: N
authors.initials: N
authors.lastname: Martin Silva
authors.affiliation: Department of Neurology, CHU de Caen, Caen, F-14000, France.
authors.forename: J
authors.initials: J
authors.lastname: Cogez
authors.affiliation: Department of Internal Medicine and Clinical Immunology, CHU de Caen, Avenue de la Côte de Nacre, Caen, 14033 Cedex 09, France.
authors.forename: A
authors.initials: A
authors.lastname: Baldolli
authors.affiliation: Department of Pharmacovigilance, CHU de Caen, Caen, F-14000, France.
authors.forename: S
authors.initials: S
authors.lastname: Fedrizzi
authors.affiliation: Department of Internal Medicine and Clinical Immunology, CHU de Caen, Avenue de la Côte de Nacre, Caen, 14033 Cedex 09, France.
authors.forename: B
authors.initials: B
authors.lastname: Bienvenu
authors.affiliation: Department of Internal Medicine and Clinical Immunology, CHU de Caen, Avenue de la Côte de Nacre, Caen, 14033 Cedex 09, France. aouba-a@chu-caen.fr.
authors.forename: A
authors.initials: A
authors.lastname: Aouba
mesh_terms: D000368:Aged; D003389:Cranial Nerve Diseases / Q000139:chemically induced*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D012859:Sjogren's Syndrome / Q000188:drug therapy*; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid
keywords: Bisphosphonates; Iatrogenic nerve toxicity; Multiple cranial neuropathies; Sjögren’s syndrome; Zoledronic acid