title: Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research: National Heart, Lung, and Blood Institute Working Group.
abstract: Point-of-care technologies (POC or POCT) are enabling innovative cardiovascular diagnostics that promise to improve patient care across diverse clinical settings. The National Heart, Lung, and Blood Institute convened a working group to discuss POCT in cardiovascular medicine. The multidisciplinary working group, which included clinicians, scientists, engineers, device manufacturers, regulatory officials, and program staff, reviewed the state of the POCT field; discussed opportunities for POCT to improve cardiovascular care, realize the promise of precision medicine, and advance the clinical research enterprise; and identified barriers facing translation and integration of POCT with existing clinical systems. A POCT development roadmap emerged to guide multidisciplinary teams of biomarker scientists, technologists, health care providers, and clinical trialists as they: 1) formulate needs assessments; 2) define device design specifications; 3) develop component technologies and integrated systems; 4) perform iterative pilot testing; and 5) conduct rigorous prospective clinical testing to ensure that POCT solutions have substantial effects on cardiovascular care.
authors.affiliation: Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Kevin
authors.initials: K
authors.lastname: King
authors.affiliation: Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California.
authors.forename: Luanda P
authors.initials: LP
authors.lastname: Grazette
authors.affiliation: Office of Science Policy, Office of the Director, National Institutes of Health, Bethesda, Maryland.
authors.forename: Dina N
authors.initials: DN
authors.lastname: Paltoo
authors.affiliation: Departments of Bioengineering and Chemistry, Rice University, Houston, Texas.
authors.forename: John T
authors.initials: JT
authors.lastname: McDevitt
authors.affiliation: Department of Biomedical Engineering, Columbia University, New York, New York.
authors.forename: Samuel K
authors.initials: SK
authors.lastname: Sia
authors.affiliation: Scripps Translational Science Institute, La Jolla, California.
authors.forename: Paddy M
authors.initials: PM
authors.lastname: Barrett
authors.affiliation: Hennepin County Medical Center and University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, Minnesota.
authors.forename: Fred S
authors.initials: FS
authors.lastname: Apple
authors.affiliation: Sinai Hospital, Center for Thrombosis Research, Sinai Hospital, Baltimore, Maryland.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Gurbel
authors.affiliation: Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Ralph
authors.initials: R
authors.lastname: Weissleder
authors.affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Hilary
authors.initials: H
authors.lastname: Leeds
authors.affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Erin J
authors.initials: EJ
authors.lastname: Iturriaga
authors.affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Anupama
authors.initials: A
authors.lastname: Rao
authors.affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Bishow
authors.initials: B
authors.lastname: Adhikari
authors.affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Patrice
authors.initials: P
authors.lastname: Desvigne-Nickens
authors.affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Zorina S
authors.initials: ZS
authors.lastname: Galis
authors.affiliation: Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Peter
authors.initials: P
authors.lastname: Libby
keywords: biomarkers; clinical trials; precision medicine