title: Renal tubular acidosis type 4 in pregnancy.
abstract: We describe the clinical course of renal tubular acidosis (RTA) type 4 in pregnancy, which has not been previously published. Renal tubular acidosis type 4 is a condition associated with increased urinary ammonia secondary to hypoaldosteronism or pseudohypoaldosteronism. Pregnancy may worsen the hyperkalaemia and acidosis of renal tubular acidosis type 4, possibly through an antialdosterone effect. We advise regular monitoring of potassium and pH throughout pregnancy to ensure safe levels are maintained.
authors.affiliation: Hammersmith Hospital, London, UK.
authors.forename: Adam Daniel
authors.initials: AD
authors.lastname: Jakes
authors.affiliation: Ealing Hospital, London, UK.
authors.forename: Kevin
authors.initials: K
authors.lastname: Baynes
authors.affiliation: Women's Directorate Office, Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: Catherine
authors.initials: C
authors.lastname: Nelson-Piercy
mesh_terms: D000136:Acid-Base Equilibrium; D000141:Acidosis, Renal Tubular / Q000150:complications; D000328:Adult; D000450:Aldosterone / Q000378:metabolism*; D000641:Ammonia / Q000652:urine; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006947:Hyperkalemia / Q000150:complications; D006994:Hypoaldosteronism / Q000150:complications*; D007674:Kidney Diseases / Q000150:complications* / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D011188:Potassium / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*
chemical_list: D000450:Aldosterone; D000641:Ammonia; D011188:Potassium