title: Cancer prevention in HIV-infected populations.
abstract: People living with human immunodeficiency virus (HIV) are living longer since the advent of effective combined antiretroviral therapy (cART). While cART substantially decreases the risk of developing some cancers, HIV-infected individuals remain at high risk for Kaposi sarcoma, lymphoma, and several solid tumors. Currently HIV-infected patients represent an aging group, and malignancies have become a leading cause of morbidity and mortality. Tailored cancer-prevention strategies are needed for this population. In this review we describe the etiologic agents and pathogenesis of common malignancies in the setting of HIV, as well as current evidence for cancer prevention strategies and screening programs.
authors.affiliation: HIV & AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Priscila H
authors.initials: PH
authors.lastname: Goncalves
authors.affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Jairo M
authors.initials: JM
authors.lastname: Montezuma-Rusca
authors.affiliation: HIV & AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Yarchoan
authors.affiliation: HIV & AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: uldrickts@mail.nih.gov.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Uldrick
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D060085:Coinfection; D055088:Early Detection of Cancer; D020031:Epstein-Barr Virus Infections / Q000150:complications; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D030361:Papillomavirus Infections / Q000150:complications; D053918:Papillomavirus Vaccines / Q000627:therapeutic use; D012907:Smoking / Q000009:adverse effects; D016540:Smoking Cessation; D013472:Sunlight / Q000009:adverse effects; D013473:Sunscreening Agents / Q000627:therapeutic use; D014766:Viremia / Q000276:immunology
chemical_list: D044966:Anti-Retroviral Agents; D053918:Papillomavirus Vaccines; D013473:Sunscreening Agents
keywords: AIDS-related lymphoma; HIV; HPV vaccines; Kaposi sarcoma; Neoplasms