title: Kinetic analysis of RNA editing of Newcastle disease virus P gene in the early period of infection.
abstract: As a paramyxovirus, Newcastle disease virus (NDV) has the ability to edit its P (phosphoprotein) gene to synthesize three kinds of viral protein (P, V and W). It is technically very difficult to differentiate P, V and W mRNAs, and little was known about NDV regulation of RNA-editing frequency. To investigate the rules of NDV RNA editing, the ratio of the P gene-derived transcripts (P, V and W) was determined by sequencing at different time points post-infection. The results showed unstable ratio of V and W mRNA at different time points, and the frequency of NDV editing was significantly increased at the early period of infection (P
  
  
  BACKGROUND
  Newcastle disease virus; phosphoprotein; RNA editing; G insertion.
authors.forename: X
authors.initials: X
authors.lastname: Qiu
authors.forename: Q
authors.initials: Q
authors.lastname: Fu
authors.forename: C
authors.initials: C
authors.lastname: Meng
authors.forename: S
authors.initials: S
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhan
authors.forename: L
authors.initials: L
authors.lastname: Dong
authors.forename: T
authors.initials: T
authors.lastname: Ren
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: L
authors.initials: L
authors.lastname: Tan
authors.forename: C
authors.initials: C
authors.lastname: Song
authors.forename: X
authors.initials: X
authors.lastname: Han
authors.forename: C
authors.initials: C
authors.lastname: Ding
mesh_terms: D000818:Animals; D002645:Chickens; D007700:Kinetics; D009521:Newcastle Disease / Q000821:virology*; D009522:Newcastle disease virus / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D010750:Phosphoproteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D011201:Poultry Diseases / Q000821:virology*; D017393:RNA Editing; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: D010750:Phosphoproteins; D014764:Viral Proteins