title: Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice.
abstract: Methamphetamine (METH) abuse is a serious social and health problem worldwide. At present, there are no effective medications to treat METH addiction. Here, we report that aggregated single-walled carbon nanotubes (aSWNTs) significantly inhibited METH self-administration, METH-induced conditioned place preference and METH- or cue-induced relapse to drug-seeking behaviour in mice. The use of aSWNTs alone did not significantly alter the mesolimbic dopamine system, whereas pretreatment with aSWNTs attenuated METH-induced increases in extracellular dopamine in the ventral striatum. Electrochemical assays suggest that aSWNTs facilitated dopamine oxidation. In addition, aSWNTs attenuated METH-induced increases in tyrosine hydroxylase or synaptic protein expression. These findings suggest that aSWNTs may have therapeutic effects for treatment of METH addiction by oxidation of METH-enhanced extracellular dopamine in the striatum.
authors.affiliation: CAS Center for Excellence in Nanoscience, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Xue
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Yang
authors.affiliation: Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: He
authors.affiliation: CAS Center for Excellence in Nanoscience, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing 100190, China.|CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Li-Sha
authors.initials: LS
authors.lastname: Yu
authors.affiliation: Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Bi
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Zhu
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Yue-Yang
authors.initials: YY
authors.lastname: Liu
authors.affiliation: Department of Biopharmaceutical Information, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Rong-Wu
authors.initials: RW
authors.lastname: Xiang
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Yang
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Fan
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Wang
authors.affiliation: Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Qi
authors.affiliation: State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Zhang
authors.affiliation: CAS Center for Excellence in Nanoscience, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing 100190, China.|CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Tuo
authors.initials: T
authors.lastname: Wei
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.affiliation: CAS Center for Excellence in Nanoscience, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing 100190, China.|CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Guang-Lu
authors.initials: GL
authors.lastname: Ge
authors.affiliation: Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.
authors.forename: Zheng-Xiong
authors.initials: ZX
authors.lastname: Xi
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Chun-Fu
authors.initials: CF
authors.lastname: Wu
authors.affiliation: CAS Center for Excellence in Nanoscience, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing 100190, China.|CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003342:Corpus Striatum / Q000737:chemistry / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000187:drug effects* / Q000378:metabolism; D004435:Eating / Q000187:drug effects; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D037742:Nanotubes, Carbon; D011485:Protein Binding; D014446:Tyrosine 3-Monooxygenase / Q000187:drug effects / Q000378:metabolism
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D037742:Nanotubes, Carbon; D008694:Methamphetamine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine