title: The Role of Dysregulated MicroRNA Expression in Lung Cancer.
abstract: MicroRNAs (miRNAs) are a class of small single-stranded non-protein-coding RNAs that play important regulatory roles in many cellular processes including cell proliferation, differentiation, growth control, and apoptosis. They regulate gene expression on the posttranscriptional level by translational repression, mRNA cleavage, or mRNA degradation in various physiological and pathological processes. In addition, some miRNAs can function as oncogenes or tumor suppressors, so they can regulate several genes that play important roles in tumorigenesis. It was found that miRNAs are directly involved in many types of cancer, including lung cancer. Lung cancer is the leading cause of cancer mortality worldwide with a substantially low survival rate. In this work, we summarize recent findings related to miRNAs mechanisms of action and the role of their dysregulated expression in lung tumorigenesis. We describe the most important miRNAs involved in lung cancer development and targets of their activity. The understanding of the miRNA regulation in cancer may help better understand the molecular mechanisms of tumorigenesis and their importance in cancerous transformation.
authors.affiliation: Division of Molecular Medicine, Biomedical Center Martin, Comenius University in Bratislava, Mala Hora 4/C, 03601, Martin, Slovakia.
authors.forename: M
authors.initials: M
authors.lastname: Krutakova
authors.affiliation: Division of Molecular Medicine, Biomedical Center Martin, Comenius University in Bratislava, Mala Hora 4/C, 03601, Martin, Slovakia.
authors.forename: M
authors.initials: M
authors.lastname: Sarlinova
authors.affiliation: Department of Medical Biochemistry, Comenius University in Bratislava, Mala Hora 4/D, 03601, Martin, Slovakia.
authors.forename: T
authors.initials: T
authors.lastname: Matakova
authors.affiliation: Clinic of Thoracic Surgery and University Hospital Martin, Comenius University in Bratislava, Kollárova 2, 03601, Martin, Slovakia.
authors.forename: A
authors.initials: A
authors.lastname: Dzian
authors.affiliation: Clinic of Thoracic Surgery and University Hospital Martin, Comenius University in Bratislava, Kollárova 2, 03601, Martin, Slovakia.
authors.forename: J
authors.initials: J
authors.lastname: Hamzik
authors.affiliation: Department of Medical Biology, Comenius University in Bratislava, Mala Hora 4/A, 03601, Martin, Slovakia.
authors.forename: M
authors.initials: M
authors.lastname: Pec
authors.affiliation: Clinic of Pediatrics, Central Military Hospital, Generala Milosa Vesela 21, 03426, Ruzomberok, Slovakia.
authors.forename: S
authors.initials: S
authors.lastname: Javorkova
authors.affiliation: Division of Molecular Medicine, Biomedical Center Martin, Comenius University in Bratislava, Mala Hora 4/C, 03601, Martin, Slovakia. halasova@jfmed.uniba.sk.|Department of Medical Biology, Comenius University in Bratislava, Mala Hora 4/A, 03601, Martin, Slovakia. halasova@jfmed.uniba.sk.
authors.forename: E
authors.initials: E
authors.lastname: Halasova
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D009857:Oncogenes / Q000235:genetics*
keywords: Cancerogenesis; Lung cancer; Microrna; Oncogenes; Tumor suppressors