title: Association Between Polymorphism rs678653 in Human Cyclin D1 Gene (CCND1) and Susceptibility to Cancer: A Meta-Analysis.
abstract: BACKGROUND
  To assess the association between polymorphism rs678653 in human Cyclin D1 gene (CCND1) and the risk of cancer.
  
  
  METHODS
  Multiple biomedical databases were systematically searched. Pooled odds ratios (OR) and 95% confidence intervals (95% CIs) were calculated in the appropriate model.
  
  
  RESULTS
  In total, 17 case-control studies from 14 articles were included. When combing all available data, no significant association of rs678653 with cancer risk was observed under different genetic models. Stratification by ethnicity also indicated that rs678653 was not correlated with cancer risk in Taiwanese or Indian populations. When stratified by cancer type, no significant association was found between polymorphism rs678653 and digestive tract cancer, head and neck cancer, and gynecological cancer risk.
  
  
  CONCLUSIONS
  Our comprehensive meta-analysis suggests that the polymorphism rs678653 in CCND1 has no association with cancer risk in different population and disease contexts, indicating that CCND1 rs678653 does not serve a significant biological function in predicting cancer risk.
authors.affiliation: Department of Tumor Biological Treatment, The third Affiliated Hospital, Soochow University, Suzhou, Jiangsu, China (mainland).
authors.forename: Xichao
authors.initials: X
authors.lastname: Dai
authors.affiliation: Department of Oncology, Subei People's Hospital of Jiangsu Province, Clinical Medical Medical College of Yangzhou University, Suzhou, Jiangsu, China (mainland).
authors.forename: Xizhi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Subei People's Hospital of Jiangsu Province, Clinical Medical Medical College of Yangzhou University, Suzhou, Jiangsu, China (mainland).
authors.forename: Buhai
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Oncology, Subei People's Hospital of Jiangsu Province, Clinical Medical Medical College of Yangzhou University, Suzhou, Jiangsu, China (mainland).
authors.forename: Chaomin
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Suzhou, Jiangsu, China (mainland).
authors.forename: Jingting
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Suzhou, Jiangsu, China (mainland).
authors.forename: Changping
authors.initials: C
authors.lastname: Wu
mesh_terms: D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013624:Taiwan
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1