title: Targeting Plasmodium Metabolism to Improve Antimalarial Drug Design.
abstract: Malaria is one of the main infectious diseases in tropical developing countries and represents high morbidity and mortality rates nowadays. The principal etiological agent P. falciparum is transmitted through the bite of the female Anopheles mosquito. The issue has escalated due to the emergence of resistant strains to most of the antimalarials used for the treatment including Chloroquine, Sulfadoxine-Pyrimethamine, and recently Artemisinin derivatives, which has led to diminished effectiveness and by consequence increased the severity of epidemic outbreaks. Due to the lack of effective compounds to treat these drug-resistant strains, the discovery or development of novel anti-malaria drugs is important. In this context, one strategy has been to find inhibitors of enzymes, which play an important role for parasite survival. Today, promising results have been obtained in this regard, involving the entire P. falciparum metabolism. These inhibitors could serve as leads in the search of a new chemotherapy against malaria. This review focuses on the achievements in recent years with regard to inhibition of enzymes used as targets for drug design against malaria.
authors.forename: Claudia
authors.initials: C
authors.lastname: Avitia-Domínguez
authors.forename: Erick
authors.initials: E
authors.lastname: Sierra-Campos
authors.forename: Irene
authors.initials: I
authors.lastname: Betancourt-Conde
authors.forename: Miriam
authors.initials: M
authors.lastname: Aguirre-Raudry
authors.forename: Alejandra
authors.initials: A
authors.lastname: Vázquez-Raygoza
authors.forename: Artemisa
authors.initials: A
authors.lastname: Luevano-De la Cruz
authors.forename: Alejandro
authors.initials: A
authors.lastname: Favela-Candia
authors.forename: Marie
authors.initials: M
authors.lastname: Sarabia-Sanchez
authors.forename: Lluvia
authors.initials: L
authors.lastname: Ríos-Soto
authors.forename: Edna
authors.initials: E
authors.lastname: Méndez-Hernández
authors.forename: Jorge
authors.initials: J
authors.lastname: Cisneros-Martínez
authors.forename: Marcelo Gómez
authors.initials: MG
authors.lastname: Palacio-Gastélum
authors.forename: Mónica
authors.initials: M
authors.lastname: Valdez-Solana
authors.forename: Jessica
authors.initials: J
authors.lastname: Hernández-Rivera
authors.forename: Jaime
authors.initials: J
authors.lastname: De Lira-Sánchez
authors.forename: Mara
authors.initials: M
authors.lastname: Campos-Almazán
authors.affiliation: Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango, Av. Universidad y Fanny Anitua S/N, Durango. Dgo. México, C.P. 34000. atellez@ujed.mx.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Téllez-Valencia
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*
chemical_list: D000962:Antimalarials