title: Histiocytosis with mixed cell populations.
abstract: Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) are thought to originate from a common stem cell precursor, with divergent differentiation under different microenvironmental conditions. We describe an exceptional case of multiple cutaneous lesions in a 10-year-old boy, in which the coexistence of both LCH and JXG cell populations is found in every single lesion. The presence of Birbeck granules and CD207 (langerin) immunostaining in the LCH component would argue against the diagnosis of indeterminate cell histiocytosis (ICH). This unique case gives additional support to the hypothesis of a potentially common histogenesis for LCH and JXG.
authors.affiliation: Department of Dermatology, Hospital Clínico Universitario, Valencia, Spain.|School of Medicine, University of Valencia, Valencia, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Martín
authors.affiliation: Department of Dermatology, Hospital Clínico Universitario, Valencia, Spain.|School of Medicine, University of Valencia, Valencia, Spain.
authors.forename: Esperanza
authors.initials: E
authors.lastname: Jordá
authors.affiliation: Department of Dermatology, Hospital Clínico Universitario, Valencia, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martín-Gorgojo
authors.affiliation: Department of Dermatology, Hospital Clínico Universitario, Valencia, Spain.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Beteta
authors.affiliation: Department of Pathology, Hospital Clínico Universitario, Valencia, Spain.|School of Medicine, University of Valencia, Valencia, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Monteagudo
mesh_terms: D015703:Antigens, CD / Q000378:metabolism*; D002648:Child; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000378:metabolism / Q000473:pathology; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism*; D008297:Male; D037241:Mannose-Binding Lectins / Q000378:metabolism*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D014972:Xanthogranuloma, Juvenile / Q000150:complications / Q000378:metabolism / Q000473:pathology
chemical_list: D015703:Antigens, CD; C121916:CD207 protein, human; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins
keywords: histiocytosis; histopathology; indeterminate cell histiocytosis; juvenile xantogranuloma; langerhans cell histiocytosis