title: Atherosclerosis--do we know enough already to prevent it?
abstract: In this review, we have briefly summarized the characteristics of lipids and lipoproteins and the atherosclerotic process. The development of atherosclerosis is a continuous process that involves numerous cellular and acellular processes that influence the behavior of each other. These include oxidative stress, lipoprotein modifications, macrophage polarization, macrophage lipid accumulation, generation of pro- and anti-inflammatory components, calcification, cellular growth and proliferation, and plaque rupture. The precise role(s) of many of these are unknown. Understanding the events at each particular stage might shed more light onto the process as a whole and could potentially reveal targets for intervention. Therapeutic modalities that work at one stage may have little to no influence on other stages of the disease.
authors.affiliation: Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, United States.
authors.forename: Chandrakala
authors.initials: C
authors.lastname: Aluganti Narasimhulu
authors.affiliation: Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, United States.
authors.forename: Irene
authors.initials: I
authors.lastname: Fernandez-Ruiz
authors.affiliation: Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, United States.
authors.forename: Krithika
authors.initials: K
authors.lastname: Selvarajan
authors.affiliation: Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, United States.
authors.forename: Xeuting
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, United States.
authors.forename: Bhaswati
authors.initials: B
authors.lastname: Sengupta
authors.affiliation: Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, United States.
authors.forename: Aladdin
authors.initials: A
authors.lastname: Riad
authors.affiliation: Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, United States. Electronic address: spartha@ucf.edu.
authors.forename: Sampath
authors.initials: S
authors.lastname: Parthasarathy
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism* / Q000473:pathology* / Q000517:prevention & control; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D008055:Lipids / Q000502:physiology; D008074:Lipoproteins / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology
chemical_list: D008055:Lipids; D008074:Lipoproteins