title: Comparison of the effects of long-term pimobendan and benazepril administration in normal cats.
abstract: Pimobendan (PIMO) can cause adverse effects, such as mitral valve degeneration, in dogs; however, it is unclear whether these effects occur in cats. Therefore, we aimed to determine whether PIMO or benazepril produces adverse cardiac effects in healthy cats. This was a blinded, randomized, prospective parallel study. Twelve cats were randomly divided into two groups of six cats, namely, an angiotensin-converting-enzyme inhibitor group that received benazepril and a PIMO group. Cats were administered their respective treatments for 506 days, and we evaluated cardiac parameters, blood biochemistry and glomerular filtration rates during that time. At the end of the trial, the cats were euthanized, and histopathological examinations were performed by a pathologist who was blinded to the treatment groups. No significant changes were observed in any of the parameters measured in either of the groups. In particular, no significant cardiac lesions were observed in either of the groups. In healthy cats, neither PIMO nor benazepril appears to cause cardiac lesions, but future studies are needed to examine the effects of PIMO in cats with heart disease.
authors.affiliation: Division of Therapeutic Sciences I, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan Cho, Musashino City, Tokyo 180-8602, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Miyagawa
authors.forename: Noboru
authors.initials: N
authors.lastname: Machida
authors.forename: Noriko
authors.initials: N
authors.lastname: Toda
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Tominaga
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Takemura
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000009:adverse effects*; D001552:Benzazepines / Q000009:adverse effects*; D002319:Cardiovascular System / Q000187:drug effects*; D002415:Cats; D005260:Female; D008297:Male; D008943:Mitral Valve / Q000187:drug effects; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects*; D011446:Prospective Studies; D011724:Pyridazines / Q000009:adverse effects*; D016037:Single-Blind Method; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D001552:Benzazepines; D010726:Phosphodiesterase Inhibitors; D011724:Pyridazines; C041648:pimobendan; C044946:benazepril