title: Malignant Transformation in Glioma Steered by an Angiogenic Switch: Defining a Role for Bone Marrow-Derived Cells.
abstract: Low-grade gliomas, such as pilocytic astrocytoma and subependymoma, are often characterized as benign tumors due to their relative circumscription radiologically and typically non-aggressive biologic behavior. In contrast, low-grades that are by their nature diffusely infiltrative, such as diffuse astrocytomas and oligodendrogliomas, have the potential to transform into malignant high-grade counterparts and, given sufficient time, invariably do so. These high-grade gliomas carry very poor prognoses and are largely incurable, warranting a closer look at what causes this adverse transition. A key characteristic that distinguishes low- and high-grade gliomas is neovascularization: it is absent in low-grade gliomas, but prolific in high-grade gliomas, providing the tumor with ample blood supply for exponential growth. It has been well described in the literature that bone marrow-derived cells (BMDCs) may contribute to the angiogenic switch that is responsible for malignant transformation of low-grade gliomas. In this review, we will summarize the current literature on BMDCs and their known contribution to angiogenesis-associated tumor growth in gliomas.
authors.affiliation: Neurological Surgery, Weill Cornell Medical College.
authors.forename: Raymond
authors.initials: R
authors.lastname: Xu
authors.affiliation: Pathology, Weill Cornell Medical College.
authors.forename: David
authors.initials: D
authors.lastname: Pisapia
authors.affiliation: Neurological Surgery, Weill Cornell Medical College ; New York Presbyterian Hospital.
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Greenfield
keywords: angiogenesis; angiogenic switch; bone marrow-derived cells; gbm; glioma; high-grade glioma; low-grade glioma; malignant transformation; neovascularization; recurrent glioblastoma