title: [Combined radiation therapy and androgen deprivation in the management of prostate cancer: Where do we stand?].
abstract: Radiotherapy and androgen deprivation therapy play a major role in the management of prostate cancer. Indeed, radiotherapy and hormone therapy are combined in a neoadjuvant and concomitant setting for intermediate risk cancers but also in an adjuvant setting in high risk or locally advanced prostate cancer. The benefice of this association was suggested by preclinical studies and demonstrated later by several randomized trials. However, as these trials were conducted before the era of dose escalation the role of androgen deprivation therapy in this case is less clear. Moreover, as hormonal therapy can lead to a significant morbidity and a decrement in quality of life its indications must be carefully weighed especially in case of intermediate risk cancer witch represent a heterogeneous group with distinct prognostic subgroups.
authors.affiliation: Service de radiothérapie, centre régional d'oncologie, avenue Carabonita, 32002 Al Hoceima, Maroc. Electronic address: sara.bellefqih@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Bellefqih
authors.affiliation: Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc.
authors.forename: K
authors.initials: K
authors.lastname: Hadadi
authors.affiliation: Service de radiothérapie, centre d'oncologie Hassan-II, 8km route Jerada, 4806 Oujda, Maroc.
authors.forename: I
authors.initials: I
authors.lastname: Mezouri
authors.affiliation: Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc; Service de radiothérapie, Institut national d'oncologie, avenue Allal El Fassi, 10100 Rabat, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: Maghous
authors.affiliation: Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc; Service de radiothérapie, Institut national d'oncologie, avenue Allal El Fassi, 10100 Rabat, Maroc.
authors.forename: E
authors.initials: E
authors.lastname: Marnouche
authors.affiliation: Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc.
authors.forename: K
authors.initials: K
authors.lastname: Andaloussi
authors.affiliation: Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc.
authors.forename: M
authors.initials: M
authors.lastname: Elmarjany
authors.affiliation: Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc.
authors.forename: H
authors.initials: H
authors.lastname: Sifat
authors.affiliation: Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc.
authors.forename: H
authors.initials: H
authors.lastname: Mansouri
authors.affiliation: Service de radiothérapie, Institut national d'oncologie, avenue Allal El Fassi, 10100 Rabat, Maroc.
authors.forename: N
authors.initials: N
authors.lastname: Benjaafar
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000401:mortality / Q000628:therapy*; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant
chemical_list: D000726:Androgen Antagonists
keywords: Androgen deprivation; Cancer de la prostate; Dose escalation; Escalade de dose; Hormonothérapie; Prostate cancer; Radiotherapy; Radiothérapie