title: [The efficacy and safety of teraligen in patients with brain ischemia, stages I and II, and psychoautonomic syndrome].
abstract: OBJECTIVE
  To assess the efficacy and safety of teraligen in patients with psychoautonomic syndrome comorbid to brain ischemia.
  
  
  METHODS
  Forty-five patients, aged from 42 to 65 years (mean age 56 years), diagnosed with brain ischemia, stages I and II, with the signs of psychoautonomic syndrome were examined. Thirty-five patients received teraligen in the daily dose of 15 mg. The control group comprised 10 patients who were not treated with this drug. The duration of treatment was 60 days. Neurological status, autonomic changes, cognitive functions and mental state were assessed during the treatment. Neurophysiological examination (EEG and P300 event-related potential) were performed in the first and last visits.
  
  
  CONCLUSIONS
  The distinct positive dynamics of the decrease of psychoautonomic symptoms, cephalgic syndrome, sleep normalization as well as the improvement of cognitive function were noted. Good tolerability and no side-effects, in particular, those related to vascular disorders, were demonstrated. Clinical results were supported by the results of neurophysiological examinations. The drug can be recommended for treatment of psychoautonomic syndrome in elderly patients with brain ischemia, stages I and II.
authors.affiliation: Almazov Federal North-West Medical Research Centre, St. Petersburg.
authors.forename: E R
authors.initials: ER
authors.lastname: Barancevich
authors.affiliation: Almazov Federal North-West Medical Research Centre, St. Petersburg.
authors.forename: M S
authors.initials: MS
authors.lastname: Golovkova
authors.affiliation: Bayandin Murmansk Regional Clinical Hospital, Murmansk.
authors.forename: I A
authors.initials: IA
authors.lastname: Dzhulaj
authors.affiliation: Pavlov First Saint Petersburg State Medical University, St. Petersburg.
authors.forename: O V
authors.initials: OV
authors.lastname: Posohina
authors.affiliation: Central City Clinical Hospital, Veliky Novgorod.
authors.forename: P V
authors.initials: PV
authors.lastname: Starikov
mesh_terms: D000328:Adult; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D003071:Cognition; D018913:Event-Related Potentials, P300; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D016896:Treatment Outcome; D014291:Trimeprazine / Q000627:therapeutic use*
chemical_list: D014291:Trimeprazine