title: Tracking Down Mutations Cell by Cell.
abstract: Using somatic cell nuclear transfer, Hazen et al. (2016) examined clonally expanded single neurons for mutations and found ∼100 mutations from a variety of classes. Post-mitotic mutations in individual neurons represent an exploratory direction for finding fundamental origins of neurodegeneration.
authors.affiliation: Neuroscience Research Institute, Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106-5060, USA. Electronic address: kosik@lifesci.ucsb.edu.
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Kosik
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D005260:Female; D006801:Humans; D009154:Mutation / Q000235:genetics*; D009474:Neurons / Q000502:physiology*; D017422:Sequence Analysis, DNA