title: Expression Profiles of Endometrial Carcinoma by Integrative Analysis of TCGA Data.
abstract: BACKGROUND
  This study was to explore the expression profile of endometrial carcinoma (EC) and identify the potential molecular mechanism and therapeutic targets.
  
  
  METHODS
  Differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) were identified in EC using mRNA and miRNA sequencing data released by the Cancer Genome Atlas database; then, gene function and pathway of DEGs were analyzed based on the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway databases; finally, the transcription factors (TFs) latently regulating the DEGs and DEMs were predicted and a TF-miRNA-Gene network was then established to summarize the regulatory links between TFs, DEMs and DEGs.
  
  
  RESULTS
  One thousand five hundred and forty two upregulated and 1,885 downregulated DEGs, 34 upregulated and 12 downregulated DEMs were identified. The principal DEGs-enriched functions were cell differentiation, cell migration, and cell surface receptor signaling pathway. The DEGs-enriched cell signaling pathways including the MAPK, Wnt signaling pathway, and the p53 signaling pathway. As shown in the TF-miRNA-Gene network, TFs such as CPBP and GKLF, miRNAs such as miR-141-3p and miR-130b-3p, regulated most of DEGs and DEMs.
  
  
  CONCLUSIONS
  These results may contribute to the study of the molecular mechanism and therapeutic targets in EC, and facilitate the discovery of new biomarkers for screening, diagnosis and monitoring.
authors.affiliation: Department of Radiation Oncology, Eye and ENT Hospital, Shanghai, China.
authors.forename: Huizhen
authors.initials: H
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Ruiqin
authors.initials: R
authors.lastname: Tu
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Wenbin
authors.initials: W
authors.lastname: Tang
authors.forename: Long
authors.initials: L
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhan
authors.forename: Rongyu
authors.initials: R
authors.lastname: Zang
mesh_terms: D030541:Databases, Genetic; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods*; D053263:Gene Regulatory Networks; D006801:Humans; D000090062:Kruppel-Like Factor 4; D035683:MicroRNAs / Q000235:genetics; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; D035683:MicroRNAs; D012333:RNA, Messenger; D014157:Transcription Factors