title: Two new asterriquinols from Aspergillus sp. CBS-P-2 with anti-inflammatory activity.
abstract: Two new bisindolylbenzenoid alkaloids asterriquinol E (1) and asterriquinol F (2), together with four known compounds (3-6) were isolated from the fermentation products of the fungus Aspergillus sp. CBS-P-2. Their structures were established on the basis of extensive spectroscopic analysis, including HR-ESI-MS, UV, IR, 1D, and 2D NMR (HSQC, HMBC, and NOESY) methods. The stereochemical structure of 2 was confirmed via the CD data of the in situ formed [Rh2(OCOCF3)4] complex method. All of the isolated compounds were tested for inhibitory activity against LPS (lipopolysaccharide)-induced nitric oxide production in microglia.
authors.affiliation: a Key Laboratory of Structure-Based Drug Design ＆ Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , 110016 China.
authors.forename: Xiao
authors.initials: X
authors.lastname: An
authors.affiliation: c School of Life Sciences and Biotechnology , Dalian University , Dalian , 116622 China.
authors.forename: Bao-Min
authors.initials: BM
authors.lastname: Feng
authors.affiliation: a Key Laboratory of Structure-Based Drug Design ＆ Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , 110016 China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Structure-Based Drug Design ＆ Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , 110016 China.
authors.forename: Shao-Fei
authors.initials: SF
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Structure-Based Drug Design ＆ Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , 110016 China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Structure-Based Drug Design ＆ Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , 110016 China.
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Pei
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry*; D002681:China; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D012988:Soil Microbiology
chemical_list: D000893:Anti-Inflammatory Agents; D026121:Indole Alkaloids; D008070:Lipopolysaccharides; C000613165:asterriquinol E; C000613166:asterriquinol F; D009569:Nitric Oxide
keywords: Aspergillus sp; Asterriquinols; anti-inflammatory activity