title: Assessing the impact of a joint human-porcine intervention package for Taenia solium control: Results of a pilot study from northern Lao PDR.
abstract: Following confirmation that a remote village of approximately 300 inhabitants in northern Lao PDR was hyperendemic for the Neglected Tropical Disease Taenia solium, a pilot human-porcine therapeutic control intervention was implemented between October 2013 and November 2014. Mass drug administration with a three day albendazole 400mg protocol was offered to all eligible humans in October 2013 and March 2014. At these times, and again in October 2014, eligible village pigs received the anti-cysticercosis TSOL18 vaccination and an oral dose of oxfendazole anthelmintic at 30mg/kg, both repeated one month later. Community and individual human taeniasis prevalences were estimated via copro-antigen ELISA of volunteered human faecal samples prior to October 2013, and again in January 2015, in order to examine the short term impact of the intervention.
authors.affiliation: CSIRO, Australian Animal Health Laboratory (AAHL) Regional Programme, Geelong, Australia; Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom. Electronic address: anna.okello1@gmail.com.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Okello
authors.affiliation: International Consultant, Harare, Zimbabwe.
authors.forename: Lian
authors.initials: L
authors.lastname: Thomas
authors.affiliation: National Animal Health Laboratory, Department of Livestock and Fisheries, Ministry of Agriculture, Lao PDR.
authors.forename: Phouth
authors.initials: P
authors.lastname: Inthavong
authors.affiliation: School of Veterinary and Life Sciences, Murdoch University, Perth, Australia.
authors.forename: Amanda
authors.initials: A
authors.lastname: Ash
authors.affiliation: Department of Hygiene and Prevention, Ministry of Health, Lao PDR.
authors.forename: Boualam
authors.initials: B
authors.lastname: Khamlome
authors.affiliation: National Animal Health Laboratory, Department of Livestock and Fisheries, Ministry of Agriculture, Lao PDR.
authors.forename: Chattouphone
authors.initials: C
authors.lastname: Keokamphet
authors.affiliation: CSIRO, Australian Animal Health Laboratory (AAHL) Regional Programme, Geelong, Australia.
authors.forename: Kim
authors.initials: K
authors.lastname: Newberry
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, University of Melbourne, 250 Princes Highway, Werribee, VIC 3030, Australia.
authors.forename: Charles G
authors.initials: CG
authors.lastname: Gauci
authors.affiliation: Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium.
authors.forename: Sarah
authors.initials: S
authors.lastname: Gabriël
authors.affiliation: Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Dorny
authors.affiliation: School of Veterinary and Life Sciences, Murdoch University, Perth, Australia.
authors.forename: Rc Andrew
authors.initials: RA
authors.lastname: Thompson
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, University of Melbourne, 250 Princes Highway, Werribee, VIC 3030, Australia.
authors.forename: Marshall W
authors.initials: MW
authors.lastname: Lightowlers
authors.affiliation: CSIRO, Australian Animal Health Laboratory (AAHL) Regional Programme, Geelong, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Allen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015766:Albendazole / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use; D003551:Cysticercosis / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007812:Laos / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015995:Prevalence; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology*; D041201:Taenia solium / Q000302:isolation & purification*; D013622:Taeniasis / Q000188:drug therapy* / Q000517:prevention & control*; D014611:Vaccination
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D015766:Albendazole; C011030:oxfendazole