title: Interplay of migratory and division forces as a generic mechanism for stem cell patterns.
abstract: In many adult tissues, stem cells and differentiated cells are not homogeneously distributed: stem cells are arranged in periodic "niches," and differentiated cells are constantly produced and migrate out of these niches. In this article, we provide a general theoretical framework to study mixtures of dividing and actively migrating particles, which we apply to biological tissues. We show in particular that the interplay between the stresses arising from active cell migration and stem cell division give rise to robust stem cell patterns. The instability of the tissue leads to spatial patterns which are either steady or oscillating in time. The wavelength of the instability has an order of magnitude consistent with the biological observations. We also discuss the implications of these results for future in vitro and in vivo experiments.
authors.affiliation: Physicochimie Curie (Institut Curie/CNRS-UMR 168/UPMC), Institut Curie, Centre de Recherche, PSL Research University, 26 rue d'Ulm, 75248 Paris Cedex 05, France.|Cavendish Laboratory, 19 JJ Thompson Avenue, Cambridge CB3 0HE, United Kingdom.
authors.forename: Edouard
authors.initials: E
authors.lastname: Hannezo
authors.affiliation: Physicochimie Curie (Institut Curie/CNRS-UMR 168/UPMC), Institut Curie, Centre de Recherche, PSL Research University, 26 rue d'Ulm, 75248 Paris Cedex 05, France.|Laboratoire de Physique Théorique, CNRS-UMR 8549, Ecole Normale Supérieure, 24 Rue Lhomond, 75005 Paris, France.|Biologie Computationnelle et Quantitative, CNRS-UMR 7238, Sorbonne Universités, UPMC Paris 06, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Coucke
authors.affiliation: Physicochimie Curie (Institut Curie/CNRS-UMR 168/UPMC), Institut Curie, Centre de Recherche, PSL Research University, 26 rue d'Ulm, 75248 Paris Cedex 05, France.|ESPCI Paris-Tech, 10 rue Vauquelin, 75005 Paris, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Joanny
mesh_terms: D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D008954:Models, Biological; D013234:Stem Cells / Q000166:cytology*