title: Frequency of malignancy is high in patients admitted for a first venous thromboembolism episode: an observational study.
abstract: Patients with a cancer at time of first venous thromboembolism (VTE) have not been thoroughly analyzed. Our study aimed to (1) determine the frequency of cancer diagnosed in patients hospitalized for a first VTE episode, (2) investigate the characteristics of VTE and cancer in such patients. All consecutive adults patients hospitalized over a 6-years period for a first VTE episode in a tertiary care hospital were considered. Patients with congenital or acquired thrombophilia were excluded. Demographic, medical history, and follow up data were retrieved from medical records. 216 patients (63.6 ± 19.7 years, 63.4 % females) hospitalized for a first VTE were analyzed. Among them, 64 patients (29.6 %) had cancer, either revealed (n = 26) or already known (n = 38) at VTE diagnosis. Cancer was in an advanced stage in 26 patients (40.6 %). Patients with cancer were older and displayed a higher frequency of vena cava thrombosis, as compared to patients without cancer. VTE was more recurrent and mortality was higher in patients with cancer. Cancer occurred after VTE diagnosis in only 2 (2/127, 1.6 %) cases during a protracted follow-up of 24.1 ± 22.5 months. Overall, VTE preceded cancer diagnosis in only 3 % (2/66) of cases. Frequency of cancer is high among patients hospitalized for a first VTE. In such setting, VTE often involved unusual sites such as vena cava. In most cases, cancer was either already known or diagnosed at time of VTE, with a poor prognosis.
authors.affiliation: Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, 46 Rue Henri Huchard, 75018, Paris, France.
authors.forename: Diane
authors.initials: D
authors.lastname: Rouzaud
authors.affiliation: Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, 46 Rue Henri Huchard, 75018, Paris, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Alexandra
authors.affiliation: Département de Médecine Interne, Hôpital Saint Antoine, Université Pierre et Marie Curie, Assistance Publique Hôpitaux de Paris, Paris, France.
authors.forename: Maria
authors.initials: M
authors.lastname: Chauchard
authors.affiliation: Département d'Epidémiologie, Biostatistiques et Recherche Clinique, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, Paris, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Delon
authors.affiliation: Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, 46 Rue Henri Huchard, 75018, Paris, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Dossier
authors.affiliation: Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, 46 Rue Henri Huchard, 75018, Paris, France.
authors.forename: Tiphaine
authors.initials: T
authors.lastname: Goulenok
authors.affiliation: Département d'Epidémiologie, Biostatistiques et Recherche Clinique, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Perozziello
authors.affiliation: Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, 46 Rue Henri Huchard, 75018, Paris, France.|INSERM U1149, Paris, France.|Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases), Paris, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Papo
authors.affiliation: Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, 46 Rue Henri Huchard, 75018, Paris, France. karim.sacre@aphp.fr.|INSERM U1149, Paris, France. karim.sacre@aphp.fr.|Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases), Paris, France. karim.sacre@aphp.fr.
authors.forename: Karim
authors.initials: K
authors.lastname: Sacre
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D008297:Male; D008499:Medical Records / Q000706:statistics & numerical data; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D012008:Recurrence; D014684:Venae Cavae; D054556:Venous Thromboembolism / Q000150:complications*
keywords: Cancer; Deep venous thrombosis; Embolism