title: Post-exposure vaccination with the vaccine candidate Bacillus Calmette-Guérin ΔureC::hly induces superior protection in a mouse model of subclinical tuberculosis.
abstract: The tuberculosis vaccine BCG ΔureC::hly is the most advanced BCG replacement candidate in phase II clinical development. Here we assess the protective capacity of the construct administered to mice as homologous prime-boost vaccine prior Mycobacterium tuberculosis infection and as post-exposure vaccine. Multiple immunization did not improve the superior protection of BCG ΔureC::hly over BCG. Animals with subclinical tuberculosis were better protected when vaccinated with BCG ΔureC::hly as compared to BCG. Our findings suggest further consideration of BCG ΔureC::hly as post-exposure vaccine.
authors.affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, 10117 Berlin, Germany; National University of Singapore, Yong Loo Lin School of Medicine, Department of Microbiology and Immunology, 5 Science Drive 2, Block MD4, Level 3, Singapore 117545, Singapore.
authors.forename: Martin
authors.initials: M
authors.lastname: Gengenbacher
authors.affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Peggy
authors.initials: P
authors.lastname: Kaiser
authors.affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Schuerer
authors.affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Doris
authors.initials: D
authors.lastname: Lazar
authors.affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: kaufmann@mpiib-berlin.mpg.de.
authors.forename: Stefan H E
authors.initials: SH
authors.lastname: Kaufmann
mesh_terms: D000818:Animals; D058345:Asymptomatic Infections; D001500:BCG Vaccine / Q000008:administration & dosage / Q000276:immunology*; D001426:Bacterial Proteins / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D008807:Mice, Inbred BALB C; D009163:Mycobacterium bovis / Q000235:genetics / Q000276:immunology*; D056990:Post-Exposure Prophylaxis / Q000379:methods*; D016896:Treatment Outcome; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*
chemical_list: D001500:BCG Vaccine; D001426:Bacterial Proteins
keywords: BCG; Post-exposure vaccination; VPM1002