title: Matrix metalloproteinases as candidate biomarkers in adults with congenital heart disease.
abstract: Context Matrix metalloproteinases (MMPs) are associated with diastolic dysfunction and heart failure in acquired heart disease. Objective To investigate the role of MMPs as novel biomarkers in clinically stable adults with congenital heart disease. Methods We measured serum MMP-2, -3, -9 and tissue inhibitor of matrix metalloproteinase-1 in 425 patients and analysed the association with cardiac function and exercise capacity. Results MMP-2 was significantly associated with exercise capacity, ventilatory efficiency and left ventricular deceleration time, independently of age, sex, body surface area and NT-proBNP. Conclusion MMP-2 may provide new information in the clinical evaluation of adults with congenital heart disease.
authors.affiliation: a Department of Cardiology , Erasmus Medical Centre , Rotterdam , The Netherlands ;|b Cardiovascular Research School COEUR , Rotterdam , The Netherlands ;
authors.forename: Vivan J M
authors.initials: VJ
authors.lastname: Baggen
authors.affiliation: a Department of Cardiology , Erasmus Medical Centre , Rotterdam , The Netherlands ;|b Cardiovascular Research School COEUR , Rotterdam , The Netherlands ;
authors.forename: Jannet A
authors.initials: JA
authors.lastname: Eindhoven
authors.affiliation: a Department of Cardiology , Erasmus Medical Centre , Rotterdam , The Netherlands ;
authors.forename: Annemien E
authors.initials: AE
authors.lastname: van den Bosch
authors.affiliation: a Department of Cardiology , Erasmus Medical Centre , Rotterdam , The Netherlands ;
authors.forename: Maarten
authors.initials: M
authors.lastname: Witsenburg
authors.affiliation: a Department of Cardiology , Erasmus Medical Centre , Rotterdam , The Netherlands ;
authors.forename: Judith A A E
authors.initials: JA
authors.lastname: Cuypers
authors.affiliation: c Department of Clinical Chemistry , Erasmus Medical Centre , Rotterdam , The Netherlands ;
authors.forename: Jannette S
authors.initials: JS
authors.lastname: Langstraat
authors.affiliation: a Department of Cardiology , Erasmus Medical Centre , Rotterdam , The Netherlands ;|b Cardiovascular Research School COEUR , Rotterdam , The Netherlands ;|d Department of Clinical Epidemiology , Erasmus Medical Centre , Rotterdam , The Netherlands.
authors.forename: Eric
authors.initials: E
authors.lastname: Boersma
authors.affiliation: a Department of Cardiology , Erasmus Medical Centre , Rotterdam , The Netherlands ;
authors.forename: Jolien W
authors.initials: JW
authors.lastname: Roos-Hesselink
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood / Q000201:enzymology*; D006334:Heart Function Tests / Q000379:methods*; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D020782:Matrix Metalloproteinases / Q000097:blood*; D005082:Physical Exertion
chemical_list: D015415:Biomarkers; D020782:Matrix Metalloproteinases; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2
keywords: Cardiac function; echocardiography; exercise capacity