title: Epidemic Profile of Maternal Syphilis in China in 2013.
abstract: OBJECTIVE
  The aim of this study was to investigate the epidemiological characteristics and adverse pregnancy outcomes of pregnant women with syphilis infection in China.
  
  
  METHODS
  Data were from China's Information System of Prevention of Mother-to-Child Transmission of Syphilis Management. Women who were registered in the system and delivered in 2013 were included in the analysis.
  
  
  RESULTS
  A total of 15884 pregnant women with syphilis infection delivered in China in 2013. 79.1% of infected women attended antenatal care at or before 37 gestational weeks; however, 55.4% received no treatment or initiated the treatment after 37 gestational weeks. 14.0% of women suffered serious adverse pregnancy outcomes including stillbirth/neonatal death, preterm delivery/low birth weight, or congenital syphilis in newborns. High maternal titer (≥1 : 64) and late treatment (>37 gestational weeks)/nontreatment were significantly associated with increased risk of congenital syphilis and the adjusted ORs were 1.88 (95% CI 1.27 to 2.80) and 3.70 (95% CI 2.36 to 5.80), respectively.
  
  
  CONCLUSIONS
  Syphilis affects a great number of pregnant women in China. Large proportions of women are not detected and treated at an early pregnancy stage. Burden of adverse pregnancy outcomes is high among infected women. Comprehensive interventions still need to be strengthened to improve uptake of screening and treatment for maternal syphilis.
authors.affiliation: National Center for Women and Children's Health, China CDC, No. 12 Dahuisi Road, Haidian District, Beijing 100081, China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Dou
authors.affiliation: National Center for Women and Children's Health, China CDC, No. 12 Dahuisi Road, Haidian District, Beijing 100081, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.affiliation: National Center for Women and Children's Health, China CDC, No. 12 Dahuisi Road, Haidian District, Beijing 100081, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: National Center for Women and Children's Health, China CDC, No. 12 Dahuisi Road, Haidian District, Beijing 100081, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: National Center for Women and Children's Health, China CDC, No. 12 Dahuisi Road, Haidian District, Beijing 100081, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: National Center for Women and Children's Health, China CDC, No. 12 Dahuisi Road, Haidian District, Beijing 100081, China.
authors.forename: Min
authors.initials: M
authors.lastname: Su
authors.affiliation: National Center for Women and Children's Health, China CDC, No. 12 Dahuisi Road, Haidian District, Beijing 100081, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Jin
authors.affiliation: National Health and Family Planning Commission, No. 14 Zhichun Road, Haidian District, Beijing 100088, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Qiu
authors.affiliation: National Health and Family Planning Commission, No. 14 Zhichun Road, Haidian District, Beijing 100088, China.
authors.forename: Li
authors.initials: L
authors.lastname: Song
authors.affiliation: National Center for Women and Children's Health, China CDC, No. 12 Dahuisi Road, Haidian District, Beijing 100081, China.
authors.forename: Ailing
authors.initials: A
authors.lastname: Wang
mesh_terms: D016208:Databases, Factual; D005260:Female; D006801:Humans; D007234:Infant, Premature; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology*; D047928:Premature Birth / Q000175:diagnosis / Q000453:epidemiology*; D013587:Syphilis / Q000175:diagnosis / Q000453:epidemiology*