title: Glucocorticoids and nervous system plasticity.
abstract: Glucocorticoid and glucocorticoid receptor (GC/GR) interactions alter numerous aspects of neuronal function. These consequences (e.g., anti-inflammatory vs. pro-inflammatory) can vary depending on the duration of GC exposure or central nervous system (CNS) injury model. In this review we discuss how GC/GR interactions impact neuronal recovery after a central or peripheral nerve injury and discuss how GC exposure duration can produce divergent CNS neuronal growth responses. Finally we consider how new findings on gender specific immune cell responses after a nerve injury could intersect with GC/GR interactions to impact pain processing.
authors.affiliation: Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, OH, USA; Department of Neuroscience, Wexner Medical Center at The Ohio State University, Columbus, OH, USA.
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Madalena
authors.affiliation: Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, OH, USA; Department of Neuroscience, Wexner Medical Center at The Ohio State University, Columbus, OH, USA.
authors.forename: Jessica K
authors.identifier: 0000-0002-1210-3184
authors.initials: JK
authors.lastname: Lerch
keywords: glucocorticoids; neuropathic pain; plasticity; stress