title: The incidence rate and prevalence of pediatric type 1 diabetes mellitus (age 0-18) in the Italian region Friuli Venezia Giulia: population-based estimates through the analysis of health administrative databases.
abstract: OBJECTIVE
  The main objective of this study was to estimate the incidence rate and prevalence of pediatric type 1 diabetes mellitus (T1DM; population 0-18 years of age) in the northeastern Italian region Friuli Venezia Giulia and to characterize the subjects affected by the disease.
  
  
  METHODS
  This was a retrospective population-based study conducted through the individual-level linkage of several health administrative databases of the Friuli Venezia Giulia region. The incidence rate and prevalence were calculated in the population 0-18 years of age. Using the Mid-p exact method, 95 % confidence intervals for rates were calculated.
  
  
  RESULTS
  The incidence rate of pediatric T1DM in the years 2010-2013 was 15.8 new cases/100,000 person-years, peaking in the age class 10-14 years. The rate has increased substantially as compared with the previous regional estimate that dated back to 1993. We observed a seasonal pattern both in the date of birth of the incident cases and in the date of onset of the disease. In the region in 2013, there were 294 prevalent cases (15.1/10,000 inhabitants). Most of them had at least one glycated hemoglobin test in the year. More than 15 % had co-existing autoimmune comorbidities.
  
  
  CONCLUSIONS
  The incidence rate of pediatric T1DM in Friuli Venezia Giulia has increased in the last years, and the disease is a relevant public health issue in the region.
authors.affiliation: Servizio Epidemiologico, Direzione centrale salute, integrazione sociosanitaria, politiche sociali e famiglia, Regione autonoma Friuli Venezia Giulia, Via Pozzuolo 330, 33100, Udine, Italy. francesca.valent@regione.fvg.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Valent
authors.affiliation: Azienda per l'Assistenza Sanitaria N. 1 "Triestina", 34148, Trieste, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Candido
authors.affiliation: IRCCS materno infantile "Burlo Garofolo", 34137, Trieste, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Faleschini
authors.affiliation: Azienda Ospedaliero Universitaria di Udine, 33100, Udine, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Tonutti
authors.affiliation: Azienda per l'Assistenza Sanitaria N. 2 "Bassa Friulana-Isontina", 34170, Gorizia, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Tortul
authors.affiliation: Azienda Ospedaliero Universitaria di Udine, 33100, Udine, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Zanatta
authors.affiliation: Azienda per l'Assistenza Sanitaria N. 5 "Friuli Occidentale", 33170, Pordenone, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Zanette
authors.affiliation: Servizio Epidemiologico, Direzione centrale salute, integrazione sociosanitaria, politiche sociali e famiglia, Regione autonoma Friuli Venezia Giulia, Via Pozzuolo 330, 33100, Udine, Italy.
authors.forename: Loris
authors.initials: L
authors.lastname: Zanier
mesh_terms: D000293:Adolescent; D001327:Autoimmune Diseases / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D016208:Databases, Factual; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies
keywords: Incidence rate; Italy; Pediatric; Prevalence; Type 1 diabetes mellitus