title: Genomics in CKD: Is This the Path Forward?
abstract: Recent advances in genomics and sequencing technology have led to a better understanding of genetic risk in CKD. Genetics could account in part for racial differences in treatment response for medications including antihypertensives and immunosuppressive medications due to its correlation with ancestry. However, there is still a substantial lag between generation of this knowledge and its adoption in routine clinical care. This review summarizes the recent advances in genomics and CKD, discusses potential reasons for its underutilization, and highlights potential avenues for application of genomic information to improve clinical care and outcomes in this particularly vulnerable population.
authors.affiliation: Department of Medicine, Division of Nephrology, Icahn School of Medicine, New York, NY; Department of Population Health Science and Policy, Icahn School of Medicine, New York, NY; and Department of Medicine, Icahn School of Medicine, New York, NY.
authors.forename: Girish N
authors.initials: GN
authors.lastname: Nadkarni
authors.affiliation: Department of Medicine, Division of Nephrology, Icahn School of Medicine, New York, NY; Department of Population Health Science and Policy, Icahn School of Medicine, New York, NY; and Department of Medicine, Icahn School of Medicine, New York, NY. Electronic address: carol.horowitz@mountsinai.org.
authors.forename: Carol R
authors.initials: CR
authors.lastname: Horowitz
mesh_terms: D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000235:genetics; D023281:Genomics; D006801:Humans; D008075:Lipoproteins, HDL / Q000235:genetics; D009398:Nephrology; D010597:Pharmacogenetics; D051436:Renal Insufficiency, Chronic / Q000208:ethnology / Q000235:genetics*; D012084:Renin-Angiotensin System / Q000235:genetics; D057170:Translational Research, Biomedical
chemical_list: C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D008075:Lipoproteins, HDL
keywords: CKD; Disparities; Genetics; Genomics; Pharmacogenomics