title: Nanotechnology and Pediatric Cancer: Prevention, Diagnosis and Treatment.
abstract: Despite development of new approaches for the treatment of cancer disease, it is the second cause of mortality in world. Annually, 30000 persons die in Iran due to cancer diseases. Eighty percent of cancer patients are children which about 50% children lead to death. Given the high rate of cancer-related death, the new approaches for prevention, control, early diagnosis, and treatment of this disease seem necessary. Investigation of new strategies is the major challenge for scientists at recent century. Nanotechnology as a new scientific field with novel and small compounds utilized different fields over the past ten years especially in medicine. This science has come to the forefront in the areas of medical diagnostics, imaging, and therapeutic scheduls. Therefore, it has the potential applications for cancer detection and therapy. This review will discuss the therapeutic applications of different nano-materials in diagnosis, imaging, and delivery of therapeutic agents for the treatment of cancer with a major focus on their applications for the treatment of cancer and cancer- related diseases in children. The advancements in established nanoparticle technologies such as liposomes, polymer micelles, and functionalization regarding tumor targeting and controlled release strategies as well as drug delivery were discussed. It will also review the blood toxicity of used nanostructures.
authors.affiliation: Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran; Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Zare-Zardini
authors.affiliation: Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: A
authors.initials: A
authors.lastname: Amiri
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Shanbedi
authors.affiliation: Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Taheri-Kafrani
authors.affiliation: Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Sadri
authors.affiliation: Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Ghanizadeh
authors.affiliation: Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Neamatzadeh
authors.affiliation: Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Sheikhpour
authors.affiliation: Department of Biology, University of Science and Arts, Yazd, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Keyvani Boroujeni
authors.affiliation: Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Masoumi Dehshiri
authors.affiliation: Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Hashemi
authors.affiliation: Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: M M
authors.initials: MM
authors.lastname: Aminorroaya
authors.affiliation: Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: M R
authors.initials: MR
authors.lastname: Dehgahnzadeh
authors.affiliation: Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Sh
authors.initials: Sh
authors.lastname: Shahriari
keywords: Cancer; Children; Functionalization; Nanotechnology