title: Emerging functions of the Quaking RNA-binding proteins and link to human diseases.
abstract: RNA-binding proteins (RBPs) are essential players in RNA metabolism including key cellular processes from pre-mRNA splicing to mRNA translation. The K homology-type QUAKING RBP is emerging as a vital factor for oligodendrocytes, monocytes/macrophages, endothelial cell, and myocyte function. Interestingly, the qkI gene has now been identified as the culprit gene for a patient with intellectual disabilities and is translocated in a pediatric ganglioglioma as a fusion protein with MYB. In this review, we will focus on the emerging discoveries of the QKI proteins as well as highlight the recent advances in understanding the role of QKI in human disease pathology including myelin disorders, schizophrenia and cancer. WIREs RNA 2016, 7:399-412. doi: 10.1002/wrna.1344 For further resources related to this article, please visit the WIREs website.
authors.affiliation: Terry Fox Molecular Oncology Group, Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, Canada, H3T 1E2.
authors.forename: Lama
authors.initials: L
authors.lastname: Darbelli
authors.affiliation: Terry Fox Molecular Oncology Group, Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, Canada, H3T 1E2.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Richard
mesh_terms: D003711:Demyelinating Diseases / Q000503:physiopathology*; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D012559:Schizophrenia / Q000503:physiopathology*
chemical_list: C490832:QKI protein, human; D016601:RNA-Binding Proteins