title: Comparison of failure rates of crossing side branch with pressure vs. coronary guidewire: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to compare the failure rates of crossing side branch (SB) with pressure guidewire vs. coronary guidewire after main vessel (MV) stenting in coronary bifurcation lesions (CBL).
  
  
  BACKGROUND
  Percutaneous coronary intervention of CBL is technically difficult. The European Bifurcation Club recommends performing either fractional flow reserve (FFR) estimation of the SB or final kissing balloon inflation (FKBI) after the MV stenting when a significant SB ostial stenosis is present. Even though FFR is recommended in CBL, there is concern about SB crossing with pressure guidewire among interventionists.
  
  
  METHODS
  We undertook a comprehensive literature search to identify all relevant studies reporting the failure rates of SB crossing after MV stenting with either pressure or coronary guidewire. A random effects model was used to compare the failure rates between the two approaches.
  
  
  RESULTS
  Our search identified six studies that reported failure rates of SB crossing with a pressure guidewire (n = 648) and 11 studies that reported failure rates of SB crossing with a coronary guide-wire (n = 2601). Estimated pooled failure rate was 3·9% (95% CI: 1·5% to 9·6%) for inability to cross SB with pressure guidewire. Estimated pooled failure rate of SB crossing with coronary guidewire was 3·1% (95% CI: 1·5% to 6·2%). There was no significant difference between the failure rates in the two groups (P = 0·70).
  
  
  CONCLUSIONS
  The failure rates of SB crossing after MV stenting are low with both pressure and coronary guidewire procedures, with no significant difference between the two approaches.
authors.affiliation: Division of Cardiology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Sameer
authors.initials: S
authors.lastname: Ather
authors.affiliation: Department of Medicine, Mount Sinai St Luke's-Roosevelt Hospital Center, New York, NY, USA.
authors.forename: Chirag P
authors.initials: CP
authors.lastname: Bavishi
authors.affiliation: Division of Cardiology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Bhatia
authors.affiliation: Division of Cardiology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Navkaranbir S
authors.initials: NS
authors.lastname: Bajaj
authors.affiliation: Division of Cardiology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Massoud A
authors.initials: MA
authors.lastname: Leesar
mesh_terms: D023921:Coronary Stenosis / Q000601:surgery*; D003331:Coronary Vessels / Q000601:surgery*; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation* / Q000379:methods; D017211:Treatment Failure
keywords: Coronary bifurcation; fractional flow reserve; kissing balloon inflation; wires