title: BF3·OEt2-AgSCF3 Mediated Trifluoromethylthiolation/Cascade Cyclization of Propynols: Synthesis of 4-((Trifluoromethyl)thio)-2H-chromene and 4-((Trifluoromethyl)thio)-1,2-dihydroquinoline Derivatives.
abstract: A BF3·OEt2-AgSCF3 mediated direct trifluoromethylthiolation/cascade cyclization of propynols involving the SCF3 anion nucleophilic pathway is developed. This protocol also provides an opportunity to construct valuable trifluoromethylthio-substituted 2H-chromene and 1,2-dihydroquinoline systems with high efficiency under mild conditions. Additionally, the developed BF3·OEt2-AgSCF3 reaction system could be scaled up to gram quantities in a satisfactory yield without inert gas protection.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, People's Republic of China.
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Qiu
authors.affiliation: Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science Technology Normal University , Nanchang, People's Republic of China.
authors.forename: Xian-Rong
authors.initials: XR
authors.lastname: Song
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, People's Republic of China.
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, People's Republic of China.
authors.forename: An-Qi
authors.initials: AQ
authors.lastname: Wang
authors.affiliation: College of Science, Northwest A&F University , 3 Taicheng Road, Yangling, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, People's Republic of China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Han
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, People's Republic of China.
authors.forename: Heng-Rui
authors.initials: HR
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, People's Republic of China.
authors.forename: Dong-Po
authors.initials: DP
authors.lastname: Jin
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, People's Republic of China.
authors.forename: Ying-Xiu
authors.initials: YX
authors.lastname: Li
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, People's Republic of China.
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang