title: Non-cirrhotic portal fibrosis at a tertiary care centre in South India.
abstract: BACKGROUND
  Non-cirrhotic portal fibrosis (NCPF) is one of the important causes of upper gastrointestinal haemorrhage in patients in tropical countries. The aim of this study was to describe the clinical and laboratory profile of 68 patients with NCPF.
  
  
  METHODS
  NCPF is defined as liver disease with: (1) evidence of portal hypertension; (2) a liver biopsy showing no cirrhosis or a Tc-labelled sulphur colloid scan showing a pattern suggestive of NCPF; and (3) a patent splenoportal axis. The clinical, laboratory and demographic features of 68 patients with such criteria were studied and analysed.
  
  
  RESULTS
  NCPF was common in women (73.5%) in the fourth decade of life. The median duration of illness was 24 months (range, 1 month-28 years). Patients presented to hospital with the sensation of a mass in the abdomen (50%) or with haematemesis (26.5%). They had splenomegaly (95.6%) and thrombocytopenia (88.2%). The majority of patients had normal liver function tests. Abdominal ultrasonography showed increased periportal and peri gallbladder echoes (72%), spontaneous collaterals (41.2%) and ascites (19.1%). Liver biopsy revealed portal venous sclerosis (76.3%) and periportal fibrosis (55.3%). Tc-labelled sulphur colloid scan was suggestive of NCPF in the remaining 30 cases.
  
  
  CONCLUSIONS
  NCPF is common in South India. Transient ascites occurs due to decompensation of liver function after variceal bleeding and in long standing cases of NCPF. Our study used Tc-sulphur scan for diagnosing NCPF in patients where liver biopsy was contraindicated in view of severe thrombocytopenia; however, the diagnostic utility of Tc-sulphur nuclear scan to diagnose NCPF in patients with severe hypersplenism needs to be further evaluated in future studies.
authors.affiliation: Ex-Associate Professor, Associate Professor, Department of Medicine JIPMER, Puducherry, India mukta.wyawahare@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Mukta
authors.affiliation: Ex-Assistant Professor, Department of Gastroenterology JIPMER, Puducherry, India.
authors.forename: Lakshmi C
authors.initials: LC
authors.lastname: Panicker
authors.affiliation: Post graduate student, Department of Medicine JIPMER, Puducherry, India.
authors.forename: Kalaimani
authors.initials: K
authors.lastname: Sivamani
authors.affiliation: Ex-Assistant Professor, Department of Gastroenterology JIPMER, Puducherry, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Goel
authors.affiliation: Professor, Department of Pathology JIPMER, Puducherry, India.
authors.forename: Debdutta
authors.initials: D
authors.lastname: Basu
authors.affiliation: Associate Professor, Department of Nuclear Medicine JIPMER, Puducherry, India.
authors.forename: Halnayak
authors.initials: H
authors.lastname: Dhanapathi
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005355:Fibrosis / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D006971:Hypersplenism / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology; D006975:Hypertension, Portal / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011168:Portal System; D012307:Risk Factors; D062606:Tertiary Care Centers
keywords: Non-cirrhotic portal fibrosis (NCPF); portal hypertension; splenomegaly