title: Subgroup differences in 'brain-type' transferrin and α-synuclein in Parkinson's disease and multiple system atrophy.
abstract: Two transferrin (Tf) glycan-isoforms were previously found in cerebrospinal fluid (CSF); one appears to be derived from serum (Tf-2) and the other from choroid plexus, a CSF-producing tissue (Tf-1). To analyse metabolic differences associated with the two isoforms, their ratio (Tf-2/Tf-1) was defined as the Tf index. Here we report that Tf indices of patients with tauopathies including Alzheimer's disease (2.29 + 0.64) were similar to those of neurological controls (2.07 + 0.87) (P = 0.147). In contrast, Tf indices with Parkinson's disease (PD, 3.38 ± 1.87) and multiple system atrophy (MSA, 3.15 ± 1.72) were higher than those of the controls (2.07 ± 0.87), the P-values being < 0.001 and 0.024, respectively. Tf indices of PD and MSA did not appear to be normally distributed. Indeed, detrended normal Quantile-Quantile plot analysis revealed the presence of an independent subgroup showing higher Tf indices in PD and MSA. The subgroup of PD showed higher levels of CSF α-synuclein (38.3 ± 17.8 ng/ml) than the rest (25.3 ± 11.3 ng/ml, P = 0.012). These results suggest that PD (and MSA) includes two subgroups, which show different metabolism of CSF transferrin and α-synuclein.
authors.affiliation: Departments of Neurology;
authors.forename: Akioh
authors.initials: A
authors.lastname: Yoshihara
authors.affiliation: Bixochemistry;
authors.forename: Masahiko
authors.initials: M
authors.lastname: Fukatsu
authors.affiliation: Bixochemistry; Departments of Neurology;
authors.forename: Kyoka
authors.initials: K
authors.lastname: Hoshi
authors.affiliation: Bixochemistry;
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ito
authors.affiliation: Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima City, Japan;
authors.forename: Kenneth
authors.initials: K
authors.lastname: Nollet
authors.affiliation: Structural Glycobiology Team, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center, RIKEN Global Research Cluster, Wako, Saitama;
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yamaguchi
authors.affiliation: Department of Molecular Pathobiology of Brain Diseases (Department of Neurology), Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto;
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Ishii
authors.affiliation: Department of Molecular Pathobiology of Brain Diseases (Department of Neurology), Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto;
authors.forename: Takahiko
authors.initials: T
authors.lastname: Tokuda
authors.affiliation: Department of Neurosurgery, Juntendo University, Bunkyo-ku, Tokyo;
authors.forename: Masakazu
authors.initials: M
authors.lastname: Miyajima
authors.affiliation: Department of Neurosurgery, Juntendo University, Bunkyo-ku, Tokyo;
authors.forename: Hajime
authors.initials: H
authors.lastname: Arai
authors.affiliation: Graduate School of Medical Science, Major of Environmental Life Science, Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University;
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
authors.affiliation: Institute of Development, Aging and Cancer, Tohoku University;
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Furukawa
authors.affiliation: Institute of Development, Aging and Cancer, Tohoku University;
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
authors.affiliation: Department of Neurology, Tohoku University School of Medicine; and.
authors.forename: Akio
authors.initials: A
authors.lastname: Kikuchi
authors.affiliation: Sendai Nishitaga National Hospital, Sendai, Miyagi, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeda
authors.affiliation: Departments of Neurology;
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ugawa
authors.affiliation: Bixochemistry;
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D000544:Alzheimer Disease / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000097:blood / Q000134:cerebrospinal fluid; D020033:Protein Isoforms / Q000097:blood / Q000134:cerebrospinal fluid; D014168:Transferrin / Q000134:cerebrospinal fluid*; D051844:alpha-Synuclein / Q000097:blood / Q000134:cerebrospinal fluid
chemical_list: D020033:Protein Isoforms; D014168:Transferrin; D051844:alpha-Synuclein
keywords: Parkinson’s disease; cerebrospinal fluid; synucleinopathy; transferring; α-synuclein