title: Membrane dynamics in mammalian embryogenesis: Implication in signal regulation.
abstract: Eukaryotes have evolved an array of membrane compartments constituting secretory and endocytic pathways that allow the flow of materials. Both pathways perform important regulatory roles. The secretory pathway is essential for the production of extracellular, secreted signal molecules, but its function is not restricted to a mere route connecting intra- and extracellular compartments. Post-translational modifications also play an integral function in the secretory pathway and are implicated in developmental regulation. The endocytic pathway serves as a platform for relaying signals from the extracellular stimuli to intracellular mediators, and then ultimately inducing signal termination. Here, we discuss recent studies showing that dysfunction in membrane dynamics causes patterning defects in embryogenesis and tissue morphogenesis in mammals.
authors.affiliation: Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka, 567-0047, Japan.
authors.forename: Yoh
authors.initials: Y
authors.lastname: Wada
authors.affiliation: Department of Biochemistry, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kohdo, Kyotanabe, Kyoto, 610-0395, Japan.
authors.forename: Ge-Hong
authors.initials: GH
authors.lastname: Sun-Wada
authors.affiliation: Department of Biochemistry, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kohdo, Kyotanabe, Kyoto, 610-0395, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kawamura
authors.affiliation: Department of Biochemistry, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kohdo, Kyotanabe, Kyoto, 610-0395, Japan.
authors.forename: Jyunichiro
authors.initials: J
authors.lastname: Yasukawa
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian; D047108:Embryonic Development / Q000502:physiology*; D006801:Humans; D008566:Membranes / Q000502:physiology*; D009024:Morphogenesis / Q000502:physiology; D015388:Organelles / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
keywords: embryogenesis; endocytosis; secretory pathway; signal transduction