title: [Preparation and stability of β-carotene loaded using mesoporous silica nanoparticles as carriers system].
abstract: 1,3,5-Trimethylbenzene (1,3,5-TMB) was used as the pore-enlarging modifier to expand the pore size of MCM-41 (mobil company of matter) mesoporous silica nanoparticles. The solvent impregnation method was adopted to assemble non-water-soluble β-carotene into the pore channel of MCM-41. The MCM-41 and drug assemblies were characterized by TEM, FT-IR, elemental analysis and N2 adsorption-desorption. The results showed that MCM-41 has good sphericity and regular pore structure. The research also investigated the optimal loading time, the drug loading and the vitro stability of the β-carotene. As a drug carrier, the modified MCM-41 showing a shorter drug loading time, the drug loading as high as 85.58% and the stability of β-carotene in drug assemblies has improved. The study of this new formulation provides a new way for β-carotene application.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Zhi-hui
authors.initials: ZH
authors.lastname: Ren
authors.forename: Hai-yuan
authors.initials: HY
authors.lastname: Wang
authors.forename: Xing-hua
authors.initials: XH
authors.lastname: Jin
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004355:Drug Stability; D053758:Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D019207:beta Carotene / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; C509968:MCM-41; D019207:beta Carotene; D012822:Silicon Dioxide