title: Fermented Goat's Milk Consumption Improves Duodenal Expression of Iron Homeostasis Genes during Anemia Recovery.
abstract: Despite the crucial roles of duodenal cytochrome b (Dcytb), divalent metal transporter 1 (DMT1), ferritin light chain (Ftl1), ferroportin 1 (FPN1), transferrin receptor 1 (TfR1), and hepcidin antimicrobial peptide (Hamp) in Fe metabolism, no studies have investigated the modulations of these genes during Fe repletion with fermented milks. Analysis included Fe status markers and gene and protein expression in enterocytes of control and anemic animals fed fermented milks. Fermented goat's milk up-regulated enterocyte Dcytb, DMT1, FPN1, and Ftl1 and down-regulated TfR1 and Hamp gene expression in control and anemic animals. Anemia decreased Dcytb, DMT1, and Ftl1 in animals fed fermented cow's milk and up-regulated TfR1 and Hamp expression. Fe overload down-regulated Dcytb and TfR1 in animals fed fermented cow's milk and up-regulated DMT1 and FPN1 gene expression. Fermented goat's milk increased expression of duodenal Dcytb, DMT1, and FPN1 and decreased Hamp and TfR1, improving Fe metabolism during anemia recovery.
authors.affiliation: Department of Physiology, University of Granada , Granada, Spain.|Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada , Granada, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Moreno-Fernandez
authors.affiliation: Department of Physiology, University of Granada , Granada, Spain.|Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada , Granada, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Diaz-Castro
authors.affiliation: Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada , Granada, Spain.|Department of Biochemistry and Molecular Biology II, University of Granada , Granada, Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: Pulido-Moran
authors.affiliation: Department of Physiology, University of Granada , Granada, Spain.|Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada , Granada, Spain.
authors.forename: Maria J M
authors.initials: MJ
authors.lastname: Alferez
authors.affiliation: School of Food Science and Nutrition, University of Leeds , Leeds, United Kingdom.
authors.forename: Christine
authors.initials: C
authors.lastname: Boesch
authors.affiliation: Department of Physiology, University of Granada , Granada, Spain.|Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada , Granada, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Sanchez-Alcover
authors.affiliation: Department of Physiology, University of Granada , Granada, Spain.|Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada , Granada, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: López-Aliaga
mesh_terms: D000740:Anemia / Q000378:metabolism*; D000818:Animals; D015703:Antigens, CD; D027682:Cation Transport Proteins / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism*; D004386:Duodenum / Q000378:metabolism*; D020895:Enterocytes / Q000378:metabolism; D005260:Female; D005285:Fermentation; D006041:Goats; D006706:Homeostasis / Q000187:drug effects; D007501:Iron / Q000378:metabolism*; D008892:Milk / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D011990:Receptors, Transferrin / Q000378:metabolism; D000099236:Solute Carrier Family 11, Member 2
chemical_list: D015703:Antigens, CD; D027682:Cation Transport Proteins; D003573:Cytochrome b Group; D007501:Iron; D010088:Oxidoreductases; D011990:Receptors, Transferrin; D000099236:Solute Carrier Family 11, Member 2; C068126:CD71 antigen; C545564:Tfrc protein, rat
keywords: Fe repletion; anemia; fermented cow’s and goat’s milk; gene expression; iron metabolism