title: [Activation of caspases in lymphocytes of patients with depression and anxiety].
abstract: The processes in the nervous and immune systems are closely interrelated. In particular, increased apoptosis was reported in lymphocytes of patients with depression. The aim of this study was to assess activities of proteases associated with cell death in lymphocytes of patient with personality disorders accompanied by depression and anxiety. In patients with personality disorders associated with organic brain dysfunction caspase activities were reduced in patients with depression and increased in patients with anxiety. The results may be useful for elucidation of pathogenetic mechanisms of personality disorders and in search of new biomarkers of these diseases.
authors.affiliation: Lomonosov Moscow State University, Moscow, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Gerasimovich
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia; Scientific Clinical Center of Psychoneurology, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Yakovlev
authors.affiliation: Scientific Clinical Center of Psychoneurology, Moscow, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Druzhkova
authors.affiliation: Scientific Clinical Center of Psychoneurology, Moscow, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Grishkina
authors.affiliation: Scientific Clinical Center of Psychoneurology, Moscow, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Guekht
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia; Scientific Clinical Center of Psychoneurology, Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Gulyaeva
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D001883:Borderline Personality Disorder / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D020169:Caspases / Q000276:immunology / Q000378:metabolism; D003863:Depression / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D020169:Caspases
keywords: anxiety; apoptosis; caspases; depression; lymphocytes; plasma peptides