title: Chitosan: An Adjuvant with an Unanticipated STING.
abstract: Adjuvants promote adaptive immunity through the triggering of innate signals that are largely poorly understood. In this issue of Immunity, Lavelle and colleagues describe an unexpected role for the DNA sensing cGAS-STING pathway in the mechanism of action of the Th1 cell-promoting polysaccharide adjuvant chitosan.
authors.affiliation: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Riteau
authors.affiliation: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: asher@niaid.nih.gov.
authors.forename: Alan
authors.initials: A
authors.lastname: Sher
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D048271:Chitosan / Q000008:administration & dosage*; D003713:Dendritic Cells / Q000502:physiology*; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D009713:Nucleotidyltransferases / Q000378:metabolism*; D018417:Th1 Cells / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D008565:Membrane Proteins; D048271:Chitosan; D009713:Nucleotidyltransferases