title: Hollow-Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds.
abstract: Knowledge of pharmacokinetic/pharmacodynamic (PK/PD) relationships can enhance the speed and economy of drug development by enabling informed and rational decisions at every step, from lead selection to clinical dosing. For anti-infective agents in particular, dynamic in vitro hollow-fiber cartridge experiments permit exquisite control of kinetic parameters and the study of their consequent impact on pharmacodynamic efficacy. Such information is of great interest for the cost-restricted but much-needed development of new antimalarial drugs, especially since the major human pathogen Plasmodium falciparum can be cultivated in vitro but is not readily available in animal models. This protocol describes the materials and procedures for determining the PK/PD relationships of antimalarial compounds.
authors.affiliation: Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, and The Johns Hopkins Malaria Research Institute, The Johns Hopkins University, Baltimore, Maryland.
authors.forename: Emily
authors.initials: E
authors.lastname: Caton
authors.affiliation: Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, and The Johns Hopkins Malaria Research Institute, The Johns Hopkins University, Baltimore, Maryland.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Nenortas
authors.affiliation: Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, and The Johns Hopkins Malaria Research Institute, The Johns Hopkins University, Baltimore, Maryland.
authors.forename: Rahul P
authors.initials: RP
authors.lastname: Bakshi
authors.affiliation: Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, and The Johns Hopkins Malaria Research Institute, The Johns Hopkins University, Baltimore, Maryland.
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Shapiro
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000493:pharmacokinetics* / Q000494:pharmacology*; D019540:Area Under Curve; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004867:Equipment Design; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials
keywords: Plasmodium falciparum; drug development; dynamic PK/PD; hollow-fiber cartridge system; malaria; pharmacodynamics; pharmacokinetics