title: Oxytocin (OT) and arginine-vasopressin (AVP) act on OT receptors and not AVP V1a receptors to enhance social recognition in adult Syrian hamsters (Mesocricetus auratus).
abstract: Social recognition is a fundamental requirement for all forms of social relationships. A majority of studies investigating the neural mechanisms underlying social recognition in rodents have investigated relatively neutral social stimuli such as juveniles or ovariectomized females over short time intervals (e.g., 2h). The present study developed a new testing model to study social recognition among adult males using a potent social stimulus. Flank gland odors are used extensively in social communication in Syrian hamsters and convey important information such as dominance status. We found that the recognition of flank gland odors after a 3min exposure lasted for at least 24h, substantially longer than the recognition of other social cues in rats and mice. Intracerebroventricular injections of OT and AVP prolonged the recognition of flank gland odor for up to 48h. Selective OTR but not V1aR agonists, mimicked these enhancing effects of OT and AVP. Similarly, selective OTR but not V1aR antagonists blocked recognition of the odors after 20min. In contrast, the recognition of non-social stimuli was not blocked by either the OTR or the V1aR antagonists. Our findings suggest both OT and AVP enhance social recognition via acting on OTRs and not V1aRs and that the recognition enhancing effects of OT and AVP are limited to social stimuli.
authors.affiliation: Neuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Song
authors.affiliation: Neuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.
authors.forename: Tony E
authors.initials: TE
authors.lastname: Larkin
authors.affiliation: Neuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.
authors.forename: Maureen O'
authors.initials: MO
authors.lastname: Malley
authors.affiliation: Neuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA. Electronic address: biohea@gsu.edu.
authors.forename: H Elliott
authors.initials: HE
authors.lastname: Albers
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology* / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects*; D006224:Cricetinae; D005260:Female; D008297:Male; D008647:Mesocricetus; D010121:Oxytocin / Q000494:pharmacology* / Q000502:physiology; D018045:Receptors, Oxytocin / Q000819:agonists / Q000378:metabolism*; D017483:Receptors, Vasopressin / Q000819:agonists / Q000378:metabolism; D021641:Recognition, Psychology / Q000187:drug effects*; D012919:Social Behavior
chemical_list: D018045:Receptors, Oxytocin; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; D010121:Oxytocin
keywords: Chemosensory, olfaction; Flank marking; Memory; Neurohypophyseal hormones; Neuropeptides; Nonapeptides; Odor recognition; Social behavior; Social communication