title: Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients.
abstract: BACKGROUND
  Type 2 diabetes mellitus (T2DM) has traditionally been considered to affect mainly the elderly; however, the age at diagnosis has gradually reduced in recent years. Although the incidence of young-onset T2DM is increasing, it is still not fully clear the onset characteristics and risk factors of early-onset T2DM. The aim of this study was to describe the initiating characteristics of early-onset T2DM in Chinese patients and evaluate the risk factors for diabetes mellitus.
  
  
  METHODS
  This cross-sectional controlled study was performed using a questionnaire survey method in outpatients of multiple centers in China. A total of 1545 patients with T2DM with an age at onset of <40 years were included, and the control group consisted of subjects aged <40 years with normal blood glucose level.
  
  
  RESULTS
  In patients with young-onset T2DM, the mean age and initial hemoglobin 1Ac at diagnosis were 32.96 ± 5.40 years and 9.59 ± 2.71%, respectively. Most of the patients were obese, followed irregular diet pattern and sedentary lifestyle, had life or work pressure, and had a family history of diabetes mellitus. Compared with subjects with normal blood glucose level, logistic regression analysis showed that waist-to-hip ratio (odds ratio [OR] 446.99, 95% confidence interval [CI] 42.37-4714.87), family history of diabetes mellitus (OR 23.46, CI 14.47-38.03), dyslipidemia (OR 2.65, CI 1.54-4.56), diastolic blood pressure (OR 1.02, CI 1.00-1.04), and body mass index (OR 0.95, CI 0.92-0.99) are independent factors for early-onset T2DM.
  
  
  CONCLUSIONS
  We observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM. It is, therefore, necessary to apply early lifestyle intervention in young people with risk of diabetes mellitus.
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Xie
authors.forename: Kang
authors.initials: K
authors.lastname: Chen
authors.forename: Gang-Yi
authors.initials: GY
authors.lastname: Yang
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Xing
authors.forename: Jia-Jun
authors.initials: JJ
authors.lastname: Zhao
authors.forename: Tian-Pei
authors.initials: TP
authors.lastname: Hong
authors.forename: Zhong-Yan
authors.initials: ZY
authors.lastname: Shan
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
authors.forename: Xu-Lei
authors.initials: XL
authors.lastname: Tang
authors.forename: Ling
authors.initials: L
authors.lastname: Qi
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.forename: Shuang-Shuang
authors.initials: SS
authors.lastname: Wang
authors.forename: Xue
authors.initials: X
authors.lastname: Liang
authors.forename: Ya-Qi
authors.initials: YQ
authors.lastname: Yin
authors.affiliation: Department of Endocrinology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Mu
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D012307:Risk Factors; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human