title: Development of an antioxidant biomaterial by promoting the deglycosylation of rutin to isoquercetin and quercetin.
abstract: Quercetin-3-O-rutinoside (rutin), quercetin-3-O-glucoside (isoquercetin) and quercetin have shown antioxidant, cytoprotective, vasoprotective, antiproliferative and antiinflammatory properties. The aim of this work was to determine the conversion of rutin to isoquercetin and quercetin during the production of poly(l-lactic acid) films with potential to deliver these flavonoids toward tissues, pharmaceuticals or food matrices. Three poly(l-lactic acid) formulations with 17.7, 39.6 and 39.1mg/g of rutin were prepared by the extrusion process. Processing temperatures (130-165°C) promoted the deglycosylation of rutin to produce isoquercetin and subsequently quercetin, identified by high performance liquid chromatography coupled to mass spectrometry. The effect of the process on the antioxidant activity of the films was determined by measuring the capacity to scavenge 2,2 diphenyl-1-picrylhydrazyl radicals. The material with the highest proportion of quercetin showed the highest antioxidant activity which could be used to produce delivering devices of the flavonoids to tissues, pharmaceuticals or food matrices.
authors.affiliation: Universidad Autónoma de Sinaloa, Gral. Ángel Flores s/n, Apdo. Postal 80000, Culiacán, Sinaloa, Mexico.
authors.forename: Johana M
authors.initials: JM
authors.lastname: Cruz-Zúñiga
authors.affiliation: Centro de Investigación en Alimentación y Desarrollo, A.C., CTAOV, Apdo. Postal 1735, Hermosillo, Sonora 83304, Mexico. Electronic address: hsoto@ciad.mx.
authors.forename: Herlinda
authors.initials: H
authors.lastname: Soto-Valdez
authors.affiliation: Centro de Investigación en Alimentación y Desarrollo, A.C., CTAOV, Apdo. Postal 1735, Hermosillo, Sonora 83304, Mexico.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Peralta
authors.affiliation: Centro de Investigación en Alimentación y Desarrollo, A.C., CTAOV, Apdo. Postal 1735, Hermosillo, Sonora 83304, Mexico.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Mendoza-Wilson
authors.affiliation: Centro de Investigación en Alimentación y Desarrollo, A.C., CTAOV, Apdo. Postal 1735, Hermosillo, Sonora 83304, Mexico.
authors.forename: M Refugio
authors.initials: MR
authors.lastname: Robles-Burgueño
authors.affiliation: School of Packaging, Michigan State University, East Lansing, MI 48824-1223, United States.
authors.forename: Rafael
authors.initials: R
authors.lastname: Auras
authors.affiliation: Universidad de Sonora, Blvd. Luis Encinas y Rosales s/n, Apdo. Postal 1658, Hermosillo, Sonora, 83000, Mexico.
authors.forename: Nohemí
authors.initials: N
authors.lastname: Gámez-Meza
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006031:Glycosylation; D013058:Mass Spectrometry; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry*; D012431:Rutin / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001672:Biocompatible Materials; C016527:isoquercitrin; D012431:Rutin; D011794:Quercetin
keywords: Antioxidant; Deglycosylation; Isoquercetin; Poly(l-lactic acid); Quercetin; Rutin