title: The Effect of Montelukast on Liver Damage in an Experimental Obstructive Jaundice Model.
abstract: BACKGROUND
  Montelukast is a cysteinyl-leukotriene type 1 (CysLT1) selective receptor antagonist. In recent years, investigations have shown that montelukast possesses secondary anti-inflammatory activities and also antioxidant effects. For this reason, we aimed to determine the possible effects of montelukast on liver damage in experimental obstructive jaundice.
  
  
  METHODS
  30 Wistar-Albino male rats were randomized and divided into three groups of 10 animals each: group I, sham-operated; group II, ligation and division of the common bile duct (BDL) followed by daily intraperitoneal injection of 1 ml of saline; group III, BDL followed by daily intraperitoneal injection of 10 mg/kg montelukast dissolved in saline. The animals were killed on postoperative day 7 by high-dose diethyl ether inhalation. Blood and liver samples were taken for examination.
  
  
  RESULTS
  In this study, liver malondialdehyde (MDA) (p = 0.001), myeloperoxidase (p = 0.003), and total sulfhydryl (SH) (p = 0.009) were found to be significantly different between the BDL + montelukast and the BDL groups. Plasma total SH (p = 0.002) and MDA (p = 0.027) values were also statistically different between these groups. Statistical analyses of histological activity index scores showed that the histopathological damage in the BDL + montelukast group was significantly less than the damage in the control group (p < 0.05 for all pathological parameters).
  
  
  CONCLUSIONS
  According to the results of this study, montelukast showed a significant hepatoprotective effect in this experimental obstructive jaundice model, which might be due to its antioxidant and anti-inflammatory activities.
authors.affiliation: Department of General Surgery, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Kuru
authors.affiliation: Department of General Surgery, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Kismet
authors.affiliation: Department of General Surgery, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Aziz M
authors.initials: AM
authors.lastname: Barlas
authors.affiliation: Department of General Surgery, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Tuncal
authors.affiliation: Department of Pathology, Aksaray State Hospital, Aksaray, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Celepli
authors.affiliation: Department of Biochemistry, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Surer
authors.affiliation: Department of Biochemistry, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Elmas
authors.initials: E
authors.lastname: Ogus
authors.affiliation: Department of General Surgery, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Ertas
keywords: Hepatobiliary diseases; Histopathology; Montelukast; Obstructive jaundice; Oxidative stress