title: Formation and Biopharmaceutical Characterization of Electrospun PVP Mats with Propolis and Silver Nanoparticles for Fast Releasing Wound Dressing.
abstract: Antibacterial, antiviral, antifungal, antioxidant, anti-inflammatory, and anticancer activities of propolis and its ability to stimulate the immune system and promote wound healing make it a proper component for wound dressing materials. Silver nanoparticles are recognized to demonstrate strong antiseptic and antimicrobial activity; thus, it also could be considered in the development of products for wound healing. Combining propolis and silver nanoparticles can result in improved characteristics of products designed for wound healing and care. The aim of this study was to formulate electrospun fast dissolving mats for wound dressing containing propolis ethanolic extract and silver nanoparticles. Produced electrospun nano/microfiber mats were evaluated studying their structure, dissolution rate, release of propolis phenolic compounds and silver nanoparticles, and antimicrobial activity. Biopharmaceutical characterization of electrospun mats demonstrated fast release of propolis phenolic compounds and silver nanoparticles. Evaluation of antimicrobial activity on Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Bacillus subtilis, Bacillus cereus, and Candida albicans strains confirmed the ability of electrospun mats to inhibit the growth of the tested microorganisms.
authors.affiliation: Department of Materials Engineering, Faculty of Mechanical Engineering and Design, Kaunas University of Technology, Studentų 56, LT-51424 Kaunas, Lithuania.
authors.forename: Erika
authors.initials: E
authors.lastname: Adomavičiūtė
authors.affiliation: Department of Materials Engineering, Faculty of Mechanical Engineering and Design, Kaunas University of Technology, Studentų 56, LT-51424 Kaunas, Lithuania.
authors.forename: Sigitas
authors.initials: S
authors.lastname: Stanys
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, Sukilėlių pr. 13, LT-50161 Kaunas, Lithuania.
authors.forename: Modestas
authors.initials: M
authors.lastname: Žilius
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, Sukilėlių pr. 13, LT-50161 Kaunas, Lithuania.
authors.forename: Vaida
authors.initials: V
authors.lastname: Juškaitė
authors.affiliation: Institute of Microbiology and Virology, Lithuanian University of Health Sciences, Eivenių g. 4, LT-50161 Kaunas, Lithuania.
authors.forename: Alvydas
authors.initials: A
authors.lastname: Pavilonis
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, Sukilėlių pr. 13, LT-50161 Kaunas, Lithuania.
authors.forename: Vitalis
authors.initials: V
authors.lastname: Briedis
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use; D001458:Bandages; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D011145:Polyvinyls / Q000737:chemistry / Q000627:therapeutic use; D011429:Propolis / Q000737:chemistry / Q000627:therapeutic use*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011759:Pyrrolidines / Q000737:chemistry / Q000627:therapeutic use; D012834:Silver / Q000737:chemistry / Q000627:therapeutic use; D013211:Staphylococcus aureus / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D011145:Polyvinyls; D011759:Pyrrolidines; C505150:poly(N-vinylpyrrolidine); D012834:Silver; D011429:Propolis