title: False-negative Frozen Section of Sentinel Lymph Node Biopsy in a Chinese Population with Breast Cancer.
abstract: OBJECTIVE
  This study aimed to investigate the accuracy of frozen section (FS) in diagnosis of sentinel lymph node metastasis and to analyze the predictive factors for false-negativity.
  
  
  METHODS
  Patients with breast cancer and clinically negative axillary were recruited for sentinel lymph node biopsy (SLNB). All nodes were examined by intraoperative FS and underwent further paraffin sectioning.
  
  
  RESULTS
  A total of 1,272 patients underwent SLNB over an 8-year period, and 53 patients had false-negative FS. Univariate and multivariate analysis revealed that younger age, stellate mammographic pattern, and ER-positive status were statistically different when compared to the 53 members of the cohort who were truly negative on SLNB (control group). Eight patients were lost to clinical follow-up; the recurrence-free survival rate of the remaining 49 patients with false-negative SLNB did not differ from that of the 49-patient cohort (control group) (p=0.072), while these patients did experience poorer overall survival (p=0.035).
  
  
  CONCLUSIONS
  Younger age, stellate mammographic pattern and ER-positive status were independent predictors for false-negative FS on biopsy.
authors.affiliation: Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong, P.R. China.
authors.forename: Guangdong
authors.initials: G
authors.lastname: Qiao
authors.affiliation: Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong, P.R. China.
authors.forename: Yizi
authors.initials: Y
authors.lastname: Cong
authors.affiliation: Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong, P.R. China.
authors.forename: Haidong
authors.initials: H
authors.lastname: Zou
authors.affiliation: Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong, P.R. China.
authors.forename: Xingmiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong, P.R. China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong, P.R. China.
authors.forename: Yalun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong, P.R. China ytzhushiguang@medmail.com.cn.
authors.forename: Shiguang
authors.initials: S
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla / Q000473:pathology* / Q000502:physiology*; D001943:Breast Neoplasms / Q000473:pathology*; D005188:False Negative Reactions; D005260:Female; D005629:Frozen Sections / Q000379:methods; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy / Q000379:methods
keywords: Breast neoplasms; false-negative reaction; frozen section; predictive value of tests; sentinel lymph node biopsy