title: Cobalt-Catalyzed Asymmetric Hydrogenation of 1,1-Diarylethenes.
abstract: Highly enantioselective cobalt-catalyzed hydrogenation of 1,1-diarylethenes was developed by using bench-stable chiral oxazoline iminopyridine-cobalt complexes as precatalysts. A unique o-chloride effect was observed to achieve high enantioselectivity. Easy removal as well as further transformations of the chloro group make this protocol a potentially useful alternative to synthesize various chiral 1,1-diarylethanes. This process can be successfully performed under 1 atm of hydrogen at room temperature on gram scale.
authors.affiliation: Department of Chemistry, Zhejiang University , 866 Yuhangtang Road, Hangzhou 310058, China.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Zhejiang University , 866 Yuhangtang Road, Hangzhou 310058, China.
authors.forename: Chenhui
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Zhejiang University , 866 Yuhangtang Road, Hangzhou 310058, China.
authors.forename: Chonglei
authors.initials: C
authors.lastname: Ji
authors.affiliation: Department of Chemistry, Zhejiang University , 866 Yuhangtang Road, Hangzhou 310058, China.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Lu