title: The utility of biomarker risk prediction score in patients with chronic heart failure.
abstract: BACKGROUND
  Chronic heart failure (CHF) has been remained a leading cause of cardiovascular morbidity and mortaluty. The risk stratification of CHF individuals based on clinical criteria and biomarkers' models may improve medical care and probably increase efficacy of treatment strategy. However, various predictive models approved for CHF patients appear to be distinguished in their prognostications. The study aim was to evaluate whether biomarker risk prediction score is powerful tool for risk assessment of three-year fatal and non-fatal cardiovascular events in CHF patients.
  
  
  METHODS
  It was studied prospectively the incidence of fatal and non-fatal cardiovascular events in a cohort of 388 patients with ischemic-induced CHF within 3 years. Circulating biomarkers were collected at baseline of the study.
  
  
  RESULTS
  Independent predictors of clinical outcomes in patients with CHF were NT-pro-BNP, galectin-3, hs-CRP, osteoprotegerin, CD31(+)/annexin V(+) endothelail-derived microparticles (EMPs) and CD31(+)/annexin V(+) EMPs to CD14(+)CD309(+) monuclear progenitor cells (MPCs) ratio. Index of cardiovascular risk was calculated by mathematical summation of all ranks of independent predictors, which occurred in the patients included in the study. Kaplan-Meier analysis showed that patients with CHF and the magnitude of the risk of less than 4 units have an advantage in survival when compared with patients for whom obtained higher values of cardiovascular risk score ranks.
  
  
  CONCLUSIONS
  Biomarker risk score for cumulative cardiovascular events, constructed by measurement of circulating NT-pro-BNP, galectin-3, hs-CRP, osteoprotegerin, CD31+/annexin V+ EMPs and CD31(+)/annexin V(+) EMPs to CD14(+)CD309(+) MPCs ratio, allowing reliably predict the probability survival of patients with CHF.
authors.affiliation: Internal Medicine Department, State Medical University, 26, Mayakovsky av, Zaporozhye,, UA-69035 Ukraine.
authors.forename: Alexander E
authors.identifier: 0000-0002-0446-3999
authors.initials: AE
authors.lastname: Berezin
authors.affiliation: Clinical Pharmacology Department, State Medical University, Zaporozhye, Ukraine.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Kremzer
authors.affiliation: Pathology Department, State Medical University, Zaporozhye, Ukraine.
authors.forename: Yulia V
authors.initials: YV
authors.lastname: Martovitskaya
authors.affiliation: Private Medical Center "Vita-center", Zaporozhye, Ukraine.
authors.forename: Tatyana A
authors.initials: TA
authors.lastname: Berezina
authors.affiliation: Clinical Pharmacology Department, State Medical University, Zaporozhye, Ukraine.
authors.forename: Tatyana A
authors.initials: TA
authors.lastname: Samura
keywords: Biomarkers; Cardiovascular outcomes; Chronic heart failure; Predictive value