title: In vivo imaging of retinal hemodynamics with OCT angiography and Doppler OCT.
abstract: Retinal hemodynamics is important for early diagnosis and precise monitoring in retinal vascular diseases. We propose a novel method for measuring absolute retinal blood flow in vivo using the combined techniques of optical coherence tomography (OCT) angiography and Doppler OCT. Doppler values can be corrected by Doppler angles extracted from OCT angiography images. A three-dimensional (3D) segmentation algorithm based on dynamic programming was developed to extract the 3D boundaries of optic disc vessels, and Doppler angles were calculated from 3D vessel geometry. The accuracy of blood flow from the Doppler OCT was validated using a flow phantom. The feasibility of the method was tested on a subject in vivo. The pulsatile retinal blood flow and the parameters for retinal hemodynamics were successfully obtained.
authors.affiliation: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China; Co-first authors: they have contributed equally to the project.
authors.forename: Shenghai
authors.initials: S
authors.lastname: Huang
authors.affiliation: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China; Co-first authors: they have contributed equally to the project.
authors.forename: Meixiao
authors.initials: M
authors.lastname: Shen
authors.affiliation: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Dexi
authors.initials: D
authors.lastname: Zhu
authors.affiliation: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.affiliation: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Ce
authors.initials: C
authors.lastname: Shi
authors.affiliation: University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California, USA.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
authors.affiliation: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Lu
keywords: (100.2960) Image analysis; (100.6890) Three-dimensional image processing; (170.4460) Ophthalmic optics and devices; (170.4500) Optical coherence tomography