title: Combination therapy with daclatasvir and asunaprevir for dialysis patients infected with hepatitis C virus.
abstract: The standard antiviral therapy for dialysis patients infected with hepatitis C virus (HCV) is (pegylated) interferon monotherapy, but its efficacy is insufficient. Oral direct-acting antiviral agents (DAAs) have recently been developed for chronic hepatitis C patients. However, some DAAs have contraindications for chronic renal failure (CRF). Daclatasvir and asunaprevir are metabolized largely in the liver and are not contraindicated in CRF. Combination therapy with daclatasvir and asunaprevir was used for 4 dialysis patients infected with genotype 1b HCV. One patient had viral breakthrough, and the 3 others had sustained virological response 12. One patient was admitted for heart failure and percutaneous coronary intervention due to concomitant ischemic disease. Heart failure was unlikely to be caused by the combination therapy, as it was probably due to water overload. The patient continued to receive the combination therapy after the remission of the heart failure. The combination therapy was well tolerated in the other patients.
authors.affiliation: Ken Sato, Yuichi Yamazaki, Tatsuya Ohyama, Takeshi Kobayashi, Norio Horiguchi, Satoru Kakizaki, Masanobu Yamada, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.affiliation: Ken Sato, Yuichi Yamazaki, Tatsuya Ohyama, Takeshi Kobayashi, Norio Horiguchi, Satoru Kakizaki, Masanobu Yamada, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamazaki
authors.affiliation: Ken Sato, Yuichi Yamazaki, Tatsuya Ohyama, Takeshi Kobayashi, Norio Horiguchi, Satoru Kakizaki, Masanobu Yamada, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ohyama
authors.affiliation: Ken Sato, Yuichi Yamazaki, Tatsuya Ohyama, Takeshi Kobayashi, Norio Horiguchi, Satoru Kakizaki, Masanobu Yamada, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: Ken Sato, Yuichi Yamazaki, Tatsuya Ohyama, Takeshi Kobayashi, Norio Horiguchi, Satoru Kakizaki, Masanobu Yamada, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Horiguchi
authors.affiliation: Ken Sato, Yuichi Yamazaki, Tatsuya Ohyama, Takeshi Kobayashi, Norio Horiguchi, Satoru Kakizaki, Masanobu Yamada, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kakizaki
authors.affiliation: Ken Sato, Yuichi Yamazaki, Tatsuya Ohyama, Takeshi Kobayashi, Norio Horiguchi, Satoru Kakizaki, Masanobu Yamada, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Kusano
authors.affiliation: Ken Sato, Yuichi Yamazaki, Tatsuya Ohyama, Takeshi Kobayashi, Norio Horiguchi, Satoru Kakizaki, Masanobu Yamada, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Yamada
keywords: Asunaprevir; Daclatasvir; Dialysis; Hepatitis C; Oral drug