title: Changes in Doppler parameters of portal pressure after interventional management of hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) has many options for management; some of them are complicated by development of portal hypertension (PHT). Doppler ultrasound is an effective method to diagnose and monitor PHT changes after HCC ablation procedures. The aim of this study is to investigate changes in portal pressure hemodynamics of HCC patients following treatment with different interventional strategies: radiofrequency ablation (RFA), microwave ablation (MWA), and transarterial chemoembolization (TACE). A total of 60 patients with HCC were divided into three main groups, and each group received a different type of therapy (RFA, MWA, and TACE). Full medical record and basic investigations were performed including Doppler ultrasound and upper GIT endoscopy for evaluation of PHT parameters, and then repeated after three months of ablation. RFA is associated with the increased splenic artery resistive index, while MWA has no significant impact on PHT indices. TACE has led to a marked increase in liver vascular index with significant decrease in hepatic artery resistive index and PHI after treatment. No significant changes in esophageal varices were observed by upper GIT endoscopy following all ablation methods. RFA is quite safe but associated with degree of PHT. On the contrary, TACE is associated with improved PHT parameters. MWA has no significant association to development of PHT following the technique. Doppler ultrasound could be used as a reliable and effective method of evaluation of PHT post ablation for HCC.
authors.affiliation: Tropical Medicine Department, Mansoura Faculty of Medicine, Mansoura University Hospital, Mansoura, 35516, Egypt.
authors.forename: Walid
authors.initials: W
authors.lastname: El Sherbiny
authors.affiliation: Diagnostic Radiology Department, Mansoura University Children Hospital, Mansoura, Egypt.
authors.forename: Ashraf
authors.initials: A
authors.lastname: AbdelRahman
authors.affiliation: Tropical Medicine Department, Mansoura Faculty of Medicine, Mansoura University Hospital, Mansoura, 35516, Egypt.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Diasty
authors.affiliation: Tropical Medicine Department, Mansoura Faculty of Medicine, Mansoura University Hospital, Mansoura, 35516, Egypt. shakershaltout2@yahoo.com.
authors.forename: Shaker Wagih
authors.identifier: 0000-0002-4304-3276
authors.initials: SW
authors.lastname: Shaltout
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis* / Q000503:physiopathology; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D017082:Portal Pressure / Q000502:physiology*; D011446:Prospective Studies; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler / Q000379:methods*
keywords: Ablation; Doppler ultrasound; Hepatocellular carcinoma; MWA; Portal hypertension; RFA; TACE