title: Vanadium Complex Derived from N'-(3-Bromo-5-chloro-2-hydroxybenzylidene) -3-methylbenzohydrazide: Synthesis, Crystal Structure and Biological Activity.
abstract: Reaction of VO(acac)(2) with N'-(3-bromo-5-chloro-2-hydroxybenzylidene)-3-methylbenzohydrazide (H(2)L) in methanol afforded a new mononuclear vanadium(V) complex, [VOL(OMe)(MeOH)]. Structure of the complex has been characterized by physico-chemical methods and single-crystal X-ray diffraction. The complex crystallizes as the monoclinic space group P2(1)/c, with unit cell dimensions a = 13.1345(10) Å, b = 18.6279(14) Å, c = 7.8983(8) Å, β = 90.248(2)º, V = 1932.4(3) Å(3), Z = 4, R(1) = 0.0963, wR(2) = 0.2213, S = 1.113. X-ray analysis indicated that the V atom in the complex is in octahedral coordination. The insulin-like activity of the complex was studied.
authors.forename: Zhen-Quan
authors.initials: ZQ
authors.lastname: Han
authors.forename: Shuang
authors.initials: S
authors.lastname: Han
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006835:Hydrazones / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014639:Vanadium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D006835:Hydrazones; D007004:Hypoglycemic Agents; D014639:Vanadium