title: Multimodal Outcome at 7 Years of Age after Neonatal Arterial Ischemic Stroke.
abstract: To evaluate the epileptic, academic, and developmental status at age 7 years in a large population of term-born children who sustained neonatal arterial ischemic stroke (NAIS), and to assess the co-occurrence of these outcomes.
  
  
  
  A cohort study including 100 term newborns with NAIS was designed. Two infants died during the neonatal period, 13 families were lost to follow-up, and 5 families declined to participate in this evaluation. Thus, 80 families completed the 7-year clinical assessment. Epileptic status, schooling, motor abilities, global intellectual functioning, spoken language, and parental opinions were recorded. Principal component analysis was applied.
  
  
  
  Rates of impaired language, cerebral palsy, low academic skills, active epilepsy, and global intellectual deficiency were 49%, 32%, 28%, 11%, and 8%, respectively. All were highly correlated. Eventually, 59% of children were affected by at least 1 of the aforementioned conditions. In 30% of cases, the viewpoints of health practitioners and parents did not match.
  
  
  
  The prevalence of severe disabilities at 7 years after NAIS is low, but most children exhibit some impairment in developmental profile.
  
  
  
  ClinicalTrials.gov (NCT02511249), Programme Hospitalier de Recherche Clinique Régional (0308052), Programme Hospitalier de Recherche Clinique Interrégional (1008026), and EudraCT (2010-A00329-30).
authors.affiliation: Centre Hospitalier Universitaire (CHU) Saint-Étienne, French Center for Pediatric Stroke/Pediatric Physical and Rehabilitation Medicine Department and Institut national de la santé et de la recherche médicale Centre d'investigation Clinique (INSERM CIC) 1408, Saint-Étienne, France; INSERM and University of Lyon, Dysfonction vasculaire et hémostase (DVH) Team-Unité mixte de recherche (UMR) 1090 Sainbiose, Saint-Étienne, France. Electronic address: stephane.chabrier@chu-st-etienne.fr.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Chabrier
authors.affiliation: Centre Hospitalier Universitaire (CHU) Saint-Étienne, French Center for Pediatric Stroke/Pediatric Physical and Rehabilitation Medicine Department and Institut national de la santé et de la recherche médicale Centre d'investigation Clinique (INSERM CIC) 1408, Saint-Étienne, France.
authors.forename: Emeline
authors.initials: E
authors.lastname: Peyric
authors.affiliation: Centre Hospitalier Universitaire (CHU) Saint-Étienne, French Center for Pediatric Stroke/Pediatric Physical and Rehabilitation Medicine Department and Institut national de la santé et de la recherche médicale Centre d'investigation Clinique (INSERM CIC) 1408, Saint-Étienne, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Drutel
authors.affiliation: Centre Hospitalier Universitaire (CHU) Saint-Étienne, French Center for Pediatric Stroke/Pediatric Physical and Rehabilitation Medicine Department and Institut national de la santé et de la recherche médicale Centre d'investigation Clinique (INSERM CIC) 1408, Saint-Étienne, France.
authors.forename: Johanna
authors.initials: J
authors.lastname: Deron
authors.affiliation: Assistance publique-Hôpitaux de Paris (AP-HP), French Center for Pediatric Stroke/Pediatric Neurology Department, University Hospital Necker-Enfants Malades, Paris, France; INSERM and University of Paris 5, Thérapeutiques innovantes en hémostase-UMRS1140, Paris, France.
authors.forename: Manoëlle
authors.initials: M
authors.lastname: Kossorotoff
authors.affiliation: Physical and Rehabilitation Medicine Department, L'Université Nantes Angers le Mans (LUNAM) CHU Angers, Angers, France; Laboratoire Angevin de Recherche en Ingénierie des systèmes (LARIS)-EA7315, LUNAM Université Angers, Angers, France.
authors.forename: Mickaël
authors.initials: M
authors.lastname: Dinomais
authors.affiliation: Pediatrics Department, Centre hospitalier (CH) Côte-Basque, Bayonne, France.
authors.forename: Leila
authors.initials: L
authors.lastname: Lazaro
authors.affiliation: Pediatrics and Medical Genetics Deparment, CHU Brest, Brest, France.
authors.forename: Jérémie
authors.initials: J
authors.lastname: Lefranc
authors.affiliation: INSERM and University of Lyon, Dysfonction vasculaire et hémostase (DVH) Team-Unité mixte de recherche (UMR) 1090 Sainbiose, Saint-Étienne, France; Dynamique des capacités humaines et des conduites de santé -Laboratory Epsylon EA4556, Université Montpellier 3, Montpellier, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Thébault
authors.affiliation: Mines Alès, Laboratoire de génie informatique et d'ingénierie de production (LG2IP), Nîmes, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Dray
authors.affiliation: Pediatric Neurology, Pediatric Subspecialties Service, Children's Hospital, Geneva University Hospital, Geneva, Switzerland.
authors.forename: Joel
authors.initials: J
authors.lastname: Fluss
authors.affiliation: Centre Hospitalier Universitaire (CHU) Saint-Étienne, French Center for Pediatric Stroke/Pediatric Physical and Rehabilitation Medicine Department and Institut national de la santé et de la recherche médicale Centre d'investigation Clinique (INSERM CIC) 1408, Saint-Étienne, France; INSERM and University of Lyon, Dysfonction vasculaire et hémostase (DVH) Team-Unité mixte de recherche (UMR) 1090 Sainbiose, Saint-Étienne, France.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Renaud
authors.affiliation: Laboratoire Angevin de Recherche en Ingénierie des systèmes (LARIS)-EA7315, LUNAM Université Angers, Angers, France; Neuropediatrics Department, LUNAM CHU Angers, Angers, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Nguyen The Tich
mesh_terms: D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000453:epidemiology / Q000209:etiology*; D004827:Epilepsy / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D020521:Stroke / Q000150:complications*