title: Identification of three cannabimimetic indazole and pyrazole derivatives, APINACA 2H-indazole analogue, AMPPPCA, and 5F-AMPPPCA.
abstract: This paper reports analytical properties of three cannabimimetic indazole and pyrazole derivatives seized from a clandestine laboratory. These three new synthetic cannabinoids include N-(1-adamantyl)-2-pentyl-2H-indazole-3-carboxamide (APINACA 2H-indazole analogue, 1), N-(1-adamantyl)-4-methyl-1-pentyl-5-phenyl-1H-pyrazole-3-carboxamide (AMPPPCA, 2), and N-(1-adamantyl)-1-(5-fluoropentyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxamide (5F-AMPPPCA, 3). These compounds were identified by liquid chromatography-quadrupole time-of-flight-mass spectrometry (LC-QTOF-MS), gas chromatography-time-of-flight-mass spectrometry (GC-TOF-MS), and nuclear magnetic resonance (NMR) spectroscopy. No analytical properties and pharmacological activities about compounds 1-3 have appeared until now, making this the first report on these compounds. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Meng
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Qian
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Hua
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Cuimei
authors.initials: C
authors.lastname: Liu
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000032:analysis; D002186:Cannabinoids / Q000032:analysis*; D002853:Chromatography, Liquid; D008401:Gas Chromatography-Mass Spectrometry; D013287:Illicit Drugs / Q000032:analysis*; D007191:Indazoles / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011619:Psychotropic Drugs / Q000032:analysis*; D011720:Pyrazoles / Q000032:analysis*
chemical_list: D002186:Cannabinoids; D013287:Illicit Drugs; D007191:Indazoles; C000606545:N-(1-adamantyl)-1-pentylindazole-3-carboxamide; D011619:Psychotropic Drugs; D011720:Pyrazoles; D000218:Adamantane
keywords: 5F-AMPPPCA; AMPPPCA; APINACA 2H-indazole analogue; new psychoactive substance; synthetic cannabinoid