title: Computer aided morphometric analysis of oral leukoplakia and oral squamous cell carcinoma.
abstract: We compared the changes in the cells in the basal layer of normal mucosa, oral leukoplakia with dysplasia and different grades of oral squamous cell carcinoma (OSCC) using computer aided image analysis of tissue sections. We investigated three morphometric parameters: nuclear area (NA), cell area (CA) and their ratio (NA:CA). NA and NA:CA ratio showed a statistically significant increase from dysplasia to increasing grades of OSCC. Nuclear size was useful for differentiating normal tissue, potentially malignant leukoplakia and OSCC.
authors.affiliation: a Department of Oral and Maxillofacial Pathology , Mithila Minority Dental College and Hospital , Darbhanga , Bihar , India.
authors.forename: K
authors.initials: K
authors.lastname: Gupta
authors.affiliation: b Department of Oral Medicine and Radiology , Mithila Minority Dental College and Hospital , Darbhanga , Bihar , India.
authors.forename: J
authors.initials: J
authors.lastname: Gupta
authors.affiliation: c Endodontics, Mithila Minority Dental College and Hospital , Darbhanga , Bihar , India.
authors.forename: R
authors.initials: R
authors.lastname: Miglani
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007972:Leukoplakia, Oral / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology
keywords: OSCC; image analysis; leukoplakia; morphometry; oral squamous cell carcinoma