title: Lymphoepithelioma-like gastric carcinoma: A case report and review of the literature.
abstract: Lymphoepithelioma-like gastric carcinoma is a rare type of gastric cancer characterized by a carcinoma with intense stromal lymphocytic infiltration. Although lymphocytic infiltration is closely associated with Epstein-Barr virus (EBV) infection, concomitant occurrence with differentiated adenocarcinoma is relatively rare. The clinical manifestations of lymphoepithelioma-like gastric carcinoma (including EBV-positive and -negative forms) are similar to those of gastric cancer, and the diagnosis is based on pathologic, histologic, and immunohistochemical findings. This report describes the case of a 55-year-old female patient who presented with a 10-year history of recurrent and worsening abdominal pain and melena that had been occurring for 2 mo. An ulcerative lesion was detected in the stomach by endoscopic examination, which raised suspicion of early gastric cancer. A subsequent preoperative endoscopic biopsy showed adenocarcinoma, but the postoperative pathologic, histologic, and immunohistochemical analyses of the resected specimen revealed a final diagnosis of lymphoepithelioma-like gastric carcinoma.
authors.affiliation: Zhao-Hui Wang, Zhao Yuan, Department of Gastroenterology, Dalian Municipal Central Hospital, Dalian 116033, Liaoning Province, China.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Wang
authors.affiliation: Zhao-Hui Wang, Zhao Yuan, Department of Gastroenterology, Dalian Municipal Central Hospital, Dalian 116033, Liaoning Province, China.
authors.forename: Jun-Jun
authors.initials: JJ
authors.lastname: Zhao
authors.affiliation: Zhao-Hui Wang, Zhao Yuan, Department of Gastroenterology, Dalian Municipal Central Hospital, Dalian 116033, Liaoning Province, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Yuan
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005260:Female; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Epstein-Barr virus; Lymphoepithelioma-like carcinoma; Stomach neoplasms