title: Paediatric HIV infection: the potential for cure.
abstract: Recent anecdotal reports of HIV-infected children who received early antiretroviral therapy (ART) and showed sustained control of viral replication even after ART discontinuation have raised the question of whether there is greater intrinsic potential for HIV remission, or even eradication ('cure'), in paediatric infection than in adult infection. This Review describes the influence of early initiation of ART, of immune ontogeny and of maternal factors on the potential for HIV cure in children and discusses the unique immunotherapeutic opportunities and obstacles that paediatric infection may present.
authors.affiliation: Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Goulder
authors.affiliation: The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne 3000, Australia.|Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne 3004, Australia.
authors.forename: Sharon R
authors.initials: SR
authors.lastname: Lewin
authors.affiliation: Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK.
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Leitman
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D061345:Early Medical Intervention; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000635:transmission; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008213:Lymphocyte Activation / Q000276:immunology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000276:immunology; D013997:Time Factors
chemical_list: D057134:Antibodies, Neutralizing