title: Extended pelvic lymphadenectomy in patients with clinically localised prostate cancer: A prospective observational study.
abstract: OBJECTIVE
  To determine the frequency of lymph node involvement in patients with clinically localised prostate adenocarcinoma who had radical prostatectomy and extended pelvic lymphadenectomy.
  
  
  METHODS
  A prospective observational study was conducted on 137 patients with clinically localised prostate cancer of low, intermediate or high risk according to the D'Amico classification. All participants underwent radical prostatectomy plus extended pelvic lymphadenectomy in 3 reference centres in Bogota, Colombia, between 2013 and 2014. The following variables were assessed: age, prostate specific antigen levels, Gleason score of the biopsy, probability of lymph node involvement calculated with Partin tables and the histopathology result of the surgical specimen, with the definitive Gleason pattern and the total number of resected and involved lymph nodes per tumour, according to the territory of the dissection.
  
  
  RESULTS
  A total of 2,876 lymph nodes were extracted (an average of 20.99 lymph nodes per patient). There was lymph node involvement in 14 (10.22%) patients. The high-risk and intermediate-risk group presented lymph node metastases in 28.57% and 5.25%, respectively. There was no lymph node involvement in the low-risk group. Of the patients at risk of lymph node involvement (≥2% according to the Partin tables), 19.40% had lymph node metastases.
  
  
  CONCLUSIONS
  Lymph node involvement in our population is similar to that reported in the worldwide literature. Extended pelvic lymphadenectomy increased the probability of detecting lymph node metastases in our community.
authors.affiliation: Unidad de Urología, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá D.C., Colombia. Electronic address: ramos-j@javeriana.edu.co.
authors.forename: J G
authors.initials: JG
authors.lastname: Ramos
authors.affiliation: Departamento de Urología, Hospital Universitario de la Fundación Santa Fe de Bogotá y Facultad de Medicina de la Universidad de los Andes, Bogotá D.C., Colombia.
authors.forename: J I
authors.initials: JI
authors.lastname: Caicedo
authors.affiliation: Unidad de Urología, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
authors.forename: J G
authors.initials: JG
authors.lastname: Cataño
authors.affiliation: Unidad de Urología, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
authors.forename: L G
authors.initials: LG
authors.lastname: Villarraga
authors.affiliation: Departamento de Urología, Hospital Universitario de la Fundación Santa Fe de Bogotá y Facultad de Medicina de la Universidad de los Andes, Bogotá D.C., Colombia.
authors.forename: C G
authors.initials: CG
authors.lastname: Trujillo
authors.affiliation: Departamento de Urología, Hospital Universitario de la Fundación Santa Fe de Bogotá y Facultad de Medicina de la Universidad de los Andes, Bogotá D.C., Colombia.
authors.forename: D
authors.initials: D
authors.lastname: Robledo
authors.affiliation: Departamento de Urología, Hospital Universitario de la Fundación Santa Fe de Bogotá y Facultad de Medicina de la Universidad de los Andes, Bogotá D.C., Colombia.
authors.forename: M
authors.initials: M
authors.lastname: Plata
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery*; D000328:Adult; D000368:Aged; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010388:Pelvis; D011446:Prospective Studies; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*
keywords: Cáncer de próstata; Linfadenectomía; Lymphadenectomy; Lymphocytic metastasis; Metástasis linfática; Prostate cancer; Prostatectomía radical; Radical prostatectomy