title: Primary prevention and treatment of venous thromboembolic events in patients with gastrointestinal cancers - Review.
abstract: Venous thromboembolism event (VTE) is a common and morbid complication in cancer patients. Patients with gastrointestinal cancers often suffer from symptomatic or incidental splanchnic vein thrombosis, impaired liver function and/or thrombocytopenia. These characteristics require a thorough risk/benefit evaluation for individual patients. Considering the risk factors for the development of VTE and bleeding events in addition to recent study results may be helpful for correct initiation of primary pharmacological prevention and treatment of cancer-associated thrombosis (CAT), preferably with low molecular weight heparins (LMWH). Whereas thromboprophylaxis is most often recommended in hospitalized surgical and non-surgical patients with malignancy, there is less agreement as to its duration. With regard to ambulatory cancer patients, the lack of robust data results in low grade recommendations against routine use of anticoagulant drugs. Anticoagulation with LMWH for the first months is the evidence-based treatment for acute CAT, but duration of secondary prevention and the drug of choice are unclear. Based on published guidelines and literature, this review will focus on prevention and treatment strategies of VTE in patients with gastrointestinal cancers.
authors.affiliation: Hanno Riess, Piet Habbel, Anja Jühling, Marianne Sinn, Uwe Pelzer, Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, 10117 Berlin, Germany.
authors.forename: Hanno
authors.initials: H
authors.lastname: Riess
authors.affiliation: Hanno Riess, Piet Habbel, Anja Jühling, Marianne Sinn, Uwe Pelzer, Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, 10117 Berlin, Germany.
authors.forename: Piet
authors.initials: P
authors.lastname: Habbel
authors.affiliation: Hanno Riess, Piet Habbel, Anja Jühling, Marianne Sinn, Uwe Pelzer, Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, 10117 Berlin, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Jühling
authors.affiliation: Hanno Riess, Piet Habbel, Anja Jühling, Marianne Sinn, Uwe Pelzer, Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, 10117 Berlin, Germany.
authors.forename: Marianne
authors.initials: M
authors.lastname: Sinn
authors.affiliation: Hanno Riess, Piet Habbel, Anja Jühling, Marianne Sinn, Uwe Pelzer, Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, 10117 Berlin, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Pelzer
keywords: Anticoagulation; Gastrointestinal cancer; Prophylaxis; Thromboembolism; Treatment