title: [Histological hanges in the placenta and vascularization of its villi in early- and late-onset preeclampsia].
abstract: OBJECTIVE
  to make a comparative histological study of the placenta and a morphometric analysis of its terminal villi in early- and late-onset preeclampsia.
  
  
  METHODS
  Placentae from patients whose pregnancy had been complicated by the development of early- (n=26) or late-onset (n=84) preeclampsia were examined. A control group comprised placentae from 28 patients with physiological pregnancy and no extragenital diseases. The authors made a comparative histological study of placental tissue and a morphometric analysis of the terminal villi using the sections immunohistochemically stained for CD31.
  
  
  RESULTS
  It was determined that there was a preponderance of branching angiogenesis in the preeclamptic chorionic villi and an increase in the number of syncytial nodules and microcysts in the septae in late-onset preeclampsia. Morphometric analysis of immunohistochemical placental specimens established a reduction in the sizes and vascularization indicators of terminal villi that determine the development of placental hypoxia and are more pronounced in cases of early-onset preeclampsia.
authors.affiliation: Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Shchegolev
authors.affiliation: Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Lyapin
authors.affiliation: Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia.
authors.forename: U N
authors.initials: UN
authors.lastname: Tumanova
authors.affiliation: Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia.
authors.forename: D N
authors.initials: DN
authors.lastname: Vodneva
authors.affiliation: Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia.
authors.forename: R G
authors.initials: RG
authors.lastname: Shmakov
mesh_terms: D000328:Adult; D017668:Age of Onset; D002824:Chorionic Villi / Q000473:pathology*; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology*; D006801:Humans; D000860:Hypoxia / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000473:pathology*; D010920:Placenta / Q000473:pathology; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000096:biosynthesis / Q000276:immunology; D011225:Pre-Eclampsia / Q000473:pathology*; D011247:Pregnancy
chemical_list: D019408:Platelet Endothelial Cell Adhesion Molecule-1