title: Nickel-catalyzed ortho-halogenation of unactivated (hetero)aryl C-H bonds with lithium halides using a removable auxiliary.
abstract: The first example of Ni-catalyzed halogenation of (hetero)aryl C-H bonds with lithium halides (LiX, X = Br, I, Cl) using PIP as a removable directing group is reported. This protocol provides an efficient access to ortho-halogenated (hetero)arenes with operational simplicity, good functional group tolerance, and large-scale synthesis.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, China. bfshi@zju.edu.cn.
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Zhan
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Hu
authors.forename: Bing-Feng
authors.initials: BF
authors.lastname: Shi