title: ATYPICAL HEMOLYTIC UREMIC SYNDROME IN AN ADULT SUCCESSFULLY TREATED WITH ECULIZUMAB.
abstract: Atypical Hemolytic Uremic Syndrome is a triad of microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure not associated with diarrhea. It is a rare condition associated with complement disorders in about 50 percent of cases. The first line of treatment is therapeutic plasma exchange. However, because clinical response to TPE varies, an anti-complement drug, eculizumab has been tried. We report a case of atypical HUS successfully treated with eculizumab.
authors.affiliation: Dr Chardoir is affiliated with the Louisiana State University Health Sciences Center at Shreveport Department of Pathology.
authors.forename: Catherine
authors.initials: C
authors.lastname: Chaudoir
authors.affiliation: Dr Ong is affiliated with the Louisiana State University Health Sciences Center at Shreveport Department of Pathology.
authors.forename: Menchu G
authors.initials: MG
authors.lastname: Ong
authors.affiliation: Dr. Gu is affiliated with the Louisiana State University Health Sciences Center at Shreveport Department of Pathology.
authors.forename: Xin
authors.initials: X
authors.lastname: Gu
authors.affiliation: Dr. Veillon is affiliated with the Louisiana State University Health Sciences Center at Shreveport Department of Pathology.
authors.forename: Diana
authors.initials: D
authors.lastname: Veillon
authors.affiliation: Dr. Cotelingam is affiliated with the Louisiana State University Health Sciences Center at Shreveport Department of Pathology.
authors.forename: James
authors.initials: J
authors.lastname: Cotelingam
mesh_terms: D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D065766:Atypical Hemolytic Uremic Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D010951:Plasma Exchange; D011697:Purpura, Thrombotic Thrombocytopenic
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C481642:eculizumab