title: Secondary Antibody Deficiency in Glucocorticoid Therapy Clearly Differs from Primary Antibody Deficiency.
abstract: The aim of this study was to identify characteristics of hypogammaglobulinemia secondary to glucocorticoid therapy and their value in the differential diagnosis to primary forms of antibody deficiency.
  
  
  
  We investigated prevalence and character of hypogammaglobulinemia in a cohort of 36 patients with giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) on glucocorticoid therapy in comparison to a gender- and age-matched cohort of hospital controls. We therefore determined serum immunoglobulin levels as well as B- and T cell-subsets in the peripheral blood of all participants. In addition, prior serum immunoglobulin levels and clinical data of the GCA and PMR patients were extracted from the electronic patient data-base.
  
  
  
  21/36 GCA/PMR patients on glucocorticoid treatment developed antibody deficiency. In 19 patients this included IgG and in 13 patients IgG was the only affected isotype. The reduction of IgG was persistent in nearly 50 % of these patients during the observed period. GCA/PMR patients had reduced circulating naive and transitional B cells (p = 0.0043 and p = 0.0002 respectively) while IgM, IgG and IgA memory B cells were preserved. Amongst T-cell subsets, we found a reduction of CD4 memory T cells (p < 0.0001), CD4 regulatory T cells (p = 0.0002) and few CD8 memory T-cell subtypes.
  
  
  
  Persistent humoral immunodeficiency occurs in about a quarter of GCA/PMR patients under glucocorticoid therapy. Because most patients have isolated IgG deficiency, preserved IgA production and class-switched memory B cells, by these markers this form of secondary hypogammaglobulinemia can be clearly distinguished from common variable immunodeficiency (CVID).
authors.affiliation: Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Breisacher Str. 117, 79106, Freiburg, Germany.
authors.forename: Clemens
authors.initials: C
authors.lastname: Wirsum
authors.affiliation: Division of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Glaser
authors.affiliation: Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Breisacher Str. 117, 79106, Freiburg, Germany.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Gutenberger
authors.affiliation: Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Breisacher Str. 117, 79106, Freiburg, Germany.
authors.forename: Baerbel
authors.initials: B
authors.lastname: Keller
authors.affiliation: Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Breisacher Str. 117, 79106, Freiburg, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Unger
authors.affiliation: Division of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
authors.forename: Reinhard E
authors.initials: RE
authors.lastname: Voll
authors.affiliation: Center for Medical Biometry and Medical Informatics, University Medical Center Freiburg, Stefan-Meier-Str. 26, 79104, Freiburg, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Vach
authors.affiliation: Eye Center, University of Freiburg, Killianstraße 5, 79106, Freiburg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ness
authors.affiliation: Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Breisacher Str. 117, 79106, Freiburg, Germany. klaus.warnatz@uniklinik-freiburg.de.
authors.forename: Klaus
authors.initials: K
authors.lastname: Warnatz
mesh_terms: D000361:Agammaglobulinemia / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology / Q000276:immunology; D000368:Aged; D000369:Aged, 80 and over; D016175:B-Lymphocyte Subsets / Q000276:immunology; D005260:Female; D013700:Giant Cell Arteritis / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D008875:Middle Aged; D011111:Polymyalgia Rheumatica / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use; D015995:Prevalence; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D005938:Glucocorticoids; D007136:Immunoglobulins; D011241:Prednisone
keywords: Common Variable Immunodeficiency; Diagnosis; Giant cell arteritis; Glucocorticoid; Hypogammaglobulinemia