title: Eosinopenia as a Predictive Factor of the Short-Term Risk of Mortality and Infection after Acute Cerebral Infarction.
abstract: BACKGROUND
  Eosinopenia has been shown to be a prognostic factor in bacteremia, chronic obstructive pulmonary disease, and myocardial infarction, but studies focusing on cerebral infarction are lacking.
  
  
  METHODS
  We conducted a retrospective study of 405 patients admitted to the Asahi General Hospital from June 2011 to September 2014 with a diagnosis of cerebral infarction within 24 hours after symptom onset. Differences in mortality, mortality associated with infection, and the prevalence of infection within 2 months of hospital admission were assessed between patients with and without eosinopenia at presentation.
  
  
  RESULTS
  Patients with eosinopenia had a significantly higher mortality rate (hazard ratio (HR) 2.54, 95% confidence interval (CI) 1.17-5.21, P = .01), mortality associated with infection (HR 28.7, 95% CI 4.9-542.2, P <.0001), and an increased prevalence of infection (HR 1.83, 95% CI 1.12-2.89, P = .01) than patients without eosinopenia. Patients with neutrophilia and eosinopenia showed a significantly higher mortality rate than patients without neutrophilia (HR 3.15, 95% CI 1.40-6.92, P = .007), whereas patients with neutrophilia without eosinopenia showed no significant difference in mortality compared with patients without neutrophilia (HR 1.57, 95% CI .56-3.93, P = .37). Eosinopenia was a significant risk factor in 2-month mortality rate in multivariate analyses (HR 2.34, 95% CI 1.05-4.95, P = .04).
  
  
  CONCLUSIONS
  Eosinopenia is a novel predictive factor for complications after acute cerebral infarction. Stroke patients with eosinopenia should be monitored carefully for infection.
authors.affiliation: Department of Internal Medicine, Asahi General Hospital, Chiba, Japan. Electronic address: ys-hori@umin.ac.jp.
authors.forename: Yusuke S
authors.initials: YS
authors.lastname: Hori
authors.affiliation: Department of Internal Medicine, Asahi General Hospital, Chiba, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kodera
authors.affiliation: Clinical Research Center, Chiba University Hospital, Chiba, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Internal Medicine, Asahi General Hospital, Chiba, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shiojiri
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000401:mortality*; D016009:Chi-Square Distribution; D003141:Communicable Diseases / Q000097:blood / Q000175:diagnosis / Q000401:mortality*; D004804:Eosinophils; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007958:Leukocyte Count; D007960:Leukocyte Disorders / Q000097:blood / Q000175:diagnosis / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils; D011237:Predictive Value of Tests; D015995:Prevalence; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
keywords: Cerebral infarction; eosinopenia; infection; predictive factor