title: Prognostic significance of standardised uptake value (SUVmax) measured on 18F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with small cell lung cancer.
abstract: Certain prognostic factors for small cell lung cancer (SCLC) have been validated, but the prognostic role of 18F-FDG PET/CT still remains unclear. The aim of this study was to evaluate the prognostic significance of 18F-FDG PET/CT in patients with SCLC. We reviewed 142 patients with pathologically proven SCLC who underwent pre-treatment 18F-FDG PET/CT. Standardised uptake value (SUVmax) and other potential prognostic variables were chosen for analysis. The mean age of the study population was 58.2 ± 10.1 years (range, 25-84), and 124 (87.3%) patients were men. The median SUVmaxvalue was 11.6 (4.0-29.3). Among the variables included in the univariate analysis, performance status (P = 0.001), disease stage (P < 0.001), administration of thoracic radiotherapy (TRT; P < 0.001), albumin level (P = 0.030) and LDH level (P < 0.001) showed prognostic significance. Further, multivariate analysis showed that performance status (P = 0.007), albumin level (P = 0.002), LDH level (P < 0.001) and administration of TRT (P = 0.001) were independent prognostic factors for survival. In conclusion, performance status, TRT, LDH level and albumin level were identified as important prognostic factors, while 18F-FDG PET/CT uptake of the primary lesions did not have any prognostic significance for survival in patients with SCLC.
authors.affiliation: Chest Diseases Clinic, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Yilmaz Demirci
authors.affiliation: Chest Diseases Clinic, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey.
authors.forename: Ü
authors.initials: Ü
authors.lastname: Yilmaz
authors.affiliation: Department of Nuclear Medicine, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Biner Uslu
authors.affiliation: Department of Statistics, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Dikmen
authors.affiliation: Chest Diseases Clinic, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Yılmaz
authors.affiliation: Chest Diseases Clinic, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Erdoğan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography; D011379:Prognosis; D019275:Radiopharmaceuticals; D011878:Radiotherapy; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism; D055752:Small Cell Lung Carcinoma / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy
chemical_list: D019275:Radiopharmaceuticals; D012709:Serum Albumin; D019788:Fluorodeoxyglucose F18; D005047:Etoposide; D016190:Carboplatin; D007770:L-Lactate Dehydrogenase; D002945:Cisplatin
keywords: 18F-fluorodeoxyglucose positron emission tomography/computed tomography; maximum standardised uptake value (SUVmax); prognosis; small cell lung cancer