title: Response to nebulized salbutamol versus combination with ipratropium bromide in children with acute severe asthma.
abstract: OBJECTIVE
  To compare the efficacy of nebulised salbutamol alone and in combination with ipratropium bromide in acute severe asthma in children.
  
  
  METHODS
  The randomised controlled trial was conducted at the National Institute of Child Health, Karachi, from October 2012 to March 2013, and comprised patients with acute severe asthma who were randomised into two equal groups. Group A patients received 3 doses of nebulised salbutamol alone (0.03 ml/kg/dose) at 15-minute intervals and Group B received 3 similar doses of salbutamol along with ipratropium (250 ug/dose). Acute severe asthma was categorised as serve exacerbation (clinical score >10) and moderate (5-10 score) based on Bentur Modification. Efficacy was measured after 5minutes of the last dose by change in severity score from severe exacerbation (baseline) to low score. SPSS 10 was used for statistical analysis.
  
  
  RESULTS
  There were two groups of 100(50%) patients each. The mean age in Group A was 9.1±3 years and 9.3±2.8 years in Group B. Male-Female ratio in Group A was 1.5:1 and in Group B it was 1.2:1. In Group B, 93(93%) children showed improvement in clinical score (<10 score) while it was 84(84%) in Group A. There was better response in clinical score in Group A than Group B, but it was not significant (p>0.05).
  
  
  CONCLUSIONS
  The combination of nebulised salbutamol along with ipratropium bromide in the treatment of acute asthma exacerbation was not superior to salbutamol alone.
authors.affiliation: National Institute of Child Health (NICH), Karachi, Pakistan.
authors.forename: Bilquis Naeem
authors.initials: BN
authors.lastname: Memon
authors.affiliation: National Institute of Child Health (NICH), Karachi, Pakistan.
authors.forename: Arit
authors.initials: A
authors.lastname: Parkash
authors.affiliation: National Institute of Child Health (NICH), Karachi, Pakistan.
authors.forename: Khalid Mahmood
authors.initials: KM
authors.lastname: Ahmed Khan
authors.affiliation: National Institute of Child Health (NICH), Karachi, Pakistan.
authors.forename: Murtaza Ali
authors.initials: MA
authors.lastname: Gowa
authors.affiliation: National Institute of Child Health (NICH), Karachi, Pakistan.
authors.forename: Chandra
authors.initials: C
authors.lastname: Bai
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000420:Albuterol / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use*; D008297:Male; D009330:Nebulizers and Vaporizers; D013224:Status Asthmaticus / Q000188:drug therapy*
chemical_list: D001993:Bronchodilator Agents; D009241:Ipratropium; D000420:Albuterol
keywords: Acute severe asthma, Bentur Modification, Salbutamol, Ipratropium, Neublization.