title: Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review.
abstract: Steroid sulfatase (STS) plays a momentous role in the conversion of sulfated steroids, which are biologically inactive, into biologically active un-sulfated steroid hormones, which support the development and growth of a number of hormone-dependent cancers, including breast cancer. Therefore, inhibitors of STS are supposed to be potential drugs for the treatment of breast and other steroid-dependent cancers. The present review concentrates on broad chemical classification of steroid sulfatase inhibitors. The inhibitors reviewed are classified into four main categories: Steroid sulfamate based inhibitors; Steroid non-sulfamate based inhibitors; Non-steroidal sulfamate based inhibitors; Non-steroidal non-sulfamate based inhibitors. A succinct overview of current treatment of cancer, estradiol precursors, STS enzyme and its role in breast cancer is herein described.
authors.affiliation: Department of Pharmaceutical Sciences and Drug Research, Pharmaceutical Chemistry Research Lab, Punjabi University, Patiala, 147002, India.
authors.forename: Ramanpreet
authors.initials: R
authors.lastname: Shah
authors.affiliation: Department of Pharmaceutical Sciences and Drug Research, Pharmaceutical Chemistry Research Lab, Punjabi University, Patiala, 147002, India.
authors.forename: Jatinder
authors.initials: J
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Sciences and Drug Research, Pharmaceutical Chemistry Research Lab, Punjabi University, Patiala, 147002, India. Electronic address: ddd300@gmail.com.
authors.forename: Dhandeep
authors.initials: D
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Sciences and Drug Research, Pharmaceutical Chemistry Research Lab, Punjabi University, Patiala, 147002, India.
authors.forename: Amteshwar Singh
authors.initials: AS
authors.lastname: Jaggi
authors.affiliation: Department of Pharmaceutical Sciences and Drug Research, Pharmaceutical Chemistry Research Lab, Punjabi University, Patiala, 147002, India.
authors.forename: Nirmal
authors.initials: N
authors.lastname: Singh
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000201:enzymology* / Q000378:metabolism; D013429:Sulfatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013451:Sulfonic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D004967:Estrogens; D013451:Sulfonic Acids; C005741:sulfamic acid; D013429:Sulfatases
keywords: Breast cancer; Non-steroidal non-sulfamate based inhibitors; Non-steroidal sulfamate based inhibitors; Steroid non-sulfamate based inhibitors; Steroid sulfamate based inhibitors; Sulfatase inhibitor's chemistry