title: The JAK/STAT pathway in obesity and diabetes.
abstract: Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.
authors.affiliation: St Vincent's Institute of Medical Research, Fitzroy, Australia.|Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Fitzroy, Australia.
authors.forename: Esteban N
authors.initials: EN
authors.lastname: Gurzov
authors.affiliation: St Vincent's Institute of Medical Research, Fitzroy, Australia.|Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Fitzroy, Australia.
authors.forename: William J
authors.initials: WJ
authors.lastname: Stanley
authors.affiliation: St Vincent's Institute of Medical Research, Fitzroy, Australia.|Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Fitzroy, Australia.
authors.forename: Evan G
authors.initials: EG
authors.lastname: Pappas
authors.affiliation: St Vincent's Institute of Medical Research, Fitzroy, Australia.|Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Fitzroy, Australia.
authors.forename: Helen E
authors.initials: HE
authors.lastname: Thomas
authors.affiliation: Hudson Institute of Medical Research, Clayton, Australia.|Department of Molecular and Translational Science, Monash University, Clayton, Australia.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Gough
mesh_terms: D000273:Adipose Tissue / Q000201:enzymology / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D003920:Diabetes Mellitus / Q000201:enzymology / Q000378:metabolism* / Q000628:therapy; D005234:Fatty Liver / Q000378:metabolism; D006801:Humans; D050417:Insulin-Secreting Cells / Q000201:enzymology / Q000378:metabolism; D053612:Janus Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051379:Mice; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism; D009765:Obesity / Q000201:enzymology / Q000378:metabolism* / Q000628:therapy; D050791:STAT Transcription Factors / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D050791:STAT Transcription Factors; D053612:Janus Kinases
keywords: JAK/STAT signaling pathway; adipose tissue; brain; cytokines; diabetes; hormones; liver; muscle; obesity; pancreas