title: Radiation Duration in Women with Cervical Cancer Treated with Primary Chemoradiation: A Population-Based Analysis.
abstract: This study examines factors associated with prolonged radiation duration and its impact on survival in women with cervical cancer treated with primary chemoradiation. Women in the National Cancer Database with stage IB2-IVA cervical cancer from 2003 to 2011 who received radiation and chemotherapy were included. Of 7209 women, who met inclusion criteria, 3401 (47.1%) and 3808 (52.8%) completed radiation in ≤ 8 and > 8 weeks, respectively. There was no overall survival difference for radiation duration ≤ 8 vs. > 8 weeks. Sensitivity analyses showed that inferior overall survival is only seen with radiation duration of > 10-12 weeks.
authors.affiliation: a Department of Obstetrics and Gynecology , College of Physicians and Surgeons, Columbia University , New York , NY , USA.|b Department of Epidemiology , Mailman School of Public Health, Columbia University , New York , NY , USA.|c Herbert Irving Comprehensive Cancer Center , College of Physicians and Surgeons, Columbia University , New York , NY , USA.
authors.forename: Ana I
authors.initials: AI
authors.lastname: Tergas
authors.affiliation: b Department of Epidemiology , Mailman School of Public Health, Columbia University , New York , NY , USA.|c Herbert Irving Comprehensive Cancer Center , College of Physicians and Surgeons, Columbia University , New York , NY , USA.|d Department of Medicine, College of Physicians and Surgeons , Columbia University , New York , NY , USA.
authors.forename: Alfred I
authors.initials: AI
authors.lastname: Neugut
authors.affiliation: a Department of Obstetrics and Gynecology , College of Physicians and Surgeons, Columbia University , New York , NY , USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: a Department of Obstetrics and Gynecology , College of Physicians and Surgeons, Columbia University , New York , NY , USA.
authors.forename: William M
authors.initials: WM
authors.lastname: Burke
authors.affiliation: b Department of Epidemiology , Mailman School of Public Health, Columbia University , New York , NY , USA.|c Herbert Irving Comprehensive Cancer Center , College of Physicians and Surgeons, Columbia University , New York , NY , USA.|d Department of Medicine, College of Physicians and Surgeons , Columbia University , New York , NY , USA.
authors.forename: Dawn L
authors.initials: DL
authors.lastname: Hershman
authors.affiliation: a Department of Obstetrics and Gynecology , College of Physicians and Surgeons, Columbia University , New York , NY , USA.|b Department of Epidemiology , Mailman School of Public Health, Columbia University , New York , NY , USA.|c Herbert Irving Comprehensive Cancer Center , College of Physicians and Surgeons, Columbia University , New York , NY , USA.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Wright
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000628:therapy*; D059248:Chemoradiotherapy; D015331:Cohort Studies; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000628:therapy*
keywords: Cervical Cancer; Health Sciences Research; Treatment