title: Impact of non-oncological factors on tumor recurrence after liver transplantation in hepatocellular carcinoma patients.
abstract: Hepatocellular carcinoma (HCC) is the most common primary neoplasm of the liver and is one of the leading causes of cancer-related death worldwide. Liver transplantation (LT) has become one of the best curative therapeutic options for patients with HCC, although tumor recurrence after LT is a major and unaddressed cause of mortality. Furthermore, the factors that are associated with recurrence are not fully understood, and most previous studies have focused on the biological properties of HCC, such as the number and size of the HCC nodules, the degree of differentiation, the presence of hepatic vascular invasion, elevated serum levels of alpha-fetoprotein, and the tumor stage outside of the Milan criteria. Thus, little attention has been given to factors that are not directly related to HCC (i.e., "non-oncological factors"), which have emerged as predictors of tumor recurrence. This review was performed to assess the effects of non-oncological factors on tumor recurrence after LT. The identification of these factors may provide new research directions and clinical strategies for the prophylaxis and surveillance of tumor recurrence after LT, which can help reduce recurrence and improve patient survival.
authors.affiliation: Xiang-Qian Gu, Organ Transplant Center, The First Central Clinical College, Tianjin Medical University, Tianjin 300192, China.
authors.forename: Xiang-Qian
authors.initials: XQ
authors.lastname: Gu
authors.affiliation: Xiang-Qian Gu, Organ Transplant Center, The First Central Clinical College, Tianjin Medical University, Tianjin 300192, China.
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Zheng
authors.affiliation: Xiang-Qian Gu, Organ Transplant Center, The First Central Clinical College, Tianjin Medical University, Tianjin 300192, China.
authors.forename: Da-Hong
authors.initials: DH
authors.lastname: Teng
authors.affiliation: Xiang-Qian Gu, Organ Transplant Center, The First Central Clinical College, Tianjin Medical University, Tianjin 300192, China.
authors.forename: Ji-San
authors.initials: JS
authors.lastname: Sun
authors.affiliation: Xiang-Qian Gu, Organ Transplant Center, The First Central Clinical College, Tianjin Medical University, Tianjin 300192, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000276:immunology / Q000473:pathology / Q000601:surgery* / Q000821:virology; D015897:Comorbidity; D006509:Hepatitis B / Q000150:complications; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008113:Liver Neoplasms / Q000276:immunology / Q000473:pathology / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D009364:Neoplasm Recurrence, Local; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents
keywords: Deceased donor; Hepatocellular carcinoma; Immunosuppressive agents; Liver transplantation; Living donor; Recurrence