title: Altered isotope charge distribution of acetylcholine neurotransmitter and Myasthenia Gravis.
abstract: Acetylcholine (ACh) is a central neurotransmitter that is used for signal transmission among neurons. For signal transmission in neurons, a neurotransmitter must bind to its receptor in order to produce an action potential. It is known that in Myasthenia Gravis (MG) cases, autoantibodies could block this binding. In the future, the treatment of MG could be achieved via modulation of molecular interaction between ACh and acetylcholine receptor (AChR). This study suggests that if an atom on a ligand (i.e. a neurotransmitter) is replaced with its isotope, it may cause charge redistribution such as that the binding between ligand and its receptor may be improved. Hence suggesting that with replacement of atoms with their isotopes in any biologically important ligand could alter its affinity towards its corresponding receptor, which would have a wide array of applications in medicine.
authors.affiliation: Inonu University, Physics Department, 44280 Malatya, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Bayri
authors.affiliation: Inonu University, Psychiatry Department, 44280 Malatya, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Unal
authors.affiliation: Inonu University, Physics Department, 44280 Malatya, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Altin
authors.affiliation: Inonu University, Physics Department, 44280 Malatya, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Bulut
authors.affiliation: Inonu University, Department of Molecular Biology and Genetics, 44280 Malatya, Turkey.
authors.forename: B E
authors.initials: BE
authors.lastname: Dayanc
mesh_terms: D000109:Acetylcholine / Q000737:chemistry* / Q000378:metabolism*; D001665:Binding Sites; D003198:Computer Simulation; D007554:Isotopes / Q000737:chemistry*; D008956:Models, Chemical; D008958:Models, Molecular; D058990:Molecular Targeted Therapy / Q000379:methods; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D011950:Receptors, Cholinergic / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D007554:Isotopes; D018377:Neurotransmitter Agents; D011950:Receptors, Cholinergic; D000109:Acetylcholine