title: [The First Step Aiming at the Prevention of Hypertension and Atherosclerosis. Identification of Individuals at High Risk of Hypertension].
abstract: Hypertension is an established risk factor of cardiovascular morbidity and mortality. Although antihypertensive treatment reduces the risk of cardiovascular disease, it is impossible to identify all hypertensive subjects among the general population and to manage them in medical facilities considering the huge number of people with hypertension. Furthermore, more than half of cardiovascular events occur in individuals with mild hypertension or in those with a lower blood pressure. In this context, primary prevention of hypertension is an important public health problem. We investigated predictive values of several possible risk factors of hypertension in a general normotensive population. Normotensive subjects who visited our hospital for a physical checkup were enrolled and followed up for 4-5 years, with the endpoint being the development of hypertension. Each factor of metabolic syndrome was closely associated with the future onset of hypertension in subjects without hypertension, and the risk of hypertension markedly increased with overlapping metabolic disorders in individuals. Similarly, serum uric acid, the glomerular filtration rate, urinary albumin (even within the normal range), and brachial-ankle pulse wave velocity were independent risk factors of hypertension. These factors were also independent determinants of a future increase in the systolic blood pressure. An intensive targeted strategy focused on identified individuals at highest risk of developing hypertension is an attractive approach for the primary prevention of hypertension. [Review].
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Dohi
mesh_terms: D000419:Albuminuria; D055109:Ankle Brachial Index; D050197:Atherosclerosis / Q000517:prevention & control*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000517:prevention & control*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011237:Predictive Value of Tests; D011322:Primary Prevention / Q000379:methods*; D063177:Pulse Wave Analysis; D012306:Risk; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D014527:Uric Acid