title: Single oral dose safety of D-allulose in dogs.
abstract: Healthy dogs were administered acute oral doses of D-allulose (also called D-psicose) to evaluate its toxicity. Six dogs received oral doses of either a placebo or D-allulose solution (1 and 4 g/kg) on three different study days. One dog experienced vomiting, and five dogs showed transient diarrhea when 4 g/kg of D-allulose was administered. All dogs were active and had a good appetite throughout the study period. Blood glucose concentration slightly decreased without a rise in plasma insulin concentration 2 hr after D-allulose administration. Plasma alkaline phosphatase activities showed a mild increase between 12 and 48 hr after D-allulose administration. These data suggested that a single oral dose of D-allulose does not show severe toxicity in dogs.
authors.affiliation: Joint Department of Veterinary Medicine, Applied Biological Sciences, Gifu University, Gifu, Japan.
authors.forename: Naohito
authors.initials: N
authors.lastname: Nishii
authors.forename: Toru
authors.initials: T
authors.lastname: Nomizo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takashima
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Matsubara
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tokuda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kitagawa
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003967:Diarrhea / Q000139:chemically induced / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced; D004285:Dogs; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects*; D007328:Insulin / Q000097:blood; D008297:Male; D013549:Sweetening Agents / Q000008:administration & dosage / Q000009:adverse effects*; D014839:Vomiting / Q000139:chemically induced / Q000662:veterinary
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013549:Sweetening Agents; C003243:psicose; D005632:Fructose