title: Low-profile versus standard-profile multibranched thoracoabdominal aortic stent grafts.
abstract: OBJECTIVE
  This study compared midterm results using low-profile stent grafts (LPSGs; 18F) and standard-profile stent grafts (SPSGs; 22F-24F) for endovascular pararenal and thoracoabdominal aortic aneurysm (TAAA) repair.
  
  
  METHODS
  From July 2005 to March 2015, 134 asymptomatic patients underwent endovascular repair of a pararenal or TAAA using multibranched aortic stent grafts. In March 2011, we started using a LPSG with nitinol stents and thin-walled polyester fabric. Prospectively collected data on operative repair, complications, and outcomes were compared between the two groups.
  
  
  RESULTS
  LPSGs were used in 37 patients (8 women [21.6%]; mean ± standard deviation age, 72.5 ± 8 years) and SPSGs in 97 patients (25 [26%] women; mean age, 73 ± 8 years). Medical comorbidities, aneurysm size, and aneurysm extent were similar in the LPSG and SPSG groups. Mean follow-up time was longer in the SPSG group (3.1 ± 2 years) than in the LPSG group (1.3 ± 0.9 years; P < .001). Operative time, renal failure, stroke, myocardial infarction, and perioperative death were not significantly different between the two groups (P > .05). Aneurysm-related death, rupture, stent graft migration, type I or III endoleaks, aneurysm enlargement >5 mm, branch vessel occlusion, and reintervention rates were similar between the two groups (P > .05). However, the combined outcome of conduit use or access artery injury occurred at a lower rate in the LPSG group than in the SPSG group (16% vs 36%; P = .03). Women experienced significantly higher rates of conduit use and access artery injury than men after repair with SPSGs (64% vs 26%, respectively; P = .001) but similar rates after repair with the LPSG (25% vs 14%, respectively; P = .45).
  
  
  CONCLUSIONS
  LPSGs had similar safety profile and midterm outcomes compared with the SPSGs for treatment of pararenal and TAAA. The substitution of LPSGs for SPSGs lowered the number of patients who required conduit insertion to avoid access artery injury, especially in women, thereby reducing an otherwise striking gender difference.
authors.affiliation: Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, Calif.
authors.forename: Bala
authors.initials: B
authors.lastname: Ramanan
authors.affiliation: Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, Calif.
authors.forename: Charlene C
authors.initials: CC
authors.lastname: Fernandez
authors.affiliation: Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, Calif.
authors.forename: Julia D
authors.initials: JD
authors.lastname: Sobel
authors.affiliation: Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, Calif.
authors.forename: Warren J
authors.initials: WJ
authors.lastname: Gasper
authors.affiliation: Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, Calif.
authors.forename: Shant M
authors.initials: SM
authors.lastname: Vartanian
authors.affiliation: Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, Calif.
authors.forename: Linda M
authors.initials: LM
authors.lastname: Reilly
authors.affiliation: Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, Calif.
authors.forename: Timothy A M
authors.initials: TA
authors.lastname: Chuter
authors.affiliation: Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, Calif. Electronic address: jade.hiramoto@ucsf.edu.
authors.forename: Jade S
authors.initials: JS
authors.lastname: Hiramoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000497:Alloys; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D005260:Female; D054625:Healthcare Disparities; D006801:Humans; D008297:Male; D008875:Middle Aged; D011091:Polyesters; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D011474:Prosthesis Design; D012307:Risk Factors; D012495:San Francisco; D012737:Sex Factors; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000497:Alloys; D011091:Polyesters; C013616:nitinol