title: Cytofunctional changes in nasal ciliated cells in patients treated with hyaluronate after nasal surgery.
abstract: BACKGROUND
  Hyaluronic acid (HA) plays a significant role in tissue repair of mucosal surfaces and, consequently, in surgical injury remodelling of nasal mucosa.
  
  
  OBJECTIVE
  To assess the effect of high-molecular-weight HA administered by aerosol on the morphofunctional recovery of ciliated cells damaged by surgical trauma.
  
  
  METHODS
  A single-blind, prospective, randomized trial was carried out with 94 patients who were randomly assigned, after endoscopic turbinoplasty, either to treatment with nasal saline solution irrigation (control group, n = 47) or to treatment with nasal douches based on high concentration (9 mg) and high-molecular-weight sodium hyaluronate (active treatment group, n = 47). All the patients were evaluated by using nasal fiberendoscopy, mucociliary transport time, nasal cytologic test, and a visual analog scale in terms of symptoms before and at 2 and 4 weeks after surgery.
  
  
  RESULTS
  Visual analog scale values were significantly lower in the active treatment (AT) group at week 2 regarding each individual symptom. Mucociliary transport time was significantly reduced in patients in the AT group but only 1 month after surgery. Both the percentage of cellular impairments and the number of cells with hyperchromatic supranuclear stria showed significant improvements in the AT group in all postsurgery evaluations (p < 0.05).
  
  
  CONCLUSIONS
  Intranasal use of sodium hyaluronate in patients who underwent functional nasal surgery improved both mucociliary clearance and nasal mucosa regeneration due to a faster recovery of the impaired ciliated cells.
authors.affiliation: Department of Otorhinolaryngology, University of Foggia, Foggia, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Cassano
authors.forename: Giuseppe Maria
authors.initials: GM
authors.lastname: Russo
authors.forename: Carla
authors.initials: C
authors.lastname: Granieri
authors.forename: Pasquale
authors.initials: P
authors.lastname: Cassano
mesh_terms: D000293:Adolescent; D000328:Adult; D002923:Cilia / Q000187:drug effects* / Q000473:pathology; D004724:Endoscopy; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects; D055556:Nasal Lavage; D009297:Nasal Mucosa / Q000187:drug effects* / Q000473:pathology; D011446:Prospective Studies; D012225:Rhinoplasty; D007507:Therapeutic Irrigation; D014945:Wound Healing; D055815:Young Adult
chemical_list: D006820:Hyaluronic Acid