title: [Termination of pregnancy: A survey about its evolution in French perinatal centres].
abstract: BACKGROUND
  Termination of pregnancy (TOP) is regulated by French law for decades. Indications of TOP may vary depending on progress performed in perinatal medicine and in diagnosis of fetal anomalies, and also according to the way malformations are perceived in society.
  
  
  OBJECTIVE
  To determine whether the frequency and indications of TOP had varied in the Lorraine Centre for Perinatal Diagnosis from 2000 to 2012.
  
  
  METHODS
  Retrospective study performed on a randomized sample of medical files presented in the Lorraine Centre for Perinatal Diagnosis in years 2000, 2006 and 2012. We analyzed the number of files presented by parents-to-be, the indication motivating TOP, general characteristics of both pregnancies and mothers. We also performed a prospective enquiry among the French Centres for Perinatal Diagnosis in order to determine national rates.
  
  
  RESULTS
  General characteristics of mothers and pregnancies were similar from 2002 to 2012. No modification in indications of TOP was measured. In Lorraine, most TOPs were performed for chromosomal abnormality. On the national level, centres for perinatal diagnosis received more requests for TOPs in the study period. There were also more TOPs for non-lethal fetal anomalies, and parents refusing TOPs though the centres had agreed with its indication.
  
  
  CONCLUSIONS
  The national trends were not measured in Lorraine region.
authors.affiliation: Université Claude-Bernard - Lyon I, UFR Lyon-Est, 69008 Lyon, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Layer Charpin
authors.affiliation: Centre pluridisciplinaire de diagnostic prénatal de Lorraine, 54000 Nancy, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Miton
authors.affiliation: Centre pluridisciplinaire de diagnostic prénatal de Lorraine, 54000 Nancy, France; Centre hospitalier régional universitaire de Nancy, service d'épidémiologie périnatale, 54000 Nancy, France; Centre hospitalier régional universitaire de Besançon, hôpital Jean-Minjoz, médecine pédiatrique, 2, boulevard Flemming, 25030 Besançon cedex, France. Electronic address: r.vieux@chu-besancon.fr.
authors.forename: Rachel
authors.initials: R
authors.lastname: Vieux
mesh_terms: D000023:Abortion Applicants / Q000523:psychology / Q000706:statistics & numerical data; D000025:Abortion, Eugenic / Q000706:statistics & numerical data; D000028:Abortion, Induced / Q000706:statistics & numerical data / Q000639:trends*; D000293:Adolescent; D000328:Adult; D002648:Child; D025063:Chromosome Disorders / Q000175:diagnosis / Q000196:embryology / Q000453:epidemiology; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000196:embryology / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008430:Maternal-Child Health Centers / Q000706:statistics & numerical data*; D008875:Middle Aged; D009042:Motivation; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011446:Prospective Studies; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D016312:Treatment Refusal; D055815:Young Adult