title: Fatigue among patients with brain tumors.
abstract: Fatigue is a ubiquitous and an extremely distressing symptom among patients with brain tumors (BT), particularly those with high-grade gliomas. The pathophysiology of cancer-related fatigue (CRF) in the context of patients with BT is multifactorial and complex, involving biological, behavioral, medical and social factors. The etiology of CRF in the general oncology population is pointing to the role of inflammatory cytokines as a key factor in the genesis of CRF, but this research is currently limited in the setting of BT. CRF should be screened, assessed and managed according to clinical practice guidelines. Fatigue has recently emerged as a strong, independent prognostic factor for survival that provides incremental prognostic value to the traditional markers of prognosis in recurrent high-grade gliomas. Therefore, strategies to treat fatigue warrant investigation, not only to improve the QOL of a group of patients with often limited life expectancy, but also possibly to optimize survival.
authors.affiliation: Cancer Survivorship & Rehabilitation, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Assistant Clinical Professor, Health Sciences, UCLA, 8700 Beverly Boulevard, AC 1109 Los Angeles, 90048, USA.
authors.forename: Arash
authors.initials: A
authors.lastname: Asher
authors.affiliation: Department of Palliative, Rehabilitation & Integrative Medicine, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1414, Houston, TX 77030, USA.
authors.forename: Jack B
authors.initials: JB
authors.lastname: Fu
authors.affiliation: Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Bailey
authors.affiliation: Department of Rehabilitation, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Hughes
mesh_terms: D001932:Brain Neoplasms / Q000150:complications*; D005221:Fatigue / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D005910:Glioma / Q000150:complications*; D006801:Humans; D011379:Prognosis; D011788:Quality of Life; D012307:Risk Factors; D015996:Survival Rate
keywords: brain tumor; cancer-related fatigue; fatigue