title: [Lipid peroxidation in cardiac mitochondrial fraction of rats exposed to different supplementation with polyunsaturated fatty acids].
abstract: The effect of diet supplementation with polyunsaturated fatty acids (PUFAs) used at different ratios of w-6/w-3 was studied on the content of primary (diene conjugates, DC; triene conjugates, TC), secondary (ketodienes, CD; coupled trienes, CT; TBA-active products) and terminal (Schiff bases) lipid peroxidation products (LPO) and generation of superoxide anion-radical in rat heart mitochondrial fraction. It was shown that diet supplementation with high doses of w-6 or w-3 PUFAs increased the content of primary, secondary and terminal LPO in rat heart mitochondrial fraction. Llipid peroxidation was accompanied by the intensification of superoxide anion-radical generation in rat heart mitochondrial fraction. During diet consumption with the PUFAs leading factor affecting the intensity of lipoperoxidation in rat heart mitochondria is fatty acid composition, rather than the level of their saturation.
authors.affiliation: Fedkovich Chernivtsi National University, Chernivtsi, Ukraine.
authors.forename: O V
authors.initials: OV
authors.lastname: Ketsa
authors.affiliation: Fedkovich Chernivtsi National University, Chernivtsi, Ukraine.
authors.forename: I O
authors.initials: IO
authors.lastname: Shmarakov
authors.affiliation: Fedkovich Chernivtsi National University, Chernivtsi, Ukraine.
authors.forename: M M
authors.initials: MM
authors.lastname: Marchenko
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D043371:Fatty Acids, Omega-6 / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008929:Mitochondria, Heart / Q000378:metabolism*; D051381:Rats
chemical_list: D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6
keywords: heart; lipid peroxidation; mitochondrial fraction; polyunsaturated fatty acids; superoxide anion-radical