title: The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles.
abstract: miR-143 and miR-145 have been widely described as tumor suppressors. Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. Understanding the part played by the miR-143/miR-145 cluster in the tumor microenvironment is essential for the development of future miRNA-related therapies.
authors.affiliation: Instituto de Investigação e Inovação em Saúde/Institute for Research and Innovation in Health (I3S), University of Porto, 4200-135, Porto, Portugal. ines.almeida@ineb.up.pt.|Instituto de Engenharia Biomédica (INEB), University of Porto, 4200-135, Porto, Portugal. ines.almeida@ineb.up.pt.
authors.forename: Maria Inês
authors.initials: MI
authors.lastname: Almeida
authors.affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.|Center for RNAi and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
authors.forename: George Adrian
authors.initials: GA
authors.lastname: Calin
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D059016:Tumor Microenvironment / Q000235:genetics*
chemical_list: C542359:MIRN143 microRNA, human; C541010:MIRN145 microRNA, human; D035683:MicroRNAs