title: Impact of chronobiology on neuropathic pain treatment.
abstract: Inflammatory pain exhibits circadian rhythmicity. Recently, a distinct diurnal pattern has been described for peripheral neuropathic conditions. This diurnal variation has several implications: advancing understanding of chronobiology may facilitate identification of new and improved treatments; developing pain-contingent strategies that maximize treatment at times of the day associated with highest pain intensity may provide optimal pain relief as well as minimize treatment-related adverse effects (e.g., daytime cognitive dysfunction); and consideration of the impact of chronobiology on pain measurement may lead to improvements in analgesic study design that will maximize assay sensitivity of clinical trials. Recent and ongoing chronobiology studies are thus expected to advance knowledge and treatment of neuropathic pain.
authors.affiliation: Department of Anesthesiology, Queen's University,76 Stuart St, Kingston, Ontario, K7L 2V7, Canada.|Department of Perioperative Medicine, Queen's University,76 Stuart St, Kingston, Ontario, K7L 2V7, Canada.|Department of Biomedical & Molecular Sciences, Queen's University,76 Stuart St, Kingston, Ontario, K7L 2V7, Canada.
authors.forename: Ian
authors.initials: I
authors.lastname: Gilron
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D009437:Neuralgia / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy*; D010147:Pain Measurement; D058748:Pain Perception / Q000187:drug effects / Q000502:physiology
chemical_list: D000700:Analgesics
keywords: circadian rhythms; clinical trials; diurnal variation; neuropathic pain; nocturnal pain