title: Does the etiology of cardiac amyloidosis determine the myocardial uptake of [18F]-NaF PET/CT?
abstract: Cardiac amyloidosis (CA) leads to variable degrees of myocardial infiltration with a final echocardiographic phenotype of "hypertrophy." Although many non-invasive imaging techniques (MRI, CT, scintigraphy, PET) are useful, the definitive diagnosis is still based on myocardial histology. We explored the possible role of [18F]-NaF PET/CT in the diagnosis of this disease in two cases with wild-type (ATTRwt) or mutant (ATTRm) Ile68Leu transthyretin (TTR)-related CA.
authors.affiliation: Cardio-Thoraco-Vascular Department, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy. christian.gagliardi@hotmail.it.
authors.forename: Christian
authors.initials: C
authors.lastname: Gagliardi
authors.affiliation: Nuclear Medicine Unit, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Tabacchi
authors.affiliation: Nuclear Medicine Unit, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Rachele
authors.initials: R
authors.lastname: Bonfiglioli
authors.affiliation: Nuclear Medicine Unit, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Diodato
authors.affiliation: Nuclear Medicine Unit, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Nanni
authors.affiliation: Nuclear Medicine Unit, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Guidalotti
authors.affiliation: Cardio-Thoraco-Vascular Department, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Lorenzini
authors.affiliation: PET Radiopharmacy, Nuclear Medicine Unit, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Lodi
authors.affiliation: Cardio-Thoraco-Vascular Department, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Agnese
authors.initials: A
authors.lastname: Milandri
authors.affiliation: Cardio-Thoraco-Vascular Department, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Rapezzi
authors.affiliation: Nuclear Medicine Unit, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Fanti
mesh_terms: D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism*; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism*; D003937:Diagnosis, Differential; D006801:Humans; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals
keywords: PET/CT imaging; [18F]-NaF PET/CT; cardiac amyloidosis; cardiomyopathy