title: Plasma phthalate and bisphenol a levels and oxidant-antioxidant status in autistic children.
abstract: Phthalates and bisphenol A (BPA) are endocrine disruting chemicals (EDCs) that are suggested to exert neurotoxic effects. This study aimed to determine plasma phthalates and BPA levels along with oxidant/antioxidant status in autistic children [n=51; including 12 children were diagnosed with "Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS)]. Plasma levels of BPA, di (2-ethylhexyl)-phthalate (DEHP) and its main metabolite mono (2-ethylhexyl)-phthalate (MEHP); thiobarbituric acid reactive substance (TBARS) and carbonyl groups; erythrocyte glutathione peroxidase (GPx1), thioredoxin reductase (TrxR), catalase (CAT), superoxide dismutase (SOD) and glutathione reductase (GR) activities and glutathione (GSH) and selenium levels were measured. Plasma BPA levels of children with PDD-NOS were significantly higher than both classic autistic children and controls (n=50). Carbonyl, selenium concentrations and GPx1, SOD and GR activities were higher (p<0.05); CAT activity was markedly lower in study group. BPA exposure might be associated with PDD-NOS. Intracellular imbalance between oxidant and antioxidant status might facilitate its neurotoxicity.
authors.affiliation: Erciyes University Faculty of Medicine, Department of Pediatrics, Social Pediatrics Unit, Kayseri 38039, Turkey. Electronic address: medakondolot@gmail.com.
authors.forename: Meda
authors.initials: M
authors.lastname: Kondolot
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Pediatrics, Social Pediatrics Unit, Developmental Pediatrics Unit, Ankara 06100, Turkey.
authors.forename: Elif N
authors.initials: EN
authors.lastname: Ozmert
authors.affiliation: Hacettepe University Faculty of Pharmacy, Department of Toxicology, Ankara 06100, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Ascı
authors.affiliation: Hacettepe University Faculty of Pharmacy, Department of Toxicology, Ankara 06100, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Erkekoglu
authors.affiliation: Erciyes University Faculty of Medicine, Department of Child Psychiatry, Kayseri 38039, Turkey.
authors.forename: Didem B
authors.initials: DB
authors.lastname: Oztop
authors.affiliation: Erciyes University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Neurology, Kayseri 38039, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Gumus
authors.affiliation: Hacettepe University Faculty of Pharmacy, Department of Toxicology, Ankara 06100, Turkey. Electronic address: belmagumusel@yahoo.com.
authors.forename: Belma
authors.initials: B
authors.lastname: Kocer-Gumusel
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Pediatrics, Social Pediatrics Unit, Developmental Pediatrics Unit, Ankara 06100, Turkey.
authors.forename: Kadriye
authors.initials: K
authors.lastname: Yurdakok
mesh_terms: D001321:Autistic Disorder / Q000097:blood* / Q000378:metabolism; D001559:Benzhydryl Compounds / Q000097:blood*; D002374:Catalase / Q000378:metabolism; D002648:Child; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D004785:Environmental Pollutants / Q000097:blood*; D006801:Humans; D010636:Phenols / Q000097:blood*; D010795:Phthalic Acids / Q000097:blood*; D012643:Selenium / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013880:Thioredoxin-Disulfide Reductase / Q000378:metabolism; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D002374:Catalase; D004785:Environmental Pollutants; D010636:Phenols; D010795:Phthalic Acids; D012643:Selenium; D013482:Superoxide Dismutase; D013880:Thioredoxin-Disulfide Reductase; C032279:phthalic acid; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Antioxidant system; Autism; Bisphenol A; Endocrine disruptors; Phthalate