title: Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction.
abstract: No-flow ischemia occurs during cardiac arrest, hemorrhagic shock, liver resection and transplantation. Recovery of blood flow and normal physiological pH, however, irreversibly injures the liver and other tissues. Although the liver has the powerful machinery for mitochondrial quality control, a process called mitophagy, mitochondrial dysfunction and subsequent cell death occur after reperfusion. Growing evidence indicates that reperfusion impairs mitophagy, leading to mitochondrial dysfunction, defective oxidative phosphorylation, accumulation of toxic metabolites, energy loss and ultimately cell death. The importance of acetylation/deacetylation cycle in the mitochondria and mitophagy has recently gained attention. Emerging data suggest that sirtuins, enzymes deacetylating a variety of target proteins in cellular metabolism, survival and longevity, may also act as an autophagy modulator. This review highlights recent advances of our understanding of a mechanistic correlation between sirtuin 1, mitophagy and ischemic liver injury.
authors.affiliation: Department of Surgery, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Sung Kook
authors.initials: SK
authors.lastname: Chun
authors.affiliation: Department of Surgery, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Go
authors.affiliation: Department of Surgery, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Ming-Jim
authors.initials: MJ
authors.lastname: Yang
authors.affiliation: Department of Surgery, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Zendejas
authors.affiliation: Department of Surgery, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Behrns
authors.affiliation: Department of Surgery, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Kim
keywords: Acetylation; Autophagy; Ischemia/Reperfusion; Liver; Mitochondria