title: Effect of IGF-I and TNF-α on intensification of steroid pathways in women with PCOS phenotypes are not identical. Enhancement of progesterone pathway in women with PCOS increases the concentration of TNF-α.
abstract: OBJECTIVE
  The aim of this study was to determine the correlations between the concentration of tumor necrosis factor (TNF-α) and insulin-like growth factor I (IGF-I) in each woman with polycystic ovary syndrome (PCOS) phenotypes based on the levels of androgen.
  
  
  METHODS
  Two groups of women with PCOS differing in their levels of androgens. The test group composed of 39 women with PCOS according to the Rotterdam criteria in their reproductive age. The hormonal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid stimulating hormone (TSH), prolactin (PRL), androstenedione, testosterone (T), estradiol (E2) and sex hormone binding globulin (SHBG) were measured. Correlations analysis were performed calculating Spearman's rank correlation coefficient of hormones with relation to TNF-α and IGF-I.
  
  
  RESULTS
  There was a medium positive correlation of IGF-1 with LH levels (p < 0.05) and negative medium correlation of TNF-α with of dehydroepiandrosterone (DHEA)-SO4levels (p < 0.05) only in group of PCOS women with elevated androgens.
  
  
  CONCLUSIONS
  Analysis of TNF-α showed that women with high testosterone negative correlation between level of TNF-α and the concentration of DHEA-SO4. Inflammatory state involving TNF-α in women with PCOS and high concentration of androgens is caused by intensified Δ4 (progesterone) pathway and omitted or limited Δ5 (dehydroepiandrosterone) pathway of testosterone biosynthesis.
authors.affiliation: a Department of Biochemistry and Human Nutrition , Pomeranian Medical University in Szczecin , Szczecin , Poland and.
authors.forename: M
authors.initials: M
authors.lastname: Szczuko
authors.affiliation: b Clinic of Gynecology and Urogynecology, Pomeranian Medical University in Szczecin , Szczecin , Poland.
authors.forename: M
authors.initials: M
authors.lastname: Zapałowska-Chwyć
authors.affiliation: a Department of Biochemistry and Human Nutrition , Pomeranian Medical University in Szczecin , Szczecin , Poland and.
authors.forename: A
authors.initials: A
authors.lastname: Drozd
authors.affiliation: a Department of Biochemistry and Human Nutrition , Pomeranian Medical University in Szczecin , Szczecin , Poland and.
authors.forename: D
authors.initials: D
authors.lastname: Maciejewska
authors.affiliation: b Clinic of Gynecology and Urogynecology, Pomeranian Medical University in Szczecin , Szczecin , Poland.
authors.forename: A
authors.initials: A
authors.lastname: Starczewski
authors.affiliation: a Department of Biochemistry and Human Nutrition , Pomeranian Medical University in Szczecin , Szczecin , Poland and.
authors.forename: E
authors.initials: E
authors.lastname: Stachowska
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008875:Middle Aged; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D000728:Androgens; C583557:IGF1 protein, human; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D007334:Insulin-Like Growth Factor I
keywords: Androgens; IGF-1; TNF-α; ovary; polycystic ovary syndrome