title: [The activity of blood serum cholinesterases and neprilysin as potential biomarkers of mild-cognitive impairment and Alzheimer's disease].
abstract: OBJECTIVE
  To analyze the activity of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and neprilysin (NEP) in the blood serum in elderly people with different types of cognitive impairment and evaluate the effect of ceraxon on the biochemical parameters.
  
  
  METHODS
  Three groups of patients: without cognitive disorders (controls--CG), with amnestic mild cognitive impairment (а-MCI) and with Alzheimer's disease (AD were studied).
  
  
  CONCLUSIONS
  The activity of AChE, BChE and NEP was reduced in the blood serum of patients with a-MCI and, to the greater extent, in patients with AD compared to CG and correlated with the level of cognitive dysfunction evaluated by MMSE, ADAS-cog, and other tests. For the first time, it has been shown that treatment of a-MCI patients with ceraxon (citicolin) results in an increase of the activity of blood serum AChE, BChE and NEP to the values observed in the CG. Thus, the activities of blood serum AChE, BChE and NEP reflect the level of cognitive dysfunction and can be used as prognostic biomarkers of the level of dementia progression in patients with impaired memory.
authors.affiliation: Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg; St. Petersburg State Pediatric Medical University, St. Petersburg.
authors.forename: I А
authors.initials: IА
authors.lastname: Zhuravin
authors.affiliation: Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg.
authors.forename: N N
authors.initials: NN
authors.lastname: Nalivaeva
authors.affiliation: Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg.
authors.forename: D I
authors.initials: DI
authors.lastname: Kozlova
authors.affiliation: Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg.
authors.forename: E G
authors.initials: EG
authors.lastname: Kochkina
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: Ya B
authors.initials: YB
authors.lastname: Fedorova
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: S I
authors.initials: SI
authors.lastname: Gavrilova
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood*; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D002091:Butyrylcholinesterase / Q000097:blood*; D060825:Cognitive Dysfunction / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D015260:Neprilysin / Q000097:blood*; D018697:Nootropic Agents / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D018697:Nootropic Agents; D003566:Cytidine Diphosphate Choline; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D015260:Neprilysin