title: The effect of butylphthalide on aminoacid content in the brain of epileptic mice.
abstract: BACKGROUND
  The aim of this study is to observe the effect of butylphthalide (NBP) on the amino acid content in the brain of epileptic mice.
  
  
  METHODS
  NBP was injected intraperitoneally into the mice, and acute epileptic mice models were made after 30 minutes. The change of the four amino (aspartic acid, gamma-aminobutyric acid, glutamate, glycine) content in the brain of the epileptic mice was investigated.
  
  
  RESULTS
  The contents of Glu and Glu/GABA (control group: 38.78, NBP high-dose group: 5.52) in the NBP high-dose group were lower compared with the control group. The difference was statistically significant.
  
  
  CONCLUSIONS
  NBP could regulate the balance of excitement and inhibition systems by reducing the contents of Glu and Glu/GABA, which might relieve seizures.
authors.affiliation: Department of Pharmacy, Xuzhou Children's Hospital, Xuzhou, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Pharmacy, Xuzhou Children's Hospital, Xuzhou, China.
authors.forename: Qingyang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Neurology, Xuzhou Children's Hospital, Xuzhou, China - minglx@yeah.net.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Liu
mesh_terms: D051379:Mice; D000818:Animals; D000596:Amino Acids / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D001572:Benzofurans / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism; D004827:Epilepsy / Q000188:drug therapy; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology / Q000378:metabolism
chemical_list: D000596:Amino Acids; C027125:3-n-butylphthalide; D001572:Benzofurans; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid