title: Harnessing the Versatility of Continuous-Flow Processes: Selective and Efficient Reactions.
abstract: There is a great need for effective transformations and a broad range of novel chemical entities. Continuous-flow (CF) approaches are of considerable current interest: highly efficient and selective reactions can be performed in CF reactors. The reaction setup of CF reactors offers a wide variety of possible points where versatility can be introduced. This article presents a number of selective and highly efficient gas-liquid-solid and liquid-solid reactions involving a range of reagents and immobilized catalysts. Enantioselective transformations through catalytic hydrogenation and organocatalytic reactions are included, and isotopically labelled compounds and pharmaceutically relevant 1,2,3-triazoles are synthesized in CF reactors. Importantly, the catalyst bed can be changed to a solid-phase peptide synthesis resin, with which peptide synthesis can be performed with the utilization of only 1.5 equivalents of the amino acid.
authors.affiliation: Institute of Pharmaceutical Chemistry University of Szeged, H-6720, Szeged, Eötvös u. 6, Hungary.
authors.forename: István M
authors.initials: IM
authors.lastname: Mándity
authors.affiliation: Institute of Pharmaceutical Chemistry University of Szeged, H-6720, Szeged, Eötvös u. 6, Hungary.|MTA-SZTE Stereochemistry Research Group Hungarian Academy of Sciences, H-6720, Szeged, Eötvös u. 6, Hungary.
authors.forename: Sándor B
authors.initials: SB
authors.lastname: Ötvös
authors.affiliation: MTA-SZTE Stereochemistry Research Group Hungarian Academy of Sciences, H-6720, Szeged, Eötvös u. 6, Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Szőlősi
authors.affiliation: Institute of Pharmaceutical Chemistry University of Szeged, H-6720, Szeged, Eötvös u. 6, Hungary.|MTA-SZTE Stereochemistry Research Group Hungarian Academy of Sciences, H-6720, Szeged, Eötvös u. 6, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Fülöp
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D006865:Hydrogenation; D060327:Solid-Phase Synthesis Techniques; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D006571:Heterocyclic Compounds; D014230:Triazoles
keywords: catalysis; continuous-flow; reactors; selectivity; versatility