title: Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design.
abstract: BACKGROUND
  Previous studies have reported that xylose selectively inhibited the activity of sucrase. Xylose supplementation may have a beneficial effect on the postprandial glycemic response. However, no studies have investigated patients with IFG or the effectivity of a dose of D-xylose less than 10 % (w/w).
  
  
  METHODS
  The present study determined the effect of xylose consumption on postprandial hyperglycemia in normal (n = 25) and hyperglycemic subjects (n = 50). Subjects in this double-blind crossover design study were randomly assigned to consume a sucrose drink (Control, sucrose 50 g + deionized water 100 g) or a sucrose drink additionally containing 5 g (Test 1, sucrose:xylose = 10:1), 3.33 g (Test 2, sucrose:xylose = 15:1), or 2.5 g (Test 3, sucrose:xylose = 20:1) of D-xylose separated by a one-week interval.
  
  
  RESULTS
  Normal subjects in all test groups exhibited a significant decrease in serum glucose levels 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. Significantly lower serum levels of insulin were observed at 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. The test 1 group also exhibited a significantly lower insulin area under the curve than the control group. Hyperglycemic subjects (n = 50) in all test groups exhibited a significant decrease in serum glucose levels at 30 min compared to the control group. However, the test 1 group exhibited a significant increase in serum glucose levels at 120 min compared to the control group. Glucose-related markers did not significantly differ in each group.
  
  
  CONCLUSIONS
  Xylose supplementation may exert a beneficial effect on postprandial glycemic responses in subjects with normal glucose levels and prediabetes.
  
  
  BACKGROUND
  ClinicalTrials.gov identifier: NCT02654301 . Registered 12 January 2016.
authors.affiliation: Department of Food and Nutrition, National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, Yonsei University, Sudamun-Gu, Seoul, Republic of Korea.
authors.forename: Yun Ju
authors.initials: YJ
authors.lastname: Jun
authors.affiliation: Department of Food Science and Biotechnology, CHA University, Pocheon-si, Gyeonggi-do, Republic of Korea.
authors.forename: Jinhee
authors.initials: J
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Chung-Ang University, Dongjak-gu, Seoul, Republic of Korea.
authors.forename: Sehee
authors.initials: S
authors.lastname: Hwang
authors.affiliation: Department of Preventive Medicine, Gachon University College of Medicine, Yeonsu-gu, Incheon, Republic of Korea.
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Kwak
authors.affiliation: Department of Food and Nutrition, National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, Yonsei University, Sudamun-Gu, Seoul, Republic of Korea.|Department of Food and Nutrition, Research Institute of Science for Aging, Yonsei University, Seodaemun-gu, Seoul, Republic of Korea.
authors.forename: Hyeon Yeong
authors.initials: HY
authors.lastname: Ahn
authors.affiliation: Food Ingredients R&D Center, CJ Cheiljedang Co., Suwon-si, Gyeonggi-do, Republic of Korea.
authors.forename: Youn Kyung
authors.initials: YK
authors.lastname: Bak
authors.affiliation: Food Ingredients R&D Center, CJ Cheiljedang Co., Suwon-si, Gyeonggi-do, Republic of Korea.
authors.forename: Jihoon
authors.initials: J
authors.lastname: Koh
authors.affiliation: Department of Food and Nutrition, National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, Yonsei University, Sudamun-Gu, Seoul, Republic of Korea. jhleeb@yonsei.ac.kr.|Department of Food and Nutrition, Research Institute of Science for Aging, Yonsei University, Seodaemun-gu, Seoul, Republic of Korea. jhleeb@yonsei.ac.kr.
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001628:Beverages; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D056910:Republic of Korea; D013997:Time Factors; D016896:Treatment Outcome; D014994:Xylose / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D014994:Xylose
keywords: Glucose; Postprandial hyperglycemia; Prediabetes; Xylose