title: Serum Galectin and Renal Dysfunction in ST-Segment Elevation Myocardial Infarction.
abstract: This study aimed to evaluate the association between serum galectin levels and renal dysfunction in relation to in-hospital prognosis and unfavorable prognosis 1 year after ST-elevated myocardial infarction (STEMI). Patients were assigned to two groups according to the cystatin C-based estimate of GFR on day 12 after STEMI: (1) STEMI patients with normal renal function (GFR based on cystatin C levels = 60 mL/min/1.73 m(2)) and (2) those with renal dysfunction (RD) (GFR based on cystatin C levels <60 mL/min/1.73 m(2)). A decrease in GFR estimated from the CKD-EPI equation on day 12 was more frequently found in patients with a reduced GFR based on cystatin C levels (41.9%) compared with those without RD (21.3%). Galectin levels exceeded the cut-off value (17.8 ng/mL) in 50.6% of cases in the group with GFR <60 mL/min/1.73 m(2) and in 32% of cases in the group with a normal GFR. The presence of RD and elevated galectin levels >17.8 ng/mL on day 12 after MI are independent predictors of an adverse prognosis at 1 year in STEMI patients. Elevated galectin levels are directly correlated with the presence of early postinfarction angina.
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", 6 Sosnovy Boulevard, Kemerovo 650002, Russia; Federal State Budget Educational Institution of Higher Professional Education "Kemerovo State Medical Academy of the Ministry of Health of the Russian Federation", 22a Voroshilov Street, Kemerovo 650029, Russia.
authors.forename: Victoria
authors.initials: V
authors.lastname: Karetnikova
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", 6 Sosnovy Boulevard, Kemerovo 650002, Russia; Federal State Budget Educational Institution of Higher Professional Education "Kemerovo State Medical Academy of the Ministry of Health of the Russian Federation", 22a Voroshilov Street, Kemerovo 650029, Russia.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Osokina
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", 6 Sosnovy Boulevard, Kemerovo 650002, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Gruzdeva
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", 6 Sosnovy Boulevard, Kemerovo 650002, Russia.
authors.forename: Evgenya
authors.initials: E
authors.lastname: Uchasova
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", 6 Sosnovy Boulevard, Kemerovo 650002, Russia.
authors.forename: Michael
authors.initials: M
authors.lastname: Zykov
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", 6 Sosnovy Boulevard, Kemerovo 650002, Russia.
authors.forename: Victoria
authors.initials: V
authors.lastname: Kalaeva
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", 6 Sosnovy Boulevard, Kemerovo 650002, Russia; Federal State Budget Educational Institution of Higher Professional Education "Kemerovo State Medical Academy of the Ministry of Health of the Russian Federation", 22a Voroshilov Street, Kemerovo 650029, Russia.
authors.forename: Vasily
authors.initials: V
authors.lastname: Kashtalap
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", 6 Sosnovy Boulevard, Kemerovo 650002, Russia.
authors.forename: Kristina
authors.initials: K
authors.lastname: Shafranskaya
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", 6 Sosnovy Boulevard, Kemerovo 650002, Russia.
authors.forename: Oksana
authors.initials: O
authors.lastname: Hryachkova
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", 6 Sosnovy Boulevard, Kemerovo 650002, Russia; Federal State Budget Educational Institution of Higher Professional Education "Kemerovo State Medical Academy of the Ministry of Health of the Russian Federation", 22a Voroshilov Street, Kemerovo 650029, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Barbarash
mesh_terms: D000368:Aged; D055316:Cystatin C / Q000097:blood*; D005260:Female; D037161:Galectins / Q000097:blood*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000175:diagnosis* / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D011379:Prognosis
chemical_list: C525030:CST3 protein, human; D055316:Cystatin C; D037161:Galectins