title: Arsenic-Containing Phosphatidylcholines: A New Group of Arsenolipids Discovered in Herring Caviar.
abstract: A new group of arsenolipids based on cell-membrane phosphatidylcholines has been discovered in herring caviar (fish roe). A combination of HPLC with elemental and molecular mass spectrometry was used to identify five arsenic-containing phosphatidylcholines; the same technique applied to salmon caviar identified an arsenic-containing phosphatidylethanolamine. The arsenic group in these membrane lipids might impart particular properties to the molecules not displayed by their non-arsenic analogues. Additionally, the new compounds have human health implications according to recent results showing high cytotoxicity for some arsenolipids.
authors.affiliation: Institute of Chemistry: Analytical Chemistry, NAWI Graz, University of Graz, Universitätsplatz 1, 8010, Graz, Austria.
authors.forename: Sandra A
authors.identifier: http://orcid.org/0000-0002-2013-7077
authors.initials: SA
authors.lastname: Viczek
authors.affiliation: Institute of Chemistry: Analytical Chemistry, NAWI Graz, University of Graz, Universitätsplatz 1, 8010, Graz, Austria. kenneth.jensen@uni-graz.at.
authors.forename: Kenneth B
authors.identifier: http://orcid.org/0000-0002-2481-6149
authors.initials: KB
authors.lastname: Jensen
authors.affiliation: Institute of Chemistry: Analytical Chemistry, NAWI Graz, University of Graz, Universitätsplatz 1, 8010, Graz, Austria.
authors.forename: Kevin A
authors.identifier: http://orcid.org/0000-0002-2536-0542
authors.initials: KA
authors.lastname: Francesconi
mesh_terms: D000818:Animals; D001151:Arsenic / Q000032:analysis*; D001152:Arsenicals / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D005399:Fishes / Q000378:metabolism; D005502:Food; D005504:Food Analysis; D010713:Phosphatidylcholines / Q000737:chemistry*; D012474:Salmon / Q000378:metabolism
chemical_list: D001152:Arsenicals; D010713:Phosphatidylcholines; D001151:Arsenic
keywords: arsenic; arsenolipids; phosphatidylcholines; phospholipids