title: Cancer in Drosophila: Imaginal Discs as a Model for Epithelial Tumor Formation.
abstract: Cancer genomics has greatly increased our understanding of the complexity of the genetic and epigenetic changes found in human tumors. Understanding the functional relationships among these elements calls for the use of flexible genetic models. We discuss the use of Drosophila models to study cooperation among genetic factors that contribute to disease progression.
authors.affiliation: Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Héctor
authors.initials: H
authors.lastname: Herranz
authors.affiliation: Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Teresa
authors.initials: T
authors.lastname: Eichenlaub
authors.affiliation: Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address: scohen@sund.ku.dk.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Cohen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004330:Drosophila / Q000235:genetics*; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D060227:Imaginal Discs / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology*; D009857:Oncogenes
keywords: Cancer; Disease model; Drosophila; EGFR; Epithelial–mesenchymal transition; Imaginal disc; Metastasis