title: Association of mean platelet volume and platelet count with the development and prognosis of ischemic and hemorrhagic stroke.
abstract: BACKGROUND
  Mean platelet volume (MPV) and platelet (PLT) count are the two major parameters that reflect the functions and activities of PLTs. The associations of MPV and PLT count with the occurrence and prognosis of stroke have not been fully clarified. This study aimed to investigate the association of MPV and PLT count with the development and prognosis of first-ever ischemic and hemorrhagic stroke in order to provide evidence for early diagnosis and treatment of both strokes.
  
  
  METHODS
  This study included 281 first-ever ischemic stroke and 164 first-ever hemorrhagic stroke patients between 2010 and 2012. All participants received routine blood tests within 2 h after admission and were categorized into good or poor prognosis group based on the Modified Rankin Scale (mRS) score. MPV and PLT counts were transformed into categorical variables and their association with the occurrence and prognosis of both strokes was evaluated by multivariate logistic regression.
  
  
  RESULTS
  The risk of ischemic and hemorrhagic stroke in MPV group (>13 fL) was 22.17 and 5.21 times higher compared with normal MPV group. The PLT count was positively correlated with the risk of ischemic stroke, but negatively correlated with the risk of hemorrhagic stroke. MPV and PLT count was not correlated with the prognosis of either stroke.
  
  
  CONCLUSIONS
  Increased MPV is an independent risk factor for both strokes. Elevated PLT count increases the risk for ischemic stroke, but decreases the risk for hemorrhagic stroke. However, neither MPV nor PLT count has significant association with the prognosis of either stroke.
authors.affiliation: Department of Neurology, The Nuclear Industry 416 Hospital, Chengdu, Sichuan, China.|Department of Health and Social Behavior, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China.
authors.forename: J
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Neurology, The Nuclear Industry 416 Hospital, Chengdu, Sichuan, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Health and Social Behavior, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China.
authors.forename: B
authors.initials: B
authors.lastname: He
authors.affiliation: Department of Health and Social Behavior, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China.
authors.forename: P
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Health and Social Behavior, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Chen
authors.affiliation: Department of Neurology, The Nuclear Industry 416 Hospital, Chengdu, Sichuan, China.
authors.forename: H
authors.initials: H
authors.lastname: Quan
authors.affiliation: Department of Neurology, The Nuclear Industry 416 Hospital, Chengdu, Sichuan, China.
authors.forename: X
authors.initials: X
authors.lastname: Ma
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000097:blood / Q000175:diagnosis; D002543:Cerebral Hemorrhage / Q000097:blood / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010976:Platelet Count; D011379:Prognosis; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000175:diagnosis
keywords: Ischemic stroke; hemorrhagic stroke; mean platelet volume; platelet count; prognosis