title: Increased oxidative stress in patients with severe disability: Association with nutrition.
abstract: BACKGROUND
  Previous studies have described a role of oxidative stress in the pathogenesis of various pediatric disorders, but investigation into oxidative stress status in patients with severe disability remains limited. The aim of the present study was therefore to clarify the oxidative stress status in patients with severe disability, focusing specifically on intake of three major nutrients and micronutrients with antioxidant activities.
  
  
  METHODS
  Thirty-one patients with severe disability (mean age, 14.1 ± 7.8 years) were enrolled. Three in vivo biomarkers, plasma biological antioxidant potential (BAP), plasma reactive oxygen metabolite-derived compounds (d-ROM), and urinary 8-hydroxydeoxyguanosine (8-OHdG), were determined for evaluating oxidative status. The dietary intake of three major nutrients and various micronutrients was estimated from dietary records over a 3 day period.
  
  
  RESULTS
  In patients with severe disability, BAP was significantly lower and d-ROM and 8-OHdG significantly higher than in historical controls. Among these markers, a significant positive correlation was found in BAP versus d-ROM and d-ROM versus 8-OHdG. On multiple regression analysis, a significant inverse association between 8-OHdG and carotenoid intake was seen.
  
  
  CONCLUSIONS
  The oxidative/antioxidative balance shifts towards oxidative status dominance in patients with severe disability. More research is needed on nutritional intake of antioxidative nutrients to determine whether they can be used to reduce oxidative stress.
authors.affiliation: Department of Pediatrics, Todaiji Medical and Education Center, Nara, Japan.
authors.forename: Chiharu
authors.initials: C
authors.lastname: Kawaguchi
authors.affiliation: Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.
authors.forename: Marie
authors.initials: M
authors.lastname: Morinaga
authors.affiliation: Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.|Faculty of Agriculture, Ryukoku University, Kyoto, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Kubota
authors.affiliation: Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Saito
authors.affiliation: Department of Pediatrics, Todaiji Medical and Education Center, Nara, Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Tomiwa
authors.affiliation: Health Management Center, Nara Medical University, Nara, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Uchiike
mesh_terms: D000293:Adolescent; D000975:Antioxidants; D015415:Biomarkers / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009752:Nutritional Status; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D017382:Reactive Oxygen Species
keywords: 8-hydroxydeoxyguanosine; biological antioxidant potential; disabled patient; micronutrient; oxidative stress