title: Ferrocene-Modified Phospholipid: An Innovative Precursor for Redox-Triggered Drug Delivery Vesicles Selective to Cancer Cells.
abstract: Controlled payload release is one of the key elements in the creation of a reliable drug delivery system. We report the discovery of a drug delivery vessel able to transport chemotherapeutic agents to target cancer cells and selectively trigger their release using the electrochemical activity of a ferrocene-modified phospholipid. Supported by in vitro assays, the competitive advantages of this discovery are (i) the simple one step scalability of the synthetic process, (ii) the stable encapsulation of toxic drugs (doxorubicin) during transport, and (iii) the selective redox triggering of the liposomes to harness their cytotoxic payload at the cancer site. Specifically, the redox-modified giant unilamellar vesicle and liposomes were characterized using advanced methods such as scanning electrochemical microscopy (SECM), transmission electron microscopy (TEM), dynamic light scattering (DLS), and fluorescent imaging.
authors.affiliation: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A OB8.
authors.forename: Tomer
authors.initials: T
authors.lastname: Noyhouzer
authors.affiliation: Laboratoire de Méthodologie et Synthèse de Produits Naturels, Université du Québec à Montréal , C.P. 8888, Succ. Centre-Ville, Montréal, H3C 3P8, Québec, Canada.
authors.forename: Chloé
authors.initials: C
authors.lastname: L'Homme
authors.affiliation: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A OB8.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Beaulieu
authors.affiliation: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A OB8.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Mazurkiewicz
authors.affiliation: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A OB8.
authors.forename: Sabine
authors.initials: S
authors.lastname: Kuss
authors.affiliation: Department of Physical and Environmental Sciences, University of Toronto Scarborough , Toronto, Ontario M1C 1A4, Canada.
authors.forename: Heinz-Bernhard
authors.initials: HB
authors.lastname: Kraatz
authors.affiliation: Laboratoire de Méthodologie et Synthèse de Produits Naturels, Université du Québec à Montréal , C.P. 8888, Succ. Centre-Ville, Montréal, H3C 3P8, Québec, Canada.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Canesi
authors.affiliation: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A OB8.
authors.forename: Janine
authors.initials: J
authors.lastname: Mauzeroll
mesh_terms: D004317:Doxorubicin / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005296:Ferrous Compounds / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D000075163:Metallocenes / Q000737:chemistry*; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D005296:Ferrous Compounds; D000075163:Metallocenes; D010743:Phospholipids; D004317:Doxorubicin; C004998:ferrocene