title: Monocyte cell membrane-derived nanoghosts for targeted cancer therapy.
abstract: Core-shell type 'nanoghosts' were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.
authors.affiliation: School of Chemical and Biomedical Engineering and Lee Kong Chian School of Medicine, Nanyang Technological University, Block N1.3, #B4-10, 70 Nanyang Drive, Singapore 637457. julianachan@ntu.edu.sg.
authors.forename: S
authors.initials: S
authors.lastname: Krishnamurthy
authors.affiliation: Department of Biomedical Engineering, National University of Singapore, 9 Engineering Drive 1, Block EA, #03-12, Singapore 117575.
authors.forename: M K
authors.initials: MK
authors.lastname: Gnanasammandhan
authors.affiliation: School of Chemical and Biomedical Engineering and Lee Kong Chian School of Medicine, Nanyang Technological University, Block N1.3, #B4-10, 70 Nanyang Drive, Singapore 637457. julianachan@ntu.edu.sg.
authors.forename: C
authors.initials: C
authors.lastname: Xie
authors.affiliation: Department of Biomedical Engineering, National University of Singapore, 9 Engineering Drive 1, Block EA, #03-12, Singapore 117575.
authors.forename: K
authors.initials: K
authors.lastname: Huang
authors.affiliation: School of Chemical and Biomedical Engineering and Lee Kong Chian School of Medicine, Nanyang Technological University, Block N1.3, #B4-10, 70 Nanyang Drive, Singapore 637457. julianachan@ntu.edu.sg.
authors.forename: M Y
authors.initials: MY
authors.lastname: Cui
authors.affiliation: School of Chemical and Biomedical Engineering and Lee Kong Chian School of Medicine, Nanyang Technological University, Block N1.3, #B4-10, 70 Nanyang Drive, Singapore 637457. julianachan@ntu.edu.sg.
authors.forename: J M
authors.initials: JM
authors.lastname: Chan
mesh_terms: D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D002470:Cell Survival / Q000187:drug effects; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D061986:MCF-7 Cells; D009000:Monocytes / Q000648:ultrastructure*; D053758:Nanoparticles; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004317:Doxorubicin