title: Partitioned log-rank tests for the overall homogeneity of hazard rate functions.
abstract: In survival analysis, it is routine to test equality of two survival curves, which is often conducted by using the log-rank test. Although it is optimal under the proportional hazards assumption, the log-rank test is known to have little power when the survival or hazard functions cross. To test the overall homogeneity of hazard rate functions, we propose a group of partitioned log-rank tests. By partitioning the time axis and taking the supremum of the sum of two partitioned log-rank statistics over different partitioning points, the proposed test gains enormous power for cases with crossing hazards. On the other hand, when the hazards are indeed proportional, our test still maintains high power close to that of the optimal log-rank test. Extensive simulation studies are conducted to compare the proposed test with existing methods, and three real data examples are used to illustrate the commonality of crossing hazards and the advantages of the partitioned log-rank tests.
authors.affiliation: Department of Statistics and Actuarial Science, School of Statistics, East China Normal University, Shanghai, China.
authors.forename: Yukun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Statistics and Actuarial Science, The University of Hong Kong, Pokfulam Road, Hong Kong, China. gyin@hku.hk.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Yin
mesh_terms: D001699:Biometry; D006801:Humans; D016016:Proportional Hazards Models; D016019:Survival Analysis
keywords: Censored data; Hazard function; Log rank test; Survival difference; Survival function; Weighted tests