title: Depression and anxiety symptoms in Spanish adult patients with cystic fibrosis: associations with health-related quality of life.
abstract: Cystic fibrosis (CF) is a chronic disease with an impact on the quality of life. Self-reported symptoms of depression and anxiety were assessed in the Spanish cohort of the International Epidemiological Study on Depression and Anxiety in patients with CF (International Depression-Anxiety Epidemiological Study) and their relationship with health status and health-related quality of life (HRQoL) was evaluated.
  
  
  
  This cross-sectional study recruited adult patients with CF at 10 Spanish centers. Patients completed the Hospital Anxiety and Depression Scale (HADS) and the Revised Cystic Fibrosis Questionnaire. Demographic and health data were recorded from medical charts. Logistic regression was used to determine the predictors of elevated symptoms of depression and anxiety (HADS≥8).
  
  
  
  Of the 336 participants recruited (mean age, 28.1years; 48.2% women), 41 (12.2%) had elevated depression-related scores, and 100 (29.7%) had elevated anxiety-related scores (HADS≥8). After adjusting for confounders, only less education, intravenous antibiotics, psychiatric medications and psychotherapy were significantly associated with elevated psychological symptoms. Specifically, regardless of lung function, patients who were depressed or anxious reported worse HRQoL.
  
  
  
  The prevalence of elevated symptoms of depression and anxiety was high in Spanish adult patients with CF, and these symptoms were associated with a decreased HRQoL.
authors.affiliation: Pneumology, Malaga Regional University Hospital, Instituto de Biomedicina de Málaga (IBIMA), Málaga University, Spain. Electronic address: casi1547@separ.es.
authors.forename: C
authors.initials: C
authors.lastname: Olveira
authors.affiliation: Lung Transplant and Cystic Fibrosis Unit, University and Politecnic Hospital la Fe, Valencia, Spain. Electronic address: sole_amp@gva.es.
authors.forename: A
authors.initials: A
authors.lastname: Sole
authors.affiliation: Pneumology Department, La Princesa Institute for Health Research, La Princesa University Hospital, Madrid, Spain. Electronic address: rmgiron@gmail.com.
authors.forename: R M
authors.initials: RM
authors.lastname: Girón
authors.affiliation: Cystic Fibrosis Unit Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocio/Sevilla University, Sevilla, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: esther.quintana@telefonica.net.
authors.forename: E
authors.initials: E
authors.lastname: Quintana-Gallego
authors.affiliation: Pediatric Pneumology and Cystic Fibrosis Unit, University Hospital Virgen de la Arrixaca, Murcia, Spain. Electronic address: pmondejarlopez@yahoo.es.
authors.forename: P
authors.initials: P
authors.lastname: Mondejar
authors.affiliation: Pneumology, Cystic Fibrosis Unit, Hospital de Cruces, Vizcaya, Spain. Electronic address: felixmaria.barandagarcia@osakidetza.net.
authors.forename: F
authors.initials: F
authors.lastname: Baranda
authors.affiliation: Adult Cystic Fibrosis Unit, Pneumology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Electronic address: aalvarez@vhebron.net.
authors.forename: A
authors.initials: A
authors.lastname: Alvarez
authors.affiliation: Cystic Fibrosis Unit, Pneumology, University Hospital La Paz, Madrid, Spain. Electronic address: conchaprados@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Prados
authors.affiliation: Pneumology, Hospital Ntra, Sra de Candelaria, Santa Cruz de Tenerife, Spain. Electronic address: jesusrgtej@terra.es.
authors.forename: J
authors.initials: J
authors.lastname: Rodríguez-González
authors.affiliation: Pneumology, Hospital Miguel Servet, Zaragoza, Spain. Electronic address: miherrerol@salud.aragon.es.
authors.forename: I
authors.initials: I
authors.lastname: Herrero-Labarga
authors.affiliation: Department of Psychology, Pediatrics, University of Miami, USA. Electronic address: aquittner@miami.edu.
authors.forename: A
authors.initials: A
authors.lastname: Quittner
authors.affiliation: Endocrinology and Nutrition, Malaga Regional University Hospital, Instituto de Biomedicina de Málaga (IBIMA), Málaga University, Spain; CIBERDEM, CIBER of Diabetes and Associated Metabolic Diseases (Instituto de Salud Carlos III: CB07/08/0019). Electronic address: gabrielm.olveira.sspa@juntadeandalucia.es.
authors.forename: G
authors.initials: G
authors.lastname: Olveira
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000175:diagnosis* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000453:epidemiology / Q000523:psychology*; D003863:Depression / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D011788:Quality of Life; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
keywords: Anxiety; Cystic fibrosis; Depression; Lung function; Quality of life