title: The Contradictory Effects of Neuronal Hyperexcitation on Adult Hippocampal Neurogenesis.
abstract: Adult hippocampal neurogenesis is a highly plastic process that responds swiftly to neuronal activity. Adult hippocampal neurogenesis can be regulated at the level of neural stem cell recruitment and activation, progenitor proliferation, as well as newborn cell survival and differentiation. An "excitation-neurogenesis" rule was proposed after the demonstration of the capability of cultured neural stem and progenitor cells to intrinsically sense neuronal excitatory activity. In vivo, this property has remained elusive although recently the direct response of neural stem cells to GABA in the hippocampus via GABAA receptors has evidenced a mechanism for a direct talk between neurons and neural stem cells. As it is pro-neurogenic, the effect of excitatory neuronal activity has been generally considered beneficial. But what happens in situations of neuronal hyperactivity in which neurogenesis can be dramatically boosted? In animal models, electroconvulsive shock markedly increases neurogenesis. On the contrary, in epilepsy rodent models, seizures induce the generation of misplaced neurons with abnormal morphological and electrophysiological properties, namely aberrant neurogenesis. We will herein discuss what is known about the mechanisms of influence of neurons on neural stem cells, as well as the severe effects of neuronal hyperexcitation on hippocampal neurogenesis.
authors.affiliation: Laboratory of Neural Stem Cells and Neurogenesis, Achucarro Basque Center for Neuroscience Zamudio, Spain.
authors.forename: José R
authors.initials: JR
authors.lastname: Pineda
authors.affiliation: Laboratory of Neural Stem Cells and Neurogenesis, Achucarro Basque Center for NeuroscienceZamudio, Spain; IKERBASQUE, The Basque Foundation for ScienceBilbao, Spain.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Encinas
keywords: epilepsy; hippocampus; hyperexcitation; neural stem cells; neurogenesis