title: Bipolaris oryzae, a novel fungal opportunist causing keratitis.
abstract: We report a case of mycotic keratitis caused by Bipolaris oryzae with predisposing trauma from a foreign body. The fungus was identified by sequencing the internal transcribed spacer region, translation elongation factor 1α (TEF1) gene, and partial glyceraldehyde-3-phosphate dehydrogenase (GPDH) gene, and the species identity was confirmed on the basis of its characteristic conidial phenotype. The patient was treated with surgical intervention and antifungal agents, including intravenous fluconazole (FLC), oral itraconazole, topical 0.15% amphotericin B eye drops, and 0.5% FLC eye drops. To our knowledge, this is the first report of mycotic keratitis caused by B. oryzae worldwide.
authors.affiliation: Laboratory Department, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Luxia
authors.initials: L
authors.lastname: Wang
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands; Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands; Directorate General of Health Services, Ministry of Health, Ibri Hospital, Ibri, Oman.
authors.forename: Abdullah M S
authors.initials: AM
authors.lastname: Al-Hatmi
authors.affiliation: Department of Pathology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Xuwen
authors.initials: X
authors.lastname: Lai
authors.affiliation: Department of Ophthalmology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Lianghong
authors.initials: L
authors.lastname: Peng
authors.affiliation: Department of Ophthalmology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Chuanhong
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Ophthalmology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Huangwen
authors.initials: H
authors.lastname: Lai
authors.affiliation: Laboratory Department, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Jianxun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Jacques F
authors.initials: JF
authors.lastname: Meis
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands; Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands; Basic Pathology Department, Federal University of Paraná State, Curitiba, Paraná, Brazil; King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: G Sybren
authors.initials: GS
authors.lastname: de Hoog
authors.affiliation: State Key Laboratory of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. Electronic address: chao_sheep@263.net.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhuo
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands; Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands; Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Medical Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address: chenmin9611233@163.com.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001203:Ascomycota / Q000145:classification / Q000166:cytology / Q000235:genetics / Q000648:ultrastructure; D005800:Genes, Fungal; D006801:Humans; D007634:Keratitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D010802:Phylogeny; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009883:Ophthalmic Solutions; D000666:Amphotericin B
keywords: Amphotericin B; Bipolaris oryzae; Mycotic keratitis