title: The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models.
abstract: Fetal Alcohol Spectrum Disorders (FASD) are characterized by deficits in working memory, response inhibition, and behavioral flexibility. However, the combination and severity of impairments are highly dependent upon maternal ethanol consumption patterns, which creates a complex variety of manifestations. Rodent models have been essential in identifying behavioral endpoints of prenatal alcohol exposure (PAE). However, experimental model outcomes are extremely diverse based on level, pattern, timing, and method of ethanol exposure, as well as the behavioral domain assayed and paradigm used. Therefore, comparisons across studies are difficult and there is currently no clear comprehensive behavioral phenotype of PAE. This lack of defined cognitive and behavioral phenotype is a contributing factor to the difficulty in identifying FASD individuals. The current review aims to critically examine preclinical behavioral outcomes in the social, cognitive, and affective domains in terms of the PAE paradigm, with a special emphasis on dose, timing, and delivery, to establish a working model of behavioral impairment. In addition, this review identifies gaps in our current knowledge and proposes future areas of research that will advance knowledge in the field of PAE outcomes. Understanding the complex behavioral phenotype, which results from diverse ethanol consumption will allow for development of better diagnostic tools and more critical evaluation of potential treatments for FASD.
authors.affiliation: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA.
authors.forename: Kristin
authors.initials: K
authors.lastname: Marquardt
authors.affiliation: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA; New Mexico Alcohol Research Center, UNM Health Sciences Center, Albuquerque, NM, USA. Electronic address: jbrigman@salud.unm.edu.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Brigman
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects* / Q000523:psychology; D000818:Animals; D003072:Cognition Disorders / Q000139:chemically induced / Q000473:pathology* / Q000523:psychology; D004195:Disease Models, Animal; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000209:etiology / Q000473:pathology* / Q000523:psychology; D006801:Humans; D051379:Mice; D019964:Mood Disorders / Q000139:chemically induced / Q000473:pathology / Q000523:psychology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000473:pathology* / Q000523:psychology; D051381:Rats; D012919:Social Behavior
keywords: Anxiety and motor learning; Executive function; Preclinical models; Social behavior; Spatial and temporal memory