title: Serum D-dimer as an indicator of immediate mortality in patients with in-hospital cardiac arrest.
abstract: BACKGROUND
  Blood coagulation and fibrin activation with impaired fibrinolysis occurs not only during cardiac arrest (CA) but also after the return of spontaneous circulation (ROSC). The aim of the present study was to investigate the prognostic marker of immediate mortality prediction in in-hospital cardiac arrest (IHCA), with special attention to the serum D-dimer concentration.
  
  
  METHODS
  Retrospective chart review. Adult patients subjected to IHCA with resuscitation in the medical intensive care unit (ICU) from January 2012 to July 2015 were enrolled. Information about patient baseline characteristics, resuscitation characteristics, biochemical parameters and outcome details were collected. Logistic regression analysis was calculated to identify independent predictors for mortality. Receiver operating characteristic (ROC) curves were utilized to evaluate the accuracy of predictors.
  
  
  RESULTS
  Of the studied 192 patients (115 men, mean age 64.98±17.66years), more than half-part patients died immediately after resuscitation (118/192, 61.46%). The patients who failed to resuscitate had more often had a history of septicemia (15.25% vs 2.7%, p=0.006), renal insufficiency (38.14% vs 14.86%, p=0.001), pneumonia (51.69% vs 33.78%, p=0.015) and less often had an initial shockable rhythm (16.1% vs 29.73%, p=0.019) than those who sustained ROSC. Pre-CA serum D-dimer concentration was significantly higher in the death group than that in ROSC group (22.48±17.66 vs 9.49±9.09mg/L, p<0.0001). On multivariate logistic regression analysis, D-dimer (odds ratios, 1.07, 95% confidence interval 1.02 to 1.13) was an independent predictor of mortality.
  
  
  CONCLUSIONS
  Serum D-dimer serves as a useful indicator of immediate mortality after resuscitation in patients with IHCA.
authors.affiliation: Department of Neurology, The Second People's Hospital of Chengdu, Chengdu, Sichuan, PR China.
authors.forename: Yushuang
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Neurology, The Second People's Hospital of Chengdu, Chengdu, Sichuan, PR China.
authors.forename: Lanying
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Neurology, The Second People's Hospital of Chengdu, Chengdu, Sichuan, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Neurology, The Second People's Hospital of Chengdu, Chengdu, Sichuan, PR China. Electronic address: jianwangx@sina.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006323:Heart Arrest / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000401:mortality; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D
keywords: D-dimer; In-hospital cardiac arrest; Mortality; Prognosis