title: The progress of angiogenic factors in the development of leukemias.
abstract: Angiogenic factors have been demonstrated to play important roles in modulating angiogenesis of solid tumors. Recently, accumulating studies extensively indicated that some angiogenic factors widely exist in malignant cells of hematologic malignancy, which regulated the expression of a number of genes that were involved in abnormal proliferation, differentiation and apoptosis of these cells. With deep research of angiogenic factors, its expression, function and regulatory mechanism were gradually elucidated, and some of them were related to the development and prognosis of leukemia, or provide more possible strategies for treatment of patients with leukemia. Herein, we summarize the progress in study of some important angiogenic factors and hematological malignancies.
authors.affiliation: Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Ji'nan, Shandong, China; School of Medicine and Life Sciences, Ji'nan University, Ji'nan, Shandong, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Han
authors.affiliation: Laboratory Department, People's Hospital of Zhangqiu City, Zhangqiu, Shandong, China.
authors.forename: Xidi
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Hematology, Shengli Oilfield Central Hospital, Dongying, China.
authors.forename: Bingping
authors.initials: B
authors.lastname: Wang
authors.affiliation: Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Jiang
keywords: Angiogenesis; angiogenic factors; leukemia