title: Comparing and Contrasting Consensus versus Empirical Domains.
abstract: BACKGROUND
  Since the publication of the CFS case definition [1], there have been a number of other criteria proposed including the Canadian Consensus Criteria [2] and the Myalgic Encephalomyelitis: International Consensus Criteria. [3].
  
  
  OBJECTIVE
  The current study compared these domains that were developed through consensus methods to one obtained through more empirical approaches using factor analysis.
  
  
  METHODS
  Using data mining, we compared and contrasted fundamental features of consensus-based criteria versus empirical latent factors. In general, these approaches found the domain of Fatigue/Post-exertional malaise as best differentiating patients from controls.
  
  
  RESULTS
  Findings indicated that the Fukuda et al. criteria had the worst sensitivity and specificity.
  
  
  CONCLUSIONS
  These outcomes might help both theorists and researchers better determine which fundamental domains to be used for the case definition.
authors.affiliation: DePaul University, Chicago, Illinois.
authors.forename: Leonard A
authors.initials: LA
authors.lastname: Jason
authors.affiliation: DePaul University, Chicago, Illinois.
authors.forename: Bobby
authors.initials: B
authors.lastname: Kot
authors.affiliation: DePaul University, Chicago, Illinois.
authors.forename: Madison
authors.initials: M
authors.lastname: Sunnquist
authors.affiliation: DePaul University, Chicago, Illinois.
authors.forename: Abigail
authors.initials: A
authors.lastname: Brown
authors.affiliation: DePaul University, Chicago, Illinois.
authors.forename: Jordan
authors.initials: J
authors.lastname: Reed
authors.affiliation: DePaul University, Chicago, Illinois.
authors.forename: Jacob
authors.initials: J
authors.lastname: Furst
authors.affiliation: Newcastle University, Newcastle, UK.
authors.forename: Julia L
authors.initials: JL
authors.lastname: Newton
authors.affiliation: Oslo University Hospital, Oslo, Norway.
authors.forename: Elin Bolle
authors.initials: EB
authors.lastname: Strand
authors.affiliation: Solve ME/CFS Initiative, Los Angles, USA.
authors.forename: Suzanne D
authors.initials: SD
authors.lastname: Vernon
keywords: Myalgic Encephalomyelitis; biomarkers; case definitions; chronic fatigue syndrome