title: Relationship Between 25(OH)D and IGF-I in Children and Adolescents with Growth Hormone Deficiency.
abstract: Recent studies have shown that vitamin D has an impact on the production and secretion of IGF-I in the liver. The aim of our study was to investigate the relationship between the concentrations of 25-hydroxy vitamin D [25(OH)D] and insulin-like growth factor I (IGF-I) in growth hormone deficient children and adolescents before recombinant human growth hormone (rhGH) treatment. The study was retrospective and included 84 children and adolescents aged 4-17. Prior to initiating rhGH therapy, concentrations of 25(OH)D and IGF-I were measured in all patients. IGF-I concentrations were normalized for bone age. The studied group was divided into two subgroups according to serum 25(OH)D levels. Significant positive correlations between 25(OH)D concentration and IGF-I SDS-normalized for bone age were observed in both studied subgroups. The results of our study suggest that vitamin D deficiency could influence IGF-I concentrations in children and adolescents with growth hormone deficiency, and vitamin D deficiency should be normalized before the measurement of IGF-I concentrations to obtain the reliable and unbiased IGF-I values.
authors.affiliation: Department of Pediatrics and Endocrinology, Warsaw Medical University, 63A Żwirki i Wigury St., 02-091, Warsaw, Poland. ewelina.witkowska-sedek@wum.edu.pl.
authors.forename: E
authors.initials: E
authors.lastname: Witkowska-Sędek
authors.affiliation: Department of Pediatrics and Endocrinology, Warsaw Medical University, 63A Żwirki i Wigury St., 02-091, Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Kucharska
authors.affiliation: Department of Pediatrics and Endocrinology, Warsaw Medical University, 63A Żwirki i Wigury St., 02-091, Warsaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Rumińska
authors.affiliation: Department of Pediatrics and Endocrinology, Warsaw Medical University, 63A Żwirki i Wigury St., 02-091, Warsaw, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Pyrżak
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D012189:Retrospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood
chemical_list: D019382:Human Growth Hormone; D014807:Vitamin D; D007334:Insulin-Like Growth Factor I; C104450:25-hydroxyvitamin D
keywords: 25(OH)D; Adolescents; Children; Growth hormone deficiency; IGF-I; rhGH treatment