title: Ursolic acid plays a protective role in obesity-induced cardiovascular diseases.
abstract: The metabolic disturbance of obesity is one of the most common risk factors of atherosclerosis. Resistin, an obesity-induced adipokine, can induce the expression of cell adhesion molecules and the attachment of monocytes to endothelial cells, which play an important role in the development of atherosclerosis. Ursolic acid, a pentacyclic triterpenoid found in fruits and many herbs, exhibits an array of biological effects such as anti-inflammatory and antioxidative properties. The aim of this study was to investigate the potential underlying mechanisms of the effect of ursolic acid on resistin-induced adhesion of U937 cells to human umbilical vein endothelial cells (HUVECs). Our data indicated that ursolic acid suppressed the adhesion of U937 to HUVECs and downregulated the expression of adhesion molecules, vascular cell adhesion molecule-1 (VCAM-1), intracellular cell adhesion molecule-1 (ICAM-1), and E-selectin, in resistin-induced HUVECs by decreasing the production of intracellular reaction oxygen species (ROS) and attenuating the nuclear translocation of NFκB. Ursolic acid appeared to inhibit resistin-induced atherosclerosis, suggesting that ursolic acid may play a protective role in obesity-induced cardiovascular diseases.
authors.affiliation: a Graduate Institute of Nutrition, China Medical University, Taichung, Taiwan.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Lin
authors.affiliation: b Department of Nutrition and Health Sciences, Chang Jung Christian University, Tainan, Taiwan.
authors.forename: Ya-Mei
authors.initials: YM
authors.lastname: Yu
authors.affiliation: c Graduate Institute of Medical Science, Chang Jung Christian University, Tainan, Taiwan.
authors.forename: Weng-Cheng
authors.initials: WC
authors.lastname: Chang
authors.affiliation: d Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan.
authors.forename: Su-Yin
authors.initials: SY
authors.lastname: Chiang
authors.affiliation: e Department of Biochemistry, China Medical University, Taichung, Taiwan.
authors.forename: Hsu-Chin
authors.initials: HC
authors.lastname: Chan
authors.affiliation: b Department of Nutrition and Health Sciences, Chang Jung Christian University, Tainan, Taiwan.
authors.forename: Ming-Fen
authors.initials: MF
authors.lastname: Lee
mesh_terms: D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D014315:Triterpenes / Q000494:pharmacology* / Q000627:therapeutic use; D020298:U937 Cells; D000097245:Ursolic Acid
chemical_list: D002316:Cardiotonic Agents; D014315:Triterpenes; D000097245:Ursolic Acid
keywords: NFκB; acide ursolique; adhesion molecule; atherosclerosis; athérosclérose; espèce réactive d’oxygène; molécule d’adhésion; obesity; obésité; reaction oxygen species; resistin; résistine; triterpenoid; triterpénoïde; ursolic acid