title: Crizotinib-induced toxicity in an experimental rat model.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an experimental rat model.
  
  
  METHODS
  Eighteen Wistar albino rats were divided into three groups: experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively.
  
  
  RESULTS
  Subjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas.
  
  
  CONCLUSIONS
  This study is the first to evaluate the histopathological features of toxicity of crizotinib in a rat model.
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Gaziosmanpasa University, 60250, Tokat, Turkey. ozgebostankolu@hotmail.com.
authors.forename: Ozge
authors.initials: O
authors.lastname: Gumusay
authors.affiliation: Department of Medical Pathology, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Guldal
authors.initials: G
authors.lastname: Esendagli-Yilmaz
authors.affiliation: Department of Internal Medicine, Division of Medical Oncology, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Aytug
authors.initials: A
authors.lastname: Uner
authors.affiliation: Department of Internal Medicine, Division of Medical Oncology, Cumhuriyet University Sivas, Sivas, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Cetin
authors.affiliation: Department of Internal Medicine, Division of Medical Oncology, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Buyukberber
authors.affiliation: Department of Internal Medicine, Division of Medical Oncology, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Benekli
authors.affiliation: Department of Public Health, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Mustafa N
authors.initials: MN
authors.lastname: Ilhan
authors.affiliation: Department of Internal Medicine, Division of Medical Oncology, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Coskun
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Gulbahar
authors.affiliation: Department of Internal Medicine, Division of Medical Oncology, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozet
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity; D000077547:Crizotinib; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D009928:Organ Specificity; D011720:Pyrazoles / Q000008:administration & dosage / Q000633:toxicity*; D011725:Pyridines / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome; D014781:Viscera / Q000187:drug effects* / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib
keywords: Crizotinib; Pulmonary intraalveolar hemorrhage; Rat; Toxicity