title: Pedal edema associated with atypical antipsychotics.
abstract: This study describes a patient diagnosed as a case of bipolar affective disorder complaining of bothersome incidence of pedal edema 1 month after the initiation of atypical antipsychotic regimen with risperidone and quetiapine. All hematological and biochemical profiles were found to be normal. On discontinuation of risperidone, the condition remained unresolved even after 2 weeks, and the edema progressed reaching her calves. On tapering the dose of quetiapine, she started showing gradual improvement in edematous condition. Quetiapine was slowly discontinued. No further recurrence of edema occurred, and hence, no further medication changes were implemented. Pedal edema was found to be resolved within weeks of dechallenge of the regimen. Naranjo adverse drug reaction probability scale gave a score of 7 which denotes "probable" adverse drug reaction with quetiapine.
authors.affiliation: Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
authors.forename: Santanu
authors.initials: S
authors.lastname: Munshi
authors.affiliation: Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
authors.forename: Shatavisa
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: Department of Psychiatry, Medical College and Hospital, Kolkata, West Bengal, India.
authors.forename: Indranil
authors.initials: I
authors.lastname: Saha
authors.affiliation: Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
authors.forename: Sukanta
authors.initials: S
authors.lastname: Sen
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D004487:Edema / Q000139:chemically induced*; D005260:Female; D005528:Foot; D006801:Humans; D000069348:Quetiapine Fumarate / Q000009:adverse effects*; D018967:Risperidone / Q000009:adverse effects*
chemical_list: D014150:Antipsychotic Agents; D000069348:Quetiapine Fumarate; D018967:Risperidone
keywords: Atypical antipsychotics; pedal edema; quetiapine; risperidone