title: Early human herpes virus type 6 reactivation in umbilical cord blood allogeneic stem cell transplantation.
abstract: Human herpes virus type 6 can reactivate in patients after allogeneic stem cell transplantation and has been associated with serious sequelae such as delayed engraftment and an increased risk of developing acute graft-versus-host disease (GVHD). This study investigated human herpes virus type 6 (HHV-6) reactivation within 60 days of transplantation in stem cell transplants utilizing single umbilical cord blood, double umbilical cord blood, or umbilical cord blood plus haploidentical stem cells. Of 92 patients, 60 (65%) had HHV-6 reactivation. Reactivation was not significantly influenced by any patient characteristics, disease characteristics, or by stem cell source (umbilical cord blood only versus haploidentical plus umbilical cord blood). We did not observe any impact of HHV-6 reactivation on neutrophil or platelet count recovery or on relapse-free survival. HHV-6 reactivation was associated with subsequent development of prerelapse acute GVHD (HR = 3.00; 95% CI, 1.4 to 6.4; p = 0.004).
authors.affiliation: a NewYork-Presbyterian Hospital , New York , NY , USA ;
authors.forename: Frank
authors.initials: F
authors.lastname: Cirrone
authors.affiliation: a NewYork-Presbyterian Hospital , New York , NY , USA ;
authors.forename: Cindy
authors.initials: C
authors.lastname: Ippoliti
authors.affiliation: a NewYork-Presbyterian Hospital , New York , NY , USA ;
authors.forename: Hanhan
authors.initials: H
authors.lastname: Wang
authors.affiliation: a NewYork-Presbyterian Hospital , New York , NY , USA ;
authors.forename: Xi Kathy
authors.initials: XK
authors.lastname: Zhou
authors.affiliation: a NewYork-Presbyterian Hospital , New York , NY , USA ;|b Weill Cornell Medical College , New York , NY , USA.
authors.forename: Usama
authors.initials: U
authors.lastname: Gergis
authors.affiliation: a NewYork-Presbyterian Hospital , New York , NY , USA ;|b Weill Cornell Medical College , New York , NY , USA.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Mayer
authors.affiliation: a NewYork-Presbyterian Hospital , New York , NY , USA ;|b Weill Cornell Medical College , New York , NY , USA.
authors.forename: Tsiporah
authors.initials: T
authors.lastname: Shore
authors.affiliation: a NewYork-Presbyterian Hospital , New York , NY , USA ;|b Weill Cornell Medical College , New York , NY , USA.
authors.forename: Koen
authors.initials: K
authors.lastname: van Besien
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D019349:Roseolovirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D016019:Survival Analysis; D014184:Transplantation, Homologous; D014775:Virus Activation / Q000276:immunology; D055815:Young Adult
keywords: Graft-versus-host disease; HHV-6 reactivation; umbilical cord blood transplant