title: Synergistic Inhibitory Effect of Peptide-Organic Coassemblies on Amyloid Aggregation.
abstract: Inhibition of amyloid aggregation is important for developing potential therapeutic strategies of amyloid-related diseases. Herein, we report that the inhibition effect of a pristine peptide motif (KLVFF) can be significantly improved by introducing a terminal regulatory moiety (terpyridine). The molecular-level observations by using scanning tunneling microscopy reveal stoichiometry-dependent polymorphism of the coassembly structures, which originates from the terminal interactions of peptide with organic modulator moieties and can be attributed to the secondary structures of peptides and conformations of the organic molecules. Furthermore, the polymorphism of the peptide-organic coassemblies is shown to be correlated to distinctively different inhibition effects on amyloid-β 42 (Aβ42) aggregations and cytotoxicity.
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Niu
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.|Institute for Advanced Materials, Jiangsu University , Jiangsu 212013, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences (MOE), and Department of Physics, Fudan University , Shanghai 200433, China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Xi
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Qiusen
authors.initials: Q
authors.lastname: Han
authors.affiliation: Interdisciplinary Nanoscience Center (iNANO), Center for DNA Nanotechnology (CDNA), Aarhus University , DK-8000 Aarhus C, Denmark.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yu
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Qunxing
authors.initials: Q
authors.lastname: Huang
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Fuyang
authors.initials: F
authors.lastname: Qu
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Xu
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Yibao
authors.initials: Y
authors.lastname: Li
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Huiwen
authors.initials: H
authors.lastname: Du
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.affiliation: Interdisciplinary Nanoscience Center (iNANO), Center for DNA Nanotechnology (CDNA), Aarhus University , DK-8000 Aarhus C, Denmark.
authors.forename: Jacob
authors.initials: J
authors.lastname: Cramer
authors.affiliation: Interdisciplinary Nanoscience Center (iNANO), Center for DNA Nanotechnology (CDNA), Aarhus University , DK-8000 Aarhus C, Denmark.
authors.forename: Kurt V
authors.initials: KV
authors.lastname: Gothelf
authors.affiliation: Interdisciplinary Nanoscience Center (iNANO), Center for DNA Nanotechnology (CDNA), Aarhus University , DK-8000 Aarhus C, Denmark.
authors.forename: Mingdong
authors.initials: M
authors.lastname: Dong
authors.affiliation: Interdisciplinary Nanoscience Center (iNANO), Center for DNA Nanotechnology (CDNA), Aarhus University , DK-8000 Aarhus C, Denmark.
authors.forename: Flemming
authors.initials: F
authors.lastname: Besenbacher
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Qingdao
authors.initials: Q
authors.lastname: Zeng
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences (MOE), and Department of Physics, Fudan University , Shanghai 200433, China.
authors.forename: Guanghong
authors.initials: G
authors.lastname: Wei
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Yanlian
authors.initials: Y
authors.lastname: Yang
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival; D006801:Humans; D018625:Microscopy, Atomic Force; D016252:Microscopy, Scanning Tunneling; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry* / Q000633:toxicity; D066329:Protein Aggregates; D017433:Protein Structure, Secondary; D011725:Pyridines / Q000737:chemistry* / Q000633:toxicity; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D016229:Amyloid beta-Peptides; D009842:Oligopeptides; D010446:Peptide Fragments; D066329:Protein Aggregates; D011725:Pyridines; C075222:amyloid beta-protein (1-42)
keywords: amyloid cytotoxicity; amyloid β (Aβ) peptide; inhibitory effect; peptide aggregation; peptide motif; polymorphism effect; scanning tunneling microscopy