title: Percutaneous absorption of benzophenone-3 loaded lipid nanoparticles and polymeric nanocapsules: A comparative study.
abstract: For the last years, the increase of the number of skin cancer cases led to a growing awareness of the need of skin protection against ultraviolet (UV) radiations. Chemical UV filters are widely used into sunscreen formulations as benzophenone-3 (BP-3), a usually used broad spectrum chemical UV filter that has been shown to exercise undesirable effects after topical application. Innovative sunscreen formulations are thus necessary to provide more safety to users. Lipid carriers seem to be a good alternative to formulate chemical UV filters reducing their skin penetration while maintaining good photo-protective abilities. The aim of this work was to compare percutaneous absorption and cutaneous bioavailability of BP-3 loaded into solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), nanostructured polymeric lipid carriers (NPLC) and nanocapsules (NC). Particle size, zeta potential and in vitro sun protection factor (SPF) of nanoparticle suspensions were also investigated. Results showed that polymeric lipid carriers, comprising NPLC and NC, significantly reduced BP-3 skin permeation while exhibiting the highest SPF. This study confirms the interesting potential of NPLC and NC to formulate chemical UV filters.
authors.affiliation: Université Claude Bernard Lyon 1, Faculté de Pharmacie de Lyon, Laboratoire de Pharmacie Galénique Industrielle, Plateforme FRIPHARM, EA 4169 " Fundamental, clinical and therapeutic aspects of the skin barrier function ", 8 avenue Rockefeller, F-69373 Lyon cedex 08, France. Electronic address: elodiegilbert24@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Gilbert
authors.affiliation: Université Claude Bernard Lyon 1, Faculté de Pharmacie de Lyon, Laboratoire de Pharmacie Galénique Industrielle, Plateforme FRIPHARM, EA 4169 " Fundamental, clinical and therapeutic aspects of the skin barrier function ", 8 avenue Rockefeller, F-69373 Lyon cedex 08, France.
authors.forename: L
authors.initials: L
authors.lastname: Roussel
authors.affiliation: Université Claude Bernard Lyon 1, Faculté de Pharmacie de Lyon, Laboratoire de Pharmacie Galénique Industrielle, Plateforme FRIPHARM, EA 4169 " Fundamental, clinical and therapeutic aspects of the skin barrier function ", 8 avenue Rockefeller, F-69373 Lyon cedex 08, France.
authors.forename: C
authors.initials: C
authors.lastname: Serre
authors.affiliation: Université Claude Bernard Lyon 1, Faculté de Pharmacie de Lyon, Laboratoire de Pharmacie Galénique Industrielle, Plateforme FRIPHARM, EA 4169 " Fundamental, clinical and therapeutic aspects of the skin barrier function ", 8 avenue Rockefeller, F-69373 Lyon cedex 08, France.
authors.forename: R
authors.initials: R
authors.lastname: Sandouk
authors.affiliation: Université Claude Bernard Lyon 1, Faculté de Pharmacie de Lyon, Laboratoire de Pharmacie Galénique Industrielle, Plateforme FRIPHARM, EA 4169 " Fundamental, clinical and therapeutic aspects of the skin barrier function ", 8 avenue Rockefeller, F-69373 Lyon cedex 08, France; Service Pharmaceutique, Plateforme FRIPHARM, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, 5, place d'Arsonval, F-69437 Lyon cedex 03, France.
authors.forename: D
authors.initials: D
authors.lastname: Salmon
authors.affiliation: Université Claude Bernard Lyon 1, Faculté de Pharmacie de Lyon, Laboratoire de Pharmacie Galénique Industrielle, Plateforme FRIPHARM, EA 4169 " Fundamental, clinical and therapeutic aspects of the skin barrier function ", 8 avenue Rockefeller, F-69373 Lyon cedex 08, France.
authors.forename: P
authors.initials: P
authors.lastname: Kirilov
authors.affiliation: Université Claude Bernard Lyon 1, Faculté de Pharmacie de Lyon, Laboratoire de Pharmacie Galénique Industrielle, Plateforme FRIPHARM, EA 4169 " Fundamental, clinical and therapeutic aspects of the skin barrier function ", 8 avenue Rockefeller, F-69373 Lyon cedex 08, France.
authors.forename: M
authors.initials: M
authors.lastname: Haftek
authors.affiliation: Université Claude Bernard Lyon 1, Faculté de Pharmacie de Lyon, Laboratoire de Pharmacie Galénique Industrielle, Plateforme FRIPHARM, EA 4169 " Fundamental, clinical and therapeutic aspects of the skin barrier function ", 8 avenue Rockefeller, F-69373 Lyon cedex 08, France.
authors.forename: F
authors.initials: F
authors.lastname: Falson
authors.affiliation: Université Claude Bernard Lyon 1, Faculté de Pharmacie de Lyon, Laboratoire de Pharmacie Galénique Industrielle, Plateforme FRIPHARM, EA 4169 " Fundamental, clinical and therapeutic aspects of the skin barrier function ", 8 avenue Rockefeller, F-69373 Lyon cedex 08, France; Service Pharmaceutique, Plateforme FRIPHARM, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, 5, place d'Arsonval, F-69437 Lyon cedex 03, France.
authors.forename: F
authors.initials: F
authors.lastname: Pirot
mesh_terms: D000818:Animals; D001577:Benzophenones / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D008055:Lipids / Q000008:administration & dosage / Q000737:chemistry; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*; D059405:Sun Protection Factor; D013473:Sunscreening Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D013552:Swine
chemical_list: D001577:Benzophenones; D008055:Lipids; D053769:Nanocapsules; D011108:Polymers; D013473:Sunscreening Agents; C005290:oxybenzone
keywords: Chemical UV-filters; Cutaneous bioavailability; In vitro sun protection factor; Lipid nanocarriers; Percutaneous absorption