title: Effectiveness of intragastric balloon for obesity: A systematic review and meta-analysis based on randomized control trials.
abstract: BACKGROUND
  Obesity has become a worldwide epidemic, and many methods are currently used to reduce obesity. This systematic review shows the effectiveness of the intragastric balloon (IGB) method compared to the sham/diet (s/d) method.
  
  
  OBJECTIVE
  To demonstrate the effectiveness of the IGB method compared to the s/d method.
  
  
  METHODS
  Hospital das Clinicas da Universidade de São Paulo, Brazil, Public Hospital.
  
  
  METHODS
  After searching MEDLINE, Embase, Cochrane, Lilacs, Scopus, and CINAHL, only enrolled randomized control trials comparing IGB/diet with s/d were analyzed. For qualitative analysis, 12 studies were selected, and 9 of these were acceptable for quantitative analysis.
  
  
  RESULTS
  The IGB/diet is more effective than s/d when comparing body mass index (BMI) loss with a mean difference of 1.1 kg/m(2) by the Student's t test and 1.41 kg/m(2) by the meta-analysis, with significant differences in both. It is also more effective in weight loss (WL), with a mean difference of 2 kg by the Student's t test and 3.55 kg by the meta-analysis. In the qualitative analysis of % excess WL (%EWL), the mean %EWL is 14.0% in favor of the IGB group compared to the s/d group by the Student's t test; however, no significant difference was found between these groups by quantitative analysis.
  
  
  CONCLUSIONS
  Based on randomized control trial data alone, IGB>400 mL is more effective than sham/diet in achieving BMI loss, WL, and %EWL.
authors.affiliation: Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil. Electronic address: dthmoura@hotmail.com.
authors.forename: Diogo
authors.initials: D
authors.lastname: Moura
authors.affiliation: Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.
authors.forename: Joel
authors.initials: J
authors.lastname: Oliveira
authors.affiliation: Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.
authors.forename: Eduardo G H
authors.initials: EG
authors.lastname: De Moura
authors.affiliation: Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.
authors.forename: Wanderlei
authors.initials: W
authors.lastname: Bernardo
authors.affiliation: Obeso Center, São Paulo, Brasil.
authors.forename: Manuel
authors.initials: M
authors.lastname: Galvão Neto
authors.affiliation: Universidade Federal do Pernambuco, Recife, Brasil.
authors.forename: Josemberg
authors.initials: J
authors.lastname: Campos
authors.affiliation: New York University School of Medicine, New York, New York.
authors.forename: Violeta B
authors.initials: VB
authors.lastname: Popov
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Cristopher
authors.initials: C
authors.lastname: Thompson
mesh_terms: D015905:Gastric Balloon; D006801:Humans; D009767:Obesity, Morbid / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D015431:Weight Loss
keywords: Diet; Intragastric balloon; Obesity; Randomized