title: Seronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia Gravis.
abstract: Background Myasthenia gravis (MG) is an autoimmune disorder with fluctuating muscle weakness, divided into generalized and localized (ocular) forms. Maternal antibodies to acetylcholine receptors cross the placenta and may cause transient neonatal myasthenia gravis (TNMG). We present a case of seronegative maternal ocular MG and delayed TNMG. Case A 29-year-old G3P1011 underwent cesarean birth of a male infant who developed oxygen desaturation requiring supplemental oxygen on day of life (DOL) 3. Based on the clinical course and after exclusion of other diagnoses, the infant was diagnosed with TNMG. Infant's condition improved spontaneously and he was weaned off supplemental oxygen and discharged home on DOL 12. Conclusion Infants born to mothers with seronegative localized (ocular) MG are also susceptible to TNMG which may be late in onset.
authors.affiliation: Division of Maternal Fetal Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.
authors.forename: Courtney
authors.initials: C
authors.lastname: Townsel
authors.affiliation: Division of Maternal Fetal Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Keller
authors.affiliation: Division of Neonatology, Connecticut Children's Medical Center, Farmington, Connecticut.
authors.forename: Kendall
authors.initials: K
authors.lastname: Johnson
authors.affiliation: Division of Neonatology, Connecticut Children's Medical Center, Farmington, Connecticut.
authors.forename: Naveed
authors.initials: N
authors.lastname: Hussain
authors.affiliation: Division of Maternal Fetal Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.
authors.forename: Winston A
authors.initials: WA
authors.lastname: Campbell
keywords: ocular myasthenia gravis; pregnancy; transient neonatal myasthenia gravis