title: Design and Characterization of Metformin-Loaded Solid Lipid Nanoparticles for Colon Cancer.
abstract: Colorectal cancer is a global concern, and its treatment is fraught with non-selective effects including adverse side effects requiring hospital visits and palliative care. A relatively safe drug formulated in a bioavailability enhancing and targeting delivery platform will be of significance. Metformin-loaded solid lipid nanoparticles (SLN) were designed, optimized, and characterized for particle size, zeta potential, drug entrapment, structure, crystallinity, thermal behavior, morphology, and drug release. Optimized SLN were 195.01 ± 6.03 nm in size, -17.08 ± 0.95 mV with regard to surface charge, fibrous in shape, largely amorphous, and release of metformin was controlled. The optimized size, charge, and shape suggest the solid lipid nanoparticles will migrate and accumulate in the colon tumor preventing its proliferation and subsequently leading to tumor shrinkage and cell death.
authors.affiliation: Biomaterials and Drug Delivery Unit, Faculty of Pharmaceutical Sciences, University of Jos, Jos, 930001, Nigeria. Ndidi.Ngwuluka@biodrudel.com.
authors.forename: Ndidi C
authors.initials: NC
authors.lastname: Ngwuluka
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga (E), Mumbai, 400019, Maharashtra, India.
authors.forename: Darsheen J
authors.initials: DJ
authors.lastname: Kotak
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga (E), Mumbai, 400019, Maharashtra, India.
authors.forename: Padma V
authors.initials: PV
authors.lastname: Devarajan
mesh_terms: D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D008055:Lipids / Q000737:chemistry*; D008687:Metformin / Q000737:chemistry* / Q000627:therapeutic use; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size
chemical_list: D004337:Drug Carriers; D008055:Lipids; D008687:Metformin
keywords: colorectal cancer; controlled release; metformin; oral drug delivery; solid lipid nanoparticles