title: An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals.
abstract: Acute disseminated encephalomyelitis (ADEM) followed by optic neuritis (ON) has been reported as a distinct phenotype associated with anti-myelin oligodendrocyte protein (MOG) antibody. We herein report the case of a 37-year-old woman who was diagnosed with ADEM at 4 years old of age and who subsequently developed ON followed by recurrent ADEM 33 years after the initial onset. A serum analysis showed anti-MOG antibody positivity. This phenotype has only previously been reported in pediatric cases. Neurologists thus need to be aware that the phenotype may occur in adult patients, in whom it may be assumed to be atypical multiple sclerosis.
authors.affiliation: Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Numa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kasai
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kondo
authors.forename: Yukie
authors.initials: Y
authors.lastname: Kushimura
authors.forename: Ayaka
authors.initials: A
authors.lastname: Kimura
authors.forename: Hisashi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kanako
authors.initials: K
authors.lastname: Morita
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tanaka
authors.forename: Yu-Ichi
authors.initials: Y
authors.lastname: Noto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ohara
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Toshiki
authors.initials: T
authors.lastname: Mizuno
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001323:Autoantibodies / Q000097:blood*; D003937:Diagnosis, Differential; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000276:immunology*; D009902:Optic Neuritis / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D011239:Prednisolone / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D001323:Autoantibodies; D063308:Myelin-Oligodendrocyte Glycoprotein; D011239:Prednisolone