title: Temperature homeostasis in mice lacking the p43 mitochondrial T3 receptor.
abstract: Thyroid hormones and Thra gene play a key role in energy expenditure regulation, temperature homeostasis, and mitochondrial function. To decipher the function of the mitochondrial TRα receptor in these phenomena, we used mice lacking specifically the p43 mitochondrial T3 receptor. We found that these animals were hypermetabolic, hyperphagic, and displayed a down setting of the core body temperature. However, p43-/- animals do not present cold intolerance or defect of facultative thermogenesis. In addition, the mitochondrial function of BAT is slightly affected in the absence of p43. Our study, therefore, suggests a complementarity of action between the mitochondrial receptor and other proteins encoded by the Thra gene in the control of basal metabolism, facultative thermogenesis, and determination of the set point of temperature regulation.
authors.affiliation: INRA, UMR866 Dynamique Musculaire et Métabolisme, Université Montpellier, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Bertrand-Gaday
authors.affiliation: INRA, UMR866 Dynamique Musculaire et Métabolisme, Université Montpellier, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Pessemesse
authors.affiliation: INRA, UMR866 Dynamique Musculaire et Métabolisme, Université Montpellier, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Cabello
authors.affiliation: INRA, UMR866 Dynamique Musculaire et Métabolisme, Université Montpellier, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Wrutniak-Cabello
authors.affiliation: INRA, UMR866 Dynamique Musculaire et Métabolisme, Université Montpellier, France.
authors.forename: François
authors.initials: F
authors.lastname: Casas
mesh_terms: D000222:Adaptation, Physiological; D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001481:Basal Metabolism; D001833:Body Temperature Regulation; D003080:Cold Temperature / Q000009:adverse effects; D056915:DNA Copy Number Variations; D004272:DNA, Mitochondrial / Q000378:metabolism; D002149:Energy Intake; D004734:Energy Metabolism; D005786:Gene Expression Regulation; D006963:Hyperphagia / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008928:Mitochondria / Q000378:metabolism*; D022722:Thermogenesis; D037021:Thyroid Hormone Receptors alpha / Q000235:genetics / Q000378:metabolism*
chemical_list: D004272:DNA, Mitochondrial; D037021:Thyroid Hormone Receptors alpha
keywords: basal metabolism; mitochondria; thermogenesis; thyroid hormones