title: Pitavastatin and carbohydrate metabolism: what is the evidence?
abstract: Statins are the cornerstone of hypolipidemic treatment but recently have been associated with increased risk of developing diabetes mellitus. However, the risk of incident diabetes is not the same among statins. Pitavastatin lowers low-density lipoprotein cholesterol and increases high-density lipoprotein cholesterol but also seems to be neutral in terms of risk of incident diabetes. Clinical and experimental evidence shows that pitavastatin increases adiponectin levels and reduces oxidative stress, effects that seem to be implicated in the beneficial effect of the drug on carbohydrate metabolism variables. Pitavastatin is a useful hypolipidemic drug, which is promising for patients with increased diabetes risk or established diabetes.
authors.affiliation: a Department of Internal Medicine, School of Medicine , University of Ioannina , Ioannina , Greece.
authors.forename: T D
authors.initials: TD
authors.lastname: Filippatos
authors.affiliation: a Department of Internal Medicine, School of Medicine , University of Ioannina , Ioannina , Greece.
authors.forename: M S
authors.initials: MS
authors.lastname: Elisaf
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000818:Animals; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D011804:Quinolines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D012306:Risk
chemical_list: D052242:Adiponectin; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011804:Quinolines; C108475:pitavastatin
keywords: Pitavastatin; adiponectin; carbohydrate; diabetes; glucose; mechanisms; oxidative stress; statin