title: Virus assembly factories in a lipid world.
abstract: Many viruses build specialized structures known as viral factories, a protected environment in which viral genome replication and morphogenesis take place. Recent findings show that viruses manipulate lipid flows to assemble these replication platforms. Viruses are thus able to create new membranes by interfering with lipid metabolism, targeting and transport; they make use of specific lipid transfer proteins (LTP) at membrane contact sites, and frequently recruit endoplasmic reticulum (ER), ER export sites, and mitochondria. Some factories, such as those built by plant and certain animal viruses, are motile membranous structures involved in intracellular or intercellular transport of the replicated viral genome. The identification of lipids and LTP subverted by viruses might lead to better understand and fight viral infections.
authors.affiliation: Cell Structure Laboratory, Centro Nacional de Biotecnología, CNB-CSIC, UAM, Campus de Cantoblanco, 28049 Madrid, Spain. Electronic address: ifernandez@cnb.csic.es.
authors.forename: Isabel
authors.initials: I
authors.lastname: Fernández de Castro
authors.affiliation: Cell Structure Laboratory, Centro Nacional de Biotecnología, CNB-CSIC, UAM, Campus de Cantoblanco, 28049 Madrid, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Tenorio
authors.affiliation: Cell Structure Laboratory, Centro Nacional de Biotecnología, CNB-CSIC, UAM, Campus de Cantoblanco, 28049 Madrid, Spain. Electronic address: crisco@cnb.csic.es.
authors.forename: Cristina
authors.initials: C
authors.lastname: Risco
mesh_terms: D000818:Animals; D001692:Biological Transport; D004721:Endoplasmic Reticulum / Q000378:metabolism; D016679:Genome, Viral; D006801:Humans; D050356:Lipid Metabolism; D008928:Mitochondria / Q000378:metabolism; D010944:Plants / Q000821:virology; D019065:Virus Assembly; D018406:Virus Physiological Phenomena; D014779:Virus Replication