title: Coronary artery atherosclerosis associated with shift work in chemical plant workers by using coronary CT angiography.
abstract: The aim of this study was to investigate whether shift work is related to elevated risk of coronary artery disease (CAD) by determining the coronary artery calcium (CAC) score and the presence of coronary artery stenosis by using coronary artery CT angiography (CCTA).
  
  
  
  In this study, 110 male workers participated and underwent a CCTA examination for CAC scoring, which represents coronary artery plaque, and were evaluated for luminal stenosis. All of the participants were working in the same chemical plant, of whom 70 worked day shifts and 40 worked rotating shifts.
  
  
  
  In a multivariate logistic regression analysis, including age, smoking status, alcohol consumption, regular exercise and waist circumference, shift work was associated with a 2.89-fold increase in the odds of developing coronary plaque compared with day work (OR, 2.89; 95% CI 1.07 to 7.82). The association between shift work and coronary plaque was strong after adjustment for age, low-density lipoprotein cholesterol, hypertension and diabetes mellitus (OR, 2.92; 95% CI 1.02 to 8.33). In addition, the number of years of shift work employment was associated with coronary plaque. However, no association was found between shift work and coronary artery stenosis.
  
  
  
  Shift work could induce CAD onset via the atherosclerotic process, and shift work employment duration was associated with an increased risk of atherosclerosis in male workers.
authors.affiliation: Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, Republic of Korea.
authors.forename: WonYang
authors.initials: W
authors.lastname: Kang
authors.affiliation: Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, Republic of Korea.
authors.forename: Won-Ju
authors.initials: WJ
authors.lastname: Park
authors.affiliation: Department of Occupational and Environmental Medicine, Mokpo Christian Hospital, Mokpo, Jeollanam-do, Republic of Korea.
authors.forename: Keun-Ho
authors.initials: KH
authors.lastname: Jang
authors.affiliation: Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, Republic of Korea.
authors.forename: Soo-Hyeon
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, Republic of Korea.
authors.forename: Do-Hyeong
authors.initials: DH
authors.lastname: Gwon
authors.affiliation: Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, Republic of Korea.
authors.forename: Hyeong-Min
authors.initials: HM
authors.lastname: Lim
authors.affiliation: Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, Republic of Korea.
authors.forename: Ji-Sung
authors.initials: JS
authors.lastname: Ahn
authors.affiliation: Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, Republic of Korea.
authors.forename: Jai-Dong
authors.initials: JD
authors.lastname: Moon
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000209:etiology*; D002617:Chemical Industry; D000072226:Computed Tomography Angiography; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000209:etiology*; D003331:Coronary Vessels / Q000473:pathology; D004651:Employment; D006801:Humans; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009784:Occupational Diseases / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D055105:Waist Circumference; D014937:Work; D014940:Work Schedule Tolerance