title: Castleman's disease of a submandibular mass diagnosed on Fine Needle Cytology: Report of a case with histopathological, immunocytochemical and imaging correlations.
abstract: Castleman's disease (CD) is an unusual inflammatory lymphoproliferative disorder of uncertain aetiology, mainly involving lymphatic tissue in the mediastinum, but also occurring in the neck, lung, abdomen, pelvis, skeletal muscle and retroperitoneum. Fine Needle Cytology (FNC) is a quick, cost-effective and safe diagnostic modality to investigate on organs involved by CD, also providing a guide to treatment and management of patients with lymphoadenopathy. We report a case of a 44-year-old man who underwent FNC of a submandibular mass with subsequent surgical excision. Cytology revealed an atypical lymphoproliferative process, which arose the suspicion of CD. Histopathological study of the excised masses combined with immunhistochemistry and imaging of the submandibular and neck areas, confirmed the suspicion. A final diagnosis of Unicentric Castleman's disease, hyaline-vascular type, was made.
authors.affiliation: S.S.D. di Citopatologia e S.C. di Anatomia Patologica, Istituto Nazionale Tumori "Fondazione G. Pascalea", Napoli, Italy.
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Malzone
authors.affiliation: S.S.D. di Citopatologia e S.C. di Anatomia Patologica, Istituto Nazionale Tumori "Fondazione G. Pascalea", Napoli, Italy.
authors.forename: Anna Cipolletta
authors.initials: AC
authors.lastname: Campanile
authors.affiliation: S.S.D. di Citopatologia e S.C. di Anatomia Patologica, Istituto Nazionale Tumori "Fondazione G. Pascalea", Napoli, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Sanna
authors.affiliation: S.C. Maxillo Facciale - Otorinolaringoiatria, Istituto Nazionale Tumori "Fondazione G. Pascale", Napoli, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Ionna
authors.affiliation: S.C. Maxillo Facciale - Otorinolaringoiatria, Istituto Nazionale Tumori "Fondazione G. Pascale", Napoli, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Longo
authors.affiliation: S.S.D. di Citopatologia e S.C. di Anatomia Patologica, Istituto Nazionale Tumori "Fondazione G. Pascalea", Napoli, Italy.
authors.forename: Annarosaria
authors.initials: A
authors.lastname: De Chiara
authors.affiliation: S.C. Radiodiagnostica 1, Dipt. Diagnostica per immagini - Terapia Radiante e Metabolica, Istituto Nazionale Tumori "Fondazione G. Pascale", Napoli, Italy.
authors.forename: Sergio Venanzio
authors.initials: SV
authors.lastname: Setola
authors.affiliation: S.S.D. di Citopatologia e S.C. di Anatomia Patologica, Istituto Nazionale Tumori "Fondazione G. Pascalea", Napoli, Italy.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Botti
authors.affiliation: Servizio di Citopatologia Clinica, Istituto Cantonale di Patologia, Locarno, Switzerland.
authors.forename: Franco
authors.initials: F
authors.lastname: Fulciniti
keywords: Lymphoproliferative disorder; aspiration cytology; hyaline vascular type