title: Hydrogen Proton Magnetic Resonance Spectroscopy in Multidomain Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment Without Dementia.
abstract: To investigate the value of hydrogen proton magnet resonance spectroscopy ((1)H-MRS) in the differential diagnosis of multiple-domain amnestic mild cognitive impairment (M-aMCI) and vascular cognitive impairment with no dementia (VCIND); (1)H-MRS was performed in patients with M-aMCI and VCIND. The level was determined for N-acetylaspartate (NAA), glutamate (Glu), inositol (mI), choline (Cho), and creatine (Cr). Compared with the normal control group, the NAA-Cr ratio in all regions studied was significantly lower in the M-aMCI and VCIND groups. The Glu-Cr ratio in the posterior cingulate gyrus of the M-aMCI group was significantly lower than in the VCIND. The mI-Cr ratio in the frontal white matter of the VCIND was significantly higher than in the M-aMCI group. In the white matter adjacent to the lateral ventricles, the Cho-Cr ratio was significantly higher in the VCIND than the M-aMCI. Our results suggested (1)H-MRS is an effective method in the differential diagnosis of M-aMCI and VCIND.
authors.affiliation: Department of Radiology, The Affiliated Suzhou Hospital, Nanjing Medical University, Suzhou, China sznaonao@163.com.
authors.forename: Shuang-Qing
authors.initials: SQ
authors.lastname: Chen
authors.affiliation: Department of Radiology, The Affiliated Suzhou Hospital, Nanjing Medical University, Suzhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Cai
authors.affiliation: Department of Radiology, The Affiliated Suzhou Hospital, Nanjing Medical University, Suzhou, China.
authors.forename: Yu-Ying
authors.initials: YY
authors.lastname: Shen
authors.affiliation: Department of Radiology, The Affiliated Suzhou Hospital, Nanjing Medical University, Suzhou, China.
authors.forename: Chuan-Xiao
authors.initials: CX
authors.lastname: Xu
authors.affiliation: Department of Neurology, The Affiliated Suzhou Hospital, Nanjing Medical University, Suzhou, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Neurology, The Affiliated Suzhou Hospital, Nanjing Medical University, Suzhou, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D000368:Aged; D000647:Amnesia / Q000000981:diagnostic imaging*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging*; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*
keywords: Alzheimer’s disease; magnet resonance spectroscopy; multi-domain amnestic mild cognitive impairment; vascular cognitive impairment without dementia