title: [Meta-analysis of anti-GP210 antibody and anti-SP100 antibody detection for diagnosis of primary biliary cirrhosis].
abstract: OBJECTIVE
  To conduct a systematic review of studies assessing the association of anti-GP210 antibody and anti-SP100 antibody with diagnosis of primary biliary cirrhosis (PBC) using meta-analysis.
  
  
  METHODS
  Five research literature databases, including the Cochrane Library, MEDLINE, VIP, CNKI and WanFang, were searched for studies of anti-GP210 antibody and anti-SP100 antibody in diagnosis of PBC. Meta-disc statistical software was used for analysis.
  
  
  RESULTS
  The meta-analysis included a total of 25 studies on anti-GP210 antibody and 21 studies on anti-SP100 antibody. The diagnostic odds ratio, sensitivity, and specificity of anti-GP210 antibody for diagnosis of PBC were 24.854 (11.957-51.660), 0.272 (0.257-0.288), and 0.985 (0.982-0.988), respectively, and for anti-SP100 antibody they were 9.133 (4.739-17.600), 0.231 (0.213-0.249), and 0.977 (0.973-0.981), respectively.
  
  
  CONCLUSIONS
  Both anti-GP210 antibody and anti-SP100 antibody show high specificity but low sensitivity in diagnosis of PBC.
authors.affiliation: Key Laborator of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: H M
authors.initials: HM
authors.lastname: Deng
authors.affiliation: Key Laborator of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: S L
authors.initials: SL
authors.lastname: Hu
authors.affiliation: Department of Laboratory, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: W X
authors.initials: WX
authors.lastname: Chen
authors.affiliation: Key Laborator of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
mesh_terms: D034961:Antigens, Nuclear / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis*; D028861:Nuclear Pore Complex Proteins / Q000276:immunology; D012680:Sensitivity and Specificity; D012984:Software
chemical_list: D034961:Antigens, Nuclear; D001323:Autoantibodies; D001324:Autoantigens; C063865:NUP210 protein, human; D028861:Nuclear Pore Complex Proteins; C066642:SP100 protein, human