title: Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer's Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study.
abstract: Nutritional interventions have shown varied efficacy on cognitive performance during Alzheimer's disease (AD). Twenty-four individuals diagnosed with AD received a nutraceutical formulation (NF: folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) under open-label conditions (ClinicalTrials.gov NCT01320527). Primary outcome was cognitive performance. Secondary outcomes were behavioral and psychological symptoms of dementia (BPSD) and activities of daily living. Participants maintained their baseline cognitive performance and BPSD over 12 months. These findings are consistent with improvement in cognitive performance and BPSD in prior placebo-controlled studies with NF, and contrast with the routine decline for participants receiving placebo.
authors.affiliation: University of Massachusetts Lowell, Lowell, MA, USA.
authors.forename: Ruth
authors.initials: R
authors.lastname: Remington
authors.affiliation: Framingham State University, Framingham, MA, USA.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Bechtel
authors.affiliation: Advanced Memory Dynamics, Layton, UT, USA.
authors.forename: David
authors.initials: D
authors.lastname: Larsen
authors.affiliation: Worcester State University, Worcester, MA, USA.
authors.forename: Annemarie
authors.initials: A
authors.lastname: Samar
authors.affiliation: Framingham State University, Framingham, MA, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Page
authors.affiliation: Loyola University Maryland, Baltimore, MD, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Morrell
authors.affiliation: University of Massachusetts Lowell, Lowell, MA, USA.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Shea
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications*; D003072:Cognition Disorders / Q000178:diet therapy* / Q000209:etiology; D019587:Dietary Supplements; D018450:Disease Progression; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000178:diet therapy* / Q000209:etiology; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D013997:Time Factors; D014805:Vitamin B 12 / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000627:therapeutic use
chemical_list: D005492:Folic Acid; D024502:alpha-Tocopherol; D014805:Vitamin B 12
keywords: Alzheimer’s disease; behavioral symptoms; cognitive performance; mood; nutraceutical formulation