title: Extensive versus functional endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps and asthma: A 1-year study.
abstract: BACKGROUND
  Functional endoscopic sinus surgery (FESS) is considered to be the standard procedure for chronic rhinosinusitis with nasal polyps (CRSwNP). However, for CRSwNP that accompanies asthma, the results are not satisfying. Extensive endoscopic sinus surgery (EESS) aimed at reducing the inflammatory load has been indicated as a viable option for refractory chronic rhinosinusitis.
  
  
  OBJECTIVE
  To evaluate the clinical outcomes and safety of EESS (middle turbinate and superior turbinate resection and total ethmoidectomy) for patients with CRSwNP and with asthma.
  
  
  METHODS
  This was a prospective, single-institute cohort study conducted in a tertiary teaching hospital. Patients with CRSwNP and with asthma who were proceeding to surgery were enrolled. There were 23 patients in the EESS group and 24 patients in the FESS group. The preoperative disease severity was evaluated by the visual analog scale (VAS), Lund-Kennedy (L-K) endoscopy score, computed tomography Lund-Mackay score, asthma control test (ACT), and pulmonary function test. Clinical outcomes were comparatively evaluated between the two groups after a 1-year follow-up by using the VAS score, the postoperative endoscopic score (E score), L-K score, ACT score, and pulmonary function test.
  
  
  RESULTS
  The disease severity (general VAS score, endoscopic L-K score, computed tomography score, ACT score) showed no significant differences between the two groups before surgery (p > 0.05). One year after surgery, both groups achieved significant improvement in the VAS score and endoscopic L-K score. The EESS group showed better improvement in the olfactory VAS score and E score compared with the FESS group (mean [standard deviation] change of olfactory VAS, 6.00 ± 3.67 versus 3.30 ± 3.44, p = 0.015; mean [standard deviation] E score, 0.31 ± 0.18 versus 0.66 ± 0.26, p < 0.001). No significant differences were found in the change of general nasal symptom VAS score, other individual VAS scores (nasal congestion, discharge, headache and/or facial pain), L-K score, ACT score, and pulmonary function between the two groups (p > 0.05).
  
  
  CONCLUSIONS
  EESS for patients with CRSwNP and with asthma may help to improve the subjective olfaction and endoscopic appearance.
authors.affiliation: Allergy and Cancer Center, Otorhinolaryngology Hospital, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Feng-Hong
authors.initials: FH
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Deng
authors.forename: Hai-Yu
authors.initials: HY
authors.lastname: Hong
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.forename: Jie-Bo
authors.initials: JB
authors.lastname: Guo
authors.forename: Wei-Jian
authors.initials: WJ
authors.lastname: Hou
authors.forename: Yue-Qi
authors.initials: YQ
authors.lastname: Sun
authors.forename: Yin-Yan
authors.initials: YY
authors.lastname: Lai
authors.forename: Hua-Bin
authors.initials: HB
authors.lastname: Li
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Shi
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications / Q000601:surgery*; D002908:Chronic Disease; D015331:Cohort Studies; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000601:surgery*; D011446:Prospective Studies; D012129:Respiratory Function Tests; D012220:Rhinitis / Q000150:complications / Q000601:surgery*; D012225:Rhinoplasty; D012852:Sinusitis / Q000150:complications / Q000601:surgery*; D012903:Smell; D014057:Tomography, X-Ray Computed; D014420:Turbinates / Q000000981:diagnostic imaging / Q000601:surgery*