title: [Strategies on the improvement of chronic migraine treatment efficacy].
abstract: OBJECTIVE
  To determine the efficacy of type A botulinum toxin (lantox) in the treatment of chronic migraine.
  
  
  METHODS
  Authors examined 22 patients with chronic migraine at baseline and 4 and 12 weeks after the introduction of 150 U of lantox in head and cervical muscles using "follow the pain method". The drug was introduced into the following muscles: m. corrugator, m. procerus, m. frontalis, m. temporalis and m. оccipitalis. Clinical/neurological examinations, a study of the emotional sphere (anxiety and depression), daily activities, quality-of-life, patient's completion of questionnaires on the subjective satisfaction with treatment were carried out.
  
  
  CONCLUSIONS
  There was a significant positive effect of treatment on the frequency of headache attacks that was important for reverse transformation of chronic pain to episodic headache. Barriers in compliance may be overcome by solving psychological problems, in particular, overcoming depression. The prescription of the drug with no side-effects and fast results allows to support the adherence of the patient to treatment.
authors.affiliation: Alexander Vein Headache Clinic, Moscow.
authors.forename: M V
authors.initials: MV
authors.lastname: Naprienko
authors.affiliation: Alexander Vein Headache Clinic, Moscow.
authors.forename: L V
authors.initials: LV
authors.lastname: Smekalkina
mesh_terms: D000203:Activities of Daily Living; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000502:physiology / Q000627:therapeutic use*; D059350:Chronic Pain / Q000188:drug therapy* / Q000523:psychology; D003863:Depression / Q000523:psychology; D011307:Drug Prescriptions; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*; D010349:Patient Compliance; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D019274:Botulinum Toxins, Type A