title: Facile Assembly of Benzo[b]naphtho[2,3-d]azocin-6(5 H)-ones by a Palladium-Catalyzed Double Carbometalation.
abstract: The palladium-catalyzed reaction of 2-alkynylanilines with 2-(2-bromobenzylidene)cyclobutanone as an efficient route to 7,8-dihydrobenzo[b]naphtho[2,3-d]azocin-6(5 H)-ones was developed. The fused eight-membered ring was constructed conveniently. During the reaction process, double carbometalation was involved, which resulted in excellent selectivity with the formation of three new bonds. This transformation is highly efficient and leads to fused polycycles in good to excellent yields with good functional group tolerance.
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China.
authors.forename: Xinxing
authors.initials: X
authors.lastname: Gong
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, 419 Fangxie Road, Shanghai, 200011, China.
authors.forename: Mo
authors.initials: M
authors.lastname: Chen
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, 419 Fangxie Road, Shanghai, 200011, China. yaoliangqingcn@126.com.
authors.forename: Liangqing
authors.initials: L
authors.lastname: Yao
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China. jie_wu@fudan.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
keywords: domino reactions; fused-ring systems; nitrogen heterocycles; palladium; polycycles