title: FoodChain-Lab: A Trace-Back and Trace-Forward Tool Developed and Applied during Food-Borne Disease Outbreak Investigations in Germany and Europe.
abstract: FoodChain-Lab is modular open-source software for trace-back and trace-forward analysis in food-borne disease outbreak investigations. Development of FoodChain-Lab has been driven by a need for appropriate software in several food-related outbreaks in Germany since 2011. The software allows integrated data management, data linkage, enrichment and visualization as well as interactive supply chain analyses. Identification of possible outbreak sources or vehicles is facilitated by calculation of tracing scores for food-handling stations (companies or persons) and food products under investigation. The software also supports consideration of station-specific cross-contamination, analysis of geographical relationships, and topological clustering of the tracing network structure. FoodChain-Lab has been applied successfully in previous outbreak investigations, for example during the 2011 EHEC outbreak and the 2013/14 European hepatitis A outbreak. The software is most useful in complex, multi-area outbreak investigations where epidemiological evidence may be insufficient to discriminate between multiple implicated food products. The automated analysis and visualization components would be of greater value if trading information on food ingredients and compound products was more easily available.
authors.affiliation: Department Biological Safety, Federal Institute for Risk Assessment (BfR), Berlin, Germany.
authors.forename: Armin A
authors.initials: AA
authors.lastname: Weiser
authors.affiliation: Department Biological Safety, Federal Institute for Risk Assessment (BfR), Berlin, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Thöns
authors.affiliation: Department Biological Safety, Federal Institute for Risk Assessment (BfR), Berlin, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Filter
authors.affiliation: Department Biological Safety, Federal Institute for Risk Assessment (BfR), Berlin, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Falenski
authors.affiliation: Department Biological Safety, Federal Institute for Risk Assessment (BfR), Berlin, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Appel
authors.affiliation: Department Biological Safety, Federal Institute for Risk Assessment (BfR), Berlin, Germany.
authors.forename: Annemarie
authors.initials: A
authors.lastname: Käsbohrer
mesh_terms: D004196:Disease Outbreaks; D005060:Europe / Q000453:epidemiology; D005506:Food Contamination; D005516:Food Microbiology; D005517:Foodborne Diseases / Q000453:epidemiology*; D005858:Germany / Q000453:epidemiology; D006801:Humans; D012984:Software