title: Tissue morphodynamics: Translating planar polarity cues into polarized cell behaviors.
abstract: The ability of cells to collectively orient and align their behaviors is essential in multicellular organisms for unidirectional cilia beating, collective cell movements, oriented cell divisions, and asymmetric cell fate specification. The planar cell polarity pathway coordinates a vast and diverse array of collective cell behaviors by intersecting with downstream pathways that regulate cytoskeletal dynamics and intercellular signaling. How the planar polarity pathway translates directional cues to produce polarized cell behaviors is the focus of this review.
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: danelle@princeton.edu.
authors.forename: Danelle
authors.initials: D
authors.lastname: Devenport
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D019070:Cell Lineage; D016764:Cell Polarity; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D009024:Morphogenesis
chemical_list: D000199:Actins
keywords: Asymmetric cell division; Cell polarity; Cilia; Convergent extension; Directional signaling; Hair follicles; Planar cell polarity; Planar polarity; Stereocilia; Wing hairs