title: Sleep Apnea and Fatty Liver Are Coupled Via Energy Metabolism.
abstract: BACKGROUND
  Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by intermittent hypoxia. Non-alcoholic fatty liver disease is the most common cause of chronic liver disease worldwide. We aimed to evaluate the relationship between OSA and fatty liver.
  
  
  METHODS
  We enrolled 176 subjects to this study who underwent polysomnography (PSG) for suspected OSA. The control group included 42 simple snoring subjects. PSG, biochemical tests, and ultrasonographic examination were performed all subjects.
  
  
  RESULTS
  The simple snoring and mild, moderate, and severe OSA groups included 18/42 (42.86%), 33/52 (63.5%), 27/34 (79.4%), and 28/48 (79.2%) subjects with hepatosteatosis, respectively. There were significant differences in hepatosteatosis and hepatosteatosis grade between the simple snoring and the moderate and severe OSA groups. Logistic regression analysis showed that BMI and average desaturation were independently and significantly related to hepatic steatosis.
  
  
  CONCLUSIONS
  Our study shows that BMI and the average desaturation contribute to non-alcoholic fatty liver in subjects with OSA. In this regard, sleep apnea may trigger metabolic mitochondrial energy associated processes thereby altering lipid metabolism and obesity as well.
authors.affiliation: Department of Pulmonary Medicine, Yuzuncu Yıl University, Van, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Arısoy
authors.affiliation: Department of Pulmonary Medicine, Katip Celebi University, İzmir, Turkey.
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Sertoğullarından
authors.affiliation: Department of Pulmonary Medicine, Yuzuncu Yıl University, Van, Turkey.
authors.forename: Selami
authors.initials: S
authors.lastname: Ekin
authors.affiliation: Department of Radiology, Yuzuncu Yıl University, Van, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Özgökçe
authors.affiliation: Department of Radiology, Yuzuncu Yil University, Van, Turkey.
authors.forename: Mehmet Deniz
authors.initials: MD
authors.lastname: Bulut
authors.affiliation: Department of Biostatistics, Yuzuncu Yil University, Van, Turkey.
authors.forename: Mehmet Tahir
authors.initials: MT
authors.lastname: Huyut
authors.affiliation: Department of Gastroenterology, Yuzuncu Yıl University, Van, Turkey.
authors.forename: Şehmus
authors.initials: Ş
authors.lastname: Ölmez
authors.affiliation: Department of Otorhinolaryngology, Yuzuncu Yıl University, Van, Turkey.
authors.forename: Mahfuz
authors.initials: M
authors.lastname: Turan
mesh_terms: D000328:Adult; D019540:Area Under Curve; D016022:Case-Control Studies; D003710:Demography; D004734:Energy Metabolism; D005234:Fatty Liver / Q000150:complications* / Q000378:metabolism*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000378:metabolism*