title: How to Establish Clinical Prediction Models.
abstract: A clinical prediction model can be applied to several challenging clinical scenarios: screening high-risk individuals for asymptomatic disease, predicting future events such as disease or death, and assisting medical decision-making and health education. Despite the impact of clinical prediction models on practice, prediction modeling is a complex process requiring careful statistical analyses and sound clinical judgement. Although there is no definite consensus on the best methodology for model development and validation, a few recommendations and checklists have been proposed. In this review, we summarize five steps for developing and validating a clinical prediction model: preparation for establishing clinical prediction models; dataset selection; handling variables; model generation; and model evaluation and validation. We also review several studies that detail methods for developing clinical prediction models with comparable examples from real practice. After model development and vigorous validation in relevant settings, possibly with evaluation of utility/usability and fine-tuning, good models can be ready for the use in practice. We anticipate that this framework will revitalize the use of predictive or prognostic research in endocrinology, leading to active applications in real clinical practice.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. yholee@yuhs.ac.
authors.forename: Yong Ho
authors.identifier: http://orcid.org/0000-0002-6219-4942
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, CA, USA.
authors.forename: Heejung
authors.initials: H
authors.lastname: Bang
authors.affiliation: Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea. djkim@ajou.ac.kr.
authors.forename: Dae Jung
authors.identifier: http://orcid.org/0000-0003-1025-2044
authors.initials: DJ
authors.lastname: Kim
keywords: Clinical prediction model; Clinical usefulness; Development; Validation