title: [Immediate results of isolated chemoperfusion of the lung with melphalan and cisplatin in combination with metastasectomy in treatment for resectable metastatic lung lesions].
abstract: For treatment of metastatic lung lesions there was used the method of isolated chemoperfusion in combination with metastasectomy. The study included 74 patients (mean age 43 ± 13.4 years). There were performed 99 normothermic isolated chemoperfusions of the lung: with melphalan (39) and cisplatin (60). During surgery there were no lethality outcomes. In the immediate postoperative period it was recorded 1 (1.4%) death developed in 3 days after surgery. The cause of this death was postperfusion lung edema accompanied by increase of signs of respiratory insufficiency. There were following complications after isolated chemoperfusions of the lung: anemia--23 (23.1%), nausea--13 (13.1%), vomiting--5 (5.1%), atrial fibrillation--10 (10.1%), pneumonia-2 (2.0%), pulmonary infarction--2 (2.0%), chylothorax--1 (1.0%), pneumothorax--29 (29.3%), emphysema of soft tissues of the chest wall 73 (73.7% ). Thus isolated chemoperfusion of the lung with melphalan or cisplatin is a procedure reproducible and relatively safe.
authors.forename: E V
authors.initials: EV
authors.lastname: Levchenko
authors.forename: P S
authors.initials: PS
authors.lastname: Kalinin
authors.forename: K Yu
authors.initials: KY
authors.lastname: Senchik
authors.forename: O Yu
authors.initials: OY
authors.lastname: Mamontov
authors.lastname: L V Gorokhov
authors.forename: A S
authors.initials: AS
authors.lastname: Barchuk
authors.forename: A V
authors.initials: AV
authors.lastname: Mishchenko
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000139:chemically induced; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000209:etiology; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000009:adverse effects; D002916:Chylothorax / Q000209:etiology; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000009:adverse effects; D059146:Metastasectomy; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D011030:Pneumothorax / Q000209:etiology; D012131:Respiratory Insufficiency / Q000209:etiology / Q000517:prevention & control; D013352:Subcutaneous Emphysema / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin; D008558:Melphalan