title: Computing Substrate Selectivity in a Peptide Transporter.
abstract: The human proton-coupled peptide transporter 1 (PepT1) is responsible for the absorption of di- and tri-peptides from the diet and peptide-like drugs. In this issue of Cell Chemical Biology, Samsudin et al. (2016) use an integrated computational and experimental approach to provide new insights into understanding substrate selectivity of PepTSt, a prokaryotic homolog of the human PepT1.
authors.affiliation: Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors.forename: Claire
authors.initials: C
authors.lastname: Colas
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Smith
authors.affiliation: Departments of Pharmacology and Systems Therapeutics, and Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: avner.schlessinger@mssm.edu.
authors.forename: Avner
authors.initials: A
authors.lastname: Schlessinger
mesh_terms: D001692:Biological Transport; D006801:Humans; D010455:Peptides; D011522:Protons; D027981:Symporters / Q000378:metabolism*
chemical_list: D010455:Peptides; D011522:Protons; D027981:Symporters