title: Catalytic Asymmetric Cycloaddition of In Situ-Generated ortho-Quinone Methides and Azlactones by a Triple Brønsted Acid Activation Strategy.
abstract: A convergent and highly stereoselective [4+2] cycloaddition of in situ-generated ortho-Quinone methides (o-QMs) and azlactone enols has been successfully developed through a triple Brønsted acid catalysis strategy. This protocol provides an efficient and mild access to various densely functionalized dihydrocoumarins bearing adjacent quaternary and tertiary stereogenic centers in high yields with excellent diastereo- and enantioselectivity.
authors.affiliation: CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei, 430079, P. R. China.
authors.forename: Xiao-Ye
authors.initials: XY
authors.lastname: Yu
authors.affiliation: CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei, 430079, P. R. China. chenjiarong@mail.ccnu.edu.cn.
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Chen
authors.affiliation: CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei, 430079, P. R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.affiliation: CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei, 430079, P. R. China.
authors.forename: Hong-Gang
authors.initials: HG
authors.lastname: Cheng
authors.affiliation: CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei, 430079, P. R. China.
authors.forename: Zhi-Cheng
authors.initials: ZC
authors.lastname: Liu
authors.affiliation: CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei, 430079, P. R. China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P. R. China.
authors.forename: Wen-Jing
authors.identifier: 0000-0002-9318-6021
authors.initials: WJ
authors.lastname: Xiao
keywords: cycloaddition; heterocycles; lactones; methides; synthetic methods