title: Virulence determinants, antimicrobial susceptibility, and molecular profiles of Erysipelothrix rhusiopathiae strains isolated from China.
abstract: The aim of this study was to understand the epidemiology, serotype, antibiotic sensitivity, and clonal structure of Erysipelothrix rhusiopathiae strains in China. Forty-eight strains were collected from seven provinces during the period from 2012 to 2013. Pulse-field electrophoresis identified 32 different patterns which were classified into clonal groups A–D. Most pulsed-field gel electrophoresis (PFGE) patterns were observed in clonal complex A and B, suggesting high diversity of genetic characterization in these two predominant clonal complexes. Antibiotic sensitivity test shows that all the stains were susceptible to ampicillin, erythromycin, and cefotaxime, and resistant to kanamycin, cefazolin, sulfadiazine, and amikacin. Erythromycin and ampicillin are recommended as first-line antibiotics for treatment of E. rhusiopathiae in China. The high variation in PFGE pattern among the main clonal groups shows that the E. rhusiopathiae in China may originate from different lineages and sources instead of from expansion of a single clonal lineage across different regions.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ding
authors.forename: Dongmei
authors.initials: D
authors.lastname: Zhu
authors.forename: Jianmin
authors.initials: J
authors.lastname: Zhang
authors.forename: Longsheng
authors.initials: L
authors.lastname: Yang
authors.forename: Xiangru
authors.initials: X
authors.lastname: Wang
authors.forename: Huanchun
authors.initials: H
authors.lastname: Chen
authors.forename: Chen
authors.initials: C
authors.lastname: Tan
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002681:China / Q000453:epidemiology; D016521:Electrophoresis, Gel, Pulsed-Field / Q000379:methods; D004888:Erysipelothrix / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D004889:Erysipelothrix Infections / Q000453:epidemiology* / Q000382:microbiology*; D008099:Liver / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D012703:Serotyping; D013154:Spleen / Q000382:microbiology; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology* / Q000382:microbiology*; D037521:Virulence Factors / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D037521:Virulence Factors