title: Comparison of liver hemodynamics according to doppler ultrasonography in alcoholic patients subtyped by Cloninger classification and non-alcoholic healthy subjects.
abstract: BACKGROUND
  The aim of this study was to search for morphological and hemodynamic changes in hepatic and splanchnic vasculature in alcoholic patients without the signs of hepatic damage and subtyped by Cloninger classification by means of sonography, and compare the subtypes among themselves and with nonalcoholic healthy subjects.
  
  
  METHODS
  Thirty alcohol dependent patients and 30 healthy subjects with no alcohol problem or hepatic impairment were included in the study. Patients were subtyped by Cloninger classification and all patients were evaluated by gray-scale and spectral Doppler ultrasound. The diameter of the portal vein, portal venous velocity, peak systolic and end diastolic velocities of hepatic and superior mesenteric arteries were assessed. RI, PI and systolic/diastolic velocity ratios were also calculated.
  
  
  RESULTS
  Portal vein diameter (PV diameter), portal vein cross sectional area (PV area), portal vein velocity (PV PSV), hepatic artery peak systolic velocity (HA PSV), hepatic artery end diastolic velocity (HA EDV), hepatic artery resistive index (HA RI), hepatic artery pulsatility index (HA PI), and systolic/diastolic velocity ratios (HA S/D), superior mesenteric artery peak systolic velocity (SMA PSV), superior mesenteric artery end diastolic velocity (SMA EDV), superior mesenteric artery resistive indices (SMA RI), pulsatility index (SMA PI), and systolic/diastolic velocity rates (SMA S/D) showed no significant difference among the groups (P > 0.01). Although there is no significant difference in PV PSV, HA PSV, SMA PSV, SMA EDV values between the groups, mean values of Type II alcoholics is greater than other groups. Portal vein cross-sectional area was greater in alcoholic patients (Type I, II and III) compared to the control group (P = 0.000). Portal vein velocity, hepatic artery peak systolic and end diastolic velocity, superior mesenteric artery peak systolic and end diastolic velocity were significantly greater in alcoholic patients than in the control group (P < 0.001). No statistical difference was detected between other parameters evaluated.
  
  
  CONCLUSIONS
  In alcohol dependent patients, some hemodynamic and morphologic changes occur in hepatic and splanchnic circulation, even before the signs of hepatic damage develop, which can be detected by means of Doppler and gray-scale sonography. But as there is no significant difference between the Doppler ultrasonographic findings among alcoholics subtyped by a Cloninger classification, which is a clinical classification, it suggests that psychiatric classification doesn't show any correlation with biological parameters, and because of this Cloninger classification a psychiatric classification cannot be considered as a characteristic determinative factor in the prognosis of hepatic disorder due to alcohol use. However, higher values of Type II alcoholics can be attributed to the longer alcohol intake of this subtype.
authors.affiliation: 1Ankara Oncology Research and Training Hospital, Radiology Department.
authors.forename: Z
authors.initials: Z
authors.lastname: Sumru Cosar
authors.affiliation: 2Gazi University School of Medicine Psychiatry Department.
authors.forename: Behcet
authors.initials: B
authors.lastname: Cosar
authors.affiliation: 3Gazi University School of Medicine Radiology Department, Ankara, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Oktar
authors.affiliation: 2Gazi University School of Medicine Psychiatry Department.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Arikan
authors.affiliation: 3Gazi University School of Medicine Radiology Department, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Özdemir
authors.affiliation: 3Gazi University School of Medicine Radiology Department, Ankara, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Yücel