title: Mortality and predictors in pulmonary tuberculosis with respiratory failure requiring mechanical ventilation.
abstract: OBJECTIVE
  To analyse the predictors and mortality rate among patients receiving mechanical ventilation (MV) for respiratory failure due to pulmonary tuberculosis (TB).
  
  
  METHODS
  We retrospectively compared patients who required MV for TB with patients who required MV for community-acquired pneumonia (CAP).
  
  
  RESULTS
  In-hospital mortality was significantly different between the two groups: 95.1% in TB vs. 62.7% in CAP (P < 0.001 using the χ(2) test). TB patients had a higher 30-day mortality (P = 0.040 using log-rank test), although the median sequential organ failure assessment (SOFA) (7.0 vs. 6.0, P = 0.842) and mean Acute Physiology and Chronic Health Evaluation (APACHE) II scores (20.0 ± 6.7 vs. 21.2 ± 6.7, P = 0.379) for TB and CAP patients were not different. TB patients were more likely to have increased lung lesion intrusions (OR 1.307, 95%CI 1.042-1.641, P = 0.021), and reduced albumin (OR 0.073, 95%CI 0.016-0.335, P = 0.001), C-reactive protein (OR 0.324, 95%CI 0.146-0.716, P = 0.005) and CURB-65 score (confusion, uraemia, respiratory rate, blood pressure and age ⩾65 years) (OR 0.916, 95%CI 0.844-0.995, P = 0.037).
  
  
  CONCLUSIONS
  TB patients showed identical SOFA and APACHE II scores, but higher mortality than CAP patients. The higher mortality was not related to severity, but suggested an association with the extent of destructive lung lesions.
authors.affiliation: Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea.
authors.forename: W J
authors.initials: WJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea.
authors.forename: S-J
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea.
authors.forename: Y
authors.initials: Y
authors.lastname: Hong
authors.affiliation: Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea.
authors.forename: H-Y
authors.initials: HY
authors.lastname: Lee
authors.affiliation: Environmental Health Center, Kangwon National University Hospital, Chuncheon, Korea.
authors.forename: M-N
authors.initials: MN
authors.lastname: Lim
authors.affiliation: Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea.
authors.forename: S-S
authors.initials: SS
authors.lastname: Han
mesh_terms: D018806:APACHE; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D017714:Community-Acquired Infections / Q000401:mortality / Q000628:therapy; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000401:mortality* / Q000628:therapy*; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis; D014397:Tuberculosis, Pulmonary / Q000401:mortality* / Q000628:therapy*
chemical_list: D012709:Serum Albumin; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase