title: [Pharmacology research on PXR as a potential target in screening bioactive components of Chinese material medica].
abstract: Pregnane X receptor (PXR) is key transcription factors which mainly regulate the expression of CYP3A genes. At the molecular level, PXR has been revealed the protection mechanism of the body against xenochemicals and a major mode of the drug-drug interactions. Besides playing an important role in drug metabolism and interactions, PXR and its target genes also play an important role in maintaining normal physiological function and homeostasis. Therefore, it is necessary to study the regulation of PXR and its related pharmacological effects of TCM and natural products, and to provide new clues for the new pharmacological pathway.
authors.forename: Yu-guang
authors.initials: YG
authors.lastname: Wang
authors.forename: Xian-xie
authors.initials: XX
authors.lastname: Zhang
authors.forename: Han
authors.initials: H
authors.lastname: Li
authors.forename: Bei-bei
authors.initials: BB
authors.lastname: Lu
authors.forename: Jian-ming
authors.initials: JM
authors.lastname: Zhou
authors.forename: Hao-sheng
authors.initials: HS
authors.lastname: Liu
authors.forename: Dong-hua
authors.initials: DH
authors.lastname: Hu
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Ya-xin
authors.initials: YX
authors.lastname: Zhang
authors.forename: Zeng-chun
authors.initials: ZC
authors.lastname: Ma
authors.forename: Qian-de
authors.initials: QD
authors.lastname: Liang
authors.forename: Xiang-lin
authors.initials: XL
authors.lastname: Tang
authors.forename: Cheng-rong
authors.initials: CR
authors.lastname: Xiao
authors.forename: Hong-ling
authors.initials: HL
authors.lastname: Tan
authors.forename: Yue
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D000077297:Pregnane X Receptor; D011987:Receptors, Steroid / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D000077297:Pregnane X Receptor; D011987:Receptors, Steroid