title: [Other therapeutic strategies].
abstract: Non-selective and irreversible MAOI have become as third or fourth-line strategy for the management of treatment-resistant depression. Non-selective and irreversible MAOI requires careful monitoring of drug interactions and dietary restrictions. Nutritional supplements such as omega-3 have been found to produce beneficial effects in the management of treatment-resistant depression when administered in combination with the ongoing antidepressant treatment. The glutamate antagonist ketamine has been found to produce beneficial effects in the management of treatment-resistant depression while administered alone. Dopamine and/or norepinephrine agonists, such as methylphenidate, modafinil or pramipexole, have been found to produce beneficial effects in the management of treatment-resistant depression when administered in combination with the ongoing antidepressant treatment.
authors.affiliation: Henri-Mondor, hôpital Chenevier, pôle de psychiatrie des hôpitaux universitaires, centre expert dépression résistante FondaMental, 94000 Créteil, France. Electronic address: ghassen.saba@ach.aphp.fr.
authors.forename: Ghassen
authors.initials: G
authors.lastname: Saba
authors.affiliation: Hôpital Fernand-Widal, service de psychiatrie adulte, centre expert dépression résistante FondaMental, 75010 Paris, France.
authors.forename: Isabel
authors.initials: I
authors.lastname: Nieto
authors.affiliation: Centre hospitalier Le Vinatier, service universitaire de psychiatrie adulte, centre expert dépression résistante FondaMental, BP 300 39, 69678 Bron cedex, France.
authors.forename: Rémy
authors.initials: R
authors.lastname: Bation
authors.affiliation: Hôpital Fernand-Widal, service de psychiatrie adulte, centre expert dépression résistante FondaMental, 75010 Paris, France.
authors.forename: Najib
authors.initials: N
authors.lastname: Allaïli
authors.affiliation: CHU de Besançon, service de psychiatrie de l'adulte, centre expert dépression résistante FondaMental, 25030 Besançon cedex, France.
authors.forename: Djamila
authors.initials: D
authors.lastname: Bennabi
authors.affiliation: CHRU Lapeyronie, département des urgences et post-urgences psychiatrique, centre expert dépression résistante FondaMental, 34295 Montpellier cedex 5, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Moliere
authors.affiliation: CHU La Conception, pôle psychiatrie centre, centre expert dépression résistante FondaMental, 13005 Marseille, France.
authors.forename: Raphaëlle
authors.initials: R
authors.lastname: Richieri
authors.affiliation: CHU de Grenoble, hôpital Nord, service de psychiatrie de l'adulte, centre expert dépression résistante FondaMental, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Holtzmann
authors.affiliation: CHRU de Lille, hôpital Fontan 1, service de psychiatrie adulte, centre expert dépression résistante FondaMental, 59037 Lille cedex, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Bubrovszky
authors.affiliation: CHU de Tours, clinique psychiatrique universitaire, centre expert dépression résistante FondaMental, 37044 Tours cedex 9, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Camus
authors.affiliation: CHU de Clermont-Ferrand, service de psychiatrie de l'adulte B, centre expert dépression résistante FondaMental, 63003 Clermont-Ferrand, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Charpeaud
authors.affiliation: CHRU Lapeyronie, département des urgences et post-urgences psychiatrique, centre expert dépression résistante FondaMental, 34295 Montpellier cedex 5, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Courtet
authors.affiliation: CHU de Grenoble, hôpital Nord, service de psychiatrie de l'adulte, centre expert dépression résistante FondaMental, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Courvoisier
authors.affiliation: Centre hospitalier Le Vinatier, service universitaire de psychiatrie adulte, centre expert dépression résistante FondaMental, BP 300 39, 69678 Bron cedex, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Haesebaert
authors.affiliation: CH Charles-Perrens, pôle de psychiatrie générale et universitaire, centre expert dépression résistante FondaMental, 33076 Bordeaux cedex, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Doumy
authors.affiliation: CHU de Tours, clinique psychiatrique universitaire, centre expert dépression résistante FondaMental, 37044 Tours cedex 9, France.
authors.forename: Wissam
authors.initials: W
authors.lastname: El-Hage
authors.affiliation: CHU de Clermont-Ferrand, service de psychiatrie de l'adulte B, centre expert dépression résistante FondaMental, 63003 Clermont-Ferrand, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Garnier
authors.affiliation: Centre hospitalier Le Vinatier, service universitaire de psychiatrie adulte, centre expert dépression résistante FondaMental, BP 300 39, 69678 Bron cedex, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: d'Amato
authors.affiliation: CHU de Grenoble, hôpital Nord, service de psychiatrie de l'adulte, centre expert dépression résistante FondaMental, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Bougerol
authors.affiliation: CHU La Conception, pôle psychiatrie centre, centre expert dépression résistante FondaMental, 13005 Marseille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Lançon
authors.affiliation: CHU de Besançon, service de psychiatrie de l'adulte, centre expert dépression résistante FondaMental, 25030 Besançon cedex, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Haffen
authors.affiliation: CHU de Clermont-Ferrand, service de psychiatrie de l'adulte B, centre expert dépression résistante FondaMental, 63003 Clermont-Ferrand, France.
authors.forename: Pierre-Michel
authors.initials: PM
authors.lastname: Llorca
authors.affiliation: CHRU de Lille, hôpital Fontan 1, service de psychiatrie adulte, centre expert dépression résistante FondaMental, 59037 Lille cedex, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Vaiva
authors.affiliation: Hôpital Fernand-Widal, service de psychiatrie adulte, centre expert dépression résistante FondaMental, 75010 Paris, France.
authors.forename: Frank
authors.initials: F
authors.lastname: Bellivier
authors.affiliation: Henri-Mondor, hôpital Chenevier, pôle de psychiatrie des hôpitaux universitaires, centre expert dépression résistante FondaMental, 94000 Créteil, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
authors.affiliation: CH Charles-Perrens, pôle de psychiatrie générale et universitaire, centre expert dépression résistante FondaMental, 33076 Bordeaux cedex, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Aouizerate
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D019587:Dietary Supplements; D018491:Dopamine Agonists / Q000627:therapeutic use*; D004311:Double-Blind Method; D004347:Drug Interactions; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D005492:Folic Acid / Q000627:therapeutic use; D018565:Food-Drug Interactions; D006801:Humans; D007649:Ketamine / Q000627:therapeutic use*; D008996:Monoamine Oxidase Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012436:S-Adenosylmethionine / Q000627:therapeutic use
chemical_list: D000316:Adrenergic alpha-Agonists; D000928:Antidepressive Agents; D000697:Central Nervous System Stimulants; D018491:Dopamine Agonists; D018691:Excitatory Amino Acid Antagonists; D015525:Fatty Acids, Omega-3; D008996:Monoamine Oxidase Inhibitors; D007649:Ketamine; D012436:S-Adenosylmethionine; D005492:Folic Acid