title: Cross-Sectional and Longitudinal Associations between Serum Bilirubin and Prediabetes in a Health Screening Population.
abstract: OBJECTIVE
  Longitudinal associations between total bilirubin (TB) and prediabetes have not been reported. This study investigated cross-sectional and longitudinal associations between TB and prediabetes.
  
  
  METHODS
  Cross-sectional associations between TB and prediabetes were investigated in 3681 nondiabetic subjects. Longitudinal associations between TB and prediabetes over 6 years were investigated in 2149 subjects who were normoglycemic at baseline. Prediabetes was defined as fasting plasma glucose (FPG) levels of ≥5.6 mmol/L or glycated hemoglobin levels of ≥5.7% excluding diabetes.
  
  
  RESULTS
  The prevalence of prediabetes was 25.4%, and the cumulative incidence of prediabetes during 6 years was 25.5% in a Japanese health screening population. Prevalent prediabetes was significantly associated with the quintiles of TB in nonsmoking men (trend, p<0.001) and women (trend, p=0.012), but not in smoking men (trend, p=0.689). Incident prediabetes was not significantly associated with the quintiles of TB, while it was positively associated with 1 standard deviation increase in TB in nonsmoking men (hazard ratio [95% confidence interval]; 1.21 [1.07 to 1.37], p=0.002).
  
  
  CONCLUSIONS
  TB levels were significantly inversely associated with prevalent prediabetes in nonsmokers, but not in smokers, whereas an inverse association between TB levels and incident prediabetes seemed to be unlikely.
authors.affiliation: Medical Check-up Center, Tachikawa Medical Center, Niigata, Japan. Electronic address: ijie@venus.sannet.ne.jp.
authors.forename: Eiji
authors.initials: E
authors.lastname: Oda
mesh_terms: D001663:Bilirubin / Q000097:blood*; D001786:Blood Glucose; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008403:Mass Screening; D011236:Prediabetic State / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D016016:Proportional Hazards Models; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose; D001663:Bilirubin
keywords: bilirubine sérique; glycated hemoglobin (A1C); hémoglobine glyquée (A1c); oxidative stress; prediabetes; prédiabète; serum bilirubin; smoking; stress oxydatif; tabagisme