title: Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity.
abstract: Dendritic cells (DCs) are considered as one of the main regulators of immune responses. They collect antigens, process them, and present typical antigenic structures to lymphocytes, thereby inducing an adaptive immune response. All these processes take place under conditions of oxygen shortage (hypoxia) which is often not considered in experimental settings. This review highlights how deeply hypoxia modulates human as well as mouse immature and mature dendritic cell functions. It tries to link in vitro results to actual in vivo studies and outlines how hypoxia-mediated shaping of dendritic cells affects the activation of (innate) immunity.
authors.affiliation: Institut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Winning
authors.affiliation: Institut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Fandrey
mesh_terms: D056704:Adaptive Immunity / Q000187:drug effects*; D000818:Animals; D017951:Antigen Presentation / Q000187:drug effects; D000941:Antigens / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D000860:Hypoxia / Q000276:immunology* / Q000473:pathology; D007113:Immunity, Innate / Q000187:drug effects*; D007249:Inflammation; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D051379:Mice; D010100:Oxygen / Q000494:pharmacology*; D015398:Signal Transduction
chemical_list: D000941:Antigens; D016207:Cytokines; D010100:Oxygen