title: Antiurolithiatic effect of lithocare against ethylene glycol-induced urolithiasis in Wistar rats.
abstract: OBJECTIVE
  This study is aimed to investigate the protective effect of Lithocare (LC) (a polyherbal formulation) against ethylene glycol (EG) induced urolithiasis in Wistar rats.
  
  
  METHODS
  The protective effect of LC (400 and 800 mg/kg) was evaluated using EG-induced urolithiasis in rats.
  
  
  RESULTS
  Administration of EG in drinking water resulted in hyperoxaluria, hypocalcemia as well as an increased renal excretion of phosphate. Supplementation with LC significantly reduced the urinary calcium, oxalate, and phosphate excretion dose-dependently. There was a significant reduction in the levels of calcium, oxalate as well as a number of calcium oxalate crystals deposits in the kidney tissue of rats administered with LC in EG-treated rats. There was a significant reduction in creatinine, urea, uric acid, and blood urea nitrogen when LC was administered in EG-treated rats.
  
  
  CONCLUSIONS
  From this study, it was concluded that the supplementation of LC protected EG-induced urolithiasis as it reduced the growth of urinary stones. The mechanism underlying this effect might be due to its antioxidant, diuretic, and reduction in stone-forming constituents.
authors.affiliation: Department of Pharmacy, Sumandeep Vidyapeeth University, Piparia, Vadodara, Gujarat, India.
authors.forename: Sumaiya I
authors.initials: SI
authors.lastname: Lulat
authors.affiliation: Department of Pharmacy, Sumandeep Vidyapeeth University, Piparia, Vadodara, Gujarat, India.
authors.forename: Yogesh Chand
authors.initials: YC
authors.lastname: Yadav
authors.affiliation: Department of Pharmacy, Sumandeep Vidyapeeth University, Piparia, Vadodara, Gujarat, India.
authors.forename: R
authors.initials: R
authors.lastname: Balaraman
authors.affiliation: Department of Pharmacy, Sumandeep Vidyapeeth University, Piparia, Vadodara, Gujarat, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Maheshwari
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D019855:Ethylene Glycol / Q000633:toxicity*; D029001:Herbal Medicine; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D052878:Urolithiasis / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D019855:Ethylene Glycol
keywords: Ethylene glycol; Wistar rats; lithocare; polyherbal formulation; urolithiasis