title: Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss.
abstract: Recurrent pregnancy loss (RPL) is a condition with complex etiologies, to which both genetic and environmental factors may contribute. During the last decade, studies indicated that the expression patterns of the prokineticin receptor (PKR1 and PKR2) are closely related to early pregnancy. However, there are few studies on the role of PKR1 and PKR2 in RPL. In this study, we purpose to investigate the association between polymorphisms of the prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and RPL on a group of 93 RPL cases and 169 healthy controls. Genotyping of the single nucleotide polymorphisms (SNPs) was performed using a Sequenom MassARRAY iPLEX system. The results revealed a significant association between PKR2 rs6053283 polymorphism and RPL (P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population.
authors.affiliation: Shanghai Obstetrics/Gynecology Hospital, Fudan University, Shanghai 200011, China.
authors.forename: Yun-lei
authors.initials: YL
authors.lastname: Cao
authors.affiliation: Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, China.
authors.forename: Zhao-feng
authors.initials: ZF
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, China.
authors.forename: Mao-hua
authors.initials: MH
authors.lastname: Miao
authors.affiliation: Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, China.
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Xu
authors.affiliation: Department of Biostatistics and Epidemiology, Public Health School, Soochow University, Suzhou 215123, China.
authors.forename: Yue-ping
authors.initials: YP
authors.lastname: Shen
authors.affiliation: Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
authors.forename: Ai-min
authors.initials: AM
authors.lastname: Chen
authors.affiliation: Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Du
authors.affiliation: Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics; D002681:China / Q000208:ethnology; D005260:Female; D005768:Gastrointestinal Hormones / Q000502:physiology; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D018000:Receptors, Peptide / Q000235:genetics*; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / Q000502:physiology
chemical_list: D005768:Gastrointestinal Hormones; C467610:PROK1 protein, human; C470837:PROKR1 protein, human; C470838:PROKR2 protein, human; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
keywords: PKR2; Polymorphism; Prokineticin receptor 1 (PKR1); Recurrent pregnancy loss