title: Effect of Denosumab Administration on Lumbar Vertebral Strength of Patients with Vertebral Bony Metastases: Preliminary Study.
abstract: The purpose of this study was to examine the usefulness of administration of denosumab (antibody against tumor necrosis factor superfamily member 11) as a preventative therapy for skeletal-related events (SREs), such as fracture or paralysis, by computed-tomography (CT)-based on the finite element method (FEM). Patients who had undergone treatment for vertebral metastases with denosumab administration from December 2013 to August 2015 at our Institution were reviewed. We investigated patient data at the time before denosumab administration and at 1, 3 and 6 months using CT. A total of six patients were eligible; four males and two females, with ages ranging from 35 to 73 years, with a mean age of 56 years. Repeated measures analysis of variance showed a significant increase (p=0.0055, F=10.67). To our knowledge, this is the first article to substantiate the effects of the SRE-preventative drug denosumab.
authors.affiliation: Department of Orthopedic Surgery, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan.
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Kawanami
authors.affiliation: Spine Center, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan Department of Orthopedic Surgery, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan nwakao2009@yahoo.co.jp.
authors.forename: Norimitsu
authors.initials: N
authors.lastname: Wakao
authors.affiliation: Division of Biostatistics, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Murotani
authors.affiliation: Spine Center, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan Department of Orthopedic Surgery, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kamiya
authors.affiliation: Spine Center, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan.
authors.forename: Mikinobu
authors.initials: M
authors.lastname: Takeuchi
authors.affiliation: Spine Center, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan Department of Orthopedic Surgery, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan.
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Hirasawa
authors.affiliation: Department of Orthopedic Surgery, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Matsuo
authors.affiliation: Department of Orthopedic Surgery, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Sato
authors.affiliation: Department of Orthopedic Surgery, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Deie
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D050071:Bone Density Conservation Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001847:Bone Diseases / Q000209:etiology / Q000517:prevention & control; D001859:Bone Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D000069448:Denosumab / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D020342:Finite Element Analysis; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D000069448:Denosumab
keywords: CT-based finite element analysis; CT-based finite element method; bone metastasis; bone strength; denosumab administration