title: Pretransplantation Supportive and Palliative Care Consultation for High-Risk Hematopoietic Cell Transplantation Patients.
abstract: Early palliative care (EPC) for patients with metastatic solid tumors is now standard of care, but the effect of EPC in hematopoietic cell transplantation (HCT) is less well understood. We studied the acceptability of pre-HCT EPC as measured by trial participation, changes in patient-reported outcomes, and follow-up with palliative care providers. English-speaking adults (age >17 years) with an HCT comorbidity index of ≥ 3, relapse risk > 25%, or planned HLA-mismatched allogeneic or myeloablative HCT received EPC before HCT admission with monthly or more frequent visits. Twenty-two (69%) of 32 subjects provided consent; 2 were later excluded (HCT cancelled, consent retracted) for a 63% participation rate. Comfort with EPC was high (82% very comfortable). Subjects reported stable or improved mood and sense of hope, without apparent negative effects with a median of 3 visits. Follow-up surveys were returned by 75% of participants at 60 days and by 65% at 90 days. Four (20%) were admitted to the intensive care unit before day 100 and 3 (15%) received life-support measures. Five (25%) died with median follow-up of 14 months. EPC is feasible, acceptable, and has the potential to improve the HCT experience, whether or not the patient survives. EPC for HCT patients should be tested in a randomized trial.
authors.affiliation: Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, Washington; Division of Hematology and Oncology, University of Washington, Seattle, Washington; Palliative Care Service, Seattle Cancer Care Alliance, Seattle, Washington. Electronic address: eloggers@seattlecca.org.
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Loggers
authors.affiliation: Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University School of Medicine, Durham, North Carolina; Program in Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: LeBlanc
authors.affiliation: Bone Marrow Transplant Program, Massachusetts General Hospital Cancer Center, Boston, Massachusetts; Harvard Medical School, Boston Massachusetts.
authors.forename: Areej
authors.initials: A
authors.lastname: El-Jawahri
authors.affiliation: Palliative Care Service, Seattle Cancer Care Alliance, Seattle, Washington.
authors.forename: Judy
authors.initials: J
authors.lastname: Fihn
authors.affiliation: Palliative Care Service, Seattle Cancer Care Alliance, Seattle, Washington.
authors.forename: Molly
authors.initials: M
authors.lastname: Bumpus
authors.affiliation: Palliative Care Service, Seattle Cancer Care Alliance, Seattle, Washington.
authors.forename: Jodie
authors.initials: J
authors.lastname: David
authors.affiliation: Palliative Care Service, Seattle Cancer Care Alliance, Seattle, Washington.
authors.forename: Petr
authors.initials: P
authors.lastname: Horak
authors.affiliation: Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, Washington; Division of Hematology and Oncology, University of Washington, Seattle, Washington.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000523:psychology* / Q000592:standards; D006801:Humans; D008297:Male; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods* / Q000523:psychology / Q000592:standards; D000071066:Patient Reported Outcome Measures; D012017:Referral and Consultation; D012306:Risk; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult
keywords: Hematopoietic cell transplantation; Palliative care