title: Dithioacetal Exchange: A New Reversible Reaction for Dynamic Combinatorial Chemistry.
abstract: Reversibility of dithioacetal bond formation is reported under acidic mild conditions. Its utility for dynamic combinatorial chemistry was explored by combining it with orthogonal disulfide exchange. In such a setup, thiols are positioned at the intersection of both chemistries, constituting a connecting node between temporally separated networks.
authors.affiliation: Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario (IIDEFAR, UNR-CONICET), Ocampo y Esmeralda, Rosario, 2000), Argentina.
authors.forename: A Gastón
authors.initials: AG
authors.lastname: Orrillo
authors.affiliation: Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario (IIDEFAR, UNR-CONICET), Ocampo y Esmeralda, Rosario, 2000), Argentina.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Escalante
authors.affiliation: Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario (IIDEFAR, UNR-CONICET), Ocampo y Esmeralda, Rosario, 2000), Argentina. furlan@iidefar-conicet.gob.ar.|Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario, 2000), Argentina. furlan@iidefar-conicet.gob.ar.
authors.forename: Ricardo L E
authors.initials: RL
authors.lastname: Furlan
keywords: dithioacetal exchange; dynamic combinatorial chemistry; reversible reaction; systems chemistry