title: FKBP5 is associated with amygdala volume in the human brain and mood state: A voxel-based morphometry (VBM) study.
abstract: The present study was to investigate the effects of 6 FK506 binding protein 51 (FKBP5) single nucleotide polymorphisms (SNPs) on brain structure using voxel-based morphometry (VBM) and the psychological tests to psychological stress. We genotyped 112 healthy controls with respect to 6 SNPs (rs) of FKBP5. We examined the Beck Depression Inventory and the State (STAI-S) and Trait (STAI-T) versions of the Spielberger Anxiety Inventory and the Profile of Mood States (POMS) to evaluate mood. The right amygdala was larger in subjects with the minor allele (C) of rs3800373 and rs992105 and the minor allele (T) of rs1360780. The right middle orbitofrontal region in those with the minor allele (C) of rs3800373 and the right inferior orbitofrontal region in those with the minor allele (T) of rs9470080 was larger. Both the amygdala volumes were associated significantly with FKBP5 SNPs. We found significant relationships between factors in POMS and the right and left amygdala and left insula. Our results suggest that FKBP5 SNPs are associated with the alternations of volumes in right amygdala and the right middle and inferior orbitofrontal region. Genetic variants of FKBP5 may be associated with depressive and anxiety state via differential effects on amygdala and orbitofrontal region.
authors.affiliation: a Department of Neuropsychiatry , Oita University Faculty of Medicine , Hasama-Machi , Oita , Japan ;
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hirakawa
authors.affiliation: a Department of Neuropsychiatry , Oita University Faculty of Medicine , Hasama-Machi , Oita , Japan ;
authors.forename: Jotaro
authors.initials: J
authors.lastname: Akiyoshi
authors.affiliation: a Department of Neuropsychiatry , Oita University Faculty of Medicine , Hasama-Machi , Oita , Japan ;
authors.forename: Masaaki
authors.initials: M
authors.lastname: Muronaga
authors.affiliation: a Department of Neuropsychiatry , Oita University Faculty of Medicine , Hasama-Machi , Oita , Japan ;
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tanaka
authors.affiliation: a Department of Neuropsychiatry , Oita University Faculty of Medicine , Hasama-Machi , Oita , Japan ;
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ishitobi
authors.affiliation: a Department of Neuropsychiatry , Oita University Faculty of Medicine , Hasama-Machi , Oita , Japan ;
authors.forename: Ayako
authors.initials: A
authors.lastname: Inoue
authors.affiliation: b Department of Applied Linguistics , Oita University Faculty of Medicine , Hasama-Machi , Oita , Japan ;
authors.forename: Harumi
authors.initials: H
authors.lastname: Oshita
authors.affiliation: a Department of Neuropsychiatry , Oita University Faculty of Medicine , Hasama-Machi , Oita , Japan ;
authors.forename: Saeko
authors.initials: S
authors.lastname: Aizawa
authors.affiliation: a Department of Neuropsychiatry , Oita University Faculty of Medicine , Hasama-Machi , Oita , Japan ;
authors.forename: Koji
authors.initials: K
authors.lastname: Masuda
authors.affiliation: a Department of Neuropsychiatry , Oita University Faculty of Medicine , Hasama-Machi , Oita , Japan ;
authors.forename: Haruka
authors.initials: H
authors.lastname: Higuma
authors.affiliation: a Department of Neuropsychiatry , Oita University Faculty of Medicine , Hasama-Machi , Oita , Japan ;
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kanehisa
authors.affiliation: a Department of Neuropsychiatry , Oita University Faculty of Medicine , Hasama-Machi , Oita , Japan ;
authors.forename: Taiga
authors.initials: T
authors.lastname: Ninomiya
authors.affiliation: c Kawano Neurosurgery Hospital , Mori-Machi , Oita , Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kawano
mesh_terms: D000339:Affect; D000679:Amygdala / Q000473:pathology*; D001007:Anxiety / Q000473:pathology; D003863:Depression / Q000473:pathology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D066128:Gray Matter / Q000473:pathology; D006801:Humans; D006984:Hypertrophy / Q000473:pathology; D008279:Magnetic Resonance Imaging; D059906:Neuroimaging; D020641:Polymorphism, Single Nucleotide; D017397:Prefrontal Cortex / Q000473:pathology*; D022021:Tacrolimus Binding Proteins / Q000235:genetics*
chemical_list: D022021:Tacrolimus Binding Proteins
keywords: Amygdala; FKBP5; POMS; genetic susceptibility; genetics; magnetic resonance imaging