title: Meta-analyses of four polymorphisms of lipoprotein lipase associated with the risk of Alzheimer's disease.
abstract: OBJECTIVE
  We evaluated the contributions of four polymorphisms of the lipoprotein lipase (LPL) gene to the risk of Alzheimer's disease (AD).
  
  
  METHODS
  Through a comprehensive literature search for genetic variants of LPL involved in AD association studies, we found four polymorphisms for the current meta-analyses. These polymorphisms were Asn291Ser(rs268), PvuII(rs285), HindIII(rs320) and Ser447Ter(rs328).
  
  
  RESULTS
  In total, eight studies with 5064 cases and 5016 controls were retrieved for the meta-analyses of the four genetic variants. The analyses showed that Asn291Ser(rs268) (OR=2.34, 95% CI=1.05-5.25, P=0.04), HindIII(rs320) (OR=1.44, 95% CI=1.17-1.78, P=0.0006), and Ser447Ter(rs328) (OR=0.80, 95% CI=0.66-0.98, P=0.03) were significantly associated with a risk of AD. No association was found between the PvuII(rs285) polymorphism and the risk of AD.
  
  
  CONCLUSIONS
  Our results showed that Asn291Ser(rs268), HindIII(rs320) and Ser447Ter(rs328) polymorphisms of LPL were associated with a risk of AD. Asn291Ser(rs268) and HindIII(rs320) were predisposing factors of AD, whereas Ser447Ter(rs328) showed a protective effect for AD.
authors.affiliation: Fourth Military Medical University, No. 169, Changle West Road, Xi'an 710032, Shaanxi Province, China. Electronic address: Cjhc17@163.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Ren
authors.affiliation: Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 160, Pujian Road, Shanghai 200127, China. Electronic address: axingr90@163.com.
authors.forename: Xingxing
authors.initials: X
authors.lastname: Ren
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D008071:Lipoprotein Lipase
keywords: Alzheimer's disease; Lipoprotein lipase; Single nucleotide polymorphism