title: Contribution of Alcoholic and Nonalcoholic Fatty Liver Disease to the Burden of Liver-Related Morbidity and Mortality.
abstract: Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are common causes of chronic liver disease. NAFLD is associated with obesity and metabolic syndrome whereas ALD is associated with excessive alcohol consumption. Both diseases can progress to cirrhosis, hepatocellular carcinoma, and liver-related death. A higher proportion of patients with NAFLD die from cardiovascular disorders than patients with ALD, whereas a higher proportion of patients with ALD die from liver disease. NAFLD and ALD each are associated with significant morbidity, impairment to health-related quality of life, and economic costs to society.
authors.affiliation: Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia; Beatty Liver and Obesity Program, Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia. Electronic address: zobair.younossi@inova.org.
authors.forename: Zobair
authors.initials: Z
authors.lastname: Younossi
authors.affiliation: Center for Outcomes Research in Liver Diseases, Washington, District of Columbia.
authors.forename: Linda
authors.initials: L
authors.lastname: Henry
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000401:mortality; D002318:Cardiovascular Diseases / Q000150:complications / Q000401:mortality; D002423:Cause of Death; D017281:Cost of Illness; D005235:Fatty Liver, Alcoholic / Q000150:complications / Q000401:mortality*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology / Q000401:mortality*; D008113:Liver Neoplasms / Q000209:etiology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000401:mortality*; D009765:Obesity / Q000150:complications / Q000401:mortality; D015995:Prevalence; D011788:Quality of Life
keywords: ALD; Mortality; NAFLD