title: Peptide-Decorated Dendrimers and Their Bioapplications.
abstract: Peptide-decorated dendrimers (PDDs) are a class of spherical, regular, branched polymers that are modified by peptides covalently attached to their surface. PDDs have been used as protein mimetics, novel biomaterials, and in a wide range of biomedical applications. Since their design and development in the late eighties, poly-l-lysine has been a preferred core structure for PDDs. However, numerous recent innovations in polymer synthesis and ligation chemistry have re-energized the field and led to the emergence of well-defined peptide dendrimers with more diverse core structures and functions. This Minireview highlights the development of PDDs driven by significantly improved ligation chemistry incorporating structurally well-defined peptides and the emerging use of PDDs in imaging and drug development.
authors.affiliation: Institute of Molecular Bioscience, The University of Queensland, 306 Carmody Road, St Lucia, QLD 4072, Australia.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wan
authors.affiliation: Institute of Molecular Bioscience, The University of Queensland, 306 Carmody Road, St Lucia, QLD 4072, Australia. p.alewood@imb.uq.edu.au.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Alewood
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D018014:Gene Transfer Techniques; D006801:Humans; D008958:Models, Molecular; D061848:Optical Imaging / Q000379:methods; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D011107:Polylysine / Q000138:chemical synthesis / Q000737:chemistry; D011877:Radionuclide Imaging / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D050091:Dendrimers; D004337:Drug Carriers; D010455:Peptides; D011107:Polylysine
keywords: conjugation chemistry; dendrimers; drug delivery; multivalency; peptides