title: Gout Prophylaxis Evaluated According to the 2012 American College of Rheumatology Guidelines: Analysis from the CORRONA Gout Registry.
abstract: To analyze prophylaxis using the CORRONA (COnsortium of Rheumatology Researchers Of North America) Gout Registry according to the American College of Rheumatology (ACR) guidelines, and to evaluate whether differences in disease characteristics influenced prophylaxis.
  
  
  
  All patients with gout in the CORRONA Gout Registry between November 1, 2012, and November 26, 2013, were included. They were divided into 2 groups: "receiving prophylaxis" versus "not receiving prophylaxis" at the time of enrollment. Patients having a flare at time of visit were excluded. Descriptive statistics and multivariable logistic regression models were performed to evaluate the factors associated with prophylaxis.
  
  
  
  There were 1049 patients with gout available for analysis. There were 441 patients (42%) receiving prophylaxis and 608 (58%) not receiving prophylaxis. The most common drugs used for prophylaxis were colchicine (78%) and nonsteroidal antiinflammatory drugs (32%). Prophylaxis drug combination was used by 45 patients (10.2%). Patients in the "receiving prophylaxis" group were more likely to have a gout duration of ≤ 1 year (n = 68, p < 0.001), ≥ 1 flare in the year previous to enrollment (p < 0.001), ≥ 1 healthcare uses in the last year [Emergency Department (p = 0.029); outpatient visit to primary care, rheumatologist, or urgent care clinic (p < 0.001)], have tophi (p < 0.001), report pain > 3 (p = 0.001), and have disease activity > 10 (p < 0.001) compared with patients in the "not receiving prophylaxis" group.
  
  
  
  Forty-two percent of patients with gout in the CORRONA Gout Registry were receiving prophylaxis. Prophylaxis was significantly more common in patients with a higher disease burden and activity, which is in agreement with the ACR guidelines. Our study highlights disease characteristics influencing prophylaxis and furthers our knowledge on current use of flare prophylaxis.
authors.affiliation: From the Division of Rheumatology, Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey; Corrona LLC, Southborough, Massachusetts; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas; Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, New York; the Center for Rheumatology, Albany Medical College, Albany, New York; Department of Orthopedics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.N. Schlesinger, MD, Professor of Medicine and Chief, Division of Rheumatology, Department of Medicine, Rutgers-Robert Wood Johnson Medical School; C.J. Etzel, PhD, Corrona LLC, and the Department of Epidemiology, University of Texas MD Anderson Cancer Center; J. Greenberg, MD, MPH, Associate Professor, Division of Rheumatology, Department of Medicine, New York University School of Medicine, and Corrona LLC; J. Kremer, MD, Director, the Center for Rheumatology, Albany Medical College; L.R. Harrold, MD, MPH, Associate Professor, Department of Orthopedics, University of Massachusetts Medical School. schlesna@rutgers.edu.
authors.forename: Naomi
authors.initials: N
authors.lastname: Schlesinger
authors.affiliation: From the Division of Rheumatology, Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey; Corrona LLC, Southborough, Massachusetts; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas; Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, New York; the Center for Rheumatology, Albany Medical College, Albany, New York; Department of Orthopedics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.N. Schlesinger, MD, Professor of Medicine and Chief, Division of Rheumatology, Department of Medicine, Rutgers-Robert Wood Johnson Medical School; C.J. Etzel, PhD, Corrona LLC, and the Department of Epidemiology, University of Texas MD Anderson Cancer Center; J. Greenberg, MD, MPH, Associate Professor, Division of Rheumatology, Department of Medicine, New York University School of Medicine, and Corrona LLC; J. Kremer, MD, Director, the Center for Rheumatology, Albany Medical College; L.R. Harrold, MD, MPH, Associate Professor, Department of Orthopedics, University of Massachusetts Medical School.
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Etzel
authors.affiliation: From the Division of Rheumatology, Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey; Corrona LLC, Southborough, Massachusetts; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas; Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, New York; the Center for Rheumatology, Albany Medical College, Albany, New York; Department of Orthopedics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.N. Schlesinger, MD, Professor of Medicine and Chief, Division of Rheumatology, Department of Medicine, Rutgers-Robert Wood Johnson Medical School; C.J. Etzel, PhD, Corrona LLC, and the Department of Epidemiology, University of Texas MD Anderson Cancer Center; J. Greenberg, MD, MPH, Associate Professor, Division of Rheumatology, Department of Medicine, New York University School of Medicine, and Corrona LLC; J. Kremer, MD, Director, the Center for Rheumatology, Albany Medical College; L.R. Harrold, MD, MPH, Associate Professor, Department of Orthopedics, University of Massachusetts Medical School.
authors.forename: Jeff
authors.initials: J
authors.lastname: Greenberg
authors.affiliation: From the Division of Rheumatology, Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey; Corrona LLC, Southborough, Massachusetts; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas; Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, New York; the Center for Rheumatology, Albany Medical College, Albany, New York; Department of Orthopedics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.N. Schlesinger, MD, Professor of Medicine and Chief, Division of Rheumatology, Department of Medicine, Rutgers-Robert Wood Johnson Medical School; C.J. Etzel, PhD, Corrona LLC, and the Department of Epidemiology, University of Texas MD Anderson Cancer Center; J. Greenberg, MD, MPH, Associate Professor, Division of Rheumatology, Department of Medicine, New York University School of Medicine, and Corrona LLC; J. Kremer, MD, Director, the Center for Rheumatology, Albany Medical College; L.R. Harrold, MD, MPH, Associate Professor, Department of Orthopedics, University of Massachusetts Medical School.
authors.forename: Joel
authors.initials: J
authors.lastname: Kremer
authors.affiliation: From the Division of Rheumatology, Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey; Corrona LLC, Southborough, Massachusetts; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas; Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, New York; the Center for Rheumatology, Albany Medical College, Albany, New York; Department of Orthopedics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.N. Schlesinger, MD, Professor of Medicine and Chief, Division of Rheumatology, Department of Medicine, Rutgers-Robert Wood Johnson Medical School; C.J. Etzel, PhD, Corrona LLC, and the Department of Epidemiology, University of Texas MD Anderson Cancer Center; J. Greenberg, MD, MPH, Associate Professor, Division of Rheumatology, Department of Medicine, New York University School of Medicine, and Corrona LLC; J. Kremer, MD, Director, the Center for Rheumatology, Albany Medical College; L.R. Harrold, MD, MPH, Associate Professor, Department of Orthopedics, University of Massachusetts Medical School.
authors.forename: Leslie R
authors.initials: LR
authors.lastname: Harrold
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003078:Colchicine / Q000627:therapeutic use*; D005260:Female; D006073:Gout / Q000517:prevention & control*; D006074:Gout Suppressants / Q000627:therapeutic use*; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012042:Registries; D012219:Rheumatology; D016896:Treatment Outcome; D014481:United States
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006074:Gout Suppressants; D003078:Colchicine
keywords: FLARE PROPHYLAXIS; GOUT