title: Disrupted Intrinsic Local Synchronization in Poststroke Aphasia.
abstract: Evidence has accumulated from the task-related and task-free (i.e., resting state) studies that alternations of intrinsic neural networks exist in poststroke aphasia (PSA) patients. However, information is lacking on the changes in the local synchronization of spontaneous functional magnetic resonance imaging blood-oxygen level-dependent fluctuations in PSA at rest. We investigated the altered intrinsic local synchronization using regional homogeneity (ReHo) on PSA (n = 17) and age- and sex-matched healthy controls (HCs) (n = 20). We examined the correlations between the abnormal ReHo values and the aphasia severity and language performance in PSA. Compared with HCs, the PSA patients exhibited decreased intrinsic local synchronization in the right lingual gyrus, the left calcarine, the left cuneus, the left superior frontal gyrus (SFG), and the left medial of SFG. The local synchronization (ReHo value) in the left medial of SFG was positively correlated with aphasia severity (r = 0.55, P = 0.027) and the naming scores of Aphasia Battery of Chinese (r = 0.66, P = 0.005). This result is consistent with the important role of this value in language processing even in the resting state. The pathogenesis of PSA may be attributed to abnormal intrinsic local synchronous in multiple brain regions.
authors.affiliation: From the Center for Information in BioMedicine (MY, JL, DY, HC), Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, and Department of Stomatology (MY), the Fourth People's Hospital of Chengdu, Chengdu, China.
authors.forename: Mi
authors.initials: M
authors.lastname: Yang
authors.forename: Jiao
authors.initials: J
authors.lastname: Li
authors.forename: Dezhong
authors.initials: D
authors.lastname: Yao
authors.forename: Huafu
authors.initials: H
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D001037:Aphasia / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000503:physiopathology*; D012189:Retrospective Studies; D020521:Stroke / Q000150:complications*