title: Serum Leptin and Adiponectin Concentration in Type 2 Diabetes Patients in the Short and Long Term Following Biliopancreatic Diversion.
abstract: A deranged adipokine system is implicated in obesity and in type 2 diabetes mellitus (T2DM), and the lack of remission of T2DM after bariatric surgery could be also accounted for by the postoperative persistence of this condition.
  
  
  
  Thirty T2DM patients undergoing biliopancreatic diversion (BPD) with a wide range of baseline body mass index (BMI) were evaluated prior to and at 1 and 5 years following BPD. Besides the usual clinical evaluations, acute insulin response (AIR) to intravenous glucose load as a parameter of insulin secretion and the serum leptin and adiponectin concentration were measured throughout the follow-up period in all patients.
  
  
  
  A long-term T2DM remission was observed in 21 patients (70 %). Serum leptin level reduced at the first year and remained substantially unchanged at a long term in both the remitter and non-remitter patients, while following the operation, a progressive significant increase of serum adiponectin level was observed only in remitter patients (from 9.2 to 12.3 μg/mL at 1 year and to 15.18 μg/mL at 5 years in the remitters and from 8.8 to 8.75 μg/mL at 1 year and to 11.8 μg/mL at 5 years in the non-remitters). Serum leptin mean values were positively associated with the BMI ones both prior to and following BPD (p < 0.005), while serum adiponectin values were positively related (p < 0.04) to the postoperative AIR data.
  
  
  
  The improvement of the pattern of cytokine production, as evidenced by postoperative rise in serum adiponectin concentration, might play a role in T2DM remission after bariatric surgery.
authors.affiliation: Department of Internal Medicine, University of Genova, Azienda Ospedaliera Universitaria San Martino, Largo Benzi 8, 16132, Genova, Italy. adami@unige.it.
authors.forename: Gian Franco
authors.initials: GF
authors.lastname: Adami
authors.affiliation: Department of Clinical Nutrition, University of Genova, Azienda Ospedaliera Universitaria San Martino, Genova, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Gradaschi
authors.affiliation: Department of Internal Medicine, University of Genova, Azienda Ospedaliera Universitaria San Martino, Largo Benzi 8, 16132, Genova, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Andraghetti
authors.affiliation: Department of Surgery, University of Genova, Azienda Ospedaliera Universitaria San Martino, Genova, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Scopinaro
authors.affiliation: Department of Internal Medicine, University of Genova, Azienda Ospedaliera Universitaria San Martino, Largo Benzi 8, 16132, Genova, Italy.
authors.forename: Renzo
authors.initials: R
authors.lastname: Cordera
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D015904:Biliopancreatic Diversion; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000601:surgery*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000601:surgery; D011184:Postoperative Period; D013997:Time Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin
keywords: Acute insulin response; Adiponectin; Bariatric surgery; Leptin; Type 2 diabetes