title: Dysregulation of ion fluxes in bipolar affective disorder.
abstract: Bipolar disorder has attracted numerous research from different neurobiological angles. This review will summarize selected findings focusing on the role of disturbed transmem-braneous ion fluxes. Several mood stabilizers exhibit a distinct profile including effects on sodium, calcium and potassium conductance. In summary, some decisive mechanisms of action as calcium antagonism and modulation of potassium currents may play a crucial role in the success of any given mood stabilizer in bipolar disorder.
authors.affiliation: 1Department of Psychiatry,LMU München,Germany.
authors.forename: H C
authors.initials: HC
authors.lastname: Grunze
authors.affiliation: 2Department of Psychiatry,University of Freiburg,Freiburg,Germany.
authors.forename: J
authors.initials: J
authors.lastname: Langosch
authors.affiliation: 2Department of Psychiatry,University of Freiburg,Freiburg,Germany.
authors.forename: C
authors.initials: C
authors.lastname: Normann
authors.affiliation: 1Department of Psychiatry,LMU München,Germany.
authors.forename: D
authors.initials: D
authors.lastname: Rujescu
authors.affiliation: 1Department of Psychiatry,LMU München,Germany.
authors.forename: B
authors.initials: B
authors.lastname: Amann
authors.affiliation: 2Department of Psychiatry,University of Freiburg,Freiburg,Germany.
authors.forename: J
authors.initials: J
authors.lastname: Waiden