title: Health-promoting and disease-preventive potential of Trianthema portulacastrum Linn. (Gadabani) -An Indian medicinal and dietary plant.
abstract: It is estimated that 80% of the world population depends on traditional medicine for primary healthcare need. Trianthema portulacastrum Linn. (family: Aizoaceae) is a small perennial weed found in the Americas, Africa, India, and other regions of the world. This plant is used extensively in Indian traditional medicines and is also consumed as a vegetable throughout Asia for its perceived health benefits. Phytochemical analysis of T. portulacastrum reveals the presence of alkaloids, flavonoids, terpenoids, saponins, and phenolic compounds. Emerging studies demonstrate that crude extracts as well as bioactive phytoconstituents of T. portulacastrum exhibit potent antioxidant, anti-infective, analgesic, and anti-inflammatory activities. A growing number of in vitro and in vivo studies demonstrate various biological and pharmacological activities, including prevention and amelioration of hepatotoxicity, nephrotoxicity, hyperglycemia, hyperlipidemia, infectious diseases and cancer. This review aims to present and analyze available literature to understand the full potential of T. portulacastrum in health promotion and disease prevention. Current limitations and future directions of research on this medicinal and dietary plant are also critically discussed.
authors.affiliation: Department of Pharmacy Practice, School of Pharmacy, Chapman University, Irvine, CA 92618, USA.|Hoag Memorial Hospital Presbyterian, Newport Beach, CA 92663, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Yamaki
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, Miami, FL 33169, USA.
authors.forename: Kalyan C
authors.initials: KC
authors.lastname: Nagulapalli Venkata
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
authors.forename: Animesh
authors.initials: A
authors.lastname: Mandal
authors.affiliation: School of Health Sciences, University of Turabo, Gurabo, PR 00778, USA.
authors.forename: Piyali
authors.initials: P
authors.lastname: Bhattacharyya
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, Miami, FL 33169, USA.
authors.forename: Anupam
authors.initials: A
authors.lastname: Bishayee
mesh_terms: D035722:Aizoaceae / Q000737:chemistry; D006293:Health Promotion; D006801:Humans; D007194:India; D009753:Nutritive Value; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D010945:Plants, Edible; D010946:Plants, Medicinal
chemical_list: D010936:Plant Extracts