title: Diversely Substituted Quinolines via Rhodium-Catalyzed Alkyne Hydroacylation.
abstract: The Rh-catalyzed hydroacylative union of aldehydes and o-alkynyl anilines leads to 2-aminophenyl enones, and onward to substituted quinolines. The mild reaction conditions employed in this chemistry result in a process that displays broad functional group tolerance, allowing the preparation of diversely substituted quinolines in high yields. Extension to the use of o-alkynyl nitro arenes as substrates leads to 2-nitrochalcones, from which both quinolines and quinoline N-oxides can be accessed.
authors.affiliation: Department of Chemistry, University of Oxford, Chemistry Research Laboratory , Mansfield Road, Oxford, OX1 3TA, U.K.
authors.forename: James D
authors.initials: JD
authors.lastname: Neuhaus
authors.affiliation: Department of Chemistry, University of Oxford, Chemistry Research Laboratory , Mansfield Road, Oxford, OX1 3TA, U.K.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Morrow
authors.affiliation: Lilly Research Centre, Eli Lilly and Company Ltd., Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, U.K.
authors.forename: Michael
authors.initials: M
authors.lastname: Brunavs
authors.affiliation: Department of Chemistry, University of Oxford, Chemistry Research Laboratory , Mansfield Road, Oxford, OX1 3TA, U.K.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Willis