title: Total synthesis of protosappanin A and its derivatives via palladium catalyzed ortho C-H activation/C-C cyclization under microwave irradiation.
abstract: A total synthesis method for protosappanin A, which is a complex natural product with many biological activities, was developed with 6 linear steps. Dibenzo[b,d]oxepinones as the key intermediates of the synthetic route were prepared by a palladium-catalyzed ortho C-H activation/C-C cyclization under microwave irradiation. 25 derivatives of protosappanin A were obtained.
authors.affiliation: Key Laboratory of Chemical Engineering Process & Technology for High-efficiency Conversion, College of Chemistry and Materials Science, Heilongjiang University, Harbin, Heilongjiang 150080, P. R. China. wenyichu@hlju.edu.cn sunzz@hlju.edu.cn.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Liu
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhou
authors.forename: Chenglong
authors.initials: C
authors.lastname: Wang
authors.forename: Wanyong
authors.initials: W
authors.lastname: Fu
authors.forename: Wenyi
authors.initials: W
authors.lastname: Chu
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Sun