title: Smaller Width of the Pancreatic Duct During Secretin-Enhanced Magnetic Resonance Cholangiopancreatography in Pancreatic-Sufficient Cystic Fibrosis Patients.
abstract: New tools are needed in cystic fibrosis (CF) diagnostics in pancreatic-sufficient CF (PS-CF) patients. Secretin-enhanced magnetic resonance cholangiopancreatography (SE-MRCP) allows for improved assessment of the width of the pancreatic duct.
  
  
  
  Sixteen PS-CF patients and 17 healthy volunteers underwent SE-MRCP. The width of the pancreatic duct in the head, the body, and the tail of the pancreas was measured at the baseline and 1, 2, 3, 5, and 10 minutes after secretin administration.
  
  
  
  The width of the pancreatic duct in the head of the pancreas did not differ between the groups at the baseline; after 10 minutes of secretin stimulation, it was smaller in PS-CF patients (median, 1.4 mm [first-third quartile, 1.3-2.0] vs 2.2 mm [1.7-2.4], P = 0.008). The area under the curve for discrimination between the 2 groups using this parameter was 0.77 (95% confidence interval, 0.60-0.93).
  
  
  
  The SE-MRCP identified differences in the width of the pancreatic duct between PS-CF and healthy volunteers. Further improvements of the method are needed to augment its clinical utility.
authors.affiliation: From the Departments of *Pediatric Radiology, †Pediatric Gastroenterology and Metabolic Diseases, ‡Physiology, §General Radiology, and ∥Department of Computer Science and Statistics, Poznań University of Medical Sciences, Poznań, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jonczyk-Potoczna
authors.forename: Jan Krzysztof
authors.initials: JK
authors.lastname: Nowak
authors.forename: Edyta
authors.initials: E
authors.lastname: Madry
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Katulska
authors.forename: Sylwia
authors.initials: S
authors.lastname: Stezowska-Kubiak
authors.forename: Jerzy
authors.initials: J
authors.lastname: Moczko
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Lisowska
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Walkowiak
mesh_terms: D049448:Cholangiopancreatography, Magnetic Resonance; D003550:Cystic Fibrosis; D006801:Humans; D010179:Pancreas; D010183:Pancreatic Ducts; D012633:Secretin
chemical_list: D012633:Secretin