title: Functional nanomaterials for near-infrared-triggered cancer therapy.
abstract: The near-infrared (NIR) region (700-1100 nm) is the so-called transparency "therapeutic window" for biological applications owing to its deeper tissue penetration and minimal damage to healthy tissues. In recent years, various NIR-based therapeutic and interventional strategies, such as NIR-triggered drug delivery, photothermal therapy (PTT) and photodynamic therapy (PDT), are under research in intensive preclinical and clinical investigations for cancer treatment. The NIR control in these cancer therapy systems is considered crucial to boost local effective tumor suppression while minimizing side effects, resulting in improved therapeutic efficacy. Some researchers even predict the NIR-triggered cancer therapy to be a new and exciting possibility for clinical nanomedicine applications. In this review, the rapid development of NIR light-responsive cancer therapy based on various smartly designed nanocomposites for deep tumor treatments is introduced. In detail, the use of NIR-sensitive materials for chemotherapy, PTT as well as PDT is highlighted, and the associated challenges and potential solutions are discussed. The applications of NIR-sensitive cancer therapy modalities summarized here can highlight their potential use as promising nanoagents for deep tumor therapy.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. jlin@ciac.ac.cn cxli@ciac.ac.cn.
authors.forename: Bei
authors.initials: B
authors.lastname: Liu
authors.forename: Chunxia
authors.initials: C
authors.lastname: Li
authors.forename: Ziyong
authors.initials: Z
authors.lastname: Cheng
authors.forename: Zhiyao
authors.initials: Z
authors.lastname: Hou
authors.forename: Shanshan
authors.initials: S
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D004358:Drug Therapy; D006801:Humans; D051379:Mice; D053761:Nanocomposites / Q000032:analysis / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D050997:Nanomedicine; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D017319:Photosensitizing Agents