title: Extratemporal abnormalities in phosphorus magnetic resonance spectroscopy of patients with mesial temporal sclerosis.
abstract: OBJECTIVE
  We evaluated extratemporal metabolic changes with phosphorus magnetic resonance spectroscopy (31P-MRS) in patients with unilateral mesial temporal sclerosis (MTS).
  
  
  METHODS
  31P-MRS of 33 patients with unilateral MTS was compared with 31 controls. The voxels were selected in the anterior, posterior insula-basal ganglia (AIBG, PIBG) and frontal lobes (FL). Relative values of phosphodiesters- PDE, phosphomonoesters-PME, inorganic phosphate - Pi, phosphocreatine- PCr, total adenosine triphosphate [ATPt = γ- + a- + b-ATP] and the ratios PCr/ATPt, PCr/γ-ATP, PCr/Pi and PME/PDE were obtained.
  
  
  RESULTS
  We found energetic abnormalities in the MTS patients compared to the controls with Pi reduction bilaterally in the AIBG and ipsilaterally in the PIBG and the contralateral FL; there was also decreased PCr/γ-ATP in the ipsilateral AIBG and PIBG. Increased ATPT in the contralateral AIBG and increased γ-ATP in the ipsilateral PIBG were detected.
  
  
  CONCLUSIONS
  Widespread energy dysfunction was detected in patients with unilateral MTS.
authors.affiliation: Departamento de Radiologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Park
authors.affiliation: Departamento de Radiologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Maria Concepción Garcia
authors.initials: MC
authors.lastname: Otaduy
authors.affiliation: Departamento de Radiologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Katarina Paz
authors.initials: KP
authors.lastname: de Lyra
authors.affiliation: Departamento de Radiologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Celi Santos
authors.initials: CS
authors.lastname: Andrade
authors.affiliation: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Luiz Henrique Martins
authors.initials: LH
authors.lastname: Castro
authors.affiliation: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Valmir
authors.initials: V
authors.lastname: Passarelli
authors.affiliation: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Rosa Maria Figueiredo
authors.initials: RM
authors.lastname: Valerio
authors.affiliation: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Carmen Lisa
authors.initials: CL
authors.lastname: Jorge
authors.affiliation: Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brazil.
authors.forename: Miriam Harumi
authors.initials: MH
authors.lastname: Tsunemi
authors.affiliation: Departamento de Radiologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Claudia da Costa
authors.initials: Cda C
authors.lastname: Leite
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000378:metabolism*; D012598:Sclerosis / Q000175:diagnosis / Q000378:metabolism; D013702:Temporal Lobe / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult
chemical_list: D010758:Phosphorus