title: [Brain injury after induction chemotherapy in children with acute lymphoblastic leukemia].
abstract: OBJECTIVE
  To investigate the changes in brain injury after the induction chemotherapy in children with acute lymphoblastic leukemia (ALL) by cranial MRI.
  
  
  METHODS
  The clinical data and cranial MRI results of 62 children with ALL who were hospitalized from March 2014 to June 2015 were analyzed retrospectively.
  
  
  RESULTS
  Before chemotherapy, MRI showed bone marrow infiltration of the skull in 33 patients (53%); the children with WBC<20×10(9)/Lhad a significantly lower incidence rate of bone marrow infiltration of the skull than those with WBC≥20×10(9)/L (16 patients/42% vs 17 patients/71%; P<0.05), and the high-risk group had a significantly higher incidence rate of bone marrow infiltration of the skull than the non-high-risk group (71% vs 44%; P<0.05). Before chemotherapy, there were 4 cases (7%) of brain atrophy, and 2 cases (3%) of abnormal signals in the sensory conduction bundle. MRI reexamination in 28 patients after 3 months of chemotherapy showed 3 new cases (11%) of brain atrophy and 1 aggravated case of brain atrophy.
  
  
  CONCLUSIONS
  The children with ALL have bone marrow infiltration of the skull, brain atrophy, and abnormal signals in the sensory conduction bundle before chemotherapy, especially bone marrow infiltration of the skull, and some changes in brain injury disappear after treatment.
authors.affiliation: Department of Neurology, Shenzhen Children's Hospital of Chongqing Medical University, Shenzhen, Guangdong 518038, China. fwen62@126.com.
authors.forename: Dong-Fang
authors.initials: DF
authors.lastname: Zou
authors.forename: Hong-Wu
authors.initials: HW
authors.lastname: Zeng
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
authors.forename: Hui-Rong
authors.initials: HR
authors.lastname: Mai
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Yuan
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Wang
authors.forename: Jian-Xiang
authors.initials: JX
authors.lastname: Liao
authors.forename: Fei-Qiu
authors.initials: FQ
authors.lastname: Wen
mesh_terms: D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy / Q000009:adverse effects*; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000473:pathology; D012189:Retrospective Studies; D012886:Skull / Q000473:pathology