title: Targeting Tumor Cells by Natural Anti-Carbohydrate Antibodies Using Rhamnose-Functionalized Liposomes.
abstract: Recruitment of antibodies in human immune systems for targeted destruction of tumor cells has emerged as an exciting area of research due to its low occurrence of side effects, high efficacy, and high specificity. The presence of large amounts of anticarbohydrate natural antibodies in human sera has prompted research efforts to utilize carbohydrate epitopes for immune recruitment. Here, we have developed a general strategy for specific targeted destruction of tumor cells based on rhamnose-functionalized liposomes. Tumor cells artificially decorated with rhamnose epitopes were subjected to complement-mediated cytotoxicity in vitro and showed delayed tumor growth in vivo. This study highlights the therapeutic potential for activation of endogenous immune response through cell-surface glycan engineering.
authors.affiliation: Institute of Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou 310058, China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Hangzhou 310003, China.
authors.forename: Xuexia
authors.initials: X
authors.lastname: Li
authors.affiliation: Institute of Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou 310058, China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Hangzhou 310003, China.
authors.forename: Xiongjian
authors.initials: X
authors.lastname: Rao
authors.affiliation: Division of Mathematics and Science, University of South Carolina Salkehatchie , Walterboro, South Carolina 29488, United States.
authors.forename: Li
authors.initials: L
authors.lastname: Cai
authors.affiliation: Institute of Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou 310058, China.
authors.forename: Xuling
authors.initials: X
authors.lastname: Liu
authors.affiliation: Institute of Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou 310058, China.
authors.forename: Huixia
authors.initials: H
authors.lastname: Wang
authors.affiliation: Institute of Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou 310058, China.
authors.forename: Weinan
authors.initials: W
authors.lastname: Wu
authors.affiliation: Institute of Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou 310058, China.
authors.forename: Chenggang
authors.initials: C
authors.lastname: Zhu
authors.affiliation: School of Life Science and the State Key Laboratory of Microbial Technology, Shandong University , Jinan 250100, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: School of Life Science and the State Key Laboratory of Microbial Technology, Shandong University , Jinan 250100, China.|Department of Chemistry, Georgia State University , Atlanta, Georgia 30303, United States.
authors.forename: Peng G
authors.initials: PG
authors.lastname: Wang
authors.affiliation: Institute of Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou 310058, China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Hangzhou 310003, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Yi
mesh_terms: D000072283:A549 Cells; D000818:Animals; D000906:Antibodies / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D000939:Epitopes / Q000276:immunology; D005260:Female; D006367:HeLa Cells; D006801:Humans; D007167:Immunotherapy; D008081:Liposomes / Q000276:immunology / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D012210:Rhamnose / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D000906:Antibodies; D000939:Epitopes; D008081:Liposomes; D003165:Complement System Proteins; D012210:Rhamnose