title: Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087.
abstract: Seven sesquiterpene derivatives, including chaetopenoids A-F and dendryphiellin A1, and 6-methyl-(2E, 4E, 6S) octadienoic acid were isolated from the culture broth of Chaetoconis sp. FT087. Their structures were determined through the analysis of HRMS and NMR spectroscopic data. The absolute configurations of chaetopenoids A-D were elucidated by comparison of their CD and optical rotation data with those in the literature. Chaetopenoids A-C and E belong to the eremophilane type of sesquiterpenoids, while chaetopenoids D and F and dendryphiellin A1 have a trinor-eremophilane skeleton. All compounds were tested against A2780 and cisplatin resistant A2780CisR cell lines, and dendryphiellin A1 was moderately active with IC50 values of 6.6 and 9.1 μg/mL, respectively.
authors.affiliation: Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA; Natural Products and Experimental Therapeutics, Cancer Center, University of Hawai'i, 701 Ilalo Street, Honolulu, HI 96813, USA.
authors.forename: Chun-Shun
authors.initials: CS
authors.lastname: Li
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Natural Products and Experimental Therapeutics, Cancer Center, University of Hawai'i, 701 Ilalo Street, Honolulu, HI 96813, USA.
authors.forename: Bao-Jun
authors.initials: BJ
authors.lastname: Yang
authors.affiliation: Honolulu Botanical Garden, 50 N. Vineyard Blvd., Honolulu, HI 96817, USA.
authors.forename: Naomi
authors.initials: N
authors.lastname: Hoffman
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Yin
authors.affiliation: College of Pharmacy, Oregon State University, Corvallis, OR 97331-3507, USA.
authors.forename: Taifo
authors.initials: T
authors.lastname: Mahmud
authors.affiliation: Natural Products and Experimental Therapeutics, Cancer Center, University of Hawai'i, 701 Ilalo Street, Honolulu, HI 96813, USA.
authors.forename: James
authors.initials: J
authors.lastname: Turkson
authors.affiliation: Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA; Natural Products and Experimental Therapeutics, Cancer Center, University of Hawai'i, 701 Ilalo Street, Honolulu, HI 96813, USA. Electronic address: scao@hawaii.edu.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D006254:Hawaii; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: C000610698:6-methyl-(2E,4E,6S)octadienoic acid; D012717:Sesquiterpenes; C000610792:dendryphiellin A1
keywords: Araliaceae; Bioactivity; Chaetoconis sp. FT087; Endophytic fungi; Hawai’i; Osmoxylon novoguineensis; Sesquiterpenes