title: When the endothelium scores an own goal: endothelial cells actively augment metastatic extravasation through endothelial-mesenchymal transition.
abstract: Endothelial-mesenchymal transition (EndMT) is an important mechanism during organ development and in certain pathological conditions. For example, EndMT contributes to myofibroblast formation during organ fibrosis, and it has been identified as an important source of cancer-associated fibroblasts, facilitating tumor progression. Recently, EndMT was proposed to modulate endothelial function during intravasation and extravasation of metastatic tumor cells. Evidence suggests that endothelial cells are not passive actors during transendothelial migration (TEM) of cancer cells, as there are profound changes in endothelial junctional protein expression, signaling, permeability, and contractility. This review describes these alterations in endothelial characteristics during TEM of metastatic tumor cells and discusses them in the context of EndMT. EndMT could play an important role during metastatic intravasation and extravasation, a novel hypothesis that may lead to new therapeutic approaches to tackle metastatic disease.
authors.affiliation: Department of Pathophysiology, Semmelweis University, Budapest, Hungary;
authors.forename: Ákos
authors.initials: Á
authors.lastname: Gasparics
authors.affiliation: Department of Pathophysiology, Semmelweis University, Budapest, Hungary; Pediatrics and Nephrology Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary;
authors.forename: László
authors.initials: L
authors.lastname: Rosivall
authors.affiliation: Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary; Institute of Life Sciences, Vasile Goldis Western University of Arad, Arad, Romania; and.
authors.forename: István A
authors.initials: IA
authors.lastname: Krizbai
authors.affiliation: Department of Pathophysiology, Semmelweis University, Budapest, Hungary; Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany sebe.attila@med.semmelweis-univ.hu.
authors.forename: Attila
authors.initials: A
authors.lastname: Sebe
mesh_terms: D000818:Animals; D002450:Cell Communication; D042783:Endothelial Cells / Q000378:metabolism / Q000473:pathology*; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction; D057705:Transendothelial and Transepithelial Migration; D059016:Tumor Microenvironment
keywords: endothelial-mesenchymal transition; metastatic extravasation; transendothelial migration