title: Vitamin D and Lung Function Decline in Adults With Asthma: The HUNT Study.
abstract: We investigated whether low 25-hydroxyvitamin D (25(OH)D) levels were associated with more lung function decline in adults with asthma and whether this association was modified by smoking status or inhaled corticosteroid (ICS) use. We analyzed data on 395 adults with asthma from the Nord-Trøndelag Health Study (1995-2008), Norway. Plasma 25(OH)D and lung function were measured at baseline, and lung function measurements were repeated at follow-up, approximately 11 years later. Linear regression was used to estimate lung function decline. Participants with low 25(OH)D (<50 nmol/L) had more decline in lung function measurements for forced expiratory volume in 1 second (FEV1) (388 mL), forced vital capacity (298 mL), and the FEV1/forced vital capacity ratio (3.7%) over the follow-up, compared with those with high 25(OH)D (≥50 nmol/L) who declined 314 mL, 246 mL, and 3.0%, respectively (P = 0.08, 0.30, and 0.23, respectively). The associations were stronger in never smokers and non-ICS users. In never smokers, low 25(OH)D levels were associated with more decline in FEV1 (445 vs. 222 mL) (P = 0.01). In non-ICS users, low 25(OH)D levels were associated with more decline in FEV1 (467 vs. 320 mL) (P = 0.02). Low serum 25(OH)D levels were weakly associated with more lung function decline in adults with asthma, and stronger associations were observed in never smokers and non-ICS users.
authors.forename: Ben Michael
authors.initials: BM
authors.lastname: Brumpton
authors.forename: Arnulf
authors.initials: A
authors.lastname: Langhammer
authors.forename: Anne Hildur
authors.initials: AH
authors.lastname: Henriksen
authors.forename: Carlos Arturo
authors.initials: CA
authors.lastname: Camargo
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.forename: Pål Richard
authors.initials: PR
authors.lastname: Romundstad
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Mai
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000627:therapeutic use; D000328:Adult; D001249:Asthma / Q000097:blood / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006306:Health Surveys; D006801:Humans; D016014:Linear Models; D008168:Lung / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D009664:Norway; D011446:Prospective Studies; D012907:Smoking / Q000009:adverse effects*; D013147:Spirometry; D014797:Vital Capacity / Q000502:physiology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood / Q000502:physiology
chemical_list: D000305:Adrenal Cortex Hormones; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25-hydroxyvitamin D; asthma; lung function; spirometry; vitamin D