title: Adenovirus related lymphohistiocytic hemophagocytosis: Case report and literature review.
abstract: BACKGROUND
  Adenoviral infection is a classic cause of lymphohistiocytic hemophagocytosis (LH) in bone marrow transplantation but is rare outside this setting.
  
  
  METHODS
  A 31-year-old female, with a history of treated mesencephalic astrocytoma, was hospitalized for fever, pancytopenia, elevated liver enzymes, hyperferritinemia and hypertriglyceridemia. Adenovirus viral load in blood was 7.3×10(9) copies/mL. Bone marrow aspirate examination confirmed LH. The patient recovered without specific LH or adenovirus-directed treatment.
  
  
  CONCLUSIONS
  Adenovirus-related LH, common in bone marrow transplant recipients, should also be considered in patients with chemotherapy in solid tumors.
authors.affiliation: Service des maladies infectieuses et tropicales, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France. Electronic address: guillaume.mellon@aphp.fr.
authors.forename: G
authors.initials: G
authors.lastname: Mellon
authors.affiliation: Service des maladies infectieuses et tropicales, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, France.
authors.forename: B
authors.initials: B
authors.lastname: Henry
authors.affiliation: Antenne Médicale de Colmar, Centre Médical des armées de Strasbourg, 2 rue des Belges BP, 30446, Colmar, France.
authors.forename: O
authors.initials: O
authors.lastname: Aoun
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, France; Service de virologie, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Boutolleau
authors.affiliation: Service des maladies infectieuses et tropicales, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Laparra
authors.affiliation: Service de pneumologie et réanimation médicale, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Mayaux
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, France; Service de neurologie 2, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Sanson
authors.affiliation: Service des maladies infectieuses et tropicales, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, France.
authors.forename: E
authors.initials: E
authors.lastname: Caumes
mesh_terms: D000257:Adenoviridae Infections / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D000260:Adenoviruses, Human / Q000302:isolation & purification; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001254:Astrocytoma / Q000150:complications / Q000188:drug therapy; D001769:Blood / Q000821:virology; D001853:Bone Marrow / Q000473:pathology; D020295:Brain Stem Neoplasms / Q000150:complications / Q000188:drug therapy; D004358:Drug Therapy / Q000379:methods; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology* / Q000473:pathology*; D019562:Viral Load
chemical_list: D000970:Antineoplastic Agents
keywords: Adenovirus; Astrocytoma; Lymphohistiocytic hemophagocytosis