title: Tumor-derived factors modulating dendritic cell function.
abstract: Dendritic cells (DC) play unique and diverse roles in the tumor occurrence, development, progression and response to therapy. First of all, DC can actively uptake tumor-associated antigens, process them and present antigenic peptides to T cells inducing and maintaining tumor-specific T cell responses. DC interaction with different immune effector cells may also support innate antitumor immunity, as well as humoral responses also known to inhibit tumor development in certain cases. On the other hand, DC are recruited to the tumor site by specific tumor-derived and stroma-derived factors, which may also impair DC maturation, differentiation and function, thus resulting in the deficient formation of antitumor immune response or development of DC-mediated tolerance and immune suppression. Identification of DC-stimulating and DC-suppressing/polarizing factors in the tumor environment and the mechanism of DC modulation are important for designing effective DC-based vaccines and for recovery of immunodeficient resident DC responsible for maintenance of clinically relevant antitumor immunity in patients with cancer. DC-targeting tumor-derived factors and their effects on resident and administered DC in the tumor milieu are described and discussed in this review.
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Scaife Hall S735, 3550 Terrace Street, Pittsburgh, PA, 15261, USA.|Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao City, China.
authors.forename: Jinbao
authors.initials: J
authors.lastname: Zong
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Scaife Hall S735, 3550 Terrace Street, Pittsburgh, PA, 15261, USA.
authors.forename: Anton A
authors.initials: AA
authors.lastname: Keskinov
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Scaife Hall S735, 3550 Terrace Street, Pittsburgh, PA, 15261, USA.
authors.forename: Galina V
authors.initials: GV
authors.lastname: Shurin
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Scaife Hall S735, 3550 Terrace Street, Pittsburgh, PA, 15261, USA. shurinmr@upmc.edu.|Department of Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. shurinmr@upmc.edu.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Shurin
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000276:immunology*
keywords: Cytokines; Dendritic cells; Immunosuppression; Regulatory dendritic cells; Tolerance; Tumor immunoenvironment