title: Roles for RNA-binding proteins in development and disease.
abstract: RNA-binding protein activities are highly regulated through protein levels, intracellular localization, and post-translation modifications. During development, mRNA processing of specific gene sets is regulated through manipulation of functional RNA-binding protein activities. The impact of altered RNA-binding protein activities also affects human diseases in which there are either a gain-of-function or loss-of-function causes pathogenesis. We will discuss RNA-binding proteins and their normal developmental RNA metabolism and contrast how their function is disrupted in disease. This article is part of a Special Issue entitled SI:RNA Metabolism in Disease.
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Brinegar
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pathology and Immunology and Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: tcooper@bcm.edu.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Cooper
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism; D000067879:CELF1 Protein / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D048788:Growth and Development; D006321:Heart / Q000254:growth & development; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009223:Myotonic Dystrophy / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D034702:RNA-Binding Protein FUS / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D000067879:CELF1 Protein; D004268:DNA-Binding Proteins; C000599550:FUS protein, human; C493663:MBNL1 protein, human; D012333:RNA, Messenger; D034702:RNA-Binding Protein FUS; D016601:RNA-Binding Proteins; C000598624:TARDBP protein, human; D012313:RNA
keywords: Development; Neurodegenerative disease; Protein aggregate; Protein mis-regulation; RNA processing; RNA-binding protein