title: [PARTICIPATION OF NO-ERGIC MECHANISMS IN REALIZATION OF RESPIRATORY EFFECTS OF PRO-INFLAMMATORY CYTOKINE INTERLEUKIN-1-BETA].
abstract: The role of NO-ergic mechanisms in the realization of the respiratory effects of pro-inflammatory cytokine IL-1beta was investigated in acute experiments on anesthetized rats. To achieve this, we studied the effect of intravenous administration of IL-1beta during inhibition of NO-synthase by N-nitro-L-arginine methyl ester (L-NAME, a non-specific blocker of NO-synthase) on the parameters of breathing and the Hering-Breuer inspiratory-inhibitory reflex. It was shown that the effect of L-NAME eliminates the IL-1beta-dependent increase of the Hering-Breuer reflex, whereas effects on breathing pattern does not change: the increase in IL-1beta system-level evokes an increase in respiratory rate, tidal volume and lung ventilation. It is assumed that one of the mechanisms of enhance in the strength inspiratory-inhibitory reflex by increasing circulatory IL-1beta level is the increased glutamate-ergic transmission on pump-neurons induced by increase in nitric oxide synthesis in cerebrovascular endothelial cells. In conclusion, NO-ergic mechanisms participate in the modulation of the vagal respiratory reflexes during the development of the acute phase of systemic inflammation.
authors.forename: V G
authors.initials: VG
authors.lastname: Aleksandrov
authors.forename: N P
authors.initials: NP
authors.lastname: Aleksandrova
authors.forename: T S
authors.initials: TS
authors.lastname: Tumanova
authors.forename: A D
authors.initials: AD
authors.lastname: Evseeva
authors.forename: V A
authors.initials: VA
authors.lastname: Merkuriev
mesh_terms: D000818:Animals; D053583:Interleukin-1beta / Q000378:metabolism*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D012018:Reflex / Q000502:physiology*; D012119:Respiration
chemical_list: C000594089:IL1B protein, rat; D053583:Interleukin-1beta; D009569:Nitric Oxide; D019331:NG-Nitroarginine Methyl Ester