title: Long-term outcomes of radical vaginal trachelectomy and laparoscopic pelvic lymphadenectomy after neoadjuvant chemotherapy for the IB1 cervical cancer: A series of 60 cases.
abstract: OBJECTIVE
  The present study sought to analyze the long-time clinical outcomes of the stage IB1 cervical cancer patients who had received the radical vaginal trachelectomy (RVT) and laparoscopic lymphadenectomy after neoadjuvant chemotherapy (NACT).
  
  
  METHODS
  This is a prospective study of 60 patients potentially selected for RVT for a clinical and radiologic cervical cancer (stages IB 1) less than 2 cm. These patients were treated with surgery combined with preoperative NACT in the Department of Obstetrics and Gynecology, PLA General Hospital. We collected the patients' general clinical information, surgical characteristics and obstetric data, and then assessed their long-term oncological outcomes.
  
  
  RESULTS
  The average operative time of the enrolled cases was 204 min and the average blood loss was 443 mL. The average postoperative hospitalization time was 10.6 days. The postoperative pathologic results indicated that the average parametrical width was 1.99 cm; the average length of removed of cervical was 2.6 cm; the average number of excised pelvic lymph node was 20. The median of the follow-up was 43 months (range between 13month and 12 years). Only one case of recurrence was found. Thus far, totally 42 women had tried to conceive, and 36 of them had live births. The live birth pregnancy rate was 86% (36/42).
  
  
  CONCLUSIONS
  The radical vaginal trachelectomy in combination with the laparoscopic lymphadenectomy surgical is a safe and effective therapeutic strategy for the for IB 1 cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Hainan Branch of PLA General Hospital, Sanya, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Obstetrics, The General Hospital of Jinan Military Command, Jinan, PR China; Department of Obstetrics and Gynecology, PLA General Hospital, Beijing, PR China.
authors.forename: Zhongyu
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, PLA General Hospital, Beijing, PR China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Fu
authors.affiliation: Department of Obstetrics and Gynecology, Huabei Oil Field General Hospital, Hebei, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, Hainan Branch of PLA General Hospital, Sanya, PR China.
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Che
authors.affiliation: Department of Obstetrics and Gynecology, Hainan Branch of PLA General Hospital, Sanya, PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Mo
authors.affiliation: Department of Obstetrics and Gynecology, PLA General Hospital, Beijing, PR China. Electronic address: songlei301@aliyun.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Song
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy; D008197:Lymph Node Excision / Q000379:methods*; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D020360:Neoadjuvant Therapy / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D010388:Pelvis / Q000601:surgery; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D000069339:Trachelectomy / Q000379:methods*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D014621:Vagina / Q000601:surgery; D055815:Young Adult
keywords: Early-stage cervical cancer; Fertility-preserving surgery; Neoadjuvant chemotherapy; Radical vaginal trachelectomy