title: Dynamic gene expression profiles during postnatal development of porcine subcutaneous adipose.
abstract: A better understanding of the control of lipogenesis is of critical importance for both human and animal physiology. This requires a better knowledge of the changes of gene expression during the process of adipose tissue development. Thus, the objective of the current study was to determine the effects of development on subcutaneous adipose tissue gene expression in growing and adult pigs. Here, we present a comprehensive investigation of mRNA transcriptomes in porcine subcutaneous adipose tissue across four developmental stages using digital gene expression profiling. We identified 3,274 differential expressed genes associated with oxidative stress, immune processes, apoptosis, energy metabolism, insulin stimulus, cell cycle, angiogenesis and translation. A set of universally abundant genes (ATP8, COX2, COX3, ND1, ND2, SCD and TUBA1B) was found across all four developmental stages. This set of genes may play important roles in lipogenesis and development. We also identified development-related gene expression patterns that are linked to the different adipose phenotypes. We showed that genes enriched in significantly up-regulated profiles were associated with phosphorylation and angiogenesis. In contrast, genes enriched in significantly down-regulated profiles were related to cell cycle and cytoskeleton organization, suggesting an important role for these biological processes in adipose growth and development. These results provide a resource for studying adipose development and promote the pig as a model organism for researching the development of human obesity, as well as being used in the pig industry.
authors.affiliation: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.|Department of Animal Science, Southwest University at Rongchang, Chongqing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
authors.forename: Jideng
authors.initials: J
authors.lastname: Ma
authors.affiliation: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
authors.forename: Keren
authors.initials: K
authors.lastname: Long
authors.affiliation: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
authors.forename: Long
authors.initials: L
authors.lastname: Jin
authors.affiliation: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
authors.forename: Yihui
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.|Department of Aquaculture, Southwest University at Rongchang, Chongqing, China.
authors.forename: Chaowei
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Novogene Bioinformatics Institute, Beijing, China.
authors.forename: Shilin
authors.initials: S
authors.lastname: Tian
authors.affiliation: Chongqing Academy of Animal Science, Chongqing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Animal Science, Southwest University at Rongchang, Chongqing, China.|Chongqing Academy of Animal Science, Chongqing, China.
authors.forename: Zonggang
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
authors.forename: Qianzi
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
authors.forename: An'an
authors.initials: A
authors.lastname: Jiang
authors.affiliation: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Wang
authors.affiliation: Novogene Bioinformatics Institute, Beijing, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Wang
authors.affiliation: Novogene Bioinformatics Institute, Beijing, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Chongqing Academy of Animal Science, Chongqing, China.
authors.forename: Jinyong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
authors.forename: Xuewei
authors.initials: X
authors.lastname: Li
authors.affiliation: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
authors.forename: Mingzhou
authors.initials: M
authors.lastname: Li
keywords: Development; Gene expression; Pig; Subcutaneous adipose