title: Metabolomics and Its Application to Acute Lung Diseases.
abstract: Metabolomics is a rapidly expanding field of systems biology that is gaining significant attention in many areas of biomedical research. Also known as metabonomics, it comprises the analysis of all small molecules or metabolites that are present within an organism or a specific compartment of the body. Metabolite detection and quantification provide a valuable addition to genomics and proteomics and give unique insights into metabolic changes that occur in tangent to alterations in gene and protein activity that are associated with disease. As a novel approach to understanding disease, metabolomics provides a "snapshot" in time of all metabolites present in a biological sample such as whole blood, plasma, serum, urine, and many other specimens that may be obtained from either patients or experimental models. In this article, we review the burgeoning field of metabolomics in its application to acute lung diseases, specifically pneumonia and acute respiratory disease syndrome (ARDS). We also discuss the potential applications of metabolomics for monitoring exposure to aerosolized environmental toxins. Recent reports have suggested that metabolomics analysis using nuclear magnetic resonance (NMR) and mass spectrometry (MS) approaches may provide clinicians with the opportunity to identify new biomarkers that may predict progression to more severe disease, such as sepsis, which kills many patients each year. In addition, metabolomics may provide more detailed phenotyping of patient heterogeneity, which is needed to achieve the goal of precision medicine. However, although several experimental and clinical metabolomics studies have been conducted assessing the application of the science to acute lung diseases, only incremental progress has been made. Specifically, little is known about the metabolic phenotypes of these illnesses. These data are needed to substantiate metabolomics biomarker credentials so that clinicians can employ them for clinical decision-making and investigators can use them to design clinical trials.
authors.affiliation: Department of Clinical Pharmacy, College of Pharmacy, University of Michigan , Ann Arbor, MI , USA.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Stringer
authors.affiliation: Department of Chemistry, University of Alberta , Edmonton, AB , Canada.
authors.forename: Ryan T
authors.initials: RT
authors.lastname: McKay
authors.affiliation: Department of Computational Medicine and Bioinformatics, School of Medicine, University of Michigan , Ann Arbor, MI , USA.
authors.forename: Alla
authors.initials: A
authors.lastname: Karnovsky
authors.affiliation: Department of Medicine, University of Alberta , Edmonton, AB , Canada.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Quémerais
authors.affiliation: Department of Medicine, University of Alberta , Edmonton, AB , Canada.
authors.forename: Paige
authors.initials: P
authors.lastname: Lacy
keywords: acute respiratory distress syndrome; biomarkers; environmental exposure; mass spectroscopy; metabolites; nuclear magnetic resonance; pneumonia; precision medicine