title: Multiple vertebral fractures in young man as first manifestation of systemic mastocytosis.
abstract: Systemic mastocytosis (SM) is a clonal disease of mast cell progenitors from the bone marrow. The clinical picture varies from asymptomatic forms (indolent) to a highly aggressive form with a very short (mast cell leukemia) survival. Between 28-34% of patients with SM are related to bone condition at the time of diagnosis and 16% have symptomatic fractures. The presentation of SM as clinical vertebral fractures in young men is rare. Here, we describe a case of established osteoporosis as the only manifestation of SM.
authors.affiliation: Servicio de Reumatología, Complejo Hospitalario Universitario de Badajoz, Hospital Perpetuo Socorro, Badajoz, España. Electronic address: mcarrascocubero@gmail.com.
authors.forename: Carmen
authors.initials: C
authors.lastname: Carrasco Cubero
authors.affiliation: Servicio de Reumatología, Hospital de Mérida, Mérida, España.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Chamizo Carmona
mesh_terms: D000328:Adult; D006801:Humans; D008159:Lumbar Vertebrae / Q000293:injuries*; D008297:Male; D034721:Mastocytosis, Systemic / Q000150:complications / Q000175:diagnosis*; D016103:Spinal Fractures / Q000209:etiology*; D013904:Thoracic Vertebrae / Q000293:injuries*
keywords: Fracturas vertebrales; Male osteoporosis; Mastocitosis sistémica; Osteoporosis del varón; Systemic mastocytosis; Vertebral fractures