title: Prognostic significance of CD169-positive lymph node sinus macrophages in patients with endometrial carcinoma.
abstract: Lymph node (LN) macrophages play critical roles in anti-tumor immunity, which develops via the activation of cytotoxic T cells (CTL) and NK cells. The present study aims to determine the prognostic significance of CD169(+) LN macrophages in patients with endometrial carcinoma (EC). The number of CD169(+) cells or the CD169(+) -to-CD68(+) macrophage ratio in regional LN (RLN), and the number of CD8(+) CTL or CD57(+) NK cells in tumor tissues were investigated by immunohistochemistry in paraffin-embedded tissue samples from 79 patients with EC. A high density of CD169(+) cells in the RLN of patients with EC was correlated with an early clinical stage or no LN metastasis. A high number of CD169(+) cells and a high CD169(+) -to-CD68(+) macrophage ratio were significantly associated with longer overall survival in EC. We also found that the density of CD169(+) macrophages was positively correlated with the number of CD8(+) CTL and CD57(+) NK cells that infiltrated into tumor tissues. A high density of CD57(+) cells in EC tissues was associated with a better prognosis, while a high density of CD8(+) cells was not linked to an altered prognosis. The present study showed that the density of CD169(+) macrophages in RLN was associated with an improved prognosis in EC patients. CD169(+) macrophages in RLN might represent a useful marker for assessing clinical prognoses and monitoring anti-tumor immunity in patients with EC.
authors.affiliation: Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ohnishi
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Munekage
authors.initials: M
authors.lastname: Yamaguchi
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Chimeddulam
authors.initials: C
authors.lastname: Erdenebaatar
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Saito
authors.affiliation: Department of Mother-Child Nursing, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Tashiro
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Katabuchi
authors.affiliation: Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Takeya
authors.affiliation: Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Komohara
mesh_terms: D015703:Antigens, CD / Q000032:analysis / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D016889:Endometrial Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism*; D009367:Neoplasm Staging; D011379:Prognosis; D063267:Sialic Acid Binding Ig-like Lectin 1 / Q000032:analysis / Q000378:metabolism*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D063267:Sialic Acid Binding Ig-like Lectin 1; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C571166:SIGLEC1 protein, human
keywords: CD169; NK cell; endometrial carcinoma; regional lymph node; sinus macrophage