title: Application of aziridinium ring opening for preparation of optically active diamine and triamine analogues: Highly efficient synthesis and evaluation of DTPA-based MRI contrast enhancement agents.
abstract: Ring opening of aziridinium ions with nitrogen nucleophiles was applied to the highly efficient synthesis of optically active vicinal diamines and diethylene triamine pentaacetic acid (DTPA) analogues as potential magnetic resonance imaging (MRI) contrast enhancement agents. The synthetic method features a column-free isolation of the regiospecific and stereospecific nucleophilic substitution products of enantiomerically enriched aziridinium ions in excellent yield.
authors.affiliation: Department of Chemistry, Illinois Institute of Technology, Chicago, IL, USA.
authors.forename: Xiang
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Chemistry, Illinois Institute of Technology, Chicago, IL, USA.
authors.forename: Yunwei
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Illinois Institute of Technology, Chicago, IL, USA.
authors.forename: Ningjie
authors.initials: N
authors.lastname: Wu
authors.affiliation: Department of Chemistry, Illinois Institute of Technology, Chicago, IL, USA.
authors.forename: Chi Soo
authors.initials: CS
authors.lastname: Kang
authors.affiliation: Department of Chemistry, Illinois Institute of Technology, Chicago, IL, USA.
authors.forename: Hyun A
authors.initials: HA
authors.lastname: Song
authors.affiliation: Department of Chemistry, Illinois Institute of Technology, Chicago, IL, USA.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Jin
authors.affiliation: Department of Chemistry, Illinois Institute of Technology, Chicago, IL, USA.
authors.forename: Yao
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Henry
authors.initials: H
authors.lastname: Bryant
authors.affiliation: Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Frank
authors.affiliation: Department of Chemistry, Illinois Institute of Technology, Chicago, IL, USA.
authors.forename: Hyun-Soon
authors.initials: HS
authors.lastname: Chong