title: The genetic equidistance phenomenon at the proteomic level.
abstract: The field of molecular evolution started with the alignment of a few protein sequences in the early 1960s. Among the first results found, the genetic equidistance result has turned out to be the most unexpected. It directly inspired the ad hoc universal molecular clock hypothesis that in turn inspired the neutral theory. Unfortunately, however, what is only a maximum distance phenomenon was mistakenly transformed into a mutation rate phenomenon and became known as such. Previous work studied a small set of selected proteins. We have performed proteome wide studies of 7 different sets of proteomes involving a total of 15 species. All 7 sets showed that within each set of 3 species the least complex species is approximately equidistant in average proteome wide identity to the two more complex ones. Thus, the genetic equidistance result is a universal phenomenon of maximum distance. There is a reality of constant albeit stepwise or discontinuous increase in complexity during evolution, the rate of which is what the original molecular clock hypothesis is really about. These results provide additional lines of evidence for the recently proposed maximum genetic diversity (MGD) hypothesis.
authors.affiliation: State Key Laboratory of Medical Genetics, School of Life Sciences, Xiangya Medical School, Central South University, 110 Xiangya Road, Changsha, Hunan 410078, China.
authors.forename: Denghui
authors.initials: D
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Medical Genetics, School of Life Sciences, Xiangya Medical School, Central South University, 110 Xiangya Road, Changsha, Hunan 410078, China. Electronic address: huangshi@sklmg.edu.cn.
authors.forename: Shi
authors.initials: S
authors.lastname: Huang
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D019143:Evolution, Molecular; D014644:Genetic Variation; D006801:Humans; D008957:Models, Genetic; D059645:Mutation Rate; D010802:Phylogeny; D011506:Proteins / Q000145:classification / Q000235:genetics*; D020543:Proteome / Q000145:classification / Q000235:genetics*; D040901:Proteomics / Q000379:methods*; D012984:Software; D013045:Species Specificity; D013997:Time Factors
chemical_list: D011506:Proteins; D020543:Proteome
keywords: Genetic equidistance; Maximum genetic diversity hypothesis (MGD); Molecular clock; Neutral theory; Overlap feature