title: Clinical Observation on Hemogram Variation of Allogeneic Donors from Chinese Population for Peripheral Hematopoietic Stem Cell Collection.
abstract: Peripheral blood stem cell (PBSC) collection has been increasingly more popular than bone marrow donation, but little side effects induced by hemogram variation of donors for PBSC collection were reported. The peripheral blood cells were counted pre- and post-collection of PBSC from 166 allogeneic-related donors. Donors' hemoglobin concentration decreased from 144.95 (±16.175) g/L to 139.12 (±13.684) g/L (P < 0.05) and platelet counts decreased from 234.51 (±60.925) × 10(9)/L to 93.00 (±28.439) × 10(9)/L (P < 0.001) after sequential PBSC collections. The anemia condition was weakly correlated (r = 0.297, P < 0.02) and the decrease of platelet counts was strongly correlated (r = 0.719, P < 0.001) to the blood cells in the collection products. The hemoglobin concentration decrease had no significant difference in all four age groups between pre- and post-collection (P ≥ 0.05), but was significantly decreased between pre-collection and post-first collection, post-second collection (P < 0.05 and P < 0.001) in all the body mass index (BMI) groups, among which the underweight group was highly decreased. Neither of the BMI groups nor age groups indicated any statistical difference on platelet counts (P > 0.05). A slight decrease of hemoglobin and a significant decrease of platelet counts occurred after sequential PBSC collection, which was tolerable for donors younger than 60 years old. The collection characteristic of underweight persons should be fine-tuned to ensure their safety. The platelet decrease was independent of ages or BMI values.
authors.affiliation: 1 Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University , Hangzhou, China .
authors.forename: Meng
authors.initials: M
authors.lastname: Zhou
authors.affiliation: 1 Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University , Hangzhou, China .
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: 1 Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University , Hangzhou, China .
authors.forename: Shanshan
authors.initials: S
authors.lastname: Ma
authors.affiliation: 1 Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University , Hangzhou, China .
authors.forename: De
authors.initials: D
authors.lastname: Zhou
authors.affiliation: 1 Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University , Hangzhou, China .
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: 1 Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University , Hangzhou, China .
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhu
authors.affiliation: 1 Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University , Hangzhou, China .
authors.forename: Lixia
authors.initials: L
authors.lastname: Zhu
authors.affiliation: 1 Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University , Hangzhou, China .
authors.forename: Xiudi
authors.initials: X
authors.lastname: Yang
authors.affiliation: 2 Bone Marrow Transplantation Center, the First Affiliated Hospital of Medical School of Zhejiang University , Hangzhou, China .
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: 2 Bone Marrow Transplantation Center, the First Affiliated Hospital of Medical School of Zhejiang University , Hangzhou, China .
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.affiliation: 1 Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University , Hangzhou, China .
authors.forename: Xiujin
authors.initials: X
authors.lastname: Ye
authors.affiliation: 1 Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University , Hangzhou, China .
authors.forename: Wanzhuo
authors.initials: W
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D044466:Asian People; D001772:Blood Cell Count; D015992:Body Mass Index; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006454:Hemoglobins; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072916:Peripheral Blood Stem Cells / Q000166:cytology*; D010976:Platelet Count; D013048:Specimen Handling / Q000379:methods*; D014019:Tissue Donors; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D006454:Hemoglobins