title: [Comparative dynamics of EEG parameters in elderly depressive patients during monotherapy and combined therapy].
abstract: OBJECTIVE
  To compare the changes in brain functional state in combined antidepressive treatment (venlafaxine plus cerebrolysin) vs. monotherapy with the same antidepressant in elderly depressive patients using quantitative EEG methods.
  
  
  METHODS
  Forty patients, aged 60-79 years, mean 67.1±5.7) were randomized to two groups. Patients of group 1 were treated with venlafaxine (4 weeks, in dose of 75-150 mg/day). Patients of group 2 were additionally treated with cerebrolysin (totally 20 i/v infusions during 4 weeks, 20.0 ml in 100 ml isotonic NaCl solution).
  
  
  CONCLUSIONS
  The significant improvement of clinical conditions was shown by the end of the treatment course using both clinical assessments and HAMD-17, CGI-S, CGI-I and MMSE scores in both groups. The combined treatment with venlafaxine and cerebrolysin in patients of group 2 led to more pronounced improvement of their brain functional state (seen as an increase of spectral power and normalization of frequency alpha band of parietal-occipital EEG) in comparison with patients of group 2 treated by the same antidepressant alone.
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: A F
authors.initials: AF
authors.lastname: Iznak
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: E V
authors.initials: EV
authors.lastname: Iznak
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: Ya B
authors.initials: YB
authors.lastname: Kalyn
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: T P
authors.initials: TP
authors.lastname: Safarova
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: V S
authors.initials: VS
authors.lastname: Sheshenin
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: S I
authors.initials: SI
authors.lastname: Gavrilova
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage / Q000627:therapeutic use; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D002985:Clinical Protocols; D003866:Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000069470:Venlafaxine Hydrochloride / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000596:Amino Acids; D018687:Antidepressive Agents, Second-Generation; C006952:cerebrolysin; D000069470:Venlafaxine Hydrochloride