title: [Effect of continuous hemofiltration on inflammatory mediators and hemodynamics in children with severe hand, foot and mouth disease].
abstract: OBJECTIVE
  To investigate the effect of continuous veno-venous hemofiltration (CVVH) on inflammatory mediators in children with severe hand, foot and mouth disease (HFMD), and to investigate its clinical efficacy.
  
  
  METHODS
  A total of 36 children with stage IV HFMD were enrolled and randomly divided into conventional treatment group and CVVH group (n=18 each). The children in the CVVH group were given CVVH for 48 hours in addition to the conventional treatment. The levels of interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and lactic acid in peripheral venous blood, heart rate, blood pressure, and left ventricular ejection fraction were measured before treatment and after 24 and 48 hours of treatment.
  
  
  RESULTS
  After 24 hours of treatment, the conventional treatment group had a significantly reduced serum IL-2 level (P<0.01), and the CVVH treatment group had significantly reduced serum levels of IL-2, IL-6, IL-10, and TNF-α (P<0.05). After 48 hours of treatment, both groups had significantly reduced serum levels of IL-2, IL-6, IL-10, and TNF-α (P<0.01), and the CVVH group had significantly lower levels of these inflammatory factors than the conventional treatment group (P<0.01). After 48 hours of treatment, heart rate, systolic pressure, and blood lactic acid level were significantly reduced, and left ventricular ejection fraction was significantly increased in both groups, and the CVVH group had significantly greater changes in these indices except systolic pressure than the conventional treatment group (P<0.01).
  
  
  CONCLUSIONS
  CVVH can effectively eliminate inflammatory factors, reduce heart rate and venous blood lactic acid, and improve heart function in children with severe HFMD.
authors.affiliation: Intensive Care Unit One, Children's Hospital of Hebei Province, Shijiazhuang 050031, China. xmin17909@126.com.
authors.forename: Li-Jing
authors.initials: LJ
authors.lastname: Cao
authors.forename: Wen-Jin
authors.initials: WJ
authors.lastname: Geng
authors.forename: Mei-Xian
authors.initials: MX
authors.lastname: Xu
authors.forename: Xi-Min
authors.initials: XM
authors.lastname: Huo
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Wang
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Shi
mesh_terms: D002675:Child, Preschool; D016207:Cytokines / Q000097:blood; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D006439:Hemodynamics; D006440:Hemofiltration; D006801:Humans; D007223:Infant; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D016277:Ventricular Function, Left
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators