title: A new benzofuran derivative from Nicotiana tabacum.
abstract: A new benzofuran derivative, methyl 3-acetyl-7-hydroxy-6-methoxy-2-methylbenzofuran-4-carboxylate (1), and a known compound pyrrolezanthine (2), were isolated from leaves of Nicotiana tabacum. Compound 1 was elucidated by means of spectroscopic methods, as well as X-ray diffraction. Both compounds 1 and 2 exhibited moderate inhibitory activities on human cancer cell lines.
authors.affiliation: a Technology Center , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650202 , China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Xia
authors.affiliation: a Technology Center , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650202 , China.
authors.forename: Yuan-Dong
authors.initials: YD
authors.lastname: Li
authors.affiliation: a Technology Center , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650202 , China.
authors.forename: Xiu-Ming
authors.initials: XM
authors.lastname: Liu
authors.affiliation: a Technology Center , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650202 , China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: a Technology Center , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650202 , China.
authors.forename: Yi-Qin
authors.initials: YQ
authors.lastname: Wu
authors.affiliation: a Technology Center , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650202 , China.
authors.forename: Yun-Hua
authors.initials: YH
authors.lastname: Qin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014026:Nicotiana / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D004365:Drugs, Chinese Herbal; D011758:Pyrroles; C000613130:methyl 3-acetyl-7-hydroxy-6-methoxy-2-methylbenzofuran-4-carboxylate; C473505:pyrrolezanthine
keywords: Nicotiana tabacum; benzofuran; cytotoxicity