title: Correlation of serum IgE levels and clinical manifestations in patients with actinic prurigo.
abstract: BACKGROUND
  Actinic prurigo is an idiopathic photodermatosis, the pathophysiology of which has been hypothesized to involve subtype IV type b (Th2) hypersensitive response, whereby IL4, IL5, and IL13 are secreted and mediate the production of B cells, IgE, and IgG4.
  
  
  OBJECTIVE
  To examine the association of serum IgE levels and the clinical severity of injuries.
  
  
  METHODS
  This case-control study comprised patients with a clinical and histopathological diagnosis of actinic prurigo, as well as clinically healthy subjects, from whom 3cc of peripheral blood was taken for immunoassay. Cases were classified by lesion severity as mild, moderate, and severe. Descriptive statistics were analyzed, and chi-square test was performed.
  
  
  RESULTS
  We included 21 actinic prurigo patients and 21 subjects without disease; 11 patients with actinic prurigo had elevated serum IgE levels, and 10 had low serum levels. Six actinic prurigo (AP) patients with elevated serum levels of IgE had moderate injuries, 4 had severe injuries, and 1 had minor injuries. Eight out of 10 patients with normal IgE levels presented with minor injuries in the clinical evaluation. The 21 controls did not have increased serum IgE levels.
  
  
  CONCLUSIONS
  Elevated IgE levels are associated with moderate to severe clinical lesions, suggesting that actinic prurigo entails a type IV subtype b hypersensitivity response in which Th2 cells predominate.
authors.affiliation: Juarez University of the State of Durango, Durango, Mexico.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Cuevas-Gonzalez
authors.affiliation: Dr. Manuel Gea González General Hospital, Mexico City, Mexico.
authors.forename: Zahide
authors.initials: Z
authors.lastname: Lievanos-Estrada
authors.affiliation: Dr. Manuel Gea González General Hospital, Mexico City, Mexico.
authors.forename: Maria Elisa
authors.initials: ME
authors.lastname: Vega-Memije
authors.affiliation: Dr. Manuel Gea González General Hospital, Mexico City, Mexico.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Hojyo-Tomoka
authors.affiliation: Dr. Manuel Gea González General Hospital, Mexico City, Mexico.
authors.forename: Luciano
authors.initials: L
authors.lastname: Dominguez-Soto
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007118:Immunoassay; D007073:Immunoglobulin E / Q000097:blood*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000097:blood* / Q000473:pathology / Q000503:physiopathology*; D012016:Reference Values; D012720:Severity of Illness Index; D012873:Skin Diseases, Genetic / Q000097:blood* / Q000473:pathology / Q000503:physiopathology*; D013792:Thalidomide / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D007073:Immunoglobulin E; D013792:Thalidomide