title: (68)Ga-DOTATATE PET in juvenile angiofibroma.
abstract: BACKGROUND
  As somatostatin receptors (SSTRs) may be overexpressed in rapidly growing vessels, the aim of this study was the analysis of in vivo and in vitro SSTR2A expression in juvenile angiofibroma (JA).
  
  
  METHODS
  A group of six male adolescents with a diagnosis of primary, recurrent/residual JA was enrolled in the study. All patients underwent (68)Ga-DOTATATE PET/computed tomography (CT) followed by immunohistochemical staining for SSTR expression.
  
  
  RESULTS
  (68)Ga-DOTATATE PET/CT showed accumulation in areas matching the pathologic tissue in the nasopharynx of all patients studied with SUVmax of 5.1 ± 0.9 (ranging from 3.6 to 6.4). In all cases, the immunohistochemical examination showed a presence of SSTR2A with a high staining index.
  
  
  CONCLUSIONS
  In vitro SSTR2A cytoplasm expression was found to be high in all tumor specimens. However, the uptake of (68)Ga-DOTATATE was weak in the PET/CT studies. We postulate that the intracellular localization of the SSTR2A in JA may cause this discrepancy.
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine & Dentistry, Medical University of Warsaw, 19/25 Stepinska Street, 00-739 Warsaw, Poland.
authors.forename: Zuzanna
authors.initials: Z
authors.lastname: Gronkiewicz
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine & Dentistry, Medical University of Warsaw, 19/25 Stepinska Street, 00-739 Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kukwa
authors.affiliation: Nuclear Medicine Department, Medical University of Warsaw, 1a Banacha Street, 02-097 Warsaw, Poland.
authors.forename: Leszek
authors.initials: L
authors.lastname: Krolicki
authors.affiliation: Department of Pathology, Medical University of Warsaw, 7 Pawinskiego Street, 02-106 Warsaw, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Cyran-Chlebicka
authors.affiliation: Radioisotope Centre POLATOM, National Centre for Nuclear Research, Otwock, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Pawlak
authors.affiliation: Department of Otolaryngology, Medical University of Gdansk, 7 Debinki Street, 80-952 Gdansk, Poland.
authors.forename: Czeslaw
authors.initials: C
authors.lastname: Stankiewicz
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine & Dentistry, Medical University of Warsaw, 19/25 Stepinska Street, 00-739 Warsaw, Poland.
authors.forename: Antoni
authors.initials: A
authors.lastname: Krzeski
authors.affiliation: Department of Pathology, Medical University of Warsaw, 7 Pawinskiego Street, 02-106 Warsaw, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Górnicka
authors.affiliation: Department of Pathology, Medical University of Warsaw, 7 Pawinskiego Street, 02-106 Warsaw, Poland.
authors.forename: Dominika
authors.initials: D
authors.lastname: Wolosz
authors.affiliation: Nuclear Medicine Department, Medical University of Warsaw, 1a Banacha Street, 02-097 Warsaw, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kunikowska
mesh_terms: D000293:Adolescent; D018322:Angiofibroma / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008297:Male; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin / Q000032:analysis*
chemical_list: D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; C513399:gallium Ga 68 dotatate; C093733:somatostatin receptor 2
keywords: 68Ga-DOTATATE PET/CT; head and neck; imaging; immunohistochemistry; juvenile angiofibroma; somatostatin receptor