title: Neutrophils: Critical components in experimental animal models of cancer.
abstract: Neutrophils have a crucial role in tumor development and metastatic progression. The contribution of neutrophils in tumor development is multifaceted and contradictory. On the one hand, neutrophils prompt tumor inception, promote tumor development by mediating the initial angiogenic switch and facilitate colonization of circulating tumor cells, and on the other hand, have cytotoxic and anti-metastatic capabilities. Our understanding of the role of neutrophils in tumor development has greatly depended on different experimental animal models of cancer. In this review we cover important findings that have been made about neutrophils in experimental animal models of cancer, point to their advantages and limitations, and discuss novel techniques that can be used to expand our knowledge of how neutrophils influence tumor progression.
authors.affiliation: University of California, San Francisco, Department of Anatomy, 513 Parnassus Avenue, HSW1320, San Francisco, CA 94143, USA. Electronic address: catharina.hagerling@ucsf.edu.
authors.forename: Catharina
authors.initials: C
authors.lastname: Hagerling
authors.affiliation: University of California, San Francisco, Department of Anatomy, 513 Parnassus Avenue, HSW1320, San Francisco, CA 94143, USA. Electronic address: zena.werb@ucsf.edu.
authors.forename: Zena
authors.initials: Z
authors.lastname: Werb
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D007113:Immunity, Innate; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000276:immunology / Q000378:metabolism; D020556:Neutrophil Infiltration / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D059016:Tumor Microenvironment / Q000276:immunology
keywords: Animal models; Neutrophil; Tumor development