title: [The Use of Synthetic Polymers (Superdisintegrants) in Technology Tablets Containing Ethanol Dry Extract from Asparagus officinalis].
abstract: BACKGROUND
  Dry extracts are now frequently used in medicine as an alternative to synthetic drugs. In the case of tablet technology with dry plant extracts, the proper selection of disintegrants (superdisintegrants) is particularly important. Objectives. The aim of this study was to evaluate the usefulness of the polymers constituting superdisintegrants (Vivasol®, Vivastar®, Polyplasdone XL) in uncoated tablet formulation of alcoholic extracted from Asparagus officinalis.
  
  
  METHODS
  Dry the ethanol extract of Asparagus officinalis, Vivasol®, Vivastar®, Vivapur®, Kollidon VA64, Polyplasdone XL, magnesium stearate. Direct compression. Paddle method was carried out to study pharmacopoeial parameters and pharmaceutical availability. The calculation of equivalency factors: similarity [f2] and the difference [f1]. Approximation results.
  
  
  RESULTS
  Tablets brownish-green, with a smooth and uniform surface, without stains, chipping and damage. The determined average weight of the tablets compiled with the standards. The test friability and crushing strength revealed that the most mechanically strong tablets contained Vivasol, Vivastar, Polyplasdone XL. These tablets also have a longer disintegration and dissolution time compared with tablets containing only Vivasol. These differences are also confirmed by the calculated f2 and f1.
  
  
  CONCLUSIONS
  The addition of a mixture of Polyplasdone XL and Vivastar to Vivasol significantly increases the mechanical strength of the tablets (crushing strength, resistance to crushing). The addition of a mixture of Polyplasdone XL and Vivastar to Vivasol paradoxically increases the disintegration time of tablets (11.1 min). Single superdisintegrant breaks up the tablet more effectively than a mixture of superdisintegrants.
authors.affiliation: Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.
authors.forename: Wojciech Andrzej
authors.initials: WA
authors.lastname: Linka
authors.affiliation: Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.
authors.forename: Ilona
authors.initials: I
authors.lastname: Wojtaszek
authors.affiliation: Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.
authors.forename: Marian Mikołaj
authors.initials: MM
authors.lastname: Zgoda
authors.affiliation: Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.
authors.forename: Michał Krzysztof
authors.initials: MK
authors.lastname: Kołodziejczyk
mesh_terms: D027761:Asparagus Plant; D002482:Cellulose; D005079:Excipients / Q000737:chemistry*; D055595:Mechanical Phenomena; D010936:Plant Extracts; D011205:Povidone; D011759:Pyrrolidines; D013607:Tablets / Q000737:chemistry*; D014753:Vinyl Compounds
chemical_list: D005079:Excipients; D010936:Plant Extracts; D011759:Pyrrolidines; D013607:Tablets; D014753:Vinyl Compounds; C402301:poly(vinylpyrrolidone-co-vinyl-acetate); C477445:vivapur; D002482:Cellulose; D011205:Povidone