title: Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function.
abstract: In cardiac tissue engineering approaches to treat myocardial infarction, cardiac cells are seeded within three-dimensional porous scaffolds to create functional cardiac patches. However, current cardiac patches do not allow for online monitoring and reporting of engineered-tissue performance, and do not interfere to deliver signals for patch activation or to enable its integration with the host. Here, we report an engineered cardiac patch that integrates cardiac cells with flexible, freestanding electronics and a 3D nanocomposite scaffold. The patch exhibited robust electronic properties, enabling the recording of cellular electrical activities and the on-demand provision of electrical stimulation for synchronizing cell contraction. We also show that electroactive polymers containing biological factors can be deposited on designated electrodes to release drugs in the patch microenvironment on demand. We expect that the integration of complex electronics within cardiac patches will eventually provide therapeutic control and regulation of cardiac function.
authors.affiliation: The Laboratory for Tissue Engineering and Regenerative Medicine, Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv 69978, Israel.|The Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Ron
authors.initials: R
authors.lastname: Feiner
authors.affiliation: The Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel.|Department of Materials Science and Engineering, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Leeya
authors.initials: L
authors.lastname: Engel
authors.affiliation: The Laboratory for Tissue Engineering and Regenerative Medicine, Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv 69978, Israel.|The Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Sharon
authors.initials: S
authors.lastname: Fleischer
authors.affiliation: The Laboratory for Tissue Engineering and Regenerative Medicine, Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv 69978, Israel.|Department of Materials Science and Engineering, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Maayan
authors.initials: M
authors.lastname: Malki
authors.affiliation: The Laboratory for Tissue Engineering and Regenerative Medicine, Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Idan
authors.initials: I
authors.lastname: Gal
authors.affiliation: The Laboratory for Tissue Engineering and Regenerative Medicine, Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Assaf
authors.initials: A
authors.lastname: Shapira
authors.affiliation: Department of Physical Electronics, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Yosi
authors.initials: Y
authors.lastname: Shacham-Diamand
authors.affiliation: The Laboratory for Tissue Engineering and Regenerative Medicine, Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv 69978, Israel.|The Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel.|Department of Materials Science and Engineering, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Tal
authors.initials: T
authors.lastname: Dvir
mesh_terms: D000818:Animals; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology; D053761:Nanocomposites / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*