title: Imaging of the Lamina Cribrosa using Swept-Source Optical Coherence Tomography.
abstract: The lamina cribrosa (LC) is the presumed site of axonal injury in glaucoma. Its deformation has been suggested to contribute to optic neuropathy by impeding axoplasmic flow within the optic nerve fibers, leading to apoptosis of retinal ganglion cells. To visualize the LC in vivo, optical coherence tomography (OCT) has been applied. Spectral domain (SD)-OCT, used in conjunction with recently introduced enhanced depth imaging (EDI)-OCT, has improved visualization of deeper ocular layers, but in many individuals it is still limited by inadequate resolution, poor image contrast and insufficient depth penetrance. The posterior laminar surface especially is not viewed clearly using these methods. New generation high-penetration (HP)-OCTs, also known as swept-source (SS)-OCT, are capable to evaluate the choroid in vivo to a remarkable level of detail. SS-OCTs use a longer wavelength (1,050 nm instead of 840 nm) compared to the conventional techniques. We review current knowledge of the LC, findings from trials that use SD-OCT and EDI-OCT, and our experience with a prototype SS-OCT to visualize the LC in its entirety. Key Points What is known? •     The LC is the presumed site of axonal injury in glaucoma •     Compared to spectral domain-OCT, enhanced depth imaging-OCT improves imaging of the LC •     Even so, currently used SD-OCT techniques are restricted by poor wavelength penetrance of the deeper ocular layers What our findings add? •    SS-OCT may be a superior imaging modality for deep ocular structures •    Prior studies used SS-OCT to evaluate choroidal thickness in both healthy and 'normal tension glaucoma' eyes •    SS-OCT enables good evaluation of three-dimension (3D) lamina cribrosa morphology. How to cite this article: Nuyen B, Mansouri K, Weinreb RN. Imaging of the Lamina Cribrosa using Swept-Source Optical Coherence Tomography. J Current Glau Prac 2012;6(3): 113-119.
authors.affiliation: Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Center, University of California, San Diego, La Jolla, California, USA.
authors.forename: Brenda
authors.initials: B
authors.lastname: Nuyen
authors.affiliation: Research Fellow, Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Center, University of California, San Diego, La Jolla, California, USA.
authors.forename: Kaweh
authors.initials: K
authors.lastname: Mansouri
authors.affiliation: Chairman, Department of Ophthalmology, Director, Hamilton Glaucoma Center and Shiley Eye Center, University of California, San Diego, La Jolla, California, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: N Weinreb
keywords: Glaucoma; Intraocular pressure; Swept-source optical coherence tomography.