title: First case of imported Zika virus infection in Spain.
abstract: We report a case of Zika virus (ZIKV) infection in a patient with diarrhea, fever, synovitis, non-purulent conjunctivitis, and with discreet retro-orbital pain, after returning from Colombia in January 2016. The patient referred several mosquito bites. Presence of ZIKV was detected by PCR (polymerase chain reaction) in plasma. Rapid microbiological diagnosis of ZIKV infection is needed in European countries with circulation of its vector, in order to avoid autochthonous circulation. The recent association of ZIKV infection with abortion and microcephaly, and a Guillain-Barré syndrome highlights the need for laboratory differentiation of ZIKV from other virus infection. Women with potential risk for Zika virus infection who are pregnant or planning to become pregnant must mention that fact during prenatal visits in order to be evaluated and properly monitored.
authors.affiliation: Internal Medicine, University Hospital Rio Hortega, Valladolid, Spain. Electronic address: pbachiller@gmail.com.
authors.forename: Pablo
authors.initials: P
authors.lastname: Bachiller-Luque
authors.affiliation: Microbiology, University Hospital Rio Hortega, Valladolid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Domínguez-Gil González
authors.affiliation: Emergency, University Hospital Rio Hortega, Valladolid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Álvarez-Manzanares
authors.affiliation: Virology Area (Arbovirus and Imported Viral Diseases), National Center for Microbiology, Institute Carlos III, Majadahonda, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Vázquez
authors.affiliation: Virology Area (Arbovirus and Imported Viral Diseases), National Center for Microbiology, Institute Carlos III, Majadahonda, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: De Ory
authors.affiliation: Virology Area (Arbovirus and Imported Viral Diseases), National Center for Microbiology, Institute Carlos III, Majadahonda, Madrid, Spain.
authors.forename: M Paz
authors.initials: MP
authors.lastname: Sánchez-Seco Fariñas
mesh_terms: D005060:Europe; D006801:Humans; D007299:Insect Bites and Stings / Q000821:virology*; D008297:Male; D008875:Middle Aged; D013030:Spain; D014195:Travel; D000071244:Zika Virus; D000071243:Zika Virus Infection / Q000175:diagnosis*
keywords: Aedes mosquitoes; Arbovirus; Enfermedades transmitidas por vectores; Flavivirus; Mosquitos Aedes; Vector-borne diseases; Virus Zika; Zika virus