title: Palladium-catalyzed enantioselective allylic alkylation of trifluoromethyl group substituted racemic and acyclic unsymmetrical 1,3-disubstituted allylic esters with malonate anions.
abstract: We examined the palladium-catalyzed allylic alkylation of trifluoromethyl group-substituted racemic and acyclic unsymmetrical 1,3-disubstituted allylic benzoate with a malonate anion, and succeeded in obtaining an enantiomerically enriched product in high yields with high ee values through the dynamic kinetic asymmetric transformation (DYKAT). The best result was attained by the [Pd(C3H5)(cod)]BF4/(S)-tol-BINAP in the presence of BSA or DMAP as a base.
authors.affiliation: Department of Chemistry, College of Humanities & Sciences, Nihon University, Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan. kawatsur@chs.nihon-u.ac.jp.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ikeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Futamura
authors.forename: Taisyun
authors.initials: T
authors.lastname: Hanakawa
authors.forename: Maki
authors.initials: M
authors.lastname: Minakawa
authors.forename: Motoi
authors.initials: M
authors.lastname: Kawatsura