title: The effect of intrathecal baclofen treatment on activities of daily life in children and young adults with cerebral palsy and progressive neurological disorders.
abstract: BACKGROUND
  Intrathecal baclofen (ITB) treatment is applied in patients with spastic cerebral palsy (SCP), dystonic cerebral palsy (DCP) and progressive neurological disease (PND). Our aim was to investigate whether ITB treatment has a different effect on activities of daily life (ADL) in these groups.
  
  
  METHODS
  A retrospective and cross-sectional survey was conducted using a questionnaire to assess the qualitative effect of ITB (Likert scale) on different domains of functioning (mobility, personal care, communication, comfort) and satisfaction with the results. Groups were compared using non-parametric statistics.
  
  
  RESULTS
  Questionnaires were completed for 68 patients (39 SCP, 13 DCP, 16 PND). Satisfaction scores were relatively high in all groups (7-8) and the positive effect on personal care and communication was similar in all groups. The PND group had the shortest follow-up and scored significantly less favourably for the effect on mobility and comfort.
  
  
  CONCLUSIONS
  This is the first study to show that ITB treatment has similar effects on personal care and communication in stable and progressive neurological disease. The decrease in mobility in the PND group is likely due to the progressive nature of the disease. The different effect on comfort between groups is mainly due to the smaller effect on startles in the PND group.
authors.affiliation: VU University Medical Center, Department of Rehabilitation Medicine, Postbus 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: l.bonouvrie@vumc.nl.
authors.forename: Laura
authors.initials: L
authors.lastname: Bonouvrié
authors.affiliation: VU University Medical Center, Department of Rehabilitation Medicine, Postbus 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: Jg.becher@vumc.nl.
authors.forename: Jules
authors.initials: J
authors.lastname: Becher
authors.affiliation: Maastricht University Medical Center+, Department of Neurology, Postbus 5800, 6202 AZ Maastricht, The Netherlands. Electronic address: D.soudant@mumc.nl.
authors.forename: Dan
authors.initials: D
authors.lastname: Soudant
authors.affiliation: VU University Medical Center, Department of Rehabilitation Medicine, Postbus 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: Ai.buizer@vumc.nl.
authors.forename: Annemieke
authors.initials: A
authors.lastname: Buizer
authors.affiliation: VU University Medical Center, Department of Neurosurgery, Postbus 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: W.vouwerkerk@vumc.nl.
authors.forename: Willem
authors.initials: W
authors.lastname: van Ouwerkerk
authors.affiliation: Maastricht University Medical Center+, Department of Orthopedic Surgery, Postbus 5800, 6202 AZ Maastricht, The Netherlands. Electronic address: J.vles@mumc.nl.
authors.forename: Georges
authors.initials: G
authors.lastname: Vles
authors.affiliation: Maastricht University Medical Center+, Department of Neurology, Postbus 5800, 6202 AZ Maastricht, The Netherlands. Electronic address: Jeroen.vermeulen@mumc.nl.
authors.forename: R Jeroen
authors.initials: RJ
authors.lastname: Vermeulen
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D001418:Baclofen / Q000008:administration & dosage / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000188:drug therapy*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000627:therapeutic use; D009128:Muscle Spasticity / Q000188:drug therapy*; D009422:Nervous System Diseases / Q000188:drug therapy*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen
keywords: Baclofen; Cerebral palsy; Child; Dystonia; Muscle spasticity; Nervous system diseases