title: [Role of octreotide and prednisolone in prophylactic of poshepatectomy liver failure. Experimental study].
abstract: OBJECTIVE
  Comparative morphologic assessment of the liver tissue response to the preoperative infusion of octreotide and prednisolon after the major hepatic resection was studied in rats.
  
  
  METHODS
  25 male Wistar rats weighing 230--280 g were used. All rats underwent 70--80% hepatectomy. The rats were divided into three groups according to the infusions before hepatectomy: group 1 (n=7) -- received octreotide, group 2 (n=8) -- prednisolone, group 3 (n=10) -- 0.9% saline solution as the control. Histologic features of the remnant liver were evaluated in the sacrificied rats after 72 hours post-hepatectomy.
  
  
  RESULTS
  In the group 1 we observed more rapid decrease of edema and tendency to the accelerated regeneration process of hepatocytes.
  
  
  CONCLUSIONS
  Octreotide infusion before the major hepatic resection may have protective effect on hepatocytes and accelerate the regeneration in the remnant liver.
authors.affiliation: Moscow Clinical Scientific Center; Department of Surgery, M.V. Lomonosov Moscow State University.
authors.forename: R B
authors.initials: RB
authors.lastname: Alikhanov
authors.affiliation: Department of Surgery, M.V. Lomonosov Moscow State University.
authors.forename: A V
authors.initials: AV
authors.lastname: Sorokina
authors.affiliation: Department of Surgery, Laboratory of Minimally Invasive Surgery.
authors.forename: F G
authors.initials: FG
authors.lastname: Zabozlaev
authors.affiliation: Institute of Clinical Surgery, Federal Research Clinical Center of Specialized Medical Care and Medical Technologies FMBA A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
authors.forename: D N
authors.initials: DN
authors.lastname: Panchenkov
authors.affiliation: Institute of Clinical Surgery, Federal Research Clinical Center of Specialized Medical Care and Medical Technologies FMBA A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Astakhov
mesh_terms: D000818:Animals; D018890:Chemoprevention / Q000379:methods; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005765:Gastrointestinal Agents / Q000008:administration & dosage; D006498:Hepatectomy / Q000009:adverse effects* / Q000379:methods; D008099:Liver / Q000187:drug effects / Q000473:pathology; D017093:Liver Failure / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D008115:Liver Regeneration / Q000187:drug effects; D008953:Models, Anatomic; D015282:Octreotide / Q000008:administration & dosage*; D011239:Prednisolone / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D011239:Prednisolone; D015282:Octreotide