title: Cerebral Venous Thrombosis with Migraine-Like Headache and the Trigeminovascular System.
abstract: Cerebral venous thrombosis- (CVT-) associated headache is considered a secondary headache, commonly presenting as intracranial hypertension headache in association with seizures and/or neurological signs. However, it can occasionally mimic migraine. We report a patient presenting with a migraine-like, CVT-related headache refractory to several medications but intravenous dihydroergotamine (DHE). The response to DHE, which is considered to be an antimigraine medication, in addition to the neurovascular nature of migraine, points out to a probable similarity between CVT-headache and migraine. Based on experimental studies, we discuss this similarity and hypothesize a trigeminovascular role in the genesis of CVT-associated headache.
authors.affiliation: Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.
authors.forename: Fábio A
authors.initials: FA
authors.lastname: Nascimento
authors.affiliation: Neurological Institute of Curitiba (INC), 300 Rua Jeremias Maciel Perretto, 81210-310 Curitiba, PR, Brazil.
authors.forename: Marília Grando
authors.initials: MG
authors.lastname: Sória
authors.affiliation: Neurological Institute of Curitiba (INC), 300 Rua Jeremias Maciel Perretto, 81210-310 Curitiba, PR, Brazil.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Rizelio
authors.affiliation: Neurological Institute of Curitiba (INC), 300 Rua Jeremias Maciel Perretto, 81210-310 Curitiba, PR, Brazil.
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Kowacs