title: Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.
abstract: Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.
authors.affiliation: Division of Epidemiology, Biostatistics and Preventive Medicine , University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Page
authors.affiliation: Department of Epidemiology and Biostatistics , University of California San Francisco.
authors.forename: Ali
authors.initials: A
authors.lastname: Mirzazadeh
authors.affiliation: Department of Epidemiology and Biostatistics , University of California San Francisco.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Rice
authors.affiliation: The Kirby Institute for Infection and Immunity in Society.
authors.forename: Jason
authors.initials: J
authors.lastname: Grebely
authors.affiliation: Harvard Medical School , Boston, Massachusetts.
authors.forename: Arthur Y
authors.initials: AY
authors.lastname: Kim
authors.affiliation: Department of Medicine , Johns Hopkins Medical Institutions , Baltimore, Maryland.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Cox
authors.affiliation: Department of Epidemiology and Biostatistics , University of California San Francisco.
authors.forename: Meghan D
authors.initials: MD
authors.lastname: Morris
authors.affiliation: Burnet Institute , Melbourne, Victoria , Australia.
authors.forename: Margaret
authors.initials: M
authors.lastname: Hellard
authors.affiliation: Centre Hospitalier de l'Université de Montréal , Quebec , Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Bruneau
authors.affiliation: Centre Hospitalier de l'Université de Montréal , Quebec , Canada.
authors.forename: Naglaa H
authors.initials: NH
authors.lastname: Shoukry
authors.affiliation: The Kirby Institute for Infection and Immunity in Society.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Dore
authors.affiliation: The Kirby Institute for Infection and Immunity in Society.
authors.forename: Lisa
authors.initials: L
authors.lastname: Maher
authors.affiliation: School of Medical Sciences , University of New South Wales , Sydney , Australia.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Lloyd
authors.affiliation: Harvard Medical School , Boston, Massachusetts.
authors.forename: Georg
authors.initials: G
authors.lastname: Lauer
authors.affiliation: GGD Public Health Service of Amsterdam , The Netherlands.
authors.forename: Maria
authors.initials: M
authors.lastname: Prins
authors.affiliation: Seres Therapeutics , Cambridge, Massachusetts.
authors.forename: Barbara H
authors.initials: BH
authors.lastname: McGovern
keywords: IFNL4; acute infection; alanine aminotransferase; hepatitis C virus; jaundice