title: Minocycline-induced orbital rim discoloration.
abstract: A 20-year-old woman underwent lacrimal gland biopsy for unilateral swelling and was unexpectedly found to have olive-green discoloration of her orbital rim. Postoperative questioning revealed that as a teenager she had been treated for acne with minocycline, a semisynthetic tetracycline antibiotic and a first-line treatment for moderate and severe acne. While hyperpigmentation is a known side effect of minocycline, reports of pigmentation changes of the periorbital bones are relatively rare and could pose a diagnostic dilemma during surgery.
authors.affiliation: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
authors.forename: Tiffany N S
authors.initials: TN
authors.lastname: Ballard
authors.affiliation: Department of Ophthalmology, University of Michigan, Ann Arbor, Michigan. Electronic address: cesarb@med.umich.edu.
authors.forename: César A
authors.initials: CA
authors.lastname: Briceño
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001706:Biopsy; D005260:Female; D006801:Humans; D007765:Lacrimal Apparatus / Q000473:pathology; D008911:Minocycline / Q000009:adverse effects*; D009916:Orbital Diseases / Q000139:chemically induced* / Q000175:diagnosis; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000175:diagnosis; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline