title: Overview of Genetically Engineered Mouse Models of Distinct Breast Cancer Subtypes.
abstract: Advances in the screening of new therapeutic options have significantly reduced the breast cancer death rate over the last decade. Despite these advances, breast cancer remains the second leading cause of cancer death among women. This is due in part to the complexity of the disease, which is characterized by multiple subtypes that are driven by different genetic mechanisms and that likely arise from different cell types of origin. Because these differences often drive treatment options and outcomes, it is important to select relevant preclinical model systems to study new therapeutic interventions and tumor biology. Described in this unit are the characteristics and applications of validated genetically engineered mouse models (GEMMs) of basal-like, luminal, and claudin-low human subtypes of breast cancer. These different subtypes have different clinical outcomes and require different treatment strategies. These GEMMs can be considered faithful surrogates of their human disease counterparts. They represent alternative preclinical tumor models to cell line and patient-derived xenografts for preclinical drug discovery and tumor biology studies.
authors.affiliation: Deptartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, N.C.
authors.forename: Jerry
authors.initials: J
authors.lastname: Usary
authors.affiliation: Deptartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, N.C.
authors.forename: David Brian
authors.initials: DB
authors.lastname: Darr
authors.affiliation: Deptartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, N.C.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Pfefferle
authors.affiliation: Deptartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, N.C.
authors.forename: Charles M
authors.initials: CM
authors.lastname: Perou
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D004195:Disease Models, Animal; D055808:Drug Discovery; D005260:Female; D006801:Humans
chemical_list: D000970:Antineoplastic Agents
keywords: breast cancer; drug testing; efficacy prediction; gene expression; mouse models