title: Healing at implants installed concurrently to maxillary sinus floor elevation with Bio-Oss®or autologous bone grafts. A histo-morphometric study in rabbits.
abstract: OBJECTIVE
  To compare the healing at elevated sinus floors augmented either with deproteinized bovine bone mineral (DBBM) or autologous bone grafts and followed by immediate implant installation.
  
  
  METHODS
  Twelve albino New Zealand rabbits were used. Incisions were performed along the midline of the nasal dorsum. The nasal bone was exposed. A circular bony widow with a diameter of 3 mm was prepared bilaterally, and the sinus mucosa was detached. Autologous bone (AB) grafts were collected from the tibia. Similar amounts of AB or DBBM granules were placed below the sinus mucosa. An implant with a moderately rough surface was installed into the elevated sinus bilaterally. The animals were sacrificed after 7 (n = 6) or 40 days (n = 6).
  
  
  RESULTS
  The dimensions of the elevated sinus space at the DBBM sites were maintained, while at the AB sites, a loss of 2/3 was observed between 7 and 40 days of healing. The implants showed similar degrees of osseointegration after 7 (7.1 ± 1.7%; 9.9 ± 4.5%) and 40 days (37.8 ± 15%; 36.0 ± 11.4%) at the DBBM and AB sites, respectively. Similar amounts of newly formed mineralized bone were found in the elevated space after 7 days at the DBBM (7.8 ± 6.6%) and AB (7.2 ± 6.0%) sites while, after 40 days, a higher percentage of bone was found at AB (56.7 ± 8.8%) compared to DBBM (40.3 ± 7.5%) sites.
  
  
  CONCLUSIONS
  Both Bio-Oss®granules and autologous bone grafts contributed to the healing at implants installed immediately in elevated sinus sites in rabbits. Bio-Oss®maintained the dimensions, while autologous bone sites lost 2/3 of the volume between the two periods of observation.
authors.affiliation: ARDEC, Ariminum Odontologica, Rimini, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: De Santis
authors.affiliation: Center for Dental Medicine, University of Zurich, Zurich, Switzerland.|University of Bern, Bern, Switzerland.
authors.forename: Niklaus P
authors.initials: NP
authors.lastname: Lang
authors.affiliation: Faculdade de Odontologia, UNESP - Universidade Estadual Paulista, Araçatuba (SP), Brazil.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Ferreira
authors.affiliation: Faculdade de Odontologia, UNESP - Universidade Estadual Paulista, Araçatuba (SP), Brazil.
authors.forename: Idelmo
authors.initials: I
authors.lastname: Rangel Garcia
authors.affiliation: ARDEC, Ariminum Odontologica, Rimini, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Caneva
authors.affiliation: ARDEC, Ariminum Odontologica, Rimini, Italy.|Faculdade de Odontologia, UNESP - Universidade Estadual Paulista, Araçatuba (SP), Brazil.|POI-Programa Odontológico Internacional, Cartagena de Indias, Bolivar, Colombia.
authors.forename: Daniele
authors.initials: D
authors.lastname: Botticelli
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D000069343:Bone-Implant Interface / Q000473:pathology; D003758:Dental Implantation, Endosseous / Q000379:methods*; D008903:Minerals / Q000627:therapeutic use*; D016348:Osseointegration; D011817:Rabbits; D059546:Sinus Floor Augmentation / Q000379:methods*; D013977:Tibia / Q000637:transplantation
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals
keywords: Schneiderian membrane; animal study; autologous bone graft; bone formation; bone healing; dental implants; deproteinized bovine bone mineral; histometry; lateral approach; morphometry; osseointegration; sinus floor elevation