title: Age-associated differences on structural brain MRI in nondemented individuals from 71 to 103 years.
abstract: Successful brain aging in the oldest old (≥90 years) is underexplored. This study examined cross-sectional brain morphological differences from 8th to 11th decades of life in nondemented individuals by high-resolution magnetic resonance imaging. Two hundred seventy-seven nondemented community-dwelling participants (71-103 years) from Sydney Memory and Ageing Study and Sydney Centenarian Study comprised the sample, including a subsample of 160 cognitively high-functioning elders. Relationships between age and magnetic resonance imaging-derived measurements were studied using general linear models; and structural profiles of the ≥90 years were delineated. In full sample and the subsample, significant linear negative relationship of gray matter with age was found, with the greatest age effects in the medial temporal lobe and parietal and occipital cortices. This pattern was further confirmed by comparing directly the ≥90 years to the 71-89 years groups. Significant quadratic age effects on total white matter and white matter hyperintensities were observed. Our study demonstrated heterogeneous differences across brain regions between the oldest old and young old, with an emphasis on hippocampus, temporoposterior cortex, and white matter hyperintensities.
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia.
authors.forename: Zixuan
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia.
authors.forename: Wei
authors.initials: W
authors.lastname: Wen
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia.
authors.forename: Jiyang
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia.
authors.forename: John D
authors.initials: JD
authors.lastname: Crawford
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia; Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Australia, Sydney, New South Wales, Australia.
authors.forename: Simone
authors.initials: S
authors.lastname: Reppermund
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia; Prince of Wales Clinical School, UNSW Australia, Sydney, New South Wales, Australia.
authors.forename: Charlene
authors.initials: C
authors.lastname: Levitan
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia.
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Slavin
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia.
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Kochan
authors.affiliation: School of Public Health and Community Medicine, UNSW Australia, Sydney, New South Wales, Australia.
authors.forename: Robyn L
authors.initials: RL
authors.lastname: Richmond
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia; Dementia Collaborative Research Centre-Assessment and Better Care (DCRC-ABC), School of Psychiatry, UNSW Australia, Sydney, New South Wales, Australia; Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Randwick, New South Wales, Australia.
authors.forename: Henry
authors.initials: H
authors.lastname: Brodaty
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia; Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Australia, Sydney, New South Wales, Australia.
authors.forename: Julian N
authors.initials: JN
authors.lastname: Trollor
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia. Electronic address: p.sachdev@unsw.edu.au.
authors.forename: Perminder S
authors.initials: PS
authors.lastname: Sachdev
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D066127:White Matter / Q000473:pathology
keywords: Brain aging; Gray matter; Hippocampus; Oldest old; Structural MRI; White matter hyperintensities