title: Transoral laser microsurgery as primary treatment for selected T3 glottic and supraglottic cancers.
abstract: T3 laryngeal cancer encompasses heterogeneous lesions whose treatment is still debated. The purpose of this study was to evaluate transoral laser microsurgery (TLM) in management of selected T3 glottic and supraglottic cancers.
  
  
  
  Fifty-six patients with selected T3 glottic and supraglottic squamous cell carcinomas (SCCs) treated by TLM ± selective neck dissection ± adjuvant therapy were evaluated in terms of overall survival (OS), disease-free survival (DFS), and organ preservation rates.
  
  
  
  For the entire cohort, 5-year OS and DFS were 63.3% and 72.4%, whereas they were 65.2% and 72.9% for glottic and 59.3% and 76.3% for supraglottic SCC, respectively. No patient required permanent tracheostomy and 1 patient was gastrostomy tube-dependent at last follow-up.
  
  
  
  TLM ± selective neck dissection ± adjuvant (chemo)radiotherapy for selected T3 glottic and supraglottic SCC represents an effective alternative treatment to open partial laryngectomies and nonsurgical organ preservation protocols, particularly in elderly and frail patients. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1107-1112, 2016.
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, University of Genoa, Genoa, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Peretti
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.
authors.forename: Cesare
authors.initials: C
authors.lastname: Piazza
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, University of Genoa, Genoa, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Penco
authors.affiliation: Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
authors.forename: Gregorio
authors.initials: G
authors.lastname: Santori
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Del Bon
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, University of Genoa, Genoa, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Garofolo
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Paderno
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, University of Genoa, Genoa, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Guastini
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Nicolai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery* / Q000628:therapy; D059186:Chemoradiotherapy, Adjuvant; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005931:Glottis / Q000473:pathology / Q000601:surgery; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery* / Q000628:therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery* / Q000628:therapy; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods; D060787:Neoplasm Grading; D059351:Organ Sparing Treatments / Q000379:methods; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: T3 category; glottic cancer; oncologic outcomes; supraglottic cancer; transoral laser microsurgery