title: Impact of Percutaneous Coronary Intervention for Chronic Total Occlusion in Non-Infarct-Related Arteries in Patients With Acute Myocardial Infarction (from the COREA-AMI Registry).
abstract: Chronic total occlusion (CTO) in a non-infarct-related artery (IRA) is an independent predictor of clinical outcomes in patients with acute myocardial infarction (AMI). This study evaluated the impact of successful percutaneous coronary intervention (PCI) for CTO of a non-IRA on the long-term clinical outcomes in patients with AMI. A total of 4,748 patients with AMI were consecutively enrolled in the Convergent Registry of Catholic and Chonnam University for AMI registry from January 2004 to December 2009. We enrolled 324 patients with CTO in a non-IRA. To adjust for baseline differences, propensity matching (96 matched pairs) was used to compare successful PCI and occluded CTO for the treatment of CTO in non-IRA. The primary clinical end points were all-cause mortality and a composite of the major adverse cardiac events, including cardiac death, MI, stroke, and any revascularization during the 5-year follow-up. Patients who received successful PCI for CTO of non-IRA had lower rates of all-cause mortality (16.7% vs 32.3%, hazard ratio 0.459, 95% CI 0.251 to 0.841, p = 0.012) and major adverse cardiac events (21.9% vs 55.2%, hazard ratio 0.311, 95% CI 0.187 to 0.516, p <0.001) compared with occluded CTO group. Subgroup analyses revealed that successful PCI resulted in a better mortality rate in patients with normal renal function compared to patients with chronic kidney disease (p = 0.010). In conclusion, successful PCI for CTO of non-IRA is associated with improved long-term clinical outcomes in patients with AMI.
authors.affiliation: Cardiology Division, Cardiovascular Center, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.
authors.forename: Ik Jun
authors.initials: IJ
authors.lastname: Choi
authors.affiliation: Cardiology Division, Cardiovascular Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Yoon-Seok
authors.initials: YS
authors.lastname: Koh
authors.affiliation: Cardiology Division, Cardiovascular Center, Bucheon St. Mary's Hospital, The Catholic University of Korea, Bucheon, Korea.
authors.forename: Sungmin
authors.initials: S
authors.lastname: Lim
authors.affiliation: Cardiology Division, Cardiovascular Center, Uijeongbu St Mary's Hospital, The Catholic University of Korea, Uijeongbu, Korea.
authors.forename: Eun Ho
authors.initials: EH
authors.lastname: Choo
authors.affiliation: Cardiology Division, Cardiovascular Center, St. Paul's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jin Jin
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Cardiology Division, Cardiovascular Center, St. Paul's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Byung-Hee
authors.initials: BH
authors.lastname: Hwang
authors.affiliation: Cardiology Division, Cardiovascular Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Tae-Hoon
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Cardiology Division, Cardiovascular Center, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.
authors.forename: Suk Min
authors.initials: SM
authors.lastname: Seo
authors.affiliation: Cardiology Division, Cardiovascular Center, Daejeon St. Mary's Hospital, The Catholic University of Korea, Daejeon, Korea.
authors.forename: Chan Joon
authors.initials: CJ
authors.lastname: Kim
authors.affiliation: Cardiology Division, Cardiovascular Center, Daejeon St. Mary's Hospital, The Catholic University of Korea, Daejeon, Korea.
authors.forename: Mahn-Won
authors.initials: MW
authors.lastname: Park
authors.affiliation: Cardiology Division, Cardiovascular Center, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Shin
authors.affiliation: Cardiology Division, Cardiovascular Center, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Yun-Seok
authors.initials: YS
authors.lastname: Choi
authors.affiliation: Cardiology Division, Cardiovascular Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Hun-Jun
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Cardiology Division, Cardiovascular Center, Daejeon St. Mary's Hospital, The Catholic University of Korea, Daejeon, Korea.
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Her
authors.affiliation: Cardiology Division, Cardiovascular Center, St. Paul's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Dong-Bin
authors.initials: DB
authors.lastname: Kim
authors.affiliation: Cardiology Division, Cardiovascular Center, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Chul Soo
authors.initials: CS
authors.lastname: Park
authors.affiliation: Cardiology Division, Cardiovascular Center, Uijeongbu St Mary's Hospital, The Catholic University of Korea, Uijeongbu, Korea.
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: Cardiology Division, Cardiovascular Center, St. Vincent's hospital, The Catholic University of Korea, Suwon, Korea.
authors.forename: Keon Woong
authors.initials: KW
authors.lastname: Moon
authors.affiliation: Cardiology Division, Cardiovascular Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Kiyuk
authors.initials: K
authors.lastname: Chang
authors.affiliation: Cardiology Division, Cardiovascular Center, Bucheon St. Mary's Hospital, The Catholic University of Korea, Bucheon, Korea.
authors.forename: Hee Yeol
authors.initials: HY
authors.lastname: Kim
authors.affiliation: Cardiology Division, Cardiovascular Center, St. Vincent's hospital, The Catholic University of Korea, Suwon, Korea.
authors.forename: Ki-Dong
authors.initials: KD
authors.lastname: Yoo
authors.affiliation: Cardiology Division, Cardiovascular Center, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.
authors.forename: Doo Soo
authors.initials: DS
authors.lastname: Jeon
authors.affiliation: Cardiology Division, Cardiovascular Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Wook-Sung
authors.initials: WS
authors.lastname: Chung
authors.affiliation: Cardiovascular Center, Chonnam National University Hospital, Chonnam National University, Gwangju, Korea.
authors.forename: Youngkeun
authors.initials: Y
authors.lastname: Ahn
authors.affiliation: Cardiovascular Center, Chonnam National University Hospital, Chonnam National University, Gwangju, Korea.
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Jeong
authors.affiliation: Cardiology Division, Cardiovascular Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Ki-Bae
authors.initials: KB
authors.lastname: Seung
authors.affiliation: Cardiology Division, Cardiovascular Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. Electronic address: bjheart@catholic.ac.kr.
authors.forename: Pum-Joon
authors.initials: PJ
authors.lastname: Kim
mesh_terms: D000368:Aged; D002908:Chronic Disease; D054059:Coronary Occlusion / Q000150:complications / Q000401:mortality / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000401:mortality / Q000628:therapy*; D062645:Percutaneous Coronary Intervention; D016016:Proportional Hazards Models; D012042:Registries; D013997:Time Factors; D016896:Treatment Outcome