title: Models of Inflammation: Carrageenan Air Pouch.
abstract: The subcutaneous air pouch is an in vivo model that can be used to study the components of acute and chronic inflammation, the resolution of the inflammatory response, the oxidative stress response, and potential therapeutic targets for treating inflammation. Injection of irritants into an air pouch in rats or mice induces an inflammatory response that can be quantified by the volume of exudate produced, the infiltration of cells, and the release of inflammatory mediators. The model presented in this unit has been extensively used to identify potential anti-inflammatory drugs.
authors.affiliation: Pharmacy Department, Health Sciences School, University of Brasília, Brazil.
authors.forename: Djane B
authors.initials: DB
authors.lastname: Duarte
authors.affiliation: Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana.|Department of Anesthesiology, Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Vasko
authors.affiliation: Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Jill C
authors.initials: JC
authors.lastname: Fehrenbacher
mesh_terms: D000818:Animals; D002351:Carrageenan / Q000494:pharmacology*; D004195:Disease Models, Animal; D005122:Exudates and Transudates / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism*; D051379:Mice; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*
chemical_list: D018836:Inflammation Mediators; D002351:Carrageenan
keywords: PGE2; TNF alpha; air pouch; animal model; carrageenan; edema; inflammation; inflammatory mediator; oxidative stress