title: A new fatty acid ester from an edible mushroom Rhizopogon luteolus.
abstract: Phytochemical investigation of the Rhizopogon luteolus Fr. led to the isolation of one new fatty acid ester, 3-hydroxy-2,4-dimethylheptacosyl acetate (1) together with two known compounds tetracosanoic acid (2) and ergosterol (3). 1D and 2D NMR, and MS techniques were used for structural elucidation. Phenolic and fatty acid compositions were identified using HPLC-DAD and GC-MSD, respectively. Fumaric acid was the major phenolic acid, whereas linoleic, stearic and oleic acids were the most abundant fatty acids. Antioxidant and anticholinesterase activities of the extracts and compounds (1-3) were tested spectrophotometrically. Among the extracts, hexane extract showed the highest activity in all tests, particularly in β-carotene-linoleic acid assay (IC50: 16.65 ± 1.12 μg/mL). Furthermore, compound 3 exhibited higher antioxidant and anticholinesterase activities. The study indicates that R. luteolus can be used in food, cosmetic and pharmaceutical industries.
authors.affiliation: a Faculty of Sciences, Department of Chemistry , Muğla Sıtkı Koçman University , Muğla , Turkey.
authors.forename: Gülsen
authors.initials: G
authors.lastname: Tel-Çayan
authors.affiliation: a Faculty of Sciences, Department of Chemistry , Muğla Sıtkı Koçman University , Muğla , Turkey.|b H.E.J. Research Institute of Chemistry, ICCBS , University of Karachi , Karachi , Pakistan.
authors.forename: Akhtar
authors.initials: A
authors.lastname: Muhammad
authors.affiliation: a Faculty of Sciences, Department of Chemistry , Muğla Sıtkı Koçman University , Muğla , Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Duru
authors.affiliation: a Faculty of Sciences, Department of Chemistry , Muğla Sıtkı Koçman University , Muğla , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Öztürk
authors.affiliation: b H.E.J. Research Institute of Chemistry, ICCBS , University of Karachi , Karachi , Pakistan.
authors.forename: Achyut
authors.initials: A
authors.lastname: Adhikari
authors.affiliation: c Faculty of Sciences, Department of Biology , Muğla Sıtkı Koçman University , Muğla , Turkey.
authors.forename: Aziz
authors.initials: A
authors.lastname: Türkoğlu
mesh_terms: D000085:Acetates / Q000302:isolation & purification* / Q000494:pharmacology*; D000363:Agaricales / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005227:Fatty Acids / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D005233:Fatty Alcohols / Q000302:isolation & purification* / Q000494:pharmacology*; D006586:Hexanes / Q000737:chemistry; D019787:Linoleic Acid / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D019207:beta Carotene / Q000737:chemistry
chemical_list: C000619081:3-hydroxy-2,4-dimethylheptacosyl acetate; D000085:Acetates; D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D005227:Fatty Acids; D005233:Fatty Alcohols; D006586:Hexanes; D010936:Plant Extracts; D019207:beta Carotene; C026385:n-hexane; D019787:Linoleic Acid; C010210:lignoceric acid
keywords: Rhizopogon luteolus; anticholinesterase activity; antioxidant activity; ergosterol; fatty acid; phenolic compounds