title: Salvage transoral laser microsurgery for recurrent glottic carcinoma after primary laser-assisted treatment: Analysis of prognostic factors.
abstract: Treatment for local glottic cancer recurrences after primary transoral laser microsurgery (TLM) has not been standardized.
  
  
  
  In 33 consecutive cases of salvage TLM after laser surgery for early glottic carcinoma failed, we retrospectively considered the potential clinicopathological prognostic factors in univariate statistical setting.
  
  
  
  Patient age <65 years and pathological involvement of the deep margins were associated with a higher second recurrence rate and shorter disease-free survival.
  
  
  
  The age of the patient and the pathological status of surgical margins after salvage TLM could be useful for planning a closer endoscopic/radiological follow-up in selected patients at high risk of recurrence. Other appropriately designed studies are needed to see if an open surgical approach should be considered for younger patients (<65 years old) with recurrent glottic carcinoma after primary TLM. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1043-1049, 2016.
authors.affiliation: Otolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Lucioni
authors.affiliation: Otolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy.
authors.forename: Andy
authors.initials: A
authors.lastname: Bertolin
authors.affiliation: Otolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy.|Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Lionello
authors.affiliation: Department of Medicine DIMED, University of Padova, Padova, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Giacomelli
authors.affiliation: Otolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rizzotto
authors.affiliation: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
authors.forename: Gino
authors.initials: G
authors.lastname: Marioni
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005931:Glottis / Q000473:pathology / Q000601:surgery; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012086:Reoperation / Q000379:methods; D012189:Retrospective Studies; D018570:Risk Assessment; D016879:Salvage Therapy / Q000379:methods*; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: glottic carcinoma; laser; prognosis; recurrence; salvage