title: Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells.
abstract: Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells. To improve its potency and selectivity, an analog library of salinomycin was generated by site-specific modification and CuAAc derivatization. Through a cytotoxicity analysis of the library, a fluorinated analog with high potency, selectivity, and (19)F MRI sensitivity was discovered as a novel theranostic agent.
authors.affiliation: School of Pharmaceutical Sciences and College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430071, China. zxjiang@whu.edu.cn.
authors.forename: Qiuyan
authors.initials: Q
authors.lastname: Shi
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Shaowei
authors.initials: S
authors.lastname: Bo
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Yang
authors.forename: Hengjiang
authors.initials: H
authors.lastname: Cong
authors.forename: Hexiang
authors.initials: H
authors.lastname: Deng
authors.forename: Mingnan
authors.initials: M
authors.lastname: Chen
authors.forename: Shizhen
authors.initials: S
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.forename: Hong
authors.initials: H
authors.lastname: Ding
authors.forename: Zhong-Xing
authors.initials: ZX
authors.lastname: Jiang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D054879:Halogenation; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D008958:Models, Molecular; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011714:Pyrans / Q000737:chemistry* / Q000494:pharmacology*; D000095662:Polyether Polyketides
chemical_list: D000970:Antineoplastic Agents; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides