title: Synthesis of Rumphellaone A and Hushinone by a Gold-Catalyzed [2 + 2] Cycloaddition.
abstract: The enantioselective total synthesis of rumphellaone A has been accomplished in 12 steps via a diastereoselective gold(I)-catalyzed [2 + 2] macrocyclization of a 1,10-enyne as the key step to build the cyclobutene moiety. This concise approach has also led to the total synthesis of husinone.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology , Av Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Ranieri
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology , Av Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: Carla
authors.initials: C
authors.lastname: Obradors
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology , Av Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: Mauro
authors.initials: M
authors.lastname: Mato
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology , Av Països Catalans 16, 43007 Tarragona, Spain.|Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili , C/Marcel·li Domingo s/n, 43007 Tarragona, Spain.
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Echavarren
mesh_terms: D002384:Catalysis; D061565:Cycloaddition Reaction; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D054830:Sesterterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D012717:Sesquiterpenes; D054830:Sesterterpenes; C000610007:hushinone; C000610006:rumphellaone A; D006046:Gold