title: Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease.
abstract: Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on progranulin regulation in neurodegenerative diseases remains limited. We here demonstrate that cerebrospinal fluid progranulin levels do not correlate with its serum levels in AD, FTD and ALS, indicating a differential regulation of its central and peripheral levels in neurodegeneration. Blood progranulin levels thus do not reliably predict central nervous progranulin levels and their response to future progranulin-increasing therapeutics.
authors.forename: Carlo
authors.initials: C
authors.lastname: Wilke
authors.forename: Frank
authors.initials: F
authors.lastname: Gillardon
authors.forename: Christian
authors.initials: C
authors.lastname: Deuschle
authors.forename: Evelyn
authors.initials: E
authors.lastname: Dubois
authors.forename: Markus A
authors.initials: MA
authors.lastname: Hobert
authors.forename: Jennifer
authors.initials: J
authors.lastname: Müller vom Hagen
authors.forename: Stefanie
authors.initials: S
authors.lastname: Krüger
authors.forename: Saskia
authors.initials: S
authors.lastname: Biskup
authors.forename: Cornelis
authors.initials: C
authors.lastname: Blauwendraat
authors.forename: Michael
authors.initials: M
authors.lastname: Hruscha
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Kaeser
authors.forename: Peter
authors.initials: P
authors.lastname: Heutink
authors.forename: Walter
authors.initials: W
authors.lastname: Maetzler
authors.affiliation: Department of Neurodegenerative Diseases, University of Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany. matthis.synofzik@uni-tuebingen.de.
authors.forename: Matthis
authors.initials: M
authors.lastname: Synofzik
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D057180:Frontotemporal Dementia / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D000077153:Progranulins
chemical_list: D015415:Biomarkers; C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins