title: The 2016 revision of the World Health Organization classification of lymphoid neoplasms.
abstract: A revision of the nearly 8-year-old World Health Organization classification of the lymphoid neoplasms and the accompanying monograph is being published. It reflects a consensus among hematopathologists, geneticists, and clinicians regarding both updates to current entities as well as the addition of a limited number of new provisional entities. The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies. The major changes are reviewed with an emphasis on the most important advances in our understanding that impact our diagnostic approach, clinical expectations, and therapeutic strategies for the lymphoid neoplasms.
authors.affiliation: Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA;
authors.forename: Steven H
authors.identifier: 0000-0002-3832-3329
authors.initials: SH
authors.lastname: Swerdlow
authors.affiliation: Department of Pathology, Hospital Clinic, University of Barcelona, August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain;
authors.forename: Elias
authors.initials: E
authors.lastname: Campo
authors.affiliation: Haematopathology Unit, European Institute of Oncology, Milan, and Department of Experimental, Diagnostic and Specialty Medicine, Bologna University Medical School, Bologna, Italy;
authors.forename: Stefano A
authors.initials: SA
authors.lastname: Pileri
authors.affiliation: Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA;
authors.forename: Nancy Lee
authors.initials: NL
authors.lastname: Harris
authors.affiliation: Pathodiagnostik, Berlin, Germany;
authors.forename: Harald
authors.initials: H
authors.lastname: Stein
authors.affiliation: Institute of Human Genetics, Christian Albrechts University Kiel, Kiel, Germany;
authors.forename: Reiner
authors.initials: R
authors.lastname: Siebert
authors.affiliation: Division of Oncology, Department of Medicine, Stanford University, Stanford, CA;
authors.forename: Ranjana
authors.initials: R
authors.lastname: Advani
authors.affiliation: Department of Medical Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland;
authors.forename: Michele
authors.initials: M
authors.lastname: Ghielmini
authors.affiliation: Department of Hematology, Hospices Civils de Lyon, and Université Claude Bernard Lyon-1, Lyon, France;
authors.forename: Gilles A
authors.identifier: 0000-0002-9541-8666
authors.initials: GA
authors.lastname: Salles
authors.affiliation: Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY; and.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Zelenetz
authors.affiliation: Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD.
authors.forename: Elaine S
authors.identifier: 0000-0003-4632-0301
authors.initials: ES
authors.lastname: Jaffe
mesh_terms: D052138:Genes, Neoplasm; D006801:Humans; D007945:Leukemia, Lymphoid / Q000145:classification* / Q000235:genetics / Q000473:pathology; D008206:Lymphatic Diseases / Q000145:classification / Q000235:genetics / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008223:Lymphoma / Q000145:classification* / Q000235:genetics / Q000473:pathology; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D010265:Paraproteinemias / Q000145:classification / Q000235:genetics / Q000473:pathology; D014944:World Health Organization
chemical_list: D015514:Oncogene Proteins, Fusion