title: [Association of CTLA4 and TNF gene polymorphisms with endocrine ophthalmopathy in ethnic Russian patients with Graves' disease].
abstract: OBJECTIVE
  To analyze the associations of the rs3087243 CTLA4 polymorphism and the rs1800629 TNF polymorphism with endocrine ophthalmopathy (EOP) in ethnic Russian patients with Graves' disease (GD).
  
  
  METHODS
  The case-control study enrolled 205 patients with GD. The distribution of alleles and genotypes of the rs3087243 CTLA4 and rs1800629 TNF polymorphisms was studied in 141 patients with GD and EOP (a GD+EOP group) and 64 patients with GD without EOP (a GD-EOP group). The polymorphic alleles were identified by polymerase chain reaction-restriction fragment length analysis.
  
  
  RESULTS
  The patients with GD in their history and EOP had significantly higher frequencies of A allele and AA genotype and a lower proportion of G allele and GG genotype of the rs3087243 CTLA4 polymorphism. Comparative analysis revealed no significant differences in the frequency of the alleles and genotypes of the rs1800629 TNF polymorphism.
  
  
  CONCLUSIONS
  The rs3087243 CTLA4 polymorphism is associated with the risk of EOP in ethnic Russian patients with GD.
authors.affiliation: I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia; N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
authors.forename: N S
authors.initials: NS
authors.lastname: Martirosian
authors.affiliation: N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Burdennyi
authors.affiliation: I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Trukhina
authors.affiliation: Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of Russia, Moscow, Russia.
authors.forename: O G
authors.initials: OG
authors.lastname: Panteleeva
authors.affiliation: Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of Russia, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Saakyan
authors.affiliation: I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Petunina
authors.affiliation: N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Nosikov