title: Trabeculectomy in eyes with unsuspected retinoblastoma.
abstract: To report the management and clinical outcome of children with unsuspected retinoblastoma who underwent trabeculectomy surgery.
  
  
  
  Three children who presented to us after trabeculectomy surgery were diagnosed with retinoblastoma. They were treated with enucleation of the affected eye. Histopathology of the enucleated eyeball showed tumor infiltration into the iris and the ciliary body in two cases, and massive choroidal invasion in the third case. Six cycles of adjuvant systemic chemotherapy with carboplatin, vincristine and etoposide were given.
  
  
  
  The follow-up ranged from 18-48 months. At last follow-up, all children were alive and well, with no local recurrence or systemic metastasis.
  
  
  
  The management of retinoblastoma with operated trabeculectomy is challenging due to risk of tumor dissemination. Timely intervention can result in good clinical outcome. Nevertheless, a meticulous posterior segment evaluation to rule out retinoblastoma in children presenting with buphthalmos or secondary glaucoma should always be considered.
authors.affiliation: a Ocular Oncology & Pediatric Ophthalmology Service, Dr Rajendra Prasad Center for Ophthalmic Sciences , All India Institute of Medical Sciences , New Delhi , India.
authors.forename: Bhavna
authors.initials: B
authors.lastname: Chawla
authors.affiliation: a Ocular Oncology & Pediatric Ophthalmology Service, Dr Rajendra Prasad Center for Ophthalmic Sciences , All India Institute of Medical Sciences , New Delhi , India.
authors.forename: Maya
authors.initials: M
authors.lastname: Hada
authors.affiliation: b Pediatric Oncology Division, All India Institute of Medical Sciences , New Delhi , India.
authors.forename: Rachna
authors.initials: R
authors.lastname: Seth
authors.affiliation: c Ocular Pathology Service, Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute for Medical Sciences , New Delhi , India.
authors.forename: Seema
authors.initials: S
authors.lastname: Sen
authors.affiliation: a Ocular Oncology & Pediatric Ophthalmology Service, Dr Rajendra Prasad Center for Ophthalmic Sciences , All India Institute of Medical Sciences , New Delhi , India.
authors.forename: Viney
authors.initials: V
authors.lastname: Gupta
authors.affiliation: c Ocular Pathology Service, Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute for Medical Sciences , New Delhi , India.
authors.forename: Seema
authors.initials: S
authors.lastname: Kashyap
authors.affiliation: a Ocular Oncology & Pediatric Ophthalmology Service, Dr Rajendra Prasad Center for Ophthalmic Sciences , All India Institute of Medical Sciences , New Delhi , India.
authors.forename: Pinto C
authors.initials: PC
authors.lastname: Narasimhaiah
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D002675:Child, Preschool; D005047:Etoposide / Q000627:therapeutic use; D015353:Eye Enucleation; D005260:Female; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009361:Neoplasm Invasiveness; D019572:Retinal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D012175:Retinoblastoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014129:Trabecular Meshwork / Q000601:surgery*; D014130:Trabeculectomy; D014604:Uveal Neoplasms / Q000473:pathology* / Q000628:therapy; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D005047:Etoposide; D016190:Carboplatin
keywords: Retinoblastoma; trabeculectomy; unsuspected