title: Recent advances in production, purification and applications of phycobiliproteins.
abstract: An obligatory sunlight requirement for photosynthesis has exposed cyanobacteria to different quantity and quality of light. Cyanobacteria can exhibit efficient photosynthesis over broad region (450 to 650 nm) of solar spectrum with the help of brilliantly coloured pigment proteins called phycobiliproteins (PBPs). Besides light-harvesting, PBPs are found to involve in several life sustaining phenomena including photoprotection in cyanobacteria. The unique spectral features (like strong absorbance and fluorescence), proteineous nature and, some imperative properties like hepato-protective, anti-oxidants, anti-inflammatory and anti-aging activity of PBPs enable their use in food, cosmetics, pharmaceutical and biomedical industries. PBPs have been also noted to show beneficial effect in therapeutics of some disease like Alzheimer and cancer. Such large range of applications increases the demand of PBPs in commodity market. Therefore, the large-scale and coast effective production of PBPs is the real need of time. To fulfil this need, many researchers have been working to find the potential producer of PBPs for the production and purification of PBPs. Results of these efforts have caused the inventions of some novel techniques like mixotrophic and heterotrophic strategies for production and aqueous two phase separation for purification purpose. Overall, the present review summarises the recent findings and identifies gaps in the field of production, purification and applications of this biological and economically important proteins.
authors.affiliation: Ravi Raghav Sonani, Rajesh Prasad Rastogi, Rutvij Patel, Datta Madamwar, BRD School of Biosciences, Sardar Patel University, Vallabh Vidyanagar 388120, Anand, Gujarat, India.
authors.forename: Ravi Raghav
authors.initials: RR
authors.lastname: Sonani
authors.affiliation: Ravi Raghav Sonani, Rajesh Prasad Rastogi, Rutvij Patel, Datta Madamwar, BRD School of Biosciences, Sardar Patel University, Vallabh Vidyanagar 388120, Anand, Gujarat, India.
authors.forename: Rajesh Prasad
authors.initials: RP
authors.lastname: Rastogi
authors.affiliation: Ravi Raghav Sonani, Rajesh Prasad Rastogi, Rutvij Patel, Datta Madamwar, BRD School of Biosciences, Sardar Patel University, Vallabh Vidyanagar 388120, Anand, Gujarat, India.
authors.forename: Rutvij
authors.initials: R
authors.lastname: Patel
authors.affiliation: Ravi Raghav Sonani, Rajesh Prasad Rastogi, Rutvij Patel, Datta Madamwar, BRD School of Biosciences, Sardar Patel University, Vallabh Vidyanagar 388120, Anand, Gujarat, India.
authors.forename: Datta
authors.initials: D
authors.lastname: Madamwar
keywords: Cyanobacteria; Fluorescence; Nutraceutical; Pharmaceutical; Phycobiliproteins