title: Use of Concomitant Antibiotics During Treatment for Clostridium difficile Infection (CDI) in Pediatric Inpatients: An Observational Cohort Study.
abstract: Concomitant antibiotic use during treatment for Clostridium difficile infection (CDI) increases the risk of recurrence. Across a network of children's hospitals, 46% of patients treated for CDI received concomitant antibiotics for a median of 7 days. Concomitant antibiotic use was more common among patients with malignancies, and solid organ or bone marrow transplant. Unnecessary concomitant antibiotic use in CDI patients is a potential target for pediatric antimicrobial stewardship.
authors.affiliation: Department of Pharmacotherapy, University of Utah College of Pharmacy, 30 South 2000 East, Rm 4961, Salt Lake City, UT, 84121, USA. vanessa.stevens@pharm.utah.edu.
authors.forename: Vanessa W
authors.initials: VW
authors.lastname: Stevens
authors.affiliation: Children's Hospital Association, Washington D.C., MD, USA.
authors.forename: Cary
authors.initials: C
authors.lastname: Thurm
authors.affiliation: Department of Pharmacotherapy, University of Utah College of Pharmacy, 30 South 2000 East, Rm 4961, Salt Lake City, UT, 84121, USA.
authors.forename: Elyse M
authors.initials: EM
authors.lastname: Schwab
authors.affiliation: Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Kronman
authors.affiliation: Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Gerber
authors.affiliation: Division of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Samir S
authors.initials: SS
authors.lastname: Shah
authors.affiliation: Division of Infectious Diseases, Children's Mercy Hospitals and Clinics, University of Missouri, Kansas City, MO, USA.
authors.forename: Jason G
authors.initials: JG
authors.lastname: Newland
authors.affiliation: Division of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: Courter
authors.affiliation: Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Parker
authors.affiliation: Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.
authors.forename: Thomas V
authors.initials: TV
authors.lastname: Brogan
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
authors.forename: Adam L
authors.initials: AL
authors.lastname: Hersh
keywords: Clostridium difficile infection; Concomitant antibiotics; Pediatric