title: Timed Rise from Floor as a Predictor of Disease Progression in Duchenne Muscular Dystrophy: An Observational Study.
abstract: BACKGROUND
  The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys.
  
  
  METHODS
  A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS).
  
  
  RESULTS
  The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p<0.01).
  
  
  CONCLUSIONS
  Both time to rise from the floor and baseline 6MWT were relevant for predicting 6MWT changes in the group above the age of 7 years, with no interaction between the two measures, as the impact of time to rise from the floor on 6MWT change was similar in the patients below and above 350 m. Our results suggest that, time to rise from the floor can be considered an additional important prognostic factor of 12 month changes on the 6MWT and, more generally, of disease progression.
authors.affiliation: Department of Paediatric Neurology, Catholic University, Rome, Italy.
authors.forename: Elena S
authors.initials: ES
authors.lastname: Mazzone
authors.affiliation: Department of Paediatric Neurology, Catholic University, Rome, Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Coratti
authors.affiliation: Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy.
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Sormani
authors.affiliation: Department of Neurosciences and Nemo and Clinical Center, Psychiatry and Anaesthesiology, University of Messina, Messina, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Messina
authors.affiliation: Department of Paediatric Neurology, Catholic University, Rome, Italy.
authors.forename: Marika
authors.initials: M
authors.lastname: Pane
authors.affiliation: Unit of Neuromuscular and Neurodegenerative Diseases, Department of Neurosciences, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Adele
authors.initials: A
authors.lastname: D'Amico
authors.affiliation: Unit of Neuromuscular and Neurodegenerative Diseases, Department of Neurosciences, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Colia
authors.affiliation: Department of Paediatric Neurology, Catholic University, Rome, Italy.
authors.forename: Lavinia
authors.initials: L
authors.lastname: Fanelli
authors.affiliation: Child Neurology and Psychiatry Unit, "C. Mondino" Foundation, Pavia, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Berardinelli
authors.affiliation: Child Neurology and Psychiatry Unit, "C. Mondino" Foundation, Pavia, Italy.
authors.forename: Alice
authors.initials: A
authors.lastname: Gardani
authors.affiliation: Neuromuscular Disease Unit, G. Gaslini Institute, Genoa, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Lanzillotta
authors.affiliation: Cardiomiologia e genetica medica, Dipartimento di Medicina Sperimentale, Seconda Università di Napoli, Napoli, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: D'Ambrosio
authors.affiliation: Cardiomiologia e genetica medica, Dipartimento di Medicina Sperimentale, Seconda Università di Napoli, Napoli, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Petillo
authors.affiliation: Department of Neurosciences and Nemo and Clinical Center, Psychiatry and Anaesthesiology, University of Messina, Messina, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Cavallaro
authors.affiliation: Department of Developmental Neuroscience, Stella Maris Institute, Pisa,Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Frosini
authors.affiliation: Department of Neurosciences, University of Padua, Padua, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Bello
authors.affiliation: Child Neurology and Psychiatry Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Bonfiglio
authors.affiliation: Department of Paediatric Neurology, Catholic University, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: De Sanctis
authors.affiliation: Neuromuscular Center, SG. Battista Hospital, University of Turin, Turin, Italy.
authors.forename: Enrica
authors.initials: E
authors.lastname: Rolle
authors.affiliation: Department of Paediatric Neurology, Catholic University, Rome, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Forcina
authors.affiliation: Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Neurology Unit, IRCSS Foudation, Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Magri
authors.affiliation: Department of Neurosciences and Nemo and Clinical Center, Psychiatry and Anaesthesiology, University of Messina, Messina, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Vita
authors.affiliation: Department of Paediatric Neurology, Catholic University, Rome, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Palermo
authors.affiliation: Metabolic and Neuromuscular Unit, Meyer Hospital, Florence, Italy.
authors.forename: Maria Alice
authors.initials: MA
authors.lastname: Donati
authors.affiliation: Metabolic and Neuromuscular Unit, Meyer Hospital, Florence, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Procopio
authors.affiliation: Developmental Neurology Unit, Istituto Neurologico "Besta" Milan, Milan, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Arnoldi
authors.affiliation: Developmental Neurology Unit, Istituto Neurologico "Besta" Milan, Milan, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Baranello
authors.affiliation: Neuromuscular Center, SG. Battista Hospital, University of Turin, Turin, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Mongini
authors.affiliation: Child Neurology and Psychiatry Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Pini
authors.affiliation: Department of Developmental Neuroscience, Stella Maris Institute, Pisa,Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Battini
authors.affiliation: Department of Neurosciences, University of Padua, Padua, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Pegoraro
authors.affiliation: Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Neurology Unit, IRCSS Foudation, Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Torrente
authors.affiliation: Neuromuscular repair unit, Inspe and division of neuroscience, IRCSS San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Stefano C
authors.initials: SC
authors.lastname: Previtali
authors.affiliation: Neuromuscular Disease Unit, G. Gaslini Institute, Genoa, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Bruno
authors.affiliation: Cardiomiologia e genetica medica, Dipartimento di Medicina Sperimentale, Seconda Università di Napoli, Napoli, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Politano
authors.affiliation: Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Neurology Unit, IRCSS Foudation, Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Giacomo P
authors.initials: GP
authors.lastname: Comi
authors.affiliation: Neuromuscular Disorders Unit, Scientific Institute IRCCS E. Medea, 23842, Bosisio Parini, Lecco, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: D'Angelo
authors.affiliation: Unit of Neuromuscular and Neurodegenerative Diseases, Department of Neurosciences, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Bertini
authors.affiliation: Department of Paediatric Neurology, Catholic University, Rome, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Mercuri
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D006801:Humans; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000473:pathology*; D055815:Young Adult