title: The diet-microbiota-metabolite axis regulates the host physiology.
abstract: The intestinal microbiota has been implicated in a wide range of diseases, including inflammatory bowel disease, obesity and cancer. Food ingredients are considered a major determinant of gut microbial composition, as exemplified by high-fat diet-induced dysbiosis that can affect host physiology. Accumulating studies show that microbial metabolites are key regulators of the intestinal epithelial barrier and gut immunity. In particular, short-chain fatty acids produced by bacterial fermentation of indigestible polysaccharides have profound impacts on host physiology beyond the gut. In this review, we describe the influences of the diet-microbiota-metabolite axis on host physiology, and especially on the immune and metabolic systems.
authors.affiliation: Division of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo 105-8512, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamada
authors.affiliation: Division of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo 105-8512, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takahashi
authors.affiliation: Division of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo 105-8512, Japan Division of Mucosal Barriology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science the University of Tokyo, Tokyo 108-8639, Japan hase-kj@pha.keio.ac.jp.
authors.forename: Koji
authors.initials: K
authors.lastname: Hase
mesh_terms: D000818:Animals; D004032:Diet; D005227:Fatty Acids / Q000378:metabolism*; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology*
chemical_list: D005227:Fatty Acids
keywords: commensal microbiota; diet; epithelial barrier; immune system; short chain fatty acid