title: Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds.
abstract: The aim of this review is to provide an update on the current use of cyclodextrins against organophosphorus compound intoxications. Organophosphorus pesticides and nerve agents play a determinant role in the inhibition of cholinesterases. The cyclic structure of cyclodextrins and their toroidal shape are perfectly suitable to design new chemical scavengers able to trap and hydrolyze the organophosphorus compounds before they reach their biological target.
authors.affiliation: Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA de Rouen, CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Letort
authors.affiliation: Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA de Rouen, CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Balieu
authors.affiliation: Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA de Rouen, CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France.
authors.forename: William
authors.initials: W
authors.lastname: Erb
authors.affiliation: Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA de Rouen, CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Gouhier
authors.affiliation: Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA de Rouen, CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France.
authors.forename: François
authors.initials: F
authors.lastname: Estour
keywords: cyclodextrin; enzyme mimic; nerve agents; organophosphorus compounds; pesticides