title: [Differential expression β₂ and β₄ isoforms of retinoic acid receptor gene RARβ as possible prognostic factor in multiple myeloma].
abstract: In this study, for the first time the expression of β₂ and β₄ isoforms of RARβ gene was investigated in group of 19 patients with the newly diagnosed multiple myeloma. The expression of both RARβ₂ and RARβ₄ isoforms was detected in all patients, but it was different and had opposite tendency. We showed that RARβ₄ expression level positively correlated with VEGF-A and VEGFR1 expression levels. It was found that higher levels of RARβ₄/VEGF-A/VEGFR1 co-expression were defined of patients with statistically significant increase of plasma cell level and paraprotein concentration. The median overall survival was lower in patients with RARβ₄, over-expression, while the maximal median overall survival was observed of patients with RARβ₂ down-regulation and nearly absolute RARβ₄inactivation.
authors.forename: N N
authors.initials: NN
authors.lastname: Kalitin
authors.forename: I V
authors.initials: IV
authors.lastname: Buravtsova
mesh_terms: D000328:Adult; D000368:Aged; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000378:metabolism* / Q000401:mortality; D020033:Protein Isoforms; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000378:metabolism*; D016019:Survival Analysis; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D020033:Protein Isoforms; D018168:Receptors, Retinoic Acid; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C082925:retinoic acid receptor beta; D040281:Vascular Endothelial Growth Factor Receptor-1