title: Expression of PIN1 in Gastrointestinal Stromal Tumours and its Clinical Significance.
abstract: BACKGROUND
  The malignancy of gastrointestinal stromal tumours (GIST) varies greatly. Due to the uncertainty of specific molecular pathogenesis and complexity of biological behaviour of GIST, the aggressiveness and prognosis of GIST cannot be precisely predicted.
  
  
  METHODS
  We retrieved 40 paraffin-embedded specimens of surgically resected GIST between January 2013 and May 2015 at the Pathology Department of Yuhuangding Hospital Affiliated to Qingdao University and detected the expression of NIMA-interacting peptidylprolyl isomerase (PIN1) and Ki67, by immunohistochemical methods.
  
  
  RESULTS
  The positivity rate of PIN1 and Ki67 in GIST was 80% and 32.5%, respectively. The expression of PIN1 was associated with risk of malignancy, tumour location, tumour size, and mitotic counts. The expression of Ki67 was also associated with risk of malignancy, tumour location, tumour size, and mitotic counts. The expression of Ki67 was positively related to the expression of PIN1.
  
  
  CONCLUSIONS
  PIN1 and Ki67 may be potential factors predicting the malignancy of GIST. PIN1 may be an attractive prognostic indicator and therapeutic target for GIST.
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University-Yantai Yuhuangding Hospital, Yantai, Shandong Province, P.R. China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University-Yantai Yuhuangding Hospital, Yantai, Shandong Province, P.R. China.
authors.forename: Mingxiao
authors.initials: M
authors.lastname: Cao
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University-Yantai Yuhuangding Hospital, Yantai, Shandong Province, P.R. China.
authors.forename: Jinchen
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Oncology, Affiliated Hospital of Qingdao University-Yantai Yuhuangding Hospital, Yantai, Shandong Province, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D049109:Cell Proliferation; D002681:China; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D046152:Gastrointestinal Stromal Tumors / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase / Q000032:analysis*; D011379:Prognosis; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase
keywords: Gastrointestinal stromal tumours; Ki67 antigen; NIMA-interacting peptidylprolyl isomerase; immunohistochemistry