title: Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy.
abstract: Antibacterial resistance to infectious diseases is a significant global concern for health care organizations; along with aging populations and increasing cancer rates, it represents a great burden for government healthcare systems. Therefore, the development of therapies against bacterial infection and cancer is an important strategy for healthcare research. Pathogenic bacteria and cancer have developed a broad range of sophisticated strategies to survive or propagate inside a host and cause infection or spread disease. Bacteria can employ their own metabolism pathways to obtain nutrients from the host cells in order to survive. Similarly, cancer cells can dysregulate normal human cell metabolic pathways so that they can grow and spread. One common feature of the adaption and disruption of metabolic pathways observed in bacterial and cancer cell growth is amino acid pathways; these have recently been targeted as a novel approach to manage bacterial infections and cancer therapy. In particular, arginine metabolism has been illustrated to be important not only for bacterial pathogenesis but also for cancer therapy. Therefore, greater insights into arginine metabolism of pathogenic bacteria and cancer cells would provide possible targets for controlling of bacterial infection and cancer treatment. This review will summarize the recent progress on the relationship of arginine metabolism with bacterial pathogenesis and cancer therapy, with a particular focus on arginase and arginine deiminase pathways of arginine catabolism.
authors.affiliation: Department of Microbiology, The University of Hong Kong, Hong Kong, China. lfxiong@hku.hk.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Xiong
authors.affiliation: Department of Microbiology, The University of Hong Kong, Hong Kong, China. llteng@hku.hk.|Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China. llteng@hku.hk.|State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China. llteng@hku.hk.
authors.forename: Jade L L
authors.initials: JL
authors.lastname: Teng
authors.affiliation: Faculty of Dentistry, The University of Hong Kong, Hong Kong, China. botelho@hku.hk.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Botelho
authors.affiliation: Department of Pathology, The University of Hong Kong, Hong Kong, China. reginalo@pathology.hku.hk.|State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China. reginalo@pathology.hku.hk.
authors.forename: Regina C
authors.initials: RC
authors.lastname: Lo
authors.affiliation: Department of Microbiology, The University of Hong Kong, Hong Kong, China. skplau@hku.hk.|Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China. skplau@hku.hk.|State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China. skplau@hku.hk.|Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China. skplau@hku.hk.
authors.forename: Susanna K P
authors.initials: SK
authors.lastname: Lau
authors.affiliation: Department of Microbiology, The University of Hong Kong, Hong Kong, China. pcywoo@hku.hk.|Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China. pcywoo@hku.hk.|State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China. pcywoo@hku.hk.|Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China. pcywoo@hku.hk.
authors.forename: Patrick C Y
authors.initials: PC
authors.lastname: Woo
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001119:Arginase / Q000378:metabolism; D001120:Arginine / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001120:Arginine; D006867:Hydrolases; D001119:Arginase; C019723:arginine deiminase
keywords: arginase; arginine deiminase; arginine metabolism; bacterial pathogenesis; cancer therapy