title: Human CD56bright NK Cells: An Update.
abstract: Human NK cells can be subdivided into various subsets based on the relative expression of CD16 and CD56. In particular, CD56(bright)CD16(-/dim) NK cells are the focus of interest. They are considered efficient cytokine producers endowed with immunoregulatory properties, but they can also become cytotoxic upon appropriate activation. These cells were shown to play a role in different disease states, such as cancer, autoimmunity, neuroinflammation, and infection. Although their phenotype and functional properties are well known and have been extensively studied, their lineage relationship with other NK cell subsets is not fully defined, nor is their precise hematopoietic origin. In this article, we summarize recent studies about CD56(bright) NK cells in health and disease and briefly discuss the current controversies surrounding them.
authors.affiliation: Department of Infection and Immunity, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg;
authors.forename: Tatiana
authors.initials: T
authors.lastname: Michel
authors.affiliation: Department of Infection and Immunity, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg;
authors.forename: Aurélie
authors.initials: A
authors.lastname: Poli
authors.affiliation: Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, A-1090 Vienna, Austria; and.
authors.forename: Angelica
authors.initials: A
authors.lastname: Cuapio
authors.affiliation: Department of Infection and Immunity, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg;
authors.forename: Benjamin
authors.initials: B
authors.lastname: Briquemont
authors.affiliation: Department of Infection and Immunity, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg;
authors.forename: Gilles
authors.initials: G
authors.lastname: Iserentant
authors.affiliation: Department of Infection and Immunity, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg; Allergy Center, Department of Dermatology Odense Research Centre for Anaphylaxis, University of Southern Denmark, DK-5000 Odense, Denmark.
authors.forename: Markus
authors.initials: M
authors.lastname: Ollert
authors.affiliation: Department of Infection and Immunity, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg; jacques.zimmer@lih.lu.
authors.forename: Jacques
authors.initials: J
authors.lastname: Zimmer
mesh_terms: D000818:Animals; D019002:CD56 Antigen / Q000378:metabolism*; D002454:Cell Differentiation; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D010641:Phenotype
chemical_list: D019002:CD56 Antigen