title: Changes over lactation in breast milk serum proteins involved in the maturation of immune and digestive system of the infant.
abstract: Here we provide data from shot-gun proteomics, using filtered-aided sample preparation (FASP), dimethyl labeling and LC-MS/MS, to quantify the changes in the repertoire of human milk proteins over lactation. Milk serum proteins were analyzed at week 1, 2, 3 4, 8, 16, and 24 in milk from four individual mothers. A total of 247 proteins were identified, of which 200 proteins were quantified. The data supplied in this article supports the accompanying publication (Zhang et al., 2006) [1]. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium (Vizcaíno et al., 2016) [2] via the PRIDE partner repository with the dataset identifier PXD003465.
authors.affiliation: Dairy Science and Technology, Food Quality and Design group, Wageningen University, The Netherlands.
authors.forename: Lina
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Paediatrics, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Marita
authors.initials: M
authors.lastname: de Waard
authors.affiliation: Department of Paediatrics, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Hester
authors.initials: H
authors.lastname: Verheijen
authors.affiliation: Laboratory of Biochemistry, Wageningen University, The Netherlands.
authors.forename: Sjef
authors.initials: S
authors.lastname: Boeren
authors.affiliation: Biometris-Applied Statistics, Wageningen University, The Netherlands; Centre for BioSystems Genomics, Wageningen University, The Netherlands.
authors.forename: Jos A
authors.initials: JA
authors.lastname: Hageman
authors.affiliation: Dairy Science and Technology, Food Quality and Design group, Wageningen University, The Netherlands.
authors.forename: Toon
authors.initials: T
authors.lastname: van Hooijdonk
authors.affiliation: Laboratory of Biochemistry, Wageningen University, The Netherlands.
authors.forename: Jacques
authors.initials: J
authors.lastname: Vervoort
authors.affiliation: Department of Paediatrics, VU University Medical Center, Amsterdam, The Netherlands; Academic Medical Center, Emma Children׳s Hospital, Amsterdam, The Netherlands.
authors.forename: Johannes B
authors.initials: JB
authors.lastname: van Goudoever
authors.affiliation: Dairy Science and Technology, Food Quality and Design group, Wageningen University, The Netherlands.
authors.forename: Kasper
authors.initials: K
authors.lastname: Hettinga
keywords: Gastrointestinal tract; Immune system; Milk serum proteome; Protease inhibitors