title: Targeting obesity-related adipose tissue dysfunction to prevent cancer development and progression.
abstract: The incidence of obesity, a leading modifiable risk factor for common solid tumors, is increasing. Effective interventions are needed to minimize the public health implications of obesity. Although the mechanisms linking increased adiposity to malignancy are incompletely understood, growing evidence points to complex interactions among multiple systemic and tissue-specific pathways including inflamed white adipose tissue. The metabolic and inflammatory consequences of white adipose tissue dysfunction collectively provide a plausible explanation for the link between overweight/obesity and carcinogenesis. Gaining a better understanding of these underlying molecular pathways and developing risk assessment tools that identify at-risk populations will be critical in implementing effective and novel cancer prevention and management strategies.
authors.affiliation: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. Electronic address: gucalpa@mskcc.org.
authors.forename: Ayca
authors.initials: A
authors.lastname: Gucalp
authors.affiliation: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Neil M
authors.initials: NM
authors.lastname: Iyengar
authors.affiliation: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Clifford A
authors.initials: CA
authors.lastname: Hudis
authors.affiliation: Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Dannenberg
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D052436:Adipose Tissue, White / Q000378:metabolism / Q000503:physiopathology*; D000728:Androgens / Q000096:biosynthesis; D004967:Estrogens / Q000096:biosynthesis; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007333:Insulin Resistance; D020738:Leptin / Q000378:metabolism; D050356:Lipid Metabolism; D009369:Neoplasms / Q000517:prevention & control*; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy
chemical_list: D052242:Adiponectin; D000728:Androgens; D004967:Estrogens; D020738:Leptin
keywords: Adipose tissue; Body mass index; Cancer prevention; Inflammation; Metabolic syndrome; Obesity