title: The endoplasmic reticulum stress response: A link with tuberculosis?
abstract: Tuberculosis (TB) remains a major cause of mortality and morbidity in the worldwide. The endoplasmic-reticulum stress (ERS) response constitutes a cellular process that is triggered by mycobacterial infection that disturbs the folding of proteins in the endoplasmic reticulum (ER). The unfolded protein response (UPR) is induced to suspend the synthesis of early proteins and reduce the accumulation of unfolded- or misfolded proteins in the ER restoring normal physiological cell function. Prolonged or uncontrolled ERS leads to the activation of three signaling pathways (IRE1, PERK and ATF6) which directs the cell towards apoptosis. The absence of this process facilitates spread of the mycobacteria within the body. We summarize here recent advances in understanding the signaling pathway diversity governing ERS in relation to TB.
authors.affiliation: The State Key Lab of Agrobiotechnology, Key Lab of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National TSE Lab, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China. Electronic address: choiron@163.com.
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Cui
authors.affiliation: The State Key Lab of Agrobiotechnology, Key Lab of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National TSE Lab, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China. Electronic address: zhaodm@cau.edu.cn.
authors.forename: Deming
authors.initials: D
authors.lastname: Zhao
authors.affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Loughborough, Leicestershire, UK. Electronic address: paul.barrow@nottingham.ac.uk.
authors.forename: Paul Andrew
authors.initials: PA
authors.lastname: Barrow
authors.affiliation: The State Key Lab of Agrobiotechnology, Key Lab of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National TSE Lab, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China. Electronic address: zhouxm@cau.edu.cn.
authors.forename: Xiangmei
authors.initials: X
authors.lastname: Zhou
mesh_terms: D051702:Activating Transcription Factor 6 / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D020013:Calcium Signaling; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D059865:Endoplasmic Reticulum Stress; D004722:Endoribonucleases / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D014376:Tuberculosis / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D056811:Unfolded Protein Response; D019892:eIF-2 Kinase / Q000378:metabolism
chemical_list: C497111:ATF6 protein, human; D051702:Activating Transcription Factor 6; C460640:EIF2AK3 protein, human; C528229:ERN1 protein, human; D017346:Protein Serine-Threonine Kinases; D019892:eIF-2 Kinase; D004722:Endoribonucleases
keywords: Apoptosis; Endoplasmic-reticulum stress (ERS); Mycobacteria; The unfolded protein response (UPR); Tuberculosis