title: Distributed Cerebellar Motor Learning: A Spike-Timing-Dependent Plasticity Model.
abstract: Deep cerebellar nuclei neurons receive both inhibitory (GABAergic) synaptic currents from Purkinje cells (within the cerebellar cortex) and excitatory (glutamatergic) synaptic currents from mossy fibers. Those two deep cerebellar nucleus inputs are thought to be also adaptive, embedding interesting properties in the framework of accurate movements. We show that distributed spike-timing-dependent plasticity mechanisms (STDP) located at different cerebellar sites (parallel fibers to Purkinje cells, mossy fibers to deep cerebellar nucleus cells, and Purkinje cells to deep cerebellar nucleus cells) in close-loop simulations provide an explanation for the complex learning properties of the cerebellum in motor learning. Concretely, we propose a new mechanistic cerebellar spiking model. In this new model, deep cerebellar nuclei embed a dual functionality: deep cerebellar nuclei acting as a gain adaptation mechanism and as a facilitator for the slow memory consolidation at mossy fibers to deep cerebellar nucleus synapses. Equipping the cerebellum with excitatory (e-STDP) and inhibitory (i-STDP) mechanisms at deep cerebellar nuclei afferents allows the accommodation of synaptic memories that were formed at parallel fibers to Purkinje cells synapses and then transferred to mossy fibers to deep cerebellar nucleus synapses. These adaptive mechanisms also contribute to modulate the deep-cerebellar-nucleus-output firing rate (output gain modulation toward optimizing its working range).
authors.affiliation: Department of Computer Architecture and Technology, Research Centre for Information and Communications Technologies of the University of Granada (CITIC-UGR) Granada, Spain.
authors.forename: Niceto R
authors.initials: NR
authors.lastname: Luque
authors.affiliation: Department of Computer Architecture and Technology, Research Centre for Information and Communications Technologies of the University of Granada (CITIC-UGR) Granada, Spain.
authors.forename: Jesús A
authors.initials: JA
authors.lastname: Garrido
authors.affiliation: Department of Computer Architecture and Technology, Research Centre for Information and Communications Technologies of the University of Granada (CITIC-UGR) Granada, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Naveros
authors.affiliation: Department of Computer Architecture and Technology, Research Centre for Information and Communications Technologies of the University of Granada (CITIC-UGR) Granada, Spain.
authors.forename: Richard R
authors.initials: RR
authors.lastname: Carrillo
authors.affiliation: Brain Connectivity Center, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Neurologico Nazionale Casimiro MondinoPavia, Italy; Department of Brain and Behavioural Sciences, University of PaviaPavia, Italy.
authors.forename: Egidio
authors.initials: E
authors.lastname: D'Angelo
authors.affiliation: Department of Computer Architecture and Technology, Research Centre for Information and Communications Technologies of the University of Granada (CITIC-UGR) Granada, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ros
keywords: cerebellar modeling; cerebellar motor control; cerebellar nuclei; motor learning consolidation; spike-timing-dependent plasticity