title: [Effect of caffeine citrate on early pulmonary function in preterm infants with apnea].
abstract: OBJECTIVE
  To investigate the effect of caffeine citrate treatment on early pulmonary function in preterm infants with apnea.
  
  
  METHODS
  Forty preterm infants with apnea were randomly divided into aminophylline treatment group (20 infants) and caffeine citrate treatment group (20 infants). When the preterm infants experienced apnea after birth, they were given aminophylline or caffeine citrate in addition to assisted ventilation with continuous positive airway pressure (NCPAP). After drug discontinuation, pulmonary function was measured and compared between the two groups.
  
  
  RESULTS
  After treatment, compared with the aminophylline treatment group, the caffeine citrate treatment group had significantly higher tidal volume, minute ventilation volume, ratio of time to peak tidal expiratory flow to total expiratory time, ratio of volume to peak tidal expiratory flow to total expiratory volume, peak expiratory flow, and breathing flow at 75%, 50%, and 25% of tidal volume (P<0.05). The caffeine citrate treatment group had a significantly shorter time of oxygen use and NCPAP support than the aminophylline treatment group (P<0.01). Compared with the aminophylline treatment group, the caffeine citrate treatment group had a significantly lower frequency of apnea attacks (P<0.01).
  
  
  CONCLUSIONS
  In the treatment of apnea in preterm infants, caffeine citrate can improve early pulmonary function and reduce the incidence of apnea.
authors.affiliation: Department of Pediatrics, Binhu Hospital of Southern District, First Hospital of Hefei City, Hefei 230061, China. wenxiaohong2007@163.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Yu
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Huang
authors.forename: Rong
authors.initials: R
authors.lastname: Zhu
authors.forename: Xu-Zhong
authors.initials: XZ
authors.lastname: Zhang
authors.forename: Wan-Yun
authors.initials: WY
authors.lastname: Wu
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Wen
mesh_terms: D000628:Aminophylline / Q000627:therapeutic use; D001049:Apnea / Q000188:drug therapy* / Q000503:physiopathology; D002110:Caffeine / Q000494:pharmacology / Q000627:therapeutic use*; D002951:Citrates / Q000494:pharmacology / Q000627:therapeutic use*; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008297:Male
chemical_list: D002951:Citrates; D000628:Aminophylline; D002110:Caffeine; C026189:caffeine citrate