title: Protein Formulations for Emulsions and Solid-in-Oil Dispersions.
abstract: Needs from medical and cosmetic areas have led to the design of novel nanosized emulsions and solid-in-oil dispersions of proteins. Here, we describe the production of those emulsions and dispersions using high-energy methodologies such as high-pressure homogenization or ultrasound. Recent work has resulted in new mechanistic insights related to the formation of protein emulsions and dispersions. The production method and composition of these formulations can determine major parameters such as size, stability, and functionality, and therefore their final application. Aqueous nanoemulsions of proteins can be used for drug delivery, while solid-in-oil dispersions are often used in transdermal applications.
authors.affiliation: Centre of Biological Engineering (CEB), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.
authors.forename: Madalena
authors.initials: M
authors.lastname: Martins
authors.affiliation: Centre of Biological Engineering (CEB), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Loureiro
authors.affiliation: Centre of Biological Engineering (CEB), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.
authors.forename: Nuno G
authors.initials: NG
authors.lastname: Azoia
authors.affiliation: Centre of Biological Engineering (CEB), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.
authors.forename: Carla
authors.initials: C
authors.lastname: Silva
authors.affiliation: Centre of Biological Engineering (CEB), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal. Electronic address: artur@deb.uminho.pt.
authors.forename: Artur
authors.initials: A
authors.lastname: Cavaco-Paulo
mesh_terms: D004339:Drug Compounding / Q000379:methods; D004655:Emulsions / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009821:Oils / Q000737:chemistry*; D011312:Pressure; D011506:Proteins / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000379:methods*; D013010:Sonication / Q000379:methods*
chemical_list: D004655:Emulsions; D009821:Oils; D011506:Proteins
keywords: drug delivery; emulsions; protein; solid-in-oil dispersions; transdermal