title: Roles of microRNA and signaling pathway in osteoarthritis pathogenesis.
abstract: Osteoarthritis (OA) is a common chronic degenerative joint disease, with complicated pathogenic factors and undefined pathogenesis. Various signaling pathways play important roles in OA pathogenesis, including genetic expression, matrix synthesis and degradation, cell proliferation, differentiation, apoptosis, and so on. MicroRNA (miRNA) is a class of non-coding RNA in Eukaryon, regulating genetic expression on the post-transcriptional level. A great number of miRNAs are involved in the development of OA, and are closely associated with different signaling pathways. This article reviews the roles of miRNAs and signaling pathways in OA, looking toward having a better understanding of its pathogenesis mechanisms and providing new therapeutic targets for its treatment.
authors.affiliation: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.affiliation: Zhongnan Hospital, Wuhan University, Wuhan 430071, China.
authors.forename: Yao-yao
authors.initials: YY
authors.lastname: Li
authors.affiliation: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Fu-xing
authors.initials: FX
authors.lastname: Pei
mesh_terms: D019485:Bone Morphogenetic Proteins / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D035683:MicroRNAs / Q000502:physiology*; D016328:NF-kappa B / Q000502:physiology; D010003:Osteoarthritis / Q000209:etiology* / Q000235:genetics; D055758:SOX9 Transcription Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D019485:Bone Morphogenetic Proteins; D035683:MicroRNAs; D016328:NF-kappa B; D055758:SOX9 Transcription Factor; D016212:Transforming Growth Factor beta; D007334:Insulin-Like Growth Factor I
keywords: MicroRNA; Osteoarthritis; Pathogenesis; Signaling pathway