title: Modes of Antiviral Action of Chemical Portions and Constituents from Woad Root Extract against Influenza Virus A FM1.
abstract: Woad root has been used for the prevention of influenza for hundreds of years in many Asian countries. In this study, the antiviral modes of clemastanin B (CB), epigoitrin, phenylpropanoid portion (PEP), and the mixture of phenylpropanoids, alkaloids, and organic acid portions (PEP + ALK + OA) from wood root extract against influenza virus A FM1 were investigated. The results revealed that CB, epigoitrin, PEP, and PEP + ALK + OA exert their anti-influenza activity via inhibiting the virus multiplication, prophylaxis, and blocking the virus attachment. The primary mode of action of PEP and PEP + ALK + OA is the inhibition of virus replication. The inhibitory effect on virus attachment and multiplication is the main modes for epigoitrin. All the compounds or chemical portions from woad root extract tested in this study do not have direct virucidal activity. Our results provided the comprehensive analysis of the antiviral mechanism of wood root extract.
authors.affiliation: Clinical Pharmacy Chamber, Yantai Traditional Chinese Medicine Hospital, Yantai, Shandong 264001, China.
authors.forename: Jia-Hang
authors.initials: JH
authors.lastname: Su
authors.affiliation: Clinical Pharmacy Chamber, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, China.
authors.forename: Rui-Gang
authors.initials: RG
authors.lastname: Diao
authors.affiliation: Heart Disease Division, Yantai Traditional Chinese Medicine Hospital, Shandong 264001, China.
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Lv
authors.affiliation: Department of Laboratory Medicine, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Mou
authors.affiliation: School of Medicine, University of California, San Diego, CA 92103, USA.
authors.forename: Kefeng
authors.initials: K
authors.lastname: Li