title: Hepatitis C Virus Testing and Treatment Among Persons Receiving Buprenorphine in an Office-Based Program for Opioid Use Disorders.
abstract: In the United States, hepatitis C virus (HCV) infection is primarily spread through injection drug use. There is an urgent need to improve access to care for HCV among persons with opioid use disorders who inject drugs. The purpose of our study was to determine the prevalence of HCV, patient characteristics, and receipt of appropriate care in a sample of patients treated with buprenorphine for their opioid use disorders in a primary care setting.
  
  
  
  This study used retrospective clinical data from the electronic medical record. The study population included patients receiving buprenorphine in the Office Based Opioid Treatment (OBOT) clinic within the adult primary medicine clinic at Boston Medical Center between October 2003 and August 2013 who received a conclusive HCV antibody (Ab) test within a year of clinic entry. We compared characteristics by HCV serostatus using Pearson's chi-square and provided numbers/percentages receiving appropriate care.
  
  
  
  The sample comprised 700 patients. Slightly less than half of all patients (n=334, 47.7%) were HCV Ab positive, and were significantly more likely to be older, Hispanic or African American, have diagnoses of post-traumatic stress disorder (PTSD) or bipolar disorder, have prior heroin or cocaine use, and be HIV-infected. Among the 334 HCV Ab positive patients, 226 (67.7%) had detectable HCV ribonucleic acid (RNA) indicating chronic HCV infection; only 5 patients (2.21%) with chronic HCV infection ever initiated treatment.
  
  
  
  Nearly half of patients (47.7%) receiving office-based treatment with buprenorphine for their opioid use disorder had a positive hepatitis C virus antibody screening test although initiation of HCV treatment was nearly non-existent (2.21%).
authors.affiliation: Boston University School of Medicine, 810 Massachusetts Avenue, Boston, MA 02118, USA. Electronic address: kjcarey@bu.edu.
authors.forename: Katelyn J
authors.initials: KJ
authors.lastname: Carey
authors.affiliation: Boston University School of Public Health, 715 Albany Street, Talbot Building, Boston, MA 02118, USA. Electronic address: weih@bu.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Boston University School of Medicine, 810 Massachusetts Avenue, Boston, MA 02118, USA; Boston University School of Public Health, 715 Albany Street, Talbot Building, Boston, MA 02118, USA; Boston Medical Center, 850 Harrison Ave, Dowling 3N, Boston, MA 02118, USA. Electronic address: Benjamin.linas@bmc.org.
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Linas
authors.affiliation: Boston Medical Center, 850 Harrison Ave, Dowling 3N, Boston, MA 02118, USA. Electronic address: tsuij@uw.edu.
authors.forename: Judith I
authors.initials: JI
authors.lastname: Tsui
mesh_terms: D000328:Adult; D001900:Boston / Q000453:epidemiology; D002047:Buprenorphine / Q000008:administration & dosage*; D005260:Female; D006526:Hepatitis C / Q000175:diagnosis* / Q000453:epidemiology / Q000635:transmission; D018937:Hepatitis C Antibodies / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D058850:Opiate Substitution Treatment / Q000379:methods; D009293:Opioid-Related Disorders / Q000150:complications / Q000534:rehabilitation*; D015995:Prevalence; D011320:Primary Health Care; D012189:Retrospective Studies; D012307:Risk Factors; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000534:rehabilitation*
chemical_list: D018937:Hepatitis C Antibodies; D002047:Buprenorphine
keywords: Buprenorphine; HCV screening; HCV treatment; Opioid agonist therapy