title: The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons.
abstract: The arachidonic acid metabolizing enzymes, cyclooxygenase-2 (COX-2) and 5- lipoxygenase (5-LOX), are both highly expressed during the carcinogenesis in colons. Cigarette smoking promotes these carcinogenic processes at the early stage during adenoma formation. In this article, the involvement of COX-2 and 5-LOX, alongside with the dual COX/5-LOX inhibitors in colorectal cancer development is introduced. The co-regulation of 5-LOX and COX-2 in colon cancer growth and its relationship with cigarette smoke and hyaluronic acid-CD44v6 is also described. It is envisaged that dual inhibition of 5-LOX/COX could be the most promising therapeutic option for the treatment of colorectal cancer in humans.
authors.forename: J
authors.initials: J
authors.lastname: Shen
authors.forename: W X
authors.initials: WX
authors.lastname: Li
authors.forename: Z G
authors.initials: ZG
authors.lastname: Xiao
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: M X
authors.initials: MX
authors.lastname: Li
authors.forename: L F
authors.initials: LF
authors.lastname: Li
authors.forename: W
authors.initials: W
authors.lastname: Hu
authors.forename: L
authors.initials: L
authors.lastname: Lu
authors.forename: F
authors.initials: F
authors.lastname: Boudreau
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. chcho@cuhk.edu.hk.
authors.forename: C H
authors.initials: CH
authors.lastname: Cho
mesh_terms: D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000235:genetics / Q000378:metabolism*; D063646:Carcinogenesis / Q000235:genetics*; D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D012907:Smoking
chemical_list: D001094:Arachidonate 5-Lipoxygenase; D051546:Cyclooxygenase 2