title: Alendronate conjugated nanoparticles for calcification targeting.
abstract: In this article, the synthesis of a novel calcification-targeting nanoparticle (NP) is reported, which is realized through dopamine self-polymerization on the poly(lactic-co-glycolic acid) (PLGA) particle surface and subsequent alendronate conjugation. Cell viability and proliferation tests confirmed that such particle has low cytotoxicity and good biocompatibility. Experiments were designed to observe whether the synthesized NPs can pass through an obstructive hydrogel and directly bind themselves to hydroxyapatite (HA) NPs (mimicking calcified spots) and HA porous scaffolds (mimicking calcified tissues); and the result was positive, indicating ingenious targeting of NPs on calcifications. The calcification-targeting NPs are expected to be with promising applications on calcification-related disease diagnoses and therapies.
authors.affiliation: National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, China; Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Nanying
authors.initials: N
authors.lastname: Li
authors.affiliation: National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, China; Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Juqing
authors.initials: J
authors.lastname: Song
authors.affiliation: National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, China; Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Guanglin
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. Electronic address: mrshixuetao@gmail.com.
authors.forename: Xuetao
authors.initials: X
authors.lastname: Shi
authors.affiliation: National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, China. Electronic address: imwangyj@163.com.
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D019386:Alendronate / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D050071:Bone Density Conservation Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D002113:Calcification, Physiologic; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004298:Dopamine / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D017886:Durapatite / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D051379:Mice; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism; D010316:Particle Size; D010539:Permeability; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D058105:Polymerization
chemical_list: D050071:Bone Density Conservation Agents; D004337:Drug Carriers; D020100:Hydrogels; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D017886:Durapatite; D004298:Dopamine; D019386:Alendronate
keywords: Calcification-targeting; Dopamine; Nanoparticle; Poly(lactic-co-glycolic acid)