title: Adhesive systems under fissure sealants: yes or no?: A systematic review and meta-analysis.
abstract: The authors of this systematic review and meta-analysis had 2 aims: to evaluate fissure sealant retention with and without the use of an adhesive system and to compare fissure sealant retention using etch-and-rinse adhesive systems versus self-etching adhesive systems.
  
  
  
  The authors conducted a literature search (all articles published through November 1, 2015) to identify studies for inclusion in this systematic review. They assessed the quality of the evidence provided using the modified Jadad scale and performed meta-analyses using a random-effects model.
  
  
  
  The authors considered 12 studies that met the inclusion criteria for the systematic review. In addition, they used 5 of 9 studies related to the first part of the study and 3 of 4 studies related to the second part of the study that met the inclusion criteria for meta-analysis. In the analysis of the first part of the systematic review, the authors found that adhesive systems had a significant positive effect on fissure sealant (odds ratio, 3.294; 95% confidence interval, 1.292-8.401; P = .013). In the analysis of the second part of the systematic review, the authors found that etch-and-rinse adhesives were superior to self-etching adhesives in the fissure sealant procedure (odds ratio, 14.569; 95% confidence interval, 2.616-81.131; P = .002).
  
  
  
  The use of adhesive systems beneath fissure sealants can increase the retention of fissure sealants. Also, when adhesive systems are used with fissure sealants, etch-and-rinse systems are preferable.
authors.forename: Ali
authors.initials: A
authors.lastname: Bagherian
authors.forename: Alireza
authors.initials: A
authors.lastname: Sarraf Shirazi
authors.forename: Ramin
authors.initials: R
authors.lastname: Sadeghi
mesh_terms: D001840:Dental Bonding; D003738:Dental Cements; D006801:Humans; D010895:Pit and Fissure Sealants
chemical_list: D003738:Dental Cements; D010895:Pit and Fissure Sealants
keywords: Pit-and-fissure sealants; dentin-bonding agents; meta-analysis; systematic review