title: Redox signaling in the cardiomyocyte: From physiology to failure.
abstract: The specific effect of oxygen and reactive oxygen species (ROS) in mediating post-translational modification of protein targets has emerged as a key mechanism regulating signaling components, a process termed redox signaling. ROS act in the post-translational modification of multiple target proteins including receptors, kinases, phosphatases, ion channels and transcription factors. Both O2 and ROS are major source of electrons in redox reactions in aerobic organisms. Because the heart has the highest O2 consumption among body organs, it is not surprising that redox signaling is central to heart function and pathophysiology. In this article, we review some of the main cardiac redox signaling pathways and their roles in the cardiomyocyte and in heart failure, with particular focus on the specific molecular targets of ROS in the heart.
authors.affiliation: King's College London British Heart Foundation Centre of Excellence, Cardiovascular Division, London, UK.
authors.forename: Celio X C
authors.initials: CX
authors.lastname: Santos
authors.affiliation: King's College London British Heart Foundation Centre of Excellence, Cardiovascular Division, London, UK.
authors.forename: Sadaf
authors.initials: S
authors.lastname: Raza
authors.affiliation: King's College London British Heart Foundation Centre of Excellence, Cardiovascular Division, London, UK. Electronic address: ajay.shah@kcl.c.uk.
authors.forename: Ajay M
authors.initials: AM
authors.lastname: Shah
mesh_terms: D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D032383:Myocytes, Cardiac / Q000473:pathology / Q000502:physiology*; D010084:Oxidation-Reduction; D011499:Protein Processing, Post-Translational; D017382:Reactive Oxygen Species; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species
keywords: Heart failure; NADPH oxidase; Reactive oxygen species; Redox signaling