title: Mutations of TP53 gene in adult acute lymphoblastic leukemia at diagnosis do not affect the achievement of hematologic response but correlate with early relapse and very poor survival.
authors.affiliation: Hematology and Bone Marrow Transplant Unit of Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Salmoiraghi
authors.affiliation: Hematology and Bone Marrow Transplant Unit of Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Marie Lorena Guinea
authors.initials: ML
authors.lastname: Montalvo
authors.affiliation: Hematology and Bone Marrow Transplant Unit of Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Greta
authors.initials: G
authors.lastname: Ubiali
authors.affiliation: Hematology and Bone Marrow Transplant Unit of Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Tosi
authors.affiliation: Hematology and Bone Marrow Transplant Unit of Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Peruta
authors.affiliation: Hematology and Bone Marrow Transplant Unit of Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Pamela
authors.initials: P
authors.lastname: Zanghi
authors.affiliation: Hematology and Bone Marrow Transplant Unit of Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Oldani
authors.affiliation: Hematology and Bone Marrow Transplant Unit of Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Boschini
authors.affiliation: Personalized Healthcare and Biomarkers, Innovative Medicines and Early Development, AstraZeneca, Cambridge, UK.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kohlmann
authors.affiliation: Centro Ricerche Tettamanti, Clinica Pediatrica Università Milano-Bicocca, Ospedale San Gerardo, Monza, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bungaro
authors.affiliation: Hematology and Bone Marrow Transplant Unit of Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Tamara
authors.initials: T
authors.lastname: Intermesoli
authors.affiliation: Divisione di Ematologia e Trapianto di Midollo Osseo, Ospedale San Gerardo, Monza, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Terruzzi
authors.affiliation: Ematologia e Centro Trapianti, Ospedale Oncologico di Riferimento Regionale "Armando Businco", Azienda Ospedaliera "Brotzu", Cagliari, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Angelucci
authors.affiliation: Ematologia e Centro Trapianti di Midollo Osseo, Ospedale Centrale, Bolzano, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Cavattoni
authors.affiliation: Hematology, IRCCS San Raffaele Scientific Institute, Milano, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Ciceri
authors.affiliation: Hematology, Ospedale dell'Angelo, Mestre-Venezia, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Bassan
authors.affiliation: Dipartimento Scienze Cliniche e di Comunità, University of Milan, Italy Hematology and Bone Marrow Transplant Unit of Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy arambaldi@asst-pg23.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rambaldi
authors.affiliation: Hematology and Bone Marrow Transplant Unit of Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Orietta
authors.initials: O
authors.lastname: Spinelli
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000628:therapy; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53
keywords: TP53 mutations; acute lymphoblastic leukemia; early relapse; survival