title: Metabolism Is Central to Tolerogenic Dendritic Cell Function.
abstract: Immunological tolerance is a fundamental tenant of immune homeostasis and overall health. Self-tolerance is a critical component of the immune system that allows for the recognition of self, resulting in hyporeactivity instead of immunogenicity. Dendritic cells are central to the establishment of dominant immune tolerance through the secretion of immunosuppressive cytokines and regulatory polarization of T cells. Cellular metabolism holds the key to determining DC immunogenic or tolerogenic cell fate. Recent studies have demonstrated that dendritic cell maturation leads to a shift toward a glycolytic metabolic state and preferred use of glucose as a carbon source. In contrast, tolerogenic dendritic cells favor oxidative phosphorylation and fatty acid oxidation. This dichotomous metabolic reprogramming of dendritic cells drives differential cellular function and plays a role in pathologies, such as autoimmune disease. Pharmacological alterations in metabolism have promising therapeutic potential.
authors.affiliation: Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673.
authors.forename: Wen Jing
authors.initials: WJ
authors.lastname: Sim
authors.affiliation: Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673.
authors.forename: Patricia Jennifer
authors.initials: PJ
authors.lastname: Ahl
authors.affiliation: Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673; Institute of Biomedical Studies, Baylor University, Waco, TX 76712, USA.
authors.forename: John Edward
authors.initials: JE
authors.lastname: Connolly
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000378:metabolism* / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology; D010085:Oxidative Phosphorylation
chemical_list: D005227:Fatty Acids