title: The Effects of One-Anastomosis Gastric Bypass on Glucose Metabolism in Goto-Kakizaki Rats.
abstract: The improvement in glucose metabolism after bariatric surgery is well established. The aim of this study was to investigate the hormones and glycemic control in diabetes after a one-anastomosis gastric bypass (OAGB) variant in an animal model of non-obese type 2 diabetes mellitus.
  
  
  
  Thirty-six Goto-Kakizaki rats were randomly assigned to undergo one of the following procedures: OAGB (18 rats) or sham intervention (18 rats). Each group was subdivided into three additional groups according to the time of surgery (early-12 weeks; intermediate-16 weeks; and late-20 weeks). Weight, fasting glycemia, glucose tolerance test (OGTT), and hormone levels (glucagon, insulin, glucagon-like peptide-1 [GLP-1], and glucose-dependent insulinotropic peptide [GIP]) were measured.
  
  
  
  All rats maintained their weight. The OGTT showed a significant improvement in glycemic levels in rats with OAGB in all time groups (p < 0.002, for all groups at 60 min). Insulin levels decreased significantly in all animals with OAGB, but glucagon levels increased (glucagon paradoxical response). GLP-1 and GIP increased in rats with OAGB at all times, but was only statistically significant in the early surgery group of GLP-1 (p < 0.005).
  
  
  
  OAGB in a non-obese diabetic rat model improves glycemic control, with a significant decrease in glucose and insulin levels. This reduction without weight loss suggests a surgically induced enhancement of pancreatic function. It appears that this improvement occurs, although the GLP-1 levels were significantly increased only in the early stages. The paradoxical response of glucagon should be further evaluated.
authors.affiliation: Universidad Miguel Hernandez de Elche, San Juan de Alicante, Spain. loreazubiaga@gmail.com.
authors.forename: Lorea
authors.initials: L
authors.lastname: Zubiaga
authors.affiliation: Universidad Miguel Hernandez de Elche, San Juan de Alicante, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Abad
authors.affiliation: Hospital Universitario de Mostoles, Madrid, Spain.
authors.forename: Jaime
authors.initials: J
authors.lastname: Ruiz-Tovar
authors.affiliation: Universidad Miguel Hernandez de Elche, San Juan de Alicante, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Enriquez
authors.affiliation: Hospital Universitario Virgen de Arrixaca, Murcia, Spain.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Vílchez
authors.affiliation: Hospital Universitario Virgen de Arrixaca, Murcia, Spain.
authors.forename: Mireia
authors.initials: M
authors.lastname: Calzada
authors.affiliation: Universidad Miguel Hernandez de Elche, San Juan de Alicante, Spain.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Pérez De Gracia
authors.affiliation: International Bariatric Club, Founding Editor Obesity Surgery, Toronto, Canada.
authors.forename: Mervyn
authors.initials: M
authors.lastname: Deitel
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000601:surgery*; D004195:Disease Models, Animal; D015390:Gastric Bypass / Q000379:methods*; D006728:Hormones / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose; D006728:Hormones
keywords: Bariatric surgery; Goto-Kakizaki rat; Mini-gastric bypass; Non-obese model; One-anastomosis gastric bypass; Type 2 diabetes mellitus