title: Menstrual cyclicity post OC withdrawal in PCOS: Use of non-hormonal options.
abstract: There is no data on menstrual cyclicity post oral contraceptive (OC) withdrawal with nonhormonal options in PCOS patients. OC could affect obesity, insulin and gonadotropins factors integral to pathogenesis of PCOS, thereby adversely affecting the HPG axis. Menstrual cycles of PCOS patients were retrospectively studied post OCP. Patients developing regular versus irregular cycles post OC were compared. Forty-eight PCOS patients were followed for an average of 1.9 years post OC. Thirty-six (75%) achieved regular cycles over a period of one year with other nonhormonal options like spironolactone and metformin. Seven patients required no treatment. Patients who continued to have irregular cycles had a longer pre OC cycle length (p < 0.01) and a greater duration of menstrual irregularity (p < 0.02), though age, BMI and hormones were similar in the two groups. In conclusion, spironolactone and metformin are effective nonhormonal options for regular periods post OC. Around 15% PCOS may not require any treatment post OC.
authors.affiliation: a Department of Endocrinology and.
authors.forename: Bindu
authors.initials: B
authors.lastname: Kulshreshtha
authors.affiliation: a Department of Endocrinology and.
authors.forename: Arpita
authors.initials: A
authors.lastname: Arora
authors.affiliation: a Department of Endocrinology and.
authors.forename: Isha
authors.initials: I
authors.lastname: Pahuja
authors.affiliation: b Department of Biochemistry , PGIMER, Dr RML Hospital , Delhi, India.
authors.forename: Neera
authors.initials: N
authors.lastname: Sharma
authors.affiliation: a Department of Endocrinology and.
authors.forename: Shubhi
authors.initials: S
authors.lastname: Pant
mesh_terms: D000293:Adolescent; D000328:Adult; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008597:Menstrual Cycle / Q000187:drug effects*; D008599:Menstruation Disturbances / Q000188:drug therapy* / Q000209:etiology; D008687:Metformin / Q000627:therapeutic use*; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D012189:Retrospective Studies; D013148:Spironolactone / Q000627:therapeutic use*; D028761:Withholding Treatment; D055815:Young Adult
chemical_list: D003278:Contraceptives, Oral, Hormonal; D007004:Hypoglycemic Agents; D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; D008687:Metformin
keywords: OC withdrawal; Resumption; menstrual cycles; oral contraceptive withdrawal; periods; post OCP