title: Hallmarks of Tissue-Resident Lymphocytes.
abstract: Although they are classically viewed as continuously recirculating through the lymphoid organs and blood, lymphocytes also establish residency in non-lymphoid tissues, most prominently at barrier sites, including the mucosal surfaces and skin. These specialized tissue-resident lymphocyte subsets span the innate-adaptive continuum and include innate lymphoid cells (ILCs), unconventional T cells (e.g., NKT, MAIT, γδ T cells, and CD8αα(+) IELs), and tissue-resident memory T (T(RM)) cells. Although these diverse cell types differ in the particulars of their biology, they nonetheless exhibit important shared features, including a role in the preservation of tissue integrity and function during homeostasis, infection, and non-infectious perturbations. In this Review, we discuss the hallmarks of tissue-resident innate, innate-like, and adaptive lymphocytes, as well as their potential functions in non-lymphoid organs.
authors.affiliation: Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, 417 East 68(th) Street, New York, NY 10065, USA. Electronic address: xif2003@med.cornell.edu.
authors.forename: Xiying
authors.initials: X
authors.lastname: Fan
authors.affiliation: Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, 417 East 68(th) Street, New York, NY 10065, USA; Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center, 417 East 68(th) Street, New York, NY 10065, USA. Electronic address: rudenska@mskcc.org.
authors.forename: Alexander Y
authors.initials: AY
authors.lastname: Rudensky
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D007239:Infections / Q000276:immunology; D008214:Lymphocytes / Q000145:classification / Q000166:cytology* / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology