title: Long noncoding RNAs and atherosclerosis.
abstract: Atherosclerosis is universally recognized as a chronic lipid-induced inflammation of the vessel wall in response to dyslipidemia and haemodynamic stress involving dysfunction and activation of resident vascular cells as well as infiltration of leukocytes. As members of nonprotein-coding RNAs, the long noncoding RNAs (lncRNAs) are implicated in various biological processes. Accumulating evidences suggest that lncRNAs regulate the function of vascular wall, activation of macrophages, lipid metabolism and immune response. Here, we review the effects of lncRNAs on the progress of atherosclerosis.
authors.affiliation: Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, Hubei Province, China; Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, Hubei Province, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, Hubei Province, China; Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, Hubei Province, China. Electronic address: dingjiawang@medmail.com.cn.
authors.forename: Jia-wang
authors.initials: JW
authors.lastname: Ding
authors.affiliation: Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, Hubei Province, China; Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, Hubei Province, China.
authors.forename: Xin-an
authors.initials: XA
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, Hubei Province, China; Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, Hubei Province, China.
authors.forename: Xia-xia
authors.initials: XX
authors.lastname: Zheng
mesh_terms: D000818:Animals; D017209:Apoptosis; D050197:Atherosclerosis / Q000235:genetics*; D001786:Blood Glucose / Q000032:analysis; D002465:Cell Movement; D049109:Cell Proliferation; D016922:Cellular Senescence; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D006706:Homeostasis; D006801:Humans; D007107:Immune System; D007249:Inflammation; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood / Q000737:chemistry; D008264:Macrophages / Q000378:metabolism; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D008055:Lipids; D062085:RNA, Long Noncoding; D002784:Cholesterol
keywords: Atherosclerosis; Lipid; Long noncoding RNAs; Vascular function; Vascular inflammation