title: Complete genome sequence of Acinetobacter baumannii XH386 (ST208), a multi-drug resistant bacteria isolated from pediatric hospital in China.
abstract: Acinetobacter baumannii is an important bacterium that emerged as a significant nosocomial pathogen worldwide. The rise of A. baumannii was due to its multi-drug resistance (MDR), while it was difficult to treat multi-drug resistant A. baumannii with antibiotics, especially in pediatric patients for the therapeutic options with antibiotics were quite limited in pediatric patients. A. baumannii ST208 was identified as predominant sequence type of carbapenem resistant A. baumannii in the United States and China. As we knew, there was no complete genome sequence reproted for A. baumannii ST208, although several whole genome shotgun sequences had been reported. Here, we sequenced the 4087-kilobase (kb) chromosome and 112-kb plasmid of A. baumannii XH386 (ST208), which was isolated from a pediatric hospital in China. The genome of A. baumannii XH386 contained 3968 protein-coding genes and 94 RNA-only encoding genes. Genomic analysis and Minimum inhibitory concentration assay showed that A. baumannii XH386 was multi-drug resistant strain, which showed resistance to most of antibiotics, except for tigecycline. The data may be accessed via the GenBank accession number CP010779 and CP010780.
authors.affiliation: The Children's Hospital, College of Medicine, Zhejiang University, 57 Zhugan Lane, Yanan Road, Hangzhou 310003, Zhejiang Province, People's Republic of China.
authors.forename: Youhong
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, People's Republic of China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Quan
authors.affiliation: Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, People's Republic of China.
authors.forename: Xiaoting
authors.initials: X
authors.lastname: Hua
authors.affiliation: Institute for Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, People's Republic of China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, People's Republic of China.
authors.forename: Xi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, People's Republic of China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Wang
authors.affiliation: Clinical Laboratory, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, People's Republic of China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Ruan
authors.affiliation: Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, Ministry of Education, Children's Hospital, Zhejiang University, School of Medicine, Hangzhou 310003, People's Republic of China.
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Shang
authors.affiliation: Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, People's Republic of China.
authors.forename: Yunsong
authors.initials: Y
authors.lastname: Yu
keywords: Acinetobacter baumannii; Multi-drug resistance; Paediatric