title: Acute oral toxicity test of chemical compounds in silkworms.
abstract: This study performed an acute oral toxicity test of 59 compounds in silkworms. These compounds are listed in OECD guidelines as standard substances for a cytotoxicity test, and median lethal dose (LD(50)) werecalculated for each compound. Acute oral LD(50) values in mammals are listed in OECD guidelines and acute oral LD(50) values in silkworms were determined in this study. R(2) for the correlation between LD(50) values in mammals and LD(50) values in silkworms was 0.66. In addition, the acute oral toxicity test in silkworms was performed by two different facilities, and test results from the facilities were highly reproducible. These findings suggest that an acute oral toxicity test in silkworms is a useful way to evaluate the toxicity of compounds in mammals.
authors.affiliation: Genome Pharmaceuticals Institute Co., Ltd.
authors.forename: Kimihito
authors.initials: K
authors.lastname: Usui
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishida
authors.forename: Takuya
authors.initials: T
authors.lastname: Sugita
authors.forename: Takuro
authors.initials: T
authors.lastname: Ueki
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Okumura
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sekimizu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D012831:Bombyx / Q000187:drug effects* / Q000196:embryology; D006801:Humans; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D023421:Models, Animal; D015588:Observer Variation; D015203:Reproducibility of Results; D018570:Risk Assessment; D013045:Species Specificity; D023382:Toxicity Tests, Acute / Q000379:methods*