title: IL24 and its Receptors Regulate Growth and Migration of Pancreatic Cancer Cells and Are Potential Biomarkers for IL24 Molecular Therapy.
abstract: BACKGROUND
  Pancreatic cancer is hard to diagnose and treat due to its asymptomatic development and early metastasis. Supplementary therapy including molecular targeted therapy is needed to improve the outcome of pancreatic cancer. The significance of interleukin 24 (IL24) and its receptors in pancreatic cancer were investigated in this study.
  
  
  METHODS
  Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was carried out in 200 patient samples of pancreatic cancer. Transcript and protein expression were investigated in pancreatic cancer cells. Impact of IL24 recombinant protein on cell functions was examined.
  
  
  RESULTS
  High IL20R1 transcript expression was related to early T stage, and advanced N, and M stage. They collectively correlated with the survival of the patients. Treatment with IL24 inhibited cell growth, but its impact on migration varied depending on protein concentration.
  
  
  CONCLUSIONS
  IL20R1 correlated with prognosis of patients with pancreatic cancer, and mediates pancreatic cancer cell growth and migration. It may be a potential biomarker for IL24 molecular-targeted therapy.
authors.affiliation: Cardiff China Medical Research Collaborative, Cardiff-Peking Cancer Institute, Cardiff University School of Medicine, Cardiff, U.K. Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital&Institute, Beijing, P.R. China.
authors.forename: Yongning
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Cardiff China Medical Research Collaborative, Cardiff-Peking Cancer Institute, Cardiff University School of Medicine, Cardiff, U.K.
authors.forename: K E
authors.initials: KE
authors.lastname: Ji
authors.affiliation: Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital&Institute, Beijing, P.R. China.
authors.forename: Jiafu
authors.initials: J
authors.lastname: Ji
authors.affiliation: Department of Hepato-Pancreatic Biliary Surgery, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, P.R. China.
authors.forename: Chunyi
authors.initials: C
authors.lastname: Hao
authors.affiliation: Cardiff China Medical Research Collaborative, Cardiff-Peking Cancer Institute, Cardiff University School of Medicine, Cardiff, U.K.
authors.forename: Lin
authors.initials: L
authors.lastname: Ye
authors.affiliation: Cardiff China Medical Research Collaborative, Cardiff-Peking Cancer Institute, Cardiff University School of Medicine, Cardiff, U.K.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Sanders
authors.affiliation: Cardiff China Medical Research Collaborative, Cardiff-Peking Cancer Institute, Cardiff University School of Medicine, Cardiff, U.K. Jiangw@cf.ac.uk.
authors.forename: Wen G
authors.initials: WG
authors.lastname: Jiang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007378:Interleukins / Q000494:pharmacology*; D053208:Kaplan-Meier Estimate; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D018123:Receptors, Interleukin / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D013997:Time Factors; D000099180:Interleukin-24
chemical_list: D000970:Antineoplastic Agents; D007378:Interleukins; D018123:Receptors, Interleukin; D011994:Recombinant Proteins; D000099180:Interleukin-24; C492510:interleukin-20 receptor
keywords: IL24; IL24 receptor; growth; migration; pancreatic cancer