title: Positive linear dose-response relationships, but no J-shaped relationship, between drinking habits and estimated glomerular filtration rate in middle-aged Japanese men.
abstract: The relationship between drinking frequency and amount of alcohol consumption (i.e., drinking habits) and the risk of chronic kidney disease (CKD) remains unclear. We aimed to clarify either a linear or J-shaped dose-response relationship between drinking habits and estimated glomerular filtration rate (eGFR) as a biomarker for identifying individuals at high risk of CKD. In a large-scale cross-sectional study, 403 men and 121 women with an eGFR of 30-60 mL/min per 1.73 m(2) were defined as cases, and 1209 men and 363 women with ≥60 mL/min/1.73 m(2) were randomly extracted as controls (one case subject was matched with three control subjects, matched according to age and season of data collection). We calculated multivariate-adjusted CKD risk and the corresponding mean eGFR according to drinking habits. In men, negative and positive linear relationships with drinking habits were found for CKD risk and mean eGFR (p < 0.001 for all linear terms), respectively, but there were no corresponding J-shaped relationships (not significant for all quadratic terms). In regard to the mean eGFR, however, positive linear relationships were only shown in men in the highest eGFR quartile (p < 0.05 and p < 0.01 for drinking frequency and amount of alcohol consumption, respectively). In women, no association was found. Regarding each drinking habit, we found a positive linear dose-response relationship to eGFR in middle-aged men with an eGFR ≥30 mL/min/1.73 m(2).
authors.affiliation: Laboratory of Public Health, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Shirai
authors.affiliation: Laboratory of Public Health, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan. Electronic address: kuriki@u-shizuoka-ken.ac.jp.
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Kuriki
authors.affiliation: Laboratory of Public Health, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Endoh
authors.affiliation: Laboratory of Nutritional Physiology, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Yada52-1, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Miyauchi
authors.affiliation: SBS Shizuoka Health Promotion Center, Shizuoka, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Kasezawa
authors.affiliation: SBS Shizuoka Health Promotion Center, Shizuoka, Japan.
authors.forename: Kazushige
authors.initials: K
authors.lastname: Tohyama
authors.affiliation: Laboratory of Nutritional Physiology, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Yada52-1, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.
authors.forename: Toshinao
authors.initials: T
authors.lastname: Goda
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects* / Q000502:physiology; D006184:Habits; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000453:epidemiology*; D011795:Surveys and Questionnaires
chemical_list: D000431:Ethanol
keywords: Alcohol drinking; Chronic kidney disease; Dose-response relationship; Epidemiology; Estimated glomerular filtration rate; Ethanol consumption