title: Role of Proangiogenic Factors in Immunopathogenesis of Multiple Sclerosis.
abstract: Angiogenesis is a complex and balanced process in which new blood vessels form from preexisting ones by sprouting, splitting, growth and remodeling. This phenomenon plays a vital role in many physiological and pathological processes. However, the disturbance in physiological process can play a role in pathogenesis of some chronic inflammatory diseases, including multiple sclerosis (MS) in human and its animal model. Although the relation between abnormal blood vessels and MS lesions was established in previous studies, but the role of pathological angiogenesis remains unclear. In this study, the link between proangiogenic factors and multiple sclerosis pathogenesis was examined by conducting a systemic review. Thus we searched the English medical literature via PubMed, ISI web of knowledge, Medline and virtual health library (VHL) databases. In this review, we describe direct and indirect roles of some proangiogenic factors in MS pathogenesis and report the association of these factors with pathological and inflammatory angiogenesis.
authors.affiliation: Department of Immunology, School of Public Health, Tehran University of Medical Sciences-International Campus, Tehran, Iran AND Department of Immunology, Faculty of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
authors.forename: Kabir Magaji
authors.initials: KM
authors.lastname: Hamid
authors.affiliation: Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Mirshafiey
mesh_terms: D042501:Angiogenic Proteins / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D001812:Blood-Brain Barrier / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002490:Central Nervous System / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic; D015398:Signal Transduction
chemical_list: D042501:Angiogenic Proteins; D018836:Inflammation Mediators
keywords: Angiogenesis inducing agent; Blood-brain barrier; Endothelial cells; Experimental autoimmune encephalomyelitis; Extracellular matrix; Matrix metalloproteinase; Multiple sclerosis; Vascular endothelial growth factor A