title: Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer.
abstract: Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications.
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA, 98195, USA. eddiejfox@gmail.com.
authors.forename: Edward J
authors.identifier: http://orcid.org/0000-0002-3740-651X
authors.initials: EJ
authors.lastname: Fox
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA, 98195, USA.|Department of Medicine, Division of Oncology, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Jesse J
authors.initials: JJ
authors.lastname: Salk
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA, 98195, USA.|Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Loeb
mesh_terms: D000375:Aging / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D009154:Mutation; D059645:Mutation Rate; D009369:Neoplasms / Q000235:genetics*