title: Resveratrol and Alzheimer's Disease: Mechanistic Insights.
abstract: Alzheimer's disease (AD) is the leading cause of dementia in the elderly and is characterized by progressive cognitive and memory deficits. The pathological hallmarks of AD include extracellular senile plaques and intracellular neurofibrillary tangles. Although several mechanisms have been used to explain the underlying pathogenesis of AD, current treatment regimens remain inadequate. The neuroprotective effects of the polyphenolic stilbene resveratrol (3,5,4'-trihydroxy-trans-stilbene) have been investigated in several in vitro and in vivo models of AD. The current review discusses the multiple potential mechanisms of action of resveratrol on the pathobiology of AD. Moreover, due to the limited pharmacokinetic parameters of resveratrol, multiple strategies aimed at increasing the bioavailability of resveratrol have also been addressed.
authors.affiliation: Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad, 44000, Pakistan. touqeer.aahmed@gmail.com.
authors.forename: Touqeer
authors.initials: T
authors.lastname: Ahmed
authors.affiliation: Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad, 44000, Pakistan.
authors.forename: Sehrish
authors.initials: S
authors.lastname: Javed
authors.affiliation: Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad, 44000, Pakistan.
authors.forename: Sana
authors.initials: S
authors.lastname: Javed
authors.affiliation: Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad, 44000, Pakistan.
authors.forename: Ameema
authors.initials: A
authors.lastname: Tariq
authors.affiliation: Department of Molecular Biology, Institute 'Ruđer Bošković', Bijenička c. 54, P.O. Box 180, 10000, Zagreb, Croatia.
authors.forename: Dunja
authors.initials: D
authors.lastname: Šamec
authors.affiliation: Experimental Laboratory, Research Unit, Son Llàtzer Hospital, IUNICS, Ctra. Manacor km 4, 07198, Palma de Mallorca, Balearic Islands, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Tejada
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19395-5487, Tehran, Iran.
authors.forename: Seyed Fazel
authors.initials: SF
authors.lastname: Nabavi
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
authors.forename: Nady
authors.initials: N
authors.lastname: Braidy
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19395-5487, Tehran, Iran. Nabavi208@gmail.com.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D001343:Autophagy / Q000187:drug effects; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009410:Nerve Degeneration / Q000188:drug therapy / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D000077185:Resveratrol; D013267:Stilbenes / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D013267:Stilbenes; D000077185:Resveratrol
keywords: Alzheimer’s disease; Amyloid; Neurodegeneration; Neuroinflammation; Resveratrol