title: Scanning, non-contact, hybrid broadband diffuse optical spectroscopy and diffuse correlation spectroscopy system.
abstract: A scanning system for small animal imaging using non-contact, hybrid broadband diffuse optical spectroscopy (ncDOS) and diffuse correlation spectroscopy (ncDCS) is presented. The ncDOS uses a two-dimensional spectrophotometer retrieving broadband (610-900 nm) spectral information from up to fifty-seven source-detector distances between 2 and 5 mm. The ncDCS data is simultaneously acquired from four source-detector pairs. The sample is scanned in two dimensions while tracking variations in height. The system has been validated with liquid phantoms, demonstrated in vivo on a human fingertip during an arm cuff occlusion and on a group of mice with xenoimplanted renal cell carcinoma.
authors.affiliation: ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Sciences and Technology, 08860, Castelldefels (Barcelona), Spain.
authors.forename: Johannes D
authors.initials: JD
authors.lastname: Johansson
authors.affiliation: ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Sciences and Technology, 08860, Castelldefels (Barcelona), Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Mireles
authors.affiliation: ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Sciences and Technology, 08860, Castelldefels (Barcelona), Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Morales-Dalmau
authors.affiliation: ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Sciences and Technology, 08860, Castelldefels (Barcelona), Spain.
authors.forename: Parisa
authors.initials: P
authors.lastname: Farzam
authors.affiliation: Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology, Bellvitge Biomedical Research Institute-IDIBELL, 08908, L'Hospitalet de Llobregat (Barcelona), Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Martínez-Lozano
authors.affiliation: Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology, Bellvitge Biomedical Research Institute-IDIBELL, 08908, L'Hospitalet de Llobregat (Barcelona), Spain.
authors.forename: Oriol
authors.initials: O
authors.lastname: Casanovas
authors.affiliation: ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Sciences and Technology, 08860, Castelldefels (Barcelona), Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08015 Barcelona, Spain.
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
keywords: (170.0110) Imaging systems; (170.0170) Medical optics and biotechnology