title: Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft.
abstract: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a clinico-pathologic entity, the recurrence of which in the renal allograft has only recently been described. A 55-year-old male presented with rapid deterioration of renal function. Light microscopy showed membranoproliferative glomerulonephritis with kappa light chain restriction and only one sub-class of IgG. He subsequently underwent renal transplant. Two months later, he developed acute graft dysfunction. Renal biopsy showed a recurrence of the disease. Work up for multiple myeloma was positive. Membranoproliferative pattern of injury in the posttransplant setting has a wide range of differential diagnosis, PGNMID being one of them.
authors.affiliation: Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Tewari
authors.forename: Kusum
authors.initials: K
authors.lastname: Joshi
authors.forename: Ashwani
authors.initials: A
authors.lastname: Kumar
authors.forename: C S
authors.initials: CS
authors.lastname: Rayat
authors.forename: Rajaram
authors.initials: R
authors.lastname: Iyer
authors.forename: Vinay
authors.initials: V
authors.lastname: Sakhuja
authors.forename: Mukut
authors.initials: M
authors.lastname: Minz
mesh_terms: D064591:Allografts; D000911:Antibodies, Monoclonal / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D005455:Fluorescent Antibody Technique; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis / Q000276:immunology / Q000601:surgery*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D007668:Kidney / Q000276:immunology* / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000276:immunology / Q000601:surgery*; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D007145:Immunoglobulin kappa-Chains