title: Mitochondria-specific conjugated polymer nanoparticles.
abstract: Biodegradable conjugated polymer nanoparticles (CPNs) were prepared for high mitochondrial targeting in live cancer cells. The degradable CPNs are nontoxic and specifically localized to the mitochondria of live tumor cells through macropinocytosis followed by intracellular degradation and trafficking.
authors.affiliation: Department of Chemistry and Biochemistry, Biomolecular Sciences Institute, Florida International University, Miami, Florida 33199, USA. jmoon@fiu.edu.
authors.forename: Megan
authors.initials: M
authors.lastname: Twomey
authors.forename: Eladio
authors.initials: E
authors.lastname: Mendez
authors.forename: Rajesh Kumar
authors.initials: RK
authors.lastname: Manian
authors.forename: Sunwoo
authors.initials: S
authors.lastname: Lee
authors.forename: Joong Ho
authors.initials: JH
authors.lastname: Moon
mesh_terms: D018613:Microscopy, Confocal; D008928:Mitochondria / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry*; D010873:Pinocytosis; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers