title: Information Limited Oligonucleotide Amplification Assay for Affinity-Based, Parallel Detection Studies.
abstract: Molecular communication systems encounter similar constraints as telecommunications. In either case, channel crosstalk at the receiver end will result in information loss that statistical analysis cannot compensate. This is because in any communication channel there is a physical limit to the amount of information that can be transmitted. We present a novel and simple modified end amplification (MEA) technique to generate reduced and defined amounts of specific information in form of short fragments from an oligonucleotide source that also contains unrelated and redundant information. Our method can be a valuable tool to investigate information overflow and channel capacity in biomolecular recognition systems.
authors.affiliation: Institute of Biological Experimental Physics, Saarland University, Saarbrucken, Germany.
authors.forename: Harish
authors.initials: H
authors.lastname: Bokkasam
authors.affiliation: Institute of Biological Experimental Physics, Saarland University, Saarbrucken, Germany.
authors.forename: Albrecht
authors.initials: A
authors.lastname: Ott
mesh_terms: D009841:Oligonucleotides / Q000737:chemistry*; D016133:Polymerase Chain Reaction / Q000379:methods
chemical_list: D009841:Oligonucleotides