title: Expression of C-X-C chemokine receptor type 7 in otorhinolaryngologic neoplasms.
abstract: BACKGROUND
  C-X-C chemokine receptor type 7 (CXCR7) has recently been characterised as a novel receptor for the C-X-C motif chemokine 12 (CXCL12)/stromal cell-derived factor 1-alpha. CXCR7 has been thought to play an important role in the pathogenesis of chronic rhinosinusitis, angiogenesis and tumour metastasis. The present study aimed to examine the expression of CXCR7 in tissue samples of laryngeal cancer and maxillary sinus carcinoma to determine its role in the development of otorhinolaryngologic neoplasms.
  
  
  METHODS
  Samples of otorhinolaryngologic neoplasms were obtained from 17 patients with either nasal polyps (n = 7), laryngeal cancer (n = 5) or maxillary sinus carcinoma (n = 5), and who underwent surgical resection at West China Hospital of Sichuan University. Total RNA was isolated and CXCR7 mRNA expression was examined and quantified by relative real-time reverse transcription polymerase chain reaction. A one-way analysis of variance was performed using SPSS Statistics version 11.0 (SPSS Inc, Chicago, IL, USA) to compare the CXCR7 mRNA levels among the three groups of patients.
  
  
  RESULTS
  All samples tested positive for CXCR7 mRNA. The quantitative results showed that the CXCR7 mRNA levels were highest in laryngeal cancer and lowest in maxillary sinus carcinoma neoplasms, although there was no significant difference among the three samples.
  
  
  CONCLUSIONS
  CXCL12 and its receptor CXCR7 may contribute to eosinophilic inflammation in patients with chronic sinusitis and nasal polyps. Our results also suggest that CXCR7 may play a role in the progression, metastasis and angiogenesis of otorhinolaryngologic tumours.
authors.affiliation: West China Medical School, Department of Gynecology and Obstetrics, West China Second University Hospital, Chengdu, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Tang
authors.affiliation: West China Laboratory of Molecular Genetics, Sichuan University, Chengdu, China.
authors.forename: Qing Jie
authors.initials: QJ
authors.lastname: Xia
authors.affiliation: Department of Otorhinolaryngology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Qiao
authors.affiliation: Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China.
authors.forename: Mingrong
authors.initials: M
authors.lastname: Xi
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D010039:Otorhinolaryngologic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D012334:RNA, Neoplasm / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D054387:Receptors, CXCR / Q000096:biosynthesis / Q000235:genetics*
chemical_list: C501896:ACKR3 protein, human; D014408:Biomarkers, Tumor; D012334:RNA, Neoplasm; D054387:Receptors, CXCR
keywords: CXCR7; laryngeal cancer; maxillary sinus carcinoma; nasal polyposis