title: Direct Asymmetric Reductive Amination for the Synthesis of Chiral β-Arylamines.
abstract: The highly efficient and direct asymmetric reductive amination of arylacetones catalyzed by an iridium complex for the preparation of enantiomerically pure β-arylamines is described. The monodentate phosphoramidite ligand exhibits superb reactivity (TONs of up to 20 000) and enantioselectivity (up to 99 % ee). Additives played important roles in this reductive coupling reaction.
authors.affiliation: Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100, PR China.
authors.forename: Haizhou
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100, PR China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100, PR China. zhoulechem@nwsuaf.edu.cn.
authors.forename: Le
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100, PR China. mxchang@nwsuaf.edu.cn.
authors.forename: Mingxin
authors.initials: M
authors.lastname: Chang
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
keywords: asymmetric catalysis; enantioselectivity; iridium; ligand design; reductions