title: The association between platelet-to-lymphocyte ratio and inflammatory markers with the severity of aortic stenosis.
abstract: OBJECTIVE
  Platelet-to-lymphocyte ratio (PLR) was proposed as a novel indirect marker of inflammation. We aimed to evaluate the relationship between PLR and aortic stenosis (AS).
  
  
  METHODS
  The study population included 453 patients of which 98 patients with severe AS, 206 patients with mild-to-moderate AS and 149 patients as control.
  
  
  RESULTS
  PLR was significantly increased in parallel to the severity of AS (p < 0.001). There was significant positive correlation between PLR and maximum, and mean systolic transaortic gradient (all p < 0.001). Also, PLR was correlated with C-reactive protein and neutrophil-to-lymphocyte ratio (all p < 0.001) and PLR was independently associated with the presence of AS (p < 0.001).
  
  
  CONCLUSIONS
  We found a significant relationship between PLR and AS.
authors.affiliation: Türkiye Yüksek Ihtisas Training & Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Çağrı
authors.initials: Ç
authors.lastname: Yayla
authors.affiliation: Türkiye Yüksek Ihtisas Training & Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Sadık Kadri
authors.initials: SK
authors.lastname: Açikgöz
authors.affiliation: Dışkapı Yıldırım Beyazıt Training & Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Kadriye Gayretli
authors.initials: KG
authors.lastname: Yayla
authors.affiliation: Department of Cardiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Eser
authors.initials: E
authors.lastname: Açikgöz
authors.affiliation: Türkiye Yüksek Ihtisas Training & Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Uğur
authors.initials: U
authors.lastname: Canpolat
authors.affiliation: Türkiye Yüksek Ihtisas Training & Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Kirbaş
authors.affiliation: Türkiye Yüksek Ihtisas Training & Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Öksüz
authors.affiliation: Türkiye Yüksek Ihtisas Training & Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Fırat
authors.initials: F
authors.lastname: Özcan
authors.affiliation: Türkiye Yüksek Ihtisas Training & Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Mehmet Kadri
authors.initials: MK
authors.lastname: Akboğa
authors.affiliation: Türkiye Yüksek Ihtisas Training & Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Topaloğlu
authors.affiliation: Türkiye Yüksek Ihtisas Training & Research Hospital, Cardiology Clinic, Ankara, Turkey.
authors.forename: Dursun
authors.initials: D
authors.lastname: Aras
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000473:pathology*; D001786:Blood Glucose / Q000032:analysis; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D016015:Logistic Models; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology / Q000378:metabolism; D016017:Odds Ratio; D010976:Platelet Count; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D001786:Blood Glucose; D002097:C-Reactive Protein
keywords: aortic stenosis; inflammation; platelet-to-lymphocyte ratio