title: The current progress in understanding the molecular functions and mechanisms of visfatin in osteoarthritis.
abstract: Osteoarthritis, (OA), also known as degenerative arthritis or degenerative joint disease, is the most common form of arthritis, affecting millions of people worldwide. It is a group of mechanical abnormalities involving degradation of the joints and occurs when the protective cartilage (articular cartilage) on the ends of bones such as the knees, hips and fingers abrades over time. It mainly affects the whole joint structure, including the articular cartilage, subchondral bone and synovial tissue. Extensive work has been done in the past decades to investigate the cellular mechanism of this disease. However, to date, it is still poorly understood, and there is no effective treatment. Recently, both in vitro and in vivo studies have confirmed adipokines play critical roles during OA development. Among these, leptin and adiponectin have been well investigated, whereas the effect of the novel adipokine, visfatin, on OA still needs to be revealed. Therefore, in this short review, we will focus on visfatin and summarize the current progress in the research on its role in OA development.
authors.affiliation: Department of Orthopedics, The Second Xiangya Hospital of Central South University, 86 Renmin Middle Rd, Yuhua, Changsha, Hunan, China.
authors.forename: Lele
authors.initials: L
authors.lastname: Liao
authors.affiliation: Department of Orthopedics, The Second Xiangya Hospital of Central South University, 86 Renmin Middle Rd, Yuhua, Changsha, Hunan, China.
authors.forename: Yiyue
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, The Second Xiangya Hospital of Central South University, 86 Renmin Middle Rd, Yuhua, Changsha, Hunan, China. wanchunwang1@163.com.
authors.forename: Wanchun
authors.initials: W
authors.lastname: Wang
mesh_terms: D054392:Adipokines / Q000502:physiology; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D015232:Dinoprostone / Q000502:physiology; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators; D051379:Mice; D020932:Nerve Growth Factor / Q000378:metabolism; D054409:Nicotinamide Phosphoribosyltransferase / Q000502:physiology*; D010003:Osteoarthritis / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism; D056564:Sirtuin 1 / Q000502:physiology; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D054392:Adipokines; D051792:Basic Helix-Loop-Helix Proteins; D015232:Dinoprostone; D048049:Extracellular Signal-Regulated MAP Kinases; D018836:Inflammation Mediators; D020932:Nerve Growth Factor; D054409:Nicotinamide Phosphoribosyltransferase; D056564:Sirtuin 1; D000099162:Endothelial PAS Domain-Containing Protein 1
keywords: Cartilage; Osteoarthritis (OA); Visfatin