title: Intraocular cytokines imbalance in congenital cataract and its impact on posterior capsule opacification.
abstract: BACKGROUND
  Congenital cataract is of particular interest because of the variability of etiologies and the inflammatory reaction that are often observed. The aim of the study was to describe intraocular levels of various inflammation-related cytokines of patients with congenital cataract and to study their correlations with clinical determinants.
  
  
  METHODS
  We followed a cohort of 18 patients (18 eyes) with congenital cataract from a University hospital and measured levels of various inflammation-related cytokines in the aqueous humor of patients with congenital cataract, and compared these levels to those observed in a control group (patients with senile cataract) using multiplex immunoassay. Correlation analysis was used to study the possible correlation between intraocular levels of cytokines and clinical determinants.
  
  
  RESULTS
  Compared with the control group, the group with congenital cataract showed clear and significantly elevated concentrations of inflammatory markers (IL-1β, IL-15, IFN-γ, IL-12, IL-6, IL-5, IL-9, MIP-1α, MCP-1 and IP-10). Postoperative intraocular inflammation and opacification of the posterior capsule seemed to be correlated with preoperative IL-1β, TNF-α and IL-6 levels.
  
  
  CONCLUSIONS
  An inflammatory condition may occur in eyes with congenital cataract. The cytokine profiles are really different than those observed in senile cataract. Moreover, cytokines levels may be of interest to predict posterior capsule opacification and to complete the etiological workup.
authors.affiliation: Ophthalmology and Federation de Medecine Translationnelle de Strasbourg (FMTS), Strasbourg University Hospital, BP 426 - Nouvel Hôpital Civil, Strasbourg, France. arnaud.sauer@chru-strasbourg.fr.|Department of Parasitology, Strasbourg University Hospital, 3 Rue Koeberlé, 67000, Strasbourg, France. arnaud.sauer@chru-strasbourg.fr.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Sauer
authors.affiliation: Ophthalmology and Federation de Medecine Translationnelle de Strasbourg (FMTS), Strasbourg University Hospital, BP 426 - Nouvel Hôpital Civil, Strasbourg, France.
authors.forename: Tristan
authors.initials: T
authors.lastname: Bourcier
authors.affiliation: Ophthalmology and Federation de Medecine Translationnelle de Strasbourg (FMTS), Strasbourg University Hospital, BP 426 - Nouvel Hôpital Civil, Strasbourg, France.
authors.forename: David
authors.initials: D
authors.lastname: Gaucher
authors.affiliation: Department of Parasitology, Strasbourg University Hospital, 3 Rue Koeberlé, 67000, Strasbourg, France.
authors.forename: Ermanno
authors.initials: E
authors.lastname: Candolfi
authors.affiliation: Ophthalmology and Federation de Medecine Translationnelle de Strasbourg (FMTS), Strasbourg University Hospital, BP 426 - Nouvel Hôpital Civil, Strasbourg, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Speeg-Schatz
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D058442:Capsule Opacification / Q000378:metabolism*; D002386:Cataract / Q000151:congenital* / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D007118:Immunoassay; D007223:Infant; D008297:Male; D057852:Posterior Capsule of the Lens / Q000378:metabolism
chemical_list: D016207:Cytokines
keywords: Congenital cataract; Cytokines; Inflammation; Posterior capsule opacification