title: Cytotoxic and Antitumour Studies of Acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone and its Transition Metal Complexes.
abstract: Cytotoxic activities of acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone (L2H) and its seven different metal complexes were studied. Of these, IC50 value of the copper complex was found to be 46 μg/ml. Antitumour studies of this copper complex was carried out using Daltons Lymphoma Ascites cell-induced solid tumour model and Ehrlich's Ascites Carcinoma cell-induced ascites tumour model. Administration of the copper complex at different concentrations (10, 5 and 1 mg/kg b. wt) inhibited the solid tumour development in mice and increased the mean survival rate and the life span of Ascites tumour bearing mice in a concentration dependent manner.
authors.affiliation: Department of Chemistry, University of Calicut, Malappuram-673 635, India.
authors.forename: N P
authors.initials: NP
authors.lastname: Priya
authors.affiliation: Department of Chemistry, University of Calicut, Malappuram-673 635, India.
authors.forename: A P
authors.initials: AP
authors.lastname: Firdous
authors.affiliation: Department of Chemistry, University of Calicut, Malappuram-673 635, India.
authors.forename: R
authors.initials: R
authors.lastname: Jeevana
authors.affiliation: Department of Chemistry, University of Calicut, Malappuram-673 635, India.
authors.forename: K K
authors.initials: KK
authors.lastname: Aravindakshan
keywords: Daltons lymphoma ascites; Ehrlich ascites carcinoma; acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone; cytotoxicity; ligand