title: Popliteal vein compression syndrome pathophysiology and correlation with popliteal compartment pressures.
abstract: OBJECTIVE
  The link between obesity and popliteal vein compression syndrome (PVCS) has been documented, but the pathophysiological mechanism is unclear. The aim of this study is to understand the pathogenesis of PVCS by assessing popliteal compartment pressures (PCP).
  
  
  METHODS
  Twenty-three limbs (15 patients) were included. Eleven limbs were ultrasonically diagnosed with PVCS and underwent popliteal vein decompression. The control group consisted of 12 limbs with functional popliteal artery entrapment. Perioperatively, PCP measurements were obtained. The body mass index (BMI) was calculated and the clinical symptoms were documented (CEAP).
  
  
  RESULTS
  The median BMI for the PVCS group was 32 (range, 26-45.8) compared with 28 (range, 19-31) for the control group (P = .05). In PVCS, the popliteal vein internal diameter was 9.4 mm (range, 8.0-20.0 mm) upon knee flexion, compared with 0 mm (range, 0.0-0.1 mm) upon knee extension. Upon knee flexion, there was no difference in pressure (PVCS 10.0 [range, 4-20] vs control 11.5 [range, 3-22]; P = .95). Upon knee extension, the median PCP in the PVCS group was 53 cm H2O (range, 38-76 cm H2O) compared with 26 cm H2O (range, 17-43 cm H2O) in the control group (P < .001).
  
  
  CONCLUSIONS
  PVCS is associated with high popliteal compartment pressures compared with controls. The pathophysiology of popliteal obstruction, in the absence of anatomical abnormalities, is related to an increase in popliteal compartment pressure while standing due an increase of the popliteal fat pad, related to high BMI.
authors.affiliation: Department of Vascular Surgery, Macquarie University Hospital, North Ryde, New South Wales, Australia; Department of Vascular Surgery, Dalcross Private Hospital, Killara, New South Wales, Australia. Electronic address: Martijn.Dijkstra@gmail.com.
authors.forename: Martijn L
authors.initials: ML
authors.lastname: Dijkstra
authors.affiliation: Australian School of Advance Medicine, Macquarie University, North Ryde, New South Wales, Australia.
authors.forename: Nyan Y
authors.initials: NY
authors.lastname: Khin
authors.affiliation: Department of Vascular Surgery, Royal North Shore Hospital, St. Leonards, New South Wales, Australia.
authors.forename: Shannon D
authors.initials: SD
authors.lastname: Thomas
authors.affiliation: Department of Vascular Surgery, Macquarie University Hospital, North Ryde, New South Wales, Australia; Australian School of Advance Medicine, Macquarie University, North Ryde, New South Wales, Australia; Department of Vascular Surgery, Royal North Shore Hospital, St. Leonards, New South Wales, Australia; Department of Vascular Surgery, Dalcross Private Hospital, Killara, New South Wales, Australia.
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Lane