title: [Experience of the antidepressive therapy with valdoxan (agomelatine) in a psychogeriatric unit of the psychiatric hospital].
abstract: OBJECTIVE
  To assess therapeutic efficacy, tolerability and safety of valdoxan (agomelatine) in the treatment of depression in elderly inpatients of the psychiatric hospital.
  
  
  METHODS
  The study included 20 patients, aged 60 years and older, with depression of varying severity. Patients received valdoxan in standard doses 25-50 mg/day during 42 days.
  
  
  RESULTS
  Valdoxan showed a good balanced profile (in terms of indicators of depression, anxiety and anhedonia) of therapeutic response and tolerability in inpatients with mild to moderate depression. The use of valdoxan led to a significant reduction of depressive disorders and anxiety already in the early period of treatment. The severity of anhedonia decreased to the 14th day of treatment. A significant improvement in cognitive functioning of patients was noted to the end of treatment.
  
  
  CONCLUSIONS
  Valdoxan can be recommended for treatment of mild and moderate depression in inpatients of psychiatric hospitals.
authors.affiliation: Mental Health Research Center, Moscow, Russia.
authors.forename: Ya B
authors.initials: YB
authors.lastname: Kalyn
authors.affiliation: Mental Health Research Center, Moscow, Russia.
authors.forename: T P
authors.initials: TP
authors.lastname: Safarova
authors.affiliation: Mental Health Research Center, Moscow, Russia.
authors.forename: O B
authors.initials: OB
authors.lastname: Yakovleva
authors.affiliation: Mental Health Research Center, Moscow, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Sheshenin
authors.affiliation: Mental Health Research Center, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Kornilov
authors.affiliation: Mental Health Research Center, Moscow, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Shipilova
authors.affiliation: Mental Health Research Center, Moscow, Russia.
authors.forename: S I
authors.initials: SI
authors.lastname: Gavrilova
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D005852:Geriatric Psychiatry; D006299:Health Services for the Aged; D006778:Hospitals, Psychiatric; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000928:Antidepressive Agents; C084711:agomelatine; D009281:Naphthalenes