title: Silence of the ROS.
abstract: Reactive oxygen species (ROS) are generated during T cell activation and serve a signaling function but can also be damaging. In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria.
authors.affiliation: Genetics and Genomic Sciences Department, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors.forename: Judith
authors.initials: J
authors.lastname: Agudo
authors.affiliation: Genetics and Genomic Sciences Department, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: brian.brown@mssm.edu.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Brown
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D008089:Listeria monocytogenes / Q000276:immunology*; D008088:Listeriosis / Q000276:immunology*; D008099:Liver / Q000473:pathology*; D035683:MicroRNAs / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*
chemical_list: D035683:MicroRNAs