title: Patient centric formulations for paediatrics and geriatrics: Similarities and differences.
abstract: Paediatrics and geriatrics both represent highly heterogenous populations and require special consideration when developing appropriate dosage forms. This paper discusses similarities, differences and considerations with respect to the development of appropriate medicine formulations for paediatrics and geriatrics. Arguably the most significant compliance challenge in older people is polypharmacy, whereas for children the largest barrier is taste. Pharmaceutical technology has progressed rapidly and technologies including FDCs, multi-particulates and orodispersible dosage forms provide unprecedented opportunities to develop novel and appropriate formulations for both old and new drugs. However, it is important for the formulation scientists to work closely with patients, carers and clinicians to develop such formulations for both the paediatric and geriatric population.
authors.affiliation: UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom. Electronic address: s.hanning@ucl.ac.uk.
authors.forename: Sara M
authors.initials: SM
authors.lastname: Hanning
authors.affiliation: UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
authors.forename: Felipe L
authors.initials: FL
authors.lastname: Lopez
authors.affiliation: UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
authors.forename: Ian C K
authors.initials: IC
authors.lastname: Wong
authors.affiliation: GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AW, United Kingdom.
authors.forename: Terry B
authors.initials: TB
authors.lastname: Ernest
authors.affiliation: UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
authors.forename: Catherine
authors.initials: C
authors.lastname: Tuleu
authors.affiliation: UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
authors.forename: Mine
authors.initials: M
authors.lastname: Orlu Gul
mesh_terms: D000368:Aged; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002648:Child; D004304:Dosage Forms; D016503:Drug Delivery Systems / Q000379:methods; D005853:Geriatrics / Q000379:methods*; D006801:Humans; D018802:Patient-Centered Care / Q000379:methods*; D010372:Pediatrics / Q000379:methods*
chemical_list: D004304:Dosage Forms
keywords: Dosage form; Excipients; Geriatric; Medicine; Paediatric; Patient-centric