title: HIV positivity and anal cancer outcomes: A single-center experience.
abstract: BACKGROUND
  Anal cancer remains common among human immunodeficiency virus (HIV) patients. Chemoradiation has had mixed results. We evaluated outcome differences by HIV status.
  
  
  METHODS
  We retrospectively analyzed 14 HIV+ and 72 HIV- anal cancer patients (2000 to 2013). Outcomes included chemoradiation tolerance, recurrence, and survival.
  
  
  RESULTS
  HIV+ patients were more often male (100% vs 38%, P < .001) but diagnosed at similar stages (P = .49). They were less likely to receive traditional chemotherapy (36% vs 86%, P < .001). Recurrence (P = .55) and survival time (P = .48) were similar across groups. HIV+ patients had similar colostomy-free survival (P = .053). Receipt of 5-fluorouracil/mitomycin C (MMC) chemotherapy predicted recurrence-free and overall survival (Hazard ratios .278, .32). HIV status did not worsen recurrence (P = .71) or survival (P = .57).
  
  
  CONCLUSIONS
  HIV+ patients received more non-MMC-based chemoradiation but had equivalent colostomy-free, recurrence, and overall survival. Use of 5-fluorouracil/MMC chemotherapy increased after 2008.
authors.affiliation: Division of Gastrointestinal and General Surgery, Department of Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mailcode L223A, Portland, OR 97239, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Wieghard
authors.affiliation: Division of Gastrointestinal and General Surgery, Department of Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mailcode L223A, Portland, OR 97239, USA.
authors.forename: Kyle D
authors.initials: KD
authors.lastname: Hart
authors.affiliation: Division of Gastrointestinal and General Surgery, Department of Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mailcode L223A, Portland, OR 97239, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Kelley
authors.affiliation: Division of Gastrointestinal and General Surgery, Department of Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mailcode L223A, Portland, OR 97239, USA.
authors.forename: Kim C
authors.initials: KC
authors.lastname: Lu
authors.affiliation: Division of Gastrointestinal and General Surgery, Department of Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mailcode L223A, Portland, OR 97239, USA.
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Herzig
authors.affiliation: Department of Radiation Oncology, Oregon Health & Science University, Portland, OR, USA.
authors.forename: Timur
authors.initials: T
authors.lastname: Mitin
authors.affiliation: Department of Radiation Oncology, Oregon Health & Science University, Portland, OR, USA.
authors.forename: Charles R
authors.initials: CR
authors.lastname: Thomas
authors.affiliation: Division of Gastrointestinal and General Surgery, Department of Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mailcode L223A, Portland, OR 97239, USA. Electronic address: tsikitis@ohsu.edu.
authors.forename: Vassiliki Liana
authors.initials: VL
authors.lastname: Tsikitis
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D001003:Anal Canal / Q000601:surgery*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D001005:Anus Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D059248:Chemoradiotherapy / Q000379:methods*; D015331:Cohort Studies; D003131:Combined Modality Therapy; D015897:Comorbidity; D018572:Disease-Free Survival; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: Anal squamous cell carcinoma; HIV; Outcomes