title: Applied Developmental Biology: Making Human Pancreatic Beta Cells for Diabetics.
abstract: Understanding the genes and signaling pathways that determine the differentiation and fate of a cell is a central goal of developmental biology. Using that information to gain mastery over the fates of cells presents new approaches to cell transplantation and drug discovery for human diseases including diabetes.
authors.affiliation: Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA. Electronic address: dmelton@harvard.edu.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Melton
mesh_terms: D000818:Animals; D015509:Developmental Biology; D003920:Diabetes Mellitus / Q000628:therapy*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology* / Q000637:transplantation*; D015398:Signal Transduction
keywords: Beta cell; Diabetes; Differentiation; Pancreas; Stem cell