title: Proteomic strategies in the search for novel pancreatic cancer biomarkers and drug targets: recent advances and clinical impact.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers; despite a low incidence rate it is the fourth leading cause of cancer-related death in the world. Improvement of the diagnosis, prognosis and treatment remains the main focus of pancreatic cancer research. Rapid developments in proteomic technologies has improved our understanding of the pancreatic cancer proteome. Here, the authors summarise the recent proteomic strategies undertaken in the search for: novel biomarkers for early diagnosis, pancreatic cancer-specific proteins which may be used for novel targeted therapies and proteins which may be useful for monitoring disease progression post-therapy. Recent advances and findings discussed here provide great promise of having a significant clinical impact and improving the outcome of patients with this malignancy.
authors.affiliation: a Department of Proteomics, National Institute for Cellular Biotechnology , Dublin City University , Glasnevin , Dublin 9 , Ireland.
authors.forename: Orla
authors.initials: O
authors.lastname: Coleman
authors.affiliation: a Department of Proteomics, National Institute for Cellular Biotechnology , Dublin City University , Glasnevin , Dublin 9 , Ireland.
authors.forename: Michael
authors.initials: M
authors.lastname: Henry
authors.affiliation: b St. Lukes Hospital , Rathgar , Dublin 6 , Ireland.
authors.forename: Gerard
authors.initials: G
authors.lastname: McVey
authors.affiliation: a Department of Proteomics, National Institute for Cellular Biotechnology , Dublin City University , Glasnevin , Dublin 9 , Ireland.
authors.forename: Martin
authors.initials: M
authors.lastname: Clynes
authors.affiliation: a Department of Proteomics, National Institute for Cellular Biotechnology , Dublin City University , Glasnevin , Dublin 9 , Ireland.|b St. Lukes Hospital , Rathgar , Dublin 6 , Ireland.
authors.forename: Michael
authors.initials: M
authors.lastname: Moriarty
authors.affiliation: a Department of Proteomics, National Institute for Cellular Biotechnology , Dublin City University , Glasnevin , Dublin 9 , Ireland.
authors.forename: Paula
authors.initials: P
authors.lastname: Meleady
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D044584:Carcinoma, Ductal / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D040901:Proteomics / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor
keywords: Pancreatic cancer; biomarkers; diagnosis; drug targets; proteomics; treatment