title: Partial distal 10q trisomy due to de novo amplification: A new case without furrows or ridges in fingers and palms.
abstract: BACKGROUND
  Here we describe a new case of partial distal 10q trisomy in a 6-year-old Iranian girl from healthy parents with mental, growth, and psychomotor retardations.
  
  
  METHODS
  Additional clinical features include dysmorphic craniofacial features, microcephaly, bilateral hydronephrosis without heart problems, small and rotated low-set ears, bow-shaped mouth, abnormal teeth, short neck, and as a first case reported, fingers with camptodactly (i.e., without any furrows or ridges in the palms and fingers).
  
  
  RESULTS
  Cytogenetic analysis (GTG-banding) revealed an unbalanced female karyotype with additional bands at the end of the long arm of chromosome 10, karyotype: 46,XX,dup(10)(q25q26).
  
  
  CONCLUSIONS
  According to the banding pattern it is most likely that a duplication of the distal part of the long arm of chromosome 10 occurred.
authors.affiliation: Bahrami hospital, Medical Sciences/University of Tehran, Iran, PO Box 14155-1595.
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Rahbarimanesh
authors.affiliation: Bahrami hospital, Medical Sciences/University of Tehran, Iran, PO Box 14155-1595.; Department of Medical Genetics, Medical Sciences/University of Tehran, Iran, PO Box 14155-1595; Medizinisch Genetisches Zentrum (MGZ), Munich, Germany, P.O. Box 201412.
authors.forename: Pupak
authors.initials: P
authors.lastname: Derakhshandeh-Peykar
authors.affiliation: Bahrami hospital, Medical Sciences/University of Tehran, Iran, PO Box 14155-1595.
authors.forename: Amirhassan
authors.initials: A
authors.lastname: Barkhordari
authors.affiliation: Department of Medical Genetics, Medical Sciences/University of Tehran, Iran, PO Box 14155-1595.
authors.forename: Reza
authors.initials: R
authors.lastname: Ebrahimzadeh-Vesal
authors.affiliation: Bahrami hospital, Medical Sciences/University of Tehran, Iran, PO Box 14155-1595.
authors.forename: Soja
authors.initials: S
authors.lastname: Shamizadeh Kalkhoran
keywords: 10q; Distal; Trisomy; de novo