title: Management of Loeffler's Endocarditis With Bivalvular Involvement and a FIP1L1/PDGFRA-Negative Mutation.
abstract: Hypereosinophilic syndromes (HESs) are a group of disorders characterized by end-organ damage caused by eosinophilic infiltration. We present a patient with idiopathic HES with severe tricuspid and mitral regurgitation secondary to Loeffler's endocarditis. In addition to prednisone, imatinib therapy initially helped control the eosinophil count. However, successful long-term remission was achieved with hydroxyurea therapy.
authors.affiliation: Department of Cardiology, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec City, Québec, Canada. Electronic address: mario.senechal@criucpq.ulaval.ca.
authors.forename: Mario
authors.initials: M
authors.lastname: Sénéchal
authors.affiliation: Department of Cardiology, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec City, Québec, Canada.
authors.forename: Pierre-Louis
authors.initials: PL
authors.lastname: Bernard
authors.affiliation: Department of Cardiology, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec City, Québec, Canada.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Cloutier
authors.affiliation: Department of Cardiology, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec City, Québec, Canada.
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Leblanc
authors.affiliation: Department of Cardiology, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec City, Québec, Canada.
authors.forename: Éric
authors.initials: É
authors.lastname: Larose
authors.affiliation: Department of Cardiology, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec City, Québec, Canada.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Cinq-Mars
authors.affiliation: Department of Cardiology, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec City, Québec, Canada.
authors.forename: Michelle
authors.initials: M
authors.lastname: Dubois
mesh_terms: D000328:Adult; D001705:Bioprosthesis; D004452:Echocardiography / Q000379:methods; D005355:Fibrosis; D005820:Genetic Testing / Q000379:methods; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation / Q000379:methods; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D000068877:Imatinib Mesylate / Q000008:administration & dosage*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods; D008297:Male; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000601:surgery; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D010210:Papillary Muscles / Q000473:pathology*; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome; D014261:Tricuspid Valve / Q000000981:diagnostic imaging / Q000601:surgery
chemical_list: D047428:Protein Kinase Inhibitors; D000068877:Imatinib Mesylate