title: Coupled plasma filtration adsorption improves hemodynamics in septic shock.
abstract: Septic shock involves a dysregulation of the immune response to an infection. This may lead to hemodynamic dysfunction and multiple-organ failure. The main aim of this study was to evaluate the effect of coupled plasma filtration adsorption (CPFA) on the hemodynamic profile in patients with septic shock.
  
  
  
  We retrospectively analyzed data from 21 adult patients admitted to the intensive care unit with a diagnosis of septic shock, comparing data between pre-CPFA and post-CPFA treatment. They received a maximum of 5 cycles of treatment.
  
  
  
  Coupled plasma filtration adsorption treatment was associated with a significant increase of mean arterial pressure (P < .001), reduction of the vasoactive/inotropic requirement (P = .007), and renal improvement. In patients with leukocytosis or leucopenia, the leukocyte count was restored to a reference range of values.
  
  
  
  Treatment with CPFA improves hemodynamic parameters in septic shock patients, ameliorating organ failure.
authors.affiliation: University of Pisa, 56126 Pisa, Italy. Electronic address: matteoals@gmail.com.
authors.forename: Matteo
authors.initials: M
authors.lastname: Franchi
authors.affiliation: University of Pisa, 56126 Pisa, Italy. Electronic address: marilugiacalone@gmail.com.
authors.forename: Marilù
authors.initials: M
authors.lastname: Giacalone
authors.affiliation: University of Pisa, 56126 Pisa, Italy. Electronic address: ippolito82@hotmail.it.
authors.forename: Ippolito
authors.initials: I
authors.lastname: Traupe
authors.affiliation: Department of Anesthesia and Intensive Care, Azienda Ospedaliera Universitaria Pisana, 56124 Pisa, Italy. Electronic address: r.rago@ao-pisa.toscana.it.
authors.forename: Rocco
authors.initials: R
authors.lastname: Rago
authors.affiliation: University of Pisa, 56126 Pisa, Italy. Electronic address: giacomo.baldi@gmail.com.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Baldi
authors.affiliation: University of Pisa, 56126 Pisa, Italy; Department of Anesthesia and Intensive Care, Azienda Ospedaliera Universitaria Pisana, 56124 Pisa, Italy. Electronic address: fgiunta@med.unipi.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Giunta
authors.affiliation: University of Pisa, 56126 Pisa, Italy; Department of Anesthesia and Intensive Care, Azienda Ospedaliera Universitaria Pisana, 56124 Pisa, Italy. Electronic address: francescoforfori@gmail.com.
authors.forename: Francesco
authors.initials: F
authors.lastname: Forfori
mesh_terms: D000327:Adsorption; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003422:Critical Care; D005260:Female; D005440:Fluid Therapy; D006439:Hemodynamics; D006440:Hemofiltration; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure; D010949:Plasma / Q000502:physiology*; D012189:Retrospective Studies; D012772:Shock, Septic / Q000097:blood / Q000401:mortality / Q000628:therapy*
keywords: CPFA; Cytokines; Hemodynamics; Multiple organ failure; Septic shock