title: Combinatorial Lanthipeptides from a Ruminant Bacterium.
abstract: New tools and molecules are spurring a renewed interest in natural products. In this issue of Cell Chemical Biology, Zhao and van der Donk (2016) report a single lantibiotic cluster encoding different α- and β-peptides, each with its dedicated processing enzyme. A number of clever experiments led to in vitro production of these molecules.
authors.affiliation: Naicons Srl, 20139 Milan, Italy. Electronic address: stefano.donadio@ktedogen.com.
authors.forename: Stefano
authors.initials: S
authors.lastname: Donadio
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D001419:Bacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics; D001430:Bacteriocins; D001688:Biological Products; D020650:Combinatorial Chemistry Techniques; D019295:Computational Biology; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D005810:Multigene Family; D010455:Peptides / Q000737:chemistry*; D011499:Protein Processing, Post-Translational; D012418:Ruminants / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001430:Bacteriocins; D001688:Biological Products; D010455:Peptides