title: Rare case of radiation-induced trigeminal schwannoma occurring in a long-term glioblastoma multiforme survivor.
abstract: Glioblastoma multiforme (GBM) is a high-grade primary brain tumour with a notably poor prognosis. Research demonstrates a median survival of just over 1 year following aggressive treatment. Long-term survival is notably rare. Cranial radiotherapy and postexcisional prophylactic treatment is associated with the development of second, histologically distinct tumours in rare cases. Radiation-induced intracranial schwannomas are uncommon, with only a small number of cranial nerve schwannoma cases reported in recent decades. To our knowledge, this is the first reported case of a radiation-induced benign trigeminal schwannoma occurring following long-term survival from glioblastoma. Here we present (1) a rare case of 14-year survival following treatment of a right parietal glioblastoma and the development of a radiation-induced benign trigeminal schwannoma in a 35-year-old man, and (2) a review of radiation-induced schwannoma cases reported in the existing literature.
authors.affiliation: School of Medicine, Keele University, Staffordshire, UK.
authors.forename: Mina
authors.initials: M
authors.lastname: Al Shalchi
authors.affiliation: School of Medicine, Keele University, Staffordshire, UK.
authors.forename: Shaila
authors.initials: S
authors.lastname: Hussain
authors.affiliation: Cancer Centre, University Hospital of North Midlands, Stoke-on-Trent, UK.
authors.forename: Selvaraj
authors.initials: S
authors.lastname: Giridharan
authors.affiliation: Department of Neurosurgery, University Hospital of North Midlands, Stoke-on-Trent, UK.
authors.forename: Erminia
authors.initials: E
authors.lastname: Albanese
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000209:etiology*; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis / Q000209:etiology*; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis*; D009442:Neurilemmoma / Q000175:diagnosis / Q000209:etiology*; D017741:Survivors; D020433:Trigeminal Nerve Diseases / Q000175:diagnosis / Q000209:etiology*