title: Chitosan wound dressing with hexagonal silver nanoparticles for hyperthermia and enhanced delivery of small molecules.
abstract: Chitosan films were synthesized with hexagonal silver nanoparticles (Ag NP). The unique shape and size of the Ag NP shift the optical absorption into the infrared. Stimulation of the nanoparticles with infrared light was used to generate heat and facilitate intracellular delivery of fluorescently-labeled dextran molecules. Chitosan films prepared with hexagonal or spherical Ag NP were characterized by optical and thermal analyses, and X-ray diffraction. There were found to be slight differences between how the chitosan molecular chains interface with the Ag NP depending upon shape of the nanoparticle. Viability of cells associated with dermal wound healing was evaluated on chitosan films prepared with hexagonal or spherical Ag NP, with both keratinocytes and fibroblasts having normal or moderately enhanced growth on films containing hexagonally-shaped nanoparticles.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Wake Forest University Health Sciences, Winston-Salem, NC, USA. Electronic address: nlevi@wakehealth.edu.
authors.forename: Nicole
authors.initials: N
authors.lastname: Levi-Polyachenko
authors.affiliation: Department of Plastic and Reconstructive Surgery, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
authors.forename: Reuben
authors.initials: R
authors.lastname: Jacob
authors.affiliation: Department of Chemistry, Wake Forest University, Winston-Salem, NC, USA.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Day
authors.affiliation: Department of Physics and Astronomy, College of Charleston, Charleston, SC, USA.
authors.forename: Narayanan
authors.initials: N
authors.lastname: Kuthirummal
mesh_terms: D000818:Animals; D001458:Bandages; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D003911:Dextrans / Q000378:metabolism; D016503:Drug Delivery Systems; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives / Q000378:metabolism; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced; D007259:Infrared Rays; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D061251:Primary Cell Culture; D012235:Rhodamines / Q000378:metabolism; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology; D013552:Swine; D014961:X-Ray Diffraction
chemical_list: D003911:Dextrans; D012235:Rhodamines; C015219:fluorescein isothiocyanate dextran; C051311:rhodamine dextran; D012834:Silver; D048271:Chitosan; D016650:Fluorescein-5-isothiocyanate
keywords: Chitosan; Hyperthermia; Nanoparticles; Wound dressing