title: FormylBODIPYs: Privileged Building Blocks for Multicomponent Reactions. The Case of the Passerini Reaction.
abstract: Eleven formyl-containing BODIPY dyes were prepared by means of either the Liebeskind-Srogl cross-coupling reaction or the Vilsmeier reaction. These dyes were used as components in the Passerini reaction to give highly substituted BODIPY dyes. A joined spectroscopic and theoretical characterization of the synthesized compounds was conducted to unravel the impact of the structural rigidity/flexibility on the photophysical signatures. These dyes were tested as fluorescent trackers for phagocytosis. Additionally, they proved to be useful to stain different blood cells with an intense and stable signal at a very low exposure time.
authors.forename: Diana E
authors.initials: DE
authors.lastname: Ramírez-Ornelas
authors.forename: Enrique
authors.initials: E
authors.lastname: Alvarado-Martínez
authors.affiliation: Departamento de Química Física, Universidad del País Vasco-EHU , Apartado 644, 48080 Bilbao, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Bañuelos
authors.affiliation: Departamento de Química Física, Universidad del País Vasco-EHU , Apartado 644, 48080 Bilbao, Spain.
authors.forename: Iñigo
authors.initials: I
authors.lastname: López Arbeloa
authors.affiliation: Departamento de Química Física, Universidad del País Vasco-EHU , Apartado 644, 48080 Bilbao, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Arbeloa
authors.forename: Héctor M
authors.initials: HM
authors.lastname: Mora-Montes
authors.forename: Luis A
authors.initials: LA
authors.lastname: Pérez-García
authors.forename: Eduardo
authors.initials: E
authors.lastname: Peña-Cabrera
mesh_terms: D001896:Boron Compounds; D057899:Cytophagocytosis / Q000187:drug effects; D005456:Fluorescent Dyes / Q000737:chemistry*; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes