title: Manifestations of Complement-Mediated and Immune Complex-Mediated Membranoproliferative Glomerulonephritis: A Comparative Consecutive Series.
abstract: Membranoproliferative glomerulonephritis (MPGN) recently was reclassified to reflect the underlying cause as a complement-mediated and immune complex-mediated disease. This classification is based on renal biopsy immunofluorescence examination, making the former electron-microscopy classification obsolete. In this report, we describe related eye findings in patients with MPGN based on the new classification.
  
  
  
  Retrospective case series.
  
  
  
  All Mayo Clinic Rochester patients with pathology-confirmed complement- and immune complex-mediated MPGN who had available ophthalmology records from 1997 through 2014 were included in this study.
  
  
  
  The medical and pathologic records of patients with MPGN and eye examination results were reviewed from years 1997 through 2014.
  
  
  
  The number of patients and the number of eyes with MPGN-related pathologic features were examined. Visual acuity also was considered.
  
  
  
  There were 23 patients with complement-mediated MPGN and available eye examination results. Of these, 9 patients (39%) and 17 eyes (37%) had retinal pathologic features that likely were related to the same underlying pathophysiologic process as their renal disease. Five patients (22%) and 6 eyes (13%) had significant vision loss. There were 23 patients with immune complex-mediated MPGN and available eye examination results. Only 2 (9%) of these patients (4 eyes) had retinal pathologic features that potentially could be related to the same underlying pathophysiologic process as their renal disease, and neither had vision loss.
  
  
  
  Retinal abnormalities are more prominent among patients with complement-mediated MPGN when compared with patients with immune complex-mediated MPGN. It is critical for ophthalmologists to recognize the updated MPGN classification system, and all patients with complement-mediated MPGN require screening eye examinations.
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Dalvin
authors.affiliation: Department of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
authors.forename: Fernando C
authors.initials: FC
authors.lastname: Fervenza
authors.affiliation: Department of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Sethi
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: pulido.jose@mayo.edu.
authors.forename: Jose S
authors.initials: JS
authors.lastname: Pulido
mesh_terms: D000328:Adult; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000145:classification / Q000150:complications* / Q000473:pathology; D006801:Humans; D007105:Immune Complex Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000473:pathology* / Q000503:physiopathology; D015593:Retinal Drusen / Q000473:pathology; D055213:Retinal Pigment Epithelium / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult