title: Radiofrequency ablation and surgical resection of liver metastases from uveal melanoma.
abstract: BACKGROUND
  The resection of liver metastasis from uveal melanoma (LMUM) remains controversial. In this study, we evaluated treatment with radiofrequency ablation (RFA) for liver metastases alone or in combination with surgical liver resection.
  
  
  METHODS
  A total of 72 patients with LMUM were evaluated in this study. Of these, 57 patients underwent surgical resection (S) while 15 patients had RFA ± S. Clinicopathologic factors were evaluated in terms of recurrence and survival using Chi-square and log-rank tests, respectively.
  
  
  RESULTS
  We studied 22 metastases treated by RFA. There were no statistically significant differences between the groups in terms of median age of onset, synchronous nature of the metastases, time from primary tumour treatment to liver metastasis, diameter of the largest metastasis, presence of liver miliary disease, and the type of liver resection. There was a statistically lower number of liver metastases and more bilobar metastases in the RFA group than in the S group. The median overall survival after liver surgery was 27 months in group S and 28 months in the RFA group ± S. The median disease-free survival was 10 months in group S and 7 months in the RFA group ± S. There were no statistically significant differences in the median overall survival and disease-free survival between groups.
  
  
  CONCLUSIONS
  The results of this retrospective analysis show that RFA can be used to treat liver metastases to spare the hepatic parenchyma. RFA ± liver surgery and liver surgery alone demonstrate similar survival times.
authors.affiliation: Department of Surgical Oncology, Institut Curie, 26 rue d'Ulm-75248, Paris Cedex 05, France. Electronic address: pascale.mariani@curie.net.
authors.forename: P
authors.initials: P
authors.lastname: Mariani
authors.affiliation: Department of Surgical Oncology, Institut Curie, 26 rue d'Ulm-75248, Paris Cedex 05, France.
authors.forename: M M
authors.initials: MM
authors.lastname: Almubarak
authors.affiliation: Department of Radiology, Institut Curie, 26 rue d'Ulm-75248, Paris Cedex 05, France.
authors.forename: M
authors.initials: M
authors.lastname: Kollen
authors.affiliation: Department of Radiology, Institut Curie, 26 rue d'Ulm-75248, Paris Cedex 05, France.
authors.forename: M
authors.initials: M
authors.lastname: Wagner
authors.affiliation: Department of Biostatistics, Institut Curie, 26 rue d'Ulm-75248, Paris Cedex 05, France.
authors.forename: C
authors.initials: C
authors.lastname: Plancher
authors.affiliation: Department of Surgical Oncology, Institut Curie, 26 rue d'Ulm-75248, Paris Cedex 05, France.
authors.forename: R
authors.initials: R
authors.lastname: Audollent
authors.affiliation: Department of Medical Oncology, Institut Curie, 26 rue d'Ulm-75248, Paris Cedex 05, France.
authors.forename: S
authors.initials: S
authors.lastname: Piperno-Neumann
authors.affiliation: Department of Surgical Oncology, Institut Curie, 26 rue d'Ulm-75248, Paris Cedex 05, France.
authors.forename: N
authors.initials: N
authors.lastname: Cassoux
authors.affiliation: Department of Radiology, Institut Curie, 26 rue d'Ulm-75248, Paris Cedex 05, France.
authors.forename: V
authors.initials: V
authors.lastname: Servois
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000556:secondary / Q000601:surgery*; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000473:pathology*
keywords: Liver metastasis; Liver surgery; Radiofrequency ablation; Uveal melanoma