title: Polymorphism rs144848 in BRCA2 may reduce lung cancer risk in women: a case-control study in southeast China.
abstract: OBJECTIVE
  Whereas lung cancer incidence among men has declined in recent years, the incidence rate among women has increased rapidly. Sex could affect DNA repair capacity. Although BRCA2 is important in DNA repair, few data are available on the association between BRCA2 polymorphisms and lung cancer in women. Therefore, we investigated this in a case-control study among Chinese women.
  
  
  METHODS
  We enrolled 226 women with lung cancer and 269 age-matched healthy controls in our study. Polymorphisms studied were genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
  
  
  RESULTS
  Unconditional logistic regression showed no association between rs1799943 or rs1799944 and cancer risk. However, the AC and CC genotypes of rs144848 were significantly associated with reduced risk after adjustment for age and education, with adjusted odds ratios (ORs) of 0.66 (95% confidence interval [CI] 0.45-0.97) and 0.37 (95% CI 0.16-0.78), respectively. The adjusted OR of carriers with the C allele was 0.62 (95% CI 0.44-0.81) compared with the A allele.
  
  
  CONCLUSIONS
  The rs144848 mutation may have a protective effect against lung cancer among women.
authors.affiliation: School of Public Health, Fujian Medical University, Fuzhou, Fujian Province - People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Lin
authors.affiliation: School of Public Health, Fujian Medical University, Fuzhou, Fujian Province - People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.affiliation: School of Public Health, Fujian Medical University, Fuzhou, Fujian Province - People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Public Health, Fujian Medical University, Fuzhou, Fujian Province - People's Republic of China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Yu
authors.affiliation: School of Public Health, Fujian Medical University, Fuzhou, Fujian Province - People's Republic of China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Public Health, Fujian Medical University, Fuzhou, Fujian Province - People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data*; D024682:BRCA2 Protein / Q000235:genetics*; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004260:DNA Repair / Q000235:genetics; D004522:Educational Status; D005260:Female; D024522:Genes, BRCA2; D005838:Genotype; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control*; D017533:Marital Status; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment
chemical_list: D024682:BRCA2 Protein; C551750:BRCA2 protein, human