title: Reverse asymmetry and changes in brain structural volume of the basal ganglia in ADHD, developmental changes and the impact of stimulant medications.
abstract: We discussed the cross section studies and the meta-analysis of published data in children and adolescents with ADHD (both drug naive and receiving stimulant medications), in comparison with healthy children and adolescents of the same age. In children and adolescents with ADHD the deceleration of the maturation dynamics of discrete CNS structures is found, volume reduction and decreased grey matter in prefrontal and occipital regions, which is accompanied by reverse asymmetry of the basal ganglia volume (putamen, nucleus caudate). The above mentioned developmental characteristics are valid only for the ADHD children, who have not been treated by stimulant medications. The stimulant treatment eliminates the mentioned changes into various extend. These developmental changes of CNS structures volume are missing in girls.
authors.forename: Ivo
authors.initials: I
authors.lastname: Paclt
authors.forename: Nikol
authors.initials: N
authors.lastname: Pribilová
authors.forename: Patricie
authors.initials: P
authors.lastname: Kollárová
authors.forename: Milada
authors.initials: M
authors.lastname: Kohoutová
authors.forename: Monika
authors.initials: M
authors.lastname: Dezortová
authors.forename: Milan
authors.initials: M
authors.lastname: Hájek
authors.forename: Ladislav
authors.initials: L
authors.lastname: Csemy
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000473:pathology*; D001479:Basal Ganglia / Q000002:abnormalities* / Q000187:drug effects / Q000473:pathology; D001921:Brain / Q000002:abnormalities* / Q000187:drug effects / Q000473:pathology; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size / Q000187:drug effects
chemical_list: D000697:Central Nervous System Stimulants