title: [Associations of lipoproteins with bone mass in postmenopausal women].
abstract: OBJECTIVE
  To study an association between blood lipid composition and bone mass in Russian postmenopausal women.
  
  
  METHODS
  The cross-sectional study included 373 postmenopausal women aged 45-80 years who were examined to diagnose osteoporosis in outpatient settings. Height, body weight, and waist and hip circumferences (WC and HC) were measured before densitometry. Quetelet's index was calculated as a ratio of weight (kg) to height (m2). The concentration of lipids and apolipoproteins (apo) AІ and B were measured by enzyme immunoassay. Bone mineral density (BMD) in the spine and proximal femur (PF) was estimated by dual-energy X-ray absorptiometry.
  
  
  RESULTS
  According to bone mass, the patients were divided into three groups: 1) osteoporosis (OP); 2) osteopenia; 3) normal BMD. The levels of total cholesterol and high-density lipoprotein (HDL) cholesterol were significantly higher in the postmenopausal women with OP than in those with normal bone mass. There was a negative correlation of cholesterol and HDL cholesterol levels with lumbar spine BMD and that of HDL levels with BMD in the femoral neck (FN) and entire PF. The level of lipoprotein (a) (LPa) was significantly lower in the group of patients with OP and positively correlated with BMD in FN and entire PF. After adjustment for age, the duration of menopause, Quetelet's index, and WC/HC association remained only between LPa and FN BMD.
  
  
  CONCLUSIONS
  Multivariate regression analysis failed to confirm a trend towards decreased BMD and increased HDL cholesterol. This suggests that the association of HDL cholesterol with bone mass is apparently mediated by other factors and, above all, with age, postmenopausal hormonal status and body weight.
authors.affiliation: National Research Center for Preventive Medicine, Ministry of Health of Russia, Moscow, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Skripnikova
authors.affiliation: National Research Center for Preventive Medicine, Ministry of Health of Russia, Moscow, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Abirova
authors.affiliation: National Research Center for Preventive Medicine, Ministry of Health of Russia, Moscow, Russia.
authors.forename: P A
authors.initials: PA
authors.lastname: Alyasova
authors.affiliation: National Research Center for Preventive Medicine, Ministry of Health of Russia, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Alikhanova
authors.affiliation: National Research Center for Preventive Medicine, Ministry of Health of Russia, Moscow, Russia.
authors.forename: M B
authors.initials: MB
authors.lastname: Khudyakov
authors.affiliation: National Research Center for Preventive Medicine, Ministry of Health of Russia, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Vygodin
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000368:Aged; D015992:Body Mass Index; D015519:Bone Density; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D017698:Postmenopause / Q000378:metabolism*; D012426:Russia / Q000453:epidemiology; D013223:Statistics as Topic
chemical_list: D008074:Lipoproteins