title: Genetic polymorphisms of interleukin-22 in patients with ulcerative colitis.
abstract: BACKGROUND
  Ulcerative colitis (UC) is a multifactorial and polygenic disease. Interleukin-22 (IL-22) is an immunomodulatory cytokine that belongs to the IL-10 family. Currently, some IL-22 polymorphisms have been associated with inflammatory processes such as rheumatoid arthritis and psoriasis vulgaris, but there are no studies on UC.
  
  
  OBJECTIVE
  The aim of this work was to study the frequency of polymorphisms of IL-22 in Mexican patients with UC.
  
  
  METHODS
  We studied a total of 199 Mexican patients with confirmed UC and 697 healthy controls. All individuals were born in Mexico, at least three family generations earlier. A blood sample was obtained from the UC patients and healthy controls in order to perform DNA extraction and then to determine the frequency of IL-22 polymorphisms (rs2227485, rs2272478, rs2227491).
  
  
  RESULTS
  No statistical significance was found in the gene and genotype frequencies of three SNPs of IL-22 (rs2227485, rs2272478, rs2227491) between the UC patients and healthy controls. No association was found between those IL-22 SNPs and clinical features of UC.
  
  
  CONCLUSIONS
  There was no association between IL-22 SNPs (rs2227485, rs2272478, rs2227491) and the development of UC in a Mexican population.
authors.affiliation: Clínica de Enfermedad Inflamatoria Intestinal, Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México. Electronic address: kazuofurusho@hotmail.com.
authors.forename: J K
authors.initials: JK
authors.lastname: Yamamoto-Furusho
authors.affiliation: Clínica de Enfermedad Inflamatoria Intestinal, Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.
authors.forename: G E
authors.initials: GE
authors.lastname: Sánchez-Morales
authors.affiliation: Clínica de Enfermedad Inflamatoria Intestinal, Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.
authors.forename: D
authors.initials: D
authors.lastname: García-Rangel
authors.affiliation: Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: G
authors.initials: G
authors.lastname: Vargas-Alarcón
mesh_terms: D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D000097043:Interleukin-22
chemical_list: D004247:DNA; D007378:Interleukins; D000097043:Interleukin-22
keywords: Colitis ulcerosa; Genetic susceptibility; IL-22 polymorphisms; Inflamación; Inflammation; Mexican; Población mexicana; Polimorfismo IL-22; Susceptibilidad genética; Ulcerative colitis