title: A Patient with Abnormal Kidney Function and a Monoclonal Light Chain in the Urine.
abstract: Monoclonal gammopathy is increasingly recognized as a cause of kidney injury. These renal conditions behave differently than ones without monoclonal gammopathy and require specific treatment. To avoid misdiagnosis, testing for paraprotein should be performed in addition to vasculitis and autoimmune diseases serologies in adults with unexplained AKI or proteinuria. Because the prevalence of monoclonal gammopathy is much more common than glomerular diseases, the nephrotoxicity of the monoclonal protein must be confirmed before cytotoxic therapy is initiated. This can only be done by a kidney biopsy. After a monoclonal gammopathy of renal significant is verified, the evaluation should then focus on the identification of the pathologic clone, because therapy is clone specific. We present this patient to illustrate the clinical presentation of a patient with renal dysfunction and a monoclonal gammopathy. This patient is also used to discuss the diagnostic process in detail when monoclonal gammopathy-associated renal disease is suspected.
authors.affiliation: Divisions of Nephrology and Hypertension and.|Hematology and.
authors.forename: Nelson
authors.initials: N
authors.lastname: Leung
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Samih H
authors.initials: SH
authors.lastname: Nasr
mesh_terms: D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000652:urine*; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications* / Q000188:drug therapy / Q000652:urine
chemical_list: D007147:Immunoglobulin Light Chains
keywords: Acute Kidney Injury; Adult; Humans; MGRS; Paraproteins; glomerular disease; kidney biopsy; multiple myeloma; proteinuria; renal failure