title: The toxic effects on the stress and immune responses in juvenile rockfish, Sebastes schlegelii exposed to hexavalent chromium.
abstract: Juvenile Sebastes schlegelii (mean length 13.7±1.7cm, and mean weight 55.6±4.8g) were exposed for 4 weeks with the different levels of dietary chromium (Cr(6+)) concentration (0, 30, 60, 120 and 200mg/L). The plasma cortisol and heat shock protein 70 was evaluated as stress indicators. Plasma cortisol was significantly increased in response to the dietary chromium exposure over 120mg/kg at 2 and 4 weeks. Heat shock protein 70 was also notably increased over 120mg/kg at 2 weeks and over 60mg/kg at 4 weeks. In the immune response, immunoglobulin M was considerably increased in the concentration of 240mg/kg at 2 weeks and over 120mg/kg at 4 weeks. Lysozyme activity was considerably induced by the dietary hexavalent chromium exposure. A significant increase in plasma lysozyme activity was observed at 240mg/kg after 2 weeks and over 60mg/kg after 4 weeks, kidney lysozyme was also increased over 120mg/kg at 2 and 4 weeks. The results demonstrate that dietary Cr exposure can induce a significant stress and immune stimulation.
authors.affiliation: Department of Aquatic Life Medicine, Pukyong National University, Busan 608-737, Republic of Korea.
authors.forename: Jun-Hwan
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Aquatic Life Medicine, Pukyong National University, Busan 608-737, Republic of Korea. Electronic address: jckang@pknu.ac.kr.
authors.forename: Ju-Chan
authors.initials: JC
authors.lastname: Kang
mesh_terms: D000818:Animals; D001492:Bass / Q000502:physiology*; D002857:Chromium / Q000633:toxicity*; D007107:Immune System / Q000187:drug effects*; D013312:Stress, Physiological; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; D002857:Chromium; C074702:chromium hexavalent ion
keywords: Chromium; Immune response; Metal induced stress; Rockfish