title: Systematic evaluation of cancer risk associated with rs2292832 in miR‑149 and rs895819 in miR‑27a: a comprehensive and updated meta‑analysis.
abstract: The aim of this study is to provide a precise quantification for the association between miR-149 T > C (rs2292832) and miR-27a A > G (rs895819) and the risk of cancer. We conducted a systematic literature review and evaluated the quality of included studies based on Newcastle-Ottawa Scale (NOS). Pooled odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were calculated to assess the strengths of the associations. We identified 40 studies for pooled analyses. Overall, the results demonstrated that the rs2292832 polymorphism was subtly decrease the risk of breast cancer (CT + CC vs TT: OR = 0.83, 95% CI: 0.70-0.98, P = 0.03; CC vs CT + TT: OR = 0.80, 95% CI: 0.68-0.93, P = 0.00), and the rs895819 polymorphism wasassociated with significantly increased cancer risk in the Asian population (AG + GG vs AA: OR = 1.24, 95% CI: 1.03-1.50, P = 0.02) and in colorectal cancer subgroup (GG vs AA: OR = 1.45, 95% CI: 1.10-1.92, P = 0.00; AG + GG vs AA: OR = 1.35, 95% CI: 1.15-1.58, P = 0.00; GG vs AG + AA: OR = 1.36, 95% CI: 1.04-1.77, P = 0.02). In addition, a subtly decreased risk was observed in the Caucasian population and in breast cancer subgroup. In conclusion, the rs2292832 polymorphism was significantly associated with increased breast cancer risk, and the rs895819 polymorphism contributes to the susceptibility of colorectal and breast cancer.
authors.affiliation: Department of Infection Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, P.R.China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Hospital Infection Management, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, Henan, P.R.China.
authors.forename: Fujiao
authors.initials: F
authors.lastname: Duan
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, P.R.China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Song
authors.affiliation: Department of Hospital Infection Management, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, Henan, P.R.China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, P.R.China.
authors.forename: Liping
authors.initials: L
authors.lastname: Dai
authors.affiliation: College of Professional Study, Northeastern University, Boston, 02215 Massachusetts, USA.
authors.forename: Shuli
authors.initials: S
authors.lastname: Cui
mesh_terms: D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C551557:MIRN149 microRNA, human; C531388:MIRN27 microRNA, human; D035683:MicroRNAs
keywords: cancer; miR-149; miR-27a; susceptibility; systematic evaluation