title: Direct reprogramming of somatic cells into neural stem cells or neurons for neurological disorders.
abstract: Direct reprogramming of somatic cells into neurons or neural stem cells is one of the most important frontier fields in current neuroscience research. Without undergoing the pluripotency stage, induced neurons or induced neural stem cells are a safer and timelier manner resource in comparison to those derived from induced pluripotent stem cells. In this prospective, we review the recent advances in generation of induced neurons and induced neural stem cells in vitro and in vivo and their potential treatments of neurological disorders.
authors.affiliation: Spinal Cord Research Center, Department of Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
authors.forename: Shaoping
authors.initials: S
authors.lastname: Hou
authors.affiliation: Veterans Administration Medical Center, San Diego, CA, USA; Department of Neurosciences, University of California at San Diego, La Jolla, CA, USA.
authors.forename: Paul
authors.identifier: 0000-0001-7785-9620
authors.initials: P
authors.lastname: Lu
keywords: induced neural stem cells; induced neurons; neural cells; neurological diseases; pluripotent stem cells