title: Raman spectroscopy for early real-time endoscopic optical diagnosis based on biochemical changes during the carcinogenesis of Barrett's esophagus.
abstract: Raman spectroscopy is a spectroscopic technique based on the inelastic scattering of monochromatic light that represents the molecular composition of the interrogated volume to provide a direct molecular fingerprint. Several investigations have revealed that confocal Raman spectroscopy can differentiate non-dysplastic Barrett's esophagus from esophageal high-grade dysplasia and adenocarcinoma with high sensitivity and specificity. An automated on-line Raman spectral diagnostic system has made it possible to use Raman spectroscopy to guide accurate target biopsy instead of multiple random forceps-biopsies, this novel system is expected to improve in vivo precancerous diagnosis and tissue characterization of Barrett's esophagus.
authors.affiliation: Hong Shi, Su-Yu Chen, Department of Gastrointestinal Endoscopy, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, Fujian Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Shi
authors.affiliation: Hong Shi, Su-Yu Chen, Department of Gastrointestinal Endoscopy, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, Fujian Province, China.
authors.forename: Su-Yu
authors.initials: SY
authors.lastname: Chen
authors.affiliation: Hong Shi, Su-Yu Chen, Department of Gastrointestinal Endoscopy, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, Fujian Province, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Lin
keywords: Barrett’s esophagus; Confocal; Diagnosis; High-grade dysplasia; Raman spectroscopy