title: Interleukin-33: increasing role in dermatological conditions.
abstract: Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan IL-1 family receptor. Interleukin-33/ST2 signaling has been studied in a wide range of inflammatory skin conditions for its crucial role in immune responses and tissue homeostasis. In this review, we report the current knowledge regarding the complex biology of interleukin-33 and its function in the skin and in clinical settings.
authors.affiliation: Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, 80131, Italy. annabalato@yahoo.it.
authors.forename: Anna
authors.initials: A
authors.lastname: Balato
authors.affiliation: Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, 80131, Italy.
authors.forename: Annunziata
authors.initials: A
authors.lastname: Raimondo
authors.affiliation: Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, 80131, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Balato
authors.affiliation: Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, 80131, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Ayala
authors.affiliation: Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, 80131, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Lembo
mesh_terms: D056704:Adaptive Immunity; D006801:Humans; D007113:Immunity, Innate; D000072179:Interleukin-1 Receptor-Like 1 Protein / Q000378:metabolism*; D000067596:Interleukin-33 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D012871:Skin Diseases / Q000276:immunology* / Q000378:metabolism
chemical_list: C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33
keywords: IL-33; Immunity; ST2; Skin diseases