title: Mechanisms of nonsteroidal anti-inflammatory drugs in cancer prevention.
abstract: Various clinical and epidemiologic studies show that nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin and cyclooxygenase inhibitors (COXIBs) help prevent cancer. Since eicosanoid metabolism is the main inhibitory targets of these drugs the resulting molecular and biological impact is generally accepted. As our knowledge base and technology progress we are learning that additional targets may be involved. This review attempts to summarize these new developments in the field.
authors.affiliation: Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: umara@mail.nih.gov.
authors.forename: Asad
authors.initials: A
authors.lastname: Umar
authors.affiliation: Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Vernon E
authors.initials: VE
authors.lastname: Steele
authors.affiliation: The University of Texas MD Anderson Cancer Center, Division of Cancer Prevention and Population Sciences, Houston, TX, USA.
authors.forename: David G
authors.initials: DG
authors.lastname: Menter
authors.affiliation: The University of Texas MD Anderson Cancer Center, Division of Cancer Prevention and Population Sciences, Houston, TX, USA.
authors.forename: Ernest T
authors.initials: ET
authors.lastname: Hawk
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism* / Q000494:pharmacology* / Q000627:therapeutic use; D001241:Aspirin / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects; D018890:Chemoprevention; D016861:Cyclooxygenase Inhibitors / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D015232:Dinoprostone / Q000378:metabolism*; D015777:Eicosanoids / Q000037:antagonists & inhibitors / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007249:Inflammation / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D015777:Eicosanoids; D005947:Glucose; D015232:Dinoprostone; D001241:Aspirin
keywords: Aspirin; Cancer prevention; Inflammation; Non-steroidal anti-inflammatory drugs (NSAID)