title: Description of an intensive nutrition therapy in hospitalized adolescents with anorexia nervosa.
abstract: OBJECTIVE
  To describe an intensive nutrition therapy for hospitalized adolescents and young adults with anorexia nervosa (AN) in terms of body weight, body composition, energy balance and food related anxiety.
  
  
  METHODS
  Twenty-six young females, 16-24years of age, with AN were invited to participate at admission to a specialized eating disorder unit in Göteborg, Sweden. Intensive nutrition therapy comprised 12weeks on a structured meal plan. Six meals were served daily, in combination with high-energy liquid nutritional supplements from start. Energy and nutrient intakes, energy expenditure, body composition and food related anxiety were measured during the study. A 3-month follow-up of body weight and food related anxiety was conducted.
  
  
  RESULTS
  Twenty-one patients participated. The total daily energy intake was, during the first week of treatment, (mean±SD) 3264±196kcal (74kcal/kg), and decreased gradually during treatment to 2622±331kcal (49kcal/kg). Total daily energy expenditure was initially 1568±149kcal and increased gradually to 2034±194kcal. Patients gained on average 9.8±2.1kg and body mass index increased from 15.5±0.9 to 19.0±0.9kg/m(2). Body fat increased from 13±6% to 26±6%. Fat free mass remained unchanged, but skeletal muscle mass increased from 16.7±2.0 to 17.6±2.4kg, p=0.009. Patients' food related anxiety decreased significantly during treatment and was still unchanged 3months later.
  
  
  CONCLUSIONS
  The presented intensive nutrition therapy with initially high energy and nutrient intakes produced substantial weight gain, increased fat and muscle mass and decreased food related anxiety in AN patients, without any clinical side effects.
authors.affiliation: Anorexia-Bulimia Unit, The Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Göteborg, Sweden. Electronic address: cecilia.pettersson@vgregion.se.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Pettersson
authors.affiliation: Department of Pediatrics, Institute of Clinical Sciences, The Queen Silvia Children's Hospital, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden.
authors.forename: Bojan
authors.initials: B
authors.lastname: Tubic
authors.affiliation: Department of Pediatrics, Institute of Clinical Sciences, The Queen Silvia Children's Hospital, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Svedlund
authors.affiliation: Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linköping University, Linkoping, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Magnusson
authors.affiliation: Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Ellegård
authors.affiliation: Department of Pediatrics, Institute of Clinical Sciences, The Queen Silvia Children's Hospital, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden.
authors.forename: Diana
authors.initials: D
authors.lastname: Swolin-Eide
authors.affiliation: Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden.
authors.forename: Heléne Bertéus
authors.initials: HB
authors.lastname: Forslund
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D000298:Adolescent, Hospitalized; D000856:Anorexia Nervosa / Q000523:psychology / Q000628:therapy*; D001007:Anxiety / Q000628:therapy; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D019587:Dietary Supplements; D002149:Energy Intake; D004734:Energy Metabolism; D005260:Female; D005502:Food; D006801:Humans; D062407:Meals; D044623:Nutrition Therapy; D013548:Sweden; D015430:Weight Gain; D055815:Young Adult
keywords: Anorexia nervosa; Body composition; Energy balance; Energy intake; Food related anxiety; Nutrition therapy