title: [A comparative analysis of the efficacy of neuromidin and galantamine in Alzheimer's disease].
abstract: OBJECTIVE
  To evaluate the cognitive changes in patients with mild to moderate Alzheimer's disease after the treatment with acetylcholinesterase inhibitors - neuromidin and galantamine.
  
  
  METHODS
  Fifty-eight patients with probable Alzheimer's disease, aged 60-84 years (mean 73.2±6.7), were enrolled in a 20-week double-blind parallel group study. All patients were randomized in 2 groups: group 1 (n=28) received neuromidin, group 2 (n=30) - galantamine. Treatment efficacy was evaluated with the ADAS-cog/11 scale.
  
  
  RESULTS
  Both drugs significantly improved or stabilized cognitive function in the patients. The most marked changes were obtained in the group of patients treated with neuromidin (р<0.05).
  
  
  CONCLUSIONS
  The results suggest that the effectiveness of anticholinesterase treatment of Alzheimer's disease could be determined not only by the central but also peripheral cholinergic action.
authors.affiliation: Kirov Military Medical Academy, St. Petersburg.
authors.forename: S A
authors.initials: SA
authors.lastname: Zhivolupov
authors.affiliation: Kirov Military Medical Academy, St. Petersburg.
authors.forename: N A
authors.initials: NA
authors.lastname: Rashidov
authors.affiliation: Kirov Military Medical Academy, St. Petersburg.
authors.forename: I N
authors.initials: IN
authors.lastname: Samartsev
authors.affiliation: Medical Center 'Admiralteyskie Verfi', St. Petersburg.
authors.forename: E V
authors.initials: EV
authors.lastname: Jakovlev