title: Targeting Retinoid Receptors to Treat Schizophrenia: Rationale and Progress to Date.
abstract: This review provides the rationale and reports on the progress to date regarding the targeting of retinoid receptors for the treatment of schizophrenia and schizoaffective disorder and the role of retinoic acid in functions of the normal brain, and in psychotic states. After a brief introduction, we describe the normal function of retinoic acid in the brain. We then examine the evidence regarding retinoid dysregulation in schizophrenia. Finally, findings from two add-on clinical trials with a retinoid (bexarotene) are discussed. The authors of this review suggest that targeting retinoid receptors may be a novel approach to treat schizophrenia and schizoaffective disorder. Further studies are warranted.
authors.affiliation: Faculty of Health Sciences, Be'er Sheva Mental Health Center, Ben-Gurion University of the Negev, Beersheba, Israel.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Lerner
authors.affiliation: Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK.
authors.forename: Peter J A
authors.initials: PJ
authors.lastname: McCaffery
authors.affiliation: Department of Psychiatry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. ritsnerm@gmail.com.|Sha'ar Menashe Mental Health Center, Mobile Post Hefer, 37806, Hadera, Israel. ritsnerm@gmail.com.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Ritsner
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D018168:Receptors, Retinoic Acid / Q000378:metabolism*; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism*; D014212:Tretinoin / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D018168:Receptors, Retinoic Acid; D014212:Tretinoin