title: Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane.
abstract: With the properties of efficacy, safety, tolerability, practicability and low cost, foods containing bioactive phytochemicals are gaining significant attention as elements of chemoprevention strategies against cancer. Sulforaphane [1-isothiocyanato-4-(methylsulfinyl)butane], a naturally occurring isothiocyanate produced by cruciferous vegetables such as broccoli, is found to be a highly promising chemoprevention agent against not only a variety of cancers such as breast, prostate, colon, skin, lung, stomach or bladder, but also cardiovascular disease, neurodegenerative diseases, and diabetes. For reasons of experimental exigency, preclinical studies have focused principally on sulforaphane itself, while clinical studies have relied on broccoli sprout preparations rich in either sulforaphane or its biogenic precursor, glucoraphanin. Substantive subsequent evaluation of sulforaphane pharmacokinetics and pharmacodynamics has been undertaken using either pure compound or food matrices. Sulforaphane affects multiple targets in cells. One key molecular mechanism of action for sulforaphane entails activation of the Nrf2-Keap1 signaling pathway although other actions contribute to the broad spectrum of efficacy in different animal models. This review summarizes the current status of pre-clinical chemoprevention studies with sulforaphane and highlights the progress and challenges for the application of foods rich in sulforaphane and/or glucoraphanin in the arena of clinical chemoprevention.
authors.affiliation: Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261.
authors.forename: Dushani L
authors.initials: DL
authors.lastname: Palliyaguru
authors.affiliation: Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261. Electronic address: tkensler@pitt.edu.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Kensler
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D001937:Brassica; D018890:Chemoprevention; D005961:Glucosinolates / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007096:Imidoesters / Q000378:metabolism / Q000494:pharmacology; D017879:Isothiocyanates / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D051267:NF-E2-Related Factor 2 / Q000037:antagonists & inhibitors*; D009369:Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000517:prevention & control*; D010091:Oximes; D015398:Signal Transduction / Q000187:drug effects; D013454:Sulfoxides; D014675:Vegetables
chemical_list: D016588:Anticarcinogenic Agents; D005961:Glucosinolates; D007096:Imidoesters; D017879:Isothiocyanates; D051267:NF-E2-Related Factor 2; D010091:Oximes; D013454:Sulfoxides; C016766:sulforaphane; C119494:glucoraphanin
keywords: Cancer; Chemoprevention; Nrf2; Sulforaphane