title: Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan.
abstract: To investigate the risk of hyperuricemia in relation to Perfluoroalkyl substances (PFASs) in children from Taiwan, 225 Taiwanese children aged 12-15 years were recruited from 2009 to 2010. Linear and logistic regression models were employed to examine the influence of PFASs on serum uric acid levels. Findings revealed that eight of ten PFASs analyses were detected in >94% of the participants' serum samples. Multivariate linear regression models revealed that perfluorooctanic acid (PFOA) was positively associated with serum uric acid levels (β = 0.1463, p < 0.05). Of all the PFASs analyses, only PFOA showed a significant effect on elevated levels of hyperuricemia (aOR = 2.16, 95%CI: 1.29-3.61). When stratified by gender, the association between serum PFOA and uric acid levels was only evident among boys (aOR = 2.76, 95%CI: 1.37-5.56). In conclusion, PFOA was found to be associated with elevated serum levels of uric acid in Taiwanese children, especially boys. Further research is needed to elucidate these links.
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Xiao-Di
authors.initials: XD
authors.lastname: Qin
authors.affiliation: Department of Epidemiology, College for Public Health and Social Justice, Saint Louis University, Saint Louis 63104, USA.
authors.forename: Zhengmin
authors.initials: Z
authors.lastname: Qian
authors.affiliation: School of Social Work, College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO 63104, USA.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Vaughn
authors.affiliation: School of Social Work, College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO 63104, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Epidemiology, College for Public Health and Social Justice, Saint Louis University, Saint Louis 63104, USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: Ward
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Zeng
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yuan
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Bai
authors.affiliation: Faculty of Health, School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
authors.forename: Gunther
authors.initials: G
authors.lastname: Paul
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Yuan-Tao
authors.initials: YT
authors.lastname: Hao
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.affiliation: Institute of Occupational Medicine and Industrial Hygiene and Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan, ROC; Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
authors.forename: Pau-Chung
authors.initials: PC
authors.lastname: Chen
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: donggh5@mail.sysu.edu.cn.
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Dong
authors.affiliation: Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100, Taiwan, ROC. Electronic address: leolee@ntu.edu.tw.
authors.forename: Yungling Leo
authors.initials: YL
authors.lastname: Lee
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D033461:Hyperuricemia / Q000097:blood*; D008297:Male; D013624:Taiwan; D014527:Uric Acid / Q000378:metabolism*
chemical_list: D005466:Fluorocarbons; D014527:Uric Acid
keywords: Children; Hyperuricemia; Perfluoroalkyl substances; Uric acid