title: Palladium-Catalyzed Carbonylative Four-Component Synthesis of Thiochromenones: The Advantages of a Reagent Capsule.
abstract: Multicomponent reactions, especially those involving four or even more reagents, have been a long-standing challenge because of the issues associated with balancing reactivity, selectivity, and compatibility. Herein, we demonstrate how the use of a reagent capsule provides straightforward access to synthetically valuable thiochromenone derivatives by a palladium-catalyzed carbonylative four-component reaction. To the best of our knowledge, this is the first example of applying a capsule to prevent catalyst poisoning and undesired side reactions of the multicomponent reaction.
authors.affiliation: Leibniz-Institut für Katalyse an der, Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059, Rostock, Germany.
authors.forename: Chaoren
authors.initials: C
authors.lastname: Shen
authors.affiliation: Leibniz-Institut für Katalyse an der, Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059, Rostock, Germany.
authors.forename: Anke
authors.initials: A
authors.lastname: Spannenberg
authors.affiliation: Leibniz-Institut für Katalyse an der, Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059, Rostock, Germany. xiao-feng.wu@catalysis.de.|Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, 310018, P.R. China. xiao-feng.wu@catalysis.de.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wu
keywords: carbonylation; multicomponent reactions; palladium catalysis; thiochromenones