title: "Death is my Heir"--Ferroptosis Connects Cancer Pharmacogenomics and Ischemia-Reperfusion Injury.
abstract: Although they are key to precision medicine, pharmacokinetics and pharmacogenomics are currently plagued with inconsistent results. In this issue of Cell Chemical Biology, Shimada et al. (2016) use cell line selectivity and appropriate filters to improve the consistency and to identify biomarkers for the selectivity of lethal compounds. These insights may be useful for our understanding of how necrosis and ischemic injury are regulated.
authors.affiliation: Clinic for Nephrology and Hypertension, Christian-Albrechts-University, Kiel 24105, Germany.
authors.forename: Wulf
authors.initials: W
authors.lastname: Tonnus
authors.affiliation: Clinic for Nephrology and Hypertension, Christian-Albrechts-University, Kiel 24105, Germany. Electronic address: andreas.linkermann@uksh.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Linkermann
mesh_terms: D017209:Apoptosis; D016923:Cell Death; D006801:Humans; D007511:Ischemia; D019194:Ischemic Preconditioning; D019157:Ischemic Preconditioning, Myocardial; D017202:Myocardial Ischemia; D015428:Myocardial Reperfusion Injury; D009336:Necrosis; D009369:Neoplasms; D010597:Pharmacogenetics; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D015427:Reperfusion Injury; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha
chemical_list: D014409:Tumor Necrosis Factor-alpha