title: Urinary Concentrations of Bisphenols and Their Association with Biomarkers of Oxidative Stress in People Living Near E-Waste Recycling Facilities in China.
abstract: In this study, concentrations of bisphenol A (BPA) and seven other bisphenols (BPs) were measured in urine samples collected from people living in and around e-waste dismantling facilities, and in matched reference population from rural and urban areas in China. BPA, bisphenol S (BPS), and bisphenol F (BPF) were frequently detected (detection frequencies: > 90%) in urine samples collected from individuals who live near e-waste facilities, with geometric mean (GM) concentrations of 2.99 (or 3.75), 0.361 (or 0.469), and 0.349 (or 0.435) ng/mL (or μg/g Cre), respectively; the other five BPs were rarely found in urine samples, regardless of the sampling location. The urinary concentrations of BPA and BPF, but not BPS, were significantly higher in individuals from e-waste recycling locations than did individuals from a rural reference location. Our findings indicated that e-waste dismantling activities contribute to human exposure to BPA and BPF. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) was measured in urine as a marker of oxidative stress. In the e-waste dismantling location, urinary 8-OHdG was significantly and positively correlated (p < 0.001) with urinary BPA and BPS, but not BPF; a similar correlation was also observed in reference sites. These findings suggest that BPA and BPS exposures are associated with elevated oxidative stress.
authors.affiliation: School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University , Guangzhou 510275, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany , Albany, New York 12201, United States.
authors.forename: Jingchuan
authors.initials: J
authors.lastname: Xue
authors.affiliation: School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University , Guangzhou 510275, People's Republic of China.
authors.forename: Chuan-zi
authors.initials: CZ
authors.lastname: Gao
authors.affiliation: School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University , Guangzhou 510275, People's Republic of China.
authors.forename: Rong-liang
authors.initials: RL
authors.lastname: Qiu
authors.affiliation: School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University , Guangzhou 510275, People's Republic of China.
authors.forename: Yan-xi
authors.initials: YX
authors.lastname: Li
authors.affiliation: School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University , Guangzhou 510275, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Water Resources and Environment, Guangdong Provincial Key Laboratory of Urbanization and Geo-simulation, Sun Yat-sen University , Guangzhou 510275, Peopl's Republic of China.
authors.forename: Ming-zhi
authors.initials: MZ
authors.lastname: Huang
authors.affiliation: Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany , Albany, New York 12201, United States.|Biochemistry Department, Faculty of Science and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University , Jeddah 22252, Saudi Arabia.
authors.forename: Kurunthachalam
authors.initials: K
authors.lastname: Kannan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001559:Benzhydryl Compounds / Q000652:urine*; D015415:Biomarkers / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D002681:China; D059029:Electronic Waste; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010636:Phenols / Q000652:urine*; D059027:Recycling; D013450:Sulfones / Q000652:urine; D055815:Young Adult; D000098831:Bisphenol S Compounds; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D015415:Biomarkers; D010636:Phenols; D013450:Sulfones; C543008:bisphenol S; D000098831:Bisphenol S Compounds; C006780:bisphenol A; D000098826:Bisphenol A Compounds