title: Relevant risk factors for positive lateral margin after en bloc endoscopic submucosal dissection for early gastric adenocarcinoma.
abstract: OBJECTIVE
  This study aimed to systematically assess the relevant risk factors of positive lateral margin (LM) after en bloc resection of early gastric adenocarcinoma.
  
  
  METHODS
  A total of 242 patients who had undergone endoscopic submucosal dissection (ESD) due to early gastric lesions from January 2009 to March 2015 were included in the study. Clinicopathological features of the lesions and the risk factors related to positive LM were analyzed.
  
  
  RESULTS
  The curative rate was 82.2% and positive LM was found in 12.4% of the lesions. Univariate analysis showed that positive LM was significantly associated with the tumor location (at the upper third of the stomach), size (>3 cm), histological findings, the presence of lymphovascular invasion and deeper invasion depth. Moreover, positive LM had a higher incidence of recurrent or residual tumors. A multivariate analysis showed that the location, tumor size and histological classification of tumors were independent risk factors for positive LM.
  
  
  CONCLUSIONS
  Positive LM is closely related to the upper third of stomach, a tumor larger than 3 cm and a mixed-type carcinoma. Additionally, positive LM has a predilection for recurrent or residual tumors.
authors.affiliation: Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterogy and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.
authors.forename: Qing Yan
authors.initials: QY
authors.lastname: Fu
authors.affiliation: Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterogy and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterogy and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.
authors.forename: Xiao Bo
authors.initials: XB
authors.lastname: Li
authors.affiliation: Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterogy and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.affiliation: Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterogy and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.
authors.forename: Xiao Yu
authors.initials: XY
authors.lastname: Chen
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery*; D000704:Analysis of Variance; D000069916:Endoscopic Mucosal Resection / Q000379:methods*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008297:Male; D000072662:Margins of Excision; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D018365:Neoplasm, Residual; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery*
keywords: Endoscopic mucosal dissection; positive resection margin; stomach neoplasms