title: Aged and Diseased Neurons Get Lost in Transport.
abstract: The maintenance of nucleocytoplasmic compartmentalization is essential for proper cellular function. Recent studies from the Gage and the Hipp labs report impairments in transport across the nuclear envelope in models of normal and pathological neuronal senescence, providing a mechanistic link between cerebral aging and neurodegenerative diseases.
authors.affiliation: Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Tamburrino
authors.affiliation: Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy. Electronic address: m.decressac@tigem.it.
authors.forename: Mickael
authors.initials: M
authors.lastname: Decressac
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology; D000818:Animals; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D009410:Nerve Degeneration / Q000378:metabolism / Q000473:pathology*; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D021381:Protein Transport / Q000502:physiology*
keywords: aggregates; aging; neurodegeneration; nuclear transport