title: Spherical porous hydroxyapatite granules containing composites of magnetic and hydroxyapatite nanoparticles for the hyperthermia treatment of bone tumor.
abstract: Spherical porous granules of hydroxyapatite (HA) containing magnetic nanoparticles would be suitable for the hyperthermia treatment of bone tumor, because porous HA granules act as a scaffold for bone regeneration, and magnetic nanoparticles generate sufficient heat to kill tumor cells under an alternating magnetic field. Although magnetic nanoparticles are promising heat generators, their small size makes them difficult to support in porous HA ceramics. We prepared micrometer-sized composites of magnetic and HA nanoparticles, and then supported them in porous HA granules composed of rod-like particles. The spherical porous HA granules containing the composites of magnetic and HA nanoparticle were successfully prepared using a hydrothermal process without changing the crystalline phase and heat generation properties of the magnetic nanoparticles. The obtained granules generated sufficient heat for killing tumor cells under an alternating magnetic field (300 Oe at 100 kHz). The obtained granules are expected to be useful for the hyperthermia treatment of bone tumors.
authors.affiliation: Graduate School of Environmental Studies, Tohoku University, 6-6-20 Aoba, Aramaki, Aoba-ku, Sendai, 980-8579, Japan. masanobu.kamitakahara.a6@tohoku.ac.jp.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kamitakahara
authors.affiliation: Graduate School of Environmental Studies, Tohoku University, 6-6-20 Aoba, Aramaki, Aoba-ku, Sendai, 980-8579, Japan.
authors.forename: Naohiro
authors.initials: N
authors.lastname: Ohtoshi
authors.affiliation: Graduate School of Biomedical Engineering, Tohoku University, 6-6-12 Aoba, Aramaki Aoba-ku, Sendai, 980-8579, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kawashita
authors.affiliation: Faculty of Economics, Keio University, Building #2-101B, 4-1-1, Hiyoshi, Kohoku-ku, Yokohama, 223-8521, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ioku
mesh_terms: D001859:Bone Neoplasms / Q000628:therapy*; D017886:Durapatite / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D046529:Microscopy, Electron, Transmission; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D058185:Magnetite Nanoparticles; D017886:Durapatite