title: [Filtration of active fractions with function of expelling water retention with drastic purgative from Kansui Radix stir-baked with vinegar].
abstract: To study the function of expelling water retention with drastic purgative of different polarities of Kansui Radix stir-baked with vinegar on the cancerous ascites model rats, the furosemide was taken as positive control drug, and the cancerous ascites model rats were respectively orally administered with different polarities of Kansui Radix stir-baked with vinegar for 7 d. The amount of urine and ascites, the level of urinary sodium, potassium, chloride ion and pH, and the content of PRL1, AII, ALD in serum were investigated. Compared with model groups, ethyl acetate extract group showed a decreasing trend in ascites; the amount of urine of showed a significant increase (P < 0.05); the level of urinary sodium, potassium, chloride ion (P < 0.05, P < 0.01), pH (P < 0.05), and the content of PRL1, AII, ALD in serum all showed a significant decrease (P < 0.01). The effects of petroleum ether extract and n-butanol extract were weaker than that of ethyl acetate extract. The water exact was the weakest. The results showed that ethyl acetate extract is the active part of Kansui Radix stir-baked with vinegar on the function of expelling water retention with drastic purgative on the cancerous ascites model rats, alleviating the water-electrolyte disorder and body fluid acid-base imbalance, regulating the renin angiotensin aldosterone system.
authors.forename: Liang-liang
authors.initials: LL
authors.lastname: Cao
authors.forename: Wen-xiao
authors.initials: WX
authors.lastname: Wang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: An-wei
authors.initials: AW
authors.lastname: Ding
authors.forename: Zhi-hua
authors.initials: ZH
authors.lastname: Dou
mesh_terms: D000818:Animals; D001201:Ascites / Q000188:drug therapy* / Q000378:metabolism; D002400:Cathartics / Q000008:administration & dosage* / Q000737:chemistry* / Q000302:isolation & purification; D002626:Chemistry, Pharmaceutical; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry* / Q000302:isolation & purification; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D008297:Male; D018517:Plant Roots / Q000737:chemistry; D011188:Potassium / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000652:urine; D014867:Water / Q000378:metabolism
chemical_list: D002400:Cathartics; D004365:Drugs, Chinese Herbal; D014867:Water; D012964:Sodium; D011188:Potassium