title: [The efficacy of mexidol in carotid endarterectomy procedure in patients with cerebral atherosclerotic stenosis].
abstract: OBJECTIVE
  To determine the antihypoxic efficacy of mexidol in carotid endarterectomy (CE) procedure in patients with cerebral atherosclerotic stenosis using cerebral oximetry.
  
  
  METHODS
  Clinical/psycho/neurological monitoring was performed in 109 patients with internal carotid artery stenosis of 69±7.0% and neurological symptoms of cerebral ischemia, 2-3 degree, in pre- and postoperative periods. Cerebral oximetry was carried out perioperatively. Fifty-four patients were treated with mexidol in a dose of 1000 mg/day for 14-15 days and 55 patients did not received mexidol.
  
  
  CONCLUSIONS
  The difference in initial brain oxygenation (rSO2) between the main and comparison groups was shown (60.8±5.0 and 47.29±5.5%, respectively). During operation, the degree of blood oxygenation in these groups decreased by 57% and 41%, respectively. On day 7, sinificant differences in the Schulte test in two groups of patients with similar neurological status were found considering efficiency of work and mental stability before and after operation. No differences were found in the comparison group. Mexidol used for antihypoxic brain protection in carotid endarterectomy of patients with cerebral atherosclerotic stenosis significantly reduces the degree of cerebral hypoxia, decreases the duration of surgery, improves neurological status of patients and performance of psychological tests in postoperative period.
authors.affiliation: North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg.
authors.forename: V I
authors.initials: VI
authors.lastname: Golovkin
authors.affiliation: North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg.
authors.forename: A V
authors.initials: AV
authors.lastname: Svetlikov
authors.affiliation: North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg.
authors.forename: A S
authors.initials: AS
authors.lastname: Shapovalov
authors.affiliation: North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg.
authors.forename: L O
authors.initials: LO
authors.lastname: Popova
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000098:blood supply; D002545:Brain Ischemia / Q000188:drug therapy / Q000601:surgery / Q000628:therapy; D016893:Carotid Stenosis / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D002560:Cerebrovascular Circulation; D003131:Combined Modality Therapy; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D010092:Oximetry; D059035:Perioperative Period; D010847:Picolines / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D010847:Picolines; C070020:emoxypine succinate