title: The Healing Effects of Autologous Mucosal Grafts in Experimentally Injured Rabbit Maxillary Sinuses.
abstract: OBJECTIVE
  Healing processes of the nose and paranasal sinuses are quite complex, and poorly understood. In this study, we aimed to compare the effect of mucosal autologous grafts on the degenerated rabbit maxillary sinus mucosa with spontaneous wound healing. It is hypothesized that mucosal grafts will enhance ciliogenesis and improve the morphology of regenerated cilia.
  
  
  METHODS
  Ten female New Zealand rabbits were included in the study. They underwent external maxillary sinus surgery through a transcutaneous approach. A total of 20 maxillary sinuses were randomly divided into 2 groups: 'spontaneous healing group' and 'autologous graft group.' The animals were sacrificed at the 14th day after the surgery. Scanning electron microscope (SEM), and light microscope were used for the evaluation.
  
  
  RESULTS
  Cellular composition of the graft group is better than the spontaneous healing group. The graft group had larger areas covered with ciliary epithelium than the spontaneous healing group, and the mean length of the cilias were also longer. Additionally, there were wider cilia with abnormal morphology areas in the spontaneous healing group.
  
  
  CONCLUSIONS
  In our opinion, covering of the denuded areas with a graft improves re-epithelization, and may prevent the early complications after sinus surgeries.
authors.affiliation: Department of Otorhinolaryngology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Topdag
authors.affiliation: Department of Otorhinolaryngology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kara
authors.affiliation: Department of Histology and Embryology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
authors.forename: Esma
authors.initials: E
authors.lastname: Konuk
authors.affiliation: Department of Histology and Embryology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
authors.forename: Necdet
authors.initials: N
authors.lastname: Demir
authors.affiliation: Department of Otorhinolaryngology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ozturk
authors.affiliation: Department of Otorhinolaryngology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
authors.forename: Sebla
authors.initials: S
authors.lastname: Calıskan
authors.affiliation: Department of Otorhinolaryngology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
authors.forename: Deniz Ozlem
authors.initials: DO
authors.lastname: Topdag
authors.affiliation: Department of Otorhinolaryngology, Acıbadem University Faculty of Medicine, Istanbul, Turkey.
authors.forename: Arif
authors.initials: A
authors.lastname: Ulubil
authors.affiliation: Department of Otorhinolaryngology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
authors.forename: Ibrahim Gurkan
authors.initials: IG
authors.lastname: Keskin
authors.affiliation: Department of Otorhinolaryngology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
authors.forename: Mete
authors.initials: M
authors.lastname: Iseri
keywords: Maxillary Sinus; Nasal Mucosa; Rabbits