title: Modular protein domains: an engineering approach toward functional biomaterials.
abstract: Protein domains and peptide sequences are a powerful tool for conferring specific functions to engineered biomaterials. Protein sequences with a wide variety of functionalities, including structure, bioactivity, protein-protein interactions, and stimuli responsiveness, have been identified, and advances in molecular biology continue to pinpoint new sequences. Protein domains can be combined to make recombinant proteins with multiple functionalities. The high fidelity of the protein translation machinery results in exquisite control over the sequence of recombinant proteins and the resulting properties of protein-based materials. In this review, we discuss protein domains and peptide sequences in the context of functional protein-based materials, composite materials, and their biological applications.
authors.affiliation: School of Chemical Engineering, Purdue University, West Lafayette, IN 47907-2100, USA.
authors.forename: Charng-Yu
authors.initials: CY
authors.lastname: Lin
authors.affiliation: School of Chemical Engineering, Purdue University, West Lafayette, IN 47907-2100, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907-2032, USA. Electronic address: julieliu@purdue.edu.
authors.forename: Julie C
authors.initials: JC
authors.lastname: Liu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D003432:Cross-Linking Reagents / Q000737:chemistry; D006801:Humans; D010455:Peptides / Q000737:chemistry; D000072417:Protein Domains; D015202:Protein Engineering / Q000379:methods*; D011506:Proteins / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D010455:Peptides; D011506:Proteins