title: Neisseria meningitidis Serogroup X in Sub-Saharan Africa.
abstract: The epidemiology of meningococcal disease varies by geography and time. Whole-genome sequencing of Neisseria meningitidis serogroup X isolates from sub-Saharan Africa and Europe showed that serogroup X emergence in sub-Saharan Africa resulted from expansion of particular variants within clonal complex 181. Virulence of these isolates in experimental mouse models was high.
authors.forename: Alain
authors.initials: A
authors.lastname: Agnememel
authors.forename: Eva
authors.initials: E
authors.lastname: Hong
authors.forename: Dario
authors.initials: D
authors.lastname: Giorgini
authors.forename: Viginia
authors.initials: V
authors.lastname: Nuñez-Samudio
authors.forename: Ala-Eddine
authors.initials: AE
authors.lastname: Deghmane
authors.forename: Muhamed-Kheir
authors.initials: MK
authors.lastname: Taha
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D000818:Animals; D002999:Clone Cells; D004195:Disease Models, Animal; D005060:Europe / Q000453:epidemiology; D015870:Gene Expression; D017930:Genes, Reporter; D014644:Genetic Variation; D016680:Genome, Bacterial; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008156:Luciferases / Q000235:genetics / Q000378:metabolism; D008585:Meningitis, Meningococcal / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D009345:Neisseria meningitidis / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*; D009876:Operon; D061848:Optical Imaging; D010802:Phylogeny; D065288:Serogroup; D012703:Serotyping; D014774:Virulence
chemical_list: D008156:Luciferases
keywords: Neisseria meningitidis; bacteria; emergence; meningitis; meningococci; serogroup X; sub-Saharan Africa; virulence; whole-genome sequencing