title: T Cell Response in Patients with Implanted Biological and Mechanical Prosthetic Heart Valves.
abstract: The study was aimed at assessing T cell subsets of peripheral blood from recipients of long-term functioning (more than 60 months) biological and mechanical heart valve prostheses. The absolute and relative number of CD4 and CD8 T cell subsets was analyzed: naïve (N, CD45RA(+)CD62L(+)), central memory (CM, CD45RA(-)CD62L(+)), effector memory (EM, CD45RA(-)CD62L(-)), and terminally differentiated CD45RA-positive effector memory (TEMRA, CD45RA(+)CD62L(-)) in 25 persons with biological and 7 with mechanical prosthesis compared with 48 apparently healthy volunteers. The relative and absolute number of central memory and naïve CD3(+)CD8(+) in patients with biological prosthesis was decreased (p < 0.001). Meanwhile the number of CD45RA(+)CD62L(-)CD3(+)CD8(+) and CD3(+)CD4(+) was increased (p < 0.001). Patients with mechanical prosthesis had increased absolute and relative number of CD45RA(+)CD62L(-)CD3(+)CD8(+) cells (p = 0.006). Also the relative number of CD3(+)CD4(+) cells was reduced (p = 0.04). We assume that altered composition of T cell subsets points at development of xenograft rejection reaction against both mechanical and biological heart valve prostheses.
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo 650002, Russia.
authors.forename: L
authors.initials: L
authors.lastname: Barbarash
authors.affiliation: Federal State Budgetary Institution Research Institute for Experimental Medicine, Saint Petersburg 197376, Russia; Far Eastern Federal University, Vladivostok 690091, Russia.
authors.forename: I
authors.initials: I
authors.lastname: Kudryavtsev
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo 650002, Russia.
authors.forename: N
authors.initials: N
authors.lastname: Rutkovskaya
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo 650002, Russia; Federal Almazov Medical Research Centre, Saint Petersburg 197341, Russia.
authors.forename: A
authors.initials: A
authors.lastname: Golovkin
mesh_terms: D000328:Adult; D017252:CD3 Complex / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000502:physiology; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D019041:L-Selectin / Q000378:metabolism; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000502:physiology
chemical_list: D017252:CD3 Complex; D019041:L-Selectin; D017493:Leukocyte Common Antigens