title: [COMPARATIVE SENSITIVITY OF CHOLINESTERASES IN VERTEBRATES AND INVERTEBRATES TO HIGHLY SPECIFIC ORGANOPHOSPHORUS INHIBITORS DIISOPROPYL FLUOROPHOSPHATE (DFP) AND (2-ETHOXYMETHYL PHOSPHORYL THIOETHYL) ETHYL (METHYL) SULPHONIUM SULPHOMETHYLAT (GD-42)].
abstract: The review presents data on comparative reactivity of 68 cholinesterase preparation from various organs and tissues in a number of vertebrates and invertebrates based on sensitivity to two highly specific and most studied organophosphorus inhibitors--diisopropyl fluorophosphates (DFP) and (2-ethoxymethyl phosphoryl thioethyl) ethyl (methyl) sulphonium sulphomethylat (GD-42). Analysis of these data suggests a great diversity in enzymologic characteristics of cholinesterase preparation in representatives of vertebrates and invertebrates, this variety observed even for closely related enzymes in animals of almost the same level of development.
authors.forename: N E
authors.initials: NE
authors.lastname: Basova
authors.forename: B N
authors.initials: BN
authors.lastname: Kormilitsyn
authors.forename: A Yu
authors.initials: AY
authors.lastname: Perchenok
authors.forename: E V
authors.initials: EV
authors.lastname: Rozengart
authors.forename: V S
authors.initials: VS
authors.lastname: Saakov
authors.forename: A A
authors.initials: AA
authors.lastname: Suvorov
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D002802:Cholinesterases / Q000737:chemistry*; D006801:Humans; D007531:Isoflurophate / Q000737:chemistry*; D009946:Organothiophosphorus Compounds / Q000737:chemistry*; D013045:Species Specificity
chemical_list: D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; D007531:Isoflurophate; C002674:methylsulfomethylate; D002802:Cholinesterases