title: Pepsin Egg White Hydrolysate Ameliorates Obesity-Related Oxidative Stress, Inflammation and Steatosis in Zucker Fatty Rats.
abstract: The aim of this work was to evaluate the effect of the administration of egg white hydrolysates on obesity-related disorders, with a focus on lipid metabolism, inflammation and oxidative stress, in Zucker fatty rats. Obese Zucker rats received water, pepsin egg white hydrolysate (750 mg/kg/day) or Rhizopus aminopeptidase egg white hydrolysate (750 mg/kg/day) for 12 weeks. Lean Zucker rats received water. Body weight, solid and liquid intakes were weekly measured. At the end of the study, urine, faeces, different organs and blood samples were collected. The consumption of egg white hydrolysed with pepsin significantly decreased the epididymal adipose tissue, improved hepatic steatosis, and lowered plasmatic concentration of free fatty acids in the obese animals. It also decreased plasma levels of tumor necrosis factor-alpha and reduced oxidative stress. Pepsin egg white hydrolysate could be used as a tool to improve obesity-related complications.
authors.affiliation: Instituto de Investigación en Ciencias de Alimentación (CIAL, CSIC-UAM), Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Garcés-Rimón
authors.affiliation: Departamento de Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: González
authors.affiliation: Departamento de Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Uranga
authors.affiliation: Departamento de Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain.
authors.forename: V
authors.initials: V
authors.lastname: López-Miranda
authors.affiliation: Instituto de Investigación en Ciencias de Alimentación (CIAL, CSIC-UAM), Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: López-Fandiño
authors.affiliation: Instituto de Investigación en Ciencias de Alimentación (CIAL, CSIC-UAM), Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Miguel
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000473:pathology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004529:Egg White / Q000737:chemistry; D005234:Fatty Liver / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006868:Hydrolysis; D007249:Inflammation / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009765:Obesity / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D010434:Pepsin A / Q000737:chemistry; D011924:Rats, Zucker
chemical_list: D010434:Pepsin A