title: Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response.
abstract: T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs.
authors.affiliation: Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, 1081 HV, Amsterdam, The Netherlands.
authors.forename: Maria
authors.initials: M
authors.lastname: Themeli
authors.affiliation: Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology Program, Memorial Sloan Kettering Institute, New York, NY 10065, USA. Electronic address: m-sadelain@ski.mskcc.org.
authors.forename: Michel
authors.initials: M
authors.lastname: Sadelain
mesh_terms: D000818:Animals; D060846:Cell Engineering; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D051880:Receptors, Notch / Q000737:chemistry*; D015398:Signal Transduction; D058615:Synthetic Biology / Q000379:methods*; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D051880:Receptors, Notch