title: Obstructive Sleep Apnea Is Related to Increased Arterial Stiffness in Ultrasound Speckle-Tracking Analysis.
abstract: Obstructive sleep apnea (OSA) is an independent risk factor for atherosclerosis. The aim of our study was to determine arterial stiffness in OSA patients by means of the ultrasound speckle-tracking-based method. Twenty six OSA patients and 17 control subjects were enrolled in the study. The speckle-tracking-based analysis of carotid artery included circumferential strains, circumferential strain rates, radial displacement, and radial strain rates. We found that the global average circumferential strains, circumferential strain rates, and radial displacement were significantly lower in OSA patients compared to controls (2.19 ± 0.30 % vs. 4.17 ± 0.33 %, 0.22 ± 0.03 l/s vs. 0.31 ± 0.02 l/s, 0.10 ± 0.01 mm vs. 0.16 ± 0.02 mm, respectively, p < 0.05 for all). There were no significant differences in radial strain rates between the groups (0.32 ± 0.04 % vs. 0.33 ± 0.01 %). We conclude that OSA is associated with an increased arterial stiffness.
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St., D-53105, Bonn, Germany. Izabela.Tuleta@ukb.uni-bonn.de.
authors.forename: I
authors.initials: I
authors.lastname: Tuleta
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St., D-53105, Bonn, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Skowasch
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St., D-53105, Bonn, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Krycki
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St., D-53105, Bonn, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Pizarro
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St., D-53105, Bonn, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Hammerstingl
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St., D-53105, Bonn, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Weber
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St., D-53105, Bonn, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Schahab
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St., D-53105, Bonn, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Nickenig
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St., D-53105, Bonn, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Schaefer
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St., D-53105, Bonn, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Pingel
mesh_terms: D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology*; D014463:Ultrasonography; D059289:Vascular Stiffness
keywords: Functional vessel damage; Intermittent nocturnal hypoxia; Vascular incompliance; Vessel wall deformation; Vessel wall motion