title: The "Pure Marriage" between 3D Printing and Well-Ordered Nanoarrays by Using PEALD Assisted Hydrothermal Surface Engineering.
abstract: For the first time, homogeneous and well-ordered functional nanoarrays were grown densely on the complex structured three-dimensional (3D) printing frameworks through a general plasma enhanced atomic layer deposition (PEALD) assisted hydrothermal surface engineering process. The entire process was free from toxic additives or harmful residues and, therefore, can meet the critical requirements of high-purity products. As a practical example, 3D customized earplugs were precisely manufactured according to the model of ear canals at the 0.1 mm level. Meanwhile, well-ordered ZnO nanoarrays, formed on the surfaces of these 3D printed earplugs, could effectively prevent the growth of five main pathogens derived from the patients with otitis media and exhibited excellent wear resistance as well. On the basis of both animal experiments and volunteers' investigations, the 3D customized earplugs showed sound insulation capabilities superior to those of traditional earplugs. Further animal experiments demonstrated the potential of as-modified implant scaffolds in practical clinical applications. This work, exemplified with earplugs and implant scaffolds, oriented the development direction of 3D printing in biomedical devices, which precisely integrated customized architecture and tailored surface performance.
authors.affiliation: Institute of Translational Medicine, Nanchang University , Nanchang, Jiangxi 330088 People's Republic of China.
authors.forename: Chaowen
authors.initials: C
authors.lastname: Xue
authors.affiliation: Institute of Translational Medicine, Nanchang University , Nanchang, Jiangxi 330088 People's Republic of China.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Shi
authors.affiliation: State Key Laboratory of High Power Semiconductor Laser, Changchun University of Science and Technology , Changchun, Jilin 130022 People's Republic of China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Fang
authors.affiliation: State Key Laboratory of High Power Semiconductor Laser, Changchun University of Science and Technology , Changchun, Jilin 130022 People's Republic of China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Tao
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun, Jilin 130022 People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Institute of Translational Medicine, Nanchang University , Nanchang, Jiangxi 330088 People's Republic of China.
authors.forename: Fen
authors.initials: F
authors.lastname: Yu
authors.affiliation: Institute of Translational Medicine, Nanchang University , Nanchang, Jiangxi 330088 People's Republic of China.
authors.forename: Xingwei
authors.initials: X
authors.lastname: Ding
authors.affiliation: Institute of Translational Medicine, Nanchang University , Nanchang, Jiangxi 330088 People's Republic of China.
authors.forename: Miaoxing
authors.initials: M
authors.lastname: Liu
authors.affiliation: National Engineering Technology Research Center for LED on Si Substrate, Nanchang University , Nanchang, Jiangxi 330047 People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Fang
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun, Jilin 130022 People's Republic of China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: State Key Laboratory of High Power Semiconductor Laser, Changchun University of Science and Technology , Changchun, Jilin 130022 People's Republic of China.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Wei
authors.affiliation: Institute of Translational Medicine, Nanchang University , Nanchang, Jiangxi 330088 People's Republic of China.
authors.forename: Tingtao
authors.initials: T
authors.lastname: Chen
authors.affiliation: Key Laboratary of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun, Jilin 130022 People's Republic of China.
authors.forename: Zongliang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Power and Mechanical Engineering, Wuhan University , Wuhan, Hubei 430072, People's Republic of China.
authors.forename: Guoping
authors.initials: G
authors.lastname: Wang
authors.affiliation: First Department of Orthopedics, Second Affiliated Hospital of Nanchang University Nanchang, Jiangxi 330006, People's Republic of China.
authors.forename: Xigao
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Department of Chemistry, Nanchang University , Nanchang 330031, People's Republic of China.
authors.forename: Junchao
authors.initials: J
authors.lastname: Wei
authors.affiliation: Jeatech Company for 3D Scanning , Guangzhou, 510000 People's Republic of China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Institute of Translational Medicine, Nanchang University , Nanchang, Jiangxi 330088 People's Republic of China.
authors.forename: Keyu
authors.initials: K
authors.lastname: Deng
authors.affiliation: Institute of Translational Medicine, Nanchang University , Nanchang, Jiangxi 330088 People's Republic of China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Institute of Translational Medicine, Nanchang University , Nanchang, Jiangxi 330088 People's Republic of China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Xin
mesh_terms: D000818:Animals; D004424:Ear Canal / Q000503:physiopathology; D004430:Ear Protective Devices; D006801:Humans; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use; D010033:Otitis Media / Q000382:microbiology / Q000628:therapy*; D058626:Plasma Gases; D066330:Printing, Three-Dimensional; D054457:Tissue Scaffolds; D015034:Zinc Oxide / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D058626:Plasma Gases; D015034:Zinc Oxide
keywords: 3D printing; Hydrothermal synthesis; nanostructures; surface engineering; zinc oxide