title: Possible roles of platelet-derived microparticles in atherosclerosis.
abstract: Platelets and platelet-derived microparticles (PMPs) play important roles in cardiovascular diseases, especially atherosclerosis. Continued research has revealed that PMPs have numerous functions in atherosclerosis, not only in thrombosis formation, but also by induction of inflammation. PMPs also induce formation of foam cells. Recent evidence strongly indicates a significant role of PMPs in atherosclerosis. Here, current research on the function of PMPs in atherosclerosis is reviewed.
authors.affiliation: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Zhi-Ting
authors.initials: ZT
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Fudan University, Shanghai 201203, China.
authors.forename: Zi
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address: ywhu0618@163.com.
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Hu
mesh_terms: D050197:Atherosclerosis / Q000097:blood*; D015415:Biomarkers / Q000378:metabolism; D001777:Blood Coagulation; D001792:Blood Platelets / Q000166:cytology*; D002448:Cell Adhesion; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D005487:Foam Cells / Q000166:cytology; D006801:Humans; D007249:Inflammation; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D009369:Neoplasms / Q000378:metabolism; D015539:Platelet Activation
chemical_list: D015415:Biomarkers; D008055:Lipids
keywords: Atherosclerosis; Foam cells; Inflammation; PMPs; Thrombosis formation