title: NLRP3 Is Involved in Ischemia/Reperfusion Injury.
abstract: Inflammation plays a pivotal role in the ischemia/reperfusion (I/R) injury. Inflammatory response is initiated by the detection of pathogen-associated molecular patterns and/or damage-associated molecular patterns via extracellular and intracellular pattern recognition receptors. The nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing protein 3 (NLRP3) is a component of pattern recognition receptors and serves a vital role in inflammatory response by forming an intracellular multi-protein complex known as NLRP3 inflammasome. There is increasing evidence that NLRP3 inflammasome acts as guardians against host-derived danger materials. The inappropriate activation of NLRP3 contributes to the progression of I/R injury such as myocardial, cerebral, renal, hepatic and retinal I/R injuries. In this review, we summarize the role of NLRP3 in inflammatory response and discuss the relationship between NLRP3 and I/R injury. We also provide insights into new treatment strategies for targeting NLRP3 inflammasome, as well as the upstream and downstream components of NLRP3 in alleviating I/R injury.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Guo
authors.forename: Shuhong
authors.initials: S
authors.lastname: Yu
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Ruidong
authors.initials: R
authors.lastname: Ye
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China. zwsemail@sina.com.
authors.forename: Wusheng
authors.initials: W
authors.lastname: Zhu
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D006801:Humans; D058847:Inflammasomes / Q000187:drug effects / Q000378:metabolism*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein / Q000378:metabolism*; D015427:Reperfusion Injury / Q000188:drug therapy / Q000276:immunology*
chemical_list: D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein