title: Expression of γ-Synuclein in Bladder Carcinoma: A Possible Marker for Prognosis.
abstract: OBJECTIVE
  To investigate if γ-synuclein (SNCG) could be used as a bladder cancer (BC) marker to predict prognosis of BC.
  
  
  METHODS
  Medical records of 140 patients with BC (January, 2006 to December, 2009) were retrospectively reviewed. SNCG expression level was examined by immunohistological staining. The patients' survival rate was calculated by the Kaplan-Meier method. Cox proportional regression model was used to identify independent predictors for BC.
  
  
  RESULTS
  Overexpression of SNCG was detected in BC tissues and the expression level of SNCG strongly positively correlated with BC recurrence. However, no correlation was found between SNCG level and tumor stage or survival rate.
  
  
  CONCLUSIONS
  SNCG is a good marker to predict recurrence of BC, but not a reliable marker for staging or prediction of survival rate.
authors.affiliation: Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Ji
authors.affiliation: Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China shibbpumch@126.com yujiang.fang@dmu.edu.
authors.forename: Bingbing
authors.initials: B
authors.lastname: Shi
authors.affiliation: Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Chengchao
authors.initials: C
authors.lastname: Shou
authors.affiliation: Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Caiyun
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Hanzhong
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA, U.S.A.
authors.forename: Kristoffer T
authors.initials: KT
authors.lastname: Davidson
authors.affiliation: Department of Surgery, University of Missouri, Columbia, MO, U.S.A.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Wakefield
authors.affiliation: Department of Surgery, University of Missouri, Columbia, MO, U.S.A.
authors.forename: Tyler W
authors.initials: TW
authors.lastname: Ball
authors.affiliation: Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA, U.S.A. Department of Surgery, University of Missouri, Columbia, MO, U.S.A. shibbpumch@126.com yujiang.fang@dmu.edu.
authors.forename: Yujiang
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism*; D016016:Proportional Hazards Models; D015996:Survival Rate; D015854:Up-Regulation; D001743:Urinary Bladder / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult; D051845:gamma-Synuclein / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; C104249:SNCG protein, human; D051845:gamma-Synuclein
keywords: bladder carcinoma; prognosis; recurrence; γ-Synuclein