title: Microarray analysis of microRNA expression in bone marrow-derived progenitor cells from mice with type 2 diabetes.
abstract: Bone-marrow derived vascular precursors are an important endogenous repair reservoir for vascular repair and neovascularization [1]. Therapies of stem/progenitor cells targeting on angiogenesis are considered hopeful solutions for tissue repair and regeneration. However, the dysfunction of patient-derived progenitor cells has been implicated in diabetes [2], which limited the efficacy of autologous cell therapies in the clinic [3,4]. MicroRNAs are important gene regulators whose functions remain largely unknown. In this project we reported the different microRNA expression profiles in bone marrow-derived progenitor cells from type 2 diabetic mice and their normal controls using microRNA array analysis. All microarray data are available at the Gene Expression Omnibus (GEO) at NCBI (http://www.ncbi.nlm.nih.gov/geo), under accession number GSE72616.
authors.affiliation: Center for Molecular Medicine and Genetics, Department of Immunology, Wayne State University, United States.
authors.forename: Jie-Mei
authors.initials: JM
authors.lastname: Wang
authors.affiliation: Center for Molecular Medicine and Genetics, Department of Immunology, Wayne State University, United States.
authors.forename: Kezhong
authors.initials: K
authors.lastname: Zhang