title: The Microbiome in Necrotizing Enterocolitis: A Case Report in Twins and Minireview.
abstract: Our case describes the serial microbiome changes in twins discordant for necrotizing enterocolitis (NEC), who shared similar intrauterine and early environmental exposures. The key findings were that the 2 neonates had distinctly different microbiome compositions from the first stool samples collected. Also, in the twin who developed NEC there was a decrease in bacterial diversity and an increase in Proteobacteria a week before developing any clinical symptoms, suggesting an early role of the intestinal microbiome in the development of NEC. Here we briefly review the literature on the role of the intestinal microbiome in NEC and how a greater understanding of the neonatal microbiome and host interactions may help mitigate this devastating disease.
authors.affiliation: Inova Translational Medicine Institute, Fairfax, Virginia; Inova Children's Hospital, Fairfax, Virginia; Pediatric Specialists of Virginia, Fairfax, Virginia; Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address: suchihourigan@gmail.com.
authors.forename: Suchitra K
authors.initials: SK
authors.lastname: Hourigan
authors.affiliation: Inova Children's Hospital, Fairfax, Virginia.
authors.forename: Allison
authors.initials: A
authors.lastname: Ta
authors.affiliation: Inova Translational Medicine Institute, Fairfax, Virginia.
authors.forename: Wendy S W
authors.initials: WS
authors.lastname: Wong
authors.affiliation: Inova Translational Medicine Institute, Fairfax, Virginia.
authors.forename: Nicole C
authors.initials: NC
authors.lastname: Clemency
authors.affiliation: Inova Translational Medicine Institute, Fairfax, Virginia.
authors.forename: Marina G
authors.initials: MG
authors.lastname: Provenzano
authors.affiliation: Inova Translational Medicine Institute, Fairfax, Virginia.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Baveja
authors.affiliation: Inova Translational Medicine Institute, Fairfax, Virginia.
authors.forename: Ramaswamy
authors.initials: R
authors.lastname: Iyer
authors.affiliation: Inova Translational Medicine Institute, Fairfax, Virginia.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Klein
authors.affiliation: Inova Translational Medicine Institute, Fairfax, Virginia; Johns Hopkins School of Medicine, Baltimore, Maryland.
authors.forename: John E
authors.initials: JE
authors.lastname: Niederhuber
mesh_terms: D020345:Enterocolitis, Necrotizing; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007231:Infant, Newborn; D014427:Twins
keywords: intestinal microbiome; necrotizing enterocolitis; neonate; twins