title: Lysosomes relax in the cellular suburbs.
abstract: Lysosomes support cellular homeostasis by degrading macromolecules and recycling nutrients. In this issue, Johnson et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507112) reveal a heterogeneity in lysosomal pH and degradative ability that correlates with lysosome subcellular localization, raising questions about the functional implications and mechanisms underlying these observations.
authors.affiliation: Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510 Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: Swetha
authors.initials: S
authors.lastname: Gowrishankar
authors.affiliation: Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510 Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510 shawn.ferguson@yale.edu.
authors.forename: Shawn M
authors.initials: SM
authors.lastname: Ferguson
mesh_terms: D006801:Humans; D008247:Lysosomes / Q000502:physiology*