title: Synthesis of Organofluoro Compounds Using Methyl Perfluoroalk-2-ynoates as Building Blocks.
abstract: This review provides an overview of several synthetic applications of methyl perfluoroalk-2-ynoates, leading to convenient preparation of many perfluoroalkylated compounds. The use of these important substrates in the synthesis of various five-, six-, and seven-membered heterocycles, cyclopentadienes, and biphenyls is described, alongside a discussion of the mechanistic aspects of these reactions.
authors.affiliation: Department of Chemistry, Innovative Drug Research Center Shanghai University, Shanghai, 200444, P. R. China.
authors.forename: Xuechun
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Chemistry, Innovative Drug Research Center Shanghai University, Shanghai, 200444, P. R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Chemistry, Innovative Drug Research Center Shanghai University, Shanghai, 200444, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Innovative Drug Research Center Shanghai University, Shanghai, 200444, P. R. China.|Laboratory for Microstructures, Instrumental Analysis and Research Center of Shanghai University, Shanghai, 200444, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Innovative Drug Research Center Shanghai University, Shanghai, 200444, P. R. China.|Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, 200032, P. R. China.|Key Laboratory of Synthetic Organic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, 200032, P. R. China.|State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, 200032, P. R. China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Cao
keywords: Michael addition; drug design; fluorine; perfluoroalkyl groups; synthetic methods