title: Thromboelastographic evidence of inhibition of fibrinolysis after ε-aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy.
abstract: OBJECTIVE
  To describe the thromboelastographic changes in fibrinolysis with ε-aminocaproic acid treatment in a dog with suspected acute traumatic coagulopathy.
  
  
  METHODS
  A 9-year-old female spayed Airedale Terrier was presented with multiple injuries consistent with motor vehicle trauma. After surgical repair of a diaphragmatic hernia and minor laceration of the right cranial lung lobe, the dog continued to produce copious volumes of hemorrhagic fluid from the thoracic cavity despite multiple plasma transfusions, autotransfusions, and failure to locate a definitive source of bleeding during 2 separate surgeries. ε-Aminocaproic acid treatment was initiated and was associated with rapid clinical improvement and diminished fibrinolysis based on a modified plasma-based thromboelastogram.
  
  
  CONCLUSIONS
  This report describes thromboelastographic evidence of inhibition of fibrinolysis after ε-aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy. Thromboelastrography may be useful in monitoring therapy with antifibrinolytic drugs.
authors.affiliation: Department of Microbiology, Immunology and Pathology, Fort Collins, CO.
authors.forename: Seung H
authors.initials: SH
authors.lastname: Yoo
authors.affiliation: College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO.
authors.forename: Emilee
authors.initials: E
authors.lastname: Venn
authors.affiliation: College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Sullivan
authors.affiliation: Department of Microbiology, Immunology and Pathology, Fort Collins, CO. christine.olver@colostate.edu.
authors.forename: Christine S
authors.initials: CS
authors.lastname: Olver
mesh_terms: D015119:Aminocaproic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001778:Blood Coagulation Disorders / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D013916:Thrombelastography / Q000662:veterinary
chemical_list: D000933:Antifibrinolytic Agents; D015119:Aminocaproic Acid
keywords: acute coagulopathy of trauma-shock; antifibrinolysis; canine; thromboelastography; trauma-induced coagulopathy