title: Relationship between Serum Inflammatory Marker and Bone Mineral Density in Healthy Adults.
abstract: BACKGROUND
  Inflammatory markers have been shown to play an important role in bone remodeling. The purpose of this study was to investigate the relationship among serum C-reactive protein (CRP), adiponectin, tumor necrosis factor-alpha (TNF-α) and bone health in healthy adults.
  
  
  METHODS
  We measured serum levels of CRP, adiponectin, TNF-α as well as lumbar spine and femoral neck bone mineral density (BMD) in 76 adults. Anthropometric measurements and nutrient intake survey of participants were carried out. The participants were divided into two groups (normal BMD group=40; 52.6%, decreased BMD group=36; 47.4%).
  
  
  RESULTS
  The CRP concentration was significantly higher in the decreased BMD group. The adiponectin concentration was lower in the decreased BMD group but the difference was not significant. The TNF-α concentration was higher in the decreased BMD group, the difference was not significant. The participants in the decreased BMD group were found to have lower calcium intakes. The sodium intake of the decreased BMD group was significantly higher. The BMD in the decreased BMD group showed inverse correlations with CRP and dietary sodium intake.
  
  
  CONCLUSIONS
  Serum CRP and dietary sodium intake is associated with BMD. Further research is needed to confirm the potential role of inflammatory marker to modulate the effects on bone.
authors.affiliation: Department of Preventive Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.; Department of Clinical Nutrition, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
authors.forename: Hee-Sook
authors.initials: HS
authors.lastname: Lim
authors.affiliation: Department of Preventive Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Yoon-Hyung
authors.initials: YH
authors.lastname: Park
authors.affiliation: Department of Food Sciences & Nutrition, Soonchunhyang University, Asan, Korea.
authors.forename: Soon-Kyung
authors.initials: SK
authors.lastname: Kim
keywords: Adiponectin; Bone Density; C-reactive protein; Nutritional status