title: Carbon-Quantum-Dots-Loaded Mesoporous Silica Nanocarriers with pH-Switchable Zwitterionic Surface and Enzyme-Responsive Pore-Cap for Targeted Imaging and Drug Delivery to Tumor.
abstract: Mesoporous silica nanocarriers with pH-switchable antifouling zwitterionic surface, enzyme responsive drug release properties and blue fluorescence are reported. Prolonged circulation in the blood system with zero premature release as well as efficient cellular uptake and intracellular drug release in tumor tissue are achieved.
authors.affiliation: Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
authors.forename: Zhongning
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Chemical Engineering and Technology, Shanxi Key Laboratory of Energy Chemical Process Intensification, Xi'an Jiaotong University, Xi'an, 710049, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, China.
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Australian Centre for NanoMedicine, University of New South Wales, Sydney, 2052, Australia.
authors.forename: John Justin
authors.initials: JJ
authors.lastname: Gooding
authors.affiliation: Department of Prosthodontics, National Engineering Lab for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016062:Porosity; D045663:Quantum Dots / Q000737:chemistry / Q000627:therapeutic use; D012822:Silicon Dioxide / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D012822:Silicon Dioxide
keywords: dual-stimuli responsiveness; mesoporous silica nanocarriers; selective cell imaging; switchable antifouling; tumor targeting drug delivery