title: Left Atrial Appendage Occlusion in Non-Valvular Atrial Fibrillation in a Korean Multi-Center Registry.
abstract: BACKGROUND
  The aim of this study was to evaluate clinical outcome after left atrial appendage (LAA) occlusion in real clinical practice and compare between Amplatzer cardiac plug (ACP) and Watchman.
  
  
  RESULTS
  From October 2010 to February 2015, 96 successful LAA occlusion procedures were performed using either ACP (n=50) or Watchman device (n=46) in non-valvular atrial fibrillation (AF) patients (59 male; age, 65.1±9.4 years; CHADS2, 2.5±1.2; CHA2DS2-VASC, 3.9±1.6; HAS-BLED, 2.7±1.3). The procedure success rate was 96.8%. There were serious complications in 4 patients (4.1%; 2 cardiac tamponade, 1 device embolization, and 1 major bleed). The anticoagulation cessation rate after 6 weeks was 92.7%. During mean 21.9-month follow-up, the incidence of death, stroke, systemic embolization and major bleeding was 5.2%, 4.2%, 0% and 1.0%, respectively. On transesophageal echocardiography of 93 patients within 6 months after the procedure, 24 residual leaks were observed (25.8%; 2 mild, 18 moderate, and 4 major). Clinical outcome was similar for the 2 devices, but peridevice leakage was more frequent with the Watchman than the ACP.
  
  
  CONCLUSIONS
  LAA occlusion was feasible in non-valvular AF patients with high risk of stroke and hemorrhage. The ACP and Watchman devices were similar in terms of procedural and clinical outcomes. (Circ J 2016; 80: 1123-1130).
authors.affiliation: Severance Cardiovascular Hospital, Yonsei University College of Medicine.
authors.forename: Jung-Sun
authors.initials: JS
authors.lastname: Kim
authors.forename: Hancheol
authors.initials: H
authors.lastname: Lee
authors.forename: Yongsung
authors.initials: Y
authors.lastname: Suh
authors.forename: Hui-Nam
authors.initials: HN
authors.lastname: Pak
authors.forename: Geu-Ru
authors.initials: GR
authors.lastname: Hong
authors.forename: Chi Young
authors.initials: CY
authors.lastname: Shim
authors.forename: Cheol-Woong
authors.initials: CW
authors.lastname: Yu
authors.forename: Hyun-Jong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Woong-Chol
authors.initials: WC
authors.lastname: Kang
authors.forename: Eun-Seok
authors.initials: ES
authors.lastname: Shin
authors.forename: Rak-Kyeong
authors.initials: RK
authors.lastname: Choi
authors.forename: Saibal
authors.initials: S
authors.lastname: Kar
authors.forename: Jai-Wun
authors.initials: JW
authors.lastname: Park
authors.forename: Do-Sun
authors.initials: DS
authors.lastname: Lim
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
mesh_terms: D000368:Aged; D020517:Atrial Appendage / Q000601:surgery*; D001281:Atrial Fibrillation / Q000150:complications* / Q000601:surgery; D004864:Equipment and Supplies / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries; D056910:Republic of Korea; D020521:Stroke / Q000517:prevention & control; D016896:Treatment Outcome