title: The Acquisition of Cell Fate in Mouse Development: How Do Cells First Become Heterogeneous?
abstract: Specification of cell fate in the early mouse embryo involves the generation of heterogeneities between cells in polarity, position, gene expression, and protein activity. Identifying when and how these differences first become established represents an important challenge for understanding the roles of stochastic and cell history-dependent mechanisms in mammalian development.
authors.affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Sarah J L
authors.initials: SJ
authors.lastname: Graham
authors.affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom. Electronic address: mz205@cam.ac.uk.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zernicka-Goetz
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D004622:Embryo, Mammalian / Q000166:cytology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D015398:Signal Transduction
keywords: Blastocyst; Cell fate; Differentiation; Mouse embryo; Pluripotency; Preimplantation