title: A successful approach to overcome imatinib-induced skin toxicity in a GIST patient.
abstract: Since the introduction of tyrosine kinase inhibitors in gastrointestinal stromal tumor patients, the median survival of patients has increased from less than 1 to more than 5 years. The chronic use of a tyrosine kinase inhibitor has an impact on quality of life because of its toxicity. Adequate supportive therapy is therefore important. We describe a female patient with a metastatic gastrointestinal stromal tumor. During treatment with the c-KIT inhibitor imatinib, she developed severe therapy-limiting skin toxicity. After several different supportive attempts, the combination of doxycycline and clemastine proved to be the solution, enabling successful chronic treatment with imatinib. Chronic use of doxycycline and clemastine is useful in the management of skin toxicity caused by c-KIT inhibitors, enabling the needed long-term use of these kind of anticancer drugs without hampering the quality of life.
authors.affiliation: Departments of aMedical Oncology bPharmacy cDermatology, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Ingrid M E
authors.initials: IM
authors.lastname: Desar
authors.forename: Carla M L
authors.initials: CM
authors.lastname: van Herpen
authors.forename: Nielka P
authors.initials: NP
authors.lastname: van Erp
authors.forename: Suzanne E J
authors.initials: SE
authors.lastname: Kaal
authors.forename: Peter C M
authors.initials: PC
authors.lastname: van de Kerkhof
authors.forename: Winette T A
authors.initials: WT
authors.lastname: van der Graaf
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002974:Clemastine / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D000068877:Imatinib Mesylate / Q000009:adverse effects* / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D012871:Skin Diseases / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D000068877:Imatinib Mesylate; D002974:Clemastine; D004318:Doxycycline