title: Perceived function and physical performance are associated with pain and fatigue in women with fibromyalgia.
abstract: BACKGROUND
  Fibromyalgia is a condition characterized by chronic widespread muscle pain and fatigue and associated with significant impairment in perceived function and reduced physical performance. The purpose of this study was to determine the degree to which pain and fatigue are associated with perceived function and physical performance in women with fibromyalgia.
  
  
  METHODS
  Hierarchical linear regression determined the contribution of pain and fatigue (Numeric Rating Scale (NRS) for resting, movement and combined) to perceived function (Fibromyalgia Impact Questionnaire Revised - Function Subscale, FIQR-Function), Multidimensional Assessment of Fatigue - Activities of Daily Living (MAF-ADL) and SF-36 Physical Function Subscale (SF-36-PF) and physical performance (6-Minute Walk Test, 6MWT and Five Time Sit To Stand, 5TSTS) while controlling for age, body mass index, pain catastrophizing, fear of movement, anxiety, and depression in women with fibromyalgia (N = 94).
  
  
  RESULTS
  For perceived function, movement pain and movement fatigue together better predicted FIQR-function (adjusted R(2) = 0.42, p ≤ 0.001); MAF-ADL (adjusted R(2) = 0.41, p ≤ 0.001); and SF-36-PF function (adjusted R(2) = 0.34, p ≤ 0.001). For physical performance measures, movement pain and fatigue together predicted 6MWT distance (adjusted R(2) = 0.42, p ≤ 0.001) and movement fatigue alone predicted performance time on the 5TSTS (adjusted R(2) = 0.20, p ≤ 0.001).
  
  
  CONCLUSIONS
  Pain and fatigue are significantly associated with and explain more than one-third of the variance in perceived function and physical performance in women with fibromyalgia.
  
  
  BACKGROUND
  NIH Clinicaltrials.gov
  
  
  BACKGROUND
  NCT01888640 . Registered 13 June 2013.
authors.affiliation: Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, 1-252 MEB, 500 Newton Road, Iowa City, IA, 52242, USA. dana-dailey@uiowa.edu.|Department of Physical Therapy and Rehabilitation Science, 1-242 MEB, Carver College of Medicine, University of Iowa, 375 Newton Road, Iowa City, IA, 52422, USA. dana-dailey@uiowa.edu.
authors.forename: Dana L
authors.identifier: http://orcid.org/0000-0002-1239-7530
authors.initials: DL
authors.lastname: Dailey
authors.affiliation: Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, 1-252 MEB, 500 Newton Road, Iowa City, IA, 52242, USA.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Frey Law
authors.affiliation: Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, 1-252 MEB, 500 Newton Road, Iowa City, IA, 52242, USA.
authors.forename: Carol G T
authors.initials: CG
authors.lastname: Vance
authors.affiliation: Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, 1-252 MEB, 500 Newton Road, Iowa City, IA, 52242, USA.|College of Nursing, University of Iowa, 50 Newton Road, Iowa City, IA, 52242, USA.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Rakel
authors.affiliation: Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, 1-252 MEB, 500 Newton Road, Iowa City, IA, 52242, USA.
authors.forename: Ericka N
authors.initials: EN
authors.lastname: Merriwether
authors.affiliation: Department of Medicine, Division of Rheumatology & Immunology, Vanderbilt University, 1161 21st Avenue South, Nashville, TN, 37232, USA.
authors.forename: Leon
authors.initials: L
authors.lastname: Darghosian
authors.affiliation: Department of Medicine, Division of Rheumatology & Immunology, Vanderbilt University, 1161 21st Avenue South, Nashville, TN, 37232, USA.
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Golchha
authors.affiliation: Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, 1-252 MEB, 500 Newton Road, Iowa City, IA, 52242, USA.
authors.forename: Katharine M
authors.initials: KM
authors.lastname: Geasland
authors.affiliation: Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, 1-252 MEB, 500 Newton Road, Iowa City, IA, 52242, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Spitz
authors.affiliation: Department of Medicine, Division of Rheumatology & Immunology, Vanderbilt University, 1161 21st Avenue South, Nashville, TN, 37232, USA.
authors.forename: Leslie J
authors.initials: LJ
authors.lastname: Crofford
authors.affiliation: Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, 1-252 MEB, 500 Newton Road, Iowa City, IA, 52242, USA.|College of Nursing, University of Iowa, 50 Newton Road, Iowa City, IA, 52242, USA.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Sluka
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D000368:Aged; D059350:Chronic Pain / Q000453:epidemiology* / Q000209:etiology; D005221:Fatigue / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005356:Fibromyalgia / Q000150:complications* / Q000523:psychology; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D010465:Perception; D012720:Severity of Illness Index; D004561:Transcutaneous Electric Nerve Stimulation; D055815:Young Adult