title: Nodular amyloidosis.
abstract: Nodular amyloidosis is the rarest form of primary cutaneous amyloidosis. We report the case of a 74-year-old woman with an eight-year history of asymptomatic, hyperpigmented plaques on the pretibial areas. A skin biopsy specimen showed deposits of amorphous eosinophilic material that extended throughout the dermis with apple-green birefringence with a Congo-red stain, which established a diagnosis of nodular amyloidosis. Patients with nodular amyloidosis should be evaluated for systemic disease and followed appropriately due to a small risk of progression to systemic amyloidosis.
authors.affiliation: New York University School of Medicine.
authors.forename: Forrest
authors.initials: F
authors.lastname: White
authors.forename: Marianna
authors.initials: M
authors.lastname: Shvartsbeyn
authors.forename: Shane A
authors.initials: SA
authors.lastname: Meehan
authors.forename: Sarika
authors.initials: S
authors.lastname: Ramachandran
mesh_terms: D000368:Aged; D028226:Amyloidosis, Familial / Q000175:diagnosis*; D001706:Biopsy; D018450:Disease Progression; D005260:Female; D006801:Humans; D012867:Skin / Q000473:pathology*; D012873:Skin Diseases, Genetic / Q000175:diagnosis*