title: [CHARACTERIZATION OF THE CELLULAR COMPOSITION OF THE MUCOSAL LAMINA PROPRIA OF THE JEJUNUM IN MICE SUBJECTED TO THE CONDITIONS SIMULATING LONG-DURATION SPACEFLIGHT].
abstract: The cellular composition of the lamina propria of the mucous membrane of the jejunum was examined in the villi (LPV) and between the crypts (LPC). Two groups of male C57/BL6 mice aged 4-5 months were studied. Experimental group of animals (n=8) for 30 days was living under the terrestrial conditions in "BIOS-SLA" blocks and received a paste-like food made with standard feed containing water and casein. The control group of animals (n=6) were kept in standard vivarium conditions and received standard dry pellets. Studies have shown no significant changes in the content of lymphocytes in LPV and LPC in a terrestrial experiment. LPV was characterized by a sharp reduction in the number of plasma cells. In both LPV and LPC the number of eosinophils was increased, while the content of low differentiated forms of cells (blasts and large lymphocytes) was decreased. It is suggested that the changes in the contents of different cell types in ground-based experiment were due not only to the limited mobility of the animals but also to different composition of the feed.
authors.forename: G G
authors.initials: GG
authors.lastname: Aminova
authors.forename: M R
authors.initials: MR
authors.lastname: Sapinj
authors.forename: L M
authors.initials: LM
authors.lastname: Yerofeyeva
mesh_terms: D000818:Animals; D007413:Intestinal Mucosa / Q000473:pathology / Q000503:physiopathology*; D007583:Jejunum / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D013026:Space Flight; D013997:Time Factors; D014893:Weightlessness / Q000009:adverse effects*; D018474:Weightlessness Simulation