title: Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system.
abstract: OBJECTIVE
  To determine the predictive value and feasibility of the new outcome prediction model for Chinese patients with penile squamous cell carcinoma.
  
  
  RESULTS
  The 3-year disease-speciﬁc survival (DSS) survival (DSS) was 92.3% in patients with < 8.70 mg/L CRP and 54.9% in those with elevated CRP (P < 0.001). The 3-year DSS was 86.5% in patients with a BMI < 22.6 Kg/m2 and 69.9% in those with a higher BMI (P = 0.025). In a multivariate analysis, pathological T stage (P < 0.001), pathological N stage (P = 0.002), BMI (P = 0.002), and CRP (P = 0.004) were independent predictors of DSS. A new scoring model was developed, consisting of BMI, CRP, and tumor T and N classiﬁcation. In our study, we found that the addition of the above-mentioned parameters significantly increased the predictive accuracy of the system of the American Joint Committee on Cancer (AJCC) anatomic stage group. The accuracy of the new prediction category was verified.
  
  
  METHODS
  A total of 172 Chinese patients with penile squamous cell cancer were analyzed retrospectively between November 2005 and November 2014. Statistical data analysis was conducted using the nonparametric method. Survival analysis was performed with the log-rank test and the Cox proportional hazard model. Based on regression estimates of signiﬁcant parameters in multivariate analysis, a new BMI-, CRP- and pathologic factors-based scoring model was developed to predict disease--speciﬁc outcomes. The predictive accuracy of the model was evaluated using the internal and external validation.
  
  
  CONCLUSIONS
  The present study demonstrated that the TNCB score group system maybe a precise and easy to use tool for predicting outcomes in Chinese penile squamous cell carcinoma patients.
authors.affiliation: Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.|State Key Laboratory of Oncology in Southern China, Guangzhou, P. R. China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, P. R. China.
authors.forename: Zai-Shang
authors.initials: ZS
authors.lastname: Li
authors.affiliation: Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumchi, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.|State Key Laboratory of Oncology in Southern China, Guangzhou, P. R. China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, P. R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yao
authors.affiliation: Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, P. R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, P. R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Urology, Dong Guan People's Hospital, Guang Dong, P. R. China.
authors.forename: Qi-Wu
authors.initials: QW
authors.lastname: Mi
authors.affiliation: Department of Urology,The First People's Hospital of Chenzhou, Chenzhou, P. R. China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Chen
authors.affiliation: School of Life Science, Sun Yat-sen University, School of Life Science, Guang Dong, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.|State Key Laboratory of Oncology in Southern China, Guangzhou, P. R. China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, P. R. China.
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Li
authors.affiliation: Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.|State Key Laboratory of Oncology in Southern China, Guangzhou, P. R. China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, P. R. China.
authors.forename: Jie-Ping
authors.initials: JP
authors.lastname: Chen
authors.affiliation: Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.|State Key Laboratory of Oncology in Southern China, Guangzhou, P. R. China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, P. R. China.
authors.forename: Chuang-Zhong
authors.initials: CZ
authors.lastname: Deng
authors.affiliation: Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.|State Key Laboratory of Oncology in Southern China, Guangzhou, P. R. China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, P. R. China.
authors.forename: Yun-Lin
authors.initials: YL
authors.lastname: Ye
authors.affiliation: Department of Urology, The People's Hospital of Jiangmen, Jiangmen, P. R. China.
authors.forename: Ming-Zhu
authors.initials: MZ
authors.lastname: Zhong
authors.affiliation: Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.|State Key Laboratory of Oncology in Southern China, Guangzhou, P. R. China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, P. R. China.
authors.forename: Zhuo-Wei
authors.initials: ZW
authors.lastname: Liu
authors.affiliation: Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.|State Key Laboratory of Oncology in Southern China, Guangzhou, P. R. China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, P. R. China.
authors.forename: Zi-Ke
authors.initials: ZK
authors.lastname: Qin
authors.affiliation: Zhongshan School of Medicine, Sun Yat-sen University, Guang Dong, P. R. China.
authors.forename: Xiang-Tian
authors.initials: XT
authors.lastname: Lin
authors.affiliation: Zhongshan School of Medicine, Sun Yat-sen University, Guang Dong, P. R. China.
authors.forename: Wei-Cong
authors.initials: WC
authors.lastname: Liang
authors.affiliation: Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.|State Key Laboratory of Oncology in Southern China, Guangzhou, P. R. China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Han
authors.affiliation: Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.|State Key Laboratory of Oncology in Southern China, Guangzhou, P. R. China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, P. R. China.
authors.forename: Fang-Jian
authors.initials: FJ
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000556:secondary*; D002681:China; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010412:Penile Neoplasms / Q000378:metabolism / Q000473:pathology*; D011300:Preoperative Care; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D002097:C-Reactive Protein
keywords: C-reactive protein; body mass index; neoplasm staging; penile neoplasms; prognosis