title: Does the Presence of Endometriosis Affect Prognosis of Ovarian Cancer?
abstract: Ovarian cancers diagnosed between 2000 and 2013 were examined and cases with and without endometriosis compared. Among 139 epithelial ovarian, there were 49 (35%) with endometriosis and 90 (65%) without endometriosis. Endometriosis associated ovarian cancers were more likely to be confined to the pelvis (54% vs. 9%, p < 0.0001) and lower grade (51% vs. 29%, p = 0.014). Younger age and earlier stage independently predicted the presence of endometriosis (p = 0.0011 and p < 0.0001, respectively). Ovarian cancer patients with endometriosis had improved PFS and OS [(HR = 0.20; 95% CI, 0.09-0.43), (HR = 0.18; 95% CI, 0.04-0.81)], compared to patients without endometriosis; however, endometriosis had no independent prognostic significance.
authors.affiliation: a Division of Gynecologic Oncology, Weill Cornell Medical College , New York , NY , USA.
authors.forename: Helen E
authors.initials: HE
authors.lastname: Dinkelspiel
authors.affiliation: b Department of Pathology and Laboratory Medicine , Weill Cornell Medical College , New York , NY , USA.
authors.forename: Cathleen
authors.initials: C
authors.lastname: Matrai
authors.affiliation: c Weill Cornell Medical College , New York , NY , USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Pauk
authors.affiliation: c Weill Cornell Medical College , New York , NY , USA.
authors.forename: Alain
authors.initials: A
authors.lastname: Pierre-Louis
authors.affiliation: c Weill Cornell Medical College , New York , NY , USA.
authors.forename: Ya-Lin
authors.initials: YL
authors.lastname: Chiu
authors.affiliation: d Division of Gynecologic Oncology , New York , NY , USA.
authors.forename: Divya
authors.initials: D
authors.lastname: Gupta
authors.affiliation: d Division of Gynecologic Oncology , New York , NY , USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Caputo
authors.affiliation: b Department of Pathology and Laboratory Medicine , Weill Cornell Medical College , New York , NY , USA.
authors.forename: Lora Hedrick
authors.initials: LH
authors.lastname: Ellenson
authors.affiliation: d Division of Gynecologic Oncology , New York , NY , USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Holcomb
mesh_terms: D000368:Aged; D000077216:Carcinoma, Ovarian Epithelial; D018572:Disease-Free Survival; D004715:Endometriosis / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis* / Q000401:mortality; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000401:mortality; D011379:Prognosis; D016016:Proportional Hazards Models
keywords: Epidemiology; Outcomes research; Outreach; Ovarian cancer