title: Assessment of the association between Apgar scores and seizures in infants less than 1 year old.
abstract: OBJECTIVE
  The study aimed to assess the association between Apgar scores at 1 and 5 min after birth and seizures in infants less than 1 year old.
  
  
  METHODS
  We conducted a retrospective, observational, hospital-based study by utilising medical records from the Chung-Ang University Hospital admissions from January 2006 to May 2015 in order to identify infants less than 1 year old who had a history of seizures. Using electronic medical records, infants who were diagnosed with infantile seizures at the Chung-Ang University Hospital from January 2006 to May 2015 were included in the seizure group (n=93), and a control group consisting of 296 age-matched cases without a history of seizures was selected from a group of infants born at Chung-Ang University Hospital during the same study period.
  
  
  RESULTS
  We found that Apgar scores were significant risk factors for infantile seizures. Apgar scores differed depending on gestational age and birth weight. We found strong associations between Apgar scores and infantile seizures in the full-term and the normal-birth weight groups (bodyweight ≥2.5 kg), regardless of delivery mode. The Apgar scores were inversely correlated with the EEG class, and only the 1-min Apgar scores were correlated with MRI findings.
  
  
  CONCLUSIONS
  Low Apgar scores are significant perinatal risk factors for infantile seizures, especially in full-term and normal-birth weight infants, and have a strong negative linear relationship with EEG and brain MRI results in the seizure group.
authors.affiliation: Department of Pediatrics, College of Medicine, Chung-Ang University, 224-1 Heukseok-dong Dongjak-gu, Seoul 156-755, Republic of Korea.
authors.forename: Seonghoon
authors.initials: S
authors.lastname: Eun
authors.affiliation: Department of Pediatrics, College of Medicine, Chung-Ang University, 224-1 Heukseok-dong Dongjak-gu, Seoul 156-755, Republic of Korea.
authors.forename: Jeong Min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, College of Medicine, Chung-Ang University, 224-1 Heukseok-dong Dongjak-gu, Seoul 156-755, Republic of Korea.
authors.forename: Dae Yong
authors.initials: DY
authors.lastname: Yi
authors.affiliation: Department of Pediatrics, College of Medicine, Chung-Ang University, 224-1 Heukseok-dong Dongjak-gu, Seoul 156-755, Republic of Korea.
authors.forename: Na Mi
authors.initials: NM
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, College of Medicine, Chung-Ang University, 224-1 Heukseok-dong Dongjak-gu, Seoul 156-755, Republic of Korea.
authors.forename: Hyery
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, College of Medicine, Chung-Ang University, 224-1 Heukseok-dong Dongjak-gu, Seoul 156-755, Republic of Korea.
authors.forename: Sin Weon
authors.initials: SW
authors.lastname: Yun
authors.affiliation: Department of Pediatrics, College of Medicine, Chung-Ang University, 224-1 Heukseok-dong Dongjak-gu, Seoul 156-755, Republic of Korea.
authors.forename: InSeok
authors.initials: I
authors.lastname: Lim
authors.affiliation: Department of Pediatrics, College of Medicine, Chung-Ang University, 224-1 Heukseok-dong Dongjak-gu, Seoul 156-755, Republic of Korea.
authors.forename: Eung Sang
authors.initials: ES
authors.lastname: Choi
authors.affiliation: Department of Pediatrics, College of Medicine, Chung-Ang University, 224-1 Heukseok-dong Dongjak-gu, Seoul 156-755, Republic of Korea. Electronic address: kidbrain@korea.com.
authors.forename: Soo Ahn
authors.initials: SA
authors.lastname: Chae
mesh_terms: D001034:Apgar Score; D001724:Birth Weight; D001921:Brain / Q000503:physiopathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D012640:Seizures / Q000175:diagnosis* / Q000503:physiopathology
keywords: Apgar score; Infantile seizure; Perinatal factor