title: The National Cancer Institute's PREVENT Cancer Preclinical Drug Development Program: overview, current projects, animal models, agent development strategies, and molecular targets.
abstract: The PREVENT Cancer Preclinical Drug Development Program (PREVENT) is a National Cancer Institute, Division of Cancer Prevention (NCI, DCP)-supported program whose primary goal is to bring new cancer preventive interventions (small molecules and vaccines) and biomarkers through preclinical development towards clinical trials by creating partnerships between the public sector (eg, academia, industry) and DCP. PREVENT has a formalized structure for moving interventions forward in the prevention pipeline using a stage-gate process with go/no go decision points along the critical path for development. This review describes the structure of the program, its focus areas, and provides examples of projects currently in the pipeline.
authors.affiliation: Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: Shoemakr@mail.nih.gov.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Shoemaker
authors.affiliation: Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Chen S
authors.initials: CS
authors.lastname: Suen
authors.affiliation: CCS Associates, Inc, Mountain View, CA, USA.
authors.forename: Cathy A
authors.initials: CA
authors.lastname: Holmes
authors.affiliation: CCS Associates, Inc, Mountain View, CA, USA.
authors.forename: Judith R
authors.initials: JR
authors.lastname: Fay
authors.affiliation: Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Vernon E
authors.initials: VE
authors.lastname: Steele
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents; D019496:Cancer Vaccines; D018890:Chemoprevention; D004195:Disease Models, Animal; D055808:Drug Discovery; D006078:Government Programs / Q000458:organization & administration*; D006801:Humans; D058990:Molecular Targeted Therapy; D054547:National Cancer Institute (U.S.); D009369:Neoplasms / Q000517:prevention & control*; D057170:Translational Research, Biomedical; D014481:United States
chemical_list: D016588:Anticarcinogenic Agents; D019496:Cancer Vaccines
keywords: Cancer; Chemoprevention; Immunoprevention; Preclinical support