title: Use of clobetasol in lacquer for plaque psoriasis treatment.
abstract: Clobetasol benefits to control psoriasis lesions are well defined, but there were not studies about its action when used in lacquer vehicle to control skin lesions. A double-blind study was conducted with 40 patients that utilized clobetasol 0.05% in one hemibody and just the vehicle in the other hemibody. Twenty of them used petrolatum as vehicle and the others used lacquer. An assessment was conducted using the clinical index PASI and a quality of life questionnaire (Dermatological Life Quality Index). There was no statistical difference between groups. There was a trend of favorable response particularly in the hemibody treated with clobetasol.
authors.affiliation: Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Suze Aparecida
authors.initials: SA
authors.lastname: da Silva
authors.affiliation: Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Renata Ferreira
authors.initials: RF
authors.lastname: Magalhães
authors.affiliation: Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Rafael Augusto Tamasauskas
authors.initials: RA
authors.lastname: Torres
authors.affiliation: Campinas, Campinas, SP, Brazil.
authors.forename: Raquel Diana
authors.initials: RD
authors.lastname: de Oliveira
authors.affiliation: Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Paulo Eduardo Neves Ferreira
authors.initials: PE
authors.lastname: Velho
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002990:Clobetasol / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007764:Lacquer; D008297:Male; D008875:Middle Aged; D014677:Pharmaceutical Vehicles; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy*; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D014677:Pharmaceutical Vehicles; D002990:Clobetasol