title: New cycloartane glycosides from the rhizomes of Cyperus rotundus and their antidepressant activity.
abstract: Two new cycloartane glycosides, cyprotusides A (1) and B (2), were isolated from the rhizomes of Cyperus rotundus. Their chemical structures were elucidated on the basis of IR, MS, NMR spectroscopic analyses coupled with chemical degradation. The potential antidepressant activity of the two compounds was evaluated. In the despair mice models, compounds 1 and 2 showed significant antidepressant activity.
authors.affiliation: a School of Chemistry and Chemical Engineering , Lingnan Normal University , Zhanjiang 524048 , China.
authors.forename: Zhong-Liu
authors.initials: ZL
authors.lastname: Zhou
authors.affiliation: a School of Chemistry and Chemical Engineering , Lingnan Normal University , Zhanjiang 524048 , China.
authors.forename: San-Qing
authors.initials: SQ
authors.lastname: Lin
authors.affiliation: b Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) , Ministry of Education of China , Guilin 541004 , China.
authors.forename: Wen-Qing
authors.initials: WQ
authors.lastname: Yin
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029786:Cyperus / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027343:Rhizome / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D014315:Triterpenes; C000613295:cyprotuside A; C000613296:cyprotuside B; C085352:cycloartane
keywords: Cyperus rotundus; antidepressant; cycloartane glycoside