title: Added value of MRI for the prenatal diagnosis of isolated orofacial clefts and comparison with ultrasound.
abstract: OBJECTIVE
  To evaluate the added value of fetal magnetic resonance imaging (MRI) in diagnosing and assessing isolated orofacial clefts and compare MRI with second-line diagnostic ultrasound.
  
  
  METHODS
  In a two-year prospective bicenter study, fetuses with isolated orofacial clefts were reassessed using second-line diagnostic ultrasound and MRI. The results of second line ultrasound and those MRI were compared to each other. The gestational age at the time of ultrasound and MRI, and the final diagnosis for each of the imaging modalities were recorded. Finally, the results of second line ultrasound and those of MRI were compared to the results of neonatal clinical examination after delivery that served as standard of reference.
  
  
  RESULTS
  Twenty-two women were included after informed consent was obtained. On average, diagnostic ultrasound was performed at 25.5weeks of gestation (range: 24-34weeks) and MRI at 29.5weeks of gestation (range: 27-34weeks). The results of ultrasound and those of MRI findings were strictly consistent in 20 women (20/22; 91%) but differed in 2 women (2/22; 9%). For all fetuses, the final radiological diagnosis was confirmed by clinical examination after delivery.
  
  
  CONCLUSIONS
  If ultrasound examination proves technically challenging, fetal MRI can be used to obtain the same diagnostic information in 91% of cases and can help surgeons and interdisciplinary teams provide appropriate antenatal counseling.
authors.affiliation: Service d'imagerie pédiatrique et prénatale, hôpital de La Timone-Enfants, AP-HM, 264, rue Saint-Pierre, 13385 Marseille, France. Electronic address: alexia.dabadie@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Dabadie
authors.affiliation: Institut méditerranéen de la reproduction, 6, rue Rocca, 13008 Marseille, France; Unité d'échographies obstétricales, fondation hôpital Saint-Joseph, 29, boulevard de Louvain, 13008 Marseille, France.
authors.forename: E
authors.initials: E
authors.lastname: Quarello
authors.affiliation: Service de chirurgie plastique pédiatrique, hôpital de La Timone-Enfants, AP-HM, 264, rue Saint-Pierre, 13385 Marseille, France.
authors.forename: N
authors.initials: N
authors.lastname: Degardin
authors.affiliation: Unité d'échographies obstétricales, fondation hôpital Saint-Joseph, 29, boulevard de Louvain, 13008 Marseille, France.
authors.forename: R
authors.initials: R
authors.lastname: Desbriere
authors.affiliation: Centre pluridisciplinaire de diagnostic prénatal, hôpital de La Timone-Enfants, AP-HM, 264, rue Saint-Pierre, 13385 Marseille, France.
authors.forename: H
authors.initials: H
authors.lastname: Heckenroth
authors.affiliation: Centre pluridisciplinaire de diagnostic prénatal, hôpital de La Timone-Enfants, AP-HM, 264, rue Saint-Pierre, 13385 Marseille, France.
authors.forename: S
authors.initials: S
authors.lastname: Sigaudy
authors.affiliation: Service d'imagerie pédiatrique et prénatale, hôpital de La Timone-Enfants, AP-HM, 264, rue Saint-Pierre, 13385 Marseille, France; Centre pluridisciplinaire de diagnostic prénatal, hôpital de La Timone-Enfants, AP-HM, 264, rue Saint-Pierre, 13385 Marseille, France.
authors.forename: G
authors.initials: G
authors.lastname: Gorincour
mesh_terms: D002971:Cleft Lip / Q000000981:diagnostic imaging*; D002972:Cleft Palate / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D064847:Multimodal Imaging; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal
keywords: Cleft lip/palate; Fetus; Magnetic resonance imaging; Prenatal diagnosis; Prenatal ultrasonography