title: Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines.
abstract: Histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, is a disease of protean manifestations and of global distribution. Although increasingly reported in Asia, there are few reports from the Philippines. Here, we describe a case of microbiologically diagnosed histoplasmosis, probably acquired from the Philippines, in a returning traveler who presented with a right foot wound and papular rash. The final diagnosis was disseminated histoplasmosis with cutaneous and bone involvement, both unusual manifestations of the disease.
authors.affiliation: Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Marwan M
authors.initials: MM
authors.lastname: Azar
authors.affiliation: Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut. Department of Surgery (Transplant), Yale School of Medicine, New Haven, Connecticut. maricar.malinis@yale.edu.
authors.forename: Maricar F
authors.initials: MF
authors.lastname: Malinis
mesh_terms: D061605:Administration, Intravenous; D000284:Administration, Oral; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000077723:Cefepime; D002511:Cephalosporins / Q000627:therapeutic use; D003907:Dexamethasone; D005500:Follow-Up Studies; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D008279:Magnetic Resonance Imaging; D008297:Male; D010019:Osteomyelitis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000382:microbiology; D010679:Philippines; D012871:Skin Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000382:microbiology; D013792:Thalidomide / Q000627:therapeutic use; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D002511:Cephalosporins; C068538:liposomal amphotericin B; D013792:Thalidomide; D014640:Vancomycin; D003907:Dexamethasone; D000666:Amphotericin B; D000077723:Cefepime