title: Validity of PROMIS physical function measured in diverse clinical samples.
abstract: To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function measures using longitudinal data collected in six chronic health conditions.
  
  
  
  Individuals with rheumatoid arthritis (RA), major depressive disorder (MDD), back pain, chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF), and cancer completed the PROMIS Physical Function computerized adaptive test or fixed-length short form at baseline and at the end of clinically relevant follow-up intervals. Anchor items were also administered to assess change in physical function and general health. Linear mixed-effects models and standardized response means were estimated at baseline and follow-up.
  
  
  
  A total of 1,415 individuals participated (COPD n = 121; CHF n = 57; back pain n = 218; MDD n = 196; RA n = 521; cancer n = 302). The PROMIS Physical Function scores improved significantly for treatment of CHF and back pain patients but not for patients with MDD or COPD. Most of the patient subsamples that reported improvement or worsening on the anchors showed a corresponding positive or negative change in PROMIS Physical Function.
  
  
  
  This study provides evidence that the PROMIS Physical Function measures are sensitive to change in intervention studies where physical function is expected to change and able to distinguish among different clinical samples. The results inform the estimation of meaningful change, enabling comparative effectiveness research.
authors.affiliation: Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: b-schalet@northwestern.edu.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Schalet
authors.affiliation: Department of Medicine, Division of General Internal Medicine and Health Services Research, UCLA, Los Angeles, CA 90095-1736, USA.
authors.forename: Ron D
authors.initials: RD
authors.lastname: Hays
authors.affiliation: Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Sally E
authors.initials: SE
authors.lastname: Jensen
authors.affiliation: Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Beaumont
authors.affiliation: Department of Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
authors.forename: James F
authors.initials: JF
authors.lastname: Fries
authors.affiliation: Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: David
authors.initials: D
authors.lastname: Cella
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease / Q000453:epidemiology*; D015897:Comorbidity; D057186:Comparative Effectiveness Research; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009316:National Institutes of Health (U.S.); D011594:Psychometrics; D015203:Reproducibility of Results; D057566:Self Report; D011795:Surveys and Questionnaires / Q000592:standards*; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: Chronic conditions; Item bank; PROMIS; Patient-reported outcome; Physical function; Validity