title: Asymmetric α-amination of β-keto esters using a guanidine-bisurea bifunctional organocatalyst.
abstract: An asymmetric α-amination of β-keto esters with azodicarboxylate in the presence of a guanidine-bisurea bifunctional organocatalyst was investigated. The α-amination products were obtained in up to 99% yield with up to 94% ee.
authors.affiliation: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei city, 184-8588, Tokyo, Japan.
authors.forename: Minami
authors.initials: M
authors.lastname: Odagi
authors.affiliation: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei city, 184-8588, Tokyo, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei city, 184-8588, Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagasawa
keywords: bifunctional catalyst; guanidine; hydrogen-bonding catalyst; urea; α-amination