title: A New Cytotoxic Clerodane Diterpene from Casearia graveolens Twigs.
abstract: The first phytochemical investigation of Casearia graveolens twigs led to the isolation and identification of a new clerodane diterpene, caseariagraveolin (1), together with six known compounds (2-7). Their structures were elucidated by intensive analysis of their spectroscopic data. Compound 1 showed strong cytotoxicity against oral cavity and breast cancer cell lines with IC₅₀ values of 2.48 and 6.63 µM, respectively.
authors.forename: Pornphimol
authors.initials: P
authors.lastname: Meesakul
authors.forename: Thunwadee
authors.initials: T
authors.lastname: Ritthiwigrom
authors.forename: Sarot
authors.initials: S
authors.lastname: Cheenpracha
authors.forename: Tawanun
authors.initials: T
authors.lastname: Sripisut
authors.forename: Wisanu
authors.initials: W
authors.lastname: Maneerat
authors.forename: Theeraphan
authors.initials: T
authors.lastname: Machan
authors.forename: Surat
authors.initials: S
authors.lastname: Laphookhieo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D037821:Casearia / Q000737:chemistry*; D045744:Cell Line, Tumor; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; C000606841:caseariagraveolin