title: Cutaneous Adenomyoepithelioma: Report of a Case and Review of the Literature.
abstract: Adenomyoepithelioma (AME) is a biphasic neoplasm of epithelial and myoepithelial cells. It is most commonly found in the breast, although rare cases have been reported from the lung, salivary glands, and skin. There are 5 well-documented cases of cutaneous AME in the literature. We report a new case of cutaneous AME. Our case was commingled with apocrine hidrocystoma. This is the first report of cutaneous AME in a male patient and the first to describe SOX10 immunostaining in cutaneous AME. We review the literature on cutaneous AME and note the greater than chance colocalization with other adnexal tumors. We speculate that AME may represent localized overgrowth of myoepithelial cells within a pre-existent sweat gland tumor. Histopathologists should be aware of the potential of SOX10-positive myoepithelial neoplasms to mimic nodular melanocytic proliferations.
authors.affiliation: *Contreras-Robledo Surgical Pathology Laboratory, Santiago, Dominican Republic; †Department of Pathology, University of Kansas School of Medicine, Kansas City, KS; ‡Johnson County Dermatology, Olathe, KS; and §Department of Pathology, University of Kansas School of Medicine, Kansas University Medical Center, Kansas City, KS.
authors.forename: Iván
authors.initials: I
authors.lastname: González
authors.forename: Manuel Lora
authors.initials: ML
authors.lastname: Gonzalez
authors.forename: Jan-Marie
authors.initials: JM
authors.lastname: Kroh
authors.forename: Garth R
authors.initials: GR
authors.lastname: Fraga
mesh_terms: D055331:Adenomyoepithelioma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000369:Aged, 80 and over; D001050:Apocrine Glands / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005260:Female; D018251:Hidrocystoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018193:Neoplasms, Complex and Mixed / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D055757:SOXE Transcription Factors / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013544:Sweat Gland Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; C527923:SOX10 protein, human; D055757:SOXE Transcription Factors