title: Humoral hypercalcemia due to gastric carcinoma secreting parathyroid hormone-related protein during chemotherapy: a case report.
abstract: Humoral hypercalcemia due to a gastric carcinoma-secreting parathyroid hormone-related protein (PTHrP) is a rare disease associated with poor prognosis. A 61-year-old male with gastric cancer who had been receiving chemotherapy showed serum hypercalcemia and an elevated level of serum PTHrP with a suppressed intact parathyroid hormone level. Computed tomography revealed stable disease 4 weeks prior, and the laboratory examination revealed no adverse effects 2 weeks prior. The biopsy at the time of diagnosis was immunohistochemically positive for PTHrP later. Despite intensive care, the patient died of multiorgan failure on the 14th day after admission. In case of undifferentiated gastric cancer, the possibility of humoral hypercalcemia of malignancy caused by gastric cancer should be considered even when the patient is receiving chemotherapy.
authors.affiliation: Department of Internal Medicine, Hirosaki Municipal Hospital, Hirosaki, Japan. chikaran0601@yahoo.co.jp.|Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. chikaran0601@yahoo.co.jp.
authors.forename: Chikara
authors.initials: C
authors.lastname: Iino
authors.affiliation: Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Shimoyama
authors.affiliation: Department of Internal Medicine, Hirosaki Municipal Hospital, Hirosaki, Japan.|Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors.forename: Yui
authors.initials: Y
authors.lastname: Akemoto
authors.affiliation: Department of Internal Medicine, Hirosaki Municipal Hospital, Hirosaki, Japan.|Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors.forename: Takasato
authors.initials: T
authors.lastname: Igarashi
authors.affiliation: Department of Internal Medicine, Hirosaki Municipal Hospital, Hirosaki, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Aihara
authors.affiliation: Department of Internal Medicine, Hirosaki Municipal Hospital, Hirosaki, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ishii
authors.affiliation: Department of Internal Medicine, Hirosaki Municipal Hospital, Hirosaki, Japan.
authors.forename: Juichi
authors.initials: J
authors.lastname: Sakamoto
authors.affiliation: Department of Internal Medicine, Hirosaki Municipal Hospital, Hirosaki, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tono
authors.affiliation: Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Fukuda
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism*; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy* / Q000378:metabolism*; D017809:Fatal Outcome; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D044162:Parathyroid Hormone-Related Protein / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D044162:Parathyroid Hormone-Related Protein
keywords: Gastric cancer; Humoral hypercalcemia of malignancy (HHM); Parathyroid hormone-related protein (PTHrP)