title: Molecular epidemiology identifies HIV transmission networks associated with younger age and heterosexual exposure among Korean individuals.
abstract: To evaluate if HIV transmission networks could be elucidated from data collected in a short time frame, 131 HIV-1 pol sequences were analyzed which were generated from treatment-naïve Korean individuals who were sequentially identified over 1 year. A transmission linkage was inferred when there was a genetic distance <1.5% and a total of 16 clusters, involving 39/131 (29.8%), were identified. Younger age and heterosexual exposure were independently related with clustering in the inferred network, which demonstrated that molecular epidemiology with currently generated data (i.e., drug resistance genotypes) can be used to identify local transmission networks, even over a short timeframe. J. Med. Virol. 88:1832-1835, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Center for Infectious Diseases, National Medical Center, Seoul, Republic of Korea.|Department of Medicine, University of California San Diego, La Jolla, California.
authors.forename: Bum Sik
authors.initials: BS
authors.lastname: Chin
authors.affiliation: Department of Medicine, University of California San Diego, La Jolla, California.
authors.forename: Antoine
authors.initials: A
authors.lastname: Chaillon
authors.affiliation: Department of Medicine, University of California San Diego, La Jolla, California.
authors.forename: Sanjay R
authors.initials: SR
authors.lastname: Mehta
authors.affiliation: Department of Medicine, University of California San Diego, La Jolla, California.
authors.forename: Joel O
authors.initials: JO
authors.lastname: Wertheim
authors.affiliation: Center for Infectious Diseases, National Medical Center, Seoul, Republic of Korea.
authors.forename: Gayeon
authors.initials: G
authors.lastname: Kim
authors.affiliation: Center for Infectious Diseases, National Medical Center, Seoul, Republic of Korea.
authors.forename: Hyoung-Shik
authors.initials: HS
authors.lastname: Shin
authors.affiliation: Department of Medicine, University of California San Diego, La Jolla, California.|Veterans Affairs San Diego Healthcare System, San Diego, California.
authors.forename: Davey M
authors.initials: DM
authors.lastname: Smith
mesh_terms: D000328:Adult; D000367:Age Factors; D016000:Cluster Analysis; D024882:Drug Resistance, Viral; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000235:genetics*; D020010:Heterosexuality; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D056910:Republic of Korea / Q000453:epidemiology; D055815:Young Adult; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D012367:RNA, Viral; D054302:pol Gene Products, Human Immunodeficiency Virus
keywords: cluster analysis; human immunodeficiency virus; molecular epidemiology; phylogeny