title: Reductions in knee joint forces with weight loss are attenuated by gait adaptations in class III obesity.
abstract: A consensus exists that high knee joint forces are a precursor to knee osteoarthritis and weight loss reduces these forces. Because large weight loss also leads to increased step length and walking velocity, knee contact forces may be reduced less than predicted by the magnitude of weight loss. The purpose was to determine the effects of weight loss on knee muscle and joint loads during walking in Class III obese adults. We determined through motion capture, force platform measures and biomechanical modeling the effects of weight loss produced by gastric bypass surgery over one year on knee muscle and joint loads during walking at a standard, controlled velocity and at self-selected walking velocities. Weight loss equaling 412 N or 34% of initial body weight reduced maximum knee compressive force by 824 N or 67% of initial body weight when walking at the controlled velocity. These changes represent a 2:1 reduction in knee force relative to weight loss when walking velocity is constrained to the baseline value. However, behavioral adaptations including increased stride length and walking velocity in the self-selected velocity condition attenuated this effect by ∼50% leading to a 392 N or 32% initial body weight reduction in compressive force in the knee joint. Thus, unconstrained walking elicited approximately 1:1 ratio of reduction in knee force relative to weight loss and is more indicative of walking behavior than the standard velocity condition. In conclusion, massive weight loss produces dramatic reductions in knee forces during walking but when patients stride out and walk faster, these favorable reductions become substantially attenuated.
authors.affiliation: Department of Kinesiology, East Carolina University, Greenville, NC 27858, USA. Electronic address: devitap@ecu.edu.
authors.forename: Paul
authors.initials: P
authors.lastname: DeVita
authors.affiliation: Department of Kinesiology, East Carolina University, Greenville, NC 27858, USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: Rider
authors.affiliation: Center For Human Movement Sciences, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; The Netherlands and Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, United Kingdom.
authors.forename: Tibor
authors.initials: T
authors.lastname: Hortobágyi
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D001696:Biomechanical Phenomena; D001835:Body Weight; D005260:Female; D005684:Gait / Q000502:physiology*; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology* / Q000534:rehabilitation; D016138:Walking / Q000502:physiology*; D015431:Weight Loss
keywords: Bariatric surgery; Biomechanics; Knee joint; Obesity; Walking; Weight loss