title: Serum Osteoprotegerin Levels Related With Cardiovascular Risk Factors in Chronic Kidney Disease.
abstract: BACKGROUND
  To evaluate osteoprotegerin (OPG) levels in relation to cardiovascular (CV) risk factors in patients with chronic kidney disease (CKD) on different regimens of renal replacement therapy.
  
  
  METHODS
  A total of 143 patients with CKD and 30 healthy controls were included in this study and divided into five categories, including predialysis patients with chronic renal failure (preD; n = 36), chronic peritoneal dialysis patients (PD; n = 36), hemodialysis patients (HD; n = 35), renal transplant patients (RT; n = 36), and controls (n = 30). Data on demographics, concomitant diseases and CV risk factors, serum OPG levels, and correlates of serum OPG levels were determined.
  
  
  RESULTS
  Serum OPG (pmol/l) levels were significantly higher in HD (P <0.001 for each), PD (P <0.001 for each), and preD (P <0.01 vs. control, P <0.05 vs. RT) groups than RT and control groups. Diabetics than nondiabetics in HD (P = 0.008), PD (P = 0.024), and RT (P = 0.004) groups and males than females in PD group (P = 0.021) had higher OPG levels. Serum OPG levels were associated positively with age in HD (P <0.001), PD (P = 0.001), and in overall population (P <0.001).
  
  
  CONCLUSIONS
  Our findings revealed increased serum levels of OPG in dialysis and preD patients compared to RT and controls. In the patient groups receiving two dialysis treatment, the levels were worse, indicating a more pronounced vascular injury. Age, C-reactive protein (CRP), high-density lipoprotein cholesterol (HDL-C), and cystatin C (CysC) in CKD patients, CRP and PTH in the control subjects, and age and BMI in the overall population were the significant correlates of serum OPG levels.
authors.affiliation: Department of Internal Medicine, Ministry of Health Okmeydani Research and Training Hospital, Istanbul, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Demir
authors.affiliation: Department of Internal Medicine, Ministry of Health Istanbul Research and Training Hospital, Istanbul, Turkey. fusunozerdenen@hotmail.com.
authors.forename: Fusun
authors.initials: F
authors.lastname: Erdenen
authors.affiliation: Department of Medical Biochemistry, Ministry of Health Istanbul Research and Training Hospital, Istanbul, Turkey.
authors.forename: Hale
authors.initials: H
authors.lastname: Aral
authors.affiliation: Department of Internal Medicine, Ministry of Health Istanbul Research and Training Hospital, Istanbul, Turkey.
authors.forename: Turker
authors.initials: T
authors.lastname: Emre
authors.affiliation: Department of Internal Medicine, Ministry of Health Istanbul Research and Training Hospital, Istanbul, Turkey.
authors.forename: Sennur
authors.initials: S
authors.lastname: Kose
authors.affiliation: Department of Internal Medicine, Ministry of Health Istanbul Research and Training Hospital, Istanbul, Turkey.
authors.forename: Esma
authors.initials: E
authors.lastname: Altunoglu
authors.affiliation: Department of Biostatistics, Medical Faculty, Hacettepe University, Ankara, Turkey.
authors.forename: Anil
authors.initials: A
authors.lastname: Dolgun
authors.affiliation: Department of Medical Biochemistry, Ministry of Health Istanbul Research and Training Hospital, Istanbul, Turkey.
authors.forename: Berrin Bercik
authors.initials: BB
authors.lastname: Inal
authors.affiliation: Department of Nephrology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Turkmen
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D055316:Cystatin C / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D006435:Renal Dialysis / Q000379:methods; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000453:epidemiology* / Q000628:therapy; D012307:Risk Factors
chemical_list: D055316:Cystatin C; D008075:Lipoproteins, HDL; D053244:Osteoprotegerin; D002097:C-Reactive Protein
keywords: cardiovascular risk; chronic kidney disease; osteoprotegerin; renal replacement therapy