title: New Anti-HBV C-Boivinopyranosyl Flavones from Alternanthera philoxeroides.
abstract: C-boivinopyranosyl flavones have rarely been isolated from nature. In the search for anti-HBV (hepatitis b virus) constituents of Alternanthera philoxeroides, two new compounds, luteolin-6-C-β-D-boivinopyranosyl-3'-O-β-D-glucopyranoside (1) and chrysoeriol-6-C-β-D-boivinopyranosyl-4'-O-β-D-glucopyranoside (2), along with three known C-boivinopyranosyl flavones (compounds 3-5) were isolated. Their structures were determined by spectroscopic analyses including 1D and 2D NMR, HR-ESI-MS, IR spectra. Compounds 1, 2 and 3 showed significant anti-HBV activities through specifically inhibiting the secretion of HBsAg in HepG2.2.15.
authors.affiliation: Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China. Jkylibin@hotmail.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. guonina@imm.ac.cn.
authors.forename: Qing-Lan
authors.initials: QL
authors.lastname: Guo
authors.affiliation: Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China. Hq6106@gmail.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China. lsj2518@sina.com.
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Liu
authors.affiliation: Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China. wqwangqiongwq@163.com.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China. hpch2003@gmail.com.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China. djx931314@163.com.
authors.forename: Jun-Xing
authors.initials: JX
authors.lastname: Dong
mesh_terms: D027703:Amaranthaceae / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology*; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D047309:Flavones; D010936:Plant Extracts
keywords: Alternanthera philoxeroides; C-boivinopyranosyl flavones; anti-HBV activity