title: Tributyltin disrupts feeding and energy metabolism in the goldfish (Carassius auratus).
abstract: Tributyltin (TBT) can induce obesogen response. However, little is known about the adverse effects of TBT on food intake and energy metabolism. The present study was designed to investigate the effects of TBT, at environmental concentrations of 2.44 and 24.4 ng/L (1 and 10 ng/L as Sn), on feeding and energy metabolism in goldfish (Carassius auratus). After exposure for 54 d, TBT increased the weight gain and food intake in fish. The patterns of brain neuropeptide genes expression were in line with potential orexigenic effects, with increased expression of neuropeptide Y and apelin, and decreased expression of pro-opiomelanocortin, ghrelin, cocaine and amphetamine-regulated transcript, and corticotropin-releasing factor. Interestingly, the energy metabolism indicators (oxygen consumption, ammonia exertion and swimming activity) and the serum thyroid hormones were all significantly increased at the 2.44 ng/L TBT group in fish. However, no changes of energy metabolism indicators or a decrease of thyroid hormones was found at the 24.4 ng/L TBT group, which indicated a complex disrupting effect on metabolism of TBT. In short, TBT can alter feeding and energy metabolism in fish, which might promote the obesogenic responses.
authors.affiliation: Henan Open Laboratory of Key Subjects of Environmental and Animal Products Safety, College of Animal Science and Technology, Henan University of Science and Technology, Henan, China. Electronic address: jiliang_zhang@126.com.
authors.forename: Jiliang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Henan Open Laboratory of Key Subjects of Environmental and Animal Products Safety, College of Animal Science and Technology, Henan University of Science and Technology, Henan, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Sun
authors.affiliation: Henan Open Laboratory of Key Subjects of Environmental and Animal Products Safety, College of Animal Science and Technology, Henan University of Science and Technology, Henan, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Henan Open Laboratory of Key Subjects of Environmental and Animal Products Safety, College of Animal Science and Technology, Henan University of Science and Technology, Henan, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Kong
authors.affiliation: Henan Open Laboratory of Key Subjects of Environmental and Animal Products Safety, College of Animal Science and Technology, Henan University of Science and Technology, Henan, China.
authors.forename: Ruichen
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004435:Eating / Q000187:drug effects* / Q000235:genetics; D004734:Energy Metabolism / Q000187:drug effects* / Q000235:genetics; D005247:Feeding Behavior / Q000187:drug effects*; D015870:Gene Expression / Q000187:drug effects; D006054:Goldfish / Q000235:genetics / Q000378:metabolism*; D009478:Neuropeptide Y / Q000235:genetics / Q000378:metabolism; D013550:Swimming; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D009478:Neuropeptide Y; D014220:Trialkyltin Compounds; D014874:Water Pollutants, Chemical; C011559:tributyltin
keywords: Food intake; Goldfish; Neuropeptide; Thyroid hormone; Tributyltin