title: Effects of Sesame Butter (Ardeh) versus Sesame Oil on Metabolic and Oxidative Stress Markers in Streptozotocin-Induced Diabetic Rats.
abstract: BACKGROUND
  Diabetes is one of the most common metabolic disorders and is related to oxidative-stress-induced diseases. Given the role of dietary antioxidants in the control and prevention of diabetes, this study aimed to examine the effects of sesame butter versus sesame oil on the serum levels of glucose, lipid profile, and oxidative stress biomarkers in diabetic rats.
  
  
  METHODS
  Forty male albino rats of Wistar strain were randomly divided into 4 groups (i.e., nondiabetic control rats, diabetic rats, diabetic rats treated with sesame butter, and diabetic rats treated with sesame oil). Experimental diabetes was induced with an intraperitoneal injection of streptozotocin (55 mg/kg). Sesame butter (1.25 g/kg) and sesame oil (0.5 g/kg) were given by oral gavage to the diabetic rats for 6 weeks. Finally, serum glucose, lipid profile, total antioxidant capacity (TAC), and malondialdehyde (MDA) levels were measured and analyzed statistically.
  
  
  RESULTS
  Our data showed that the diabetic groups treated with sesame butter and sesame oil had significantly lower levels of glucose and higher levels of high-density lipoprotein than did the diabetic control group at the end of the study (P<0.05). Sesame butter supplementation also increased TAC and decreased MDA concentrations significantly in the diabetic rats (P<0.05).
  
  
  CONCLUSIONS
  The antihyperglycemic, antioxidative, and partly lipid-lowering effects of sesame butter make it an excellent candidate for future human studies on diabetes, although further research is needed to determine the exact dose and duration of supplementation.
authors.affiliation: Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Haidari
authors.affiliation: Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Mohammadshahi
authors.affiliation: Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Zarei
authors.affiliation: Department of Nutritional Science, Arvand International Division of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Gorji
keywords: Antioxidants; Diabetes mellitus; Hyperglycemia; Lipids; Oxidative stress; Sesame oil