title: Cytokeratin 17 Expression is Associated With Poor Prognosis in Gallbladder Adenocarcinoma.
abstract: Cytokeratin 17 (CK17), a basal/myoepithelial cell keratin, is a poor prognostic marker for cancers of organs such as the stomach, ovary, and breast as well as a useful diagnostic marker for pancreatobiliary adenocarcinoma. However, its expression pattern and prognostic significance have not been studied in gallbladder adenocarcinoma. We constructed a tissue microarray from samples from 82 consecutive patients with gallbladder adenocarcinoma treated by cholecystectomy at the Kangbuk Samsung Hospital from 2000 to 2011. CK17 expression was examined by immunohistochemistry and correlated with clinicopathologic prognostic factors. CK17 stained the cytoplasm of tumor cells and immunohistochemical interpretation was possible in 77 cases. Among these, 41 (53.2%) were considered positive using a 5% cutoff determined by a receiver operating characteristic curve (area under the curve=0.656, P=0.021). CK17 expression was associated with poor tumor differentiation (P<0.001), high pT stage (P<0.001), presence of distant metastasis (P=0.036), and low disease-specific survival rate (P<0.001). These results indicate that CK17 can be used as a marker for poor prognosis for gallbladder adenocarcinoma.
authors.affiliation: Departments of *Pathology §Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul †Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon ‡Department of Pathology, Hallym University Sacred Heart Hospital, Anyang, South Korea.
authors.forename: Kyungeun
authors.initials: K
authors.lastname: Kim
authors.forename: Hyoun Wook
authors.initials: HW
authors.lastname: Lee
authors.forename: Seoung Wan
authors.initials: SW
authors.lastname: Chae
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Kim
authors.forename: In Gu
authors.initials: IG
authors.lastname: Do
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Sung-Im
authors.initials: SI
authors.lastname: Do
authors.forename: Kyueng-Whan
authors.initials: KW
authors.lastname: Min
authors.forename: Jung-Soo
authors.initials: JS
authors.lastname: Pyo
authors.forename: Jun-Ho
authors.initials: JH
authors.lastname: Shin
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Sohn
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D014408:Biomarkers, Tumor / Q000592:standards*; D005260:Female; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053537:Keratin-17 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D053537:Keratin-17