title: Effect of a thin superficial layer on the estimate of hemodynamic changes in a two-layer medium by time domain NIRS.
abstract: In order to study hemodynamic changes involved in muscular metabolism by means of time domain fNIRS, we need to discriminate in the measured signal contributions coming from different depths. Muscles are, in fact, typically located under other tissues, e.g. skin and fat. In this paper, we study the possibility to exploit a previously proposed method for analyzing time-resolved fNIRS measurements in a two-layer structure with a thin superficial layer. This method is based on the calculation of the time-dependent mean partial pathlengths. We validated it by simulating venous and arterial arm cuff occlusions and then applied it on in vivo measurements.
authors.affiliation: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Re
authors.affiliation: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Contini
authors.affiliation: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Zucchelli
authors.affiliation: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Torricelli
authors.affiliation: IFN-CNR, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Spinelli
keywords: (170.1470) Blood or tissue constituent monitoring; (170.2655) Functional monitoring and imaging; (170.5280) Photon migration; (170.6920) Time-resolved imaging