title: A meta-analysis of efficacy of Morus alba Linn. to improve blood glucose and lipid profile.
abstract: OBJECTIVE
  The previous studies have reported the Morus alba may improve blood glucose and lipid profile. The evidence from these studies is not consistent. This meta-analysis was to evaluate efficacy of products derived from M. alba on blood glucose and lipid levels.
  
  
  METHODS
  Literature was reviewed via international database (PubMed, PubMed Central, ScienceDirect, and SciSearch) and Thai databases. Thirteen RCTs with high quality, assessed by Jadad score, were included.
  
  
  RESULTS
  M. alba expressed a significant reduction in postprandial glucose (PPG) at 30 min (MD -1.04, 95 % CI -1.36, -0.73), 60 min (MD -0.87, 95 % CI -1.27, -0.48) and 90 min (MD -0.55, 95 % CI -0.87, -0.22). The difference was not found in the levels of other glycaemic (FBS, HbA1C, or HOMA-IR) and lipidaemic (TC, TG, LDL, or HDL) markers. Serious adverse effects were found neither in the control nor in the group received M. alba.
  
  
  CONCLUSIONS
  Products derived from M. alba can effectively contribute to the reduction in PPG levels, but large-scale RCTs would be informative.
authors.affiliation: Social Pharmacy Research Unit, Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham, 44150, Thailand. Wiraphol.p@msu.ac.th.
authors.forename: Wiraphol
authors.initials: W
authors.lastname: Phimarn
authors.affiliation: Social Pharmacy Research Unit, Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham, 44150, Thailand.
authors.forename: Kittisak
authors.initials: K
authors.lastname: Wichaiyo
authors.affiliation: Social Pharmacy Research Unit, Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham, 44150, Thailand.
authors.forename: Khuntawan
authors.initials: K
authors.lastname: Silpsavikul
authors.affiliation: Pharmaceutical Chemistry and Natural Products Research Unit, Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham, 44150, Thailand.
authors.forename: Bunleu
authors.initials: B
authors.lastname: Sungthong
authors.affiliation: Social Pharmacy Research Unit, Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham, 44150, Thailand.
authors.forename: Kritsanee
authors.initials: K
authors.lastname: Saramunee
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D031625:Morus / Q000737:chemistry*; D010936:Plant Extracts / Q000627:therapeutic use*; D019518:Postprandial Period; D016032:Randomized Controlled Trials as Topic; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D002784:Cholesterol; D006442:Glycated Hemoglobin; D010936:Plant Extracts; D014280:Triglycerides
keywords: Blood glucose; Blood lipid; Diabetes mellitus; Dyslipidaemia; Mulberry (Morus alba)