title: The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies.
abstract: Dishevelled (Dsh) is a key component of Wnt-signaling pathways and possibly also has other functional requirements. Dsh appears to be a key factor to interpret Wnt signals coming via the Wnt-receptor family, the Frizzled proteins, from the plasma membrane and route them into the correct intracellular pathways. However, how Dsh is regulated to relay signal flow to specific and distinct cellular responses upon interaction with the same Wnt-receptor family remains very poorly understood.
authors.affiliation: Department of Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: marek.mlodzik@mssm.edu.
authors.forename: Marek
authors.initials: M
authors.lastname: Mlodzik
mesh_terms: D000818:Animals; D003593:Cytoplasm / Q000378:metabolism*; D000072261:Dishevelled Proteins / Q000378:metabolism*; D004705:Endocytosis; D006801:Humans; D015398:Signal Transduction; D060449:Wnt Signaling Pathway
chemical_list: D000072261:Dishevelled Proteins
keywords: Dishevelled; Frizzled; Planar cell polarity; Signaling specificity; Wnt signaling