title: Influence of Target Parameters on Fixation Stability in Normal and Strabismic Monkeys.
abstract: OBJECTIVE
  The purpose of this study was to assess the effect of fixation target parameters on fixation instability in strabismic monkeys.
  
  
  METHODS
  One normal and three exotropic monkeys were presented with four differently shaped fixation targets, with three diameters, during monocular or binocular viewing. Fixation targets were white on a black background or vice versa. Binocular eye movements were recorded using the magnetic search coil technique and fixation stability quantified by calculating the bivariate contour ellipse area (BCEA).
  
  
  RESULTS
  Fixation instability was greater in all the strabismic monkeys compared with the normal monkey. During monocular viewing, strabismic monkeys showed significantly greater instability in the covered eye compared to the fixating eye. Multifactorial ANOVA suggested statistically significant target parameter influences, although effect sizes were small. Thus, a disk-shaped target resulted in greater instability than other target shapes in the viewing eyes of the normal monkey and two of three strabismic monkeys. A similar target-shape effect was also observed in the covered eye. Least instability was elicited with a 0.5° target in the normal monkey and a 1.0° target in the strabismic monkeys, both in the viewing and the covered eye. Target/background polarity effects were idiosyncratic. In strabismic monkeys, stability of the fixating eye during binocular viewing was not different from the stability of the same eye during monocular viewing.
  
  
  CONCLUSIONS
  Abnormal drifts and nystagmus contribute to increased fixation instability in strabismic monkeys. Target parameters (shape and size) that influence fixation stability in a normal animal also affected fixation stability in our sample of strabismic monkeys.
authors.forename: Onkar H
authors.initials: OH
authors.lastname: Pirdankar
authors.forename: Vallabh E
authors.initials: VE
authors.lastname: Das
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005133:Eye Movements / Q000502:physiology*; D005403:Fixation, Ocular / Q000502:physiology*; D008253:Macaca mulatta; D013285:Strabismus / Q000503:physiopathology*; D015348:Vision, Binocular / Q000502:physiology*; D015349:Vision, Monocular / Q000502:physiology; D014792:Visual Acuity