title: Correlations Between Abnormal Glucose Metabolism and Bone Mineral Density or Bone Metabolism.
abstract: BACKGROUND
  The aim of this meta-analysis was to explore the correlations of abnormal glucose metabolism (AGM) with bone mineral density (BMD) and bone metabolism.
  
  
  METHODS
  Relevant studies were identified using computerized and manual search strategies. The included studies were in strict accordance with inclusion and exclusion criteria. Statistical analyses were conducted with the Comprehensive Meta-analysis 2.0 (Biostat Inc., Englewood, NJ, USA).
  
  
  RESULTS
  Our present meta-analysis initially searched 844 studies, and 7 studies were eventually incorporated in the present meta-analysis. These 7 cohort studies included 1123 subjects altogether (560 patients with AGM and 563 healthy controls). The results showed that bone mass index (BMI), insulin, and insulin resistance (IR) of patients with AGM were significantly higher than that of the population with normal glucose metabolism (BMI: SMD=1.658, 95% CI=0.663~2.654, P=0.001; insulin: SMD=0.544, 95% CI=0.030~1.058, P=0.038; IR: SMD=8.767, 95% CI=4.178~13.356, P<0.001). However, the results also indicated there was no obvious difference in osteocalcin (OC) and BMD in patients with AGM and the population with normal glucose metabolism (OC: SMD=0.293, 95% CI=-0.023~0.609, P=0.069; BMD: SMD=0.805, 95% CI=-0. 212~1.821, P=0.121).
  
  
  CONCLUSIONS
  Our meta-analysis results suggest that AGM might lead to increased BMI, insulin, and IR, while it has no significant correlation with BMD or bone metabolism.
authors.affiliation: Department of Orthopedics, Second Hospital of Jilin University, Changchun, Jilin, China (mainland).
authors.forename: Yang
authors.initials: Y
authors.lastname: Qu
authors.affiliation: Department of Orthopedics, Second Hospital of Jilin University, Changchun, Jilin, China (mainland).
authors.forename: Ming-Yang
authors.initials: MY
authors.lastname: Kang
authors.affiliation: Department of Orthopedics, Second Hospital of Jilin University, Changchun, Jilin, China (mainland).
authors.forename: Rong-Peng
authors.initials: RP
authors.lastname: Dong
authors.affiliation: Department of Orthopedics, Second Hospital of Jilin University, Changchun, Jilin, China (mainland).
authors.forename: Jian-Wu
authors.initials: JW
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000378:metabolism; D017594:Publication Bias
chemical_list: D007328:Insulin; D015675:Osteocalcin; D005947:Glucose