title: FTH1P3, a Novel H-Ferritin Pseudogene Transcriptionally Active, Is Ubiquitously Expressed and Regulated during Cell Differentiation.
abstract: Ferritin, the major iron storage protein, performs its essential functions in the cytoplasm, nucleus and mitochondria. The variable assembly of 24 subunits of the Heavy (H) and Light (L) type composes the cytoplasmic molecule. In humans, two distinct genes code these subunits, both belonging to complex multigene families. Until now, one H gene has been identified with the coding sequence interrupted by three introns and more than 20 intronless copies widely dispersed on different chromosomes. Two of the intronless genes are actively transcribed in a tissue-specific manner. Herein, we report that FTH1P3, another intronless pseudogene, is transcribed. FTH1P3 transcript was detected in several cell lines and tissues, suggesting that its transcription is ubiquitary, as it happens for the parental ferritin H gene. Moreover, FTH1P3 expression is positively regulated during the cell differentiation process.
authors.affiliation: Research Center of Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Salvatore Venuta Campus, Catanzaro, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Di Sanzo
authors.affiliation: Research Center of Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Salvatore Venuta Campus, Catanzaro, Italy.
authors.forename: Ilenia
authors.initials: I
authors.lastname: Aversa
authors.affiliation: Research Center of Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Salvatore Venuta Campus, Catanzaro, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Santamaria
authors.affiliation: IBFM-CNR, c/o Università Magna Graecia, Catanzaro, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Gagliardi
authors.affiliation: Research Center of Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Salvatore Venuta Campus, Catanzaro, Italy.
authors.forename: Mariafranca
authors.initials: M
authors.lastname: Panebianco
authors.affiliation: Research Center of Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Salvatore Venuta Campus, Catanzaro, Italy.
authors.forename: Flavia
authors.initials: F
authors.lastname: Biamonte
authors.affiliation: Research Center of Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Salvatore Venuta Campus, Catanzaro, Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Zolea
authors.affiliation: Research Center of Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Salvatore Venuta Campus, Catanzaro, Italy.
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Faniello
authors.affiliation: Research Center of Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Salvatore Venuta Campus, Catanzaro, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cuda
authors.affiliation: Research Center of Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Salvatore Venuta Campus, Catanzaro, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Costanzo
mesh_terms: D001483:Base Sequence; D002454:Cell Differentiation; D002460:Cell Line; D005293:Ferritins / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D011544:Pseudogenes; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D005293:Ferritins