title: Sex-Related Differences Between Patients With Symptomatic Acute Aortic Dissection.
abstract: We designed a retrospective cohort study to assess sex-related differences in clinical manifestations, incidence, and outcomes of patients with symptomatic acute aortic dissection (AAD). We collected clinical data from 2010 to 2015 of 400 patients with AAD. Patients' clinical characteristics, treatment, and outcomes were analyzed as a function of sex. Among 400 patients with AAD, the ratio of men to women was 3.18:1; the incidence of atherosclerosis was higher in women (P = 0.02). Dysphoria (P = 0.01), focal neurological deficits (P = 0.04), and pulse deficits (P = 0.03) were more frequent in men. Imaging findings revealed that pleural effusion (P < 0.01), celiac trunk involvement (P < 0.01), and superior mesenteric artery involvement (P = 0.02) were more frequent in men. Dissection-related pneumonia (P = 0.02), pulmonary atelectasis (P = 0.01), aortic intramural hematoma (P < 0.01), ischemic electrocardiographic changes (P = 0.03), and in-hospital complications such as myocardial ischemia (P = 0.03), hypoxemia (P < 0.01), cardiac tamponade (P = 0.01) occurred more frequently in women. Women with type A dissection had higher in-hospital mortality than men (P < 0.01). The presentation of AAD varies with a patient's sex. Women with AAD had clinical features different from men as follows: higher age of onset, more frequent inpatient complications, and higher in-hospital mortality. These findings may lead to a better understanding of aortic dissection in women that will improve their outcomes.
authors.affiliation: From the Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, People's Republic of China (BM, Y-TM, MM, H-PS, XM, XX, AA, X-RZ, DX); Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, People's Republic of China (Y-TM, FL).
authors.forename: Buamina
authors.initials: B
authors.lastname: Maitusong
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Sun
authors.forename: Dilidaer
authors.initials: D
authors.lastname: Xielifu
authors.forename: Maisumu
authors.initials: M
authors.lastname: Mahemuti
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.forename: Adila
authors.initials: A
authors.lastname: Azhati
authors.forename: Xin-Rong
authors.initials: XR
authors.lastname: Zhou
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection / Q000150:complications / Q000401:mortality*; D001014:Aortic Aneurysm / Q000150:complications / Q000401:mortality*; D002681:China / Q000453:epidemiology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012727:Sex Characteristics; D055815:Young Adult