title: [Can preoperative prostate MRI before radical prostatectomy predict extracapsular extension and the side of the index lesion?].
abstract: OBJECTIVE
  To evaluate the role of preoperative multi-parametric magnetic resonance imaging (MP-MRI) in patients undergoing radical prostatectomy. Specifically, the accuracy of MP-MRI in detecting extracapsular extension (ECE) and individuating the side of the index lesion have been explored.
  
  
  METHODS
  Thirty-five consecutive patients undergoing radical prostatectomy have been retrospectively analyzed. The MRI exam incorporated T2-weighted imaging, diffusion-weighted imaging and dynamic contrast enhancement in all patients. χ(2) test was performed to assess an association between an MP-MRI suggestive of ECE and pathologic ECE; similar tests were performed to study the association between the MRI-detected side of the index lesion and its true localization on final pathology. Univariate logistic regression models were constructed to evaluate possible predictors of ECE, including MP-MRI suspected ECE.
  
  
  RESULTS
  Seventeen percent (6/35) of men presented ECE on final pathology. MP-MRI was predictive of pathologic ECE with a negative predictive value and specificity of 93% and 90%, respectively. Global accuracy of MP-MRI in predicting ECE was 86%. MRI-detected ECE was significantly predictive of pathologic ECE on logistic regression (OR: 17.3, 95% CI: 2.2-138.2, P=0.007). Moreover, MRI significantly predicted the side of the index lesion (P=0.012).
  
  
  CONCLUSIONS
  In this single center cohort, preoperative MP-MRI was significantly predictive of ECE and side of the index lesion. Further studies are necessary to individuate patients who can benefit from preoperative MP-MRI.
  
  
  METHODS
  5.
authors.affiliation: Département d'urologie, CHU Tivoli, université libre de Bruxelles, Bruxelles, Belgique; Département d'urologie, cliniques universitaires de Bruxelles, hôpital Erasme, université libre de Bruxelles, route de Lennik 808, 1070 Bruxelles, Belgique. Electronic address: albisinni.simone@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Albisinni
authors.affiliation: Département d'urologie, CHU Tivoli, université libre de Bruxelles, Bruxelles, Belgique.
authors.forename: A
authors.initials: A
authors.lastname: De Groote
authors.affiliation: Département d'urologie, CHU Tivoli, université libre de Bruxelles, Bruxelles, Belgique.
authors.forename: F
authors.initials: F
authors.lastname: Deneft
authors.affiliation: Département de radiologie, CHU Tivoli, université libre de Bruxelles, Bruxelles, Belgique.
authors.forename: P
authors.initials: P
authors.lastname: Thoma
authors.affiliation: Département d'anatomopathologie, CHU Tivoli, université libre de Bruxelles, Bruxelles, Belgique.
authors.forename: X
authors.initials: X
authors.lastname: Catteau
authors.affiliation: Département d'urologie, cliniques universitaires de Bruxelles, hôpital Erasme, université libre de Bruxelles, route de Lennik 808, 1070 Bruxelles, Belgique.
authors.forename: T
authors.initials: T
authors.lastname: Roumeguère
authors.affiliation: Département d'urologie, CHU Tivoli, université libre de Bruxelles, Bruxelles, Belgique.
authors.forename: T
authors.initials: T
authors.lastname: Wildschutz
mesh_terms: D000368:Aged; D001706:Biopsy; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D049451:Nomograms; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
keywords: Biopsies; Biopsy; Cancer de prostate; Extension extracapsulaire; Extracapsular extension; IRM; MRI; Prostate cancer; Prostatectomie radicale; Radical prostatectomy