title: Study of pathway cross-talk interactions with NF-κB leading to its activation via ubiquitination or phosphorylation: A brief review.
abstract: NFκB has been known to be a necessary transcription factor for the functioning of nearly all cells in a living organism. For its proper functioning, it talks to several other molecular cofactors and interacts with their functionalities resulting in a convoluted cross talking mesh of signalling networks. To completely understand the working of nuclear factor-kappa B protein, one needs to understand the interactions that occur during its lifecycle, with cofactors from various biological processes. This study attempts to elaborate and bridge the gaps on the cross-talk interactions that NFkB is a part of, during its activation pathway. For this Cytoscape and its various plugins (Cytocopter, Allegro, AgilentLitSearch and Styles) are employed. Other related pathways were also collated and analysed for cross-talk between NfκB and interacting molecules. NFκB was found to mainly interact with E3 ubiquitin ligase, NIK, RIP, TCR, IRAK-1, TLR, TRAF-6, NLR and IL-1, details of which are discussed as a part of this study.
authors.affiliation: Bioinformatics Division, School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India.
authors.forename: Sayantan
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Bioinformatics Division, School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India. Electronic address: mail2febin@gmail.com.
authors.forename: J Febin Prabhu
authors.initials: JFP
authors.lastname: Dass
mesh_terms: D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D054875:Ubiquitination
chemical_list: D016328:NF-kappa B
keywords: Alternate pathway; Canonical pathway; CellNOptR; Cytocopter; Cytoscape; E3 ubiquitin ligase complex; IKKß; IKKα; IRAK; IκB; MAP3K; Mal cascade; NEMO; NFκB; NIK; RIP; Signalling cross talk; TLR pathway; Ubiquitin proteasome signalling system