title: Extramedullary Involvement of Mast Cell Leukemia Detected by 18F-FDG PET/CT.
abstract: Mast cell leukemia (MCL) is a very rare subtype of systemic mastocytosis, characterized by the leukemic expansion of immature mast cells. We present a case of MCL with extramedullary involvement of cervical lymph node and lung demonstrated by the initial F-FDG PET/CT scan. After a transient complete remission by induction chemotherapy and allogeneic hematopoietic stem cell transplantation, the follow-up PET/CT showed extensive extramedullary relapse involving multiple lymph nodes and small bowel. F-FDG PET/CT may be a useful tool to comprehensively stage and follow-up MCL.
authors.affiliation: From the *Department of Nuclear Medicine, Peking University First Hospital; †Department of Nuclear Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China; and ‡Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: Zhanli
authors.initials: Z
authors.lastname: Fu
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Meng
authors.initials: M
authors.lastname: Liu
authors.forename: Ziao
authors.initials: Z
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
mesh_terms: D000293:Adolescent; D019788:Fluorodeoxyglucose F18; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007946:Leukemia, Mast-Cell / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D008297:Male; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography; D012008:Recurrence
chemical_list: D019788:Fluorodeoxyglucose F18