title: Recent advances in synthetic carbohydrate-based human immunodeficiency virus vaccines.
abstract: An effective vaccine for human immunodeficiency virus (HIV) is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome (AIDS). As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have attracted much attention. Significant efforts in carbohydrate synthesis and immunogenicity research have resulted in the development of multiple carbohydrate-based HIV vaccines. This review summarizes recent advances in synthetic carbohydrate-based vaccines design strategies and the applications of these vaccines in the prevention of HIV.
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
authors.forename: Zhenyuan
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
authors.forename: Chunjun
authors.initials: C
authors.lastname: Qin
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.|Wuxi Medical School, Jiangnan University, Wuxi, 214122, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Guo
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China. jianyin@jiangnan.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Yin
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000276:immunology*; D015195:Drug Design; D006023:Glycoproteins / Q000737:chemistry / Q000276:immunology; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D015497:HIV-1 / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D006801:Humans; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry; D022223:Vaccines, Subunit / Q000737:chemistry / Q000276:immunology; D014614:Vaccines, Synthetic / Q000737:chemistry* / Q000276:immunology*; D014758:Viral Core Proteins / Q000235:genetics / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D002241:Carbohydrates; D006023:Glycoproteins; D015483:HIV Antibodies; D009844:Oligosaccharides; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic; D014758:Viral Core Proteins
keywords: N-glycosylation; glycoprotein; human immunodeficiency virus (HIV); neutralizing antibodies; vaccine