title: The six-year outcome of alcohol use disorders in men: A population based study from India.
abstract: BACKGROUND
  Despite the large and growing public health problem of alcohol use disorders (AUD) in India there is a dearth of evidence about the longitudinal outcomes in AUD. The aim of this study is to describe the course and outcomes of AUD in a population based sample of men in India.
  
  
  METHODS
  A community cohort of 1899 adult (18-49 years at baseline) men who participated in a cross-sectional survey in Goa, India between 2006 and 08, were re-interviewed face to face 6 years later (2012-14). A range of outcomes including social problems (e.g., workplace problems, domestic violence), morbidity (e.g., range of physical and mental health problems), biological parameters (e.g., mean corpuscular volume [MCV], gamma-glutamyl transpeptidase [GGT]) and mortality were measured at follow up. For the association of AUD at baseline with outcomes at follow-up, multivariable logistic regression was used to estimate odds ratios (OR). Analyses were weighted to account for baseline sampling design, age distribution, rural and urban sample sizes, number of adults aged 18-49 years in the household (at baseline), and non-response (at baseline).
  
  
  RESULTS
  1514 (79.7%) were seen at follow-up; a loss to follow up of 20.3%. At follow up, 3.7% of baseline non-drinkers and 15.0% of baseline casual drinkers had AUD. 46.9% of baseline hazardous drinkers and 55.4% baseline harmful drinkers continued to have AUD at follow up. Of those with AUD at baseline, 21.8% had stopped drinking at follow-up. Compared to being abstinent, harmful drinking at baseline was associated with several outcomes at follow-up: workplace/social problems, hypertension, death, tobacco use, suicidality, anxiety disorders, and raised GGT (p<0.002). Hazardous drinking at baseline was associated with tobacco use and raised GGT and MCV (p<0.002) at follow-up.
  
  
  CONCLUSIONS
  Our findings of high persistent and new AUD in the community and the association with a range of long term adverse events are an important addition to the limited evidence about the course and outcomes of AUD in India, which have the potential for informing health policy.
authors.affiliation: Sangath, Goa, India; London School of Hygiene & Tropical Medicine, London, UK. Electronic address: abhijit.nadkarni@lshtm.ac.uk.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Nadkarni
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: Helen A
authors.initials: HA
authors.lastname: Weiss
authors.affiliation: Sangath, Goa, India.
authors.forename: Aresh
authors.initials: A
authors.lastname: Naik
authors.affiliation: Sangath, Goa, India.
authors.forename: Bhargav
authors.initials: B
authors.lastname: Bhat
authors.affiliation: Sangath, Goa, India; London School of Hygiene & Tropical Medicine, London, UK; Centre for Chronic Conditions and Injuries, Public Health Foundation of India, New Delhi, India.
authors.forename: Vikram
authors.initials: V
authors.lastname: Patel
mesh_terms: D000328:Adult; D000368:Aged; D019973:Alcohol-Related Disorders / Q000175:diagnosis* / Q000201:enzymology / Q000453:epidemiology* / Q000401:mortality; D015897:Comorbidity; D003430:Cross-Sectional Studies; D004909:Erythrocyte Indices / Q000187:drug effects; D005260:Female; D006304:Health Status; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012920:Social Behavior Disorders / Q000453:epidemiology*; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D005723:gamma-Glutamyltransferase
keywords: Alcohol use disorders; Cohort; India