title: The Challenge of Reproducibility and Accuracy in Nutrition Research: Resources and Pitfalls.
abstract: Inconsistent and contradictory results from nutrition studies conducted by different investigators continue to emerge, in part because of the inherent variability of natural products, as well as the unknown and therefore uncontrolled variables in study populations and experimental designs. Given these challenges inherent in nutrition research, it is critical for the progress of the field that researchers strive to minimize variability within studies and enhance comparability between studies by optimizing the characterization, control, and reporting of products, reagents, and model systems used, as well as the rigor and reporting of experimental designs, protocols, and data analysis. Here we describe some recent developments relevant to research on plant-derived products used in nutrition research, highlight some resources for optimizing the characterization and reporting of research using these products, and describe some of the pitfalls that may be avoided by adherence to these recommendations.
authors.affiliation: Office of Dietary Supplements and sorkinb@od.nih.gov.
authors.forename: Barbara C
authors.identifier: http://orcid.org/0000-0001-8198-6921
authors.initials: BC
authors.lastname: Sorkin
authors.affiliation: Office of Dietary Supplements and.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Kuszak
authors.affiliation: National Center for Complementary and Integrative Health, NIH, Bethesda, MD.
authors.forename: John S
authors.initials: JS
authors.lastname: Williamson
authors.affiliation: National Center for Complementary and Integrative Health, NIH, Bethesda, MD.
authors.forename: D Craig
authors.initials: DC
authors.lastname: Hopp
authors.affiliation: Office of Dietary Supplements and.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Betz
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry*; D035843:Biomedical Research / Q000379:methods* / Q000592:standards / Q000639:trends; D003226:Congresses as Topic; D000068598:Data Accuracy; D016208:Databases, Factual; D019587:Dietary Supplements / Q000032:analysis*; D005504:Food Analysis / Q000379:methods*; D006801:Humans; D000072667:National Center for Complementary and Integrative Health (U.S.); D052756:Nutritional Sciences / Q000379:methods* / Q000639:trends; D064209:Phytochemicals / Q000032:analysis*; D010945:Plants, Edible / Q000737:chemistry*; D015203:Reproducibility of Results
chemical_list: D001688:Biological Products; D064209:Phytochemicals
keywords: natural product integrity; orthogonal methods; phytochemical; quantitative analysis; reproducibility