title: Catanionic lipid nanosystems improve pharmacokinetics and anti-lung cancer activity of curcumin.
abstract: Novel catanionic lipid nanosystems (CLNs) incorporating curcumin (CCM) were developed, and improvements in pharmacokinetics and enhanced anti-lung cancer activity were observed. CCM was present in a lipid matrix surrounded by cationic, anionic and zwitterionic surfactants, forming the core-shell nanosystems. Compared with free CCM, the CCM-CLNs had much higher oral and intravenous bioavailabilities due to enhanced absorption and reduced clearance. The CCM-CLNs exhibited greater cytotoxicity in Lewis lung cancer (LLC) cells, which might have been due to increased antiproliferative, proapoptotic and anti-invasive activities and induction of cell cycle arrest. The CCM-CLNs increased the antitumor efficacy of CCM and decreased the tumor growth rate in tumor-bearing mice. This is the first report of induction of apoptosis in LLC cells by CCM through the PI3K/Akt/FoxO1/Bim signaling pathway. Catanionic lipid nanocarriers show promise for the therapeutic delivery of insoluble anti-tumor drugs.
authors.affiliation: Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Songlin
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Chunshu
authors.initials: C
authors.lastname: Fang
authors.affiliation: Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, China.
authors.forename: Jingqing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, China.
authors.forename: Bilin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Zhuanqin
authors.initials: Z
authors.lastname: Wei
authors.affiliation: Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Sui
authors.affiliation: Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China. Electronic address: tanqy001@163.com.
authors.forename: Qunyou
authors.initials: Q
authors.lastname: Tan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D017209:Apoptosis; D045744:Cell Line, Tumor; D003474:Curcumin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008055:Lipids / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000188:drug therapy*; D051379:Mice; D053758:Nanoparticles; D019869:Phosphatidylinositol 3-Kinases; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D008055:Lipids; D019869:Phosphatidylinositol 3-Kinases; D003474:Curcumin
keywords: Anti-lung cancer activity; Bioavailabilities; Catanionic lipid nanosystems; Curcumin; Signaling pathway