title: Detection of a novel X-chromosomal short tandem repeat marker in Xq28 in four ethnic groups.
abstract: DNA testing of X-chromosomal short tandem repeat (X-STR) polymorphisms has been the focus of attention in several studies, mainly due to its applicability in the investigation of complex kinship cases. Studies of X-STR in analyses of DNA sequences, population studies and DNA testing applications have been reported. We performed detection and population genetic study of a novel tetranucleotide X-STR locus in the present study. We identified a unique X-STR locus consisting of two tetranucleotides in Xq28. Although the STR is a simple tetranucleotide, its polymorphism was comparatively high [polymorphism information content (PIC)=0.7140] in Japanese subjects. In addition, the STR varied in structure among ethnic groups. We conclude that this locus will be useful for forensic DNA testing and anthropological studies.
authors.affiliation: Department of Forensic Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, 105-8461 Tokyo, Japan. Electronic address: mrpork24@jikei.ac.jp.
authors.forename: Takeki
authors.initials: T
authors.lastname: Nishi
authors.affiliation: Department of Legal Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Department of Legal Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Katuya
authors.initials: K
authors.lastname: Honda
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D041321:Chromosomes, Human, X; D003105:Colombia; D016172:DNA Fingerprinting / Q000379:methods*; D005260:Female; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D007564:Japan; D008297:Male; D018895:Microsatellite Repeats; D008986:Mongolia; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014481:United States; D044465:White People / Q000235:genetics*
keywords: Population; STR sequence; Short tandem repeat; X chromosome; X-STR