title: Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study.
abstract: BACKGROUND
  All findings of preeclampsia appear as the clinical consequences of diffuse endothelial dysfunction. Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) was recently introduced as a TNF related cytokine in various inflammatory and noninflammatory disorders. sTWEAK was found to be related to endothelial dysfunction in patients with chronic kidney disease. In our study we aimed to compare sTWEAK levels in women with preeclampsia to corresponding levels in a healthy pregnant control group.
  
  
  METHODS
  The study was undertaken with 33 patients with preeclampsia and 33 normal pregnant women. The concentration of sTWEAK in serum was calculated with an enzyme linked immunosorbent assay (ELISA) kit.
  
  
  RESULTS
  Serum creatinine, uric acid, LDH levels, and uPCR were significantly higher in the patient group compared to the control group. sTWEAK levels were significantly lower in preeclamptic patients (332 ± 144 pg/mL) than in control subjects (412 ± 166 pg/mL) (p = 0.04).
  
  
  CONCLUSIONS
  Our study demonstrates that sTWEAK is decreased in patients with preeclampsia compared to healthy pregnant women. There is a need for further studies to identify the role of sTWEAK in the pathogenesis of preeclampsia and to determine whether it can be regarded as a predictor of the development of preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Zeynep Kayaoglu
authors.initials: ZK
authors.lastname: Yildirim
authors.affiliation: Department of Nephrology, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Sumnu
authors.affiliation: Department of Obstetrics and Gynecology, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Bademler
authors.affiliation: Department of Biochemistry, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Kilic
authors.affiliation: Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Turkey.
authors.forename: Gulay
authors.initials: G
authors.lastname: Sumnu
authors.affiliation: Department of Nephrology, Haseki Training and Research Hospital, Istanbul, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Karadag
authors.affiliation: Department of Nephrology, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Gursu
authors.affiliation: Department of Obstetrics and Gynecology, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Ozel
authors.affiliation: Department of Obstetrics and Gynecology, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Gonca
authors.initials: G
authors.lastname: Batmaz
authors.affiliation: Department of Obstetrics and Gynecology, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Ates
authors.affiliation: Department of Obstetrics and Gynecology, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Dane
authors.affiliation: Department of Nephrology, Haseki Training and Research Hospital, Istanbul, Turkey.
authors.forename: Savas
authors.initials: S
authors.lastname: Ozturk
mesh_terms: D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D015415:Biomarkers / Q000097:blood*; D003401:Creatine / Q000097:blood; D000074049:Cytokine TWEAK; D015536:Down-Regulation; D005260:Female; D006801:Humans; D010865:Pilot Projects; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000378:metabolism*; D011247:Pregnancy; D048069:Tumor Necrosis Factors / Q000097:blood*; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D000074049:Cytokine TWEAK; C109743:TNFSF12 protein, human; D048069:Tumor Necrosis Factors; D014527:Uric Acid; D003401:Creatine