title: A novel capsular tension ring as local sustained-release carrier for preventing posterior capsule opacification.
abstract: One of the most important and challenging goals in pharmaceutical prevention for posterior capsule opacification is to preserve an effective drug concentration in capsular bag for a long period without affecting the patients' vision. Here, a novel kind of composite, which was prepared by 2-hydroxyethyl methacrylate (HEMA) and methyl methacrylate (MMA) via a two-step process, was applied for capsular tension ring (CTR) as an implant that could deliver docetaxel (DTX) over a long period of time. The drug release rate of the composite could be controlled by the ethyleneglycol dimethacrylate (EGDMA) content and the ratio of HEMA/MMA as well as the structure of porous PMMA framework. The CTR could continuously release DTX for up to 6 weeks in vitro and maintain DTX in effective concentration in the aqueous humor after 42 days. Docetaxel-load capsular tension ring (DTX-CTR) presented strong inhibition on the lens epithelial cells in-vivo without obvious damage to normal tissues. These results indicate that the drug sustained-release CTR can provide a promising application in posterior capsule opacification prevention.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Lei
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, China.
authors.forename: Zihang
authors.initials: Z
authors.lastname: Peng
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Dong
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, China.
authors.forename: Yuanfeng
authors.initials: Y
authors.lastname: He
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, China.
authors.forename: Zhaoguo
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, China.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, China.
authors.forename: Mina
authors.initials: M
authors.lastname: Yan
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, China. Electronic address: zhaocs@mail.sysu.edu.cn.
authors.forename: Chunshun
authors.initials: C
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D058442:Capsule Opacification / Q000473:pathology / Q000517:prevention & control*; D002460:Cell Line; D003692:Delayed-Action Preparations / Q000737:chemistry*; D000077143:Docetaxel; D006801:Humans; D008689:Methacrylates / Q000737:chemistry*; D008745:Methylation; D019736:Prostheses and Implants; D019919:Prosthesis Implantation; D011817:Rabbits; D043823:Taxoids / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D050257:Tubulin Modulators / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D008689:Methacrylates; D043823:Taxoids; D050257:Tubulin Modulators; D000077143:Docetaxel; C005044:hydroxyethyl methacrylate
keywords: Capsular tension ring; Docetaxel; High internal phase emulsion; Lens epithelial cells; Posterior capsule opacification