title: Probable Levofloxacin-associated Secondary Intracranial Hypertension in a Child With Multidrug-resistant Tuberculosis.
abstract: Fluoroquinolones are a key component of multidrug-resistant tuberculosis treatment. We describe the first reported case of probable levofloxacin-associated intracranial hypertension in a 6-year-old girl with pulmonary multidrug-resistant tuberculosis. The case highlights the potential risk of secondary intracranial hypertension in multidrug-resistant tuberculosis patients who require prolonged fluoroquinolone therapy and the need for ophthalmologic screening in children with suggestive signs and symptoms.
authors.affiliation: From the *Desmond Tutu TB Centre, Department of Pediatrics and Child Health, ‡Department of Pediatrics and Child Health, and §Department of Ophthalmology, Faculty of Medicine and Health Sciences, Stellenbosch University; and †Brooklyn Hospital for Chest Diseases, Cape Town, South Africa.
authors.forename: Louvina E
authors.initials: LE
authors.lastname: van der Laan
authors.forename: H Simon
authors.initials: HS
authors.lastname: Schaaf
authors.forename: Regan
authors.initials: R
authors.lastname: Solomons
authors.forename: Marianne
authors.initials: M
authors.lastname: Willemse
authors.forename: Nabil
authors.initials: N
authors.lastname: Mohamed
authors.forename: Sandika O
authors.initials: SO
authors.lastname: Baboolal
authors.forename: Anneke C
authors.initials: AC
authors.lastname: Hesseling
authors.forename: Ronald
authors.initials: R
authors.lastname: van Toorn
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Garcia-Prats
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000139:chemically induced* / Q000473:pathology*; D064704:Levofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin