title: Neuregulin/ErbB Signaling in Developmental Myelin Formation and Nerve Repair.
abstract: Myelin is essential for rapid and accurate conduction of electrical impulses by axons in the central and peripheral nervous system (PNS). Myelin is formed in the early postnatal period, and developmental myelination in the PNS depends on axonal signals provided by Nrg1/ErbB receptors. In addition, Nrg1 is required for effective nerve repair and remyelination in adulthood. We discuss here similarities and differences in Nrg1/ErbB functions in developmental myelination and remyelination after nerve injury.
authors.affiliation: Developmental Biology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany. Electronic address: cbirch@mdc-berlin.de.
authors.forename: Carmen
authors.initials: C
authors.lastname: Birchmeier
authors.affiliation: The Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. Electronic address: david.bennett@ndcn.ox.ac.uk.
authors.forename: David L H
authors.initials: DL
authors.lastname: Bennett
mesh_terms: D000818:Animals; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D009186:Myelin Sheath / Q000378:metabolism* / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D020890:Neuregulin-1 / Q000235:genetics / Q000378:metabolism*; D059348:Peripheral Nerve Injuries / Q000378:metabolism / Q000473:pathology; D014176:Protein Biosynthesis; D012583:Schwann Cells / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C094131:NRG1 protein, human; D020890:Neuregulin-1; D066246:ErbB Receptors
keywords: Myelination; Nrg1; Peripheral nervous system; Remyelination