title: I2-Catalyzed Multicomponent Reactions for Accessing Densely Functionalized Pyrazolo[1,5-a]pyrimidines and Their Disulphenylated Derivatives.
abstract: New I2-catalyzed multicomponent bicyclization reactions of β-ketonitriles with sulfonyl hydrazides have been established, providing a direct and metal-free access toward unreported pyrazolo[1,5-a]pyrimidin-4-ium sulfonates. The latter could be quantitatively converted into densely functionalized pyrazolo[1,5-a]pyrimidines in the presence of bases. Using sulfonyl hydrazides as a sulfenylating agent, the resulting pyrazolo[1,5-a]pyrimidines enabled I2-catalyzed unprecedented disulphenylations to access fully substituted pyrazolo[1,5-a]pyrimidines through direct C(sp(2))-H bond bifunctionalization.
authors.affiliation: College of Chemistry and Molecular Engineering, Biotechnology and Pharmaceutical Engineering, Nanjing Tech University , Nanjing 211816, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Sun
authors.affiliation: College of Chemistry and Molecular Engineering, Biotechnology and Pharmaceutical Engineering, Nanjing Tech University , Nanjing 211816, P. R. China.
authors.forename: Jiang-Kai
authors.initials: JK
authors.lastname: Qiu
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou 221116, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou 221116, P. R. China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Hao
authors.affiliation: College of Chemistry and Molecular Engineering, Biotechnology and Pharmaceutical Engineering, Nanjing Tech University , Nanjing 211816, P. R. China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Guo
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou 221116, P. R. China.
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu