title: Cyclosporine-induced sebaceous hyperplasia in a hematopoetic stem cell transplant patient: delayed onset of a common adverse event.
abstract: Cyclosporine-induced sebaceous hyperplasia (SH) is a well-documented entity, occurring in up to 30% of renal transplant patients treated with cyclosporine and has also been reported to occur following heart or hematopoetic stem cell transplantation (HCST). Cyclosporine has a stimulatory effect on undifferentiated sebocytes, resulting in the clinical and histologic findings in these patients. Sebaceous hyperplasia most commonly presents as asymptomatic papules over the face, chest, or groin. Herein we describe a case of a 27-year-old man who developed facial sebaceous hyperplasia five months after completing cyclosporine therapy for cutaneous graft versus host disease (GVHD) following HSCT.
authors.affiliation: University of California Davis Medical Center, Sacramento.
authors.forename: Reason
authors.initials: R
authors.lastname: Wilken
authors.forename: Maxwell A
authors.initials: MA
authors.lastname: Fung
authors.forename: Vivian Y
authors.initials: VY
authors.lastname: Shi
authors.forename: Michelle Y
authors.initials: MY
authors.lastname: Cheng
authors.forename: Forum
authors.initials: F
authors.lastname: Patel
authors.forename: Hawa
authors.initials: H
authors.lastname: Sultani
authors.forename: Emanual
authors.initials: E
authors.lastname: Maverakis
mesh_terms: D000328:Adult; D001706:Biopsy; D016572:Cyclosporine / Q000009:adverse effects*; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery*; D012625:Sebaceous Gland Diseases / Q000139:chemically induced* / Q000175:diagnosis; D012627:Sebaceous Glands / Q000187:drug effects / Q000473:pathology*; D033581:Stem Cell Transplantation / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine