title: Chemical constituents from Piper hainanense and their cytotoxicities.
abstract: Two new compounds, (Z,R)-1-phenylethylcinnamate (1) and (1R,2R,3R,6S)-pipoxide (2) were isolated from the aerial part of Piper hainanense, along with 12 known compounds, including nine benzene derivatives (4-11), one isobutylamide (12), and two polyoxygenated cyclohexene derivatives (13-14). Their structures were elucidated on the basis of the HRESIMS, 1D and 2D NMR spectroscopic analyses, and ECD in cases of 2 and 3. The absolute configuration of ellipeiopsol B (3) was determined for the first time. All these compounds 1-14 were reported from the titled plant for the first time. Most of the isolates were tested for their cytotoxicities against five human cancer cell lines. Four of which, 2, 3, 9, 14 showed moderate bioactivities. Among them, the new compound 2 showed potential cytotoxicity against SMMC-7721, MCF-7, and SW-480 with IC50 values of 9.7, 15.0, and 13.2 μM, respectively.
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.|b University of Chinese Academy of Sciences , Beijing , China.
authors.forename: Yan-Ni
authors.initials: YN
authors.lastname: Shi
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.|b University of Chinese Academy of Sciences , Beijing , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xin
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.|b University of Chinese Academy of Sciences , Beijing , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ling
authors.affiliation: c National Center for Natural Products Research, School of Pharmacy , University of Mississippi , Mississippi 38677 , USA.
authors.forename: Xing-Cong
authors.initials: XC
authors.lastname: Li
authors.affiliation: d Chinese Academy of Tropical Agricultural Sciences, Institute of Spice and Beverage Research , Hainan 100049 , China.
authors.forename: Chao-Yun
authors.initials: CY
authors.lastname: Hao
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Zhu
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Chong-Ren
authors.initials: CR
authors.lastname: Yang
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D053138:Cyclohexenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D031701:Piper / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry
chemical_list: C000613132:(1R,2R,3R,6S)-pipoxide; C000613131:(Z,R)-1-phenylethylcinnamate; D000972:Antineoplastic Agents, Phytogenic; D002934:Cinnamates; D053138:Cyclohexenes; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D014315:Triterpenes; C052568:cyclohexene
keywords: Piper hainanense; Piperaceae; benzene derivatives; cytotoxicity; pipoxide; polyoxygenated cyclohexene derivatives