title: Intra-axonal protein synthesis in development and beyond.
abstract: Proteins can be locally produced in the periphery of a cell, allowing a rapid and spatially precise response to the changes in its environment. This process is especially relevant in highly polarized and morphologically complex cells such as neurons. The study of local translation in axons has evolved from being primarily focused on developing axons, to the notion that also mature axons can produce proteins. Axonal translation has been implied in several physiological and pathological conditions, and in all cases it shares common molecular actors and pathways as well as regulatory mechanisms. Here, we review the main findings in these fields, and attempt to highlight shared principles.
authors.affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal; ICVS/3B's, PT Associate Laboratory, Braga/Guimarães, Portugal; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and Department for Pathology and Cell Biology, Columbia University, New York, NY, USA.
authors.forename: Andreia Filipa Rodrigues
authors.initials: AF
authors.lastname: Batista
authors.affiliation: The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and Department for Pathology and Cell Biology, Columbia University, New York, NY, USA. Electronic address: uh2112@cumc.columbia.edu.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hengst
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D012333:RNA, Messenger
keywords: Axon growth/branching; Axonal translation; Nerve injury; Neurodegeneration; Synapse formation; mRNA