title: Novel impact of EWI-2, CD9, and CD81 on TGF-β signaling in melanoma.
abstract: Cell surface transmembrane protein IGFS8 (herein called EWI-2) negatively regulates melanoma TGF-β signaling and is well positioned to control the transition in TGF-β signaling from cytostatic (in early melanoma stages) to pro-invasion/metastasis (in later stages). EWI-2 functions by sequestering the tetraspanin proteins CD9 and CD81, thereby making them unavailable to support the association of TGFβ receptor 1 with TGFβ receptor 2.
authors.affiliation: Department of Cancer Immunology and AIDS; Dana-Farber Cancer Institute and Department of Pathology; Harvard Medical School; Boston, MA USA.
authors.forename: Hong-Xing
authors.initials: HX
authors.lastname: Wang
authors.affiliation: Department of Cancer Immunology and AIDS; Dana-Farber Cancer Institute and Department of Pathology; Harvard Medical School; Boston, MA USA.
authors.forename: Martin E
authors.initials: ME
authors.lastname: Hemler
keywords: CD81; CD9; EWI-2/IGSF8; TGF-β1; melanoma; tetraspanins