title: Kainate-induced network activity in the anterior cingulate cortex.
abstract: Anterior cingulate cortex (ACC) plays a pivotal role in higher order processing of cognition, attention and emotion. The network oscillation is considered an essential means for integration of these CNS functions. The oscillation power and coherence among related areas are often dis-regulated in several psychiatric and pathological conditions with a hemispheric asymmetric manner. Here we describe the network-based activity of field potentials recorded from the superficial layer of the mouse ACC in vitro using submerged type recordings. A short activation by kainic acid administration to the preparation induced populational activities ranging over several frequency bands including theta (3-8Hz), alpha (8-12Hz), beta (13-30Hz), low gamma (30-50Hz) and high gamma (50-80Hz). These responses were repeatable and totally abolished by tetrodotoxin, and greatly diminished by inhibitors of ionotropic and metabotropic glutamate receptors, GABAA receptor or gap-junctions. These observations suggest that the kainate-induced network activity can be a useful model of the network oscillation in the ACC circuit.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Saitama Medical University, 38 Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Shinozaki
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Saitama Medical University, 38 Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hojo
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Saitama Medical University, 38 Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mukai
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Saitama Medical University, 38 Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hashizume
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Saitama Medical University, 38 Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan. Electronic address: t_mura@saitama-med.ac.jp.
authors.forename: T
authors.initials: T
authors.lastname: Murakoshi
mesh_terms: D000513:Alpha Rhythm / Q000187:drug effects; D000818:Animals; D001611:Beta Rhythm / Q000187:drug effects; D058256:Brain Waves / Q000187:drug effects*; D018690:Excitatory Amino Acid Agonists / Q000008:administration & dosage*; D065818:Gamma Rhythm / Q000187:drug effects; D017629:Gap Junctions / Q000502:physiology; D006179:Gyrus Cinguli / Q000187:drug effects* / Q000502:physiology*; D007608:Kainic Acid / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D011963:Receptors, GABA-A / Q000502:physiology; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology
chemical_list: D018690:Excitatory Amino Acid Agonists; D011963:Receptors, GABA-A; D018094:Receptors, Metabotropic Glutamate; D007608:Kainic Acid
keywords: anterior cingulate cortex; kainate; oscillation