title: Efficacy of zoledronic acid in Erdheim-Chester disease: A case report.
abstract: Erdheim-Chester disease is rare form of non-Langerhans cell histiocytosis characterized by organ infiltration of CD68+ CD1a- histiocytes. Between 500 and 600 cases have been reported. It is a multifaceted disease ranging from a solely asymptomatic bone to a fatal multisystem pattern. Bone involvement occurs in more than 90% of cases. Although not life-threatening, bone localizations can be responsible of difficult-to-treat pain and disability. Treatment depends on lesion severity. Bisphosphonates have been reported to be efficient and safe in bone involvement. We report a case of a biopsy proven bone Erdheim-Chester disease in a 65-year-old woman with history of breast cancer. Her pain was relieved after 3 perfusions of zoledronic acid and the efficiency remained at one year of follow-up.
authors.affiliation: Service de rhumatologie, pôle appareil locomoteur, centre Viggo-Petersen, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France. Electronic address: lucile.poiroux@gmail.com.
authors.forename: Lucile
authors.initials: L
authors.lastname: Poiroux
authors.affiliation: Service de médecine nucléaire, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Paycha
authors.affiliation: Service d'anatomie et de cytologie pathologique, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Polivka
authors.affiliation: Service de rhumatologie, pôle appareil locomoteur, centre Viggo-Petersen, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France; Faculté de médecine, université Paris Diderot, Paris 7, 10, avenue de Verdun, 75010 Paris, France. Electronic address: korngea@yahoo.fr.
authors.forename: Hang-Korng
authors.initials: HK
authors.lastname: Ea
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D001847:Bone Diseases / Q000188:drug therapy*; D001943:Breast Neoplasms / Q000150:complications / Q000628:therapy; D004164:Diphosphonates / Q000008:administration & dosage*; D031249:Erdheim-Chester Disease / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid
keywords: BRAF; Bisphosphonates; Bone; Erdheim-Chester; Histiocytosis