title: Insulin Resistance and β-cell Function Calculated by Homeostasis Model Assessment in Lean, Overweight, and Obese Women with Polycystic Ovary Syndrome.
abstract: OBJECTIVE
  To evaluate the homeostasis model assessment (HOMA) measurement of insulin resistance (IR) and pancreatic β-cell function (%β) and compare those values between groups of healthy-weight, over-weight, and obese women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Retrospective cohort study of women aged 24-48 with PCOS, diagnosed according to 2004 Rotterdam criteria. Participants were grouped by BMI. Quantitative variables were compared by one-way ANOVA and the Tukey method. Analysis for power to detect a difference between means was conducted. Pearson correlation was used to test differences in frequency distribution.
  
  
  RESULTS
  By BMI category, 29 participants were of healthy weight, 11 were overweight, and 11 were obese. HOMA-IR was significantly higher in obese women as compared to overweight and healthy-weight patients (2.88 ± 2.09, 1.13 ± 0.73, 0.84 ± 0.49, respectively; p <0.0001). Moreover, HOMA-%β was significantly increased in obese women as compared to overweight and healthy-weight patients (186.89 ± 131.62, 106.83 ± 46.77, 86.60 ± 40.91, respectively; p<0.0001). Adequate statistical power was not present to distinguish a difference between overweight and normal-weight participants. A positive linear correlation was found between log HOMA-IR and BMI, and between log HOMA-%β and BMI.
  
  
  CONCLUSIONS
  Obese PCOS patients have a higher risk of elevated insulin resistance and β-cell function than do those with BMI <30.
authors.forename: Ido
authors.initials: I
authors.lastname: Sirota
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Stein
authors.forename: Mario
authors.initials: M
authors.lastname: Vega
authors.forename: Martin D
authors.initials: MD
authors.lastname: Keltz
mesh_terms: D000328:Adult; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008875:Middle Aged; D008954:Models, Biological; D009765:Obesity / Q000150:complications / Q000503:physiopathology; D050177:Overweight / Q000150:complications / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000503:physiopathology; D055815:Young Adult