title: A gold(i)-catalyzed substituent-controlled cycloisomerization of propargyl vinyl ethers to multi-substituted furofuran and furopyran derivatives.
abstract: A gold(i)-catalyzed substituent-controlled strategy for the stereoselective synthesis of bicyclic furan and pyran derivatives has been developed. The mechanisms of the reactions have been studied thoroughly by deuterium labelling experiments. The applications of the methodologies were demonstrated by evaluating the preliminary anti-fungal activity of the synthetic compounds.
authors.affiliation: Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, P. R. China. yongxiang.liu@syphu.edu.cn mscheng@syphu.edu.cn.
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Liu
authors.forename: Shengfei
authors.initials: S
authors.lastname: Jin
authors.forename: Yanshi
authors.initials: Y
authors.lastname: Wang
authors.forename: Shanshan
authors.initials: S
authors.lastname: Cui
authors.forename: Xiaoshi
authors.initials: X
authors.lastname: Peng
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Niu
authors.forename: Chuan
authors.initials: C
authors.lastname: Du
authors.forename: Maosheng
authors.initials: M
authors.lastname: Cheng