title: Antihyperglycemic and antidiabetic effects of Ethyl (S)-2-(1-cyclohexylsulfamide carbamoyloxy) propanoate in streptozotocin-induced diabetic Wistar rats.
abstract: In this study, we examined the antihyperglycemic and antidiabetic effects of a novel synthesized molecule, the Ethyl (S)-2-(1-cyclohexylsulfamide carbamoyloxy) propanoate (ESP1b), in streptozotocin (STZ)-induced diabetic Wistar rats. Experimental diabetes mellitus was produced by a single intraperitoneal injection of STZ (55mg/kg b.w.). Seven day post-injection, animals have received ESP1b orally at the doses of 5, 10 and 20mg/kg b.w. daily for 28 days. This resulted in a clear decline, in a dose dependent manner, of blood glucose levels during the oral glucose tolerance test (OGTT) and the four weeks of treatment period. ESP1b at 20mg/kg b.w. has alleviated body weight loss, improved plasma insulin concentration and at the same time markedly decreased the values of glycosylated hemoglobin, lipoproteins and atherogenic ratios. Additionally, ESP1b notably restored renal as well as hepatic functions tests. Histopathological examinations of pancreatic tissue also confirmed the previous biochemical findings. Considering the obtained results, it may be concluded that ESP1b possess a potent antihyperglycemic activity in STZ-diabetic rats possibly related to an insulin-secretagogue effect, which may be responsible for the moderate decrease in blood glucose concentration observed in normal rats administrated with this tested compound.
authors.affiliation: Laboratory of Biochemistry and Applied Microbiology, Department of Biochemistry, Faculty of Sciences, Badji Mokhtar-Annaba University, P.O. Box 12, 23000 Annaba, Algeria; Department of Microbiology and Biochemistry, Faculty of Sciences, Mohamed Boudiaf-M'sila University, P.O. Box 166, Ichbelia, M'sila, Algeria. Electronic address: reggamiyassine@gmail.com.
authors.forename: Yassine
authors.initials: Y
authors.lastname: Réggami
authors.affiliation: Laboratory of Biochemistry and Applied Microbiology, Department of Biochemistry, Faculty of Sciences, Badji Mokhtar-Annaba University, P.O. Box 12, 23000 Annaba, Algeria.
authors.forename: Hajira
authors.initials: H
authors.lastname: Berredjem
authors.affiliation: Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Department of Chemistry, Badji Mokhtar-Annaba University, P.O. Box 12, 23000 Annaba, Algeria.
authors.forename: Hadjer
authors.initials: H
authors.lastname: Cheloufi
authors.affiliation: Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Department of Chemistry, Badji Mokhtar-Annaba University, P.O. Box 12, 23000 Annaba, Algeria.
authors.forename: Malika
authors.initials: M
authors.lastname: Berredjem
authors.affiliation: Laboratory of Biochemistry and Applied Microbiology, Department of Biochemistry, Faculty of Sciences, Badji Mokhtar-Annaba University, P.O. Box 12, 23000 Annaba, Algeria.
authors.forename: Noureddine
authors.initials: N
authors.lastname: Bouzerna
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000150:complications; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002219:Carbamates / Q000494:pharmacology* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005215:Fasting / Q000097:blood; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D011422:Propionates / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism; D013449:Sulfonamides / Q000494:pharmacology* / Q000627:therapeutic use; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D001663:Bilirubin; D001786:Blood Glucose; D002219:Carbamates; D003404:Creatinine; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D011422:Propionates; D012709:Serum Albumin; D013449:Sulfonamides; D014508:Urea; D014527:Uric Acid; C000613266:ethyl 2-(1-cyclohexylsulfamide carbamoyloxy)propanoate
keywords: Experimental diabetes; Insulin-secretagogue; Streptozotocin; Sulfonamide