title: Follicular lymphoma transforming into anaplastic diffuse large B-cell lymphoma of oral cavity: A case report with review of literature.
abstract: Follicular lymphoma (FL) is a common form of non-Hodgkin's lymphoma (NHL) with the ability to transform into a more aggressive disease, frequently to B cell-lymphoblastic lymphoma. Diffuse large B-cell lymphoma (DLBCL) is a subtype of NHL, which is characterized by diffuse proliferation of large neoplastic B-lymphocytes. It accounts for 30% of all NHL and its occurrence in the mandible is very rare. It is often seen in young adults, but in the present case, a 50-year-old male patient presented with painless swelling in left lower jaw since 25 days following extraction of left lower molar teeth. There was a history of fever and submandibular lymph nodes were enlarged. On incisional biopsy, features of NHL-like lesion were observed and confirmed by immunohistochemistry using CD20, bcl-2, CD10, CD3, CD5, Ki67 markers to be FL (3A) lymphoma transforming into DLBCL. This is a very uncommon presentation.
authors.affiliation: Department of Oral Pathology and Microbiology, Himachal Institute of Dental Sciences, Sirmour, Himachal Pradesh, India.
authors.forename: Megha
authors.initials: M
authors.lastname: Mittal
authors.affiliation: Department of Oral Pathology and Microbiology, Himachal Institute of Dental Sciences, Sirmour, Himachal Pradesh, India.
authors.forename: Abhiney
authors.initials: A
authors.lastname: Puri
authors.affiliation: Department of Oral Pathology and Microbiology, Himachal Institute of Dental Sciences, Sirmour, Himachal Pradesh, India.
authors.forename: Rajat
authors.initials: R
authors.lastname: Nangia
authors.affiliation: Department of Oral Pathology and Microbiology, Himachal Institute of Dental Sciences, Sirmour, Himachal Pradesh, India.
authors.forename: Alisha
authors.initials: A
authors.lastname: Sachdeva
keywords: Diffuse large B-cell lymphoma; follicular lymphoma; non-Hodgkin's lymphoma