title: Stereotactic body radiotherapy for patients with oligometastases from colorectal cancer: risk-adapted dose prescription with a maximum dose of 83-100 Gy in five fractions.
abstract: We previously reported that the local control of pulmonary metastases from colorectal cancer (CRC) following stereotactic body radiotherapy (SBRT) with moderate prescription dose was relatively worse. We investigated the treatment outcomes and toxicities of patients with oligometastases from CRC treated by SBRT using risk-adapted, very high- and convergent-dose regimens. Among patients referred for SBRT from August 2011 to January 2015, those patients were extracted who had liver or pulmonary metastases from CRC, and they were treated with a total dose of 50-60 Gy in five fractions prescribed to the 60% isodose line of the maximum dose covering the surface of the planning target volume. Concurrent administration of chemotherapy was not admitted during SBRT, while neoadjuvant or adjuvant chemotherapy was allowed. A total of 21 patients (12 liver, 9 lung) with 28 oligometastases were evaluated. The median follow-up duration was 27.5 months (range: 6.5-43.3 months). Four patients were treated with SBRT as a series of initial treatments, and 17 patients were treated after recurrent oligometastases. The local control rates at 1 and 2 years from the start of SBRT were 100%. The disease-free and actuarial overall survival rates were 62% and 55%, and 79% and 79%, respectively. No severe toxicities (≥grade 3) occurred during follow-up. The outcomes following high-dose SBRT were excellent. This treatment can provide an alternative to the surgical resection of oligometastases from CRC. Prospective studies are needed to validate the effectiveness of SBRT.
authors.affiliation: Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan takeda@1994.jukuin.keio.ac.jp.
authors.forename: Atsuya
authors.initials: A
authors.lastname: Takeda
authors.affiliation: Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Sanuki
authors.affiliation: Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Tsurugai
authors.affiliation: Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Oku
authors.affiliation: Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan.
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Aoki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000532:radiotherapy*; D016634:Radiosurgery / Q000009:adverse effects; D012307:Risk Factors; D016019:Survival Analysis