title: Cellular cannibalism in giant cells of central giant cell granuloma of jaw bones and giant cell tumors of long bones.
abstract: OBJECTIVE
  The aim of the present study was to investigate the relationship of central giant cell granuloma (CGCG) and giant cell tumor of long bones (GCT) with respect to cannibalistic giant cells (GCs).
  
  
  METHODS
  Sixteen cases each of CGCG and GCT were histopathologically analyzed for cannibalistic GCs. One hundred GCs were examined in each section, and the number of cannibalistic GCs was expressed in percentage.
  
  
  RESULTS
  Cannibalistic GCs were seen in all cases of CGCG and GCT (100%). GCT showed significantly higher mean cannibalistic GC frequency (44.81 ± 1.013) than CGCG (32.06 ± 1.398), aggressive CGCG (38.17 ± 1.579), non-aggressive CGCG (28.40 ± 0.6360), non-recurrent CGCG (30.42 ± 1.417), and recurrent CGCG (37.00 ± 2.483). In aggressive CGCG, the mean cannibalistic GC frequency was significantly higher (38.17 ± 1.579) than the non-aggressive variant (28.40 ± 0.6360). Recurrent CGCG cases showed significantly higher mean cannibalistic GC frequency (37.00 ± 2.483) than non-recurrent cases (30.42 ± 1.417). Similarly, recurrent GCT showed significantly higher mean cannibalistic GC frequency (47.4 ± 4.97) than non-recurrent GCT (43.63 ± 3.1).
  
  
  CONCLUSIONS
  The distinctness of CGCG and GCT was observed in terms of mean cannibalistic GC count. The assessment of cannibalistic GC in CGCG and GCT could help in predicting the biological behavior and grading of the tumor.
authors.affiliation: Department of Oral Pathology and Microbiology, Dr D. Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
authors.forename: Gargi S
authors.initials: GS
authors.lastname: Sarode
authors.affiliation: Department of Oral Pathology and Microbiology, Dr D. Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
authors.forename: Sachin C
authors.initials: SC
authors.lastname: Sarode
authors.affiliation: Department of Oral Pathology and Microbiology, Dr D. Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
authors.forename: Shailesh
authors.initials: S
authors.lastname: Gawande
authors.affiliation: Department of Oral Pathology and Microbiology, Dr D. Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
authors.forename: Snehal
authors.initials: S
authors.lastname: Patil
authors.affiliation: Department of Oral Pathology and Microbiology, Dr D. Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Anand
authors.affiliation: Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
authors.forename: Shankar Gouda
authors.initials: SG
authors.lastname: Patil
authors.affiliation: Department of Dentistry, Maharashtra Institute of Medical Education and Research, Pune, Maharashtra, India.
authors.forename: Prakash
authors.initials: P
authors.lastname: Patil
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005121:Extremities; D018212:Giant Cell Tumor of Bone / Q000473:pathology / Q000503:physiopathology*; D015726:Giant Cells / Q000502:physiology*; D006101:Granuloma, Giant Cell / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D010784:Photomicrography; D055815:Young Adult
keywords: cannibalistic giant cell; cellular cannibalism; central giant cell granuloma; giant cell; giant cell tumor