title: [Quality of life and socio-medical consequences in adolescent and young adult survivors following treatment for Hodgkin's lymphoma].
abstract: Between 1997 and 2008, 97 adolescents and young adults with a median age 18.9 years (range, 15.0-33.6) with all stages Hodgkin's lymphoma (HL) were treated by a pediatric protocol DAL-HD-90m. The 12-year event-free survival and overall survival was 73.4 ± 4.8% and 81.5 ± 4.7% respec- tively. The frequency of secondary malignancies was 2.1%. In the study of quality of life (QOL), 47 patients were included with duration of complete remission at least 5 years who had no relapses and other adverse events. The median age of the patients at the time of testing was 28.0 years (range, 23.2- 41.0). Reference values of age-adjusted 85 healthy volunteers were used for comparison. The QOL was measured through the questionnaire EORTC QLQ-C30. In total, the QOL of survivors was comparable to that of our control and reference values of EORTC. The only factor that influenced the QOL of long-term survivors was the presence or absence of their children. Among patients who did not have their own children was increased activity of the fatigue (+14.4 points; p = 0.035), insomnia (+25; p = 0.003) and anorexia (+16.7; p = 0.009). The deficit on the overall QOL score was -14.6 points (p = 0.005).
authors.forename: S Y
authors.initials: SY
authors.lastname: Semochkin
authors.forename: E G
authors.initials: EG
authors.lastname: Arshanskaya
authors.forename: V M
authors.initials: VM
authors.lastname: Sotnikov
authors.forename: A G
authors.initials: AG
authors.lastname: Rumyantsev
mesh_terms: D000293:Adolescent; D000328:Adult; D018572:Disease-Free Survival; D005221:Fatigue / Q000209:etiology; D005260:Female; D006304:Health Status; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000523:psychology / Q000628:therapy; D011788:Quality of Life; D012074:Remission Induction; D057566:Self Report; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications / Q000209:etiology; D016019:Survival Analysis; D017741:Survivors / Q000523:psychology / Q000706:statistics & numerical data; D055815:Young Adult