title: Therapeutic iron restriction in sepsis.
abstract: Sepsis represents the systemic immune response to an infection. Mortality of sepsis slightly decreased over the past years, but due to the growing incidence, the absolute number of deaths still increases and belongs to the three most frequent causes of death worldwide. To date, there is no specific treatment for sepsis available yet. Iron is essential to both human beings and microbes and of great significance in many physiological and biochemical processes. Since iron is involved in the bacterial proliferation and immune dysregulation, we hypothesize that restricting host iron levels by application of iron chelators attenuates bacterial growth and improves the detrimental dysregulation of the systemic immune response in sepsis.
authors.affiliation: School of Basic Medical Sciences, Zhejiang University, Zhejiang, China.
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Department of Pharmacology, Dalhousie University, Halifax, Canada.
authors.forename: Nizam
authors.initials: N
authors.lastname: Farah
authors.affiliation: Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada.
authors.forename: Alexander
authors.initials: A
authors.lastname: Maxan
authors.affiliation: Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada; Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Canada.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Pharmacology, Dalhousie University, Halifax, Canada; Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada; Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Canada; Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada.
authors.forename: Christian
authors.initials: C
authors.lastname: Lehmann
mesh_terms: D001419:Bacteria / Q000187:drug effects / Q000276:immunology*; D019317:Evidence-Based Medicine; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology*; D007501:Iron / Q000276:immunology*; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology* / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D007502:Iron Chelating Agents; D007501:Iron