title: Chiral NHC Ligands Bearing a Pyridine Moiety in Copper-Catalyzed 1,2-Addition of Dialkylzinc Reagents to β-Aryl-α,β-unsaturated N-Tosylaldimines.
abstract: Asymmetric 1,2-addition of dialkylzinc reagents to α,β-unsaturated N-tosylaldimines was catalyzed by copper salt in the presence of chiral imidazolium salts having a pyridine ring, which were derived from amino acid, to afford the corresponding chiral allylic amines with up to 91% ee in reasonably high yields. The chiral N-heterocyclic carbene (NHC) ligand played an important role in controlling chemoselectivity.
authors.affiliation: Division of Material Chemistry, Graduate School of Natural Science and Technology, Kanazawa University , Kakuma, Kanazawa 920-1192, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Soeta
authors.affiliation: Division of Material Chemistry, Graduate School of Natural Science and Technology, Kanazawa University , Kakuma, Kanazawa 920-1192, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ishizaka
authors.affiliation: Division of Material Chemistry, Graduate School of Natural Science and Technology, Kanazawa University , Kakuma, Kanazawa 920-1192, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ukaji