title: Evaluation of a fibrate, specific stimulant of PPARα, as a therapeutic alternative to the treatment of clinical ovine pregnancy toxaemia.
abstract: Ovine pregnancy toxaemia is a metabolic disorder affecting sheep in their last 6 weeks of pregnancy as a result of their inability to maintain adequate energy homoeostasis. Different alternative treatments are available with variable results. The aim of this research was to evaluate a peroxisome proliferator-activated receptor alpha (PPARα) stimulant as an alternative to treat clinical pregnancy toxaemia. Thirty-three adult sheep, with known gestation date and carrying a single foetus, were fasted from day 130 of gestation until animals showed clinical disease. From that moment onwards, sheep were treated during 6 days with three different therapeutic alternatives: 10 mg/kg of 2-methyl-2-phenoxy-propionic acid; 10 mg/kg of 2-methyl-2-phenoxy-propionic acid + 100 mL of propylene glycol oral; or 100 mL of propylene glycol oral. Glycaemia and serum β-hydroxybutyrate (BHOB) were determined daily. Liver biopsies were taken at day 130 of gestation, at the beginning and end of treatments and at 5 days postpartum, evaluating the extent and degree of the steatosis lesion. Even though in sheep treated with 2-methyl-2-phenoxy-propionic acid, serum concentrations of glucose and BHOB recovered more slowly, we conclude that 2-methyl-2-phenoxy-propionic acid alone or combined with propylene glycol can be used as an alternative to effectively treat fatty liver, and therefore pregnancy toxaemia.
authors.affiliation: Pathology Department, Veterinary Faculty, University of La República, Montevideo, Uruguay.
authors.forename: S
authors.initials: S
authors.lastname: Da Silva
authors.affiliation: Pathology Department, Veterinary Faculty, University of La República, Montevideo, Uruguay.
authors.forename: L G
authors.initials: LG
authors.lastname: Cal-Pereyra
authors.affiliation: Small Animals Department, Veterinary Faculty, University of La República, Montevideo, Uruguay.
authors.forename: A
authors.initials: A
authors.lastname: Benech
authors.affiliation: Center for Research and Advanced Studies in Animal Health, Faculty of Veterinary Medicine, Autonomous University of Mexico State, Toluca, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Acosta-Dibarrat
authors.affiliation: Medicine, Surgery and Anatomy Veterinary Department, Veterinary Faculty, University of León, León, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Martin
authors.affiliation: Pathology Department, Veterinary Faculty, University of La República, Montevideo, Uruguay.
authors.forename: M C
authors.initials: MC
authors.lastname: Abreu
authors.affiliation: Pathology Department, Veterinary Faculty, University of La República, Montevideo, Uruguay.
authors.forename: S
authors.initials: S
authors.lastname: Perini
authors.affiliation: Medicine, Surgery and Anatomy Veterinary Department, Veterinary Faculty, University of León, León, Spain.
authors.forename: J R
authors.identifier: http://orcid.org/0000-0002-8976-3332
authors.initials: JR
authors.lastname: González-Montaña
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood; D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D058607:Fibric Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D047493:PPAR alpha / Q000819:agonists*; D011225:Pre-Eclampsia / Q000188:drug therapy / Q000662:veterinary*; D011247:Pregnancy; D019946:Propylene Glycol / Q000008:administration & dosage / Q000627:therapeutic use*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*
chemical_list: D001786:Blood Glucose; D058607:Fibric Acids; D047493:PPAR alpha; C010285:fibric acid; D019946:Propylene Glycol; D020155:3-Hydroxybutyric Acid