title: Chromosomal aberrations in benign prostatic hyperplasia patients.
abstract: OBJECTIVE
  To investigate the chromosomal changes in patients with benign prostatic hyperplasia (BPH).
  
  
  METHODS
  A total of 54 patients diagnosed with clinical BPH underwent transurethral prostate resection to address their primary urological problem. All patients were evaluated by use of a comprehensive medical history and rectal digital examination. The preoperative evaluation also included serum prostate-specific antigen (PSA) measurement and ultrasonographic measurement of prostate volume. Prostate cancer was detected in one patient, who was then excluded from the study. We performed conventional cytogenetic analyses of short-term cultures of 53 peripheral blood samples obtained from the BPH patients.
  
  
  RESULTS
  The mean (±standard deviation) age of the 53 patients was 67.8±9.4 years. The mean PSA value of the patients was 5.8±7.0 ng/mL. The mean prostate volume was 53.6±22.9 mL. Chromosomal abnormalities were noted in 5 of the 53 cases (9.4%). Loss of the Y chromosome was the most frequent chromosomal abnormality and was observed in three patients (5.7%). There was no statistically significant relationship among age, PSA, prostate volume, and chromosomal changes.
  
  
  CONCLUSIONS
  Loss of the Y chromosome was the main chromosomal abnormality found in our study. However, this coexistence did not reach a significant level. Our study concluded that loss of the Y chromosome cannot be considered relevant for the diagnosis of BPH as it is for prostate cancer. Because BPH usually occurs in aging men, loss of the Y chromosome in BPH patients may instead be related to the aging process.
authors.affiliation: Department of Urology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Muammer
authors.initials: M
authors.lastname: Altok
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Özkan
authors.initials: Ö
authors.lastname: Bağcı
authors.affiliation: Department of Urology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Umul
authors.affiliation: Department of Urology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Güneş
authors.affiliation: Department of Urology, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Akyüz
authors.affiliation: Department of Urology, Fatih Sultan Mehmet Education and Research Hospital, İstanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Uruç
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Efkan
authors.initials: E
authors.lastname: Uz
authors.affiliation: Department of Urology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Sedat
authors.initials: S
authors.lastname: Soyupek
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D041322:Chromosomes, Human, Y / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D059785:Karyotype; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D020728:Transurethral Resection of Prostate
chemical_list: D017430:Prostate-Specific Antigen
keywords: Chromosomes; Genes; Hyperplasia; Prostate