title: De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging.
abstract: Fifteen to 20% of children with neurofibromatosis type 1 develop low-grade glial neoplasms. However, since neuroimaging is not routinely obtained until a child is clinically symptomatic, little is known about presymptomatic radiographic characteristics of gliomas in this at-risk population. Herein, we describe a child with neurofibromatosis type 1 who initially had normal brain imaging before the development of multifocal gliomas. Comparison of these serial images demonstrated that brain tumors can arise de novo in children with this cancer predisposition syndrome, further underscoring the limited prognostic value of normal baseline magnetic resonance imaging.
authors.affiliation: Department of Pediatrics, Washington University School of Medicine, Box 8116, 660 South Euclid Avenue, St. Louis, MO, USA.
authors.forename: Rabia
authors.initials: R
authors.lastname: Zafar
authors.affiliation: Department of Neurology, Washington University School of Medicine, Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
authors.forename: Esther Y
authors.initials: EY
authors.lastname: Hsiao
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Avenue, St. Louis, MO, USA; Department of Radiology, Washington University School of Medicine, Box 8131, 66 South Euclid Avenue, St. Louis, MO, USA.
authors.forename: Kelly N
authors.initials: KN
authors.lastname: Botteron
authors.affiliation: Mallinckrodt Institute of Radiology, Washington University School of Medicine, Box 8131, 66 South Euclid Avenue, St. Louis, MO, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: McKinstry
authors.affiliation: Department of Neurology, Washington University School of Medicine, Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Gutmann
keywords: Astrocytoma; Inherited cancer syndrome; Neuroimaging; T2-hyperintensities