title: Two new 28-nor-oleanane-type triterpene saponins from roots of Camellia oleifera and their cytotoxic activity.
abstract: Two new 28-nor-oleanane-type triterpene saponins, oleiferoside U (1), and oleiferoside V (2) were isolated from the 50% EtOH extract of the roots of Camellia oleifera C. Abel. Their structures were elucidated as camellenodiol 3β-O-β-d-galactopyranosyl-(1→2)-β-d-xylopyranosyl-(1→2)-[β-d-galactopyranosyl-(1→3)]-β-d-glucuronopyranoside and camellenodiol 3β-O-β-d-galactopyranosyl-(1→3)-β-d-xylopyranosyl-(1→2)-[β-d-galactopyranosyl-(1→3)]-β-d-glucuronopyranoside. Their chemical structures were established mainly on the basis of integrated spectroscopic techniques. In vitro, cytotoxic activities of the two new triterpene saponins were evaluated against three human tumor cell lines (A549, SMMC-7721, and MCF-7) using the MTT assay. Both of them showed a certain cytotoxic activities toward the tested cell lines and gave IC50 values in the range of 45.04-63.22 μM.
authors.affiliation: a College of Pharmaceutical Science , Soochow University , Suzhou 215123 , China.
authors.forename: Zi-Yu
authors.initials: ZY
authors.lastname: Zhang
authors.affiliation: a College of Pharmaceutical Science , Soochow University , Suzhou 215123 , China.
authors.forename: Jiang-Ping
authors.initials: JP
authors.lastname: Wu
authors.affiliation: a College of Pharmaceutical Science , Soochow University , Suzhou 215123 , China.
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Gao
authors.affiliation: a College of Pharmaceutical Science , Soochow University , Suzhou 215123 , China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Ren
authors.affiliation: a College of Pharmaceutical Science , Soochow University , Suzhou 215123 , China.
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Liu
authors.affiliation: a College of Pharmaceutical Science , Soochow University , Suzhou 215123 , China.
authors.forename: Xiao-Ran
authors.initials: XR
authors.lastname: Li
authors.affiliation: b College of Pharmaceutical Science , Guangdong Pharmaceutical University , Guangzhou 510006 , China.
authors.forename: Kun-Ping
authors.initials: KP
authors.lastname: Li
authors.affiliation: a College of Pharmaceutical Science , Soochow University , Suzhou 215123 , China.
authors.forename: Qiong-Ming
authors.initials: QM
authors.lastname: Xu
authors.affiliation: a College of Pharmaceutical Science , Soochow University , Suzhou 215123 , China.
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Yang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D028244:Camellia / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012503:Saponins; C413246:oleanane; D009828:Oleanolic Acid
keywords: Camellia oleifera; Theaceae; camellenodiol; cytotoxic activities; oleiferosides U–V