title: Effects of glia metabolism inhibition on nociceptive behavioral testing in rats.
abstract: Fluoroacetate has been widely used to inhibit glia metabolism in vivo. It has yet to be shown what the effects of chronic intrathecal infusion of fluoroacetate on nociceptive behavioral testing are. The effects of chronic infusion of fluoroacetate (5 nmoles/h) for 2 weeks were examined in normal rats. Chronic intrathecal fluoroacetate did not alter mechanical threshold (von Frey filaments), responses to supra-threshold mechanical stimuli (von Frey filaments), responses to hot (hot plate) or cool (acetone test) stimuli and did not affect motor performance of the animals, which was tested with rotarod. This suggests that fluoroacetate at appropriate dose did not suppress neuronal activity in the spinal cord.
authors.affiliation: Neurocentre Magendie, Inserm U1215, F-33000 Bordeaux, France; Univ. Bordeaux, F-33000 Bordeaux, France.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lefèvre
authors.affiliation: Neurocentre Magendie, Inserm U1215, F-33000 Bordeaux, France; Univ. Bordeaux, F-33000 Bordeaux, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Amadio
authors.affiliation: Neurocentre Magendie, Inserm U1215, F-33000 Bordeaux, France; Univ. Bordeaux, F-33000 Bordeaux, France.
authors.forename: Peggy
authors.initials: P
authors.lastname: Vincent
authors.affiliation: Clermont Université, Université d׳Auvergne, NEURO-DOL, BP 10448, F-63000 Clermont-Ferrand, France; Inserm, U1107, F-63001 Clermont-Ferrand, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Descheemaeker
authors.affiliation: Neurocentre Magendie, Inserm U1215, F-33000 Bordeaux, France; Univ. Bordeaux, F-33000 Bordeaux, France.
authors.forename: Stéphane H R
authors.initials: SH
authors.lastname: Oliet
authors.affiliation: Clermont Université, Université d׳Auvergne, NEURO-DOL, BP 10448, F-63000 Clermont-Ferrand, France; Inserm, U1107, F-63001 Clermont-Ferrand, France.
authors.forename: Radhouane
authors.initials: R
authors.lastname: Dallel
authors.affiliation: Neurocentre Magendie, Inserm U1215, F-33000 Bordeaux, France; Univ. Bordeaux, F-33000 Bordeaux, France.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Voisin
keywords: Fluoroacetate; Intrathecal; Nociception; Rat