title: Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population.
abstract: OBJECTIVE
  To investigate prevalence and risk factors for colorectal neoplasms in adults aged < 50 years, for whom screening is not recommended.
  
  
  METHODS
  This cross-sectional study compared prevalence and characteristics of colorectal and advanced adenomas in patients aged < 50 years who underwent colonoscopy screening with subjects aged ≥ 50 years. To evaluate risk factors for colorectal and advanced adenoma in young adults, we used multivariable logistic regression models. Colorectal neoplasm characteristics were evaluated and compared with those in older patients.
  
  
  RESULTS
  Among 2819 patients included, prevalences of colorectal adenoma and advanced adenoma were 19.7% and 1.5%, respectively. As patient age increased, so did the prevalence of colorectal neoplasm. However, prevalence of advanced adenoma did not differ between age-groups 45-49 years and ≥ 50 years (OR = 0.43, 95%CI: 0.17-1.07, P = 0.070). In younger age-group (< 50 years), colorectal adenoma was significantly associated with older age, waist circumference (OR = 1.72, 95%CI: 1.15-2.55, P = 0.008), and current smoking (OR = 1.60, 95%CI: 1.07-2.41, P = 0.023). Alcohol consumption was an independent risk factor for colorectal advanced adenoma (OR = 3.69, 95%CI: 1.08-12.54, P = 0.037). Multiple neoplasms and large neoplasms (≥ 1 cm) were more prevalent in subjects ≥ 50 years.
  
  
  CONCLUSIONS
  Current screening strategies for colorectal cancer may need to be amended to account for patient age, especially in young subjects with abdominal obesity, current smoking and alcohol consumption.
authors.affiliation: Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang, Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Dongguk, Goyang, Gyeonggi-do 410-773, South Korea.
authors.forename: Seung Eun
authors.initials: SE
authors.lastname: Lee
authors.affiliation: Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang, Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Dongguk, Goyang, Gyeonggi-do 410-773, South Korea.
authors.forename: Hee Bum
authors.initials: HB
authors.lastname: Jo
authors.affiliation: Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang, Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Dongguk, Goyang, Gyeonggi-do 410-773, South Korea.
authors.forename: Won Gun
authors.initials: WG
authors.lastname: Kwack
authors.affiliation: Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang, Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Dongguk, Goyang, Gyeonggi-do 410-773, South Korea.
authors.forename: Yun Jin
authors.initials: YJ
authors.lastname: Jeong
authors.affiliation: Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang, Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Dongguk, Goyang, Gyeonggi-do 410-773, South Korea.
authors.forename: Yeo-Jin
authors.initials: YJ
authors.lastname: Yoon
authors.affiliation: Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang, Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Dongguk, Goyang, Gyeonggi-do 410-773, South Korea.
authors.forename: Hyoun Woo
authors.initials: HW
authors.lastname: Kang
mesh_terms: D018256:Adenomatous Polyps / Q000453:epidemiology* / Q000473:pathology; D000328:Adult; D017668:Age of Onset; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology; D016009:Chi-Square Distribution; D003111:Colonic Polyps / Q000453:epidemiology* / Q000473:pathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology; D003430:Cross-Sectional Studies; D055088:Early Detection of Cancer / Q000379:methods; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D056128:Obesity, Abdominal / Q000453:epidemiology; D016017:Odds Ratio; D011237:Predictive Value of Tests; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology
keywords: Advanced adenoma; Cancer screening; Colorectal adenoma; Colorectal cancer; Young patients