title: Insights into kidney stem cell development and regeneration using zebrafish.
abstract: Kidney disease is an escalating global health problem, for which the formulation of therapeutic approaches using stem cells has received increasing research attention. The complexity of kidney anatomy and function, which includes the diversity of renal cell types, poses formidable challenges in the identification of methods to generate replacement structures. Recent work using the zebrafish has revealed their high capacity to regenerate the integral working units of the kidney, known as nephrons, following acute injury. Here, we discuss these findings and explore the ways that zebrafish can be further utilized to gain a deeper molecular appreciation of renal stem cell biology, which may uncover important clues for regenerative medicine.
authors.affiliation: Bridgette E Drummond, Rebecca A Wingert, Department of Biological Sciences, Center for Zebrafish Research, Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, United States.
authors.forename: Bridgette E
authors.initials: BE
authors.lastname: Drummond
authors.affiliation: Bridgette E Drummond, Rebecca A Wingert, Department of Biological Sciences, Center for Zebrafish Research, Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, United States.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Wingert
keywords: Blood filter; Kidney; Nephron; Regeneration; Renal corpuscle; Renal progenitor; Renal stem cell; Tubule