title: Epidemiological trends and characteristics of Japanese encephalitis changed based on the vaccination program between 1960 and 2013 in Guangxi Zhuang Autonomous Region, southern China.
abstract: Japanese encephalitis (JE) is one of the most severe kinds of viral encephalitis and is prevalent in Asia and the Western Pacific. In China, JE was first reported in the 1940s and became the main cause of viral encephalitis, including in the Guangxi Zhuang Autonomous Region. In 1951, JE was included in the Chinese mandatory disease reporting system. In the pre-vaccine era of the 1960s and 1970s, the incidence of JE continued to rise without any vaccine supply. Since JE vaccines became available in the late 1970s (MBD) and 1989 (LAV-SA-14-14-2), and as JE vaccine became freely available to patients beginning in 2008, the incidence of JE has declined significantly. Despite these gains, outbreaks continue to occur among children in rural and suburban areas. Strengthening vaccine delivery models and improving swine vaccine production are important in order to sustain continuous declines in the incidence of JE in Guangxi.
authors.affiliation: Section of Epidemiology and Statistics, School of Public Health, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Section of Epidemiology and Statistics, School of Public Health, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Nengxiu
authors.initials: N
authors.lastname: Liang
authors.affiliation: Section of Acute Communicable Diseases Control and Prevention, Guangxi Zhuang Autonomous Region Centre for Diseases Control and Prevention, Guangxi Zhuang Autonomous Region, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Section of Epidemiology and Statistics, School of Public Health, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. Electronic address: 357154887@qq.com.
authors.forename: Zhichun
authors.initials: Z
authors.lastname: Xie
mesh_terms: D000818:Animals; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004672:Encephalitis, Japanese / Q000453:epidemiology*; D005260:Female; D006801:Humans; D017589:Immunization Programs; D015994:Incidence; D022321:Japanese Encephalitis Vaccines / Q000276:immunology*; D008297:Male; D012621:Seasons; D013552:Swine; D013997:Time Factors
chemical_list: D022321:Japanese Encephalitis Vaccines
keywords: Characteristics; Guangxi; Japanese encephalitis; Vaccination program