title: Characterization of an RNA receptor motif that recognizes a GCGA tetraloop.
abstract: Tertiary interactions between a new RNA motif and RNA tetraloops were analyzed to determine whether this new motif shows preference for a GCGA tetraloop. In the structural context of a ligase ribozyme, this motif discriminated GCGA loop from 3 other tetraloops. The affinity between the GCGA loop and its receptor is strong enough to carry out the ribozyme activity.
authors.affiliation: a Department of Chemistry , Graduate School of Science and Engineering, University of Toyama , Toyama , Japan.
authors.forename: Airi
authors.initials: A
authors.lastname: Furukawa
authors.affiliation: a Department of Chemistry , Graduate School of Science and Engineering, University of Toyama , Toyama , Japan.
authors.forename: Takaya
authors.initials: T
authors.lastname: Maejima
authors.affiliation: a Department of Chemistry , Graduate School of Science and Engineering, University of Toyama , Toyama , Japan.
authors.forename: Shigeyoshi
authors.initials: S
authors.lastname: Matsumura
authors.affiliation: a Department of Chemistry , Graduate School of Science and Engineering, University of Toyama , Toyama , Japan.
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Ikawa
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D015870:Gene Expression; D059372:Nucleotide Motifs; D011485:Protein Binding; D015800:Protozoan Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D059370:RNA Folding; D016337:RNA, Catalytic / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D058928:Riboswitch; D013768:Tetrahymena / Q000235:genetics / Q000378:metabolism
chemical_list: D052157:Aptamers, Nucleotide; D015800:Protozoan Proteins; D016337:RNA, Catalytic; D058928:Riboswitch
keywords: GNRA tetraloop; RNA motif; riboswitch; ribozyme; tertiary interaction