title: Fulminant Type 1 Diabetes Mellitus Associated with Coxsackie Virus Type A2 Infection: A Case Report and Literature Review.
abstract: A 65-year-old Japanese man presented to our hospital in June 2013 with a 6-day history of fever and fatigue, a 24-h history of thirst, and polyuria. His temperature was 37.8°C and he was alert. However, laboratory tests revealed severe hyperglycemia, undetectable C-peptide levels, and diabetic ketoacidosis. Serum antibody testing confirmed a Coxsackie virus A2 infection. A variety of viral infections are reported to be involved in the development of fulminant type 1 diabetes mellitus (FT1D). Our patient is the first reported case of FT1D associated with Coxsackie virus A2 infection and supports the etiological role of common viral infections in FT1D.
authors.affiliation: Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Japan.
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Ohara
authors.forename: Masanori
authors.initials: M
authors.lastname: Kaneko
authors.forename: Takeaki
authors.initials: T
authors.lastname: Nishibori
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sato
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Furukawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Koike
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sone
authors.forename: Kenzo
authors.initials: K
authors.lastname: Kaneko
authors.forename: Kyuzi
authors.initials: K
authors.lastname: Kamoi
mesh_terms: D000208:Acute Disease; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D003384:Coxsackievirus Infections / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D016883:Diabetic Ketoacidosis / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D004770:Enterovirus / Q000276:immunology / Q000302:isolation & purification*; D005221:Fatigue / Q000209:etiology; D005334:Fever / Q000209:etiology; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D011141:Polyuria / Q000209:etiology; D013894:Thirst; D016896:Treatment Outcome
chemical_list: D000914:Antibodies, Viral; D007004:Hypoglycemic Agents; D007328:Insulin