title: Cerebrolysin improves sciatic nerve dysfunction in a mouse model of diabetic peripheral neuropathy.
abstract: To examine the effects of Cerebrolysin on the treatment of diabetic peripheral neuropathy, we first established a mouse model of type 2 diabetes mellitus by administering a high-glucose, high-fat diet and a single intraperitoneal injection of streptozotocin. Mice defined as diabetic in this model were then treated with 1.80, 5.39 or 8.98 mL/kg of Cerebrolysin via intraperitoneal injections for 10 consecutive days. Our results demonstrated that the number, diameter and area of myelinated nerve fibers increased in the sciatic nerves of these mice after administration of Cerebrolysin. The results of several behavioral tests showed that Cerebrolysin dose-dependently increased the slope angle in the inclined plane test (indicating an improved ability to maintain body position), prolonged tail-flick latency and foot-licking time (indicating enhanced sensitivity to thermal and chemical pain, respectively, and reduced pain thresholds), and increased an index of sciatic nerve function in diabetic mice compared with those behavioral results in untreated diabetic mice. Taken together, the anatomical and functional results suggest that Cerebrolysin ameliorated peripheral neuropathy in a mouse model of type 2 diabetes mellitus.
authors.affiliation: Department of Pediatric Neurology and Rehabilitation, First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Han-Yu
authors.initials: HY
authors.lastname: Dong
authors.affiliation: Institute of Jilin Neurological Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Xin-Mei
authors.initials: XM
authors.lastname: Jiang
authors.affiliation: Department of Pathology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Chun-Bo
authors.initials: CB
authors.lastname: Niu
authors.affiliation: Department of Pediatric Neurology and Rehabilitation, First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Du
authors.affiliation: Department of Pediatric Neurology and Rehabilitation, First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Jun-Yan
authors.initials: JY
authors.lastname: Feng
authors.affiliation: Department of Pediatric Neurology and Rehabilitation, First Hospital of Jilin University, Changchun, Jilin Province, China; Institute of Jilin Neurological Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Fei-Yong
authors.identifier: 0000-0002-8309-1395
authors.initials: FY
authors.lastname: Jia
keywords: Cerebrolysin; diabetes mellitus; nerve regeneration; neural regeneration; neurological function; peripheral neuropathy; sciatic nerve