title: Implication of protein tyrosine phosphatase SHP-1 in cancer-related signaling pathways.
abstract: The altered expression of SHP-1 (SH2 domain-containing protein tyrosine phosphatase) as a consequence of promoter hypermethylation or mutations has evidently been linked to cancer development. The notion of being a cancer drug target is conceivable as SHP-1 negatively regulates cell cycle and inflammatory pathways which are an inevitable part of oncogenic transformation. In the present review, we try to critically analyze the role of SHP-1 in cancer progression via regulating the above mentioned pathways with the major emphasis on cell cycle components and JAK/STAT pathway, commencing with the SHP-1 biology in immune cell signaling. Lastly, we have provided the future directions for researchers to encourage SHP-1 as a prognostic marker and curative target for this debilitating disease called as cancer.
authors.affiliation: Department of Biochemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062, India.
authors.forename: Yadhu
authors.initials: Y
authors.lastname: Sharma
authors.affiliation: Department of Botany, Aligarh Muslim University, Aligarh, Uttar Pradesh-202002, India.
authors.forename: Altaf
authors.initials: A
authors.lastname: Ahmad
authors.affiliation: Department of Biochemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062, India.
authors.forename: Samina
authors.initials: S
authors.lastname: Bashir
authors.affiliation: Centre for Cellular & Molecular Biology (Council for Scientific & Industrial Research), Uppal Road, Hyderabad, Telangana-500007, India.
authors.forename: Asif
authors.initials: A
authors.lastname: Elahi
authors.affiliation: Department of Biochemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062, India.
authors.forename: Farah
authors.initials: F
authors.lastname: Khan
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C509249:PTPN6 protein, human; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6
keywords: SHP-1; STAT3; cancer; cyclin dependent kinases; motheaten mice; p27kip1; viable motheaten mice