title: [Optic chiasm glioma in children: Endocrine disorders in 14 cases].
abstract: OBJECTIVE
  To describe the frequency of endocrine disorders in children with optic chiasm glioma and analyze related factors.
  
  
  METHODS
  Review of medical records by collecting sex, age, history of neurofibromatosis, clinical presentation, treatment of tumour, and presence of endocrine abnormalities. Statistical tests Wilcoxon and Fisher.
  
  
  RESULTS
  14 patients (6 female) with age at diagnosis of 0.5 to 7.0 years (mean±standard deviation: 2.97±2.32) and follow-up of 10.64±3.30 years (range 6.0 to 16.0). 12/14 presented endocrinopathy at follow-up: 8 precocious puberty, 5 hypopituitarism, and 5 obesity. The onset of deficits was related to the neuroophthalmological symptoms under the age of five (P=.02)and treatment of the tumour was required.(P=.03).
  
  
  CONCLUSIONS
  Children with optic chiasm gliomas may present endocrine disorders from the time of diagnosis of the tumor and, in particular as they develop on. The most common of these is precocious puberty. Pituitary deficits are associated with more aggressive tumours (those presenting with neuroophthalmological signs and symptoms before the age of five and requiring treatment).
authors.affiliation: Unidad de Endocrinología Pediátrica, Hospital Universitario «Virgen del Rocío», Sevilla, España. Electronic address: ejgg67@gmail.com.
authors.forename: Emilio
authors.initials: E
authors.lastname: García García
authors.affiliation: Unidad de Oncología Pediátrica, Hospital Universitario «Virgen del Rocío», Sevilla, España.
authors.forename: Catalina
authors.initials: C
authors.lastname: Márquez Vega
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Universitario «Virgen del Rocío», Sevilla, España.
authors.forename: Manuel
authors.initials: M
authors.lastname: Fajardo Cascos
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Universitario «Virgen del Rocío», Sevilla, España.
authors.forename: Eva
authors.initials: E
authors.lastname: Venegas Moreno
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Universitario «Virgen del Rocío», Sevilla, España.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Soto Moreno
mesh_terms: D002648:Child; D002675:Child, Preschool; D004700:Endocrine System Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000150:complications*; D006801:Humans; D007223:Infant; D008297:Male; D009897:Optic Chiasm; D019574:Optic Nerve Neoplasms / Q000150:complications*; D012189:Retrospective Studies
keywords: Childhood; Childhood optic nerve glioma; Glioma óptico de los niños; Hipopituitarismo; Hypopituitarism; Hypothalamic neoplasms; Neoplasias hipotalámicas; Niños; Precocious puberty; Pubertad precoz