title: The inflammatory markers in polycystic ovary syndrome: association with obesity and IVF outcomes.
abstract: OBJECTIVE
  To investigate the inflammatory markers in polycystic ovary syndrome (PCOS) and associations of these markers with obesity and in vitro fertilization (IVF) outcomes.
  
  
  METHODS
  A total of 292 women underwent IVF procedure either with PCOS (n = 146) or without PCOS (n = 146, age, and body mass index (BMI) matched controls) were included in the study. All patients were classified according to BMI levels (normal weight: NW, BMI <25 kg/m(2) and obese: OB, BMI ≥25 kg/m(2)). The inflammatory markers were leukocyte count, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV).
  
  
  RESULTS
  BMI of PCOS was positively correlated with leukocyte, neutrophil, lymphocyte and MPV (p < 0.05), but negatively correlated with NLR and PLR (p < 0.05). Both NLR and PLR increased significantly in PCOS (p < 0.001). PLR increased significantly in NW-PCOS compared the NW-controls and OB-PCOS. MPV values increased only in OB-PCOS subjects. The logistic regression analyzes showed that MPV was the independent variable in PCOS to effect CPR (p = 0.000; OR 0.1; CI 0.06-0.2).
  
  
  CONCLUSIONS
  NLR and PLR were significantly increased in all PCOS subjects compared to the BMI-matched controls. Despite PLR being decreased by adiposity, PLR increased in NW-PCOS. These results are supporting the hypothesis that PCOS is a chronic inflammatory process independent of obesity. MPV levels were independently associated with CPR in PCOS. Further prospective studies concerning inflammation and IVF outcomes of PCOS are needed.
authors.affiliation: Obstetrics and Gynecology Department, Kocaeli University School of Medicine, Kocaeli, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Çakıroğlu
authors.affiliation: Obstetrics and Gynecology Clinic, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey. fisunvural@yahoo.com.tr.
authors.forename: F
authors.initials: F
authors.lastname: Vural
authors.affiliation: Obstetrics and Gynecology Department, Kocaeli University School of Medicine, Kocaeli, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Vural
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D001792:Blood Platelets / Q000473:pathology; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology* / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D009765:Obesity / Q000097:blood / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers
keywords: IVF outcomes; Inflammation; Mean platelet volume; Neutrophil/lymphocyte ratio; Platelet/lymphocyte ratio; Polycystic ovary syndrome