title: Glomerular disease with idiopathic linear immunoglobulin deposition: a rose by any other name would be atypical.
abstract: Nasr et al. (2016) report 20 cases of "atypical anti-GBM disease," characterized by bright, linear glomerular basement membrane (GBM) immunoglobulin deposition in patients who lacked anti-GBM antibodies by conventional testing and who had a relatively benign course. Half had light chain restriction. The term "idiopathic linear immunoglobulin deposition" may be preferable until anti-GBM activity is demonstrable, since there are alternative mechanisms of linear deposition in the GBM, including physicochemical affinity for GBM components and alterations of the GBM itself.
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Ivy A
authors.initials: IA
authors.lastname: Rosales
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address: colvin@helix.mgh.harvard.edu.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Colvin
mesh_terms: D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology; D050533:Glomerular Basement Membrane; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology; D027826:Rosa
chemical_list: D007074:Immunoglobulin G