title: AC and DC electrospinning of hydroxypropylmethylcellulose with polyethylene oxides as secondary polymer for improved drug dissolution.
abstract: Alternating current electrospinning (ACES) capable to reach multiple times higher specific productivities than widely used direct current electrospinning (DCES) was investigated and compared with DCES to prepare drug-loaded formulations based on one of the most widespread polymeric matrix used for commercialized pharmaceutical solid dispersions, hydroxypropylmethylcellulose 2910 (HPMC). In order to improve the insufficient spinnability of HPMC (both with ACES and DCES) polyethylene oxide (PEO) as secondary polymer with intense ACES activity was introduced into the electrospinning solution. Different grades of this polymer used at as low concentrations in the fibers as 0.1% or less enabled the production of high quality HPMC-based fibrous mats without altering its physicochemical properties remarkably. Increasing concentrations of higher molecular weight PEOs led to the thickening of fibers from submicronic diameters to several microns of thickness. ACES fibers loaded with the poorly water-soluble model drug spironolactone were several times thinner than drug-loaded fibers prepared with DCES in spite of the higher feeding rates applied. The amorphous HPMC-based fibers with large surface area enhanced the dissolution of spironolactone significantly, the presence of small amounts of PEO did not affect the dissolution rate. The presented results confirm the diverse applicability of ACES, a novel technique to prepare fibrous drug delivery systems.
authors.affiliation: Budapest University of Technology and Economics, Organic Chemistry and Technology Department, H-1111 Budapest, Hungary. Electronic address: baloghattila5@gmail.com.
authors.forename: Attila
authors.initials: A
authors.lastname: Balogh
authors.affiliation: Budapest University of Technology and Economics, Organic Chemistry and Technology Department, H-1111 Budapest, Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Farkas
authors.affiliation: Chemical and Pharmaceutical Development, Johnson & Johnson Pharmaceutical Research and Development, Janssen Pharmaceutica, B-2340 Beerse, Belgium.
authors.forename: Geert
authors.initials: G
authors.lastname: Verreck
authors.affiliation: Chemical and Pharmaceutical Development, Johnson & Johnson Pharmaceutical Research and Development, Janssen Pharmaceutica, B-2340 Beerse, Belgium.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Mensch
authors.affiliation: Budapest University of Technology and Economics, Organic Chemistry and Technology Department, H-1111 Budapest, Hungary.
authors.forename: Enikő
authors.initials: E
authors.lastname: Borbás
authors.affiliation: Budapest University of Technology and Economics, Organic Chemistry and Technology Department, H-1111 Budapest, Hungary.
authors.forename: Brigitta
authors.initials: B
authors.lastname: Nagy
authors.affiliation: Budapest University of Technology and Economics, Organic Chemistry and Technology Department, H-1111 Budapest, Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Marosi
authors.affiliation: Budapest University of Technology and Economics, Organic Chemistry and Technology Department, H-1111 Budapest, Hungary. Electronic address: zsknagy@oct.bme.hu.
authors.forename: Zsombor Kristóf
authors.initials: ZK
authors.lastname: Nagy
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D004560:Electricity; D065347:Hypromellose Derivatives / Q000737:chemistry*; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013148:Spironolactone / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D013148:Spironolactone; D065347:Hypromellose Derivatives; D011092:Polyethylene Glycols
keywords: Dissolution enhancement; Electrospinning; Hypromellose; Nanofibers; Polyethylene oxide