title: New photosensitive nanometric graphite oxide composites as antimicrobial material with prolonged action.
abstract: A new conjugate material based on partially reduced graphite oxide (rGO), silver nanoparticles (Ag), and bis(lysinato)zirconium(IV) phthalocyanine complex (ZrPc) was obtained. Its optical properties (absorption and photoluminescence) after dispersion in solvents were examined. The antimicrobial properties were tested to determine the effect of the composite on the following bacterial strains: Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, which are responsible for many infections and are one of the pathogens the most difficult to treatment. The results obtained for rGO-ZrPc-Ag composite were compared with the properties of GO, GO-ZrPc, and rGO-Ag structures. The influence of the near-infrared irradiation on the antimicrobial activity of ZrPc- and Ag-doped materials against bacteria was observed for very low concentration (0.32mg/mL) of GO-ZrPc to stop the growth of P. aeruginosa in comparison to the nonirradiated sample (41mg/mL). The usefulness of this material in therapy, such as wound infection treatment or endodontic treatment, as antibacterial agent with sustained action was discussed.
authors.affiliation: Institute of Low Temperature and Structure Research, Polish Academy of Sciences, 2 Okolna St., 50-422 Wroclaw, Poland. Electronic address: j.gerasymchuk@int.pan.wroc.pl.
authors.forename: Y
authors.initials: Y
authors.lastname: Gerasymchuk
authors.affiliation: Institute of Low Temperature and Structure Research, Polish Academy of Sciences, 2 Okolna St., 50-422 Wroclaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Lukowiak
authors.affiliation: Institute of Low Temperature and Structure Research, Polish Academy of Sciences, 2 Okolna St., 50-422 Wroclaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Wedzynska
authors.affiliation: Institute of Genetics and Microbiology, Department of Microbiology, Faculty of Biological Sciences, University of Wroclaw, 63/77 Przybyszewskiego St., 51-148 Wroclaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Kedziora
authors.affiliation: Institute of Genetics and Microbiology, Department of Microbiology, Faculty of Biological Sciences, University of Wroclaw, 63/77 Przybyszewskiego St., 51-148 Wroclaw, Poland.
authors.forename: G
authors.initials: G
authors.lastname: Bugla-Ploskonska
authors.affiliation: Department of Conservative Dentistry and Endodontics, F. Skubiszewski Medical University, 1 Racławickie Ave., 20-059 Lublin, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Piatek
authors.affiliation: Department of Conservative Dentistry and Endodontics, F. Skubiszewski Medical University, 1 Racławickie Ave., 20-059 Lublin, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Bachanek
authors.affiliation: V.I. Vernadskii Institute of General and Inorganic Chemistry, 32/34 Palladin Ave., Kiev, Ukraine.
authors.forename: V
authors.initials: V
authors.lastname: Chernii
authors.affiliation: V.I. Vernadskii Institute of General and Inorganic Chemistry, 32/34 Palladin Ave., Kiev, Ukraine.
authors.forename: L
authors.initials: L
authors.lastname: Tomachynski
authors.affiliation: Institute of Low Temperature and Structure Research, Polish Academy of Sciences, 2 Okolna St., 50-422 Wroclaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Strek
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000254:growth & development*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007259:Infrared Rays; D053768:Metal Nanoparticles / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D012834:Silver; D006108:Graphite
keywords: Bacteriostatic; Graphite oxide; NIR irradiation; Nanocomposite; Phthalocyanine; Silver nanoparticles