title: An Acetyldegron Triggers CRBN to Take Down the "Q".
abstract: In this issue of Molecular Cell, Nguyen et al. (2016) show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4(CRBN) E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations.
authors.affiliation: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.
authors.forename: Sajjan
authors.initials: S
authors.lastname: Koirala
authors.affiliation: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA. Electronic address: ryan.potts@stjude.org.
authors.forename: Patrick Ryan
authors.initials: PR
authors.lastname: Potts
mesh_terms: D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D007155:Immunologic Factors; D044767:Ubiquitin-Protein Ligases; D010447:Peptide Hydrolases; D005974:Glutamate-Ammonia Ligase