title: A search for synbiotics: effects of enzymatically modified arabinoxylan and Butyrivibrio fibrisolvens on short-chain fatty acids in the cecum content and plasma of rats.
abstract: Identification of dietary strategies to increase large intestinal production and absorption of short-chain fatty acids (SCFAs), especially butyrate, is of great interest due to the possible health promoting effects. We explored the effect of an enzymatically modified arabinoxylan-rich diet (EAXD) versus a Western-style control diet (WSD) low in dietary fiber with or without orally administrated Butyrivibrio fibrisolvens, a butyrate producer, on the SCFA pool in the cecal content and feces and the SCFA concentration in the blood of rats. The pool of acetate, butyrate and total SCFA was more than double in the cecal content from EAXD-fed rats compared with WSD-fed rats, and this was also reflected as an increase in portal plasma SCFA concentrations. Acetate, propionate and total SCFA concentrations were higher in mixed venous plasma following the EAXD. The number of B. fibrisolvens did not increase significantly in cecal content following administration of the bacteria. Furthermore, there was no interaction between the EAXD and B. fibrisolvens on the measured parameters.
authors.affiliation: Department of Animal Science, Aarhus University, Denmark. TinaS.Nielsen@anis.au.dk TinaS.Nielsen@anis.au.dk.
authors.forename: Tina S
authors.initials: TS
authors.lastname: Nielsen
authors.affiliation: Department of Animal Science, Aarhus University, Denmark. TinaS.Nielsen@anis.au.dk TinaS.Nielsen@anis.au.dk.
authors.forename: Bent B
authors.initials: BB
authors.lastname: Jensen
authors.affiliation: Department of Animal Science, Aarhus University, Denmark. TinaS.Nielsen@anis.au.dk TinaS.Nielsen@anis.au.dk.
authors.forename: Stig
authors.initials: S
authors.lastname: Purup
authors.affiliation: Department of Animal Science, University of Illinois, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Jackson
authors.affiliation: DuPont, Nutrition and Health, Finland.
authors.forename: Markku
authors.initials: M
authors.lastname: Saarinen
authors.affiliation: DuPont, Nutrition and Health, Finland.
authors.forename: Anna
authors.initials: A
authors.lastname: Lyra
authors.affiliation: DuPont, Industrial Biosciences, Denmark.
authors.forename: Jens F
authors.initials: JF
authors.lastname: Sørensen
authors.affiliation: Department of Animal Science, Aarhus University, Denmark. TinaS.Nielsen@anis.au.dk TinaS.Nielsen@anis.au.dk.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Theil
authors.affiliation: Department of Animal Science, Aarhus University, Denmark. TinaS.Nielsen@anis.au.dk TinaS.Nielsen@anis.au.dk.
authors.forename: Knud Erik B
authors.initials: KE
authors.lastname: Knudsen
mesh_terms: D000818:Animals; D002087:Butyrates / Q000378:metabolism; D000070097:Butyrivibrio fibrisolvens / Q000378:metabolism*; D002432:Cecum / Q000378:metabolism* / Q000382:microbiology; D044602:Cellulases / Q000737:chemistry; D004032:Diet; D004043:Dietary Fiber / Q000378:metabolism; D043364:Endo-1,4-beta Xylanases / Q000737:chemistry; D005232:Fatty Acids, Volatile / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D000069196:Gastrointestinal Microbiome; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D058616:Synbiotics / Q000008:administration & dosage / Q000032:analysis*; D014990:Xylans / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D002087:Butyrates; D004043:Dietary Fiber; D005232:Fatty Acids, Volatile; D014990:Xylans; C085118:arabinoxylan; D044602:Cellulases; D043364:Endo-1,4-beta Xylanases