title: [RATIONAL COMBINATION OF MEDICATIONS FOR THE TREATMENT OF VASCULAR PATHOLOGY IN GERIATRICS].
abstract: We undertook retrospective analysis of combination of medications recommended for the long-term treatment of co-morbid vascular pathology (arterial hypertension + coronary heart disease + vascular atherosclerosis) in elderly patients (women, mean age 73 ± 4 yr) hospitalized in a multidisciplinary clinic of the Perm krai from January 2010 to December 2014. Data on the interaction (type A reactions) of concurrently prescribed drugs were compared with those of the National Register of Medicinal Remedies and WHO Classification of Adverse Drug Reactions. Polypragmasia was found to be a characteristic feature of all recommended combinations (4-5 medications were simultaneously prescribed to 56.7% of the patients and 6 or more drugs to 43.3% of them). Nine combinations of drugs were distinguished among those prescribed to elderly patients with vascular co-morbidity. Probability and peculiarities of their interaction (type A reactions) were analyzed and optimal combinations in terms of safety for the treatment of vascular co-morbidity identified.
authors.forename: S E
authors.initials: SE
authors.lastname: Kozlov
authors.forename: I A
authors.initials: IA
authors.lastname: Kirshchina
authors.forename: Yu S
authors.initials: YS
authors.lastname: Gabdrafikova
authors.forename: A V
authors.initials: AV
authors.lastname: Soloninina
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000188:drug therapy* / Q000209:etiology; D015897:Comorbidity; D003327:Coronary Disease / Q000188:drug therapy* / Q000209:etiology; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005853:Geriatrics / Q000592:standards*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D019338:Polypharmacy