title: An open trial of Omega-3 fatty acids for depression in pregnancy.
abstract: OBJECTIVE
  In this flexible-dose, open-label trial, we examined the efficacy of omega-3 fatty acids for the treatment of depression during pregnancy.
  
  
  METHODS
  Fifteen pregnant women with major depressive episodes participated. Subjects initially received two capsules per day [0.93 g of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)]; the dose could be increased by one capsule per day every 2 weeks to a maximal dose of 2.8 g. Subjects were assessed with the Edinburgh Postnatal Depression Scale (EPDS) and Hamilton Rating Scale for Depression (HRSD).
  
  
  RESULTS
  Average duration of participation in this treatment trial was 8.3 weeks (SD ± 7.1). Average final dose of EPA + DHA in this flexible dose trial was 1.9 g per day (±0.5). The mean reduction in EPDS scores was 40.9% (SD ± 21.9); the mean decrease in HRSD score was 34.1% (SD ± 27.1).
  
  
  CONCLUSIONS
  This open trial provides data to support the need for randomized controlled dose-finding trials of omega-3 fatty acids in major depressive episodes during pregnancy.
authors.affiliation: 1Women's Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, USA.
authors.forename: Marlene P
authors.initials: MP
authors.lastname: Freeman
authors.affiliation: 3National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Hibbeln
authors.affiliation: 4Department of Psychiatry, Obstetrics and Gynecology, Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Wisner
authors.affiliation: 1Women's Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, USA.
authors.forename: Marcy
authors.initials: M
authors.lastname: Watchman
authors.affiliation: 2Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, USA.
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Gelenberg