title: Effects of nasal CPAP on exhaled SIRT1 and tumor necrosis factor-α in patients with obstructive sleep apnea.
abstract: Exhaled breath condensate (EBC) has been used to examine airway inflammation and oxidative stress. This study aimed to evaluate if there were abnormal Sirtuin 1 (SIRT1) protein and tumor necrosis factor (TNF)-α levels in EBC and to determine if these levels could be improved after nasal continuous positive airway pressure (CPAP) treatment. Thirty-five patients with moderately severe to severe obstructive sleep apnea syndrome (OSAS) who wanted nasal CPAP treatment and 20 healthy controls were prospectively enrolled. The EBC SIRT1 protein levels and EBC TNF-α protein levels were assessed by ELISA. All patients underwent sleep studies that were repeated 3 months after nasal CPAP treatment in patients with OSAS. Results showed that in OSAS before nasal CPAP treatment, the EBC SIRT1 protein levels were lower than that in normal subjects, whereas the EBC TNF-α protein levels were higher. After nasal CPAP treatment, the EBC SIRT1 levels increased and EBC TNF-α levels decreased. In conclusion, successful treatment of OSAS by nasal CPAP can normalize the levels of EBC SIRT1 and EBC TNF-α.
authors.affiliation: Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. Electronic address: cclin@mmh.org.tw.
authors.forename: Ching-Chi
authors.initials: CC
authors.lastname: Lin
authors.affiliation: Chest Division, Department of Internal Medicine, Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: Shwu-Fang
authors.initials: SF
authors.lastname: Liaw
authors.affiliation: Chest Division, Department of Internal Medicine, Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: Chung-Hsin
authors.initials: CH
authors.lastname: Chiu
authors.affiliation: Chest Division, Department of Internal Medicine, Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan; Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan.
authors.forename: Wei-Ji
authors.initials: WJ
authors.lastname: Chen
authors.affiliation: Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
authors.forename: Mei-Wei
authors.initials: MW
authors.lastname: Lin
authors.affiliation: Chest Division, Department of Internal Medicine, Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: Feng-Ting
authors.initials: FT
authors.lastname: Chang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001944:Breath Tests; D045422:Continuous Positive Airway Pressure; D004797:Enzyme-Linked Immunosorbent Assay; D045853:Exhalation; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D056564:Sirtuin 1 / Q000378:metabolism*; D020181:Sleep Apnea, Obstructive / Q000378:metabolism* / Q000628:therapy*; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Exhaled breath condensate; Nasal continuous positive airway pressure; Obstructive sleep apnea syndrome; Sirtuin 1; Tumor necrosis factor-α