title: Diagnostic potential of PET/CT using a68Ga-labelled prostate-specific membrane antigen ligand in whole-body staging of renal cell carcinoma: initial experience.
abstract: OBJECTIVE
  To evaluate the diagnostic potential of whole-body PET/CT using a68Ga-labelled PSMA ligand in renal cell carcinoma (RCC).
  
  
  METHODS
  Six patients with histopathologically proven RCC underwent68Ga-PSMA PET/CT. Each PET/CT scan was evaluated in relation to lesion count, location and dignity. SUVmax was measured in primary tumours and PET-positive metastases. Tumour-to-background SUVmax ratios (TBRSUVmax) were calculated for primary RCCs in relation to the surrounding normal renal parenchyma. Metastasis-to-background SUVmax ratios (MBRSUVmax) were calculated for PET-positive metastases in relation to gluteal muscle.
  
  
  RESULTS
  Five primary RCCs and 16 metastases were evaluated. The mean SUVmax of the primary RCCs was 9.9 ± 9.2 (range 1.7 - 27.2). Due to high uptake in the surrounding renal parenchyma, the mean TBRSUVmaxof the primary RCCs was only 0.2 ± 0.3 (range 0.02 - 0.7). Eight metastases showed focal68Ga-PSMA uptake (SUVmax 9.9 ± 8.3, range 3.4 - 25.6). The mean MBRSUVmaxof these PET-positive metastases was 11.7 ± 0.2 (range 4.4 - 28.1). All PET-negative metastases were subcentimetre lung metastases.
  
  
  CONCLUSIONS
  68Ga-PSMA PET/CT appears to be a promising method for detecting RCC metastases. However, no additional diagnostic value in assessing the primary tumour was found.
authors.affiliation: Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Germany. linomorris.sawicki@med.uni-duesseldorf.de.
authors.forename: Lino M
authors.initials: LM
authors.lastname: Sawicki
authors.affiliation: Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Buchbender
authors.affiliation: Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Boos
authors.affiliation: Medical Faculty, Department of Urology, University Dusseldorf, 40225, Dusseldorf, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Giessing
authors.affiliation: Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Juelich Research Center, 52425, Juelich, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Ermert
authors.affiliation: Medical Faculty, Department of Nuclear Medicine, University Dusseldorf, 40225, Dusseldorf, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Antke
authors.affiliation: Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Germany.
authors.forename: Gerald
authors.initials: G
authors.lastname: Antoch
authors.affiliation: Medical Faculty, Department of Nuclear Medicine, University Dusseldorf, 40225, Dusseldorf, Germany.
authors.forename: Hubertus
authors.initials: H
authors.lastname: Hautzel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000378:metabolism*; D004492:Edetic Acid / Q000031:analogs & derivatives; D005260:Female; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009842:Oligopeptides; D009942:Organometallic Compounds; D010865:Pilot Projects; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D051598:Whole Body Imaging / Q000379:methods*
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; D004492:Edetic Acid
keywords: Gallium-68; PET/CT; PSMA; Renal cell carcinoma