title: Unusual Electromyographic Findings Associated With Colchicine Neuromyopathy: A Case Report.
abstract: An 83-year-old man with multiple medical problems, including gout, pseudogout, and renal insufficiency, presented with more than a year of proximal weakness. He had an extensive previous medical workup, including a normal creatinine kinase. His weakness persisted despite endurance and strength training. Electrodiagnostic findings were consistent with a myopathy, although without abnormal spontaneous activity and a length-dependent neuropathy. On the basis of these findings, colchicine was discontinued. The patient experienced marked symptomatic improvement within a week. Myopathies with neuropathies may be found with the use of colchicine. This case was unusual because of the absence of abnormal spontaneous activity and increased creatinine kinase, as typically reported with colchicine myopathy.
  
  
  
  V.
authors.affiliation: Departments of Physical Medicine and Rehabilitation and Neurology, Northwestern University; and Rehabilitation Institute of Chicago, Room 1154, 345 E. Superior, Chicago, IL 60611.
authors.forename: Christina
authors.initials: C
authors.lastname: Marciniak
authors.affiliation: Department of Physical Medicine and Rehabilitation, Harvard Medical School, and Spaulding Rehabilitation Hospital, Boston, MA.
authors.forename: Ashwin
authors.initials: A
authors.lastname: Babu
authors.affiliation: Midwest Orthopedics at Rush University Medical Center, Chicago, IL.
authors.forename: Leda
authors.initials: L
authors.lastname: Ghannad
authors.affiliation: North Shore Pediatrics, Evanston, IL.
authors.forename: Richard
authors.initials: R
authors.lastname: Burnstine
authors.affiliation: Departments of Physical Medicine and Rehabilitation and Neurology, Chicago, IL.
authors.forename: Susan
authors.initials: S
authors.lastname: Keeshin
mesh_terms: D000369:Aged, 80 and over; D003078:Colchicine; D006073:Gout; D006801:Humans; D008297:Male; D009468:Neuromuscular Diseases
chemical_list: D003078:Colchicine