title: Allotransplantation of macroencapsulated parathyroid cells as a treatment of severe postsurgical hypoparathyroidism: case report.
abstract: Persistent hypoparathyroidism, a condition associated with major inconvenience and potential morbidity, is more difficult to treat than other hypofunctional endocrine disorders. Therapeutic alternative in severe postsurgical hypoparathyroidism is allotransplantation of macroencapsulated parathyroid cells. With this technique, it is possible to implant cells or tissues of parathyroid origin to replace them in such patients without immunosuppression. At the present time, durable results have only been reported in parathyroid allotransplantation when immunosuppression to prevent rejection is administered. We report an allotransplant of parathyroid cells in a patient with continuous endovenous requirement of calcium to survive. Macrocapsule containing ~(20 to 30)x106 parathyroid cells was constructed with a polyvinylidine difluoride and implanted into the deep femoral artery. The functional activity of the graft, traced for 3 months, allowed to exclude the parenteral administration of calcium and to compensate symptoms of the disease.
  There have been no more than 3 previous clinical reports of similar parathyroid cell allotransplantation without immunosuppression.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Khryshchanovich
authors.forename: Youssef
authors.initials: Y
authors.lastname: Ghoussein
mesh_terms: D000328:Adult; D002118:Calcium / Q000008:administration & dosage; D017690:Cell Transplantation / Q000379:methods*; D005260:Female; D005263:Femoral Artery; D006801:Humans; D007011:Hypoparathyroidism / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D010280:Parathyroid Glands / Q000166:cytology*; D011183:Postoperative Complications / Q000628:therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D002118:Calcium