title: Intramolecular Functionalization of Benzylic Methylene Adjacent to the Ring Nitrogen Atom in N-Aryltetrahydroisoquinoline Derivatives.
abstract: Functionalization at the benzylic methylene group that is adjacent to the ring nitrogen atom in a series of N-aryltetrahydroisoquinoline compounds has been realized through intramolecular cross-dehydrogenative coupling reactions. The presented transformation provided straightforward access to the formation of C(sp(3))-Y (Y = C, N or O) bond via I(III) reagent.
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: Concordia International School Shanghai , Shanghai 201206, China.
authors.forename: Daisy
authors.initials: D
authors.lastname: Zhang-Negrerie
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Zhao
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300072, China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Du