title: Genetic distribution of 15 autosomal STR markers in the Punjabi population of Pakistan.
abstract: Genetic diversity of 15 autosomal short tandem repeat (STR) loci was evaluated in 713 unrelated individual samples of a Punjabi population of Pakistan. These loci were scrutinized to establish allelic frequencies and statistical parameters of forensic and paternity interests. A total of 165 alleles were observed with the corresponding allele frequencies ranging from 0.001 to 0.446. D2S1338 was found as the most informative locus while TPOX (0.611) was the least discriminating locus. The combined power of discrimination (CPD), the combined probability of exclusion (CPE), and cumulative probability of matching (CPM) were found equaled to 0.999999999999999998606227424808, 0.999995777557989, and 1.37543 × 10-18, respectively. All the loci followed the Hardy-Weinberg equilibrium after the Bonferroni correction (p < 0.0033) except one locus D3S1358. The study revealed that these STR loci are highly polymorphic, suitable for forensic and parentage analyses. In comparison to different populations (Asians and non-Asians), significant differences were recorded for these loci.
authors.affiliation: Centre for Applied Molecular Biology (CAMB), University of the Punjab, Lahore, Punjab, Pakistan.
authors.forename: Muhammad Adnan
authors.initials: MA
authors.lastname: Shan
authors.affiliation: Centre for Applied Molecular Biology (CAMB), University of the Punjab, Lahore, Punjab, Pakistan. manzoor.camb@pu.edu.pk.
authors.forename: Manzoor
authors.initials: M
authors.lastname: Hussain
authors.affiliation: Centre for Applied Molecular Biology (CAMB), University of the Punjab, Lahore, Punjab, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Shafique
authors.affiliation: Centre for Applied Molecular Biology (CAMB), University of the Punjab, Lahore, Punjab, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Shahzad
authors.affiliation: Centre for Applied Molecular Biology (CAMB), University of the Punjab, Lahore, Punjab, Pakistan.
authors.forename: Rukhsana
authors.initials: R
authors.lastname: Perveen
authors.affiliation: Centre for Applied Molecular Biology (CAMB), University of the Punjab, Lahore, Punjab, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Idrees
mesh_terms: D016172:DNA Fingerprinting; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers; D005828:Genetics, Population; D006801:Humans; D018895:Microsatellite Repeats; D010154:Pakistan; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers
keywords: Allelic frequencies; Autosomal STRs; Forensic; Genetic polymorphism; Pakistan; Punjabi population