title: Glucose-induced abnormal egg-laying rate in Caenorhabditis elegans.
abstract: High glucose reduced the egg-laying rate of the nematode Caenorhabditis elegans and was dependent on serotonergic signaling. Antidiabetic drugs of the biguanide and thiazolidine classes ameliorated the detrimental effect of glucose on egg-laying rate, suggesting the possibility that this quick and easy assay system may be applicable to whole-animal screening for novel antidiabetic drugs, at least, of these classes.
authors.affiliation: a Department of Applied Life Science , Sojo University , Kumamoto , Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Teshiba
authors.affiliation: a Department of Applied Life Science , Sojo University , Kumamoto , Japan.
authors.forename: Kohji
authors.initials: K
authors.lastname: Miyahara
authors.affiliation: a Department of Applied Life Science , Sojo University , Kumamoto , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takeya
mesh_terms: D000818:Animals; D001645:Biguanides / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000502:physiology; D052284:Clutch Size / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005947:Glucose / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D057166:High-Throughput Screening Assays; D007004:Hypoglycemic Agents / Q000494:pharmacology; D052287:Oviparity / Q000502:physiology; D010058:Oviposition / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000378:metabolism; D015398:Signal Transduction; D053778:Thiazolidines / Q000494:pharmacology; D015053:Zygote / Q000187:drug effects*
chemical_list: D001645:Biguanides; D007004:Hypoglycemic Agents; D053778:Thiazolidines; D012701:Serotonin; D005947:Glucose
keywords: C. elegans; diabetes mellitus; egg-laying; glucose toxicity; serotonin