title: Simulation study of electric-guided delivery of 0.4µm monodisperse and polydisperse aerosols to the ostiomeatal complex.
abstract: Despite the high prevalence of rhinosinusitis, current inhalation therapy shows limited efficacy due to extremely low drug delivery efficiency to the paranasal sinuses. Novel intranasal delivery systems are needed to enhance targeted delivery to the sinus with therapeutic dosages. An optimization framework for intranasal drug delivery was developed to target polydisperse charged aerosols to the ostiomeatal complex (OMC) with electric guidance. The delivery efficiency of a group of charged aerosols recently reported in the literature was numerically assessed and optimized in an anatomically accurate nose-sinus model. Key design variables included particle charge number, particle size and distribution, electrode strength, and inhalation velocity. Both monodisperse and polydisperse aerosol profiles were considered. Results showed that the OMC delivery efficiency was highly sensitive to the applied electric field and electrostatic charges carried by the particles. Through the synthesis of electric-guidance and point drug release, focused deposition with significantly enhanced dosage in the OMC can be achieved. For 0.4 µm charged aerosols, an OMC delivery efficiency of 51.6% was predicted for monodisperse aerosols and 34.4% for polydisperse aerosols. This difference suggested that the aerosol profile exerted a notable effect on intranasal deliveries. Sensitivity analysis indicated that the OMC deposition fraction was highly sensitive to the charge and size of particles and was less sensitive to the inhalation velocity considered in this study. Experimental studies are needed to validate the numerically optimized designs. Further studies are warranted to investigate the targeted OMC delivery with both electric and acoustics controls, the latter of which has the potential to further deliver the drug particles into the sinus cavity.
authors.affiliation: School of Engineering and Technology, Central Michigan University, 1200 South Franklin Street, Mount Pleasant, MI 48858, USA. Electronic address: xi1j@cmich.edu.
authors.forename: Jinxiang
authors.initials: J
authors.lastname: Xi
authors.affiliation: School of Engineering and Technology, Central Michigan University, 1200 South Franklin Street, Mount Pleasant, MI 48858, USA.
authors.forename: Jiayao Eddie
authors.initials: JE
authors.lastname: Yuan
authors.affiliation: Department of Mechanical Engineering, California Baptist University, Riverside, CA, USA.
authors.forename: Xiuhua April
authors.initials: XA
authors.lastname: Si
mesh_terms: D000336:Aerosols; D004560:Electricity; D006801:Humans; D008962:Models, Theoretical; D010316:Particle Size; D012852:Sinusitis / Q000188:drug therapy*
chemical_list: D000336:Aerosols
keywords: Charged particles; Electric guidance; Maxillary sinus; Ostiomeatal complex OMC; Rhinosinusitis