title: Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery.
abstract: In recent years there has been tremendous interest in both the basic biology and applications of extracellular vesicles (EVs) in translational cancer research. This includes a better understanding of their biogenesis and mechanisms of selective cargo packaging, their precise roles in horizontal communication, and their application as non-invasive biomarkers. The rapid advances in next-generation omics technologies are the driving forces for these discoveries. In this review, the authors focus on recent results of EV research in ovarian cancer. A deeper understanding of ovarian cancer-derived EVs, the types of cargo molecules and their biological roles in cancer growth, metastases and drug resistance, could have significant impact on the discovery of novel biomarkers and innovative therapeutics. Insights into the role of EVs in immune regulation could lead to novel approaches built on EV-based immunotherapy.
authors.affiliation: a Department of Pathology and Forensic Medicine, Ribeirao Preto School of Medicine , University of Sao Paulo , Sao Paulo , Brazil.|b Department of Rheumatology and Inflammation Research , Sahlgrenska Academy at the University of Gothenburg , Guldhedsgatan Sweden.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Nawaz
authors.affiliation: a Department of Pathology and Forensic Medicine, Ribeirao Preto School of Medicine , University of Sao Paulo , Sao Paulo , Brazil.|b Department of Rheumatology and Inflammation Research , Sahlgrenska Academy at the University of Gothenburg , Guldhedsgatan Sweden.
authors.forename: Farah
authors.initials: F
authors.lastname: Fatima
authors.affiliation: c Institute for Environmental Health Sciences and Hospital Infection Control , University Medical Centre Freiburg , Freiburg im Breisgau , Germany.
authors.forename: Irina
authors.initials: I
authors.lastname: Nazarenko
authors.affiliation: d Department of Biomaterials , Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden.|e BIOMATCELL VINN Excellence Centre of Biomaterials and Cell Therapy , Gothenburg , Sweden.
authors.forename: Karin
authors.initials: K
authors.lastname: Ekström
authors.affiliation: f Department of Biochemistry, Faculty of Biological Sciences , Quaid-i-Azam University Islamabad , Islamabad , Pakistan.
authors.forename: Iram
authors.initials: I
authors.lastname: Murtaza
authors.affiliation: f Department of Biochemistry, Faculty of Biological Sciences , Quaid-i-Azam University Islamabad , Islamabad , Pakistan.
authors.forename: Mariam
authors.initials: M
authors.lastname: Anees
authors.affiliation: f Department of Biochemistry, Faculty of Biological Sciences , Quaid-i-Azam University Islamabad , Islamabad , Pakistan.
authors.forename: Aneesa
authors.initials: A
authors.lastname: Sultan
authors.affiliation: a Department of Pathology and Forensic Medicine, Ribeirao Preto School of Medicine , University of Sao Paulo , Sao Paulo , Brazil.
authors.forename: Luciano
authors.initials: L
authors.lastname: Neder
authors.affiliation: g Department of Medical Sciences and Molecular Biotechnology Centre , University of Torino , Torino , Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Camussi
authors.affiliation: b Department of Rheumatology and Inflammation Research , Sahlgrenska Academy at the University of Gothenburg , Guldhedsgatan Sweden.
authors.forename: Hadi
authors.initials: H
authors.lastname: Valadi
authors.affiliation: a Department of Pathology and Forensic Medicine, Ribeirao Preto School of Medicine , University of Sao Paulo , Sao Paulo , Brazil.
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: Squire
authors.affiliation: h Princess Margaret Cancer Centre and Department of Medical Biophysics , University of Toronto , Toronto , ON , Canada.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kislinger
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000067128:Extracellular Vesicles / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D035683:MicroRNAs / Q000235:genetics; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D040901:Proteomics / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Extracellular vesicles; biomarkers; exosomes; glycoproteins; immunotherapy; matrix metalloproteinase; microRNAs; ovarian cancer