title: [Frailty and long term mortality, disability and hospitalisation in Spanish older adults. The FRADEA Study].
abstract: BACKGROUND
  The objective of this study was to analyse whether frailty is related to long-term mortality, incident disability in basic activities of daily living (BADL), and hospitalisation.
  
  
  METHODS
  A concurrent cohort study conducted on 993 participants over age 70 from the FRADEA Study. Frailty was determined with Fried frailty phenotype. Data was collected on mortality, hospitalisation and incident disability in BADL (bathing, grooming, dressing, toileting, eating or transferring) during the follow-up period. The risk of adverse events was determined by logistic regression, Kaplan-Meier analysis, and Cox proportional hazard analysis adjusted for age, sex, Barthel index, comorbidity and institutionalization.
  
  
  RESULTS
  Mean follow-up was 952 days (SD 408), during which 182 participants (18.4%) died. Frail participants had an increased adjusted risk of death (HR 4.5, 95%CI: 1.8-11.1), incident disability in BADL (OR 2.7, 95%CI: 1.3-5.9) and the combined event mortality or incident disability (OR 3.0, 95%CI: 1.5-6.1). Pre-frail subjects had an increased adjusted risk of death (HR 2.9, 95%CI: 1.2-6.5), incident disability in BADL (OR 2.1, 95%CI: 1.2-3.6), and the combined event mortality or incident disability (OR 2.2, 95%CI: 1.3-3.6). There was a positive association between frailty and hospitalisation, which almost reached statistical significance (OR 1.7, 95%CI: 1.0-3.0).
  
  
  CONCLUSIONS
  Frailty is long-term associated with mortality and incident disability in BADL in a Spanish cohort of older adults.
authors.affiliation: Servicio de Geriatría, Complejo Hospitalario Universitario de Albacete, Albacete, España.
authors.forename: Marta
authors.initials: M
authors.lastname: Martínez-Reig
authors.affiliation: Servicio de Geriatría, Complejo Hospitalario Universitario de Albacete, Albacete, España.
authors.forename: Teresa
authors.initials: T
authors.lastname: Flores Ruano
authors.affiliation: Servicio de Geriatría, Complejo Hospitalario Universitario de Albacete, Albacete, España.
authors.forename: Miguel
authors.initials: M
authors.lastname: Fernández Sánchez
authors.affiliation: Servicio de Geriatría, Complejo Hospitalario Universitario de Albacete, Albacete, España.
authors.forename: Alicia
authors.initials: A
authors.lastname: Noguerón García
authors.affiliation: Servicio de Geriatría, Complejo Hospitalario Universitario de Albacete, Albacete, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Romero Rizos
authors.affiliation: Servicio de Geriatría, Complejo Hospitalario Universitario de Albacete, Albacete, España. Electronic address: pabizanda@sescam.jccm.es.
authors.forename: Pedro
authors.initials: P
authors.lastname: Abizanda Soler
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D016330:Frail Elderly; D000073496:Frailty; D006760:Hospitalization; D006801:Humans; D008297:Male
keywords: Disability; Discapacidad; Estudio FRADEA; FRADEA Study; Fragilidad; Frail elderly; Hospitalisation; Hospitalización; Mortalidad; Mortality