title: Nanoparticle Targeting of Neutrophils for Improved Cancer Immunotherapy.
abstract: Cancer immunotherapy using tumor-specific monoclonal antibodies presents a novel approach for cancer treatment. A monoclonal antibody TA99 specific for gp75 antigen of melanoma initiates neutrophil recruitment in tumor responsible for cancer therapy. Here, a strategy is reported for hijacking neutrophils in vivo using nanoparticles (NPs) to deliver therapeutics into tumor. In a mouse model of melanoma, it is shown that systemically delivered albumin NPs increase in tumor when TA99 antibody is injected; and the NP tumor accumulation is mediated by neutrophils. After the administration of pyropheophorbide-a loaded albumin NPs and TA99, photodynamic therapy significantly suppresses the tumor growth and increases mouse survival compared with treatment with the NPs or TA99. The study reveals a new avenue to treat cancer by NP hitchhiking of immune systems to enhance delivery of therapeutics into tumor sites.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, 99210, USA.
authors.forename: Dafeng
authors.initials: D
authors.lastname: Chu
authors.affiliation: Faculty of Health Sciences, University of Macau, Macau, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, 99210, USA.
authors.forename: Faya
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, 99210, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, 99210, USA.
authors.forename: Zhenjia
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D000074322:Antineoplastic Agents, Immunological / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*; D007167:Immunotherapy; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D020556:Neutrophil Infiltration / Q000187:drug effects* / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*
chemical_list: D000074322:Antineoplastic Agents, Immunological
keywords: albumin nanoparticles; antibodies; immunotherapy; neutrophils; tumor