title: An integrative data analysis platform for gene set analysis and knowledge discovery in a data warehouse framework.
abstract: Data analysis is one of the most critical and challenging steps in drug discovery and disease biology. A user-friendly resource to visualize and analyse high-throughput data provides a powerful medium for both experimental and computational biologists to understand vastly different biological data types and obtain a concise, simplified and meaningful output for better knowledge discovery. We have previously developed TargetMine, an integrated data warehouse optimized for target prioritization. Here we describe how upgraded and newly modelled data types in TargetMine can now survey the wider biological and chemical data space, relevant to drug discovery and development. To enhance the scope of TargetMine from target prioritization to broad-based knowledge discovery, we have also developed a new auxiliary toolkit to assist with data analysis and visualization in TargetMine. This toolkit features interactive data analysis tools to query and analyse the biological data compiled within the TargetMine data warehouse. The enhanced system enables users to discover new hypotheses interactively by performing complicated searches with no programming and obtaining the results in an easy to comprehend output format. Database URL: http://targetmine.mizuguchilab.org.
authors.affiliation: National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan kenji@nibiohn.go.jp.
authors.forename: Yi-An
authors.initials: YA
authors.lastname: Chen
authors.affiliation: National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan kenji@nibiohn.go.jp.
authors.forename: Lokesh P
authors.initials: LP
authors.lastname: Tripathi
authors.affiliation: National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan kenji@nibiohn.go.jp.
authors.forename: Kenji
authors.initials: K
authors.lastname: Mizuguchi
mesh_terms: D019295:Computational Biology / Q000379:methods*; D057225:Data Mining; D030541:Databases, Genetic; D005796:Genes; D020022:Genetic Predisposition to Disease; D006801:Humans; D019359:Knowledge; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D058977:Molecular Sequence Annotation; D060066:Protein Interaction Maps; D013223:Statistics as Topic; D015854:Up-Regulation / Q000235:genetics; D014584:User-Computer Interface
chemical_list: D035683:MicroRNAs