title: Carboxylation of Phenols with CO2 at Atmospheric Pressure.
abstract: A convenient and efficient method for the ortho-carboxylation of phenols under atmospheric CO2 pressure has been developed. This method provides an alternative to the previously reported Kolbe-Schmitt method, which requires very high pressures of CO2 . The addition of a trisubstituted phenol has proved essential for the successful carboxylation of phenols with CO2 at standard atmospheric pressure, allowing the efficient preparation of a broad variety of salicylic acids.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.|School of Biological and Chemical Sciences, Queen Mary University of London, Joseph Priestley Building, Mile End Road, E1 4NS, London, UK.
authors.forename: Junfei
authors.initials: J
authors.lastname: Luo
authors.affiliation: School of Biological and Chemical Sciences, Queen Mary University of London, Joseph Priestley Building, Mile End Road, E1 4NS, London, UK.
authors.forename: Sara
authors.initials: S
authors.lastname: Preciado
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Pan
authors.initials: P
authors.lastname: Xie
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. igor.larrosa@manchester.ac.uk.
authors.forename: Igor
authors.initials: I
authors.lastname: Larrosa
mesh_terms: D001274:Atmospheric Pressure; D002245:Carbon Dioxide / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis*; D003408:Cresols / Q000737:chemistry; D055601:Organic Chemistry Phenomena; D010636:Phenols / Q000737:chemistry*; D012459:Salicylates / Q000138:chemical synthesis*; D017670:Sodium Compounds / Q000737:chemistry; D013696:Temperature
chemical_list: D002264:Carboxylic Acids; D003408:Cresols; D010636:Phenols; D012459:Salicylates; D017670:Sodium Compounds; D002245:Carbon Dioxide; C524957:sodium hydride; C505148:2,4,6-trimethylphenol
keywords: Kolbe-Schmitt reaction; carbon dioxide; phenols; salicylic acids; synthetic methods