title: Assessed value of high-sensitivity cardiac troponin T for cardiovascular disease among CKD patients.
abstract: Objective To analyze the relationship between serum high-sensitivity cardiac troponin T (hs-cTnT) and cardiovascular disease (CVD) among non-dialysis chronic kidney disease (CKD) patients, and to further explore its value of evaluating and predicting CVD in this population. Methods Five hundred and fifty-seven non-dialysis CKD patients were involved in this cross-sectional study. The relationship between serum hs-cTnT and CVD was analyzed using comparison between groups and regression analysis, and its value on assessing cardiac structure and function was evaluated by ROC curves. Results Median level of hs-cTnT was 13 (7-29) ng/L, with 1.7% undetectable, 46.4% greater than 99th percentile of the general population. Multivariate analysis suggested that compared with the lowest quartile of hs-cTnT, the highest quartile was approximately six times as likely to develop into LVH (OR, 6.515; 95% CI, 3.478-12.206, p < 0.05) and 18 times as likely to progress to left ventricular diastolic dysfunction(OR, 18.741; 95% CI, 2.422-145.017, p < 0.05). And Ln cTnT level had a more modest association with LVEF (OR, -1.117; 95% CI, -5.839 to -0.594; p < 0.05). When evaluated as a screening test, the area under the curve of ROC curves for hs-cTnT was 0.718, 0.788 and 0.736, respectively (p < 0.05). With a specificity of 90% as a diagnostic criterion, the value of hs-cTnT to evaluate LVH, LVEF < 50%, left ventricular diastolic dysfunction increased across CKD stages, from CKD 1 stage to CKD 5 stage. Conclusions In CKD non-dialysis population, hs-cTnT and NT-proBNP were valuable for evaluating LVH, left ventricular systolic dysfunction and left ventricular diastolic dysfunction.
authors.affiliation: a Department of Nephrology , the First Affiliated Hospital with Nanjing Medical University , Nanjing , P.R. China ;
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.affiliation: b Department of Nephrology, Shanghai Institute of Kidney and Dialysis , Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University , Shanghai , P.R. China ;
authors.forename: Xiao
authors.initials: X
authors.lastname: Tan
authors.affiliation: c Dialysis Center , Zhongshan Hospital, Fudan University , Shanghai , P.R. China.
authors.forename: Xuesen
authors.initials: X
authors.lastname: Cao
authors.affiliation: c Dialysis Center , Zhongshan Hospital, Fudan University , Shanghai , P.R. China.
authors.forename: Jianzhou
authors.initials: J
authors.lastname: Zou
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D012372:ROC Curve; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications / Q000453:epidemiology; D015203:Reproducibility of Results; D012307:Risk Factors; D013318:Stroke Volume; D020107:Troponin T / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Chronic kidney disease; hs-cTnT; left ventricular diastolic dysfunction; left ventricular hypertrophy; left ventricular systolic dysfunction