title: International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents.
abstract: BACKGROUND
  Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.
  
  
  RESULTS
  Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years). Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86×10(-8)) and rs872256 during puberty (P=8.67×10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at P<5×10(-3). Using a P value threshold of <5×10(-3), we found some overlap in variants across the different age epochs within our study and between several single-nucleotide polymorphisms in any of the 3 epochs and adult BP-related single-nucleotide polymorphisms.
  
  
  CONCLUSIONS
  Our results suggest that genetic determinants of BP act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.
authors.forename: Priyakumari Ganesh
authors.initials: PG
authors.lastname: Parmar
authors.forename: H Rob
authors.initials: HR
authors.lastname: Taal
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Timpson
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Thiering
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: Marcella
authors.initials: M
authors.lastname: Marinelli
authors.forename: Penelope A
authors.initials: PA
authors.lastname: Lind
authors.forename: Laura D
authors.initials: LD
authors.lastname: Howe
authors.forename: Germaine
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authors.lastname: Verwoert
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authors.initials: V
authors.lastname: Aalto
authors.forename: Andre G
authors.initials: AG
authors.lastname: Uitterlinden
authors.forename: Laurent
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authors.lastname: Briollais
authors.forename: Dave M
authors.initials: DM
authors.lastname: Evans
authors.forename: Margie J
authors.initials: MJ
authors.lastname: Wright
authors.forename: John P
authors.initials: JP
authors.lastname: Newnham
authors.forename: John B
authors.initials: JB
authors.lastname: Whitfield
authors.forename: Leo-Pekka
authors.initials: LP
authors.lastname: Lyytikäinen
authors.forename: Fernando
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authors.lastname: Rivadeneira
authors.forename: Dorrett I
authors.initials: DI
authors.lastname: Boomsma
authors.forename: Jorma
authors.initials: J
authors.lastname: Viikari
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Gillman
authors.forename: Beate
authors.initials: B
authors.lastname: St Pourcain
authors.forename: Jouke-Jan
authors.initials: JJ
authors.lastname: Hottenga
authors.forename: Grant W
authors.initials: GW
authors.lastname: Montgomery
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.forename: Martin D
authors.initials: MD
authors.lastname: Tobin
authors.forename: Ollie
authors.initials: O
authors.lastname: Raitakari
authors.forename: Jesus
authors.initials: J
authors.lastname: Vioque
authors.forename: Vincent W V
authors.initials: VWV
authors.lastname: Jaddoe
authors.forename: Marjo-Riita
authors.initials: MR
authors.lastname: Jarvelin
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Beilin
authors.forename: Joachim
authors.initials: J
authors.lastname: Heinrich
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: Craig E
authors.initials: CE
authors.lastname: Pennell
authors.forename: Debbie A
authors.initials: DA
authors.lastname: Lawlor
authors.forename: Lyle J
authors.initials: LJ
authors.lastname: Palmer
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001794:Blood Pressure / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D056426:Genetic Loci; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D039001:Integrin alpha Chains / Q000235:genetics*; D008297:Male; D017720:Molecular Epidemiology; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: D005819:Genetic Markers; C121535:ITGA11 protein, human; D039001:Integrin alpha Chains
keywords: Genome-Wide Association Study; blood pressure; children; genetic epidemiology; hypertension; prehypertension