title: Extension of Drosophila Lifespan by Rhodiola rosea Depends on Dietary Carbohydrate and Caloric Content in a Simplified Diet.
abstract: The root and rhizome extract of Rhodiola rosea has been extensively used in traditional medicine to improve physical and mental performance and to protect against stress. We, and others, have reported that R. rosea can extend lifespan in flies, worms, and yeast. We also previously found that the extract can act independently of dietary restriction (DR), a treatment that can extend lifespan in a range of model organisms. In flies, DR is implemented through a reduction in dietary yeast content. Here, we report that the ability of R. rosea extract to extend lifespan in flies is dependent on the carbohydrate and caloric content when supplemented with a simplified diet composed of yeast and sucrose. R. rosea extract elevated the sugar content in flies and down-regulated hexokinase expression, suggesting that it perturbs carbohydrate metabolism in flies. In our previous studies, bananas, barley malt, and corn syrup provided dietary carbohydrates, and R. rosea extract could extend lifespan with a range of caloric levels. We conclude that the lifespan-extending effect of R. rosea extract in flies is dependent on dietary carbohydrate and caloric contents coupled with an interaction with complex dietary components present in bananas, barley, or corn.
authors.affiliation: Department of Pharmaceutical Sciences, University of California Irvine , Irvine, California.
authors.forename: Samuel E
authors.initials: SE
authors.lastname: Schriner
authors.affiliation: Department of Pharmaceutical Sciences, University of California Irvine , Irvine, California.
authors.forename: Volkan
authors.initials: V
authors.lastname: Coskun
authors.affiliation: Department of Pharmaceutical Sciences, University of California Irvine , Irvine, California.
authors.forename: Sean P
authors.initials: SP
authors.lastname: Hogan
authors.affiliation: Department of Pharmaceutical Sciences, University of California Irvine , Irvine, California.
authors.forename: Cindy T
authors.initials: CT
authors.lastname: Nguyen
authors.affiliation: Department of Pharmaceutical Sciences, University of California Irvine , Irvine, California.
authors.forename: Terry E
authors.initials: TE
authors.lastname: Lopez
authors.affiliation: Department of Pharmaceutical Sciences, University of California Irvine , Irvine, California.
authors.forename: Mahtab
authors.initials: M
authors.lastname: Jafari
mesh_terms: D000818:Animals; D004040:Dietary Carbohydrates / Q000032:analysis / Q000378:metabolism*; D004330:Drosophila; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000378:metabolism; D002149:Energy Intake; D005260:Female; D006801:Humans; D008136:Longevity / Q000187:drug effects*; D008297:Male; D023421:Models, Animal; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D029771:Rhodiola / Q000737:chemistry*
chemical_list: D004040:Dietary Carbohydrates; D010936:Plant Extracts
keywords: Rhodiola rosea; aging; botanical extract; dietary restriction; lifespan