title: The use of recombinant morphogenic protein-2(rhBMP-2) in children undergoing revision surgery for persistent non-union.
abstract: The purpose of the study was to evaluate the safety and efficacy with the use of BMP-2 for treating persistent non-unions in children with underlying complex conditions. Between October 2006 and November 2010 in our unit, 15 patients were treated with rhBMP-2 to enhance bone union. There were nine females and six males with a mean age of 9.5 years (range 4-15) at time of surgery. Seventy-five per cent of the patients required revision of internal fixation with insertion of rhBMP-2 to the non-union site, and the reminder had freshening of the non-union site with rhBMP-2 application. Patients had undergone a mean of 2 (1-5) operations prior to implantation of rhBMP-2. All the patients in the study group were available for review with mean follow-up of 44 months (range 21-70). The mean time to union was 16 weeks (range 10-28 weeks). No adverse events related to BMP-2 application were noted in our study group. Healing occurred clinically and radiographically in 16 of the 17 sites. Our study demonstrates that BMP-2 enhances healing of the persistent non-unions without any adverse events.
authors.affiliation: Department of Trauma and Orthopaedics, Sheffield Children Hospital, Sheffield, S10 2TH, UK. drmadhavan@hotmail.com.
authors.forename: Madhavan C
authors.initials: MC
authors.lastname: Papanna
authors.affiliation: Department of Trauma and Orthopaedics, Sheffield Children Hospital, Sheffield, S10 2TH, UK.
authors.forename: K A
authors.initials: KA
authors.lastname: Saldanha
authors.affiliation: Department of Trauma and Orthopaedics, Sheffield Children Hospital, Sheffield, S10 2TH, UK.
authors.forename: Binu
authors.initials: B
authors.lastname: Kurian
authors.affiliation: Department of Trauma and Orthopaedics, Sheffield Children Hospital, Sheffield, S10 2TH, UK.
authors.forename: James A
authors.initials: JA
authors.lastname: Fernandes
authors.affiliation: Department of Trauma and Orthopaedics, Sheffield Children Hospital, Sheffield, S10 2TH, UK.
authors.forename: Stan
authors.initials: S
authors.lastname: Jones
keywords: Bone; Congenital abnormalities non-union; rhBMP-2