title: Production of virulence factors in Candida strains isolated from patients with denture stomatitis and control individuals.
abstract: The aim of this study was to evaluate the production of virulence factors in Candida isolates from the oral cavities of 50 patients with different degrees of denture stomatitis (DS, type I, II and III) and 50 individuals without signs of DS. We evaluated the enzymatic and hemolytic activities, the biofilm formation, and the cell surface hydrophobicity (CSH) in all isolates. Germ tube (GT) production was also evaluated in Candida albicans and Candida dubliniensis isolates. In C. albicans and C. dubliniensis the secretion of hemolysin and GT production was significantly different between isolates from patients with DS and individuals without DS. No significant difference was observed in the production of virulence factors by Candida glabrata isolates. Candida isolates expressed a wide range of virulence factors. However, in the majority of isolates from the type III lesions, the production of the virulence factors was higher than for the other groups.
authors.affiliation: Institute of Science and Technology, UNESP, Univ Estadual Paulista, Francisco José Longo 777, São Dimas, São José dos Campos, CEP: 12245-000, SP, Brazil. Electronic address: cricabio@gmail.com.
authors.forename: Cristiane Aparecida
authors.initials: CA
authors.lastname: Pereira
authors.affiliation: Institute of Science and Technology, UNESP, Univ Estadual Paulista, Francisco José Longo 777, São Dimas, São José dos Campos, CEP: 12245-000, SP, Brazil. Electronic address: nadiamfe@yahoo.com.br.
authors.forename: Nádia
authors.initials: N
authors.lastname: Domingues
authors.affiliation: Institute of Science and Technology, UNESP, Univ Estadual Paulista, Francisco José Longo 777, São Dimas, São José dos Campos, CEP: 12245-000, SP, Brazil. Electronic address: mariaizabeldaniel@hotmail.com.
authors.forename: Maria Izabel Daniel Santos Alves
authors.initials: MI
authors.lastname: Araújo
authors.affiliation: Institute of Science and Technology, UNESP, Univ Estadual Paulista, Francisco José Longo 777, São Dimas, São José dos Campos, CEP: 12245-000, SP, Brazil. Electronic address: juliana@fosjc.unesp.br.
authors.forename: Juliana Campos
authors.initials: JC
authors.lastname: Junqueira
authors.affiliation: Institute of Science and Technology, UNESP, Univ Estadual Paulista, Francisco José Longo 777, São Dimas, São José dos Campos, CEP: 12245-000, SP, Brazil. Electronic address: graziella.back@ict.unesp.br.
authors.forename: Graziella Nuernberg
authors.initials: GN
authors.lastname: Back-Brito
authors.affiliation: Institute of Science and Technology, UNESP, Univ Estadual Paulista, Francisco José Longo 777, São Dimas, São José dos Campos, CEP: 12245-000, SP, Brazil. Electronic address: olavojorge@fosjc.unesp.br.
authors.forename: Antonio Olavo Cardoso
authors.initials: AO
authors.lastname: Jorge
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018441:Biofilms; D002175:Candida / Q000302:isolation & purification* / Q000472:pathogenicity / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D006461:Hemolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013282:Stomatitis, Denture / Q000175:diagnosis* / Q000382:microbiology*; D037521:Virulence Factors / Q000235:genetics
chemical_list: D037521:Virulence Factors
keywords: Candida; Denture stomatitis; Virulence factors