title: Acinetobacter baumannii Infection and IL-17 Mediated Immunity.
abstract: Acinetobacter baumannii is a significant cause of severe hospital-acquired infections with a recent rise in multidrug-resistant infections involving traumatic wounds of military personnel. The interleukin-17 (IL-17) pathway is essential for neutrophil recruitment in response to a variety of pathogens, while the control of A. baumannii infection is known to be dependent on neutrophils. This suggests that IL-17 may play an important role in A. baumannii infection; however, this has yet to be studied. Here, we summarize the recent advances in understanding the host-pathogen interaction of A. baumannii and propose a potential role of the IL-17 pathway in generating a protective immune response.
authors.affiliation: Department of Clinical Laboratory, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu 214002, China.
authors.forename: Zihe
authors.initials: Z
authors.lastname: Yan
authors.affiliation: Department of Clinical Laboratory, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu 214002, China.
authors.forename: Junjun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Clinical Laboratory, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu 214002, China.
authors.forename: Renjing
authors.initials: R
authors.lastname: Hu
authors.affiliation: Department of Clinical Laboratory, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu 214002, China.
authors.forename: Xichi
authors.initials: X
authors.lastname: Hu
authors.affiliation: Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.
authors.forename: Kong
authors.initials: K
authors.lastname: Chen
mesh_terms: D040981:Acinetobacter baumannii / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D008168:Lung / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D058504:Th17 Cells / Q000378:metabolism
chemical_list: D020381:Interleukin-17