title: Paroxetine: An update of response on intestinal motility.
abstract: OBJECTIVE
  To find out the possible effects of paroxetine on gastrointestinal smooth muscles in vitro as they can cause severe nausea and vomiting at the start of therapy which later settles down.
  
  
  METHODS
  Power lab (USA) was used for recording the contractions of ileal smooth muscle of rabbits in response to acetylcholine, serotonin and paroxetine.
  
  
  RESULTS
  The percent responses with acetylcholine, serotonin and paroxetine were 100, 158.7 and 6.45 percent respectively indicating that acetylcholine and serotonin causes an increase in contractility of isolated ileal smooth muscle in comparison to paroxetine which has a depressant effect on motility.
  
  
  CONCLUSIONS
  Inability of paroxetine to enhance the serotonergic transmission in vitro causes a decrease in its qualitative response.
authors.affiliation: Department of Pharmacology, Wah Medical College, Wah Cantt, Pakistan.
authors.forename: Ayesha
authors.initials: A
authors.lastname: Afzal
authors.affiliation: Department of Pharmacology, Wah Medical College, Wah Cantt, Pakistan.
authors.forename: Khalida
authors.initials: K
authors.lastname: Ajmal
authors.affiliation: Department of Pharmacology, Rawal Medical College, Rawalpindi, Pakistan.
authors.forename: Sabeen
authors.initials: S
authors.lastname: Shakir
authors.affiliation: Department of Pharmacology, Army Medical College, Rawalpindi, Pakistan.
authors.forename: Bushra Tayabba
authors.initials: BT
authors.lastname: Khan
authors.affiliation: Department of Pharmacology, Wah Medical College, Wah Cantt, Pakistan.
authors.forename: Iffat
authors.initials: I
authors.lastname: Ara
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D018679:Cholinergic Agonists / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007082:Ileum / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D017374:Paroxetine / Q000494:pharmacology*; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
chemical_list: D000109:Acetylcholine; D018679:Cholinergic Agonists; D017374:Paroxetine; D012701:Serotonin; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Serotonin, Paroxetine, Acetylcholine, Gastrointestinal tract, Diarrhea, Power lab.