title: The Effects of Phrenic Nerve Degeneration by Axotomy and Crush on the Electrical Activities of Diaphragm Muscles of Rats.
abstract: The aim of this study was to investigate the effect of axotomy and crush-related degeneration on the electrical activities of diaphragm muscle strips of experimental rats. In the present study, twenty-one male Wistar-albino rats were used and divided into three groups. The animals in the first group were not crushed or axotomized and served as controls. Phrenic nerves of the rats in the second and third groups were crushed or axotomized in the diaphragm muscle. Resting membrane potential (RMP) was decreased significantly in both crush and axotomy of diaphragm muscle strips of experimental rats (p < 0.05). Depolarization time (T DEP) and half-repolarization (1/2 RT) time were significantly prolonged in crush and axotomy rats (p < 0.05). Crushing or axotomizing the phrenic nerves may produce electrical activities in the diaphragm muscle of the rat by depolarization time and half-repolarization time prolonged in crush and axotomy rats.
authors.affiliation: Vocational College Technical Programmes, Muş Alparslan University, Muş, Turkey. esref_alkis@hotmail.com.
authors.forename: Mehmet Eşref
authors.initials: ME
authors.lastname: Alkiş
authors.affiliation: Department of Biophysics, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Turkey.
authors.forename: Servet
authors.initials: S
authors.lastname: Kavak
authors.affiliation: Department of Thoracic Surgery, Faculty of Medicine, Yüzüncü Yıl University, Van, Turkey.
authors.forename: Fuat
authors.initials: F
authors.lastname: Sayır
authors.affiliation: Department of Biophysics, Ondokuzmayis University, Medical School, Samsun, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Him
mesh_terms: D000818:Animals; D003964:Diaphragm / Q000294:innervation* / Q000502:physiology; D019054:Evoked Potentials, Motor; D008297:Male; D009410:Nerve Degeneration / Q000503:physiopathology*; D010791:Phrenic Nerve / Q000502:physiology* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar
keywords: Diaphragm muscle; Electro-biophysics; Phrenic nerves; Rats