title: Maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility.
abstract: Photoactive molecules with the frameworks of chlorin and/or porphyrin possessing four perfluorinated aromatic rings were conjugated with maltotriose (Mal3) via the nucleophilic aromatic substitution reaction and subsequent deprotection reaction of the oligosaccharide moieties. The resulting oligosaccharide-conjugated molecules are ultimately improved as compared to the previously reported monosaccharide-counterparts in terms of water-solubility. In particular, a water-soluble chlorin derivative surrounded by four Mal3 molecules showed an excellent biocompatibility, strong photoabsorption in the longer wavelength regions, and a very high photocytotoxicity. Thus, the present synthetic route combined with the use of an oligosaccharide was shown to be a straightforward strategy to develop a third generation photosensitizer for photodynamic therapy (PDT).
authors.affiliation: Department of Polymer Science and Engineering, Graduate School of Science and Engineering, Yamagata University, Jonan 4-3-16, Yonezawa 992-8510, Japan. narumi@yz.yamagata-u.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Narumi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsuji
authors.forename: Kosuke
authors.initials: K
authors.lastname: Shinohara
authors.forename: Hiromi
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Moriya
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Seigou
authors.initials: S
authors.lastname: Kawaguchi
authors.forename: Tomoya
authors.initials: T
authors.lastname: Mae
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ikeda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sakai
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kataoka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Inoue
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nomoto
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kikuchi
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Yano