title: Effects of percutaneous transhepatic interventional treatment for symptomatic Budd-Chiari syndrome secondary to hepatic venous obstruction.
abstract: OBJECTIVE
  Budd-Chiari syndrome (BCS) is a rare and life-threatening disorder characterized by hepatic venous outflow obstruction. The management of BCS includes anticoagulation and thrombolysis, percutaneous transhepatic stent angioplasty (PTSA), and transjugular intrahepatic portosystemic shunt (TIPS), but the effect of these approaches varies greatly. The aim of our study was to retrospectively evaluate the medium-term effects of PTSA and TIPS of BCS secondary to hepatic venous outflow obstruction and to determine the critical factors affecting the efficacy.
  
  
  METHODS
  From June 2007 to June 2012, 18 patients (15 males and 3 females; mean age, 36 ± 9 years) with BCS (obstruction of the hepatic veins) treated by PTSA (n = 15) and TIPS (n = 3) were studied retrospectively. Clinical records were analyzed with respect to underlying disease, therapeutic interventions, complications, quality of life, and overall outcome.
  
  
  RESULTS
  Percutaneous transhepatic interventional treatment was technically successful in all patients. In PTSA group, the primary and secondary stent patency rates were 80% and 86.7%, respectively. In the TIPS group, ascites resolved completely, and liver congestion and function were relieved greatly in all three patients. Hemodynamic features and clinical symptoms in patients with successful treatment improved significantly. Physical aspects evaluated by SF-36 were improved greatly at the end of follow-up.
  
  
  CONCLUSIONS
  For segmental stenosis or occlusion of hepatic vein caused by thrombosis or membranous webs, PTSA should be recommended as the first choice. TIPS should be applied for diffuse stenosis or occlusion in all the hepatic veins and branches. Standard anticoagulation may promote stent patency. Quality of life after interventional treatment was improved partially, and the mental aspects need to be further investigated.
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Department of Radiology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Zai-Bo
authors.initials: ZB
authors.lastname: Jiang
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Ming-Sheng
authors.initials: MS
authors.lastname: Huang
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Kang-Shun
authors.initials: KS
authors.lastname: Zhu
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Jie-Sheng
authors.initials: JS
authors.lastname: Qian
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Interventional Radiology Institute of Sun Yat-sen University, Guangzhou, China. Electronic address: shanhong@mail.sysu.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Shan