title: Assuring the Proper Analytical Performance of Measurement Procedures for Immunosuppressive Drug Concentrations in Clinical Practice: Recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Immunosuppressive Drug Scientific Committee.
abstract: Monitoring immunosuppressive drugs (ISDs) in blood or plasma is still a key therapeutic drug monitoring (TDM) application in clinical settings. Narrow target ranges and severe side effects at drug underexposure or overexposure make accurate and precise measurements a must. This overview prepared by the Immunosuppressive Drugs Scientific Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology is intended to serve as a summary and guidance document describing the current state-of-the-art in the TDM of ISDs.
authors.affiliation: *Risch Laboratories Group, Schaan, Principality of Liechtenstein; †Klinikum Stuttgart, Zentralinstitut für Klinische Chemie und Laboratoriumsmedizin, Stuttgart, Germany; ‡iC42 Clinical Research and Development, University of Colorado, Anschutz Medical Campus, Denver; §Pharmacology, APHP, Hôpital Européen G Pompidou, Paris Descartes University, France; ¶Department of Pathology and Genomic Medicine, Houston Methodist Hospital, TX; ‖ASI Ltd, St George's-University of London, United Kingdom; **Pharmacology and Toxicology Laboratory, Biomedical Diagnostic Center (CDB), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain; ††Clinical Pharmacology Unit, Institute of Cardiology, Medical University of Warsaw, Poland; ‡‡Department of Drug Chemistry, Medical University of Warsaw, Poland; §§Department of Laboratory Medicine and Pathology, Mayo Clinic, College of Medicine, Rochester, NY; ¶¶UMR 850 INSERM, University Limoges, CHU Limoges, France; ‖‖Department of Clinical Pharmacology, Georg-August University, University Medical Center Göttingen, Germany; and ***Clinical Chemistry Department, Université Catholique de Louvain, LTAP, Cliniques Universitaires St Luc, Brussels, Belgium.
authors.forename: Christoph
authors.initials: C
authors.lastname: Seger
authors.forename: Maria
authors.initials: M
authors.lastname: Shipkova
authors.forename: Uwe
authors.initials: U
authors.lastname: Christians
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Billaud
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: David W
authors.initials: DW
authors.lastname: Holt
authors.forename: Mercè
authors.initials: M
authors.lastname: Brunet
authors.forename: Paweł K
authors.initials: PK
authors.lastname: Kunicki
authors.forename: Thomasz
authors.initials: T
authors.lastname: Pawiński
authors.forename: Loralie J
authors.initials: LJ
authors.lastname: Langman
authors.forename: Pierre
authors.initials: P
authors.lastname: Marquet
authors.forename: Michael
authors.initials: M
authors.lastname: Oellerich
authors.forename: Eberhard
authors.initials: E
authors.lastname: Wieland
authors.forename: Pierre
authors.initials: P
authors.lastname: Wallemacq
mesh_terms: D016903:Drug Monitoring; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood* / Q000493:pharmacokinetics*
chemical_list: D007166:Immunosuppressive Agents