title: Overview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery.
abstract: Many animal models have been developed to investigate the sources of central nervous system (CNS) tumor heterogeneity. Reviewed in this unit is a recently developed CNS tumor model using the piggyBac transposon system delivered by in utero electroporation, in which sources of tumor heterogeneity can be conveniently studied. Their applications for studying CNS tumors and drug discovery are also reviewed. © 2016 by John Wiley & Sons, Inc.
authors.affiliation: Department of Physiology and Neurobiology, University of Connecticut, Storrs, Conn.|Current address: Department of Neurology, Yale School of Medicine, New Haven, Conn.
authors.forename: Fuyi
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.
authors.forename: Albert
authors.initials: A
authors.lastname: Becker
authors.affiliation: Department of Physiology and Neurobiology, University of Connecticut, Storrs, Conn.
authors.forename: Joseph
authors.initials: J
authors.lastname: LoTurco
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001254:Astrocytoma / Q000188:drug therapy*; D002490:Central Nervous System / Q000187:drug effects*; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods*; D005909:Glioblastoma / Q000188:drug therapy*; D017208:Rats, Wistar
keywords: anaplastic oligoastrocytoma; atypical teratoid rhabdoid tumor; central nervous system; glioblastoma multiforme; in utero electroporation; piggyBac transposon; tumor heterogeneity