title: Pathway analysis of whole exome sequence data provides further support for the involvement of histone modification in the aetiology of schizophrenia.
abstract: Weighted burden pathway analysis was applied to whole exome sequence data for 2045 schizophrenic patients and 2045 controls. Overall, there was a statistically significant excess of pathways with more rare, functional variants in cases than in controls. Among the highest ranked were pathways relating to histone modification, as well as neuron differentiation and membrane and vesicle function. This bolsters the evidence from previous studies that histone modification pathways may be important in the aetiology of schizophrenia.
authors.affiliation: UCL Genetics Institute, University College London, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Curtis
mesh_terms: D016022:Case-Control Studies; D059472:Exome; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D042421:Histone Code; D006657:Histones / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism; D017422:Sequence Analysis, DNA
chemical_list: D006657:Histones