title: Targeting glucose metabolism in cancer: new class of agents for loco-regional and systemic therapy of liver cancer and beyond?
abstract: Hepatocellular carcinoma (HCC) is one of the most prevalent cancers and the third leading cause of cancer-related deaths worldwide. In patients with unresectable disease, loco-regional catheter-based intra-arterial therapies (IAT) can achieve selective tumor control while minimizing systemic toxicity. As molecular features of tumor growth and microenvironment are better understood, new targets arise for selective anticancer therapy. Particularly, antiglycolytic drugs that exploit the hyperglycolytic cancer cell metabolism - also known as the 'Warburg effect' - have emerged as promising therapeutic options. Thus, future developments will combine the selective character of loco-regional drug delivery platforms with highly specific molecular targeted antiglycolytic agents. This review will exemplify literature on antiglycolytic approaches and particularly focus on intra-arterial delivery methods.
authors.affiliation: Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, US; Department of Diagnostic & Interventional Radiology, Universitätsmedizin Charité Berlin, Berlin, Germany.
authors.forename: Lynn Jeanette
authors.initials: LJ
authors.lastname: Savic
authors.affiliation: Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, US; Department of Diagnostic & Interventional Radiology, Universitätsmedizin Charité Berlin, Berlin, Germany.
authors.forename: Julius
authors.initials: J
authors.lastname: Chapiro
authors.affiliation: Department of Diagnostic & Interventional Radiology, Universitätsmedizin Charité Berlin, Berlin, Germany.
authors.forename: Gregor
authors.initials: G
authors.lastname: Duwe
authors.affiliation: Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, US.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Geschwind