title: Serum Klotho Levels in Trained Athletes.
abstract: BACKGROUND
  Klotho is an anti-aging protein that is predominantly secreted by the kidneys.
  
  
  OBJECTIVE
  The aim of the study was to measure and compare the circulating Klotho levels in the serum of trained athletes and in healthy, non-athlete controls.
  
  
  METHODS
  Thirty trained football players were enrolled and their serum Klotho levels were measured the morning after their last evening exercise training.
  
  
  RESULTS
  The plasma free Klotho concentration was significantly higher in the athlete group (3.375 ± 1.48 ng/mL) compared to the non-athletes (1.39 ± 0.43 ng/mL) (P < 0.05). Serum levels of cholesterol, triglycerides, calcium, and phosphorus were not significantly different between the two groups.
  
  
  CONCLUSIONS
  Regular aerobic exercise could increase plasma Klotho levels, and this could be an explanation for exercise-related anti-aging effects.
authors.affiliation: Department of Pathology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, IR Iran; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors.forename: Elmira
authors.initials: E
authors.lastname: Mostafidi
authors.affiliation: Faculty of Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, IR Iran.
authors.forename: Akbar
authors.initials: A
authors.lastname: Moeen
authors.affiliation: Department of Nephrology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, IR Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Nasri
authors.affiliation: Department of Biochemistery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Ghorbani Hagjo
authors.affiliation: Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Ardalan
keywords: Aging; Exercise; Kidney; Serum Klotho