title: Olanzapine as medication of first choice in therapy-resistant schizophrenia?
abstract: A case history of a thirty-one year old schizophrenic female who was treated with olanzapine is described. Olanzapine is a relatively new atypical antipsychotic drug with a dopamine antagonistic as well as a potent serotonine antagonistic effect. Olanzapine was prescribed effectively after haloperidol, flupentixol chloride, and clozapine had not lead to (lasting) improvements of the psychiatric condition of the patient. Considering the efficacy and the limited risks of this relatively new antipsychotic medication the question arises as to whether olanzapine should be considered as the drug of first choice for patients who do not benefit from treatment with a typical neuroleptic drug.
authors.affiliation: *Psychiatric Hospital Welterhof,Heerlen,The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: À Campo
authors.affiliation: *Psychiatric Hospital Welterhof,Heerlen,The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Nijman
authors.affiliation: **Department of Psychology,Maastricht University,Maastricht,The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Merckelbach