title: Anti-Saccharomyces cerevisiae antibodies (ASCA) in spondyloarthritis: Prevalence and associated phenotype.
abstract: OBJECTIVE
  The aim of the study was to compare the prevalence of ASCA in spondyloarthrites (SpA) patients and to investigate the association between ASCA status and disease phenotype.
  
  
  METHODS
  We performed a case-control study including SpA individuals fulfilling the ESSG SpA criteria. The following data were collected for analysis: gender, age, disease duration, clinical or associated features of SpA, treatments, HLAB27 and ASCA status. A control group of patients without SpA was also analyzed.
  
  
  RESULTS
  A total of 235 patients with SpA and 54 control patients were studied. The median age of SpA patients (53.6% of male patients, 52.2% of HLAB27) was 46.0 [IQR 35.0-57.0] years old. Disease duration was 60.0 [IQR 24.0-156.0] months. Inflammatory bowel diseases were observed in 11% of SpA patients. ASCA positivity was significantly higher in SpA patients than in control patients (25.5% [95% CI 20.1-31.6] (IgG: 9.8%; IgA: 21.7%) vs. 7.4% [95% CI 2.1-17.9], P=0.004). Multivariate analysis revealed that ASCA positivity was associated with peripheral involvement (OR: 3.30 [1.26-8.62], P=0.015), presence of IBD (OR: 3.43 [1.15-10.20], P=0.026), past of present history of uveitis (OR: 4.36 [1.08-17.64], P=0.039) and arthritis (OR: 3.78 [1.57-9.15], P=0.003).
  
  
  CONCLUSIONS
  Our results provided evidence that SpA patients had an increased prevalence of ASCA and that ASCA positivity might be associated with a particular phenotype, notably peripheral involvement and uveitis.
authors.affiliation: Service de rhumatologie, hôpital Bichat-Claude-Bernard, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75205 Paris cedex 13, France. Electronic address: philippe.dieude@bch.aphp.fr.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Maillet
authors.affiliation: Service de rhumatologie, hôpital Bichat-Claude-Bernard, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75205 Paris cedex 13, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Ottaviani
authors.affiliation: Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75205 Paris cedex 13, France; Département d'épidémiologie biostatistique et recherche clinique, Inserm CIC-EC 1425, hôpital Bichat-Claude-Bernard, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Tubach
authors.affiliation: Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75205 Paris cedex 13, France; Département d'épidémiologie biostatistique et recherche clinique, Inserm CIC-EC 1425, hôpital Bichat-Claude-Bernard, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France.
authors.forename: Carine
authors.initials: C
authors.lastname: Roy
authors.affiliation: Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75205 Paris cedex 13, France; Service d'immunologie, hôpital Bichat-Claude-Bernard, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Nicaise-Rolland
authors.affiliation: Service de rhumatologie, hôpital Bichat-Claude-Bernard, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75205 Paris cedex 13, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Palazzo
authors.affiliation: Service de rhumatologie, hôpital Bichat-Claude-Bernard, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75205 Paris cedex 13, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Dieudé
mesh_terms: D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis* / Q000276:immunology*; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D016001:Confidence Intervals; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment; D012441:Saccharomyces cerevisiae / Q000276:immunology*; D012720:Severity of Illness Index; D025241:Spondylarthritis / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D015415:Biomarkers
keywords: ASCA; Phenotype; Spondyloarthritis