title: Desmoglein 4 diversity and correlation analysis with coat color in goat.
abstract: Desmoglein 4 (DSG4) has an important role in the development of wool traits in domestic animals. The full-length DSG4 gene, which contains 3918 bp, a complete open-reading-frame, and encodes a 1040-amino acid protein, was amplified from Liaoning cashmere goat. The sequence was compared with that of DSG4 from other animals and the results show that the DSG4 coding region is consistent with interspecies conservation. Thirteen single-nucleotide polymorphisms (SNPs) were identified in a highly variable region of DSG4, and one SNP (M-1, G>T) was significantly correlated with white and black coat color in goat. Haplotype distribution of the highly variable region of DSG4 was assessed in 179 individuals from seven goat breeds to investigate its association with coat color and its differentiation among populations. However, the lack of a signature result indicates DGS4 haplotypes related with the color of goat coat.
authors.affiliation: Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: G X
authors.initials: GX
authors.lastname: E
authors.affiliation: Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Zhao
authors.affiliation: Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Ma
authors.affiliation: College of Agriculture, Liaocheng University, Liaocheng, China.
authors.forename: G L
authors.initials: GL
authors.lastname: Cao
authors.affiliation: College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China.
authors.forename: J N
authors.initials: JN
authors.lastname: He
authors.affiliation: Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: R S
authors.initials: RS
authors.lastname: Na
authors.affiliation: Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Zhao
authors.affiliation: Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: C D
authors.initials: CD
authors.lastname: Jiang
authors.affiliation: Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: J H
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: Department of Psychosomatic Medicine, Inner Mongolia International Mongolian Hospital, Hohhot, China.
authors.forename: S
authors.initials: S
authors.lastname: Arlvd
authors.affiliation: Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: L P
authors.initials: LP
authors.lastname: Chen
authors.affiliation: Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Qiu
authors.affiliation: Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: W
authors.initials: W
authors.lastname: Hu
authors.affiliation: Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: Y F
authors.initials: YF
authors.lastname: Huang
mesh_terms: D000818:Animals; D051182:Desmogleins / Q000235:genetics*; D006041:Goats / Q000235:genetics / Q000378:metabolism*; D006200:Hair Color / Q000235:genetics*; D006239:Haplotypes; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D017423:Sequence Analysis, RNA
chemical_list: D051182:Desmogleins