title: [Correlation between red blood cell count and liver function status].
abstract: OBJECTIVE
  To investigate the changes in red blood cell count in patients with different liver diseases and the correlation between red blood cell count and degree of liver damage.
  
  
  METHODS
  The clinical data of 1427 patients with primary liver cancer, 172 patients with liver cirrhosis, and 185 patients with hepatitis were collected, and the Child-Pugh class was determined for all patients. The differences in red blood cell count between patients with different liver diseases were retrospectively analyzed, and the correlation between red blood cell count and liver function status was investigated. The Mann-Whitney U test, Kruskal-Wallis H test, rank sum test, Spearman rank sum correlation test, and chi-square test were performed for different types of data.
  
  
  RESULTS
  Red blood cell count showed significant differences between patients with chronic hepatitis, liver cancer, and liver cirrhosis and was highest in patients with chronic hepatitis and lowest in patients with liver cirrhosis (P < 0.05). In the patients with liver cirrhosis, red blood cell count tended to decrease in patients with a higher Child-Pugh class (P < 0.05).
  
  
  CONCLUSIONS
  For patients with liver cirrhosis, red blood cell count can reflect the degree of liver damage, which may contribute to an improved liver function prediction model for these patients.
authors.affiliation: College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Leijie
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Mingjie
authors.initials: M
authors.lastname: Yao
authors.forename: Xiajie
authors.initials: X
authors.lastname: Wen
authors.affiliation: Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Xiangmei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Hong
authors.initials: H
authors.lastname: You
authors.affiliation: Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Jidong
authors.initials: J
authors.lastname: Jia
authors.affiliation: Department of Pathological Diagnosis and Research Center, The 302 Hospital of PLA, Beijing 100039, China.
authors.forename: Jingmin
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Fengmin
authors.initials: F
authors.lastname: Lu
mesh_terms: D004906:Erythrocyte Count; D006505:Hepatitis / Q000097:blood*; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood*; D012189:Retrospective Studies