title: A common NTRK2 variant is associated with emotional arousal and brain white-matter integrity in healthy young subjects.
abstract: Dysregulation of emotional arousal is observed in many psychiatric diseases such as schizophrenia, mood and anxiety disorders. The neurotrophic tyrosine kinase receptor type 2 gene (NTRK2) has been associated with these disorders. Here we investigated the relation between genetic variability of NTRK2 and emotional arousal in healthy young subjects in two independent samples (n1=1171; n2=707). In addition, diffusion tensor imaging (DTI) data in a subgroup of 342 participants were used to identify NTRK2-related white-matter structure differences. After correction for multiple testing, we identified a NTRK2 single nucleotide polymorphism associated with emotional arousal in both samples (n1: Pnominal=0.0003, Pcorrected=0.048; n2: Pnominal=0.0141, Pcorrected=0.036). DTI revealed significant, whole-brain corrected correlations between emotional arousal and brain white-matter mean diffusivity (MD), as well as significant, whole-brain corrected NTRK2 genotype-related differences in MD (PFWE<0.05). Our study demonstrates that genetic variability of NTRK2, a susceptibility gene for psychiatric disorders, is related to emotional arousal and-independently-to brain white-matter properties in healthy individuals.
authors.affiliation: Division of Cognitive Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.|Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Spalek
authors.affiliation: Division of Cognitive Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.|Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.
authors.forename: D
authors.identifier: http://orcid.org/0000-0001-5028-5807
authors.initials: D
authors.lastname: Coynel
authors.affiliation: Division of Cognitive Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.|Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.
authors.forename: V
authors.initials: V
authors.lastname: Freytag
authors.affiliation: Division of Cognitive Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.|Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.
authors.forename: F
authors.identifier: http://orcid.org/0000-0001-7511-3251
authors.initials: F
authors.lastname: Hartmann
authors.affiliation: Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.|Psychiatric University Clinics, University of Basel, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Heck
authors.affiliation: Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.|Psychiatric University Clinics, University of Basel, Basel, Switzerland.
authors.forename: A
authors.identifier: http://orcid.org/0000-0002-3933-3289
authors.initials: A
authors.lastname: Milnik
authors.affiliation: Division of Cognitive Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.|Psychiatric University Clinics, University of Basel, Basel, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: de Quervain
authors.affiliation: Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.|Psychiatric University Clinics, University of Basel, Basel, Switzerland.|Department Biozentrum, Life Sciences Training Facility, University of Basel, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Papassotiropoulos
mesh_terms: D000293:Adolescent; D000328:Adult; D001143:Arousal / Q000235:genetics*; D056324:Diffusion Tensor Imaging; D004644:Emotions; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D020813:Receptor, trkB; D066127:White Matter / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D008562:Membrane Glycoproteins; D011505:Protein-Tyrosine Kinases; D020813:Receptor, trkB; C000591259:tropomyosin-related kinase-B, human