title: MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling.
abstract: BACKGROUND
  MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive.
  
  
  RESULTS
  Decreased expression of miRNA-203 was correlated with tumor size, poor prognosis and recurrence in GC patients. Overexpression of miR-203 or knockdown of its target progesterone immunomodulatory binding factor 1 (PIBF1) inhibited GC growth in vitro and in vivo, while miR-203 knockdown promoted GC proliferation. In addition, PIBF1 overexpression attenuated the inhibitory effects of miR-203 on GC growth and enhanced that effect on p-Akt expression.
  
  
  CONCLUSIONS
  MiR-203 as a tumor biomarker suppresses GC growth through targeting the PIBF1/Akt signaling, suggesting that it may have the important therapeutic potential for the treatment of GC.
authors.affiliation: Department of Gerontology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Shanghai, 200233, China.
authors.forename: Shao-Jun
authors.initials: SJ
authors.lastname: Chu
authors.affiliation: Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Yishan Road No. 600, Shanghai, 200233, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Yishan Road No. 600, Shanghai, 200233, China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Yishan Road No. 600, Shanghai, 200233, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Yishan Road No. 600, Shanghai, 200233, China.
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Huang
authors.affiliation: Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Yishan Road No. 600, Shanghai, 200233, China.
authors.forename: Yun-Min
authors.initials: YM
authors.lastname: Lu
authors.affiliation: Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Yishan Road No. 600, Shanghai, 200233, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Da
authors.affiliation: Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Yishan Road No. 600, Shanghai, 200233, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Yishan Road No. 600, Shanghai, 200233, China. jing5522724@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Yishan Road No. 600, Shanghai, 200233, China. zhujs1803@163.com.
authors.forename: Jin-Shui
authors.initials: JS
authors.lastname: Zhu
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D011257:Pregnancy Proteins / Q000235:genetics*; D011379:Prognosis; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics*; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology*; D013491:Suppressor Factors, Immunologic / Q000235:genetics*
chemical_list: C546703:MIRN203 microRNA, human; D035683:MicroRNAs; C110058:PIBF1 protein, human; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic; D051057:Proto-Oncogene Proteins c-akt
keywords: Akt; Gastric cancer; Growth; PIBF1; miRNA-203