title: Usefulness of Heart-Type Fatty Acid-Binding Protein and Myocardial Performance Index for Early Detection of 5-Fluorouracil Cardiotoxicity.
abstract: In the present study, we aimed to evaluate temporal changes in heart-type fatty acid-binding protein (h-FABP) and myocardial performance index (Tei index) following administration of 5-fluorouracil (5-FU), a chemotherapeutic agent associated with myocardial ischemia induced by coronary vasospasm. Thirty-two patients with cancer receiving their first 5-FU-based chemotherapy were included in the study. Prior to chemotherapy and 24 hours after the initiation of chemotherapy, all patients underwent a comprehensive echocardiographic examination. Blood samples were taken for h-FABP and troponin I (TnI) measurements at different time points during the first 24 hours of 5-FU administration. Postinfusion echocardiography revealed worsening in Tei index (0.37 ± 0.08 vs 0.43 ± 0.07, P < .001). Clinically overt cardiotoxicity was evident in 4 (12.5%) of our patient population. Heart-type fatty acid binding protein and TnI levels were within normal ranges at all time points. Our results suggest that ischemia coronary vasospasm due to 5-FU cardiotoxicity should be reviewed. Furthermore, Tei index might be a sensitive indicator of occult 5-FU cardiotoxicity.
authors.affiliation: Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey drtt61@gmail.com.
authors.forename: Turhan
authors.initials: T
authors.lastname: Turan
authors.affiliation: Department of Cardiology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
authors.forename: Mustafa Tarik
authors.initials: MT
authors.lastname: Agac
authors.affiliation: Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Ahmet Çağrı
authors.initials: AÇ
authors.lastname: Aykan
authors.affiliation: Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Kul
authors.affiliation: Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Ali Rıza
authors.initials: AR
authors.lastname: Akyüz
authors.affiliation: Department of Cardiology, Kafkas University Hospital, Kars, Turkey.
authors.forename: Tayyar
authors.initials: T
authors.lastname: Gökdeniz
authors.affiliation: Department of Cardiology, Izmir Sifa University Hospital, Izmir, Turkey.
authors.forename: İlker
authors.initials: İ
authors.lastname: Gül
authors.affiliation: Department of Clinical Oncology, Kanuni Education and Research Hospital, Trabzon, Turkey.
authors.forename: Ercüment
authors.initials: E
authors.lastname: Cengiz
authors.affiliation: Department of Cardiology, Samsun Education and Research Hospital, Samsun, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Boyacı
authors.affiliation: Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Erkan
authors.affiliation: Department of Cardiology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Akdemir
authors.affiliation: Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
authors.forename: Sukru
authors.initials: S
authors.lastname: Celik
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D066126:Cardiotoxicity / Q000097:blood / Q000175:diagnosis*; D042241:Early Diagnosis; D004452:Echocardiography / Q000379:methods; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins; D005472:Fluorouracil
keywords: 5-fluorouracil; cardiotoxicity; echocardiography; heart-type fatty acid-binding protein