title: Effect of Dexamethasone and Pheniramine Maleate in Patients Undergoing Elective Laparoscopic Cholecystectomy.
abstract: BACKGROUND
  Laparoscopic cholecystectomy (LC) is elective surgical procedure for uncomplicated gallstone disease and gallbladder polyp. The objective of this study was to assess the efficacy of Dexamethasone and Pheniramine hydrogen maleate on reducing stress response and pain after surgery in patients undergoing laparoscopic cholecystectomy.
  
  
  METHODS
  After obtaining approval from the institutional ethics committee and written informed consent, 120 patients undergoing elective laparoscopic cholecystectomy were enrolled in the study from Sep 2103 to Aug 2014 at Department of Surgery, Manipal College of Medical Sciences, Pokhara, Nepal. Patients were randomized to receive either 8mg/2ml of Dexamethasone + 45.5/2ml Pheniramine hydrogen maleate (treatment group, n= 60) or 5 ml of normal saline (control group, n=60) 90 minutes before skin incision.
  
  
  RESULTS
  There was a reduction of total bilirubin, C-reactive protein (CRP) value and Visual Analogue Score (VAS) in treatment group as compared to control group (p <0.05).
  
  
  CONCLUSIONS
  Use of Dexamethasone and Pheniramine hydrogen maleate prior to surgical skin incision helps to reduce both postoperative pain and acute physiological stress.
authors.affiliation: Department of Surgery, Manipal College of Medical Sciences, Kaski, pokhara, Nepal.
authors.forename: B B
authors.initials: BB
authors.lastname: Shrestha
authors.affiliation: Department of Surgery, Manipal College of Medical Sciences, Kaski, pokhara, Nepal.
authors.forename: M
authors.initials: M
authors.lastname: Karmacharya
authors.affiliation: Department of Surgery, Manipal College of Medical Sciences, Kaski, pokhara, Nepal.
authors.forename: B B
authors.initials: BB
authors.lastname: Gharti
authors.affiliation: Department of Surgery, Manipal College of Medical Sciences, Kaski, pokhara, Nepal.
authors.forename: B
authors.initials: B
authors.lastname: Timilsina
authors.affiliation: Department of Surgery, Manipal College of Medical Sciences, Kaski, pokhara, Nepal.
authors.forename: P
authors.initials: P
authors.lastname: Ghimire
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002097:C-Reactive Protein / Q000032:analysis; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects / Q000379:methods; D041761:Cholecystolithiasis / Q000175:diagnosis / Q000601:surgery*; D003907:Dexamethasone / Q000008:administration & dosage*; D016903:Drug Monitoring; D005260:Female; D005704:Gallbladder / Q000473:pathology / Q000601:surgery; D006634:Histamine H1 Antagonists / Q000008:administration & dosage; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D010632:Pheniramine / Q000008:administration & dosage*; D011127:Polyps / Q000175:diagnosis / Q000601:surgery*; D013312:Stress, Physiological / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D006634:Histamine H1 Antagonists; D010632:Pheniramine; D003907:Dexamethasone; D002097:C-Reactive Protein
keywords: C - reactive protein; dexamethasone; laparoscopic cholecystectomy; pheniramine hydrogen maleate.