title: Efficacy of rasagiline in early Parkinson's disease: a meta-analysis of data from the TEMPO and ADAGIO studies.
abstract: OBJECTIVE
  To evaluate the efficacy of rasagiline versus placebo in a pooled population of patients with early Parkinson's disease (PD).
  
  
  METHODS
  TEMPO and ADAGIO were Phase III studies that evaluated the symptomatic efficacy of rasagiline versus placebo in patients with early PD. This meta-analysis included Unified Parkinson's Disease Rating Scale (UPDRS) observations from weeks 12, 24 and 36 in ADAGIO and from weeks 14 and 26 in TEMPO; TEMPO visits were recoded to weeks 12 and 24, respectively. The present analysis includes all patients who received rasagiline 1 mg/day, 2 mg/day or placebo, and had ≥1 post-baseline observations and a subgroup of patients whose baseline UPDRS Total scores were ≥27 (Upper Quartile population). Change from baseline in UPDRS scores were evaluated using mixed models repeated measures analyses.
  
  
  RESULTS
  Of the 1578 patients randomized to the two studies, 1546 patients met criteria for inclusion in the meta-analysis. Effects on UPDRS Total, motor and activities of daily living scores were significantly better for both doses of rasagiline compared with placebo at all time periods. The Upper Quartile population included 402 patients with a UPDRS Total score ≥27 at baseline. These patients generally demonstrated a larger magnitude of treatment effect than was seen in the full population.
  
  
  CONCLUSIONS
  This meta-analysis confirms the efficacy of rasagiline monotherapy over 36 weeks. Although TEMPO and ADAGIO are considered studies of "very early" PD, both contained a sizeable pool of patients with more severe disease. In addition, the meta-analysis showed a larger magnitude of effect in patients with more severe baseline disease.
authors.affiliation: a Parkinson's Disease and Movement Disorders Center , University of South Florida, National Parkinson Foundation Center of Excellence , Tampa , FL , USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Hauser
authors.affiliation: b Teva Pharmaceuticals , Frazer , PA , USA , and.
authors.forename: Victor
authors.initials: V
authors.lastname: Abler
authors.affiliation: c Teva Pharmaceuticals , Petah Tikva , Israel.
authors.forename: Eli
authors.initials: E
authors.lastname: Eyal
authors.affiliation: c Teva Pharmaceuticals , Petah Tikva , Israel.
authors.forename: Rom E
authors.initials: RE
authors.lastname: Eliaz
mesh_terms: D017326:Clinical Trials, Phase III as Topic / Q000706:statistics & numerical data*; D006801:Humans; D007189:Indans / Q000008:administration & dosage / Q000494:pharmacology*; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D010300:Parkinson Disease / Q000188:drug therapy*
chemical_list: D007189:Indans; D008996:Monoamine Oxidase Inhibitors; C031967:rasagiline
keywords: Parkinson's disease; efficacy; rasagiline; treatment