title: The role of IL-1β in Pseudomonas aeruginosa in lung infection.
abstract: This mini-review examines the role of the pro-inflammatory cytokine interleukin (IL)-1β in the interaction of Pseudomonas aeruginosa and the host immune system during lung infection. Different studies show that the reduction of the inflammatory response, especially a decrease in IL-1β, leads to a better outcome in acute lung infection with this bacterium. This includes a higher survival rate, reduced damage to the lung tissue and, in particular, a better clearance of the airways and the tissue of the lungs from P. aeruginosa.
authors.affiliation: Department of Anatomy and Cell Biology, Saarland University, Kirrberger Strasse, 66424, Homburg, Saar, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Wonnenberg
authors.affiliation: Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Bischoff
authors.affiliation: Department of Internal Medicine V, Pneumology, Allergology and Respiratory Critical Care Medicine, Saarland University, Homburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Beisswenger
authors.affiliation: Department of Experimental Pneumology and Allergology, Saarland University, Homburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Dinh
authors.affiliation: Department of Internal Medicine V, Pneumology, Allergology and Respiratory Critical Care Medicine, Saarland University, Homburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Bals
authors.affiliation: Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.affiliation: Department of Anatomy and Cell Biology, Saarland University, Kirrberger Strasse, 66424, Homburg, Saar, Germany. thomas.tschernig@uks.eu.
authors.forename: T
authors.initials: T
authors.lastname: Tschernig
mesh_terms: D000818:Animals; D006801:Humans; D058847:Inflammasomes / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D053583:Interleukin-1beta / Q000276:immunology*; D008168:Lung / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D011552:Pseudomonas Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D011550:Pseudomonas aeruginosa / Q000276:immunology*
chemical_list: C508585:IL1B protein, human; D058847:Inflammasomes; D053583:Interleukin-1beta
keywords: IL-1β; Inflammasomes; Inflammation; Pneumonia; Pseudomonas aeruginosa