title: Polygenic risk for type 2 diabetes mellitus among individuals with psychosis and their relatives.
abstract: BACKGROUND
  An elevated prevalence of Type 2 diabetes (T2D) has been observed in people with psychotic disorders and their relatives compared to the general population. It is not known whether this population also has increased genetic risk for T2D.
  
  
  METHODS
  Subjects included probands with schizophrenia, schizoaffective disorder, or psychotic bipolar I disorder, their first-degree relatives without psychotic disorders, and healthy controls, who participated in the Bipolar Schizophrenia Network for Intermediate Phenotypes study. We constructed sets of polygenic risk scores for T2D (PGRST2D) and schizophrenia (PGRSSCHIZ) using publicly available data from genome-wide association studies. We then explored the correlation of PGRST2D with psychiatric proband or relative status, and with self-reported diabetes. Caucasians and African-Americans were analyzed separately. We also evaluated correlations between PGRSSCHIZ and diabetes mellitus among Caucasian probands and their relatives.
  
  
  RESULTS
  In Caucasians, PGRST2D was correlated with self-reported diabetes mellitus within probands, but was not correlated with proband or relative status in the whole sample. In African-Americans, a PGRST2D based on selected risk alleles for T2D in this population did not correlate with proband or relative status. PGRSSCHIZ was not correlated with self-reported diabetes within Caucasian probands.
  
  
  CONCLUSIONS
  Differences in polygenic risk for T2D do not explain the increased prevalence of diabetes mellitus observed in psychosis probands and their relatives.
authors.affiliation: Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Behavioral Neurology and Neuropsychiatry, McLean Hospital, Belmont, MA, USA.
authors.forename: Jaya L
authors.initials: JL
authors.lastname: Padmanabhan
authors.affiliation: College of Physicians & Surgeons, Columbia University Medical Center, New York, NY, USA.
authors.forename: Pranav
authors.initials: P
authors.lastname: Nanda
authors.affiliation: Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Baylor College of Medicine, Texas Medical Center, Houston, TX, USA.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Tandon
authors.affiliation: Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Suraj S
authors.initials: SS
authors.lastname: Mothi
authors.affiliation: Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bolo
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: McCarroll
authors.affiliation: Department of Psychology, BioImaging Research Center, University of Georgia, Athens, GA, USA; Department of Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA, USA.
authors.forename: Brett A
authors.initials: BA
authors.lastname: Clementz
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Chicago, IL, USA; Department of Human Genetics, University of Chicago, IL, USA.
authors.forename: Elliot S
authors.initials: ES
authors.lastname: Gershon
authors.affiliation: Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA; Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Godfrey D
authors.initials: GD
authors.lastname: Pearlson
authors.affiliation: Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Sweeney
authors.affiliation: Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Tamminga
authors.affiliation: Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address: mkeshava@bidmc.harvard.edu.
authors.forename: Matcheri S
authors.initials: MS
authors.lastname: Keshavan
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020412:Multifactorial Inheritance; D015995:Prevalence; D011618:Psychotic Disorders / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D012306:Risk; D012559:Schizophrenia / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D057566:Self Report; D044465:White People / Q000235:genetics
chemical_list: D014150:Antipsychotic Agents
keywords: Bipolar; Diabetes; Genetic; Polygenic; Psychosis; Schizophrenia