title: [Sentinel node detection using optonuclear probe (gamma and fluorescence) after green indocyanine and radio-isotope injections].
abstract: OBJECTIVE
  Assess the biopsy's feasibility of the sentinel lymph node biopsy (SLNB) using optonuclear probe after of indocyanine green (ICG) and radio-isotope (RI) injections.
  
  
  METHODS
  Twenty-one patients with a localized breast cancer and unsuspicious axillary nodes underwent a SLNB after both injections of ICG and radio-isotope.
  
  
  RESULTS
  One or more SLN were identified on the 21 patients (identification rate of 100%). The median number SLN was 2 (1-3). Twenty SLN were both radio-actives and fluorescents (54.1%), 11 fluorescent only (29.7%) and 6 were only radio-actives (16.2%). Seven patients had a metastatic SLN (8 SLN overall). Among them, only one had a micrometastasic SLN, 5 others had a macrometastatic SLN and one patient had two macrometastatic SLNs. Among the 8 metastatic SLN, 5 were both fluorescent and radioactive, 2 were only fluorescent and 1 was only radioactive.
  
  
  CONCLUSIONS
  Detection SLN using optonuclear probe after indocyanine green and radio-isotope injections is effective and could be, after validation by randomized trial, a reliable alternative to the blue dye injection for teams who consider that combined detection as the reference.
authors.affiliation: Pole de chirurgie oncologique générale, gynécologique et mammaire, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
authors.forename: M-A
authors.initials: MA
authors.lastname: Poumellec
authors.affiliation: Pole de chirurgie oncologique générale, gynécologique et mammaire, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
authors.forename: M
authors.initials: M
authors.lastname: Dejode
authors.affiliation: Pole de chirurgie oncologique générale, gynécologique et mammaire, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
authors.forename: A
authors.initials: A
authors.lastname: Figl
authors.affiliation: Département de médecine nucléaire, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
authors.forename: J
authors.initials: J
authors.lastname: Darcourt
authors.affiliation: Département d'anatomie-pathologique, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
authors.forename: J
authors.initials: J
authors.lastname: Haudebourg
authors.affiliation: Pole de chirurgie oncologique générale, gynécologique et mammaire, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Sabah
authors.affiliation: Pole de chirurgie oncologique générale, gynécologique et mammaire, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
authors.forename: A
authors.initials: A
authors.lastname: Voury
authors.affiliation: Pole de chirurgie oncologique générale, gynécologique et mammaire, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
authors.forename: A
authors.initials: A
authors.lastname: Martaens
authors.affiliation: Pole de chirurgie oncologique générale, gynécologique et mammaire, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France. Electronic address: emmanuel.barranger@nice.unicancer.fr.
authors.forename: E
authors.initials: E
authors.lastname: Barranger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D007208:Indocyanine Green; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D011868:Radioisotopes; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes; D011868:Radioisotopes; D007208:Indocyanine Green
keywords: Biopsie du ganglion sentinelle; Breast cancer; Cancer du sein; Combined detection; Détection combinée; Indocyanine green; Radio-isotope; Sentinel node biopsy; Vert indocyanine