title: Protective Effects of 7-Hydroxycoumarin on Dyslipidemia and Cardiac Hypertrophy in Isoproterenol-Induced Myocardial Infarction in Rats.
abstract: This study evaluates the protective effects of 7-hydroxycoumarin (7-HC) on dyslipidemia and cardiac hypertrophy in isoproterenol (ISO) induced myocardial infarction (MI) in rats. Rats were pre- and co treated with 7-HC (16 mg/kg) daily for 8 days. ISO (100 mg/kg) was subcutaneously injected into rats on seventh and eighth days to induce MI. Increased activity/levels of serum creatine kinase-MB (CK-MB), troponin-T, plasma lipid peroxidation products, and altered levels of lipids in the serum and heart and serum lipoproteins were noted in ISO-induced rats. ISO-induced myocardial infarcted rats revealed increased hypertrophy (cardiac and left ventricular) and hepatic 3-hydroxyl 3-methylglutaryl-coenzyme-A reductase (HMG-CoA reductase) activity. Pre and cotreatment with 7-HC revealed significant protective effects on all the biochemical parameters evaluated. The in vitro study demonstrated its free radical scavenging property. Thus, 7-HC protects ISO-induced MI in rats by its free radical scavenging and antihyperlipidaemic and antihypertrophic properties.
authors.affiliation: Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar- 608 002, India.
authors.forename: Govindan Sangaran
authors.initials: GS
authors.lastname: Jagadeesh
authors.affiliation: Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar- 608 002, India.
authors.forename: M F
authors.initials: MF
authors.lastname: Nagoor Meeran
authors.affiliation: Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar- 608 002, India.
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Selvaraj
mesh_terms: D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D000818:Animals; D006332:Cardiomegaly / Q000517:prevention & control*; D050171:Dyslipidemias / Q000188:drug therapy*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D007545:Isoproterenol / Q000008:administration & dosage*; D008099:Liver / Q000201:enzymology; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D014468:Umbelliferones / Q000627:therapeutic use*
chemical_list: D000318:Adrenergic beta-Agonists; D014468:Umbelliferones; C031477:7-hydroxycoumarin; D006903:Hydroxymethylglutaryl CoA Reductases; D007545:Isoproterenol
keywords: 7-Hydroxycoumarin; Cardiac hypertrophy; Dyslipidemia; Isoproterenol; Myocardial infarction