title: Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity.
abstract: We compared the acute toxicity of nanosilica and polyacrylate/nanosilica instillation in Wistar rats (n = 60). Exposure to nanosilica and polyacrylate/nanosilica showed a 30% mortality rate. When compared with saline-treated rats, animals in both exposure groups exhibited a significant reduction of PO2 (P < 0.05) at both 24 and 72 hr. after exposure. Both exposure groups exhibited a significant reduction of neutrophils in arterial blood compared to saline controls (P < 0.05) 24 hr. after exposure. The levels of blood ALT and LDH in exposed groups were found to be significantly increased (P < 0.05) 24 hr. following exposure. The exposed groups exhibited various degrees of pleural effusion and pericardial effusion. Our findings indicated respiratory exposure to polyacrylate/nanosilica and nanosilica is likely to cause multiple organ toxicity.
authors.affiliation: Occupational Disease and Toxicology Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Ying-Mei
authors.initials: YM
authors.lastname: Niu
authors.affiliation: Occupational Disease and Toxicology Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zhu
authors.affiliation: Department of Toxicology, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Chang
authors.affiliation: Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Tong
authors.affiliation: Department of Ultrasonography, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Cao
authors.affiliation: Department of Toxicology, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Pei-Huan
authors.initials: PH
authors.lastname: Qiao
authors.affiliation: Department of Toxicology, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Lin-Yuan
authors.initials: LY
authors.lastname: Zhang
authors.affiliation: Occupational Disease and Toxicology Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Occupational Disease and Toxicology Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Yu-Guo
authors.initials: YG
authors.lastname: Song
mesh_terms: D000180:Acrylic Resins / Q000633:toxicity*; D000818:Animals; D008297:Male; D053758:Nanoparticles / Q000633:toxicity*; D009504:Neutrophils / Q000378:metabolism / Q000473:pathology; D010490:Pericardial Effusion / Q000097:blood / Q000139:chemically induced; D010996:Pleural Effusion / Q000097:blood / Q000139:chemically induced; D051381:Rats; D017208:Rats, Wistar; D012822:Silicon Dioxide / Q000633:toxicity*
chemical_list: D000180:Acrylic Resins; C006903:carbopol 940; D012822:Silicon Dioxide