title: Controllable Multicompartmental Capsules with Distinct Cores and Shells for Synergistic Release.
abstract: A facile and flexible approach is developed for controllable fabrication of novel multiple-compartmental calcium alginate capsules from all-aqueous droplet templates with combined coextrusion minifluidic devices for isolated coencapsulation and synergistic release of diverse incompatible components. The multicompartmental capsules exhibit distinct compartments, each of which is covered by a distinct part of a heterogeneous shell. The volume and number of multiple compartments can be well-controlled by adjusting flow rates and device numbers for isolated and optimized encapsulation of different components, while the composition of different part of the heterogeneous shell can be individually tailored by changing the composition of droplet template for flexibly tuning the release behavior of each component. Two combined devices are first used to fabricate dual-compartmental capsules and then scaled up to fabricate more complex triple-compartmental capsules for coencapsulation. The synergistic release properties are demonstrated by using dual-compartmental capsules, which contain one-half shell with a constant release rate and the other half shell with a temperature-dependent release rate. Such a heterogeneous shell provides more flexibilities for synergistic release with controllable release sequence and release rates to achieve advanced and optimized synergistic efficacy. The multicompartmental capsules show high potential for applications such as drug codelivery, confined reactions, enzyme immobilizations, and cell cultures.
authors.affiliation: School of Chemical Engineering, Sichuan University , No. 24, Southern 1 Section, Yihuan Road, Chengdu, Sichuan 610065, People's Republic of China.
authors.forename: Fan
authors.initials: F
authors.lastname: He
authors.affiliation: School of Chemical Engineering, Sichuan University , No. 24, Southern 1 Section, Yihuan Road, Chengdu, Sichuan 610065, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: School of Chemical Engineering, Sichuan University , No. 24, Southern 1 Section, Yihuan Road, Chengdu, Sichuan 610065, People's Republic of China.
authors.forename: Xiao-Heng
authors.initials: XH
authors.lastname: He
authors.affiliation: School of Chemical Engineering, Sichuan University , No. 24, Southern 1 Section, Yihuan Road, Chengdu, Sichuan 610065, People's Republic of China.
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Yang
authors.affiliation: School of Chemical Engineering, Sichuan University , No. 24, Southern 1 Section, Yihuan Road, Chengdu, Sichuan 610065, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: School of Chemical Engineering, Sichuan University , No. 24, Southern 1 Section, Yihuan Road, Chengdu, Sichuan 610065, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xie
authors.affiliation: School of Chemical Engineering, Sichuan University , No. 24, Southern 1 Section, Yihuan Road, Chengdu, Sichuan 610065, People's Republic of China.
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Ju
authors.affiliation: School of Chemical Engineering, Sichuan University , No. 24, Southern 1 Section, Yihuan Road, Chengdu, Sichuan 610065, People's Republic of China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Chemical Engineering, Sichuan University , No. 24, Southern 1 Section, Yihuan Road, Chengdu, Sichuan 610065, People's Republic of China.|State Key Laboratory of Polymer Materials Engineering, Sichuan University , Chengdu, Sichuan 610065, People's Republic of China.|Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) , Nanjing, Jiangsu 211816, People's Republic of China.
authors.forename: Liang-Yin
authors.initials: LY
authors.lastname: Chu
mesh_terms: D000464:Alginates / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D002214:Capsules / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D004357:Drug Synergism; D020723:Glucuronic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D006603:Hexuronic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D056656:Lab-On-A-Chip Devices
chemical_list: D000464:Alginates; D002214:Capsules; D006603:Hexuronic Acids; D020723:Glucuronic Acid
keywords: calcium alginate; coencapsulation; distinct shells; multicompartmental capsules; synergistic release