title: MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia.
abstract: Chronic myeloid leukemia (CML) is a severe problem throughout the world and requires identification of novel targets for its treatment. This multifactorial disease accounts for about 15% of the all diagnosed leukemia cases. Mitogen-activated protein kinase (MAPK) signaling pathway is crucial for the cell survival and its dysregulation is being implicated in various types of cancers. In here, we have discussed the potential role of various miRNAs that are found involved in regulating the proteins cascades of MAPK signaling pathway associated with CML. An emphasis has been paid to summarize the influence of various miRNAs in elevating or suppressing the expression level of significant proteins such as miR-203, miR-196a, miR-196b, miR-30a, miR-29b, miR-138 in BCR-ABL tyrosine kinase; miR-126, miR-221, miR-128, miR-15a, miR-188-5p, miR-17 in CRK family proteins; miR-155, miR-181a with SOS proteins; miR-155, miR-19a, with KRAS proteins; miR-19a with RAF1 protein; and miR-17, miR-19a, miR-17-92 cluster with MAPK/ERK proteins. In light of ever-increasing importance and ever-widening regulatory roles of miRNAs in cells, we have reviewed the recent progress in the field of miRNAs and have tried to suggest them as controlling targets for various protein cascades of MAPK signaling pathway. An understanding of the supervisory mechanism of MAPK by miRNAs might provide novel targets for treating CML.
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, Korea.|Department of Bio-informatics, School of Computer and Information Sciences, Galgotias University, Greater Noida, Uttar Pradesh, 203201, India.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, Korea.
authors.forename: Ashish Ranjan
authors.initials: AR
authors.lastname: Sharma
authors.affiliation: Aquaculture Research Unit, Department of Zoology, Vidyasagar University, Midnapore, West Bengal, 721102, India.
authors.forename: Bidhan Chandra
authors.initials: BC
authors.lastname: Patra
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, Korea.|Aquaculture Research Unit, Department of Zoology, Vidyasagar University, Midnapore, West Bengal, 721102, India.
authors.forename: Manojit
authors.initials: M
authors.lastname: Bhattacharya
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, Korea.
authors.forename: Garima
authors.initials: G
authors.lastname: Sharma
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, Korea.
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000818:Animals; D002470:Cell Survival; D002874:Chromosome Mapping; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D000068877:Imatinib Mesylate; D020014:K562 Cells; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D000068877:Imatinib Mesylate; D016044:Fusion Proteins, bcr-abl; D020928:Mitogen-Activated Protein Kinases
keywords: MAPK; chronic myeloid leukemia; microRNA; oncogenic; signaling pathway