title: Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication.
abstract: Most physiological functions originate with the communication between organs. Mouse genetics has revived this holistic view of physiology through the identification of inter-organ communications that are unanticipated, functionally important, and would have been difficult to uncover otherwise. This Review highlights this point by showing how two tissues usually not seen as endocrine ones, bone and striated muscles, influence several physiological processes in a significant manner.
authors.affiliation: Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: gk2172@cumc.columbia.edu.
authors.forename: Gerard
authors.initials: G
authors.lastname: Karsenty
authors.affiliation: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Eric N
authors.initials: EN
authors.lastname: Olson
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D016207:Cytokines / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D051379:Mice; D018482:Muscle, Skeletal / Q000502:physiology*; D015675:Osteocalcin; D010710:Phosphates / Q000378:metabolism
chemical_list: D016207:Cytokines; D010710:Phosphates; D015675:Osteocalcin