title: Applying lessons learned from cytomegalovirus infection in transplant patients to vaccine design.
abstract: Studies in transplant recipients over the past decade aiming to characterize the immune response to cytomegalovirus (CMV) replication have provided insights that can be used to guide CMV vaccine development. These studies have characterized multiple aspects of the immune response to virus infection in humans, and have identified immunologic variables that correlate with the ability to control virus replication. These findings can be used to guide vaccine development by informing decisions regarding antigen selection and the type of immune response that must be elicited by these antigens to promote protective immunity. In addition, these studies have provided information that could aid in the identification of immunologic endpoints in vaccine clinical trials, thus facilitating their design and implementation.
authors.affiliation: Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Blanco-Lobo
authors.affiliation: Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Bulnes-Ramos
authors.affiliation: Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: McConnell
authors.affiliation: Microbiology Service, Hospital Clínico Universitario, Fundación INCLIVA, Valencia, Spain; Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Navarro
authors.affiliation: Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain. Electronic address: mperez-ibis@us.es.
authors.forename: Pilar
authors.initials: P
authors.lastname: Pérez-Romero
mesh_terms: D000956:Antigens, Viral / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D006801:Humans; D016377:Organ Transplantation; D014181:Transplantation Immunology; D014765:Viral Vaccines
chemical_list: D000956:Antigens, Viral; D014765:Viral Vaccines