title: KLF4 Initiates Acinar Cell Reprogramming and Is Essential for the Early Stages of Pancreatic Carcinogenesis.
abstract: Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and is minimally responsive to current chemotherapies. In this issue of Cancer Cell, Xie et al. (2016) identify the transcription factor KLF4 as essential for the early stages of pancreatic carcinogenesis, expanding the repertoire of targets for early intervention strategies.
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-4863, USA.
authors.forename: Ravikanth
authors.initials: R
authors.lastname: Maddipati
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-4863, USA. Electronic address: jpkatz@mail.med.upenn.edu.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Katz
mesh_terms: D061354:Acinar Cells / Q000473:pathology*; D000818:Animals; D063646:Carcinogenesis / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D010179:Pancreas / Q000473:pathology*; D010183:Pancreatic Ducts / Q000473:pathology*; D011230:Precancerous Conditions / Q000235:genetics*
chemical_list: C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors