title: Peptide-based synthetic pulmonary surfactant for the treatment of respiratory distress disorders.
abstract: KL4 (sinapultide) represents the first peptide-based replacement for surfactant protein B in pulmonary surfactant (PS) therapies approved for clinical use. Surfaxin, its formulation with PS lipids, shows the promise of synthetic PS for replacing animal-derived PS in the treatment of respiratory distress syndromes and for treating acute lung injury. Efforts to characterize the molecular basis for KL4 function have revealed the peptide exhibits a helical structure which differentially partitions in response to both lipid saturation levels and pH. The penta-residue repeat of KL4 leads to adaptive peptide helicity, varying with partitioning depth, and suggests structural plasticity may represent an important mechanism for differential trafficking of lipids, particularly in intra-alveolar surfactant for the formation of stable DPPC monolayers at air-water interfaces.
authors.affiliation: Department of Chemistry, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Otonye
authors.initials: O
authors.lastname: Braide-Moncoeur
authors.affiliation: Department of Chemistry, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Nhi T
authors.initials: NT
authors.lastname: Tran
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address: jrlong@ufl.edu.
authors.forename: Joanna R
authors.initials: JR
authors.lastname: Long
mesh_terms: D000818:Animals; D006801:Humans; D008051:Lipid Bilayers; D010455:Peptides / Q000627:therapeutic use*; D011663:Pulmonary Surfactants / Q000737:chemistry / Q000627:therapeutic use*; D012140:Respiratory Tract Diseases / Q000188:drug therapy*
chemical_list: D008051:Lipid Bilayers; D010455:Peptides; D011663:Pulmonary Surfactants