title: Hyaluronic Acid Improves Bone Formation in Extraction Sockets With Chronic Pathology: A Pilot Study in Dogs.
abstract: Previous studies on ridge preservation focusing on fresh extraction sockets using graft materials for ridge preservation procedures have reported a delay in the tissue modeling and remodeling phases. The objective of this study is to evaluate the effect of hyaluronic acid (HA) on healing of infected sockets.
  
  
  
  Six beagle dogs were used in this study. Both mandibular third premolars were hemisected, and the distal roots were extracted. Subsequently, periodontal and endodontic lesions were induced at the remaining mesial root. After communication of the periodontal lesion, an endodontic periapical lesion was observed at 4 months, and the mesial roots of both the right and left sides were extracted. HA was applied into the socket of the test group, and no treatment was administered to the other group (control group). Three months after extraction of the mesial roots, the dogs were sacrificed, and histologic evaluations were performed.
  
  
  
  The sockets were filled by mineralized bone (47.80% ± 6.60%) and bone marrow (50.47% ± 6.38%) in the control group, whereas corresponding values were 63.29% ± 9.78% and 34.73% ± 8.97% for the test group, respectively. There was a statistically significant difference between the groups. Reversal lines and a copious lineup of osteoblasts were observed in the middle and apical parts of the sockets in the test group.
  
  
  
  An infected socket shows delayed healing of the socket wound, and HA, because of its osteoinductive, bacteriostatic, and anti-inflammatory properties, may improve bone formation and accelerate wound healing in infected sockets.
authors.affiliation: Department of Periodontology and Dental Research Institute, Translational Research Laboratory for Tissue Engineering, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
authors.forename: Jung-Ju
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Department of Periodontology and Dental Research Institute, Translational Research Laboratory for Tissue Engineering, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Song
authors.affiliation: Department of Periodontology and Dental Research Institute, Translational Research Laboratory for Tissue Engineering, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
authors.forename: Heithem
authors.initials: H
authors.lastname: Ben Amara
authors.affiliation: Department of Oral Pathology, School of Dentistry, Seoul National University.
authors.forename: Kang
authors.initials: K
authors.lastname: Kyung-Rim
authors.affiliation: Department of Periodontology and Dental Research Institute, Translational Research Laboratory for Tissue Engineering, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
authors.forename: Ki-Tae
authors.initials: KT
authors.lastname: Koo
mesh_terms: D000818:Animals; D004285:Dogs; D006820:Hyaluronic Acid / Q000494:pharmacology*; D010012:Osteogenesis / Q000187:drug effects*; D010865:Pilot Projects; D014081:Tooth Extraction; D020390:Tooth Socket
chemical_list: D006820:Hyaluronic Acid
keywords: Chronic disease; hyaluronic acid; osteogenesis; pilot projects; tooth socket; wound healing