title: Prenylfuranocoumarin-HMGA-flavonol glucoside conjugates and other constituents of the fruit peels of Citrus hystrix and their anticholinesterase activity.
abstract: Sixteen compounds including dihydroxy prenylfuranocoumarins/3-hydroxy-3-methylglutaric acid conjugates and dihydroxy prenylfuranocoumarins/3-hydroxy-3-methylglutaric acid/1-O-flavonyl-β-d-glucopyranoside conjugates, together with other dihydroxyprenylfuranocoumarins conjugates, were isolated from the ethyl acetate extract of the fruit peels of Citrus hystrix. Some of the isolates were evaluated for their cholinesterase inhibitory activity, but only one compound possessing a 3-O-β-d-glucopyranosyl-3,5,7,4'-tetrahydroxy-6,8,3'-trimethoxyflavonol nucleus in the prenylfuranocoumarin-HMGA conjugate showed strong activity.
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Hua Mark, Bangkapi, Bangkok 10240, Thailand.
authors.forename: Chonticha
authors.initials: C
authors.lastname: Seeka
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Jatujak, Bangkok 10900, Thailand.
authors.forename: Pakawadee
authors.initials: P
authors.lastname: Sutthivaiyakit
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Hua Mark, Bangkapi, Bangkok 10240, Thailand.
authors.forename: Juthamanee
authors.initials: J
authors.lastname: Youkwan
authors.affiliation: Research Unit Analytical BioGeoChemistry, Department of Environmental Sciences, Helmholtz-Zentrum Munich, Neuherberg, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Hertkorn
authors.affiliation: Research Unit Analytical BioGeoChemistry, Department of Environmental Sciences, Helmholtz-Zentrum Munich, Neuherberg, Germany.
authors.forename: Mourad
authors.initials: M
authors.lastname: Harir
authors.affiliation: Research Unit Analytical BioGeoChemistry, Department of Environmental Sciences, Helmholtz-Zentrum Munich, Neuherberg, Germany; Technical University of Munich, Freising-Weihenstephan, Germany.
authors.forename: Philippe
authors.initials: P
authors.lastname: Schmitt-Kopplin
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Hua Mark, Bangkapi, Bangkok 10240, Thailand. Electronic address: s_somyote@ru.ac.th.
authors.forename: Somyote
authors.initials: S
authors.lastname: Sutthivaiyakit
mesh_terms: D000085:Acetates / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002957:Citrus / Q000737:chemistry*; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015093:Meglutol / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013785:Thailand
chemical_list: D000085:Acetates; D002800:Cholinesterase Inhibitors; D044948:Flavonols; D011564:Furocoumarins; D005960:Glucosides; C007650:ethyl acetate; D015093:Meglutol
keywords: Anticholinesterase activity; Citrus hystrix; Flavonol glucosides; Hydroxymethyl glutaric acid (HMGA) ester; Prenylfuranocoumarins; Rutaceae