title: [STRESS-INDUCED PATTERNS OF THE HYPOTHALAMIC CRH AND VASOPRESSIN EXPRESSION IN FEMALE RATS IN A MODEL OF POSTTRAUMATIC STRESS DISORDER].
abstract: The neuroendocrine mechanisms underlying anxiety-like state development in cycling female rats with different plasma estradiol levels have been studied in a stress-restress paradigm, an animal model of posttraumatic stress disorder (PTSD). The effect of stress-restress on the hypothalamic expression of corticotropin-releasing hormone (CRH) and vasopressin was analyzed by quantitative immunocytochemistry. Stress-restress was found to increase CRH expression in the hypothalamic paraventricular nucleus (PVN) on the 10th post-restress day, but the level of CRH expression in the PVN restored to the basal values on the 30th post-restress day in all experimental groups. It was shown an increase in vasopressin immunoreactivity in the PVN from the 10th to the 30th post-restress days in female rats exposed to stress during the estrus phase (low plasma estradiol level). In summary, female rats with low plasma estradiol level exhibited the most significant changes in the hypothalamic neuroendocrine system following stress-restress exposure. It might be hypothesized that hyperactivity of the hypothalamic circuit of the central vasopressinergic system is one of the possible mechanisms underlying PTSD-like state development in female rats in a stress-restress paradigm.
authors.forename: V I
authors.initials: VI
authors.lastname: Mironova
authors.forename: V V
authors.initials: VV
authors.lastname: Rakitskaya
authors.forename: S G
authors.initials: SG
authors.lastname: Pivina
authors.forename: N E
authors.initials: NE
authors.lastname: Ordyan
mesh_terms: D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000096:biosynthesis*; D004195:Disease Models, Animal; D030762:Estrous Cycle; D005260:Female; D005786:Gene Expression Regulation; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism* / Q000473:pathology; D013315:Stress, Psychological / Q000378:metabolism* / Q000473:pathology; D014667:Vasopressins / Q000096:biosynthesis*
chemical_list: D014667:Vasopressins; D003346:Corticotropin-Releasing Hormone