title: Orally administered hyaluronan affects skin dryness and epidermal thickening in photoaged hairless mice.
abstract: The oral administration of hyaluronans (HAs) (molecular weight, 300k and less than 10k) to photoaged hairless mice increased the moisture content of the stratum corneum and decreased the epidermal thickness, respectively. Furthermore, orally administered HAs suppressed the low-molecular weight of HA content of the skin. This study indicates oral administered HAs may ameliorate the skin condition resulting from photoaging.
authors.affiliation: a R&D Division , Kewpie Corporation , Chofu-shi, Tokyo , Japan.
authors.forename: Chinatsu
authors.initials: C
authors.lastname: Kawada
authors.affiliation: a R&D Division , Kewpie Corporation , Chofu-shi, Tokyo , Japan.|b Laboratory of Applied Protein Chemistry, Faculty of Agriculture , Tokyo University of Agriculture and Technology , Fuchu-shi, Tokyo , Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kimura
authors.affiliation: a R&D Division , Kewpie Corporation , Chofu-shi, Tokyo , Japan.
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Masuda
authors.affiliation: b Laboratory of Applied Protein Chemistry, Faculty of Agriculture , Tokyo University of Agriculture and Technology , Fuchu-shi, Tokyo , Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nomura
mesh_terms: D000284:Administration, Oral; D000818:Animals; D006820:Hyaluronic Acid / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D008970:Molecular Weight; D012867:Skin / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D013473:Sunscreening Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D013473:Sunscreening Agents; D006820:Hyaluronic Acid
keywords: epidermal thickening; hyaluronan; moisture content of stratum corneum; photoaging; ultraviolet irradiation