title: [Relationship between gene polymorphisms of tumor necrosis factor-α-308 and phenotypes of acute exacerbation of chronic obstructive pulmonary diseases].
abstract: OBJECTIVE
  To observe the relationship between gene polymorphisms of tumor necrosis factor-α (TNF-α)-308 and phenotypes of acute exacerbation of chronic obstructive pulmonary diseases (AECOPD).
  
  
  METHODS
  198 AECOPD cases in the Minhang Hospital of Shanghai were recruited into the patient group, and 195 healthy people were recruited into the control group. PCR and sequencing method were used to detect the polymorphism of TNF-α-308 in all the people.
  
  
  RESULTS
  Three genotypes with GG, GA and AA were detected in the 2 groups. The frequencies of GG/GA/AA genotype in AECOPD group were 87.4%, 10.6% and 2.0% respectively, and the control group were 95.4%, 4.6% and 0 respectively. The differences of the genotypes between AECOPD and health control were statistically significant (P<0.05). The frequencies of G and A were 92.7% and 7.3% in the AECOPD group, 97.7% and 2.3% in the control group. The differences were statistically significant (P<0.05). Dyspnea, smoke index and the increased thickness of bronchial wall in lung HRCT were the clinical features in patients with the TNF-α-308 genotype of GA/AA.
  
  
  CONCLUSIONS
  There is correlation between genetic predisposition of AECOPD and TNF-α-308 genotype of GA/ AA. Clinical dyspnea, smoke index and increased thickness of bronchial wall are the chief clinical features in patients with genotype of GA/AA.
authors.affiliation: Department of Respiratory Medicine, Minhang Hospital, Fudan University, Shanghai 201199, China.
authors.forename: Suyun
authors.initials: S
authors.lastname: Yu
authors.forename: Xiwen
authors.initials: X
authors.lastname: Gao
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Yan
mesh_terms: D016022:Case-Control Studies; D002681:China; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008168:Lung / Q000473:pathology; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha