title: [Association between life style, diet intake and high risk-human papillomavirus persistent infection among rural women in Xinmi City, Henan Province].
abstract: OBJECTIVE
  To explore the association between life style, diet intake and high risk human papillomavirus (HR-HPV) persistent infection among Chinese rural women living in Xinmi City, Henan Province.
  
  
  METHODS
  In 2010, a 3-year prospective study in which 2500 women were enrolled and screened by different HR-HPV DNA tests was conducted, part of women among them was followed and tested for HR-HPV DNA in 2012 and 2014. Furthermore, socio demographic factors, gynecological information and diet intake in the past 12 months were collected by self-designed questionnaire in 2014. A total of 721 women with complete test results were eligible for the final analysis. Study participants were divided into 3 groups (persistent infection group, transient infection group, and negative group) by HR-HPV status, and the association between life style, diet intake and HR-HPV persistence was evaluated using ordinal logistic regression model.
  
  
  RESULTS
  The average age of 721 women included in the analysis was 50 years old. 141 women had HR-HPV persistent infection, 180 women had HR-HPV transient infection, and 400 women were negative for HR-HPV in 3 years. Age (Χ2 = 58.449, P < 0.001, P(trend) < 0.001), smoking (Χ2 = 6.981, P = 0.021), contraception method (Χ2 = 8.448, P = 0.015) , menopause (Χ2 = 35.712, P < 0.001), number of live births (Χ2 = 16.340, P < 0.001, P(trend) < 0.001), and the intake frequency of cereals (Χ2 = 17.937, P = 0.001) or others (Χ2 = 12.107, P = 0.017) varied significantly between women grouped by different HR-HPV status. Compared to women who were older than 59 years, women in the younger groups had a much lower risk of HR-HPV persistence (adjusted OR1 = 0.39, 95% CI 0.26 - 0.59, OR2 = 0.40, 95% CI 0.23 - 0.69, and OR3 = 0.28, 95% CI 0.12 - 0.68).
  
  
  CONCLUSIONS
  Age is the main risk factor of HR-HPV persistent infection. Lifestyle, diet intake do not associate with HR-HPV persistence after adjustment by age.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Lei
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Lulu
authors.initials: L
authors.lastname: Yu
authors.forename: Zeni
authors.initials: Z
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Qin
authors.lastname: Gao Guoqi
authors.forename: Fengxian
authors.initials: F
authors.lastname: Zheng
authors.forename: Caihong
authors.initials: C
authors.lastname: Li
authors.forename: Xuemei
authors.initials: X
authors.lastname: Lian
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000032:analysis; D004032:Diet; D005260:Female; D006801:Humans; D008019:Life Style; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000208:ethnology* / Q000821:virology; D011446:Prospective Studies; D012307:Risk Factors; D012424:Rural Population
chemical_list: D004279:DNA, Viral