title: In situ monitoring of vapour-induced assembly of pharmaceutical cocrystals using a benchtop powder X-ray diffractometer.
abstract: We describe a simple setup for in situ continuous monitoring of vapour-induced transformations of organic solids using a benchtop powder X-ray diffractometer. Proof-of-principle application of this setup to model pharmaceutical cocrystals reveals complex reactivity, transformations of reaction intermediates within minutes, and a simple route to the rarely observed monoclinic form of the pharmaceutical cocrystal of carbamazepine and saccharin.
authors.affiliation: Department of Chemistry, McGill University, 801 Sherbrooke St. W. H3A 0B8, Montreal, Canada. tomislav.friscic@mcgill.ca.
authors.forename: Igor
authors.initials: I
authors.lastname: Huskić
authors.forename: Jan-Constantin
authors.initials: JC
authors.lastname: Christopherson
authors.forename: Krunoslav
authors.initials: K
authors.lastname: Užarević
authors.forename: Tomislav
authors.initials: T
authors.lastname: Friščić
mesh_terms: D003460:Crystallization; D004867:Equipment Design; D008958:Models, Molecular; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D033362:Powder Diffraction / Q000295:instrumentation* / Q000379:methods; D014835:Volatilization; D014961:X-Ray Diffraction / Q000295:instrumentation* / Q000379:methods
chemical_list: D004364:Pharmaceutical Preparations