title: Squamous-cell carcinoma in situ.
abstract: We present a 30-year-old woman with atopic dermatitis and ichthyosis vulgaris and a one-year history of an erythematous, scaly plaque on the dorsal surface of her right hand, which developed three years after an accidental exposure to prolonged ultraviolet C (UVC) radiation in a laboratory accident. The plaque, which was initially treated as eczematous dermatitis, was eventually identified histopathologically as squamous-cell carcinoma in situ. Although causation is not definitive, this case is the first to describe development of non-melanoma skin cancer (NMSC) in an area of skin known to be acutely exposed to UVC radiation. As UVC radiation becomes a more frequently used anti-microbial technology, UVC radiation may become a more commonly identified risk factor in the development of NMSC.
authors.affiliation: New York University School of Medicine.
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Rothman
authors.forename: Adnan
authors.initials: A
authors.lastname: Mir
authors.forename: Shane A
authors.initials: SA
authors.lastname: Meehan
authors.forename: Wendy Long
authors.initials: WL
authors.lastname: Mitchell
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000209:etiology / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D012867:Skin / Q000473:pathology* / Q000528:radiation effects; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology*; D014466:Ultraviolet Rays / Q000009:adverse effects*