title: Primary Cutaneous Aspergillosis in a Preterm Infant.
abstract: Primary cutaneous aspergillosis is rare in premature infants. It requires combined medical and surgical strategies. Liposomal amphotericin B is recommended as first-line therapy, but salvage regimens with others antifungal agents, such as voriconazole, have been reported. Voriconazole's pharmacodynamics is unknown in this population. We report a case of severe toxicity to voriconazole in a preterm patient with primary cutaneous aspergillosis.
authors.affiliation: From the *Pediatric Infectious Diseases and Immunodeficiencies Unit, †Neonatology Department, ‡Microbiology Department, and §Preventive Medicine and Epidemiology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: Marie Antoinette
authors.initials: MA
authors.lastname: Frick
authors.forename: Hector
authors.initials: H
authors.lastname: Boix
authors.forename: Fátima
authors.initials: F
authors.lastname: Camba Longueira
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Martin-Gomez
authors.forename: José Ángel
authors.initials: JÁ
authors.lastname: Rodrigo-Pendás
authors.forename: Pere
authors.initials: P
authors.lastname: Soler-Palacin
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001228:Aspergillosis / Q000188:drug therapy*; D003881:Dermatomycoses / Q000188:drug therapy*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis* / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009102:Multiple Organ Failure; D065819:Voriconazole / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000935:Antifungal Agents; D065819:Voriconazole