title: Managing the female patient with hereditary angioedema.
abstract: Hereditary angioedema (HAE) is a rare disorder resulting from decreased functional levels of C1-inhibitor (C1-INH), which manifests as periodic episodes of localized edema which can be extremely painful, debilitating and even fatal if the swelling affects the larynx. HAE can complicate many aspects of obstetric/gynecologic care, and an awareness of the disease is critical for clinicians involved in the care of women because of potential HAE-related complications pertaining to pregnancy, labor and delivery, and other women's health issues. This article provides a review of published literature specific to HAE and its management in female patients, including important concerns regarding obstetric/gynecologic care. A growing body of relevant experience is presented to help guide the care of women with HAE.
authors.affiliation: Massachusetts General Hospital, Cox 201, 55 Fruit Street, Boston, MA, USA.
authors.forename: Aleena
authors.initials: A
authors.lastname: Banerji
authors.affiliation: University of California, San Diego, La Jolla, CA, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Riedl
mesh_terms: D054179:Angioedemas, Hereditary / Q000188:drug therapy* / Q000517:prevention & control; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D003174:Complement C1 Inactivator Proteins / Q000627:therapeutic use*; D050718:Complement C1 Inhibitor Protein; D019468:Disease Management; D005260:Female; D006801:Humans
chemical_list: D000933:Antifibrinolytic Agents; D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; C469952:SERPING1 protein, human
keywords: C1-inhibitor; ecallantide; hereditary angioedema; icatibant; women