title: Metabolic reprogramming of pyruvate dehydrogenase is essential for the proliferation of glioma cells expressing mutant IDH1.
abstract: Mutations in isocitrate dehydrogenase 1 (IDH1) characterize most adult low-grade gliomas. Mutant IDH1 catalyzes production of the oncometabolite 2-hydroxyglutarate (2-HG). We recently discovered that theIDH1mutation also reprograms pyruvate metabolism in a 2-HG-dependent manner, and reprogramming of pyruvate metabolism is essential for cell proliferation in mutant IDH1 glioma cells.
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street San Francisco 94143, CA, USA.
authors.forename: Pavithra
authors.initials: P
authors.lastname: Viswanath
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street San Francisco 94143, CA, USA.
authors.forename: Sabrina M
authors.initials: SM
authors.lastname: Ronen
keywords: 2-HG; IDH1; gliomas; metabolic reprogramming; pyruvate dehydrogenase