title: [Metastasis revealing malignant peritoneum mesothelioma: About the difficulty to identify the primary tumors].
abstract: Peritoneal malignant mesothelioma is a rare and extremely aggressive tumor that is sometimes difficult to diagnose. We report two cases of metastatic malignant peritoneal mesothelioma. In one case, malignant metastatic cells were identified in cervical lymph nodes while in the other case, the cells were found in the liver. In both cases, metastases were identified before discovering the primary tumor. This led to the misdiagnosis of carcinoma of unknown origin. Nevertheless, the histological and immuno-histochemical patterns were typical of malignant mesothelioma. Regarding metastasis of unknown origin, a differentiation of epithelioid peritoneal malignant mesothelioma and adenocarcinoma proved to be difficult. Therefore, we discuss the diagnostic usefulness of immuno-histochemical mesothelioma markers.
authors.affiliation: Service de pathologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France.
authors.forename: Charles-Henri
authors.initials: CH
authors.lastname: Bretagne
authors.affiliation: Besançon pathologie, 16, rue Professeur-Paul-Milleret CS 51369 25006 Besançon cedex, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Petitjean
authors.affiliation: Service de pathologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Felix
authors.affiliation: Service de pathologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bedgedjian
authors.affiliation: Service de pathologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France.
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Algros
authors.affiliation: Service de radiologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France; Université de Franche-Comté, 25000 Besançon, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Delabrousse
authors.affiliation: Service de pathologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France; Université de Franche-Comté, 25000 Besançon, France. Electronic address: svalmary@univ-fcomte.fr.
authors.forename: Séverine
authors.initials: S
authors.lastname: Valmary-Degano
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D064032:Calbindin 2 / Q000032:analysis; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary*; D008207:Lymphatic Metastasis; D008654:Mesothelioma / Q000737:chemistry / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary*; D000086002:Mesothelioma, Malignant; D008889:Military Personnel; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis; D016273:Occupational Exposure; D009852:Omentum / Q000473:pathology; D010532:Peritoneal Diseases / Q000175:diagnosis; D010534:Peritoneal Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; C576764:CALB2 protein, human; D064032:Calbindin 2
keywords: Epithelioid mesothelioma; Expert network; Malignant peritonel mesothelioma; Metastasis; Mésothéliome malin péritonéal; Mésothéliome épithélioïde; Métastases; RENA-PATH; Réseau d’expert