title: Spontaneous Splenic Rupture Following Intravenous Thrombolysis with Alteplase Applied as Stroke Therapy - Case Report and Review of Literature.
abstract: BACKGROUND
  Stroke is a medical emergency in neurology, and is one of the leading causes of death nowadays. At a recent time, a therapeutic method used in adequate conditions is thrombolysis, a treatment of an emerging clot in the brain vascular system by alteplase. The application of alteplase also has a high risk of life threatening conditions.
  
  
  METHODS
  This is a brief report of a case with thrombolysis complication which manifested as a spleen rupture.
authors.affiliation: Department of Neurology, General Hospital Sibenik, Sibenik, Croatia.
authors.forename: Anka
authors.initials: A
authors.lastname: Aleksic-Shihabi
authors.affiliation: Department of Neurology, University Hospital Center Split, Split, Croatia.
authors.forename: Eni
authors.initials: E
authors.lastname: Jadrijevic
authors.affiliation: Department of Neurology, General Hospital Sibenik, Sibenik, Croatia.
authors.forename: Nina
authors.initials: N
authors.lastname: Milekic
authors.affiliation: Department of Neurology, University Hospital Center Split, Split, Croatia.
authors.forename: Ana Repic
authors.initials: AR
authors.lastname: Bulicic
authors.affiliation: Department of Neurology, University Hospital Center Split, Split, Croatia.
authors.forename: Marina
authors.initials: M
authors.lastname: Titlic
authors.affiliation: Department of Neurology, Sarajevo University Clinical Center, Sarajevo, Bosnia and Herzegovina.
authors.forename: Enra
authors.initials: E
authors.lastname: Suljic
mesh_terms: D061605:Administration, Intravenous; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D012422:Rupture, Spontaneous; D013156:Splenectomy; D013161:Splenic Rupture / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000601:surgery; D020521:Stroke / Q000188:drug therapy; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: Spleen rupture; Stroke; Thrombolysis