title: Methotrexate-induced necrolysis in tumoral-stage mycosis fungoides: a challenging diagnosis.
abstract: Methotrexate-induced cutaneous ulceration is a rare but potentially serious drug adverse reaction. This adverse reaction of methotrexate therapy has been initially described in psoriasis patients and is unusual in patients with cutaneous T-cell lymphoma. In 1978, Mc Donald et al reported the first three cases of cutaneous ulcerations in patients treated for a mycosis fungoides with intravenous infusions of methotrexate. Since then, few cases of methotrexate-induced skin ulcers in patients with mycosis fungoides have been published. We report an additional patient with erythrodermic mycosis fungoides who developed cutaneous ulcerations as a sole manifestation of methotrexate toxicity.
authors.affiliation: La Rabta Hospital.
authors.forename: Amira Ben
authors.initials: AB
authors.lastname: Mna
authors.forename: Asmahene
authors.initials: A
authors.lastname: Souissi
authors.forename: Slim
authors.initials: S
authors.lastname: Halouani
authors.forename: Dalenda
authors.initials: D
authors.lastname: El Euch
authors.forename: Alia
authors.initials: A
authors.lastname: Zahani
authors.forename: Nidham
authors.initials: N
authors.lastname: Kchir
authors.forename: Ines
authors.initials: I
authors.lastname: Zaraa
authors.forename: Mourad
authors.initials: M
authors.lastname: Mokni
mesh_terms: D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000139:chemically induced* / Q000175:diagnosis; D009367:Neoplasm Staging; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D008727:Methotrexate