title: An association and meta-analysis study of 4 SNPs from beta-2 adrenergic receptor (ADRB2) gene with risk of asthma in children.
abstract: BACKGROUND
  Although various case-control studies have been conducted to investigate the relationship between ADRB2 gene polymorphisms and asthma risk in different population groups, the results have been conflicting and inconclusive.
  
  
  OBJECTIVE
  We performed a case-control study to investigate the association of 4 SNPs in the ADRB2 gene with risk of asthma in children, and then conducted a meta-analysis by combining the previous studies.
  
  
  METHODS
  A total of 340 patients and 340 age-matched healthy controls were recruited. All of the subjects were genotyped using the PCR-based invader assay. The case-control study was performed to define the contribution of rs1042713, rs1042714, rs1800888, and rs1042711 to the predisposition of asthma. Additionally, we further conducted a meta-analysis of the study findings together with those of previously reported studies.
  
  
  RESULTS
  No significant association was found between the polymorphisms rs1042713, rs1042714, rs1800888, and rs1042711 and asthma in the current case-control study. The meta-analysis confirmed that there was no positive association of these SNPs with asthma in children in Asia, South America, Europe and the overall population.
  
  
  CONCLUSIONS
  None of the four polymorphisms in ADRB2 gene were associated with a risk of asthma in a current children population.
authors.affiliation: Department of Pediatrics, The Affiliated Hospital of Qingdao University, No.1677 Wutaishan Road, Kaifa District, Qingdao, Shan dong Province, 266555, China.
authors.forename: Xingqing
authors.initials: X
authors.lastname: Guo
authors.forename: Hongying
authors.initials: H
authors.lastname: Zheng
authors.forename: Chenggang
authors.initials: C
authors.lastname: Mao
authors.forename: Enben
authors.initials: E
authors.lastname: Guan
authors.forename: Hui
authors.initials: H
authors.lastname: Si
mesh_terms: D001249:Asthma / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012306:Risk
chemical_list: C553443:ADRB2 protein, human; D018343:Receptors, Adrenergic, beta-2