title: Light - Instead of UV Protection: New Requirements for Skin Cancer Prevention.
abstract: The requirements on sunscreens have essentially changed, since some years ago it was demonstrated that approximately 50% of free radicals, that are formed in the skin by solar radiation, originate from the visible and infrared regions of the solar spectrum. In addition, a critical radical concentration threshold could be found. If this concentration, the free radical threshold value (FRTV), is exceeded, sunburn, immunosuppression and skin cancer may develop. Application of sunscreens and lotions protects against sunburn in the UV region of the solar spectrum and therefore is frequently used to extend people's stay in the sun. However, this behaviour can enhance the concentration of free radicals formed in the visible and infrared regions of the solar spectrum, so that the critical radical threshold is exceeded and the skin may be damaged.
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Berlin, Germany leonhard.zastrow@gmail.com.
authors.forename: Leonhard
authors.initials: L
authors.lastname: Zastrow
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Berlin, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Lademann
mesh_terms: D005609:Free Radicals / Q000009:adverse effects; D006801:Humans; D012867:Skin / Q000528:radiation effects; D012878:Skin Neoplasms / Q000517:prevention & control*; D013471:Sunburn / Q000517:prevention & control*; D013472:Sunlight / Q000009:adverse effects*; D013473:Sunscreening Agents / Q000009:adverse effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D005609:Free Radicals; D013473:Sunscreening Agents
keywords: Sun radiation; antioxidants; free radical threshold value; free radicals; review; skin protection; sunscreens; visible and infrared light