title: Cardiac sympathetic denervation for intractable ventricular arrhythmias in Chagas disease.
abstract: Autonomic modulation is a valuable therapeutic option for the management of ventricular arrhythmias. Bilateral cardiac sympathetic denervation (BCSD) has shown promising results in the acute, intermediate, and long-term management of polymorphic and monomorphic ventricular tachycardia (VT) in patients with structural heart disease. Cardiomyopathy (CM) due to Chagas disease (CD), and associated VT, is thought to be in part due to autonomic neuronal destruction and dysfunction.
  
  
  
  The purpose of this study was to assess whether BCSD is a safe and effective treatment modality in patients with CD and VT storm or refractory VT.
  
  
  
  A retrospective analysis of data from patients with chagasic CM who underwent BCSD between 2009 and 2015 at 2 international centers was performed.
  
  
  
  Of 75 patients who underwent BCSD for VT storm or refractory VT in the setting of CM, 7 (9.3%) patients had CD as the etiology of CM. All patients had monomorphic VT. Median follow-up was 7 months (range 1-46 months). All patients either underwent previous unsuccessful catheter ablation or were not candidates for ablation. The median number of implantable cardioverter-defibrillator (ICD) shocks 1 month before BCSD was 4 (range 2-30) and decreased to 0 (range 0-2) during available follow-up after BCSD. When antitachycardia pacing therapies were included in the analysis, the median number of ICD therapies (shocks + antitachycardia pacing) still decreased to 1 (range 0-3).
  
  
  
  In patients with chagasic CM presenting with refractory monomorphic VT, early evidence suggests that BCSD reduces appropriate ICD therapy and may represent a valuable treatment option.
authors.affiliation: International Arrhythmia Center, Cardioinfantil Foundation, Bogota, Colombia.
authors.forename: Luis Carlos
authors.initials: LC
authors.lastname: Saenz
authors.affiliation: International Arrhythmia Center, Cardioinfantil Foundation, Bogota, Colombia.
authors.forename: Federico Malavassi
authors.initials: FM
authors.lastname: Corrales
authors.affiliation: International Arrhythmia Center, Cardioinfantil Foundation, Bogota, Colombia.
authors.forename: William
authors.initials: W
authors.lastname: Bautista
authors.affiliation: Olive View-UCLA Center of Excellence for Chagas Disease, Sylmar, California.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Traina
authors.affiliation: Olive View-UCLA Center of Excellence for Chagas Disease, Sylmar, California.
authors.forename: Sheba
authors.initials: S
authors.lastname: Meymandi
authors.affiliation: International Arrhythmia Center, Cardioinfantil Foundation, Bogota, Colombia.
authors.forename: Diego A
authors.initials: DA
authors.lastname: Rodriguez
authors.affiliation: International Arrhythmia Center, Cardioinfantil Foundation, Bogota, Colombia.
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Tellez
authors.affiliation: UCLA Cardiac Arrhythmia Center, UCLA Neurocardiology Research Center of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: Marmar
authors.initials: M
authors.lastname: Vaseghi
authors.affiliation: International Arrhythmia Center, Cardioinfantil Foundation, Bogota, Colombia; Division of Cardiology, Section of Electrophysiology, University of Pennsylvania Health System and School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Fermin
authors.initials: F
authors.lastname: Garcia
authors.affiliation: UCLA Cardiac Arrhythmia Center, UCLA Neurocardiology Research Center of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: Kalyanam
authors.initials: K
authors.lastname: Shivkumar
authors.affiliation: Olive View-UCLA Center of Excellence for Chagas Disease, Sylmar, California; UCLA Cardiac Arrhythmia Center, UCLA Neurocardiology Research Center of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, California,. Electronic address: JBradfield@mednet.ucla.edu.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Bradfield
mesh_terms: D002140:California / Q000453:epidemiology; D002598:Chagas Cardiomyopathy / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D003105:Colombia / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D013562:Sympathectomy / Q000009:adverse effects / Q000379:methods; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D016896:Treatment Outcome
keywords: Ablation; Autonomic; Chagas disease; ICD therapy; Sympathetic; Ventricular tachycardia