title: Germ Line Mechanics--And Unfinished Business.
abstract: Primordial germ cells are usually made early in the development of an organism. These are the mother of all stem cells that are necessary for propagation of the species, yet use highly diverse mechanisms between organisms. How they are specified, and when and where they form, are central to developmental biology. Using diverse organisms to study this development is illuminating for understanding the mechanics these cells use in this essential function and for identifying the breadth of evolutionary changes that have occurred between species. This essay emphasizes how echinoderms may contribute to the patchwork quilt of our understanding of germ line formation during embryogenesis.
authors.affiliation: Department of Molecular and Cellular Biology, Brown University, Providence, Rhode Island, USA. Electronic address: rhet@brown.edu.
authors.forename: Gary M
authors.initials: GM
authors.lastname: Wessel
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004447:Echinodermata / Q000235:genetics / Q000254:growth & development*; D004625:Embryo, Nonmammalian / Q000166:cytology*; D047108:Embryonic Development / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000166:cytology* / Q000378:metabolism
keywords: Gametes; Germ line; Nanos; Sea urchin; Vasa