title: [Molecular biology of familial cases of human melanoma].
abstract: Skin melanoma is an etiologically heterogeneous disease, the development of which is related to a complex interaction of environmental factors and individual genetic characteristics. This article provides current molecular-genetic aspects of familial cases of melanoma and polymorphism of genes directly related to the risk of developing this hereditary disease. The studies of hereditary cancer cases add our knowledge of mechanisms oncotransformation, genetic changes in signaling pathways, which are responsible for invasiveness, metastasis and drug resistance of melanoma cells of the skin.
authors.forename: O I
authors.initials: OI
authors.lastname: Kit
authors.forename: D L
authors.initials: DL
authors.lastname: Vodolazhsky
authors.forename: N N
authors.initials: NN
authors.lastname: Timoshkina
authors.forename: Yu V
authors.initials: YV
authors.lastname: Przhedetsky
authors.forename: O V
authors.initials: OV
authors.lastname: Khokhlova
mesh_terms: D051358:Cyclin-Dependent Kinase 4 / Q000235:genetics*; D059647:Gene-Environment Interaction; D019942:Genes, p16; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008545:Melanoma / Q000209:etiology / Q000235:genetics*; D051739:Microphthalmia-Associated Transcription Factor / Q000235:genetics*; D009154:Mutation; D027384:Oncogene Proteins v-raf / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D044102:Receptor, Melanocortin, Type 1 / Q000235:genetics*; D012878:Skin Neoplasms / Q000209:etiology / Q000235:genetics*; D014983:Xeroderma Pigmentosum / Q000235:genetics; D000096142:Cutaneous Malignant Melanoma
chemical_list: C497234:MITF protein, human; D051739:Microphthalmia-Associated Transcription Factor; D044102:Receptor, Melanocortin, Type 1; C482119:BRAF protein, human; D027384:Oncogene Proteins v-raf; D048493:Proto-Oncogene Proteins B-raf; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4