title: Metabolic comorbidities and hypertension in psoriasis patients in France. Comparisons with French national databases.
abstract: BACKGROUND
  Several studies have shown a high prevalence of cardiovascular and metabolic comorbidities in psoriasis. Our study aimed to evaluate the association of psoriasis with key comorbidities such as smoking, obesity, hypertension, dyslipidaemia and diabetes comparatively with French national data.
  
  
  METHODS
  This multicentre noninterventional observational study of adults with psoriasis was conducted in 29 dermatology centres in France. A total of 2210 patients were included. The prevalence of comorbidities in psoriatic patients was compared to data from the French national databanks "ObEpi 2012" (obesity, hypertension, dyslipidaemia and diabetes) and "Baromètre Santé 2010" (smoking).
  
  
  RESULTS
  We reported a higher prevalence of all metabolic comorbidities and high blood pressure in psoriatic patients. Smoking: 32.5% were active smokers; the age of onset and the prevalence of familial psoriasis were significantly lower in the smoking group but the severity of psoriasis was significantly higher. The frequency of smoking was higher than in the general population, particularly among young female patients. Obesity: 24% of patients with psoriasis were obese. Multivariate analysis showed obesity to be significantly associated with other comorbidities, severity of psoriasis and psoriatic arthritis. The incidence of obesity was higher than in general population, occurring chiefly in subjects aged over 45 years.
  
  
  RESULTS
  26% of patients with psoriasis had hypertension. The age of onset of psoriasis and the prevalence of psoriatic arthritis were significantly higher in the hypertension group, although there was less familial psoriasis. The incidence of hypertension was higher than in general population. Dyslipidaemia: 27.5% of patients with psoriasis had dyslipidaemia. The age of onset in the dyslipidaemia group was higher although there was less familial psoriasis. The incidence of dyslipidaemia was higher than in general population. Diabetes: 11.0% of patients with psoriasis had diabetes. The age of onset of psoriasis was significantly higher in the diabetes group although there was less familial psoriasis. The incidence of diabetes was higher than in general population particularly after the age of 35 years.
  
  
  CONCLUSIONS
  These results confirmed that psoriasis is associated with significant metabolic comorbidities and hypertension compared to the general population in France, with certain epidemiological differences for each.
authors.affiliation: Department of Dermatology, centre hospitalier Victor-Dupouy, 69, rue du Lieutenant-Colonel-Prud'hon, 95107 Argenteuil cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Phan
authors.affiliation: Department of Dermatology, centre hospitalier Victor-Dupouy, 69, rue du Lieutenant-Colonel-Prud'hon, 95107 Argenteuil cedex, France.
authors.forename: M-L
authors.initials: ML
authors.lastname: Sigal
authors.affiliation: Department of Dermatology, hôpital Larrey, CHU de Toulouse, université Paul-Sabatier, 31000 Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Lhafa
authors.affiliation: Department of Dermatology, centre hospitalier d'Auxerre, 89000 Auxerre, France.
authors.forename: H
authors.initials: H
authors.lastname: Barthélémy
authors.affiliation: Department of Dermatology, hôpital d'instruction des armées Bégin, 69, avenue de Paris, 94160 Saint-Mandé, France.
authors.forename: F
authors.initials: F
authors.lastname: Maccari
authors.affiliation: Department of Dermatology, centre hospitalier régional d'Orléans, 45000 Orléans, France.
authors.forename: E
authors.initials: E
authors.lastname: Estève
authors.affiliation: Department of Dermatology, hôpital Robert-Debré, 51100 Reims, France.
authors.forename: Z
authors.initials: Z
authors.lastname: Reguiai
authors.affiliation: Department of Dermatology, CHU Saint-Etienne, 42055 Saint-Étienne cedex 2, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Perrot
authors.affiliation: Department of Dermatology, hôpital Sud, avenue Laënnec, 80054 Amiens cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Chaby
authors.affiliation: Department of Dermatology, centre hospitalier du Mans, 72000 Le Mans, France.
authors.forename: H
authors.initials: H
authors.lastname: Maillard
authors.affiliation: Department of Dermatology, hôpital de Pontoise, 95000 Pontoise, France.
authors.forename: E
authors.initials: E
authors.lastname: Bégon
authors.affiliation: Department of Dermatology, CHU Avicennes, 125, rue de Stalingrad, 93009 Bobigny, France.
authors.forename: M
authors.initials: M
authors.lastname: Alexandre
authors.affiliation: Centre de diagnostic et traitement des plaies chroniques, hôpital Bagatelle, 201, rue Robespierre, BP 50048, 33401 Talence cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Toussaint
authors.affiliation: Department of Dermatology, 5, avenue du Président-Wilson, 94340 Joinville-Le-Pont, France.
authors.forename: M
authors.initials: M
authors.lastname: Bastien-Jacquin
authors.affiliation: Department of Dermatology, groupe hospitalier du Havre, 47, rue de Tourneville, 76600 Havre, France.
authors.forename: P
authors.initials: P
authors.lastname: Bravard
authors.affiliation: Private Dermatology Practice, 116, rue Dalayrac, 94120 Fontenay-sous-Bois, France.
authors.forename: E
authors.initials: E
authors.lastname: Sauque
authors.affiliation: Department of Dermatology, centre hospitalier de la région d'Annecy, 1, avenue de l'Hôpital, 74370 Metz-Tessy, France.
authors.forename: J
authors.initials: J
authors.lastname: de Quatrebarbes
authors.affiliation: Private Dermatology Practice, 6, rue Lamblardie, 75012 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Pfister
authors.affiliation: Department of Public Health, CHU Ambroise-Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92104 Boulogne-Billancourt cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Beauchet
authors.affiliation: Department of Dermatology, centre hospitalier Victor-Dupouy, 69, rue du Lieutenant-Colonel-Prud'hon, 95107 Argenteuil cedex, France. Electronic address: emmanuel.mahe@ch-argenteuil.fr.
authors.forename: E
authors.initials: E
authors.lastname: Mahé
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D015897:Comorbidity; D003430:Cross-Sectional Studies; D016208:Databases, Factual; D003920:Diabetes Mellitus / Q000453:epidemiology; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008297:Male; D008659:Metabolic Diseases / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D018579:Patient Selection; D015995:Prevalence; D011565:Psoriasis / Q000453:epidemiology* / Q000235:genetics; D012907:Smoking / Q000453:epidemiology
keywords: Comorbidities; Comorbidités; Diabetes mellitus; Diabète; Dyslipidaemia; Dyslipidémie; Hypertension; Hypertension artérielle; Obesity; Obésité; Psoriasis; Smoking; Tabagisme