title: S1PR2 deficiency in DLBCL: a FOXy connection.
abstract: Inactivating mutations in the sphingosine-1-phosphate (S1P) receptor 2 (S1PR2) promoter have been associated with the germinal center (GC) B-cell diffuse large B-cell lymphoma (GCB-DLBCL) subtype. In this issue of Blood, Flori et al have now identified S1PR2 as a tumor suppressor that is transcriptionally silenced by forkhead box protein 1 (FOXP1) in the aggressive, activated B-cell (ABC-DLBCL) subtype.
authors.affiliation: UNIVERSITY OF SIENA.
authors.forename: Cosima T
authors.identifier: http://orcid.org/0000-0002-4414-6744
authors.initials: CT
authors.lastname: Baldari
mesh_terms: D000818:Animals; D051858:Forkhead Transcription Factors / Q000502:physiology*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D009363:Neoplasm Proteins / Q000502:physiology*; D049349:Receptors, Lysosphingolipid / Q000502:physiology*; D012097:Repressor Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D051858:Forkhead Transcription Factors; D009363:Neoplasm Proteins; D049349:Receptors, Lysosphingolipid; D012097:Repressor Proteins