title: ROS and intracellular ion channels.
abstract: Oxidative stress is a well-known driver of numerous pathological processes involving protein and lipid peroxidation and DNA damage. The resulting increase of pro-apoptotic pressure drives tissue damage in a host of conditions, including ischemic stroke and reperfusion injury, diabetes, death in acute pancreatitis and neurodegenerative diseases. Somewhat less frequently discussed, but arguably as important, is the signaling function of oxidative stress stemming from the ability of oxidative stress to modulate ion channel activity. The evidence for the modulation of the intracellular ion channels and transporters by oxidative stress is constantly emerging and such evidence suggests new regulatory and pathological circuits that can be explored towards new treatments for diseases in which oxidative stress is an issue. In this review we summarize the current knowledge on the effects of oxidative stress on the intracellular ion channels and transporters and their role in cell function.
authors.affiliation: Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, United States; Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch NIH, NIDCR, Bethesda, MD 20892, United States. Electronic address: kiselyov@pitt.edu.
authors.forename: Kirill
authors.initials: K
authors.lastname: Kiselyov
authors.affiliation: Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, United States; Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch NIH, NIDCR, Bethesda, MD 20892, United States. Electronic address: shmuel.muallem@nih.gov.
authors.forename: Shmuel
authors.initials: S
authors.lastname: Muallem
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*; D017136:Ion Transport; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological
chemical_list: D007473:Ion Channels; D002118:Calcium
keywords: Calcium; Endoplasmic reticulum; Ion channels; Lysosomes; Oxidative stress; Reactive oxygen species; Transition metals