title: Antimicrobial Metabolites from a Marine-Derived Actinomycete in Vietnam's East Sea.
abstract: Two new compounds, a quinoline alkaloid (1) and a 1,4-dioxane derivative (2), were isolated from culture broth of the marine-derived actinomycete Micromonospora sp. (strain G019) by bioassay-guided fractionation. This actinomycete strain was isolated from sediment, collected at Cát Bà Peninsula, Vietnam. The taxonomic identification was achieved by analysis of 16S rRNA gene sequences. On the basis of morphological and phylogenetic evidence, strain G019 was assigned to the genus Micromonospora. The structures of 1 and 2 were established by spectroscopic data analysis, including one- and two-dimensional NMR, and MS. Compound 1 was found to have antibacterial activity against Escherichia coli (MIC: 48 µg/mL), Salmonella enterica (MIC: 96 µg/mL) and Enterococcus faecalis (MIC: 128 µg/mL), while compound 2 showed inhibitory activity against Enterococcusfaecalis (MIC: 32 µg/mL) and Candida albicans (MIC: 64 µg/mL).
authors.forename: Quyen Vu
authors.initials: QV
authors.lastname: Thi
authors.forename: Van Hieu
authors.initials: VH
authors.lastname: Tran
authors.forename: Huong Doan Thi
authors.initials: HD
authors.lastname: Maia
authors.forename: Cong Vinh
authors.initials: CV
authors.lastname: Le
authors.forename: Minh Le Thi
authors.initials: Mle T
authors.lastname: Hong
authors.forename: Brian T
authors.initials: BT
authors.lastname: Murphy
authors.forename: Van Minh
authors.initials: VM
authors.lastname: Chau
authors.forename: Van Cuong
authors.initials: VC
authors.lastname: Pham
mesh_terms: D039903:Actinobacteria / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000438:Alcohols / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000470:Alkaloids / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism*; D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004146:Dioxanes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000431:Ethanol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D019015:Geologic Sediments / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009792:Oceans and Seas; D011804:Quinolines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D014744:Vietnam
chemical_list: C000606891:2-((5-methyl-1,4-dioxan-2-yl)methoxy)ethanol; C000606889:3,4-dihydroxy-6,7-dimethyl-quinoline-2-carboxylic acid; D000438:Alcohols; D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004146:Dioxanes; D011804:Quinolines; D000431:Ethanol