title: Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release.
abstract: Magnetically-responsive nano/micro-engineered biomaterials that enable a tightly controlled, on-demand drug delivery have been developed as new types of smart soft devices for biomedical applications. Although a number of magnetically-responsive drug delivery systems have demonstrated efficacies through either in vitro proof of concept studies or in vivo preclinical applications, their use in clinical settings is still limited by their insufficient biocompatibility or biodegradability. Additionally, many of the existing platforms rely on sophisticated techniques for their fabrications. We recently demonstrated the fabrication of biodegradable, gelatin-based thermo-responsive microgel by physically entrapping poly(N-isopropylacrylamide-co-acrylamide) chains as a minor component within a three-dimensional gelatin network. In this study, we present a facile method to fabricate a biodegradable drug release platform that enables a magneto-thermally triggered drug release. This was achieved by incorporating superparamagnetic iron oxide nanoparticles and thermo-responsive polymers within gelatin-based colloidal microgels, in conjunction with an alternating magnetic field application system.
authors.affiliation: Department of Biological Sciences, Kent State University; Liquid Crystal Institute, Kent State University.
authors.forename: Baeckkyoung
authors.initials: B
authors.lastname: Sung
authors.affiliation: Department of Biological Sciences, Kent State University.
authors.forename: Steven
authors.initials: S
authors.lastname: Shaffer
authors.affiliation: Department of Biological Sciences, Kent State University.
authors.forename: Michal
authors.initials: M
authors.lastname: Sittek
authors.affiliation: Department of Biological Sciences, Kent State University.
authors.forename: Talib
authors.initials: T
authors.lastname: Alboslemy
authors.affiliation: Liquid Crystal Institute, Kent State University; Chemical Physics Interdisciplinary Program, Kent State University.
authors.forename: Chanjoong
authors.initials: C
authors.lastname: Kim
authors.affiliation: Department of Biological Sciences, Kent State University; mkim15@kent.edu.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Kim
mesh_terms: D000178:Acrylamides / Q000138:chemical synthesis; D000180:Acrylic Resins / Q000138:chemical synthesis; D001672:Biocompatible Materials / Q000138:chemical synthesis; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D003911:Dextrans / Q000138:chemical synthesis; D004337:Drug Carriers / Q000138:chemical synthesis; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005780:Gelatin / Q000138:chemical synthesis*; D005782:Gels; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles; D053768:Metal Nanoparticles / Q000737:chemistry
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D003911:Dextrans; D004337:Drug Carriers; D005782:Gels; D058185:Magnetite Nanoparticles; C469412:poly(N-isopropylacrylamide-co-acrylamide); D005780:Gelatin; C067295:N-isopropylacrylamide; C065507:ferumoxides