title: Effectiveness of degradable and non-degradable implants to close large septal perforations in an experimental model.
abstract: Background Reparation of large nasal septum perforations continues to be challenging. Bipedicled mucoperichondrial and inter-positional grafts currently show the most promising results. New implants have emerged to be used as a support membrane to carry on the mucosal cells, taking advantage of the innate proliferative properties of the mucosal tissue. Objective To compare the effectiveness of two kinds of material; non-absorbable dimethylsiloxane (silicone elastomers) and absorbable porcine small intestinal submucosa (Surgisis), both used as an inter-positional graft without neighbouring flaps to close nasal septal perforations in an experimental model. Methods Fifteen dogs were divided into three groups. One group received Surgisis, the other sheets of dimethylsiloxane and the last group a sham group. The dogs were followed for 6 weeks. Results The initial perforation of the nasal septum showed complete mucosal closure in the dimethylsiloxane group. The Surgisis group, on the other hand, had a smaller reduction than that at the beginning (final mean area = 23.0 ± 5.4 mm(2) (p < 0.05); however, complete closure was not achieved. Sham animals showed an inconstant and slight reduction in dimension from 100 mm(2) to 70 ± 16 mm(2) of mucosa and cartilage, but closure was not achieved. A significantly higher number of capillaries were observed in the Surgisis group compared to the dimethylsiloxane group (p < 0.05) without differences in inflammation, fibrosis, or necrosis. Conclusions The non-absorbable implant; dimethylsiloxane facilitates a better closure of the nasal septum.
authors.affiliation: a Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS , Universidad de Guadalajara , Guadalajara Jalisco , México.
authors.forename: Victor M
authors.initials: VM
authors.lastname: Hernández Martinez
authors.affiliation: a Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS , Universidad de Guadalajara , Guadalajara Jalisco , México.
authors.forename: Leonel
authors.initials: L
authors.lastname: Garcia Benavides
authors.affiliation: a Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS , Universidad de Guadalajara , Guadalajara Jalisco , México.
authors.forename: Sylvia E
authors.initials: SE
authors.lastname: Totsuka Sutto
authors.affiliation: a Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS , Universidad de Guadalajara , Guadalajara Jalisco , México.
authors.forename: Ernesto G
authors.initials: EG
authors.lastname: Cardona Muñoz
authors.affiliation: a Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS , Universidad de Guadalajara , Guadalajara Jalisco , México.
authors.forename: Tania Isabel
authors.initials: TI
authors.lastname: Campos Bayardo
authors.affiliation: a Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS , Universidad de Guadalajara , Guadalajara Jalisco , México.
authors.forename: Sara
authors.initials: S
authors.lastname: Pascoe Gonzalez
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D003094:Collagen; D004129:Dimethylpolysiloxanes; D004285:Dogs; D007413:Intestinal Mucosa; D023421:Models, Animal; D009297:Nasal Mucosa / Q000033:anatomy & histology; D061270:Nasal Septal Perforation / Q000601:surgery*; D009300:Nasal Septum / Q000601:surgery*; D019736:Prostheses and Implants; D012225:Rhinoplasty / Q000379:methods; D013552:Swine
chemical_list: D004129:Dimethylpolysiloxanes; C588278:surgisis; D003094:Collagen
keywords: Nasal septal perforation; porcine small intestinal submucosa; silicone elastomer; surgisis