title: C. elegans Embryonic Morphogenesis.
abstract: Morphogenesis is a four-dimensional process which involves the crucial interplay between signaling, mechanical forces, and spatial changes. Caenorhabditis elegans presents a simple yet versatile model to study morphogenesis. Here, we review recent progress on cellular and molecular drivers of morphological changes during C. elegans epiboly and embryonic elongation: actin dynamics and actomyosin contractility, migration guidance cues and junction remodeling. In addition, we discuss how mechanical forces contribute to the process.
authors.affiliation: Laboratoire de Biologie du Développement, CNRS-UMR7622, Institut de Biologie Paris-Seine, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France. Electronic address: thanh.vuong@upmc.fr.
authors.forename: Thanh T K
authors.initials: TT
authors.lastname: Vuong-Brender
authors.affiliation: Laboratoire de Biologie du Développement, CNRS-UMR7622, Institut de Biologie Paris-Seine, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Yang
authors.affiliation: Laboratoire de Biologie du Développement, CNRS-UMR7622, Institut de Biologie Paris-Seine, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France. Electronic address: michel.labouesse@upmc.fr.
authors.forename: Michel
authors.initials: M
authors.lastname: Labouesse
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000166:cytology* / Q000378:metabolism; D047108:Embryonic Development; D009024:Morphogenesis / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D029742:Caenorhabditis elegans Proteins
keywords: Actin dynamics; Actomyosin contractility; C. elegans; Cell migration; Embryonic morphogenesis; Junction remodeling; Mechanotransduction; Migration guidance; Muscle attachement