title: The IL6R gene polymorphisms are associated with sIL-6R, IgE and lung function in Chinese patients with asthma.
abstract: BACKGROUND
  sIL-6R is involved in a variety of inflammatory diseases. The present study analyzed the potential associations between two IL6R gene polymorphisms (rs2228145 and rs12083537) and asthma in a Han Chinese population.
  
  
  METHODS
  A cohort of 394 patients and 395 healthy controls were genotyped to detect the two polymorphisms using SNaPshot. In 66 asthma patients and 49 controls, peripheral eosinophil and serum immunoglobulin E (IgE) levels were determined using a routine blood test, and sIL-6R levels were measured by ELISA.
  
  
  RESULTS
  No statistically significant differences were detected between the patients and controls in the distribution of the two independent IL6R polymorphisms (p>0.05). However, rs2228145 C and rs12083537 G were significantly associated with decreased lung function in patients with asthma; the rs2228145 A-C variant was also associated with increased sIL-6R and IgE levels. In addition, sIL-6R levels were positively associated with IgE and inversely associated with lung function in patients with asthma.
  
  
  CONCLUSIONS
  Our results provide evidence that rs2228145 C and rs12083537 G are associated with poor lung function in patients with asthma. Furthermore, the rs2228145 A-C variant is associated with levels of sIL-6R and IgE.
authors.affiliation: Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR China.
authors.forename: Huiting
authors.initials: H
authors.lastname: Hu
authors.affiliation: Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.affiliation: Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR China.
authors.forename: Xuanna
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhen
authors.affiliation: Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR China.
authors.forename: Shaobing
authors.initials: S
authors.lastname: Wang
authors.affiliation: Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Liang
authors.affiliation: Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR China.. Electronic address: wubin621011@126.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.affiliation: Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR China.. Electronic address: sihan1107@126.com.
authors.forename: Guoda
authors.initials: G
authors.lastname: Ma
mesh_terms: D001249:Asthma / Q000235:genetics*; D002681:China; D004804:Eosinophils; D005260:Female; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008168:Lung / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019947:Receptors, Interleukin-6 / Q000097:blood* / Q000235:genetics*; D012129:Respiratory Function Tests
chemical_list: C508603:IL6R protein, human; D019947:Receptors, Interleukin-6; D007073:Immunoglobulin E
keywords: Asthma; IgE; Polymorphisms; Rs12083537; Rs2228145; sIL-6R