title: Dual-energy computed tomography: a promising novel preoperative localization study for treatment of primary hyperparathyroidism.
abstract: BACKGROUND
  The objective of this study was to evaluate dual-energy computed tomography (DE-CT) for preoperative parathyroid tumor (PT) localization in individuals undergoing parathyroidectomy for treatment of primary hyperparathyroidism (PHP).
  
  
  METHODS
  DE-CT was evaluated by retrospective review of the clinical and biochemical characteristics, imaging, operative findings, and outcomes for PHP cases undergoing an initial operation at a single center.
  
  
  RESULTS
  The accuracy of each preoperative imaging test, based on operative findings and pathological confirmation of removal of a PT from the localized site was: 58% for ultrasound, 75% Tc-99m sestamibi noncontrast single photon emission noncontrast CT, and 75% for DE-CT. DE-CT was able to correctly localize a PT in a 3rd of cases that were nonlocalized. All study patients had normalization of serum calcium and parathyroid hormone levels postoperatively.
  
  
  CONCLUSIONS
  DE-CT shows promise for the preoperative PT localization, especially in nonlocalized PHP cases, and warrants further investigation.
authors.affiliation: Department of Surgery, St. Paul's Hospital & University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada.
authors.forename: Nazgol
authors.initials: N
authors.lastname: Seyednejad
authors.affiliation: Department of Radiology, St. Paul's Hospital & University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Ciaran
authors.initials: C
authors.lastname: Healy
authors.affiliation: Department of Radiology, St. Paul's Hospital & University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Pari
authors.initials: P
authors.lastname: Tiwari
authors.affiliation: Department of Radiology, St. Paul's Hospital & University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Vos
authors.affiliation: Department of Nuclear Medicine, St. Paul's Hospital & University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: George
authors.initials: G
authors.lastname: Sexsmith
authors.affiliation: Department of Surgery, St. Paul's Hospital & University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada.
authors.forename: Adrienne
authors.initials: A
authors.lastname: Melck
authors.affiliation: Department of Radiology, St. Paul's Hospital & University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Cameron
authors.initials: C
authors.lastname: Hague
authors.affiliation: Department of Surgery, St. Paul's Hospital & University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada. Electronic address: smwiseman@providencehealth.bc.ca.
authors.forename: Sam M
authors.initials: SM
authors.lastname: Wiseman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001955:British Columbia; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000175:diagnosis* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D064847:Multimodal Imaging / Q000379:methods; D016105:Parathyroidectomy / Q000379:methods; D011300:Preoperative Care / Q000379:methods; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D000072098:Single Photon Emission Computed Tomography Computed Tomography / Q000379:methods*; D017256:Technetium Tc 99m Sestamibi; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler / Q000379:methods
chemical_list: D017256:Technetium Tc 99m Sestamibi
keywords: Adenoma; Dual-energy computed tomography; Parathyroid localization; Parathyroidectomy; Primary hyperparathyroidism