title: In focus: Fe3O4 nanoparticles and human mesenteric artery interaction in vitro.
abstract: OBJECTIVE
  The growing implementation of iron oxide nanoparticles in medicine requires a thorough investigation of their physiological influence. Therefore, effects of Fe3O4 nanoparticles on isometric contractions of healthy human mesenteric artery in vitro were investigated.
  
  
  METHODS
  The effect of increasing concentrations (0.023, 0.069, 0.23, 0.69 and 2.31 μg/μl) of Fe3O4 nanoparticles (50-100 nm) on the contractility of mesenteric artery ring preparations was studied using wire myography technique.
  
  
  CONCLUSIONS
  A lack of effects of Fe3O4 nanoparticles (50-100 nm) on isometric contractions of human mesenteric artery segments both in conditions of basal tension and precontraction was found. The observed unresponsiveness of human mesenteric arteries in vitro to Fe3O4 nanoparticles could be attributed to their safe mode of use in biomedicine.
authors.affiliation: Department Excitable Structures, Institute of Biophysics & Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Bldg. 21, 1113 Sofia, Bulgaria.
authors.forename: Teodora I
authors.initials: TI
authors.lastname: Vukova
authors.affiliation: Department of Anesthesiology & Intensive Care, Military Medical Academy, St. Georgi Sofyiski Street, 3, 1606 Sofia, Bulgaria.
authors.forename: Stanislav D
authors.initials: SD
authors.lastname: Dimitrov
authors.affiliation: Department of Human & Animal Physiology, Faculty of Biology, Sofia University "St. Kliment Ohridski", 8 D. Tsankov Blvd., 1164 Sofia, Bulgaria.
authors.forename: Hristo S
authors.initials: HS
authors.lastname: Gagov
authors.affiliation: Department Excitable Structures, Institute of Biophysics & Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Bldg. 21, 1113 Sofia, Bulgaria.
authors.forename: Daniela Z
authors.initials: DZ
authors.lastname: Dimitrova
mesh_terms: D005260:Female; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000032:analysis*; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000502:physiology*; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D058185:Magnetite Nanoparticles
keywords: Fe3O4 nanoparticles; artery wire myography; human mesenteric artery; in vitro; isometric artery contraction