title: Elevated Liver Enzymes in Cases of Preeclampsia and Intrauterine Growth Restriction.
abstract: OBJECTIVE
  The aim of this study was to evaluate biochemical parameters in serum of women with preeclampsia and IUGR.
  
  
  METHODS
  A clinical prospective study was conducted and included 120 pregnant women divided in two groups: non IUGR group included healthy pregnant women (n=60) and IUGR group included pregnant women with preeclampsia and IUGR (n=60). Outcome measures were following values of biochemical parameters in serum of mother and fetuses: aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), bilirubin (indirect and direct) and cholesterol. A blood for analysis was drawn from the cubital vein of mothers and the umbilical vein of the fetuses during delivery period.
  
  
  RESULTS
  The mean of maternal age was 30.0±6.1 years in women with preeclampsia and IUGR and 28.1±5.1 years in healthy pregnant women, p > 0.05. The most of women with preeclampsia and IUGR had grade III of placental maturation (48.3%). There is a significant association between the placental maturation and the diagnosis, p < 0.001. There was a statistically significant difference in body mass of newborns between IUGR and non IUGR groups, p < 0.001. There was a significant statistically difference in serum value of AST, ALT, LDH and total cholesterol between women with preeclampsia and IUGR and healthy pregnant women (all p < 0.001).
  
  
  CONCLUSIONS
  Measurement of AST, ALT, LDH, and total cholesterol in serum of pregnant women and newborns with IUGR allows the differentiation and threatening risk of perinatal complications due to hypoxia.
authors.affiliation: Department of Obstetrics and Gynecology, Regional Hospital, Pec, Republic of Kosova.
authors.forename: Ramadan
authors.initials: R
authors.lastname: Dacaj
authors.affiliation: Private Gynecological Surgery, Sarajevo, Bosnia and Herzegovina.
authors.forename: Sebija
authors.initials: S
authors.lastname: Izetbegovic
authors.affiliation: Private Gynecological Surgery, Sarajevo, Bosnia and Herzegovina.
authors.forename: Goran
authors.initials: G
authors.lastname: Stojkanovic
authors.affiliation: Department of Obstetrics and Gynecology, Regional Hospital, Pec, Republic of Kosova.
authors.forename: Skender
authors.initials: S
authors.lastname: Dreshaj
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin
keywords: Preeclampsia; biochemical parameters; intrauterine growth restriction; liver of fetus