title: [Development of Fuzi precision decoction pieces (PDP) (I): Specification and quality uniformity].
abstract: The specification of decoction pieces and quality uniformity are the important factors to influence the efficacy of clinical medicine. Considering the deficiency of diversity, poor quality uniformity and confusion of decoction pieces specifications, we first propose a new idea of precision decoction pieces (PDP) based on clinical demands and fresh-processed technology. In order to explain the idea, a study case of aconite SUP is provided, including the optimized specification design, processing technology, extraction effects, quality uniformity, and toxic and efficacy variation and so on. The results showed that preparing 5 mm PDP by fresh-cutting is rather simple and practicable, with high efficiency and large yield; then, this technology could significantly decrease the ingredients loss and increase the efficacy components; moreover, it was helpful for achieving the quality uniformity and best extraction effects. This work revealed the quality superiority of PDP, and provided a good strategy and example for the standard of decoction pieces specification and modernization of processing technology.
authors.forename: Ding-kun
authors.initials: DK
authors.lastname: Zhang
authors.forename: Xue
authors.initials: X
authors.lastname: Han
authors.forename: Yong-feng
authors.initials: YF
authors.lastname: Zhou
authors.forename: Peng
authors.initials: P
authors.lastname: Tan
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.forename: Jia-bo
authors.initials: JB
authors.lastname: Wang
authors.forename: Xiao-he
authors.initials: XH
authors.lastname: Xiao
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D010316:Particle Size; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D011786:Quality Control
chemical_list: D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C575009:fuzi drug herbal