title: Association of cytomegalovirus infection with hypertension risk: a meta-analysis.
abstract: BACKGROUND
  Information regarding association between cytomegalovirus (CMV) infection and essential hypertension (EH) risk is not consistent across studies. Therefore, we conducted a meta-analysis to investigate the association in detail.
  
  
  METHODS
  We comprehensively searched the published literature from the PubMed and Embase databases for any study analyzing the association between CMV and EH risk. A random-effects model was used to calculate the pooled odds ratio (OR) with 95 % confidence interval (CI).
  
  
  RESULTS
  Three studies involving 9657 patients were included in the meta-analysis, and the results showed a significantly increased risk of EH in patients with CMV infection. Overall, 79.3 % of the hypertension patients were CMV-positive, which was significantly higher than the percentage for controls (OR = 1.39, 95 % CI = 0.95-2.05, P = 0.017). There was significant heterogeneity among the studies included (I(2) = 70.5 %). The funnel plot and Egger's test also indicated no publication bias.
  
  
  CONCLUSIONS
  The results showed a significant association between CMV and EH, which indicates that CMV infection is a possible cause of EH.
authors.affiliation: Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hui
authors.affiliation: Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China.|Department of Emergency and Critical Care Medicine, The First Affiliated Hospital of Medical College of Shihezi University, Shihezi, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Qu
authors.affiliation: Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China.
authors.forename: Na
authors.initials: N
authors.lastname: Tang
authors.affiliation: Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China.
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liu
authors.affiliation: Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhong
authors.affiliation: Centre of Medical Functional Experiments, Medical College of Shihezi University, Shihezi, China.
authors.forename: La-Mei
authors.initials: LM
authors.lastname: Wang
authors.affiliation: Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Feng
authors.affiliation: Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China. fangf2002shz@126.com.
authors.forename: Fang
authors.initials: F
authors.lastname: He
mesh_terms: D015897:Comorbidity; D003586:Cytomegalovirus Infections / Q000453:epidemiology*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D015994:Incidence; D008297:Male; D016016:Proportional Hazards Models; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D017678:Sex Distribution
keywords: Cytomegalovirus; Essential hypertension; Meta-analysis