title: Advances in Chemistry and Bioactivity of the Genus Chisocheton Blume.
abstract: Chisocheton is one of the genera of the family Meliaceae and consists of ca. 53 species; the distribution of most of those are confined to the Indo-Malay region. Species of broader geographic distribution have undergone extensive phytochemical investigations. Previous phytochemical investigations of this genus resulted in the isolation of mainly limonoids, apotirucallane, tirucallane, and dammarane triterpenes. Reported bioactivities of the isolated compounds include cytotoxic, anti-inflammatory, antifungal, antimalarial, antimycobacterial, antifeedant, and lipid droplet inhibitory activities. Aside from chemistry and biological activities, this review also deals briefly with botany, distribution, and uses of various species of this genus.
authors.affiliation: Centre for Natural Products and Drug Discovery, University of Malaya, Kuala Lumpur, 50603, Malaysia.|Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh.
authors.forename: Jamil A
authors.initials: JA
authors.lastname: Shilpi
authors.affiliation: Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh.
authors.forename: Sanjib
authors.initials: S
authors.lastname: Saha
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, 50603, Malaysia.
authors.forename: Soon-Lim
authors.initials: SL
authors.lastname: Chong
authors.affiliation: Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, L3 3AF, UK.
authors.forename: Lutfun
authors.initials: L
authors.lastname: Nahar
authors.affiliation: Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, L3 3AF, UK.
authors.forename: Satyajit D
authors.initials: SD
authors.lastname: Sarker
authors.affiliation: Centre for Natural Products and Drug Discovery, University of Malaya, Kuala Lumpur, 50603, Malaysia. khalijah@um.edu.my.|Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, 50603, Malaysia. khalijah@um.edu.my.
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008055:Lipids / Q000037:antagonists & inhibitors; D029582:Meliaceae / Q000737:chemistry*; D064209:Phytochemicals / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D000962:Antimalarials; D007306:Insecticides; D008055:Lipids; D064209:Phytochemicals
keywords: Apotirucallane triterpenes; Chisocheton; Dammarane triterpenes; Limonoids; Tirucallane triterpenes