title: Comparison between IV immune globulin (IVIG) and anti-D globulin for treatment of immune thrombocytopenia: a randomized open-label study.
abstract: To compare the effect of IV immune globulin (IVIG) and anti-D globulin (anti-D) for treatment of immune thrombocytopenia (ITP) in children. A randomized, open-label, single-center clinical trial was carried out in Amir-Kabir Hospital (Arak, Iran). The study was performed on 60 children with acute and chronic ITP, aged from 1 to 15 years. Patients were randomly assigned (1:1) to 50 μg/kg anti-D or 1 g/kg IVIG. Platelet counting was performed at baseline and at 3, 7, and 14 days after treatment termination. Safety assessment was performed in all patients. Anti-D caused a quicker response on the 3rd day of treatment (P < 0.001). Both drugs caused a significant rise in number of platelets on the 7th and the 14th day of treatment. Compared to IVIG, except a significant drop in hemoglobin concentration (P < 0.001), anti-D had lower rate of side effects including fever (P < 0.05), allergy (P < 0.01), and headache (P < 0.001). Our results showed that anti-D was associated with rapid rise of platelets compared to IVIG. In addition, anti-D treatment had acceptable safety profile.
authors.affiliation: Department of Pediatrics, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Aziz
authors.initials: A
authors.lastname: Eghbali
authors.affiliation: Department of Pediatrics, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Azadmanesh
authors.affiliation: Department of Pharmacology, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Bahador
authors.initials: B
authors.lastname: Bagheri
authors.affiliation: Department of Pediatrics, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Hasan
authors.initials: H
authors.lastname: Taherahmadi
authors.affiliation: Department of Social Medicine, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Bahman
authors.initials: B
authors.lastname: Sadeghi Sedeh
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage*; D007223:Infant; D008297:Male; D010976:Platelet Count / Q000379:methods; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy*; D018029:Rho(D) Immune Globulin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D018029:Rho(D) Immune Globulin
keywords: Children; ITP; IVIG; anti-D