title: The Pluripotency of Neural Crest Cells and Their Role in Brain Development.
abstract: The neural crest (NC) is, in the Chordate phylum, an innovation of vertebrates, which exhibits several original characteristics: its component cells are pluripotent and give rise to both ectodermal and mesodermal cell types. Moreover, during the early stages of neurogenesis, the NC cells exert a paracrine stimulating effect on the development of the preotic brain.
authors.affiliation: Collège de France, 3 rue d'Ulm, Paris, France; INSERM U968, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS, UMR 7210, Paris, France. Electronic address: nicole.le-douarin@college-de-france.fr.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Le Douarin
authors.affiliation: INSERM U968, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS, UMR 7210, Paris, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Dupin
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development*; D002454:Cell Differentiation; D009432:Neural Crest / Q000254:growth & development*; D055495:Neurogenesis / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000166:cytology*; D014714:Vertebrates / Q000254:growth & development*
keywords: Brain; Ectomesenchyme; Evolution; FGF8; Lineage; Neural crest; Pluripotency