title: [Catheter-based mitral valve repair by MitraClip implantation : Development, studies, and use in clinical practice].
abstract: The percutaneous edge-to-edge mitral valve repair with MitraClip® is evolving as a potential alternative to conventional surgery in high-risk patients with significant mitral regurgitation (MR). The randomized controlled EVEREST II-trial which compared percutaneous repair versus surgery in operable patients with symptomatic severe MR demonstrated superior safety of MitraClip® implantation but better MR reduction after surgery at 12 months. However, large registries on MitraClip® therapy showed that real-world MitraClip® patients differ significantly from the EVEREST II-cohort: they are older, in more advanced stages of heart failure, present predominantly with secondary MR, and exhibit a higher burden of comorbidities. For these patients, registry data confirm a low incidence of peri-interventional complications and a significant improvement of heart failure symptoms and quality of life measures after MitraClip® implantation. The ongoing RESHAPE trial with randomization of MitraClip® implantation against optimal medical therapy investigates a possible survival benefit after MitraClip® in patients with secondary MR.
authors.affiliation: Klinik für Kardiologie, Herzzentrum, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland. dr.m.puls@med.uni-goettingen.de.
authors.forename: M
authors.initials: M
authors.lastname: Puls
authors.affiliation: Klinik für Kardiologie, Herzzentrum, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.|HELIOS Albert-Schweitzer-Klinik, Northeim, Deutschland.
authors.forename: W
authors.initials: W
authors.lastname: Schillinger
mesh_terms: D006328:Cardiac Catheterization / Q000295:instrumentation / Q000379:methods*; D019317:Evidence-Based Medicine; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000295:instrumentation* / Q000379:methods; D013525:Surgical Instruments; D016896:Treatment Outcome
keywords: Heart failure; Minimally invasive procedures; Mitral regurgitation; Mortality; Risk, peri-interventional